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71. Ansari MH: Salivary gland tumors in an Iranian population: a retrospective study of 130 cases. J Oral Maxillofac Surg; 2007 Nov;65(11):2187-94
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  • [Title] Salivary gland tumors in an Iranian population: a retrospective study of 130 cases.
  • PURPOSE: Tumors of the salivary glands are uncommon, comprising 3% to 10% of head and neck neoplasia.
  • PATIENTS AND METHODS: The medical records and case notes of all patients with histologically confirmed salivary gland tumors were reviewed retrospectively from February 1984 to March 2003.
  • Tumors were localized in the parotid gland (63%; n = 82), the submandibular gland (23%; n = 30), and in the minor salivary glands (14%; n = 18).
  • Among malignant tumors, mucoepidermoid carcinoma was the most frequent (11.5%; n = 15), followed by adenocarcinoma (10%; n = 13).
  • CONCLUSION: Between benign and malignant salivary gland tumors, frequency of pleomorphic adenoma and mucoepidermoid carcinoma was in keeping with studies reported previously.
  • In other salivary gland tumors, however, diversity was obvious and showed significant difference, requiring further studies.
  • [MeSH-major] Salivary Gland Neoplasms / epidemiology
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenoma, Pleomorphic / epidemiology. Adolescent. Adult. Aged. Carcinoma, Mucoepidermoid / epidemiology. Disease-Free Survival. Female. Follow-Up Studies. Humans. Iran / epidemiology. Male. Middle Aged. Neoadjuvant Therapy. Parotid Neoplasms / epidemiology. Retrospective Studies. Salivary Glands, Minor / pathology. Submandibular Gland Neoplasms / epidemiology. Survival Rate

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  • (PMID = 17954313.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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72. Curran AE, Allen CM, Beck FM, Damm DD, Murrah VA: Distinctive pattern of glial fibrillary acidic protein immunoreactivity useful in distinguishing fragmented pleomorphic adenoma, canalicular adenoma and polymorphous low grade adenocarcinoma of minor salivary glands. Head Neck Pathol; 2007 Sep;1(1):27-32
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  • [Title] Distinctive pattern of glial fibrillary acidic protein immunoreactivity useful in distinguishing fragmented pleomorphic adenoma, canalicular adenoma and polymorphous low grade adenocarcinoma of minor salivary glands.
  • OBJECTIVES: Immunohistochemistry (IHC) can be helpful in the diagnosis of minor salivary gland neoplasms including those that have been incisionally biopsied or fragmented during surgery that do not contain key diagnostic features on hematoxylin and eosin sections.
  • IHC has been used as an adjunct to distinguish among many salivary gland neoplasms using both qualitative and quantitative methods.
  • The objective of this study was to determine whether a distinctive immunoreactivity staining pattern to GFAP can be consistently observed among three selected minor salivary gland neoplasms and thus serve as a diagnostic adjunctive procedure.
  • STUDY DESIGN: Glial fibrillary acidic protein (GFAP) reactivity was examined among 78 minor salivary gland neoplasms: 27 canalicular adenomas (CAA), 21 pleomorphic adenomas (PA) and 30 polymorphous low grade adenocarcinomas (PLGA).
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma, Pleomorphic / diagnosis. Glial Fibrillary Acidic Protein / metabolism. Salivary Gland Neoplasms / diagnosis. Salivary Glands, Minor / pathology

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  • (PMID = 20614277.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein
  • [Other-IDs] NLM/ PMC2807497
  • [Keywords] NOTNLM ; Canalicular adenoma / Glial fibrillary acidic protein / Immunohistochemistry / Pleomorphic adenoma / Polymorphous low-grade adenocarcinoma / Salivary gland neoplasms
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73. Moore BA, Burkey BB, Netterville JL, Butcher RB 2nd, Amedee RG: Surgical management of minor salivary gland neoplasms of the palate. Ochsner J; 2008;8(4):172-80
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  • [Title] Surgical management of minor salivary gland neoplasms of the palate.
  • OBJECTIVE: Minor salivary gland tumors are uncommon, accounting for up to 15% of salivary gland neoplasms.
  • We describe our experience with both benign and malignant tumors of the palatal minor salivary glands, focusing on the extent of resection and options for defect reconstruction.
  • RESULTS: From 1994 to 2002, 37 patients with primary neoplasms originating in the palatal minor salivary glands were treated at a single institution.
  • The most common malignant tumor encountered was low grade polymorphous adenocarcinoma, followed by mucoepidermoid carcinoma, and adenoid cystic carcinoma.
  • CONCLUSIONS: Neoplasms of the minor salivary glands in the palate may be excised, with limits dictated by tumor histopathology and perineural invasion.

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  • (PMID = 21603498.001).
  • [ISSN] 1524-5012
  • [Journal-full-title] The Ochsner journal
  • [ISO-abbreviation] Ochsner J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3096363
  • [Keywords] NOTNLM ; Palate / salivary gland neoplasms
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7
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4. Darling MR, Tsai S, Jackson-Boeters L, Daley TD, Diamandis EP: Human kallikrein 8 expression in salivary gland tumors. Head Neck Pathol; 2008 Sep;2(3):169-74
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  • [Title] Human kallikrein 8 expression in salivary gland tumors.
  • The human kallikrein 8 protein (KLK8) is expressed in many normal tissues including esophagus, skin, testis, tonsil, kidney, breast, and salivary gland, and is found in biological fluids including breast milk, amniotic fluid, seminal fluid and serum.
  • The aim of this study was to determine whether KLK8 is expressed in salivary gland tissues and salivary gland tumors (both benign and malignant), in order to compare normal with tumor tissues.
  • Pleomorphic adenomas, adenoid cystic carcinomas, polymorphous low grade adenocarcinomas, acinic cell carcinomas, mucoepidermoid carcinomas, and adenocarcinomas NOS of both minor and major salivary glands were examined.
  • The results of this study indicate that most salivary gland tumors show high levels of expression of KLK8.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma, Pleomorphic / metabolism. Kallikreins / metabolism. Salivary Gland Neoplasms / metabolism. Salivary Glands, Minor / metabolism

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  • (PMID = 20614312.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.21.- / KLK8 protein, human; EC 3.4.21.- / Kallikreins
  • [Other-IDs] NLM/ PMC2807567
  • [Keywords] NOTNLM ; Human kallikrein 8 / Immunohistochemistry / Kallikreins / Prognostic markers / Salivary gland tumors
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75. Hu YH, Li J: [Clear cell carcinoma of salivary gland: a clinicopathologic study of 10 cases]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2005 Jan;40(1):54-7
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  • [Title] [Clear cell carcinoma of salivary gland: a clinicopathologic study of 10 cases].
  • OBJECTIVE: To analyze the clinicopathologic features of clear cell carcinoma of salivary gland.
  • METHODS: All cases of salivary gland tumors enrolled from January 1985 to May 2004 were reviewed, and ten cases of CCC were identified and analyzed by clinicopathology and immunohistochemistry.
  • CONCLUSIONS: CCC is a distinctive low grade malignant salivary gland neoplasm, arising mainly in the minor salivary glands, and it may originate from intercalated-duct reserve cells.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 15774154.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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76. Suzuki H, Yamauchi G, Hashimoto K: Clear cell carcinoma of the mandibular gingiva 'minor salivary gland': a case report with immunohistochemical study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Mar;103(3):e36-40
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  • [Title] Clear cell carcinoma of the mandibular gingiva 'minor salivary gland': a case report with immunohistochemical study.
  • Clear cell carcinoma is a rare neoplasm that arises in salivary glands.
  • They are more frequent in the intraoral minor salivary glands than the major salivary glands.
  • This report examined the immunohistochemical characteristics of clear cell carcinoma, minor salivary gland, and reviewed the existing literature.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Gingival Neoplasms / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • (PMID = 17321437.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 68238-35-7 / Keratins
  • [Number-of-references] 14
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77. Closmann JJ, Torske KR: When a mucocele is not a mucocele: adenocarcinoma NOS--a case report and review of the literature. Gen Dent; 2007 Jul-Aug;55(4):325-7
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  • [Title] When a mucocele is not a mucocele: adenocarcinoma NOS--a case report and review of the literature.
  • Adenocarcinoma not otherwise specified (NOS) is a rare lesion of the salivary glands that can resemble a mucocele.
  • [MeSH-major] Adenocarcinoma / pathology. Mucocele / diagnosis. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • (PMID = 17682642.001).
  • [ISSN] 0363-6771
  • [Journal-full-title] General dentistry
  • [ISO-abbreviation] Gen Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 12
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78. Cho KD, Jung JH, Cho DG, Jo MS, Yoo J, Song SH, Shim BY, Kim CH, Kim HK: Primary polymorphous low-grade adenocarcinoma of lung treated by sleeve bronchial resection: a case report. J Korean Med Sci; 2007 Apr;22(2):373-6
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  • [Title] Primary polymorphous low-grade adenocarcinoma of lung treated by sleeve bronchial resection: a case report.
  • We report a surgical case of primary polymorphous low-grade adenocarcinoma (PLGA) of the minor salivary gland-type of the lung.
  • PLGAs are thought to be indolent tumors that are preferentially localized to the palate, and they affect the minor salivary glands almost exclusively.
  • To the best of our knowledge, only one case of PLGA of minor salivary gland-type of the lung without evidence of a previous oropharyngeal primary tumor has been reported in the English literature.
  • We report here the first case of a single primary PLGA of the minor salivary gland-type of the lung, which was successfully treated by sleeve bronchial resection of right upper lobe.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / surgery. Bronchi / surgery. Lung Neoplasms / secondary. Lung Neoplasms / surgery. Salivary Gland Neoplasms / surgery


79. Brandizzi D, Carino S, Cabrini RL: Ploidy studies of pleomorphic adenomas and minor salivary gland carcinomas of the palate. Acta Odontol Latinoam; 2008;21(1):105-9
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  • [Title] Ploidy studies of pleomorphic adenomas and minor salivary gland carcinomas of the palate.
  • The aim of the present study was to evaluate the DNA content of palate aggressive pleomorphic adenomas (PA) and adenocarcinomas of the salivary glands.
  • Twelve cases of salivary gland tumors of the palate were selected from the archives of the Oral Pathology Department, Faculty of Dentistry, University of Buenos Aires (1966-2001).
  • DNA content and the detection of aneuploidy would be prognostic aids in palate salivary gland carcinomas.
  • [MeSH-major] Adenocarcinoma / genetics. Adenoma, Pleomorphic / genetics. Neoplasm Invasiveness / genetics. Palate, Hard / pathology. Salivary Gland Neoplasms / genetics
  • [MeSH-minor] Aneuploidy. DNA, Neoplasm / genetics. Epithelial Cells / pathology. Humans. Mucous Membrane / pathology. Retrospective Studies. Salivary Glands, Minor / pathology

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  • (PMID = 18841754.001).
  • [ISSN] 0326-4815
  • [Journal-full-title] Acta odontológica latinoamericana : AOL
  • [ISO-abbreviation] Acta Odontol Latinoam
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Argentina
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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80. Saghravanian N, Mohtasham N, Jafarzadeh H: Comparison of immunohistochemical markers between adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. J Oral Sci; 2009 Dec;51(4):509-14
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  • [Title] Comparison of immunohistochemical markers between adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma.
  • Adenoid cystic carcinoma (AdCC) and polymorphous low-grade adenocarcinoma (PLGA) have several common histological and clinicopathological features that may create diagnostic difficulties.
  • In this study, 10 AdCCs, 8 PLGAs, and 5 normal minor salivary glands as a control group were selected.
  • [MeSH-major] Adenocarcinoma / chemistry. Biomarkers, Tumor. Carcinoma, Adenoid Cystic / chemistry. Salivary Gland Neoplasms / chemistry


81. Pons Vicente O, Almendros Marqués N, Berini Aytés L, Gay Escoda C: Minor salivary gland tumors: A clinicopathological study of 18 cases. Med Oral Patol Oral Cir Bucal; 2008 Sep;13(9):E582-8
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  • [Title] Minor salivary gland tumors: A clinicopathological study of 18 cases.
  • INTRODUCTION: Minor salivary gland tumors (MSGTs) are infrequent, representing 10-15% of all salivary neoplasms.
  • The histopathological diagnoses of our MSGTs comprised 10 pleomorphic adenomas (55.3%), 2 cystadenomas (11.1%), 1 myoepithelioma (5.6%), 1 sialadenoma papilliferum (5.6%), 1 basal cell adenoma (5.6%), 1 Warthin's tumor (5.6%), 1 canalicular adenoma (5.6%), and 1 low-grade polymorphic adenocarcinoma (5.6%).
  • Six percent of all benign minor salivary gland tumors are considered to relapse, versus 65% of all malignant lesions.
  • [MeSH-major] Salivary Gland Neoplasms / pathology. Salivary Glands, Minor

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  • (PMID = 18758404.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 30
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82. Gil Z, Carlson DL, Gupta A, Lee N, Hoppe B, Shah JP, Kraus DH: Patterns and incidence of neural invasion in patients with cancers of the paranasal sinuses. Arch Otolaryngol Head Neck Surg; 2009 Feb;135(2):173-9
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  • Patients with NI were more likely to undergo adjuvant radiotherapy (P = .003), which significantly improved survival in patients with minor salivary gland carcinomas (P = .04).
  • [MeSH-minor] Adenocarcinoma / pathology. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma / pathology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Squamous Cell / pathology. Child. Female. Humans. Male. Melanoma / pathology. Middle Aged. Neoplasm Invasiveness. Retrospective Studies. Skull Base Neoplasms / pathology

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  • (PMID = 19221246.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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83. Wang H, Yao J, Solomon M, Axiotis CA: Sebaceous carcinoma of the oral cavity: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Aug;110(2):e37-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Fordyce granules and a minor salivary gland with a duct were identified in vicinity to the tumor.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Mouth Neoplasms / pathology

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  • [Copyright] Copyright 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20659693.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Androgen
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84. Prasad ML, Barbacioru CC, Rawal YB, Husein O, Wen P: Hierarchical cluster analysis of myoepithelial/basal cell markers in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. Mod Pathol; 2008 Feb;21(2):105-14
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  • [Title] Hierarchical cluster analysis of myoepithelial/basal cell markers in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma.
  • Distinguishing adenoid cystic carcinoma from polymorphous low-grade adenocarcinoma of the salivary glands is important for their management.
  • We studied the expression of several myoepithelial and basal/stem cell markers (smooth muscle actin, calponin, smooth muscle myosin heavy chain, metallothionein, maspin, and p63) by immunohistochemistry in 23 adenoid cystic carcinoma and 24 polymorphous low-grade adenocarcinoma, to identify the most useful marker or combination of markers that may help their diagnoses.
  • We noted diffuse expression of smooth muscle actin in 20 adenoid cystic carcinoma vs one polymorphous low-grade adenocarcinoma (P<0.0001), calponin in 15 adenoid cystic carcinoma vs one polymorphous low-grade adenocarcinoma (P<0.0001), smooth muscle myosin heavy chain in 15 adenoid cystic carcinoma vs one polymorphous low-grade adenocarcinoma (P=0.001), metallothionein in 22 adenoid cystic carcinoma vs eight polymorphous low-grade adenocarcinoma (P<0.001), maspin in 22 adenoid cystic carcinoma vs 14 polymorphous low-grade adenocarcinoma, and p63 in 21 adenoid cystic carcinoma vs 14 polymorphous low-grade adenocarcinoma.
  • In differentiating adenoid cystic carcinoma from polymorphous low-grade adenocarcinoma, smooth muscle actin as a single ancillary test in support of the histological findings, appears to be as efficient as multiple immunohistochemical tests.
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Adenoid Cystic / metabolism. Epithelial Cells / metabolism. Myocytes, Smooth Muscle / metabolism. Neoplasm Proteins / metabolism. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cluster Analysis. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Lymph Nodes / pathology. Male. Middle Aged. Neoplasm Recurrence, Local. Salivary Glands, Minor / metabolism. Salivary Glands, Minor / pathology. Treatment Outcome


85. Tarakji B, Nassani MZ, Sloan P: Immunohistochemical expression of estrogens and progesterone receptors in carcinoma ex pleomorphic adenoma-undifferentiated and adenocarcinoma types. Med Oral Patol Oral Cir Bucal; 2010 May;15(3):e432-6
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  • [Title] Immunohistochemical expression of estrogens and progesterone receptors in carcinoma ex pleomorphic adenoma-undifferentiated and adenocarcinoma types.
  • Cancer of the salivary gland is one of the common cancers in the head and the neck regions.
  • This type of cancer develops in the minor and the major salivary glands, and it sometimes metastasizes to other organs, particularly the lung.
  • Morphologic mimicry and similarity in the expression of steroid hormone receptors between salivary gland tumours and breast tumours are well-known phenomena and are occasionally debated in the field of surgical pathology.
  • Previous studies of the expression of estrogens and progesterone receptors in salivary gland tumours have reported conflicting results.
  • STUDY DESIGN: 27 cases of carcinoma arising in pleomorphic adenoma (undifferentiated and adenocarcinoma types) were examined.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma, Pleomorphic / metabolism. Neoplasms, Multiple Primary / metabolism. Receptors, Estrogen / biosynthesis. Receptors, Progesterone / biosynthesis. Salivary Gland Neoplasms / metabolism

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  • (PMID = 20038908.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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86. Pogodzinski MS, Sabri AN, Lewis JE, Olsen KD: Retrospective study and review of polymorphous low-grade adenocarcinoma. Laryngoscope; 2006 Dec;116(12):2145-9
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  • [Title] Retrospective study and review of polymorphous low-grade adenocarcinoma.
  • OBJECTIVES/HYPOTHESIS: We review a single institution's experience with polymorphous low-grade adenocarcinoma.
  • To our knowledge, this is the largest patient series of polymorphous low-grade adenocarcinoma with clinical follow-up in the otolaryngology literature.
  • STUDY DESIGN: We retrospectively identified 19 patients with polymorphous low-grade adenocarcinoma who had adequate clinical follow-up and pathologic specimens available for examination.
  • The most common initial diagnoses were polymorphous low-grade adenocarcinoma, adenoid cystic carcinoma, and pleomorphic adenoma.
  • CONCLUSIONS: Polymorphous low-grade adenocarcinoma is an increasingly recognized malignancy that originates predominantly in the minor salivary gland.
  • [MeSH-major] Adenocarcinoma / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Retrospective Studies. Salivary Glands, Minor


87. Paleri V, Robinson M, Bradley P: Polymorphous low-grade adenocarcinoma of the head and neck. Curr Opin Otolaryngol Head Neck Surg; 2008 Apr;16(2):163-9
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  • [Title] Polymorphous low-grade adenocarcinoma of the head and neck.
  • PURPOSE OF REVIEW: Polymorphous low-grade adenocarcinoma is an entity described in 1984.
  • An increasing number of reports in the pathology literature since then have identified this as the second or the third most common minor salivary gland malignancy.
  • The natural history of polymorphous low-grade adenocarcinoma is distinct from other malignant salivary tumours.
  • RECENT FINDINGS: Polymorphous low-grade adenocarcinoma is a slow-growing tumour that is locally invasive.
  • The role of radiation therapy is not clear in the management of polymorphous low-grade adenocarcinoma.
  • SUMMARY: Polymorphous low-grade adenocarcinoma is primarily a pathologic diagnosis.
  • [MeSH-major] Adenocarcinoma / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 18327037.001).
  • [ISSN] 1531-6998
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 60
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88. Marotta Reis de Vasconcellos L, Avila Sarmento Silveira V, Eduardo Blumer Rosa L, Sueli Rodrigues Cavalvante A, Rodarte Carvalho Y: Immunohistochemistry as a fundamental tool for the differential diagnosis of polymorphous low-grade adenocarcinoma. Quintessence Int; 2006 Jul-Aug;37(7):565-73
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  • [Title] Immunohistochemistry as a fundamental tool for the differential diagnosis of polymorphous low-grade adenocarcinoma.
  • Polymorphous low-grade adenocarcinoma (PLGA) is a subtype of salivary gland carcinoma with a marked predilection for the minor salivary glands.
  • The diagnosis of this lesion can be a challenge in incisional biopsies because of its similarity to other salivary neoplasms and the difficulty of analyzing its infiltrative nature and neurotropism.
  • PLGA is a tumor of the salivary gland that must be distinguished from other neoplasms for therapeutic and prognostic considerations, and the panel of antibodies employed in this study was effective for its diagnosis.
  • [MeSH-major] Adenocarcinoma / diagnosis. Salivary Gland Neoplasms / diagnosis. Salivary Glands, Minor / pathology


89. Darling MR, Tsai S, Jackson-Boeters L, Daley TD, Diamandis EP: Human kallikrein 3 (prostate specific antigen) and human kallikrein 5 expression in salivary gland tumors. Int J Biol Markers; 2006 Oct-Dec;21(4):201-5
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  • [Title] Human kallikrein 3 (prostate specific antigen) and human kallikrein 5 expression in salivary gland tumors.
  • The human kallikrein 5 protein (hK5) is expressed in many normal tissues, most notably in skin, breast, salivary gland and esophagus.
  • Human kallikrein 3 (hK3; prostate-specific antigen) is the most useful marker for adenocarcinoma of the prostate gland.
  • The aim of this study was to determine whether hK3 and hK5 are expressed in salivary gland tissues and salivary gland tumors (both benign and malignant), in order to compare normal with tumor tissues.
  • Pleomorphic adenomas, adenoid cystic carcinomas, polymorphous low-grade adenocarcinomas, acinic cell carcinomas, mucoepidermoid carcinomas and adenocarcinomas not otherwise specified of both minor and major salivary glands were examined.
  • The results of this study indicate that most salivary gland tumors do not show high levels of expression of hK5.
  • Staining was most prominent in keratinizing epithelia in pleomorphic adenomas. hK3 is not expressed in salivary gland tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. Kallikreins / analysis. Prostate-Specific Antigen / analysis. Salivary Gland Neoplasms / chemistry

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  • (PMID = 17177156.001).
  • [ISSN] 0393-6155
  • [Journal-full-title] The International journal of biological markers
  • [ISO-abbreviation] Int. J. Biol. Markers
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.21.- / Kallikreins; EC 3.4.21.- / kallikrein 5, human; EC 3.4.21.77 / Prostate-Specific Antigen
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90. Yih WY, Kratochvil FJ, Stewart JC: Intraoral minor salivary gland neoplasms: review of 213 cases. J Oral Maxillofac Surg; 2005 Jun;63(6):805-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraoral minor salivary gland neoplasms: review of 213 cases.
  • PURPOSE: Minor salivary gland tumors (MSGTs) constitute a heterogeneous group of neoplasms with great histomorphologic variation.
  • This study reviews a large series of benign and malignant salivary gland tumors of the oral region and determines the incidence and the correlation of the histopathologic features with the clinical characteristics.
  • Of the 94 malignant MSGTs, mucoepidermoid carcinoma (MEC) (45 of 94), adenoid cystic carcinoma (22 of 94), and polymorphous low-grade adenocarcinoma (18 of 94) were the most common.
  • The palate is the most common site for minor gland neoplasms.
  • Benign labial salivary gland neoplasms are more common in the upper lip, and malignant labial tumors are more common in the lower lip.
  • [MeSH-major] Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adenoma / pathology. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / pathology. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 15944978.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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91. Angiero F, Stefani M: Hyalinizing clear cell carcinoma arising on the anterior palatoglossal arch. Anticancer Res; 2007 Nov-Dec;27(6C):4271-7
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  • Hyalinizing clear cell carcinoma (HCCC) is very rare in the oral cavity, arising more frequently in the minor salivary glands.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Mouth Neoplasms / pathology. Palatal Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Hyalin. Immunohistochemistry. Middle Aged. Palate, Hard / pathology. Palate, Hard / surgery. Salivary Gland Neoplasms / pathology

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  • (PMID = 18214031.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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92. Mücke T, Kesting MR, Hohlweg-Majert B, Hölzle F, Wolff KD: The role of bronchoscopy and gastroscopy in intraoral minor salivary gland carcinomas at initial staging. Br J Oral Maxillofac Surg; 2009 Dec;47(8):608-11
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  • [Title] The role of bronchoscopy and gastroscopy in intraoral minor salivary gland carcinomas at initial staging.
  • Intraoral minor salivary gland carcinomas are rare tumours the incidence, distribution, and prognostic factors of which differ.
  • The aim of this study was to assess the value of bronchoscopy and gastroscopy in the routine staging of minor salivary gland cancers.
  • We retrospectively reviewed the casenotes of 95 patients who had presented with newly diagnosed intraoral minor salivary gland carcinomas.
  • For therapeutic, diagnostic, and prognostic reasons bronchoscopy and gastroscopy should be included routinely into staging of intraoral minor salivary gland carcinomas.
  • [MeSH-major] Bronchoscopy. Carcinoma / pathology. Gastroscopy. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Biopsy. Bronchitis / diagnosis. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / pathology. Esophageal Neoplasms / diagnosis. Female. Gastroenteritis / diagnosis. Humans. Lung Neoplasms / diagnosis. Lung Neoplasms / secondary. Male. Mass Screening. Middle Aged. Mouth Mucosa / pathology. Neoplasm Staging. Neoplasms, Multiple Primary / diagnosis. Palate / pathology. Retrospective Studies

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  • (PMID = 19162382.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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93. Andreadis D, Nomikos A, Epivatianos A, Poulopoulos A, Barbatis C: Basaloid squamous cell carcinoma versus basal cell adenocarcinoma of the oral cavity. Pathology; 2005 Dec;37(6):560-3
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  • [Title] Basaloid squamous cell carcinoma versus basal cell adenocarcinoma of the oral cavity.
  • [MeSH-major] Carcinoma, Basosquamous / pathology. Carcinoma, Squamous Cell / pathology. Oropharyngeal Neoplasms / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology


94. Toida M, Shimokawa K, Makita H, Kato K, Kobayashi A, Kusunoki Y, Hatakeyama D, Fujitsuka H, Yamashita T, Shibata T: Intraoral minor salivary gland tumors: a clinicopathological study of 82 cases. Int J Oral Maxillofac Surg; 2005 Jul;34(5):528-32
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  • [Title] Intraoral minor salivary gland tumors: a clinicopathological study of 82 cases.
  • We present a retrospective study of 82 patients with intraoral minor salivary gland tumors which were diagnosed from 1979 to 2003 in Gifu University Hospital.
  • Histologically, the tumors were classified as pleomorphic adenoma (n = 54), papillary cystadenoma (n = 1), adenoid cystic carcinoma (n = 10), mucoepidermoid carcinoma (n = 8), acinic cell carcinoma (n = 3), adenocarcinoma (n = 2), basal cell adenocarcinoma (n = 1), papillary cystadenocarcinoma (n = 1), and carcinoma in pleomorphic adenoma (n = 2).
  • From the results of the present study and review of the literature, it is suggested that the minor salivary gland tumors in Japan may be characterized by a higher incidence of benign tumors, especially of pleomorphic adenoma; a more marked tendency for female predominance; a higher incidence of palatal involvement; and a rarer occurrence of polymorphous low grade adenocarcinoma, in comparison with those reported in the literature from outside of Japan.
  • [MeSH-major] Salivary Gland Neoplasms / epidemiology. Salivary Glands, Minor / pathology
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenoma, Pleomorphic / epidemiology. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Mucoepidermoid / epidemiology. Cheek / pathology. Child. Female. Humans. Japan / epidemiology. Lip / pathology. Male. Middle Aged. Palate / pathology. Retrospective Studies. Sex Factors

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  • (PMID = 16053873.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
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95. Mocan S, Stolnicu S, Rădulescu D, Petrovan C: [Acinic cell adenocarcinoma of the lip]. Rev Med Chir Soc Med Nat Iasi; 2005 Jan-Mar;109(1):164-9
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  • [Title] [Acinic cell adenocarcinoma of the lip].
  • We present the case of a 68 years old women, with a salivary cyst localised in the upper lip.
  • Acinic cell adenocarcinoma is a malignant epithelial neoplasm in which the neoplastic cells demonstrate not only serous acinar differentiation.
  • [MeSH-major] Carcinoma, Acinar Cell / pathology. Lip Neoplasms / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Female. Humans. Salivary Glands, Minor / pathology. Treatment Outcome

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  • (PMID = 16607848.001).
  • [ISSN] 0048-7848
  • [Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
  • [ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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96. Dhanuthai K, Boonadulyarat M, Jaengjongdee T, Jiruedee K: A clinico-pathologic study of 311 intra-oral salivary gland tumors in Thais. J Oral Pathol Med; 2009 Jul;38(6):495-500
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A clinico-pathologic study of 311 intra-oral salivary gland tumors in Thais.
  • BACKGROUND: There have been several epidemiologic studies on intra-oral salivary gland tumors in several countries, but little is known of these tumors in Thailand.
  • OBJECTIVES: To determine the relative frequency and distribution of various types of intra-oral salivary gland tumors in the Thai population.
  • METHODS: The files of the Department of Oral Pathology, Faculty of Dentistry, Chulalongkorn University, from 1969 to 2007 were searched for intra-oral salivary gland tumors.
  • RESULTS: Of the 16,358 accessioned cases, 311 cases (1.90%) were diagnosed as intra-oral salivary gland tumors.
  • Pleomorphic adenoma was the most common intra-oral salivary gland tumor.
  • CONCLUSIONS: Pleomorphic adenoma is the most common intra-oral salivary gland tumor and the most common benign intra-oral salivary gland tumor, while mucoepidermoid carcinoma is the most common malignant intra-oral salivary gland tumor.
  • Intra-oral salivary gland tumors in Thailand elicit similar trend as in previous studies, with only minor differences such as the ranking of some tumors, the higher incidence of intra-bony location, and the lower incidence of polymorphous low-grade adenocarcinoma.
  • [MeSH-major] Salivary Gland Neoplasms / epidemiology
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenoma / epidemiology. Adenoma, Pleomorphic / epidemiology. Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Mucoepidermoid / epidemiology. Child. Female. Humans. Incidence. Male. Middle Aged. Palatal Neoplasms / epidemiology. Retrospective Studies. Sex Factors. Thailand / epidemiology. Young Adult

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  • (PMID = 19594840.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
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