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Items 1 to 54 of about 54
1. Shibakuki R, Seto T, Uematsu K, Shimizu K, Seki N, Nakano M, Ishii H, Ohta M, Eguchi K: Pulmonary adenocarcinoma associated with SAPHO syndrome difficult to differentiate from multiple bone metastasis. Intern Med; 2006;45(8):543-6
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  • [Title] Pulmonary adenocarcinoma associated with SAPHO syndrome difficult to differentiate from multiple bone metastasis.
  • The patient was a 57-year-old man with a chief complaint of anterior chest pain who was diagnosed with clinical stage IV (c-T2N2M1) non-small-cell lung cancer (adenocarcinoma).
  • Bone scintigraphy showed tracer accumulation in the costal cartilage, sternoclavicular joint, and cervical vertebrae 6-7.
  • Although the bone lesions of SAPHO syndrome were difficult to differentiate from bone metastasis of pulmonary adenocarcinoma, metastatic bone tumors were ruled out by magnetic resonance imaging, computed tomography, and fluorodeoxyglucose positron emission tomography.
  • There have been no previously reported cases of lung cancer with comorbid SAPHO syndrome.
  • We report such a case and discuss the relevant literature, particularly that concerned with the evaluation of bone lesions.
  • [MeSH-major] Acquired Hyperostosis Syndrome / complications. Adenocarcinoma / complications. Adenocarcinoma / secondary. Bone Neoplasms / diagnosis. Bone Neoplasms / secondary. Lung Neoplasms / complications
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 16702748.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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2. Nguyen DX, Chiang AC, Zhang XH, Kim JY, Kris MG, Ladanyi M, Gerald WL, Massagué J: WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Cell; 2009 Jul 10;138(1):51-62
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  • [Title] WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis.
  • Metastasis from lung adenocarcinoma can occur swiftly to multiple organs within months of diagnosis.
  • The mechanisms that confer this rapid metastatic capacity to lung tumors are unknown.
  • Activation of the canonical WNT/TCF pathway is identified here as a determinant of metastasis to brain and bone during lung adenocarcinoma progression.
  • Gene expression signatures denoting WNT/TCF activation are associated with relapse to multiple organs in primary lung adenocarcinoma.
  • Metastatic subpopulations isolated from independent lymph node-derived lung adenocarcinoma cell lines harbor a hyperactive WNT/TCF pathway.
  • Reduction of TCF activity in these cells attenuates their ability to form brain and bone metastases in mice, independently of effects on tumor growth in the lungs.
  • Thus, a distinct WNT/TCF signaling program through LEF1 and HOXB9 enhances the competence of lung adenocarcinoma cells to colonize the bones and the brain.


3. Tohfe M, Baki SA, Saliba W, Ghandour F, Ashou R, Ghazal G, Bahous J, Chamseddine N: Metastatic prostate adenocarcinoma presenting with pulmonary symptoms: a case report and review of the literature. Cases J; 2008;1(1):316

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  • [Title] Metastatic prostate adenocarcinoma presenting with pulmonary symptoms: a case report and review of the literature.
  • INTRODUCTION: Prostate cancer has a high tendency to spread to bone.
  • Pulmonary metastasis and generalized lymphadenopathy commonly develop after pelvic and bone involvement have already occurred.
  • Few patients with prostate cancer present initially with symptomatic metastatic lung lesions and lymphadenopathy without any other concomitant distant dissemination.
  • A chest X-ray was done revealing multiple "cannon ball" infiltrates involving all segments of the lung parenchyma.
  • Despite the absence of any detectable osseous lesions and with the presence of multiple hilar, mediastinal, para-aortic, and pelvic lymphadenopathy, the patient had a complete work-up in search for the primary adenocarcinoma.
  • His prostate specific antigen was 146 ng/ml and a prostatic biopsy done, revealing an acinar prostatic adenocarcinoma.
  • A tru-cut biopsy of a lung lesion under computed tomography guidance showed a metastatic prostatic adenocarcinoma positive for prostate specific antigen stain.
  • CONCLUSION: This case sheds light on an unusual metastatic pattern of prostatic adenocarcinoma.
  • It also emphasizes the importance of including prostate cancer in the differential diagnosis of men with adenocarcinoma of unknown origin.

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  • [Cites] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387.001]
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  • (PMID = 19014682.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2590613
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4. Parlea L, Fahim L, Munoz D, Hanna A, Anderson J, Cusimano M, Kovacs K, Gardiner G: Follicular carcinoma of the thyroid with aggressive metastatic behavior in a pregnant woman: report of a case and review of the literature. Hormones (Athens); 2006 Oct-Dec;5(4):295-302
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  • [Title] Follicular carcinoma of the thyroid with aggressive metastatic behavior in a pregnant woman: report of a case and review of the literature.
  • We report the clinical and pathological features of a 33-year old pregnant patient with follicular carcinoma of the thyroid who presented with widespread bone and lung metastases at the time of diagnosis. the resected tumor had a focal insular component that showed extensive vascular invasion spreading beyond the thyroid capsule, and was associated with widespread bone and lung metastases.
  • We suggest that architectural differentiation of the tumor and cell proliferation rate are not reliable markers of metastatic behavior in this particular thyroid neoplasm.
  • Microvascular density and down-regulation of E-cadherin expression in the tumor should be included among histologic hallmarks of metastatic potential. the role of pregnancy in the aggressive behavior of this tumor is discussed along with a literature review.
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Bone Neoplasms / secondary. Lung Neoplasms / secondary. Pregnancy Complications, Neoplastic / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 17178705.001).
  • [ISSN] 1109-3099
  • [Journal-full-title] Hormones (Athens, Greece)
  • [ISO-abbreviation] Hormones (Athens)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Cadherins
  • [Number-of-references] 47
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5. Tazi N, Le Thi Huong D, Bodaghi B, Rixe O, Lehoang P, Piette JC: [Choroidal metastasis revealing pulmonary adenocarcinoma]. Rev Med Interne; 2006 Sep;27(9):699-701
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  • [Title] [Choroidal metastasis revealing pulmonary adenocarcinoma].
  • Lung cancer is the first cause of choroidal metastasis in man.
  • He presented with visual decrease and metamorphopsia that lead to the diagnosis of a metastatic adenocarcinoma of the lung (bone, liver, choroid, nodles).

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  • (PMID = 16872723.001).
  • [ISSN] 0248-8663
  • [Journal-full-title] La Revue de medecine interne
  • [ISO-abbreviation] Rev Med Interne
  • [Language] FRE
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Phytogenic; 0 / Taxoids; 15H5577CQD / docetaxel; Q20Q21Q62J / Cisplatin
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6. Segawa N, Abe H, Nishida T, Katsuoka Y: [A case of prostatic cancer discovered from lung metastatic lesions]. Hinyokika Kiyo; 2006 Feb;52(2):147-9
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  • [Title] [A case of prostatic cancer discovered from lung metastatic lesions].
  • We report a case in a 70-year-old patient indicated to have a metastatic lesion from a chest X-ray taken during a medical examination.
  • Transrectal sextant needle biopsy of the prostate was performed, revealing moderately differentiated adenocarcinoma.
  • Computed tomography (CT) scan and bone scintigraphy showed intrapelvic lymphnode adenopathy and metastasis to the right pubic bone.
  • Under a diagnosis of stage D2 prostate cancer, we initiated endocrine therapy (luteinizing hormone-releasing hormone analogue depot every 4 weeks and bicalutamide).
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / secondary. Antineoplastic Agents, Hormonal / administration & dosage. Lung Neoplasms / secondary. Prostate-Specific Antigen / blood. Prostatic Neoplasms / drug therapy. Prostatic Neoplasms / pathology


7. Wu Y, Yao LQ, Cheng J, Tian H: [Diagnostic value of bone marrow biopsy for bone marrow metastatic tumor with unknown primary tumor site]. Nan Fang Yi Ke Da Xue Xue Bao; 2010 May;30(5):1069-71

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  • [Title] [Diagnostic value of bone marrow biopsy for bone marrow metastatic tumor with unknown primary tumor site].
  • OBJECTIVE: To explore the diagnostic value of bone marrow biopsy for bone marrow metastatic tumor with unknown primary tumor site.
  • METHODS: Thirty-eight cases of metastatic bone marrow tumors were diagnosed by light microscopy, and the bone marrow samples from these cases with unknown primary tumor sites were examined by immunohistochemistry.
  • RESULTS: In all the cases, the bone marrow was infiltrated by tumor cells between the bone trabecula.
  • Immunohistochemistry identified the primary tumor sites in these cases, including 12 stomach cancers, 10 breast cancers, 8 prostate cancers, 4 lung cancers, 1 dorsal melanoma, 1 left foot melanoma, and 2 nasopharyngeal cancers.
  • CONCLUSION: Proper immunohistochemistry can help determine the primary tumor sites in patients with metastatic bone marrow tumor with unknown primary tumor sites.
  • [MeSH-major] Adenocarcinoma / secondary. Bone Marrow Examination / methods. Bone Marrow Neoplasms / diagnosis. Bone Marrow Neoplasms / secondary. Neoplasms, Unknown Primary / diagnosis
  • [MeSH-minor] Adult. Aged. Biopsy, Needle. Female. Humans. Lung Neoplasms / diagnosis. Lung Neoplasms / pathology. Male. Middle Aged. Stomach Neoplasms / diagnosis. Stomach Neoplasms / pathology

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  • (PMID = 20501396.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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8. Yanagitani N, Kaira K, Ishizuka T, Aoki H, Utsugi M, Shimizu Y, Sunaga N, Endou K, Hisada T, Mori M: Multiple lung metastases presenting as ground-glass opacities in a pulmonary adenocarcinoma: a case report. Cases J; 2009;2:6910

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  • [Title] Multiple lung metastases presenting as ground-glass opacities in a pulmonary adenocarcinoma: a case report.
  • INTRODUCTION: Focal ground-glass opacity on computed tomography suggests several disorders including inflammatory disease, fibrosis, or a primary lung neoplastic lesion, metastatic lung tumor.
  • CASE PRESENTATION: The case of a 55-year-old female presenting with adenocarcinoma of the lung is herein reported.
  • Computed tomography of the chest revealed a primary mass lesion in the upper lobe of the right lung and multiple metastases presenting as ground-glass opacities.
  • Macroscopic metastases were observed in the bone, the hilar and mediastinal lymph nodes, and another lobe.
  • This case was advanced lung cancer.
  • CONCLUSION: A metastatic lung tumor showing ground-glass opacity is uncommon.
  • It is quite difficult to distinguish between multiple primary lung cancers and intrapulmonary metastasis when patients present with multiple lung nodules.
  • A lot of clinical information is therefore required to make an accurate diagnosis in such cases.

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  • [Cites] Ann Thorac Surg. 2005 Jan;79(1):e1-2 [15620900.001]
  • [Cites] Ann Thorac Surg. 2006 Oct;82(4):1508-10 [16996967.001]
  • (PMID = 19829882.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2740189
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9. Hill HC: Challenges of utilizing immunostains to facilitate the diagnosis and management of metastatic adenocarcinoma. J Natl Med Assoc; 2008 Dec;100(12):1469-73
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  • [Title] Challenges of utilizing immunostains to facilitate the diagnosis and management of metastatic adenocarcinoma.
  • Treatment is based upon the results of several diagnostic radiographic modalities that may locate the occult primary and determine the extent of metastatic tumor burden.
  • We describe metastatic adenocarcinoma of unknown primary presenting as a pericardial effusion and coincident supraclavicular adenopathy.
  • The patient completed the chemotherapy and had stable metastatic tumor burden with an acceptable quality of life.
  • Two years after initial diagnosis, the patient expired because of disease progression.
  • Although immunohistochemical staining initially suggested metastatic breast carcinoma, her clinical course confirmed a lung primary.
  • [MeSH-major] Adenocarcinoma / secondary. Lung Neoplasms / diagnosis. Lung Neoplasms / pathology. Neoplasms, Unknown Primary / diagnosis
  • [MeSH-minor] Adult. Bone Neoplasms / secondary. Brain Neoplasms / secondary. Bromhexine. Fatal Outcome. Female. Humans. Immunohistochemistry. Pericardial Effusion / pathology

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  • [CommentIn] J Natl Med Assoc. 2009 May;101(5):478 [19476202.001]
  • (PMID = 19110917.001).
  • [ISSN] 1943-4693
  • [Journal-full-title] Journal of the National Medical Association
  • [ISO-abbreviation] J Natl Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] Q1J152VB1P / Bromhexine
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10. Mego M, Sycova-Mila Z, Martanovic P, Liskova S, Obertova J, Mardiak J: Inflammatory skin metastasis as a first sign of progression of lung cancer--a case report. Klin Onkol; 2010;23(6):449-51
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  • [Title] Inflammatory skin metastasis as a first sign of progression of lung cancer--a case report.
  • ICM in lung cancer are extremely rare and often misdiagnosed.
  • PATIENTS AND METHODS: We report on a 55-year-old man with metastatic lung adenocarcinoma and bone metastases in the axial skeleton and left humerus diagnosed in August 2008.
  • A diagnosis of skin infection was made and he was treated by antibiotic therapy without improvement.
  • RESULTS: Skin biopsy revealed skin infiltration by poorly differentiated carcinoma compatible with a primary lung tumour.
  • CONCLUSION: Metastasis of lung carcinoma could be one of the causes of inflammatory skin lesions in cancer patients and these metastases should be considered in cancer patients with persisting cutaneous lesions with signs of inflammation and no response to antibiotic therapy.
  • [MeSH-major] Adenocarcinoma / secondary. Lung Neoplasms / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Bone Neoplasms / secondary. Humans. Male. Middle Aged. Skin / pathology

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  • (PMID = 21348413.001).
  • [ISSN] 0862-495X
  • [Journal-full-title] Klinická onkologie : casopis Ceské a Slovenské onkologické spolecnosti
  • [ISO-abbreviation] Klin Onkol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Czech Republic
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11. Keramidas E, Brotherston M: Extensive metastasis to the hand from undiagnosed adenocarcinoma of the lung. Scand J Plast Reconstr Surg Hand Surg; 2005;39(2):113-5
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  • [Title] Extensive metastasis to the hand from undiagnosed adenocarcinoma of the lung.
  • Metastatic tumours of the hand are uncommon; we present a case of undiagnosed adenocarcinoma of the lung with extensive metastases to the carpal, and to the third, fourth, and fifth metacarpal, bones.
  • Biopsy confirmed the diagnosis and the patient died three months later, no surgical treatment being offered.

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  • (PMID = 16019740.001).
  • [ISSN] 0284-4311
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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12. Sato T, Soejima K, Nakayama S, Satomi R, Sayama K, Asano K: [A case of fat embolism syndrome associated with pathological femoral fracture caused by metastatic adenocarcinoma of the lung]. Nihon Kokyuki Gakkai Zasshi; 2010 Oct;48(10):765-8
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  • [Title] [A case of fat embolism syndrome associated with pathological femoral fracture caused by metastatic adenocarcinoma of the lung].
  • A 76-year-old woman with multiple bone metastases from lung adenocarcinoma was admitted due to a pathological femoral fracture.
  • Fat embolism syndrome should be considered as a differential diagnosis if consciousness disturbance and respiratory failure occur in patients with metastatic bone carcinoma and pathological long bone fractures.
  • [MeSH-major] Adenocarcinoma / complications. Embolism, Fat / etiology. Femoral Fractures / etiology. Fractures, Spontaneous / etiology. Lung Neoplasms / complications
  • [MeSH-minor] Aged. Bone Neoplasms / secondary. Female. Humans

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  • (PMID = 21066866.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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13. McLean SR, Shousha S, Francis N, Lim A, Eccles S, Nathan M, Brock CS, Palmieri C: Metastatic ductal eccrine adenocarcinoma masquerading as an invasive ductal carcinoma of the male breast. J Cutan Pathol; 2007 Dec;34(12):934-8
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  • [Title] Metastatic ductal eccrine adenocarcinoma masquerading as an invasive ductal carcinoma of the male breast.
  • We report the case of a 38-year-old man with metastatic ductal eccrine adenocarcinoma (DEA) of the left breast responding to 5-flourouracil, epirubicin and cyclophosphamide (FEC) chemotherapy.
  • A punch biopsy of the breast lesion resulted in a diagnosis of metastatic invasive ductal carcinoma (IDC) of the breast.
  • Both the morphological and the immunohistochemical characteristics of the tumor were consistent with a revised diagnosis of DEA rather than IDC.
  • In addition, clinical response to FEC by metastatic DEA has not been previously documented, and this therapeutic regimen warrants further investigation.
  • [MeSH-major] Adenocarcinoma / pathology. Breast Neoplasms, Male / pathology. Carcinoma, Ductal, Breast / pathology. Eccrine Glands / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Bone Density Conservation Agents / therapeutic use. Bone Neoplasms / secondary. Bone Neoplasms / therapy. Cyclophosphamide / therapeutic use. Diphosphonates / therapeutic use. Epirubicin / therapeutic use. Fluorouracil / therapeutic use. Humans. Immunohistochemistry. Lung Neoplasms / secondary. Lung Neoplasms / therapy. Lymphatic Metastasis / pathology. Male. Radiotherapy. Tamoxifen / therapeutic use. Tomography, X-Ray Computed

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  • (PMID = 18001417.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Bone Density Conservation Agents; 0 / Diphosphonates; 094ZI81Y45 / Tamoxifen; 114084-78-5 / ibandronic acid; 3Z8479ZZ5X / Epirubicin; 8N3DW7272P / Cyclophosphamide; U3P01618RT / Fluorouracil
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14. Ahmed I, Robinson CM, Patton JT, Cook RE: Metastatic adenocarcinoma after intramedullary fixation of a tibial fracture: A report of two cases. J Bone Joint Surg Br; 2010 Nov;92(11):1592-5
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  • [Title] Metastatic adenocarcinoma after intramedullary fixation of a tibial fracture: A report of two cases.
  • We present two cases of metastatic lung cancer which occurred at the site of a previously united tibial fracture.
  • We are unaware of any previous reports of a metastatic tumour occurring at the site of an orthopaedic implant used to stabilise a non-pathological fracture.
  • These cases demonstrate the similar clinical presentation of infection and malignancy: a diagnosis which should always be considered in such patients.
  • [MeSH-major] Adenocarcinoma / secondary. Bone Neoplasms / secondary. Fracture Fixation, Intramedullary / adverse effects. Tibia. Tibial Fractures / surgery
  • [MeSH-minor] Aged. Female. Fracture Healing. Humans. Lung Neoplasms / diagnosis. Male. Middle Aged

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  • (PMID = 21037359.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
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15. Ozcanli H, Ozdemir H, Ozenci AM, Söyüncü Y, Aydin AT: [Metastatic tumors of the hand in three cases]. Acta Orthop Traumatol Turc; 2005;39(5):445-8
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  • [Title] [Metastatic tumors of the hand in three cases].
  • Metastatic malignancies of the hand are rare and they usually develop from lung, breast, and kidney tumors.
  • We presented three patients with metastatic tumors of the hand, whose ages were 58 (male), 42 (female), and 40 (male) years.
  • Metastases developed in the thumb and the big toe, metacarpal bone, and the nail bed following treatment for primary tumors of the bladder, colon, and chondrosarcoma of the proximal femur, respectively.
  • [MeSH-major] Adenocarcinoma / diagnosis. Bone Neoplasms / diagnosis. Hand
  • [MeSH-minor] Adult. Colonic Neoplasms / diagnosis. Colonic Neoplasms / pathology. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. Urinary Bladder Neoplasms / diagnosis. Urinary Bladder Neoplasms / pathology

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  • (PMID = 16531705.001).
  • [ISSN] 1017-995X
  • [Journal-full-title] Acta orthopaedica et traumatologica turcica
  • [ISO-abbreviation] Acta Orthop Traumatol Turc
  • [Language] tur
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Turkey
  • [Number-of-references] 25
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16. Uruga H, Morokawa N, Enomoto T, Takaya H, Miyamoto A, Kishi K, Kurosaki A, Fujii T, Yoshimura K: [A case of pulmonary tumor thrombotic microangiopathy associated with lung adenocarcinoma diagnosed by CT-guided lung biopsy]. Nihon Kokyuki Gakkai Zasshi; 2008 Nov;46(11):928-33
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  • [Title] [A case of pulmonary tumor thrombotic microangiopathy associated with lung adenocarcinoma diagnosed by CT-guided lung biopsy].
  • CT-guided lung biopsy from the right lower lobe revealed tumor cell embolism, intimal fibrocellular proliferation of small arteries, fibrin thrombi and recanalization.
  • Embolic tumor cells were adenocarcinoma and immunohistologial staining for TTF-1 was positive.
  • The patient was diagnosed as having pulmonary tumor thrombotic microangiopathy (PTTM) associated with clinical stage IV primary lung adenocarcinoma.
  • Although chemotherapy with carboplatin and paclitaxel resulted in improvement of pulmonary consolidations, multiple bone metastatic lesions appeared.
  • This was the first reported case of PTTM associated with lung cancer and diagnosed antemortem by CT-guided biopsy.
  • This suggests that CT-guided lung biopsy may be useful for diagnosis of PTTM, and enable establishment of appropriate cancer chemotherapy.
  • [MeSH-major] Adenocarcinoma / pathology. Biopsy / methods. Lung / blood supply. Lung Neoplasms / pathology. Neoplastic Cells, Circulating / pathology. Tomography, X-Ray Computed

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  • (PMID = 19068768.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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17. Ahlmann ER, Greene NW, Menendez LR, Stevanovic MV: Unusual locations for metastatic malignancy of the hand: a report of three cases. J Surg Orthop Adv; 2008;17(4):267-70
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  • [Title] Unusual locations for metastatic malignancy of the hand: a report of three cases.
  • Metastatic tumors of the hand bones are very rare.
  • This report presents three cases of metastatic lesions involving the bones of the hand.
  • These metastases, with adenocarcinoma of the lung as the primary malignancy, were the first clinical presentation of adenocarcinoma in two of these patients.
  • The hamate bone was involved in one patient and the proximal phalanx of the ring finger was involved in the other patient.
  • The third patient developed metastatic disease to the distal phalanx 8 months after initial diagnosis.
  • The authors emphasize that a lytic lesion in the hand may be the first clinical sign of a malignancy or progression to metastatic disease.
  • [MeSH-major] Adenocarcinoma / pathology. Bone Neoplasms / secondary. Finger Phalanges. Hamate Bone. Lung Neoplasms / pathology

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  • (PMID = 19138500.001).
  • [ISSN] 1548-825X
  • [Journal-full-title] Journal of surgical orthopaedic advances
  • [ISO-abbreviation] J Surg Orthop Adv
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Husain A, Blumenschein G, Esmaeli B: Treatment and outcomes for metastatic sebaceous cell carcinoma of the eyelid. Int J Dermatol; 2008 Mar;47(3):276-9
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  • [Title] Treatment and outcomes for metastatic sebaceous cell carcinoma of the eyelid.
  • OBJECTIVE: To report the management and outcomes in patients with metastatic eyelid sebaceous cell carcinoma.
  • METHODS: The clinical records of four patients with metastatic eyelid sebaceous cell carcinoma treated between January 1999 and August 2006 were reviewed.
  • Metastatic sites included the lung in three patients, regional lymph nodes in two, liver in two, and bone in one.
  • Time from diagnosis of eyelid carcinoma to metastasis ranged from 0 to 62 months.
  • One patient developed lung metastasis 5 years after the diagnosis of eyelid tumor; she was treated with systemic chemotherapy followed by subtotal lung resection.
  • The follow-up time from diagnosis of metastasis to last contact or death ranged from 1 month to 3 years (median of 21 months).
  • Treatment of metastatic disease may include a combination of chemotherapy, radiation, and surgical neck dissection.
  • [MeSH-major] Adenocarcinoma, Sebaceous / secondary. Bone Neoplasms / secondary. Eyelid Neoplasms / pathology. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Parotid Neoplasms / secondary. Sebaceous Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma, Basal Cell / diagnosis. Chalazion / diagnosis. Diagnostic Errors. Female. Humans. Lymphatic Metastasis / radiotherapy. Middle Aged. Retrospective Studies

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  • (PMID = 18289332.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Yasar F, Oz G, Dolanmaz D, Akgünlü F: Mandibular metastasis in a patient with pulmonary adenocarcinoma. Dentomaxillofac Radiol; 2006 Sep;35(5):383-5
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  • [Title] Mandibular metastasis in a patient with pulmonary adenocarcinoma.
  • Metastatic tumour spread to the mandible is quite rare.
  • We report a case of distant metastasis of pulmonary adenocarcinoma in the mandibular bone.
  • The patient had pain in his left mandibular premolar-molar area caused by a mandibular metastasis from a previously undiagnosed pulmonary adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Lung Neoplasms / pathology. Mandibular Neoplasms / secondary
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male

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  • (PMID = 16940489.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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20. Anoop TM, George S, Divya KP, Jabbar PK: Metastatic phalangeal osteolysis as an initial presentation of carcinoma colon. Am J Surg; 2010 Nov;200(5):e61-3
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  • [Title] Metastatic phalangeal osteolysis as an initial presentation of carcinoma colon.
  • Metastatic malignancies of the hand are rare and usually develop from lung, breast, or kidney tumors.
  • The authors report a case of differentiated adenocarcinoma of the colon in a 76-year-old man who presented with distal phalangeal metastasis and osteolysis in the form of a painful swelling at the tip of the right little finger of 6 months duration.
  • Diagnosis was confirmed by biopsy.
  • [MeSH-major] Adenocarcinoma / secondary. Bone Neoplasms / secondary. Colonic Neoplasms / pathology. Finger Phalanges. Osteolysis / etiology
  • [MeSH-minor] Aged. Biopsy. Diagnosis, Differential. Fatal Outcome. Humans. Male. Tomography, X-Ray Computed

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20870210.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. Delgado-López PD, Martín-Velasco V, Castilla-Díez JM, Fernández-Arconada O, Corrales-García EM, Galacho-Harnero A, Rodríguez-Salazar A, Pérez-Mies B: Metastatic meningioma to the eleventh dorsal vertebral body: total en bloc spondylectomy. Case report and review of the literature. Neurocirugia (Astur); 2006 Jun;17(3):240-9
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  • [Title] Metastatic meningioma to the eleventh dorsal vertebral body: total en bloc spondylectomy. Case report and review of the literature.
  • Lung and intraabdominal organs are most frequently affected.
  • To our knowledge, this is the first description of a total en bloc spondylectomy through a posterior approach for the treatment of an intraosseous metastatic meningioma to the eleventh dorsal vertebra.
  • The pathological specimen was identified as adenocarcinoma and he initiated chemotherapy.
  • Advice from a second pathologist was seeked, who suggested the diagnosis of intraosseous meningioma.
  • In May 2004 the patient was admitted to our department and a new transpedicular biopsy confirmed the diagnosis.
  • In June 2004 he underwent T11 total en bloc spondylectomy (Tomita's procedure), fusion with bone and calcium substitute-filled stackable carbon-fiber cages, and T9 to L1 transpedicular screw fixation.

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  • (PMID = 16855782.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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22. Kreusel KM, Bechrakis NE, Wiegel T, Krause L, Foerster MH: Incidence and clinical characteristics of symptomatic choroidal metastasis from lung cancer. Acta Ophthalmol; 2008 Aug;86(5):515-9
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  • [Title] Incidence and clinical characteristics of symptomatic choroidal metastasis from lung cancer.
  • PURPOSE: To determine the clinical characteristics of symptomatic choroidal metastasis (CM) resulting from metastatic lung cancer.
  • METHODS: Twenty-two consecutive patients with symptomatic CM resulting from lung cancer were retrospectively reviewed for ocular findings, medical history and systemic disease.
  • All patients underwent a complete screening for further organ metastasis by computed tomography (CT) and bone scintigraphy.
  • RESULTS: In eight of 22 (36%; 95% confidence interval [CI] 17-59) patients, lung cancer had been diagnosed before occurrence of CM, with a median interval of 13 months.
  • In 14 patients lung cancer was detected after diagnosis of CM, with a median interval of 1 month.
  • Median survival after diagnosis of symptomatic CM was 13 months, by contrast with 2 months in lung cancer patients with CM identified in an ocular screening study.
  • CONCLUSIONS: Symptomatic choroidal lung cancer metastasis in the majority of patients presents as a solitary tumour before diagnosis of lung cancer in patients with multiple organ systems affected by metastatic disease.
  • [MeSH-major] Choroid Neoplasms / secondary. Lung Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / epidemiology. Adenocarcinoma / secondary. Adult. Aged. Carcinoid Tumor / diagnosis. Carcinoid Tumor / epidemiology. Carcinoid Tumor / secondary. Carcinoma, Large Cell / diagnosis. Carcinoma, Large Cell / epidemiology. Carcinoma, Large Cell / secondary. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / secondary. Female. Humans. Incidence. Male. Middle Aged. Positron-Emission Tomography. Retrospective Studies. Small Cell Lung Carcinoma / diagnosis. Small Cell Lung Carcinoma / epidemiology. Small Cell Lung Carcinoma / secondary. Tomography, X-Ray Computed

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  • (PMID = 18081901.001).
  • [ISSN] 1755-3768
  • [Journal-full-title] Acta ophthalmologica
  • [ISO-abbreviation] Acta Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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23. Lasithiotakis K, Petrakis I, Georgiadis G, Paraskakis S, Chalkiadakis G, Chrysos E: Pancreatic resection for metastasis to the pancreas from colon and lung cancer, and osteosarcoma. JOP; 2010;11(6):593-6
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  • [Title] Pancreatic resection for metastasis to the pancreas from colon and lung cancer, and osteosarcoma.
  • CONTEXT: Pancreatic resection for a metastatic colon, lung cancer or an osteosarcoma has rarely been reported in the literature and there is controversy regarding recurrence and the overall survival of these patients.
  • We herein evaluate the outcome of three patients who underwent pancreaticoduodenectomy for the aforementioned metastatic tumors to the pancreas.
  • All the pancreatic lesions were located in the head of the pancreas, and the intervals between the diagnosis of the primary cancer and the pancreatic metastases were 6, 14 and 24 months.
  • During exploration of the abdomen, additional metastatic lesions in the small intestine and liver were detected and resected in two patients.
  • CONCLUSION: Pancreatic resection for metastatic disease may be suggested for selected patients, even those with limited extrapancreatic disease.
  • [MeSH-major] Bone Neoplasms / pathology. Colonic Neoplasms / pathology. Lung Neoplasms / pathology. Osteosarcoma / pathology. Pancreatic Neoplasms / secondary. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adolescent. Female. Humans. Male. Middle Aged. Pancreatectomy / methods


24. Ramkumar U, Munshi NI, El-Jabbour JN: Occult carcinoma of the lung presenting as pain in the hallux: a case report. J Foot Ankle Surg; 2005 Nov-Dec;44(6):483-6
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  • [Title] Occult carcinoma of the lung presenting as pain in the hallux: a case report.
  • Metastatic tumors to the hands and feet (acrometastases) are rare.
  • We report a case in which the primary presentation of a lung carcinoma was a metastatic lesion to the distal phalanx of the hallux.
  • Radiographs and computed tomography suggested a benign lesion in the distal phalanx of the hallux, but curettage and biopsy revealed metastatic adenocarcinoma.
  • A chest x-ray revealed a mass in the right perihilar region, which was confirmed by CT, bronchoscopy, and biopsy as carcinoma of the lung.
  • A review of the literature reveals that there is a tendency toward delayed diagnosis in similar cases, especially when the primary lesion is asymptomatic.
  • A high index of suspicion is needed for early diagnosis in such cases.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Bone Neoplasms / secondary. Hallux / pathology. Lung Neoplasms / diagnosis

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  • (PMID = 16257681.001).
  • [ISSN] 1067-2516
  • [Journal-full-title] The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
  • [ISO-abbreviation] J Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Mitsuhashi T, Shimizu Y, Ban S, Ogawa F, Hirose T, Tanaka J, Shimizu M: Multicentric contiguous variant of epithelioid angiosarcoma of the bone. A rare variant showing angiotropic spread. Ann Diagn Pathol; 2005 Feb;9(1):33-7
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  • [Title] Multicentric contiguous variant of epithelioid angiosarcoma of the bone. A rare variant showing angiotropic spread.
  • Epithelioid angiosarcoma of the bone is a rare tumor and is a diagnostic challenge.
  • The initial diagnosis of a tibial biopsy was poorly differentiated adenocarcinoma.
  • On the occasion of autopsy, a fungating thrombotic nodule was found at the anterior wall of the right atrium, and small hemorrhagic infarcts with tumor thrombi were found in the lung.
  • This case showed angiotropic spread of the tumor only to the right atrium and the lung, with no solid mass in other organs.
  • Multicentric epithelioid angiosarcoma of the bone is a pitfall in pathological diagnoses, especially if a strong radiological impression of metastatic carcinoma is provided.
  • [MeSH-major] Bone Neoplasms / pathology. Epithelioid Cells / pathology. Hemangiosarcoma / secondary. Neoplasms, Multiple Primary / pathology
  • [MeSH-minor] Adenocarcinoma / diagnosis. Antigens, CD31 / analysis. Biomarkers, Tumor / analysis. Biopsy. Diagnosis, Differential. Fatal Outcome. Humans. Immunohistochemistry. Keratins / analysis. Male. Middle Aged. Neoplasm Invasiveness / pathology. Tibia / pathology. Vimentin / analysis. von Willebrand Factor / analysis

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  • (PMID = 15692948.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Biomarkers, Tumor; 0 / Vimentin; 0 / von Willebrand Factor; 68238-35-7 / Keratins
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26. Destombe C, Botton E, Le Gal G, Roudaut A, Jousse-Joulin S, Devauchelle-Pensec V, Saraux A: Investigations for bone metastasis from an unknown primary. Joint Bone Spine; 2007 Jan;74(1):85-9
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  • [Title] Investigations for bone metastasis from an unknown primary.
  • OBJECTIVES: To evaluate the respective contributions of various investigations used to identify the primary tumor in a cohort of patients referred for diagnostic evaluation of one or more bone metastases.
  • METHODS: A single-center retrospective study was conducted in a cohort of patients admitted between October 1990 and January 2000 for evaluation of one or more bone metastases with no known primary.
  • All patients underwent radionuclide bone scanning, a chest radiograph, and an abdominal ultrasound scan.
  • Using the final diagnosis as the reference standard, we evaluated the diagnostic usefulness of each investigation.
  • The primary was located in the lung in 37 patients, prostate in 26, breast or female genital tract in 24, urinary system in 11, gastrointestinal tract in 11, head and neck in 6, and other organs in 4.
  • The extraskeletal metastases were located chiefly in the liver (20.4%), lung (17.1%), pleura (13.2%), and brain (7.2%).
  • Bone biopsies were performed in 107 patients: 84 had a single bone biopsy, 16 had two bone biopsies, and 7 had three bone biopsies.
  • The first bone biopsy was taken in the rheumatology department with or without fluoroscopic guidance in 62 patients, in the radiology department under CT guidance in 6 patients, and in the surgery department in 32 patients; this information was unavailable for the 7 remaining patients.
  • The first bone biopsy was taken from the iliac bone in 48 patients, spine in 32, sacrum in 10, rib in 3, and other sites in 7.
  • The histological biopsy findings indicated adenocarcinoma in 58 cases, epidermoid carcinoma in 28 cases, undifferentiated carcinoma in 2 cases, and other histological patterns in 9 cases.
  • In 80 patients, another metastatic site was easier to access than the bone metastasis.
  • CONCLUSION: Bone biopsies performed by rheumatologists, generally under fluoroscopic guidance, usually indicate the site of the primary or at least the histological type.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bone Neoplasms / secondary. Neoplasms, Unknown Primary / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor. Biopsy. Bone and Bones / pathology. Breast Neoplasms / diagnosis. Breast Neoplasms / pathology. Cohort Studies. Diagnostic Imaging. Female. Humans. Lung Neoplasms / diagnosis. Lung Neoplasms / pathology. Male. Middle Aged. Retrospective Studies. Sensitivity and Specificity. Urogenital Neoplasms / diagnosis. Urogenital Neoplasms / pathology

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  • [CommentIn] Joint Bone Spine. 2008 Jan;75(1):100; author reply 100-1 [18083617.001]
  • (PMID = 17218141.001).
  • [ISSN] 1778-7254
  • [Journal-full-title] Joint, bone, spine : revue du rhumatisme
  • [ISO-abbreviation] Joint Bone Spine
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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27. Sundermeyer ML, Meropol NJ, Rogatko A, Wang H, Cohen SJ: Changing patterns of bone and brain metastases in patients with colorectal cancer. Clin Colorectal Cancer; 2005 Jul;5(2):108-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Changing patterns of bone and brain metastases in patients with colorectal cancer.
  • BACKGROUND: Therapeutic advances for patients with metastatic colorectal cancer (CRC) have been associated with prolonged survival.
  • This study was undertaken to test the hypothesis that expanded treatment options and resultant improved survival for patients with metastatic CRC are associated with an increased incidence of metastases at uncommon sites.
  • PATIENTS AND METHODS: Patients with metastatic CRC evaluated from 1993 to 2002 at the Fox Chase Cancer Center were identified.
  • Medical records were abstracted to obtain the following: date of diagnosis/metastasis, primary tumor site, therapeutic agents received, survival, and site(s) of metastases.
  • Incidence of bone and brain metastases were 10.4% (95% CI, 8.6%-12.4%) and 3% (95% CI, 2.2%-4.5%), respectively.
  • Bone metastases were more common with increased numbers of active systemic agents received: 0 (3.7%), 1 (9.4%), 2 (10.9%), 3 (16.3%), and 4/5 (17.4%; P = 0.001; trend test).
  • Patients receiving irinotecan or oxaliplatin were more likely to develop bone metastases (13.2% vs. 8.3%, P = 0.01 for irinotecan; 16.9% vs. 9%, P = 0.003 for oxaliplatin).
  • Patients with primary rectal versus primary colon cancer were more likely to develop bone metastases (16% vs. 8.6%; P = 0.001).
  • Patients with lung metastases were more likely to have bone metastases (16.1% vs. 6.4%; P < 0.0001) or brain metastases (6.2% vs. 1.2%; P < 0.0001) than those without.
  • CONCLUSION: These data demonstrate that the incidence of bone and brain metastases in patients with CRC is more common than previously reported and is associated with receipt of multiple systemic treatments.
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenocarcinoma / secondary. Bone Neoplasms / epidemiology. Bone Neoplasms / secondary. Brain Neoplasms / epidemiology. Brain Neoplasms / secondary. Colorectal Neoplasms / pathology


28. Inaoka T, Takahashi K, Aburano T, Miyokawa N, Tandai S, Kobayashi T, Matsuno T: Spinal metastasis from lung cancer fifteen years after surgery presenting a pseudohemangioma appearance of the vertebra: a case report. Spine (Phila Pa 1976); 2010 Feb 1;35(3):E86-9
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  • [Title] Spinal metastasis from lung cancer fifteen years after surgery presenting a pseudohemangioma appearance of the vertebra: a case report.
  • OBJECTIVE: To describe a case of solitary metastasis of the seventh thoracic vertebra (T7) from lung cancer 15 years after surgery.
  • SUMMARY OF BACKGROUND DATA: Late recurrence of the bone over 5 years after curative surgery for lung cancer is highly exceptional.
  • In addition, bone metastasis from lung cancer showing a coarse trabecular pattern of the vertebra on computed tomography (CT) is quite unusual.
  • METHODS: A case of solitary metastasis of T7 from lung cancer 15 years after surgery showing a pseudohemangioma appearance of the vertebra on CT is presented.
  • He had undergone a left lower lobectomy for lung cancer 15 years previously.
  • No other lesion was detected by whole-body CT and bone scintigraphy.
  • Tumor resection and T5-T9 posterior spinal fusion had been performed, and a pathologic diagnosis of metastatic pulmonary adenocarcinoma of the bone was established.
  • CONCLUSION: We have reported a rare case of solitary metastasis to T7 appearing 15 years after surgery for lung cancer.
  • The incidence of lung cancer recurrence more than 5 years after surgery is exceedingly low; however, even in patients with lung cancer, late occurrence of bone metastasis should be considered and included in the differential diagnosis of a pseudohemangioma appearance of the vertebra.
  • [MeSH-major] Hemangioma / radiography. Lung Neoplasms / radiography. Spinal Neoplasms / radiography. Spinal Neoplasms / secondary. Thoracic Vertebrae / radiography
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male. Time Factors

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  • (PMID = 20075786.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Tamiolakis D, Tsamis I, Thomaidis V, Lambropoulou M, Alexiadis G, Venizelos I, Jivanakis T, Papadopoulos N: Oral complaints caused from metastases to the mandible and maxilla. Chirurgia (Bucur); 2007 Jul-Aug;102(4):439-42

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  • Jaw bone disorders causing oral complaints are common in primary care settings.
  • However they also may be the symptoms of a primary or secondary malignant process in the bone.
  • The most common malignant bone tumor is metastatic carcinoma, and tumors arising in the breast, prostate, thyroid, lung and kidney have a special propensity to spread to bone.
  • We describe four cases of metastatic tumours to the jaws.
  • Physicians who frequently advise patients with oral complaints should keep in mind that whereas these symptoms are mostly of a chronic and benign nature, metastases from a malignant tumor must be included in the differential diagnosis.
  • [MeSH-major] Adenocarcinoma / secondary. Facial Pain / etiology. Mandibular Neoplasms / secondary. Maxillary Neoplasms / secondary
  • [MeSH-minor] Aged. Diagnosis, Differential. Esophageal Neoplasms / pathology. Female. Humans. Liver Neoplasms / pathology. Male. Medical Records. Middle Aged. Retrospective Studies. Survival Rate. Thyroid Neoplasms / pathology. Treatment Outcome

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  • (PMID = 17966942.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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30. Pentheroudakis G, Golfinopoulos V, Pavlidis N: Switching benchmarks in cancer of unknown primary: from autopsy to microarray. Eur J Cancer; 2007 Sep;43(14):2026-36
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Published reports on identification of CUP primary site by autopsy or microarray-based multigene expression platforms were retrieved and analysed for year of publication, primary site, patient age, gender, histology, rate of primary identification, manifestations and metastatic deposits, microarray chip technology, training and validation sets, mathematical modelling, classification accuracy and number of classifying genes.
  • RESULTS: From 1944 to 2000, a total of 884 CUP patients (66% males) underwent autopsy in 12 studies after presenting with metastatic or systemic symptoms and succumbing to their disease.
  • A primary was identified in 644 (73%) of them, mostly in the lung (27%), pancreas (24%), hepatobiliary tree (8%), kidneys (8%), bowel, genital system and stomach, as a small focus of adenocarcinoma or poorly differentiated carcinoma.
  • An unpredictable systemic dissemination was evident with high frequency of lung (46%), nodal (35%), bone (17%), brain (16%) and uncommon (18%) deposits.
  • Between the 1944-1980 and the 1980-2000 series, female representation increased, 'undetermined neoplasm' diagnosis became rarer, pancreatic primaries were found less often while colonic ones were identified more frequently.
  • Four studies using microarray technology profiled more than 500 CUP cases using classifier set of genes (ranging from 10 to 495) and reported strikingly dissimilar frequencies of assigned primary sites (lung 11.5%, pancreas 12.5%, bowel 12%, breast 15%, hepatobiliary tree 8%, kidneys 6%, genital system 9%, bladder 5%) in 75-90% of the cases.
  • Discrepant assignment of primary sites by microarrays may be due to the presence of 'sanctuary sites' in autopsies, molecular misclassification and the postulated presence of a pro-metastatic genetic signature.
  • [MeSH-major] Microarray Analysis / methods. Neoplasms, Unknown Primary / diagnosis

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  • (PMID = 17698346.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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31. Eroglu A, Karaoglanoglu N, Bilen H, Gursan N: Follicular thyroid carcinoma: metastasis to the sternum, 13 years after total thyroidectomy. Int J Clin Pract; 2006 Nov;60(11):1506-8
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  • Primary and metastatic malignancies of the sternum are uncommon.
  • Secondary lesions to the sternum occur more commonly in patients with lung and breast cancer, and only a few cases of sternal metastasis arising from a follicular thyroid carcinoma have been reported in the literature.
  • Rarely, metastases to the sternum present in the guise of primary sternal tumours may be treated surgically with that diagnosis in mind.
  • Late metastatic thyroid carcinoma to the sternum should be kept in mind in the differential diagnosis of sternal lesions.
  • [MeSH-major] Adenocarcinoma, Follicular / secondary. Bone Neoplasms / secondary. Sternum. Thyroid Neoplasms

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  • [CommentIn] Int J Clin Pract. 2007 Mar;61(3):521; author reply 521-2 [17313627.001]
  • (PMID = 17073845.001).
  • [ISSN] 1368-5031
  • [Journal-full-title] International journal of clinical practice
  • [ISO-abbreviation] Int. J. Clin. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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32. Tamura M, Dohhba S, Funaki K, Sasaki S, Michiwa Y, Kurosaka Y, Takekawa S, Kiriyama M, Kojima Y, Kita T: [Pulmonary pleomorphic carcinoma; report of 2 cases]. Kyobu Geka; 2006 Jul;59(7):585-9
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  • Biopsy of the bone revealed metastatic adenocarcinoma.
  • With a diagnosis of primary lung cancer (cT2N1M1), two-staged operation was performed.
  • Pathological diagnosis was pleomorphic carcinoma [pT2N1M1 (OSS), stage IV].
  • Chest CT revealed a tumor in the right hilar region, which was diagnosed as adenocarcinoma by transbronchial lung biopsy.
  • Autopsy revealed pleomorphic carcinoma of the lung with metastasis to the brain, costa and mediastinal lymph nodes.
  • [MeSH-major] Adenocarcinoma / radiography. Carcinoma / radiography. Lung Neoplasms / radiography

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  • (PMID = 16856536.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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33. Currall VA, Dixon JH: Synovial metastasis: an unusual cause of pain after total knee arthroplasty. J Arthroplasty; 2008 Jun;23(4):631-6
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  • Synovial biopsy revealed metastatic adenocarcinoma of colorectal type.
  • The knee is the most frequently affected joint, and the lung is the most common primary site for synovial metastasis.
  • This phenomenon should be considered in the differential diagnosis of continuing pain and effusion postarthroplasty.
  • [MeSH-major] Adenocarcinoma / secondary. Arthroplasty, Replacement, Knee. Bone Neoplasms / secondary. Colorectal Neoplasms / diagnosis. Joint Diseases / diagnosis. Knee Joint. Pain, Postoperative / etiology. Synovial Membrane
  • [MeSH-minor] Aged. Arthroscopy. Biopsy. Diagnosis, Differential. Humans. Male. Neoplasm Recurrence, Local / pathology. Osteoarthritis, Knee / surgery

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  • (PMID = 18514889.001).
  • [ISSN] 0883-5403
  • [Journal-full-title] The Journal of arthroplasty
  • [ISO-abbreviation] J Arthroplasty
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Bergmann I, Weiss M, Schaffner T: [Pulmonary microscopic tumor embolism syndrome]. Dtsch Med Wochenschr; 2006 Mar 24;131(12):618-21
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  • INVESTIGATIONS: Investigations revealed an adenocarcinoma of the colon with retroperitoneal, mediastinal and supraclavicular lymph node metastasis and poorly differentiated carcinoma of the prostate with extensive bone metastases.
  • DIAGNOSIS, TREATMENT AND COURSE: During the following days the patients condition deteriorated further and both patients' died from irreversible right heart failure.
  • Both autopsies showed extensive metastatic adenocarcinoma with marked angiosis carcinomatosa of the lungs with numerous occlusions of small arteries and arterioles and resulting cor pulmonale.
  • [MeSH-major] Adenocarcinoma / secondary. Colonic Neoplasms / pathology. Lung Neoplasms / secondary. Neoplastic Cells, Circulating / pathology. Prostatic Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Echocardiography. Fatal Outcome. Female. Humans. Hypertension, Pulmonary / diagnosis. Hypertension, Pulmonary / etiology. Hypertension, Pulmonary / pathology. Immunohistochemistry. Lymphatic Metastasis. Male. Middle Aged. Pulmonary Embolism / diagnosis. Pulmonary Heart Disease / etiology. Syndrome

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  • (PMID = 16544237.001).
  • [ISSN] 0012-0472
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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35. Parvez T, Ibraheim MI: Diagnostic and prognostic yield of tumor markers in cancer of unknown primary site. J Coll Physicians Surg Pak; 2006 Feb;16(2):154-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A case of metastatic carcinoma of unknown primary is reported that had widely disseminated disease from the very outset.
  • It was assumed that lung was the most possible site for primary.
  • [MeSH-major] Adenocarcinoma / secondary. Biomarkers, Tumor / blood. Bone Neoplasms / secondary. CA-125 Antigen / blood. Lung Neoplasms / secondary. Neoplasms, Unknown Primary / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Humerus. Lumbar Vertebrae. Prognosis. Ribs

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  • (PMID = 16499817.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-125 Antigen
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36. Cardenas MG, Kini S, Wisgerhof M: Two patients with highly aggressive macrofollicular variant of papillary thyroid carcinoma. Thyroid; 2009 Apr;19(4):413-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report two patients with highly aggressive MFV-PTC including bone metastases, one of whom died of their disease.
  • There were multiple bone lesions on computed tomography.
  • The second patient was an 81-year-old man with a history of right thyroid nodule treated by total thyroidectomy with a postoperative diagnosis of adenomatous goiter.
  • The patient developed new bone and lung metastases.
  • He died of metastatic thyroid cancer.
  • CONCLUSIONS: To our knowledge these are the first cases of MFV-PTC reported with bone metastasis.
  • [MeSH-major] Adenocarcinoma, Papillary / diagnosis. Bone Neoplasms / secondary. Carcinoma, Papillary / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Fatal Outcome. Female. Humans. Male. Middle Aged. Thyroid Nodule / diagnosis. Thyroid Nodule / pathology

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  • (PMID = 19355832.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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37. Sakai T, Kimura D, Hatanaka R, Yamada Y, Tsushima T, Fukuda I, Kamata Y: [Surgical treated pulmonary metastasis from prostatic cancer; report of a case]. Kyobu Geka; 2010 Apr;63(4):340-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Computed tomography showed solitary tumor in the lower lobe of the left lung.
  • Transbronchial lung biopsy revealed pulmonary metastasis form prostatic cancer.
  • Because no other metastatic lesions were detected, the patient underwent surgery for pulmonary lesion.
  • The wedge resection of the left lung was performed.
  • Microscopically, the diagnosis of pulmonary and multiple pleural metastases was established.
  • The pulmonary metastasis without bone nor lymph node metastasis is rare.
  • [MeSH-major] Adenocarcinoma / secondary. Lung Neoplasms / secondary. Pleural Neoplasms / secondary. Prostatic Neoplasms / pathology

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  • (PMID = 20387512.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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38. Liou MJ, Lin JD, Chung MH, Liau CT, Hsueh C: Renal metastasis from papillary thyroid microcarcinoma. Acta Otolaryngol; 2005 Apr;125(4):438-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Distant metastasis caused by thyroid microcarcinoma is uncommon, and is usually found in the lung or bone.
  • Clinically detectable well-differentiated metastatic thyroid carcinoma to the kidney is rare, and only 16 cases have been reported.
  • Herein we describe a case of metastatic papillary thyroid microcarcinoma to the kidney in a patient with a pelvic fracture and pulmonary metastasis.
  • [MeSH-major] Adenocarcinoma, Follicular / secondary. Adenocarcinoma, Papillary / secondary. Kidney Neoplasms / secondary. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Bone Neoplasms / diagnosis. Bone Neoplasms / pathology. Bone Neoplasms / secondary. Calcinosis / diagnosis. Calcinosis / pathology. Disease Progression. Female. Humans. Lung Neoplasms / diagnosis. Lung Neoplasms / pathology. Lung Neoplasms / secondary. Middle Aged. Pelvic Bones / pathology. Thyroglobulin / blood. Thyroid Gland / pathology. Tomography, X-Ray Computed. Ultrasonography

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  • (PMID = 15823819.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 9010-34-8 / Thyroglobulin
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39. VanWye WR: Patient screening by a physical therapist for nonmusculoskeletal hip pain. Phys Ther; 2009 Mar;89(3):248-56
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Hip pain is a common complaint addressed by physical therapists; therefore, it would be advantageous for them to be knowledgeable about differential diagnosis for hip pain, so that they can screen for possible serious conditions outside the realm of physical therapist practice and make the appropriate referral.
  • OUTCOMES: The patient was diagnosed later with primary lung adenocarcinoma with widespread metastases.
  • A computerized tomography scan of the left hip revealed a metastatic lesion at the left proximal femur.
  • DISCUSSION: Physical therapists' ability to adequately screen for conditions requiring examination by a physician can lead to a more timely diagnosis of serious medical conditions.
  • [MeSH-major] Arthralgia / etiology. Bone Neoplasms / complications. Hip Joint. Lung Neoplasms / complications. Physical Therapy Modalities. Referral and Consultation
  • [MeSH-minor] Aged. Humans. Male. Osteoarthritis / diagnosis

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  • (PMID = 19168712.001).
  • [ISSN] 1538-6724
  • [Journal-full-title] Physical therapy
  • [ISO-abbreviation] Phys Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Tirabosco R, Lang-Lazdunski L, Diss TC, Amary MF, Rodriguez-Justo M, Landau D, Lorenzi W, Flanagan AM: Clear cell sarcoma of the mediastinum. Ann Diagn Pathol; 2009 Jun;13(3):197-200
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  • At thoracotomy, the mass was found tightly adherent to the esophageal wall and right lower lobe of the lung.
  • The diagnosis of clear cell sarcoma was supported by demonstrating the presence of an EWS gene rearrangement by fluorescence in situ hybridization.
  • There was no evidence that this lesion represented metastatic disease.
  • We present the case and discuss the differential diagnosis.
  • [MeSH-minor] Adenocarcinoma / pathology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Bone Neoplasms / drug therapy. Bone Neoplasms / secondary. Diagnosis, Differential. Female. Gastrointestinal Stromal Tumors / pathology. Gene Rearrangement. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Lymphatic Metastasis / pathology. Middle Aged. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 19433300.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA-Binding Protein EWS
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41. Lukaszewska J, Lewandowski K: Cabot rings as a result of severe dyserythropoiesis in a dog. Vet Clin Pathol; 2008 Jun;37(2):180-3

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  • An 11-year-old female Dachshund was presented with depression, diarrhea, weight loss, and radiographic evidence of masses involving the liver, spleen, and cranial lobe of the right lung.
  • Bone marrow aspirate and core biopsy specimens obtained at the time of euthanasia revealed marked dysplastic changes in all cell lines, especially dyserythropoiesis, along with infiltrating carcinoma cells.
  • A necropsy was performed, and histologic examination revealed poorly differentiated adenocarcinoma of the lung with multiple metastases to the marrow, spleen, and liver.
  • The final diagnosis was marked myelodysplasia secondary to metastatic adenocarcinoma.

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  • (PMID = 18533917.001).
  • [ISSN] 0275-6382
  • [Journal-full-title] Veterinary clinical pathology
  • [ISO-abbreviation] Vet Clin Pathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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42. Spiteri V, Bibra A, Ashwood N, Cobb J: Managing acrometastases treatment strategy with a case illustration. Ann R Coll Surg Engl; 2008 Oct;90(7):W8-11
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  • Frequently, these lesions present in a similar way to benign conditions leading to erroneous diagnosis and inappropriate treatment.
  • When located in the finger, the most frequent cause is lung cancer, while in the toes it is due to genito-urinary tumours.
  • Awareness of the possibility of metastatic disease during orthopaedic assessment is essential to decrease patient morbidity.
  • A case that was referred to our institution with a single metastasis in a digit from occult gastric adenocarcinoma is used to illustrate the way these lesions are managed.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Fingers. Skin Neoplasms / secondary. Stomach Neoplasms

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  • (PMID = 18831862.001).
  • [ISSN] 1478-7083
  • [Journal-full-title] Annals of the Royal College of Surgeons of England
  • [ISO-abbreviation] Ann R Coll Surg Engl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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43. Pallini R, Sabatino G, Doglietto F, Lauretti L, Fernandez E, Maira G: Clivus metastases: report of seven patients and literature review. Acta Neurochir (Wien); 2009 Apr;151(4):291-6; discussion 296

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • FINDINGS: Of 46 patients who underwent surgery for clivus bone tumours, seven proved to harbour a metastasis.
  • The primary tumours associated were lung adenocarcinoma (n = 2), prostate carcinoma (n = 2), skin melanoma (n = 1), hepatocarcinoma (n = 1) and lung squamous cell carcinoma (n = 1).
  • On literature review, 27 examples of metastases located in the clival bone were found.
  • CONCLUSION: Though exceedingly rare, metastases involving the clivus should be considered in the differential diagnosis with clivus chordoma.
  • The metastatic lesion might be a late and single expression of the primary tumour.
  • The trans-sphenoidal approach is the ideal procedure to establish a histopathological diagnosis.
  • [MeSH-minor] Abducens Nerve Diseases / etiology. Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Liver Neoplasms / pathology. Lung Neoplasms / pathology. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Metastasis. Prognosis. Prostatic Neoplasms / pathology. Skin Neoplasms / pathology. Survival Rate. Tomography, X-Ray Computed

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  • (PMID = 19259614.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Austria
  • [Number-of-references] 30
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44. Pneumaticos SG, Chatziioannou SN, Savvidou C, Pilichou A, Rontogianni D, Korres DS: Routine needle biopsy during vertebral augmentation procedures. Is it necessary? Eur Spine J; 2010 Nov;19(11):1894-8
MedlinePlus Health Information. consumer health - Spine Injuries and Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • All patients received a preoperative workup that included plain radiographs, MRI, whole body bone scan, and laboratory examinations.
  • Bone specimens were obtained from affected vertebral bodies and submitted for histologic evaluation to identify the prevalence of an underlying cause.
  • All specimens demonstrated fragmented bone with variable amounts of unmineralised bone, signs of bone-remodeling and/or fracture-healing.
  • In 11 patients underlying pathology other than osteoporosis was identified (prostate cancer, 1; pancreatic cancer, 1; colon cancer, 1; breast cancer, 2; multiple myeloma, 3; leukemia, 1; and lung cancer, 2).
  • In all but one patient the results of the biopsy confirmed the diagnosis suspected from the preoperative workup.
  • For the last patient, namely the one with pancreatic cancer, the workup did not identify the origin of the primary tumor, although the patient was considered to have a compression fracture secondary to metastatic disease of unknown origin, the vertebral biopsy suggested the presence of adenocarcinoma which eventually was proven to be pancreatic cancer.
  • In augmentation procedures for vertebral compression fractures, bone biopsy should be reserved for the patients where the preoperative evaluation raises the suspicion of a non-osteoporotic etiology.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Bone Neoplasms / complications. Bone Neoplasms / diagnosis. Bone Neoplasms / secondary. Colonic Neoplasms / pathology. Female. Humans. Male. Middle Aged. Osteoporosis / complications. Pancreatic Neoplasms / pathology. Prostatic Neoplasms / pathology

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  • (PMID = 20372942.001).
  • [ISSN] 1432-0932
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2989251
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45. Valdespino-Castillo VE, Ruiz-Jaime A: [Renal cell carcinoma with colon metastases: an infrequent site for metastases]. Cir Cir; 2008 Jul-Aug;76(4):339-42
MedlinePlus Health Information. consumer health - Kidney Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Clear cell carcinoma is the most frequent histological type, and 30% of renal carcinomas have metastasized at the time of diagnosis.
  • CLINICAL CASE: We report the case of a 60-year-old male with a history of metastatic RCC.
  • CONCLUSIONS: RCC metastases are most frequent in lung, liver, and bone and less frequent in brain, skin, and soft tissue.
  • Metastatic clear cell carcinoma requires surgery and immunotherapy.
  • [MeSH-major] Adenocarcinoma, Clear Cell / secondary. Carcinoma, Renal Cell / secondary. Colonic Neoplasms / secondary. Kidney Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Colectomy / methods. Combined Modality Therapy. Follow-Up Studies. Gastrointestinal Hemorrhage / etiology. Humans. Immunotherapy. Interferon-alpha / therapeutic use. Lung Neoplasms / secondary. Male. Middle Aged. Nephrectomy / methods. Remission Induction

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  • (PMID = 18778546.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Interferon-alpha
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46. Ludwick C, Gilks CB, Miller D, Yaziji H, Clement PB: Aggressive behavior of stage I ovarian mucinous tumors lacking extensive infiltrative invasion: a report of four cases and review of the literature. Int J Gynecol Pathol; 2005 Jul;24(3):205-17
MedlinePlus Health Information. consumer health - Ovarian Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Clinical findings supported that they were primary tumors rather than metastatic from an occult primary tumor.
  • On follow-up, each patient experienced recurrent disease 7 months to 4.5 years after diagnosis, including hematogenous spread to lung and/or bone and liver in three patients.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoma in Situ / pathology. Ovarian Neoplasms / pathology

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  • (PMID = 15968194.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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47. Sergieva S, Hadjieva T, Doldurova M, Stefanova S, Dudov A: Nuclear medicine approaches in the monitoring of thyroid cancer patients. J BUON; 2006 Oct-Dec;11(4):511-8
Hazardous Substances Data Bank. THYROGLOBULIN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: (131)I scan was positive in 63 patients showing thyroid remnants in 31 cases, lymph node metastases in 24 cases (17 to the neck, 7 to the neck/mediastinum), pulmonary metastases in 6 cases, bone and brain lesions in 2 cases.
  • These false negative results were observed predominantly in cases with less differentiated metastatic disease, especially after several courses of high-dose (131)I therapy. (99m)Tc-MIBI scan revealed the presence of lymph node and/or lung metastases (non-functioning metastases) in 14 of them, false negative results were obtained in 2 cases, and one false positive in 1 case.
  • [MeSH-minor] Adenocarcinoma, Follicular / radionuclide imaging. Adenocarcinoma, Follicular / therapy. Adult. Aged. Aged, 80 and over. Carcinoma, Papillary / radionuclide imaging. Carcinoma, Papillary / therapy. Female. Follow-Up Studies. Humans. Iodine Radioisotopes / therapeutic use. Lymphatic Metastasis / diagnosis. Magnetic Resonance Imaging. Male. Middle Aged. Neck / ultrasonography. Sensitivity and Specificity. Thyroglobulin / blood. Thyroidectomy. Tomography, X-Ray Computed

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  • (PMID = 17309186.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 0 / Radiopharmaceuticals; 9010-34-8 / Thyroglobulin; 971Z4W1S09 / Technetium Tc 99m Sestamibi
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48. Lim C, Chan R, Regan W: Renal cell carcinoma with cutaneous metastases. Australas J Dermatol; 2005 Aug;46(3):158-60
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Shave biopsies and excisions of the cutaneous lesions revealed findings consistent with metastatic renal cell carcinoma of clear cell type.
  • During this time, metastases to the bone, lung, soft palate and posterior leg were also diagnosed.
  • This case represents an unusual clinical presentation of metastatic renal cell carcinoma.
  • [MeSH-major] Adenocarcinoma, Clear Cell / secondary. Carcinoma, Renal Cell / pathology. Carcinoma, Renal Cell / secondary. Kidney Neoplasms / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Aged. Aged, 80 and over. Ear Neoplasms / diagnosis. Ear Neoplasms / secondary. Ear Neoplasms / therapy. Facial Neoplasms / diagnosis. Facial Neoplasms / secondary. Facial Neoplasms / therapy. Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / secondary. Head and Neck Neoplasms / therapy. Humans. Lip Neoplasms / diagnosis. Lip Neoplasms / secondary. Lip Neoplasms / therapy. Male. Nephrectomy. Treatment Outcome

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  • (PMID = 16008646.001).
  • [ISSN] 0004-8380
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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49. Murguia E, Quiroga D, Canteros G, Sanmartino C, Barreiro M, Herrera J: Gallbladder metastases from ductal papillary carcinoma of the breast. J Hepatobiliary Pancreat Surg; 2006;13(6):591-3
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Breast carcinoma has the potential for widespread dissemination, such as metastasis to axillary lymph nodes, bone, lung, pleura, brain, and soft tissues.
  • Histopathological evaluation of the focal broad-based lesion of the gallbladder revealed poorly differentiated adenocarcinoma infiltration, without mucosal involvement.
  • The final pathological diagnosis was breast ductal papillary carcinoma metastases to the gallbladder.
  • Bone Tc-99 scintigraphy was normal.
  • Six months after the surgery positron emission tomography (PET) showed no evidence of metastatic disease.

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  • (PMID = 17139439.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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50. Nakamura H, Kuirhara Y, Matsushita K, Sakai A, Yamaguchi T, Nakajima Y: Extrarenal multiorgan metastases of collecting duct carcinoma of the kidney: a case series. J Med Case Rep; 2008;2:304

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • These lesions were biopsied, resulting in a histological diagnosis of metastatic adenocarcinoma.
  • Autopsy demonstrated the primary tumor to be collecting duct carcinoma, with metastases to lung, liver, spleen, bone marrow, right adrenal gland, and para-aortic lymph node.
  • Computed tomography done while the patient was alive detected lung, liver, and para-aortic lymph node metastases.
  • Autopsy revealed a primary tumor of collecting duct carcinoma with metastases to the liver, right adrenal gland, right upper ureter, bone marrow, para-aortic and mediastinal lymph nodes, and bone.
  • CONCLUSION: We present the radiological findings of lung, liver, lymph node, and bone metastases in two patients with collecting duct carcinoma.

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  • (PMID = 18798981.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2556681
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51. Pouessel D, Thezenas S, Culine S, Becht C, Senesse P, Ychou M: Hepatic metastases from carcinomas of unknown primary site. Gastroenterol Clin Biol; 2005 Dec;29(12):1224-32
MedlinePlus Health Information. consumer health - Liver Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AIM: Hepatic metastases are often present at diagnosis of carcinoma of unknown primary site (CUP).
  • METHODS: One hundred and eighteen patients were treated at the Cancer Center of Montpellier from 1993 to 2002 for CUP initially metastatic to the liver.
  • RESULTS: The most frequent histological types observed were adenocarcinoma, undifferentiated, neuroendocrine and squamous-cell carcinomas.
  • Other metastatic sites involved lymph nodes, lung and bone.

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  • (PMID = 16518276.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] EC 1.1.1.27 / L-Lactate Dehydrogenase
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52. Nogawa M, Yuasa T, Kimura S, Kuroda J, Sato K, Segawa H, Yokota A, Maekawa T: Monitoring luciferase-labeled cancer cell growth and metastasis in different in vivo models. Cancer Lett; 2005 Jan 20;217(2):243-53
MedlinePlus Health Information. consumer health - Diagnostic Imaging.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Here we show that the growth and metastases of HT1080 fibrosarcoma, A549 lung adenocarcinoma, and RENCA murine renal cancer cell lines in five different in vivo models can be successfully monitored by labeling the cells with luciferase prior to their implantation and then detecting their bioluminesence after injecting luciferin.
  • We also used this in vivo imaging system to successfully demonstrate that YM529, a third generation bisphosphonate, inhibited the growth of sarcoma metastases in bone.
  • We believe the models we have established in combination with the in vivo imaging system will be highly useful for future studies of metastasis and the testing of anti-metastatic therapies.
  • [MeSH-major] Cell Proliferation. Diagnostic Imaging / methods. Luciferases. Neoplasm Metastasis / diagnosis

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  • (PMID = 15617843.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Diphosphonates; 0 / Imidazoles; 127657-42-5 / YM 529; EC 1.13.12.- / Luciferases
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53. Maeda T, Kozakai N, Nishiyama T, Ishii T, Sugiura H, Nakamura K: [Gastric metastasis from renal cell carcinoma 20 months after radical nephrectomy: a case report]. Hinyokika Kiyo; 2009 Mar;55(3):137-40
MedlinePlus Health Information. consumer health - Stomach Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Metastatic lesions from renal cell carcinoma (RCC) commonly occur in the lung and bone, gastric metastasis has rarely been reported in the literature.
  • Endoscopic needle biopsy revealed poorly differentiated adenocarcinoma.
  • Partial gastrectomy was performed and histologic examination of the resected specimen confirmed diagnosis of clear cell renal carcinoma.

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  • (PMID = 19378824.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 11
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54. Geller SA: Challenges of utilizing immunostains to facilitate the diagnosis and management of metastatic adenocarcinoma. J Natl Med Assoc; 2009 May;101(5):478
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Challenges of utilizing immunostains to facilitate the diagnosis and management of metastatic adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Immunohistochemistry. Lung Neoplasms / pathology
  • [MeSH-minor] Adult. Bone Neoplasms / secondary. Brain Neoplasms / secondary. Female. Humans. Neoplasms, Unknown Primary / pathology

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  • [CommentOn] J Natl Med Assoc. 2008 Dec;100(12):1469-73 [19110917.001]
  • (PMID = 19476202.001).
  • [ISSN] 1943-4693
  • [Journal-full-title] Journal of the National Medical Association
  • [ISO-abbreviation] J Natl Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] United States
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