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1. Ramia JM, Villar J, Palomeque A, Muffak K, Mansilla A, Garrote D, Ferrón JA: [Duodenal adenocarcinoma]. Cir Esp; 2005 Apr;77(4):208-12
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  • [Title] [Duodenal adenocarcinoma].
  • [Transliterated title] Adenocarcinoma de duodeno.
  • INTRODUCTION: Duodenal adenocarcinoma is an infrequent neoplasm.
  • Consequently, there are no large series that would allow conclusions to be reached on its diagnosis and treatment.
  • PATIENTS AND METHOD: A retrospective study (1999-2003) of five patients diagnosed with duodenal adenocarcinoma in our service was performed.
  • All patients underwent gastrointestinal endoscopy with biopsy, which revealed adenocarcinoma.
  • In all patients, the preoperative diagnosis was correct.
  • A decision not to perform surgery was made in one patient with liver metastases.
  • CONCLUSION: Duodenal adenocarcinoma is an infrequent tumor that is associated with various diseases.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Duodenal Neoplasms / diagnosis. Duodenal Neoplasms / surgery

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  • (PMID = 16420919.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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2. Molina Granados JF, Escribano Fernández J, Vida Pérez L, Barrena Baena P: [Biliary obstruction due to adenocarcinoma of the ampulla of Vater ten years after orthotopic liver transplantation]. Radiologia; 2009 Nov-Dec;51(6):610-3
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  • [Title] [Biliary obstruction due to adenocarcinoma of the ampulla of Vater ten years after orthotopic liver transplantation].
  • [Transliterated title] Obstrucción biliar por adenocarcinoma de la papila de Vater en un paciente con trasplante hepático ortotópico.
  • The main causes of death in patients with liver transplants are derived from the graft itself.
  • Given the increased survival in this group of patients, the rate of de novo neoplasms in other locations is increasing.
  • We present the case of a 60-year-old man who underwent orthotopic liver transplantation 10 years earlier for terminal cirrhosis caused by hepatitis B.
  • Imaging studies showed dilation of the intra- and extra-hepatic bile ducts with no evidence of lithiasis, anastomotic stenosis, or other biliary complications that are common in patients with liver transplants.
  • The definitive diagnosis was reached by endoscopic retrograde cholangiopancreatography.
  • Adenocarcinoma of the ampulla of Vater should be considered among the causes of biliary obstruction in patients with orthotopic liver transplants.
  • [MeSH-major] Adenocarcinoma / complications. Ampulla of Vater. Cholestasis / etiology. Common Bile Duct Neoplasms / complications. Liver Transplantation / adverse effects

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  • (PMID = 19836032.001).
  • [ISSN] 0033-8338
  • [Journal-full-title] Radiología
  • [ISO-abbreviation] Radiologia
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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3. Lin CW, Hsu CC, Chang HC, Sun YC, Sun PL, Hsu CY, Perng DS: Hepatoid adenocarcinoma of the stomach with liver metastasis mimicking hepatocellular carcinoma: a case report. Cases J; 2009;2:6317

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  • [Title] Hepatoid adenocarcinoma of the stomach with liver metastasis mimicking hepatocellular carcinoma: a case report.
  • INTRODUCTION: Hepatoid adenocarcinoma is a special type of extrahepatic alpha-fetoprotein-producing adenocarcinoma, which has a morphologic similarity to hepatocellular carcinoma.
  • We report a patient with underlying hepatitis B virus infection and hepatoid adenocarcinoma with liver metastasis mimicking hepatocellular carcinoma.
  • CASE PRESENTATION: We present the case of a 56-year-old Chinese female with underlying hepatitis B virus infection, who was found to have multiple hepatic tumors by abdominal ultrasound and an elevated level of serum alpha-fetoprotein.
  • However, the tumor histology of the stomach and liver revealed glandular adenocarcinoma with hepatoid foci.
  • The final diagnosis is hepatoid adenocarcinoma of the stomach with liver metastasis.
  • CONCLUSION: Hepatoid adenocarcinoma is an aggressive tumor with liver metastasis being the first clinical manifestation of the neoplasm.
  • Hepatoid adenocarcinoma of the stomach with liver metastasis should be considered in older patients with elevated serum alpha-fetoprotein and multiple hepatic tumors with underlying chronic liver disease.
  • An upper gastrointestinal endoscopy should be performed to exclude the possibility of hepatoid adenocarcinoma originating from the stomach to avoid potential misdiagnosis and inappropriate therapy.

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  • (PMID = 19918575.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2769285
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4. Safaee A, Moghimi-Dehkordi B, Fatemi SR, Ghiasi S, Nemati-Malek F, Zali MR: Characteristics of colorectal mucinous adenocarcinoma in Iran. Asian Pac J Cancer Prev; 2010;11(5):1373-5
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  • [Title] Characteristics of colorectal mucinous adenocarcinoma in Iran.
  • AIMS AND BACKGROUND: Mucinous adenocarcinoma (MA) colorectal cancer accounts for 10 to 15% of colorectal carcinoma.
  • RESULTS: The median age of these patients at diagnosis was 50.07 years.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Colorectal Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Iran / epidemiology. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Staging. Prognosis. Survival Analysis. Survival Rate

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  • (PMID = 21198295.001).
  • [ISSN] 2476-762X
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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5. Wang L, Vuolo M, Suhrland MJ, Schlesinger K: HepPar1, MOC-31, pCEA, mCEA and CD10 for distinguishing hepatocellular carcinoma vs. metastatic adenocarcinoma in liver fine needle aspirates. Acta Cytol; 2006 May-Jun;50(3):257-62
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  • [Title] HepPar1, MOC-31, pCEA, mCEA and CD10 for distinguishing hepatocellular carcinoma vs. metastatic adenocarcinoma in liver fine needle aspirates.
  • OBJECTIVE: To investigate immunohistochemical staining of hepatocyte paraffin-1 (HepPar1), alpha-fetoprotein (AFP), polyclonal carcinoembryonic antigen (pCEA), monoclonal CEA (mCEA), MOC-31 and CD10 for differential diagnosis of hepatocellular carcinoma (HCC) from metastatic adenocarcinoma (MA) on fine needle aspiration biopsy (FNAB).
  • We suggest using HepPar1, pCEA, CD10, MOC-31 and mCEA as a panel for distinguishing HCC from MA in liver FNAB.
  • [MeSH-major] Adenocarcinoma / secondary. Antigens, Neoplasm / analysis. Biomarkers, Tumor / analysis. Carcinoma, Hepatocellular / pathology. Liver / pathology. Liver Neoplasms / pathology. Liver Neoplasms / secondary
  • [MeSH-minor] Biopsy, Fine-Needle. Carcinoembryonic Antigen / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Neprilysin / analysis. Retrospective Studies

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  • (PMID = 16780018.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen; EC 3.4.24.11 / Neprilysin
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6. Eickhoff A, Spiethoff A, Hartmann D, Jakobs R, Weickert U, Schilling D, Eickhoff JC, Bohrer MH, Riemann JF: [Space-occupying lesions in the liver: incidence of adenocarcinoma metastases of unknown primary site]. Dtsch Med Wochenschr; 2007 Feb 23;132(8):369-74
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  • [Title] [Space-occupying lesions in the liver: incidence of adenocarcinoma metastases of unknown primary site].
  • [Transliterated title] Unklare hepatische Raumforderungen: Häufigkeit von Adenokarzinom-Metastasen eines unbekannten Primärtumors.
  • BACKGROUND AND OBJECTIVE: The diagnostic approach to newly detected space-occupying lesions in the liver can be difficult and a histogenetic classification of the primary tumor is impossible in some cases.
  • The incidence of this diagnosis depends on the clinical and histochemical methods used.
  • It was the main aim of this study to analyze the true incidence of adenocarcinoma metastases of the liver with an unknown primary cancer after application of a standardized protocol of clinical and immunhistochemical diagnostic tests and a long-term follow-up.
  • PATIENTS AND METHODS: Between January 2000 and January 2003 127 consecutive patients underwent diagnostic ultrasound-guided biopsy of a space-occupying lesion in the liver.
  • Primary tumors of the liver were found in 21 cases and non-hepatocellular tumors (metastases) were documented in 106 patients, 82 of the latter (77%) had metastases of an adenocarcinoma.
  • The further diagnostic approach was based on histochemistry, immunhistochemistry and imaging techniques, making possible a full diagnosis of primary tumor in a further 59 (72%) cases.
  • Thus the incidence of an adenocarcinoma of the liver of unknown primary site was 23 of 127 cases (18%).
  • CONCLUSIONS: Although there is a wide variety of modern diagnostic methods today, the histogenetic classification of hepatic metastases is not always possible.
  • [MeSH-major] Adenocarcinoma / secondary. Liver Neoplasms / secondary. Neoplasms, Unknown Primary / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Algorithms. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Incidence. Karnofsky Performance Status. Liver / pathology. Liver / ultrasonography. Male. Middle Aged. Prognosis

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  • (PMID = 17299675.001).
  • [ISSN] 0012-0472
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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7. Dechaphunkul A, Kanngurn S, Dechsukhum C, Tanutit P, Khow-Ean U, Sunpaweravong P: The significance of galectin-3 immunohistochemistry, clinical characteristics and liver imaging in differentiating intrahepatic cholangiocarcinoma from adenocarcinoma liver metastasis. J Med Assoc Thai; 2010 May;93(5):523-8
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  • [Title] The significance of galectin-3 immunohistochemistry, clinical characteristics and liver imaging in differentiating intrahepatic cholangiocarcinoma from adenocarcinoma liver metastasis.
  • OBJECTIVE: To identify differences of Galectin-3 (Gal-3) immunostaining, clinical profiles, and images in patients with intrahepatic cholangiocarcinoma (IHC) and adenocarcinoma liver metastasis, and be able to recognize these parameters as diagnostic tools for differentiating these two diseases.
  • MATERIAL AND METHOD: Histological slides from patients with IHC and adenocarcinoma liver metastasis were reviewed Immunohistochemical staining for Gal-3, Cytokeratin-7 (CK-7), and Cytokeratin-20 (CK-20) was performed and the results categorized.
  • Moreover clinical characteristics and liver images of the patients were reviewed.
  • RESULTS: Eighty-two patients were evaluated, 31 IHC and 51 adenocarcinoma liver metastasis.
  • Finding showed that 86% of them were IHC whereas only 14% were in adenocarcinoma liver metastasis.
  • All patients with liver images showing a single lesion, located at central site, and having intrahepatic duct dilatation were IHC.
  • On the other hand, 77% of patients with liver imaging showing multiple liver masses, located at peripheral site and having no intrahepatic duct dilatation were adenocarcinoma liver metastasis while only 23% were in IHC.
  • CONCLUSION: Adding Gal-3 to CK-7 and CK-20 immunohistochemistry has benefits to differentiate IHC from adenocarcinoma liver metastasis.
  • Furthermore, liver imaging profiles also give benefits for differentiating between these two diseases.
  • [MeSH-major] Adenocarcinoma / diagnosis. Bile Duct Neoplasms / diagnosis. Cholangiocarcinoma / diagnosis. Galectin 3 / metabolism. Liver Neoplasms / diagnosis
  • [MeSH-minor] Adult. Bile Ducts, Intrahepatic / metabolism. Bile Ducts, Intrahepatic / pathology. Biomarkers, Tumor / metabolism. Female. Humans. Immunohistochemistry. Keratin-20 / metabolism. Keratin-7 / metabolism. Liver / radiography. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 20524437.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Galectin 3; 0 / Keratin-20; 0 / Keratin-7
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8. Germanos S, Gourgiotis S, Stavrothanasopoulou A, Alepas P, Zampitis N, Panteli A: Diagnostic and therapeutic approach to pancreatic adenocarcinoma. J Gastrointestin Liver Dis; 2006 Sep;15(3):257-63
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  • [Title] Diagnostic and therapeutic approach to pancreatic adenocarcinoma.
  • Pancreatic adenocarcinoma is the sixth leading cause of cancer-related death in Europe with survival rates remaining unchanged over the last three decades.
  • Early diagnosis and accurate staging are essential due to the difficulty of curing this tumor in its advanced form.
  • Endoscopic or laparoscopic ultrasonography and computed tomography are the preferred imaging and staging modalities for many patients with pancreatic adenocarcinoma.
  • This article reviews the causes, risk factors, and clinical features of pancreatic adeno-carcinoma and discusses the methods of optimal diagnosis, staging and treatment.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / therapy. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / therapy

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  • (PMID = 17013451.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Romania
  • [Number-of-references] 71
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9. Ghittoni G, Caturelli E, Viera FT: Intrabile duct metastasis from colonic adenocarcinoma without liver parenchyma involvement: contrast enhanced ultrasonography detection. Abdom Imaging; 2010 Jun;35(3):346-8

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  • [Title] Intrabile duct metastasis from colonic adenocarcinoma without liver parenchyma involvement: contrast enhanced ultrasonography detection.
  • It is well-known that biliary duct invasion with intraluminal growth is one of the developmental patterns of primary liver tumors, and macroscopic intrabiliary growth of liver metastases in colorectal cancer is found with high frequency.
  • We describe the first recorded case of a metastasis from colorectal cancer involving solely the common hepatic biliary duct, without invasion of contiguous liver parenchyma.
  • A correct diagnosis was obtained by means of contrast enhanced ultrasound and ultrasound-guided fine needle aspiration biopsy.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Colonic Neoplasms / pathology. Hepatic Duct, Common / pathology. Ultrasonography, Doppler, Color
  • [MeSH-minor] Aged. Biopsy, Fine-Needle. Cholangiography. Common Bile Duct / pathology. Common Bile Duct / ultrasonography. Humans. Image Enhancement. Lymphatic Metastasis. Male. Neoplasm Invasiveness

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  • (PMID = 19294464.001).
  • [ISSN] 1432-0509
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Eigenbrod T, Kullmann F, Klebl F: Resection of small bowel adenocarcinoma liver metastasis combined with neoadjuvant and adjuvant chemotherapy results in extended disease-free period--a case report. Int J Gastrointest Cancer; 2006;37(2-3):94-7
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  • [Title] Resection of small bowel adenocarcinoma liver metastasis combined with neoadjuvant and adjuvant chemotherapy results in extended disease-free period--a case report.
  • Small bowel adenocarcinoma (SBA) is a very rare tumor entity but occurs in up to 5% of patients suffering from familiar adenomatous polyposis (FAP).
  • Because of nonspecific symptoms, diagnosis is usually made with delay, which contributes to high rates of metastatic disease at the time of diagnosis.
  • In October 2001, a 51-year-old woman with attenuated FAP, that had total proctocolectomy in 1994 was diagnosed with a jejunal adenocarcinoma.
  • Because a computed tomography (CT) scan in April 2002 revealed multiple liver metastases, chemotherapy with nine cycles FOLFOX6 was initiated.
  • This solitary residual liver metastasis was resected in January 2004.
  • To date, more than 3 years after liver resection, the patient is still in complete remission and undergoes regular restaging investigations.
  • Resection of liver metastases from SBA combined with neoadjuvant and adjuvant chemotherapy can result in extended disease-free survival and should undergo further investigation.
  • [MeSH-major] Adenocarcinoma / therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Hepatectomy. Ileal Neoplasms / therapy. Jejunal Neoplasms / therapy. Liver Neoplasms / therapy. Neoadjuvant Therapy

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  • (PMID = 17827529.001).
  • [ISSN] 1537-3649
  • [Journal-full-title] International journal of gastrointestinal cancer
  • [ISO-abbreviation] Int J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 7673326042 / irinotecan; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin
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11. Schima W, Ba-Ssalamah A, Kölblinger C, Kulinna-Cosentini C, Puespoek A, Götzinger P: Pancreatic adenocarcinoma. Eur Radiol; 2007 Mar;17(3):638-49
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  • [Title] Pancreatic adenocarcinoma.
  • Adenocarcinoma is the most common malignant pancreatic tumor, affecting the head of the pancreas in 60-70% of cases.
  • By the time of diagnosis, at least 80% of tumors are unresectable.
  • Helical computed tomography (CT) is very effective in detecting and staging adenocarcinoma, with a sensitivity of up to 90% for detection and an accuracy of 80-90% for staging, but it has limitations in detecting small cancers.
  • Moreover, it is not very accurate for determining nonresectability because small liver metastases, peritoneal carcinomatosis, and subtle signs of vascular infiltration may be missed.
  • MDCT has been found to be at least equivalent to contrast-enhanced magnetic resonance imaging (MRI) for detecting adenocarcinoma.
  • It is the technique of choice for image-guided biopsy if a histologic diagnosis is required for further therapy.
  • [MeSH-major] Adenocarcinoma / diagnosis. Pancreatic Neoplasms / diagnosis. Tomography, X-Ray Computed
  • [MeSH-minor] Contrast Media. Endosonography. Humans. Magnetic Resonance Imaging. Neoplasm Staging

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  • (PMID = 17021700.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 65
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12. Katabi N: Neoplasia of gallbladder and biliary epithelium. Arch Pathol Lab Med; 2010 Nov;134(11):1621-7
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  • CONTEXT: Diagnosis of biliary neoplasia can be challenging but is essential for the appropriate clinical management of patients.
  • Therefore, it is important to recognize the morphologic features of the biliary neoplasms to report a correct diagnosis. OBJECTIVES:.
  • (1) To discuss the differential diagnosis of dysplasia in the gallbladder and differentiate dysplasia from reactive atypia and invasive carcinoma, (2) review the histologic features of adenoma and polypoid biliary lesions, (3) highlight the differential diagnosis of adenocarcinoma in liver biopsy, and (4) discuss the differential diagnosis of atypical biliary glandular lesions.
  • Careful examination of the histologic features of these lesions and familiarity with their morphology can help to achieve the correct diagnosis.
  • [MeSH-minor] Diagnosis, Differential. Humans. Metaplasia / pathology

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  • (PMID = 21043815.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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13. Barshack I, Meiri E, Rosenwald S, Lebanony D, Bronfeld M, Aviel-Ronen S, Rosenblatt K, Polak-Charcon S, Leizerman I, Ezagouri M, Zepeniuk M, Shabes N, Cohen L, Tabak S, Cohen D, Bentwich Z, Rosenfeld N: Differential diagnosis of hepatocellular carcinoma from metastatic tumors in the liver using microRNA expression. Int J Biochem Cell Biol; 2010 Aug;42(8):1355-62
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  • [Title] Differential diagnosis of hepatocellular carcinoma from metastatic tumors in the liver using microRNA expression.
  • Distinguishing hepatocellular carcinoma from metastatic tumors in the liver is of great practical importance, with significant therapeutic and prognostic implications.
  • This differential diagnosis can be difficult because metastatic cancers in the liver, especially adenocarcinomas, may mimic the morphology and immunoexpression of hepatocellular carcinoma.
  • Biomarkers that are specifically expressed in either hepatocellular carcinoma or metastatic adenocarcinoma can therefore be useful diagnostic tools.
  • Hsa-miR-141 and hsa-miR-200c, microRNAs that promote epithelial phenotypes, had significantly higher levels in non-hepatic epithelial tumors.
  • Combinations of these microRNAs accurately identified primary hepatocellular carcinoma from metastatic adenocarcinoma in the liver.
  • Thus, the tissue-specific expression patterns of microRNAs make them useful biomarkers for the diagnosis of liver malignancies.
  • [MeSH-major] Carcinoma, Hepatocellular / diagnosis. Carcinoma, Hepatocellular / genetics. Gene Expression Regulation, Neoplastic. Liver / metabolism. Liver Neoplasms / diagnosis. Liver Neoplasms / genetics. MicroRNAs / genetics
  • [MeSH-minor] Diagnosis, Differential. Humans. Neoplasm Metastasis. ROC Curve. Reverse Transcriptase Polymerase Chain Reaction

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  • [Copyright] Copyright 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 20619223.001).
  • [ISSN] 1878-5875
  • [Journal-full-title] The international journal of biochemistry & cell biology
  • [ISO-abbreviation] Int. J. Biochem. Cell Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / MicroRNAs
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14. Ambro CM, Humphreys TR, Lee JB: Epidermotropically metastatic pancreatic adenocarcinoma. Am J Dermatopathol; 2006 Feb;28(1):60-2
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  • [Title] Epidermotropically metastatic pancreatic adenocarcinoma.
  • We describe an epidermotropically metastatic pancreatic mucinous ductal adenocarcinoma on the scalp.
  • The patient's history of pancreatic mucinous ductal adenocarcinoma and immunohistochemical staining pattern of carbohydrate antigen 19-9 (CA 19-9) confirmed the diagnosis.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Carcinoma, Pancreatic Ductal / secondary. Pancreatic Neoplasms / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Biomarkers, Tumor / analysis. CA-19-9 Antigen / analysis. Humans. Liver Neoplasms / secondary. Male. Middle Aged

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  • (PMID = 16456328.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen
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15. Fraguela Mariña JA, Fernández Blanco C, Alonso Fernández L, Taboada Filgueira L, Robles Veiga O, Gómez Freijoso C: [Liver metastases from colonic adenocarcinoma simulating cholangiocarcinoma]. Gastroenterol Hepatol; 2007 Oct;30(8):454-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Liver metastases from colonic adenocarcinoma simulating cholangiocarcinoma].
  • [Transliterated title] Metástasis hepática de cáncer de recto simulando un colangiocarcinoma.
  • Macroscopic intrabiliary growth of liver metastases from colonic adenocarcinoma mimicking cholangiocarcinoma, a pattern of intrahepatic spread easily confused with primary neoplasia of the biliary tract, is extremely infrequent.
  • Resection of liver metastases has a better prognosis than that of primary neoplasia of the biliary tract.
  • We report a case of metastasis from adenocarcinoma of the colon that presented as a Klatskin tumor.
  • The definitive diagnosis was established by immunostaining.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Bile Duct Neoplasms / diagnosis. Cholangiocarcinoma / diagnosis. Colonic Neoplasms / pathology. Klatskin Tumor / diagnosis. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 17949611.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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16. Tanaka H, Sato H, Konishi Y, Fujimoto T, Takahashi O, Tanaka T: Endometrial adenocarcinoma after liver transplantation. J Obstet Gynaecol Res; 2005 Jun;31(3):224-6
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  • [Title] Endometrial adenocarcinoma after liver transplantation.
  • In June 1999, a 50-year-old Japanese woman underwent a liver transplant and was started on tacrolimus hydrate.
  • In December 2001, the patient was found to suffer from endometrial adenocarcinoma and total abdominal hysterectomy with adnexa was carried out.
  • No significant changes in liver function were observed.
  • The present case is the first report of endometrial adenocarcinoma in a patient after liver transplantation.
  • [MeSH-major] Adenocarcinoma / diagnosis. Endometrial Neoplasms / diagnosis. Liver Transplantation
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 15916658.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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17. Hornick JL, Lauwers GY, Odze RD: Immunohistochemistry can help distinguish metastatic pancreatic adenocarcinomas from bile duct adenomas and hamartomas of the liver. Am J Surg Pathol; 2005 Mar;29(3):381-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemistry can help distinguish metastatic pancreatic adenocarcinomas from bile duct adenomas and hamartomas of the liver.
  • Not uncommonly, bile duct adenomas (BDAs) and hamartomas (BDHs) of the liver may be difficult to distinguish from metastatic well-differentiated ductal adenocarcinoma of the pancreas.
  • The primary purpose of this study was to determine if a panel of immunohistochemical stains can help distinguish BDA or BDH from metastatic pancreatic adenocarcinoma in the liver.
  • Routinely processed tissue sections from 25 BDA, 10 BDH, 25 metastatic pancreatic adenocarcinomas to the liver and 6 cases each of metastatic colorectal, breast, and lung adenocarcinomas were immunohistochemically stained for CK7, CK8/CK18, CK19, CK20, p53, p63, TAG-72, monoclonal CEA (mCEA), polyclonal CEA (pCEA), HER-2/neu, AMACR (alpha-methylacyl-CoA racemase), Dpc4 (Smad4), and mesothelin.
  • The slides were evaluated in a blinded fashion, and the results were compared between the benign and malignant lesions.
  • Of these antibodies, p53, TAG-72, mCEA, loss of Dpc4, and mesothelin had the highest specificity for pancreatic adenocarcinoma, with mCEA having the highest sensitivity (92%).
  • For nonpancreatic adenocarcinomas, mCEA showed a reasonably high sensitivity and 100% specificity in the differential diagnosis versus BDA.
  • Immunohistochemical expression of p53, TAG-72, mCEA, mesothelin, and loss of Dpc4 can help distinguish metastatic pancreatic adenocarcinoma in the liver from BDA or BDH.
  • Although p63 and AMACR are also specific for pancreatic adenocarcinoma, their low sensitivity limits their use in clinical practice.
  • [MeSH-major] Adenocarcinoma / secondary. Adenoma / pathology. Bile Duct Neoplasms / pathology. Hamartoma / pathology. Liver Diseases / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Immunoenzyme Techniques


18. Shinji S, Naito Z, Ishiwata T, Tanaka N, Furukawa K, Suzuki H, Seya T, Kan H, Tsuruta H, Matsumoto S, Matsuda A, Teranishi N, Ohaki Y, Tajiri T: Neuroendocrine cell differentiation of poorly differentiated colorectal adenocarcinoma correlates with liver metastasis. Int J Oncol; 2006 Aug;29(2):357-64
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  • [Title] Neuroendocrine cell differentiation of poorly differentiated colorectal adenocarcinoma correlates with liver metastasis.
  • Poorly differentiated (PD) adenocarcinoma often retains the capacity for neuroendocrine (NE) cell differ-entiation; however, it is difficult to distinguish the NE cell differentiation by routine hematoxylin and eosin staining.
  • It is important to detect the presence of NE cell differentiation in advanced colorectal carcinomas because these carcinomas have been shown to produce distant metastasis at the time of diagnosis and to have a particularly poor prognosis.
  • In this study, the characteristics of PD adenocarcinoma with NE cell differentiation and its biological metastatic mechanisms were investigated.
  • Forty-eight of 2204 colorectal cancer patients, diagnosed as having PD adenocarcinoma (2.2%) were enrolled in this study.
  • The clinicopathological factors for PD adenocarcinoma with NE cell differentiation were compared with those for PD adenocarcinoma without NE cell differentiation.
  • Microvessel density (MVD) was assessed using immunostained slides with anti-CD34 antibody and vascular endothelial growth factor (VEGF) expression in PD adenocarcinoma with NE cell differentiation was confirmed by in situ hybridization.
  • By immunohistochemical staining for chromogranin A and synaptophysin, NE cell differentiation was detected in eight of 48 patients (16.7%) with PD adenocarcinoma.
  • The frequency of liver metastasis at the time of diagnosis was significantly higher in patients having PD adenocarcinoma with NE cell differentiation (p=0.03).
  • Moreover, MVD and VEGF expression level tended to be higher in patients having PD adenocarcinoma with NE cell differentiation (p=0.13 and 0.068, respectively).
  • NE cell differentiation in PD adenocarcinoma may produce liver metastasis through microvessel formation in the tumor induced by VEGF.
  • In PD colorectal adenocarcinoma, immunohistochemical analysis of NE markers is important for establishing the presence of NE cell differentiation and further study is necessary to evaluate the effectiveness of anti-angiogenic drugs to PD adenocarcinoma with NE cell differentiation.
  • [MeSH-major] Adenocarcinoma / metabolism. Antibodies, Monoclonal / chemistry. Carcinoma, Neuroendocrine / pathology. Colorectal Neoplasms / metabolism. Liver Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antibodies, Monoclonal, Murine-Derived. Antigens, CD34 / biosynthesis. Cell Differentiation. Female. Humans. Male. Middle Aged. Neoplasm Metastasis

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  • (PMID = 16820877.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, CD34; 0 / monoclonal antibody D2-40
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19. Vrettou E, Hytiroglou P, Sikas N, Soultoyannis I, Goodman ZD: Hepatic adenocarcinoma expressing inhibin in a young patient on oral contraceptives. Virchows Arch; 2005 May;446(5):560-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hepatic adenocarcinoma expressing inhibin in a young patient on oral contraceptives.
  • A case of primary hepatic carcinoma is reported, which occurred in a 24-year-old woman with a 10-year history of oral contraceptive use, and demonstrated unique morphologic and immunohistochemical features.
  • The tumor was located in the left hepatic lobe, measured 14 cm at its widest, and showed histologic heterogeneity.
  • Interestingly, they were positive for inhibin, a protein that is known to be expressed in sex cord-stromal tumors of the ovary, trophoblastic neoplasms and adrenal cortical tumors, but not in hepatic tumors.
  • [MeSH-major] Adenocarcinoma / diagnosis. Contraceptives, Oral, Combined / administration & dosage. Inhibins / analysis. Liver Neoplasms / diagnosis

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  • (PMID = 15815932.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen; 0 / Contraceptives, Oral, Combined; 0 / KRT7 protein, human; 0 / Keratin-7; 57285-09-3 / Inhibins; 68238-35-7 / Keratins
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20. Wang C, Zhou XG: [Role of CDX2 immunostaining in diagnosis of gastrointestinal adenocarcinoma]. Zhonghua Bing Li Xue Za Zhi; 2006 Apr;35(4):228-31

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Role of CDX2 immunostaining in diagnosis of gastrointestinal adenocarcinoma].
  • OBJECTIVE: To study the expression of CDX2 in normal and tumor tissues, and to evaluate the value of CDX2 immunostaining in the diagnosis of gastrointestinal adenocarcinoma.
  • RESULTS: CDX2 was strongly expressed in surface epithelium of 13 samples of normal intestine and in ductal epithelium of 8 samples of normal pancreas, as well as in 47 samples (92.2%) of colonic adenocarcinoma and 58 samples (66.9%) of gastric adenocarcinoma.
  • The positivity rates were as follows: ovarian mucinous adenocarcinoma 15.6% (10/64), pancreatic cancer 33.3% (3/9), thyroid cancer 27.3% (3/11) and extrahepatic biliary cancer 25% (4/16).
  • On the other hand, primary tumors of breast, prostate, kidney, adrenal and liver were negative for CDX2.
  • CONCLUSIONS: CDX2 is expressed mainly in normal epithelium of intestinal tract and small pancreatic ducts, as well as in primary adenocarcinoma of gastrointestinal tract.
  • CDX2 may thus play an important role in distinguishing primary non-intestinal adenocarcinoma from metastatic adenocarcinoma of gastric or colorectal primary.
  • [MeSH-major] Adenocarcinoma / diagnosis. Gastrointestinal Neoplasms / diagnosis. Homeodomain Proteins / metabolism
  • [MeSH-minor] Colonic Neoplasms / diagnosis. Colonic Neoplasms / metabolism. Female. Gastrointestinal Tract / chemistry. Gastrointestinal Tract / pathology. Humans. Immunohistochemistry. Male. Stomach Neoplasms / diagnosis. Stomach Neoplasms / metabolism. Tissue Array Analysis

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  • (PMID = 16776981.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / CDX2 protein, human; 0 / Homeodomain Proteins
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21. Tazi N, Le Thi Huong D, Bodaghi B, Rixe O, Lehoang P, Piette JC: [Choroidal metastasis revealing pulmonary adenocarcinoma]. Rev Med Interne; 2006 Sep;27(9):699-701
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  • [Title] [Choroidal metastasis revealing pulmonary adenocarcinoma].
  • He presented with visual decrease and metamorphopsia that lead to the diagnosis of a metastatic adenocarcinoma of the lung (bone, liver, choroid, nodles).

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  • (PMID = 16872723.001).
  • [ISSN] 0248-8663
  • [Journal-full-title] La Revue de medecine interne
  • [ISO-abbreviation] Rev Med Interne
  • [Language] FRE
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Phytogenic; 0 / Taxoids; 15H5577CQD / docetaxel; Q20Q21Q62J / Cisplatin
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22. Miller FH, Rini NJ, Keppke AL: MRI of adenocarcinoma of the pancreas. AJR Am J Roentgenol; 2006 Oct;187(4):W365-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MRI of adenocarcinoma of the pancreas.
  • OBJECTIVE: CT is the established imaging technique for evaluation of pancreatic adenocarcinoma.
  • The objective of this study is to illustrate the strengths of MRI for evaluating pancreatic adenocarcinoma.
  • MRI compared with CT may be more sensitive in the detection of distant disease, better for defining appropriate surgical candidates, and better for characterizing small liver metastases and peritoneal and omental metastases.
  • [MeSH-major] Adenocarcinoma / diagnosis. Magnetic Resonance Imaging. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Adult. Carcinoma, Pancreatic Ductal / diagnosis. Carcinoma, Pancreatic Ductal / radiography. Diagnosis, Differential. Humans. Liver Neoplasms / radiography. Liver Neoplasms / secondary. Lymphatic Metastasis. Male. Middle Aged. Pancreatitis / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 16985107.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Kato K, Suzuka K, Osaki T, Itami M, Tanaka N: Primary hepatoid adenocarcinoma of the uterine cervix. Int J Gynecol Cancer; 2007 Sep-Oct;17(5):1150-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary hepatoid adenocarcinoma of the uterine cervix.
  • Hepatoid adenocarcinoma is characterized histologically by neoplastic epithelial cells that resemble hepatocellular carcinoma (HCC) and produce alpha-fetoprotein (AFP).
  • We describe a case of hepatoid adenocarcinoma of the uterus that, unlike any other previously reported case, was strictly confined to the cervix.
  • A cervical biopsy demonstrated poorly differentiated adenocarcinoma, and hysterectomy and bilateral salpingo-oophorectomy were subsequently performed.
  • Histologically, the lesion consisted of solid sheets of hepatoid cells accompanied with areas of endometroid adenocarcinoma.
  • The tumor cells showed strong and diffuse cytoplasmic immunoreactivity with AFP in both medullary and adenocarcinoma components.
  • To our knowledge, this is the first report of primary hepatoid adenocarcinoma of the uterine cervix.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Hepatocellular / pathology. Liver Neoplasms / pathology. Uterine Cervical Neoplasms / diagnosis

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  • (PMID = 17367323.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
  • [Number-of-references] 15
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24. Hong K, McBride JD, Georgiades CS, Reyes DK, Herman JM, Kamel IR, Geschwind JF: Salvage therapy for liver-dominant colorectal metastatic adenocarcinoma: comparison between transcatheter arterial chemoembolization versus yttrium-90 radioembolization. J Vasc Interv Radiol; 2009 Mar;20(3):360-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Salvage therapy for liver-dominant colorectal metastatic adenocarcinoma: comparison between transcatheter arterial chemoembolization versus yttrium-90 radioembolization.
  • PURPOSE: To compare transarterial chemoembolization (CE) versus yttrium-90 ((90)Y) radioembolization (RE) for liver-dominant metastatic colorectal adenocarcinoma as salvage therapy.
  • MATERIALS AND METHODS: Of 36 patients, 21 underwent CE (37 procedures; 11 men; mean age, 67 years; 16 with Child-Pugh class A disease) and 15 underwent (90)Y RE (19 procedures; 11 men; mean age, 64 years; 13 with Child-Pugh class A disease) for liver-dominant colorectal adenocarcinoma.
  • Mean times from diagnosis of liver metastasis to CE or RE were 17.6 months and 22.6 months, respectively.
  • CONCLUSIONS: Patients with unresectable liver colorectal metastases that progress despite systemic chemotherapy can undergo palliative treatment with CE or RE with similar survival benefit.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / therapy. Chemoembolization, Therapeutic / methods. Colorectal Neoplasms / therapy. Liver Neoplasms / secondary. Liver Neoplasms / therapy. Yttrium Radioisotopes / therapeutic use

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  • (PMID = 19167245.001).
  • [ISSN] 1535-7732
  • [Journal-full-title] Journal of vascular and interventional radiology : JVIR
  • [ISO-abbreviation] J Vasc Interv Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Radiopharmaceuticals; 0 / Yttrium Radioisotopes
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25. Jeong EH, Kim DH, Ma SH, Chung EJ, Bae SS, Park AY, Chu HJ: [A case of liver metastasis of gastric hepatoid adenocarcinoma]. Korean J Hepatol; 2009 Jun;15(2):201-8
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  • [Title] [A case of liver metastasis of gastric hepatoid adenocarcinoma].
  • We report herein a case of hepatoid adenocarcinoma of the stomach with liver metastasis.
  • Gastric carcinoma generally presents as adenocarcinoma and rarely shows a hepatoid pattern, which can produce alpha-fetoprotein (AFP).
  • The stomach is one of the common sites at which hepatoid adenocarcinoma has been detected.
  • Abdominal computed tomography revealed multiple liver masses.
  • Biopsy samples of the gastric lesion and liver masses finally confirmed her case as hepatoid adenocarcinoma in the stomach with liver metastasis.
  • The AFP-producing gastric carcinoma needs special attention because it often presents with early liver metastasis and has a poor prognosis.
  • [MeSH-major] Adenocarcinoma / diagnosis. Liver Neoplasms / diagnosis. Stomach Neoplasms / diagnosis

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  • (PMID = 19581772.001).
  • [ISSN] 1738-222X
  • [Journal-full-title] The Korean journal of hepatology
  • [ISO-abbreviation] Korean J Hepatol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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26. Murad JC, Ribeiro U Jr, Safatle-Ribeiro AV, Parra E, Rawet V, Corbett CE, Ferreira VA, Pugliese V, Saad WA, Habr-Gama A, Gama-Rodrigues J: Evaluation of molecular markers in hepatic metastasis of colorectal adenocarcinoma. Hepatogastroenterology; 2007 Jun;54(76):1029-33
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  • [Title] Evaluation of molecular markers in hepatic metastasis of colorectal adenocarcinoma.
  • BACKGROUND/AIMS: There were 49 patients studied, coming from The Liver Unit at the "Hospital das Clinicas da Faculdade de Medicina da USP (N=41) and from "Prof. Dr.
  • Angelita Habr-Gama and Joaquim Gama-Rodrigues Surgery Institute", SP (N=8); all of which had hepatic metastasis of colorectal adenocarcinoma, with no evidence of concurrent metastasis in any other organs and were submitted to surgical treatment, during the period of 1992 to 2002, with the aim of analyzing the immunoexpression of the p53, ki-67, p16 and molecular markers in order to relate the disease-free period with the prognosis.
  • METHODOLOGY: The patient's clinical data were analyzed retrospectively for verification of information such as age, gender, size of the hepatic metastasis and/or the largest lesion, number of satellite nodules resected and compromised, margin of resection free from neoplasia.
  • The proliferation marker ki-67 was not associated with the reduction of the disease-free interval and survival; the immunoexpression of the proliferation marker p16 was not associated with the reduction of disease-free period and survival, however, it was associated with hepatic metastasis synchronism.
  • In patients who received postoperative systemic chemotherapy with 5-FU and leucovorin, the immunoexpression on the hepatic metastasis was not associated with a longer disease-free interval.
  • CONCLUSIONS: Molcular markers may be useful to evaluate hepatic metastasis of colorectal Adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Biomarkers, Tumor / analysis. Colorectal Neoplasms / pathology. Liver Neoplasms / diagnosis

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  • (PMID = 17629032.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53; EC 2.1.1.45 / Thymidylate Synthase
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27. Maksimović S: [Survival rates of patients with mucinous adenocarcinoma of the colorectum]. Med Arh; 2007;61(1):26-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Survival rates of patients with mucinous adenocarcinoma of the colorectum].
  • PURPOSE: Mucinous adenocarcinoma is one of the histological subtypes of colorectal cancer.
  • Frequently are more advanced at diagnosis and have a poorer prognosis than nonmucinous colorectal adenocarcinomas.
  • To determine whether the mucinous adenocarcinoma itself was independent prognostic factor in the curative resected patients, a multivariate analysis was performed.
  • RESULTS: The mucinous adenocarcinoma patients compared to patients with nonmucinous adenocarcinoma patients were found to be younger (p= 0,001), have more lymph node metastases (46,15% vs. 38,31%, p=0,0053), more peritoneal dissemination (20,51% vs. 5,1%, p <0,0001), greater frequency of advanced stage disease (p= 0,0006), lower rate of curative resection (76,3% vs. 84,9%, p=0,0045), and lower overall 5-year survival rates (39% vs. 60,3%, p=0,0002.
  • Although the weight of the published literature suggests that mucinous adenocarcinoma is associated with poorer outcome, contradictory reports suggest that the clinical relevance of this histological type in this patient population remains unclear The lack of consensus may be attributable to the limited detection power inherent in studies that test small subsets of patients and the diversity inherent in the inclusion of patients with all Dukes' stages in the analysis.
  • Indeed, these series studied prognosis from initial diagnosis, generally in patients treated with surgery alone, and did not specifically address outcomes in patients treated with chemotherapy.
  • Mucinous tumors were associated with a higher proportion of patients with nodal metastases and peritoneal metastases, while the most common site of metastases for patients with non-mucinous histology was the liver.
  • [MeSH-major] Adenocarcinoma, Mucinous / mortality. Colorectal Neoplasms / mortality

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  • (PMID = 17582971.001).
  • [Journal-full-title] Medicinski arhiv
  • [ISO-abbreviation] Med Arh
  • [Language] bos
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Bosnia and Herzegovina
  • [Number-of-references] 25
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28. Yang CK, Zhao WJ, Dai QB, Zhang HH, Zheng W: [Clinical characteristics, diagnosis and treatment of hepatoid adenocarcinoma of the stomach]. Zhonghua Wei Chang Wai Ke Za Zhi; 2007 May;10(3):245-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical characteristics, diagnosis and treatment of hepatoid adenocarcinoma of the stomach].
  • OBJECTIVE: To investigate the clinical characteristics,diagnosis and treatment of hepatoid adenocarcinoma of the stomach.
  • The metastasis rates of liver and lymph node in hepatoid adenocarcinoma of stomach were higher than those in non-hepatoid adenocarcinoma of stomach.
  • The treatment of hepatoid adenocarcinoma of stomach depended mainly on radical resection, and adjuvant chemotherapy was needed.The prognosis of hepatoid adenocarcinoma of stomach was poor.
  • CONCLUSION: Hepatoid adenocarcinoma of the stomach has its own special tumor biological behavior and poor prognosis.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / therapy. Stomach Neoplasms / diagnosis. Stomach Neoplasms / therapy

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  • (PMID = 17520383.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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29. Stilwell G, Peleteiro MC: Uterine adenocarcinoma with pulmonary, liver and mesentery metastasis in a holstein cow. Vet Med Int; 2010;2010:727856

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Uterine adenocarcinoma with pulmonary, liver and mesentery metastasis in a holstein cow.
  • The clinical and pathology features of a cow with uterine adenocarcinoma and multiple metastasis are described.
  • Necropsy and histopathology exam revealed a uterine adenocarcinoma with multiple pulmonary, liver and mesentery metastasis.
  • Uterine adenocarcinoma with metastasis should be included in the differential diagnosis of cows showing weight loss and mild respiratory distress and palpation of numerous firm nodules in the mesentery should be suggestive of neoplasias' metastasis.

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  • [Cites] J Am Vet Med Assoc. 1970 Dec 1;157(11):1577-84 [4098649.001]
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  • (PMID = 20445789.001).
  • [ISSN] 2042-0048
  • [Journal-full-title] Veterinary medicine international
  • [ISO-abbreviation] Vet Med Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2860195
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30. Ahn SE, Lee HL, Lee OY, Yoon BC, Choi HS, Hahm JS, Park SW, Park HS: [Colonic metastasis from primary lung adenocarcinoma]. Korean J Gastroenterol; 2009 Feb;53(2):121-5
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  • [Title] [Colonic metastasis from primary lung adenocarcinoma].
  • The preferential sites of extrapulmonary spread include lymph nodes, liver, brain, adrenal glands, and bones.
  • Herein, we report a case of metastatic colon cancer from primary lung adenocarcinoma, presenting multiple cecal polypoid masses.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Colonic Neoplasms / secondary. Lung Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male. Radionuclide Imaging. Tomography, X-Ray Computed

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  • (PMID = 19237839.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
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31. Hori T, Wagata T, Takemoto K, Shigeta T, Takuwa H, Hata K, Uemoto S, Yokoo N: Spontaneous necrosis of solid gallbladder adenocarcinoma accompanied with pancreaticobiliary maljunction. World J Gastroenterol; 2008 Oct 14;14(38):5933-7
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  • [Title] Spontaneous necrosis of solid gallbladder adenocarcinoma accompanied with pancreaticobiliary maljunction.
  • We were agonized in making the qualitative diagnosis of mass-like lesions of the fundus, such as a benign tumor, cancer, or debris.
  • Although this necrotic nodule included non-viable adenocarcinoma cells, viable cancer cell nests were located in the muscularis propria and subcutaneous layer.
  • Histopathological examination confirmed a solid adenocarcinoma.
  • We therefore undertook radical surgery, including wedge resection of the liver, radical dissection of regional lymph nodes, and resection of the extrahepatic bile duct.
  • We present the first case of spontaneous necrosis of solid gallbladder adenocarcinoma, with a review of previous studies.
  • [MeSH-major] Adenocarcinoma / pathology. Biliary Tract / abnormalities. Gallbladder Neoplasms / pathology. Incidental Findings. Pancreas / abnormalities
  • [MeSH-minor] Aged. Cholangiography. Cholecystectomy, Laparoscopic. Cholecystitis, Acute / surgery. Fatal Outcome. Gallstones / surgery. Humans. Lymph Node Excision. Magnetic Resonance Imaging. Male. Necrosis. Neoplasm Staging. Tomography, X-Ray Computed. Treatment Outcome. Ultrasonography, Doppler

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  • (PMID = 18855999.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 25
  • [Other-IDs] NLM/ PMC2751910
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32. Yamano T, Morii E, Arai I, Takada T, Kubota K, Sato M, Inoue T, Okada Y, Hara T, Aozasa K: Diagnosis of primary versus metastatic ovarian adenocarcinoma using p53 gene mutation analysis. Int J Clin Oncol; 2010 Dec;15(6):621-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnosis of primary versus metastatic ovarian adenocarcinoma using p53 gene mutation analysis.
  • We assessed the usefulness of p53 gene mutation analysis for the differential diagnosis of ovarian adenocarcinoma.
  • A 66-year-old woman suffered multiple organ metastases, including the liver, para-aortic lymph node, and right ovary, following an operation for advanced sigmoid colon cancer.
  • She underwent ovarian resection after effective chemotherapy against the liver and para-aortic lymph node cancer.
  • Therefore, we applied p53 gene mutation analysis for the differential diagnosis of primary versus metastatic ovarian cancer from sigmoid colon cancer.
  • Although p53 gene mutation analysis has been applied in some cases, this modality is very useful for the differential diagnosis of primary and metastatic cancer.
  • [MeSH-major] Liver Neoplasms / genetics. Liver Neoplasms / secondary. Mutation / genetics. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / genetics. Tumor Suppressor Protein p53 / genetics
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / genetics. Adenocarcinoma / secondary. Aged. Colonic Neoplasms / diagnosis. Colonic Neoplasms / genetics. Diagnosis, Differential. Female. Humans. Lymphatic Metastasis

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  • (PMID = 20514505.001).
  • [ISSN] 1437-7772
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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33. Simsir A, Chhieng D, Wei XJ, Yee H, Waisman J, Cangiarella J: Utility of CD10 and RCCma in the diagnosis of metastatic conventional renal-cell adenocarcinoma by fine-needle aspiration biopsy. Diagn Cytopathol; 2005 Jul;33(1):3-7
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  • [Title] Utility of CD10 and RCCma in the diagnosis of metastatic conventional renal-cell adenocarcinoma by fine-needle aspiration biopsy.
  • The cytologic diagnosis of primary conventional renal-cell adenocarcinoma (cRCC) is usually straightforward; however, metastatic cRCC must be distinguished from a variety of neoplasms with clear-cell features.
  • CD10, a cell membrane-associated neutral endopeptidase, and renal-cell carcinoma marker (RCCma), an antibody against human proximal tubular brush border antigen, have recently been shown to be useful in the diagnosis of cRCC.
  • We compared CD10 and RCCma in cell block material from fine-needle aspiration biopsies (FNABs) to assess their utility in the diagnosis of metastatic cRCC, in cytologic specimens.
  • The immunoreactivity results were compared with those of a variety of neoplasms originating from other sites such as the liver, lungs, breast, and the gastrointestinal tract.
  • We conclude that CD10 has limited value in confirming the diagnosis of cRCC because of its low specificity.
  • [MeSH-minor] Aged. Aged, 80 and over. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Kidney / chemistry. Kidney / pathology. Male. Middle Aged. Neoplasm Metastasis. Sensitivity and Specificity

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  • [Copyright] 2005 Wiley-Liss, Inc
  • (PMID = 15945081.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.4.24.11 / Neprilysin
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34. Voutsadakis IA, Doumas S, Tsapakidis K, Papagianni M, Papandreou CN: Bone and brain metastases from ampullary adenocarcinoma. World J Gastroenterol; 2009 Jun 7;15(21):2665-8
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  • [Title] Bone and brain metastases from ampullary adenocarcinoma.
  • Ampullary carcinoma is the second most common cancer of the peri-ampullary area after pancreatic carcinoma and metastasizes mostly intra-abdominally and to the liver.
  • In this report we describe the case of a patient with resected adenocarcinoma of the ampulla of Vater who developed skeletal metastases in the lower extremity and brain metastases.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater / pathology. Bone Neoplasms / secondary. Brain Neoplasms / secondary. Common Bile Duct Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Fatal Outcome. Female. Humans. Middle Aged. Neoplasm Metastasis

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  • (PMID = 19496199.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2691500
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35. Chu PG, Schwarz RE, Lau SK, Yen Y, Weiss LM: Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2. Am J Surg Pathol; 2005 Mar;29(3):359-67
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2.
  • Pancreatobiliary and ampulla of Vater adenocarcinomas frequently metastasize to regional lymph nodes, liver, or lung and are difficult to diagnose because they lack specific immunohistochemical markers.
  • We concluded that CK17 is a useful marker in separating pancreatobiliary adenocarcinomas from extra-pancreatobiliary nonmucinous adenocarcinomas, including adenocarcinomas from the colon, breast, gynecologic organs, stomach, lung, prostate, thyroid, kidney, and adrenal gland, and malignant mesothelioma.
  • MUC2+/CDX2+ can be used as positive markers for the intestinal-type adenocarcinoma of duodenal papillary origin with a positive predictive value of 82%.
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Biomarkers, Tumor / metabolism. Female. Homeodomain Proteins / metabolism. Humans. Immunohistochemistry. Keratins / metabolism. Male. Mucins / metabolism. Neoplasm Proteins / metabolism

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  • (PMID = 15725805.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / Mucins; 0 / Neoplasm Proteins; 68238-35-7 / Keratins
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36. Jahan M, Xiao P, Go A, Cheema M, Hameed A: Intraductal and invasive adenocarcinoma of duct of Luschka, mimicking chronic cholecystitis and cholelithiasis. World J Surg Oncol; 2009;7:4
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  • [Title] Intraductal and invasive adenocarcinoma of duct of Luschka, mimicking chronic cholecystitis and cholelithiasis.
  • BACKGROUND: Intraductal and invasive adenocarcinoma of duct of Luschka is rare.
  • Ultrasound examination revealed thickening of gallbladder wall with abnormal septation around liver bed.
  • Patient underwent laparoscopic cholecystectomy and resection of the adjacent liver bed.
  • Histologic examination confirmed an intraductal and invasive adenocarcinoma arising from Luschka ducts.
  • CONCLUSION: Adenocarcinoma of ducts of Luschka should be considered among differential diagnoses for the patients with typical clinical presentations of chronic cholecystitis and cholelithiasis.
  • [MeSH-major] Adenocarcinoma / diagnosis. Bile Duct Neoplasms / diagnosis. Cholecystectomy, Laparoscopic. Cholecystitis / diagnosis. Cholelithiasis / diagnosis
  • [MeSH-minor] Adult. Chronic Disease. Diagnosis, Differential. Female. Humans. Liver Neoplasms / secondary. Liver Neoplasms / surgery. Neoplasm Invasiveness

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  • (PMID = 19128463.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2631453
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37. Klopfleisch R, van der Grinten E, Gruber AD: Metastatic uterine adenocarcinoma and hepatic lipomatosis in a llama (Lama glama). J Vet Diagn Invest; 2009 Mar;21(2):280-2
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  • [Title] Metastatic uterine adenocarcinoma and hepatic lipomatosis in a llama (Lama glama).
  • Postmortem examination revealed an infiltrative uterine adenocarcinoma with widespread metastases.
  • The neoplasm completely replaced and infiltrated the myometrium of the uterine body and cervix and metastasized largely to the serosal surfaces of the peritoneal cavity.
  • [MeSH-major] Adenocarcinoma / veterinary. Camelids, New World. Lipomatosis / veterinary. Papillomaviridae / isolation & purification. Papillomavirus Infections / veterinary. Uterine Neoplasms / veterinary

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  • (PMID = 19286516.001).
  • [ISSN] 1040-6387
  • [Journal-full-title] Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • [ISO-abbreviation] J. Vet. Diagn. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral; 0 / Viral Proteins
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38. Lu CC, De-Chuan C, Lee HS, Chu HC: Pure hepatoid adenocarcinoma of the stomach with spleen and lymph-node metastases. Am J Surg; 2010 Apr;199(4):e42-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pure hepatoid adenocarcinoma of the stomach with spleen and lymph-node metastases.
  • The authors report a rare case of hepatoid adenocarcinoma of the stomach, presenting initially with spleen and lymph node metastases.
  • [MeSH-major] Adenocarcinoma / diagnosis. Cardia. Liver Neoplasms / diagnosis. Lymph Nodes / pathology. Splenic Neoplasms / diagnosis. Stomach Neoplasms / diagnosis

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20359564.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha-Fetoproteins; 8001-40-9 / Iodized Oil; 80168379AG / Doxorubicin
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39. Norris WE, Perry JL, Moawad FJ, Horwhat JD: An unusual presentation of metastatic esophageal adenocarcinoma presenting as thigh pain. J Gastrointestin Liver Dis; 2009 Sep;18(3):371-4
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  • [Title] An unusual presentation of metastatic esophageal adenocarcinoma presenting as thigh pain.
  • The association between esophageal adenocarcinoma and distant skeletal muscle metastasis is extremely rare.
  • Endoscopic biopsy showed poorly differentiated adenocarcinoma.
  • Final diagnosis was primary esophageal adenocarcinoma with distant metastasis to the right ileum and iliacus muscle.
  • We review distinctions between esophageal adenocarcinoma and adenocarcinoma of the gastroesophageal junction.
  • [MeSH-major] Adenocarcinoma / pathology. Esophageal Neoplasms / pathology. Muscle, Skeletal / pathology. Pain / etiology

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  • (PMID = 19795036.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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40. Vesić S, Daković Z, Vukićević J, Vuković J, Stojković J, Medenica L: [Dermatomyositis associated with metastatic rectal adenocarcinoma: case report]. Med Pregl; 2009 Sep-Oct;62(9-10):473-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Dermatomyositis associated with metastatic rectal adenocarcinoma: case report].
  • Association of dermatomyositis with malignant conditions has been described in various studies.
  • We present a patient with paraneoplastic dermatomyositis associated with metastatic rectal adenocarcinoma.
  • According to the medical documents and history, he underwent surgery because of rectal adenocarcinoma in April 2006.
  • The diagnosis of dermatomyositis was based on: characteristic clinical picture; the elevated serum level of following enzymes: creatinine kinase, lactate dehydrogenase; the presence of anti-Mi 2 antibodies in serum; electromyographic finding; and by histology of the muscle biopsy.
  • Paraneoplastic nature of dermatomyositis was confirmed by computer tomography of the abdomen which revealed multiple deposits in the liver, by explorative laparotomy showing peritoneal dissemination and histopathological analysis that verified metastatic adenocarcinoma of the rectum.
  • CONCLUSION: We report a case of paraneoplastic dermatomyositis associated with metastatic rectal adenocarcinoma and lethal outcome, and suggest a comprehensive evaluation of patients with dermatomyositis older than 50 years in order to exclude or verify the occult malignancy.
  • [MeSH-major] Adenocarcinoma / secondary. Dermatomyositis / complications. Paraneoplastic Syndromes / complications. Rectal Neoplasms / complications
  • [MeSH-minor] Aged. Humans. Liver Neoplasms / complications. Liver Neoplasms / secondary. Male. Peritoneal Neoplasms / secondary

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  • (PMID = 20391745.001).
  • [ISSN] 0025-8105
  • [Journal-full-title] Medicinski pregled
  • [ISO-abbreviation] Med. Pregl.
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia
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41. Liu KT, Chan HM, Lin TJ: An unusual presentation of metastatic gastric adenocarcinoma--acute onset of right neck swelling. J Formos Med Assoc; 2007 Jul;106(7):589-91
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  • [Title] An unusual presentation of metastatic gastric adenocarcinoma--acute onset of right neck swelling.
  • Fluid accumulation over deep neck space led to the diagnosis of suspected hemorrhage, and central venous thrombosis was found by computed tomography.
  • Elevated serum tissue polypeptide antigen and CA130 were noted, and multiple liver metastases were found by another computed tomography.
  • Subsequently, gastric adenocarcinoma was confirmed after gastroendoscopy.
  • Gastric adenocarcinoma with distal metastases was finally diagnosed.
  • Malignancy, including gastric adenocarcinoma, is one of the causes that should be considered.

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  • (PMID = 17660150.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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42. van den Bos IC, Hussain SM, Dwarkasing RS, Stoop H, Zondervan PE, Krestin GP, de Man RA: Hepatoid adenocarcinoma of the gallbladder: a mimicker of hepatocellular carcinoma. Br J Radiol; 2007 Dec;80(960):e317-20
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  • [Title] Hepatoid adenocarcinoma of the gallbladder: a mimicker of hepatocellular carcinoma.
  • We present a case of a large gallbladder tumour in a patient with no known liver disease and elevated alpha-fetoprotein (AFP), in whom a differential diagnosis from hepatocellular carcinoma (HCC) in a non-cirrhotic liver was particularly difficult given the combination of the size of the tumour, solitary nature, elevated AFP and striking resemblance with HCC at histology.
  • In presenting this patient, we would like to emphasise the role of MRI as a problem-solving tool for analysis of rare tumours of non-hepatocellular origin, including hepatoid adenocarcinoma of the gallbladder.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Hepatocellular / diagnosis. Gallbladder Neoplasms / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Middle Aged

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  • (PMID = 18065642.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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43. Zhang S, Wang M, Xue YH, Chen YP: Cerebral metastasis from hepatoid adenocarcinoma of the stomach. World J Gastroenterol; 2007 Nov 21;13(43):5787-93
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  • [Title] Cerebral metastasis from hepatoid adenocarcinoma of the stomach.
  • We first report a rare case of metastasis from gastric hepatoid adenocarcinoma (HAC) to cerebral parenchyma, in a 50-year-old Chinese patient.
  • Three years ago, the patient accepted total gastrectomy as he was pathologically diagnosed at gastroscopy having an adenocarcinoma.
  • Eight months after gastrectomy, the occupying lesion in liver was detected by ultrasound and CT, and he accepted transcatheter arterial embolization.
  • Before operation of the brain metastasis, no obvious abnormality was found in liver by ultrasound.
  • Immunohistochemistry-stained tumor cells were positive for AFP and negative for Hep-Par-1.
  • The differential diagnosis of brain metastasis from metastatic tumors should use a panel of antibodies to avoid confusing with the brain metastasis of hepatocellular carcinoma (HCC).
  • This paper describes this rare case of metastasis from gastric hepatoid adenocarcinoma to cerebral parenchyma, and provides a review of the literature concerning its histopathological and immunohistochemical characteristics.
  • [MeSH-major] Adenocarcinoma / secondary. Brain Neoplasms / secondary. Stomach Neoplasms / pathology
  • [MeSH-minor] Carcinoma, Hepatocellular / diagnosis. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 17963312.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4171272
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44. Kim JH, Choi EK, Yoon HK, Ko GY, Sung KB, Gwon DI: Transcatheter arterial chemoembolization for hepatic recurrence after curative resection of pancreatic adenocarcinoma. Gut Liver; 2010 Sep;4(3):384-8

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  • [Title] Transcatheter arterial chemoembolization for hepatic recurrence after curative resection of pancreatic adenocarcinoma.
  • BACKGROUND/AIMS: Despite curative resection, hepatic recurrences cause a significant reduction in survival in patients with primary pancreatic adenocarcinoma.
  • Transcatheter arterial chemoembolization (TACE) has recently been used successfully to treat primary and secondary hepatic malignancy.
  • METHODS: Between 2003 and 2008, 15 patients underwent TACE because of hepatic recurrence after curative resection of a pancreatic adenocarcinoma.
  • The remaining five patients demonstrated continued progression of hypovascular hepatic lesions.
  • The median survival periods from the time of diagnosis and from the time of initial TACE were 9.6 and 7.5 months, respectively.
  • CONCLUSIONS: TACE may represent a viable therapeutic modality in patients with hepatic recurrence after curative resection of pancreatic adenocarcinoma.

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  • (PMID = 20981218.001).
  • [ISSN] 2005-1212
  • [Journal-full-title] Gut and liver
  • [ISO-abbreviation] Gut Liver
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2956353
  • [Keywords] NOTNLM ; Liver / Pancreatic adenocarcinoma / Transcatheter arterial chemoembolization
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45. Foo FY, Lee M, Looi A: Asymptomatic pancreatic adenocarcinoma presenting as an orbital metastatic tumor. Orbit; 2010 Oct;29(5):262-5
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  • [Title] Asymptomatic pancreatic adenocarcinoma presenting as an orbital metastatic tumor.
  • We report a rare case, with clinicopathological correlation, of metastatic pancreatic adenocarcinoma, presenting first in the orbit with symptoms of diplopia, blurring of vision and supraorbital ache.
  • Excisional biopsy was performed and histopathology confirmed a metastatic adenocarcinoma.
  • Subsequent gastrointestinal imaging and tumor markers revealed an asymptomatic pancreatic adenocarcinoma, with multiple liver metastases.
  • Our patient developed hepatobiliary sepsis and passed away 44 days after diagnosis.
  • [MeSH-major] Adenocarcinoma / secondary. Orbital Neoplasms / secondary. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Diplopia / diagnosis. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed. Vision Disorders / diagnosis

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  • (PMID = 20704487.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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46. Chapman C, Aboulafia DM, Dezube BJ, Pantanowitz L: Human immunodeficiency virus-associated adenocarcinoma of the colon: clinicopathologic findings and outcome. Clin Colorectal Cancer; 2009 Oct;8(4):215-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Human immunodeficiency virus-associated adenocarcinoma of the colon: clinicopathologic findings and outcome.
  • BACKGROUND: Patients infected with Human immunodeficiency virus (HIV) living longer with antiretroviral therapy (ART) are more likely to develop non-AIDS-defining cancers such as adenocarcinoma of the colon.
  • There have been limited case reports regarding HIV-associated colon adenocarcinoma.
  • The aim of this study was to characterize the clinicopathologic findings and outcome in a series of HIV-infected patients diagnosed and treated for colon adenocarcinoma.
  • PATIENTS AND METHODS: A retrospective study involving HIV-related colon adenocarcinoma was performed.
  • Most carcinomas (57%) involved the right colon, were largely TNM stage 4 cancers (47%), and, when present, metastases were mainly to the liver.
  • Many (47%) individuals died within 1-26 months after their cancer diagnosis.
  • Immunosuppression (AIDS diagnosis and/or CD4+ < 500 cells/mm3) did not appear to correlate with tumor grade, stage, or an adverse outcome.
  • CONCLUSION: These data show that HIV-infected patients with adenocarcinoma of the colon tend to be young men with a high incidence of right-sided involvement.
  • [MeSH-major] Adenocarcinoma / complications. Colonic Neoplasms / complications. HIV Infections / complications

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  • (PMID = 19822512.001).
  • [ISSN] 1533-0028
  • [Journal-full-title] Clinical colorectal cancer
  • [ISO-abbreviation] Clin Colorectal Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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47. Bacigalupo L, Aufort S, Eberlé MC, Assenat E, Ychou M, Gallix B: Assessment of liver metastases from colorectal adenocarcinoma following chemotherapy: SPIO-MRI versus FDG-PET/CT. Radiol Med; 2010 Oct;115(7):1087-100
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  • [Title] Assessment of liver metastases from colorectal adenocarcinoma following chemotherapy: SPIO-MRI versus FDG-PET/CT.
  • PURPOSE: This study compared superparamagnetic iron-oxide-enhanced magnetic resonance imaging (SPIO-MRI) and combined fluorodeoxyglucose positron emission tomography and computed tomography (FDG-PET/CT) in evaluating liver metastases from colorectal adenocarcinoma following chemotherapy.
  • CONCLUSIONS: SPIO-MRI appears superior to PET/CT in evaluating liver metastases from colorectal adenocarcinoma following chemotherapy.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Colorectal Neoplasms / pathology. Contrast Media. Ferrosoferric Oxide. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Magnetic Resonance Imaging. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 20574703.001).
  • [ISSN] 1826-6983
  • [Journal-full-title] La Radiologia medica
  • [ISO-abbreviation] Radiol Med
  • [Language] eng; ita
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18; XM0M87F357 / Ferrosoferric Oxide
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48. Djuranovic SP, Spuran MM, Kovacevic NV, Ugljesic MB, Kecmanovic DM, Micev MT: Mucinous cystadenoma of the appendix associated with adenocarcinoma of the sigmoid colon and hepatocellular carcinoma of the liver: report of a case. World J Gastroenterol; 2006 Mar 28;12(12):1975-7
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  • [Title] Mucinous cystadenoma of the appendix associated with adenocarcinoma of the sigmoid colon and hepatocellular carcinoma of the liver: report of a case.
  • This condition is often associated with other neoplasia, especially adenocarcinoma of the colon and ovaries.
  • He had a big cystadenoma of the appendix associated with adenocarcinoma of the colon and hepatocellular carcinoma of the liver.
  • The patient underwent right haemicolectomy, sigmoid colon resection and segmental resection of the liver.
  • According to this, we stress the need of accurate preoperative diagnosis and intraoperative exploration of the whole abdomen in these patients.
  • [MeSH-major] Adenocarcinoma / complications. Appendiceal Neoplasms / complications. Carcinoma, Hepatocellular / complications. Cystadenoma, Mucinous / complications. Liver Neoplasms / complications. Sigmoid Neoplasms / complications

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  • (PMID = 16610012.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4087531
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49. An M, Shin JA, Lee SM, Yoon T, Park WS, Choi JI, Kim CM: [Liver metastasis of colon cancer with a high serum alpha-fetoprotein level: report of a case]. Korean J Hepatol; 2006 Dec;12(4):562-7
MedlinePlus Health Information. consumer health - Liver Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Liver metastasis of colon cancer with a high serum alpha-fetoprotein level: report of a case].
  • We report herein a case of 72-year-old woman in whom liver metastasis of colon cancer was presented with a marked elevation of serum alpha-fetoprotein (AFP) level.
  • She was transferred to our hospital for multiple liver masses found on ultrasonogram.
  • Abdominal computed tomogram revealed multiple low-density masses in the liver and wall thickening of the hepatic flexure of colon.
  • Colonoscopic findings of ulcerofungating mass suggested liver metastasis from colon cancer.
  • Both colon and liver biopsies revealed moderately differentiated tubular adenocarcinoma.
  • Using an immunohistochemical staining, the adenocarcinoma in liver showed focal positive to AFP, but not in colon.
  • [MeSH-major] Colonic Neoplasms / pathology. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. alpha-Fetoproteins / analysis

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  • (PMID = 17237635.001).
  • [ISSN] 1738-222X
  • [Journal-full-title] The Korean journal of hepatology
  • [ISO-abbreviation] Korean J Hepatol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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50. Geramizadeh B, Boub R, Rahsaz M: Histologic differentiation of hepatocellular carcinoma from adenocarcinoma by a simple panel: evaluation of the pitfalls. Indian J Pathol Microbiol; 2007 Jul;50(3):507-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histologic differentiation of hepatocellular carcinoma from adenocarcinoma by a simple panel: evaluation of the pitfalls.
  • The histological differentiation of Hepatocellular carcinoma (HCC) from cholangiocarcinoma (CC) and metastatic adenocarcinoma (MA) of the liver is difficult in some cases and immunohistochemistry (IHC) is necessary for the diagnosis.
  • HepPar-1 is a recently available antibody which seems to be very specific and sensitive for the diagnosis of HCC.
  • In this study we tried to apply these two markers for the diagnosis of HCC cases as a simple, useful and reliable panel.
  • We selected 101 liver tumors which had proven diagnosis by several antibodies and cilinicopathologic correlation.
  • The tumors with confirmed histologic diagnosis including 35 HCC, 58 MA, 7 CC and 1 combined HCC-CC.. HepPar-1 was positive in 30 of 35 cases of HCC; none of the other tumors were reactive for HepPar1 except for a case of metastatic gall bladder adenocarcinoma which showed areas of hepatoid differentiation in the H&E slides.
  • These two reliable markers are recommended for the initial step of differential diagnosis between HCC and MA and for the confirmation of the histologic diagnosis.
  • [MeSH-major] Adenocarcinoma / secondary. Antibodies, Monoclonal. Carcinoma, Hepatocellular / diagnosis. Cholangiocarcinoma / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / immunology. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Immunohistochemistry. Membrane Glycoproteins / immunology. Middle Aged

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  • (PMID = 17883119.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; 0 / Membrane Glycoproteins
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51. Overman MJ: Recent advances in the management of adenocarcinoma of the small intestine. Gastrointest Cancer Res; 2009 May;3(3):90-6
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  • [Title] Recent advances in the management of adenocarcinoma of the small intestine.
  • Adenocarcinoma of the small intestine is a rare malignancy with limited data available to guide therapeutic decisions.
  • Delays in diagnosis are frequent and the majority of patients will present with advanced-stage disease and either lymph node involvement or distant metastatic disease.
  • Recent retrospective and prospective studies have helped to clarify the optimal chemotherapy approach for advanced small bowel adenocarcinoma.
  • This article reviews the clinical features and evaluation of patients with small bowel adenocarcinoma and focuses on recent advances in management.

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  • (PMID = 19626152.001).
  • [ISSN] 1934-7820
  • [Journal-full-title] Gastrointestinal cancer research : GCR
  • [ISO-abbreviation] Gastrointest Cancer Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2713134
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52. Kinugasa Y, Morishige K, Kamiura S, Tsukamoto Y, Saji F: Parathyroid hormone-related protein-secreting uterine endometrioid adenocarcinoma. Jpn J Clin Oncol; 2006 Feb;36(2):113-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parathyroid hormone-related protein-secreting uterine endometrioid adenocarcinoma.
  • The diagnosis of parathyroid hormone-related protein (PTHrP)-secreting metastatic uterine endometrioid cancer was made in a 32-year-old Japanese woman with humoral hypercalcemia of malignancy.
  • The primary endometrial cancer had been removed, and the tumor was diagnosed as Grade 1 endometrioid adenocarcinoma with shallow myometrial invasion.
  • Salvage chemotherapy (paclitaxel and calboplatin) was started from 5 months after surgery when recurrent tumors were detected in the peritoneum and liver.
  • To the best of our knowledge, this is the first reported case of hypercalcemia due to PTHrP secretion in uterine endometrioid adenocarcinoma.

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  • (PMID = 16418186.001).
  • [ISSN] 0368-2811
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Parathyroid Hormone-Related Protein
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53. Kato K, Sugimoto H, Kanazumi N, Nomoto S, Takeda S, Nakao A: Intra-operative application of real-time tissue elastography for the diagnosis of liver tumours. Liver Int; 2008 Nov;28(9):1264-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intra-operative application of real-time tissue elastography for the diagnosis of liver tumours.
  • The aim of this study was to evaluate the usefulness of RTE for the differential diagnosis of liver tumours during surgical exploration.
  • METHODS: Fifty-five liver tumours in 44 patients were examined with RTE, concomitant with routine intra-operative ultrasonography.
  • Elasticity images were classified into four types, from type A (even strain) to type D (no strain), according to the distribution and the degree of the strain contrasted with that of the surrounding liver [elasticity type of liver tumour (ETLT)].
  • We evaluated the consistency of the findings of RTE with the pathological diagnosis as a reference standard.
  • RESULTS: All malignant lesions showed various degrees of strain reduction in the tumour tissue.
  • CONCLUSION: Application of RTE in surgical exploration provided significant information about the elasticity of liver tumours.
  • RTE, using a new criterion, ETLT, enabled us to distinguish rather accurately between two common malignancies: HCC and metastatic adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Elasticity Imaging Techniques. Liver Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Intraoperative Care. Liver / pathology. Liver / surgery. Liver / ultrasonography. Male. Middle Aged. Prospective Studies

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  • (PMID = 18331239.001).
  • [ISSN] 1478-3231
  • [Journal-full-title] Liver international : official journal of the International Association for the Study of the Liver
  • [ISO-abbreviation] Liver Int.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] England
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54. Karasavvidou F, Potamianos SP, Barbanis S, Stathakis E, Psychos A, Kapsoritakis AN, Koukoulis G: Malakoplakia of the colon associated with colonic adenocarcinoma diagnosed in colonic biopsies. World J Gastroenterol; 2007 Dec 7;13(45):6109-11
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  • [Title] Malakoplakia of the colon associated with colonic adenocarcinoma diagnosed in colonic biopsies.
  • It has also been found in many other sites such as the gastrointestinal tract, pancreas, liver, lymph nodes, skin, respiratory tract, adrenal gland, vagina and brain.
  • We present a case of a 64-year-old man referred to our hospital with cachexia and radiologic evidence of metastatic tumor of the liver.
  • Colonoscopy revealed a large malignant - appearing polypoid mass of the ascending colon and multiple distinct polyps throughout the rest of the colon.
  • Biopsies of the ascending colon mass confirmed the diagnosis of adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / complications. Colonic Neoplasms / complications. Malacoplakia / complications

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  • (PMID = 18023111.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4250902
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55. Takamori H, Kanemitsu K, Tsuji T, Kusano S, Chikamoto A, Okuma T, Iyama K: Metastatic gastric tumor secondary to pancreatic adenocarcinoma. J Gastroenterol; 2005 Feb;40(2):209-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic gastric tumor secondary to pancreatic adenocarcinoma.
  • Local recurrence, liver metastases, and peritoneal spread are the most common recurrent patterns after curative resection of pancreatic cancer.
  • We report a patient who suffered from gastric metastasis secondary to pancreatic adenocarcinoma 1 year after pancreatectomy.
  • The histological diagnosis was well-differentiated adenocarcinoma of the pancreas, stage IIB; T1N1M0.
  • Multiple liver metastases were detected on computed tomography (CT) in March 2003.
  • Combination chemotherapy of 5-fluorouracil hepatic arterial continuous infusion and systemic gemcitabine administration led to the disappearance of the liver metastases on CT in September 2003.
  • Histological diagnosis of the biopsy specimen was well-differentiated adenocarcinoma, and immunohistochemical studies, using anti-cytokeratin 7 and -20 monoclonal antibodies, were compatible with gastric metastasis from pancreatic carcinoma.
  • Histopatholoical examination of the resected specimen revealed submucosal growth of the metastatic cancer (well-differentiated adenocarcinoma).
  • [MeSH-major] Adenocarcinoma / secondary. Pancreatic Neoplasms / pathology. Stomach Neoplasms / secondary

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  • (PMID = 15770407.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / CA-19-9 Antigen
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56. Karabork A, Kaygusuz G, Ekinci C: The best immunohistochemical panel for differentiating hepatocellular carcinoma from metastatic adenocarcinoma. Pathol Res Pract; 2010 Aug 15;206(8):572-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The best immunohistochemical panel for differentiating hepatocellular carcinoma from metastatic adenocarcinoma.
  • It can be difficult to differentiate hepatocellular carcinoma (HCC) from metastatic adenocarcinoma (MA).
  • An appropriate immunohistochemical panel is required for the differential diagnosis.
  • [MeSH-major] Adenocarcinoma / secondary. Biomarkers, Tumor / analysis. Carcinoma, Hepatocellular / pathology. Immunohistochemistry / methods. Liver Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Tissue Array Analysis

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  • (PMID = 20400233.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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57. Chen JJ, Ong SL, Richards C, Garcea G, Pollard C, Berry D, Dennison A: Inaccuracy of fine-needle biopsy in the diagnosis of solitary fibrous tumour of the liver. Asian J Surg; 2008 Oct;31(4):195-8
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  • [Title] Inaccuracy of fine-needle biopsy in the diagnosis of solitary fibrous tumour of the liver.
  • Solitary fibrous tumour (SFT) is an uncommon neoplasm of mesenchymal origin that primarily affects the pleura and mediastinum.
  • SFTs may occur elsewhere in the body including the liver, peritoneum, orbit and other soft tissues.
  • Nevertheless, radiologically it remains difficult to distinguish SFTs of the liver from other solitary tumours as they have many common features.
  • We report a case of SFT of the liver and highlight the potential inaccuracy of percutaneous biopsy in the diagnosis of large solitary liver tumours.

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  • (PMID = 19010762.001).
  • [ISSN] 1015-9584
  • [Journal-full-title] Asian journal of surgery
  • [ISO-abbreviation] Asian J Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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58. Agrawal S, McCarron EC, Gibbs JF, Nava HR, Wilding GE, Rajput A: Surgical management and outcome in primary adenocarcinoma of the small bowel. Ann Surg Oncol; 2007 Aug;14(8):2263-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical management and outcome in primary adenocarcinoma of the small bowel.
  • BACKGROUND: Primary adenocarcinoma of the small bowel is a rare malignancy and is associated with poor survival outcome.
  • METHODS: Between 1971 and 2005, 64 patients with primary adenocarcinoma of the small bowel were treated at our institution.
  • The most common sites of recurrence following a curative resection were the liver and lung.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / pathology. Intestinal Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Middle Aged. Multivariate Analysis. Neoplasm Recurrence, Local. Neoplasm Staging. Prognosis. Survival Rate. Time Factors. Treatment Outcome

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  • (PMID = 17549572.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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59. Pai MR, Mathai AM, Kumar S, Prabhu S: Coexistent gastric primary choriocarcinoma and adenocarcinoma. Indian J Pathol Microbiol; 2009 Oct-Dec;52(4):537-9
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  • [Title] Coexistent gastric primary choriocarcinoma and adenocarcinoma.
  • We herein describe a case of primary gastric choriocarcinoma with liver metastasis in a 69-year-old male.
  • The histopathologic findings of the resected tumor were that of an extensively necrotic and hemorrhagic neoplasm with combined choriocarcinomatous and adenocarcinomatous element.
  • A strongly positive immunohistochemical staining for beta- subunit of human chorionic gonadotropin (beta-HCG) in the choriocarcinomatous component and a proper correlation with elevated serum beta-HCG levels confirmed the diagnosis.
  • [MeSH-major] Adenocarcinoma / complications. Adenocarcinoma / diagnosis. Choriocarcinoma / complications. Choriocarcinoma / diagnosis. Stomach Neoplasms / diagnosis. Stomach Neoplasms / pathology
  • [MeSH-minor] Aged. Chorionic Gonadotropin, beta Subunit, Human / analysis. Histocytochemistry. Humans. Immunohistochemistry. Liver Neoplasms / pathology. Liver Neoplasms / secondary. Male. Pyloric Antrum / pathology. Pylorus / pathology. Radiography, Abdominal

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  • (PMID = 19805966.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin, beta Subunit, Human
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60. Bir A, Bshara W, George M, Fakih MG: Idiopathic thrombocytopenic purpura in a newly diagnosed pancreatic adenocarcinoma. JOP; 2006;7(6):647-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Idiopathic thrombocytopenic purpura in a newly diagnosed pancreatic adenocarcinoma.
  • CONTEXT: Pancreatic adenocarcinoma presenting as idiopathic thrombocytopenic purpura has not been previously reported in the literature.
  • CASE REPORT: A newly diagnosed patient with metastatic pancreatic adenocarcinoma developed thrombocytopenic purpura prior to initiation of chemotherapy.
  • CONCLUSIONS: ITP can be associated with metastatic pancreatic adenocarcinoma and can respond well to steroid treatment.
  • [MeSH-major] Adenocarcinoma / complications. Pancreatic Neoplasms / complications. Purpura, Thrombocytopenic, Idiopathic / complications. Purpura, Thrombocytopenic, Idiopathic / diagnosis
  • [MeSH-minor] Blood Platelets / cytology. Female. Humans. Liver Neoplasms / pathology. Liver Neoplasms / secondary. Middle Aged. Platelet Count

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  • (PMID = 17095846.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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61. Petersen M, Meyer F, Kalinski T, Bischoff J, Bohr UR, Lippert H: [Rare neuroendocrine carcinoma of the gall bladder. Coincidental occurrence of an endometrioid ovarian adenocarcinoma]. Dtsch Med Wochenschr; 2009 Jan;134(1-2):19-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Rare neuroendocrine carcinoma of the gall bladder. Coincidental occurrence of an endometrioid ovarian adenocarcinoma].
  • [Transliterated title] Seltenes neuroendokrines Karzinom der Gallenblase. Abgrenzung zur metachronen Koinzidenz mit einem endometrioiden Adenokarzinom des Ovars.
  • DIAGNOSIS: The tumor lesion within the gall bladder and lymph node was classified as a neuroendocrine carcinoma, not a metastasis of the ovarian carcinoma.
  • TREATMENT AND CLINICAL COURSE: The patient underwent another laparotomy with resection of the stump of the cystic duct and the liver parenchyma surrounding the former gall bladder, including dissection of the lymph nodes within the hepatoduodenal ligament.
  • But for eight years there has been no recurrence of the endometrioid adenocarcinoma of the left ovary.
  • CONCLUSION: Because of the increasing incidence of malignant diseases and second neoplasms there is a growing need for such diagnostic tests as histological and immunohistochemical analysis.
  • This is the first case, according to the available literature, of an endometrioid adenocarcinoma of the ovary concomitant with a neuroendocrine carcinoma of the gall bladder.
  • [MeSH-major] Carcinoma, Endometrioid / diagnosis. Carcinoma, Neuroendocrine / diagnosis. Gallbladder Neoplasms / diagnosis. Neoplasms, Second Primary / diagnosis. Ovarian Neoplasms / diagnosis
  • [MeSH-minor] Aged. Chemotherapy, Adjuvant. Cholecystectomy, Laparoscopic. Female. Humans. Immunohistochemistry. Lymphatic Metastasis. Neoplasm Recurrence, Local / therapy

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  • [ErratumIn] Dtsch Med Wochenschr. 2019 Sep;134(39):1915
  • (PMID = 19090447.001).
  • [ISSN] 1439-4413
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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62. Sohda T, Tomioka Y, Inomata S, Morita I, Eguchi K, Aoyagi K, Watanabe H, Nakamura S, Sakisaka S: Alpha-fetoprotein (AFP)- and des-gamma-carboxy prothrombin (DCP)-producing adenocarcinoma of the stomach with liver metastasis in a patient with chronic hepatitis C. Intern Med; 2005 Apr;44(4):294-8
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  • [Title] Alpha-fetoprotein (AFP)- and des-gamma-carboxy prothrombin (DCP)-producing adenocarcinoma of the stomach with liver metastasis in a patient with chronic hepatitis C.
  • A 45-year-old man was admitted to our hospital because of chronic hepatitis C and a large liver tumor accompanied by increased serum levels of alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP), the tumor markers for hepatocellular carcinoma.
  • Biopsy specimens of the stomach and liver showed gastric adenocarcinoma and its metastasis to the liver.
  • Immunohistochemical studies demonstrated that adenocarcinoma cells both of the stomach and liver, were positive for the antibodies against AFP as well as DCP.
  • Accordingly, we diagnosed this patient with AFP- and DCP-producing adenocarcinoma of the stomach together with liver metastasis.
  • [MeSH-major] Adenocarcinoma / secretion. Biomarkers / blood. Hepatitis C, Chronic / complications. Liver Neoplasms / secondary. Protein Precursors / blood. Stomach Neoplasms / secretion. alpha-Fetoproteins / metabolism
  • [MeSH-minor] Biomarkers, Tumor / blood. Biopsy. Diagnosis, Differential. Fatal Outcome. Follow-Up Studies. Gastroscopy. Gene Expression Regulation, Neoplastic. Humans. Male. Middle Aged. Prothrombin / genetics. RNA, Messenger / genetics. Tomography, X-Ray Computed

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  • (PMID = 15897638.001).
  • [ISSN] 0918-2918
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Biomarkers, Tumor; 0 / Protein Precursors; 0 / RNA, Messenger; 0 / alpha-Fetoproteins; 53230-14-1 / acarboxyprothrombin; 9001-26-7 / Prothrombin
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63. Lee HJ, Cha JM, Lee JI, Joo KR, Jung SW, Shin HP: A case of jejunal adenocarcinoma diagnosed by preoperative double balloon enteroscopy. Gut Liver; 2009 Dec;3(4):311-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of jejunal adenocarcinoma diagnosed by preoperative double balloon enteroscopy.
  • Despite a thorough history, physical examination, and complete diagnostic workup, the correct diagnosis of small-intestinal malignancy is established preoperatively in only 50% of cases; an exploratory laparotomy is often required.
  • However, recent advances in endoscopic technologies, such as double-balloon enteroscopy (DBE), have been shown to facilitate the preoperative diagnosis of these tumors.
  • We describe herein the case of a 53-year-old woman with a stage I jejunal adenocarcinoma that was diagnosed by DBE and treated by laparoscopic jejunectomy.
  • Histopathological examination revealed a stage I jejunal adenocarcinoma (T2N0M0) without muscularis propria invasion, lymphovascular invasion, or lymph-node metastasis.

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  • (PMID = 20431766.001).
  • [ISSN] 2005-1212
  • [Journal-full-title] Gut and liver
  • [ISO-abbreviation] Gut Liver
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2852726
  • [Keywords] NOTNLM ; Adenocarcinoma / Double ballon enteroscopy / Jejunum
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64. Rossi E, Villanacci V, Bassotti G, Donato F, Festa A, Cengia G, Grisanti S, Cestari R: TOPOIIalpha and HER-2/neu overexpression/amplification in Barrett's oesophagus, dysplasia and adenocarcinoma. Histopathology; 2010 Jul;57(1):81-9
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  • [Title] TOPOIIalpha and HER-2/neu overexpression/amplification in Barrett's oesophagus, dysplasia and adenocarcinoma.
  • AIMS: Topoisomerase IIalpha (TOPOIIalpha) and HER-2/neu are chromosome 17q genes coamplified in various cancers; no data exist for Barrett's oesophagus (BO) and BO adenocarcinoma (ADC).
  • [MeSH-major] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Antigens, Neoplasm / genetics. Barrett Esophagus / genetics. Barrett Esophagus / pathology. DNA Topoisomerases, Type II / genetics. DNA-Binding Proteins / genetics. Esophageal Neoplasms / genetics. Esophageal Neoplasms / pathology. Genes, erbB-2
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Aneuploidy. Chromosomes, Human, Pair 17 / genetics. Diagnosis, Differential. Female. Gene Amplification. Gene Expression. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged. Receptor, ErbB-2 / metabolism. Retrospective Studies

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  • (PMID = 20557373.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / DNA-Binding Proteins; EC 2.7.10.1 / ERBB2 protein, human; EC 2.7.10.1 / Receptor, ErbB-2; EC 5.99.1.3 / DNA Topoisomerases, Type II; EC 5.99.1.3 / DNA topoisomerase II alpha
  • [Other-IDs] NLM/ PMC2916224
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65. Mason AC, Azari KK, Farkas LM, Duvvuri U, Myers EN: Metastatic adenocarcinoma of the colon presenting as a mass in the mandible. Head Neck; 2005 Aug;27(8):729-32

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic adenocarcinoma of the colon presenting as a mass in the mandible.
  • BACKGROUND: Metastatic adenocarcinoma of the colon is a frequently encountered medical situation.
  • Metastasis to the mandible from adenocarcinoma of the colon is very unusual and rarely reported.
  • We report the case of a 73-year-old man with metastatic adenocarcinoma to the mandible.
  • CT scans of the abdomen and pelvis revealed a 5-cm mass in the sigmoid colon with metastases to the liver.
  • RESULTS: A biopsy of the mass in the mandible was performed, and metastatic adenocarcinoma of colonic origin was diagnosed.
  • CONCLUSIONS: Although rare, metastatic adenocarcinoma from the colon to the mandible and parotid area should be included in the differential diagnosis of masses in this area.
  • After analysis of our case and a review of the literature, we conclude that metastasis from adenocarcinoma of the colon is quite rare and represents incurable disseminated disease.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Mandibular Neoplasms / diagnosis. Mandibular Neoplasms / secondary. Sigmoid Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy. Colon, Sigmoid / radiography. Cranial Fossa, Middle. Diagnosis, Differential. Endoscopy. Fatal Outcome. Humans. Liver Neoplasms / secondary. Male. Mandible / pathology. Mandible / radiography. Pterygoid Muscles. Tomography, X-Ray Computed

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  • [Copyright] Copyright 2005 Wiley Periodicals, Inc.
  • (PMID = 15920751.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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66. Gálvez-Muñoz E, Gallego-Plazas J, Gonzalez-Orozco V, Menarguez-Pina F, Ruiz-Maciá JA, Morcillo MA: Hepatoid adenocarcinoma of the stomach - a different histology for not so different gastric adenocarcinoma: a case report. Int Semin Surg Oncol; 2009;6:13

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hepatoid adenocarcinoma of the stomach - a different histology for not so different gastric adenocarcinoma: a case report.
  • Hepatoid adenocarcinoma is an extrahepatic tumor characterized by morphological similarities to hepatocellular carcinoma.
  • Hepatoid adenocarcinoma of the stomach is a cancer with an extremely poor prognosis with few cases reported.
  • Initial study revealed anemia, and computed tomography scan and abdominal ultrasonography showed multiple metastases to the liver with hepatocellular carcinoma characteristics in a liver with no cirrhotic change.
  • Gastric biopsies of the tumor revealed poorly differenciated adenocarcinoma, with hepatoid differentiation.
  • After a diagnosis of AFP-producing hepatoid adenocarcinoma of the stomach with multiple liver metastases was made, pallitive total gastrectomy, without liver resection, was performed.
  • Accurate diagnosis of hepatoid adenocarcinoma of the stomach is important, and should be suspected under certain circumstances.
  • We describe this rare case of hepatoid adenocarcinoma of the stomach, and review the literature concerning the clinicopathological aspects.

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  • (PMID = 19674468.001).
  • [ISSN] 1477-7800
  • [Journal-full-title] International seminars in surgical oncology : ISSO
  • [ISO-abbreviation] Int Semin Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2731104
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67. Walker M, Radley S: Adenocarcinoma in an ileoanal pouch formed for ulcerative colitis in a patient with primary sclerosing cholangitis and a liver transplant: report of a case and review of the literature. Dis Colon Rectum; 2006 Jun;49(6):909-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma in an ileoanal pouch formed for ulcerative colitis in a patient with primary sclerosing cholangitis and a liver transplant: report of a case and review of the literature.
  • This is a report of the first case of adenocarcinoma arising in an ileal pouch after proctocolectomy for ulcerative colitis in a patient who had also undergone orthotopic liver transplantation for primary sclerosing cholangitis.
  • Previously reported cases of adenocarcinoma developing after formation of an ileoanal pouch are reviewed as is the evidence for neoplastic transformation of the ileal mucosa.
  • [MeSH-major] Adenocarcinoma / diagnosis. Colitis, Ulcerative / surgery. Colonic Pouches. Colorectal Neoplasms / diagnosis. Proctocolectomy, Restorative / adverse effects
  • [MeSH-minor] Cholangitis, Sclerosing / surgery. Humans. Liver Transplantation. Male. Middle Aged


68. Jones-Bolin S, Ruggeri B: Orthotopic model of human pancreatic ductal adenocarcinoma and cancer cachexia in nude mice. Curr Protoc Pharmacol; 2007 Jun;Chapter 14:Unit 14.3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Orthotopic model of human pancreatic ductal adenocarcinoma and cancer cachexia in nude mice.
  • Pancreatic ductal adenocarcinoma (PDAC) represents the fourth leading cause of cancer-related deaths in the United States, with a 5-year survival rate of only 2% to 10%.
  • This tumor is aggressive, often metastasizing to distant sites (liver, lung, and adjacent intestines) by the time of diagnosis.
  • It is characterized by diffuse peritoneal, lymphatic, and hepatic metastatic spread and manifestations of a cancer cachexic phenotype.

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  • (PMID = 21948162.001).
  • [ISSN] 1934-8290
  • [Journal-full-title] Current protocols in pharmacology
  • [ISO-abbreviation] Curr Protoc Pharmacol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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69. Golbar H, Izawa T, Kuwamura M, Ito S, Yamate J: Uterine adenocarcinoma with prominent desmoplasia in a geriatric miniature pig. J Vet Med Sci; 2010 Feb;72(2):253-6
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  • [Title] Uterine adenocarcinoma with prominent desmoplasia in a geriatric miniature pig.
  • Metastatic lesions were seen in the lungs and liver.
  • Based on these findings, a diagnosis of uterine adenocarcinoma with marked desmoplasia was made.
  • This case is the second report of uterine adenocarcinoma in the miniature pig.

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  • (PMID = 19942805.001).
  • [ISSN] 0916-7250
  • [Journal-full-title] The Journal of veterinary medical science
  • [ISO-abbreviation] J. Vet. Med. Sci.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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70. Marini RP, Muthupalani S, Shen Z, Buckley EM, Alvarado C, Taylor NS, Dewhirst FE, Whary MT, Patterson MM, Fox JG: Persistent infection of rhesus monkeys with 'Helicobacter macacae' and its isolation from an animal with intestinal adenocarcinoma. J Med Microbiol; 2010 Aug;59(Pt 8):961-9
SILVA. SILVA SSU Database .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Persistent infection of rhesus monkeys with 'Helicobacter macacae' and its isolation from an animal with intestinal adenocarcinoma.
  • The animal was euthanized and a diagnosis was made of intestinal adenocarcinoma of the ileocaecocolic junction with metastasis to regional lymph nodes and liver.
  • The liver, small intestine and colon were also positive by PCR for Helicobacter species.
  • Intestinal adenocarcinoma is the most common malignancy of aged macaques.
  • The apparent persistence of 'H. macacae' in these animals, the isolation of the bacterium from animals with colitis and the recognition of the importance of inflammation in carcinogenesis raise the possibility of an aetiological role in the genesis of intestinal adenocarcinoma in aged rhesus monkeys.

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  • (PMID = 20413623.001).
  • [ISSN] 1473-5644
  • [Journal-full-title] Journal of medical microbiology
  • [ISO-abbreviation] J. Med. Microbiol.
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / P30 ES002109; United States / NIEHS NIH HHS / ES / P30 ES02109; United States / NCRR NIH HHS / RR / T32 RR007036; United States / NCI NIH HHS / CA / R01 CA 67529; United States / NCRR NIH HHS / RR / T32 RR07036; United States / NCI NIH HHS / CA / R01 CA067529
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Bacterial; 0 / DNA, Ribosomal; 0 / RNA, Ribosomal, 16S
  • [Other-IDs] NLM/ PMC3052472
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71. Jalle T, Gérard C, Lada PE, Sagan C, Gournay J, Arnaud JP, Paineau J, Hamy A: [Hepatoid adenocarcinoma of the stomach. A case report]. Ann Chir; 2006 Mar;131(3):213-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Hepatoid adenocarcinoma of the stomach. A case report].
  • [Transliterated title] Adénocarcinome hépatoïde de l'estomac. A propos d'un cas.
  • Hepatoid adenocarcinoma of the stomach is a very rare tumor with a poor prognosis.
  • Lymph nodes involvement and/or liver metastases are frequently observed.
  • Diagnosis should be pointed out if elevated serum level of alpha-fetoprotein (AFP) is detected with gastric tumor.
  • Histologically, the tumor is an adenocarcinoma of intestinal type including foci of hepatoïd differenciation.
  • We report a case of a 66 year-old man presenting an advanced stage of hepatoid adenocarcinoma of the stomach, treated by gastrectomy followed by chemotherapy.
  • The patient died four months after the surgery because of progressing liver metastatic disease.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Gastrectomy. Stomach Neoplasms / pathology. Stomach Neoplasms / surgery
  • [MeSH-minor] Aged. Chemotherapy, Adjuvant. Fatal Outcome. Humans. Liver Neoplasms / secondary. Male

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  • (PMID = 16293220.001).
  • [ISSN] 0003-3944
  • [Journal-full-title] Annales de chirurgie
  • [ISO-abbreviation] Ann Chir
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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72. Tuncel A, Sezgin T, Uzum N, Ataoglu O, Atan A: Primary apocrine adenocarcinoma of the scrotum with distant metastasis: a case report. Can J Urol; 2009 Oct;16(5):4860-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary apocrine adenocarcinoma of the scrotum with distant metastasis: a case report.
  • Thoraco abdomino pelvic computerized tomography revealed diffuse, multiple and hypodense lesions in the liver parenchyma.
  • In histopathological examination, apocrine adenocarcinoma was diagnosed.
  • [MeSH-major] Adenocarcinoma / secondary. Apocrine Glands. Bone Neoplasms / secondary. Liver Neoplasms / secondary. Scrotum. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Fatal Outcome. Humans. Male. Middle Aged. Tomography, X-Ray Computed. Urologic Surgical Procedures, Male / methods

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  • (PMID = 19796468.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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73. Coevoet H, Woelffle D, Quinton JF, Hector E, Bonnière X, Boruchowicz A: [Distal pancreatectomy for rectal metastatic adenocarcinoma 6 years after proctectomy]. Gastroenterol Clin Biol; 2007 Jun-Jul;31(6-7):624-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Distal pancreatectomy for rectal metastatic adenocarcinoma 6 years after proctectomy].
  • [Transliterated title] Pancréatectomie caudale pour métastase d'un adénocarcinome rectal 6 ans après exérèse de la tumeur primitive.
  • Diagnosis was made based on increased CEA levels following excision of the rectal tumor discovered during treatment follow up of liver and pulmonary metastases.
  • Pancreatic resection for metastatic colonic adenocarcinoma of the pancreas may be considered in selected patients without extrapancreatic disease.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / surgery. Neoplasms, Second Primary / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / secondary. Pancreatic Neoplasms / surgery. Rectal Neoplasms / pathology. Rectal Neoplasms / surgery

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  • (PMID = 17646794.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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74. Kostić Z, Cuk V, Bokun R, Ignjatović D, Usaj-Knezević S, Ignjatović M: [Detection of free cancer cells in peritoneal cavity in patients surgically treated for gastric adenocarcinoma]. Vojnosanit Pregl; 2006 Apr;63(4):349-56
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Detection of free cancer cells in peritoneal cavity in patients surgically treated for gastric adenocarcinoma].
  • BACKGROUND/AIM: Peritoneal metastasis is a leading cause of therapeutic failure after an operative treatment of patients with gastric adenocarcinoma.
  • The aim of this study was to determine the frequency of the presence of free cancer cells in the peritoneal cavity in the patients surgically treated for gastric adenocarcinoma, and its relation to certain clinical, operative and pathohistological paramethers.
  • The frequency of positive cytological findings was compared to the location and the diameter of the cancer, pathohistological type of carcinoma, pathohistological stage of the disease, lymph node and the liver and/or peritoneal metastases and the type of surgical procedure.
  • [MeSH-major] Adenocarcinoma / surgery. Neoplasm Seeding. Neoplastic Cells, Circulating. Peritoneal Cavity / cytology. Stomach Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cytodiagnosis. Female. Gastrectomy. Humans. Lymphatic Metastasis. Male. Middle Aged. Peritoneal Lavage. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / secondary

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  • [CommentIn] Vojnosanit Pregl. 2006 Apr;63(4):347-8 [16683400.001]
  • (PMID = 16683401.001).
  • [ISSN] 0042-8450
  • [Journal-full-title] Vojnosanitetski pregled
  • [ISO-abbreviation] Vojnosanit Pregl
  • [Language] srp
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Serbia and Montenegro
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75. Zee SY, Hochwald SN, Conlon KC, Brennan MF, Klimstra DS: Pleomorphic pancreatic endocrine neoplasms: a variant commonly confused with adenocarcinoma. Am J Surg Pathol; 2005 Sep;29(9):1194-200
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  • [Title] Pleomorphic pancreatic endocrine neoplasms: a variant commonly confused with adenocarcinoma.
  • Significant nuclear pleomorphism is a feature that may raise concerns about aggressive behavior or even obscure the endocrine nature of the neoplasm.
  • Six tumors (75%) were initially misdiagnosed in 5 cases as adenocarcinoma and in one as solid-pseudopapillary tumor; in 2 cases, the misdiagnosis was based on fine needle aspiration cytology and in 4 on histologic examination.
  • Six patients underwent curative resection; at follow-up, 4 were free of disease at 11, 13, 30, 112 months (mean, 42 months), 1 developed liver metastases at 77 months and was alive with disease at 94 months, and 1 was lost to follow-up.
  • Striking nuclear pleomorphism may occur in otherwise typical PENs and commonly causes difficulties in the distinction from adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission. Middle Aged. Prognosis. Retrospective Studies

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  • (PMID = 16096409.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Teredesai A, Wöhrmann T: Metastasizing seminal vesicle adenocarcinoma in a Wistar rat. J Vet Med A Physiol Pathol Clin Med; 2005 Apr;52(3):131-4
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  • [Title] Metastasizing seminal vesicle adenocarcinoma in a Wistar rat.
  • An adenocarcinoma in the seminal vesicles of a 15-month-old male Wistar rat from a 30-month inhalation study is described.
  • The histological features of the small nodules in the pancreas and on the surface of the liver, rectum and urinary bladder resembled those of the primary tumour in the seminal vesicles.
  • Based on these criteria, the neoplasm (mass) was diagnosed as an adenocarcinoma of the seminal vesicles.
  • The immunohistological examination confirmed the diagnosis, i.e. immunostaining was positive for cytokeratins (4, 7, 14, 15, 18, and 19), vimentin, PCNA, and ED(1).
  • [MeSH-major] Adenocarcinoma / veterinary. Genital Neoplasms, Male / veterinary. Rats, Wistar. Rodent Diseases / pathology. Seminal Vesicles

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  • (PMID = 15836444.001).
  • [ISSN] 0931-184X
  • [Journal-full-title] Journal of veterinary medicine. A, Physiology, pathology, clinical medicine
  • [ISO-abbreviation] J Vet Med A Physiol Pathol Clin Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 68238-35-7 / Keratins
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77. Yasuda M, Senju T, Aratake Y, Nakamura T, Horikawa Y, Yokota M, Sumii T, Iguchi H, Funakoshi A, Nishiyama K: [A case of pancreatic ductal adenocarcinoma with rapid progress in a young man]. Nihon Shokakibyo Gakkai Zasshi; 2006 Feb;103(2):194-9
MedlinePlus Health Information. consumer health - Pancreatic Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of pancreatic ductal adenocarcinoma with rapid progress in a young man].
  • Various imaging studies showed a solid tumor (4cm in diameter) in the tail of the pancreas, multiple hypovascular tumors in liver.
  • Biopsy of hepatic tumor demonstrated that tumor cells had eosinophilic cytoplasm generally and unevenly distributed polymorphic nucleus.
  • Final diagnosis of autopsy was pancreatic ductal adenocarcinoma.
  • Pancreatic ductal adenocarcinoma in the young patients is rare, and we reported this case in addition to consideration on literature.
  • [MeSH-major] Adenocarcinoma / diagnosis. Pancreatic Ducts. Pancreatic Neoplasms / diagnosis

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  • (PMID = 16506669.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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78. Goodman ZD: Neoplasms of the liver. Mod Pathol; 2007 Feb;20 Suppl 1:S49-60
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  • [Title] Neoplasms of the liver.
  • Primary neoplasms of the liver are composed of cells that resemble the normal constituent cells of the liver.
  • Hepatocellular carcinoma, in which the tumor cells resemble hepatocytes, is the most frequent primary liver tumor, and is highly associated with chronic viral hepatitis and cirrhosis of any cause.
  • Benign tumors, such as hepatocellular adenoma in a noncirrhotic liver or a large, dysplastic nodule in a cirrhotic liver, must be distinguished from well-differentiated hepatocellular carcinoma.
  • Cholangiocarcinoma, a primary adenocarcinoma that arises from a bile duct, is second in frequency.
  • Cholangiocarcinoma resembles adenocarcinomas arising in other tissues, so a definitive diagnosis relies on the exclusion of an extrahepatic primary and distinction from benign biliary lesions.
  • [MeSH-major] Adenoma, Liver Cell / pathology. Carcinoma, Hepatocellular / pathology. Hepatocytes / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / diagnosis. Diagnosis, Differential. Female. Humans. Male

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  • (PMID = 17486052.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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79. Sentani K, Oue N, Sakamoto N, Arihiro K, Aoyagi K, Sasaki H, Yasui W: Gene expression profiling with microarray and SAGE identifies PLUNC as a marker for hepatoid adenocarcinoma of the stomach. Mod Pathol; 2008 Apr;21(4):464-75
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gene expression profiling with microarray and SAGE identifies PLUNC as a marker for hepatoid adenocarcinoma of the stomach.
  • Immunostaining for PLUNC in 140 gastric cancer cases revealed strong and extensive staining of PLUNC in hepatoid adenocarcinoma of the stomach, whereas 7% of conventional gastric cancer cases showed focal immunostaining of PLUNC.
  • Gastric hepatoid adenocarcinoma is an extrahepatic tumor characterized by morphologic similarities to hepatocellular carcinoma.
  • To investigate the utility of PLUNC immunostaining in the diagnosis of gastric hepatoid adenocarcinoma, six cases of gastric hepatoid adenocarcinoma (six primary tumors and two associated liver metastases) were studied further.
  • PLUNC staining was observed in both the hepatoid adenocarcinoma and tubular/papillary adenocarcinoma components of primary tumors, although PLUNC staining was preferentially localized in tubular/papillary adenocarcinoma components.
  • Staining of PLUNC was also detected in both liver metastases.
  • PLUNC staining was not observed in 52 cases of primary hepatocellular carcinoma or in normal adult or fetal liver.
  • These results indicate that PLUNC is a novel marker that distinguishes gastric hepatoid adenocarcinoma from primary hepatocellular carcinoma.
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / analysis. Glycoproteins / biosynthesis. Oligonucleotide Array Sequence Analysis. Phosphoproteins / biosynthesis. Stomach Neoplasms / metabolism
  • [MeSH-minor] Blotting, Western. Carcinoma, Hepatocellular / diagnosis. Carcinoma, Hepatocellular / metabolism. Diagnosis, Differential. Gene Expression. Gene Expression Profiling. Humans. Immunohistochemistry. Liver Neoplasms / diagnosis. Liver Neoplasms / metabolism. Male. Middle Aged. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 18204429.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BPIFA1 protein, human; 0 / Biomarkers, Tumor; 0 / Glycoproteins; 0 / Phosphoproteins
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80. Johnson EE, Leverson GE, Pirsch JD, Heise CP: A 30-year analysis of colorectal adenocarcinoma in transplant recipients and proposal for altered screening. J Gastrointest Surg; 2007 Mar;11(3):272-9
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  • [Title] A 30-year analysis of colorectal adenocarcinoma in transplant recipients and proposal for altered screening.
  • However, the incidence and specific risk for colorectal adenocarcinoma, although previously proposed, has been difficult to calculate.
  • We reviewed the University of Wisconsin transplant database for all cases of colorectal adenocarcinoma to assess the risk of this malignancy, as well as the need for improved screening in this population.
  • METHODS: The transplant database was queried using diagnosis codes for colorectal adenocarcinoma to configure a list of eligible patients.
  • Exclusion criteria included: age less than 18 years at the time of transplant, diagnosis of colorectal cancer or patient death less than 12 months posttransplant, and pretransplant history of colorectal cancer or proctocolectomy.
  • RESULTS: A total of 5,603 kidney, liver, or combination transplants were eligible for analysis from 1966 through 2004.
  • We identified 40 cases of colorectal adenocarcinoma.
  • Twenty-five of these cases (62%) occurred in kidney transplant recipients, 13 after liver transplant, and two after kidney-pancreas combination.
  • The median survival postcancer diagnosis was 2.3 years.
  • The 5-year survival postcancer diagnosis is 63.5% in the general population (SEER), vs. 30.7% in the transplant cohort.
  • The SEER median age at diagnosis of colorectal adenocarcinoma is 72.0 years.
  • Of the transplant recipients who developed cancer, the median age at diagnosis was 58.7 years (32.4 to 78.2), and 11 patients (27%) were diagnosed at or before age 50.
  • In the U.S. population, the annual incidence of colorectal adenocarcinoma below the age of 50 is 0.0055% (5.52/100,000) and the 10-year extrapolated incidence is 0.11%.
  • In this under-50 cohort, median time from transplant to cancer diagnosis was 7.8 years.
  • CONCLUSION: The incidence of and 5-year survival after diagnosis of colorectal adenocarcinoma in transplant recipients is markedly different than the general population.
  • [MeSH-major] Adenocarcinoma / etiology. Colorectal Neoplasms / etiology. Organ Transplantation / adverse effects
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Incidence. Kidney Transplantation / adverse effects. Liver Transplantation / adverse effects. Male. Middle Aged. Pancreas Transplantation / adverse effects. Risk Factors. Survival Rate. United States / epidemiology

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  • (PMID = 17458597.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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81. Sasaki K, Natsugoe S, Aridome K, Ishigami S, Hokita S, Aikou T: The successfully curative treatment of advanced gastric adenocarcinoma with multiple liver metastases and paraaortic lymph node metastases by salvage operation following the biweekly paclitaxel and S-1 combination chemotherapy: a case report. Hepatogastroenterology; 2007 Dec;54(80):2421-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The successfully curative treatment of advanced gastric adenocarcinoma with multiple liver metastases and paraaortic lymph node metastases by salvage operation following the biweekly paclitaxel and S-1 combination chemotherapy: a case report.
  • We report the case of 67-year-old man who was given a diagnosis of advanced gastric adenocarcinoma.
  • Complete response of multiple liver and paraaortic lymph node metastases occurred in this patient after combination chemotherapy with systemic injection of paclitaxel and oral administration of novel dihydropyrimidine- dehydrogenase- inhibitory fluoropyrimidine (S-1).
  • According to the operative findings, the tumor was curatively removed along with the liver metastases and paraaortic lymph node metastases.
  • Biopsy of the liver was performed and the pathological diagnosis indicated no gastric adenocarcinoma cells.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / secondary. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Liver Neoplasms / secondary. Salvage Therapy. Stomach Neoplasms / drug therapy. Stomach Neoplasms / pathology

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  • (PMID = 18265679.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; P88XT4IS4D / Paclitaxel
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82. Fadare O, Parkash V, Fiedler PN, Mayerson AB, Asiyanbola B: Tumor-to-tumor metastasis to a thyroid follicular adenoma as the initial presentation of a colonic adenocarcinoma. Pathol Int; 2005 Sep;55(9):574-9
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  • [Title] Tumor-to-tumor metastasis to a thyroid follicular adenoma as the initial presentation of a colonic adenocarcinoma.
  • Herein is described the case of a 59-year-old woman whose thyroid nodule (a follicular adenoma) was resected and found to contain foci of a well-differentiated adenocarcinoma with a morphologic and immunohistochemical profile consistent with origination from the lower gastrointestinal tract.
  • Subsequent diagnostic work-up revealed a sigmoid colon tumor with metastases to the liver.
  • This is, to the authors' knowledge, the first reported example of a colon adenocarcinoma whose initial clinical manifestation was a metastasis to a thyroid neoplasm and only the third reported example of a colonic adenocarcinoma metastatic to a thyroid tumor.
  • In a review of previously reported examples of tumor-to-tumor metastases involving a thyroid neoplasm as the recipient, the following features were present in the majority: (i) multifocality of the metastatic tumor aggregates;.
  • In general, strikingly divergent morphologic features in an otherwise typical thyroid neoplasm should elicit a differential diagnosis that takes into consideration the possibility of metastasis.
  • [MeSH-major] Adenocarcinoma / secondary. Adenoma / pathology. Colonic Neoplasms / pathology. Thyroid Neoplasms / secondary
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Biomarkers, Tumor / metabolism. Female. Humans. Immunohistochemistry. Liver Neoplasms / metabolism. Liver Neoplasms / secondary. Middle Aged. Neoplasm Staging. Neoplasms, Multiple Primary. Treatment Outcome

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  • (PMID = 16143033.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor
  • [Number-of-references] 23
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83. Kalteis T, Heers G, Elsner R: Adenocarcinoma of the rectum in childhood following chemotherapy and radiotherapy for a rhabdomyosarcoma--a case report. Eur J Pediatr Surg; 2005 Jun;15(3):210-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma of the rectum in childhood following chemotherapy and radiotherapy for a rhabdomyosarcoma--a case report.
  • We report a case of rectal adenocarcinoma in a 9-year-old boy, which took the form of a second malignant neoplasm following treatment for an early childhood malignancy.
  • At the time of diagnosis of the rectal carcinoma, the tumor had already progressed to the stage of metastatic disease.
  • Therapy consisted of deep anterior rectal resection and regional arterial chemotherapy for liver metastases.
  • The child died 18 months after the diagnosis of rectal carcinoma.
  • As survival for childhood tumors improves, rare second malignant neoplasms will become increasingly common in children and adolescents.
  • The increased risk of second malignant neoplasms and an early onset of adult-type tumors has to be considered.
  • [MeSH-major] Adenocarcinoma / surgery. Neoplasms, Second Primary. Rectal Neoplasms / surgery. Rhabdomyosarcoma, Embryonal / drug therapy. Rhabdomyosarcoma, Embryonal / radiotherapy
  • [MeSH-minor] Child. Fatal Outcome. Humans. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Male. Thigh

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  • (PMID = 15999318.001).
  • [ISSN] 0939-7248
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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84. Goto H, Tanaka A, Kondo F, Takeshita K, Nagashima I, Hanawa N, Aiso M, Takamori Y, Kato K, Takahashi Y, Fukushima J, Furui S, Fukusato T, Asano T, Takikawa H: Carcinosarcoma of the liver. Intern Med; 2010;49(23):2577-82
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  • [Title] Carcinosarcoma of the liver.
  • Herein we present a 73-year-old man with primary carcinosarcoma of the liver, a rare malignant tumor of the liver.
  • The case was followed up due to HBV-related liver cirrhosis.
  • Regular check-up by ultrasound demonstrated a hyperechoic tumor in the left lobe of the liver, and he was referred and admitted to our hospital.
  • Dynamic CT studies revealed a mostly hypoenhancing hepatic mass with a peripheral ring enhancement.
  • Tumor tissue with adenocarcinoma, osteosarcoma and chondrosarcoma were also detected.
  • Immunohistochemical studies demonstrated that tumor cells were HepPar 1 positive in hepatocellular carcinoma, and CK19 and partly CK7 positive in adenocarcinoma.
  • The diagnosis of carcinosarcoma was made based on the concomitant presence of HCC and sarcomatous components, yet it is noteworthy that various types of tumor cells were observed.
  • [MeSH-major] Carcinosarcoma / diagnosis. Carcinosarcoma / surgery. Liver Neoplasms / diagnosis. Liver Neoplasms / surgery

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  • (PMID = 21139295.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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85. Enestvedt CK, Mayo SC, Diggs BS, Mori M, Austin DA, Shipley DK, Sheppard BC, Billingsley KG: Diagnostic laparoscopy for patients with potentially resectable pancreatic adenocarcinoma: is it cost-effective in the current era? J Gastrointest Surg; 2008 Jul;12(7):1177-84
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  • [Title] Diagnostic laparoscopy for patients with potentially resectable pancreatic adenocarcinoma: is it cost-effective in the current era?
  • INTRODUCTION: For patients with potentially resectable pancreatic cancer, diagnostic laparoscopy may identify liver and peritoneal metastases that are difficult to detect with other staging modalities.
  • De-identified patient records were reviewed to determine the role and findings of laparoscopic exploration.
  • CONCLUSION: Cost analysis indicates that the case-specific or routine use of laparoscopy in pancreatic cancer does not add significantly to the overall expense of treatment and supports the use of laparoscopy in patients with known or suspected pancreatic adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Laparoscopy / economics. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cost-Benefit Analysis. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging / economics. Neoplasm Staging / methods. Oregon. Pancreatectomy. Preoperative Care / economics. Preoperative Care / methods. Prognosis. Retrospective Studies

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  • (PMID = 18470572.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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86. Kawakami H, Kuwatani M, Fujiya Y, Uebayashi M, Konishi K, Makiyama H, Hashino S, Kubota K, Itoh T, Asaka M: [A case of granulocyte-colony stimulating factor producing ductal adenocarcinoma of the pancreas]. Nihon Shokakibyo Gakkai Zasshi; 2007 Feb;104(2):233-8
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  • [Title] [A case of granulocyte-colony stimulating factor producing ductal adenocarcinoma of the pancreas].
  • We report a case of pancreatic ductal adenocarcinoma producing granulocyte-colony stimulating factor (G-CSF).
  • An abdominal CT scan revealed masses in the pancreatic body to the tail, and both lobes of the liver.
  • A biopsy specimen of the hepatic tumor demonstrated metastatic poorly differentiated adenocarcinoma.
  • The diagnosis of autopsy was pancreatic ductal adenocarcinoma.
  • The final diagnosis was G-CSF-producing pancreatic carcinoma.
  • [MeSH-major] Adenocarcinoma / metabolism. Carcinoma, Pancreatic Ductal / metabolism. Granulocyte Colony-Stimulating Factor / biosynthesis. Pancreatic Neoplasms / metabolism

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  • (PMID = 17283419.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Interleukin-6; 143011-72-7 / Granulocyte Colony-Stimulating Factor
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87. Ellsmere J, Mortele K, Sahani D, Maher M, Cantisani V, Wells W, Brooks D, Rattner D: Does multidetector-row CT eliminate the role of diagnostic laparoscopy in assessing the resectability of pancreatic head adenocarcinoma? Surg Endosc; 2005 Mar;19(3):369-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Does multidetector-row CT eliminate the role of diagnostic laparoscopy in assessing the resectability of pancreatic head adenocarcinoma?
  • BACKGROUND: We hypothesized that the high-quality images from multidetector-row computed tomography (MDCT) would lead to improved sensitivity and specificity for predicting resectable pancreatic head adenocarcinoma, thus diminishing the value of staging laparoscopy.
  • The 21 unresectable cases, included five liver metastases, three peritoneal metastases, and 13 locally invasive tumors.
  • CONCLUSIONS: Despite the improvements in image quality obtained with multidetector-row technology, CT imaging remains a relatively nonspecific test for predicting resectability in patients with adenocarcinoma of the head of the pancreas.
  • Minimally invasive modalities with higher specificity, particularly laparoscopy, continue to have an important role in staging pancreatic head adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Laparoscopy. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / surgery. Tomography, X-Ray Computed

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  • (PMID = 15624058.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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88. Sasaki S, Hatanaka K, Sahara N, Uekusa T, Hirayama K, Shirahata A, Ishimaru M: Collision tumor of primary malignant lymphoma and adenocarcinoma in the colon: report of a case. Surg Today; 2010 Oct;40(10):975-81
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  • [Title] Collision tumor of primary malignant lymphoma and adenocarcinoma in the colon: report of a case.
  • This report presents the case of a 62-year-old man with a collision tumor of primary malignant lymphoma and adenocarcinoma in the cecum.
  • Malignant lymphoma was also seen in the duodenum.
  • Systemic chemotherapy was administered for the malignant lymphoma, and a complete response was thus obtained.
  • However, just after chemotherapy multiple liver metastases of adenocarcinoma emerged, and chemotherapy against adenocarcinoma was therefore continued.
  • The occurrence of synchronous lymphoma and adenocarcinoma of the colorectum is rare.
  • [MeSH-major] Adenocarcinoma / diagnosis. Cecal Neoplasms / diagnosis. Duodenal Neoplasms / diagnosis. Lymphoma, B-Cell / diagnosis. Lymphoma, Follicular / diagnosis. Neoplasms, Multiple Primary / diagnosis
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Biopsy, Needle. Colectomy / methods. Colonoscopy. Humans. Male. Middle Aged. Neoplasm Staging. Tomography, X-Ray Computed

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  • (PMID = 20872204.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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89. Van Kerkhóve F, Coenegrachts K, Steyaert L, Van Den Berghe I, Casselman JW: Collision tumor in the ileum: a rare combination of an adenocarcinoma and small cell neuroendocrine tumor. JBR-BTR; 2006 Sep-Oct;89(5):258-60
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  • [Title] Collision tumor in the ileum: a rare combination of an adenocarcinoma and small cell neuroendocrine tumor.
  • Ultrasound examination discovered an inhomogeneous vascularised mass originating from a small bowel loop, mesenteric enlarged lymph nodes and a nodule in the liver.
  • Pathology revealed a rare ileal collision tumor consisting of an adenocarcinoma and a small cell neuroendocrine tumor with peritoneal metastasis of neuroendocrine origin and coincidental benign lesions on both ovaries.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma, Villous / diagnosis. Adenomatous Polyps / diagnosis. Carcinoma, Small Cell / diagnosis. Ileal Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Tomography, X-Ray Computed. Ultrasonography
  • [MeSH-minor] Adenofibroma / diagnosis. Adenofibroma / pathology. Adenofibroma / surgery. Aged. Cystadenoma / diagnosis. Cystadenoma / pathology. Cystadenoma / surgery. Female. Fibroma / diagnosis. Fibroma / pathology. Fibroma / surgery. Humans. Ileum / pathology. Ileum / surgery. Intestinal Mucosa / pathology. Intestinal Mucosa / surgery. Liver / pathology. Liver / surgery. Lymphatic Metastasis / pathology. Mesentery / pathology. Mesentery / surgery. Omentum / pathology. Omentum / surgery. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / pathology. Ovarian Neoplasms / surgery. Ovariectomy. Ovary / pathology. Peritoneum / pathology. Peritoneum / surgery

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  • (PMID = 17147014.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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90. Ye XP, Li LQ, Peng T, Xiao KY, Su ZX, Shang LM, Su M, Xu BH: [Diagnosis and treatment of primary clear cell carcinoma of the liver]. Zhonghua Zhong Liu Za Zhi; 2010 Jan;32(1):64-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnosis and treatment of primary clear cell carcinoma of the liver].
  • OBJECTIVE: To investigate the clinicopathological features, diagnosis, treatment and prognosis of primary clear cell carcinoma of the liver (PCCCL).
  • Liver cirrhosis was found in 75.0% of the patients.
  • CONCLUSION: The clinical characteristics of primary clear cell carcinoma of the liver are similar to that of common hepatocellular carcinoma.
  • It is difficult to be diagnosed preoperatively and final diagnosis depends on pathological examination.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Adenocarcinoma, Clear Cell / surgery. Hepatectomy. Liver Neoplasms / pathology. Liver Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Hepatitis B. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Survival Rate. alpha-Fetoproteins / analysis

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  • (PMID = 20211073.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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91. Kondo N, Shiono Y, Yoshino Y, Sugaya S, Abe M, Koshitaka Y: [Papillary adenocarcinoma in a seminal vesicle cyst associated with contralateral renal agenesis: a case report]. Hinyokika Kiyo; 2007 Mar;53(3):175-8
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  • [Title] [Papillary adenocarcinoma in a seminal vesicle cyst associated with contralateral renal agenesis: a case report].
  • We report a case of papillary adenocarcinoma inside a seminal vesicle cyst associated with contralateral renal agenesis in a 30-year-old man.
  • Surgical excision was performed but he died due to liver metastases one year later.
  • [MeSH-major] Adenocarcinoma, Papillary / diagnosis. Cysts / diagnosis. Genital Neoplasms, Male / diagnosis. Kidney / abnormalities. Seminal Vesicles

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  • (PMID = 17447487.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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92. Jang JS, Yim HJ, Lee BJ, Kim SY, Kim DI, Lee HS, Lee SW, Choi JH: [A case of hepatic metastasis of small cell carcinoma from mixed small cell carcinoma and adenocarcinoma of the stomach]. Korean J Gastroenterol; 2007 Sep;50(3):193-8
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  • [Title] [A case of hepatic metastasis of small cell carcinoma from mixed small cell carcinoma and adenocarcinoma of the stomach].
  • We report a 71-year-old man with upper abdominal pain diagnosed as single hepatic metastasis of SCC from mixed SCC and adenocarcinoma of the stomach.
  • An abdominal CT scan revealed a huge dumbbell shaped mass with peripheral arterial enhancement and central low density in left lobe of the liver.
  • On the basis of these findings, we made a final diagnosis of mixed SCC and adenocarcinoma of the stomach.
  • In addition, we also confirmed hepatic metastasis of SCC through the microscopic finding and immunostaining of tissues of liver mass.
  • Conclusively, we report a case of hepatic metastasis of SCC only from mixed SCC adenocarcinoma of the stomach.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Small Cell / diagnosis. Carcinoma, Small Cell / secondary. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Stomach Neoplasms / diagnosis

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  • (PMID = 17885286.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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93. Shimizu T, Tajiri T, Akimaru K, Arima Y, Yoshida H, Yokomuro S, Mamada Y, Taniai N, Mizuguchi Y, Kawahigashi Y, Naito Z: Combined neuroendocrine cell carcinoma and adenocarcinoma of the gallbladder: report of a case. J Nippon Med Sch; 2006 Apr;73(2):101-5
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  • [Title] Combined neuroendocrine cell carcinoma and adenocarcinoma of the gallbladder: report of a case.
  • Abdominal computed tomography confirmed thickening of the gallbladder wall and a 15 x 8 cm mass occupying almost all of the right lobe and medial segment of the liver.
  • With a preoperative diagnosis of malignant gallbladder tumor infiltrating the liver, right hepatic trisegmentectomy was performed.
  • Near this small cell proliferation was a focus of tubular adenocarcinoma that showed a zone of transition from the small cell neuroendocrine pattern.
  • The patient was diagnosed with neuroendocrine cell carcinoma combined with adenocarcinoma of the gallbladder.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Neuroendocrine / pathology. Gallbladder Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 16641536.001).
  • [ISSN] 1345-4676
  • [Journal-full-title] Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
  • [ISO-abbreviation] J Nippon Med Sch
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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94. Braun U, Grest P, Jehle W, Kaps S, Spiess B: [Intraocular hemorrhage in a goat with thrombocytopenia and metastasis of an adenocarcinoma in the iris]. Schweiz Arch Tierheilkd; 2008 Jul;150(7):359-62
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  • [Title] [Intraocular hemorrhage in a goat with thrombocytopenia and metastasis of an adenocarcinoma in the iris].
  • This case report describes the findings in a 10-year-old goat with metastasis of an adenocarcinoma in the iris.
  • There were neoplastic alterations in the iris, the oesophagus, the lung lobes, the liver, the kidney and in the prescapular, retropharyngeal, mediastinal and hepatic lymph nodes.
  • Histologically, a diagnosis of carcinoma was confirmed, but the origin of the tumour could not be determined.
  • [MeSH-major] Adenocarcinoma / veterinary. Eye Hemorrhage / veterinary. Goat Diseases / diagnosis. Iris Neoplasms / veterinary

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  • (PMID = 18714940.001).
  • [ISSN] 0036-7281
  • [Journal-full-title] Schweizer Archiv für Tierheilkunde
  • [ISO-abbreviation] Schweiz. Arch. Tierheilkd.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Switzerland
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95. Vlachostergios PJ, Voutsadakis IA, Barbanis S, Karasavvidou F, Papandreou CN: AFP-producing hepatoid adenocarcinoma of the stomach: a case report. Cases J; 2009;2:9296
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  • [Title] AFP-producing hepatoid adenocarcinoma of the stomach: a case report.
  • Hepatoid gastric adenocarcinoma is a distinct variant of gastric carcinoma which represents a comparatively small percentage of the disease and in many cases is producing high serum alpha-fetoprotein (AFP).
  • We report a case of an 85 year old woman who presented with epigastric and right upper quadrant pain and was found in a CT scan to have multiple liver nodules and a gastric antrum mass as well as an elevated AFP level of 155000 IU/ml.
  • An endoscopic biopsy of the antral mass showed hepatoid variant of gastric adenocarcinoma.
  • The patient refused any further treatment and died 4 months after diagnosis.
  • Hepatoid gastric adenocarcinoma is considered to have a poor prognosis, although cases with survival of several years have been reported.
  • Poor outcome in most of the cases is due to the fact that, as in our patient, metastatic disease is already present at diagnosis.

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  • (PMID = 20062620.001).
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96. Reid BJ, Li X, Galipeau PC, Vaughan TL: Barrett's oesophagus and oesophageal adenocarcinoma: time for a new synthesis. Nat Rev Cancer; 2010 Feb;10(2):87-101
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Barrett's oesophagus and oesophageal adenocarcinoma: time for a new synthesis.
  • The public health importance of Barrett's oesophagus lies in its association with oesophageal adenocarcinoma.
  • The incidence of oesophageal adenocarcinoma has risen at an alarming rate over the past four decades in many regions of the Western world, and there are indications that the incidence of this disease is on the rise in Asian populations in which it has been rare.
  • Much has been learned of host and environmental risk factors that affect the incidence of oesophageal adenocarcinoma, and data indicate that patients with Barrett's oesophagus rarely develop oesophageal adenocarcinoma.
  • Given that 95% of oesophageal adenocarcinomas arise in individuals without a prior diagnosis of Barrett's oesophagus, what strategies can be used to reduce late diagnosis of oesophageal adenocarcinoma?

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  • (PMID = 20094044.001).
  • [ISSN] 1474-1768
  • [Journal-full-title] Nature reviews. Cancer
  • [ISO-abbreviation] Nat. Rev. Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA124911-02; United States / NCI NIH HHS / CA / K05 CA124911; United States / NCI NIH HHS / CA / P01 CA091955; United States / NCI NIH HHS / CA / P01 CA091955-08; United States / NCI NIH HHS / CA / K05 CA124911-02
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 218
  • [Other-IDs] NLM/ NIHMS200752; NLM/ PMC2879265
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97. Segawa N, Inamoto T, Ibuki N, Mizutani Y, Azuma H, Tsuji M, Katsuoka Y: [Neuroendocrine differentiation in adenocarcinoma of the prostate during hormonal treatment : a case report]. Hinyokika Kiyo; 2010 Jan;56(1):49-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Neuroendocrine differentiation in adenocarcinoma of the prostate during hormonal treatment : a case report].
  • A case of neuroendocrine (NE) differentiated prostate cancer is reported herein, which was progressed with NE differentiation during hormonal treatment in adenocarcinoma of the prostate.
  • A prostate biopsy was performed and histological examinations indicated poorly differentiated adenocarcinoma with a Gleason score of 5 + 4 = 9.
  • However, he had liver metastases 3 months later.
  • His condition worsened rapidly and he died at 8 months after definite diagnosis.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / pathology. Antineoplastic Agents, Hormonal / therapeutic use. Leuprolide / therapeutic use. Prostatic Neoplasms / drug therapy. Prostatic Neoplasms / pathology

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  • (PMID = 20104011.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; EC 3.4.21.77 / Prostate-Specific Antigen; EC 4.2.1.11 / Phosphopyruvate Hydratase; EFY6W0M8TG / Leuprolide
  • [Number-of-references] 26
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98. Kitley CA, Mosier AD, Keylock J, Nguyen D: Malignant priapism secondary to adenocarcinoma of the prostate. BMJ Case Rep; 2010;2010
MedlinePlus Health Information. consumer health - Prostate Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant priapism secondary to adenocarcinoma of the prostate.
  • [MeSH-major] Adenocarcinoma / diagnosis. Penile Neoplasms / secondary. Priapism / etiology. Prostatic Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biopsy, Large-Core Needle. Bone Neoplasms / diagnosis. Bone Neoplasms / secondary. Diagnosis, Differential. Disease Progression. Fatal Outcome. Follow-Up Studies. Humans. Image Interpretation, Computer-Assisted. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Lymphatic Metastasis / pathology. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness. Palliative Care. Penis / pathology. Prostate / pathology. Tomography, X-Ray Computed. Urinary Bladder / pathology

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  • (PMID = 22789733.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3028547
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99. Dennis RJ, Alberts JC: The implications of an incidental chronic lymphocytic leukaemia in a resection specimen for colorectal adenocarcinoma. World J Surg Oncol; 2007;5:126

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The implications of an incidental chronic lymphocytic leukaemia in a resection specimen for colorectal adenocarcinoma.
  • We report an unusual case of a presumed B cell CLL diagnosed on the basis of histological analysis of lymph nodes recovered from a resection specimen for rectal adenocarcinoma.
  • We considered aetiological factors which may have linked the synchronous diagnosis of the two malignancies and the potential implications for the natural history of the two malignancies on one another.
  • CASE PRESENTATION: A 70-year-old male underwent low anterior resection with total mesorectal excision for a rectal adenocarcinoma.
  • Full blood count, urea and electrolytes and liver function tests were all within normal limits.
  • As well as confirming a pT3 N1 adenocarcinoma, histological analysis showed lymph nodes with an infiltrate of small lymphoid cells.
  • Examples such as our case of synchronous diagnosis of two malignancies in a patient are likely to increase with the aging population.
  • In our case, we considered that slow progression of the B cell CLL may increase the risk of recurrent rectal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Leukemia, Lymphocytic, Chronic, B-Cell / pathology. Neoplasms, Second Primary / pathology. Neoplasms, Second Primary / surgery. Rectal Neoplasms / pathology

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  • (PMID = 17971235.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2169241
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100. Matsuda M, Amemiya H, Kono H, Suzuki T, Chang MS, Izawa S, Furuya S, Takano A, Matsumoto Y, Fujii H: A huge primary peritoneal papillary adenocarcinoma which demonstrated imaging findings similar to those of extrahepatic-growing type hepatic tumor: report of a case. Surg Today; 2005;35(2):175-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A huge primary peritoneal papillary adenocarcinoma which demonstrated imaging findings similar to those of extrahepatic-growing type hepatic tumor: report of a case.
  • We herein report a 69-year-old woman who presented with a huge intra-abdominal tumor which demonstrated imaging findings similar to those of extrahepatic-growing type hepatic tumor, but turned out to be primary peritoneal papillary adenocarcinoma.
  • Computed tomography showed a well-demarcated mass, measuring 12.0 cm in diameter, which came in contact with the lateral segment of the liver and invaded the diaphragm and abdominal wall.
  • A fine-needle aspiration biopsy of the tumor showed poorly differentiated adenocarcinoma of unknown origin.
  • The patient then underwent a tumorectomy together with a lateral segmentectomy of the liver, a splenectomy, a partial resection of the diaphragm and abdominal wall, and a left oophorectomy.
  • Histological and immunohistochemical examinations demonstrated the tumor to be primary peritoneal papillary adenocarcinoma.
  • [MeSH-major] Adenocarcinoma, Papillary / radiography. Liver Neoplasms / radiography. Peritoneal Neoplasms / radiography
  • [MeSH-minor] Aged. Antineoplastic Agents / therapeutic use. Cisplatin / therapeutic use. Diagnosis, Differential. Female. Fluorouracil / therapeutic use. Humans. Tomography, X-Ray Computed

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  • (PMID = 15674505.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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