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Items 1 to 76 of about 76
1. Joo HJ, Kim GH, Jeon WJ, Chae HB, Park SM, Youn SJ, Choi JW, Sung R: Metachronous bile duct cancer nine years after resection of gallbladder cancer. World J Gastroenterol; 2009 Jul 21;15(27):3440-4
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  • [Title] Metachronous bile duct cancer nine years after resection of gallbladder cancer.
  • We report a rare case of a 74-year-old man with metachronous gallbladder cancer and bile duct cancer who underwent curative resection twice, with the operations nine years apart.
  • This was a well-differentiated adenocarcinoma, with negative resection margins (T2N0M0, stage IB).
  • Nine years later, during a follow-up examination, abdominal computed tomography and MRCP showed an enhanced 1.7 cm mass in the hilum that extended to the second branch of the right intrahepatic bile duct.
  • We diagnosed this lesion as a perihilar bile duct cancer, Bismuth type IIIa, and performed bile duct excision, right hepatic lobectomy and Roux-en-Y hepaticojejunostomy.
  • The histological diagnosis was a well-differentiated adenocarcinoma with one regional lymph node metastasis (T1N1M0, stage IIB).
  • [MeSH-major] Adenocarcinoma / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Gallbladder Neoplasms / pathology. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Treatment Outcome. Young Adult

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  • (PMID = 19610150.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2712910
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2. Luke C, Price T, Roder D: Epidemiology of cancer of the liver and intrahepatic bile ducts in an Australian population. Asian Pac J Cancer Prev; 2010;11(6):1479-85
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  • [Title] Epidemiology of cancer of the liver and intrahepatic bile ducts in an Australian population.
  • The incidence of liver and intrahepatic bile duct cancer in Australia is low at about one third the world average but increases are evident.
  • Survival increases may be due to earlier diagnosis from alpha feta protein testing and diagnostic imaging, plus more aggressive treatment of localized disease.
  • [MeSH-major] Adenocarcinoma / epidemiology. Bile Duct Neoplasms / epidemiology. Carcinoma, Hepatocellular / epidemiology. Cholangiocarcinoma / epidemiology. Liver Neoplasms / epidemiology
  • [MeSH-minor] Aged. Aged, 80 and over. Australia / epidemiology. Bile Ducts, Intrahepatic. Female. Humans. Male. Middle Aged. Survival Rate. Treatment Outcome

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  • (PMID = 21338184.001).
  • [ISSN] 2476-762X
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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3. Chaudhary HB, Bhanot P, Logroño R: Phenotypic diversity of intrahepatic and extrahepatic cholangiocarcinoma on aspiration cytology and core needle biopsy: case series and review of the literature. Cancer; 2005 Aug 25;105(4):220-8
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  • [Title] Phenotypic diversity of intrahepatic and extrahepatic cholangiocarcinoma on aspiration cytology and core needle biopsy: case series and review of the literature.
  • BACKGROUND: Cholangiocarcinoma (CC) represents approximately 10% of primary liver malignancies and can mimic metastatic adenocarcinoma.
  • METHODS: The authors retrospectively reviewed the cytopathology files at the University of Texas Medical Branch to identify patients who were diagnosed with intrahepatic or extrahepatic CC by aspiration cytology between 1995 and 2004.
  • The phenotypic distribution of CC according to the World Health Organization (WHO) histologic classification was 9 adenocarcinoma (intrahepatic), not otherwise specified (NOS) (69%); 2 gastric foveolar type (extrahepatic) CCs (15%); 1 intestinal type (extrahepatic) CC (8%); and 1 sarcomatous/spindle cell type (intrahepatic) CC (8%).
  • One adenocarcinoma, NOS was well differentiated CC with bland tubular architecture, and one was pleomorphic.
  • CONCLUSIONS: Classification of intrahepatic and extrahepatic CC in aspiration cytology specimens was achieved in a reliable manner concordant with the WHO histologic classification.
  • The addition of core biopsy and/or ancillary studies, such as histochemical and immunochemical stains, were helpful in reaching the correct diagnosis.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts, Extrahepatic / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Phenotype. Retrospective Studies

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  • [Copyright] Copyright (c) 2005 American Cancer Society.
  • (PMID = 15952192.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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4. Cereda S, Passoni P, Reni M, Viganò MG, Aldrighetti L, Nicoletti R, Villa E: The cisplatin, epirubicin, 5-fluorouracil, gemcitabine (PEFG) regimen in advanced biliary tract adenocarcinoma. Cancer; 2010 May 1;116(9):2208-14
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  • [Title] The cisplatin, epirubicin, 5-fluorouracil, gemcitabine (PEFG) regimen in advanced biliary tract adenocarcinoma.
  • BACKGROUND: Biliary tract adenocarcinoma (BTA) is an uncommon tumor with a poor prognosis and no standard, systemic chemotherapy.
  • METHODS: PEFG (cisplatin 40 mg/m(2) and epirubicin 40 mg/m(2) on Day 1; gemcitabine 600 mg/m(2) on Days 1 and 8; and 5-fluorouracil [FU] 200 mg/m(2) daily as a continuous infusion) was administered to chemotherapy-naive patients who had a cytologic or histologic diagnosis of locally advanced or metastatic BTA, aged <or=75 years, and a performance status (PS) >60 either until they had evidence progressive disease or for a maximum of 6 months.
  • Primary tumor sites were the intrahepatic bile duct in 10 patients (27%), the extrahepatic bile duct in 8 patients (22%), the gallbladder in 12 patients (32%), and the ampulla of Vater in 7 patients (19%).
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biliary Tract Neoplasms / drug therapy

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  • [Copyright] (c) 2010 American Cancer Society.
  • (PMID = 20187098.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; 3Z8479ZZ5X / Epirubicin; B76N6SBZ8R / gemcitabine; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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5. Bahra M, Langrehr JM, Neuhaus P: [Carcinomas of the distal bile duct]. Chirurg; 2006 Apr;77(4):335-40
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  • [Title] [Carcinomas of the distal bile duct].
  • Malignancies of the biliary tree are classified into three groups according to location: intrahepatic, central (perihilar), and distal.
  • Of all cholangiocarcinomas, 25% are located distally and can be subdivided into middle and lower bile duct carcinomas.
  • Intrahepatic and central cancers usually must be treated by liver surgery, whereas the majority of distal cholangiocarcinomas require pancreaticoduodenectomy.
  • In case of a small, middle bile duct carcinoma, exclusive extrahepatic bile duct resection without pancreatic resection can be adequate.
  • Cancer of the distal bile duct has to be distinguished from ductal adenocarcinoma of the pancreas and carcinoma of the ampulla of Vater.
  • [MeSH-major] Bile Duct Neoplasms / surgery. Bile Ducts, Extrahepatic / surgery. Carcinoma, Pancreatic Ductal / surgery. Cholangiocarcinoma / surgery
  • [MeSH-minor] Ampulla of Vater / pathology. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / diagnosis. Common Bile Duct Neoplasms / mortality. Common Bile Duct Neoplasms / pathology. Common Bile Duct Neoplasms / surgery. Humans. Lymph Node Excision / methods. Neoplasm Invasiveness. Neoplasm Staging. Pancreaticoduodenectomy / methods. Prognosis. Survival Rate

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  • (PMID = 16523255.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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6. Slattery JM, Sahani DV: What is the current state-of-the-art imaging for detection and staging of cholangiocarcinoma? Oncologist; 2006 Sep;11(8):913-22
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  • Cholangiocarcinoma is an adenocarcinoma that arises from the bile duct epithelium and is the second most common primary hepatobiliary cancer, after hepatocellular cancer, with approximately 2,500 cases annually in the U.S.
  • The median survival time for patients with intrahepatic cholangiocarcinoma without involvement of the hilum varies among centers from 18-30 months.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic. Cholangiocarcinoma / diagnosis

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  • (PMID = 16951395.001).
  • [ISSN] 1083-7159
  • [Journal-full-title] The oncologist
  • [ISO-abbreviation] Oncologist
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 56
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7. Kinjo N, Shimada M, Maeda T, Tanaka S, Shirabe K, Maehara Y: Preoperatively undiagnosable intrahepatic bile duct dilatation contains early-stage intrahepatic cholangiocarcinoma. Hepatogastroenterology; 2005 Sep-Oct;52(65):1368-71
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  • [Title] Preoperatively undiagnosable intrahepatic bile duct dilatation contains early-stage intrahepatic cholangiocarcinoma.
  • Intrahepatic bile duct dilatation is a clue to indicating the presence of IHCC.
  • Preoperative imaging studies of these three cases showed the dilatation and stenosis of the intrahepatic bile duct without any apparent mass.
  • As IHCC could not be ruled out, a hepatectomy was done for the purpose of both diagnosis and treatment of the patients.
  • In the case of intrahepatic bile duct dilatation and stenosis, which makes it hard to identify IHCC, surgical resection is crucial to make a definite diagnosis and prescribe the most effective course of treatment.
  • [MeSH-major] Bile Duct Neoplasms / complications. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / complications
  • [MeSH-minor] Abdominal Pain / etiology. Adenocarcinoma / pathology. Cholangiopancreatography, Endoscopic Retrograde. Dilatation, Pathologic. Humans. Liver Neoplasms / pathology. Male. Middle Aged

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  • (PMID = 16201076.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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8. Byun JH: [Radiological staging of hilar cholangiocarcinoma]. Korean J Gastroenterol; 2005 Jul;46(1):7-15
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  • Hilar cholangiocarcinoma is an adenocarcinoma arising from the bile duct epithelium, at the confluence of the right and left intrahepatic bile ducts, within the porta hepatis.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic. Cholangiocarcinoma / diagnosis

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  • (PMID = 16030398.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Journal Article; Review
  • [Publication-country] Korea (South)
  • [Number-of-references] 22
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9. Takasawa O, Kobayashi G, Noda Y, Ito K, Horaguchi J, Fujita N, Kobari M: [A case of superficial bile duct carcinoma showing extensive intraductal spread without bile duct stenosis, diagnosed by intraductal ultrasonography]. Nihon Shokakibyo Gakkai Zasshi; 2007 Feb;104(2):226-32
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  • [Title] [A case of superficial bile duct carcinoma showing extensive intraductal spread without bile duct stenosis, diagnosed by intraductal ultrasonography].
  • We report a case of superficial bile duct carcinoma showing extensive intraductal spread without dilatation of the bile duct in which diagnosis was established preoperatively by transpapillary forceps biopsy and intraductal ultrasonography.
  • A 78-year-old man was given a diagnosis of acute cholecystitis, and percutaneous transhepatic gallbladder drainage (PTGBD) was performed.
  • Cholangiography via the PTGBD tube revealed a tiny irregularity in the hilar bile duct.
  • Transpapillary intraductal ultrasonography showed that this irregularity extended from the intrahepatic bile duct to the middle of the bile duct.
  • Bile duct biopsy revealed malignancy, and thus bile duct resection and hepaticojejunostomy were performed.
  • Histological examination verified a well-differentiated adenocarcinoma confined to the epithelium and the fibromuscular layer.
  • [MeSH-major] Adenocarcinoma / ultrasonography. Bile Duct Neoplasms / ultrasonography. Bile Ducts / ultrasonography
  • [MeSH-minor] Acute Disease. Aged. Biopsy. Cholecystitis / diagnosis. Drainage. Gallbladder / surgery. Hepatectomy. Humans. Jejunostomy. Male

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  • (PMID = 17283418.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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10. Tsuyuguchi T, Sakai Y, Sugiyama H, Miyakawa K, Ishihara T, Ohtsuka M, Miyazaki M, Yokosuka O: Endoscopic diagnosis of intraductal papillary mucinous neoplasm of the bile duct. J Hepatobiliary Pancreat Sci; 2010 May;17(3):230-5
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  • [Title] Endoscopic diagnosis of intraductal papillary mucinous neoplasm of the bile duct.
  • BACKGROUND/PURPOSE: Intraductal papillary mucinous neoplasm of the bile duct (IPMN-B) is considered an uncommon tumor.
  • POCS was carried out after ERC and it showed the presence and locations of papillary tumors in all patients, except for one with a tumor in the peripheral intrahepatic bile duct (B3).
  • Six of the eight patients underwent surgical treatment; five patients underwent a hepatic resection with or without extrahepatic bile duct resection and one underwent a pancreaticoduodenectomy.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Papillary / pathology. Bile Duct Neoplasms / diagnosis. Bile Ducts, Extrahepatic. Bile Ducts, Intrahepatic. Endoscopy, Gastrointestinal

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  • (PMID = 19669677.001).
  • [ISSN] 1868-6982
  • [Journal-full-title] Journal of hepato-biliary-pancreatic sciences
  • [ISO-abbreviation] J Hepatobiliary Pancreat Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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11. Zen Y, Sasaki M, Fujii T, Chen TC, Chen MF, Yeh TS, Jan YY, Huang SF, Nimura Y, Nakanuma Y: Different expression patterns of mucin core proteins and cytokeratins during intrahepatic cholangiocarcinogenesis from biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct--an immunohistochemical study of 110 cases of hepatolithiasis. J Hepatol; 2006 Feb;44(2):350-8
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  • [Title] Different expression patterns of mucin core proteins and cytokeratins during intrahepatic cholangiocarcinogenesis from biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct--an immunohistochemical study of 110 cases of hepatolithiasis.
  • BACKGROUND/AIMS: Two types of neoplastic lesions preceding invasive intrahepatic cholangiocarcinoma (ICC) are identified: a flat-type neoplastic lesion called 'biliary intraepithelial neoplasia (BilIN)' and an intraductal papillary neoplasm of the bile duct (IPN-B).
  • IPN-B was characterized by the intestinal phenotype (MUC2+/CK20+), and carcinogenesis leading to tubular adenocarcinoma was associated with increasing MUC1 expression and that to colloid carcinoma with MUC1-negativity.
  • Pathological stages of tubular adenocarcinoma of ICC with BilIN or IPN-B were more advanced than those of colloid carcinoma with IPN-B.
  • Increased expression of MUC1 in BilIN and also IPN-B is associated with tubular adenocarcinoma, while colloid carcinoma in IPN-B is characterized by MUC1-negativity and less advanced pathologic stages.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / pathology. Cholelithiasis / pathology. Keratins / biosynthesis. Mucins / biosynthesis
  • [MeSH-minor] Biomarkers, Tumor / biosynthesis. Diagnosis, Differential. Disease Progression. Humans. Immunohistochemistry. Neoplasm Staging. Precancerous Conditions

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  • [CommentIn] J Hepatol. 2006 Feb;44(2):249-50 [16360969.001]
  • (PMID = 16360234.001).
  • [ISSN] 0168-8278
  • [Journal-full-title] Journal of hepatology
  • [ISO-abbreviation] J. Hepatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins; 68238-35-7 / Keratins
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12. Lim JH, Jang KT, Choi D, Lee WJ, Lim HK: Early bile duct carcinoma: comparison of imaging features with pathologic findings. Radiology; 2006 Feb;238(2):542-8
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  • [Title] Early bile duct carcinoma: comparison of imaging features with pathologic findings.
  • PURPOSE: To retrospectively evaluate the imaging features of early bile duct carcinoma and to compare these features with histopathologic findings.
  • Twenty-one patients (13 men, eight women; mean age, 60 years; range, 48-75 years) with early bile duct carcinoma that was surgically resected and histopathologically confirmed were included.
  • Two radiologists retrospectively reviewed imaging features by consensus; they compared growth pattern of tumors, integrity of the bile duct wall that harbored the tumor, and periductal infiltration with histopathologic findings.
  • In four of the 10 intrahepatic cholangiocarcinomas, four of the five hilar cholangiocarcinomas, and six of the six extrahepatic cholangiocarcinomas, there were intraductal tumor masses and the wall of the tumor-bearing bile ducts was preserved without periductal infiltration on US and CT images.
  • CONCLUSION: Imaging features of early bile duct carcinoma are a tumor mass in the bile duct lumen and integrity of the tumor-bearing bile duct wall without infiltration outside the wall.
  • [MeSH-major] Adenocarcinoma / diagnosis. Bile Duct Neoplasms / diagnosis

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  • [Copyright] (c) RSNA, 2005
  • (PMID = 16396837.001).
  • [ISSN] 0033-8419
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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13. Levy M, Lin F, Xu H, Dhall D, Spaulding BO, Wang HL: S100P, von Hippel-Lindau gene product, and IMP3 serve as a useful immunohistochemical panel in the diagnosis of adenocarcinoma on endoscopic bile duct biopsy. Hum Pathol; 2010 Sep;41(9):1210-9
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  • [Title] S100P, von Hippel-Lindau gene product, and IMP3 serve as a useful immunohistochemical panel in the diagnosis of adenocarcinoma on endoscopic bile duct biopsy.
  • Histopathologic distinction between benign and malignant bile duct epithelial lesions on endoscopic biopsies can be extremely challenging because of limited material, crush artifact, and compounding inflammatory and/or reactive changes particularly after stent placement.
  • In this study, a total of 72 endoscopic bile duct biopsies, including 40 adenocarcinomas and 32 benign cases, were immunohistochemically examined for the expression of S100P, von Hippel-Lindau gene product (pVHL), and IMP3 to evaluate their diagnostic value.
  • In conclusion, an immunohistochemical panel consisting of S100P, pVHL, and IMP3 can be helpful in distinguishing adenocarcinoma from reactive epithelial changes on challenging bile duct biopsies.
  • [MeSH-major] Adenocarcinoma / diagnosis. Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic / pathology. Biomarkers, Tumor / analysis. Carrier Proteins / analysis. Nuclear Proteins / analysis. RNA-Binding Proteins / analysis. Von Hippel-Lindau Tumor Suppressor Protein / analysis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy. Carcinoma, Pancreatic Ductal / chemistry. Carcinoma, Pancreatic Ductal / diagnosis. Cholangiopancreatography, Endoscopic Retrograde. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Pancreatic Neoplasms / chemistry. Pancreatic Neoplasms / diagnosis. Precancerous Conditions / diagnosis

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • [CommentIn] Hum Pathol. 2011 Sep;42(9):1368; author reply 1368-9 [21704356.001]
  • (PMID = 20382408.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carrier Proteins; 0 / IMP3 protein, human; 0 / Nuclear Proteins; 0 / RNA-Binding Proteins; 0 / S100PBP protein, human; EC 6.3.2.19 / VHL protein, human; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
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14. Park HJ, Jang KT, Heo JS, Choi YL, Han J, Kim SH: A potential case of intraductal tubulopapillary neoplasms of the bile duct. Pathol Int; 2010 Sep;60(9):630-5
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  • [Title] A potential case of intraductal tubulopapillary neoplasms of the bile duct.
  • We experienced an unusual intraductal growing bile duct tumor, which showed the same histopathologic and immunostaining profiles as ITPN of pancreas.
  • A 72-year-old female patient visited hospital due to intrahepatic stone.
  • The hilar bile duct tumor was detected and incidental lung mass was found in systemic evaluation.
  • The lung tumor was an adenocarcinoma, and the bile duct tumor showed poorly differentiated carcinoma with eosinophilic cytoplasm.
  • Lung lobectomy and hemihepatectomy were performed under the impression of double primary neoplasms of the lung adenocarcinoma and oncocytic variant of the biliary papillary tumor.
  • Both the lung and bile duct tumors showed a tubulopapillary pattern with high-grade nuclear atypia.
  • Eosinophilic cytoplasm of the bile duct tumor was not oncocytic cytoplasm but pyknotic change due to necrosis.
  • Here, we report the first case of ITPN of the bile duct with lung metastasis.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Bile Duct Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Adenocarcinoma / surgery. Aged. Carcinoma, Intraductal, Noninfiltrating / diagnosis. Carcinoma, Intraductal, Noninfiltrating / secondary. Carcinoma, Intraductal, Noninfiltrating / surgery. Female. Humans. Lung Neoplasms / diagnosis. Lung Neoplasms / secondary. Lung Neoplasms / surgery. Treatment Outcome

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  • (PMID = 20712650.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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15. Itoi T, Sofuni A, Itokawa F, Tsuchiya T, Kurihara T: Evaluation of peroral videocholangioscopy using narrow-band imaging for diagnosis of intraductal papillary neoplasm of the bile duct. Dig Endosc; 2009 Jul;21 Suppl 1:S103-7
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  • [Title] Evaluation of peroral videocholangioscopy using narrow-band imaging for diagnosis of intraductal papillary neoplasm of the bile duct.
  • BACKGROUND: It is very important for intraductal papillary neoplasm of the bile duct (IPNB) to determine the extension of the neoplasms because of substantial differences in the approach to treatment strategy.
  • The aim of this study is to evaluate the clinical usefulness of PVCS using NBI for the diagnosis of IPNB.
  • We evaluated endoscopic imaging of white light imaging (WLI) and NBI for IPNB lesions, and ability of removing mucin in the bile duct by PVCS.
  • In the ability to detect the fine mucosal structure, NBI was predisposed to be better than conventional imaging while only one case was "poor" by NBI observation because we could not eliminate the influence of bile.
  • Although further cases should be accumulated, choledochoscopy using NBI may be helpful for the observation of fine mucosal structures, resulting in diagnosis of tumor spread in patients with IPNB.
  • [MeSH-major] Adenocarcinoma / diagnosis. Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic. Carcinoma, Papillary / diagnosis. Endoscopes, Gastrointestinal. Endoscopy, Gastrointestinal / methods. Video Recording / methods
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Equipment Design. Female. Humans. Male

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  • (PMID = 19691722.001).
  • [ISSN] 1443-1661
  • [Journal-full-title] Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
  • [ISO-abbreviation] Dig Endosc
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Australia
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16. Nakanishi Y, Zen Y, Hirano S, Tanaka E, Takahashi O, Yonemori A, Doumen H, Kawakami H, Itoh T, Nakanuma Y, Kondo S: Intraductal oncocytic papillary neoplasm of the bile duct: the first case of peribiliary gland origin. J Hepatobiliary Pancreat Surg; 2009;16(6):869-73
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  • [Title] Intraductal oncocytic papillary neoplasm of the bile duct: the first case of peribiliary gland origin.
  • We report herein the first case of intraductal oncocytic papillary neoplasm of the bile duct arising from a peribiliary gland of the left hepatic duct.
  • Radiological and cholangioscopic examinations revealed intraductal tumor of the left hepatic duct.
  • After pathological diagnosis of adenocarcinoma by cholangioscopic biopsy, a surgical hepatobiliary resection was performed.
  • Pathological examination revealed papillary tumor in the left hepatic duct.
  • Interestingly, this tumor originated from the cystic space in the bile duct wall.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Carcinoma in Situ / pathology

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  • (PMID = 19322511.001).
  • [ISSN] 1436-0691
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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17. Carter RR, Woodall CE 3rd, McNally ME, Talboy GE, Lankachandra KM, Van Way CW 3rd: Mixed ductal-endocrine carcinoma of the pancreas with synchronous papillary carcinoma-in-situ of the common bile duct: a case report and literature review--synchronous pancreatic and bile duct tumors. Am Surg; 2008 Apr;74(4):338-40
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  • [Title] Mixed ductal-endocrine carcinoma of the pancreas with synchronous papillary carcinoma-in-situ of the common bile duct: a case report and literature review--synchronous pancreatic and bile duct tumors.
  • This report is a case of a 58-year-old woman with a mixed ductal-endocrine carcinoma of the pancreas and a synchronous carcinoma-in-situ of the common bile duct.
  • Magnetic resonance imaging scan showed dilated intrahepatic biliary and common bile ducts.
  • Biopsies from this lesion showed adenocarcinoma.
  • Subsequently, pancreatoduodenectomy was performed for the diagnosis of peri-ampullary carcinoma.
  • Gross examination revealed a 2-cm irregular, ulcerated lesion obstructing the distal 0.5 cm of the common bile duct within the head of the pancreas.
  • On histopathological examination, it was discovered that this lesion contained two separate neoplasms: papillary carcinoma-in-situ of the intraparenchymal portion of the common bile duct and a mixed ductal-endocrine carcinoma of the pancreas.
  • Finding it in conjunction with a synchronous, overlying papillary carcinoma carcinoma-in-situ of the common bile duct has not been previously described.
  • [MeSH-major] Carcinoma in Situ / pathology. Carcinoma, Pancreatic Ductal / pathology. Common Bile Duct Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 18453301.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 8
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18. Dechaphunkul A, Kanngurn S, Dechsukhum C, Tanutit P, Khow-Ean U, Sunpaweravong P: The significance of galectin-3 immunohistochemistry, clinical characteristics and liver imaging in differentiating intrahepatic cholangiocarcinoma from adenocarcinoma liver metastasis. J Med Assoc Thai; 2010 May;93(5):523-8
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  • [Title] The significance of galectin-3 immunohistochemistry, clinical characteristics and liver imaging in differentiating intrahepatic cholangiocarcinoma from adenocarcinoma liver metastasis.
  • OBJECTIVE: To identify differences of Galectin-3 (Gal-3) immunostaining, clinical profiles, and images in patients with intrahepatic cholangiocarcinoma (IHC) and adenocarcinoma liver metastasis, and be able to recognize these parameters as diagnostic tools for differentiating these two diseases.
  • MATERIAL AND METHOD: Histological slides from patients with IHC and adenocarcinoma liver metastasis were reviewed Immunohistochemical staining for Gal-3, Cytokeratin-7 (CK-7), and Cytokeratin-20 (CK-20) was performed and the results categorized.
  • RESULTS: Eighty-two patients were evaluated, 31 IHC and 51 adenocarcinoma liver metastasis.
  • Finding showed that 86% of them were IHC whereas only 14% were in adenocarcinoma liver metastasis.
  • All patients with liver images showing a single lesion, located at central site, and having intrahepatic duct dilatation were IHC.
  • On the other hand, 77% of patients with liver imaging showing multiple liver masses, located at peripheral site and having no intrahepatic duct dilatation were adenocarcinoma liver metastasis while only 23% were in IHC.
  • CONCLUSION: Adding Gal-3 to CK-7 and CK-20 immunohistochemistry has benefits to differentiate IHC from adenocarcinoma liver metastasis.
  • [MeSH-major] Adenocarcinoma / diagnosis. Bile Duct Neoplasms / diagnosis. Cholangiocarcinoma / diagnosis. Galectin 3 / metabolism. Liver Neoplasms / diagnosis
  • [MeSH-minor] Adult. Bile Ducts, Intrahepatic / metabolism. Bile Ducts, Intrahepatic / pathology. Biomarkers, Tumor / metabolism. Female. Humans. Immunohistochemistry. Keratin-20 / metabolism. Keratin-7 / metabolism. Liver / radiography. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 20524437.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Galectin 3; 0 / Keratin-20; 0 / Keratin-7
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19. Kaiho T, Tanaka T, Tsuchiya S, Yanagisawa S, Takeuchi O, Miura M, Saigusa N, Hayasaka A, Matsuzaki O, Miyazaki M: A case of small cell carcinoma of the common bile duct. Hepatogastroenterology; 2005 Mar-Apr;52(62):363-7
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  • [Title] A case of small cell carcinoma of the common bile duct.
  • We report a case of small cell carcinoma which occurred in the common bile duct.
  • Computed tomography and ultrasonography showed a mass near the pancreas head and dilatation of the intrahepatic bile ducts.
  • Endoscopic nasobiliary drainage was undertaken, and it revealed obstruction of the common bile duct.
  • The patient was diagnosed preoperatively as having extrahepatic bile duct cancer.
  • Upon laparotomy, a tumor was found to be located in the middle common bile duct.
  • Postoperative pathological examination revealed well-differentiated papillary adenocarcinoma on the surface of the bile duct lumen, but a large part of the extraductal component was small cell carcinoma.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Carcinoma, Small Cell / diagnosis. Common Bile Duct

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  • (PMID = 15816436.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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20. Nanashima A, Kinoshita N, Nakanuma Y, Zen Y, Sumida Y, Abo T, Hidaka S, Takeshita H, Yasutake T, Hayashi T, Nagayasu T: Clinicopathological features of "intraductal papillary neoplasm of the bile duct" and patient outcome after surgical resection. Hepatogastroenterology; 2008 Jul-Aug;55(85):1167-73
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  • [Title] Clinicopathological features of "intraductal papillary neoplasm of the bile duct" and patient outcome after surgical resection.
  • BACKGROUND/AIMS: Intraductal papillary neoplasm of the bile duct (IPNB) represents a biliary papillary tumor mainly growing in the bile duct lumen resembling intraductal papillary mucin-producing neoplasm of the pancreas.
  • Imagery showed cystic or diffuse dilatation of the bile ducts.
  • Tumor markers were not valuable for diagnosis.
  • All patients underwent hemihepatectomy with or without resection of the caudate lobe or extrahepatic bile duct.
  • Five cases were well-differentiated adenocarcinoma and 1 had poorly differentiated adenocarcinoma.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic. Carcinoma / pathology. Carcinoma / surgery

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  • (PMID = 18795651.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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21. Zhao SM, Zhu XZ, Ji Y, Hou J: [Expression of mucin glycoproteins and cytokeratins in intrahepatic cholangiocarcinoma]. Zhonghua Bing Li Xue Za Zhi; 2008 Nov;37(11):749-53
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  • [Title] [Expression of mucin glycoproteins and cytokeratins in intrahepatic cholangiocarcinoma].
  • OBJECTIVE: To compare the immunoprofiles of intrahepatic cholangiocarcinoma and metastatic colorectal adenocarcinoma for mucin glycoproteins (including MUC1, MUC2, MUC5AC and MUC6) and cytokeratins (including CK7, CK19 and CK20), and to assess their diagnostic value.
  • METHODS: One hundred cases of intrahepatic cholangiocarcinoma and 21 cases of metastatic colorectal adenocarcinoma were enrolled into the study.
  • RESULTS: In intrahepatic cholangiocarcinoma, the expression rates of MUC1, MUC2, MUC5AC and MUC6 were 61.0%, 2.0%, 22.0% and 8.0% respectively, as compared to 57.1%, 47.6%, 19.0% and 23.8% respectively in metastatic colorectal adenocarcinoma.
  • On the other hand, the expression rates of CK7, CK19 and CK20 in intrahepatic cholangiocarcinoma were 73.0%, 53.0% and 15.0% respectively, in contrast to 14.3%, 90.5% and 85.7% respectively in metastatic colorectal adenocarcinoma.
  • CONCLUSIONS: The immunoprofile for mucin glycoproteins and cytokeratins provides important clues in distinguishing between intrahepatic cholangiocarcinoma and metastatic colorectal adenocarcinoma to liver.
  • The immunophenotype of MUC2-/MUC6-/CK7+/CK20- indicates the diagnosis of intrahepatic cholangiocarcinoma, while MUC2+/MUC6+/CK7-/CK20+ suggests the possibility of metastatic colorectal adenocarcinoma.
  • [MeSH-major] Bile Duct Neoplasms / metabolism. Bile Ducts, Intrahepatic / pathology. Biomarkers, Tumor / analysis. Cholangiocarcinoma / metabolism. Keratins / metabolism. Mucins / metabolism
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Aged. Colorectal Neoplasms / metabolism. Colorectal Neoplasms / pathology. Female. Glycoproteins / metabolism. Humans. Male. Middle Aged. Neoplasm Staging / classification

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  • (PMID = 19094709.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glycoproteins; 0 / Mucins; 68238-35-7 / Keratins
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22. Ghittoni G, Caturelli E, Viera FT: Intrabile duct metastasis from colonic adenocarcinoma without liver parenchyma involvement: contrast enhanced ultrasonography detection. Abdom Imaging; 2010 Jun;35(3):346-8

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  • [Title] Intrabile duct metastasis from colonic adenocarcinoma without liver parenchyma involvement: contrast enhanced ultrasonography detection.
  • It is well-known that biliary duct invasion with intraluminal growth is one of the developmental patterns of primary liver tumors, and macroscopic intrabiliary growth of liver metastases in colorectal cancer is found with high frequency.
  • However, many patients die of intrahepatic and/or extrahepatic recurrence after the resection.
  • We describe the first recorded case of a metastasis from colorectal cancer involving solely the common hepatic biliary duct, without invasion of contiguous liver parenchyma.
  • A correct diagnosis was obtained by means of contrast enhanced ultrasound and ultrasound-guided fine needle aspiration biopsy.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Colonic Neoplasms / pathology. Hepatic Duct, Common / pathology. Ultrasonography, Doppler, Color
  • [MeSH-minor] Aged. Biopsy, Fine-Needle. Cholangiography. Common Bile Duct / pathology. Common Bile Duct / ultrasonography. Humans. Image Enhancement. Lymphatic Metastasis. Male. Neoplasm Invasiveness

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  • (PMID = 19294464.001).
  • [ISSN] 1432-0509
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Mannai S, Kraïem T, Gharbi L, Haoues N, Mestiri H, Khalfallah MT: [Congenital cystic dilatation of bile ducts]. Ann Chir; 2006 Jul-Aug;131(6-7):369-74
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  • [Title] [Congenital cystic dilatation of bile ducts].
  • Congenital cystic dilatation of bile ducts is a rare condition.
  • We report a retrospective study about 18 patients having congenital bile duct cysts.
  • Anatomopathologic examination showed an adenocarcinoma of a common bile duct cyst.
  • In one case, a cancer of the gall bladder associated to a common bile duct cyst in another case.
  • Three patients with segmental dilatation of intrahepatic bile ducts (type V) underwent liver resection.
  • Congenital cystic dilatation of bile ducts is considered to be a precancer state.
  • [MeSH-major] Bile Duct Diseases / congenital. Bile Ducts / abnormalities. Choledochal Cyst. Cysts / congenital
  • [MeSH-minor] Acute Disease. Adolescent. Adult. Aged. Aged, 80 and over. Anastomosis, Surgical. Bile Ducts, Intrahepatic / abnormalities. Caroli Disease / diagnosis. Caroli Disease / surgery. Child. Child, Preschool. Cholangitis / etiology. Cholecystitis / complications. Dilatation. Dilatation, Pathologic / congenital. Drainage. Female. Hepatectomy. Humans. Jejunum / surgery. Liver / surgery. Male. Middle Aged. Postoperative Complications. Retrospective Studies

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  • (PMID = 16630531.001).
  • [ISSN] 0003-3944
  • [Journal-full-title] Annales de chirurgie
  • [ISO-abbreviation] Ann Chir
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
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24. Nishino R, Honda M, Yamashita T, Takatori H, Minato H, Zen Y, Sasaki M, Takamura H, Horimoto K, Ohta T, Nakanuma Y, Kaneko S: Identification of novel candidate tumour marker genes for intrahepatic cholangiocarcinoma. J Hepatol; 2008 Aug;49(2):207-16
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  • [Title] Identification of novel candidate tumour marker genes for intrahepatic cholangiocarcinoma.
  • BACKGROUND/AIMS: Specific markers are required for early detection and diagnosis of intrahepatic cholangiocarcinoma (ICC); however, the tumour markers currently in use are not specific for ICC.
  • Moreover, discrimination analysis revealed that a combination of these genes could be used to distinguish ICC from HCC or metastatic adenocarcinoma.
  • CONCLUSIONS: We identified novel marker genes of ICC that are potentially useful for the diagnosis of liver cancer.
  • [MeSH-major] Bile Duct Neoplasms / genetics. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Biomarkers, Tumor / genetics. Cholangiocarcinoma / genetics. Cholangiocarcinoma / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Male. Middle Aged. Oligonucleotide Array Sequence Analysis. Reverse Transcriptase Polymerase Chain Reaction

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  • [CommentIn] J Hepatol. 2008 Aug;49(2):160-2 [18538440.001]
  • (PMID = 18490072.001).
  • [ISSN] 0168-8278
  • [Journal-full-title] Journal of hepatology
  • [ISO-abbreviation] J. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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25. Kitagawa D, Taketomi A, Aishima S, Kuroda Y, Gion T, Shirabe K, Shimada M, Maehara Y: Recurrence of intrahepatic cholangiocarcinoma nine years after surgical resection. Hepatogastroenterology; 2008 May-Jun;55(84):1085-8
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  • [Title] Recurrence of intrahepatic cholangiocarcinoma nine years after surgical resection.
  • This paper reports a rare case of intrahepatic cholangiocarcinoma (ICC) which recurred nine years after surgical resection.
  • The resected specimen showed well differentiated adenocarcinoma, which consisted of chiefly intraductal growth component.
  • [MeSH-major] Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic / surgery. Cholangiocarcinoma / surgery. Neoplasm Recurrence, Local / surgery
  • [MeSH-minor] Antigens, Neoplasm / blood. Biomarkers, Tumor / blood. Diagnosis, Differential. Female. Follow-Up Studies. Hepatectomy. Humans. Liver Function Tests. Lymph Node Excision. Middle Aged. Reoperation. Tomography, X-Ray Computed

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  • (PMID = 18705334.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / DU-PAN-2 antigen, human; 0 / pancreatic associated antigen, SPan-1
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26. Okamura N, Yoshida M, Shibuya A, Sugiura H, Okayasu I, Ohbu M: Cellular and stromal characteristics in the scirrhous hepatocellular carcinoma: comparison with hepatocellular carcinomas and intrahepatic cholangiocarcinomas. Pathol Int; 2005 Nov;55(11):724-31
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  • [Title] Cellular and stromal characteristics in the scirrhous hepatocellular carcinoma: comparison with hepatocellular carcinomas and intrahepatic cholangiocarcinomas.
  • Diagnosis was on the basis of a scirrhous histological pattern exceeding 50% of the tumor area.
  • Expression of cytoplasmic and extracellular matrix proteins was compared among SHCC, HCC and intrahepatic cholangiocarcinoma (ICC) cases with immunohistochemical staining.
  • [MeSH-major] Adenocarcinoma, Scirrhous / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Carcinoma, Hepatocellular / pathology. Cholangiocarcinoma / pathology. Liver Neoplasms / pathology

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  • (PMID = 16271085.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Collagen Type I; 0 / Collagen Type III; 0 / Laminin; 0 / Tenascin; 103107-01-3 / Fibroblast Growth Factor 2; 68238-35-7 / Keratins; EC 3.4.24.23 / Matrix Metalloproteinase 7
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27. Nart D, Ertan Y, Pala EE, Zeytunlu M, Kilic M, Yilmaz F: Intrahepatic cholangiocarcinoma arising in chronic viral hepatitis-associated cirrhosis: two transplant cases. Transplant Proc; 2008 Dec;40(10):3813-5
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  • [Title] Intrahepatic cholangiocarcinoma arising in chronic viral hepatitis-associated cirrhosis: two transplant cases.
  • Recently, these viruses have been reported to have an etiologic role in the development of intrahepatic cholangiocarcinoma (ICC).
  • Herein we have reported two cases of HCV- and HBV-related cirrhosis with ICC in whom the pretransplant diagnosis was HCC.
  • On microscopic examination, all nodules exhibited typical morphological findings of adenocarcinoma.
  • In cirrhotic patients with active malignancy who are candidates for LDLT, ICC should be considered in the differential diagnosis.
  • [MeSH-major] Bile Duct Neoplasms / etiology. Bile Ducts, Intrahepatic. Cholangiocarcinoma / etiology. Hepatitis B / complications. Hepatitis B / surgery. Hepatitis C, Chronic / complications. Hepatitis C, Chronic / surgery. Liver Transplantation


28. Shimamura K, Kurosaki I, Sato D, Takano K, Yokoyama N, Sato Y, Hatakeyama K, Nakadaira K, Yagi M: Intrahepatic cholangiocarcinoma arising 34 years after excision of a type IV-A congenital choledochal cyst: report of a case. Surg Today; 2009;39(3):247-51
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  • [Title] Intrahepatic cholangiocarcinoma arising 34 years after excision of a type IV-A congenital choledochal cyst: report of a case.
  • We report a rare case of intrahepatic cholangiocarcinoma (IHCC) arising many years after excision of a type IV-A congenital choledochal cyst.
  • Although he had no jaundice, the intrahepatic bile ducts showed cylinder-like dilatation with narrowing of the hilar bile duct.
  • At surgery, the tumor was found to arise from the dilated intrahepatic bile duct just above the narrow portion.
  • Microscopically, the tumor was confirmed to be moderate-to-well-differentiated tubular adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / etiology. Bile Duct Neoplasms / diagnosis. Bile Duct Neoplasms / etiology. Bile Ducts, Intrahepatic. Cholangiocarcinoma / etiology. Choledochal Cyst / complications. Choledochal Cyst / surgery

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  • (PMID = 19280286.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 31
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29. Chu PG, Schwarz RE, Lau SK, Yen Y, Weiss LM: Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2. Am J Surg Pathol; 2005 Mar;29(3):359-67
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  • [Title] Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2.
  • We studied the expression of cytokeratin 7 (CK7), cytokeratin 17 (CK17), cytokeratin 20 (CK20), CDX2, mucin 1 (MUC1), mucin 2 (MUC2), and mucin 5AC (MUC5AC) in 46 cases of pancreatic ductal carcinoma, 18 ampulla of Vater adenocarcinomas, and 24 intrahepatic cholangiocarcinomas.
  • The expression of MUC1 and CK17 was restricted to pancreatic ductal carcinoma (41 of 46, 89%; 38 of 46, 83%, respectively), the ampullary carcinoma of pancreatobiliary origin (6 of 6, 100%; 5 of 6, 83%, respectively), and intrahepatic cholangiocarcinoma (20 of 24, 83%; 17 of 24, 71%, respectively).
  • MUC2 was rarely expressed in pancreatic ductal carcinoma (1 of 46, 2%) and was negative in the ampullary carcinoma of pancreatobiliary origin and in intrahepatic cholangiocarcinoma.
  • A heterogeneous CDX2 staining pattern was seen in 1 of 6 cases of the ampullary carcinoma of pancreatobiliary origin (17%), 5 of 24 intrahepatic cholangiocarcinomas (21%), and 10 of 46 (22%) pancreatic ductal carcinomas.
  • MUC2+/CDX2+ can be used as positive markers for the intestinal-type adenocarcinoma of duodenal papillary origin with a positive predictive value of 82%.
  • [MeSH-major] Ampulla of Vater / pathology. Bile Ducts, Intrahepatic / pathology. Carcinoma, Pancreatic Ductal / pathology. Cholangiocarcinoma / pathology. Common Bile Duct Neoplasms / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Biomarkers, Tumor / metabolism. Female. Homeodomain Proteins / metabolism. Humans. Immunohistochemistry. Keratins / metabolism. Male. Mucins / metabolism. Neoplasm Proteins / metabolism

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  • (PMID = 15725805.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / Mucins; 0 / Neoplasm Proteins; 68238-35-7 / Keratins
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30. Seshadri RA, Majhi U: Endobiliary metastasis from rectal cancer mimicking intrahepatic cholangiocarcinoma: a case report and review of literature. J Gastrointest Cancer; 2009;40(3-4):123-7
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  • [Title] Endobiliary metastasis from rectal cancer mimicking intrahepatic cholangiocarcinoma: a case report and review of literature.
  • PURPOSE: The purpose of this study is to report an unusual case of liver metastasis from carcinoma rectum, which mimicked an intrahepatic cholangiocarcinoma (ICC) radiologically and pathologically, and to review the relevant literature.
  • Two years later, he was found to have a nodule in the left hepatic duct on imaging.
  • FINDINGS: The specimen revealed a tumor in the left hepatic duct, microscopically resembling an ICC.
  • [MeSH-major] Adenocarcinoma / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / pathology. Liver Neoplasms / secondary. Rectal Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Diagnosis, Differential. Digestive System Surgical Procedures. Humans. Immunohistochemistry. Keratin-20 / metabolism. Keratin-7 / metabolism. Magnetic Resonance Imaging. Male. Middle Aged. Neoadjuvant Therapy. Neoplasm Staging. Radiotherapy

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  • (PMID = 19921471.001).
  • [ISSN] 1941-6636
  • [Journal-full-title] Journal of gastrointestinal cancer
  • [ISO-abbreviation] J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratin-20; 0 / Keratin-7
  • [Number-of-references] 17
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31. Sato K, Murai H, Ueda Y, Katsuda S: Intrahepatic sarcomatoid cholangiocarcinoma of round cell variant: a case report and immunohistochemical studies. Virchows Arch; 2006 Nov;449(5):585-90
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  • [Title] Intrahepatic sarcomatoid cholangiocarcinoma of round cell variant: a case report and immunohistochemical studies.
  • Sarcomatoid transformation was observed in 4.5% of autopsied cases of intrahepatic cholangiocarcinoma.
  • Here, we report a case of intrahepatic sarcomatoid cholangiocarcinoma with round cell feature, extremely rare variant.
  • The patient was clinically diagnosed to have intrahepatic cholangiocarcinoma and received palliative care without specific treatment.
  • He died of hepatic insufficiency 3 months after the diagnosis.
  • Histologically, the tumor was centrally hemorrhagic and necrotic and was composed of tubular adenocarcinoma and a round cell component, which has an eccentrically located nucleus and eosinophilic cytoplasm without mucin production.
  • Immunohistochemically, the adenocarcinoma cells expressed cytokeratin 19 and beta-catenin in their cytoplasm, with E-cadherin and CD44s at the plasma membrane.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic. Cholangiocarcinoma / pathology

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  • (PMID = 17033799.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD44; 0 / Cadherins; 0 / beta Catenin
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32. Paik KY, Heo JS, Choi SH, Choi DW: Intraductal papillary neoplasm of the bile ducts: the clinical features and surgical outcome of 25 cases. J Surg Oncol; 2008 May 1;97(6):508-12
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  • [Title] Intraductal papillary neoplasm of the bile ducts: the clinical features and surgical outcome of 25 cases.
  • BACKGROUND AND OBJECTIVES: Intraductal papillary neoplasm of the bile ducts (IPN-B) is considered an uncommon tumor.
  • Radiologically, 23 of the 25 (92.0%) showed bile duct dilatation, bile duct dilatation with or without an intraductal mass, and cystic changes of bile ducts.
  • Twenty three of the 25 patients underwent hepatic resection with or without extrahepatic bile duct resection.
  • CONCLUSIONS: A diagnosis of IPN-B is usually made in patients with biliary dilatation by radiologic study.
  • [MeSH-major] Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic / surgery. Carcinoma, Papillary / surgery
  • [MeSH-minor] Adenocarcinoma, Mucinous / secondary. Adenocarcinoma, Mucinous / surgery. Adult. Aged. Cholangiocarcinoma / secondary. Cholangiocarcinoma / surgery. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local / diagnosis. Prognosis. Survival Rate. Treatment Outcome

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 18314868.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Khunamornpong S, Siriaunkgul S, Suprasert P, Pojchamarnwiputh S, Na Chiangmai W, Young RH: Intrahepatic cholangiocarcinoma metastatic to the ovary: a report of 16 cases of an underemphasized form of secondary tumor in the ovary that may mimic primary neoplasia. Am J Surg Pathol; 2007 Dec;31(12):1788-99
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  • [Title] Intrahepatic cholangiocarcinoma metastatic to the ovary: a report of 16 cases of an underemphasized form of secondary tumor in the ovary that may mimic primary neoplasia.
  • The potential for adenocarcinoma metastatic to the ovary to mimic primary mucinous neoplasms is a well-known issue to surgical pathologists, most of the recent literature emphasizing pancreatic and various other origins for the ovarian metastases.
  • Although an origin in the gallbladder or extrahepatic bile ducts is acknowledged for some cases little information exists on tumors originating within the intrahepatic bile ducts.
  • Intrahepatic cholangiocarcinoma should be included in the list of origins of possible ovarian metastatic tumors that mimic primary ovarian mucinous neoplasia, particularly in parts of the world where cholangiocarcinoma of the liver is relatively common.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Cholangiocarcinoma / secondary. Ovarian Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Bile Ducts, Intrahepatic / pathology. Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 18043033.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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34. Fraguela Mariña JA, Fernández Blanco C, Alonso Fernández L, Taboada Filgueira L, Robles Veiga O, Gómez Freijoso C: [Liver metastases from colonic adenocarcinoma simulating cholangiocarcinoma]. Gastroenterol Hepatol; 2007 Oct;30(8):454-6
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  • [Title] [Liver metastases from colonic adenocarcinoma simulating cholangiocarcinoma].
  • Macroscopic intrabiliary growth of liver metastases from colonic adenocarcinoma mimicking cholangiocarcinoma, a pattern of intrahepatic spread easily confused with primary neoplasia of the biliary tract, is extremely infrequent.
  • We report a case of metastasis from adenocarcinoma of the colon that presented as a Klatskin tumor.
  • The definitive diagnosis was established by immunostaining.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Bile Duct Neoplasms / diagnosis. Cholangiocarcinoma / diagnosis. Colonic Neoplasms / pathology. Klatskin Tumor / diagnosis. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 17949611.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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35. Lim JH, Jang KT, Choi D: Biliary intraductal papillary-mucinous neoplasm manifesting only as dilatation of the hepatic lobar or segmental bile ducts: imaging features in six patients. AJR Am J Roentgenol; 2008 Sep;191(3):778-82
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  • [Title] Biliary intraductal papillary-mucinous neoplasm manifesting only as dilatation of the hepatic lobar or segmental bile ducts: imaging features in six patients.
  • OBJECTIVE: The purpose of this study was to evaluate the imaging features of intrahepatic biliary intraductal papillary-mucinous neoplasm manifesting only as dilatation of the lobar or segmental bile ducts without a visible mass to determine whether this type of cholangiocarcinoma can be recognized on the basis of distinct imaging features.
  • CONCLUSION: Intrahepatic biliary intraductal papillary-mucinous neoplasm can spread along the mucosa without forming a mass and can produce a large amount of mucin.
  • Severe dilatation of the lobar or segmental intrahepatic bile ducts with crowding and severe atrophy of the hepatic parenchyma are helpful imaging findings.
  • [MeSH-major] Adenocarcinoma, Mucinous / radiography. Adenoma / radiography. Bile Duct Neoplasms / radiography. Liver Diseases / radiography. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Aged. Diagnosis, Differential. Dilatation, Pathologic. Female. Humans. Male. Middle Aged

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  • (PMID = 18716109.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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36. Yamamoto M, Otsubo T, Ariizumi S, Nakano M, Takasaki K: Intrahepatic cholangiocarcinoma detected by elevated levels of alpha-fetoprotein-L3 after hepatectomy for hepatocellular carcinoma in a patient with Budd-Chiari syndrome. Int Surg; 2005 Apr-Jun;90(2):81-4
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  • [Title] Intrahepatic cholangiocarcinoma detected by elevated levels of alpha-fetoprotein-L3 after hepatectomy for hepatocellular carcinoma in a patient with Budd-Chiari syndrome.
  • We report the case of a 57-year-old woman with Budd-Chiari syndrome, hepatocellular carcinoma (HCC), and intrahepatic cholangiocarcinoma (ICC).
  • Microscopic examination showed that tubular adenocarcinoma and immunohistochemical staining was focally positive for AFP.
  • [MeSH-major] Bile Duct Neoplasms / blood. Bile Ducts, Intrahepatic. Carcinoma, Hepatocellular / surgery. Cholangiocarcinoma / blood. Liver Neoplasms / surgery. alpha-Fetoproteins / analysis
  • [MeSH-minor] Budd-Chiari Syndrome / complications. Budd-Chiari Syndrome / diagnosis. Female. Hepatectomy / adverse effects. Humans. Middle Aged


37. Higuchi R, Yamamoto M, Hatori T, Shimizu K, Imai K, Takasaki K: Intrahepatic cholangiocarcinoma with lymph node metastasis successfully treated by immunotherapy with CD3-activated T cells and dendritic cells after surgery: report of a case. Surg Today; 2006;36(6):559-62
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  • [Title] Intrahepatic cholangiocarcinoma with lymph node metastasis successfully treated by immunotherapy with CD3-activated T cells and dendritic cells after surgery: report of a case.
  • Intrahepatic cholangiocarcinoma (ICC) with lymph node (LN) metastasis is generally associated with a poor prognosis.
  • Pathological examination confirmed a diagnosis of moderately differentiated adenocarcinoma with LN metastasis and portal vein invasion.
  • [MeSH-major] Adenocarcinoma / therapy. Antigens, CD3 / immunology. Bile Duct Neoplasms / therapy. Bile Ducts, Intrahepatic. Cholangiocarcinoma / therapy. Dendritic Cells / immunology. Immunotherapy / methods. T-Lymphocytes / immunology

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  • (PMID = 16715430.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, CD3
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38. Gütgemann I, Haas S, Berg JP, Zhou H, Büttner R, Fischer HP: CD56 expression aids in the differential diagnosis of cholangiocarcinomas and benign cholangiocellular lesions. Virchows Arch; 2006 Apr;448(4):407-11
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  • [Title] CD56 expression aids in the differential diagnosis of cholangiocarcinomas and benign cholangiocellular lesions.
  • In this study, we systematically examined CD56 expression on 98 tumours arising from the biliary tree as well as intrahepatic conditions with reactive neoductules.
  • Reactive bile ductules adjacent to cirrhotic nodules as well as in focal nodular hyperplasia were CD56 positive.
  • Twelve of 17 (70.5%) bile duct adenomas were CD56 positive, whereas von Meyenburg complexes expressed CD56 only very focally in less than 5% of lesional cells.
  • Bile duct cysts were negative for CD56 with the exception of focally interspersed neuroendocrine cells, similar to that seen in segmental bile ducts.
  • Thus, if van Meyenburg complexes are excluded, CD56 can be used to differentiate intrahepatic non-neoplastic from neoplastic proliferations, which is a helpful diagnostic tool in small liver biopsies.
  • [MeSH-major] Antigens, CD56 / metabolism. Bile Duct Neoplasms / metabolism. Bile Ducts, Intrahepatic / metabolism. Biomarkers, Tumor / metabolism. Cholangiocarcinoma / metabolism. Cholangitis / metabolism
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / metabolism. Adenoma, Bile Duct / diagnosis. Adenoma, Bile Duct / metabolism. Bile Ducts, Extrahepatic / metabolism. Bile Ducts, Extrahepatic / pathology. Choledochal Cyst / diagnosis. Choledochal Cyst / metabolism. Cystadenoma, Mucinous / diagnosis. Cystadenoma, Mucinous / metabolism. Diagnosis, Differential. Humans. Immunohistochemistry. Liver Cirrhosis / diagnosis. Liver Cirrhosis / metabolism

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  • (PMID = 16411132.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / Biomarkers, Tumor
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39. Tsou YK, Liu NJ, Wu RC, Lee CS, Tang JH, Hung CF, Jan YY: Endoscopic retrograde cholangiography in the diagnosis and treatment of mucobilia. Scand J Gastroenterol; 2008;43(9):1137-44
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  • [Title] Endoscopic retrograde cholangiography in the diagnosis and treatment of mucobilia.
  • OBJECTIVE: Some biliary neoplasms secrete copious mucin into bile ducts, yet the management of mucobilia is not well known.
  • ERC failed to show the tumors but a disproportionate or aneurysmal dilatation of the segmental or lobar duct correlated with the tumor-bearing duct was evident.
  • CONCLUSIONS: ERC revealed the tumor-bearing duct but not the extent of the disease in most of the patients with mucobilia.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / secretion. Adenocarcinoma, Papillary / diagnosis. Adenocarcinoma, Papillary / secretion. Bile Duct Neoplasms / diagnosis. Bile Duct Neoplasms / secretion. Mucins / secretion
  • [MeSH-minor] Aged. Bile Ducts, Intrahepatic / secretion. Cholangiopancreatography, Endoscopic Retrograde / methods. Cohort Studies. Drainage / methods. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. Risk Assessment. Sensitivity and Specificity. Treatment Outcome

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  • (PMID = 18609170.001).
  • [ISSN] 1502-7708
  • [Journal-full-title] Scandinavian journal of gastroenterology
  • [ISO-abbreviation] Scand. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Mucins
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40. Ono S, Sakai K, Kimura O, Iwai N: Development of bile duct cancer in a 26-year-old man after resection of infantile choledochal cyst. J Pediatr Surg; 2008 Jun;43(6):E17-9
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  • [Title] Development of bile duct cancer in a 26-year-old man after resection of infantile choledochal cyst.
  • Anomalous arrangement of the pancreaticobiliary duct is considered to be a high-risk factor for biliary tract malignancy.
  • We report a case of intrahepatic cholangiocarcinoma in a 26-year-old man after total resection of choledochal cyst with anomalous arrangement of the pancreaticobiliary duct at the age of 5 months.
  • Computed tomographic scan and percutaneous transhepatic cholangioscope revealed multiple stones and stenosis of the hepatic duct and the left intrahepatic bile duct.
  • Histologic examination of a biopsy specimen obtained from the stenotic site showed adenocarcinoma of the intrahepatic bile duct.
  • This report warns us that bile stasis owing to stenosis of the intrahepatic bile duct and repeated cholangitis with multiple stones are high-risk factors for carcinogenesis of the intrahepatic bile duct even after total resection of the infantile choledochal cyst.
  • [MeSH-major] Bile Duct Neoplasms / etiology. Bile Ducts, Intrahepatic. Cholangiocarcinoma / etiology. Choledochal Cyst / complications. Choledochal Cyst / surgery. Neoplasm Recurrence, Local / pathology. Precancerous Conditions

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  • (PMID = 18558159.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. Boberg KM, Jebsen P, Clausen OP, Foss A, Aabakken L, Schrumpf E: Diagnostic benefit of biliary brush cytology in cholangiocarcinoma in primary sclerosing cholangitis. J Hepatol; 2006 Oct;45(4):568-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: In this prospective case series we obtained brush cytology specimens from bile duct strictures in 61 consecutive PSC patients.
  • The cytological classifications were compared with histopathological findings in bile ducts from explanted livers or clinical outcome.
  • RESULTS: Among patients with cytological low-grade (n=9; 15%) or high-grade dysplasia/adenocarcinoma (n=13; 21%), 8 (36%) proved to have cholangiocarcinoma and 7 (32%) to have high-grade dysplasia (i.e. cholangiocarcinoma in situ) in bile ducts from explanted livers.
  • The sensitivity, specificity, positive- and negative predictive values, and accuracy of brush cytology in diagnosis of biliary malignancy were 100%, 84%, 68%, 100%, and 88% for the combination of low-grade and high-grade dysplasia/adenocarcinoma and 73%, 95%, 85%, 91%, and 90% for high-grade dysplasia/adenocarcinoma only.
  • All patients with high-grade biliary epithelial dysplasia in explanted bile ducts were tumour free at follow-up.
  • CONCLUSIONS: Brush cytology from bile duct strictures in PSC patients can detect cholangiocarcinoma in situ.
  • Patients with cytological low-grade and high-grade dysplasia/adenocarcinoma are currently referred for liver transplantation in our hospital.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Biopsy / methods. Cholangiocarcinoma / pathology. Cholangitis, Sclerosing / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adolescent. Adult. Aged. Biomarkers, Tumor. Carcinoma in Situ / pathology. Cholangiopancreatography, Endoscopic Retrograde. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Prospective Studies. Sensitivity and Specificity

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  • [CommentIn] J Hepatol. 2006 Oct;45(4):476-9 [16901574.001]
  • (PMID = 16879890.001).
  • [ISSN] 0168-8278
  • [Journal-full-title] Journal of hepatology
  • [ISO-abbreviation] J. Hepatol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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42. Buc E, Lesurtel M, Belghiti J: Is preoperative histological diagnosis necessary before referral to major surgery for cholangiocarcinoma? HPB (Oxford); 2008;10(2):98-105

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Is preoperative histological diagnosis necessary before referral to major surgery for cholangiocarcinoma?
  • When imaging techniques fail to establish the accurate diagnosis, biopsy of the lesion is unavoidable.
  • However, biopsy is not necessarily required for topography of the cholangiocarcinoma (intrahepatic or extrahepatic).
  • Provided that between 8% and 43% of bile duct strictures are not ECC, the lesions mimicking ECC that should be ruled out are gallbladder cancer, Mirizzi syndrome, primary sclerosing cholangitis (PSC), autoimmune pancreatitis and portal biliopathy.
  • Systematic biopsy is usually difficult and has poor sensitivity, but a good knowledge of these mimicking ECC diseases, along with precise analysis of clinical and imaging semiology, may lead to a correct diagnosis without the need for biopsy.
  • 2) Intrahepatic cholangiocarcinoma (ICC) developing in normal liver appears as a hypovascular tumour with fibrotic component and capsular retraction that can be confused with fibrous metastases such as breast and colorectal cancers.
  • The lack of the primary site, a relatively large tumour size and ancillary findings such as bile duct dilatation may provide a clue to the diagnosis.
  • If not, we advocate local resection with lymph node dissection, since ICC is the most likely diagnosis and surgery is the only curative treatment.
  • In the event of adenocarcinoma from unknown primary, surgery is an effective treatment even if prognosis is poor.

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  • (PMID = 18773064.001).
  • [ISSN] 1365-182X
  • [Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association
  • [ISO-abbreviation] HPB (Oxford)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2504385
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43. Kawate S, Ohwada S, Ikota H, Hamada K, Kashiwabara K, Morishita Y: Xanthogranulomatous cholangitis causing obstructive jaundice: a case report. World J Gastroenterol; 2006 Jul 21;12(27):4428-30

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Microscopically, the bile duct was surrounded and narrowed by a xanthogranulomatous lesion, but no xanthogranulomatous cholecystitis was seen.
  • Although percutaneous cholangiograms done via the transhepatic biliary drainage showed smooth narrowing of the upper to middle bile duct, the cytology of bile was diagnosed as class V adenocarcinoma.
  • Therefore, right extended hepatectomy and extrahepatic bile duct resection were performed.
  • Xanthogranulomatous cholangitis is one possible diagnosis of a bile duct stricture.
  • Precise review of all the preoperative information is required to make a correct diagnosis.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adult. Bile Duct Neoplasms / diagnosis. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Diagnosis, Differential. Female. Humans

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  • (PMID = 16865792.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4087761
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44. Okabe Y, Kuwaki K, Kawano H, Kaji R, Sugiyama G, Ishida Y, Yasumoto M, Naito Y, Toyonaga A, Tsuruta O, Sata M: Direct cholangioscopy using a double-balloon enteroscope: choledochojejunostomy with intraductal biliary carcinoma. Dig Endosc; 2010 Oct;22(4):319-21
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Abdominal computed tomography revealed marked dilation of the intrahepatic bile duct in the right lobe and an image of a hypervascular tumor.
  • Endoscopic retrograde cholangiography using double-balloon enteroscopy (DBE) showed a filling defect that was localized to the right hepatic bile duct.
  • Furthermore, the scope was able to readily pass through the anastomosed site of the choledochojejunostomy and, therefore, we observed the interior of the bile duct using the same scope.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic. Carcinoma, Papillary / diagnosis

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  • [Copyright] © 2010 The Authors. Digestive Endoscopy © 2010 Japan Gastroenterological Endoscopy Society.
  • (PMID = 21175487.001).
  • [ISSN] 1443-1661
  • [Journal-full-title] Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
  • [ISO-abbreviation] Dig Endosc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Contrast Media
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45. Goodman ZD: Neoplasms of the liver. Mod Pathol; 2007 Feb;20 Suppl 1:S49-60
MedlinePlus Health Information. consumer health - Liver Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cholangiocarcinoma, a primary adenocarcinoma that arises from a bile duct, is second in frequency.
  • Cholangiocarcinoma resembles adenocarcinomas arising in other tissues, so a definitive diagnosis relies on the exclusion of an extrahepatic primary and distinction from benign biliary lesions.
  • [MeSH-minor] Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / diagnosis. Diagnosis, Differential. Female. Humans. Male

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  • (PMID = 17486052.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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46. Ono S, Fumino S, Shimadera S, Iwai N: Long-term outcomes after hepaticojejunostomy for choledochal cyst: a 10- to 27-year follow-up. J Pediatr Surg; 2010 Feb;45(2):376-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Choledochal cyst (CC) is closely associated with anomalous arrangement of the pancreaticobiliary duct, which is considered a high-risk factor for biliary tract malignancy.
  • Early diagnosis and early treatment for CC could lead to a good prognosis.
  • All patients had undergone total resection of the extrahepatic bile duct and hepaticojejunostomy.
  • Dilatation of intrahepatic bile ducts persisted in 6 postoperatively, and in 3, this was still apparent more than 10 years after.
  • A 14-year-old girl died of recurrent common bile duct cancer 2 years after the initial resection of CC with adenocarcinoma.
  • A 26-year-old man with repeated cholangitis owing to multiple intrahepatic bile stones developed cholangiocarcinoma 26 years after the initial resection of CC.
  • Long-term surveillance for the development of malignancy is still essential, especially if there is ongoing dilatation of the intrahepatic bile duct or biliary stones.
  • [MeSH-minor] Adolescent. Adult. Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic / surgery. Biliary Tract Surgical Procedures / methods. Cholangiocarcinoma / surgery. Common Bile Duct / surgery. Dilatation, Pathologic / surgery. Disease-Free Survival. Female. Follow-Up Studies. Humans. Longitudinal Studies. Male. Prognosis. Retrospective Studies. Treatment Outcome

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20152355.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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47. Igami T, Yokoyama Y, Nishio H, Ebata T, Shimoyama Y, Nakamura S, Nagino M: Small pancreatic carcinoma misdiagnosed as superficially spreading cholangiocarcinoma. J Hepatobiliary Pancreat Surg; 2009;16(4):579-84
MedlinePlus Health Information. consumer health - Pancreatic Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • He was referred to our hospital with a diagnosis of superficially spreading cholangiocarcinoma.
  • Cholangiography revealed a stenosis of the common bile duct, and also revealed some irregularities from the common hepatic duct to the left hepatic duct, suggesting a superficial spread of cancer.
  • Cholangioscopy disclosed an elevated tumor with torsional vessels and granular mucosal lesions, which were extended to the left hepatic duct.
  • Repeated cholangioscopic biopsies of the bile duct mucosa revealed adenocarcinoma.
  • The patient was diagnosed with superficially spreading cholangiocarcinoma extending to the left hepatic duct and the right anterior hepatic duct.
  • Histological findings of the resected specimen revealed adenocarcinoma arising from the pancreatic head with invasion in the common bile duct.
  • Additionally, extensive inflammatory granulation tissue was observed along the surface of the bile duct, without any evidence of carcinoma.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic. Cholangiocarcinoma / diagnosis. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Aged. Common Bile Duct Neoplasms / diagnosis. Humans. Male

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  • (PMID = 19259611.001).
  • [ISSN] 1436-0691
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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48. Dumitrascu T, Ionescu M, Ciurea S, Herlea V, Lupescu I, Popescu I: Klatskin-mimicking lesions--a case series and literature review. Hepatogastroenterology; 2010 Jul-Aug;57(101):961-7
MedlinePlus Health Information. consumer health - Bile Duct Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Obstruction of the hepatic hilum in patients without prior surgery is generally due to hilar adenocarcinoma (Klatskin tumor).
  • Although uncommon, benign strictures of the proximal bile duct should be taken into consideration in differential diagnosis of Klatskin tumors, since the incidence could reach up to 25% of patients with presumed Klatskin tumor diagnosis.
  • This group of benign proximal bile duct strictures (Klatskin-mimicking lesions) is usually represented by segmental fibrosis and non-specific chronic inflammation.
  • Herein, we present a case series of three patients with benign proximal bile duct strictures (representing 4.1% of 73 patients resected with presumptive preoperative diagnosis of Klatskin tumor) and literature review.
  • However, despite new diagnosis tools developed in the last years, patients with hilar obstructions still require unnecessary extensive resections due to impossibility of excluding the malignancy.
  • In all cases of proximal bile duct obstruction presumed malignant, they should be managed accordingly, even with the risk of over-treatment for some benign lesions.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Hepatic Duct, Common. Klatskin Tumor / diagnosis
  • [MeSH-minor] Adult. Bile Ducts, Intrahepatic / pathology. Cholangiopancreatography, Endoscopic Retrograde. Cholangiopancreatography, Magnetic Resonance. Cholestasis. Diagnosis, Differential. Dilatation, Pathologic. Humans. Magnetic Resonance Imaging. Male. Middle Aged

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  • (PMID = 21033260.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Greece
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49. Onodera S, Saito K, Saito T, Togashi H, Kawata S, Ukai K, Shinzawa H: [Clonorchiasis complicated with duodenal papillary cancer in a visitor from China]. Nihon Shokakibyo Gakkai Zasshi; 2007 Feb;104(2):213-8
MedlinePlus Health Information. consumer health - Intestinal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It is well known that long-term infection with Clonorchis sinensis often causes bile duct cancer, usually.
  • It occurs in the intrahepatic bile duct.
  • Also, we reported that the microplate ELISA technique was useful in the diagnosis of clonorchiasis with high accuracy in this case.
  • [MeSH-major] Adenocarcinoma / etiology. Ampulla of Vater. Clonorchiasis / complications. Common Bile Duct Neoplasms / etiology. Duodenal Neoplasms / etiology

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  • (PMID = 17283416.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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50. Lee BK, Seo YH, Lee NH, Joo SY, Ko HM: [Cholangiocarcinoma with distant cutaneous metastases]. Korean J Gastroenterol; 2009 Nov;54(5):342-5
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cholangiocarcinoma, a malignant cancer of the bile duct, is a relatively rare adenocarcinoma and has a poor prognosis.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic. Cholangiocarcinoma / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 19934617.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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51. Artifon EL, Rodrigues AZ, Marques S, Halwan B, Sakai P, Bresciani C, Kumar A: Laparoscopic deployment of biliary self-expandable metal stent (SEMS) for one-step palliation in 23 patients with advanced pancreatico-biliary tumors--a pilot trial. J Gastrointest Surg; 2007 Dec;11(12):1686-91
MedlinePlus Health Information. consumer health - Pancreatic Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Exploratory laparoscopy is commonly undertaken in patients with highly suspicious biliary and pancreatic lesions to facilitate diagnosis and staging cancer is present.
  • PATIENTS AND METHODS: A total of 23 eligible patients (8 male and 15 female) with malignant obstruction of the common bile duct underwent deployment of SEMS at laparoscopy.
  • RESULTS: Indications for stent deployment were unresectable pancreatic cancer in 18, cholangiocarcinoma in two, neuroendocrine tumor in one and ampullary adenocarcinoma in two patients.
  • The median size of the pancreatic mass was 3 cm (range 2-5 cm) and that of the common bile duct (CBD) from 9.2 mm (range 7.2-17.4).
  • CONCLUSION: This study demonstrates that laparoscopic deployment of self-expandable metal bile duct stents is feasible and safe.
  • This option appears to be a reasonable option in patients with inoperable malignant obstruction of the distal common bile duct.
  • [MeSH-major] Adenocarcinoma / surgery. Biliary Tract Neoplasms / surgery. Palliative Care. Pancreatic Neoplasms / surgery. Stents
  • [MeSH-minor] Aged. Aged, 80 and over. Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic / surgery. Cholangiocarcinoma / surgery. Feasibility Studies. Female. Fluoroscopy. Humans. Laparoscopy. Male. Middle Aged. Pilot Projects. Prosthesis Design

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  • (PMID = 17906909.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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52. Hiraki S, Matsukuma S, Nagashima A, Kawaoka T, Fukuda S: [A case of cholangiocellular carcinoma accompanied with peripheral blood eosinophilia which improved by removal of the hepatic tumor]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2801-3
MedlinePlus Health Information. consumer health - Eosinophilic Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Needle biopsy of the hepatic tumor revealed an adenocarcinoma.
  • We performed left hepatectomy with lymph node dissection without a bile duct reconstruction.
  • The tumor was mass forming type accompanied with intra bile ductal growth in macroscopically.
  • Pathological diagnosis was cholangiocellular carcinoma.
  • [MeSH-major] Bile Duct Neoplasms / complications. Bile Ducts, Intrahepatic. Cholangiocarcinoma / complications. Eosinophilia / etiology

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  • (PMID = 21224718.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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53. Nuernberg D, Ignee A, Dietrich CF: [Ultrasound in gastroenterology. Biliopancreatic system]. Med Klin (Munich); 2007 Feb 15;102(2):112-26
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  • GALLBLADDER: Ultrasound has become widely accepted for the diagnosis of gallbladder disease.
  • An obstruction of the bile ducts and its localization are easily recognized.
  • BILE DUCT SYSTEM: Even with the most modern equipment the sensitivity for choledocholithiasis is still largely dependent on the examiner's expertise und differs between 25% and 100%.
  • Primary sclerosing cholangitis shows bile duct dilation like "a string of pearls" and typical perihepatic lymph node enlargement.
  • Ductal adenocarcinoma seems to be less vascularized in comparison to the surrounding tissue, while endocrine tumors and macro- and microcystic adenoma are rather hypervascularized.
  • [MeSH-minor] Adenoma / ultrasonography. Bile Duct Neoplasms / ultrasonography. Bile Ducts, Intrahepatic / ultrasonography. Carcinoma / ultrasonography. Cholangiocarcinoma / ultrasonography. Cholangitis, Sclerosing / ultrasonography. Cholecystitis / ultrasonography. Choledocholithiasis / ultrasonography. Contrast Media. Diagnosis, Differential. Endosonography. Gallbladder Neoplasms / ultrasonography. Humans. Middle Aged. Pancreatic Neoplasms / ultrasonography. Pancreatitis / ultrasonography. Polyps / ultrasonography. Sensitivity and Specificity. Ultrasonography, Doppler, Color / methods

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  • (PMID = 17323018.001).
  • [ISSN] 0723-5003
  • [Journal-full-title] Medizinische Klinik (Munich, Germany : 1983)
  • [ISO-abbreviation] Med. Klin. (Munich)
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 228
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54. Itatsu K, Fujii T, Sasaki M, Zen Y, Nakanuma Y: Intraductal papillary cholangiocarcinoma and atypical biliary epithelial lesions confused with intrabiliary extension of metastatic colorectal carcinoma. Hepatogastroenterology; 2007 Apr-May;54(75):677-80
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  • The first case (65-year-old female) presented intrahepatic papillary adenocarcinoma with intrabiliary extension.
  • Finally, a diagnosis of intraductal papillary cholangiocarcinoma of oncocytic variant was made.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Duct Neoplasms / secondary. Carcinoma / secondary. Cholangiocarcinoma / pathology. Colorectal Neoplasms / pathology. Neoplasms, Multiple Primary / pathology
  • [MeSH-minor] Aged. Bile Ducts, Intrahepatic / pathology. Diagnosis, Differential. Female. Humans. Keratin-20 / analysis. Keratin-7 / analysis. Male. Middle Aged

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  • (PMID = 17591040.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Keratin-20; 0 / Keratin-7
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55. Saikusa N, Naito S, Iinuma Y, Ohtani T, Yokoyama N, Nitta K: Invasive cholangiocarcinoma identified in congenital biliary dilatation in a 3-year-old boy. J Pediatr Surg; 2009 Nov;44(11):2202-5
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  • Computed tomography and magnetic resonance imaging demonstrated a dilated extrahepatic bile duct.
  • A diagnosis of Todani's type 1a CBD was made.
  • Intraoperative cholangiography demonstrated the presence of pancreaticobiliary maljunction but could not reveal any tumor lesion in the bile duct.
  • The excision of extrahepatic bile duct and gallbladder and Roux-en-Y hepaticojejunostomy were performed.
  • However, the postoperative histopathologic examinations confirmed the presence of well-differentiated tubular adenocarcinoma with lymphovascular invasion.
  • Most of the carcinoma remained within the mucosal layer, and the carcinoma was identified at both the distal and proximal surgical margins of the bile duct.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Duct Neoplasms / surgery. Cholangiocarcinoma / pathology. Cholangiocarcinoma / surgery. Common Bile Duct / pathology. Common Bile Duct / surgery. Dilatation, Pathologic / congenital. Dilatation, Pathologic / surgery
  • [MeSH-minor] Age Factors. Anastomosis, Roux-en-Y / methods. Bile Ducts, Extrahepatic / radiography. Bile Ducts, Extrahepatic / surgery. Bile Ducts, Intrahepatic / pathology. Bile Ducts, Intrahepatic / surgery. Biliary Tract Surgical Procedures / methods. Child, Preschool. Cholangiography. Humans. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness / radiography. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19944233.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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56. Nakano H, Yamamura T, Yamaguchi S, Otsubo T: Celiac axis occlusion of a patient undergoing pancreaticoduodenectomy after distal gastrectomy. Hepatogastroenterology; 2007 Mar;54(74):595-8
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  • Celiac axis occlusion does not recently seem an uncommon finding in cases of pancreaticoduodenectomy but diagnosis of celiac axis occlusion may be difficult in patients with former abdominal surgery.
  • The present case report shows a patient with pancreatic head adenocarcinoma, in whom a preoperative diagnosis of celiac axis occlusion was not proved because of displacement of the celiomesenteric arterial branches based on former distal gastrectomy with Kocher's maneuver.
  • A 56-year-old man with malignant obstruction of the lower bile duct was referred to our hospital for undergoing pancreaticoduodenectomy.
  • In cases of pancreaticoduodenectomy, careful preoperative angiographic diagnosis is needed for patients with celiac axis occlusion who have undergone former gastric surgery because the celio-mesenteric arterial branches have been displaced by Kocher's maneuver.
  • [MeSH-major] Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic / surgery. Carcinoma, Pancreatic Ductal / surgery. Celiac Artery / surgery. Cholangiocarcinoma / surgery. Gastrectomy. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy. Postoperative Complications / surgery. Stomach Ulcer / surgery
  • [MeSH-minor] Aged. Aortography. Cholangiopancreatography, Endoscopic Retrograde. Constriction, Pathologic / diagnosis. Constriction, Pathologic / surgery. Diagnosis, Differential. Hepatectomy. Humans. Ligaments / surgery. Liver / blood supply. Middle Aged. Reoperation. Tomography, X-Ray Computed

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  • (PMID = 17523329.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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57. Kumar S, Masood N, Shaikh AJ, Valimuhammad AT, Haider G, Lal A, Niamatullah N: Clinical presentation and outcomes of patients with biliary malignancies: the Aga Khan University experience. Asian Pac J Cancer Prev; 2009 Jul-Sep;10(3):463-6
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  • RESULTS: A total of 245 patients were admitted with diagnosis of GBC or cholangiocarcinoma.
  • Pathological diagnosis was confirmed in 155 (63.2%) patients, adenocarcinoma (94.8%) being the predominant type.
  • Common bile duct stricture was seen in 78 patients and stenting was successful in 73 patients.
  • Fourteen (5.7%) patients are alive to date, one is receiving chemotherapy, and another is alive with advanced disease while 10 patients had incidental diagnosis after surgery.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bile Duct Neoplasms / drug therapy. Bile Ducts, Intrahepatic / drug effects. Cholangiocarcinoma / drug therapy. Gallbladder Neoplasms / drug therapy. Liver Neoplasms / drug therapy

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  • (PMID = 19640192.001).
  • [ISSN] 2476-762X
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; B76N6SBZ8R / gemcitabine; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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58. Larghi A, Lecca PG, Ardito F, Rossi ED, Fadda G, Nuzzo G, Costamagna G: Evaluation of hilar biliary strictures by using a newly developed forward-viewing therapeutic echoendoscope: preliminary results of an ongoing experience. Gastrointest Endosc; 2009 Feb;69(2):356-60

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  • BACKGROUND: Obtaining a definitive tissue diagnosis in patients with hilar biliary strictures (HBS) is often difficult.
  • RESULTS: Visualization and puncture of the primary lesion with a definitive tissue diagnosis was obtained in all of the 4 cases performed.
  • In the other 2 patients, a diagnosis of resectable hilar cholangiocarcinoma and poorly differentiated adenocarcinoma of unclear origin without evidence of vascular involvement was made, and plastic stents were placed before surgery; the first patient was found to have peritoneal metastases, and resection was aborted, and in the second patient, a gallbladder tumor was diagnosed in the surgical specimen.
  • [MeSH-major] Cholestasis, Intrahepatic / diagnosis. Endosonography / methods
  • [MeSH-minor] Adenocarcinoma / diagnosis. Aged. Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic. Biopsy, Fine-Needle. Cholangiocarcinoma / diagnosis. Female. Humans. Male. Middle Aged. Stents

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  • (PMID = 19185697.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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59. Barinagarrementeria R: [Update on endoscopic management of malignant obstructive jaundice]. Rev Gastroenterol Mex; 2005 Jul;70 Suppl 1:95-106
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  • The diagnosis of bilio-pancreatic diseases is carried out when patients present symptoms of biliary obstruction.
  • The majority of these patients cannot receive curative treatment at the time of the diagnosis.
  • [MeSH-major] Adenocarcinoma / complications. Ampulla of Vater. Bile Duct Neoplasms / complications. Bile Ducts, Intrahepatic. Cholangiocarcinoma / complications. Cholangiopancreatography, Endoscopic Retrograde. Cholangiopancreatography, Magnetic Resonance. Common Bile Duct Neoplasms / complications. Jaundice, Obstructive / etiology. Pancreatic Neoplasms / complications
  • [MeSH-minor] Cholangiography. Cholestasis, Extrahepatic / diagnosis. Cholestasis, Intrahepatic / diagnosis. Common Bile Duct / pathology. Diagnosis, Differential. Endosonography. Humans. Neoplasm Staging. Palliative Care. Pancreas / pathology. Tomography, Spiral Computed

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  • (PMID = 17469413.001).
  • [ISSN] 0375-0906
  • [Journal-full-title] Revista de gastroenterología de México
  • [ISO-abbreviation] Rev Gastroenterol Mex
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Mexico
  • [Number-of-references] 101
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60. Zong GQ, Liu XS, Wang F, Gong CH: [Surgical treatment result of hilar cholangiocarcinoma: report of 84 patients]. Zhonghua Zhong Liu Za Zhi; 2007 Apr;29(4):312-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To analyze the surgical treatment result and clinical characteristics of hilar cholangiocarcinoma in order to improve the rate of early diagnosis and radical resection.
  • 32 patients (38.1%) had had the history of operation for cholelithiasis before or were found to have cholelithiasis simultaneously at the time of diagnosis.
  • The rate of making correct diagnosis by ultrasound, CT and MRCP was 71.4% , 84.0% and 91.4% , respectively.
  • Early diagnosis and radical resection are two important factors to improve the prognosis of hilar cholangiocarcinoma.
  • [MeSH-major] Adenocarcinoma / surgery. Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic. Biliary Tract Surgical Procedures / methods. Cholangiocarcinoma / surgery
  • [MeSH-minor] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / surgery. Adult. Aged. Aged, 80 and over. Drainage / methods. Female. Humans. Male. Middle Aged. Retrospective Studies. Survival Analysis

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  • (PMID = 17760264.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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61. Mosconi S, Beretta GD, Labianca R, Zampino MG, Gatta G, Heinemann V: Cholangiocarcinoma. Crit Rev Oncol Hematol; 2009 Mar;69(3):259-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cholangiocarcinoma is an uncommon adenocarcinoma with poor prognosis.
  • Patients' prognosis is strongly related to radical surgery and complete resection is the most effective therapy; the location within the biliary tree (proximal versus distal) has no impact on survival when a complete resection is achieved despite the fact the rate of resectability is up to 70% in case of distal cancer and 15-20% for high bile ducts tumours.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Bile Duct Neoplasms / therapy. Cholangiocarcinoma / diagnosis. Cholangiocarcinoma / therapy
  • [MeSH-minor] Bile Ducts, Intrahepatic / pathology. Humans. Liver Transplantation. Neoplasm Staging. Risk Factors

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  • (PMID = 18977670.001).
  • [ISSN] 1879-0461
  • [Journal-full-title] Critical reviews in oncology/hematology
  • [ISO-abbreviation] Crit. Rev. Oncol. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 79
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62. Valls C: [Obstructive Jaundice: diagnostic and therapeutic management]. J Radiol; 2006 Apr;87(4 Pt 2):460-78
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The purpose of this article is to provide an update on imaging techniques for diagnosis and staging of clinical conditions leading to obstructive jaundice.
  • Imaging and treatment strategies will be discussed in order to provide an optimal diagnosis and staging with the least invasive techniques in order to minimize complications in these patients.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Jaundice, Obstructive / diagnosis. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / radiography. Adenocarcinoma / surgery. Aged. Ampulla of Vater. Bile Ducts, Intrahepatic. Cholangiocarcinoma / diagnosis. Cholangiocarcinoma / radiography. Cholangiopancreatography, Magnetic Resonance. Common Bile Duct Neoplasms / diagnosis. Common Bile Duct Neoplasms / radiography. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Metastasis. Pancreas / abnormalities. Pancreatic Pseudocyst / diagnosis. Pancreatic Pseudocyst / radiography. Pancreatitis, Chronic / diagnosis. Pancreatitis, Chronic / radiography. Risk Factors. Tomography, X-Ray Computed

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  • (PMID = 16691176.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 44
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63. Sadhu A, Sen S, Seal S, Sharma SK: Metastasis--an unusual cause of retroperitoneal fibrosis. J Indian Med Assoc; 2006 Nov;104(11):642, 644
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  • Ultrasonography showed dilated intrahepatic bilary radicles and mild ascites.
  • Contrast CT-scan showed enhancing sheath of soft tissue extending from porta down to aortic bifurcation encasing common bile duct, aorta, inferior vena cava and the ureters.
  • CT-guided fine needle aspiration cytology revealed metastatic adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Retroperitoneal Fibrosis / diagnosis. Retroperitoneal Neoplasms / pathology

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  • (PMID = 17444067.001).
  • [ISSN] 0019-5847
  • [Journal-full-title] Journal of the Indian Medical Association
  • [ISO-abbreviation] J Indian Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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64. Brown KM: Multidisciplinary approach to tumors of the pancreas and biliary tree. Surg Clin North Am; 2009 Feb;89(1):115-31, ix
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenocarcinoma / therapy. Algorithms. Bile Duct Neoplasms / diagnosis. Bile Duct Neoplasms / therapy. Bile Ducts, Intrahepatic. Carcinoma, Pancreatic Ductal / therapy. Cholangiocarcinoma / diagnosis. Cholangiocarcinoma / therapy. Diagnostic Imaging. Endosonography. Humans. Pancreatectomy. Positron-Emission Tomography. Radiology, Interventional

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  • (PMID = 19186234.001).
  • [ISSN] 0039-6109
  • [Journal-full-title] The Surgical clinics of North America
  • [ISO-abbreviation] Surg. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 77
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65. Ushiku T, Shinozaki A, Shibahara J, Iwasaki Y, Tateishi Y, Funata N, Fukayama M: SALL4 represents fetal gut differentiation of gastric cancer, and is diagnostically useful in distinguishing hepatoid gastric carcinoma from hepatocellular carcinoma. Am J Surg Pathol; 2010 Apr;34(4):533-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Hepatocellular / diagnosis. Hepatoblastoma / diagnosis. Liver Neoplasms / diagnosis. Stomach Neoplasms / diagnosis. Transcription Factors / metabolism
  • [MeSH-minor] Aged. Bile Duct Neoplasms / diagnosis. Bile Duct Neoplasms / metabolism. Bile Ducts, Intrahepatic / pathology. Biomarkers, Tumor / metabolism. Cholangiocarcinoma / diagnosis. Cholangiocarcinoma / metabolism. Diagnosis, Differential. Female. Fetus / embryology. Fetus / metabolism. Gestational Age. Glypicans / metabolism. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Stomach / embryology. Stomach / metabolism. Tissue Array Analysis. alpha-Fetoproteins / metabolism

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  • (PMID = 20182341.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glypicans; 0 / SALL4 protein, human; 0 / Transcription Factors; 0 / alpha-Fetoproteins
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66. Gu MJ, Choi JH, Park WK, Chang JC, Kim HJ: [Primary adenosquamous carcinoma of the liver: a case report]. Korean J Hepatol; 2005 Mar;11(1):86-9
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  • Abdominal computed tomography scan revealed a low density mass and intrahepatic duct stones within the dilated left intrahepatic duct in the left lateral segment.
  • Needle biopsy of the mass was done and the histologic diagnosis was cholangiocarcinoma.
  • Upon gross examination, there was a well defined solid mass and intrahepatic duct stone in the dilated bile duct.
  • Microscopically, the tumor was composed of both adenocarcinoma and squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Adenosquamous / diagnosis. Liver Neoplasms / diagnosis

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  • (PMID = 15788889.001).
  • [ISSN] 1738-222X
  • [Journal-full-title] The Korean journal of hepatology
  • [ISO-abbreviation] Korean J Hepatol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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67. Zhong L, Li L, Yao QY: Preoperative evaluation of pancreaticobiliary tumor using MR multi-imaging techniques. World J Gastroenterol; 2005 Jun 28;11(24):3756-61
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  • METHODS: MR multi-imaging techniques, including MR cross-sectional imaging, MR cholangiopancreatography (MRCP) and 3D dynamic contrast-enhanced MR angiography (3D DCE MRA), were performed to make prospective diagnosis and preoperative evaluation in 28 patients with suspected pancreaticobiliary tumors.
  • There were 17 cases of pancreatic adenocarcinoma, 8 cases of biliary system carcinoma and 3 cases of non-neoplastic lesions.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / pathology. Cholangiopancreatography, Magnetic Resonance / methods. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Common Bile Duct Neoplasms / pathology. Female. Gallbladder Neoplasms / pathology. Humans. Male. Middle Aged. Preoperative Care. Prospective Studies. Reproducibility of Results. Sensitivity and Specificity

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  • (PMID = 15968734.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4316030
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68. Matsutani T, Uchida E, Yokoyama T, Matsushita A, Matsuda A, Sasajima K: A case of unresectable gallbladder cancer responding to gemcitabine after metallic biliary stent implantation. J Nippon Med Sch; 2009 Oct;76(5):253-7
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  • She underwent exploratory laparotomy under a diagnosis of advanced biliary tract cancer.
  • Histological examination of a biopsy specimen of the gallbladder revealed adenocarcinoma.
  • Retrograde transhepatic bile drainage tubes were inserted through the common bile duct into the right and left branches of the intrahepatic bile ducts.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antimetabolites, Antineoplastic / administration & dosage. Deoxycytidine / analogs & derivatives. Gallbladder Neoplasms / drug therapy. Stents

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  • (PMID = 19915309.001).
  • [ISSN] 1345-4676
  • [Journal-full-title] Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
  • [ISO-abbreviation] J Nippon Med Sch
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Metals; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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69. Stavropoulos S, Larghi A, Verna E, Battezzati P, Stevens P: Intraductal ultrasound for the evaluation of patients with biliary strictures and no abdominal mass on computed tomography. Endoscopy; 2005 Aug;37(8):715-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histopathological confirmation or clinical follow-up was used to establish the final diagnosis.
  • [MeSH-major] Bile Ducts / pathology. Bile Ducts / ultrasonography. Endosonography
  • [MeSH-minor] Adenocarcinoma / complications. Adult. Aged. Aged, 80 and over. Bile Duct Neoplasms / complications. Bile Ducts, Intrahepatic. Cholangiocarcinoma / complications. Cholangiopancreatography, Endoscopic Retrograde. Constriction, Pathologic. Humans. Male. Middle Aged. Pancreatic Neoplasms / complications. Sensitivity and Specificity

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  • (PMID = 16032489.001).
  • [ISSN] 0013-726X
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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70. Lefevre JH, Svrcek M, Frileux P, Paye F: [Intrabiliary metastasis in colorectal cancer]. Gastroenterol Clin Biol; 2007 Feb;31(2):146-8
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ultra-sound, CTscan, RMI and PET led to the diagnosis of endobiliary metastasis and the patient underwent a right hepatectomy.
  • These tumours can mimic intrahepatic cholangiocarcinoma in clinical presentation, imaging or even histological examinations.
  • Patients with endobiliary metastasis seem to have better survival than patients with intrahepatic metastasis.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Bile Duct Neoplasms / secondary. Colorectal Neoplasms / pathology

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  • MedlinePlus Health Information. consumer health - Bile Duct Cancer.
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  • (PMID = 17347621.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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71. Magerl C, Ellinger J, Braunschweig T, Kremmer E, Koch LK, Höller T, Büttner R, Lüscher B, Gütgemann I: H3K4 dimethylation in hepatocellular carcinoma is rare compared with other hepatobiliary and gastrointestinal carcinomas and correlates with expression of the methylase Ash2 and the demethylase LSD1. Hum Pathol; 2010 Feb;41(2):181-9
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • High levels of H3K4diMe were rarely observed in 15.7% of hepatocellular carcinoma (8/51) unlike other carcinomas including, in ascending order, cholangiocellular carcinoma/adenocarcinoma of the extrahepatic biliary tract, gastric carcinoma, pancreatic ductal adenocarcinoma, and neuroendocrine carcinoma (P < .001).
  • In summary, high H3K4diMe expression is rare in hepatocellular carcinoma compared with other carcinomas (negative predictive value 92.3%), which may aid in the differential diagnosis.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Bile Duct Neoplasms / genetics. Bile Duct Neoplasms / metabolism. Bile Ducts, Extrahepatic / metabolism. Bile Ducts, Intrahepatic / metabolism. Chi-Square Distribution. Cholangiocarcinoma / genetics. Cholangiocarcinoma / metabolism. Female. Gastrointestinal Neoplasms / genetics. Gastrointestinal Neoplasms / metabolism. Humans. Immunohistochemistry. Lysine / genetics. Lysine / metabolism. Male. Methylation. Middle Aged. Pancreatic Neoplasms / genetics. Pancreatic Neoplasms / metabolism

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19896696.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ASH2L protein, human; 0 / DNA-Binding Proteins; 0 / Histones; 0 / Nuclear Proteins; 0 / Transcription Factors; EC 1.14.11.- / Histone Demethylases; EC 1.5.- / KDM1A protein, human; K3Z4F929H6 / Lysine
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72. Alberts SR, Gores GJ, Kim GP, Roberts LR, Kendrick ML, Rosen CB, Chari ST, Martenson JA: Treatment options for hepatobiliary and pancreatic cancer. Mayo Clin Proc; 2007 May;82(5):628-37
Hazardous Substances Data Bank. ETHANOL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This review provides an updated summary of diagnosis and assessment together with treatment options for this group of cancers.
  • [MeSH-major] Adenocarcinoma / therapy. Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic. Cholangiocarcinoma / surgery. Liver Neoplasms / surgery. Liver Transplantation. Pancreatic Neoplasms / therapy


73. Khunamornpong S, Suprasert P, Chiangmai WN, Siriaunkgul S: Metastatic tumors to the ovaries: a study of 170 cases in northern Thailand. Int J Gynecol Cancer; 2006 Jan-Feb;16 Suppl 1:132-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The medical records, the radiologic findings, and the follow-up outcome in the cases suspicious or diagnostic of metastases were reviewed to confirm the diagnosis and to determine the primary sites.
  • Nongynecologic metastatic tumors were from large intestine (31%), stomach (14%), intrahepatic bile duct (10%), breast (9%), extrahepatic bile duct/gallbladder (7%), appendix (5%), hematologic tumors (3%), others (4%), and unknown primary site (16%).
  • [MeSH-major] Adenocarcinoma, Mucinous / epidemiology. Ovarian Neoplasms / epidemiology

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  • (PMID = 16515581.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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74. Costa DB, Stuart KE, Inzucchi SE: Hyperglycemia and biliary tract adenocarcinoma. J Gastroenterol Hepatol; 2006 Feb;21(2):484-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hyperglycemia and biliary tract adenocarcinoma.
  • [MeSH-major] Bile Duct Neoplasms / complications. Bile Ducts, Intrahepatic. Biliary Tract Neoplasms / complications. Cholangiocarcinoma / complications. Hyperglycemia / complications
  • [MeSH-minor] Adult. Aged. Blood Glucose / metabolism. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Risk Factors

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  • (PMID = 16509886.001).
  • [ISSN] 0815-9319
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Letter
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Blood Glucose
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75. Han JK, Kim SH, Kim SJ: [Intraductal papillary mucinous cholangiocarcinoma]. Korean J Hepatol; 2007 Jun;13(2):243-7
MedlinePlus Health Information. consumer health - Bile Duct Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic. Carcinoma, Papillary / diagnosis. Cholangiocarcinoma / diagnosis

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  • (PMID = 17585199.001).
  • [ISSN] 1738-222X
  • [Journal-full-title] The Korean journal of hepatology
  • [ISO-abbreviation] Korean J Hepatol
  • [Language] kor
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
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76. Diehl DL: Use of a 22-mm enteral Wallstent for biliary obstruction. Gastrointest Endosc; 2006 Dec;64(6):1003-4; discussion 1004
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma / complications. Bile Duct Neoplasms / complications. Bile Ducts, Intrahepatic. Cholangiopancreatography, Endoscopic Retrograde. Cholestasis, Intrahepatic / surgery. Prosthesis Implantation / methods. Stents
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Fatal Outcome. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 17140914.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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