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1. Nakanuma Y, Sasaki M, Sato Y, Ren X, Ikeda H, Harada K: Multistep carcinogenesis of perihilar cholangiocarcinoma arising in the intrahepatic large bile ducts. World J Hepatol; 2009 Oct 31;1(1):35-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multistep carcinogenesis of perihilar cholangiocarcinoma arising in the intrahepatic large bile ducts.
  • Flat-type "biliary intraepithelial neoplasia (BilIN)" and papillary-type "intraductal papillary neoplasm of the bile duct (IPN-B)" are proposed as precursors of invasive, perihilar intrahepatic cholangiocarcinoma (ICC).
  • Three carcinogenetic pathways are proposed: BilIN progressing to tubular adenocarcinoma, and IPN-B progressing to tubular adenocarcinoma or to colloid carcinoma.
  • Carcinogenesis via BilIN was characterized by mucin core protein 2-/cytokeratin 20-(MUC2-/CK20-) with MUC1 expression, while carcinogenesis via IPN-B leading to tubular adenocarcinoma was associated with MUC1 expression or that to colloid carcinoma with MUC1-negativity.


2. Zen Y, Fujii T, Itatsu K, Nakamura K, Konishi F, Masuda S, Mitsui T, Asada Y, Miura S, Miyayama S, Uehara T, Katsuyama T, Ohta T, Minato H, Nakanuma Y: Biliary cystic tumors with bile duct communication: a cystic variant of intraductal papillary neoplasm of the bile duct. Mod Pathol; 2006 Sep;19(9):1243-54
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  • [Title] Biliary cystic tumors with bile duct communication: a cystic variant of intraductal papillary neoplasm of the bile duct.
  • Biliary cystic tumors, which are also called biliary cystadenoma and cystadenocarcinoma, are thought to be a heterogeneous disease entity, and some of them are known to show a luminal communication to the bile duct.
  • In this study, we examined the clinicopathological features of nine cases of biliary cystic tumors with bile duct communication.
  • A direct luminal communication with the bile ducts was identified in five cases on preoperative or intraoperative cholangiographies.
  • Biliary cystic tumors examined in this study were histologically adenoma (one case), adenocarcinoma in situ (six cases), and adenocarcinoma associated with microinvasive mucinous carcinoma (two cases).
  • One case of adenocarcinoma in situ also had the adenoma component (adenocarcinoma in adenoma).
  • Intraepithelial neoplasm was observed within non-dilated adjacent bile ducts, suggesting a direct luminal communication between the cystic tumors and the bile duct.
  • These clinicopathological features resembled those of intraductal papillary neoplasm of the bile duct, which had been reported as a biliary counterpart of pancreatic intraductal papillary mucinous neoplasm.
  • In conclusion, biliary cystic tumors with bile duct communication could be regarded as intraductal papillary neoplasm with a prominent cystic dilatation of the bile duct and mucin retention, rather than true biliary cystic neoplasms.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / pathology. Cystadenocarcinoma / pathology. Cystadenoma / pathology

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  • [Copyright] Published online 2 June 2006.
  • (PMID = 16741522.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Homeodomain Proteins; 0 / MUC2 protein, human; 0 / Mucin-1; 0 / Mucin-2; 0 / Mucins; 0 / Trans-Activators; 156560-97-3 / Cdx-2-3 protein
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3. Joo HJ, Kim GH, Jeon WJ, Chae HB, Park SM, Youn SJ, Choi JW, Sung R: Metachronous bile duct cancer nine years after resection of gallbladder cancer. World J Gastroenterol; 2009 Jul 21;15(27):3440-4
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  • [Title] Metachronous bile duct cancer nine years after resection of gallbladder cancer.
  • We report a rare case of a 74-year-old man with metachronous gallbladder cancer and bile duct cancer who underwent curative resection twice, with the operations nine years apart.
  • This was a well-differentiated adenocarcinoma, with negative resection margins (T2N0M0, stage IB).
  • Nine years later, during a follow-up examination, abdominal computed tomography and MRCP showed an enhanced 1.7 cm mass in the hilum that extended to the second branch of the right intrahepatic bile duct.
  • We diagnosed this lesion as a perihilar bile duct cancer, Bismuth type IIIa, and performed bile duct excision, right hepatic lobectomy and Roux-en-Y hepaticojejunostomy.
  • The histological diagnosis was a well-differentiated adenocarcinoma with one regional lymph node metastasis (T1N1M0, stage IIB).
  • [MeSH-major] Adenocarcinoma / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Gallbladder Neoplasms / pathology. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Treatment Outcome. Young Adult

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  • (PMID = 19610150.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2712910
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4. Luke C, Price T, Roder D: Epidemiology of cancer of the liver and intrahepatic bile ducts in an Australian population. Asian Pac J Cancer Prev; 2010;11(6):1479-85
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  • [Title] Epidemiology of cancer of the liver and intrahepatic bile ducts in an Australian population.
  • The incidence of liver and intrahepatic bile duct cancer in Australia is low at about one third the world average but increases are evident.
  • Survival increases may be due to earlier diagnosis from alpha feta protein testing and diagnostic imaging, plus more aggressive treatment of localized disease.
  • [MeSH-major] Adenocarcinoma / epidemiology. Bile Duct Neoplasms / epidemiology. Carcinoma, Hepatocellular / epidemiology. Cholangiocarcinoma / epidemiology. Liver Neoplasms / epidemiology
  • [MeSH-minor] Aged. Aged, 80 and over. Australia / epidemiology. Bile Ducts, Intrahepatic. Female. Humans. Male. Middle Aged. Survival Rate. Treatment Outcome

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  • (PMID = 21338184.001).
  • [ISSN] 2476-762X
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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5. Yokomuro S, Arima Y, Mizuguchi Y, Shimizu T, Kawahigashi Y, Kannda T, Arai M, Uchida E, Akimaru K, Tajiri T: Mucin-producing bile duct carcinoma arising from primary sclerosing cholangitis: a case report. J Nippon Med Sch; 2007 Feb;74(1):61-4
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  • [Title] Mucin-producing bile duct carcinoma arising from primary sclerosing cholangitis: a case report.
  • Imaging studies revealed atypical dilation of bile ducts in the left lobe of the liver.
  • Repeated cytologic examinations of the bile showed atypical cells consistent with adenocarcinoma.
  • The patient underwent extended resection of the left lobe of the liver and was found to have intraductal papillary carcinoma with associated mucin-producing bile duct carcinoma.
  • This carcinoma fills dilated bile duct lumens with mucin.
  • Just one case of mucin-producing bile duct carcinoma arising from PSC has been reported worldwide.
  • Patients with mucin-producing bile duct carcinoma, as in the case of its pancreatic counterpart, may have a better prognosis and a higher survival rate than patients with typical cholangiocarcinomas.
  • [MeSH-major] Adenocarcinoma, Mucinous / surgery. Bile Duct Neoplasms / surgery. Cholangitis, Sclerosing / complications
  • [MeSH-minor] Bile Ducts, Intrahepatic / pathology. Bile Ducts, Intrahepatic / surgery. Female. Humans. Middle Aged. Prognosis

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  • (PMID = 17384480.001).
  • [ISSN] 1345-4676
  • [Journal-full-title] Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
  • [ISO-abbreviation] J Nippon Med Sch
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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6. Tamada S, Shibahara H, Higashi M, Goto M, Batra SK, Imai K, Yonezawa S: MUC4 is a novel prognostic factor of extrahepatic bile duct carcinoma. Clin Cancer Res; 2006 Jul 15;12(14 Pt 1):4257-64
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  • [Title] MUC4 is a novel prognostic factor of extrahepatic bile duct carcinoma.
  • PURPOSE: Many of the patients with extrahepatic bile duct carcinoma (EHBDC) show a poor outcome.
  • We have reported that MUC4 is a novel prognostic factor of pancreatic adenocarcinoma and intrahepatic cholangiocarcinoma.
  • [MeSH-major] Bile Duct Neoplasms / metabolism. Bile Ducts, Extrahepatic / pathology. Carcinoma / metabolism. Gene Expression Regulation, Neoplastic. Mucins / biosynthesis

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  • (PMID = 16857800.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 78590
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MUC4 protein, human; 0 / Mucin-4; 0 / Mucins
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7. Nakanuma Y, Sato Y, Harada K, Sasaki M, Xu J, Ikeda H: Pathological classification of intrahepatic cholangiocarcinoma based on a new concept. World J Hepatol; 2010 Dec 27;2(12):419-27

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pathological classification of intrahepatic cholangiocarcinoma based on a new concept.
  • Intrahepatic cholangiocarcinoma (ICC) arises from the lining epithelium and peribiliary glands of the intrahepatic biliary tree and shows variable cholangiocytic differentiation.
  • To date, ICC was largely classified into adenocarcinoma and rare variants.
  • That is, ICC is classifiable into the conventional (bile duct) type, the bile ductular type, the intraductal neoplasm type and rare variants.
  • The conventional type is further divided into the small duct type (peripheral type) and large bile duct type (perihilar type).
  • The former is a tubular or micropapillary adenocarcinoma while the latter involves the intrahepatic large bile duct.
  • Bile ductular type resembles proliferated bile ductules and shows a replacing growth of the hepatic parenchyma.
  • Hepatic progenitor cell or stem cell phenotypes such as neural cell adhesion molecule expression are frequently expressed in the bile ductular type.
  • Intraductal type includes papillary and tubular neoplasms of the bile duct (IPNBs and ITNBs) and a superficial spreading type.
  • At invasive sites, IPNB is associated with the conventional bile duct ICC and mucinous carcinoma.

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  • (PMID = 21191517.001).
  • [ISSN] 1948-5182
  • [Journal-full-title] World journal of hepatology
  • [ISO-abbreviation] World J Hepatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC3010511
  • [Keywords] NOTNLM ; Adenocarcinoma / Bile duct / Bile ductule / Intraductal neoplasm / Intrahepatic cholangiocarcinoma
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8. Ono S, Sakai K, Kimura O, Iwai N: Development of bile duct cancer in a 26-year-old man after resection of infantile choledochal cyst. J Pediatr Surg; 2008 Jun;43(6):E17-9
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  • [Title] Development of bile duct cancer in a 26-year-old man after resection of infantile choledochal cyst.
  • Anomalous arrangement of the pancreaticobiliary duct is considered to be a high-risk factor for biliary tract malignancy.
  • We report a case of intrahepatic cholangiocarcinoma in a 26-year-old man after total resection of choledochal cyst with anomalous arrangement of the pancreaticobiliary duct at the age of 5 months.
  • Computed tomographic scan and percutaneous transhepatic cholangioscope revealed multiple stones and stenosis of the hepatic duct and the left intrahepatic bile duct.
  • Histologic examination of a biopsy specimen obtained from the stenotic site showed adenocarcinoma of the intrahepatic bile duct.
  • This report warns us that bile stasis owing to stenosis of the intrahepatic bile duct and repeated cholangitis with multiple stones are high-risk factors for carcinogenesis of the intrahepatic bile duct even after total resection of the infantile choledochal cyst.
  • [MeSH-major] Bile Duct Neoplasms / etiology. Bile Ducts, Intrahepatic. Cholangiocarcinoma / etiology. Choledochal Cyst / complications. Choledochal Cyst / surgery. Neoplasm Recurrence, Local / pathology. Precancerous Conditions

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  • (PMID = 18558159.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. Kinjo N, Shimada M, Maeda T, Tanaka S, Shirabe K, Maehara Y: Preoperatively undiagnosable intrahepatic bile duct dilatation contains early-stage intrahepatic cholangiocarcinoma. Hepatogastroenterology; 2005 Sep-Oct;52(65):1368-71
MedlinePlus Health Information. consumer health - Bile Duct Cancer.

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  • [Title] Preoperatively undiagnosable intrahepatic bile duct dilatation contains early-stage intrahepatic cholangiocarcinoma.
  • Intrahepatic bile duct dilatation is a clue to indicating the presence of IHCC.
  • Preoperative imaging studies of these three cases showed the dilatation and stenosis of the intrahepatic bile duct without any apparent mass.
  • As IHCC could not be ruled out, a hepatectomy was done for the purpose of both diagnosis and treatment of the patients.
  • In the case of intrahepatic bile duct dilatation and stenosis, which makes it hard to identify IHCC, surgical resection is crucial to make a definite diagnosis and prescribe the most effective course of treatment.
  • [MeSH-major] Bile Duct Neoplasms / complications. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / complications
  • [MeSH-minor] Abdominal Pain / etiology. Adenocarcinoma / pathology. Cholangiopancreatography, Endoscopic Retrograde. Dilatation, Pathologic. Humans. Liver Neoplasms / pathology. Male. Middle Aged

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  • (PMID = 16201076.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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10. Sano T, Shimada K, Sakamoto Y, Ojima H, Esaki M, Kosuge T: Prognosis of perihilar cholangiocarcinoma: hilar bile duct cancer versus intrahepatic cholangiocarcinoma involving the hepatic hilus. Ann Surg Oncol; 2008 Feb;15(2):590-9
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  • [Title] Prognosis of perihilar cholangiocarcinoma: hilar bile duct cancer versus intrahepatic cholangiocarcinoma involving the hepatic hilus.
  • BACKGROUND: Clinically hepatobiliary resection is indicated for both hilar bile duct cancer (BDC) and intrahepatic cholangiocarcinoma involving the hepatic hilus (CCC).
  • On multivariate analysis, three independent factors were related to longer survival in BDC patients: achieved in curative resection with cancer free margin (R0) (P = .024, odds ratio 1.862), well differentiated or papillary adenocarcinoma (P = .011, odds ratio 2.135), and absence of lymph node metastasis (P < .001, odds ratio 3.314).
  • Five factors were related to longer survival in CCC patients: absence of intrahepatic daughter nodules (P < .001, odds ratio 2.318), CEA level </=2.9 ng/mL (P = .005, odds ratio 2.606), no red blood cell transfusion requirement (P = .016, odds ratio 2.614), absence or slight degree of lymphatic system invasion (P < .001, odds ratio 4.577), and negative margin of the proximal bile duct (P = .003, odds ratio 7.398).
  • [MeSH-major] Bile Duct Neoplasms / mortality. Bile Ducts, Intrahepatic. Cholangiocarcinoma / mortality

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  • (PMID = 18057991.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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11. Bahra M, Langrehr JM, Neuhaus P: [Carcinomas of the distal bile duct]. Chirurg; 2006 Apr;77(4):335-40
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  • [Title] [Carcinomas of the distal bile duct].
  • Malignancies of the biliary tree are classified into three groups according to location: intrahepatic, central (perihilar), and distal.
  • Of all cholangiocarcinomas, 25% are located distally and can be subdivided into middle and lower bile duct carcinomas.
  • Intrahepatic and central cancers usually must be treated by liver surgery, whereas the majority of distal cholangiocarcinomas require pancreaticoduodenectomy.
  • In case of a small, middle bile duct carcinoma, exclusive extrahepatic bile duct resection without pancreatic resection can be adequate.
  • Cancer of the distal bile duct has to be distinguished from ductal adenocarcinoma of the pancreas and carcinoma of the ampulla of Vater.
  • [MeSH-major] Bile Duct Neoplasms / surgery. Bile Ducts, Extrahepatic / surgery. Carcinoma, Pancreatic Ductal / surgery. Cholangiocarcinoma / surgery
  • [MeSH-minor] Ampulla of Vater / pathology. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / diagnosis. Common Bile Duct Neoplasms / mortality. Common Bile Duct Neoplasms / pathology. Common Bile Duct Neoplasms / surgery. Humans. Lymph Node Excision / methods. Neoplasm Invasiveness. Neoplasm Staging. Pancreaticoduodenectomy / methods. Prognosis. Survival Rate

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  • (PMID = 16523255.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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12. Takahashi S, Takada K, Kawano Y, Miyanishi K, Ishiwatari H, Hayashi T, Sagawa T, Sato T, Sato Y, Takimoto R, Kobune M, Kuroiwa G, Hirayama M, Tobioka H, Hirata K, Omatsu M, Hasegawa T, Kato J: [Cholangiocarcinoma with bile duct adenoma and hamartoma-like lesion in the bile duct]. Nihon Shokakibyo Gakkai Zasshi; 2010 Mar;107(3):461-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cholangiocarcinoma with bile duct adenoma and hamartoma-like lesion in the bile duct].
  • The tumor was subsequently resected, and histopathology showed a moderately differentiated adenocarcinoma.
  • This showed a number of bile ductules with variable amounts of stroma, well circumscribed but not encapsulated, so the lesion was diagnosed as a cholangiocarcinoma.
  • In addition, cystically dilated ductules resembling bile duct hamartoma and bile duct adenoma adjacent to the tumor were found, but with no area of transition among them.
  • In the Glisson's capsule around the tumor, there was also a bile duct hamartoma.
  • [MeSH-major] Adenoma / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic. Cholangiocarcinoma / pathology. Hamartoma / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 20203450.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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13. Sugo H, Yoshimoto J, Miwa K, Ishizaki Y, Kawasaki S: Anomalous intrahepatic portal system in a patient with hilar bile duct cancer. J Hepatobiliary Pancreat Surg; 2007;14(6):604-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anomalous intrahepatic portal system in a patient with hilar bile duct cancer.
  • We report a case of anomaly of the intrahepatic portal system in a 65-year-old man with hilar bile duct cancer.
  • [MeSH-major] Adenocarcinoma / surgery. Bile Duct Neoplasms / surgery. Portal System / abnormalities

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  • (PMID = 18040630.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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14. Takasawa O, Kobayashi G, Noda Y, Ito K, Horaguchi J, Fujita N, Kobari M: [A case of superficial bile duct carcinoma showing extensive intraductal spread without bile duct stenosis, diagnosed by intraductal ultrasonography]. Nihon Shokakibyo Gakkai Zasshi; 2007 Feb;104(2):226-32
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  • [Title] [A case of superficial bile duct carcinoma showing extensive intraductal spread without bile duct stenosis, diagnosed by intraductal ultrasonography].
  • We report a case of superficial bile duct carcinoma showing extensive intraductal spread without dilatation of the bile duct in which diagnosis was established preoperatively by transpapillary forceps biopsy and intraductal ultrasonography.
  • A 78-year-old man was given a diagnosis of acute cholecystitis, and percutaneous transhepatic gallbladder drainage (PTGBD) was performed.
  • Cholangiography via the PTGBD tube revealed a tiny irregularity in the hilar bile duct.
  • Transpapillary intraductal ultrasonography showed that this irregularity extended from the intrahepatic bile duct to the middle of the bile duct.
  • Bile duct biopsy revealed malignancy, and thus bile duct resection and hepaticojejunostomy were performed.
  • Histological examination verified a well-differentiated adenocarcinoma confined to the epithelium and the fibromuscular layer.
  • [MeSH-major] Adenocarcinoma / ultrasonography. Bile Duct Neoplasms / ultrasonography. Bile Ducts / ultrasonography
  • [MeSH-minor] Acute Disease. Aged. Biopsy. Cholecystitis / diagnosis. Drainage. Gallbladder / surgery. Hepatectomy. Humans. Jejunostomy. Male

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  • (PMID = 17283418.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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15. Zen Y, Sasaki M, Fujii T, Chen TC, Chen MF, Yeh TS, Jan YY, Huang SF, Nimura Y, Nakanuma Y: Different expression patterns of mucin core proteins and cytokeratins during intrahepatic cholangiocarcinogenesis from biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct--an immunohistochemical study of 110 cases of hepatolithiasis. J Hepatol; 2006 Feb;44(2):350-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Different expression patterns of mucin core proteins and cytokeratins during intrahepatic cholangiocarcinogenesis from biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct--an immunohistochemical study of 110 cases of hepatolithiasis.
  • BACKGROUND/AIMS: Two types of neoplastic lesions preceding invasive intrahepatic cholangiocarcinoma (ICC) are identified: a flat-type neoplastic lesion called 'biliary intraepithelial neoplasia (BilIN)' and an intraductal papillary neoplasm of the bile duct (IPN-B).
  • IPN-B was characterized by the intestinal phenotype (MUC2+/CK20+), and carcinogenesis leading to tubular adenocarcinoma was associated with increasing MUC1 expression and that to colloid carcinoma with MUC1-negativity.
  • Pathological stages of tubular adenocarcinoma of ICC with BilIN or IPN-B were more advanced than those of colloid carcinoma with IPN-B.
  • Increased expression of MUC1 in BilIN and also IPN-B is associated with tubular adenocarcinoma, while colloid carcinoma in IPN-B is characterized by MUC1-negativity and less advanced pathologic stages.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / pathology. Cholelithiasis / pathology. Keratins / biosynthesis. Mucins / biosynthesis
  • [MeSH-minor] Biomarkers, Tumor / biosynthesis. Diagnosis, Differential. Disease Progression. Humans. Immunohistochemistry. Neoplasm Staging. Precancerous Conditions

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  • [CommentIn] J Hepatol. 2006 Feb;44(2):249-50 [16360969.001]
  • (PMID = 16360234.001).
  • [ISSN] 0168-8278
  • [Journal-full-title] Journal of hepatology
  • [ISO-abbreviation] J. Hepatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins; 68238-35-7 / Keratins
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16. Kozaka K, Sasaki M, Fujii T, Harada K, Zen Y, Sato Y, Sawada S, Minato H, Matsui O, Nakanuma Y: A subgroup of intrahepatic cholangiocarcinoma with an infiltrating replacement growth pattern and a resemblance to reactive proliferating bile ductules: 'bile ductular carcinoma'. Histopathology; 2007 Sep;51(3):390-400
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A subgroup of intrahepatic cholangiocarcinoma with an infiltrating replacement growth pattern and a resemblance to reactive proliferating bile ductules: 'bile ductular carcinoma'.
  • AIMS: The histogenesis and biological behaviour of peripheral intrahepatic cholangiocarcinoma (peripheral CC) remain unclarified.
  • The aim of this study was to examine the growth pattern of peripheral CC (24 cases) in comparison with hepatocellular carcinoma (HCC, 27 cases) and metastatic colorectal adenocarcinoma (MCA, 24 cases).
  • Fifteen of 24 peripheral CCs were composed of carcinoma cells resembling reactive bile ductules and these cells were positive for neural cell adhesion molecule (NCAM), a marker of proliferating bile ductules.
  • The remaining nine peripheral CCs were composed of ordinary adenocarcinoma and negative for NCAM.
  • CONCLUSIONS: A subgroup of peripheral CCs with an infiltrating replacement growth pattern resembles reactive bile ductules and expresses NCAM.
  • 'Bile ductular carcinoma' may be a better term for this subgroup.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / pathology
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / secondary. Aged. Aged, 80 and over. Antigens, CD56 / analysis. Autopsy. Carcinoma, Hepatocellular / metabolism. Carcinoma, Hepatocellular / pathology. Colorectal Neoplasms / metabolism. Colorectal Neoplasms / secondary. Female. Humans. Immunohistochemistry. Keratins / analysis. Liver / chemistry. Liver / pathology. Liver Neoplasms / metabolism. Liver Neoplasms / pathology. Male. Middle Aged. Neural Cell Adhesion Molecules / analysis. Organ Size. Vimentin / analysis

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  • (PMID = 17553067.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / Neural Cell Adhesion Molecules; 0 / Vimentin; 68238-35-7 / Keratins
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17. Cha JM, Kim MH, Lee SK, Seo DW, Lee SS, Lee JH, Lee SG, Jang SJ: Clinicopathological review of 61 patients with early bile duct cancer. Clin Oncol (R Coll Radiol); 2006 Nov;18(9):669-77
MedlinePlus Health Information. consumer health - Bile Duct Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathological review of 61 patients with early bile duct cancer.
  • However, there is no broadly accepted concept of early bile duct cancer.
  • We aimed to assess whether early bile duct cancer patients have characteristic clinicopathological features and a better prognosis compared with patients with advanced bile duct cancer.
  • MATERIALS AND METHODS: Between June 1996 and December 2004, 614 patients were histologically confirmed with primary bile duct cancers after resection.
  • Extrahepatic early bile duct cancers are defined as carcinoma where invasion is confined within the fibromuscular layer of the extrahepatic bile duct.
  • Intrahepatic early bile duct cancers arising from intrahepatic large bile ducts are also defined as carcinoma confined within the fibromuscular layer.
  • RESULTS: Sixty-one (10%) patients were categorised with early bile duct cancers.
  • Not otherwise specified adenocarcinoma was only 67%, whereas papillary carcinoma was 31% of cancers.
  • The 5-year survival rate for early bile duct cancer was excellent (80%).
  • CONCLUSIONS: Although early bile duct cancer is not a common disease, it is not a very rare entity either.
  • The clinicopathological features of early bile duct cancer patients differ from those of advanced bile duct cancer patients, with asymptomatic clinical presentation, different macroscopic and microscopic findings, and excellent prognosis.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Cholangiocarcinoma / pathology

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  • (PMID = 17100152.001).
  • [ISSN] 0936-6555
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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18. Bickenbach K, Galka E, Roggin KK: Molecular mechanisms of cholangiocarcinogenesis: are biliary intraepithelial neoplasia and intraductal papillary neoplasms of the bile duct precursors to cholangiocarcinoma? Surg Oncol Clin N Am; 2009 Apr;18(2):215-24, vii
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular mechanisms of cholangiocarcinogenesis: are biliary intraepithelial neoplasia and intraductal papillary neoplasms of the bile duct precursors to cholangiocarcinoma?
  • Cholangiocarcinoma (CC) is a rare, malignant neoplasm that can develop from any site within the intrahepatic or extrahepatic biliary tree.
  • Although the key steps of cholangiocarcinogenesis remain unknown, it has been hypothesized that CC may develop through two key premalignant precursor lesions: biliary intraepithelial neoplasia (BilIN) and intraductal papillary neoplasm of the bile duct (IPNB).
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / pathology. Precancerous Conditions / pathology

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  • (PMID = 19306808.001).
  • [ISSN] 1055-3207
  • [Journal-full-title] Surgical oncology clinics of North America
  • [ISO-abbreviation] Surg. Oncol. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 50
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19. Lim JH, Jang KT, Choi D, Lee WJ, Lim HK: Early bile duct carcinoma: comparison of imaging features with pathologic findings. Radiology; 2006 Feb;238(2):542-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Early bile duct carcinoma: comparison of imaging features with pathologic findings.
  • PURPOSE: To retrospectively evaluate the imaging features of early bile duct carcinoma and to compare these features with histopathologic findings.
  • Twenty-one patients (13 men, eight women; mean age, 60 years; range, 48-75 years) with early bile duct carcinoma that was surgically resected and histopathologically confirmed were included.
  • Two radiologists retrospectively reviewed imaging features by consensus; they compared growth pattern of tumors, integrity of the bile duct wall that harbored the tumor, and periductal infiltration with histopathologic findings.
  • In four of the 10 intrahepatic cholangiocarcinomas, four of the five hilar cholangiocarcinomas, and six of the six extrahepatic cholangiocarcinomas, there were intraductal tumor masses and the wall of the tumor-bearing bile ducts was preserved without periductal infiltration on US and CT images.
  • CONCLUSION: Imaging features of early bile duct carcinoma are a tumor mass in the bile duct lumen and integrity of the tumor-bearing bile duct wall without infiltration outside the wall.
  • [MeSH-major] Adenocarcinoma / diagnosis. Bile Duct Neoplasms / diagnosis

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  • [Copyright] (c) RSNA, 2005
  • (PMID = 16396837.001).
  • [ISSN] 0033-8419
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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20. Tsuyuguchi T, Sakai Y, Sugiyama H, Miyakawa K, Ishihara T, Ohtsuka M, Miyazaki M, Yokosuka O: Endoscopic diagnosis of intraductal papillary mucinous neoplasm of the bile duct. J Hepatobiliary Pancreat Sci; 2010 May;17(3):230-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic diagnosis of intraductal papillary mucinous neoplasm of the bile duct.
  • BACKGROUND/PURPOSE: Intraductal papillary mucinous neoplasm of the bile duct (IPMN-B) is considered an uncommon tumor.
  • POCS was carried out after ERC and it showed the presence and locations of papillary tumors in all patients, except for one with a tumor in the peripheral intrahepatic bile duct (B3).
  • Six of the eight patients underwent surgical treatment; five patients underwent a hepatic resection with or without extrahepatic bile duct resection and one underwent a pancreaticoduodenectomy.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Papillary / pathology. Bile Duct Neoplasms / diagnosis. Bile Ducts, Extrahepatic. Bile Ducts, Intrahepatic. Endoscopy, Gastrointestinal

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  • (PMID = 19669677.001).
  • [ISSN] 1868-6982
  • [Journal-full-title] Journal of hepato-biliary-pancreatic sciences
  • [ISO-abbreviation] J Hepatobiliary Pancreat Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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21. Endo I, House MG, Klimstra DS, Gönen M, D'Angelica M, Dematteo RP, Fong Y, Blumgart LH, Jarnagin WR: Clinical significance of intraoperative bile duct margin assessment for hilar cholangiocarcinoma. Ann Surg Oncol; 2008 Aug;15(8):2104-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical significance of intraoperative bile duct margin assessment for hilar cholangiocarcinoma.
  • BACKGROUND: Frozen section analysis of bile duct margins is often used to guide the extent of surgical resection for hilar cholangiocarcinoma (HCCA), but the usefulness of this practice is unknown.
  • Final histopathology identified three subgroups on the basis of resection margin status: wide margin (bile duct and specimen margins negative for adenocarcinoma), narrow margin (bile duct margin negative but specimen margins positive), and positive margin (bile duct and specimen margins positive).
  • RESULTS: On the basis of frozen section analysis alone, 90 patients were thought to have a disease-negative bile duct margin intraoperatively.
  • Final histopathology showed that eight patients (9%) had invasive adenocarcinoma in the cuff of bile duct submitted for frozen section analysis.
  • Of the 82 patients with negative final bile duct margins, 54 patients were categorized as having wide margins, and 28 patients had narrow margins.
  • CONCLUSION: Frozen section analysis of the proximal bile duct margin is misleading in 9% of patients.
  • Among patients with HCCA who are determined to have negative duct margins intraoperatively, only 60% will have margins adequately wide enough to be associated with an improvement in DSS.
  • [MeSH-major] Adenocarcinoma / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / pathology. Neoplasm Recurrence, Local

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  • (PMID = 18543039.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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22. Park HJ, Jang KT, Heo JS, Choi YL, Han J, Kim SH: A potential case of intraductal tubulopapillary neoplasms of the bile duct. Pathol Int; 2010 Sep;60(9):630-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A potential case of intraductal tubulopapillary neoplasms of the bile duct.
  • We experienced an unusual intraductal growing bile duct tumor, which showed the same histopathologic and immunostaining profiles as ITPN of pancreas.
  • A 72-year-old female patient visited hospital due to intrahepatic stone.
  • The hilar bile duct tumor was detected and incidental lung mass was found in systemic evaluation.
  • The lung tumor was an adenocarcinoma, and the bile duct tumor showed poorly differentiated carcinoma with eosinophilic cytoplasm.
  • Lung lobectomy and hemihepatectomy were performed under the impression of double primary neoplasms of the lung adenocarcinoma and oncocytic variant of the biliary papillary tumor.
  • Both the lung and bile duct tumors showed a tubulopapillary pattern with high-grade nuclear atypia.
  • Eosinophilic cytoplasm of the bile duct tumor was not oncocytic cytoplasm but pyknotic change due to necrosis.
  • Here, we report the first case of ITPN of the bile duct with lung metastasis.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Bile Duct Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Adenocarcinoma / surgery. Aged. Carcinoma, Intraductal, Noninfiltrating / diagnosis. Carcinoma, Intraductal, Noninfiltrating / secondary. Carcinoma, Intraductal, Noninfiltrating / surgery. Female. Humans. Lung Neoplasms / diagnosis. Lung Neoplasms / secondary. Lung Neoplasms / surgery. Treatment Outcome

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  • (PMID = 20712650.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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23. Yoon YS, Kim SW, Jang JY, Park YH: Curative reoperation for recurrent cancer of the extrahepatic bile duct: report of two cases. Hepatogastroenterology; 2005 Mar-Apr;52(62):381-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Curative reoperation for recurrent cancer of the extrahepatic bile duct: report of two cases.
  • Local recurrence, following a resection for cancer of the extrahepatic bile duct, is usually incurable with second curative surgery being almost impossible.
  • The medical records and clinical outcomes of two patients that underwent a re-resection for recurrent cancer of the extrahepatic bile duct were retrospectively reviewed.
  • A 50-year-old female patient that had a recurrent disease at the intrahepatic and intrapancreatic bile duct, 66 months after a segmental resection of the bile duct for common bile duct (CBD) cancer, underwent a hepatopancreatoduodenectomy.
  • A 29-year-old female patient had a recurrent tumor mass in the distal CBD, 28 months after a right hemihepatectomy and Roux-en-Y hepaticojejenostomy for a type IIIa Klatskin tumor, and underwent a segmental resection of the bile duct.
  • It is concluded that a surgical re-resection is possible in selected patients with recurrent bile duct cancer, mostly of the papillary type.
  • A primary operation for bile duct cancer should be performed with a wide surgical margin, and secondary curative surgery should be considered whenever possible in cases of recurrence.
  • [MeSH-major] Adenocarcinoma, Papillary / surgery. Bile Duct Neoplasms / surgery. Bile Ducts, Extrahepatic. Klatskin Tumor / surgery

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  • (PMID = 15816441.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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24. Nakanishi Y, Zen Y, Hirano S, Tanaka E, Takahashi O, Yonemori A, Doumen H, Kawakami H, Itoh T, Nakanuma Y, Kondo S: Intraductal oncocytic papillary neoplasm of the bile duct: the first case of peribiliary gland origin. J Hepatobiliary Pancreat Surg; 2009;16(6):869-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraductal oncocytic papillary neoplasm of the bile duct: the first case of peribiliary gland origin.
  • We report herein the first case of intraductal oncocytic papillary neoplasm of the bile duct arising from a peribiliary gland of the left hepatic duct.
  • Radiological and cholangioscopic examinations revealed intraductal tumor of the left hepatic duct.
  • After pathological diagnosis of adenocarcinoma by cholangioscopic biopsy, a surgical hepatobiliary resection was performed.
  • Pathological examination revealed papillary tumor in the left hepatic duct.
  • Interestingly, this tumor originated from the cystic space in the bile duct wall.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Carcinoma in Situ / pathology

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  • (PMID = 19322511.001).
  • [ISSN] 1436-0691
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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25. Levy M, Lin F, Xu H, Dhall D, Spaulding BO, Wang HL: S100P, von Hippel-Lindau gene product, and IMP3 serve as a useful immunohistochemical panel in the diagnosis of adenocarcinoma on endoscopic bile duct biopsy. Hum Pathol; 2010 Sep;41(9):1210-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] S100P, von Hippel-Lindau gene product, and IMP3 serve as a useful immunohistochemical panel in the diagnosis of adenocarcinoma on endoscopic bile duct biopsy.
  • Histopathologic distinction between benign and malignant bile duct epithelial lesions on endoscopic biopsies can be extremely challenging because of limited material, crush artifact, and compounding inflammatory and/or reactive changes particularly after stent placement.
  • In this study, a total of 72 endoscopic bile duct biopsies, including 40 adenocarcinomas and 32 benign cases, were immunohistochemically examined for the expression of S100P, von Hippel-Lindau gene product (pVHL), and IMP3 to evaluate their diagnostic value.
  • In conclusion, an immunohistochemical panel consisting of S100P, pVHL, and IMP3 can be helpful in distinguishing adenocarcinoma from reactive epithelial changes on challenging bile duct biopsies.
  • [MeSH-major] Adenocarcinoma / diagnosis. Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic / pathology. Biomarkers, Tumor / analysis. Carrier Proteins / analysis. Nuclear Proteins / analysis. RNA-Binding Proteins / analysis. Von Hippel-Lindau Tumor Suppressor Protein / analysis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy. Carcinoma, Pancreatic Ductal / chemistry. Carcinoma, Pancreatic Ductal / diagnosis. Cholangiopancreatography, Endoscopic Retrograde. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Pancreatic Neoplasms / chemistry. Pancreatic Neoplasms / diagnosis. Precancerous Conditions / diagnosis

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • [CommentIn] Hum Pathol. 2011 Sep;42(9):1368; author reply 1368-9 [21704356.001]
  • (PMID = 20382408.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carrier Proteins; 0 / IMP3 protein, human; 0 / Nuclear Proteins; 0 / RNA-Binding Proteins; 0 / S100PBP protein, human; EC 6.3.2.19 / VHL protein, human; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
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26. Carter RR, Woodall CE 3rd, McNally ME, Talboy GE, Lankachandra KM, Van Way CW 3rd: Mixed ductal-endocrine carcinoma of the pancreas with synchronous papillary carcinoma-in-situ of the common bile duct: a case report and literature review--synchronous pancreatic and bile duct tumors. Am Surg; 2008 Apr;74(4):338-40
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  • [Title] Mixed ductal-endocrine carcinoma of the pancreas with synchronous papillary carcinoma-in-situ of the common bile duct: a case report and literature review--synchronous pancreatic and bile duct tumors.
  • This report is a case of a 58-year-old woman with a mixed ductal-endocrine carcinoma of the pancreas and a synchronous carcinoma-in-situ of the common bile duct.
  • Magnetic resonance imaging scan showed dilated intrahepatic biliary and common bile ducts.
  • Biopsies from this lesion showed adenocarcinoma.
  • Subsequently, pancreatoduodenectomy was performed for the diagnosis of peri-ampullary carcinoma.
  • Gross examination revealed a 2-cm irregular, ulcerated lesion obstructing the distal 0.5 cm of the common bile duct within the head of the pancreas.
  • On histopathological examination, it was discovered that this lesion contained two separate neoplasms: papillary carcinoma-in-situ of the intraparenchymal portion of the common bile duct and a mixed ductal-endocrine carcinoma of the pancreas.
  • Finding it in conjunction with a synchronous, overlying papillary carcinoma carcinoma-in-situ of the common bile duct has not been previously described.
  • [MeSH-major] Carcinoma in Situ / pathology. Carcinoma, Pancreatic Ductal / pathology. Common Bile Duct Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 18453301.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 8
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27. Tanaka M, Fukushima N, Noda N, Shibahara J, Kokudo N, Fukayama M: Intraductal oncocytic papillary neoplasm of the bile duct: clinicopathologic and immunohistochemical characteristics of 6 cases. Hum Pathol; 2009 Nov;40(11):1543-52
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  • [Title] Intraductal oncocytic papillary neoplasm of the bile duct: clinicopathologic and immunohistochemical characteristics of 6 cases.
  • Similar neoplasms of the bile duct are rarely reported, and their disease characteristics are not well established.
  • Grossly, 4 appeared to be cystic neoplasms with papillary projections located in the liver and the other two were papillary neoplasms of the dilated hilar bile duct that ranged from 1.5 to 16 cm in size.
  • [MeSH-major] Adenocarcinoma / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Carcinoma, Papillary / pathology

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  • (PMID = 19540556.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CLDN18 protein, human; 0 / Claudins; 0 / MUC5AC protein, human; 0 / MUC6 protein, human; 0 / Membrane Proteins; 0 / Mucin 5AC; 0 / Mucin-6
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28. Dechaphunkul A, Kanngurn S, Dechsukhum C, Tanutit P, Khow-Ean U, Sunpaweravong P: The significance of galectin-3 immunohistochemistry, clinical characteristics and liver imaging in differentiating intrahepatic cholangiocarcinoma from adenocarcinoma liver metastasis. J Med Assoc Thai; 2010 May;93(5):523-8
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  • [Title] The significance of galectin-3 immunohistochemistry, clinical characteristics and liver imaging in differentiating intrahepatic cholangiocarcinoma from adenocarcinoma liver metastasis.
  • OBJECTIVE: To identify differences of Galectin-3 (Gal-3) immunostaining, clinical profiles, and images in patients with intrahepatic cholangiocarcinoma (IHC) and adenocarcinoma liver metastasis, and be able to recognize these parameters as diagnostic tools for differentiating these two diseases.
  • MATERIAL AND METHOD: Histological slides from patients with IHC and adenocarcinoma liver metastasis were reviewed Immunohistochemical staining for Gal-3, Cytokeratin-7 (CK-7), and Cytokeratin-20 (CK-20) was performed and the results categorized.
  • RESULTS: Eighty-two patients were evaluated, 31 IHC and 51 adenocarcinoma liver metastasis.
  • Finding showed that 86% of them were IHC whereas only 14% were in adenocarcinoma liver metastasis.
  • All patients with liver images showing a single lesion, located at central site, and having intrahepatic duct dilatation were IHC.
  • On the other hand, 77% of patients with liver imaging showing multiple liver masses, located at peripheral site and having no intrahepatic duct dilatation were adenocarcinoma liver metastasis while only 23% were in IHC.
  • CONCLUSION: Adding Gal-3 to CK-7 and CK-20 immunohistochemistry has benefits to differentiate IHC from adenocarcinoma liver metastasis.
  • [MeSH-major] Adenocarcinoma / diagnosis. Bile Duct Neoplasms / diagnosis. Cholangiocarcinoma / diagnosis. Galectin 3 / metabolism. Liver Neoplasms / diagnosis
  • [MeSH-minor] Adult. Bile Ducts, Intrahepatic / metabolism. Bile Ducts, Intrahepatic / pathology. Biomarkers, Tumor / metabolism. Female. Humans. Immunohistochemistry. Keratin-20 / metabolism. Keratin-7 / metabolism. Liver / radiography. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 20524437.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Galectin 3; 0 / Keratin-20; 0 / Keratin-7
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29. Kaiho T, Tanaka T, Tsuchiya S, Yanagisawa S, Takeuchi O, Miura M, Saigusa N, Hayasaka A, Matsuzaki O, Miyazaki M: A case of small cell carcinoma of the common bile duct. Hepatogastroenterology; 2005 Mar-Apr;52(62):363-7
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  • [Title] A case of small cell carcinoma of the common bile duct.
  • We report a case of small cell carcinoma which occurred in the common bile duct.
  • Computed tomography and ultrasonography showed a mass near the pancreas head and dilatation of the intrahepatic bile ducts.
  • Endoscopic nasobiliary drainage was undertaken, and it revealed obstruction of the common bile duct.
  • The patient was diagnosed preoperatively as having extrahepatic bile duct cancer.
  • Upon laparotomy, a tumor was found to be located in the middle common bile duct.
  • Postoperative pathological examination revealed well-differentiated papillary adenocarcinoma on the surface of the bile duct lumen, but a large part of the extraductal component was small cell carcinoma.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Carcinoma, Small Cell / diagnosis. Common Bile Duct

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  • (PMID = 15816436.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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30. Itoi T, Sofuni A, Itokawa F, Tsuchiya T, Kurihara T: Evaluation of peroral videocholangioscopy using narrow-band imaging for diagnosis of intraductal papillary neoplasm of the bile duct. Dig Endosc; 2009 Jul;21 Suppl 1:S103-7
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  • [Title] Evaluation of peroral videocholangioscopy using narrow-band imaging for diagnosis of intraductal papillary neoplasm of the bile duct.
  • BACKGROUND: It is very important for intraductal papillary neoplasm of the bile duct (IPNB) to determine the extension of the neoplasms because of substantial differences in the approach to treatment strategy.
  • The aim of this study is to evaluate the clinical usefulness of PVCS using NBI for the diagnosis of IPNB.
  • We evaluated endoscopic imaging of white light imaging (WLI) and NBI for IPNB lesions, and ability of removing mucin in the bile duct by PVCS.
  • In the ability to detect the fine mucosal structure, NBI was predisposed to be better than conventional imaging while only one case was "poor" by NBI observation because we could not eliminate the influence of bile.
  • Although further cases should be accumulated, choledochoscopy using NBI may be helpful for the observation of fine mucosal structures, resulting in diagnosis of tumor spread in patients with IPNB.
  • [MeSH-major] Adenocarcinoma / diagnosis. Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic. Carcinoma, Papillary / diagnosis. Endoscopes, Gastrointestinal. Endoscopy, Gastrointestinal / methods. Video Recording / methods
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Equipment Design. Female. Humans. Male

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  • (PMID = 19691722.001).
  • [ISSN] 1443-1661
  • [Journal-full-title] Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
  • [ISO-abbreviation] Dig Endosc
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Australia
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31. Nanashima A, Kinoshita N, Nakanuma Y, Zen Y, Sumida Y, Abo T, Hidaka S, Takeshita H, Yasutake T, Hayashi T, Nagayasu T: Clinicopathological features of "intraductal papillary neoplasm of the bile duct" and patient outcome after surgical resection. Hepatogastroenterology; 2008 Jul-Aug;55(85):1167-73
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  • [Title] Clinicopathological features of "intraductal papillary neoplasm of the bile duct" and patient outcome after surgical resection.
  • BACKGROUND/AIMS: Intraductal papillary neoplasm of the bile duct (IPNB) represents a biliary papillary tumor mainly growing in the bile duct lumen resembling intraductal papillary mucin-producing neoplasm of the pancreas.
  • Imagery showed cystic or diffuse dilatation of the bile ducts.
  • Tumor markers were not valuable for diagnosis.
  • All patients underwent hemihepatectomy with or without resection of the caudate lobe or extrahepatic bile duct.
  • Five cases were well-differentiated adenocarcinoma and 1 had poorly differentiated adenocarcinoma.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic. Carcinoma / pathology. Carcinoma / surgery

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  • (PMID = 18795651.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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32. Zhao SM, Zhu XZ, Ji Y, Hou J: [Expression of mucin glycoproteins and cytokeratins in intrahepatic cholangiocarcinoma]. Zhonghua Bing Li Xue Za Zhi; 2008 Nov;37(11):749-53
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  • [Title] [Expression of mucin glycoproteins and cytokeratins in intrahepatic cholangiocarcinoma].
  • OBJECTIVE: To compare the immunoprofiles of intrahepatic cholangiocarcinoma and metastatic colorectal adenocarcinoma for mucin glycoproteins (including MUC1, MUC2, MUC5AC and MUC6) and cytokeratins (including CK7, CK19 and CK20), and to assess their diagnostic value.
  • METHODS: One hundred cases of intrahepatic cholangiocarcinoma and 21 cases of metastatic colorectal adenocarcinoma were enrolled into the study.
  • RESULTS: In intrahepatic cholangiocarcinoma, the expression rates of MUC1, MUC2, MUC5AC and MUC6 were 61.0%, 2.0%, 22.0% and 8.0% respectively, as compared to 57.1%, 47.6%, 19.0% and 23.8% respectively in metastatic colorectal adenocarcinoma.
  • On the other hand, the expression rates of CK7, CK19 and CK20 in intrahepatic cholangiocarcinoma were 73.0%, 53.0% and 15.0% respectively, in contrast to 14.3%, 90.5% and 85.7% respectively in metastatic colorectal adenocarcinoma.
  • CONCLUSIONS: The immunoprofile for mucin glycoproteins and cytokeratins provides important clues in distinguishing between intrahepatic cholangiocarcinoma and metastatic colorectal adenocarcinoma to liver.
  • The immunophenotype of MUC2-/MUC6-/CK7+/CK20- indicates the diagnosis of intrahepatic cholangiocarcinoma, while MUC2+/MUC6+/CK7-/CK20+ suggests the possibility of metastatic colorectal adenocarcinoma.
  • [MeSH-major] Bile Duct Neoplasms / metabolism. Bile Ducts, Intrahepatic / pathology. Biomarkers, Tumor / analysis. Cholangiocarcinoma / metabolism. Keratins / metabolism. Mucins / metabolism
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Aged. Colorectal Neoplasms / metabolism. Colorectal Neoplasms / pathology. Female. Glycoproteins / metabolism. Humans. Male. Middle Aged. Neoplasm Staging / classification

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  • (PMID = 19094709.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glycoproteins; 0 / Mucins; 68238-35-7 / Keratins
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33. Fujii T, Harada K, Katayanagi K, Kurumaya H, Nakanuma Y: Intrahepatic cholangiocarcinoma with multicystic, mucinous appearance and oncocytic change. Pathol Int; 2005 Apr;55(4):206-9
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  • [Title] Intrahepatic cholangiocarcinoma with multicystic, mucinous appearance and oncocytic change.
  • A case is reported herein of intrahepatic cholangiocarcinoma (ICC) with multicystic, mucinous appearance and oncocytic change.
  • She was diagnosed as having ICC of the right hepatic lobe with occlusion of the hilar and perihilar bile ducts by imaging examination.
  • Microscopically, these tumors were composed of multiple microcysts filled by abundant mucin and lined by micropapillary adenocarcinoma cells.
  • This is the third case of multicystic mucinous ICC and the present case might have been derived from intrahepatic peribiliary glands.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic. Cholangiocarcinoma / pathology
  • [MeSH-minor] Adenocarcinoma, Mucinous / pathology. Aged. Cysts / pathology. Female. Humans. Immunohistochemistry. Keratin-7. Keratins / analysis

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  • (PMID = 15826247.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / KRT7 protein, human; 0 / Keratin-7; 68238-35-7 / Keratins
  • [Number-of-references] 19
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34. Nakanishi Y, Ito T, Kubota K, Takeda H, Yonemori A, Kawakami H, Zen Y, Kondo S: Spindle cell-type undifferentiated carcinoma of the common bile duct of the hepatic hilus: report of a case. Surg Today; 2007;37(8):708-12
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  • [Title] Spindle cell-type undifferentiated carcinoma of the common bile duct of the hepatic hilus: report of a case.
  • Spindle cell-type undifferentiated carcinoma arising from the extrahepatic bile duct is extremely rare.
  • We herein report a case of this type of carcinoma in the common bile duct of the hepatic hilus.
  • Cholangiography revealed a complete obliteration of the left hepatic bile duct and stenosis of the bile duct from the superior to the right hepatic bile duct.
  • We preoperatively diagnosed hilus bile duct carcinoma and scheduled a right trisection hepatectomy.
  • As the right hepatic bile duct was occluded, a right lobe hepatectomy was performed.
  • However, a permanent section revealed both spindle cells and poorly differentiated tubular adenocarcinoma cells positive for CAM5.2, AE1/AE3, and vimentin.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / surgery. Carcinoma / pathology. Common Bile Duct / pathology. Hepatectomy / methods. Liver / surgery. Sarcoma / pathology

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  • (PMID = 17643221.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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35. Itatsu K, Zen Y, Ohira S, Ishikawa A, Sato Y, Harada K, Ikeda H, Sasaki M, Nimura Y, Nakanuma Y: Immunohistochemical analysis of the progression of flat and papillary preneoplastic lesions in intrahepatic cholangiocarcinogenesis in hepatolithiasis. Liver Int; 2007 Nov;27(9):1174-84
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  • [Title] Immunohistochemical analysis of the progression of flat and papillary preneoplastic lesions in intrahepatic cholangiocarcinogenesis in hepatolithiasis.
  • BACKGROUND: Two types of precursor lesions, flat-type 'biliary intraepithelial neoplasia (BilIN)' and papillary-type 'intraductal papillary neoplasm of the bile duct (IPNB)', are proposed in the tumorigenesis of intrahepatic cholangiocarcinoma (ICC) in hepatolithiasis.
  • [MeSH-major] Adenocarcinoma, Papillary / metabolism. Bile Duct Neoplasms / metabolism. Biomarkers, Tumor / metabolism. Cholangiocarcinoma / metabolism. Cholelithiasis / metabolism. Precancerous Conditions / metabolism
  • [MeSH-minor] Aged. Aged, 80 and over. Bile Ducts, Intrahepatic / metabolism. Bile Ducts, Intrahepatic / pathology. Cadherins / metabolism. Cyclin D. Cyclins / metabolism. Disease Progression. Disease-Free Survival. Female. Humans. Immunoenzyme Techniques. Male. Matrix Metalloproteinase 14 / metabolism. Matrix Metalloproteinase 7 / metabolism. Middle Aged. Proto-Oncogene Proteins c-myc / metabolism. beta Catenin / metabolism

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  • (PMID = 17919228.001).
  • [ISSN] 1478-3223
  • [Journal-full-title] Liver international : official journal of the International Association for the Study of the Liver
  • [ISO-abbreviation] Liver Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins; 0 / Cyclin D; 0 / Cyclins; 0 / MYC protein, human; 0 / Proto-Oncogene Proteins c-myc; 0 / beta Catenin; EC 3.4.24.23 / MMP7 protein, human; EC 3.4.24.23 / Matrix Metalloproteinase 7; EC 3.4.24.80 / MMP14 protein, human; EC 3.4.24.80 / Matrix Metalloproteinase 14
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36. Akatsu T, Shimazu M, Kawachi S, Tanabe M, Aiura K, Wakabashi G, Ueda M, Sakamoto M, Kitajima M: Long-term survival of intrahepatic cholangiocarcinoma with hilar lymph node metastasis and portal vein involvement. Hepatogastroenterology; 2005 Mar-Apr;52(62):603-5
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  • [Title] Long-term survival of intrahepatic cholangiocarcinoma with hilar lymph node metastasis and portal vein involvement.
  • We report the case of a very rare 6-year disease-free survivor of intrahepatic cholangiocarcinoma with hilar lymph node metastasis and portal vein involvement.
  • Cholangiography revealed complete obstruction of the left hepatic bile duct.
  • The patient underwent left hepatectomy with caudate lobectomy, resection of the extrahepatic bile duct, and lymphadenectomy.
  • Microscopically, the tumor was a poorly differentiated adenocarcinoma with many infiltrating lymphocytes, and extensive necrosis was present within the tumor.
  • The experience gained in the present case suggests that aggressive surgery may be a potential approach to provide a hope of long-term survival for patients with intrahepatic cholangiocarcinoma despite the presence of regional lymph node metastasis and vascular invasion.
  • [MeSH-major] Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic. Cholangiocarcinoma / surgery. Hepatectomy. Lymphatic Metastasis. Neoplasm Invasiveness / radiography. Portal Vein / radiography

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  • (PMID = 15816486.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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37. Yoshitomi M, Horiuchi H, Kawahara R, Uchida S, Hisaka T, Sakai T, Maruyama Y, Kinoshita H: [A case of intraluminal/external irradiation, chemotherapy and T-tube stent treatment for the local recurrence of the postoperative four-year bile duct cancer]. Gan To Kagaku Ryoho; 2008 Nov;35(12):2129-31
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  • [Title] [A case of intraluminal/external irradiation, chemotherapy and T-tube stent treatment for the local recurrence of the postoperative four-year bile duct cancer].
  • After confirmation of an expanded intrahepatic bile duct and anastomic stenosis in July 2005, PTBD was performed into the B3.
  • Adenocarcinoma was detected with bile cytodiagnosis, and was diagnosed as a recurrence of the left bile-duct anastomotic site.
  • We started administering of GEM (600 mg/body) every other week after the recurrence of the bile duct cancer.
  • We report a good result of the recurrent bile duct cancer treated with combined modality therapy.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Bile Duct Neoplasms / drug therapy. Bile Duct Neoplasms / radiotherapy. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / radiotherapy. Stents

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  • (PMID = 19106546.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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38. Ghittoni G, Caturelli E, Viera FT: Intrabile duct metastasis from colonic adenocarcinoma without liver parenchyma involvement: contrast enhanced ultrasonography detection. Abdom Imaging; 2010 Jun;35(3):346-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intrabile duct metastasis from colonic adenocarcinoma without liver parenchyma involvement: contrast enhanced ultrasonography detection.
  • It is well-known that biliary duct invasion with intraluminal growth is one of the developmental patterns of primary liver tumors, and macroscopic intrabiliary growth of liver metastases in colorectal cancer is found with high frequency.
  • However, many patients die of intrahepatic and/or extrahepatic recurrence after the resection.
  • We describe the first recorded case of a metastasis from colorectal cancer involving solely the common hepatic biliary duct, without invasion of contiguous liver parenchyma.
  • A correct diagnosis was obtained by means of contrast enhanced ultrasound and ultrasound-guided fine needle aspiration biopsy.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Colonic Neoplasms / pathology. Hepatic Duct, Common / pathology. Ultrasonography, Doppler, Color
  • [MeSH-minor] Aged. Biopsy, Fine-Needle. Cholangiography. Common Bile Duct / pathology. Common Bile Duct / ultrasonography. Humans. Image Enhancement. Lymphatic Metastasis. Male. Neoplasm Invasiveness

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  • (PMID = 19294464.001).
  • [ISSN] 1432-0509
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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39. Enomoto K, Amano S, Sakurai K: [Two cases of obstructive jaundice that developed with breast cancer hepatic metastasis--a treatment by a bile duct stent obtaining high efficacy]. Gan To Kagaku Ryoho; 2006 Nov;33(12):1907-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Two cases of obstructive jaundice that developed with breast cancer hepatic metastasis--a treatment by a bile duct stent obtaining high efficacy].
  • A Treatment by a Bile Duct Stent Obtaining High Efficacy: Katsuhisa Enomoto, Sadao Amano and Kenichi Sakurai (Division of Breast and Breast cancer hepatic metastasis with icterus is poor in prognosis and an active treatment is hardly performed.
  • However, we improved patients' QOL by inserting a bile duct stent as a topical treatment.
  • We also confirmed multiple hepatic metastases and intrahepatic bile duct dilation.
  • We detained a bile duct stent and performed a treatment to decrease the icterus.
  • We confirmed multiple hepatic metastases in October 2005 and inserted a bile duct stent because we detected an expansion of the intrahepatic bile duct.
  • In conclusion, it appears that a bile duct stent has improved patients' QOL in the cases where obstructive jaundice developed with breast cancer hepatic metastasis.
  • [MeSH-major] Adenocarcinoma / pathology. Breast Neoplasms / pathology. Carcinoma, Papillary / pathology. Jaundice, Obstructive / etiology. Jaundice, Obstructive / therapy. Liver Neoplasms / secondary. Stents
  • [MeSH-minor] Bile Ducts. Bilirubin / blood. Female. Humans. Lymph Node Excision. Mastectomy. Middle Aged. Quality of Life

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  • (PMID = 17212143.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] RFM9X3LJ49 / Bilirubin
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40. Miwa S, Miyagawa S, Kobayashi A, Akahane Y, Nakata T, Mihara M, Kusama K, Soeda J, Ogawa S: Predictive factors for intrahepatic cholangiocarcinoma recurrence in the liver following surgery. J Gastroenterol; 2006 Sep;41(9):893-900
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Predictive factors for intrahepatic cholangiocarcinoma recurrence in the liver following surgery.
  • BACKGROUND: We performed hepatectomy without lymph node (LN) dissection for intrahepatic cholangiocarcinoma (ICC) limited to the peripheral region of the liver, and hepatectomy with extrahepatic bile duct resection and regional LN dissection for any types of ICC extending to the hepatic hilum.
  • Surgical outcomes were evaluated to elucidate the prognostic factors that influence patient survival with respect to intrahepatic recurrence.
  • RESULTS: Significant risk factors for poorer survival included preoperative jaundice (P = 0.0115), serum CA19-9 levels >37 U/ml (P = 0.0089), tumor diameter >4.5 cm (P = 0.017), ICC extending to the hepatic hilum (P = 0.0065), mass-forming with periductal-infiltrating type (P = 0.003), poorly differentiated adenocarcinoma, portal vein involvement (P = 0.0785), LN metastasis at initial hepatectomy (P < 0.0001), and positive surgical margin (P = 0.023).
  • Intrahepatic recurrence, which was the predominant manner of recurrence, was detected in 20 patients (74.1%).
  • Patients with intrahepatic recurrence had a significantly high incidence of high serum CA19-9 levels (>37 U/ml; P = 0.0006), preoperative jaundice (P = 0.0262), ICC extended to the hepatic hilum (P = 0.0349), large tumors (>4.5 cm; P = 0.0351), portal vein involvement (P = 0.0423), and LN metastasis at initial hepatectomy (P = 0.009) compared with disease-free patients.
  • The multiple logistic regression analysis revealed that preoperative CA19-9 elevation and obstructive jaundice influenced intrahepatic recurrence of ICC.
  • CONCLUSIONS: Although LN metastasis is a significant prognostic factor, the most obvious recurrence pattern after surgery was intrahepatic recurrence, which could be predicted preoperatively by a combination of elevated serum CA19-9 levels and manifestation of obstructive jaundice.
  • [MeSH-major] Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic. Cholangiocarcinoma / surgery. Hepatectomy. Neoplasm Recurrence, Local / epidemiology

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  • [CommentIn] J Gastroenterol. 2006 Sep;41(9):925-6 [17048061.001]
  • (PMID = 17048054.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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41. Mannai S, Kraïem T, Gharbi L, Haoues N, Mestiri H, Khalfallah MT: [Congenital cystic dilatation of bile ducts]. Ann Chir; 2006 Jul-Aug;131(6-7):369-74
MedlinePlus Health Information. consumer health - Bile Duct Diseases.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Congenital cystic dilatation of bile ducts].
  • Congenital cystic dilatation of bile ducts is a rare condition.
  • We report a retrospective study about 18 patients having congenital bile duct cysts.
  • Anatomopathologic examination showed an adenocarcinoma of a common bile duct cyst.
  • In one case, a cancer of the gall bladder associated to a common bile duct cyst in another case.
  • Three patients with segmental dilatation of intrahepatic bile ducts (type V) underwent liver resection.
  • Congenital cystic dilatation of bile ducts is considered to be a precancer state.
  • [MeSH-major] Bile Duct Diseases / congenital. Bile Ducts / abnormalities. Choledochal Cyst. Cysts / congenital
  • [MeSH-minor] Acute Disease. Adolescent. Adult. Aged. Aged, 80 and over. Anastomosis, Surgical. Bile Ducts, Intrahepatic / abnormalities. Caroli Disease / diagnosis. Caroli Disease / surgery. Child. Child, Preschool. Cholangitis / etiology. Cholecystitis / complications. Dilatation. Dilatation, Pathologic / congenital. Drainage. Female. Hepatectomy. Humans. Jejunum / surgery. Liver / surgery. Male. Middle Aged. Postoperative Complications. Retrospective Studies

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  • (PMID = 16630531.001).
  • [ISSN] 0003-3944
  • [Journal-full-title] Annales de chirurgie
  • [ISO-abbreviation] Ann Chir
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
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42. Nakanuma Y, Sasaki M, Ikeda H, Sato Y, Zen Y, Kosaka K, Harada K: Pathology of peripheral intrahepatic cholangiocarcinoma with reference to tumorigenesis. Hepatol Res; 2008 Apr;38(4):325-34

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pathology of peripheral intrahepatic cholangiocarcinoma with reference to tumorigenesis.
  • Intrahepatic CCs can be divided into the perihilar and peripheral types.
  • Peripheral CCs present grossly as a mass forming tumor, and histologically as an adenocarcinoma of varying shapes and phenotypes.
  • Some peripheral CCs (ductular type) are characterized by: (i) a histological resemblance to reactive bile ductules;.
  • The other peripheral CC (duct type) includes ordinary adenocarcinoma with well to moderately differentiated tubular and micropapillary patterns and is negative for NCAM but positive for mucin.
  • This type can be called "duct CC," and shows a rather compressive growth.
  • The biological behavior of ductular CC and duct CC remains obscure, and follow-up and molecular studies on these tumors are required in order for these two CCs to be recognized as disease entities, and so as to evaluate their carcinogenesis.

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  • (PMID = 18093122.001).
  • [ISSN] 1386-6346
  • [Journal-full-title] Hepatology research : the official journal of the Japan Society of Hepatology
  • [ISO-abbreviation] Hepatol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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43. Kitagawa D, Taketomi A, Aishima S, Kuroda Y, Gion T, Shirabe K, Shimada M, Maehara Y: Recurrence of intrahepatic cholangiocarcinoma nine years after surgical resection. Hepatogastroenterology; 2008 May-Jun;55(84):1085-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrence of intrahepatic cholangiocarcinoma nine years after surgical resection.
  • This paper reports a rare case of intrahepatic cholangiocarcinoma (ICC) which recurred nine years after surgical resection.
  • The resected specimen showed well differentiated adenocarcinoma, which consisted of chiefly intraductal growth component.
  • [MeSH-major] Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic / surgery. Cholangiocarcinoma / surgery. Neoplasm Recurrence, Local / surgery
  • [MeSH-minor] Antigens, Neoplasm / blood. Biomarkers, Tumor / blood. Diagnosis, Differential. Female. Follow-Up Studies. Hepatectomy. Humans. Liver Function Tests. Lymph Node Excision. Middle Aged. Reoperation. Tomography, X-Ray Computed

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  • (PMID = 18705334.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / DU-PAN-2 antigen, human; 0 / pancreatic associated antigen, SPan-1
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44. Nishino R, Honda M, Yamashita T, Takatori H, Minato H, Zen Y, Sasaki M, Takamura H, Horimoto K, Ohta T, Nakanuma Y, Kaneko S: Identification of novel candidate tumour marker genes for intrahepatic cholangiocarcinoma. J Hepatol; 2008 Aug;49(2):207-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Identification of novel candidate tumour marker genes for intrahepatic cholangiocarcinoma.
  • BACKGROUND/AIMS: Specific markers are required for early detection and diagnosis of intrahepatic cholangiocarcinoma (ICC); however, the tumour markers currently in use are not specific for ICC.
  • Moreover, discrimination analysis revealed that a combination of these genes could be used to distinguish ICC from HCC or metastatic adenocarcinoma.
  • CONCLUSIONS: We identified novel marker genes of ICC that are potentially useful for the diagnosis of liver cancer.
  • [MeSH-major] Bile Duct Neoplasms / genetics. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Biomarkers, Tumor / genetics. Cholangiocarcinoma / genetics. Cholangiocarcinoma / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Male. Middle Aged. Oligonucleotide Array Sequence Analysis. Reverse Transcriptase Polymerase Chain Reaction

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  • [CommentIn] J Hepatol. 2008 Aug;49(2):160-2 [18538440.001]
  • (PMID = 18490072.001).
  • [ISSN] 0168-8278
  • [Journal-full-title] Journal of hepatology
  • [ISO-abbreviation] J. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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45. Nanashima A, Sumida Y, Abo T, Oikawa M, Murakami G, Takeshita H, Fukuoka H, Hidaka S, Nagayasu T, Sakamoto I, Sawai T: Relationship between pattern of tumor enhancement and clinicopathologic characteristics in intrahepatic cholangiocarcinoma. J Surg Oncol; 2008 Dec 1;98(7):535-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Relationship between pattern of tumor enhancement and clinicopathologic characteristics in intrahepatic cholangiocarcinoma.
  • AIM: Common enhancement pattern of intrahepatic cholangiocarcinoma (ICC) on computed tomography (CT) is that of hypovascular enhancement; however, in some cases, tumor shows identical enhancement in the arterial phase to that in hepatocellular carcinoma.
  • Well-differentiated adenocarcinoma was significantly more frequent in Type B than Type A.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / pathology. Image Enhancement

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18814285.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 4419T9MX03 / Iohexol
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46. Asakura H, Ohtsuka M, Ito H, Kimura F, Ambiru S, Shimizu H, Togawa A, Yoshidome H, Kato A, Miyazaki M: Long-term survival after extended surgical resection of intrahepatic cholangiocarcinoma with extensive lymph node metastasis. Hepatogastroenterology; 2005 May-Jun;52(63):722-4
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  • [Title] Long-term survival after extended surgical resection of intrahepatic cholangiocarcinoma with extensive lymph node metastasis.
  • We present a case of long-term survival in a patient that involved intrahepatic cholangiocarcinoma that metastasized to the paraaortic lymph nodes.
  • A 62-year-old man underwent extended left hepatic lobectomy with caudate lobe resection, extrahepatic bile duct resection, portal vein resection and reconstruction, and middle hepatic vein resection and reconstruction with lymph node dissection for a liver tumor that was located in the caudate lobe.
  • Histological examination of the resected specimen revealed moderately differentiated adenocarcinoma compatible with cholangiocarcinoma, and lymph node metastases were found in the area of the hepatoduodenal ligament and the paraaortic region.
  • [MeSH-major] Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic / surgery. Cholangiocarcinoma / surgery. Hepatectomy. Lymph Node Excision. Lymphatic Metastasis / pathology

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  • (PMID = 15966191.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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47. Okamura N, Yoshida M, Shibuya A, Sugiura H, Okayasu I, Ohbu M: Cellular and stromal characteristics in the scirrhous hepatocellular carcinoma: comparison with hepatocellular carcinomas and intrahepatic cholangiocarcinomas. Pathol Int; 2005 Nov;55(11):724-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cellular and stromal characteristics in the scirrhous hepatocellular carcinoma: comparison with hepatocellular carcinomas and intrahepatic cholangiocarcinomas.
  • Diagnosis was on the basis of a scirrhous histological pattern exceeding 50% of the tumor area.
  • Expression of cytoplasmic and extracellular matrix proteins was compared among SHCC, HCC and intrahepatic cholangiocarcinoma (ICC) cases with immunohistochemical staining.
  • [MeSH-major] Adenocarcinoma, Scirrhous / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Carcinoma, Hepatocellular / pathology. Cholangiocarcinoma / pathology. Liver Neoplasms / pathology

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  • (PMID = 16271085.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Collagen Type I; 0 / Collagen Type III; 0 / Laminin; 0 / Tenascin; 103107-01-3 / Fibroblast Growth Factor 2; 68238-35-7 / Keratins; EC 3.4.24.23 / Matrix Metalloproteinase 7
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48. Haas S, Gütgemann I, Wolff M, Fischer HP: Intrahepatic clear cell cholangiocarcinoma: immunohistochemical aspects in a very rare type of cholangiocarcinoma. Am J Surg Pathol; 2007 Jun;31(6):902-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intrahepatic clear cell cholangiocarcinoma: immunohistochemical aspects in a very rare type of cholangiocarcinoma.
  • Clear cell cholangiocarcinoma is a very unusual variant of peripheral bile duct carcinoma.
  • They also show CD56 expression which is a very uncommon finding for intrahepatic cholangiocarcinomas.
  • As CD56 expression is also found in reactive bile ducts and bile duct adenomas, one may speculate that these rare neoplasms may originate from reactive bile ducts or cholangiomatous lesions.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / pathology

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  • (PMID = 17527078.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / Keratin-7
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49. Nart D, Ertan Y, Pala EE, Zeytunlu M, Kilic M, Yilmaz F: Intrahepatic cholangiocarcinoma arising in chronic viral hepatitis-associated cirrhosis: two transplant cases. Transplant Proc; 2008 Dec;40(10):3813-5
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  • [Title] Intrahepatic cholangiocarcinoma arising in chronic viral hepatitis-associated cirrhosis: two transplant cases.
  • Recently, these viruses have been reported to have an etiologic role in the development of intrahepatic cholangiocarcinoma (ICC).
  • Herein we have reported two cases of HCV- and HBV-related cirrhosis with ICC in whom the pretransplant diagnosis was HCC.
  • On microscopic examination, all nodules exhibited typical morphological findings of adenocarcinoma.
  • In cirrhotic patients with active malignancy who are candidates for LDLT, ICC should be considered in the differential diagnosis.
  • [MeSH-major] Bile Duct Neoplasms / etiology. Bile Ducts, Intrahepatic. Cholangiocarcinoma / etiology. Hepatitis B / complications. Hepatitis B / surgery. Hepatitis C, Chronic / complications. Hepatitis C, Chronic / surgery. Liver Transplantation


50. Tamura T, Mizuyama Y, Shinto O, Nishihara T, Nakagawa H, Ono Y: [A long-term survival case of unresectable intrahepatic cholangiocarcinoma treated with chemotherapy]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2732-4
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  • [Title] [A long-term survival case of unresectable intrahepatic cholangiocarcinoma treated with chemotherapy].
  • CT scan revealed an intrahepatic cholangiocarcinoma in the left lobe.
  • Pathologically, it was moderately differentiated adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antimetabolites, Antineoplastic / therapeutic use. Bile Duct Neoplasms / drug therapy. Bile Ducts, Intrahepatic. Cholangiocarcinoma / drug therapy. Deoxycytidine / analogs & derivatives. Oxonic Acid / therapeutic use. Tegafur / therapeutic use

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  • (PMID = 21224695.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 0W860991D6 / Deoxycytidine; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; B76N6SBZ8R / gemcitabine
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51. Shimamura K, Kurosaki I, Sato D, Takano K, Yokoyama N, Sato Y, Hatakeyama K, Nakadaira K, Yagi M: Intrahepatic cholangiocarcinoma arising 34 years after excision of a type IV-A congenital choledochal cyst: report of a case. Surg Today; 2009;39(3):247-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intrahepatic cholangiocarcinoma arising 34 years after excision of a type IV-A congenital choledochal cyst: report of a case.
  • We report a rare case of intrahepatic cholangiocarcinoma (IHCC) arising many years after excision of a type IV-A congenital choledochal cyst.
  • Although he had no jaundice, the intrahepatic bile ducts showed cylinder-like dilatation with narrowing of the hilar bile duct.
  • At surgery, the tumor was found to arise from the dilated intrahepatic bile duct just above the narrow portion.
  • Microscopically, the tumor was confirmed to be moderate-to-well-differentiated tubular adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / etiology. Bile Duct Neoplasms / diagnosis. Bile Duct Neoplasms / etiology. Bile Ducts, Intrahepatic. Cholangiocarcinoma / etiology. Choledochal Cyst / complications. Choledochal Cyst / surgery

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  • (PMID = 19280286.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 31
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52. Yamashita Y, Taketomi A, Morita K, Fukuhara T, Ueda S, Sanefuji K, Iguchi T, Kayashima H, Sugimachi K, Maehara Y: The impact of surgical treatment and poor prognostic factors for patients with intrahepatic cholangiocarcinoma: retrospective analysis of 60 patients. Anticancer Res; 2008 Jul-Aug;28(4C):2353-9
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  • [Title] The impact of surgical treatment and poor prognostic factors for patients with intrahepatic cholangiocarcinoma: retrospective analysis of 60 patients.
  • BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) is a primary adenocarcinoma of the liver arising from the intrahepatic bile duct.
  • [MeSH-major] Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic / surgery. Cholangiocarcinoma / surgery. Liver Neoplasms / surgery

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  • (PMID = 18751418.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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53. Chiu CT, Chiang JM, Yeh TS, Tseng JH, Chen TC, Jan YY, Chen MF: Clinicopathological analysis of colorectal cancer liver metastasis and intrahepatic cholangiocarcinoma: are they just apples and oranges? Dig Liver Dis; 2008 Sep;40(9):749-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathological analysis of colorectal cancer liver metastasis and intrahepatic cholangiocarcinoma: are they just apples and oranges?
  • BACKGROUNDS/AIMS: Intrahepatic cholangiocarcinoma and colorectal cancer liver metastasis are the most primary and secondary adenocarcinoma of the liver, respectively.
  • METHODS: A total of 166 colorectal cancer liver metastasis patients and 206 intrahepatic cholangiocarcinoma patients who had undergone curative liver resection were retrospectively analysed.
  • Among 206 intrahepatic cholangiocarcinoma, there were 47 intraductal growth type-intrahepatic cholangiocarcinoma and 159 non-intraductal growth type-intrahepatic cholangiocarcinoma.
  • RESULTS: The intrahepatic cholangiocarcinoma patients were more female-predominated, associated with hepatolithiasis, symptomatic, jaundiced, and with larger tumour size compared with those of colorectal cancer liver metastasis.
  • Prognostic factors of intrahepatic cholangiocarcinoma were pathologic staging, histologic pattern and section margin; whereas prognostic factors of colorectal cancer liver metastasis were rectal origin, differentiation, section margin and bilobar distribution.
  • CK7 and CK20 differentiated majority of intrahepatic cholangiocarcinoma from colorectal cancer liver metastasis, while CDX2 and MUC5AC helped to differentiate inconclusive cases.
  • The 1-, 3-, 5- and 10-year survival rates of colorectal cancer liver metastasis were 77%, 31%, 20% and 14%, compared to 53%, 21%, 13% and 7% of intrahepatic cholangiocarcinoma (p=.0001).
  • Furthermore, the survival of colorectal cancer liver metastasis was comparable to staged II intrahepatic cholangiocarcinoma (p=.8866) and intraductal growth type-intrahepatic cholangiocarcinoma (p=.1915).
  • CONCLUSIONS: Demographics, precipitating factor, clinical manifestations, and prognostic factors of colorectal cancer liver metastasis and intrahepatic cholangiocarcinoma differed remarkably.
  • High incidence of CDX2 and MUC2 expression in colorectal cancer liver metastasis and intraductal growth type-intrahepatic cholangiocarcinoma might explain their similar cytoarchitecture and survival.
  • [MeSH-major] Adenocarcinoma / secondary. Bile Duct Neoplasms / pathology. Biomarkers, Tumor / analysis. Cholangiocarcinoma / pathology. Colorectal Neoplasms / pathology. Liver Neoplasms / secondary
  • [MeSH-minor] Aged. Bile Ducts, Intrahepatic. Biopsy, Needle. Cohort Studies. Female. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Probability. Prognosis. Retrospective Studies. Risk Assessment. Statistics, Nonparametric. Survival Analysis


54. Shirabe K, Mano Y, Taketomi A, Soejima Y, Uchiyama H, Aishima S, Kayashima H, Ninomiya M, Maehara Y: Clinicopathological prognostic factors after hepatectomy for patients with mass-forming type intrahepatic cholangiocarcinoma: relevance of the lymphatic invasion index. Ann Surg Oncol; 2010 Jul;17(7):1816-22
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  • [Title] Clinicopathological prognostic factors after hepatectomy for patients with mass-forming type intrahepatic cholangiocarcinoma: relevance of the lymphatic invasion index.
  • BACKGROUND: The present study was conducted to clarify the pathological factors in patients who underwent surgery for mass-forming type intrahepatic cholangiocarcinoma (IHC).
  • The portal venous (PV) invasion index was defined as follows: PV0, portal venous invasion (-) and intrahepatic metastasis (-); PV1, portal venous invasion (+) or intrahepatic metastasis (+); PV2, portal venous invasion (+) and intrahepatic metastasis (+).
  • The lymphatic invasion (LI) index was defined as follows: LI0, lymphatic duct invasion (-) and lymph node metastasis (-); LI1, intrahepatic lymphatic duct invasion (+) or lymph node metastasis (+); LI2, intrahepatic lymphatic duct invasion (+) and lymph node metastasis (+).
  • Stratification of the lymphatic invasion pathway by lymphatic invasion, including intrahepatic lymphatic duct invasion and lymph node metastasis, is a good predictor for prognosis in patients after hepatectomy for mass-forming type IHC.
  • [MeSH-major] Adenocarcinoma / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / pathology. Hepatectomy. Liver Neoplasms / secondary

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  • (PMID = 20135355.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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55. Gambarotti M, Medicina D, Baronchelli C, Bercich L, Bonetti F, Facchetti F: Alpha-1-antitrypsin-positive "signet-ring" bile duct adenoma in a patient with M(MALTON) mutation. Int J Surg Pathol; 2008 Apr;16(2):218-21
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  • [Title] Alpha-1-antitrypsin-positive "signet-ring" bile duct adenoma in a patient with M(MALTON) mutation.
  • A 65-year-old man with a colonic adenocarcinoma and a single small liver nodule underwent surgery.
  • The nodule showed the histological features of a bile duct adenoma.
  • The selective recurrence of large alpha-1-antitrypsin globules within the bile ducts may indicate a neoplastic rather than a reactive or hamartomatous nature of the nodule.
  • [MeSH-major] Adenoma / genetics. Bile Duct Neoplasms / genetics. Bile Ducts, Intrahepatic. Mutation. alpha 1-Antitrypsin / genetics

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  • (PMID = 18417685.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha 1-Antitrypsin
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56. Kirimlioğlu H, Türkmen I, Başsüllü N, Dirican A, Karadağ N, Kirimlioğlu V: The expression of matrix metalloproteinases in intrahepatic cholangiocarcinoma, hilar (Klatskin tumor), middle and distal extrahepatic cholangiocarcinoma, gallbladder cancer, and ampullary carcinoma: role of matrix metalloproteinases in tumor progression and prognosis. Turk J Gastroenterol; 2009 Mar;20(1):41-7
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  • [Title] The expression of matrix metalloproteinases in intrahepatic cholangiocarcinoma, hilar (Klatskin tumor), middle and distal extrahepatic cholangiocarcinoma, gallbladder cancer, and ampullary carcinoma: role of matrix metalloproteinases in tumor progression and prognosis.
  • Biliary neoplasms are classified into intra- and extrahepatic cholangiocarcinoma (Klatskin tumor, middle and distal extrahepatic tumors), gallbladder adenocarcinoma, and ampullary carcinoma.
  • METHODS: Ten gallbladder adenocarcinoma, 8 distal bile duct carcinomas (distal cholangiocarcinoma), 8 Klatskin tumors, 8 intrahepatic cholangiocarcinomas and 10 ampullary carcinomas were included in the study.
  • RESULTS: The nontumoral epithelia of the gallbladder, intrahepatic ducts, and Klatskin tumor did not express MMP-2.
  • The metaplastic and dysplastic epithelia were positively stained in all of the gallbladder adenocarcinoma, distal cholangiocarcinoma and ampullary tumors.
  • In the intrahepatic cholangiocarcinoma, the hepatocytes were positively stained but the infiltrative tumors were spared.
  • The gallbladder adenocarcinoma, distal cholangiocarcinoma and ampullary carcinomas expressed MMP-2 in 30%, 37% and 40% of the cases, respectively.
  • CONCLUSIONS: When tumors of the biliary system are divided as intrahepatic and extrahepatic cholangiocarcinomas, MMP-2 expression was present in the extrahepatic cholangiocarcinomas including gallbladder carcinomas.
  • Like the intrahepatic cholangiocarcinoma, Klatskin tumors also did not express MMP-2.
  • MMP-9 and MMP- 14 were present in metaplasia, dysplasia carcinoma sequence in all of the bile tract tumors, suggesting that MMPs play an important role in carcinogenesis.
  • [MeSH-major] Bile Duct Neoplasms / metabolism. Bile Ducts, Intrahepatic / enzymology. Cholangiocarcinoma / metabolism. Matrix Metalloproteinases / metabolism
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Ampulla of Vater / enzymology. Ampulla of Vater / pathology. Disease Progression. Gallbladder Neoplasms / metabolism. Gallbladder Neoplasms / pathology. Hepatic Duct, Common / enzymology. Hepatic Duct, Common / pathology. Humans. Immunohistochemistry. Klatskin Tumor / metabolism. Klatskin Tumor / pathology. Matrix Metalloproteinase 14 / metabolism. Matrix Metalloproteinase 2 / metabolism. Matrix Metalloproteinase 9 / metabolism. Neoplasm Invasiveness. Prognosis

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  • (PMID = 19330734.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] EC 3.4.24.- / Matrix Metalloproteinases; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9; EC 3.4.24.80 / Matrix Metalloproteinase 14
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57. Seshadri RA, Majhi U: Endobiliary metastasis from rectal cancer mimicking intrahepatic cholangiocarcinoma: a case report and review of literature. J Gastrointest Cancer; 2009;40(3-4):123-7
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  • [Title] Endobiliary metastasis from rectal cancer mimicking intrahepatic cholangiocarcinoma: a case report and review of literature.
  • PURPOSE: The purpose of this study is to report an unusual case of liver metastasis from carcinoma rectum, which mimicked an intrahepatic cholangiocarcinoma (ICC) radiologically and pathologically, and to review the relevant literature.
  • Two years later, he was found to have a nodule in the left hepatic duct on imaging.
  • FINDINGS: The specimen revealed a tumor in the left hepatic duct, microscopically resembling an ICC.
  • [MeSH-major] Adenocarcinoma / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / pathology. Liver Neoplasms / secondary. Rectal Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Diagnosis, Differential. Digestive System Surgical Procedures. Humans. Immunohistochemistry. Keratin-20 / metabolism. Keratin-7 / metabolism. Magnetic Resonance Imaging. Male. Middle Aged. Neoadjuvant Therapy. Neoplasm Staging. Radiotherapy

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  • (PMID = 19921471.001).
  • [ISSN] 1941-6636
  • [Journal-full-title] Journal of gastrointestinal cancer
  • [ISO-abbreviation] J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratin-20; 0 / Keratin-7
  • [Number-of-references] 17
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58. Yeh TS, Tseng JH, Chiu CT, Liu NJ, Chen TC, Jan YY, Chen MF: Cholangiographic spectrum of intraductal papillary mucinous neoplasm of the bile ducts. Ann Surg; 2006 Aug;244(2):248-53
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  • [Title] Cholangiographic spectrum of intraductal papillary mucinous neoplasm of the bile ducts.
  • OBJECTIVE: To propose a cholangiographic classification for intraductal growth type intrahepatic cholangiocarcinoma (IG-ICC) and its precursor, collectively termed intraductal papillary mucinous neoplasm of the bile ducts (IPMN-B).
  • [MeSH-major] Adenocarcinoma, Mucinous / classification. Bile Duct Neoplasms / classification. Bile Ducts, Intrahepatic / radiography. Cholangiography / methods. Precancerous Conditions / classification
  • [MeSH-minor] Bile. Cholangiocarcinoma / classification. Cholangiocarcinoma / pathology. Cholangiocarcinoma / radiography. Cholangiocarcinoma / surgery. Female. Gallstones / radiography. Hepatectomy. Humans. Lithiasis / radiography. Male. Middle Aged. Retrospective Studies. Survival Rate

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  • (PMID = 16858187.001).
  • [ISSN] 0003-4932
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1602176
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59. Sato K, Murai H, Ueda Y, Katsuda S: Intrahepatic sarcomatoid cholangiocarcinoma of round cell variant: a case report and immunohistochemical studies. Virchows Arch; 2006 Nov;449(5):585-90
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  • [Title] Intrahepatic sarcomatoid cholangiocarcinoma of round cell variant: a case report and immunohistochemical studies.
  • Sarcomatoid transformation was observed in 4.5% of autopsied cases of intrahepatic cholangiocarcinoma.
  • Here, we report a case of intrahepatic sarcomatoid cholangiocarcinoma with round cell feature, extremely rare variant.
  • The patient was clinically diagnosed to have intrahepatic cholangiocarcinoma and received palliative care without specific treatment.
  • He died of hepatic insufficiency 3 months after the diagnosis.
  • Histologically, the tumor was centrally hemorrhagic and necrotic and was composed of tubular adenocarcinoma and a round cell component, which has an eccentrically located nucleus and eosinophilic cytoplasm without mucin production.
  • Immunohistochemically, the adenocarcinoma cells expressed cytokeratin 19 and beta-catenin in their cytoplasm, with E-cadherin and CD44s at the plasma membrane.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic. Cholangiocarcinoma / pathology

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  • (PMID = 17033799.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD44; 0 / Cadherins; 0 / beta Catenin
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60. Tomizawa M, Tsuyuguchi T, Sakai Y, Sugiyama H, Miyakawa K, Ishihara T, Yokosuka O: [Case of intrahepatic cholangiocarcinoma drained through a fistula of the duodenal bulb]. Nihon Shokakibyo Gakkai Zasshi; 2010 Dec;107(12):1970-7
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  • [Title] [Case of intrahepatic cholangiocarcinoma drained through a fistula of the duodenal bulb].
  • Since she complained epigastralgia, upper gastrointestinal endoscopy was performed, showing an ulcer in the duodenal bulb, with poorly-differentiated adenocarcinoma seen on a biopsy specimen from the edge of the ulcer.
  • After admission, poorly-differentiated adenocarcinoma cells were also obtained with ultrasound guided aspiration cytology of the liver tumor.
  • We diagnosed intrahepatic cholangiocarcinoma (IHC), and treated with gemcitabine.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic. Duodenal Diseases / pathology. Duodenal Neoplasms / pathology. Intestinal Fistula / pathology

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  • (PMID = 21139367.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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61. Khunamornpong S, Siriaunkgul S, Suprasert P, Pojchamarnwiputh S, Na Chiangmai W, Young RH: Intrahepatic cholangiocarcinoma metastatic to the ovary: a report of 16 cases of an underemphasized form of secondary tumor in the ovary that may mimic primary neoplasia. Am J Surg Pathol; 2007 Dec;31(12):1788-99
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  • [Title] Intrahepatic cholangiocarcinoma metastatic to the ovary: a report of 16 cases of an underemphasized form of secondary tumor in the ovary that may mimic primary neoplasia.
  • The potential for adenocarcinoma metastatic to the ovary to mimic primary mucinous neoplasms is a well-known issue to surgical pathologists, most of the recent literature emphasizing pancreatic and various other origins for the ovarian metastases.
  • Although an origin in the gallbladder or extrahepatic bile ducts is acknowledged for some cases little information exists on tumors originating within the intrahepatic bile ducts.
  • Intrahepatic cholangiocarcinoma should be included in the list of origins of possible ovarian metastatic tumors that mimic primary ovarian mucinous neoplasia, particularly in parts of the world where cholangiocarcinoma of the liver is relatively common.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Cholangiocarcinoma / secondary. Ovarian Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Bile Ducts, Intrahepatic / pathology. Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 18043033.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Miyazawa M, Torii T, Toshimitsu Y, Kamizasa N, Suzuki T, Shinozuka N, Ishizawa K, Koyama I: Alpha-fetoprotein-producing clear cell carcinoma of the extrahepatic bile ducts. J Clin Gastroenterol; 2006 Jul;40(6):555-7
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  • [Title] Alpha-fetoprotein-producing clear cell carcinoma of the extrahepatic bile ducts.
  • Her abdominal computed tomography scan revealed dilation of the intrahepatic bile duct and a tumorlike lesion protruding into the cystic duct and gallbladder from the junction between the middle portion of the bile duct and the right and left hepatic ducts.
  • Surgery revealed a tumor extending from the extrahepatic bile duct (EHBD) to the cystic duct, with no intrahepatic tumor components.
  • [MeSH-major] Adenocarcinoma, Clear Cell / metabolism. Bile Duct Neoplasms / metabolism. Bile Ducts, Extrahepatic / metabolism. Cholangiocarcinoma / metabolism. alpha-Fetoproteins / metabolism

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  • (PMID = 16825940.001).
  • [ISSN] 0192-0790
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha-Fetoproteins
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63. Barakat O, Cooper JR Jr, Riggs SA, Hoef JW, Ozaki CF, Wood RP: Complex liver resection for a large intrahepatic cholangiocarcinoma in a Jehovah's witness: a strategy to avoid transfusion. J Surg Oncol; 2007 Sep 1;96(3):249-53
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  • [Title] Complex liver resection for a large intrahepatic cholangiocarcinoma in a Jehovah's witness: a strategy to avoid transfusion.
  • In this report, we describe the use of a combined left trisegmentectomy and caudate lobectomy, along with resection of the inferior vena cava, to treat a large intrahepatic cholangiocarcinoma in a Jehovah's Witness.
  • [MeSH-major] Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic / surgery. Cholangiocarcinoma / surgery. Digestive System Surgical Procedures / methods. Jehovah's Witnesses. Liver / surgery
  • [MeSH-minor] Adenocarcinoma / surgery. Blood Loss, Surgical / prevention & control. Female. Hemodilution. Humans. Liver Neoplasms / surgery. Middle Aged. Vena Cava, Inferior / surgery

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17443725.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Paik KY, Heo JS, Choi SH, Choi DW: Intraductal papillary neoplasm of the bile ducts: the clinical features and surgical outcome of 25 cases. J Surg Oncol; 2008 May 1;97(6):508-12
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  • [Title] Intraductal papillary neoplasm of the bile ducts: the clinical features and surgical outcome of 25 cases.
  • BACKGROUND AND OBJECTIVES: Intraductal papillary neoplasm of the bile ducts (IPN-B) is considered an uncommon tumor.
  • Radiologically, 23 of the 25 (92.0%) showed bile duct dilatation, bile duct dilatation with or without an intraductal mass, and cystic changes of bile ducts.
  • Twenty three of the 25 patients underwent hepatic resection with or without extrahepatic bile duct resection.
  • CONCLUSIONS: A diagnosis of IPN-B is usually made in patients with biliary dilatation by radiologic study.
  • [MeSH-major] Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic / surgery. Carcinoma, Papillary / surgery
  • [MeSH-minor] Adenocarcinoma, Mucinous / secondary. Adenocarcinoma, Mucinous / surgery. Adult. Aged. Cholangiocarcinoma / secondary. Cholangiocarcinoma / surgery. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local / diagnosis. Prognosis. Survival Rate. Treatment Outcome

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 18314868.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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65. Chu PG, Schwarz RE, Lau SK, Yen Y, Weiss LM: Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2. Am J Surg Pathol; 2005 Mar;29(3):359-67
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  • [Title] Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2.
  • We studied the expression of cytokeratin 7 (CK7), cytokeratin 17 (CK17), cytokeratin 20 (CK20), CDX2, mucin 1 (MUC1), mucin 2 (MUC2), and mucin 5AC (MUC5AC) in 46 cases of pancreatic ductal carcinoma, 18 ampulla of Vater adenocarcinomas, and 24 intrahepatic cholangiocarcinomas.
  • The expression of MUC1 and CK17 was restricted to pancreatic ductal carcinoma (41 of 46, 89%; 38 of 46, 83%, respectively), the ampullary carcinoma of pancreatobiliary origin (6 of 6, 100%; 5 of 6, 83%, respectively), and intrahepatic cholangiocarcinoma (20 of 24, 83%; 17 of 24, 71%, respectively).
  • MUC2 was rarely expressed in pancreatic ductal carcinoma (1 of 46, 2%) and was negative in the ampullary carcinoma of pancreatobiliary origin and in intrahepatic cholangiocarcinoma.
  • A heterogeneous CDX2 staining pattern was seen in 1 of 6 cases of the ampullary carcinoma of pancreatobiliary origin (17%), 5 of 24 intrahepatic cholangiocarcinomas (21%), and 10 of 46 (22%) pancreatic ductal carcinomas.
  • MUC2+/CDX2+ can be used as positive markers for the intestinal-type adenocarcinoma of duodenal papillary origin with a positive predictive value of 82%.
  • [MeSH-major] Ampulla of Vater / pathology. Bile Ducts, Intrahepatic / pathology. Carcinoma, Pancreatic Ductal / pathology. Cholangiocarcinoma / pathology. Common Bile Duct Neoplasms / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Biomarkers, Tumor / metabolism. Female. Homeodomain Proteins / metabolism. Humans. Immunohistochemistry. Keratins / metabolism. Male. Mucins / metabolism. Neoplasm Proteins / metabolism

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  • (PMID = 15725805.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / Mucins; 0 / Neoplasm Proteins; 68238-35-7 / Keratins
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66. Fraguela Mariña JA, Fernández Blanco C, Alonso Fernández L, Taboada Filgueira L, Robles Veiga O, Gómez Freijoso C: [Liver metastases from colonic adenocarcinoma simulating cholangiocarcinoma]. Gastroenterol Hepatol; 2007 Oct;30(8):454-6
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  • [Title] [Liver metastases from colonic adenocarcinoma simulating cholangiocarcinoma].
  • Macroscopic intrabiliary growth of liver metastases from colonic adenocarcinoma mimicking cholangiocarcinoma, a pattern of intrahepatic spread easily confused with primary neoplasia of the biliary tract, is extremely infrequent.
  • We report a case of metastasis from adenocarcinoma of the colon that presented as a Klatskin tumor.
  • The definitive diagnosis was established by immunostaining.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Bile Duct Neoplasms / diagnosis. Cholangiocarcinoma / diagnosis. Colonic Neoplasms / pathology. Klatskin Tumor / diagnosis. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 17949611.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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67. Chaudhary HB, Bhanot P, Logroño R: Phenotypic diversity of intrahepatic and extrahepatic cholangiocarcinoma on aspiration cytology and core needle biopsy: case series and review of the literature. Cancer; 2005 Aug 25;105(4):220-8
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  • [Title] Phenotypic diversity of intrahepatic and extrahepatic cholangiocarcinoma on aspiration cytology and core needle biopsy: case series and review of the literature.
  • BACKGROUND: Cholangiocarcinoma (CC) represents approximately 10% of primary liver malignancies and can mimic metastatic adenocarcinoma.
  • METHODS: The authors retrospectively reviewed the cytopathology files at the University of Texas Medical Branch to identify patients who were diagnosed with intrahepatic or extrahepatic CC by aspiration cytology between 1995 and 2004.
  • The phenotypic distribution of CC according to the World Health Organization (WHO) histologic classification was 9 adenocarcinoma (intrahepatic), not otherwise specified (NOS) (69%); 2 gastric foveolar type (extrahepatic) CCs (15%); 1 intestinal type (extrahepatic) CC (8%); and 1 sarcomatous/spindle cell type (intrahepatic) CC (8%).
  • One adenocarcinoma, NOS was well differentiated CC with bland tubular architecture, and one was pleomorphic.
  • CONCLUSIONS: Classification of intrahepatic and extrahepatic CC in aspiration cytology specimens was achieved in a reliable manner concordant with the WHO histologic classification.
  • The addition of core biopsy and/or ancillary studies, such as histochemical and immunochemical stains, were helpful in reaching the correct diagnosis.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts, Extrahepatic / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Phenotype. Retrospective Studies

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  • [Copyright] Copyright (c) 2005 American Cancer Society.
  • (PMID = 15952192.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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68. Taweevisit M, Chirakalwasan N, Pumsuk U, Keelawat S, Shuangshoti S: Metastatic adenocarcinoma to the cervical lymph node: a significant proportion of cholangiocarcinoma in Thai patients. Asian Pac J Cancer Prev; 2008 Jan-Mar;9(1):39-41
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  • [Title] Metastatic adenocarcinoma to the cervical lymph node: a significant proportion of cholangiocarcinoma in Thai patients.
  • OBJECTIVE: To determine distribution of the primary site of metastatic adenocarcinoma to the cervical lymph node in Thai population with histological correlation.
  • MATERIALS AND METHODS: 72 Thai patients with metastatic adenocarcinoma to the cervical lymph node were retrospectively analyzed.
  • RESULTS: Thyroid gland (papillary carcinoma) was the commonest source of tumor (41%), followed by lung (25%), bile duct (17%) and breast (7%).
  • This figure may hold true for countries where bile duct malignancy is endemic, and may be of clinical usefulness in identification of primary cancer.
  • [MeSH-major] Adenocarcinoma / secondary. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / secondary. Lymph Nodes / pathology

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  • (PMID = 18439070.001).
  • [ISSN] 2476-762X
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Thailand
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69. Lim JH, Jang KT, Choi D: Biliary intraductal papillary-mucinous neoplasm manifesting only as dilatation of the hepatic lobar or segmental bile ducts: imaging features in six patients. AJR Am J Roentgenol; 2008 Sep;191(3):778-82
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  • [Title] Biliary intraductal papillary-mucinous neoplasm manifesting only as dilatation of the hepatic lobar or segmental bile ducts: imaging features in six patients.
  • OBJECTIVE: The purpose of this study was to evaluate the imaging features of intrahepatic biliary intraductal papillary-mucinous neoplasm manifesting only as dilatation of the lobar or segmental bile ducts without a visible mass to determine whether this type of cholangiocarcinoma can be recognized on the basis of distinct imaging features.
  • CONCLUSION: Intrahepatic biliary intraductal papillary-mucinous neoplasm can spread along the mucosa without forming a mass and can produce a large amount of mucin.
  • Severe dilatation of the lobar or segmental intrahepatic bile ducts with crowding and severe atrophy of the hepatic parenchyma are helpful imaging findings.
  • [MeSH-major] Adenocarcinoma, Mucinous / radiography. Adenoma / radiography. Bile Duct Neoplasms / radiography. Liver Diseases / radiography. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Aged. Diagnosis, Differential. Dilatation, Pathologic. Female. Humans. Male. Middle Aged

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  • (PMID = 18716109.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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70. Sanada Y, Yoshida K, Konishi K, Oeda M, Ohara M, Tsutani Y: Expression of gastric mucin MUC5AC and gastric transcription factor SOX2 in ampulla of vater adenocarcinoma: comparison between expression patterns and histologic subtypes. Oncol Rep; 2006 May;15(5):1157-61
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  • [Title] Expression of gastric mucin MUC5AC and gastric transcription factor SOX2 in ampulla of vater adenocarcinoma: comparison between expression patterns and histologic subtypes.
  • The purpose of this study was to examine the expression pattern of MUC5AC and SOX2 in ampulla of vater adenocarcinoma and evaluate the association between expression of these gastric epithelial markers and the histologic phenotype of ampulla of vater carcinoma.
  • Six surgically resected samples of ampulla of vater adenocarcinoma, including four intestinal type carcinomas and two pancreatobiliary type carcinomas, were studied.
  • [MeSH-major] Adenocarcinoma / metabolism. Ampulla of Vater / metabolism. Common Bile Duct Neoplasms / metabolism. HMGB Proteins / metabolism. Mucins / metabolism. Pancreatic Neoplasms / metabolism. Stomach Neoplasms / metabolism. Transcription Factors / metabolism
  • [MeSH-minor] Aged. Aged, 80 and over. Bile Ducts, Intrahepatic / metabolism. Bile Ducts, Intrahepatic / pathology. Carcinoma, Pancreatic Ductal / metabolism. Carcinoma, Pancreatic Ductal / pathology. Female. Humans. Intestinal Neoplasms / metabolism. Intestinal Neoplasms / pathology. Lymphatic Metastasis. Male. Middle Aged. Mucin 5AC. Neoplasm Invasiveness. SOXB1 Transcription Factors

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  • (PMID = 16596179.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / HMGB Proteins; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucins; 0 / SOX2 protein, human; 0 / SOXB1 Transcription Factors; 0 / Transcription Factors
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71. Park I, Lee JL, Ryu MH, Kim TW, Chang HM, Lee SS, Sohn BS, Kim EK, Park DH, Lee SS, Suh DW, Lee SK, Kim MH, Lee J: Efficacy and safety of S-1 monotherapy in patients with advanced biliary tract adenocarcinoma: retrospective analysis of 162 patients. Oncology; 2009;76(2):126-32

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  • [Title] Efficacy and safety of S-1 monotherapy in patients with advanced biliary tract adenocarcinoma: retrospective analysis of 162 patients.
  • AIM: We investigated the efficacy and safety of S-1 monotherapy for the treatment of advanced biliary tract adenocarcinoma (BTA) in a clinical practice setting.
  • The primary tumors were intrahepatic (n = 57), in the gall bladder (n = 50), in extrahepatic bile ducts (n = 41) and in the ampulla of Vater (n = 14).
  • Response rates and survival differed significantly according to the primary site of the tumor (p = 0.002 and p < 0.001, respectively), with extrahepatic bile duct adenocarcinoma having the best prognosis.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Biliary Tract Neoplasms / drug therapy. Oxonic Acid / therapeutic use. Tegafur / therapeutic use

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  • (PMID = 19158445.001).
  • [ISSN] 1423-0232
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid
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72. Yamamoto M, Otsubo T, Ariizumi S, Nakano M, Takasaki K: Intrahepatic cholangiocarcinoma detected by elevated levels of alpha-fetoprotein-L3 after hepatectomy for hepatocellular carcinoma in a patient with Budd-Chiari syndrome. Int Surg; 2005 Apr-Jun;90(2):81-4
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  • [Title] Intrahepatic cholangiocarcinoma detected by elevated levels of alpha-fetoprotein-L3 after hepatectomy for hepatocellular carcinoma in a patient with Budd-Chiari syndrome.
  • We report the case of a 57-year-old woman with Budd-Chiari syndrome, hepatocellular carcinoma (HCC), and intrahepatic cholangiocarcinoma (ICC).
  • Microscopic examination showed that tubular adenocarcinoma and immunohistochemical staining was focally positive for AFP.
  • [MeSH-major] Bile Duct Neoplasms / blood. Bile Ducts, Intrahepatic. Carcinoma, Hepatocellular / surgery. Cholangiocarcinoma / blood. Liver Neoplasms / surgery. alpha-Fetoproteins / analysis
  • [MeSH-minor] Budd-Chiari Syndrome / complications. Budd-Chiari Syndrome / diagnosis. Female. Hepatectomy / adverse effects. Humans. Middle Aged


73. Higuchi R, Yamamoto M, Hatori T, Shimizu K, Imai K, Takasaki K: Intrahepatic cholangiocarcinoma with lymph node metastasis successfully treated by immunotherapy with CD3-activated T cells and dendritic cells after surgery: report of a case. Surg Today; 2006;36(6):559-62
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  • [Title] Intrahepatic cholangiocarcinoma with lymph node metastasis successfully treated by immunotherapy with CD3-activated T cells and dendritic cells after surgery: report of a case.
  • Intrahepatic cholangiocarcinoma (ICC) with lymph node (LN) metastasis is generally associated with a poor prognosis.
  • Pathological examination confirmed a diagnosis of moderately differentiated adenocarcinoma with LN metastasis and portal vein invasion.
  • [MeSH-major] Adenocarcinoma / therapy. Antigens, CD3 / immunology. Bile Duct Neoplasms / therapy. Bile Ducts, Intrahepatic. Cholangiocarcinoma / therapy. Dendritic Cells / immunology. Immunotherapy / methods. T-Lymphocytes / immunology

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  • (PMID = 16715430.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, CD3
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74. Ali CW, Kaye TF, Adamson DJ, Tait IS, Polignano FM, Highley MS: CA 19-9 and survival in advanced and unresectable pancreatic adenocarcinoma and cholangiocarcinoma. J Gastrointest Cancer; 2007;38(2-4):108-14
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  • [Title] CA 19-9 and survival in advanced and unresectable pancreatic adenocarcinoma and cholangiocarcinoma.
  • BACKGROUND: The CA 19-9 tumour marker is increasingly used to monitor response to therapy in patients with pancreatic adenocarcinoma.
  • AIM OF STUDY: To assess the utility of CA 19-9 levels in the management of patients with advanced pancreatic adenocarcinoma or cholangiocarcinoma in routine clinical practice is the aim of the study.
  • METHODS: A retrospective analysis of CA 19-9 values and survival was performed in 26 patients with pancreatic adenocarcinoma receiving gemcitabine and in 18 patients with cholangiocarcinoma.
  • RESULTS: Patients with advanced pancreatic adenocarcinoma receiving gemcitabine who experienced a decrease of > or = 20% in CA 19-9 concentration had a median survival of 13.9+ months (range 4.2-23.5) compared to 7.6+ months (range 4.0-14.7) in those without such a change (p = 0.0109).
  • CONCLUSIONS: The CA 19-9 concentration has a valuable role in predicting outcome in patients with pancreatic adenocarcinoma and cholangiocarcinoma.
  • [MeSH-major] Adenocarcinoma / mortality. Bile Duct Neoplasms / mortality. CA-19-9 Antigen / blood. Cholangiocarcinoma / mortality. Pancreatic Neoplasms / mortality
  • [MeSH-minor] Aged. Aged, 80 and over. Antimetabolites, Antineoplastic / therapeutic use. Bile Ducts, Intrahepatic / pathology. Biomarkers, Tumor / blood. Deoxycytidine / analogs & derivatives. Deoxycytidine / therapeutic use. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 19089662.001).
  • [ISSN] 1941-6628
  • [Journal-full-title] Journal of gastrointestinal cancer
  • [ISO-abbreviation] J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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75. Cereda S, Passoni P, Reni M, Viganò MG, Aldrighetti L, Nicoletti R, Villa E: The cisplatin, epirubicin, 5-fluorouracil, gemcitabine (PEFG) regimen in advanced biliary tract adenocarcinoma. Cancer; 2010 May 1;116(9):2208-14
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  • [Title] The cisplatin, epirubicin, 5-fluorouracil, gemcitabine (PEFG) regimen in advanced biliary tract adenocarcinoma.
  • BACKGROUND: Biliary tract adenocarcinoma (BTA) is an uncommon tumor with a poor prognosis and no standard, systemic chemotherapy.
  • METHODS: PEFG (cisplatin 40 mg/m(2) and epirubicin 40 mg/m(2) on Day 1; gemcitabine 600 mg/m(2) on Days 1 and 8; and 5-fluorouracil [FU] 200 mg/m(2) daily as a continuous infusion) was administered to chemotherapy-naive patients who had a cytologic or histologic diagnosis of locally advanced or metastatic BTA, aged <or=75 years, and a performance status (PS) >60 either until they had evidence progressive disease or for a maximum of 6 months.
  • Primary tumor sites were the intrahepatic bile duct in 10 patients (27%), the extrahepatic bile duct in 8 patients (22%), the gallbladder in 12 patients (32%), and the ampulla of Vater in 7 patients (19%).
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biliary Tract Neoplasms / drug therapy

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  • [Copyright] (c) 2010 American Cancer Society.
  • (PMID = 20187098.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; 3Z8479ZZ5X / Epirubicin; B76N6SBZ8R / gemcitabine; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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76. Jarnagin WR, Klimstra DS, Hezel M, Gonen M, Fong Y, Roggin K, Cymes K, DeMatteo RP, D'Angelica M, Blumgart LH, Singh B: Differential cell cycle-regulatory protein expression in biliary tract adenocarcinoma: correlation with anatomic site, pathologic variables, and clinical outcome. J Clin Oncol; 2006 Mar 1;24(7):1152-60
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  • [Title] Differential cell cycle-regulatory protein expression in biliary tract adenocarcinoma: correlation with anatomic site, pathologic variables, and clinical outcome.
  • Tumor sites of origin were intrahepatic cholangiocarcinoma (IH; n = 23), hilar cholangiocarcinoma (Hilar; n = 54), gallbladder (GB; n = 32), and distal bile duct (Distal; n = 19).
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic. Biomarkers, Tumor / analysis. Cell Cycle Proteins / analysis. Cholangiocarcinoma / pathology. Gallbladder Neoplasms / pathology

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  • (PMID = 16505435.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDKN1A protein, human; 0 / Cell Cycle Proteins; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Ki-67 Antigen; 0 / Proliferating Cell Nuclear Antigen; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; 0 / p27 antigen; 136601-57-5 / Cyclin D1; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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77. Maâouni S, Benaddi L, Kabbaj N, Errabih I, Alhamany Z, Benaïssa A: [Krukenberg tumor: rare metastasis of hilar cholangiocarcinoma]. Presse Med; 2006 Jul-Aug;35(7-8):1181-4
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  • Hepatobiliary ultrasound showed dilatation of the intrahepatic bile ducts.
  • Surgery discovered an extensive unresectable tumor of the proximal principal bile duct.
  • The histology study found adenocarcinoma of the bile duct, and concluded that the Krukenberg tumor was secondary to this cholangiocarcinoma.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic. Cholangiocarcinoma / pathology. Krukenberg Tumor / secondary. Ovarian Neoplasms / secondary
  • [MeSH-minor] Adenocarcinoma / pathology. Female. Humans. Middle Aged. Neoplasm Metastasis. Tomography, X-Ray Computed

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  • (PMID = 16840896.001).
  • [ISSN] 0755-4982
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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78. Byun JH: [Radiological staging of hilar cholangiocarcinoma]. Korean J Gastroenterol; 2005 Jul;46(1):7-15
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  • Hilar cholangiocarcinoma is an adenocarcinoma arising from the bile duct epithelium, at the confluence of the right and left intrahepatic bile ducts, within the porta hepatis.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic. Cholangiocarcinoma / diagnosis

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  • (PMID = 16030398.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Journal Article; Review
  • [Publication-country] Korea (South)
  • [Number-of-references] 22
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79. Lewis JT, Talwalkar JA, Rosen CB, Smyrk TC, Abraham SC: Prevalence and risk factors for gallbladder neoplasia in patients with primary sclerosing cholangitis: evidence for a metaplasia-dysplasia-carcinoma sequence. Am J Surg Pathol; 2007 Jun;31(6):907-13
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  • Dysplasia, adenomas, and carcinomas of the gallbladder have been described in PSC but are less common than bile duct carcinomas.
  • We evaluated the following histologic features: presence of diffuse lymphoplasmacytic chronic cholecystitis, pyloric metaplasia, intestinal metaplasia, dysplasia (low-grade or high-grade), and adenocarcinoma.
  • Gallbladder dysplasia and adenocarcinoma were correlated with several clinicopathologic parameters using Fisher exact test and t test, including:.
  • (1) sex, (2) age, (3) PSC duration, (4) inflammatory bowel disease (IBD) at time of OLT, and (5) concomitant bile duct dysplasia or carcinoma.
  • Lymphoplasmacytic chronic cholecystitis was present in 35 (49%), pyloric metaplasia in 69 (96%), intestinal metaplasia in 36 (50%), dysplasia in 27 (37%; low-grade in 12 and high-grade in 15), and adenocarcinoma in 10 (14%; 2 with lamina propria invasion and 8 with invasion into muscularis or adventitia).
  • Gallbladder carcinoma was associated with intrahepatic bile duct dysplasia (P=0.001), CC (P=0.023), and IBD (P=0.03).
  • Gallbladder dysplasia was associated with hilar/intrahepatic bile duct dysplasia (P=0.0006), CC (P=0.028), IBD (P=0.0014), and older age at OLT (P=0.007).
  • The strong correlation between gallbladder dysplasia/adenocarcinoma and bile duct dysplasia/CC supports the concept of a neoplastic "field effect" along the intrahepatic and extrahepatic biliary tract in PSC.
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenocarcinoma / etiology. Cholangitis, Sclerosing / complications. Gallbladder Neoplasms / epidemiology. Gallbladder Neoplasms / etiology
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Bile Duct Neoplasms / pathology. Bile Ducts / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / pathology. Female. Humans. Liver Transplantation. Male. Middle Aged. Neoplasms, Multiple Primary / pathology. Precancerous Conditions / epidemiology. Precancerous Conditions / pathology. Prevalence. Risk Factors

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  • (PMID = 17527079.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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80. Gütgemann I, Haas S, Berg JP, Zhou H, Büttner R, Fischer HP: CD56 expression aids in the differential diagnosis of cholangiocarcinomas and benign cholangiocellular lesions. Virchows Arch; 2006 Apr;448(4):407-11
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  • [Title] CD56 expression aids in the differential diagnosis of cholangiocarcinomas and benign cholangiocellular lesions.
  • In this study, we systematically examined CD56 expression on 98 tumours arising from the biliary tree as well as intrahepatic conditions with reactive neoductules.
  • Reactive bile ductules adjacent to cirrhotic nodules as well as in focal nodular hyperplasia were CD56 positive.
  • Twelve of 17 (70.5%) bile duct adenomas were CD56 positive, whereas von Meyenburg complexes expressed CD56 only very focally in less than 5% of lesional cells.
  • Bile duct cysts were negative for CD56 with the exception of focally interspersed neuroendocrine cells, similar to that seen in segmental bile ducts.
  • Thus, if van Meyenburg complexes are excluded, CD56 can be used to differentiate intrahepatic non-neoplastic from neoplastic proliferations, which is a helpful diagnostic tool in small liver biopsies.
  • [MeSH-major] Antigens, CD56 / metabolism. Bile Duct Neoplasms / metabolism. Bile Ducts, Intrahepatic / metabolism. Biomarkers, Tumor / metabolism. Cholangiocarcinoma / metabolism. Cholangitis / metabolism
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / metabolism. Adenoma, Bile Duct / diagnosis. Adenoma, Bile Duct / metabolism. Bile Ducts, Extrahepatic / metabolism. Bile Ducts, Extrahepatic / pathology. Choledochal Cyst / diagnosis. Choledochal Cyst / metabolism. Cystadenoma, Mucinous / diagnosis. Cystadenoma, Mucinous / metabolism. Diagnosis, Differential. Humans. Immunohistochemistry. Liver Cirrhosis / diagnosis. Liver Cirrhosis / metabolism

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  • (PMID = 16411132.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / Biomarkers, Tumor
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81. Nakazawa K, Dobashi Y, Suzuki S, Fujii H, Takeda Y, Ooi A: Amplification and overexpression of c-erbB-2, epidermal growth factor receptor, and c-met in biliary tract cancers. J Pathol; 2005 Jul;206(3):356-65
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  • Overexpression of the tyrosine kinase receptor proteins was examined by immunohistochemistry in 221 biliary tract carcinomas, of which 28 were from the intrahepatic bile duct, 78 from the extrahepatic bile duct, 89 from the gall bladder, and 26 from the ampulla of Vater.
  • Overexpression of ErbB-2 was found in 15.7%, 11.5%, and 5.1% of carcinomas of the gall bladder, ampulla of Vater, and extrahepatic bile duct, respectively, and gene amplification was present in 79% of these.
  • Met overexpression, most frequent in intrahepatic bile duct carcinomas (21.4%), was not associated with gene amplification.
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Ampulla of Vater / pathology. Bile Duct Neoplasms / genetics. Bile Duct Neoplasms / pathology. Bile Ducts, Extrahepatic / pathology. Bile Ducts, Intrahepatic / pathology. Common Bile Duct Neoplasms / genetics. Common Bile Duct Neoplasms / pathology. Female. Gallbladder Neoplasms / genetics. Gallbladder Neoplasms / pathology. Gene Amplification / genetics. Gene Expression Regulation, Neoplastic / genetics. Humans. Immunohistochemistry / methods. In Situ Hybridization, Fluorescence / methods. Lymph Nodes / pathology. Male. Middle Aged. Neoplasm Proteins / genetics

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  • [Copyright] Copyright 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
  • (PMID = 15892172.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; EC 2.7.10.1 / Proto-Oncogene Proteins c-met; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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82. Slattery JM, Sahani DV: What is the current state-of-the-art imaging for detection and staging of cholangiocarcinoma? Oncologist; 2006 Sep;11(8):913-22
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  • Cholangiocarcinoma is an adenocarcinoma that arises from the bile duct epithelium and is the second most common primary hepatobiliary cancer, after hepatocellular cancer, with approximately 2,500 cases annually in the U.S.
  • The median survival time for patients with intrahepatic cholangiocarcinoma without involvement of the hilum varies among centers from 18-30 months.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic. Cholangiocarcinoma / diagnosis

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  • (PMID = 16951395.001).
  • [ISSN] 1083-7159
  • [Journal-full-title] The oncologist
  • [ISO-abbreviation] Oncologist
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 56
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83. Boberg KM, Jebsen P, Clausen OP, Foss A, Aabakken L, Schrumpf E: Diagnostic benefit of biliary brush cytology in cholangiocarcinoma in primary sclerosing cholangitis. J Hepatol; 2006 Oct;45(4):568-74
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  • METHODS: In this prospective case series we obtained brush cytology specimens from bile duct strictures in 61 consecutive PSC patients.
  • The cytological classifications were compared with histopathological findings in bile ducts from explanted livers or clinical outcome.
  • RESULTS: Among patients with cytological low-grade (n=9; 15%) or high-grade dysplasia/adenocarcinoma (n=13; 21%), 8 (36%) proved to have cholangiocarcinoma and 7 (32%) to have high-grade dysplasia (i.e. cholangiocarcinoma in situ) in bile ducts from explanted livers.
  • The sensitivity, specificity, positive- and negative predictive values, and accuracy of brush cytology in diagnosis of biliary malignancy were 100%, 84%, 68%, 100%, and 88% for the combination of low-grade and high-grade dysplasia/adenocarcinoma and 73%, 95%, 85%, 91%, and 90% for high-grade dysplasia/adenocarcinoma only.
  • All patients with high-grade biliary epithelial dysplasia in explanted bile ducts were tumour free at follow-up.
  • CONCLUSIONS: Brush cytology from bile duct strictures in PSC patients can detect cholangiocarcinoma in situ.
  • Patients with cytological low-grade and high-grade dysplasia/adenocarcinoma are currently referred for liver transplantation in our hospital.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Biopsy / methods. Cholangiocarcinoma / pathology. Cholangitis, Sclerosing / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adolescent. Adult. Aged. Biomarkers, Tumor. Carcinoma in Situ / pathology. Cholangiopancreatography, Endoscopic Retrograde. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Prospective Studies. Sensitivity and Specificity

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  • [CommentIn] J Hepatol. 2006 Oct;45(4):476-9 [16901574.001]
  • (PMID = 16879890.001).
  • [ISSN] 0168-8278
  • [Journal-full-title] Journal of hepatology
  • [ISO-abbreviation] J. Hepatol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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84. Tischoff I, Wittekind C, Tannapfel A: Role of epigenetic alterations in cholangiocarcinoma. J Hepatobiliary Pancreat Surg; 2006;13(4):274-9
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  • Intrahepatic cholangiocarcinomas are rare malignant epithelial liver tumors arising from intrahepatic bile ducts.
  • [MeSH-major] Bile Duct Neoplasms / genetics. Bile Ducts, Intrahepatic. Cholangiocarcinoma / genetics. Epigenesis, Genetic
  • [MeSH-minor] Adenocarcinoma / genetics. Apoptosis / genetics. Bile Ducts, Extrahepatic / pathology. Cell Adhesion / physiology. Cell Proliferation. Cell Transformation, Neoplastic / genetics. CpG Islands / genetics. DNA Methylation. DNA Repair / physiology. Genes, Tumor Suppressor / physiology. Humans

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  • (PMID = 16858537.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 68
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85. Okabe Y, Kuwaki K, Kawano H, Kaji R, Sugiyama G, Ishida Y, Yasumoto M, Naito Y, Toyonaga A, Tsuruta O, Sata M: Direct cholangioscopy using a double-balloon enteroscope: choledochojejunostomy with intraductal biliary carcinoma. Dig Endosc; 2010 Oct;22(4):319-21
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  • Abdominal computed tomography revealed marked dilation of the intrahepatic bile duct in the right lobe and an image of a hypervascular tumor.
  • Endoscopic retrograde cholangiography using double-balloon enteroscopy (DBE) showed a filling defect that was localized to the right hepatic bile duct.
  • Furthermore, the scope was able to readily pass through the anastomosed site of the choledochojejunostomy and, therefore, we observed the interior of the bile duct using the same scope.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic. Carcinoma, Papillary / diagnosis

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  • [Copyright] © 2010 The Authors. Digestive Endoscopy © 2010 Japan Gastroenterological Endoscopy Society.
  • (PMID = 21175487.001).
  • [ISSN] 1443-1661
  • [Journal-full-title] Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
  • [ISO-abbreviation] Dig Endosc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Contrast Media
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86. Choi SC, Lee JK, Jung JH, Lee JS, Lee KH, Lee KT, Rhee JC, Jang KT, Choi SH, Heo JS, Choi DW, Lim JH: The clinicopathological features of biliary intraductal papillary neoplasms according to the location of tumors. J Gastroenterol Hepatol; 2010 Apr;25(4):725-30
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  • We divided them into three groups: common bile duct (CBD), hilar, and intrahepatic duct (IHD) groups.
  • [MeSH-major] Adenocarcinoma / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Common Bile Duct Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Mucinous / mortality. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / secondary. Adenocarcinoma, Mucinous / therapy. Adult. Aged. Chi-Square Distribution. Cholangiopancreatography, Endoscopic Retrograde. Cholangiopancreatography, Magnetic Resonance. Female. Gallstones / pathology. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Neoplasm Staging. Republic of Korea. Time Factors. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 20492329.001).
  • [ISSN] 1440-1746
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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87. Ono S, Fumino S, Shimadera S, Iwai N: Long-term outcomes after hepaticojejunostomy for choledochal cyst: a 10- to 27-year follow-up. J Pediatr Surg; 2010 Feb;45(2):376-8

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  • INTRODUCTION: Choledochal cyst (CC) is closely associated with anomalous arrangement of the pancreaticobiliary duct, which is considered a high-risk factor for biliary tract malignancy.
  • Early diagnosis and early treatment for CC could lead to a good prognosis.
  • All patients had undergone total resection of the extrahepatic bile duct and hepaticojejunostomy.
  • Dilatation of intrahepatic bile ducts persisted in 6 postoperatively, and in 3, this was still apparent more than 10 years after.
  • A 14-year-old girl died of recurrent common bile duct cancer 2 years after the initial resection of CC with adenocarcinoma.
  • A 26-year-old man with repeated cholangitis owing to multiple intrahepatic bile stones developed cholangiocarcinoma 26 years after the initial resection of CC.
  • Long-term surveillance for the development of malignancy is still essential, especially if there is ongoing dilatation of the intrahepatic bile duct or biliary stones.
  • [MeSH-minor] Adolescent. Adult. Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic / surgery. Biliary Tract Surgical Procedures / methods. Cholangiocarcinoma / surgery. Common Bile Duct / surgery. Dilatation, Pathologic / surgery. Disease-Free Survival. Female. Follow-Up Studies. Humans. Longitudinal Studies. Male. Prognosis. Retrospective Studies. Treatment Outcome

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20152355.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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88. Adachi S, Morimoto O, Kobayashi T: Lymphoepithelioma-like cholangiocarcinoma not associated with EBV. Pathol Int; 2008 Jan;58(1):69-74
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  • Reported herein is an unusual case of intrahepatic cholangiocarcinoma with lymphoepithelioma-like appearance in a 64-year-old man who was found to have an intrahepatic mass without cirrhosis.
  • The first was similar to nasopharyngeal undifferentiated carcinoma; the second pattern was a well-differentiated adenocarcinoma.
  • Transition between the two components was observed in the same duct.
  • Intrahepatic lymphoepithelioma-like carcinoma is rare, and most are associated with EBV.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Carcinoma / pathology. Cholangiocarcinoma / pathology. Herpesvirus 4, Human

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  • (PMID = 18067645.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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89. Kawate S, Ohwada S, Ikota H, Hamada K, Kashiwabara K, Morishita Y: Xanthogranulomatous cholangitis causing obstructive jaundice: a case report. World J Gastroenterol; 2006 Jul 21;12(27):4428-30

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  • Microscopically, the bile duct was surrounded and narrowed by a xanthogranulomatous lesion, but no xanthogranulomatous cholecystitis was seen.
  • Although percutaneous cholangiograms done via the transhepatic biliary drainage showed smooth narrowing of the upper to middle bile duct, the cytology of bile was diagnosed as class V adenocarcinoma.
  • Therefore, right extended hepatectomy and extrahepatic bile duct resection were performed.
  • Xanthogranulomatous cholangitis is one possible diagnosis of a bile duct stricture.
  • Precise review of all the preoperative information is required to make a correct diagnosis.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adult. Bile Duct Neoplasms / diagnosis. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Diagnosis, Differential. Female. Humans

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  • [Cites] Br J Surg. 2001 Jan;88(1):48-51 [11136309.001]
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  • (PMID = 16865792.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4087761
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90. Goodman ZD: Neoplasms of the liver. Mod Pathol; 2007 Feb;20 Suppl 1:S49-60
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  • Cholangiocarcinoma, a primary adenocarcinoma that arises from a bile duct, is second in frequency.
  • Cholangiocarcinoma resembles adenocarcinomas arising in other tissues, so a definitive diagnosis relies on the exclusion of an extrahepatic primary and distinction from benign biliary lesions.
  • [MeSH-minor] Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / diagnosis. Diagnosis, Differential. Female. Humans. Male

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  • (PMID = 17486052.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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91. Takahashi Y, Kawate S, Watanabe M, Fukushima J, Mori S, Fukusato T: Amplification of c-myc and cyclin D1 genes in primary and metastatic carcinomas of the liver. Pathol Int; 2007 Jul;57(7):437-42
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  • In the present study, c-myc and cyclin D1 gene amplification was examined in 76 primary and metastatic liver carcinomas using formalin-fixed paraffin-embedded tissue sections and a differential polymerase chain reaction procedure. c-myc and cyclin D1 gene amplification was detected in 15 (33%) and two (4%) of 46 hepatocellular carcinomas (HCC), one (10%) and 0 (0%) of 10 intrahepatic cholangiocarcinomas (ICC), one (33%) and 0 (0%) of three combined hepatocellular and cholangiocarcinomas (HCC + ICC), and nine (56%) and three (19%) of 16 metastatic lesions to the liver from colorectal adenocarcinoma (MCA), respectively.
  • [MeSH-major] Adenocarcinoma / genetics. Cyclins / genetics. Gene Amplification. Liver Neoplasms / genetics. Proto-Oncogene Proteins c-myc / genetics
  • [MeSH-minor] Bile Duct Neoplasms / genetics. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Carcinoma, Hepatocellular / genetics. Carcinoma, Hepatocellular / secondary. Cholangiocarcinoma / genetics. Cholangiocarcinoma / secondary. Colorectal Neoplasms / genetics. Colorectal Neoplasms / pathology. Cyclin D. Humans. In Situ Hybridization, Fluorescence. Neoplasms, Multiple Primary. Polymerase Chain Reaction

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  • (PMID = 17587243.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Cyclin D; 0 / Cyclins; 0 / MYC protein, human; 0 / Proto-Oncogene Proteins c-myc
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92. Kuroki T, Fukuda K, Tajima Y, Matsuzaki S, Kitajima T, Furui J, Kanematsu T: Parapapillary choledochoduodenal fistula associated with cholangiocarcinoma. J Hepatobiliary Pancreat Surg; 2005;12(2):143-6
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  • She had no clinical symptoms, but computed tomography scans showed an irregularly contoured liver tumor which was histologically confirmed to be adenocarcinoma, by a needle biopsy examination.
  • Duodenal fiberscopy revealed a fistula orifice 1.0 cm proximal to the orifice of the papilla of Vater, and endoscopic retrograde cholangiography through the fistula showed a communication to the common bile duct.
  • The bile sample collected from the common bile duct showed extremely high levels of pancreatic enzymes, including amylase, phospholipase-A2, and elastase-I.
  • Furthermore, Helicobacter DNA was detected in bile by polymerase chain reaction (PCR) analysis.
  • [MeSH-major] Bile Duct Neoplasms / etiology. Bile Ducts, Intrahepatic. Biliary Fistula / complications. Cholangiocarcinoma / etiology. Common Bile Duct Diseases / complications. Duodenal Diseases / complications. Intestinal Fistula / complications
  • [MeSH-minor] Adenocarcinoma / etiology. Ampulla of Vater. Amylases / analysis. Bile / microbiology. Female. Helicobacter pylori / isolation & purification. Humans. Middle Aged. Risk Factors

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  • (PMID = 15868079.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] EC 3.2.1.- / Amylases
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93. Trivedi PJ, Gupta P, Phillips-Hughes J, Ellis A: Biloma: an unusual complication in a patient with pancreatic cancer. World J Gastroenterol; 2009 Nov 7;15(41):5218-20
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  • The term biloma describes an encapsulated collection of bile within the abdomen, usually secondary to bile duct disruption.
  • We report the case of a 64-year-old man initially diagnosed with a non-obstructive malignancy of the pancreas, who developed a spontaneous intrahepatic biloma 8 mo later.
  • Forty-eight hours later, a stent was inserted endoscopically into his common bile duct and he made an uneventful in-hospital recovery.
  • We believe this is the first documented case of spontaneous intrahepatic biloma to occur secondary to pancreatic malignancy.
  • [MeSH-major] Adenocarcinoma / complications. Bile / metabolism. Bile Duct Diseases / etiology. Bile Duct Diseases / metabolism. Bile Ducts, Intrahepatic / metabolism. Pancreatic Neoplasms / complications

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  • [Copyright] 2009 The WJG Press and Baishideng. All rights reserved.
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  • (PMID = 19891023.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2773903
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94. Onodera S, Saito K, Saito T, Togashi H, Kawata S, Ukai K, Shinzawa H: [Clonorchiasis complicated with duodenal papillary cancer in a visitor from China]. Nihon Shokakibyo Gakkai Zasshi; 2007 Feb;104(2):213-8
MedlinePlus Health Information. consumer health - Intestinal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It is well known that long-term infection with Clonorchis sinensis often causes bile duct cancer, usually.
  • It occurs in the intrahepatic bile duct.
  • Also, we reported that the microplate ELISA technique was useful in the diagnosis of clonorchiasis with high accuracy in this case.
  • [MeSH-major] Adenocarcinoma / etiology. Ampulla of Vater. Clonorchiasis / complications. Common Bile Duct Neoplasms / etiology. Duodenal Neoplasms / etiology

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  • (PMID = 17283416.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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95. Igami T, Yokoyama Y, Nishio H, Ebata T, Shimoyama Y, Nakamura S, Nagino M: Small pancreatic carcinoma misdiagnosed as superficially spreading cholangiocarcinoma. J Hepatobiliary Pancreat Surg; 2009;16(4):579-84
MedlinePlus Health Information. consumer health - Pancreatic Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • He was referred to our hospital with a diagnosis of superficially spreading cholangiocarcinoma.
  • Cholangiography revealed a stenosis of the common bile duct, and also revealed some irregularities from the common hepatic duct to the left hepatic duct, suggesting a superficial spread of cancer.
  • Cholangioscopy disclosed an elevated tumor with torsional vessels and granular mucosal lesions, which were extended to the left hepatic duct.
  • Repeated cholangioscopic biopsies of the bile duct mucosa revealed adenocarcinoma.
  • The patient was diagnosed with superficially spreading cholangiocarcinoma extending to the left hepatic duct and the right anterior hepatic duct.
  • Histological findings of the resected specimen revealed adenocarcinoma arising from the pancreatic head with invasion in the common bile duct.
  • Additionally, extensive inflammatory granulation tissue was observed along the surface of the bile duct, without any evidence of carcinoma.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic. Cholangiocarcinoma / diagnosis. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Aged. Common Bile Duct Neoplasms / diagnosis. Humans. Male

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  • (PMID = 19259611.001).
  • [ISSN] 1436-0691
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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96. Lee BK, Seo YH, Lee NH, Joo SY, Ko HM: [Cholangiocarcinoma with distant cutaneous metastases]. Korean J Gastroenterol; 2009 Nov;54(5):342-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cholangiocarcinoma, a malignant cancer of the bile duct, is a relatively rare adenocarcinoma and has a poor prognosis.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic. Cholangiocarcinoma / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 19934617.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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97. Artifon EL, Rodrigues AZ, Marques S, Halwan B, Sakai P, Bresciani C, Kumar A: Laparoscopic deployment of biliary self-expandable metal stent (SEMS) for one-step palliation in 23 patients with advanced pancreatico-biliary tumors--a pilot trial. J Gastrointest Surg; 2007 Dec;11(12):1686-91
MedlinePlus Health Information. consumer health - Pancreatic Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Exploratory laparoscopy is commonly undertaken in patients with highly suspicious biliary and pancreatic lesions to facilitate diagnosis and staging cancer is present.
  • PATIENTS AND METHODS: A total of 23 eligible patients (8 male and 15 female) with malignant obstruction of the common bile duct underwent deployment of SEMS at laparoscopy.
  • RESULTS: Indications for stent deployment were unresectable pancreatic cancer in 18, cholangiocarcinoma in two, neuroendocrine tumor in one and ampullary adenocarcinoma in two patients.
  • The median size of the pancreatic mass was 3 cm (range 2-5 cm) and that of the common bile duct (CBD) from 9.2 mm (range 7.2-17.4).
  • CONCLUSION: This study demonstrates that laparoscopic deployment of self-expandable metal bile duct stents is feasible and safe.
  • This option appears to be a reasonable option in patients with inoperable malignant obstruction of the distal common bile duct.
  • [MeSH-major] Adenocarcinoma / surgery. Biliary Tract Neoplasms / surgery. Palliative Care. Pancreatic Neoplasms / surgery. Stents
  • [MeSH-minor] Aged. Aged, 80 and over. Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic / surgery. Cholangiocarcinoma / surgery. Feasibility Studies. Female. Fluoroscopy. Humans. Laparoscopy. Male. Middle Aged. Pilot Projects. Prosthesis Design

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  • (PMID = 17906909.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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98. Silva MA, Tekin K, Aytekin F, Bramhall SR, Buckels JA, Mirza DF: Surgery for hilar cholangiocarcinoma; a 10 year experience of a tertiary referral centre in the UK. Eur J Surg Oncol; 2005 Jun;31(5):533-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Extra hepatic bile duct resection was done in 14 patients of which four were R0 resections.
  • Thirty-one had bile duct resection including partial hepatectomy with 19 R0 resections (P=0.042).
  • Median survival of patients who underwent liver resection was longer than those with bile duct resection only (30 vs 24 months P=0.43: NS).
  • Clear histological margins were associated with improved survival and were better achieved by liver resection as compared to extra hepatic bile duct resection.
  • [MeSH-major] Adenocarcinoma / surgery. Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic. Cholangiocarcinoma / surgery

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  • (PMID = 15922889.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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99. Dumitrascu T, Ionescu M, Ciurea S, Herlea V, Lupescu I, Popescu I: Klatskin-mimicking lesions--a case series and literature review. Hepatogastroenterology; 2010 Jul-Aug;57(101):961-7
MedlinePlus Health Information. consumer health - Bile Duct Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Obstruction of the hepatic hilum in patients without prior surgery is generally due to hilar adenocarcinoma (Klatskin tumor).
  • Although uncommon, benign strictures of the proximal bile duct should be taken into consideration in differential diagnosis of Klatskin tumors, since the incidence could reach up to 25% of patients with presumed Klatskin tumor diagnosis.
  • This group of benign proximal bile duct strictures (Klatskin-mimicking lesions) is usually represented by segmental fibrosis and non-specific chronic inflammation.
  • Herein, we present a case series of three patients with benign proximal bile duct strictures (representing 4.1% of 73 patients resected with presumptive preoperative diagnosis of Klatskin tumor) and literature review.
  • However, despite new diagnosis tools developed in the last years, patients with hilar obstructions still require unnecessary extensive resections due to impossibility of excluding the malignancy.
  • In all cases of proximal bile duct obstruction presumed malignant, they should be managed accordingly, even with the risk of over-treatment for some benign lesions.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Hepatic Duct, Common. Klatskin Tumor / diagnosis
  • [MeSH-minor] Adult. Bile Ducts, Intrahepatic / pathology. Cholangiopancreatography, Endoscopic Retrograde. Cholangiopancreatography, Magnetic Resonance. Cholestasis. Diagnosis, Differential. Dilatation, Pathologic. Humans. Magnetic Resonance Imaging. Male. Middle Aged

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  • (PMID = 21033260.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Greece
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100. Hiraki S, Matsukuma S, Nagashima A, Kawaoka T, Fukuda S: [A case of cholangiocellular carcinoma accompanied with peripheral blood eosinophilia which improved by removal of the hepatic tumor]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2801-3
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  • Needle biopsy of the hepatic tumor revealed an adenocarcinoma.
  • We performed left hepatectomy with lymph node dissection without a bile duct reconstruction.
  • The tumor was mass forming type accompanied with intra bile ductal growth in macroscopically.
  • Pathological diagnosis was cholangiocellular carcinoma.
  • [MeSH-major] Bile Duct Neoplasms / complications. Bile Ducts, Intrahepatic. Cholangiocarcinoma / complications. Eosinophilia / etiology

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  • (PMID = 21224718.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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