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[Title] Intraoperative radiofrequency ablation combined with 125 iodine seed implantation for unresectable pancreatic cancer.

AIM: To evaluate the feasibility, efficacy and safety of intraoperative radiofrequency ablation (RFA) combined with (125)iodine seed implantation for unresectable pancreatic cancer.

METHODS: Thirty-two patients (21 males and 11 females) at the age of 68 years (range 48-90 years) with unresectable locally advanced pancreatic cancer admitted to our hospital from January 2006 to May 2008 were enrolled in this study.

The tumor, 4-12 cm in diameter, located in pancreatic head of 23 patients and in pancreatic body and tail of 9 patients, was found to be unresectable during operation.

Diagnosis of pancreatic cancer was made through intraoperative biopsy.

CONCLUSION: Intraoperative RFA combined with (125)iodine seed implantation is a feasible and safe procedure for unresectable pancreatic cancer with acceptable minor complications, and can prolong the survival time of patients, especially those at stage III.

[MeSH-major] Adenocarcinoma / therapy. Catheter Ablation / methods. Iodine Radioisotopes / therapeutic use. Pancreatic Neoplasms / therapy. Radiotherapy / methods

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(PMID = 20976848.001).

[ISSN] 2219-2840

[Journal-full-title] World journal of gastroenterology

[ISO-abbreviation] World J. Gastroenterol.

[Language] eng

[Publication-type] Evaluation Studies; Journal Article

[Publication-country] China

[Chemical-registry-number] 0 / Iodine Radioisotopes

[Other-IDs] NLM/ PMC2965288

   

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[Title] [Treatment of pancreatic cancer--surgical point of view].

Although surgical techniques for pancreatic cancer have developed in a high level, the treatment results have not been improved and the 5 year survival rates after curative operation has been about 15% in Japan.

Retrospective studies on extended lymphadenectomy for ductal adenocarcinoma of the head of the pancreas revealed that extended surgery prolonged the survival for resected patients.

Finally, the clinical advantages of extended lymphadenectomy for pancreatic cancer was denied by several RCTs from Italy and U.S.A.

Further development of multidisciplinary treatments for pancreatic cancer is expected.

[MeSH-major] Carcinoma, Pancreatic Ductal / surgery. Lymph Node Excision / methods. Pancreatectomy. Pancreatic Neoplasms / surgery

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(PMID = 17637533.001).

[ISSN] 0385-0684

[Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy

[ISO-abbreviation] Gan To Kagaku Ryoho

[Language] jpn

[Publication-type] English Abstract; Journal Article; Review

[Publication-country] Japan

[Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine

[Number-of-references] 24

   

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[Title] Rectal cancer metastasis to the head of the pancreas treated with pancreaticoduodenectomy.

We report a case of a 50-year-old man who developed metastatic pancreatic cancer from a primary rectal cancer that had been curatively removed 3 years previously.

The patient presented with a tumor that occupied the head of the pancreas, associated with obstructive jaundice, but the main pancreatic duct was not dilated.

The patient was initially diagnosed as having primary pancreatic cancer.

Cytological examination of the bile was conclusive for the presence of adenocarcinoma.

For 1 year, local disease progression was slow and no distant metastases developed; therefore, the initial diagnosis of pancreatic cancer was questioned.

On histology, including immunohistochemical staining for cytokeratin 20 (positive) and cytokeratin 7 (negative), the tumor was shown to be a metastatic pancreatic carcinoma that had originated from the original rectal cancer.

[MeSH-major] Pancreatic Neoplasms / secondary. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy. Rectal Neoplasms / pathology

[MeSH-minor] Angiography. Cholangiopancreatography, Magnetic Resonance. Diagnosis, Differential. Fatal Outcome. Humans. Immunohistochemistry. Male. Middle Aged

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(PMID = 18040627.001).

[ISSN] 0944-1166

[Journal-full-title] Journal of hepato-biliary-pancreatic surgery

[ISO-abbreviation] J Hepatobiliary Pancreat Surg

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Japan

   

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[Title] A patient with nonfunctional pancreatic neuroendocrine tumor and incidental metachronous colon carcinoma detected by positron emission tomography: case report.

Pancreatic neuroendocrine tumors constitute about 2% of all gastrointestinal neoplasms.

Approximately half of the pancreatic euroendocrine tumors are nonfunctional.

Due to lack of specific symptoms, most patients with nonfunctional pancreatic neuroendocrine tumors present with locally advanced or metastatic disease.

Colon carcinoma ranks third in frequency among primary sites of cancer in both men and women in western countries.

Presence of a metachronous colon adenocarcinoma in a patient with nonfunctional pancreatic neuroendocrine tumor has not been reported before.

We present a patient who had an asymptomatic mass in the head of the pancreas, detected by ultrasonography in 1996.

In 2002, after the diagnosis of an unresectable, nonfunctional pancreatic neuroendocrine tumor, interferon alpha- 2b and octreotide were started.

[MeSH-major] Adenocarcinoma / radionuclide imaging. Colonic Neoplasms / radionuclide imaging. Neoplasms, Second Primary / radionuclide imaging. Neuroendocrine Tumors / radionuclide imaging. Pancreatic Neoplasms / radionuclide imaging. Positron-Emission Tomography

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(PMID = 19821205.001).

[ISSN] 2148-5607

[Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

[ISO-abbreviation] Turk J Gastroenterol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Turkey

   

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[Title] Inferior branch-preserving superior head resection of the pancreas with gastric wall-covering method for intraductal papillary mucinous adenoma.

Intraductal papillary mucinous neoplasm (IPMN) of the pancreas showed significantly less aggressive pathologic features compared with common pancreatic cancer.

Therefore, several organ-preserving techniques, including duodenum-preserving pancreatic head resection, have been advocated in surgical procedures for IPMN.

We describe a surgical technique of superior head resection of the pancreas with inferior branch preservation followed by a gastric wall-covering method for the prevention of pancreatic leakage in patients with IPMN of the pancreas head.

[MeSH-major] Adenocarcinoma, Mucinous / surgery. Carcinoma, Pancreatic Ductal / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / surgery. Stomach / surgery

[MeSH-minor] Abdominal Pain / diagnosis. Abdominal Pain / etiology. Aged. Anastomosis, Surgical. Cholangiopancreatography, Endoscopic Retrograde / methods. Follow-Up Studies. Humans. Immunohistochemistry. Male. Neoplasm Staging. Risk Assessment. Treatment Outcome

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(PMID = 16720158.001).

[ISSN] 0002-9610

[Journal-full-title] American journal of surgery

[ISO-abbreviation] Am. J. Surg.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

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[Title] Small pancreatic cancer with pancreas divisum preoperatively diagnosed by pancreatic juice cytology.

We present a case of small pancreatic head cancer with pancreas divisum preoperatively diagnosed by pancreatic juice cytology.

A 60-year-old woman was referred to our hospital for evaluation of a dilated main pancreatic duct (MPD).

A small and poorly reproducible low-echoic lesion in the pancreas was suspected by ultrasonography (US) and endoscopic ultrasonography (EUS).

Magnetic resonance cholangiopancreatography (MRCP) failed to visualize the ventral pancreatic duct, and the upstream dorsal pancreatic duct was dilated.

Endoscopic retrograde cholangiopancreatography (ERCP) was indicative of pancreas divisum, and complete obstruction of the MPD in the pancreatic head was seen.

Cytology of pancreatic juice obtained from the dorsal pancreas after minor papilla sphincterotomy revealed the presence of adenocarcinoma cells.

Pancreatoduodenectomy was performed under the diagnosis of pancreatic head cancer with pancreas divisum.

Histological examination revealed moderately-differentiated tubular adenocarcinoma 20 mm in diameter, located in the pancreatic head.

Dilatation of the dorsal pancreatic duct is sometimes observed in cases with pancreas divisum without the presence of tumors.

When pancreatic duct stenosis also exists in such cases, even if a tumor is not clearly visualized by diagnostic imaging, vigorous examinations such as pancreatic juice cytology are recommended to establish an accurate diagnosis.

[MeSH-major] Pancreas / abnormalities. Pancreatic Neoplasms / diagnosis

[MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenocarcinoma / ultrasonography. Cholangiopancreatography, Endoscopic Retrograde. Female. Humans. Middle Aged. Pancreatic Juice / cytology

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(PMID = 19755770.001).

[ISSN] 1349-7235

[Journal-full-title] Internal medicine (Tokyo, Japan)

[ISO-abbreviation] Intern. Med.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Japan

   

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[Title] Advantage of pancreaticogastrostomy in detecting recurrent intraductal papillary mucinous carcinoma in the remnant pancreas: a case of successful re-resection after pancreaticoduodenectomy.

Recently there has been an increase in the number of case reports detailing the recurrence of cancer in the pancreatic remnants following surgical resection of intraductal papillary mucinous carcinoma (IPMC) of the pancreas.

A 68-year-old man underwent PD for IPMC of the pancreatic head, and the cut margin of the pancreatic duct was diagnosed as having no cancer but moderately dysplastic epithelium by an intraoperative frozen section of histology.

Eight years and 6 months later, during a routine follow-up examination, duct dilation of the remnant pancreas was detected by magnetic resonance imaging (MRI).

Upon examination by endoscopic gastroscopy, the anastomotic site was found to be covered with a large amount of mucin from which we easily obtained both cytologic and biopsied specimens, which subsequently proved positive for cancer.

In line with our diagnosis of recurrent IPMC, the patient underwent a second surgery (resection of the remnant pancreas, total pancreatectomy) and postoperative histology confirmed that indeed the patient had experienced recurrent IPMC with no nodal involvement or invasion beyond the pancreatic confines.

Based on this experience, we decided to recommend PG for all patients deemed to be at high risk for the recurrence of cancer in the pancreatic remnants following PD for IPMC of the pancreatic head.

[MeSH-major] Carcinoma, Pancreatic Ductal / surgery. Gastrostomy. Neoplasm Recurrence, Local / surgery. Pancreatic Ducts / surgery. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy

[MeSH-minor] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / surgery. Aged. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / surgery. Follow-Up Studies. Gastroscopy. Humans. Magnetic Resonance Imaging. Male. Pancreatectomy. Reoperation

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[Copyright] Copyright 2006 Wiley-Liss, Inc.

(PMID = 16615155.001).

[ISSN] 0022-4790

[Journal-full-title] Journal of surgical oncology

[ISO-abbreviation] J Surg Oncol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

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[Title] An MRI-driven practice: a new perspective on MRI for the evaluation of adenocarcinoma of the head of the pancreas.

OBJECTIVES: The purpose of the study was to describe the MRI-driven management of masses at the head of the pancreas.

RESULTS: Between 2004 and 2008, we have treated 124 patients for a radiographic diagnosis of adenocarcinoma of the head of the pancreas.

This diagnosis was correct in 96.0% of the time.

CONCLUSION: MRI is a useful tool in the preoperative imaging of pancreatic head lesions that is highly sensitive and very specific for resectable disease.

[MeSH-major] Adenocarcinoma / diagnosis. Magnetic Resonance Imaging / methods. Pancreatic Neoplasms / diagnosis

[MeSH-minor] Aged. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Pancreaticoduodenectomy. Prognosis. Reproducibility of Results. Retrospective Studies. Sensitivity and Specificity. Time Factors

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(PMID = 20467829.001).

[ISSN] 1873-4626

[Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

[ISO-abbreviation] J. Gastrointest. Surg.

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] United States

   

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[Title] Hepatoid carcinoma of the pancreas combined with neuroendocrine carcinoma.

The most common sites of extrahepatic carcinoma are the stomach and ovary, but nine cases of hepatocellular differentiation of the pancreas have been reported in the literature.

We report another case of hepatoid carcinoma of the pancreas that was associated with the development of a pancreatic endocrine carcinoma in a 46-year-old man.

Serum alpha-fetoprotein (AFP) was elevated to 262.49 IU/mL and radiological examinations revealed a mass measuring 7.5 cm in diameter in the head of the pancreas.

He underwent a conventional Whipple operation, and light microscopy showed adenocarcinoma that was immunopositive for AFP, hepatocyte antigen, cytokeratin, chromogranin, synaptophysin, and alpha-1 antichymotrypsin.

Although hepatoid differentiation was not shown unequivocally histologically, other immunohistochemistry findings supported the diagnosis of hepatoid carcinoma combined with neuroendocrine carcinoma.

This report describes why hepatoid carcinoma should be considered as a differential diagnosis of a pancreatic mass, especially when serum AFP is elevated.

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(PMID = 20479919.001).

[ISSN] 2005-1212

[Journal-full-title] Gut and liver

[ISO-abbreviation] Gut Liver

[Language] eng

[Publication-type] Journal Article

[Publication-country] Korea (South)

[Other-IDs] NLM/ PMC2871600

[Keywords] NOTNLM ; Hepatoid carcinoma / Neuroendocrine carcinoma / Pancreas

   

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[Title] Systemic inflammatory response predicts outcome in patients undergoing resection for ductal adenocarcinoma head of pancreas.

The aim of the present study was to examine the relationship between the clinicopathological status, the pre- and postoperative systemic inflammatory response and survival in patients undergoing potentially curative resection for ductal adenocarcinoma of the head of the pancreas.

Patients (n = 65) who underwent resection of ductal adenocarcinoma of the head of pancreas between 1993 and 2001, and had pre- and postoperative measurements of C-reactive protein, were included in the study.

The majority of patients had stage III disease (International Union Against Cancer Criteria, IUCC), positive circumferential margin involvement (R1), tumour size greater than 25 mm with perineural and lymph node invasion and died within the follow-up period.

The results of the present study indicate that, in patients who have undergone potentially curative resection for ductal adenocarcinoma of the head of pancreas, the presence of a systemic inflammatory response predicts poor outcome.

[MeSH-major] Carcinoma, Pancreatic Ductal / immunology. Inflammation / complications. Pancreatic Neoplasms / immunology

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(PMID = 15597096.001).

[ISSN] 0007-0920

[Journal-full-title] British journal of cancer

[ISO-abbreviation] Br. J. Cancer

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Chemical-registry-number] 9007-41-4 / C-Reactive Protein

[Other-IDs] NLM/ PMC2361749

   

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[Title] Cerebellar metastasis from pancreatic adenocarcinoma. A case report.

The first discovery of a cerebellar metastasis of pancreatic carcinoma in a living patient is described.

Two years earlier the patient had undergone a pancreaticoduodenectomy for an adenocarcinoma of the head of the pancreas with a lymph node metastasis.

Clinical evaluation revealed an intracranial tumor without signs of pancreatic recurrence.

[MeSH-major] Adenocarcinoma / secondary. Cerebellar Neoplasms / radiography. Cerebellar Neoplasms / secondary. Pancreatic Neoplasms / pathology

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[Copyright] Copyright (c) 2006 S. Karger AG, Basel and IAP.

(PMID = 16636605.001).

[ISSN] 1424-3903

[Journal-full-title] Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]

[ISO-abbreviation] Pancreatology

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Switzerland

[Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine

   

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[Title] Inferior head resection of the pancreas for intraductal papillary mucinous neoplasms.

Thus, a variety of types of partial pancreatic resections have been advocated for treating these low-grade malignant tumors.

METHODS: We performed a retrospective review of the clinicopathologic features and surgical outcome in 15 patients who underwent inferior head resection for IPMN at the Chiba University Hospital and National Cancer Center Hospital East between July 1994 and January 2007.

Subsequent pancreatoduodenectomy was performed in one patient because of noninvasive carcinoma with multiple mucous lakes in the pancreatic parenchyma.

Pancreatic fistula occurred in 7 (47%) patients.

Two patients died of pancreatic ductal adenocarcinoma, 30 and 78 months after inferior head resection.

CONCLUSIONS: Pancreatic endocrine and exocrine function was well preserved after inferior head resection.

Pancreatic fistula occurred more frequently after inferior head resection than with conventional pancreatoduodenectomy.

[MeSH-major] Adenocarcinoma, Mucinous / surgery. Carcinoma, Pancreatic Ductal / surgery. Carcinoma, Papillary / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / surgery

[MeSH-minor] Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Retrospective Studies. Treatment Outcome

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(PMID = 19727540.001).

[ISSN] 1868-6982

[Journal-full-title] Journal of hepato-biliary-pancreatic sciences

[ISO-abbreviation] J Hepatobiliary Pancreat Sci

[Language] eng

[Publication-type] Comparative Study; Journal Article; Multicenter Study

[Publication-country] Japan

   

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[Title] Clear-cell variant of solid-pseudopapillary neoplasm of the pancreas: a case report and review of the literature.

Solid-pseudopapillary neoplasm (SPN) of the pancreas is a rare neoplasm reported to have a favourable prognosis because of its slow-growing behaviour.

Its clear cell variant creates challenges in distinction from other clear cell tumours in the pancreas.

Exploratory laparotomy revealed a 5.2 cm well-demarcated tumour in the head of the pancreas, which was treated with Whipple procedure.

Difficulties are recognized in differentiating clear-cell SPN from "sugar" tumours, metastatic renal cell carcinoma, clear-cell variant of pancreatic endocrine neoplasm and ductal adenocarcinoma.

When facing such difficulties, nuclear and cytoplamic beta-catenin, nuclear E-cadherin expressions and absence of membranous E-cadherin staining are useful in differentiating clear-cell SPN from other clear cell tumours in the pancreas.

[MeSH-major] Carcinoma, Papillary / pathology. Pancreatic Neoplasms / pathology

[MeSH-minor] Adult. Biomarkers, Tumor / analysis. Carcinoma, Islet Cell / diagnosis. Carcinoma, Pancreatic Ductal / diagnosis. Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / secondary. Cell Nucleus / chemistry. Cell Nucleus / pathology. Cytoplasm / chemistry. Cytoplasm / pathology. Diagnosis, Differential. Female. Humans. Perivascular Epithelioid Cell Neoplasms / diagnosis

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(PMID = 20514858.001).

[ISSN] 0126-8635

[Journal-full-title] The Malaysian journal of pathology

[ISO-abbreviation] Malays J Pathol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Malaysia

[Chemical-registry-number] 0 / Biomarkers, Tumor

   

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[Title] [Intraductal papillary mucinous neoplasms of the pancreas].

INTRODUCTION: Mucin-producing pancreatic tumors account for 1% of all malignant tumors of the pancreas.

Notable among these are intraductal papillary mucinous neoplasms of the pancreas, due to their variable clinical behavior, increased frequency, and the controversy surrounding the most suitable treatment and diagnostic methods.

PATIENTS AND METHOD: We performed a prospective review of patients with a diagnosis of intraductal papillary mucinous neoplasm of the pancreas between 1996 and 2001.

The most frequent localization was the pancreatic head.

Seven patients underwent pancreatic resection and only one patient was not surgically treated.

CONCLUSION: Intraductal papillary mucinous neoplasms of the pancreas generally appear in the sixth decade of life.

These neoplasms typically occur in the head of the pancreas.

[MeSH-major] Adenocarcinoma, Mucinous. Carcinoma, Papillary. Pancreatic Neoplasms

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(PMID = 16420930.001).

[ISSN] 0009-739X

[Journal-full-title] Cirugía española

[ISO-abbreviation] Cir Esp

[Language] spa

[Publication-type] English Abstract; Journal Article

[Publication-country] Spain

   

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Previously, we used the reverse transcription-polymerase chain reaction (RT-PCR) to show that mammaglobin (MGB1) can serve as a differential marker of breast cancer metastasis from primary lung cancer.

Of the other cancers examined, including 29 of the head and neck, eight of the thyroid, 106 of the lung, 35 of the gastrointestinal tract, three of the pancreas, 14 of the uterine cervix and 13 of the ovary, none were positive for MGB1 except a proportion of salivary gland tumors (6/11, 55%) and endometrial cancers (3/23, 13%).

In terms of practical diagnosis, MGB1 immunohistochemistry can serve as a differential marker of breast cancer metastasis from primary lung cancer for two reasons.

Firstly, HER2-positive breast cancer frequently lacks estrogen receptor expression, but MGB1 is expressed in about half of this subtype.

[MeSH-major] Adenocarcinoma / metabolism. Breast Neoplasms / metabolism. Neoplasm Proteins / metabolism. Uteroglobin / metabolism

[MeSH-minor] Biomarkers, Tumor / metabolism. Cell Count. Diagnosis, Differential. Disease-Free Survival. Female. Humans. Immunoenzyme Techniques. Japan / epidemiology. Lung Neoplasms / diagnosis. Lung Neoplasms / metabolism. Lung Neoplasms / secondary. Mammaglobin A. Neoplasm Staging. Receptors, Estrogen / metabolism. Survival Rate. Tissue Array Analysis

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(PMID = 17192791.001).

[ISSN] 0893-3952

[Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

[ISO-abbreviation] Mod. Pathol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mammaglobin A; 0 / Neoplasm Proteins; 0 / Receptors, Estrogen; 0 / SCGB2A2 protein, human; 9060-09-7 / Uteroglobin

   

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[Title] Impact of lymph node involvement on long-term survival after R0 pancreaticoduodenectomy for ductal adenocarcinoma of the pancreas.

Pancreaticoduodenectomy remains the only potentially curative treatment for adenocarcinoma of the pancreas.

The aim of this study was to analyze prognostic factors impacting survival after R0 pancreaticoduodenectomy for adenocarcinoma in the head of the pancreas.

Between 1995 and 2002, a potentially curative (R0) pancreaticoduodenectomy with pancreatogastrostomy for ductal adenocarcinoma in the head of the pancreas was performed in 81 patients (42 women and 39 men) with a mean age of 64 years (range 35-84).

The main risk factor associated with poor survival after an R0 pancreaticoduodenectomy for adenocarcinoma in the head of pancreas was lymph node status: The presence of two or more positive lymph nodes was associated with decreased survival.

[MeSH-major] Adenocarcinoma / surgery. Carcinoma, Pancreatic Ductal / surgery. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy

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[Cites] Am J Surg. 2001 Aug;182(2):120-9 [11574081.001]

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(PMID = 17458610.001).

[ISSN] 1091-255X

[Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

[ISO-abbreviation] J. Gastrointest. Surg.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

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[Title] [A case of metastatic pancreatic cancer after combination chemotherapy with uracil-tegafur and gemcitabine].

We report a case of pancreas head cancer with liver metastasis treated with uracil-tegafur (UFT) and gemcitabine combined chemotherapy.

The histopathological diagnosis was adenocarcinoma, so we inserted a self-expandable metallic stent (EMS) in this inoperable pancreas head cancer.

Renewed liver metastases did not appear, and the pancreas head tumor partially responded.

[MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Deoxycytidine / analogs & derivatives. Pancreatic Neoplasms / drug therapy. Pancreatic Neoplasms / pathology. Tegafur / therapeutic use. Uracil / therapeutic use

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(PMID = 19223756.001).

[ISSN] 0385-0684

[Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy

[ISO-abbreviation] Gan To Kagaku Ryoho

[Language] jpn

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Japan

[Chemical-registry-number] 0W860991D6 / Deoxycytidine; 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; B76N6SBZ8R / gemcitabine

   

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[Title] Long-term survival after pancreatoduodenectomy for pancreatic adenocarcinoma: is cure possible?

OBJECTIVE: To determine long-term survival after pancreatoduodenectomy for pancreatic ductal adenocarcinoma and to identify clinical factors associated with long-term survival.

SUMMARY BACKGROUND DATA: The prognosis for long-term survival even after potentially curative resection for pancreatic adenocarcinoma is thought to be poor.

Clinical factors determining short-term survival after pancreatic resection are well studied, but prognostic factors predicting long-term survival with a potential for cure are poorly understood.

METHODS: A case-control study was conducted of 357 patients who underwent pancreatoduodenectomy for pancreatic ductal adenocarcinoma between 1981 and 2001.

Histologic specimens were reanalyzed to confirm diagnosis.

Five-year survival was no guarantee of cure because 16% of this subset died of pancreatic cancer up to 7.8 years after operation.

CONCLUSION: Pancreatoduodenectomy for adenocarcinoma in the head of pancreas can provide long-term survival in a subset of patients, particularly in the absence of lymph node metastasis.

[MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / surgery. Pancreatic Neoplasms / mortality. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy

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(PMID = 18376190.001).

[ISSN] 0003-4932

[Journal-full-title] Annals of surgery

[ISO-abbreviation] Ann. Surg.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Serum Albumin

   

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[Title] Pancreatic and extrapancreatic lesions in patients with intraductal papillary mucinous neoplasms of the pancreas: a single-centre experience.

RESULTS: Pancreatic IPMN was localised in the head in 43 patients (30.3%), in the body in 13 (9.2%), in the tail in ten (7.0%), in the head-body in 17 (12.0%), in the body-tail in 15 (10.6%) diffuse throughout the gland in 44 (31.0%).

Twenty patients (14.1%) had associated pancreatic or extrapancreatic diseases.

In evaluating the distribution of pancreatic or extrapancreatic diseases according to IPMN type, we found that this was not significantly different among types I, II and III (p=0.776).

CONCLUSIONS: The majority of pancreatic and extrapancreatic cancers occur before the diagnosis of IPMNs is made and is not related to the type of IPMN.

[MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Papillary / pathology. Diagnostic Imaging. Neoplasms, Multiple Primary / pathology. Neoplasms, Second Primary / pathology. Pancreatic Neoplasms / pathology

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[Cites] Abdom Imaging. 2007 May-Jun;32(3):374-80 [16967247.001]

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(PMID = 20082228.001).

[ISSN] 1826-6983

[Journal-full-title] La Radiologia medica

[ISO-abbreviation] Radiol Med

[Language] eng; ita

[Publication-type] Journal Article

[Publication-country] Italy

[Chemical-registry-number] 0 / Contrast Media

   

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[Title] Immuno-histopathological correlations in exocrine pancreatic cancer.

OBJECTIVE: Study of CA19-9 antigen from the immunological point of view, at the patients with pancreatic cancer, and his relation with the histopathological aspects.

MATERIAL AND METHOD: The determinations have been done at the time of the diagnosis and after the treatment of the patients with pancreatic cancer (25).

RESULTS: The values of the CA19-9 marker have been increased at the time of the diagnosis either in pancreatic cancer of the head and mid.

At the moment of the diagnosis the CA19-9 marker has higher values (150-400 U/ml) in cancer of the pancreatic body than in cancer of the head of the pancreas (40-200 U/ml).

Correlating the size of the tumor with the value of the CA19-9 marker in the case of pancreatic cancer we have been shown the highest serum values (300-400 U/ml) at patients whose tumor was 3 cm bigger.

The highest values of the CA 19-9 marker were found in cases of mid pancreas adenocarcinoma.

CONCLUSION: CA19-9 marker values higher than normal cause problems to digestive cancer (especially pancreatic).

The high values of CA 19-9 suggest an adenocarcinoma.

[MeSH-major] CA-19-9 Antigen / analysis. Pancreatic Neoplasms / immunology. Pancreatic Neoplasms / pathology

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(PMID = 16287000.001).

[ISSN] 1220-0522

[Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

[ISO-abbreviation] Rom J Morphol Embryol

[Language] eng

[Publication-type] Journal Article

[Publication-country] Romania

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen

   

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[Title] Mangafodipir-DPDP enhanced MRI visualization of a pancreatic adenocarcinoma previously undetected by extracellular contrast enhanced CT and MRI.

We report a case of adenocarcinoma of the head of the pancreas, occult at extracellular contrast enhanced MDCT and magnetic resonance imaging (MRI), which was detected by MRI only with the use of a tissue-specific contrast agent (Mangafodipir trisodium Mn- DPDP).

The histological examination after duodenopancreatectomy confirmed the diagnosis.

Contrast-enhanced multi-detector computed tomography (MDCT) is currently considered to be the reference method for diagnosing and staging of pancreatic adenocarcinoma.

The technological evolution of magnetic resonance imaging and the development of organ-specific contrast media for liver and pancreas have led to a progressively more extensive use of this method for the investigation of suspected lesions.

[MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / radiography. Contrast Media. Edetic Acid / analogs & derivatives. Magnetic Resonance Imaging / methods. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / radiography. Pyridoxal Phosphate / analogs & derivatives. Tomography, X-Ray Computed

[MeSH-minor] Cholangiopancreatography, Endoscopic Retrograde. Female. Humans. Middle Aged. Pancreas / pathology. Pancreaticoduodenectomy

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(PMID = 18330084.001).

[ISSN] 0392-4203

[Journal-full-title] Acta bio-medica : Atenei Parmensis

[ISO-abbreviation] Acta Biomed

[Language] eng

[Publication-type] Case Reports; Comparative Study; Journal Article

[Publication-country] Italy

[Chemical-registry-number] 0 / Contrast Media; 5V5IOJ8338 / Pyridoxal Phosphate; 9G34HU7RV0 / Edetic Acid; P28BIW0UTB / N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid

   

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[Title] [Intraductal papillary mucinous neoplasm of pancreas: a clinicopathologic and immunohistochemical study of 19 cases].

OBJECTIVE: To study the clinicopathologic features and diagnosis of intraductal papillary mucinous neoplasm (IPMN) of the pancreas.

It affected patients in older age group (mean age = 59) and was located mainly in the head of pancreas (60%).

Histologically, the tumor consisted of papillary proliferations protruding into and expanding the pancreatic ducts.

Invasion into the surrounding pancreatic parenchyma was noted in 12 cases and chronic pancreatitis was present in 16 cases.

The prognosis after surgical resection however is better than that of conventional pancreatic adenocarcinoma.

Early recognition by radiologic examination (including ERCP) and pancreatic cytology would be helpful in early diagnosis.

[MeSH-major] Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Papillary / pathology. Immunohistochemistry / trends. Pancreatic Neoplasms / pathology

[MeSH-minor] Adaptor Proteins, Signal Transducing / analysis. Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / metabolism. Adult. Aged. Cell Cycle Proteins / analysis. Cholangiopancreatography, Endoscopic Retrograde. Female. Humans. Ki-67 Antigen / analysis. Male. Middle Aged. Pancreas / metabolism. Pancreas / pathology. Pancreatectomy. Pancreatic Ducts / metabolism. Pancreatic Ducts / pathology. Prognosis. Receptor, ErbB-2 / analysis. Treatment Outcome

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(PMID = 19094485.001).

[ISSN] 0529-5807

[Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology

[ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi

[Language] chi

[Publication-type] English Abstract; Journal Article

[Publication-country] China

[Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / CDCA5 protein, human; 0 / Cell Cycle Proteins; 0 / Ki-67 Antigen; EC 2.7.10.1 / Receptor, ErbB-2

   

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[Title] [Synchronous double invasive ductal carcinomas of the pancreas with multifocal branch duct intraductal papillary mucinous neoplasms of the pancreas].

A 52-year-old man with a history of distal gastrectomy for gastric cancer was admitted to our hospital because of jaundice.

CT scan revealed double tumors in the pancreatic head and body concomitant with multicystic lesions of the pancreas.

Final histological diagnosis was double invasive ductal carcinomas of the pancreas head and tail with multifocal branch duct intraductal papillary mucinous adenomas of the pancreas.

The present case suggests that entire pancreas might have malignant potential in patients with intraductal papillary mucinous neoplasms.

[MeSH-major] Adenocarcinoma, Mucinous / surgery. Carcinoma, Pancreatic Ductal / surgery. Carcinoma, Papillary / surgery. Neoplasms, Multiple Primary. Pancreatic Neoplasms / surgery

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(PMID = 19122428.001).

[ISSN] 0446-6586

[Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology

[ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi

[Language] jpn

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Japan

   

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[Title] Single-branch resection of the pancreas.

The treatment of intraductal papillary mucinous tumors (IPMT) of the pancreas is still controversial.

In this report we describe a single-branch resection of the pancreas (SBRP), which is a new method for the removal of branch-type IPMT of the head of the pancreas.

A multilobular cystic lesion (50 x 40 mm) in the head of the pancreas was incidentally detected in an asymptomatic 40-year-old man who underwent a routine ultrasound examination.

The tumor was carefully removed along the border of the cyst and the normal parenchyma, with complete preservation of the main pancreatic duct and the common bile duct.

A pancreatic fistula developed during the postoperative period, but was well-controlled by endoscopic naso-pancreatic drainage.

SBRP is a technically feasible procedure and this operation represents a minimally invasive alternative to any other segmental resection of the pancreas.

[MeSH-major] Adenocarcinoma, Mucinous / surgery. Adenocarcinoma, Papillary / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / surgery

[MeSH-minor] Adult. Diagnosis, Differential. Diagnostic Imaging. Humans. Male

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(PMID = 15754104.001).

[ISSN] 0944-1166

[Journal-full-title] Journal of hepato-biliary-pancreatic surgery

[ISO-abbreviation] J Hepatobiliary Pancreat Surg

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Japan

   

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[Title] Randomised Phase I/II trial assessing the safety and efficacy of radiolabelled anti-carcinoembryonic antigen I(131) KAb201 antibodies given intra-arterially or intravenously in patients with unresectable pancreatic adenocarcinoma.

BACKGROUND: Advanced pancreatic cancer has a poor prognosis, and the current standard of care (gemcitabine based chemotherapy) provides a small survival advantage.

This study aimed to evaluate the safety and tolerability of KAb201, an anti-carcinoembryonic antigen monoclonal antibody, labelled with I(131) in pancreatic cancer (ISRCTN 16857581).

METHODS: Patients with histological/cytological proven inoperable adenocarcinoma of the head of pancreas were randomised to receive KAb 201 via either the intra-arterial or intravenous delivery route.

[MeSH-major] Adenocarcinoma / diagnostic imaging. Carcinoembryonic Antigen / administration & dosage. Immunotoxins / administration & dosage. Iodine Radioisotopes / administration & dosage. Pancreatic Neoplasms / radiotherapy. Radioimmunotherapy / methods

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(PMID = 19243606.001).

[ISSN] 1471-2407

[Journal-full-title] BMC cancer

[ISO-abbreviation] BMC Cancer

[Language] eng

[Databank-accession-numbers] ISRCTN/ ISRCTN16857581

[Grant] United Kingdom / Medical Research Council / / G9900432; United Kingdom / Cancer Research UK / /

[Publication-type] Clinical Trial, Phase I; Clinical Trial, Phase II; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Neoplasm; 0 / Carcinoembryonic Antigen; 0 / Immunotoxins; 0 / Iodine Radioisotopes

[Other-IDs] NLM/ PMC2656541

   

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[Title] [Local recurrence after surgical resection of pancreatic cancer effectively treated with combined chemoradiotherapy].

We report a patient for whom systemic chemotherapy using gemcitabine was effective against local recurrence of pancreatic cancer.

A 59-year-old man underwent pancreatoduodenectomy for pancreatic head cancer.

The diagnosis was moderately-differentiated tubular adenocarcinoma(tubular type, pT2, pN0, fM0, fStage II ).

Ten months after surgery, the patient had a CT examination which revealed a mass at the cut-end of the pancreas.

Twenty-one months after chemotherapy, CT examination revealed regrowth at the same location at the cut-end of the pancreas, and so radiotherapy was performed at a total 63 Gy.

[MeSH-major] Adenocarcinoma / therapy. Pancreatic Neoplasms / therapy

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(PMID = 19542722.001).

[ISSN] 0385-0684

[Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy

[ISO-abbreviation] Gan To Kagaku Ryoho

[Language] jpn

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Japan

[Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen; 0W860991D6 / Deoxycytidine; 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; B76N6SBZ8R / gemcitabine; 1-UFT protocol

   

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[Title] Multifocal pancreatic intraepithelial neoplasia (PanIN) lesions of the branch ducts associated with lobular parenchymal atrophy in a Japanese patient diagnosed to have familial pancreatic cancer.

This report presents a case of Japanese familial pancreatic cancer (FPC) with multifocal pancreatic intraepithelial neoplasia (PanIN) lesions of the branch ducts probably associated with lobular parenchymal atrophy.

The risk of pancreatic cancer is significantly increased in those associated with FPC, and this risk increases with increasing numbers of affected first-degree relatives, but there have been four Japanese cases reported.

A 63-year-old Japanese male was referred to the hospital for evaluation and treatment of a pancreatic head tumor.

His family history included pancreatic cancer in two-first-degree relatives and three-second-degree relatives.

The histological findings of the main tumor showed a moderately differentiated tubular adenocarcinoma in the head of the pancreas without metastasis of the resected lymph nodes.

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(PMID = 26192174.001).

[ISSN] 1865-7257

[Journal-full-title] Clinical journal of gastroenterology

[ISO-abbreviation] Clin J Gastroenterol

[Language] eng

[Publication-type] Journal Article

[Publication-country] Japan

[Keywords] NOTNLM ; Familial pancreatic cancer / Lobular parenchymal atrophy / PanIN / Pancreatoduodenectomy

   

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[Title] [Computed tomography of pancreatic tumors].

Computed tomography (CT) and in particular multi-detector row computed tomography (MDCT), also known as multislice CT (MSCT), is ideally suited for detecting pancreatic tumors because of the high spatial resolution.The method of choice is hydro-CT which involves distension of the stomach and duodenum by administration of 1-1.5 l water as a negative contrast medium under medically induced hypotension by administration of buscopan.

The patient is laid on the right side at an angle of 30-45 degrees in order to obtain an artefact-free image of the close anatomical relationship around the pancreas head.

After the correct diagnosis of an adenocarcinoma has been made only 20% of all patients are shown to have a surgically resectable disease, but the overall survival rate is significantly higher after resection in combination with a multimodal tumor therapy strategy.

The reason is that the correct diagnosis of the resectability of the tumor is one of the main criteria for overall survival of these patients.

Currently practically all pancreatic tumors can be detected using MDCT and the detection rate varies between 70% and 100% (most recent literature references give a sensitivity of 89% and specificity up to 99%).

In some rare cases the differentiation between focal necrotizing pancreatitis and pancreatic carcinoma can be difficult even with sophisticated protocols.

MDCT is an ideal tool for the detection of neuroendocrine tumors, metastases and for the differentiation of cystic pancreatic lesions such as pseudocysts, microcystic adenomas or intraductal papillary mucinous neoplasms (IPMN).

Particularly, the differentiation of the latter into benign, borderline or malignant transformation is not always possible, but indirect signs, such as small nodules adjacent to the ductal wall, the diameter of the pancreatic duct, or a direct communication between cystic lesions and duct can be detected because of the high spatial resolution and is comparable to the findings in MRI.

[MeSH-major] Image Processing, Computer-Assisted. Imaging, Three-Dimensional. Pancreatic Neoplasms / diagnostic imaging. Tomography, Spiral Computed

[MeSH-minor] Adenocarcinoma / diagnostic imaging. Adenocarcinoma / mortality. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adenocarcinoma, Mucinous / diagnostic imaging. Adenocarcinoma, Mucinous / mortality. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / surgery. Carcinoma, Pancreatic Ductal / diagnostic imaging. Carcinoma, Pancreatic Ductal / mortality. Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Pancreatic Ductal / surgery. Carcinoma, Papillary / diagnostic imaging. Carcinoma, Papillary / mortality. Carcinoma, Papillary / pathology. Carcinoma, Papillary / surgery. Diagnosis, Differential. Disease-Free Survival. Humans. Neuroendocrine Tumors / diagnostic imaging. Neuroendocrine Tumors / mortality. Neuroendocrine Tumors / pathology. Neuroendocrine Tumors / surgery. Pancreas / diagnostic imaging. Pancreas / pathology. Pancreatectomy. Pancreatic Pseudocyst / diagnostic imaging. Prognosis. Sensitivity and Specificity

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(PMID = 19137277.001).

[ISSN] 1432-2102

[Journal-full-title] Der Radiologe

[ISO-abbreviation] Radiologe

[Language] ger

[Publication-type] Journal Article; Review

[Publication-country] Germany

[Number-of-references] 71

   

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[Title] An unusual case of pancreatic cancer with leptomeningeal infiltration.

INTRODUCTION: Pancreatic cancer is a common malignancy and often presents at an advanced stage.

We aim to describe an unusual case of leptomeningeal involvement from pancreatic cancer.

CT scan of the abdomen showed subtle narrowing of the common bile duct and pancreatic ducts.

Endoscopic ultrasound showed a 5-cm lesion in the head of the pancreas with adenocarcinoma cells on fine needle aspiration.

DISCUSSION: This case represents the unusual presentation of advanced leptomeningeal carcinomatosis in a locally early stage pancreatic adenocarcinoma.

[MeSH-major] Adenocarcinoma / secondary. Meningeal Carcinomatosis / secondary. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / pathology

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(PMID = 20069465.001).

[ISSN] 1941-6636

[Journal-full-title] Journal of gastrointestinal cancer

[ISO-abbreviation] J Gastrointest Cancer

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Antimetabolites, Antineoplastic; 04079A1RDZ / Cytarabine; WI4X0X7BPJ / Hydrocortisone; YL5FZ2Y5U1 / Methotrexate

   

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[Title] Pancreatic adenocarcinoma.

Adenocarcinoma is the most common malignant pancreatic tumor, affecting the head of the pancreas in 60-70% of cases.

By the time of diagnosis, at least 80% of tumors are unresectable.

Helical computed tomography (CT) is very effective in detecting and staging adenocarcinoma, with a sensitivity of up to 90% for detection and an accuracy of 80-90% for staging, but it has limitations in detecting small cancers.

MDCT has been found to be at least equivalent to contrast-enhanced magnetic resonance imaging (MRI) for detecting adenocarcinoma.

Mangafodipir-enhanced MRI reveals a very high tumor-pancreas contrast, which helps in diagnosing small cancers.

It is the technique of choice for image-guided biopsy if a histologic diagnosis is required for further therapy.

[MeSH-major] Adenocarcinoma / diagnosis. Pancreatic Neoplasms / diagnosis. Tomography, X-Ray Computed

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(PMID = 17021700.001).

[ISSN] 0938-7994

[Journal-full-title] European radiology

[ISO-abbreviation] Eur Radiol

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] Germany

[Chemical-registry-number] 0 / Contrast Media

[Number-of-references] 65

   

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[Title] Different approaches to assessment of lymph nodes and surgical margin status in patients with ductal adenocarcinoma of the pancreas treated with pancreaticoduodenectomy.

AIM: To develop a method of gross examination of pancreaticoduodenectomy specimens with pancreatic ductal adenocarcinoma, allowing adequate assessment of the entire pancreatic surface as a surgical margin, which would not affect the lymph node yield.

(1) period 2006-2007, when the pancreatic surface (except for the transection margin and superior mesenteric artery margin) was not examined;.

(2) period January-September 2008, when the posterior pancreatic surface (posterior circumferential radial margin) was examined using an improved method based on sampling of 2.0-2.5 mm thick consecutive slices perpendicular to the duodenal axis; and (3) period October 2008 - June 2009, when the whole surface of the pancreatic head was sampled using the approach mentioned above.

CONCLUSIONS: The newly proposed approach allowed adequate assessment of the entire pancreatic head surface as a surgical margin and reduced the risk of under-detection of R1 status.

[MeSH-major] Carcinoma, Pancreatic Ductal / secondary. Lymph Nodes / pathology. Pancreatic Neoplasms / pathology. Pancreaticoduodenectomy

[MeSH-minor] Aged. Female. Humans. Lymphatic Metastasis / diagnosis. Male. Middle Aged. Neoplasm, Residual. Retrospective Studies

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(PMID = 20085515.001).

[ISSN] 1465-3931

[Journal-full-title] Pathology

[ISO-abbreviation] Pathology

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] England

   

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[Title] Endoscopic diagnosis of squamous cell carcinoma of the pancreas invading the stomach.

CONTEXT: Squamous cell carcinoma of the pancreas is an unusual tumor due to the absence of squamous cells in the normal pancreas.

Its clinical presentation is similar to that of adenocarcinoma of the pancreas and is usually diagnosed intraoperatively or at autopsy.

Contrast-enhanced computerized tomography revealed a heterogeneous enhancing mass in the head of pancreas and upper gastrointestinal endoscopy revealed an ulcerated polypoidal lesion in the stomach; the endoscopic biopsies taken from this region revealed infiltration of the lamina propria with malignant squamous cells.

CONCLUSION: A rare case of squamous cell carcinoma of the head of the pancreas presenting with obstructive jaundice and gastric outlet obstruction and in which diagnosis was established by endoscopic biopsies of the stomach has been described.

[MeSH-major] Carcinoma, Squamous Cell / diagnosis. Pancreatic Neoplasms / diagnosis. Stomach / pathology

[MeSH-minor] Diagnosis, Differential. Endoscopy, Gastrointestinal. Humans. Male. Middle Aged

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(PMID = 19287113.001).

[ISSN] 1590-8577

[Journal-full-title] JOP : Journal of the pancreas

[ISO-abbreviation] JOP

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Italy

   

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[Title] Primary pancreatic lymphoma. Report of five cases.

Primary pancreatic lymphoma (PPL) is a very rare disease.

None of these patients had evidence of extrapancreatic disease and they were categorized as PPL involving pancreas only (stage IE, 3 patients) or pancreas and peripancreatic lymph nodes (stage IIE, 2 patients).

Imaging techniques showed a mass of the pancreatic head in all cases.

The histological diagnosis (3 diffuse-large cell non-Hodgkin's lymphoma and 2 lymphoplasmacytic lymphoma/immunocytoma) was made by ultrasound-guided fine needle aspiration biopsy and tissue core fine-needle biopsy in three patients and by surgery in the remaining two patients.

1) imaging techniques can suggest the suspicion of PPL but are unable to distinguish PPL from pancreatic adenocarcinoma;.

2) histological diagnosis can be easily obtained by percutaneous US-guided tissue core biopsy;.

3) surgery can be avoided both for diagnosis and therapy but the treatment of choice of PPL may only be evaluated on a larger series of patients.

[MeSH-major] Lymphoma, Non-Hodgkin / diagnosis. Lymphoma, Non-Hodgkin / therapy. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / therapy

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(PMID = 15713583.001).

[ISSN] 1592-8721

[Journal-full-title] Haematologica

[ISO-abbreviation] Haematologica

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Italy

   

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[Title] Outcome of pancreaticoduodenectomy with extended retroperitoneal lymphadenectomy for adenocarcinoma of the head of the pancreas.

BACKGROUND: Nowadays, there is a remarkable rise in resectability rate of periampullary adenocarcinoma and the mortality and morbidity of the pancreaticoduodenectomy procedure have been reduced remarkably, while the 5 year survival rates of patients with carcinoma of the head of the pancreas are still below 25%.

We conducted this retrospective study to evaluate the clinical outcome of radical pancreaticoduodenectomy with extended retroperitoneal lymphadenectomy as a surgical therapy for adenocarcinoma of the head of the pancreas.

METHODS: Twenty cases with adenocarcinoma of the head of the pancreas were treated by standard pancreaticoduodenectomy (removing only the peripancreatic lymph nodes en bloc with the tumour) from 1994 to 1997, and 46 cases with the same disease underwent extended retroperitoneal lymphadenectomy associated with standard pancreaticoduodenectomy from 1998 to 2002.

Of the 46 cases in the radical group, 26% (12/46) had metastatic adenocarcinoma in the resected retroperitoneal lymph nodes.

[MeSH-major] Adenocarcinoma / surgery. Lymph Node Excision. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy

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(PMID = 16313840.001).

[ISSN] 0366-6999

[Journal-full-title] Chinese medical journal

[ISO-abbreviation] Chin. Med. J.

[Language] eng

[Publication-type] Journal Article

[Publication-country] China

   

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[Title] [Surgical treatment of pancreatic adenocarcinoma using cephalic duodenopancreatectomy (Part 2). Long term follow up after 204 cases].

[Transliterated title] Tratamiento quirúrgico del adenocarcinoma pancreático mediante duodenopancreatectomía cefálica (parte 2). Seguimiento a largo plazo tras 204 casos.

INTRODUCTION: Surgery is the accepted treatment in adenocarcinoma of the head of the pancreas; however, the long-term survival continues to be low.

The aim of this study is to define prognostic factors of long-term survival after cephalic duodenopancreatectomy due to pancreatic adenocarcinoma.

MATERIAL AND METHODS: We have collected data on the treatment of adenocarcinoma of the head of the pancreas (ADHP) by means of a cephalic duodenopancreatectomy (CDP) performed n the Bellvitge University Hospital (Barcelona) from 1991 to 2007.

CONCLUSIONS: Surgery of head of the pancreas adenocarcinoma must include an adequate lymphadectomy, and must be performed with a low morbidity and without the need of a peri-operative transfusion.

[MeSH-major] Adenocarcinoma / surgery. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy

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[Copyright] Copyright © 2010 AEC. Published by Elsevier Espana. All rights reserved.

[CommentIn] Cir Esp. 2011 Jun-Jul;89(6):411; author reply 412 [21550599.001]

(PMID = 21030012.001).

[ISSN] 1578-147X

[Journal-full-title] Cirugía española

[ISO-abbreviation] Cir Esp

[Language] spa

[Publication-type] English Abstract; Journal Article

[Publication-country] Spain

   

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[Title] Does multidetector-row CT eliminate the role of diagnostic laparoscopy in assessing the resectability of pancreatic head adenocarcinoma?

BACKGROUND: We hypothesized that the high-quality images from multidetector-row computed tomography (MDCT) would lead to improved sensitivity and specificity for predicting resectable pancreatic head adenocarcinoma, thus diminishing the value of staging laparoscopy.

CONCLUSIONS: Despite the improvements in image quality obtained with multidetector-row technology, CT imaging remains a relatively nonspecific test for predicting resectability in patients with adenocarcinoma of the head of the pancreas.

Minimally invasive modalities with higher specificity, particularly laparoscopy, continue to have an important role in staging pancreatic head adenocarcinoma.

[MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Laparoscopy. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / surgery. Tomography, X-Ray Computed

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(PMID = 15624058.001).

[ISSN] 1432-2218

[Journal-full-title] Surgical endoscopy

[ISO-abbreviation] Surg Endosc

[Language] eng

[Publication-type] Journal Article

[Publication-country] Germany

   

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[Title] [Local recurrence of pancreatic cancer successfully treated with gemcitabine].

We report a patient for whom systemic chemotherapy using gemcitabine was effective against local recurrence of pancreatic cancer.

A 58-year-old man underwent pancreatoduodenectomy for a pancreatic head cancer.

The diagnosis was Stage IVb poorly-differentiated tubular adenocarcinoma, scirrhous type, pT4, PL (+), P0, H0, pN2.

Gastroscopy and CT examination revealed a mass at the cut-end of the pancreas invading the stomach.

The recurrent tumor in the stomach disappeared, and the mass at the cut-end of the pancreas became small.

Two years after the diagnosis of recurrence, he returned to work, and his chemotherapy is being continued as an outpatient.

[MeSH-major] Adenocarcinoma / drug therapy. Antimetabolites, Antineoplastic / therapeutic use. Deoxycytidine / analogs & derivatives. Deoxycytidine / therapeutic use. Neoplasm Recurrence, Local / drug therapy. Pancreatic Neoplasms / drug therapy. Stomach Neoplasms / drug therapy

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(PMID = 15751641.001).

[ISSN] 0385-0684

[Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy

[ISO-abbreviation] Gan To Kagaku Ryoho

[Language] jpn

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Japan

[Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine

   

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[Title] Pancreatic tail cancer with sole manifestation of left flank pain: a very rare presentation.

Pancreatic cancer is sometimes called a "silent disease" because it often causes no symptoms in the early stage.

The symptoms can be quite vague and various depending on the location of cancer in the pancreas.

The anatomic site distribution is 78% in the head of the pancreas, 11% in the body, and 11% in the tail.

Pancreatic cancer is rarely detected in the early stage, and it is very uncommon to diagnose pancreatic tail cancer during an emergency department visit.

The manifestation of pancreatic tail cancer as left flank pain is very rare and has seldom been identified in the literature.

We present a case of pancreatic tail cancer with the sole manifestation of dull left flank pain.

Radiographic evaluation with computed tomography was performed, and pancreatic tail tumor with multiple metastases was found unexpectedly.

We review the literature and discuss this rare presentation of pancreatic tail cancer.

[MeSH-major] Flank Pain / diagnosis. Pancreatic Neoplasms / diagnosis

[MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Fatal Outcome. Female. Humans. Liver Neoplasms / pathology. Liver Neoplasms / secondary. Medical Oncology / methods. Middle Aged. Neoplasm Metastasis. Prognosis. Tomography, X-Ray Computed

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(PMID = 18635419.001).

[ISSN] 1607-551X

[Journal-full-title] The Kaohsiung journal of medical sciences

[ISO-abbreviation] Kaohsiung J. Med. Sci.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] China (Republic : 1949- )

   

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[Title] Primary pancreatic lymphomas.

Primary pancreatic lymphomas are extremely rare.

Clinically, primary pancreatic lymphomas usually present with symptoms of carcinoma of the pancreatic head.

Patients with primary pancreatic lymphomas are between 35 and 75 years of age and with a strong male predominance.

An accurate cytopathologic diagnosis by fine-needle aspiration (FNA) is imperative because the primary treatment is non-surgical.

FNA coupled with flow cytometry analysis appears to be highly accurate in the diagnosis of primary pancreatic lymphomas.

Fluorescence in-situ hybridisation technique has been established its role in the diagnosis of lymphoid malignancies, including primary pancreatic lymphomas.

The differential diagnoses of primary pancreatic lymphomas include secondary lymphoma, pancreatic endocrine neoplasm, and florid chronic pancreatitis.

Primary pancreatic lymphomas has a much better prognosis than adenocarcinoma of the pancreas.

[MeSH-major] Lymphoma / diagnosis. Pancreatic Neoplasms / diagnosis

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(PMID = 16685107.001).

[ISSN] 1590-8577

[Journal-full-title] JOP : Journal of the pancreas

[ISO-abbreviation] JOP

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] Italy

[Number-of-references] 40

   

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[Title] Castleman's disease in the head of the pancreas: report of a rare clinical entity and current perspective on diagnosis, treatment, and outcome.

BACKGROUND: Castleman's disease of the pancreas is a very rare condition that may resemble more common disease entities as well as pancreatic cancer.

CASE PRESENTATION: Here we report the case of a 58-year-old African American male with an incidentally discovered lesion in the head of the pancreas.

CONCLUSION: To date, eight cases of Castleman's disease associated with the pancreas have been described in the world literature.

We report the first case of unicentric disease situated within the head of the pancreas.

In addition, we discuss the diagnostic dilemma Castleman's disease may present to the pancreatic surgeon and review current data on pathogenesis, treatment, and outcome.

[MeSH-major] Giant Lymph Node Hyperplasia / pathology. Pancreatic Diseases / pathology

[MeSH-minor] Adenocarcinoma / pathology. Diagnosis, Differential. Humans. Male. Middle Aged. Pancreatic Neoplasms / pathology. Pancreaticoduodenectomy. Tomography, X-Ray Computed

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(PMID = 18028547.001).

[ISSN] 1477-7819

[Journal-full-title] World journal of surgical oncology

[ISO-abbreviation] World J Surg Oncol

[Language] eng

[Publication-type] Case Reports; Journal Article; Review

[Publication-country] England

[Number-of-references] 47

[Other-IDs] NLM/ PMC2206042

   

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Most commonly reported malignancies include cholangiocarcinoma, adenocarcinoma, and gallbladder cancer.

Endoscopic retrograde cholangiopancreatography and direct cholangioscopy revealed a mass at the biliary bifurcation, a 4-cm choledochal cyst with multiple calculi, absence of anomalous pancreaticobiliary ductal union, and multiple calcifications in the pancreatic head.

We report the associated rare finding of chronic calcific pancreatitis, without anomaly of the pancreatic biliary junction.

[MeSH-minor] Adult. Biopsy. Cholangiopancreatography, Endoscopic Retrograde. Female. Humans. Pancreatitis, Chronic / diagnosis. Pancreatitis, Chronic / etiology

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(PMID = 18274902.001).

[ISSN] 0163-2116

[Journal-full-title] Digestive diseases and sciences

[ISO-abbreviation] Dig. Dis. Sci.

[Language] eng

[Publication-type] Case Reports; Journal Article; Review

[Publication-country] United States

[Number-of-references] 19

   

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A 57 years old male patient is presented with a mucinous carcinoma of the caecum and an adenocarcinoma of the pancreas head.

His family history was significant for two cases of colon carcinoma, two cases of stomach cancer and a case of metacron endometrial and skin tumor as well.

[MeSH-minor] Adenocarcinoma, Mucinous / genetics. Adenocarcinoma, Mucinous / pathology. Cecal Neoplasms / genetics. Cecal Neoplasms / pathology. Family Health. Humans. Male. Middle Aged. Pancreatic Neoplasms / genetics. Pancreatic Neoplasms / pathology. Pedigree

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(PMID = 19423266.001).

[ISSN] 1532-2157

[Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

[ISO-abbreviation] Eur J Surg Oncol

[Language] eng

[Publication-type] Case Reports; Journal Article; Review

[Publication-country] England

[Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / MLH1 protein, human; 0 / MLH2 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins

[Number-of-references] 15

   

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[Title] Solid type clear cell carcinoma of the pancreas: differential diagnosis of an unusual case and review of the literature.

Pancreatic neoplasms have been reliably classified on the basis of their histopathology and immunophenotype.

In this study, we report on a pancreatic tumor whose phenotype and genotype could not be assigned to any known tumor entity.

The tumor was observed in the pancreatic head of a 54-year-old woman.

DNA microarray analysis revealed a transcription profile clearly differing from that of normal pancreatic tissue and pancreatic ductal adenocarcinoma.

Despite metastatic behavior, the tumor displayed a more favorable course than conventional pancreatic ductal adenocarcinoma.

We suggest that this tumor be called solid type clear cell carcinoma of the pancreas.

[MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Pancreatic Neoplasms / diagnosis

[MeSH-minor] Diagnosis, Differential. Female. Gene Expression Profiling. Humans. Immunohistochemistry. Keratins / metabolism. Liver Neoplasms / diagnostic imaging. Liver Neoplasms / secondary. Microarray Analysis. Middle Aged. Mucin-1 / metabolism. Oligonucleotide Array Sequence Analysis. Reverse Transcriptase Polymerase Chain Reaction. S100 Proteins / metabolism. Tomography, Spiral Computed. Vimentin / metabolism

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NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

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(PMID = 17453235.001).

[ISSN] 0945-6317

[Journal-full-title] Virchows Archiv : an international journal of pathology

[ISO-abbreviation] Virchows Arch.

[Language] eng

[Publication-type] Case Reports; Journal Article; Review

[Publication-country] Germany

[Chemical-registry-number] 0 / MUC1 protein, human; 0 / Mucin-1; 0 / S100 Proteins; 0 / Vimentin; 68238-35-7 / Keratins

[Number-of-references] 39

   

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[Title] Adenocarcinoma involving the whole pancreas with multiple pancreatic masses.

A 77-year-old man was referred to our hospital for further investigation of pancreatic masses.

Imaging studies revealed hypovascular masses in the pancreatic head and body.

Total pancreatectomy was performed under the diagnosis of double primary pancreatic carcinomas.

Macroscopic examination revealed 3 nodules: one each in the pancreatic head, body, and tail.

Incidentally, we also identified an adenocarcinoma of the common bile duct (CBD).

The final diagnosis was synchronous double cancer involving the whole pancreas and the CBD.

[MeSH-major] Adenocarcinoma / diagnosis. Common Bile Duct Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Pancreatic Neoplasms / diagnosis

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(PMID = 20686284.001).

[ISSN] 1349-7235

[Journal-full-title] Internal medicine (Tokyo, Japan)

[ISO-abbreviation] Intern. Med.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Japan

   

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[Title] Adenocarcinoma of the pancreas undetected by multidetector CT, endoscopic ultrasound, or intraoperative ultrasound.

CONTEXT: Patients with known or suspected pancreatic adenocarcinoma are typically evaluated with noninvasive imaging studies and endoscopic ultrasound.

Some patients have pancreatic adenocarcinomas that cannot be detected using any of these methods.

Multiple endoscopic ultrasound and triple phase pancreatic protocol CT exams were negative for a mass lesion and revealed a normal pancreas.

Intraoperative ultrasound of the pancreas was also felt to be normal.

Intraoperative biopsy of the head of the pancreas revealed a small, moderately to poorly differentiated adenocarcinoma, not visible on any of her imaging studies.

CONCLUSION: Some pancreatic adenocarcinomas may defy detection using modern imaging modalities.

[MeSH-major] Adenocarcinoma / diagnosis. Diagnostic Errors. Pancreatic Neoplasms / diagnosis

[MeSH-minor] Cholangiopancreatography, Endoscopic Retrograde / methods. Delayed Diagnosis. Endosonography / methods. Female. Humans. Intraoperative Period. Middle Aged. Tomography, X-Ray Computed / methods. Ultrasonography, Interventional

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(PMID = 19734637.001).

[ISSN] 1590-8577

[Journal-full-title] JOP : Journal of the pancreas

[ISO-abbreviation] JOP

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Italy

   

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The patients with autoimmune pancreatitis usually present with jaundice and a pancreatic head mass, presumed to have pancreatic cancer, and they often undergo pancreatic resection.

Elevated serum IgG4 levels (>135 mg/dL) help to distinguish autoimmune pancreatitis from pancreatic cancer.

However, when the biopsy from a pancreatic mass shows dense chronic inflammation and fibrosis and the serum IgG4 level is not available, it presents a diagnostic dilemma whether it represents autoimmune pancreatitis or peritumoral pancreatitis.

We performed IgG4 immunohistochemistry on 25 cases of autoimmune pancreatitis-lymphoplasmacytic sclerosing pancreatitis, 7 cases of autoimmune pancreatitis with granulocytic epithelial lesions, 8 cases of nonspecific pancreatitis, 15 cases of pancreatitis associated with pancreatic ductal adenocarcinoma, and 5 biopsies of pancreatic adenocarcinoma with variable inflammation.

[MeSH-major] Autoimmune Diseases / diagnosis. Carcinoma, Pancreatic Ductal / diagnosis. Immunoglobulin G / immunology. Pancreas / immunology. Pancreatic Neoplasms / diagnosis. Pancreatitis / diagnosis

[MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD / immunology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged. Plasma Cells / immunology

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[Copyright] Copyright 2010 Elsevier Inc. All rights reserved.

(PMID = 20149413.001).

[ISSN] 1532-8392

[Journal-full-title] Human pathology

[ISO-abbreviation] Hum. Pathol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Antigens, CD; 0 / Immunoglobulin G