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[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Systemic inflammatory response predicts outcome in patients undergoing resection for ductal adenocarcinoma head of pancreas.

The aim of the present study was to examine the relationship between the clinicopathological status, the pre- and postoperative systemic inflammatory response and survival in patients undergoing potentially curative resection for ductal adenocarcinoma of the head of the pancreas.

Patients (n = 65) who underwent resection of ductal adenocarcinoma of the head of pancreas between 1993 and 2001, and had pre- and postoperative measurements of C-reactive protein, were included in the study.

The majority of patients had stage III disease (International Union Against Cancer Criteria, IUCC), positive circumferential margin involvement (R1), tumour size greater than 25 mm with perineural and lymph node invasion and died within the follow-up period.

The results of the present study indicate that, in patients who have undergone potentially curative resection for ductal adenocarcinoma of the head of pancreas, the presence of a systemic inflammatory response predicts poor outcome.

[MeSH-major] Carcinoma, Pancreatic Ductal / immunology. Inflammation / complications. Pancreatic Neoplasms / immunology

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[Cites] Nutr Cancer. 2000;37(1):36-40 [10965517.001]

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(PMID = 15597096.001).

[ISSN] 0007-0920

[Journal-full-title] British journal of cancer

[ISO-abbreviation] Br. J. Cancer

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Chemical-registry-number] 9007-41-4 / C-Reactive Protein

[Other-IDs] NLM/ PMC2361749

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Adenocarcinoma involving the whole pancreas with multiple pancreatic masses.

A 77-year-old man was referred to our hospital for further investigation of pancreatic masses.

Imaging studies revealed hypovascular masses in the pancreatic head and body.

Total pancreatectomy was performed under the diagnosis of double primary pancreatic carcinomas.

Macroscopic examination revealed 3 nodules: one each in the pancreatic head, body, and tail.

Incidentally, we also identified an adenocarcinoma of the common bile duct (CBD).

The final diagnosis was synchronous double cancer involving the whole pancreas and the CBD.

[MeSH-major] Adenocarcinoma / diagnosis. Common Bile Duct Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Pancreatic Neoplasms / diagnosis

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(PMID = 20686284.001).

[ISSN] 1349-7235

[Journal-full-title] Internal medicine (Tokyo, Japan)

[ISO-abbreviation] Intern. Med.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Japan

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Adenocarcinoma of the pancreas undetected by multidetector CT, endoscopic ultrasound, or intraoperative ultrasound.

CONTEXT: Patients with known or suspected pancreatic adenocarcinoma are typically evaluated with noninvasive imaging studies and endoscopic ultrasound.

Some patients have pancreatic adenocarcinomas that cannot be detected using any of these methods.

Multiple endoscopic ultrasound and triple phase pancreatic protocol CT exams were negative for a mass lesion and revealed a normal pancreas.

Intraoperative ultrasound of the pancreas was also felt to be normal.

Intraoperative biopsy of the head of the pancreas revealed a small, moderately to poorly differentiated adenocarcinoma, not visible on any of her imaging studies.

CONCLUSION: Some pancreatic adenocarcinomas may defy detection using modern imaging modalities.

[MeSH-major] Adenocarcinoma / diagnosis. Diagnostic Errors. Pancreatic Neoplasms / diagnosis

[MeSH-minor] Cholangiopancreatography, Endoscopic Retrograde / methods. Delayed Diagnosis. Endosonography / methods. Female. Humans. Intraoperative Period. Middle Aged. Tomography, X-Ray Computed / methods. Ultrasonography, Interventional

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(PMID = 19734637.001).

[ISSN] 1590-8577

[Journal-full-title] JOP : Journal of the pancreas

[ISO-abbreviation] JOP

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Italy

   

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[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Clinical comparison on the classical versus extensive Whipple's resection for adenocarcinoma of head of pancreas].

OBJECTIVE: To evaluate the effect of extensive Whipple's resection to the adenocarcinoma of head of pancreas on the survival, complications, and surgical mortality.

CONCLUSIONS: Postoperative complications and mortality will not increase in extensive Whipple's resection for adenocarcinoma of head of pancreas.

[MeSH-major] Adenocarcinoma / surgery. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / methods

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(PMID = 16274035.001).

[ISSN] 1000-503X

[Journal-full-title] Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

[ISO-abbreviation] Zhongguo Yi Xue Ke Xue Yuan Xue Bao

[Language] chi

[Publication-type] Clinical Trial; Comparative Study; English Abstract; Journal Article

[Publication-country] China

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Ductal adenocarcinoma of the head of the pancreas: a critical study of R1 resection rates].

Complete resection (R0) remains the only potentially curative treatment of ductal adenocarcinoma of the pancreas.

[MeSH-major] Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Pancreatic Ductal / surgery. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / surgery

[MeSH-minor] Humans. Neoadjuvant Therapy. Neoplasm Recurrence, Local. Neoplasm, Residual. Pancreas / pathology. Pancreas / surgery. Pancreatectomy. Prognosis

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(PMID = 19091653.001).

[ISSN] 1769-6917

[Journal-full-title] Bulletin du cancer

[ISO-abbreviation] Bull Cancer

[Language] fre

[Publication-type] English Abstract; Journal Article; Review

[Publication-country] France

[Number-of-references] 29

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Intraductal papillary mucinous neoplasms of the pancreas].

INTRODUCTION: Mucin-producing pancreatic tumors account for 1% of all malignant tumors of the pancreas.

Notable among these are intraductal papillary mucinous neoplasms of the pancreas, due to their variable clinical behavior, increased frequency, and the controversy surrounding the most suitable treatment and diagnostic methods.

PATIENTS AND METHOD: We performed a prospective review of patients with a diagnosis of intraductal papillary mucinous neoplasm of the pancreas between 1996 and 2001.

The most frequent localization was the pancreatic head.

Seven patients underwent pancreatic resection and only one patient was not surgically treated.

CONCLUSION: Intraductal papillary mucinous neoplasms of the pancreas generally appear in the sixth decade of life.

These neoplasms typically occur in the head of the pancreas.

[MeSH-major] Adenocarcinoma, Mucinous. Carcinoma, Papillary. Pancreatic Neoplasms

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(PMID = 16420930.001).

[ISSN] 0009-739X

[Journal-full-title] Cirugía española

[ISO-abbreviation] Cir Esp

[Language] spa

[Publication-type] English Abstract; Journal Article

[Publication-country] Spain

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Castleman's disease in the head of the pancreas: report of a rare clinical entity and current perspective on diagnosis, treatment, and outcome.

BACKGROUND: Castleman's disease of the pancreas is a very rare condition that may resemble more common disease entities as well as pancreatic cancer.

CASE PRESENTATION: Here we report the case of a 58-year-old African American male with an incidentally discovered lesion in the head of the pancreas.

CONCLUSION: To date, eight cases of Castleman's disease associated with the pancreas have been described in the world literature.

We report the first case of unicentric disease situated within the head of the pancreas.

In addition, we discuss the diagnostic dilemma Castleman's disease may present to the pancreatic surgeon and review current data on pathogenesis, treatment, and outcome.

[MeSH-major] Giant Lymph Node Hyperplasia / pathology. Pancreatic Diseases / pathology

[MeSH-minor] Adenocarcinoma / pathology. Diagnosis, Differential. Humans. Male. Middle Aged. Pancreatic Neoplasms / pathology. Pancreaticoduodenectomy. Tomography, X-Ray Computed

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(PMID = 18028547.001).

[ISSN] 1477-7819

[Journal-full-title] World journal of surgical oncology

[ISO-abbreviation] World J Surg Oncol

[Language] eng

[Publication-type] Case Reports; Journal Article; Review

[Publication-country] England

[Number-of-references] 47

[Other-IDs] NLM/ PMC2206042

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] An MRI-driven practice: a new perspective on MRI for the evaluation of adenocarcinoma of the head of the pancreas.

OBJECTIVES: The purpose of the study was to describe the MRI-driven management of masses at the head of the pancreas.

RESULTS: Between 2004 and 2008, we have treated 124 patients for a radiographic diagnosis of adenocarcinoma of the head of the pancreas.

This diagnosis was correct in 96.0% of the time.

CONCLUSION: MRI is a useful tool in the preoperative imaging of pancreatic head lesions that is highly sensitive and very specific for resectable disease.

[MeSH-major] Adenocarcinoma / diagnosis. Magnetic Resonance Imaging / methods. Pancreatic Neoplasms / diagnosis

[MeSH-minor] Aged. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Pancreaticoduodenectomy. Prognosis. Reproducibility of Results. Retrospective Studies. Sensitivity and Specificity. Time Factors

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(PMID = 20467829.001).

[ISSN] 1873-4626

[Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

[ISO-abbreviation] J. Gastrointest. Surg.

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Outcome of pancreaticoduodenectomy with extended retroperitoneal lymphadenectomy for adenocarcinoma of the head of the pancreas.

BACKGROUND: Nowadays, there is a remarkable rise in resectability rate of periampullary adenocarcinoma and the mortality and morbidity of the pancreaticoduodenectomy procedure have been reduced remarkably, while the 5 year survival rates of patients with carcinoma of the head of the pancreas are still below 25%.

We conducted this retrospective study to evaluate the clinical outcome of radical pancreaticoduodenectomy with extended retroperitoneal lymphadenectomy as a surgical therapy for adenocarcinoma of the head of the pancreas.

METHODS: Twenty cases with adenocarcinoma of the head of the pancreas were treated by standard pancreaticoduodenectomy (removing only the peripancreatic lymph nodes en bloc with the tumour) from 1994 to 1997, and 46 cases with the same disease underwent extended retroperitoneal lymphadenectomy associated with standard pancreaticoduodenectomy from 1998 to 2002.

Of the 46 cases in the radical group, 26% (12/46) had metastatic adenocarcinoma in the resected retroperitoneal lymph nodes.

[MeSH-major] Adenocarcinoma / surgery. Lymph Node Excision. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy

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(PMID = 16313840.001).

[ISSN] 0366-6999

[Journal-full-title] Chinese medical journal

[ISO-abbreviation] Chin. Med. J.

[Language] eng

[Publication-type] Journal Article

[Publication-country] China

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Nodal involvement is strongest predictor of poor survival in patients with invasive adenocarcinoma of the head of the pancreas.

BACKGROUND/AIMS: Pancreatic cancer is a devastating disease with an extremely poor prognosis.

The outcome of pancreatic head cancer after surgical resection is still difficult to predict.

METHODOLOGY: Between September 1992 and December 2003, 100 consecutive patients with invasive adenocarcinoma of the head of the pancreas who underwent surgical resection were retrospectively analyzed to clarify the influence of clinicopathological factors.

RESULTS: The overall 1-, 3-, and 5-year survival rates for the 100 patients with pancreatic head cancer were 55%, 16%, and 6%, respectively.

Among the 16 clinicopathologic factors, 9 were significantly associated with outcome in univariate analysis: tumor type (invasive ductal cancer), poor histological differentiation, extrapancreatic plexus invasion, bile duct invasion, duodenal invasion, intrapancreatic nerve invasion, lymphatic invasion, venous invasion, and nodal involvement.

CONCLUSIONS: Nodal involvement was the strongest predictor of poor survival after pancreatic resection for invasive adenocarcinoma of the head of the pancreas.

[MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / pathology. Lymph Nodes / pathology. Pancreatic Neoplasms / mortality. Pancreatic Neoplasms / pathology

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(PMID = 16795990.001).

[ISSN] 0172-6390

[Journal-full-title] Hepato-gastroenterology

[ISO-abbreviation] Hepatogastroenterology

[Language] eng

[Publication-type] Journal Article

[Publication-country] Greece

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] The role of extended lymphadenectomy for adenocarcinoma of the head of the pancreas: strength of the evidence.

Standard pancreaticoduodenectomy continues to be the operation of choice for adenocarcinoma of the head of the pancreas.

[MeSH-major] Adenocarcinoma / surgery. Lymph Node Excision / methods. Pancreatic Neoplasms / surgery

MedlinePlus Health Information. consumer health - Pancreatic Cancer.

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(PMID = 18085343.001).

[ISSN] 1091-255X

[Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

[ISO-abbreviation] J. Gastrointest. Surg.

[Language] eng

[Publication-type] Comparative Study; Journal Article; Review

[Publication-country] United States

[Number-of-references] 22

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Outcome of extended retroperitoneal lymphadenectomy in the surgical treatment of adenocarcinoma of the head of the pancreas].

OBJECTIVE: To evaluate the clinical outcome of extended retroperitoneal lymphadenectomy as surgical therapy for adenocarcinoma of the head of the pancreas.

METHODS: Twenty patients with adenocarcinoma of the head of the pancreas were treated by standard pancreatoduodenectomy (standard group) between 1994 and 1997, and 46 patients with the same disease underwent extended retroperitoneal lymphadenectomy associated with standard pancreatoduodenectomy (radical group) between 1998 and 2002.

Of the 46 patients in the radical group, 26.09% (12/46) had metastatic adenocarcinoma in the resected retroperitoneal lymph nodes.

[MeSH-major] Adenocarcinoma / surgery. Lymph Node Excision / methods. Pancreatic Neoplasms / surgery

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(PMID = 16274033.001).

[ISSN] 1000-503X

[Journal-full-title] Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

[ISO-abbreviation] Zhongguo Yi Xue Ke Xue Yuan Xue Bao

[Language] chi

[Publication-type] English Abstract; Journal Article

[Publication-country] China

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Does multidetector-row CT eliminate the role of diagnostic laparoscopy in assessing the resectability of pancreatic head adenocarcinoma?

BACKGROUND: We hypothesized that the high-quality images from multidetector-row computed tomography (MDCT) would lead to improved sensitivity and specificity for predicting resectable pancreatic head adenocarcinoma, thus diminishing the value of staging laparoscopy.

CONCLUSIONS: Despite the improvements in image quality obtained with multidetector-row technology, CT imaging remains a relatively nonspecific test for predicting resectability in patients with adenocarcinoma of the head of the pancreas.

Minimally invasive modalities with higher specificity, particularly laparoscopy, continue to have an important role in staging pancreatic head adenocarcinoma.

[MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Laparoscopy. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / surgery. Tomography, X-Ray Computed

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(PMID = 15624058.001).

[ISSN] 1432-2218

[Journal-full-title] Surgical endoscopy

[ISO-abbreviation] Surg Endosc

[Language] eng

[Publication-type] Journal Article

[Publication-country] Germany

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Standard with extended pancreaticoduodenectomy for adenocarcinoma of the head of the pancreas: a meta-analysis].

OBJECTIVE: To compare standard with extended pancreaticoduodenectomy for adenocarcinoma of the head of the pancreas: a meta-analysis of randomized controlled trials and prospective studies.

METHODS: Randomized controlled trials and prospective studies comparing standard with extended pancreaticoduodenectomy for pancreatic cancer of head were identified using a systematic search of Medline, the Cochrane Library Databases and CBMDisc covering articles published from 1996 to 2005.

Whipple procedure is also of choice for pancreatic head carcinoma and extended pancreaticoduodenectomy is indicated for lymph node positive patient (A-level).

[MeSH-major] Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / methods

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(PMID = 17403281.001).

[ISSN] 0529-5815

[Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]

[ISO-abbreviation] Zhonghua Wai Ke Za Zhi

[Language] chi

[Publication-type] English Abstract; Journal Article; Meta-Analysis

[Publication-country] China

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Pancreatic adenocarcinoma in young patient diagnosed by endoscopic ultrasonography].

[Transliterated title] Adenocarcinoma de páncreas en paciente joven diagnosticado por ultrasonografía endoscópica.

The Pancreatic adenocarcinoma appears generally in patients with more than 60 years old.

The tomografic image showed a mass located in the head of the pancreas with hepatic and ganglionar metastases.

It was evaluated by means of endoscopic ultrasonography (USE) and performed a directed fine needle puncture aspiration (PAAF), that obtained a bad differentiated adenocarcinoma from the pancreas.

We present the case by the unusual occurrence in the related age group and by the importance of the puncture guided by endoscopic ultrasonography in the diagnosis and handling of this pathology [corrected]

[MeSH-major] Adenocarcinoma / ultrasonography. Endosonography. Pancreatic Neoplasms / ultrasonography

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[ErratumIn] Rev Gastroenterol Peru. 2008 Jul-Sep;28(3):293

(PMID = 18641779.001).

[ISSN] 1022-5129

[Journal-full-title] Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú

[ISO-abbreviation] Rev Gastroenterol Peru

[Language] spa

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Peru

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Mangafodipir-DPDP enhanced MRI visualization of a pancreatic adenocarcinoma previously undetected by extracellular contrast enhanced CT and MRI.

We report a case of adenocarcinoma of the head of the pancreas, occult at extracellular contrast enhanced MDCT and magnetic resonance imaging (MRI), which was detected by MRI only with the use of a tissue-specific contrast agent (Mangafodipir trisodium Mn- DPDP).

The histological examination after duodenopancreatectomy confirmed the diagnosis.

Contrast-enhanced multi-detector computed tomography (MDCT) is currently considered to be the reference method for diagnosing and staging of pancreatic adenocarcinoma.

The technological evolution of magnetic resonance imaging and the development of organ-specific contrast media for liver and pancreas have led to a progressively more extensive use of this method for the investigation of suspected lesions.

[MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / radiography. Contrast Media. Edetic Acid / analogs & derivatives. Magnetic Resonance Imaging / methods. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / radiography. Pyridoxal Phosphate / analogs & derivatives. Tomography, X-Ray Computed

[MeSH-minor] Cholangiopancreatography, Endoscopic Retrograde. Female. Humans. Middle Aged. Pancreas / pathology. Pancreaticoduodenectomy

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Hazardous Substances Data Bank. Disodium EDTA .

Hazardous Substances Data Bank. ETHYLENEDIAMINE TETRAACETIC ACID .

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(PMID = 18330084.001).

[ISSN] 0392-4203

[Journal-full-title] Acta bio-medica : Atenei Parmensis

[ISO-abbreviation] Acta Biomed

[Language] eng

[Publication-type] Case Reports; Comparative Study; Journal Article

[Publication-country] Italy

[Chemical-registry-number] 0 / Contrast Media; 5V5IOJ8338 / Pyridoxal Phosphate; 9G34HU7RV0 / Edetic Acid; P28BIW0UTB / N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Long-term survival after pancreatoduodenectomy for pancreatic adenocarcinoma: is cure possible?

OBJECTIVE: To determine long-term survival after pancreatoduodenectomy for pancreatic ductal adenocarcinoma and to identify clinical factors associated with long-term survival.

SUMMARY BACKGROUND DATA: The prognosis for long-term survival even after potentially curative resection for pancreatic adenocarcinoma is thought to be poor.

Clinical factors determining short-term survival after pancreatic resection are well studied, but prognostic factors predicting long-term survival with a potential for cure are poorly understood.

METHODS: A case-control study was conducted of 357 patients who underwent pancreatoduodenectomy for pancreatic ductal adenocarcinoma between 1981 and 2001.

Histologic specimens were reanalyzed to confirm diagnosis.

Five-year survival was no guarantee of cure because 16% of this subset died of pancreatic cancer up to 7.8 years after operation.

CONCLUSION: Pancreatoduodenectomy for adenocarcinoma in the head of pancreas can provide long-term survival in a subset of patients, particularly in the absence of lymph node metastasis.

[MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / surgery. Pancreatic Neoplasms / mortality. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy

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(PMID = 18376190.001).

[ISSN] 0003-4932

[Journal-full-title] Annals of surgery

[ISO-abbreviation] Ann. Surg.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Serum Albumin

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Total gastrectomy extended to the head of the pancreas and the liver with D4 lymphadenectomy for well-differentiated gastric carcinoma].

[Transliterated title] Gastrectomia totale estesa alla testa del pancreas e al fegato con linfoadenectomia D4 per carcinoma gastrico ben differenziato.

Adenocarcinoma of the stomach is the second most common cancer worldwide.

Early diagnosis and an adequate surgical approach could save live.

However, the role of the super-extended lymphadenectomy (D4) for gastric cancer has not been established.

[MeSH-major] Adenocarcinoma / surgery. Gastrectomy / methods. Liver / surgery. Lymph Node Excision / methods. Pancreas / surgery. Stomach Neoplasms / surgery

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(PMID = 16437917.001).

[ISSN] 2283-5423

[Journal-full-title] I supplementi di Tumori : official journal of Società italiana di cancerologia ... [et al.]

[ISO-abbreviation] Suppl Tumori

[Language] ita

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Italy

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Pancreatic adenocarcinoma.

Adenocarcinoma is the most common malignant pancreatic tumor, affecting the head of the pancreas in 60-70% of cases.

By the time of diagnosis, at least 80% of tumors are unresectable.

Helical computed tomography (CT) is very effective in detecting and staging adenocarcinoma, with a sensitivity of up to 90% for detection and an accuracy of 80-90% for staging, but it has limitations in detecting small cancers.

MDCT has been found to be at least equivalent to contrast-enhanced magnetic resonance imaging (MRI) for detecting adenocarcinoma.

Mangafodipir-enhanced MRI reveals a very high tumor-pancreas contrast, which helps in diagnosing small cancers.

It is the technique of choice for image-guided biopsy if a histologic diagnosis is required for further therapy.

[MeSH-major] Adenocarcinoma / diagnosis. Pancreatic Neoplasms / diagnosis. Tomography, X-Ray Computed

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(PMID = 17021700.001).

[ISSN] 0938-7994

[Journal-full-title] European radiology

[ISO-abbreviation] Eur Radiol

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] Germany

[Chemical-registry-number] 0 / Contrast Media

[Number-of-references] 65

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Tumour characteristics predictive of survival following resection for ductal adenocarcinoma of the head of pancreas.

AIMS: We have maintained a highly conservative policy in selecting patients with carcinoma of the head of pancreas for resection.

This study investigated our survival rates following pancreatic resection and examined clinicopathological predictors of survival.

METHODS: Sixty-two consecutive patients undergoing pancreatic resections for malignancy were identified from 1999 onwards.

Thirty-three underwent resection for pancreatic ductal adenocarcinoma and were included in our analysis, the remainder included resections for ampullary adenocarcinoma (n=20) or other malignancies (n=9).

RESULTS: Median survival following resection for ductal pancreatic adenocarcinoma was 54 months (ampullary adenocarcinomas achieved a median survival of 62 months) and thirty-day mortality was 2.7% (n=1).

CONCLUSION: Despite the advances made in the management of pancreatic cancer, tumour biology still dictates long-term survival.

[MeSH-major] Carcinoma, Ductal / mortality. Pancreatectomy / methods. Pancreatic Neoplasms / mortality

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(PMID = 17398060.001).

[ISSN] 0748-7983

[Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

[ISO-abbreviation] Eur J Surg Oncol

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Surgical treatment of pancreatic adenocarcinoma using cephalic duodenopancreatectomy (Part 2). Long term follow up after 204 cases].

[Transliterated title] Tratamiento quirúrgico del adenocarcinoma pancreático mediante duodenopancreatectomía cefálica (parte 2). Seguimiento a largo plazo tras 204 casos.

INTRODUCTION: Surgery is the accepted treatment in adenocarcinoma of the head of the pancreas; however, the long-term survival continues to be low.

The aim of this study is to define prognostic factors of long-term survival after cephalic duodenopancreatectomy due to pancreatic adenocarcinoma.

MATERIAL AND METHODS: We have collected data on the treatment of adenocarcinoma of the head of the pancreas (ADHP) by means of a cephalic duodenopancreatectomy (CDP) performed n the Bellvitge University Hospital (Barcelona) from 1991 to 2007.

CONCLUSIONS: Surgery of head of the pancreas adenocarcinoma must include an adequate lymphadectomy, and must be performed with a low morbidity and without the need of a peri-operative transfusion.

[MeSH-major] Adenocarcinoma / surgery. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy

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[Copyright] Copyright © 2010 AEC. Published by Elsevier Espana. All rights reserved.

[CommentIn] Cir Esp. 2011 Jun-Jul;89(6):411; author reply 412 [21550599.001]

(PMID = 21030012.001).

[ISSN] 1578-147X

[Journal-full-title] Cirugía española

[ISO-abbreviation] Cir Esp

[Language] spa

[Publication-type] English Abstract; Journal Article

[Publication-country] Spain

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Adenocarcinoma of the distal pancreas presenting as an intrathoracic mass.

Tumors of the pancreatic head may present with early heralding symptoms such as obstructive jaundice.

Pancreatic masses within the body or tail usually have delayed diagnosis secondary to the lack of any early findings, which, in turn, leads to a higher incidence of involvement of adjacent structures, such as the superior mesenteric artery, portal vein, or superior mesenteric vein.

The authors report a case of advanced pancreatic adenocarcinoma in which the anomalous thoracic location of the organ resulted in the tumor being resectable.

This case adds support to an aggressive approach to surgical resection of distal pancreatic tumors.

[MeSH-major] Adenocarcinoma / diagnosis. Pancreatic Neoplasms / diagnosis

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(PMID = 16971204.001).

[ISSN] 0149-7944

[Journal-full-title] Current surgery

[ISO-abbreviation] Curr Surg

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Sequential progression and intraductal spread of invasive ductal adenocarcinoma of the pancreas arising from around the main pancreatic duct.

Abdominal contrast computed tomography revealed a mass (20 x 18 mm) in the uncus of the pancreas.

Magnetic resonance cholangiopancreatography showed an abrupt narrowing with the dilatation of the peripheral main pancreatic duct (MPD) in the pancreatic head.

Histopathological and immunohistochemical examinations led to a diagnosis of sequential progression and intraductal spread of invasive ductal adenocarcinoma of the pancreas arising from around the main pancreaticduct.

[MeSH-major] Carcinoma, Pancreatic Ductal / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / pathology

[MeSH-minor] Aged. Biomarkers, Tumor / analysis. Cholangiopancreatography, Endoscopic Retrograde. Cholangiopancreatography, Magnetic Resonance. Diagnosis, Differential. Disease Progression. Female. Humans. Neoplasm Invasiveness. Pancreas / pathology. Pancreaticoduodenectomy

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(PMID = 15966196.001).

[ISSN] 0172-6390

[Journal-full-title] Hepato-gastroenterology

[ISO-abbreviation] Hepatogastroenterology

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Greece

[Chemical-registry-number] 0 / Biomarkers, Tumor

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Long-term outcome of biliary and duodenal stents in palliative treatment of patients with unresectable adenocarcinoma of the head of pancreas.

BACKGROUND: Life expectancy in patients with unresectable pancreatic cancer has improved by using new chemotherapeutic regimens.

AIM: To evaluate the incidence of biliary and duodenal stenoses as well as technical success and short- and long-term patency of endoscopically deployed stents in patients with unresectable pancreatic cancer.

PATIENTS AND METHODS: All consecutive patients with unresectable cancer of the pancreatic head seen between January 1999 and September 2003 in our center were retrospectively studied.

RESULTS: One hundred patients, median age 65 yr (32-85), with locally advanced (62%) or metastatic (38%) pancreatic cancer were studied.

[MeSH-major] Adenocarcinoma / complications. Biliary Tract. Cholestasis, Extrahepatic / therapy. Duodenal Obstruction / therapy. Duodenum. Palliative Care. Pancreatic Neoplasms / complications. Stents

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[CommentIn] Am J Gastroenterol. 2006 Apr;101(4):743-5 [16635222.001]

(PMID = 16635221.001).

[ISSN] 0002-9270

[Journal-full-title] The American journal of gastroenterology

[ISO-abbreviation] Am. J. Gastroenterol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Cephalic pancreaticoduodenectomy is the best treatment for cephalic pancreas cancers.

We report the case of a 40 old woman who underwent cephalic pancreaticoduodenectomy for an adenocarcinoma of pancreas head.

This case report talks about the importance of angioscanner before pancreatic surgery when celiac and mesenteric angiography is not available.

[MeSH-major] Adenocarcinoma / surgery. Hepatic Artery. Ischemia / etiology. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / adverse effects

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(PMID = 16295763.001).

[ISSN] 0049-1101

[Journal-full-title] Dakar médical

[ISO-abbreviation] Dakar Med

[Language] fre

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Senegal

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Inferior branch-preserving superior head resection of the pancreas with gastric wall-covering method for intraductal papillary mucinous adenoma.

Intraductal papillary mucinous neoplasm (IPMN) of the pancreas showed significantly less aggressive pathologic features compared with common pancreatic cancer.

Therefore, several organ-preserving techniques, including duodenum-preserving pancreatic head resection, have been advocated in surgical procedures for IPMN.

We describe a surgical technique of superior head resection of the pancreas with inferior branch preservation followed by a gastric wall-covering method for the prevention of pancreatic leakage in patients with IPMN of the pancreas head.

[MeSH-major] Adenocarcinoma, Mucinous / surgery. Carcinoma, Pancreatic Ductal / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / surgery. Stomach / surgery

[MeSH-minor] Abdominal Pain / diagnosis. Abdominal Pain / etiology. Aged. Anastomosis, Surgical. Cholangiopancreatography, Endoscopic Retrograde / methods. Follow-Up Studies. Humans. Immunohistochemistry. Male. Neoplasm Staging. Risk Assessment. Treatment Outcome

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(PMID = 16720158.001).

[ISSN] 0002-9610

[Journal-full-title] American journal of surgery

[ISO-abbreviation] Am. J. Surg.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Serum C-reactive protein concentration and the prognosis of ductal adenocarcinoma of the head of pancreas.

BACKGROUND: The prognostic role of serum C-reactive protein in pancreatic cancer has received increasing attention; however the confounding effects of biliary obstruction have not been addressed in previous studies.

We sought to determine the prognostic importance of serum CRP prior to biliary intervention in the prognosis of pancreatic adenocarcinoma.

METHODS: A retrospective case note review of patients diagnosed with pancreatic cancer between 2001 and 2006.

CONCLUSION: Raised serum C-reactive protein concentration at the time of presentation of advanced pancreatic cancer carries a poor prognosis independent of biliary tract obstruction.

[MeSH-major] C-Reactive Protein / analysis. Carcinoma, Pancreatic Ductal / blood. Pancreatic Neoplasms / blood

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(PMID = 19128923.001).

[ISSN] 1532-2157

[Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

[ISO-abbreviation] Eur J Surg Oncol

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Chemical-registry-number] 9007-41-4 / C-Reactive Protein

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Adenosquamous carcinoma of the pancreas.

BACKGROUND/AIMS: Adenosquamous carcinoma (ASC) of the pancreas is rare and correct preoperative diagnosis is difficult.

Case reports of ASC of the pancreas are sporadic and have typically employed small series.

This study investigated the clinicopathological features of 7 cases of ASC of the pancreas and reviewed the pertinent literature to elucidate this rare disease.

METHODOLOGY: Seven patients (4 men and 3 women; age range 38-79 years; median 66 years) with ASC of the pancreas who underwent surgical treatment at Chang Gung Memorial Hospital between February 1993 and April 2000 were retrospectively reviewed.

The tumors were located at the head of the pancreas in 4 patients (57.1%), at the body in 2, and at the tail in 2.

CONCLUSIONS: Patients with ASC present symptoms similar to those of adenocarcinoma of the pancreas.

[MeSH-major] Carcinoma, Adenosquamous / pathology. Pancreatic Neoplasms / pathology

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[Copyright] Copyright (c) 2005 S. Karger AG, Basel.

(PMID = 16172546.001).

[ISSN] 0012-2823

[Journal-full-title] Digestion

[ISO-abbreviation] Digestion

[Language] eng

[Publication-type] Journal Article

[Publication-country] Switzerland

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Inferior head resection of the pancreas for intraductal papillary mucinous neoplasms.

Thus, a variety of types of partial pancreatic resections have been advocated for treating these low-grade malignant tumors.

METHODS: We performed a retrospective review of the clinicopathologic features and surgical outcome in 15 patients who underwent inferior head resection for IPMN at the Chiba University Hospital and National Cancer Center Hospital East between July 1994 and January 2007.

Subsequent pancreatoduodenectomy was performed in one patient because of noninvasive carcinoma with multiple mucous lakes in the pancreatic parenchyma.

Pancreatic fistula occurred in 7 (47%) patients.

Two patients died of pancreatic ductal adenocarcinoma, 30 and 78 months after inferior head resection.

CONCLUSIONS: Pancreatic endocrine and exocrine function was well preserved after inferior head resection.

Pancreatic fistula occurred more frequently after inferior head resection than with conventional pancreatoduodenectomy.

[MeSH-major] Adenocarcinoma, Mucinous / surgery. Carcinoma, Pancreatic Ductal / surgery. Carcinoma, Papillary / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / surgery

[MeSH-minor] Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Retrospective Studies. Treatment Outcome

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(PMID = 19727540.001).

[ISSN] 1868-6982

[Journal-full-title] Journal of hepato-biliary-pancreatic sciences

[ISO-abbreviation] J Hepatobiliary Pancreat Sci

[Language] eng

[Publication-type] Comparative Study; Journal Article; Multicenter Study

[Publication-country] Japan

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

PATIENTS AND METHODS: Between August 2000 and April 2002 laparoscopic gastric and biliary bypass concurrently or alone was attempted in 19 consecutive patients with unresectable carcinoma of the head of the pancreas, adenocarcinoma of the stomach, cholangiocarcinoma of the distal common bile duct, or adenocarcinoma of the duodenum.

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(PMID = 16108739.001).

[ISSN] 1092-6429

[Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A

[ISO-abbreviation] J Laparoendosc Adv Surg Tech A

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Rectal cancer metastasis to the head of the pancreas treated with pancreaticoduodenectomy.

We report a case of a 50-year-old man who developed metastatic pancreatic cancer from a primary rectal cancer that had been curatively removed 3 years previously.

The patient presented with a tumor that occupied the head of the pancreas, associated with obstructive jaundice, but the main pancreatic duct was not dilated.

The patient was initially diagnosed as having primary pancreatic cancer.

Cytological examination of the bile was conclusive for the presence of adenocarcinoma.

For 1 year, local disease progression was slow and no distant metastases developed; therefore, the initial diagnosis of pancreatic cancer was questioned.

On histology, including immunohistochemical staining for cytokeratin 20 (positive) and cytokeratin 7 (negative), the tumor was shown to be a metastatic pancreatic carcinoma that had originated from the original rectal cancer.

[MeSH-major] Pancreatic Neoplasms / secondary. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy. Rectal Neoplasms / pathology

[MeSH-minor] Angiography. Cholangiopancreatography, Magnetic Resonance. Diagnosis, Differential. Fatal Outcome. Humans. Immunohistochemistry. Male. Middle Aged

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(PMID = 18040627.001).

[ISSN] 0944-1166

[Journal-full-title] Journal of hepato-biliary-pancreatic surgery

[ISO-abbreviation] J Hepatobiliary Pancreat Surg

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Japan

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Cystic neoplasia of the pancreas: pathology and biology.

In contrast with solid tumors, most of which are invasive ductal adenocarcinoma with dismal prognosis, cystic lesions of the pancreas are often either benign or low-grade indolent neoplasia.

For this reason, pancreatic cysts with mucinous differentiation ought to be evaluated carefully, preferably by experts familiar with subtle evidences of malignancy in these tumors.

The presence of ovarian-type stroma has now almost become a requirement for the diagnosis of MCN, and when defined as such, MCN is seen almost exclusively in women of perimenopausal age group as thick-walled multilocular cystic mass in the tail of the pancreas in contrast with IPMN which afflicts an elder population, both genders in almost equal numbers, and occur predominantly in the head of the organ.

SPT holds a distinctive place among pancreatic neoplasia because of its highly peculiar characteristics, undetermined cell lineage, occurrence almost exclusively in young females, association with beta-catenin pathway, and also by being a very low-grade curable malignancy.

In conclusion, cystic lesions in the pancreas constitute a biologically and pathologically diverse category most (but not all) of which are either benign or treatable diseases; however, a substantial subset, especially mucinous ones, has malignant potential that requires careful analysis.

[MeSH-major] Adenoma / pathology. Carcinoma in Situ / pathology. Neoplasms, Cystic, Mucinous, and Serous / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / pathology. Precancerous Conditions / pathology

[MeSH-minor] Adenocarcinoma, Mucinous / mortality. Adenocarcinoma, Mucinous / pathology. Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Papillary / mortality. Carcinoma, Papillary / pathology. Cystadenoma / pathology. Cystadenoma, Serous / pathology. Dilatation, Pathologic. Humans. Necrosis

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ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

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[Cites] Am J Surg Pathol. 2004 Aug;28(8):977-87 [15252303.001]

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(PMID = 17957438.001).

[ISSN] 1091-255X

[Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

[ISO-abbreviation] J. Gastrointest. Surg.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] United States

[Number-of-references] 19

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Single-branch resection of the pancreas.

The treatment of intraductal papillary mucinous tumors (IPMT) of the pancreas is still controversial.

In this report we describe a single-branch resection of the pancreas (SBRP), which is a new method for the removal of branch-type IPMT of the head of the pancreas.

A multilobular cystic lesion (50 x 40 mm) in the head of the pancreas was incidentally detected in an asymptomatic 40-year-old man who underwent a routine ultrasound examination.

The tumor was carefully removed along the border of the cyst and the normal parenchyma, with complete preservation of the main pancreatic duct and the common bile duct.

A pancreatic fistula developed during the postoperative period, but was well-controlled by endoscopic naso-pancreatic drainage.

SBRP is a technically feasible procedure and this operation represents a minimally invasive alternative to any other segmental resection of the pancreas.

[MeSH-major] Adenocarcinoma, Mucinous / surgery. Adenocarcinoma, Papillary / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / surgery

[MeSH-minor] Adult. Diagnosis, Differential. Diagnostic Imaging. Humans. Male

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(PMID = 15754104.001).

[ISSN] 0944-1166

[Journal-full-title] Journal of hepato-biliary-pancreatic surgery

[ISO-abbreviation] J Hepatobiliary Pancreat Surg

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Japan

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Intraductal papillary mucinous tumors of the pancreas.

Intraductal papillary mucinous neoplasms of the pancreas (IPMNs) are increasingly recognized in clinical practice.

They are a unique clinicopathologic entity that is characterized by mucin production, cystic dilation of the pancreatic ducts, and intraductal papillary growth.

Similar to invasive ductal adenocarcinoma of the pancreas, patients with IPMN generally present in the seventh or eighth decade of life with the head of the gland being the predominant disease site.

Traditionally, the diagnosis was made following an endoscopic retrograde cholangiopancreatography.

However, up to 50% of cases will have invasive cancer, and for this cohort the prognosis is more guarded.

[MeSH-major] Adenocarcinoma, Mucinous / pathology. Mucins / biosynthesis. Pancreatic Neoplasms / pathology

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(PMID = 16002842.001).

[ISSN] 0732-183X

[Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology

[ISO-abbreviation] J. Clin. Oncol.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] United States

[Chemical-registry-number] 0 / Mucins

[Number-of-references] 19

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Synchronous double invasive ductal carcinomas of the pancreas with multifocal branch duct intraductal papillary mucinous neoplasms of the pancreas].

A 52-year-old man with a history of distal gastrectomy for gastric cancer was admitted to our hospital because of jaundice.

CT scan revealed double tumors in the pancreatic head and body concomitant with multicystic lesions of the pancreas.

Final histological diagnosis was double invasive ductal carcinomas of the pancreas head and tail with multifocal branch duct intraductal papillary mucinous adenomas of the pancreas.

The present case suggests that entire pancreas might have malignant potential in patients with intraductal papillary mucinous neoplasms.

[MeSH-major] Adenocarcinoma, Mucinous / surgery. Carcinoma, Pancreatic Ductal / surgery. Carcinoma, Papillary / surgery. Neoplasms, Multiple Primary. Pancreatic Neoplasms / surgery

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(PMID = 19122428.001).

[ISSN] 0446-6586

[Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology

[ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi

[Language] jpn

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Japan

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Prognostic analysis of patients with pancreatic head adenocarcinoma less than 2 cm undergoing resection.

AIM: To investigate the differences in clinicopathological features between patients with pancreatic cancer greater or less than 2 cm situated over the pancreatic head and the prognostic factors for survival of patients with pancreatic cancer < 2 cm over the pancreatic head.

METHODS: From 1983 to 2006, 159 patients with histologically proven pancreatic adenocarcinoma (PAC) at the pancreatic head undergoing curative resection at the Department of Surgery, Chang Gung Memorial Hospital, Taipei, Taiwan were reviewed, comprising 123 cases of large (L)-PAC (tumor > 2 cm) and 36 cases of small (S)-PAC (tumor </= 2 cm).

RESULTS: One hundred and fifty-nine PAC patients, aged 16-93 years (median, 59.0 years) with a tumor at the pancreatic head undergoing intentional curative resection were investigated.

[MeSH-major] Adenocarcinoma / diagnosis. Pancreatic Neoplasms / diagnosis

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[Cites] Pancreas. 2004 Apr;28(3):235-40 [15084963.001]

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(PMID = 19750574.001).

[ISSN] 2219-2840

[Journal-full-title] World journal of gastroenterology

[ISO-abbreviation] World J. Gastroenterol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] China

[Other-IDs] NLM/ PMC2744187

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Endoscopic diagnosis of squamous cell carcinoma of the pancreas invading the stomach.

CONTEXT: Squamous cell carcinoma of the pancreas is an unusual tumor due to the absence of squamous cells in the normal pancreas.

Its clinical presentation is similar to that of adenocarcinoma of the pancreas and is usually diagnosed intraoperatively or at autopsy.

Contrast-enhanced computerized tomography revealed a heterogeneous enhancing mass in the head of pancreas and upper gastrointestinal endoscopy revealed an ulcerated polypoidal lesion in the stomach; the endoscopic biopsies taken from this region revealed infiltration of the lamina propria with malignant squamous cells.

CONCLUSION: A rare case of squamous cell carcinoma of the head of the pancreas presenting with obstructive jaundice and gastric outlet obstruction and in which diagnosis was established by endoscopic biopsies of the stomach has been described.

[MeSH-major] Carcinoma, Squamous Cell / diagnosis. Pancreatic Neoplasms / diagnosis. Stomach / pathology

[MeSH-minor] Diagnosis, Differential. Endoscopy, Gastrointestinal. Humans. Male. Middle Aged

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Genetic Alliance. consumer health - Stomach carcinoma.

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(PMID = 19287113.001).

[ISSN] 1590-8577

[Journal-full-title] JOP : Journal of the pancreas

[ISO-abbreviation] JOP

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Italy

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Hepatoid carcinoma of the pancreas combined with neuroendocrine carcinoma.

The most common sites of extrahepatic carcinoma are the stomach and ovary, but nine cases of hepatocellular differentiation of the pancreas have been reported in the literature.

We report another case of hepatoid carcinoma of the pancreas that was associated with the development of a pancreatic endocrine carcinoma in a 46-year-old man.

Serum alpha-fetoprotein (AFP) was elevated to 262.49 IU/mL and radiological examinations revealed a mass measuring 7.5 cm in diameter in the head of the pancreas.

He underwent a conventional Whipple operation, and light microscopy showed adenocarcinoma that was immunopositive for AFP, hepatocyte antigen, cytokeratin, chromogranin, synaptophysin, and alpha-1 antichymotrypsin.

Although hepatoid differentiation was not shown unequivocally histologically, other immunohistochemistry findings supported the diagnosis of hepatoid carcinoma combined with neuroendocrine carcinoma.

This report describes why hepatoid carcinoma should be considered as a differential diagnosis of a pancreatic mass, especially when serum AFP is elevated.

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(PMID = 20479919.001).

[ISSN] 2005-1212

[Journal-full-title] Gut and liver

[ISO-abbreviation] Gut Liver

[Language] eng

[Publication-type] Journal Article

[Publication-country] Korea (South)

[Other-IDs] NLM/ PMC2871600

[Keywords] NOTNLM ; Hepatoid carcinoma / Neuroendocrine carcinoma / Pancreas

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Agenesis of the dorsal pancreas and its association with pancreatic tumors.

Morphogenesis of the pancreas is a complex process; nevertheless, congenital anomalies are rare.

At embryogenesis, the pancreas develops from the endoderm-lined dorsal and ventral buds of the duodenum.

The ventral bud gives rise to the lower head and uncinate process of the pancreas; whereas, the dorsal bud gives rise to the upper head, isthmus, body, and tail of the pancreas.

Rarely, developmental failure of the dorsal pancreatic bud at embryogenesis results in the agenesis of the dorsal pancreas--neck, body, and tail.

Even rarer is the association of pancreatic tumors with agenesis of the dorsal pancreas.

In addition to citing our case, we provide a comprehensive review on agenesis of the dorsal pancreas and its association with pancreatic tumors.

[MeSH-major] Pancreas / abnormalities. Pancreatic Neoplasms / diagnosis

[MeSH-minor] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / surgery. Carcinoma, Pancreatic Ductal / diagnosis. Carcinoma, Pancreatic Ductal / surgery. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / surgery. Diagnosis, Differential. Humans. Male. Middle Aged. Tomography, X-Ray Computed

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(PMID = 19390403.001).

[ISSN] 1536-4828

[Journal-full-title] Pancreas

[ISO-abbreviation] Pancreas

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Endoscopic diagnosis of intraductal papillary-mucinous neoplasm of the pancreas by means of peroral pancreatoscopy using a small-diameter videoscope and narrow-band imaging.

BACKGROUND: Intraductal papillary-mucinous neoplasm (IPMN) is an intraductal tumor in which the mucin-producing epithelium shows proliferated papillary and a wide variety of pathological changes ranging from hyperplasia to adenocarcinoma.

We carried out the differential diagnosis of benign lesion to malignant lesion.

METHODS: Between April 2003 and May 2009, PPS using a small-diameter videoscope by means of NBI was carried out on 21 hospitalized patients with IPMN (10 cases of adenocarcinoma, 11 cases of adenoma or hyperplasia; 14 males and seven females, with a mean age of 69.4 years).

RESULTS: Fifteen focal lesions of the 16 cases in the head of the pancreas (93.7%) and four focal lesions of the five cases in the pancreatic body (80%) were observable, whereas two lesions (adenocarcinoma in the pancreatic body, and adenoma in the uncus of pancreas) were not observable.

Endoscopically, seven cases were classified as villous type and two cases as vegetative type, and nine cases were diagnosed as adenocarcinoma.

[MeSH-major] Adenocarcinoma / diagnosis. Adenoma / diagnosis. Endoscopes. Endoscopy, Digestive System / instrumentation. Pancreatic Ducts. Pancreatic Neoplasms / diagnosis

[MeSH-minor] Aged. Diagnosis, Differential. Equipment Design. Female. Humans. Hyperplasia / diagnosis. Male

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(PMID = 20447205.001).

[ISSN] 1443-1661

[Journal-full-title] Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

[ISO-abbreviation] Dig Endosc

[Language] eng

[Publication-type] Controlled Clinical Trial; Journal Article

[Publication-country] Australia

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Different approaches to assessment of lymph nodes and surgical margin status in patients with ductal adenocarcinoma of the pancreas treated with pancreaticoduodenectomy.

AIM: To develop a method of gross examination of pancreaticoduodenectomy specimens with pancreatic ductal adenocarcinoma, allowing adequate assessment of the entire pancreatic surface as a surgical margin, which would not affect the lymph node yield.

(1) period 2006-2007, when the pancreatic surface (except for the transection margin and superior mesenteric artery margin) was not examined;.

(2) period January-September 2008, when the posterior pancreatic surface (posterior circumferential radial margin) was examined using an improved method based on sampling of 2.0-2.5 mm thick consecutive slices perpendicular to the duodenal axis; and (3) period October 2008 - June 2009, when the whole surface of the pancreatic head was sampled using the approach mentioned above.

CONCLUSIONS: The newly proposed approach allowed adequate assessment of the entire pancreatic head surface as a surgical margin and reduced the risk of under-detection of R1 status.

[MeSH-major] Carcinoma, Pancreatic Ductal / secondary. Lymph Nodes / pathology. Pancreatic Neoplasms / pathology. Pancreaticoduodenectomy

[MeSH-minor] Aged. Female. Humans. Lymphatic Metastasis / diagnosis. Male. Middle Aged. Neoplasm, Residual. Retrospective Studies

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(PMID = 20085515.001).

[ISSN] 1465-3931

[Journal-full-title] Pathology

[ISO-abbreviation] Pathology

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] England

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Invasive ductal carcinoma of the pancreas showing exophytic growth.

BACKGROUND: Invasive pancreatic carcinoma generally appears as poorly defined mass reflecting the infiltrative growth.

We aimed to identify the histological and immunohistochemical features in a rare case of pancreatic carcinoma showing exophytic growth.

METHODS: A 67-year-old woman presented with a mass of 5.0 cm in diameter in the pancreatic head.

Magnetic resonance cholangiopancreatography revealed neither encasement nor dilation of the main pancreatic duct.

An incorrect preoperative diagnosis was made of solid pseudopapillary tumor of the pancreas.

RESULTS: The head of the pancreas contained a well-circumscribed encapsulated mass of 5.0 cm in diameter, comprising 50% adenocarcinoma, with mucinous carcinoma in the center and anaplastic carcinoma at the periphery.

[MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoma, Pancreatic Ductal / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / pathology

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(PMID = 19208524.001).

[ISSN] 1499-3872

[Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT

[ISO-abbreviation] HBPD INT

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] China

[Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Mucin-1

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Intraductal papillary-mucinous neoplasms and mucinous cystic neoplasms of the pancreas differentiated by ovarian-type stroma.

BACKGROUND: Intraductal papillary-mucinous neoplasms (IPMN) and mucinous cystic neoplasms (MCN) of the pancreas have similar clinicopathologic findings.

METHODS: Medical records for 77 patients with pancreatic cystic neoplasms with mucin secretion were reviewed.

RESULTS: IPMNs consisted of 32 adenomas, 12 borderline neoplasms, 13 adenocarcinomas in situ, and 13 invasive adenocarcinomas; MCNs included 6 adenomas and 1 invasive adenocarcinoma.

The location of the pancreatic mass differed, with 76% 0f IPMNs occurring in the head, while 86% of MCNs occurred in the body or tail.

Mass mean size was significantly smaller (28 mm vs 78 mm, P < .001), and mean diameter of the main pancreatic duct was larger (6.8 mm vs 3.1 mm, P < .001) in IPMN than in MCN.

Communication between the cyst and main pancreatic duct was more frequent in IPMNs (67/70) than in MCNs (1/7).

[MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma, Mucinous / pathology. Adenoma / pathology. Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Papillary / pathology. Stromal Cells / pathology

[MeSH-minor] Adult. Aged. Diagnosis, Differential. Disease Progression. Female. Humans. Male. Middle Aged. Ovary / cytology. Prognosis. Retrospective Studies. Survival Rate

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[CommentIn] Surgery. 2007 Apr;141(4):545-6 [17383536.001]

(PMID = 16934608.001).

[ISSN] 0039-6060

[Journal-full-title] Surgery

[ISO-abbreviation] Surgery

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Recurrent invasive intraductal papillary mucinous carcinoma of the pancreas mimicking pott disease: review of the literature.

We report an unusual case of cancer recurrence in an 86-year-old woman who had undergone a pancreaticoduodenectomy for a large IPMN in the head of the pancreas.

Final pathological evaluation of the resected pancreas found a component of in situ and invasive ductal adenocarcinoma without lymph node involvement.

Nine years later, the patient developed a retroperitoneal psoas abscess that was misdiagnosed as tuberculous spondylitis (Pott disease) but was proven to be recurrent mucinous adenocarcinoma of pancreatic origin.

[MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Papillary / pathology. Neoplasm Recurrence, Local / pathology. Pancreatic Neoplasms / pathology. Tuberculosis, Spinal / diagnosis

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(PMID = 16628089.001).

[ISSN] 1536-4828

[Journal-full-title] Pancreas

[ISO-abbreviation] Pancreas

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Long term morbidity of neoadjuvant chemoradiation for pancreatic head adenocarcinoma.

PURPOSE: To report the long term risks of neoadjuvant chemoradiation (NCRT) after duodenopancreatectomy (DP) for adenocarcinoma of the head of pancreas.

METHODS: Between January 1996 and December 2002, 26 patients with biopsy-proven adenocarcinoma of the head of pancreas were treated by this combination of therapies.

[MeSH-major] Adenocarcinoma / epidemiology. Pancreatic Neoplasms / epidemiology

[MeSH-minor] Antineoplastic Agents / therapeutic use. Biopsy. Follow-Up Studies. Humans. Morbidity. Neoadjuvant Therapy. Pancreas / pathology. Pancreas / ultrasonography. Pancreaticoduodenectomy. Retrospective Studies. Survival Rate. Time Factors. Treatment Outcome

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(PMID = 16305820.001).

[ISSN] 0748-7983

[Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

[ISO-abbreviation] Eur J Surg Oncol

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] England

[Chemical-registry-number] 0 / Antineoplastic Agents

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Endoscopic ultrasound-guided fine-needle aspiration cytology in the diagnosis of intraductal papillary mucinous neoplasms of the pancreas. A study of 8 cases.

CONTEXT: Intraductal papillary mucinous neoplasm (IPMN) is an increasingly recognized neoplasm of the pancreas, accounting for 5% of pancreatic neoplasms, it is considered difficult to diagnose by fine-needle aspiration (FNA) cytology.

OBJECTIVE: The aim of this study was to investigate the role of EUS-guided FNA cytology in the diagnosis of IPMN of the pancreas.

EUS/clinical findings, macroscopic/microscopic features of cell blocks and smears, and immunocytochemical stains accompanied by histopathologic diagnosis were recorded and studied.

RESULTS: EUS revealed hypoechoic masses in the head of pancreas (n=6) and in the body/tail (n=2), measuring from 16.6 to 35.8 mm.

In all cases, the hypoechoic mass had a distinctive distribution, involving the main pancreatic duct and/or the associated large branch ducts while intraductal nodules or multiple cysts were detected.

The histological diagnosis confirmed the FNA cytology diagnosis: 3 malignant IPMNs, 2 benign IPMNs and 3 borderline IPMNs.

CONCLUSIONS: The characteristic pre-operative EUS findings and cytomorphologic features, in addition to the immunocytochemical profile, were accurate indications and coincided with the final/post-operative histological diagnosis of IPMN.

[MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Papillary / diagnosis. Adenocarcinoma, Papillary / pathology. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / pathology

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(PMID = 17993724.001).

[ISSN] 1590-8577

[Journal-full-title] JOP : Journal of the pancreas

[ISO-abbreviation] JOP

[Language] eng

[Publication-type] Journal Article

[Publication-country] Italy

[Chemical-registry-number] 0 / Mucins; EC 2.7.10.1 / Receptor, ErbB-2

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Gastrointestinal stromal tumor of the stomach, concurrent with pancreatic adenocarcinoma].

The paper presents the data available in the literature and the authors' own data on a concomitance gastrointestinal tumor of the stomach and cancer of the pancreas head, which developed in a 56-year-old patient.

A morphological (histological and immunohistochemical) study has established the spindle-cell type of a gastrointestinal tumor that expresses Vimentin, as well as CD 34, CD 117, and pancreatic ductal adenocarcinoma.

[MeSH-major] Gastrointestinal Stromal Tumors / diagnosis. Neoplasms, Multiple Primary / diagnosis. Pancreatic Neoplasms / diagnosis

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(PMID = 17722598.001).

[ISSN] 0004-1955

[Journal-full-title] Arkhiv patologii

[ISO-abbreviation] Arkh. Patol.

[Language] rus

[Publication-type] Case Reports; English Abstract; Journal Article; Review

[Publication-country] Russia (Federation)

[Chemical-registry-number] 0 / Antigens, CD34; 0 / Vimentin; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit

[Number-of-references] 22

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Small pancreatic cancer with pancreas divisum preoperatively diagnosed by pancreatic juice cytology.

We present a case of small pancreatic head cancer with pancreas divisum preoperatively diagnosed by pancreatic juice cytology.

A 60-year-old woman was referred to our hospital for evaluation of a dilated main pancreatic duct (MPD).

A small and poorly reproducible low-echoic lesion in the pancreas was suspected by ultrasonography (US) and endoscopic ultrasonography (EUS).

Magnetic resonance cholangiopancreatography (MRCP) failed to visualize the ventral pancreatic duct, and the upstream dorsal pancreatic duct was dilated.

Endoscopic retrograde cholangiopancreatography (ERCP) was indicative of pancreas divisum, and complete obstruction of the MPD in the pancreatic head was seen.

Cytology of pancreatic juice obtained from the dorsal pancreas after minor papilla sphincterotomy revealed the presence of adenocarcinoma cells.

Pancreatoduodenectomy was performed under the diagnosis of pancreatic head cancer with pancreas divisum.

Histological examination revealed moderately-differentiated tubular adenocarcinoma 20 mm in diameter, located in the pancreatic head.

Dilatation of the dorsal pancreatic duct is sometimes observed in cases with pancreas divisum without the presence of tumors.

When pancreatic duct stenosis also exists in such cases, even if a tumor is not clearly visualized by diagnostic imaging, vigorous examinations such as pancreatic juice cytology are recommended to establish an accurate diagnosis.

[MeSH-major] Pancreas / abnormalities. Pancreatic Neoplasms / diagnosis

[MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenocarcinoma / ultrasonography. Cholangiopancreatography, Endoscopic Retrograde. Female. Humans. Middle Aged. Pancreatic Juice / cytology

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(PMID = 19755770.001).

[ISSN] 1349-7235

[Journal-full-title] Internal medicine (Tokyo, Japan)

[ISO-abbreviation] Intern. Med.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Japan

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Lipomatous pseudohypertrophy of the pancreas: a clinicopathologically distinct entity.

OBJECTIVES: Owing to the challenges in obtaining pancreatic biopsies, pancreatic resection for presumed malignancy is often performed without histological confirmation.

One such condition, which is poorly defined in the literature, is referred to as lipomatous pseudohypertrophy (LPH) of the pancreas.

RESULTS: Four patients underwent surgical resection, 3 of which were diagnosed preoperatively by radiology as having ductal adenocarcinoma.

The fifth patient has been placed on watchful waiting.Two tumors were in the pancreatic head, one in the tail, one in the uncinate process, and one demonstrated diffuse involvement.

Within the adipose tissue, scattered microscopic foci of pancreatic parenchyma could be seen.

CONCLUSION: Lipomatous pseudohypertrophy of the pancreas is a distinct entity characterized by localized/diffuse replacement of pancreatic parenchyma with mature adipose tissue.

It forms a pseudotumor that may be difficult to distinguish clinically from pancreatic adenocarcinoma.

This entity should be considered when evaluating patients with a new diagnosis of a hypodense pancreatic neoplasm on imaging.

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[Cites] Acta Gastroenterol Belg. 1990 May-Jun;53(3):315-22 [2077797.001]

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(PMID = 19904221.001).

[ISSN] 1536-4828

[Journal-full-title] Pancreas

[ISO-abbreviation] Pancreas

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / P50 CA062924; None / None / / P50 CA062924-12; United States / NCI NIH HHS / CA / P50 CA062924-12; United States / NCI NIH HHS / CA / P50-CA62924

[Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural

[Publication-country] United States

[Other-IDs] NLM/ NIHMS317488; NLM/ PMC3164317

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Clinical and pathological analysis of 114 cases with non-ductal pancreatic adenocarcinoma occupying lesions].

OBJECTIVE: To improve the diagnosis and treatment of non-ductal pancreatic adenocarcinoma-occupying lesions.

METHODS: A retrospective analysis was made for 114 cases of pancreatic non-ductal adenocarcinoma-occupying pathologically confirmed lesions. RESULTS:.

(4) pancreaticoduodenectomy was performed in 26 patients, distal pancreatectomy in 53, tumor enucleation in 15, segmental pancreatectomy in 9, partial resection in 3, duodenum-preserving pancreatic head resection in 1 and palliative surgery (either cholecystojejunostomy anastomosis or gastrojejunostomy) in 7;.

(5) pathologic analysis revealed 35 solid pseudopapillary neoplasm of pancreas, 28 pancreatic endocrine tumors, 18 focal chronic pancreatitis, 11 serous cystic neoplasms, 9 mucinous cystic neoplasms, 4 pancreatic cysts, 3 acinar cell carcinomas, 2 pancreatic cavernous hemangiomas, 1 sarcoma of pancreas, 1 sarcomatoid carcinoma of pancreas, 1 pancreatic schwannoma and 1 pancreatic neuroblastoma.

CONCLUSION: The non-ductal pancreatic adenocarcinoma-occupying lesions have no specific clinical presentation or serum tumor marker.

[MeSH-major] Pancreatic Neoplasms / pathology

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(PMID = 20646423.001).

[ISSN] 0376-2491

[Journal-full-title] Zhonghua yi xue za zhi

[ISO-abbreviation] Zhonghua Yi Xue Za Zhi

[Language] chi

[Publication-type] English Abstract; Journal Article

[Publication-country] China

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Intraductal papillary mucinous tumor of the pancreas associated with autosomal dominant polycystic kidney disease.

CT showed multiple cysts in the liver and both kidneys along with ADPKD and a cystic mass, 4 cm in diameter, in the pancreatic head.

The main pancreatic duct was dilated to 1 cm in diameter.

Histologic examination revealed a multiloculated cystic tumor filled with mucin in the head of the pancreas.

Microscopically, the tumor was diagnosed as adenocarcinoma and was found to have invaded the main pancreatic duct.

Although, in addition to our case, only seven cases with association between ADPKD and malignant neoplasms have been reported, five of these cases had neoplasms arising from the pancreas.

Therefore, we suggest that some genetic interactions may exist between ADPKD and pancreatic carcinogenesis.

[MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Carcinoma, Pancreatic Ductal / diagnosis. Pancreatic Neoplasms / diagnosis. Pancreaticoduodenectomy / methods. Polycystic Kidney, Autosomal Dominant / diagnosis

[MeSH-minor] Abdominal Pain / diagnosis. Abdominal Pain / etiology. Acute Disease. Adult. Biopsy, Needle. Follow-Up Studies. Humans. Immunohistochemistry. Male. Pancreatitis / diagnosis. Pancreatitis / etiology. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome

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[Cites] J Gastroenterol. 2001 Jun;36(6):422-8 [11428590.001]

[Cites] Br J Surg. 2003 Oct;90(10):1244-9 [14515294.001]

[Cites] Gastroenterology. 1997 Jun;112(6):2104-7 [9178704.001]

[Cites] Am J Med. 1977 Apr;62(4):616-26 [851133.001]

[Cites] Adv Nephrol Necker Hosp. 1985;14:1-20 [2983516.001]

(PMID = 15985242.001).

[ISSN] 1091-255X

[Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

[ISO-abbreviation] J. Gastrointest. Surg.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Pancreatic adenocarcinoma: dynamic 64-slice helical CT with perfusion imaging.

Thus, in lesions of the tissues of the pancreas, this offers to increase the accuracy of CT diagnosis.

In this study, our aim was to explore the perfusion characteristics of normal pancreas and pancreatic adenocarcinoma.

METHODS: Dynamic 64-slice helical CT was conducted in 36 patients with non-pancreatic disease and in 40 patients with histopathologically proven pancreatic adenocarcinoma.

RESULTS: There was no significant difference noted between the distribution of BF, BV, and PS values in different regions of the pancreas, namely the head, neck, body, and tail (P > 0.05).

The BF, BV, and PS of normal pancreas were recorded as 135.24 +/- 48.36 ml min(-1) 100 g(-1), 200.55 +/- 54.96 ml 100 g(-1), and 49.75 +/- 24.27 ml min(-1) 100 g(-1), respectively.

BF, BV, and PS values of the tumor tissue of pancreatic adenocarcinoma decreased significantly compared to normal pancreas (P < 0.05).

CONCLUSIONS: Normal pancreas appears homogenous on perfusion CT.

A significant decrease of BF, BV, and PS was observed in pancreatic adenocarcinoma.

Dynamic 64-slice helical CT with perfusion imaging should be considered a potential modality to increase the accuracy of CT diagnosis for pancreatic adenocarcinoma.

[MeSH-major] Adenocarcinoma / radiography. Pancreatic Neoplasms / radiography. Tomography, Spiral Computed / methods

[MeSH-minor] Case-Control Studies. Contrast Media. Female. Humans. Iohexol. Male. Middle Aged. Pancreas / blood supply. Pancreas / radiography. Pancreaticoduodenectomy. Prospective Studies

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(PMID = 19672566.001).

[ISSN] 1432-0509

[Journal-full-title] Abdominal imaging

[ISO-abbreviation] Abdom Imaging

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Contrast Media; 4419T9MX03 / Iohexol

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Solid type clear cell carcinoma of the pancreas: differential diagnosis of an unusual case and review of the literature.

Pancreatic neoplasms have been reliably classified on the basis of their histopathology and immunophenotype.

In this study, we report on a pancreatic tumor whose phenotype and genotype could not be assigned to any known tumor entity.

The tumor was observed in the pancreatic head of a 54-year-old woman.

DNA microarray analysis revealed a transcription profile clearly differing from that of normal pancreatic tissue and pancreatic ductal adenocarcinoma.

Despite metastatic behavior, the tumor displayed a more favorable course than conventional pancreatic ductal adenocarcinoma.

We suggest that this tumor be called solid type clear cell carcinoma of the pancreas.

[MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Pancreatic Neoplasms / diagnosis

[MeSH-minor] Diagnosis, Differential. Female. Gene Expression Profiling. Humans. Immunohistochemistry. Keratins / metabolism. Liver Neoplasms / diagnostic imaging. Liver Neoplasms / secondary. Microarray Analysis. Middle Aged. Mucin-1 / metabolism. Oligonucleotide Array Sequence Analysis. Reverse Transcriptase Polymerase Chain Reaction. S100 Proteins / metabolism. Tomography, Spiral Computed. Vimentin / metabolism

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[Cites] Cancer. 1998 Oct 1;83(7):1292-9 [9762928.001]

(PMID = 17453235.001).

[ISSN] 0945-6317

[Journal-full-title] Virchows Archiv : an international journal of pathology

[ISO-abbreviation] Virchows Arch.

[Language] eng

[Publication-type] Case Reports; Journal Article; Review

[Publication-country] Germany

[Chemical-registry-number] 0 / MUC1 protein, human; 0 / Mucin-1; 0 / S100 Proteins; 0 / Vimentin; 68238-35-7 / Keratins

[Number-of-references] 39

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Pancreatic ductal adenocarcinoma associated with pancreatic ductal intraepithelial neoplasia: report of a case.

BACKGROUND: The presence of pancreatic ductal intraepithelial neoplasia in patients with chronic pancreatitis is a risk factor for development of pancreatic adenocarcinoma.

METHOD: A case of pancreatic ductal adenocarcinoma associated with pancreatic ductal intraepithelial neoplasia was diagnosed in the setting of chronic pancreatitis.

RESULTS: Distal pancreatectomy combined with splenectomy was performed with a diagnosis of pancreatic body carcinoma.

Histopathological examination suggested adenocarcinoma associated with pancreatic ductal intraepithelial neoplasia.

The tumor was detected in the remaining head of the pancreas, for which a total pancreatectomy was done.

CONCLUSIONS: When a patient with pancreatic ductal intraepithelial neoplasia associated with adenocarcinoma of the pancreas in the setting of chronic pancreatitis is at an increased risk of recurrence in the remaining pancreatic parenchyma, total pancreatectomy may be feasible.

[MeSH-major] Carcinoma in Situ / pathology. Carcinoma, Pancreatic Ductal / pathology. Pancreatic Neoplasms / pathology

[MeSH-minor] Diagnosis, Differential. Follow-Up Studies. Humans. Laparoscopy. Laparotomy / methods. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasms, Multiple Primary. Pancreatectomy / methods. Splenectomy / methods. Tomography, X-Ray Computed

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[CommentIn] Hepatobiliary Pancreat Dis Int. 2008 Feb;7(1):106-7 [18234650.001]

(PMID = 17897923.001).

[ISSN] 1499-3872

[Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT

[ISO-abbreviation] HBPD INT

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] China

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Clear cell carcinoma of exocrine pancreas: a rare tumor with an unusual presentation.

Metastatic clear cell carcinomas are relatively common from primary tumors arising in the kidney, female genital tract, adrenal cortex, and lung, but they rarely occur from primary tumors of the pancreas.

We report a case of metastatic pancreatic tumor with marked clear cell changes in a 46-year-old white man presenting with a pseudocyst of the pancreas.

At laparotomy, there was a hard area in the head of the pancreas and another hard nodule was present in the omentum.

The histologic and immunohistochemical test of the excised omental nodule exhibited features consistent with clear cell carcinoma from pancreatic primary.

To our knowledge, this is the first report of a metastatic clear cell pancreatic tumor with such an unusual presentation.

[MeSH-major] Adenocarcinoma, Clear Cell / secondary. Omentum / pathology. Pancreas, Exocrine / pathology. Pancreatic Neoplasms / pathology. Pancreatic Pseudocyst / pathology

[MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Tomography, X-Ray Computed

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(PMID = 15714142.001).

[ISSN] 1536-4828

[Journal-full-title] Pancreas

[ISO-abbreviation] Pancreas

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Intraductal papillary mucinous neoplasm of pancreas: a clinicopathologic and immunohistochemical study of 19 cases].

OBJECTIVE: To study the clinicopathologic features and diagnosis of intraductal papillary mucinous neoplasm (IPMN) of the pancreas.

It affected patients in older age group (mean age = 59) and was located mainly in the head of pancreas (60%).

Histologically, the tumor consisted of papillary proliferations protruding into and expanding the pancreatic ducts.

Invasion into the surrounding pancreatic parenchyma was noted in 12 cases and chronic pancreatitis was present in 16 cases.

The prognosis after surgical resection however is better than that of conventional pancreatic adenocarcinoma.

Early recognition by radiologic examination (including ERCP) and pancreatic cytology would be helpful in early diagnosis.

[MeSH-major] Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Papillary / pathology. Immunohistochemistry / trends. Pancreatic Neoplasms / pathology

[MeSH-minor] Adaptor Proteins, Signal Transducing / analysis. Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / metabolism. Adult. Aged. Cell Cycle Proteins / analysis. Cholangiopancreatography, Endoscopic Retrograde. Female. Humans. Ki-67 Antigen / analysis. Male. Middle Aged. Pancreas / metabolism. Pancreas / pathology. Pancreatectomy. Pancreatic Ducts / metabolism. Pancreatic Ducts / pathology. Prognosis. Receptor, ErbB-2 / analysis. Treatment Outcome

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(PMID = 19094485.001).

[ISSN] 0529-5807

[Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology

[ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi

[Language] chi

[Publication-type] English Abstract; Journal Article

[Publication-country] China

[Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / CDCA5 protein, human; 0 / Cell Cycle Proteins; 0 / Ki-67 Antigen; EC 2.7.10.1 / Receptor, ErbB-2

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Multifocal pancreatic ductal adenocarcinomas concomitant with intraductal papillary mucinous neoplasms of the pancreas detected by intraoperative pancreatic juice cytology. A case report.

CONTEXT: Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas have been detected with increasing frequency as a result of the progression of diagnostic modalities.

Recently, invasive ductal carcinoma of the pancreas concomitant with IPMNs has been the focus of attention.

CASE REPORT: We report the case of a 57-year-old man with multifocal ductal carcinomas of the pancreas concomitant with IPMNs detected by intraoperative cytology.

During a follow-up for branch duct IPMNs, a stenotic lesion of the main duct in the pancreatic body was found by ERCP, and brush cytology of the stenosis revealed an adenocarcinoma.

A distal pancreatectomy was proposed; however, intraoperative pancreatic juice cytology from the pancreatic head also revealed adenocarcinoma, and a total pancreatectomy was finally carried out.

Pathological examination of the resected specimen showed multifocal ductal carcinomas and IPMNs in the distal pancreas, and invasive ductal carcinoma in the pancreatic head which had not been detected by preoperative imaging studies.

Intraoperative pancreatic juice cytology should always be performed in order to confirm the absence of carcinoma in the pancreas to be left in place after planned resection.

[MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Carcinoma, Pancreatic Ductal / diagnosis. Carcinoma, Papillary / diagnosis. Neoplasms, Multiple Primary / diagnosis. Pancreatic Juice / cytology. Pancreatic Neoplasms / diagnosis

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(PMID = 20601817.001).

[ISSN] 1590-8577

[Journal-full-title] JOP : Journal of the pancreas

[ISO-abbreviation] JOP

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Italy

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Intraductal oncocytic papillary neoplasm of the pancreas with celiac artery compression syndrome and a jejunal artery aneurysm: report of a case.

A 79-year-old woman presented with epigastralgia, and computed tomography showed a 3-cm multiloculated mass with a mural nodule in the head of the pancreas.

We made a preoperative diagnosis of intraductal papillary adenocarcinoma of the pancreatic head and performed a laparotomy.

Microscopically, the tumor had papillary intracystic growth, and was lined by plump cells with abundant eosinophilic cytoplasm, consistent with a diagnosis of intraductal oncocytic papillary neoplasm.

We discuss this recently recognized entity of papillary neoplasm of the pancreas, and the importance of managing hepatic blood flow during pancreaticoduodenectomy in celiac artery compression syndrome.

[MeSH-major] Adenocarcinoma, Papillary / surgery. Arterial Occlusive Diseases / radiography. Celiac Artery. Jejunum / blood supply. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / methods

[MeSH-minor] Abdominal Pain / diagnosis. Abdominal Pain / etiology. Aged. Aneurysm / radiography. Aneurysm / surgery. Angiography. Female. Follow-Up Studies. Humans. Risk Assessment. Severity of Illness Index. Tomography, X-Ray Computed. Treatment Outcome

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(PMID = 15622472.001).

[ISSN] 0941-1291

[Journal-full-title] Surgery today

[ISO-abbreviation] Surg. Today

[Language] eng

[Publication-type] Case Reports; Journal Article; Review

[Publication-country] Japan

[Number-of-references] 16

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Autoimmune pancreatitis presenting as simultaneous masses in the pancreatic head and gallbladder.

CONTEXT: Autoimmune pancreatitis is a rare variant of chronic pancreatitis characterized by pancreatic ductal narrowing and pancreatic parenchymal edema on computed tomography and rarely with intermittent attacks of abdominal pain.

CASE REPORT: We describe the clinical, radiographic and histopathologic aspects of a patient who presented with synchronous masses in the pancreatic head and gallbladder.

CONCLUSION: Autoimmune pancreatitis is the most common benign entity identified in patients that underwent pancreaticoduodenectomy for presumed pancreatic adenocarcinoma.

Our patient with autoimmune pancreatitis presented with simultaneous inflammatory masses in the gallbladder and pancreatic head, an association not previously reported.

If pre-operative diagnosis is not made, immunohistochemical staining of pathology specimens can confirm the diagnosis.

[MeSH-major] Autoimmune Diseases / diagnosis. Autoimmune Diseases / pathology. Gallbladder / pathology. Pancreas / pathology. Pancreatitis / diagnosis. Pancreatitis / pathology

[MeSH-minor] Acute Disease. Aged. Edema / diagnosis. Edema / pathology. Female. Humans. Immunoglobulin G / analysis. Immunoglobulin G / blood. Immunohistochemistry. Tomography, X-Ray Computed

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(PMID = 16186668.001).

[ISSN] 1590-8577

[Journal-full-title] JOP : Journal of the pancreas

[ISO-abbreviation] JOP

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Italy

[Chemical-registry-number] 0 / Immunoglobulin G

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Pancreatic resection for metastasis to the pancreas from colon and lung cancer, and osteosarcoma.

CONTEXT: Pancreatic resection for a metastatic colon, lung cancer or an osteosarcoma has rarely been reported in the literature and there is controversy regarding recurrence and the overall survival of these patients.

We herein evaluate the outcome of three patients who underwent pancreaticoduodenectomy for the aforementioned metastatic tumors to the pancreas.

One patient was asymptomatic and was diagnosed during follow-up for colon cancer.

All the pancreatic lesions were located in the head of the pancreas, and the intervals between the diagnosis of the primary cancer and the pancreatic metastases were 6, 14 and 24 months.

CONCLUSION: Pancreatic resection for metastatic disease may be suggested for selected patients, even those with limited extrapancreatic disease.

[MeSH-major] Bone Neoplasms / pathology. Colonic Neoplasms / pathology. Lung Neoplasms / pathology. Osteosarcoma / pathology. Pancreatic Neoplasms / secondary. Pancreatic Neoplasms / surgery

[MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adolescent. Female. Humans. Male. Middle Aged. Pancreatectomy / methods

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(PMID = 21068492.001).

[ISSN] 1590-8577

[Journal-full-title] JOP : Journal of the pancreas

[ISO-abbreviation] JOP

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Italy