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1. Zou YP, Li WM, Zheng F, Li FC, Huang H, Du JD, Liu HR: Intraoperative radiofrequency ablation combined with 125 iodine seed implantation for unresectable pancreatic cancer. World J Gastroenterol; 2010 Oct 28;16(40):5104-10
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  • [Title] Intraoperative radiofrequency ablation combined with 125 iodine seed implantation for unresectable pancreatic cancer.
  • AIM: To evaluate the feasibility, efficacy and safety of intraoperative radiofrequency ablation (RFA) combined with (125)iodine seed implantation for unresectable pancreatic cancer.
  • METHODS: Thirty-two patients (21 males and 11 females) at the age of 68 years (range 48-90 years) with unresectable locally advanced pancreatic cancer admitted to our hospital from January 2006 to May 2008 were enrolled in this study.
  • The tumor, 4-12 cm in diameter, located in pancreatic head of 23 patients and in pancreatic body and tail of 9 patients, was found to be unresectable during operation.
  • Diagnosis of pancreatic cancer was made through intraoperative biopsy.
  • CONCLUSION: Intraoperative RFA combined with (125)iodine seed implantation is a feasible and safe procedure for unresectable pancreatic cancer with acceptable minor complications, and can prolong the survival time of patients, especially those at stage III.
  • [MeSH-major] Adenocarcinoma / therapy. Catheter Ablation / methods. Iodine Radioisotopes / therapeutic use. Pancreatic Neoplasms / therapy. Radiotherapy / methods

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  • (PMID = 20976848.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
  • [Other-IDs] NLM/ PMC2965288
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2. Nimura Y: [Treatment of pancreatic cancer--surgical point of view]. Gan To Kagaku Ryoho; 2007 Jul;34(7):993-6
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  • [Title] [Treatment of pancreatic cancer--surgical point of view].
  • Although surgical techniques for pancreatic cancer have developed in a high level, the treatment results have not been improved and the 5 year survival rates after curative operation has been about 15% in Japan.
  • Retrospective studies on extended lymphadenectomy for ductal adenocarcinoma of the head of the pancreas revealed that extended surgery prolonged the survival for resected patients.
  • Finally, the clinical advantages of extended lymphadenectomy for pancreatic cancer was denied by several RCTs from Italy and U.S.A.
  • Further development of multidisciplinary treatments for pancreatic cancer is expected.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / surgery. Lymph Node Excision / methods. Pancreatectomy. Pancreatic Neoplasms / surgery

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  • (PMID = 17637533.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
  • [Number-of-references] 24
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3. Adsay NV, Basturk O, Thirabanjasak D: Diagnostic features and differential diagnosis of autoimmune pancreatitis. Semin Diagn Pathol; 2005 Nov;22(4):309-17
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  • [Title] Diagnostic features and differential diagnosis of autoimmune pancreatitis.
  • In about 15% to 20% of patients, the clinical stigmata of autoimmune conditions are present at the time of diagnosis, and in many others, discovered subsequently.
  • Most patients present with a pancreatic head mass, often with an accompanying stricture of the distal common bile duct, which thus radiologically resembles "pancreas cancer."
  • Elevated serum IgG4 levels are characteristic and may be very helpful in the differential diagnosis from tumors and tumor-like lesions of the pancreas which seldom result in levels above 135 mg/dL.
  • [MeSH-major] Autoimmune Diseases / diagnosis. Pancreatitis / diagnosis
  • [MeSH-minor] Adenocarcinoma / pathology. Adrenal Cortex Hormones / therapeutic use. Adult. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 16939059.001).
  • [ISSN] 0740-2570
  • [Journal-full-title] Seminars in diagnostic pathology
  • [ISO-abbreviation] Semin Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones
  • [Number-of-references] 91
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4. Matsubara N, Baba H, Okamoto A, Kurata M, Tsuruta K, Funata N, Ashizawa K: Rectal cancer metastasis to the head of the pancreas treated with pancreaticoduodenectomy. J Hepatobiliary Pancreat Surg; 2007;14(6):590-4
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  • [Title] Rectal cancer metastasis to the head of the pancreas treated with pancreaticoduodenectomy.
  • We report a case of a 50-year-old man who developed metastatic pancreatic cancer from a primary rectal cancer that had been curatively removed 3 years previously.
  • The patient presented with a tumor that occupied the head of the pancreas, associated with obstructive jaundice, but the main pancreatic duct was not dilated.
  • The patient was initially diagnosed as having primary pancreatic cancer.
  • Cytological examination of the bile was conclusive for the presence of adenocarcinoma.
  • For 1 year, local disease progression was slow and no distant metastases developed; therefore, the initial diagnosis of pancreatic cancer was questioned.
  • On histology, including immunohistochemical staining for cytokeratin 20 (positive) and cytokeratin 7 (negative), the tumor was shown to be a metastatic pancreatic carcinoma that had originated from the original rectal cancer.
  • [MeSH-major] Pancreatic Neoplasms / secondary. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy. Rectal Neoplasms / pathology
  • [MeSH-minor] Angiography. Cholangiopancreatography, Magnetic Resonance. Diagnosis, Differential. Fatal Outcome. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 18040627.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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5. Demirkan B, Unek IT, Eriksson B, Akarsu M, Durak H, Sağol O, Obuz F, Binicier C, Füzün M, Alakavuklar M: A patient with nonfunctional pancreatic neuroendocrine tumor and incidental metachronous colon carcinoma detected by positron emission tomography: case report. Turk J Gastroenterol; 2009 Sep;20(3):214-9
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  • [Title] A patient with nonfunctional pancreatic neuroendocrine tumor and incidental metachronous colon carcinoma detected by positron emission tomography: case report.
  • Pancreatic neuroendocrine tumors constitute about 2% of all gastrointestinal neoplasms.
  • Approximately half of the pancreatic euroendocrine tumors are nonfunctional.
  • Due to lack of specific symptoms, most patients with nonfunctional pancreatic neuroendocrine tumors present with locally advanced or metastatic disease.
  • Colon carcinoma ranks third in frequency among primary sites of cancer in both men and women in western countries.
  • Presence of a metachronous colon adenocarcinoma in a patient with nonfunctional pancreatic neuroendocrine tumor has not been reported before.
  • We present a patient who had an asymptomatic mass in the head of the pancreas, detected by ultrasonography in 1996.
  • In 2002, after the diagnosis of an unresectable, nonfunctional pancreatic neuroendocrine tumor, interferon alpha- 2b and octreotide were started.
  • [MeSH-major] Adenocarcinoma / radionuclide imaging. Colonic Neoplasms / radionuclide imaging. Neoplasms, Second Primary / radionuclide imaging. Neuroendocrine Tumors / radionuclide imaging. Pancreatic Neoplasms / radionuclide imaging. Positron-Emission Tomography

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  • (PMID = 19821205.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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6. Delpero JR, Turrini O: [Ductal adenocarcinoma of the head of the pancreas: a critical study of R1 resection rates]. Bull Cancer; 2008 Dec;95(12):1193-8
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  • [Title] [Ductal adenocarcinoma of the head of the pancreas: a critical study of R1 resection rates].
  • Complete resection (R0) remains the only potentially curative treatment of ductal adenocarcinoma of the pancreas.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Pancreatic Ductal / surgery. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Humans. Neoadjuvant Therapy. Neoplasm Recurrence, Local. Neoplasm, Residual. Pancreas / pathology. Pancreas / surgery. Pancreatectomy. Prognosis

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  • (PMID = 19091653.001).
  • [ISSN] 1769-6917
  • [Journal-full-title] Bulletin du cancer
  • [ISO-abbreviation] Bull Cancer
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 29
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7. Kuroki T, Tajima Y, Tsutsumi R, Mishima T, Kitasato A, Adachi T, Kanematsu T: Inferior branch-preserving superior head resection of the pancreas with gastric wall-covering method for intraductal papillary mucinous adenoma. Am J Surg; 2006 Jun;191(6):823-6
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  • [Title] Inferior branch-preserving superior head resection of the pancreas with gastric wall-covering method for intraductal papillary mucinous adenoma.
  • Intraductal papillary mucinous neoplasm (IPMN) of the pancreas showed significantly less aggressive pathologic features compared with common pancreatic cancer.
  • Therefore, several organ-preserving techniques, including duodenum-preserving pancreatic head resection, have been advocated in surgical procedures for IPMN.
  • We describe a surgical technique of superior head resection of the pancreas with inferior branch preservation followed by a gastric wall-covering method for the prevention of pancreatic leakage in patients with IPMN of the pancreas head.
  • [MeSH-major] Adenocarcinoma, Mucinous / surgery. Carcinoma, Pancreatic Ductal / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / surgery. Stomach / surgery
  • [MeSH-minor] Abdominal Pain / diagnosis. Abdominal Pain / etiology. Aged. Anastomosis, Surgical. Cholangiopancreatography, Endoscopic Retrograde / methods. Follow-Up Studies. Humans. Immunohistochemistry. Male. Neoplasm Staging. Risk Assessment. Treatment Outcome

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  • (PMID = 16720158.001).
  • [ISSN] 0002-9610
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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8. Obana T, Fujita N, Noda Y, Kobayashi G, Ito K, Horaguchi J, Takasawa O, Tsuchiya T, Sawai T: Small pancreatic cancer with pancreas divisum preoperatively diagnosed by pancreatic juice cytology. Intern Med; 2009;48(18):1661-6
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  • [Title] Small pancreatic cancer with pancreas divisum preoperatively diagnosed by pancreatic juice cytology.
  • We present a case of small pancreatic head cancer with pancreas divisum preoperatively diagnosed by pancreatic juice cytology.
  • A 60-year-old woman was referred to our hospital for evaluation of a dilated main pancreatic duct (MPD).
  • A small and poorly reproducible low-echoic lesion in the pancreas was suspected by ultrasonography (US) and endoscopic ultrasonography (EUS).
  • Magnetic resonance cholangiopancreatography (MRCP) failed to visualize the ventral pancreatic duct, and the upstream dorsal pancreatic duct was dilated.
  • Endoscopic retrograde cholangiopancreatography (ERCP) was indicative of pancreas divisum, and complete obstruction of the MPD in the pancreatic head was seen.
  • Cytology of pancreatic juice obtained from the dorsal pancreas after minor papilla sphincterotomy revealed the presence of adenocarcinoma cells.
  • Pancreatoduodenectomy was performed under the diagnosis of pancreatic head cancer with pancreas divisum.
  • Histological examination revealed moderately-differentiated tubular adenocarcinoma 20 mm in diameter, located in the pancreatic head.
  • Dilatation of the dorsal pancreatic duct is sometimes observed in cases with pancreas divisum without the presence of tumors.
  • When pancreatic duct stenosis also exists in such cases, even if a tumor is not clearly visualized by diagnostic imaging, vigorous examinations such as pancreatic juice cytology are recommended to establish an accurate diagnosis.
  • [MeSH-major] Pancreas / abnormalities. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenocarcinoma / ultrasonography. Cholangiopancreatography, Endoscopic Retrograde. Female. Humans. Middle Aged. Pancreatic Juice / cytology

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  • (PMID = 19755770.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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9. Tomimaru Y, Ishikawa O, Ohigashi H, Eguchi H, Yamada T, Sasaki Y, Miyashiro I, Ohue M, Yano M, Uehara H, Nakaizumi A, Imaoka S: Advantage of pancreaticogastrostomy in detecting recurrent intraductal papillary mucinous carcinoma in the remnant pancreas: a case of successful re-resection after pancreaticoduodenectomy. J Surg Oncol; 2006 May 1;93(6):511-5
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  • [Title] Advantage of pancreaticogastrostomy in detecting recurrent intraductal papillary mucinous carcinoma in the remnant pancreas: a case of successful re-resection after pancreaticoduodenectomy.
  • Recently there has been an increase in the number of case reports detailing the recurrence of cancer in the pancreatic remnants following surgical resection of intraductal papillary mucinous carcinoma (IPMC) of the pancreas.
  • A 68-year-old man underwent PD for IPMC of the pancreatic head, and the cut margin of the pancreatic duct was diagnosed as having no cancer but moderately dysplastic epithelium by an intraoperative frozen section of histology.
  • Eight years and 6 months later, during a routine follow-up examination, duct dilation of the remnant pancreas was detected by magnetic resonance imaging (MRI).
  • Upon examination by endoscopic gastroscopy, the anastomotic site was found to be covered with a large amount of mucin from which we easily obtained both cytologic and biopsied specimens, which subsequently proved positive for cancer.
  • In line with our diagnosis of recurrent IPMC, the patient underwent a second surgery (resection of the remnant pancreas, total pancreatectomy) and postoperative histology confirmed that indeed the patient had experienced recurrent IPMC with no nodal involvement or invasion beyond the pancreatic confines.
  • Based on this experience, we decided to recommend PG for all patients deemed to be at high risk for the recurrence of cancer in the pancreatic remnants following PD for IPMC of the pancreatic head.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / surgery. Gastrostomy. Neoplasm Recurrence, Local / surgery. Pancreatic Ducts / surgery. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy
  • [MeSH-minor] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / surgery. Aged. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / surgery. Follow-Up Studies. Gastroscopy. Humans. Magnetic Resonance Imaging. Male. Pancreatectomy. Reoperation

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 16615155.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Tapper EB, Martin D, Adsay NV, Kooby D, Kalb B, Sarmiento JM: An MRI-driven practice: a new perspective on MRI for the evaluation of adenocarcinoma of the head of the pancreas. J Gastrointest Surg; 2010 Aug;14(8):1292-7
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  • [Title] An MRI-driven practice: a new perspective on MRI for the evaluation of adenocarcinoma of the head of the pancreas.
  • OBJECTIVES: The purpose of the study was to describe the MRI-driven management of masses at the head of the pancreas.
  • RESULTS: Between 2004 and 2008, we have treated 124 patients for a radiographic diagnosis of adenocarcinoma of the head of the pancreas.
  • This diagnosis was correct in 96.0% of the time.
  • CONCLUSION: MRI is a useful tool in the preoperative imaging of pancreatic head lesions that is highly sensitive and very specific for resectable disease.
  • [MeSH-major] Adenocarcinoma / diagnosis. Magnetic Resonance Imaging / methods. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Pancreaticoduodenectomy. Prognosis. Reproducibility of Results. Retrospective Studies. Sensitivity and Specificity. Time Factors

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  • (PMID = 20467829.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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11. Jung JY, Kim YJ, Kim HM, Kim HJ, Park SW, Song SY, Chung JB, Kang CM, Pyo JY, Yang WI, Bang S: Hepatoid carcinoma of the pancreas combined with neuroendocrine carcinoma. Gut Liver; 2010 Mar;4(1):98-102
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  • [Title] Hepatoid carcinoma of the pancreas combined with neuroendocrine carcinoma.
  • The most common sites of extrahepatic carcinoma are the stomach and ovary, but nine cases of hepatocellular differentiation of the pancreas have been reported in the literature.
  • We report another case of hepatoid carcinoma of the pancreas that was associated with the development of a pancreatic endocrine carcinoma in a 46-year-old man.
  • Serum alpha-fetoprotein (AFP) was elevated to 262.49 IU/mL and radiological examinations revealed a mass measuring 7.5 cm in diameter in the head of the pancreas.
  • He underwent a conventional Whipple operation, and light microscopy showed adenocarcinoma that was immunopositive for AFP, hepatocyte antigen, cytokeratin, chromogranin, synaptophysin, and alpha-1 antichymotrypsin.
  • Although hepatoid differentiation was not shown unequivocally histologically, other immunohistochemistry findings supported the diagnosis of hepatoid carcinoma combined with neuroendocrine carcinoma.
  • This report describes why hepatoid carcinoma should be considered as a differential diagnosis of a pancreatic mass, especially when serum AFP is elevated.

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  • (PMID = 20479919.001).
  • [ISSN] 2005-1212
  • [Journal-full-title] Gut and liver
  • [ISO-abbreviation] Gut Liver
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2871600
  • [Keywords] NOTNLM ; Hepatoid carcinoma / Neuroendocrine carcinoma / Pancreas
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12. Jamieson NB, Glen P, McMillan DC, McKay CJ, Foulis AK, Carter R, Imrie CW: Systemic inflammatory response predicts outcome in patients undergoing resection for ductal adenocarcinoma head of pancreas. Br J Cancer; 2005 Jan 17;92(1):21-3
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  • [Title] Systemic inflammatory response predicts outcome in patients undergoing resection for ductal adenocarcinoma head of pancreas.
  • The aim of the present study was to examine the relationship between the clinicopathological status, the pre- and postoperative systemic inflammatory response and survival in patients undergoing potentially curative resection for ductal adenocarcinoma of the head of the pancreas.
  • Patients (n = 65) who underwent resection of ductal adenocarcinoma of the head of pancreas between 1993 and 2001, and had pre- and postoperative measurements of C-reactive protein, were included in the study.
  • The majority of patients had stage III disease (International Union Against Cancer Criteria, IUCC), positive circumferential margin involvement (R1), tumour size greater than 25 mm with perineural and lymph node invasion and died within the follow-up period.
  • The results of the present study indicate that, in patients who have undergone potentially curative resection for ductal adenocarcinoma of the head of pancreas, the presence of a systemic inflammatory response predicts poor outcome.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / immunology. Inflammation / complications. Pancreatic Neoplasms / immunology

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  • (PMID = 15597096.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 9007-41-4 / C-Reactive Protein
  • [Other-IDs] NLM/ PMC2361749
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13. Caricato M, Borzomati D, Ausania F, Garberini A, Rabitti C, Tonini G, Coppola R: Cerebellar metastasis from pancreatic adenocarcinoma. A case report. Pancreatology; 2006;6(4):306-8
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  • [Title] Cerebellar metastasis from pancreatic adenocarcinoma. A case report.
  • The first discovery of a cerebellar metastasis of pancreatic carcinoma in a living patient is described.
  • Two years earlier the patient had undergone a pancreaticoduodenectomy for an adenocarcinoma of the head of the pancreas with a lymph node metastasis.
  • Clinical evaluation revealed an intracranial tumor without signs of pancreatic recurrence.
  • [MeSH-major] Adenocarcinoma / secondary. Cerebellar Neoplasms / radiography. Cerebellar Neoplasms / secondary. Pancreatic Neoplasms / pathology

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  • [Copyright] Copyright (c) 2006 S. Karger AG, Basel and IAP.
  • (PMID = 16636605.001).
  • [ISSN] 1424-3903
  • [Journal-full-title] Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
  • [ISO-abbreviation] Pancreatology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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14. Nakagohri T, Kinoshita T, Konishi M, Takahashi S, Gotohda N, Kobayashi S, Kojima M, Miyauchi H, Asano T: Inferior head resection of the pancreas for intraductal papillary mucinous neoplasms. J Hepatobiliary Pancreat Sci; 2010 Nov;17(6):798-802
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  • [Title] Inferior head resection of the pancreas for intraductal papillary mucinous neoplasms.
  • Thus, a variety of types of partial pancreatic resections have been advocated for treating these low-grade malignant tumors.
  • METHODS: We performed a retrospective review of the clinicopathologic features and surgical outcome in 15 patients who underwent inferior head resection for IPMN at the Chiba University Hospital and National Cancer Center Hospital East between July 1994 and January 2007.
  • Subsequent pancreatoduodenectomy was performed in one patient because of noninvasive carcinoma with multiple mucous lakes in the pancreatic parenchyma.
  • Pancreatic fistula occurred in 7 (47%) patients.
  • Two patients died of pancreatic ductal adenocarcinoma, 30 and 78 months after inferior head resection.
  • CONCLUSIONS: Pancreatic endocrine and exocrine function was well preserved after inferior head resection.
  • Pancreatic fistula occurred more frequently after inferior head resection than with conventional pancreatoduodenectomy.
  • [MeSH-major] Adenocarcinoma, Mucinous / surgery. Carcinoma, Pancreatic Ductal / surgery. Carcinoma, Papillary / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Retrospective Studies. Treatment Outcome

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  • (PMID = 19727540.001).
  • [ISSN] 1868-6982
  • [Journal-full-title] Journal of hepato-biliary-pancreatic sciences
  • [ISO-abbreviation] J Hepatobiliary Pancreat Sci
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] Japan
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15. Hav M, Lem D, Chhut SV, Kong R, Pauwels P, Cuvelier C, Piet P: Clear-cell variant of solid-pseudopapillary neoplasm of the pancreas: a case report and review of the literature. Malays J Pathol; 2009 Dec;31(2):137-41
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  • [Title] Clear-cell variant of solid-pseudopapillary neoplasm of the pancreas: a case report and review of the literature.
  • Solid-pseudopapillary neoplasm (SPN) of the pancreas is a rare neoplasm reported to have a favourable prognosis because of its slow-growing behaviour.
  • Its clear cell variant creates challenges in distinction from other clear cell tumours in the pancreas.
  • Exploratory laparotomy revealed a 5.2 cm well-demarcated tumour in the head of the pancreas, which was treated with Whipple procedure.
  • Difficulties are recognized in differentiating clear-cell SPN from "sugar" tumours, metastatic renal cell carcinoma, clear-cell variant of pancreatic endocrine neoplasm and ductal adenocarcinoma.
  • When facing such difficulties, nuclear and cytoplamic beta-catenin, nuclear E-cadherin expressions and absence of membranous E-cadherin staining are useful in differentiating clear-cell SPN from other clear cell tumours in the pancreas.
  • [MeSH-major] Carcinoma, Papillary / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Carcinoma, Islet Cell / diagnosis. Carcinoma, Pancreatic Ductal / diagnosis. Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / secondary. Cell Nucleus / chemistry. Cell Nucleus / pathology. Cytoplasm / chemistry. Cytoplasm / pathology. Diagnosis, Differential. Female. Humans. Perivascular Epithelioid Cell Neoplasms / diagnosis


16. Moral A, Muñoz-Guijosa C, González JA, Magarzo J, Hernández A, Artigas V, Trias M: [Intraductal papillary mucinous neoplasms of the pancreas]. Cir Esp; 2005 May;77(5):258-62
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  • [Title] [Intraductal papillary mucinous neoplasms of the pancreas].
  • INTRODUCTION: Mucin-producing pancreatic tumors account for 1% of all malignant tumors of the pancreas.
  • Notable among these are intraductal papillary mucinous neoplasms of the pancreas, due to their variable clinical behavior, increased frequency, and the controversy surrounding the most suitable treatment and diagnostic methods.
  • PATIENTS AND METHOD: We performed a prospective review of patients with a diagnosis of intraductal papillary mucinous neoplasm of the pancreas between 1996 and 2001.
  • The most frequent localization was the pancreatic head.
  • Seven patients underwent pancreatic resection and only one patient was not surgically treated.
  • CONCLUSION: Intraductal papillary mucinous neoplasms of the pancreas generally appear in the sixth decade of life.
  • These neoplasms typically occur in the head of the pancreas.
  • [MeSH-major] Adenocarcinoma, Mucinous. Carcinoma, Papillary. Pancreatic Neoplasms

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  • (PMID = 16420930.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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17. Sasaki E, Tsunoda N, Hatanaka Y, Mori N, Iwata H, Yatabe Y: Breast-specific expression of MGB1/mammaglobin: an examination of 480 tumors from various organs and clinicopathological analysis of MGB1-positive breast cancers. Mod Pathol; 2007 Feb;20(2):208-14
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  • Previously, we used the reverse transcription-polymerase chain reaction (RT-PCR) to show that mammaglobin (MGB1) can serve as a differential marker of breast cancer metastasis from primary lung cancer.
  • Of the other cancers examined, including 29 of the head and neck, eight of the thyroid, 106 of the lung, 35 of the gastrointestinal tract, three of the pancreas, 14 of the uterine cervix and 13 of the ovary, none were positive for MGB1 except a proportion of salivary gland tumors (6/11, 55%) and endometrial cancers (3/23, 13%).
  • In terms of practical diagnosis, MGB1 immunohistochemistry can serve as a differential marker of breast cancer metastasis from primary lung cancer for two reasons.
  • Firstly, HER2-positive breast cancer frequently lacks estrogen receptor expression, but MGB1 is expressed in about half of this subtype.
  • [MeSH-major] Adenocarcinoma / metabolism. Breast Neoplasms / metabolism. Neoplasm Proteins / metabolism. Uteroglobin / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Cell Count. Diagnosis, Differential. Disease-Free Survival. Female. Humans. Immunoenzyme Techniques. Japan / epidemiology. Lung Neoplasms / diagnosis. Lung Neoplasms / metabolism. Lung Neoplasms / secondary. Mammaglobin A. Neoplasm Staging. Receptors, Estrogen / metabolism. Survival Rate. Tissue Array Analysis

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  • (PMID = 17192791.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mammaglobin A; 0 / Neoplasm Proteins; 0 / Receptors, Estrogen; 0 / SCGB2A2 protein, human; 9060-09-7 / Uteroglobin
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18. Zacharias T, Jaeck D, Oussoultzoglou E, Neuville A, Bachellier P: Impact of lymph node involvement on long-term survival after R0 pancreaticoduodenectomy for ductal adenocarcinoma of the pancreas. J Gastrointest Surg; 2007 Mar;11(3):350-6
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  • [Title] Impact of lymph node involvement on long-term survival after R0 pancreaticoduodenectomy for ductal adenocarcinoma of the pancreas.
  • Pancreaticoduodenectomy remains the only potentially curative treatment for adenocarcinoma of the pancreas.
  • The aim of this study was to analyze prognostic factors impacting survival after R0 pancreaticoduodenectomy for adenocarcinoma in the head of the pancreas.
  • Between 1995 and 2002, a potentially curative (R0) pancreaticoduodenectomy with pancreatogastrostomy for ductal adenocarcinoma in the head of the pancreas was performed in 81 patients (42 women and 39 men) with a mean age of 64 years (range 35-84).
  • The main risk factor associated with poor survival after an R0 pancreaticoduodenectomy for adenocarcinoma in the head of pancreas was lymph node status: The presence of two or more positive lymph nodes was associated with decreased survival.
  • [MeSH-major] Adenocarcinoma / surgery. Carcinoma, Pancreatic Ductal / surgery. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy

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  • (PMID = 17458610.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Murakami Y, Uemura K, Ohge H, Hayashidani Y, Sudo T, Sueda T: Intraductal papillary-mucinous neoplasms and mucinous cystic neoplasms of the pancreas differentiated by ovarian-type stroma. Surgery; 2006 Sep;140(3):448-53
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  • [Title] Intraductal papillary-mucinous neoplasms and mucinous cystic neoplasms of the pancreas differentiated by ovarian-type stroma.
  • BACKGROUND: Intraductal papillary-mucinous neoplasms (IPMN) and mucinous cystic neoplasms (MCN) of the pancreas have similar clinicopathologic findings.
  • METHODS: Medical records for 77 patients with pancreatic cystic neoplasms with mucin secretion were reviewed.
  • RESULTS: IPMNs consisted of 32 adenomas, 12 borderline neoplasms, 13 adenocarcinomas in situ, and 13 invasive adenocarcinomas; MCNs included 6 adenomas and 1 invasive adenocarcinoma.
  • The location of the pancreatic mass differed, with 76% 0f IPMNs occurring in the head, while 86% of MCNs occurred in the body or tail.
  • Mass mean size was significantly smaller (28 mm vs 78 mm, P < .001), and mean diameter of the main pancreatic duct was larger (6.8 mm vs 3.1 mm, P < .001) in IPMN than in MCN.
  • Communication between the cyst and main pancreatic duct was more frequent in IPMNs (67/70) than in MCNs (1/7).
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma, Mucinous / pathology. Adenoma / pathology. Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Papillary / pathology. Stromal Cells / pathology
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Disease Progression. Female. Humans. Male. Middle Aged. Ovary / cytology. Prognosis. Retrospective Studies. Survival Rate

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  • [CommentIn] Surgery. 2007 Apr;141(4):545-6 [17383536.001]
  • (PMID = 16934608.001).
  • [ISSN] 0039-6060
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Sugimoto K, Okada K, Nakahira S, Okamura S, Miki H, Nakata K, Suzuki R, Yoshimura M, Uji K, Yoshida A, Tamura S: [A case of metastatic pancreatic cancer after combination chemotherapy with uracil-tegafur and gemcitabine]. Gan To Kagaku Ryoho; 2009 Feb;36(2):321-3
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  • [Title] [A case of metastatic pancreatic cancer after combination chemotherapy with uracil-tegafur and gemcitabine].
  • We report a case of pancreas head cancer with liver metastasis treated with uracil-tegafur (UFT) and gemcitabine combined chemotherapy.
  • The histopathological diagnosis was adenocarcinoma, so we inserted a self-expandable metallic stent (EMS) in this inoperable pancreas head cancer.
  • Renewed liver metastases did not appear, and the pancreas head tumor partially responded.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Deoxycytidine / analogs & derivatives. Pancreatic Neoplasms / drug therapy. Pancreatic Neoplasms / pathology. Tegafur / therapeutic use. Uracil / therapeutic use


21. Schnelldorfer T, Ware AL, Sarr MG, Smyrk TC, Zhang L, Qin R, Gullerud RE, Donohue JH, Nagorney DM, Farnell MB: Long-term survival after pancreatoduodenectomy for pancreatic adenocarcinoma: is cure possible? Ann Surg; 2008 Mar;247(3):456-62
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  • [Title] Long-term survival after pancreatoduodenectomy for pancreatic adenocarcinoma: is cure possible?
  • OBJECTIVE: To determine long-term survival after pancreatoduodenectomy for pancreatic ductal adenocarcinoma and to identify clinical factors associated with long-term survival.
  • SUMMARY BACKGROUND DATA: The prognosis for long-term survival even after potentially curative resection for pancreatic adenocarcinoma is thought to be poor.
  • Clinical factors determining short-term survival after pancreatic resection are well studied, but prognostic factors predicting long-term survival with a potential for cure are poorly understood.
  • METHODS: A case-control study was conducted of 357 patients who underwent pancreatoduodenectomy for pancreatic ductal adenocarcinoma between 1981 and 2001.
  • Histologic specimens were reanalyzed to confirm diagnosis.
  • Five-year survival was no guarantee of cure because 16% of this subset died of pancreatic cancer up to 7.8 years after operation.
  • CONCLUSION: Pancreatoduodenectomy for adenocarcinoma in the head of pancreas can provide long-term survival in a subset of patients, particularly in the absence of lymph node metastasis.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / surgery. Pancreatic Neoplasms / mortality. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy

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  • (PMID = 18376190.001).
  • [ISSN] 0003-4932
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Serum Albumin
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22. Calculli L, Pezzilli R, Brindisi C, Morabito R, Casadei R, Zompatori M: Pancreatic and extrapancreatic lesions in patients with intraductal papillary mucinous neoplasms of the pancreas: a single-centre experience. Radiol Med; 2010 Apr;115(3):442-52
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  • [Title] Pancreatic and extrapancreatic lesions in patients with intraductal papillary mucinous neoplasms of the pancreas: a single-centre experience.
  • RESULTS: Pancreatic IPMN was localised in the head in 43 patients (30.3%), in the body in 13 (9.2%), in the tail in ten (7.0%), in the head-body in 17 (12.0%), in the body-tail in 15 (10.6%) diffuse throughout the gland in 44 (31.0%).
  • Twenty patients (14.1%) had associated pancreatic or extrapancreatic diseases.
  • In evaluating the distribution of pancreatic or extrapancreatic diseases according to IPMN type, we found that this was not significantly different among types I, II and III (p=0.776).
  • CONCLUSIONS: The majority of pancreatic and extrapancreatic cancers occur before the diagnosis of IPMNs is made and is not related to the type of IPMN.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Papillary / pathology. Diagnostic Imaging. Neoplasms, Multiple Primary / pathology. Neoplasms, Second Primary / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 20082228.001).
  • [ISSN] 1826-6983
  • [Journal-full-title] La Radiologia medica
  • [ISO-abbreviation] Radiol Med
  • [Language] eng; ita
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Contrast Media
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23. Turculeanu A, Avrămescu C, Bălăşoiu M, Pleşea E, Simionescu C, Popescu CF: Immuno-histopathological correlations in exocrine pancreatic cancer. Rom J Morphol Embryol; 2005;46(2):137-44
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  • [Title] Immuno-histopathological correlations in exocrine pancreatic cancer.
  • OBJECTIVE: Study of CA19-9 antigen from the immunological point of view, at the patients with pancreatic cancer, and his relation with the histopathological aspects.
  • MATERIAL AND METHOD: The determinations have been done at the time of the diagnosis and after the treatment of the patients with pancreatic cancer (25).
  • RESULTS: The values of the CA19-9 marker have been increased at the time of the diagnosis either in pancreatic cancer of the head and mid.
  • At the moment of the diagnosis the CA19-9 marker has higher values (150-400 U/ml) in cancer of the pancreatic body than in cancer of the head of the pancreas (40-200 U/ml).
  • Correlating the size of the tumor with the value of the CA19-9 marker in the case of pancreatic cancer we have been shown the highest serum values (300-400 U/ml) at patients whose tumor was 3 cm bigger.
  • The highest values of the CA 19-9 marker were found in cases of mid pancreas adenocarcinoma.
  • CONCLUSION: CA19-9 marker values higher than normal cause problems to digestive cancer (especially pancreatic).
  • The high values of CA 19-9 suggest an adenocarcinoma.
  • [MeSH-major] CA-19-9 Antigen / analysis. Pancreatic Neoplasms / immunology. Pancreatic Neoplasms / pathology

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  • (PMID = 16287000.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen
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24. Pickartz T, Mayerle J, Kraft M, Evert M, Evert K, Kühn JP, Heidecke CD, Lerch MM: [Chronic pancreatitis as a risk factor for the development of pancreatic cancer--diagnostic challenges]. Med Klin (Munich); 2010 Apr;105(4):281-5
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  • [Title] [Chronic pancreatitis as a risk factor for the development of pancreatic cancer--diagnostic challenges].
  • Patients with chronic pancreatitis are burdened with an increased risk of developing pancreatic cancer.
  • Strategies or guidelines for the surveillance and early detection of pancreatic adenocarcinoma in patients with chronic pancreatitis are not established, because available clinical, serologic or imaging techniques are still of limited sensitivity and specificity.
  • Despite these limitations do patients with chronic pancreatitis and suspected pancreatic cancer need a careful and sometimes repeated diagnostic work-up.
  • A clear benefit of surveillance programs outside of clinical trials for the early detection of pancreatic cancer has not been demonstrated.
  • A 51-year-old patient with chronic pancreatitis is reported who developed cancer of the pancreatic head while undergoing repeated imaging studies.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / diagnosis. Pancreatic Neoplasms / diagnosis. Pancreatitis, Alcoholic / diagnosis
  • [MeSH-minor] Anastomosis, Roux-en-Y. Disease Progression. Early Diagnosis. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Pancreas / pathology. Pancreatectomy. Tomography, X-Ray Computed. Ultrasonography

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  • (PMID = 20455050.001).
  • [ISSN] 1615-6722
  • [Journal-full-title] Medizinische Klinik (Munich, Germany : 1983)
  • [ISO-abbreviation] Med. Klin. (Munich)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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25. De Filippo M, Bocchi C, Quartieri L, Corradi D, Zompatori M: Mangafodipir-DPDP enhanced MRI visualization of a pancreatic adenocarcinoma previously undetected by extracellular contrast enhanced CT and MRI. Acta Biomed; 2007 Dec;78(3):225-8
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  • [Title] Mangafodipir-DPDP enhanced MRI visualization of a pancreatic adenocarcinoma previously undetected by extracellular contrast enhanced CT and MRI.
  • We report a case of adenocarcinoma of the head of the pancreas, occult at extracellular contrast enhanced MDCT and magnetic resonance imaging (MRI), which was detected by MRI only with the use of a tissue-specific contrast agent (Mangafodipir trisodium Mn- DPDP).
  • The histological examination after duodenopancreatectomy confirmed the diagnosis.
  • Contrast-enhanced multi-detector computed tomography (MDCT) is currently considered to be the reference method for diagnosing and staging of pancreatic adenocarcinoma.
  • The technological evolution of magnetic resonance imaging and the development of organ-specific contrast media for liver and pancreas have led to a progressively more extensive use of this method for the investigation of suspected lesions.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / radiography. Contrast Media. Edetic Acid / analogs & derivatives. Magnetic Resonance Imaging / methods. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / radiography. Pyridoxal Phosphate / analogs & derivatives. Tomography, X-Ray Computed
  • [MeSH-minor] Cholangiopancreatography, Endoscopic Retrograde. Female. Humans. Middle Aged. Pancreas / pathology. Pancreaticoduodenectomy

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  • (PMID = 18330084.001).
  • [ISSN] 0392-4203
  • [Journal-full-title] Acta bio-medica : Atenei Parmensis
  • [ISO-abbreviation] Acta Biomed
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Contrast Media; 5V5IOJ8338 / Pyridoxal Phosphate; 9G34HU7RV0 / Edetic Acid; P28BIW0UTB / N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid
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26. Carter RR, Woodall CE 3rd, McNally ME, Talboy GE, Lankachandra KM, Van Way CW 3rd: Mixed ductal-endocrine carcinoma of the pancreas with synchronous papillary carcinoma-in-situ of the common bile duct: a case report and literature review--synchronous pancreatic and bile duct tumors. Am Surg; 2008 Apr;74(4):338-40
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  • [Title] Mixed ductal-endocrine carcinoma of the pancreas with synchronous papillary carcinoma-in-situ of the common bile duct: a case report and literature review--synchronous pancreatic and bile duct tumors.
  • This report is a case of a 58-year-old woman with a mixed ductal-endocrine carcinoma of the pancreas and a synchronous carcinoma-in-situ of the common bile duct.
  • Biopsies from this lesion showed adenocarcinoma.
  • Subsequently, pancreatoduodenectomy was performed for the diagnosis of peri-ampullary carcinoma.
  • Gross examination revealed a 2-cm irregular, ulcerated lesion obstructing the distal 0.5 cm of the common bile duct within the head of the pancreas.
  • On histopathological examination, it was discovered that this lesion contained two separate neoplasms: papillary carcinoma-in-situ of the intraparenchymal portion of the common bile duct and a mixed ductal-endocrine carcinoma of the pancreas.
  • Mixed ductal-endocrine carcinoma of the pancreas is very rare.
  • [MeSH-major] Carcinoma in Situ / pathology. Carcinoma, Pancreatic Ductal / pathology. Common Bile Duct Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Pancreatic Neoplasms / pathology


27. Huo Z, Yang D, Chang XY, Wan JW, Chen J: [Intraductal papillary mucinous neoplasm of pancreas: a clinicopathologic and immunohistochemical study of 19 cases]. Zhonghua Bing Li Xue Za Zhi; 2008 Oct;37(10):670-5
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  • [Title] [Intraductal papillary mucinous neoplasm of pancreas: a clinicopathologic and immunohistochemical study of 19 cases].
  • OBJECTIVE: To study the clinicopathologic features and diagnosis of intraductal papillary mucinous neoplasm (IPMN) of the pancreas.
  • It affected patients in older age group (mean age = 59) and was located mainly in the head of pancreas (60%).
  • Histologically, the tumor consisted of papillary proliferations protruding into and expanding the pancreatic ducts.
  • Invasion into the surrounding pancreatic parenchyma was noted in 12 cases and chronic pancreatitis was present in 16 cases.
  • The prognosis after surgical resection however is better than that of conventional pancreatic adenocarcinoma.
  • Early recognition by radiologic examination (including ERCP) and pancreatic cytology would be helpful in early diagnosis.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Papillary / pathology. Immunohistochemistry / trends. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adaptor Proteins, Signal Transducing / analysis. Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / metabolism. Adult. Aged. Cell Cycle Proteins / analysis. Cholangiopancreatography, Endoscopic Retrograde. Female. Humans. Ki-67 Antigen / analysis. Male. Middle Aged. Pancreas / metabolism. Pancreas / pathology. Pancreatectomy. Pancreatic Ducts / metabolism. Pancreatic Ducts / pathology. Prognosis. Receptor, ErbB-2 / analysis. Treatment Outcome


28. Koizumi K, Fujii T, Matsumoto A, Sugiyama R, Suzuki S, Sukegawa R, Ozawa K, Orii F, Taruishi M, Saitoh Y, Sotokawa M, Takada A: [Synchronous double invasive ductal carcinomas of the pancreas with multifocal branch duct intraductal papillary mucinous neoplasms of the pancreas]. Nihon Shokakibyo Gakkai Zasshi; 2009 Jan;106(1):98-105
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  • [Title] [Synchronous double invasive ductal carcinomas of the pancreas with multifocal branch duct intraductal papillary mucinous neoplasms of the pancreas].
  • A 52-year-old man with a history of distal gastrectomy for gastric cancer was admitted to our hospital because of jaundice.
  • CT scan revealed double tumors in the pancreatic head and body concomitant with multicystic lesions of the pancreas.
  • Final histological diagnosis was double invasive ductal carcinomas of the pancreas head and tail with multifocal branch duct intraductal papillary mucinous adenomas of the pancreas.
  • The present case suggests that entire pancreas might have malignant potential in patients with intraductal papillary mucinous neoplasms.
  • [MeSH-major] Adenocarcinoma, Mucinous / surgery. Carcinoma, Pancreatic Ductal / surgery. Carcinoma, Papillary / surgery. Neoplasms, Multiple Primary. Pancreatic Neoplasms / surgery

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  • (PMID = 19122428.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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29. Sata N, Koizumi M, Tsukahara M, Yoshizawa K, Kurihara K, Nagai H: Single-branch resection of the pancreas. J Hepatobiliary Pancreat Surg; 2005;12(1):71-5
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  • [Title] Single-branch resection of the pancreas.
  • The treatment of intraductal papillary mucinous tumors (IPMT) of the pancreas is still controversial.
  • In this report we describe a single-branch resection of the pancreas (SBRP), which is a new method for the removal of branch-type IPMT of the head of the pancreas.
  • A multilobular cystic lesion (50 x 40 mm) in the head of the pancreas was incidentally detected in an asymptomatic 40-year-old man who underwent a routine ultrasound examination.
  • The tumor was carefully removed along the border of the cyst and the normal parenchyma, with complete preservation of the main pancreatic duct and the common bile duct.
  • A pancreatic fistula developed during the postoperative period, but was well-controlled by endoscopic naso-pancreatic drainage.
  • SBRP is a technically feasible procedure and this operation represents a minimally invasive alternative to any other segmental resection of the pancreas.
  • [MeSH-major] Adenocarcinoma, Mucinous / surgery. Adenocarcinoma, Papillary / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Adult. Diagnosis, Differential. Diagnostic Imaging. Humans. Male

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  • (PMID = 15754104.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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30. Sultana A, Shore S, Raraty MG, Vinjamuri S, Evans JE, Smith CT, Lane S, Chauhan S, Bosonnet L, Garvey C, Sutton R, Neoptolemos JP, Ghaneh P: Randomised Phase I/II trial assessing the safety and efficacy of radiolabelled anti-carcinoembryonic antigen I(131) KAb201 antibodies given intra-arterially or intravenously in patients with unresectable pancreatic adenocarcinoma. BMC Cancer; 2009 Feb 25;9:66
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  • [Title] Randomised Phase I/II trial assessing the safety and efficacy of radiolabelled anti-carcinoembryonic antigen I(131) KAb201 antibodies given intra-arterially or intravenously in patients with unresectable pancreatic adenocarcinoma.
  • BACKGROUND: Advanced pancreatic cancer has a poor prognosis, and the current standard of care (gemcitabine based chemotherapy) provides a small survival advantage.
  • This study aimed to evaluate the safety and tolerability of KAb201, an anti-carcinoembryonic antigen monoclonal antibody, labelled with I(131) in pancreatic cancer (ISRCTN 16857581).
  • METHODS: Patients with histological/cytological proven inoperable adenocarcinoma of the head of pancreas were randomised to receive KAb 201 via either the intra-arterial or intravenous delivery route.
  • [MeSH-major] Adenocarcinoma / diagnostic imaging. Carcinoembryonic Antigen / administration & dosage. Immunotoxins / administration & dosage. Iodine Radioisotopes / administration & dosage. Pancreatic Neoplasms / radiotherapy. Radioimmunotherapy / methods

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  • (PMID = 19243606.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Databank-accession-numbers] ISRCTN/ ISRCTN16857581
  • [Grant] United Kingdom / Medical Research Council / / G9900432; United Kingdom / Cancer Research UK / /
  • [Publication-type] Clinical Trial, Phase I; Clinical Trial, Phase II; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Neoplasm; 0 / Carcinoembryonic Antigen; 0 / Immunotoxins; 0 / Iodine Radioisotopes
  • [Other-IDs] NLM/ PMC2656541
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31. Obuchi T, Sasaki A, Shimooki O, Minakawa Y, Abe T, Nitta H, Otsuka K, Koeda K, Ikeda K, Wakabayashi G: [Local recurrence after surgical resection of pancreatic cancer effectively treated with combined chemoradiotherapy]. Gan To Kagaku Ryoho; 2009 Jun;36(6):991-4
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  • [Title] [Local recurrence after surgical resection of pancreatic cancer effectively treated with combined chemoradiotherapy].
  • We report a patient for whom systemic chemotherapy using gemcitabine was effective against local recurrence of pancreatic cancer.
  • A 59-year-old man underwent pancreatoduodenectomy for pancreatic head cancer.
  • The diagnosis was moderately-differentiated tubular adenocarcinoma(tubular type, pT2, pN0, fM0, fStage II ).
  • Ten months after surgery, the patient had a CT examination which revealed a mass at the cut-end of the pancreas.
  • Twenty-one months after chemotherapy, CT examination revealed regrowth at the same location at the cut-end of the pancreas, and so radiotherapy was performed at a total 63 Gy.
  • [MeSH-major] Adenocarcinoma / therapy. Pancreatic Neoplasms / therapy

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  • (PMID = 19542722.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen; 0W860991D6 / Deoxycytidine; 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; B76N6SBZ8R / gemcitabine; 1-UFT protocol
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32. Inagaki M, Goto J, Tokusashi Y, Miyokawa N, Yokoyama K, Ikeue S, Kasai S: Multifocal pancreatic intraepithelial neoplasia (PanIN) lesions of the branch ducts associated with lobular parenchymal atrophy in a Japanese patient diagnosed to have familial pancreatic cancer. Clin J Gastroenterol; 2009 Apr;2(2):103-108
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  • [Title] Multifocal pancreatic intraepithelial neoplasia (PanIN) lesions of the branch ducts associated with lobular parenchymal atrophy in a Japanese patient diagnosed to have familial pancreatic cancer.
  • This report presents a case of Japanese familial pancreatic cancer (FPC) with multifocal pancreatic intraepithelial neoplasia (PanIN) lesions of the branch ducts probably associated with lobular parenchymal atrophy.
  • The risk of pancreatic cancer is significantly increased in those associated with FPC, and this risk increases with increasing numbers of affected first-degree relatives, but there have been four Japanese cases reported.
  • A 63-year-old Japanese male was referred to the hospital for evaluation and treatment of a pancreatic head tumor.
  • His family history included pancreatic cancer in two-first-degree relatives and three-second-degree relatives.
  • The histological findings of the main tumor showed a moderately differentiated tubular adenocarcinoma in the head of the pancreas without metastasis of the resected lymph nodes.

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  • [ISSN] 1865-7257
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  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
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  • [Keywords] NOTNLM ; Familial pancreatic cancer / Lobular parenchymal atrophy / PanIN / Pancreatoduodenectomy
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33. Grenacher L, Klauss M: [Computed tomography of pancreatic tumors]. Radiologe; 2009 Feb;49(2):107-23
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  • [Title] [Computed tomography of pancreatic tumors].
  • Computed tomography (CT) and in particular multi-detector row computed tomography (MDCT), also known as multislice CT (MSCT), is ideally suited for detecting pancreatic tumors because of the high spatial resolution.The method of choice is hydro-CT which involves distension of the stomach and duodenum by administration of 1-1.5 l water as a negative contrast medium under medically induced hypotension by administration of buscopan.
  • The patient is laid on the right side at an angle of 30-45 degrees in order to obtain an artefact-free image of the close anatomical relationship around the pancreas head.
  • After the correct diagnosis of an adenocarcinoma has been made only 20% of all patients are shown to have a surgically resectable disease, but the overall survival rate is significantly higher after resection in combination with a multimodal tumor therapy strategy.
  • The reason is that the correct diagnosis of the resectability of the tumor is one of the main criteria for overall survival of these patients.
  • Currently practically all pancreatic tumors can be detected using MDCT and the detection rate varies between 70% and 100% (most recent literature references give a sensitivity of 89% and specificity up to 99%).
  • In some rare cases the differentiation between focal necrotizing pancreatitis and pancreatic carcinoma can be difficult even with sophisticated protocols.
  • MDCT is an ideal tool for the detection of neuroendocrine tumors, metastases and for the differentiation of cystic pancreatic lesions such as pseudocysts, microcystic adenomas or intraductal papillary mucinous neoplasms (IPMN).
  • Particularly, the differentiation of the latter into benign, borderline or malignant transformation is not always possible, but indirect signs, such as small nodules adjacent to the ductal wall, the diameter of the pancreatic duct, or a direct communication between cystic lesions and duct can be detected because of the high spatial resolution and is comparable to the findings in MRI.
  • [MeSH-major] Image Processing, Computer-Assisted. Imaging, Three-Dimensional. Pancreatic Neoplasms / diagnostic imaging. Tomography, Spiral Computed
  • [MeSH-minor] Adenocarcinoma / diagnostic imaging. Adenocarcinoma / mortality. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adenocarcinoma, Mucinous / diagnostic imaging. Adenocarcinoma, Mucinous / mortality. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / surgery. Carcinoma, Pancreatic Ductal / diagnostic imaging. Carcinoma, Pancreatic Ductal / mortality. Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Pancreatic Ductal / surgery. Carcinoma, Papillary / diagnostic imaging. Carcinoma, Papillary / mortality. Carcinoma, Papillary / pathology. Carcinoma, Papillary / surgery. Diagnosis, Differential. Disease-Free Survival. Humans. Neuroendocrine Tumors / diagnostic imaging. Neuroendocrine Tumors / mortality. Neuroendocrine Tumors / pathology. Neuroendocrine Tumors / surgery. Pancreas / diagnostic imaging. Pancreas / pathology. Pancreatectomy. Pancreatic Pseudocyst / diagnostic imaging. Prognosis. Sensitivity and Specificity

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  • (PMID = 19137277.001).
  • [ISSN] 1432-2102
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 71
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34. Minchom A, Chan S, Melia W, Shah R: An unusual case of pancreatic cancer with leptomeningeal infiltration. J Gastrointest Cancer; 2010 Jun;41(2):107-9
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  • [Title] An unusual case of pancreatic cancer with leptomeningeal infiltration.
  • INTRODUCTION: Pancreatic cancer is a common malignancy and often presents at an advanced stage.
  • We aim to describe an unusual case of leptomeningeal involvement from pancreatic cancer.
  • CT scan of the abdomen showed subtle narrowing of the common bile duct and pancreatic ducts.
  • Endoscopic ultrasound showed a 5-cm lesion in the head of the pancreas with adenocarcinoma cells on fine needle aspiration.
  • DISCUSSION: This case represents the unusual presentation of advanced leptomeningeal carcinomatosis in a locally early stage pancreatic adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Meningeal Carcinomatosis / secondary. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / pathology

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35. Schima W, Ba-Ssalamah A, Kölblinger C, Kulinna-Cosentini C, Puespoek A, Götzinger P: Pancreatic adenocarcinoma. Eur Radiol; 2007 Mar;17(3):638-49
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  • [Title] Pancreatic adenocarcinoma.
  • Adenocarcinoma is the most common malignant pancreatic tumor, affecting the head of the pancreas in 60-70% of cases.
  • By the time of diagnosis, at least 80% of tumors are unresectable.
  • Helical computed tomography (CT) is very effective in detecting and staging adenocarcinoma, with a sensitivity of up to 90% for detection and an accuracy of 80-90% for staging, but it has limitations in detecting small cancers.
  • MDCT has been found to be at least equivalent to contrast-enhanced magnetic resonance imaging (MRI) for detecting adenocarcinoma.
  • Mangafodipir-enhanced MRI reveals a very high tumor-pancreas contrast, which helps in diagnosing small cancers.
  • It is the technique of choice for image-guided biopsy if a histologic diagnosis is required for further therapy.
  • [MeSH-major] Adenocarcinoma / diagnosis. Pancreatic Neoplasms / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 17021700.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 65
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36. Liszka Ł, Pajak J, Zielińska-Pajak E, Gołka D, Mrowiec S, Lampe P: Different approaches to assessment of lymph nodes and surgical margin status in patients with ductal adenocarcinoma of the pancreas treated with pancreaticoduodenectomy. Pathology; 2010 Feb;42(2):138-46
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  • [Title] Different approaches to assessment of lymph nodes and surgical margin status in patients with ductal adenocarcinoma of the pancreas treated with pancreaticoduodenectomy.
  • AIM: To develop a method of gross examination of pancreaticoduodenectomy specimens with pancreatic ductal adenocarcinoma, allowing adequate assessment of the entire pancreatic surface as a surgical margin, which would not affect the lymph node yield.
  • (1) period 2006-2007, when the pancreatic surface (except for the transection margin and superior mesenteric artery margin) was not examined;.
  • (2) period January-September 2008, when the posterior pancreatic surface (posterior circumferential radial margin) was examined using an improved method based on sampling of 2.0-2.5 mm thick consecutive slices perpendicular to the duodenal axis; and (3) period October 2008 - June 2009, when the whole surface of the pancreatic head was sampled using the approach mentioned above.
  • CONCLUSIONS: The newly proposed approach allowed adequate assessment of the entire pancreatic head surface as a surgical margin and reduced the risk of under-detection of R1 status.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / secondary. Lymph Nodes / pathology. Pancreatic Neoplasms / pathology. Pancreaticoduodenectomy
  • [MeSH-minor] Aged. Female. Humans. Lymphatic Metastasis / diagnosis. Male. Middle Aged. Neoplasm, Residual. Retrospective Studies

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  • (PMID = 20085515.001).
  • [ISSN] 1465-3931
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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37. Rana SS, Bhasin DK, Jain K, Nada R, Sinha SK, Singh K: Endoscopic diagnosis of squamous cell carcinoma of the pancreas invading the stomach. JOP; 2009;10(2):181-3
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  • [Title] Endoscopic diagnosis of squamous cell carcinoma of the pancreas invading the stomach.
  • CONTEXT: Squamous cell carcinoma of the pancreas is an unusual tumor due to the absence of squamous cells in the normal pancreas.
  • Its clinical presentation is similar to that of adenocarcinoma of the pancreas and is usually diagnosed intraoperatively or at autopsy.
  • Contrast-enhanced computerized tomography revealed a heterogeneous enhancing mass in the head of pancreas and upper gastrointestinal endoscopy revealed an ulcerated polypoidal lesion in the stomach; the endoscopic biopsies taken from this region revealed infiltration of the lamina propria with malignant squamous cells.
  • CONCLUSION: A rare case of squamous cell carcinoma of the head of the pancreas presenting with obstructive jaundice and gastric outlet obstruction and in which diagnosis was established by endoscopic biopsies of the stomach has been described.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Pancreatic Neoplasms / diagnosis. Stomach / pathology
  • [MeSH-minor] Diagnosis, Differential. Endoscopy, Gastrointestinal. Humans. Male. Middle Aged


38. Arcari A, Anselmi E, Bernuzzi P, Bertè R, Lazzaro A, Moroni CF, Trabacchi E, Vallisa D, Vercelli A, Cavanna L: Primary pancreatic lymphoma. Report of five cases. Haematologica; 2005 Feb;90(2):ECR09
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  • [Title] Primary pancreatic lymphoma. Report of five cases.
  • Primary pancreatic lymphoma (PPL) is a very rare disease.
  • None of these patients had evidence of extrapancreatic disease and they were categorized as PPL involving pancreas only (stage IE, 3 patients) or pancreas and peripancreatic lymph nodes (stage IIE, 2 patients).
  • Imaging techniques showed a mass of the pancreatic head in all cases.
  • The histological diagnosis (3 diffuse-large cell non-Hodgkin's lymphoma and 2 lymphoplasmacytic lymphoma/immunocytoma) was made by ultrasound-guided fine needle aspiration biopsy and tissue core fine-needle biopsy in three patients and by surgery in the remaining two patients.
  • 1) imaging techniques can suggest the suspicion of PPL but are unable to distinguish PPL from pancreatic adenocarcinoma;.
  • 2) histological diagnosis can be easily obtained by percutaneous US-guided tissue core biopsy;.
  • 3) surgery can be avoided both for diagnosis and therapy but the treatment of choice of PPL may only be evaluated on a larger series of patients.
  • [MeSH-major] Lymphoma, Non-Hodgkin / diagnosis. Lymphoma, Non-Hodgkin / therapy. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / therapy

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  • (PMID = 15713583.001).
  • [ISSN] 1592-8721
  • [Journal-full-title] Haematologica
  • [ISO-abbreviation] Haematologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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39. Yang YM, Wan YL, Tian XD, Zhuang Y, Huang YT: Outcome of pancreaticoduodenectomy with extended retroperitoneal lymphadenectomy for adenocarcinoma of the head of the pancreas. Chin Med J (Engl); 2005 Nov 20;118(22):1863-9
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  • [Title] Outcome of pancreaticoduodenectomy with extended retroperitoneal lymphadenectomy for adenocarcinoma of the head of the pancreas.
  • BACKGROUND: Nowadays, there is a remarkable rise in resectability rate of periampullary adenocarcinoma and the mortality and morbidity of the pancreaticoduodenectomy procedure have been reduced remarkably, while the 5 year survival rates of patients with carcinoma of the head of the pancreas are still below 25%.
  • We conducted this retrospective study to evaluate the clinical outcome of radical pancreaticoduodenectomy with extended retroperitoneal lymphadenectomy as a surgical therapy for adenocarcinoma of the head of the pancreas.
  • METHODS: Twenty cases with adenocarcinoma of the head of the pancreas were treated by standard pancreaticoduodenectomy (removing only the peripancreatic lymph nodes en bloc with the tumour) from 1994 to 1997, and 46 cases with the same disease underwent extended retroperitoneal lymphadenectomy associated with standard pancreaticoduodenectomy from 1998 to 2002.
  • Of the 46 cases in the radical group, 26% (12/46) had metastatic adenocarcinoma in the resected retroperitoneal lymph nodes.
  • [MeSH-major] Adenocarcinoma / surgery. Lymph Node Excision. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy

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  • (PMID = 16313840.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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40. Fabregat J, Busquets J, Peláez N, Jorba R, García-Borobia F, Masuet C, Valls C, Ruiz-Osuna S, Serrano T, Galán M, Cambray M, Laquente B, Ramos E, Rafecas A: [Surgical treatment of pancreatic adenocarcinoma using cephalic duodenopancreatectomy (Part 2). Long term follow up after 204 cases]. Cir Esp; 2010 Dec;88(6):374-82
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  • [Title] [Surgical treatment of pancreatic adenocarcinoma using cephalic duodenopancreatectomy (Part 2). Long term follow up after 204 cases].
  • [Transliterated title] Tratamiento quirúrgico del adenocarcinoma pancreático mediante duodenopancreatectomía cefálica (parte 2). Seguimiento a largo plazo tras 204 casos.
  • INTRODUCTION: Surgery is the accepted treatment in adenocarcinoma of the head of the pancreas; however, the long-term survival continues to be low.
  • The aim of this study is to define prognostic factors of long-term survival after cephalic duodenopancreatectomy due to pancreatic adenocarcinoma.
  • MATERIAL AND METHODS: We have collected data on the treatment of adenocarcinoma of the head of the pancreas (ADHP) by means of a cephalic duodenopancreatectomy (CDP) performed n the Bellvitge University Hospital (Barcelona) from 1991 to 2007.
  • CONCLUSIONS: Surgery of head of the pancreas adenocarcinoma must include an adequate lymphadectomy, and must be performed with a low morbidity and without the need of a peri-operative transfusion.
  • [MeSH-major] Adenocarcinoma / surgery. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy

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  • [Copyright] Copyright © 2010 AEC. Published by Elsevier Espana. All rights reserved.
  • [CommentIn] Cir Esp. 2011 Jun-Jul;89(6):411; author reply 412 [21550599.001]
  • (PMID = 21030012.001).
  • [ISSN] 1578-147X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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41. Ellsmere J, Mortele K, Sahani D, Maher M, Cantisani V, Wells W, Brooks D, Rattner D: Does multidetector-row CT eliminate the role of diagnostic laparoscopy in assessing the resectability of pancreatic head adenocarcinoma? Surg Endosc; 2005 Mar;19(3):369-73
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  • [Title] Does multidetector-row CT eliminate the role of diagnostic laparoscopy in assessing the resectability of pancreatic head adenocarcinoma?
  • BACKGROUND: We hypothesized that the high-quality images from multidetector-row computed tomography (MDCT) would lead to improved sensitivity and specificity for predicting resectable pancreatic head adenocarcinoma, thus diminishing the value of staging laparoscopy.
  • CONCLUSIONS: Despite the improvements in image quality obtained with multidetector-row technology, CT imaging remains a relatively nonspecific test for predicting resectability in patients with adenocarcinoma of the head of the pancreas.
  • Minimally invasive modalities with higher specificity, particularly laparoscopy, continue to have an important role in staging pancreatic head adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Laparoscopy. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / surgery. Tomography, X-Ray Computed

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  • (PMID = 15624058.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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42. Ohmura T, Umekita N, Ohkubo T, Tanaka S, Maeshiro T, Matsuo S, Miyamoto S, Inoue S, Kitamura M: [Local recurrence of pancreatic cancer successfully treated with gemcitabine]. Gan To Kagaku Ryoho; 2005 Feb;32(2):239-41
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  • [Title] [Local recurrence of pancreatic cancer successfully treated with gemcitabine].
  • We report a patient for whom systemic chemotherapy using gemcitabine was effective against local recurrence of pancreatic cancer.
  • A 58-year-old man underwent pancreatoduodenectomy for a pancreatic head cancer.
  • The diagnosis was Stage IVb poorly-differentiated tubular adenocarcinoma, scirrhous type, pT4, PL (+), P0, H0, pN2.
  • Gastroscopy and CT examination revealed a mass at the cut-end of the pancreas invading the stomach.
  • The recurrent tumor in the stomach disappeared, and the mass at the cut-end of the pancreas became small.
  • Two years after the diagnosis of recurrence, he returned to work, and his chemotherapy is being continued as an outpatient.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antimetabolites, Antineoplastic / therapeutic use. Deoxycytidine / analogs & derivatives. Deoxycytidine / therapeutic use. Neoplasm Recurrence, Local / drug therapy. Pancreatic Neoplasms / drug therapy. Stomach Neoplasms / drug therapy

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  • (PMID = 15751641.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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43. Lin HL, Kuo LC, Chen CW, Lin YK, Lee WC: Pancreatic tail cancer with sole manifestation of left flank pain: a very rare presentation. Kaohsiung J Med Sci; 2008 Jun;24(6):324-7
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  • [Title] Pancreatic tail cancer with sole manifestation of left flank pain: a very rare presentation.
  • Pancreatic cancer is sometimes called a "silent disease" because it often causes no symptoms in the early stage.
  • The symptoms can be quite vague and various depending on the location of cancer in the pancreas.
  • The anatomic site distribution is 78% in the head of the pancreas, 11% in the body, and 11% in the tail.
  • Pancreatic cancer is rarely detected in the early stage, and it is very uncommon to diagnose pancreatic tail cancer during an emergency department visit.
  • The manifestation of pancreatic tail cancer as left flank pain is very rare and has seldom been identified in the literature.
  • We present a case of pancreatic tail cancer with the sole manifestation of dull left flank pain.
  • Radiographic evaluation with computed tomography was performed, and pancreatic tail tumor with multiple metastases was found unexpectedly.
  • We review the literature and discuss this rare presentation of pancreatic tail cancer.
  • [MeSH-major] Flank Pain / diagnosis. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Fatal Outcome. Female. Humans. Liver Neoplasms / pathology. Liver Neoplasms / secondary. Medical Oncology / methods. Middle Aged. Neoplasm Metastasis. Prognosis. Tomography, X-Ray Computed

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  • (PMID = 18635419.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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44. Saif MW: Primary pancreatic lymphomas. JOP; 2006;7(3):262-73
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  • [Title] Primary pancreatic lymphomas.
  • Primary pancreatic lymphomas are extremely rare.
  • Clinically, primary pancreatic lymphomas usually present with symptoms of carcinoma of the pancreatic head.
  • Patients with primary pancreatic lymphomas are between 35 and 75 years of age and with a strong male predominance.
  • An accurate cytopathologic diagnosis by fine-needle aspiration (FNA) is imperative because the primary treatment is non-surgical.
  • FNA coupled with flow cytometry analysis appears to be highly accurate in the diagnosis of primary pancreatic lymphomas.
  • Fluorescence in-situ hybridisation technique has been established its role in the diagnosis of lymphoid malignancies, including primary pancreatic lymphomas.
  • The differential diagnoses of primary pancreatic lymphomas include secondary lymphoma, pancreatic endocrine neoplasm, and florid chronic pancreatitis.
  • Primary pancreatic lymphomas has a much better prognosis than adenocarcinoma of the pancreas.
  • [MeSH-major] Lymphoma / diagnosis. Pancreatic Neoplasms / diagnosis

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  • (PMID = 16685107.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 40
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45. Wang H, Wieczorek RL, Zenilman ME, Desoto-Lapaix F, Ghosh BC, Bowne WB: Castleman's disease in the head of the pancreas: report of a rare clinical entity and current perspective on diagnosis, treatment, and outcome. World J Surg Oncol; 2007;5:133
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  • [Title] Castleman's disease in the head of the pancreas: report of a rare clinical entity and current perspective on diagnosis, treatment, and outcome.
  • BACKGROUND: Castleman's disease of the pancreas is a very rare condition that may resemble more common disease entities as well as pancreatic cancer.
  • CASE PRESENTATION: Here we report the case of a 58-year-old African American male with an incidentally discovered lesion in the head of the pancreas.
  • CONCLUSION: To date, eight cases of Castleman's disease associated with the pancreas have been described in the world literature.
  • We report the first case of unicentric disease situated within the head of the pancreas.
  • In addition, we discuss the diagnostic dilemma Castleman's disease may present to the pancreatic surgeon and review current data on pathogenesis, treatment, and outcome.
  • [MeSH-major] Giant Lymph Node Hyperplasia / pathology. Pancreatic Diseases / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Diagnosis, Differential. Humans. Male. Middle Aged. Pancreatic Neoplasms / pathology. Pancreaticoduodenectomy. Tomography, X-Ray Computed

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  • (PMID = 18028547.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 47
  • [Other-IDs] NLM/ PMC2206042
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46. Price L, Kozarek R, Agoff N: Squamous cell carcinoma arising within a choledochal cyst. Dig Dis Sci; 2008 Oct;53(10):2822-5
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  • Most commonly reported malignancies include cholangiocarcinoma, adenocarcinoma, and gallbladder cancer.
  • Endoscopic retrograde cholangiopancreatography and direct cholangioscopy revealed a mass at the biliary bifurcation, a 4-cm choledochal cyst with multiple calculi, absence of anomalous pancreaticobiliary ductal union, and multiple calcifications in the pancreatic head.
  • We report the associated rare finding of chronic calcific pancreatitis, without anomaly of the pancreatic biliary junction.
  • [MeSH-minor] Adult. Biopsy. Cholangiopancreatography, Endoscopic Retrograde. Female. Humans. Pancreatitis, Chronic / diagnosis. Pancreatitis, Chronic / etiology

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  • (PMID = 18274902.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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47. Tanyi M, Olasz J, Lukács G, Tanyi JL, Tóth L, Antal-Szalmás P, Ress Z, Bubán T, András C, Damjanovich L: A new mutation in Muir-Torre syndrome associated with familiar transmission of different gastrointestinal adenocarcinomas. Eur J Surg Oncol; 2009 Oct;35(10):1128-30
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  • A 57 years old male patient is presented with a mucinous carcinoma of the caecum and an adenocarcinoma of the pancreas head.
  • His family history was significant for two cases of colon carcinoma, two cases of stomach cancer and a case of metacron endometrial and skin tumor as well.
  • [MeSH-minor] Adenocarcinoma, Mucinous / genetics. Adenocarcinoma, Mucinous / pathology. Cecal Neoplasms / genetics. Cecal Neoplasms / pathology. Family Health. Humans. Male. Middle Aged. Pancreatic Neoplasms / genetics. Pancreatic Neoplasms / pathology. Pedigree

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  • (PMID = 19423266.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / MLH1 protein, human; 0 / MLH2 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins
  • [Number-of-references] 15
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48. Loos M, Bergmann F, Bauer A, Hoheisel JD, Esposito I, Kleeff J, Schirmacher P, Büchler MW, Klöppel G, Friess H: Solid type clear cell carcinoma of the pancreas: differential diagnosis of an unusual case and review of the literature. Virchows Arch; 2007 Jun;450(6):719-26
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  • [Title] Solid type clear cell carcinoma of the pancreas: differential diagnosis of an unusual case and review of the literature.
  • Pancreatic neoplasms have been reliably classified on the basis of their histopathology and immunophenotype.
  • In this study, we report on a pancreatic tumor whose phenotype and genotype could not be assigned to any known tumor entity.
  • The tumor was observed in the pancreatic head of a 54-year-old woman.
  • DNA microarray analysis revealed a transcription profile clearly differing from that of normal pancreatic tissue and pancreatic ductal adenocarcinoma.
  • Despite metastatic behavior, the tumor displayed a more favorable course than conventional pancreatic ductal adenocarcinoma.
  • We suggest that this tumor be called solid type clear cell carcinoma of the pancreas.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Gene Expression Profiling. Humans. Immunohistochemistry. Keratins / metabolism. Liver Neoplasms / diagnostic imaging. Liver Neoplasms / secondary. Microarray Analysis. Middle Aged. Mucin-1 / metabolism. Oligonucleotide Array Sequence Analysis. Reverse Transcriptase Polymerase Chain Reaction. S100 Proteins / metabolism. Tomography, Spiral Computed. Vimentin / metabolism

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  • (PMID = 17453235.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / MUC1 protein, human; 0 / Mucin-1; 0 / S100 Proteins; 0 / Vimentin; 68238-35-7 / Keratins
  • [Number-of-references] 39
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49. Fujimori N, Nakamura T, Oono T, Igarashi H, Takahata S, Nakamura M, Tanaka M, Hayashi A, Aishima S, Ishigami K, Ogoshi K, Ito T, Takayanagi R: Adenocarcinoma involving the whole pancreas with multiple pancreatic masses. Intern Med; 2010;49(15):1527-32
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  • [Title] Adenocarcinoma involving the whole pancreas with multiple pancreatic masses.
  • A 77-year-old man was referred to our hospital for further investigation of pancreatic masses.
  • Imaging studies revealed hypovascular masses in the pancreatic head and body.
  • Total pancreatectomy was performed under the diagnosis of double primary pancreatic carcinomas.
  • Macroscopic examination revealed 3 nodules: one each in the pancreatic head, body, and tail.
  • Incidentally, we also identified an adenocarcinoma of the common bile duct (CBD).
  • The final diagnosis was synchronous double cancer involving the whole pancreas and the CBD.
  • [MeSH-major] Adenocarcinoma / diagnosis. Common Bile Duct Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Pancreatic Neoplasms / diagnosis

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  • (PMID = 20686284.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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50. Chan M, Scaife C, Thaker HM, Adler DG: Adenocarcinoma of the pancreas undetected by multidetector CT, endoscopic ultrasound, or intraoperative ultrasound. JOP; 2009;10(5):554-6
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  • [Title] Adenocarcinoma of the pancreas undetected by multidetector CT, endoscopic ultrasound, or intraoperative ultrasound.
  • CONTEXT: Patients with known or suspected pancreatic adenocarcinoma are typically evaluated with noninvasive imaging studies and endoscopic ultrasound.
  • Some patients have pancreatic adenocarcinomas that cannot be detected using any of these methods.
  • Multiple endoscopic ultrasound and triple phase pancreatic protocol CT exams were negative for a mass lesion and revealed a normal pancreas.
  • Intraoperative ultrasound of the pancreas was also felt to be normal.
  • Intraoperative biopsy of the head of the pancreas revealed a small, moderately to poorly differentiated adenocarcinoma, not visible on any of her imaging studies.
  • CONCLUSION: Some pancreatic adenocarcinomas may defy detection using modern imaging modalities.
  • [MeSH-major] Adenocarcinoma / diagnosis. Diagnostic Errors. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Cholangiopancreatography, Endoscopic Retrograde / methods. Delayed Diagnosis. Endosonography / methods. Female. Humans. Intraoperative Period. Middle Aged. Tomography, X-Ray Computed / methods. Ultrasonography, Interventional

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  • (PMID = 19734637.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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51. Dhall D, Suriawinata AA, Tang LH, Shia J, Klimstra DS: Use of immunohistochemistry for IgG4 in the distinction of autoimmune pancreatitis from peritumoral pancreatitis. Hum Pathol; 2010 May;41(5):643-52
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  • The patients with autoimmune pancreatitis usually present with jaundice and a pancreatic head mass, presumed to have pancreatic cancer, and they often undergo pancreatic resection.
  • Elevated serum IgG4 levels (>135 mg/dL) help to distinguish autoimmune pancreatitis from pancreatic cancer.
  • However, when the biopsy from a pancreatic mass shows dense chronic inflammation and fibrosis and the serum IgG4 level is not available, it presents a diagnostic dilemma whether it represents autoimmune pancreatitis or peritumoral pancreatitis.
  • We performed IgG4 immunohistochemistry on 25 cases of autoimmune pancreatitis-lymphoplasmacytic sclerosing pancreatitis, 7 cases of autoimmune pancreatitis with granulocytic epithelial lesions, 8 cases of nonspecific pancreatitis, 15 cases of pancreatitis associated with pancreatic ductal adenocarcinoma, and 5 biopsies of pancreatic adenocarcinoma with variable inflammation.
  • [MeSH-major] Autoimmune Diseases / diagnosis. Carcinoma, Pancreatic Ductal / diagnosis. Immunoglobulin G / immunology. Pancreas / immunology. Pancreatic Neoplasms / diagnosis. Pancreatitis / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD / immunology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged. Plasma Cells / immunology


52. Shtilbans V, Wu M, Burstein DE: Current overview of the role of Akt in cancer studies via applied immunohistochemistry. Ann Diagn Pathol; 2008 Apr;12(2):153-60
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  • [Title] Current overview of the role of Akt in cancer studies via applied immunohistochemistry.
  • The following review summarizes the use of phospho-AKT immunohistochemistry as a potentially valuable tool in cancer prognostication in a wide spectrum of common and uncommon malignancies, including squamous carcinoma of cervix and of head and neck; adenocarcinoma of endometrium, ovarian, breast, prostate, kidney, colon, and pancreas; carcinomas of lung and thyroid; and hematopoietic, soft tissue, and central nervous system neoplasms.
  • To date, the findings overall suggest that the major use of p-AKT immunohistochemical staining lies in prognostication and possibly in individualization of therapy rather than in differential diagnosis.

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  • (PMID = 18325479.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
  • [Number-of-references] 79
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53. Pai RK, West RB: MOC-31 exhibits superior reactivity compared with Ber-EP4 in invasive lobular and ductal carcinoma of the breast: a tissue microarray study. Appl Immunohistochem Mol Morphol; 2009 May;17(3):202-6
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  • Distinguishing between reactive mesothelial proliferations and adenocarcinoma is often very difficult.
  • MOC-31 and Ber-EP4 are antibodies which target the epithelial cell adhesion molecule (Ep-CAM, TACSTD1) expressed in epithelial cells, and both are useful in distinguishing metastatic adenocarcinoma from reactive mesothelial cells.
  • We analyzed the immunohistochemical expression of MOC-31 and Ber-EP4 using tissue microarrays containing invasive ductal carcinoma (191 cases), invasive lobular carcinoma (44 cases), and 102 other carcinoma types comprising primary carcinomas of lung, gynecologic tract, pancreas, colon, gastric, esophageal, prostate, head and neck, hepatic, and renal origin.
  • With the exception of 1 case of esophageal adenocarcinoma, all other adenocarcinomas (86 of 87 cases) exhibited diffuse staining with both Ber-EP4 and MOC-31.

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  • (PMID = 19391212.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Cell Adhesion Molecules; 0 / EPCAM protein, human
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54. Akatsu T, Kameyama K, Nogami Y, Kawachi S, Kitajima M, Kitagawa Y: Neoplastic endocrine differentiation of pancreatic ductal adenocarcinoma in a metastatic lymph node: report of a case. Surg Today; 2007;37(11):1009-12
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  • [Title] Neoplastic endocrine differentiation of pancreatic ductal adenocarcinoma in a metastatic lymph node: report of a case.
  • The occurrence of non-neoplastic, scattered endocrine cells in pancreatic ductal adenocarcinoma (DAC) is thought to be a general phenomenon.
  • Conversely, neoplastic endocrine differentiation (NED) of pancreatic DAC is extremely unusual.
  • We report a case of NED in a metastatic lymph node from pancreatic DAC.
  • This case is distinct because the main tumor of the pancreas was composed purely of DAC without endocrine differentiation, and the NED was found in only one of four metastatic peripancreatic lymph nodes.
  • The patient was a 61-year-old woman who underwent pylorus-preserving pancreaticoduodenectomy for pancreatic head cancer.
  • Some authors reported that pancreatic DAC with endocrine differentiation was associated with a better prognosis than DAC without endocrine differentiation.
  • However, more cases must be studied to investigate the impact of NED of metastatic lymph nodes in pancreatic DAC.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / secondary. Pancreatic Neoplasms / pathology. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Diagnosis, Differential. Endoscopy, Gastrointestinal. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 17952537.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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55. Ray B, New NE, Wedgwood KR: Clear cell carcinoma of exocrine pancreas: a rare tumor with an unusual presentation. Pancreas; 2005 Mar;30(2):184-5
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  • [Title] Clear cell carcinoma of exocrine pancreas: a rare tumor with an unusual presentation.
  • Metastatic clear cell carcinomas are relatively common from primary tumors arising in the kidney, female genital tract, adrenal cortex, and lung, but they rarely occur from primary tumors of the pancreas.
  • We report a case of metastatic pancreatic tumor with marked clear cell changes in a 46-year-old white man presenting with a pseudocyst of the pancreas.
  • At laparotomy, there was a hard area in the head of the pancreas and another hard nodule was present in the omentum.
  • The histologic and immunohistochemical test of the excised omental nodule exhibited features consistent with clear cell carcinoma from pancreatic primary.
  • To our knowledge, this is the first report of a metastatic clear cell pancreatic tumor with such an unusual presentation.
  • [MeSH-major] Adenocarcinoma, Clear Cell / secondary. Omentum / pathology. Pancreas, Exocrine / pathology. Pancreatic Neoplasms / pathology. Pancreatic Pseudocyst / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 15714142.001).
  • [ISSN] 1536-4828
  • [Journal-full-title] Pancreas
  • [ISO-abbreviation] Pancreas
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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56. Jiang KR, Miao Y: [Standard with extended pancreaticoduodenectomy for adenocarcinoma of the head of the pancreas: a meta-analysis]. Zhonghua Wai Ke Za Zhi; 2007 Jan 1;45(1):9-16
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  • [Title] [Standard with extended pancreaticoduodenectomy for adenocarcinoma of the head of the pancreas: a meta-analysis].
  • OBJECTIVE: To compare standard with extended pancreaticoduodenectomy for adenocarcinoma of the head of the pancreas: a meta-analysis of randomized controlled trials and prospective studies.
  • METHODS: Randomized controlled trials and prospective studies comparing standard with extended pancreaticoduodenectomy for pancreatic cancer of head were identified using a systematic search of Medline, the Cochrane Library Databases and CBMDisc covering articles published from 1996 to 2005.
  • Whipple procedure is also of choice for pancreatic head carcinoma and extended pancreaticoduodenectomy is indicated for lymph node positive patient (A-level).
  • [MeSH-major] Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / methods

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  • (PMID = 17403281.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Meta-Analysis
  • [Publication-country] China
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57. Schmid RM: [Pancreatic cancer]. Praxis (Bern 1994); 2006 Nov 1;95(44):1709-12
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  • [Title] [Pancreatic cancer].
  • Pancreatic cancer is the fourth leading cause of death due to cancer.
  • The most common cancer in the pancreas is ductal adenocarcinoma.
  • Pancreatic cancer is characterized by alterations in K-Ras, INK4a, Tp53 and SMAD4.
  • Similar to colon cancer a cancer progression model for pancreatic cancer has been proposed.
  • The precursor lesions are called pancreatic intraepithelial neoplasia.
  • Patients with tumors in the head of the pancreas may present deep jaundice without pain.
  • Multidetector CT incorporating dual-phase imaging in the arterial and venous phases of enhancement is the preferred imaging modality for the diagnosis and staging of pancreatic cancer.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / diagnosis. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Carcinoma in Situ / diagnosis. Carcinoma in Situ / pathology. Carcinoma in Situ / surgery. Cyclin-Dependent Kinase Inhibitor p16 / genetics. Deoxycytidine / analogs & derivatives. Deoxycytidine / therapeutic use. Gene Expression Regulation, Neoplastic / genetics. Genes, ras / genetics. Humans. Palliative Care. Pancreas / pathology. Pancreatectomy. Prognosis. Smad4 Protein / genetics. Tomography, X-Ray Computed. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 17111879.001).
  • [ISSN] 1661-8157
  • [Journal-full-title] Praxis
  • [ISO-abbreviation] Praxis (Bern 1994)
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / SMAD4 protein, human; 0 / Smad4 Protein; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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58. Inagaki M, Obara M, Suzuki S, Ishizaki A, Takahashi K, Matsumoto K, Haneda M, Tokusashi Y, Miyokawa N, Kasai S: Mucinous carcinoma of Vater's ampulla with a unique extension along the main pancreatic duct. J Hepatobiliary Pancreat Surg; 2007;14(5):518-21
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  • [Title] Mucinous carcinoma of Vater's ampulla with a unique extension along the main pancreatic duct.
  • We report a case of mucinous carcinoma of Vater's ampulla with a unique extension along only the main pancreatic duct (MPD) and microinvasion to the pancreas.
  • Abdominal computed tomography (CT) demonstrated swelling in the head of the pancreas with a mass in the duodenum.
  • A biopsy specimen of the tumor showed moderately differentiated adenocarcinoma.
  • A pylorus-preserving pancreaticoduodenectomy with a regional lymphadenectomy was performed, under a preoperative diagnosis of adenocarcinoma of Vater's ampulla with direct invasion into the head of the pancreas.
  • Microscopically, the tumor consisted of two components: moderately differentiated adenocarcinoma in the peripheral region of the tumor Vater's papilla and mucinous carcinoma in the central region of the tumor.
  • The mucinous carcinoma component uniquely extended along only the MPD with microinvasion to the pancreas.
  • Immunohistochemically, both the moderately differentiated adenocarcinoma and the mucinous carcinoma were positive for cytokeratin 20 (CK20) and negative for cytokeratin 7 (CK7) which is the pattern of intestinal-type carcinoma of Vater's ampulla.
  • We concluded that the original site of this tumor may have been the duodenal epithelium of Vater's ampulla originally moderately differentiated adenocarcinoma-which subsequently changed to mucinous carcinoma that extended along only the MPD with microinvasion to the pancreas.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 17909724.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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59. Sugimoto M, Yasuda H, Koda K, Suzuki M, Yamazaki M, Tezuka T, Kosugi C, Higuchi R, Takenoue T, Yamamoto S, Watayo Y, Yagawa Y, Tsuchiya T: Virtual CO2 MDCT pancreatography: a new feasible technique for minimally invasive pancreatectomy in intraductal papillary mucinous neoplasms. Hepatogastroenterology; 2008 Jan-Feb;55(81):270-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND/AIMS: Less invasive pancreatic head resection, such as duodenum-preserving pancreatic head resection (DPPHR) has been introduced for the treatment of pancreatoduodenal lesions, especially for benign conditions, for reducing surgical stress and maintaining exocrine and endocrine function of the residual pancreas in consideration of postoperative quality of life (QOL).
  • METHODOLOGY: We investigated the feasibility of a new technique employing three-dimensional (3D) virtual pancreatography using multi-detector CT (MDCT) with carbon dioxide (CO2) gas as a negative contrast agent for detection of intraductal papillary mucinous neoplasm (IPMN) of the pancreas requiring minimally invasive surgery.
  • RESULTS: Contrast-enhanced MDCT scan of the abdomen diagnosed 4- to 20-mm multilocular septated cysts in the head-uncinate process of the pancreas.
  • Endoscopic retrograde pancreatography (ERP) showed multiple cystic lesions in the head-uncinate process with mild dilatation in the remaining pancreatic duct.
  • For localizing diagnosis of these small and multiple pancreatic cysts, we placed an endoscopic pancreatic stent (EPS), and MDCT with injection of CO2 via EPS was examined for the virtual CO2 pancreatography, consisting of OsiriX software system employing 3D virtual anatomic reconstruction with CO2 gas as a negative contrast agent.
  • Virtual CO2 MDCT pancreatography demonstrated that all cystic lesions of the pancreas were contained within the area of the head-uncinate process of the pancreas.
  • We performed DPPHR, and surgical margin of the patient's remnant pancreas was determined as non-malignant by intraoperative histology.
  • There was no residual pancreatic cyst and tumor after surgery.
  • The resected tumor was diagnosed as branch duct type intraductal papillary mucinous adenocarcinoma.
  • According to our minimally invasive DPPHR obtained by virtual CO2 pancreatography, the pancreatic endocrine and exocrine functions of this patient were maintained at almost the same levels as those in his preoperative status.
  • With respect to preservation of the endocrine and exocrine functions of the pancreas, DPPHR is a highly effective surgical procedure due to limited surgical resection.
  • CONCLUSIONS: Our new technique of virtual CO2 MDCT pancreatography is a feasible procedure for preservation of the remnant pancreatic function.
  • This is the first report of virtual CO2 pancreatography providing minimally invasive pancreatic surgery.
  • [MeSH-major] Adenocarcinoma, Mucinous / surgery. Adenocarcinoma, Papillary / surgery. Carcinoma, Pancreatic Ductal / radiography. Carcinoma, Pancreatic Ductal / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / radiography. Pancreatic Neoplasms / surgery. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Carbon Dioxide. Cholangiopancreatography, Endoscopic Retrograde. Dilatation, Pathologic. Feasibility Studies. Humans. Pancreatic Ducts / pathology

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  • (PMID = 18507123.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 142M471B3J / Carbon Dioxide
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60. Sanada Y, Yoshida K, Itoh M, Okita R, Okada M: Invasive ductal carcinoma of the pancreas showing exophytic growth. Hepatobiliary Pancreat Dis Int; 2009 Feb;8(1):97-102
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  • [Title] Invasive ductal carcinoma of the pancreas showing exophytic growth.
  • BACKGROUND: Invasive pancreatic carcinoma generally appears as poorly defined mass reflecting the infiltrative growth.
  • We aimed to identify the histological and immunohistochemical features in a rare case of pancreatic carcinoma showing exophytic growth.
  • METHODS: A 67-year-old woman presented with a mass of 5.0 cm in diameter in the pancreatic head.
  • Magnetic resonance cholangiopancreatography revealed neither encasement nor dilation of the main pancreatic duct.
  • An incorrect preoperative diagnosis was made of solid pseudopapillary tumor of the pancreas.
  • RESULTS: The head of the pancreas contained a well-circumscribed encapsulated mass of 5.0 cm in diameter, comprising 50% adenocarcinoma, with mucinous carcinoma in the center and anaplastic carcinoma at the periphery.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoma, Pancreatic Ductal / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 19208524.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Mucin-1
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61. M'sakni I, Rammeh S, Chelbi E, Sayari S, Zaouech A, Baltagi-Ben Jilani S, Zermani R: [Adenocarcinoma and gastro-intestinal stromal tumor: fortuitous association or a single carcinogenic agent? A report of 2 cases]. Ann Chir; 2006 Oct;131(8):464-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenocarcinoma and gastro-intestinal stromal tumor: fortuitous association or a single carcinogenic agent? A report of 2 cases].
  • One is of a 44-year-old man presenting a high grade gastric stromal tumor associated with an adenocarcinoma of the large bowel.
  • The other is of a 68-year-old man presenting an adenocarcinoma of the head of the pancreas associated with a low grade gastric stromal tumor.
  • The hypothesis that the association is due to a simple coincidence particularly in areas with high rates of digestive cancer is proposed.
  • [MeSH-major] Adenocarcinoma. Colonic Neoplasms. Gastrointestinal Stromal Tumors. Neoplasms, Multiple Primary. Pancreatic Neoplasms
  • [MeSH-minor] Adult. Colectomy. Colon / pathology. Colonoscopy. Humans. Male. Middle Aged. Pancreas / pathology. Radiography, Abdominal. Tomography, X-Ray Computed

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  • (PMID = 16527243.001).
  • [ISSN] 0003-3944
  • [Journal-full-title] Annales de chirurgie
  • [ISO-abbreviation] Ann Chir
  • [Language] fre
  • [Publication-type] Case Reports; Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
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62. Tanaka H, Takamori H, Eto S, Ozaki N, Akaboshi S, Nakahara O, Ida S, Furuhashi S, Abe S, Horino K, Beppu T, Baba H: [Acute liver injury with hepatic encephalopathy associated with gemcitabine administration for adjuvant chemotherapy in an HBV carrier with pancreatic cancer]. Gan To Kagaku Ryoho; 2010 Sep;37(9):1783-6
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  • [Title] [Acute liver injury with hepatic encephalopathy associated with gemcitabine administration for adjuvant chemotherapy in an HBV carrier with pancreatic cancer].
  • Imagings revealed cancer of the head of the pancreas.
  • We performed pancreaticoduodenectomy for pancreatic cancer.
  • The histopathological diagnosis was tubular adenocarcinoma of the pancreas.
  • [MeSH-major] Deoxycytidine / analogs & derivatives. Hepatic Encephalopathy / chemically induced. Hepatitis B / complications. Liver / injuries. Pancreatic Neoplasms / drug therapy


63. Fukatsu H, Kawamoto H, Tsutsumi K, Fujii M, Kato H, Hirao K, Kurihara N, Ogawa T, Ishida E, Okamoto Y, Okada H, Sakaguchi K: Santorinicele in a patient with unresectable pancreatic cancer. Intern Med; 2008;47(1):33-5
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  • [Title] Santorinicele in a patient with unresectable pancreatic cancer.
  • A santorinicele is defined as a focal cystic dilatation of the terminal portion of the dorsal pancreatic duct at the minor papilla; most cases have been reported in patients with pancreas divisum.
  • It has been suggested that a santorinicele results from a combination of a minor papilla obstruction which prevents the flow of pancreatic juice and a weakness of the duodenal wall where the dorsal pancreatic duct terminates.
  • However, these conditions can occur in patients with invasive ductal cancer in the pancreatic head.
  • We encountered a rare case of a santorinicele with unresectable adenocarcinoma of the pancreatic head in an 81-year-old woman.
  • [MeSH-major] Adenocarcinoma / complications. Pancreatic Cyst / etiology. Pancreatic Ducts. Pancreatic Neoplasms / complications
  • [MeSH-minor] Aged, 80 and over. Cholangiopancreatography, Endoscopic Retrograde. Dilatation, Pathologic / diagnosis. Dilatation, Pathologic / etiology. Female. Humans

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  • (PMID = 18176002.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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64. Baierlein SA, Wistop A, Looser C, Bussmann C, von Flüe M, Peterli R: Primary pancreatic neoplasia or metastasis from colon carcinoma? Acta Gastroenterol Belg; 2008 Oct-Dec;71(4):401-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary pancreatic neoplasia or metastasis from colon carcinoma?
  • INTRODUCTION: The pancreas is an unusual but occasionally favored target for metastasis from other primary cancers.
  • CASE REPORT: We report the case of a 77-year old man with a mass in the pancreatic head five years after anterior resection for adenocarcinoma of the colon and three years after resection of a lung metastasis.
  • DISCUSSION: It is rare to have solitary metastases to the pancreas which clinically may mimic a primary neoplasm of the pancreas.
  • Clinical features, as well as MRI and PET findings in patients with pancreatic metastasis from colon carcinoma are similar to those of primary pancreatic ductal adenocarcinoma.
  • The diagnosis of metastasis should be considered when patients have a pancreatic mass and a history of non-pancreatic malignant lesions.
  • Radical resection may prolong survival in patients if the pancreas is the only locus for metastasis at the time of diagnosis.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Colonic Neoplasms / pathology. Neoplasms, Second Primary / diagnosis. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / secondary
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male

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  • (PMID = 19317283.001).
  • [ISSN] 1784-3227
  • [Journal-full-title] Acta gastro-enterologica Belgica
  • [ISO-abbreviation] Acta Gastroenterol. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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65. Farnell MB, Aranha GV, Nimura Y, Michelassi F: The role of extended lymphadenectomy for adenocarcinoma of the head of the pancreas: strength of the evidence. J Gastrointest Surg; 2008 Apr;12(4):651-6
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  • [Title] The role of extended lymphadenectomy for adenocarcinoma of the head of the pancreas: strength of the evidence.
  • Standard pancreaticoduodenectomy continues to be the operation of choice for adenocarcinoma of the head of the pancreas.
  • [MeSH-major] Adenocarcinoma / surgery. Lymph Node Excision / methods. Pancreatic Neoplasms / surgery

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  • (PMID = 18085343.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 22
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66. Shima Y, Yagi T, Inagaki M, Sadamori H, Tanaka N, Horimi T, Hamazaki S: Intraductal oncocytic papillary neoplasm of the pancreas with celiac artery compression syndrome and a jejunal artery aneurysm: report of a case. Surg Today; 2005;35(1):86-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraductal oncocytic papillary neoplasm of the pancreas with celiac artery compression syndrome and a jejunal artery aneurysm: report of a case.
  • A 79-year-old woman presented with epigastralgia, and computed tomography showed a 3-cm multiloculated mass with a mural nodule in the head of the pancreas.
  • We made a preoperative diagnosis of intraductal papillary adenocarcinoma of the pancreatic head and performed a laparotomy.
  • Microscopically, the tumor had papillary intracystic growth, and was lined by plump cells with abundant eosinophilic cytoplasm, consistent with a diagnosis of intraductal oncocytic papillary neoplasm.
  • We discuss this recently recognized entity of papillary neoplasm of the pancreas, and the importance of managing hepatic blood flow during pancreaticoduodenectomy in celiac artery compression syndrome.
  • [MeSH-major] Adenocarcinoma, Papillary / surgery. Arterial Occlusive Diseases / radiography. Celiac Artery. Jejunum / blood supply. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Abdominal Pain / diagnosis. Abdominal Pain / etiology. Aged. Aneurysm / radiography. Aneurysm / surgery. Angiography. Female. Follow-Up Studies. Humans. Risk Assessment. Severity of Illness Index. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 15622472.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 16
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67. Bach P, Möhring C, Krawzak HW, Goepel M: [Retroperitoneal extravasation as the primary symptom of a pancreatic carcinoma]. Urologe A; 2007 Nov;46(11):1548-50
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  • [Title] [Retroperitoneal extravasation as the primary symptom of a pancreatic carcinoma].
  • Adenocarcinoma of the pancreas has a low 5-year survival rate of approximately 5%.
  • Early diagnostics of pancreatic carcinoma during early tumor stages is made difficult by the lack of symptoms.
  • In particular, individuals suffering from carcinomas located within the pancreatic tail are at high risk of a missed diagnosis.
  • The early symptoms are usually nonspecific (e.g., nonspecific upper abdominal complaints, decrease in weight, loss of appetite, and impaired performance) and are characteristic only in carcinomas of the pancreatic head with painless icterus.
  • An adenocarcinoma of the pancreatic tail was diagnosed in this case report based on a large retroperitoneal extravasation missing further symptoms.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnostic imaging. Extravasation of Diagnostic and Therapeutic Materials / diagnostic imaging. Pancreatic Neoplasms / diagnostic imaging
  • [MeSH-minor] Aorta, Abdominal / pathology. Diagnosis, Differential. Duodenum / pathology. Gastroenterostomy. Humans. Male. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Staging. Palliative Care. Retroperitoneal Space / diagnostic imaging. Tomography, X-Ray Computed. Ureter / pathology. Urinoma / diagnostic imaging. Urography

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  • (PMID = 17786402.001).
  • [ISSN] 0340-2592
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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68. Pine JK, Fusai KG, Young R, Sharma D, Davidson BR, Menon KV, Rahman SH: Serum C-reactive protein concentration and the prognosis of ductal adenocarcinoma of the head of pancreas. Eur J Surg Oncol; 2009 Jun;35(6):605-10
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  • [Title] Serum C-reactive protein concentration and the prognosis of ductal adenocarcinoma of the head of pancreas.
  • BACKGROUND: The prognostic role of serum C-reactive protein in pancreatic cancer has received increasing attention; however the confounding effects of biliary obstruction have not been addressed in previous studies.
  • We sought to determine the prognostic importance of serum CRP prior to biliary intervention in the prognosis of pancreatic adenocarcinoma.
  • METHODS: A retrospective case note review of patients diagnosed with pancreatic cancer between 2001 and 2006.
  • CONCLUSION: Raised serum C-reactive protein concentration at the time of presentation of advanced pancreatic cancer carries a poor prognosis independent of biliary tract obstruction.
  • [MeSH-major] C-Reactive Protein / analysis. Carcinoma, Pancreatic Ductal / blood. Pancreatic Neoplasms / blood

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  • (PMID = 19128923.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 9007-41-4 / C-Reactive Protein
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69. Gumbs AA, Kim J, Kiehna E, Brink JA, Salem RR: Autoimmune pancreatitis presenting as simultaneous masses in the pancreatic head and gallbladder. JOP; 2005 Sep;6(5):455-9
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  • [Title] Autoimmune pancreatitis presenting as simultaneous masses in the pancreatic head and gallbladder.
  • CONTEXT: Autoimmune pancreatitis is a rare variant of chronic pancreatitis characterized by pancreatic ductal narrowing and pancreatic parenchymal edema on computed tomography and rarely with intermittent attacks of abdominal pain.
  • CASE REPORT: We describe the clinical, radiographic and histopathologic aspects of a patient who presented with synchronous masses in the pancreatic head and gallbladder.
  • CONCLUSION: Autoimmune pancreatitis is the most common benign entity identified in patients that underwent pancreaticoduodenectomy for presumed pancreatic adenocarcinoma.
  • Our patient with autoimmune pancreatitis presented with simultaneous inflammatory masses in the gallbladder and pancreatic head, an association not previously reported.
  • If pre-operative diagnosis is not made, immunohistochemical staining of pathology specimens can confirm the diagnosis.
  • [MeSH-major] Autoimmune Diseases / diagnosis. Autoimmune Diseases / pathology. Gallbladder / pathology. Pancreas / pathology. Pancreatitis / diagnosis. Pancreatitis / pathology
  • [MeSH-minor] Acute Disease. Aged. Edema / diagnosis. Edema / pathology. Female. Humans. Immunoglobulin G / analysis. Immunoglobulin G / blood. Immunohistochemistry. Tomography, X-Ray Computed

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  • (PMID = 16186668.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Immunoglobulin G
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70. Garcea G, Dennison AR, Ong SL, Pattenden CJ, Neal CP, Sutton CD, Mann CD, Berry DP: Tumour characteristics predictive of survival following resection for ductal adenocarcinoma of the head of pancreas. Eur J Surg Oncol; 2007 Sep;33(7):892-7
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  • [Title] Tumour characteristics predictive of survival following resection for ductal adenocarcinoma of the head of pancreas.
  • AIMS: We have maintained a highly conservative policy in selecting patients with carcinoma of the head of pancreas for resection.
  • This study investigated our survival rates following pancreatic resection and examined clinicopathological predictors of survival.
  • METHODS: Sixty-two consecutive patients undergoing pancreatic resections for malignancy were identified from 1999 onwards.
  • Thirty-three underwent resection for pancreatic ductal adenocarcinoma and were included in our analysis, the remainder included resections for ampullary adenocarcinoma (n=20) or other malignancies (n=9).
  • RESULTS: Median survival following resection for ductal pancreatic adenocarcinoma was 54 months (ampullary adenocarcinomas achieved a median survival of 62 months) and thirty-day mortality was 2.7% (n=1).
  • CONCLUSION: Despite the advances made in the management of pancreatic cancer, tumour biology still dictates long-term survival.
  • [MeSH-major] Carcinoma, Ductal / mortality. Pancreatectomy / methods. Pancreatic Neoplasms / mortality

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  • (PMID = 17398060.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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71. Matsubayashi H, Matsunaga K, Uesaka K, Fukutomi A, Sasaki K, Furukawa H, Ono H: A case of pancreatic carcinoma with suspected autoimmune pancreatitis. Clin J Gastroenterol; 2009 Feb;2(1):59-63
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  • [Title] A case of pancreatic carcinoma with suspected autoimmune pancreatitis.
  • We present a case of pancreatic carcinoma with strongly suspected coexisting autoimmune pancreatitis (AIP).
  • The patient presented with a chief complaint of icterus and weight loss, and was referred to our institution after a pancreatic lesion was found.
  • Ultrasonography demonstrated an enlarged pancreas with smooth borders and low internal echo density.
  • Enhanced computed tomography (CT) showed a sausage-shaped pancreas without definitive metastasis to the surrounding lymph nodes and liver.
  • Imaging of the pancreatic duct, including endoscopic retrograde pancreatography (ERP) and magnetic resonance cholangiopancreatography (MRCP), showed stenosis of the main pancreatic duct at the pancreatic head as well as a long segment of narrowing at the body and no dilatation at the tail.
  • Tissues from these stenotic sites and open biopsy from pancreatic body showed infiltrating adenocarcinoma and dense fibrosis.
  • To date, only a small number of reports have described pancreatic carcinoma accompanied with AIP.
  • It is important to confirm diagnosis with histology in cases of suspicious autoimmune pancreatitis, even when the clinical images are compatible with AIP.

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  • (PMID = 26191812.001).
  • [ISSN] 1865-7257
  • [Journal-full-title] Clinical journal of gastroenterology
  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Auto-antibody / Autoimmune pancreatitis / IgG4 / Pancreatic carcinoma
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72. Takahashi S, Homma H, Akiyama T, Mesawa S, Hirata K, Kogawa K, Takanashi K, Ishiwatari H, Kawano Y, Hayashi T, Takada K, Miyanishi K, Kato J, Niitsu Y: [A case of intraductal papillary mucinous neoplasm with internal pancreatic fistula causing left ureteral obstruction]. Nihon Shokakibyo Gakkai Zasshi; 2007 Aug;104(8):1236-44
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  • [Title] [A case of intraductal papillary mucinous neoplasm with internal pancreatic fistula causing left ureteral obstruction].
  • A 75-year-old man had been admitted to another hospital because of left abdominal pain, and was given a diagnosis of left hydronephrosis and acute pancreatitis.
  • US and EUS revealed a chronic pancreatitis-like pattern and multicystic lesion in the pancreas head and body.
  • At that time enhanced CT findings showed an extrapancreatic low density area to be inflammatory change, extending from the pancreas body to the left crus of the diaphragm and posteriorly the spreading from the left crus of the diaphragm via the left urinary duct into the left iliopsoas muscle, in which MRI revealed partial high intensity.
  • ERCP and MRCP showed focal irregular narrowing of the pancreatic duct of unknown cause, and we decided that an internal pancreatic fistula due to pancreatitis had induced left ureteral obstruction, caused by a protein plug or alcohol.
  • [MeSH-major] Adenocarcinoma, Mucinous / complications. Carcinoma, Pancreatic Ductal / complications. Pancreatic Fistula / complications. Pancreatic Neoplasms / complications. Ureteral Obstruction / etiology

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  • (PMID = 17675827.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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73. Lopez-Tomassetti Fernandez EM, Luis HD, Malagon AM, Gonzalez IA, Pallares AC: Recurrence of inflammatory pseudotumor in the distal bile duct: lessons learned from a single case and reported cases. World J Gastroenterol; 2006 Jun 28;12(24):3938-43
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  • Immunohistochemical study of these lesions limited to the pancreatic head or distal bile duct seems to be compatible with those observed in a new entity called autoimmune pancreatitis, but usually intense fibrotic reaction (zonation) predominates producing a mass.
  • When this condition is limited to the pancreatic head, the common bile duct might be involved by the inflammatory process and jaundice may occur often resembling adenocarcinoma of the pancreas.
  • Ultrasound-guided FNA confirmed our suspicious diagnosis.
  • [MeSH-minor] Adrenal Cortex Hormones / therapeutic use. Autoimmune Diseases / classification. Autoimmune Diseases / diagnosis. Autoimmune Diseases / pathology. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Pancreatitis / classification. Pancreatitis / diagnosis. Pancreatitis / pathology. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 16804988.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones
  • [Number-of-references] 52
  • [Other-IDs] NLM/ PMC4087951
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74. Adsay NV: Cystic neoplasia of the pancreas: pathology and biology. J Gastrointest Surg; 2008 Mar;12(3):401-4
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  • [Title] Cystic neoplasia of the pancreas: pathology and biology.
  • In contrast with solid tumors, most of which are invasive ductal adenocarcinoma with dismal prognosis, cystic lesions of the pancreas are often either benign or low-grade indolent neoplasia.
  • For this reason, pancreatic cysts with mucinous differentiation ought to be evaluated carefully, preferably by experts familiar with subtle evidences of malignancy in these tumors.
  • The presence of ovarian-type stroma has now almost become a requirement for the diagnosis of MCN, and when defined as such, MCN is seen almost exclusively in women of perimenopausal age group as thick-walled multilocular cystic mass in the tail of the pancreas in contrast with IPMN which afflicts an elder population, both genders in almost equal numbers, and occur predominantly in the head of the organ.
  • SPT holds a distinctive place among pancreatic neoplasia because of its highly peculiar characteristics, undetermined cell lineage, occurrence almost exclusively in young females, association with beta-catenin pathway, and also by being a very low-grade curable malignancy.
  • In conclusion, cystic lesions in the pancreas constitute a biologically and pathologically diverse category most (but not all) of which are either benign or treatable diseases; however, a substantial subset, especially mucinous ones, has malignant potential that requires careful analysis.
  • [MeSH-major] Adenoma / pathology. Carcinoma in Situ / pathology. Neoplasms, Cystic, Mucinous, and Serous / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / pathology. Precancerous Conditions / pathology
  • [MeSH-minor] Adenocarcinoma, Mucinous / mortality. Adenocarcinoma, Mucinous / pathology. Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Papillary / mortality. Carcinoma, Papillary / pathology. Cystadenoma / pathology. Cystadenoma, Serous / pathology. Dilatation, Pathologic. Humans. Necrosis

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  • (PMID = 17957438.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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75. Todoroki T, Sano T, Yamada S, Hirahara N, Toda N, Tsukada K, Motojima R, Motojima T: Clear cell carcinoid tumor of the distal common bile duct. World J Surg Oncol; 2007;5:6
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  • Under suspicion of carcinoma, we resected the head of the pancreas along with 2nd portion duodenectomy and a lymph node dissection.
  • Immunohistochemical stains showed that neoplastic cells were positive for neuron-specific enolase (NSE), chromogranin A, synaptophysin, and pancreatic polypeptide and negative for inhibin, keratin, CD56, serotonin, gastrin and somatostatin.
  • CONCLUSION: Given the preoperative difficulty in differentiating carcinoid from carcinoma, the pancreaticoduodenectomy is an appropriate treatment choice for carcinoid tumors located within the intra-pancreatic bile duct.
  • [MeSH-major] Carcinoid Tumor / diagnosis. Carcinoid Tumor / surgery. Common Bile Duct Neoplasms / diagnosis. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Adenocarcinoma, Clear Cell / diagnosis. Adenocarcinoma, Clear Cell / pathology. Adenocarcinoma, Clear Cell / surgery. Aged. Biopsy, Needle. Cholangiopancreatography, Endoscopic Retrograde. Cholangiopancreatography, Magnetic Resonance. Follow-Up Studies. Humans. Immunohistochemistry. Laparotomy / methods. Male. Neoplasm Staging. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome. Ultrasonography, Doppler

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  • (PMID = 17227590.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 52
  • [Other-IDs] NLM/ PMC1785380
  • [General-notes] NLM/ Original DateCompleted: 20070802
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76. Fukumoto K, Suzuki S, Sakaguchi T, Morita Y, Oishi K, Suzuki A, Inaba K, Kamiya K, Miura K, Konno H: Adenocarcinoma arising from gastric duplication: a case report with literature review. Clin J Gastroenterol; 2008 Dec;1(4):148-152
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  • [Title] Adenocarcinoma arising from gastric duplication: a case report with literature review.
  • We report the case of a 50-year-old man with adenocarcinoma derived from gastric duplication.
  • Under the diagnosis of gastric duplication cysts, the oral cyst was removed with the gastric wall and the other cyst lesion firmly adhered to the bulbus was treated with distal gastrectomy.
  • Based on histological findings showing adenocarcinoma in the anal duplication cyst wall and regional lymph node metastases and cancer invasion into the duodenal stump, pancreatoduodenectomy was performed 9 days after the initial surgery.
  • Invasion into the pancreas head and duodenal walls was seen in the resected specimen.
  • This case report with literature review indicates that alimentary tract duplication cysts should be recognized as risky lesions of cancer development in patients aged 50 years or over.

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  • (PMID = 26193693.001).
  • [ISSN] 1865-7257
  • [Journal-full-title] Clinical journal of gastroenterology
  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Adenocarcinoma / Alimentary tract duplication / Cancer development / Gastric duplication cyst
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77. Salla C, Chatzipantelis P, Konstantinou P, Karoumpalis I, Sakellariou S, Pantazopoulou A, Manika Z: Endoscopic ultrasound-guided fine-needle aspiration cytology in the diagnosis of intraductal papillary mucinous neoplasms of the pancreas. A study of 8 cases. JOP; 2007;8(6):715-24
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  • [Title] Endoscopic ultrasound-guided fine-needle aspiration cytology in the diagnosis of intraductal papillary mucinous neoplasms of the pancreas. A study of 8 cases.
  • CONTEXT: Intraductal papillary mucinous neoplasm (IPMN) is an increasingly recognized neoplasm of the pancreas, accounting for 5% of pancreatic neoplasms, it is considered difficult to diagnose by fine-needle aspiration (FNA) cytology.
  • OBJECTIVE: The aim of this study was to investigate the role of EUS-guided FNA cytology in the diagnosis of IPMN of the pancreas.
  • EUS/clinical findings, macroscopic/microscopic features of cell blocks and smears, and immunocytochemical stains accompanied by histopathologic diagnosis were recorded and studied.
  • RESULTS: EUS revealed hypoechoic masses in the head of pancreas (n=6) and in the body/tail (n=2), measuring from 16.6 to 35.8 mm.
  • In all cases, the hypoechoic mass had a distinctive distribution, involving the main pancreatic duct and/or the associated large branch ducts while intraductal nodules or multiple cysts were detected.
  • The histological diagnosis confirmed the FNA cytology diagnosis: 3 malignant IPMNs, 2 benign IPMNs and 3 borderline IPMNs.
  • CONCLUSIONS: The characteristic pre-operative EUS findings and cytomorphologic features, in addition to the immunocytochemical profile, were accurate indications and coincided with the final/post-operative histological diagnosis of IPMN.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Papillary / diagnosis. Adenocarcinoma, Papillary / pathology. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / pathology


78. Nakagohri T, Kinoshita T, Konishi M, Takahashi S, Gotohda N: Nodal involvement is strongest predictor of poor survival in patients with invasive adenocarcinoma of the head of the pancreas. Hepatogastroenterology; 2006 May-Jun;53(69):447-51
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  • [Title] Nodal involvement is strongest predictor of poor survival in patients with invasive adenocarcinoma of the head of the pancreas.
  • BACKGROUND/AIMS: Pancreatic cancer is a devastating disease with an extremely poor prognosis.
  • The outcome of pancreatic head cancer after surgical resection is still difficult to predict.
  • METHODOLOGY: Between September 1992 and December 2003, 100 consecutive patients with invasive adenocarcinoma of the head of the pancreas who underwent surgical resection were retrospectively analyzed to clarify the influence of clinicopathological factors.
  • RESULTS: The overall 1-, 3-, and 5-year survival rates for the 100 patients with pancreatic head cancer were 55%, 16%, and 6%, respectively.
  • Among the 16 clinicopathologic factors, 9 were significantly associated with outcome in univariate analysis: tumor type (invasive ductal cancer), poor histological differentiation, extrapancreatic plexus invasion, bile duct invasion, duodenal invasion, intrapancreatic nerve invasion, lymphatic invasion, venous invasion, and nodal involvement.
  • CONCLUSIONS: Nodal involvement was the strongest predictor of poor survival after pancreatic resection for invasive adenocarcinoma of the head of the pancreas.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / pathology. Lymph Nodes / pathology. Pancreatic Neoplasms / mortality. Pancreatic Neoplasms / pathology

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  • (PMID = 16795990.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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79. Agarwal B, Krishna NB, Labundy JL, Safdar R, Akduman EI: EUS and/or EUS-guided FNA in patients with CT and/or magnetic resonance imaging findings of enlarged pancreatic head or dilated pancreatic duct with or without a dilated common bile duct. Gastrointest Endosc; 2008 Aug;68(2):237-42; quiz 334, 335
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  • [Title] EUS and/or EUS-guided FNA in patients with CT and/or magnetic resonance imaging findings of enlarged pancreatic head or dilated pancreatic duct with or without a dilated common bile duct.
  • BACKGROUND: Incidental findings of an enlarged head of pancreas (HOP) or dilated pancreatic duct (PD) with or without a dilated common bile duct (CBD) on CT or magnetic resonance imaging (MRI), in patients without obstructive jaundice, raise suspicion for a pancreatic neoplasm, but their clinical significance has not been established.
  • OBJECTIVE: To determine the prevalence of pancreatic neoplasm in this patient group.
  • The final diagnosis was based on definitive cytology, surgical pathology, and clinical follow-up.
  • INTERVENTIONS: An EUS examination was performed by using a radial echoendoscopy followed by a linear echoendoscopy, if a focal pancreatic lesion was identified.
  • (1) The prevalence of pancreatic neoplasms and (2) performance characteristics of EUS-FNA for identifying malignant neoplasm, in this patient group.
  • RESULTS: In 110 study patients, the final diagnosis included adenocarcinoma (n = 7), pancreatic intraepithelial neoplasia (n = 1), neuroendocrine tumor (n = 1), tumor metastasis (n = 1), and benign cyst (n = 3).
  • Thirty-two patients had EUS evidence of chronic pancreatitis, and, in the remaining 65 patients, the pancreas was normal.
  • The accuracy of EUS and EUS-FNA for diagnosing pancreatic neoplasm in these patients was 99.1%, with 88.8% sensitivity, 100% specificity, 99% negative predicative value, and 100% positive predictive value.
  • CONCLUSION: A pancreatic neoplasm is seen in a clinically significant number of patients with "enlarged HOP" or "dilated PD with or without a dilated CBD" but without obstructive jaundice.
  • EUS-FNA seems highly accurate for diagnosing pancreatic neoplasm in these patients.
  • [MeSH-major] Adenocarcinoma / diagnosis. Biopsy, Fine-Needle / methods. Diagnostic Imaging / methods. Endosonography / methods. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Age Distribution. Aged. Cohort Studies. Common Bile Duct / pathology. Common Bile Duct / ultrasonography. Female. Humans. Immunohistochemistry. Incidence. Magnetic Resonance Imaging / methods. Male. Middle Aged. Pancreatic Ducts / pathology. Pancreatic Ducts / ultrasonography. Pancreatitis / diagnosis. Pancreatitis / epidemiology. Prognosis. Retrospective Studies. Risk Factors. Sensitivity and Specificity. Sex Distribution. Survival Analysis. Tomography, X-Ray Computed / methods

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  • [CommentIn] Endoscopy. 2010 Jan;42(1):68-72 [20066593.001]
  • (PMID = 18423464.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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80. Sparks DA, Chase DM, Forsyth M, Bogen G, Arnott J: Late presentation of a mucinous ovarian adenocarcinoma which was initially diagnosed as a primary pancreatic carcinoma: a case report and review of the literature. J Med Case Rep; 2010;4:90
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  • [Title] Late presentation of a mucinous ovarian adenocarcinoma which was initially diagnosed as a primary pancreatic carcinoma: a case report and review of the literature.
  • INTRODUCTION: Adenocarcinoma of the ovary is an aggressive neoplasm which often metastasizes to the lung or liver.
  • Metastases rarely occur to the pancreas, but a tissue diagnosis is required to confirm this event.
  • Although most tumors of the pancreas are primary pancreatic neoplasms, metastatic lesions have been reported most commonly as arising from renal cell carcinoma.
  • CASE PRESENTATION: We report the case of a 51-year-old Caucasian woman with ovarian mucinous adenocarcinoma with metastasis to the head of the pancreas that was originally misdiagnosed as a pancreatic primary tumor.
  • CONCLUSION: Mucinous ovarian adenocarcinomas rarely metastasize to the pancreas.
  • New pancreatic lesions should be investigated through tissue biopsy and tumor markers, while keeping an open-minded differential diagnosis to avoid a misdiagnosis or a delay in treatment.

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  • (PMID = 20298585.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
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81. Naitoh H, Shoji H, Ishikawa I, Watanabe R, Furuta Y, Tomozawa S, Igarashi H, Shinozaki S, Katsura H, Onozato R, Kudoh M: Intraductal papillary mucinous tumor of the pancreas associated with autosomal dominant polycystic kidney disease. J Gastrointest Surg; 2005 Jul-Aug;9(6):843-5
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  • [Title] Intraductal papillary mucinous tumor of the pancreas associated with autosomal dominant polycystic kidney disease.
  • CT showed multiple cysts in the liver and both kidneys along with ADPKD and a cystic mass, 4 cm in diameter, in the pancreatic head.
  • The main pancreatic duct was dilated to 1 cm in diameter.
  • Histologic examination revealed a multiloculated cystic tumor filled with mucin in the head of the pancreas.
  • Microscopically, the tumor was diagnosed as adenocarcinoma and was found to have invaded the main pancreatic duct.
  • Although, in addition to our case, only seven cases with association between ADPKD and malignant neoplasms have been reported, five of these cases had neoplasms arising from the pancreas.
  • Therefore, we suggest that some genetic interactions may exist between ADPKD and pancreatic carcinogenesis.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Carcinoma, Pancreatic Ductal / diagnosis. Pancreatic Neoplasms / diagnosis. Pancreaticoduodenectomy / methods. Polycystic Kidney, Autosomal Dominant / diagnosis
  • [MeSH-minor] Abdominal Pain / diagnosis. Abdominal Pain / etiology. Acute Disease. Adult. Biopsy, Needle. Follow-Up Studies. Humans. Immunohistochemistry. Male. Pancreatitis / diagnosis. Pancreatitis / etiology. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome


82. Thayalasekaran S, Liddicoat H, Wood E: Thrombophlebitis migrans in a man with pancreatic adenocarcinoma: a case report. Cases J; 2009;2:6610
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  • [Title] Thrombophlebitis migrans in a man with pancreatic adenocarcinoma: a case report.
  • It is an acquired coagulopathy that is strongly associated with malignancy, especially solid tumours of the adenocarcinoma type.
  • Ultrasound demonstrated a mass in the head of the pancreas causing common bile duct obstruction.
  • Histology confirmed pancreatic adenocarcinoma.
  • CONCLUSION: Thrombophlebitis migrans is more easily recognised in patients with an established diagnosis of malignancy than in situations where the thrombophlebitis is first diagnosed.

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  • (PMID = 19829832.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2709970
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83. Schima W, Ba-Ssalamah A, Plank C, Kulinna-Cosentini C, Prokesch R, Tribl B, Sautner T, Niederle B: [Pancreas. Part II: Tumors]. Radiologe; 2006 May;46(5):421-37; quiz 438
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  • [Title] [Pancreas. Part II: Tumors].
  • Adenocarcinoma is the most common malignant pancreatic tumor, affecting the head in 60-70% of cases.
  • By the time of diagnosis, approximately 80% of tumors are unresectable.
  • Helical CT is very effective in detection and staging of adenocarcinoma, with a sensitivity of 76-92% for detection and an accuracy of 80-90% for staging, but it has limitations in the detection of small cancers (< or =2 cm).
  • Gadolinium-enhanced 3D gradient-echo MRI is helpful in the assessment of vascular invasion of cancer and in determining the etiology of cystic lesions.
  • Diagnosis of insulinoma is a challenge: they are <2 cm in 90% of cases and mostly hypervascular at CT or MRI.
  • This review summarizes the imaging features of the most common pancreatic tumors and discusses the limitations of CT, MRI and endosonography.
  • [MeSH-major] Adenocarcinoma / diagnosis. Magnetic Resonance Imaging / methods. Pancreatic Neoplasms / diagnosis. Tomography, X-Ray Computed / methods. Ultrasonography / methods

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  • (PMID = 16715226.001).
  • [ISSN] 0033-832X
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 66
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84. Sugiyama Y, Tanno S, Nishikawa T, Nakamura K, Sasajima J, Koizumi K, Mizukami Y, Karasaki H, Kasai S, Yoshida Y, Watanabe N, Okumura T, Kohgo Y: [A case of pancreatic carcinoma presenting as pancreaticopleural fistula with pancreatic pleural effusion]. Nihon Shokakibyo Gakkai Zasshi; 2010 May;107(5):784-91
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  • [Title] [A case of pancreatic carcinoma presenting as pancreaticopleural fistula with pancreatic pleural effusion].
  • A diagnosis of pancreaticopleural fistula was made, based on the findings of magnetic resonance cholangiopancreatography and endoscopic retrograde pancreatography (ERP).
  • After the placement of an endoscopic naso-pancreatic drainage tube, the pleural effusion markedly reduced.
  • When ERP was performed for internal drainage, the main pancreatic duct and stricture were biopsied and showed pancreatic ductal adenocarcinoma histologically.
  • CT revealed a mass in the head of the pancreas.
  • To the best of our knowledge this is the first case of pancreatic carcinoma presenting as pancreaticopleural fistula with pancreatic pleural effusion.
  • Clinicians should pay attention to the possible presence of cancer and pancreaticopleural fistula in patients with pancreatic pleural effusion.
  • [MeSH-major] Adenocarcinoma / diagnosis. Fistula / diagnosis. Pancreatic Fistula / diagnosis. Pancreatic Neoplasms / diagnosis. Pleural Diseases / diagnosis. Pleural Effusion / complications
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 20460853.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 17
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85. Ho Kim D, Shiozawa S, Tsuchiya A, Usui T, Inose S, Aizawa M, Yoshimatsu K, Katsube T, Naritaka Y, Ogawa K: [A case of drug-induced interstitial pneumonitis after adjuvant chemotherapy with gemcitabine for pancreatic cancer]. Gan To Kagaku Ryoho; 2008 Jan;35(1):133-6
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  • [Title] [A case of drug-induced interstitial pneumonitis after adjuvant chemotherapy with gemcitabine for pancreatic cancer].
  • The patient was a 48-year-old male who underwent pancreaticoduodenectomy with portal vein resection for ductal adenocarcinoma of the pancreas head.
  • [MeSH-major] Deoxycytidine / analogs & derivatives. Lung Diseases, Interstitial / complications. Pancreatic Neoplasms / drug therapy

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  • (PMID = 18195543.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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86. Ohtsubo K, Watanabe H, Okada G, Tsuchiyama T, Mouri H, Yamaguchi Y, Motoo Y, Okai T, Amaya K, Kitagawa H, Ohta T, Gabata T, Matsuda K, Ohta H, Sawabu N: A case of pancreatic cancer with formation of a mass mimicking alcoholic or autoimmune pancreatitis in a young man. Possibility of diagnosis by hypermethylation of pure pancreatic juice. JOP; 2008;9(1):37-45
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  • [Title] A case of pancreatic cancer with formation of a mass mimicking alcoholic or autoimmune pancreatitis in a young man. Possibility of diagnosis by hypermethylation of pure pancreatic juice.
  • There have been some cases of an ambiguous diagnosis although care was taken to differentiate between alcoholic mass-forming pancreatitis, focal type autoimmune pancreatitis and pancreatic cancer.
  • CASE REPORT: We report a case of pancreatic cancer mimicking alcoholic or autoimmune pancreatitis with the formation of a mass in a 32-year-old man with a history of heavy drinking.
  • After he stopped drinking, abdominal computed tomography showed a pancreatic head mass 28 mm in diameter with little and weak enhancement in the early and delayed phases, respectively.
  • Endoscopic retrograde cholangiopancreatography showed an obstruction of the main pancreatic duct in the pancreatic head and marked stenosis of the lower common bile duct.
  • Although a percutaneous ultrasound-guided pancreatic biopsy demonstrated no evidence of autoimmune pancreatitis, he was treated with prednisolone to test the efficacy of steroid therapy.
  • However, the pancreatic mass became enlarged after steroid therapy, and he underwent surgery during which the mass was found to be pancreatic cancer.
  • We retrospectively assessed DNA hypermethylation in the patient's pure pancreatic juice obtained on admission.
  • We observed hypermethylation of the cancer-specific gene tissue factor pathway inhibitor 2 (TFPI2).
  • CONCLUSION: This finding suggests that if the DNA hypermethylation of pure pancreatic juice had been assayed before steroid therapy, it would have supported the diagnosis of pancreatic cancer, and steroid therapy could have been avoided.
  • [MeSH-major] Adenocarcinoma / diagnosis. Autoimmune Diseases / diagnosis. DNA Methylation. Pancreatic Juice / physiology. Pancreatic Neoplasms / diagnosis. Pancreatitis, Alcoholic / diagnosis
  • [MeSH-minor] Adult. Biopsy. Cholangiopancreatography, Endoscopic Retrograde. Diagnosis, Differential. Fatal Outcome. Glycoproteins / genetics. Humans. Male. Ultrasonography


87. Okada K, Furuuchi T, Tamada T, Sasaki T, Suwa T, Shatari T, Takenaka Y, Hori M, Sakuma M: Pancreatobiliary fistula associated with an intraductal papillary-mucinous pancreatic neoplasm manifesting as obstructive jaundice: report of a case. Surg Today; 2008;38(4):371-6
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  • [Title] Pancreatobiliary fistula associated with an intraductal papillary-mucinous pancreatic neoplasm manifesting as obstructive jaundice: report of a case.
  • We report a pancreatobiliary fistula caused by an intraductal papillary-mucinous pancreatic neoplasm (IPMN), manifesting as obstructive jaundice.
  • Computed tomography showed dilatation of the bile duct and main pancreatic duct, with multiple cystic masses in the head of the pancreas.
  • Pancreatogram and magnetic resonance cholangiopancreatography showed diffuse dilatation of the main pancreatic duct and side branches without communication with the adjacent organs or duct.
  • We performed pancreaticoduodenectomy for IPMN of the pancreatic head and a tumor-like lesion in the lower common bile duct (CBD).
  • Macroscopically, impacted thick mucus protruded into the CBD from the pancreas via a pancreatobiliary fistula.
  • Histologic examination revealed a pancreatobiliary fistula caused by intraductal papillary-mucinous carcinoma of the pancreas with mucin hypersecretion, an adenoma without interstitial infiltration, and isolated implantation of an IPMN in the bile duct mucosa around the fistula.
  • [MeSH-major] Adenocarcinoma, Mucinous / complications. Biliary Fistula / complications. Carcinoma, Papillary / complications. Jaundice, Obstructive / etiology. Pancreatic Fistula / complications. Pancreatic Neoplasms / complications. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Aged. Cholangiopancreatography, Endoscopic Retrograde. Diagnosis, Differential. Follow-Up Studies. Humans. Male

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  • (PMID = 18368332.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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88. Funamizu N, Aramaki M, Matsumoto T, Inomata M, Shibata K, Himeno Y, Yada K, Hirano S, Sasaki A, Kawano K, Kitano S: Groove pancreatic carcinoma. Hepatogastroenterology; 2009 Nov-Dec;56(96):1742-4
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  • [Title] Groove pancreatic carcinoma.
  • The groove area is localized between the head of the pancreas, the duodenum, and the common bile duct.
  • Differentiating of groove pancreatitis from pancreatic carcinoma is often difficult.
  • Herein, we report a 54-year-old woman with groove pancreatic adenocarcinoma presenting epigastralgia, jaundice, and vomiting.
  • The diagnosis was confirmed by computed tomography (CT), endoscopic retrograde cholangiopancreatography (ERCP), and endoscopic biopsy.
  • Microscopically, well-differentiated adenocarcinoma was mainly located in Santorini's duct, but there was no invasion to the main pancreatic duct.
  • It is very difficult to differentiate groove pancreatic carcinoma from groove pancreatitis.
  • To avoid unnecessary surgical treatment, endoscopic biopsy and observation of the duodenum are useful for diagnosis.
  • However, keeping in mind the differential diagnosis of pancreatic head carcinoma is necessary.
  • [MeSH-major] Adenocarcinoma / diagnosis. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Pancreatitis, Chronic / diagnosis

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  • (PMID = 20214229.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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89. Fukushima N, Mukai K: [Pathologic characteristics and evaluation of the pancreatic cancer]. Gan To Kagaku Ryoho; 2005 May;32(5):599-604
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  • [Title] [Pathologic characteristics and evaluation of the pancreatic cancer].
  • Ductal adenocarcinoma is the most common tumor type of cancer of the pancreas.
  • It is generally a poorly demarcated, white to grey-solid tumor located in the pancreatic head.
  • Histologically, it is often well-to moderately-differentiated tubular adenocarcinoma along with marked desmoplastic change.
  • There are three well-defined precursors to invasive cancer; mucinous cystic neoplasms (MCNs), intraductal papillary mucinous neoplasms (IPMNs), and pancreatic intraepithelial neoplasia PanINs.
  • PanIN is now considered to be a precursor of pancreatic ductal adenocarcinoma based on molecular studies.
  • IPMNs and MCNs can form similar invasive carcinomas such as tubular adenocarcinoma and/or mucinous carcinoma.
  • Careful attention should be paid to the processes and/or criteria of pathologic diagnosis.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Pancreatic Ductal / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Mucinous / pathology. Cystadenocarcinoma, Mucinous / pathology. DNA-Binding Proteins / genetics. Diagnosis, Differential. Gene Expression Regulation, Neoplastic. Humans. Lymphatic Metastasis. Smad4 Protein. Trans-Activators / genetics

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  • (PMID = 15918557.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / SMAD4 protein, human; 0 / Smad4 Protein; 0 / Trans-Activators
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90. Calabrese L, Jereczek-Fossa BA, Jassem J, Rocca A, Bruschini R, Orecchia R, Chiesa F: Diagnosis and management of neck metastases from an unknown primary. Acta Otorhinolaryngol Ital; 2005 Feb;25(1):2-12
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  • [Title] Diagnosis and management of neck metastases from an unknown primary.
  • Metastases in the upper and middle neck (levels I-II-III-V) are generally attributed to head and neck cancers, whereas the lower neck (level IV) involvement is often associated with primaries below the clavicles.
  • Diagnostic procedures include a careful clinical evaluation and a fiberoptic endoscopic examination of the head and neck mucosa, biopsies from all suspicious sites or blindly from the sites of possible origin of the primary, computerized tomography scan, and magnetic resonance.
  • Thoracic, and abdominal primaries (especially from lung, oesophagus, stomach, ovary or pancreas) should be sought in the case of adenocarcinoma and involvement of the lower neck.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / secondary. Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / secondary. Neoplasms, Unknown Primary

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  • (PMID = 16080309.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 102
  • [Other-IDs] NLM/ PMC2639847
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91. Khan AZ, Miles WF, Singh KK: Initial experience with laparoscopic bypass for upper gastrointestinal malignancy: a new option for palliation of patients with advanced upper gastrointestinal tumors. J Laparoendosc Adv Surg Tech A; 2005 Aug;15(4):374-8
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  • PATIENTS AND METHODS: Between August 2000 and April 2002 laparoscopic gastric and biliary bypass concurrently or alone was attempted in 19 consecutive patients with unresectable carcinoma of the head of the pancreas, adenocarcinoma of the stomach, cholangiocarcinoma of the distal common bile duct, or adenocarcinoma of the duodenum.

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  • (PMID = 16108739.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. Benedix F, Lippert H, Meyer F: [Acute inguinal swelling--unusual presentation of postoperative necrotising pancreatitis]. Zentralbl Chir; 2009 Apr;134(2):186-8
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  • We report on a 61-year-old male who underwent explorative laparotomy for pancreatic tumour.
  • Intraoperatively, the diagnosis of a locally advanced carcinoma of the head of the pancreas was confirmed histologically.
  • [MeSH-major] Adenocarcinoma / surgery. Edema / surgery. Inguinal Canal / surgery. Pancreatic Neoplasms / surgery. Pancreatitis, Acute Necrotizing / surgery. Postoperative Complications / surgery
  • [MeSH-minor] Abdominal Abscess / diagnosis. Abdominal Abscess / pathology. Abdominal Abscess / surgery. Diagnosis, Differential. Hernia, Inguinal / diagnosis. Humans. Male. Middle Aged. Neoplasm Invasiveness. Reoperation


93. Yang YM, Wan YL, Tian XD, Zhuang Y, Huang YT: [Outcome of extended retroperitoneal lymphadenectomy in the surgical treatment of adenocarcinoma of the head of the pancreas]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2005 Oct;27(5):568-71
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  • [Title] [Outcome of extended retroperitoneal lymphadenectomy in the surgical treatment of adenocarcinoma of the head of the pancreas].
  • OBJECTIVE: To evaluate the clinical outcome of extended retroperitoneal lymphadenectomy as surgical therapy for adenocarcinoma of the head of the pancreas.
  • METHODS: Twenty patients with adenocarcinoma of the head of the pancreas were treated by standard pancreatoduodenectomy (standard group) between 1994 and 1997, and 46 patients with the same disease underwent extended retroperitoneal lymphadenectomy associated with standard pancreatoduodenectomy (radical group) between 1998 and 2002.
  • Of the 46 patients in the radical group, 26.09% (12/46) had metastatic adenocarcinoma in the resected retroperitoneal lymph nodes.
  • [MeSH-major] Adenocarcinoma / surgery. Lymph Node Excision / methods. Pancreatic Neoplasms / surgery

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  • (PMID = 16274033.001).
  • [ISSN] 1000-503X
  • [Journal-full-title] Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
  • [ISO-abbreviation] Zhongguo Yi Xue Ke Xue Yuan Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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94. Bakouboula B, Morel O, Douchet MP, Chauvin M: [Reversible cardiogenic shock under 5-fluorouracil treatment]. Ann Cardiol Angeiol (Paris); 2005 Aug;54(4):216-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • 5-fluorouracil, an antimetabolite agent, has been widely used since 1957 for treatment of varied types of cancer such as gastro-intestinal, pancreas, breast, lung, head and neck malignancies.
  • The following clinical case represents a potentially serious and rare case of completely reversible cardiogenic shock in a patient with a colo-rectal cancer.
  • A better knowledge of these complications could reduce cases of death by an earlier diagnosis, and a better evaluation of patients with high cardiotoxicity risk.
  • [MeSH-minor] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / adverse effects. Cardiotonic Agents / therapeutic use. Colorectal Neoplasms / drug therapy. Dobutamine / therapeutic use. Dopamine / therapeutic use. Humans. Male. Middle Aged

  • Hazardous Substances Data Bank. FLUOROURACIL .
  • Hazardous Substances Data Bank. DOPAMINE .
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  • (PMID = 16104623.001).
  • [ISSN] 0003-3928
  • [Journal-full-title] Annales de cardiologie et d'angéiologie
  • [ISO-abbreviation] Ann Cardiol Angeiol (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Cardiotonic Agents; 3S12J47372 / Dobutamine; U3P01618RT / Fluorouracil; VTD58H1Z2X / Dopamine
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95. Cameron JL, Riall TS, Coleman J, Belcher KA: One thousand consecutive pancreaticoduodenectomies. Ann Surg; 2006 Jul;244(1):10-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • SUMMARY BACKGROUND DATA: A regional resection of the head of the pancreas was first performed successfully by Kausch in 1909.
  • A total of 405 patients underwent pancreaticoduodenectomy for adenocarcinoma of the head of the pancreas.
  • It has become an effective operation for pancreatic cancer in those patients in whom their tumor is margin negative and node negative.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Pancreatic Neoplasms / mortality. Pancreatic Neoplasms / surgery. Postoperative Complications. Survival Rate

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