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6. Stipa F, Alessandroni L, Cimitan A, Burza A, Cavallotti C, Cavallini M, Tersigni R, Ziparo V: [Pancreaticoduodenectomy for adenocarcinoma of the pancreatic head and papilla of Vater]. Minerva Chir; 2009 Aug;64(4):395-406
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  • [Title] [Pancreaticoduodenectomy for adenocarcinoma of the pancreatic head and papilla of Vater].
  • [Transliterated title] Duodenocefalopancreatectomia per adenocarcinoma della testa del pancreas e della papilla di Vater.
  • AIM: The authors report their consecutive experience in the surgical management of adenocarcinoma (ADC) of head of pancreas and papilla of Vater, in order to review the available literature.
  • METHODS: One hundred and seventy cases (131 in the head of pancreas and 39 in the papilla of Vater) were operated upon for ADC by radical pancreaticoduodenectomy in the period 1972-2005.
  • RESULTS: Postoperative morbidity was reported in 66 patients (38.8%) and pancreatic fistulae were observed in 39 patients (22.9%).
  • Five-year survival for pancreatic ADC was 75% in stage IA, 43.9% in stage IB and IIA, 3.2% in stage IIB.
  • The Wirsung duct has to be anastomosed directly to the jejunum and the pancreatic section needs to be checked.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Neoplasms, Multiple Primary / surgery. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy

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  • (PMID = 19648859.001).
  • [ISSN] 0026-4733
  • [Journal-full-title] Minerva chirurgica
  • [ISO-abbreviation] Minerva Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 79
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7. Matsubayashi H, Matsunaga K, Uesaka K, Fukutomi A, Sasaki K, Furukawa H, Ono H: A case of pancreatic carcinoma with suspected autoimmune pancreatitis. Clin J Gastroenterol; 2009 Feb;2(1):59-63
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  • [Title] A case of pancreatic carcinoma with suspected autoimmune pancreatitis.
  • We present a case of pancreatic carcinoma with strongly suspected coexisting autoimmune pancreatitis (AIP).
  • The patient presented with a chief complaint of icterus and weight loss, and was referred to our institution after a pancreatic lesion was found.
  • Ultrasonography demonstrated an enlarged pancreas with smooth borders and low internal echo density.
  • Enhanced computed tomography (CT) showed a sausage-shaped pancreas without definitive metastasis to the surrounding lymph nodes and liver.
  • Imaging of the pancreatic duct, including endoscopic retrograde pancreatography (ERP) and magnetic resonance cholangiopancreatography (MRCP), showed stenosis of the main pancreatic duct at the pancreatic head as well as a long segment of narrowing at the body and no dilatation at the tail.
  • Tissues from these stenotic sites and open biopsy from pancreatic body showed infiltrating adenocarcinoma and dense fibrosis.
  • To date, only a small number of reports have described pancreatic carcinoma accompanied with AIP.
  • It is important to confirm diagnosis with histology in cases of suspicious autoimmune pancreatitis, even when the clinical images are compatible with AIP.

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  • (PMID = 26191812.001).
  • [ISSN] 1865-7257
  • [Journal-full-title] Clinical journal of gastroenterology
  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Auto-antibody / Autoimmune pancreatitis / IgG4 / Pancreatic carcinoma
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8. Heinrich S, Goerres GW, Schäfer M, Sagmeister M, Bauerfeind P, Pestalozzi BC, Hany TF, von Schulthess GK, Clavien PA: Positron emission tomography/computed tomography influences on the management of resectable pancreatic cancer and its cost-effectiveness. Ann Surg; 2005 Aug;242(2):235-43
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  • [Title] Positron emission tomography/computed tomography influences on the management of resectable pancreatic cancer and its cost-effectiveness.
  • OBJECTIVE: We sought to determine the impact of positron emission tomography/computed tomography (PET/CT) on the management of presumed resectable pancreatic cancer and to assess the cost of this new staging procedure.
  • SUMMARY BACKGROUND DATA: PET using 18F-fluorodeoxyglucose (FDG) is increasingly used for the staging of pancreatic cancer, but anatomic information is limited.
  • MATERIAL AND METHODS: Patients with suspected pancreatic cancer who had a PET/CT between June 2001 to April 2004 were entered into a prospective database.
  • Cost benefit analysis was performed based on charged cost of PET/CT and pancreatic resection and included the time frame of staging and surgery.
  • Fifty-one patients had lesions in the head and 8 in the tail of the pancreas.
  • The positive and negative predictive values for pancreatic cancer were 91% and 64%, respectively.
  • PET/CT detected additional distant metastases in 5 and synchronous rectal cancer in 2 patients.
  • PET/CT findings changed the management in 16% of patients with pancreatic cancer deemed resectable after routine staging (P = 0.031) and was cost saving.
  • CONCLUSIONS: PET/CT represents an important staging procedure prior to pancreatic resection for cancer, since it significantly improves patient selection and is cost-effective.
  • [MeSH-major] Adenocarcinoma / diagnosis. Pancreatic Neoplasms / diagnosis. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 16041214.001).
  • [ISSN] 0003-4932
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Other-IDs] NLM/ PMC1357729
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9. Pine JK, Fusai KG, Young R, Sharma D, Davidson BR, Menon KV, Rahman SH: Serum C-reactive protein concentration and the prognosis of ductal adenocarcinoma of the head of pancreas. Eur J Surg Oncol; 2009 Jun;35(6):605-10
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  • [Title] Serum C-reactive protein concentration and the prognosis of ductal adenocarcinoma of the head of pancreas.
  • BACKGROUND: The prognostic role of serum C-reactive protein in pancreatic cancer has received increasing attention; however the confounding effects of biliary obstruction have not been addressed in previous studies.
  • We sought to determine the prognostic importance of serum CRP prior to biliary intervention in the prognosis of pancreatic adenocarcinoma.
  • METHODS: A retrospective case note review of patients diagnosed with pancreatic cancer between 2001 and 2006.
  • CONCLUSION: Raised serum C-reactive protein concentration at the time of presentation of advanced pancreatic cancer carries a poor prognosis independent of biliary tract obstruction.
  • [MeSH-major] C-Reactive Protein / analysis. Carcinoma, Pancreatic Ductal / blood. Pancreatic Neoplasms / blood

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  • (PMID = 19128923.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 9007-41-4 / C-Reactive Protein
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10. Tanaka H, Takamori H, Eto S, Ozaki N, Akaboshi S, Nakahara O, Ida S, Furuhashi S, Abe S, Horino K, Beppu T, Baba H: [Acute liver injury with hepatic encephalopathy associated with gemcitabine administration for adjuvant chemotherapy in an HBV carrier with pancreatic cancer]. Gan To Kagaku Ryoho; 2010 Sep;37(9):1783-6
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  • [Title] [Acute liver injury with hepatic encephalopathy associated with gemcitabine administration for adjuvant chemotherapy in an HBV carrier with pancreatic cancer].
  • Imagings revealed cancer of the head of the pancreas.
  • We performed pancreaticoduodenectomy for pancreatic cancer.
  • The histopathological diagnosis was tubular adenocarcinoma of the pancreas.
  • [MeSH-major] Deoxycytidine / analogs & derivatives. Hepatic Encephalopathy / chemically induced. Hepatitis B / complications. Liver / injuries. Pancreatic Neoplasms / drug therapy


11. Alibegov RA, Prokhorenko TI, Sergeev OA, Khlusov AN: [The long term results and survival prognostic factors of surgical treatment ampulla Vateri cancer]. Khirurgiia (Mosk); 2008;(4):27-30
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  • [Title] [The long term results and survival prognostic factors of surgical treatment ampulla Vateri cancer].
  • Results of radical operative treatment of 21 patients with ampulla Vateri cancer are presented.
  • Factors having prognostic value for survival rate are the stage of disease, metastatic regional spread, tumor invasion in a head of a pancreas, microscopic picture of a pancreatitis in a phase of acute condition.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / mortality. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy / methods

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  • (PMID = 18454104.001).
  • [ISSN] 0023-1207
  • [Journal-full-title] Khirurgiia
  • [ISO-abbreviation] Khirurgiia (Mosk)
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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12. Matsubara N, Baba H, Okamoto A, Kurata M, Tsuruta K, Funata N, Ashizawa K: Rectal cancer metastasis to the head of the pancreas treated with pancreaticoduodenectomy. J Hepatobiliary Pancreat Surg; 2007;14(6):590-4
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  • [Title] Rectal cancer metastasis to the head of the pancreas treated with pancreaticoduodenectomy.
  • We report a case of a 50-year-old man who developed metastatic pancreatic cancer from a primary rectal cancer that had been curatively removed 3 years previously.
  • The patient presented with a tumor that occupied the head of the pancreas, associated with obstructive jaundice, but the main pancreatic duct was not dilated.
  • The patient was initially diagnosed as having primary pancreatic cancer.
  • Cytological examination of the bile was conclusive for the presence of adenocarcinoma.
  • For 1 year, local disease progression was slow and no distant metastases developed; therefore, the initial diagnosis of pancreatic cancer was questioned.
  • On histology, including immunohistochemical staining for cytokeratin 20 (positive) and cytokeratin 7 (negative), the tumor was shown to be a metastatic pancreatic carcinoma that had originated from the original rectal cancer.
  • [MeSH-major] Pancreatic Neoplasms / secondary. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy. Rectal Neoplasms / pathology
  • [MeSH-minor] Angiography. Cholangiopancreatography, Magnetic Resonance. Diagnosis, Differential. Fatal Outcome. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 18040627.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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13. Koizumi M, Sata N, Shimura K, Tsukahara M, Yoshizawa K, Kurihara K, Hyodo M, Yasuda Y, Nagai H: [An outpatient with unresectable pancreatic cancer treated with gemcitabine showing prolonged NC (22 months)]. Gan To Kagaku Ryoho; 2005 Dec;32(13):2133-6
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  • [Title] [An outpatient with unresectable pancreatic cancer treated with gemcitabine showing prolonged NC (22 months)].
  • A 3 cm tumor was found in the head of the pancreas by abdominal CT, and the patient underwent laparotomy.
  • The tumor was histologically diagnosed as a well-differentiated adenocarcinoma, and showed extensive invasion to the portal vein (T4NXM 0 Stage IV a).
  • Here we report a case of unresectable pancreatic cancer treated with gemcitabine on the basis of a drug sensitivity test.
  • [MeSH-major] Adenocarcinoma / drug therapy. Ambulatory Care. Antimetabolites, Antineoplastic / therapeutic use. Deoxycytidine / analogs & derivatives. Pancreatic Neoplasms / drug therapy

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  • (PMID = 16352944.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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4. Kitagawa H, Ohta T, Makino I, Tani T, Tajima H, Nakagawara H, Ohnishi I, Takamura H, Kayahara M, Watanabe H, Gabata T, Matsui O, Zen Y: Carcinomas of the ventral and dorsal pancreas exhibit different patterns of lymphatic spread. Front Biosci; 2008;13:2728-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinomas of the ventral and dorsal pancreas exhibit different patterns of lymphatic spread.
  • In patients with carcinoma of the head of the pancreas with positive lymph nodes, the extent of an adequate lymph node dissection beyond peripancreatic area has remained controversial.
  • Based on the two anlagens, the ventral or dorsal pancreas, we assessed the lymphatic spread pattern in 58 primary adenocarcinoma of head of the pancreas.
  • When the tumor was confined to the ventral pancreas domain (n=20), the lymph node metastases were limited to areas along the superior mesenteric artery (SMA) besides peripancreatic lymph nodes.
  • When the tumor was in the dorsal pancreas domain (n=6), the lymph node metastases were limited to areas along the common hepatic artery (CHA) and the hepatoduodenal ligament besides peripancreatic lymph nodes.
  • Based on these findings, the lymphatic spread of carcinomas of the head of the pancreas can be divided into two patterns by tumor location based on the two anlagens of the pancreas.
  • [MeSH-major] Carcinoma / pathology. Gene Expression Regulation, Neoplastic. Lymphatic Metastasis. Pancreas / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 17981748.001).
  • [ISSN] 1093-9946
  • [Journal-full-title] Frontiers in bioscience : a journal and virtual library
  • [ISO-abbreviation] Front. Biosci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Bachireddy P, Tseng D, Horoschak M, Chang DT, Koong AC, Kapp DS, Tran PT: Orthovoltage intraoperative radiation therapy for pancreatic adenocarcinoma. Radiat Oncol; 2010;5:105
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  • [Title] Orthovoltage intraoperative radiation therapy for pancreatic adenocarcinoma.
  • PURPOSE: To analyze the outcomes of patients from a single institution treated with surgery and orthovoltage intraoperative radiotherapy (IORT) for pancreatic adenocarcinoma.
  • Most tumors were located in the head of the pancreas (83%) and sites irradiated included: tumor bed (57%), vessels (26%), both the tumor bed/vessels (13%) and other (4%).
  • However, distant metastases remain the major problem for patients with pancreatic adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Pancreatic Neoplasms / radiotherapy. Radiotherapy / methods

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  • (PMID = 21059255.001).
  • [ISSN] 1748-717X
  • [Journal-full-title] Radiation oncology (London, England)
  • [ISO-abbreviation] Radiat Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2987939
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16. Obana T, Fujita N, Noda Y, Kobayashi G, Ito K, Horaguchi J, Takasawa O, Tsuchiya T, Sawai T: Small pancreatic cancer with pancreas divisum preoperatively diagnosed by pancreatic juice cytology. Intern Med; 2009;48(18):1661-6
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  • [Title] Small pancreatic cancer with pancreas divisum preoperatively diagnosed by pancreatic juice cytology.
  • We present a case of small pancreatic head cancer with pancreas divisum preoperatively diagnosed by pancreatic juice cytology.
  • A 60-year-old woman was referred to our hospital for evaluation of a dilated main pancreatic duct (MPD).
  • A small and poorly reproducible low-echoic lesion in the pancreas was suspected by ultrasonography (US) and endoscopic ultrasonography (EUS).
  • Magnetic resonance cholangiopancreatography (MRCP) failed to visualize the ventral pancreatic duct, and the upstream dorsal pancreatic duct was dilated.
  • Endoscopic retrograde cholangiopancreatography (ERCP) was indicative of pancreas divisum, and complete obstruction of the MPD in the pancreatic head was seen.
  • Cytology of pancreatic juice obtained from the dorsal pancreas after minor papilla sphincterotomy revealed the presence of adenocarcinoma cells.
  • Pancreatoduodenectomy was performed under the diagnosis of pancreatic head cancer with pancreas divisum.
  • Histological examination revealed moderately-differentiated tubular adenocarcinoma 20 mm in diameter, located in the pancreatic head.
  • Dilatation of the dorsal pancreatic duct is sometimes observed in cases with pancreas divisum without the presence of tumors.
  • When pancreatic duct stenosis also exists in such cases, even if a tumor is not clearly visualized by diagnostic imaging, vigorous examinations such as pancreatic juice cytology are recommended to establish an accurate diagnosis.
  • [MeSH-major] Pancreas / abnormalities. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenocarcinoma / ultrasonography. Cholangiopancreatography, Endoscopic Retrograde. Female. Humans. Middle Aged. Pancreatic Juice / cytology

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  • (PMID = 19755770.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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17. Calabrese L, Jereczek-Fossa BA, Jassem J, Rocca A, Bruschini R, Orecchia R, Chiesa F: Diagnosis and management of neck metastases from an unknown primary. Acta Otorhinolaryngol Ital; 2005 Feb;25(1):2-12
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  • [Title] Diagnosis and management of neck metastases from an unknown primary.
  • Metastases in the upper and middle neck (levels I-II-III-V) are generally attributed to head and neck cancers, whereas the lower neck (level IV) involvement is often associated with primaries below the clavicles.
  • Diagnostic procedures include a careful clinical evaluation and a fiberoptic endoscopic examination of the head and neck mucosa, biopsies from all suspicious sites or blindly from the sites of possible origin of the primary, computerized tomography scan, and magnetic resonance.
  • Thoracic, and abdominal primaries (especially from lung, oesophagus, stomach, ovary or pancreas) should be sought in the case of adenocarcinoma and involvement of the lower neck.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / secondary. Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / secondary. Neoplasms, Unknown Primary

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  • (PMID = 16080309.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 102
  • [Other-IDs] NLM/ PMC2639847
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18. Koizumi K, Fujii T, Matsumoto A, Sugiyama R, Suzuki S, Sukegawa R, Ozawa K, Orii F, Taruishi M, Saitoh Y, Sotokawa M, Takada A: [Synchronous double invasive ductal carcinomas of the pancreas with multifocal branch duct intraductal papillary mucinous neoplasms of the pancreas]. Nihon Shokakibyo Gakkai Zasshi; 2009 Jan;106(1):98-105
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  • [Title] [Synchronous double invasive ductal carcinomas of the pancreas with multifocal branch duct intraductal papillary mucinous neoplasms of the pancreas].
  • A 52-year-old man with a history of distal gastrectomy for gastric cancer was admitted to our hospital because of jaundice.
  • CT scan revealed double tumors in the pancreatic head and body concomitant with multicystic lesions of the pancreas.
  • Final histological diagnosis was double invasive ductal carcinomas of the pancreas head and tail with multifocal branch duct intraductal papillary mucinous adenomas of the pancreas.
  • The present case suggests that entire pancreas might have malignant potential in patients with intraductal papillary mucinous neoplasms.
  • [MeSH-major] Adenocarcinoma, Mucinous / surgery. Carcinoma, Pancreatic Ductal / surgery. Carcinoma, Papillary / surgery. Neoplasms, Multiple Primary. Pancreatic Neoplasms / surgery

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  • (PMID = 19122428.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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19. Seelig MH, Chromik AM, Weyhe D, Müller CA, Belyaev O, Mittelkötter U, Tannapfel A, Uhl W: Pancreatic redo procedures: to do or not to do -- this is the question. J Gastrointest Surg; 2007 Sep;11(9):1175-82
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  • [Title] Pancreatic redo procedures: to do or not to do -- this is the question.
  • BACKGROUND: Pancreatic redo procedures belong to the most difficult abdominal operations because of altered anatomy, significant adhesions, and the potential of recurrent disease.
  • We report on our experience with 15 redo procedures among a series of 350 consecutive pancreatic operations.
  • PATIENT AND METHODS: From January 1, 2004 to May 31, 2006 a total of 350 patients underwent pancreatic surgery in our department.
  • There were 15 patients identified who had pancreatic redo surgery for benign (14) or malignant (1) disease.
  • Perioperative parameters and outcome of 15 patients undergoing redo surgery after pancreatic resections were evaluated.
  • RESULTS: Operative procedures included revision and redo of the pancreaticojejunostomy after resection of the pancreatic margin (6), completion pancreatectomy (3), conversion from duodenum-preserving pancreatic head resection to pylorus-preserving pancreaticoduodenectomy (3), classic pancreaticoduodenectomy after nonresective pancreatic surgery (1), redo of left-sided pancreatectomy (1), and classic pancreaticoduodenectomy after left-sided pancreatectomy (1).
  • Histology revealed chronic pancreatitis in 14 and a mucinous adenocarcinoma of the pancreas in 1 patient.
  • CONCLUSION: Pancreatic redo surgery can be performed with low morbidity and mortality.
  • [MeSH-major] Digestive System Surgical Procedures. Pancreatic Neoplasms / surgery. Pancreatitis, Chronic / surgery
  • [MeSH-minor] Adult. Constriction, Pathologic. Cystadenocarcinoma / surgery. Female. Gastroenterostomy. Humans. Jejunum / pathology. Magnetic Resonance Imaging. Male. Middle Aged. Pancreatic Ducts / pathology. Pancreaticoduodenectomy. Pancreaticojejunostomy. Reoperation

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  • (PMID = 17588191.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Miura T, Igarashi Y, Okano N, Miki K, Okubo Y: Endoscopic diagnosis of intraductal papillary-mucinous neoplasm of the pancreas by means of peroral pancreatoscopy using a small-diameter videoscope and narrow-band imaging. Dig Endosc; 2010 Apr;22(2):119-23
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  • [Title] Endoscopic diagnosis of intraductal papillary-mucinous neoplasm of the pancreas by means of peroral pancreatoscopy using a small-diameter videoscope and narrow-band imaging.
  • BACKGROUND: Intraductal papillary-mucinous neoplasm (IPMN) is an intraductal tumor in which the mucin-producing epithelium shows proliferated papillary and a wide variety of pathological changes ranging from hyperplasia to adenocarcinoma.
  • We carried out the differential diagnosis of benign lesion to malignant lesion.
  • METHODS: Between April 2003 and May 2009, PPS using a small-diameter videoscope by means of NBI was carried out on 21 hospitalized patients with IPMN (10 cases of adenocarcinoma, 11 cases of adenoma or hyperplasia; 14 males and seven females, with a mean age of 69.4 years).
  • RESULTS: Fifteen focal lesions of the 16 cases in the head of the pancreas (93.7%) and four focal lesions of the five cases in the pancreatic body (80%) were observable, whereas two lesions (adenocarcinoma in the pancreatic body, and adenoma in the uncus of pancreas) were not observable.
  • Endoscopically, seven cases were classified as villous type and two cases as vegetative type, and nine cases were diagnosed as adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma / diagnosis. Endoscopes. Endoscopy, Digestive System / instrumentation. Pancreatic Ducts. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Equipment Design. Female. Humans. Hyperplasia / diagnosis. Male

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  • (PMID = 20447205.001).
  • [ISSN] 1443-1661
  • [Journal-full-title] Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
  • [ISO-abbreviation] Dig Endosc
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] Australia
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21. M'sakni I, Rammeh S, Chelbi E, Sayari S, Zaouech A, Baltagi-Ben Jilani S, Zermani R: [Adenocarcinoma and gastro-intestinal stromal tumor: fortuitous association or a single carcinogenic agent? A report of 2 cases]. Ann Chir; 2006 Oct;131(8):464-7
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  • [Title] [Adenocarcinoma and gastro-intestinal stromal tumor: fortuitous association or a single carcinogenic agent? A report of 2 cases].
  • One is of a 44-year-old man presenting a high grade gastric stromal tumor associated with an adenocarcinoma of the large bowel.
  • The other is of a 68-year-old man presenting an adenocarcinoma of the head of the pancreas associated with a low grade gastric stromal tumor.
  • The hypothesis that the association is due to a simple coincidence particularly in areas with high rates of digestive cancer is proposed.
  • [MeSH-major] Adenocarcinoma. Colonic Neoplasms. Gastrointestinal Stromal Tumors. Neoplasms, Multiple Primary. Pancreatic Neoplasms
  • [MeSH-minor] Adult. Colectomy. Colon / pathology. Colonoscopy. Humans. Male. Middle Aged. Pancreas / pathology. Radiography, Abdominal. Tomography, X-Ray Computed

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  • (PMID = 16527243.001).
  • [ISSN] 0003-3944
  • [Journal-full-title] Annales de chirurgie
  • [ISO-abbreviation] Ann Chir
  • [Language] fre
  • [Publication-type] Case Reports; Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
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22. Kuroki T, Tajima Y, Tsutsumi R, Mishima T, Kitasato A, Adachi T, Kanematsu T: Inferior branch-preserving superior head resection of the pancreas with gastric wall-covering method for intraductal papillary mucinous adenoma. Am J Surg; 2006 Jun;191(6):823-6
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  • [Title] Inferior branch-preserving superior head resection of the pancreas with gastric wall-covering method for intraductal papillary mucinous adenoma.
  • Intraductal papillary mucinous neoplasm (IPMN) of the pancreas showed significantly less aggressive pathologic features compared with common pancreatic cancer.
  • Therefore, several organ-preserving techniques, including duodenum-preserving pancreatic head resection, have been advocated in surgical procedures for IPMN.
  • We describe a surgical technique of superior head resection of the pancreas with inferior branch preservation followed by a gastric wall-covering method for the prevention of pancreatic leakage in patients with IPMN of the pancreas head.
  • [MeSH-major] Adenocarcinoma, Mucinous / surgery. Carcinoma, Pancreatic Ductal / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / surgery. Stomach / surgery
  • [MeSH-minor] Abdominal Pain / diagnosis. Abdominal Pain / etiology. Aged. Anastomosis, Surgical. Cholangiopancreatography, Endoscopic Retrograde / methods. Follow-Up Studies. Humans. Immunohistochemistry. Male. Neoplasm Staging. Risk Assessment. Treatment Outcome

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  • (PMID = 16720158.001).
  • [ISSN] 0002-9610
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Schima W, Ba-Ssalamah A, Plank C, Kulinna-Cosentini C, Prokesch R, Tribl B, Sautner T, Niederle B: [Pancreas. Part II: Tumors]. Radiologe; 2006 May;46(5):421-37; quiz 438
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  • [Title] [Pancreas. Part II: Tumors].
  • Adenocarcinoma is the most common malignant pancreatic tumor, affecting the head in 60-70% of cases.
  • By the time of diagnosis, approximately 80% of tumors are unresectable.
  • Helical CT is very effective in detection and staging of adenocarcinoma, with a sensitivity of 76-92% for detection and an accuracy of 80-90% for staging, but it has limitations in the detection of small cancers (< or =2 cm).
  • Gadolinium-enhanced 3D gradient-echo MRI is helpful in the assessment of vascular invasion of cancer and in determining the etiology of cystic lesions.
  • Diagnosis of insulinoma is a challenge: they are <2 cm in 90% of cases and mostly hypervascular at CT or MRI.
  • This review summarizes the imaging features of the most common pancreatic tumors and discusses the limitations of CT, MRI and endosonography.
  • [MeSH-major] Adenocarcinoma / diagnosis. Magnetic Resonance Imaging / methods. Pancreatic Neoplasms / diagnosis. Tomography, X-Ray Computed / methods. Ultrasonography / methods

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  • (PMID = 16715226.001).
  • [ISSN] 0033-832X
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 66
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24. Alwaheeb S, Chetty R: Adenosquamous carcinoma of the pancreas with an acantholytic pattern together with osteoclast-like and pleomorphic giant cells. J Clin Pathol; 2005 Sep;58(9):987-90
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  • [Title] Adenosquamous carcinoma of the pancreas with an acantholytic pattern together with osteoclast-like and pleomorphic giant cells.
  • Imaging of the abdomen showed a mass in the region of the head of the pancreas.
  • Histological evaluation of the pancreatic tumour showed an adenosquamous carcinoma (predominantly composed of squamous carcinoma), which was extensively infiltrative with perineural invasion and involvement of peripancreatic lymph nodes.
  • Areas of pancreatic intraepithelial neoplasia grade III and merging of the squamous and adenocarcinoma components were evident.
  • Although an acantholytic pattern has been noted in squamous carcinomas in other sites, this is the first report of such a pattern in an adenosquamous carcinoma of the pancreas.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Giant Cells / pathology. Osteoclasts / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 16126885.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1770836
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25. Lu B, Cai X, Lu W, Huang Y, Jin X: Laparoscopic pancreaticoduodenectomy to treat cancer of the ampulla of Vater. JSLS; 2006 Jan-Mar;10(1):97-100
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  • [Title] Laparoscopic pancreaticoduodenectomy to treat cancer of the ampulla of Vater.
  • Three patients had duodenal papillary cancer, one had cancer of the head of the pancreas, and one had pancreatic mixed cancer (duodenal papillary cancer, hepatobiliary ductal adenocarcinoma).
  • RESULTS: The pathology diagnosis was well-differentiated duodenum papillary adenocarcinoma in 3 patients, head of pancreas endocrine small cell carcinoma in 1, and duodenum papillary adenoma with malignancy ductal intermediate differentiation adenocarcinoma in 1.
  • After surgery, 1 patient had a small amount of pancreatic leakage, another developed stress ulcer bleeding; both patients became normal after appropriate treatment.

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  • (PMID = 16709370.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3015677
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26. Bersch VP, Osvaldt AB, Edelweiss MI, Schumacher Rde C, Wendt LR, Abreu LP, Blom CB, Abreu GP, Costa L, Piccinini P, Rohde L: Effect of nicotine and cigarette smoke on an experimental model of intraepithelial lesions and pancreatic adenocarcinoma induced by 7,12-dimethylbenzanthracene in mice. Pancreas; 2009 Jan;38(1):65-70
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  • [Title] Effect of nicotine and cigarette smoke on an experimental model of intraepithelial lesions and pancreatic adenocarcinoma induced by 7,12-dimethylbenzanthracene in mice.
  • OBJECTIVES: To evaluate the effects of nicotine and cigarette smoke exposure on mice submitted to 7,12-dimethylbenzanthracene (DMBA) model of pancreatic carcinogenesis.
  • At day 16, 1 mg of DMBA crystals was implanted in the pancreatic head of both groups.
  • The specimens were evaluated according to the following criteria: normal ducts, reactive hyperplasia, pancreatic intraepithelial neoplasm 3 (PanIN-3), and carcinoma.
  • Pancreatic adenocarcinoma has a higher frequency in the DMBA-n group (14 [51.9%]) than in the DMBA-e (4 [16.7%]) and DMBA-s (4, 13.3%) groups.
  • CONCLUSIONS: Nicotine but not cigarette smoke promotes pancreatic DMBA carcinogenesis in mice.
  • Pancreatic adenocarcinomas and PanINs have the same phenotypic appearance as those that occur in humans.
  • [MeSH-major] Adenocarcinoma / etiology. Carcinogens / toxicity. Carcinoma in Situ / etiology. Nicotine / toxicity. Pancreatic Neoplasms / etiology. Smoking / adverse effects

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  • (PMID = 18824948.001).
  • [ISSN] 1536-4828
  • [Journal-full-title] Pancreas
  • [ISO-abbreviation] Pancreas
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 57-97-6 / 9,10-Dimethyl-1,2-benzanthracene; 6M3C89ZY6R / Nicotine
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27. Mortelé KJ, Peters HE, Odze RD, Glickman JN, Jajoo K, Banks PA: An unusual mixed tumor of the pancreas: sonographic and MDCT features. JOP; 2009;10(2):204-8
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  • [Title] An unusual mixed tumor of the pancreas: sonographic and MDCT features.
  • CONTEXT: Mixed tumors of the pancreas are exceedingly rare.
  • CASE REPORT: We herein report on a 54-year-old female who presented with an enlarging cystic lesion in the head of the pancreas.
  • Right upper quadrant ultrasound and multidetector-row CT scan showed a well-defined unilocular cystic tumor located in the head of the pancreas and surrounded, in part, by a hypervascular solid mass.
  • CONCLUSION: Although mixed exocrine/endocrine pancreatic tumors have been described previously, to the best of our knowledge, this is the first case of a pancreatic mixed intraductal papillary mucinous neoplasm/endocrine tumor with illustration of its ultrasound and CT features.
  • Moreover, the importance of preoperative analysis of imaging features in the assessment of pancreatic neoplasms is discussed.
  • [MeSH-major] Mixed Tumor, Malignant / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Mucinous / metabolism. Adenocarcinoma, Mucinous / pathology. Carcinoma, Islet Cell / metabolism. Carcinoma, Islet Cell / pathology. Carcinoma, Pancreatic Ductal / metabolism. Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Papillary / metabolism. Carcinoma, Papillary / pathology. Female. Humans. Immunohistochemistry. Middle Aged. Mucin-2 / analysis. Pancreas / radiography. Pancreas / ultrasonography. Synaptophysin / analysis. Tomography, X-Ray Computed / methods. Ultrasonography / methods

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  • (PMID = 19287120.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / MUC2 protein, human; 0 / Mucin-2; 0 / Synaptophysin
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28. Adsay NV, Basturk O, Thirabanjasak D: Diagnostic features and differential diagnosis of autoimmune pancreatitis. Semin Diagn Pathol; 2005 Nov;22(4):309-17
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  • [Title] Diagnostic features and differential diagnosis of autoimmune pancreatitis.
  • In about 15% to 20% of patients, the clinical stigmata of autoimmune conditions are present at the time of diagnosis, and in many others, discovered subsequently.
  • Most patients present with a pancreatic head mass, often with an accompanying stricture of the distal common bile duct, which thus radiologically resembles "pancreas cancer."
  • Elevated serum IgG4 levels are characteristic and may be very helpful in the differential diagnosis from tumors and tumor-like lesions of the pancreas which seldom result in levels above 135 mg/dL.
  • [MeSH-major] Autoimmune Diseases / diagnosis. Pancreatitis / diagnosis
  • [MeSH-minor] Adenocarcinoma / pathology. Adrenal Cortex Hormones / therapeutic use. Adult. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 16939059.001).
  • [ISSN] 0740-2570
  • [Journal-full-title] Seminars in diagnostic pathology
  • [ISO-abbreviation] Semin Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones
  • [Number-of-references] 91
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29. Fujimori N, Nakamura T, Oono T, Igarashi H, Takahata S, Nakamura M, Tanaka M, Hayashi A, Aishima S, Ishigami K, Ogoshi K, Ito T, Takayanagi R: Adenocarcinoma involving the whole pancreas with multiple pancreatic masses. Intern Med; 2010;49(15):1527-32
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  • [Title] Adenocarcinoma involving the whole pancreas with multiple pancreatic masses.
  • A 77-year-old man was referred to our hospital for further investigation of pancreatic masses.
  • Imaging studies revealed hypovascular masses in the pancreatic head and body.
  • Total pancreatectomy was performed under the diagnosis of double primary pancreatic carcinomas.
  • Macroscopic examination revealed 3 nodules: one each in the pancreatic head, body, and tail.
  • Incidentally, we also identified an adenocarcinoma of the common bile duct (CBD).
  • The final diagnosis was synchronous double cancer involving the whole pancreas and the CBD.
  • [MeSH-major] Adenocarcinoma / diagnosis. Common Bile Duct Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Pancreatic Neoplasms / diagnosis

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  • (PMID = 20686284.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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30. Reyes-Gibby CC, Shete S, Yennurajalingam S, Frazier M, Bruera E, Kurzrock R, Crane CH, Abbruzzese J, Evans D, Spitz MR: Genetic and nongenetic covariates of pain severity in patients with adenocarcinoma of the pancreas: assessing the influence of cytokine genes. J Pain Symptom Manage; 2009 Dec;38(6):894-902
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  • [Title] Genetic and nongenetic covariates of pain severity in patients with adenocarcinoma of the pancreas: assessing the influence of cytokine genes.
  • We previously demonstrated that select cytokine gene polymorphisms in interleukin (IL)-8 are a significant predictor of pain and analgesia in patients with lung cancer.
  • This study explores the role of 13 potentially functional polymorphisms in cytokine genes, including IL-1beta, IL-6, IL-8, IL-10, IL-18, tumor necrosis factor-alpha, and nuclear factor kappa-B subunit 1, in pain severity in patients with pancreatic cancer.
  • We evaluated a series of patients with histologically confirmed adenocarcinoma of the pancreas (n=484), who had completed a self-administered survey of pain before initiating any cancer treatment.
  • We provide preliminary evidence of the role of IL-8 in the severity of pain in pancreatic cancer patients.

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  • (PMID = 19692203.001).
  • [ISSN] 1873-6513
  • [Journal-full-title] Journal of pain and symptom management
  • [ISO-abbreviation] J Pain Symptom Manage
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R03 CA128069; United States / NCI NIH HHS / CA / R03 CA128069-01A2; United States / NCI NIH HHS / CA / CA128069-01A2; United States / NCI NIH HHS / CA / K07 CA109043-05; United States / NCI NIH HHS / CA / CA109043-05; United States / NCI NIH HHS / CA / K07 CA109043; United States / NCI NIH HHS / CA / CA128069; United States / NCI NIH HHS / CA / P20 CA101936; United States / NCI NIH HHS / CA / CA101936; United States / NCI NIH HHS / CA / CA109043
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics; 0 / Cytokines
  • [Other-IDs] NLM/ NIHMS131146; NLM/ PMC2795073
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31. Fukumoto K, Suzuki S, Sakaguchi T, Morita Y, Oishi K, Suzuki A, Inaba K, Kamiya K, Miura K, Konno H: Adenocarcinoma arising from gastric duplication: a case report with literature review. Clin J Gastroenterol; 2008 Dec;1(4):148-152
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  • [Title] Adenocarcinoma arising from gastric duplication: a case report with literature review.
  • We report the case of a 50-year-old man with adenocarcinoma derived from gastric duplication.
  • Under the diagnosis of gastric duplication cysts, the oral cyst was removed with the gastric wall and the other cyst lesion firmly adhered to the bulbus was treated with distal gastrectomy.
  • Based on histological findings showing adenocarcinoma in the anal duplication cyst wall and regional lymph node metastases and cancer invasion into the duodenal stump, pancreatoduodenectomy was performed 9 days after the initial surgery.
  • Invasion into the pancreas head and duodenal walls was seen in the resected specimen.
  • This case report with literature review indicates that alimentary tract duplication cysts should be recognized as risky lesions of cancer development in patients aged 50 years or over.

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  • [Cites] Dig Dis Sci. 1996 Mar;41(3):627-9 [8617148.001]
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  • (PMID = 26193693.001).
  • [ISSN] 1865-7257
  • [Journal-full-title] Clinical journal of gastroenterology
  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Adenocarcinoma / Alimentary tract duplication / Cancer development / Gastric duplication cyst
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32. Casadei R, D'Ambra M, Freyrie A, Monari F, Alagna V, Ricci C, Minni F: Managing unsuspected tumour invasion of the superior mesenteric-portal vein during surgery for pancreatic head cancer. A case report. JOP; 2009;10(4):448-50
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  • [Title] Managing unsuspected tumour invasion of the superior mesenteric-portal vein during surgery for pancreatic head cancer. A case report.
  • CONTEXT: In some cases, synchronous superior mesenteric-portal vein resection can be performed during pancreatic resection for cancer.
  • CASE REPORT: We report a case of reconstruction of the superior mesenteric-portal vein with a splenic vein autograft in a patient affected by pancreatic head adenocarcinoma who underwent a total pancreatectomy.
  • [MeSH-major] Mesenteric Veins / surgery. Pancreatic Neoplasms / surgery. Portal Vein / surgery. Splenic Vein / transplantation

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  • (PMID = 19581755.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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33. Ohtsubo K, Watanabe H, Okada G, Tsuchiyama T, Mouri H, Yamaguchi Y, Motoo Y, Okai T, Amaya K, Kitagawa H, Ohta T, Gabata T, Matsuda K, Ohta H, Sawabu N: A case of pancreatic cancer with formation of a mass mimicking alcoholic or autoimmune pancreatitis in a young man. Possibility of diagnosis by hypermethylation of pure pancreatic juice. JOP; 2008;9(1):37-45
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  • [Title] A case of pancreatic cancer with formation of a mass mimicking alcoholic or autoimmune pancreatitis in a young man. Possibility of diagnosis by hypermethylation of pure pancreatic juice.
  • There have been some cases of an ambiguous diagnosis although care was taken to differentiate between alcoholic mass-forming pancreatitis, focal type autoimmune pancreatitis and pancreatic cancer.
  • CASE REPORT: We report a case of pancreatic cancer mimicking alcoholic or autoimmune pancreatitis with the formation of a mass in a 32-year-old man with a history of heavy drinking.
  • After he stopped drinking, abdominal computed tomography showed a pancreatic head mass 28 mm in diameter with little and weak enhancement in the early and delayed phases, respectively.
  • Endoscopic retrograde cholangiopancreatography showed an obstruction of the main pancreatic duct in the pancreatic head and marked stenosis of the lower common bile duct.
  • Although a percutaneous ultrasound-guided pancreatic biopsy demonstrated no evidence of autoimmune pancreatitis, he was treated with prednisolone to test the efficacy of steroid therapy.
  • However, the pancreatic mass became enlarged after steroid therapy, and he underwent surgery during which the mass was found to be pancreatic cancer.
  • We retrospectively assessed DNA hypermethylation in the patient's pure pancreatic juice obtained on admission.
  • We observed hypermethylation of the cancer-specific gene tissue factor pathway inhibitor 2 (TFPI2).
  • CONCLUSION: This finding suggests that if the DNA hypermethylation of pure pancreatic juice had been assayed before steroid therapy, it would have supported the diagnosis of pancreatic cancer, and steroid therapy could have been avoided.
  • [MeSH-major] Adenocarcinoma / diagnosis. Autoimmune Diseases / diagnosis. DNA Methylation. Pancreatic Juice / physiology. Pancreatic Neoplasms / diagnosis. Pancreatitis, Alcoholic / diagnosis
  • [MeSH-minor] Adult. Biopsy. Cholangiopancreatography, Endoscopic Retrograde. Diagnosis, Differential. Fatal Outcome. Glycoproteins / genetics. Humans. Male. Ultrasonography


34. Bloomston M, Chanona-Vilchis J, Ellison EC, Ramirez NC, Frankel WL: Carcinosarcoma of the pancreas arising in a mucinous cystic neoplasm. Am Surg; 2006 Apr;72(4):351-5
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  • [Title] Carcinosarcoma of the pancreas arising in a mucinous cystic neoplasm.
  • We report a carcinosarcoma of the pancreas in a 67-year-old woman who presented with nausea, vomiting, and painless jaundice.
  • A work-up demonstrated a well-circumscribed mass in the head of the pancreas.
  • After pylorus-preserving pancreaticoduodenectomy, the tumor was found to be grossly yellow, and it compressed the common bile duct and pancreatic duct.
  • To the best of our knowledge, this is the second case of carcinosarcoma with invasive epithelial and sarcomatous areas in the background of a mucinous cystic neoplasm of the pancreas.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinosarcoma / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 16676863.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Hadjicostas P, Malakounides N, Varianos C, Kitiris E, Lerni F, Symeonides P: Radiofrequency ablation in pancreatic cancer. HPB (Oxford); 2006;8(1):61-4
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  • [Title] Radiofrequency ablation in pancreatic cancer.
  • The radiofrequency destruction of solid pancreatic tumors sounds logical but also seems risky due to the friable pancreatic parenchyma, the fear of pancreatitis and the prejudiced myth of 'the pancreas is not your friend'.
  • PATIENTS AND METHODS: We present our initial experience and we describe our technique during intraoperative RFA in four patients with locally advanced and unresectable pancreatic adenocarcinoma (head of pancreas, three; body-tail, one; diameter, 3-12 cm).
  • In one patient (with cancer of the body of the pancreas) who was receiving morphine because of intolerable pain, significant pain relief has been observed.
  • CONCLUSIONS: From our initial results, RFA seems to be a feasible, potentially safe and promising option in patients with locally advanced and unresectable pancreatic cancer.

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  • (PMID = 18333241.001).
  • [ISSN] 1365-182X
  • [Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association
  • [ISO-abbreviation] HPB (Oxford)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2131369
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36. Chatelain D, Vibert E, Yzet T, Geslin G, Bartoli E, Manaouil D, Delcenserie R, Brevet M, Dupas JL, Regimbeau JM: Groove pancreatitis and pancreatic heterotopia in the minor duodenal papilla. Pancreas; 2005 May;30(4):e92-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Groove pancreatitis and pancreatic heterotopia in the minor duodenal papilla.
  • Groove pancreatitis is a rare form of segmental chronic pancreatitis that involves the anatomic space between the head of the pancreas, the duodenum, and the common bile duct.
  • We report 2 cases of groove pancreatitis with pancreatic heterotopia in the minor papilla.
  • Abdominal computed tomography revealed thickening of the duodenal wall and enlargement of the pancreatic head in both patients.
  • In 1 patient, ultrasound endoscopy showed a dilated duct in the head of the pancreas.
  • Pancreaticoduodenectomy was performed to rule out pancreatic adenocarcinoma and because of the severity of the symptoms.
  • In both cases, there were microscopic foci of heterotopic pancreas with mild fibrosis in the wall of the minor papilla.
  • The pathogenesis of this rare entity could be because of disturbance of the pancreatic secretion through the minor papilla.
  • Pancreatitis in heterotopic pancreas located in the minor papilla and chronic consumption of alcohol seem to be important pathogenic factors.
  • [MeSH-major] Choristoma. Duodenal Diseases / pathology. Pancreas. Pancreatic Ducts / pathology. Pancreatitis, Chronic / pathology


37. Hsu JT, Yeh CN, Chen YR, Chen HM, Hwang TL, Jan YY, Chen MF: Adenosquamous carcinoma of the pancreas. Digestion; 2005;72(2-3):104-8
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  • [Title] Adenosquamous carcinoma of the pancreas.
  • BACKGROUND/AIMS: Adenosquamous carcinoma (ASC) of the pancreas is rare and correct preoperative diagnosis is difficult.
  • Case reports of ASC of the pancreas are sporadic and have typically employed small series.
  • This study investigated the clinicopathological features of 7 cases of ASC of the pancreas and reviewed the pertinent literature to elucidate this rare disease.
  • METHODOLOGY: Seven patients (4 men and 3 women; age range 38-79 years; median 66 years) with ASC of the pancreas who underwent surgical treatment at Chang Gung Memorial Hospital between February 1993 and April 2000 were retrospectively reviewed.
  • The tumors were located at the head of the pancreas in 4 patients (57.1%), at the body in 2, and at the tail in 2.
  • CONCLUSIONS: Patients with ASC present symptoms similar to those of adenocarcinoma of the pancreas.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Pancreatic Neoplasms / pathology

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  • [Copyright] Copyright (c) 2005 S. Karger AG, Basel.
  • (PMID = 16172546.001).
  • [ISSN] 0012-2823
  • [Journal-full-title] Digestion
  • [ISO-abbreviation] Digestion
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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38. Delpero JR, Turrini O: [Ductal adenocarcinoma of the head of the pancreas: a critical study of R1 resection rates]. Bull Cancer; 2008 Dec;95(12):1193-8
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  • [Title] [Ductal adenocarcinoma of the head of the pancreas: a critical study of R1 resection rates].
  • Complete resection (R0) remains the only potentially curative treatment of ductal adenocarcinoma of the pancreas.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Pancreatic Ductal / surgery. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Humans. Neoadjuvant Therapy. Neoplasm Recurrence, Local. Neoplasm, Residual. Pancreas / pathology. Pancreas / surgery. Pancreatectomy. Prognosis

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  • (PMID = 19091653.001).
  • [ISSN] 1769-6917
  • [Journal-full-title] Bulletin du cancer
  • [ISO-abbreviation] Bull Cancer
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 29
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39. Takahashi S, Homma H, Akiyama T, Mesawa S, Hirata K, Kogawa K, Takanashi K, Ishiwatari H, Kawano Y, Hayashi T, Takada K, Miyanishi K, Kato J, Niitsu Y: [A case of intraductal papillary mucinous neoplasm with internal pancreatic fistula causing left ureteral obstruction]. Nihon Shokakibyo Gakkai Zasshi; 2007 Aug;104(8):1236-44
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  • [Title] [A case of intraductal papillary mucinous neoplasm with internal pancreatic fistula causing left ureteral obstruction].
  • A 75-year-old man had been admitted to another hospital because of left abdominal pain, and was given a diagnosis of left hydronephrosis and acute pancreatitis.
  • US and EUS revealed a chronic pancreatitis-like pattern and multicystic lesion in the pancreas head and body.
  • At that time enhanced CT findings showed an extrapancreatic low density area to be inflammatory change, extending from the pancreas body to the left crus of the diaphragm and posteriorly the spreading from the left crus of the diaphragm via the left urinary duct into the left iliopsoas muscle, in which MRI revealed partial high intensity.
  • ERCP and MRCP showed focal irregular narrowing of the pancreatic duct of unknown cause, and we decided that an internal pancreatic fistula due to pancreatitis had induced left ureteral obstruction, caused by a protein plug or alcohol.
  • [MeSH-major] Adenocarcinoma, Mucinous / complications. Carcinoma, Pancreatic Ductal / complications. Pancreatic Fistula / complications. Pancreatic Neoplasms / complications. Ureteral Obstruction / etiology

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  • (PMID = 17675827.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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40. Ellsmere J, Mortele K, Sahani D, Maher M, Cantisani V, Wells W, Brooks D, Rattner D: Does multidetector-row CT eliminate the role of diagnostic laparoscopy in assessing the resectability of pancreatic head adenocarcinoma? Surg Endosc; 2005 Mar;19(3):369-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Does multidetector-row CT eliminate the role of diagnostic laparoscopy in assessing the resectability of pancreatic head adenocarcinoma?
  • BACKGROUND: We hypothesized that the high-quality images from multidetector-row computed tomography (MDCT) would lead to improved sensitivity and specificity for predicting resectable pancreatic head adenocarcinoma, thus diminishing the value of staging laparoscopy.
  • CONCLUSIONS: Despite the improvements in image quality obtained with multidetector-row technology, CT imaging remains a relatively nonspecific test for predicting resectability in patients with adenocarcinoma of the head of the pancreas.
  • Minimally invasive modalities with higher specificity, particularly laparoscopy, continue to have an important role in staging pancreatic head adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Laparoscopy. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / surgery. Tomography, X-Ray Computed

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  • (PMID = 15624058.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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41. Freelove R, Walling AD: Pancreatic cancer: diagnosis and management. Am Fam Physician; 2006 Feb 1;73(3):485-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pancreatic cancer: diagnosis and management.
  • Although only 32,000 new cases of adenocarcinoma of the pancreas occur in the United States each year, it is the fourth leading cause of cancer deaths in this country.
  • Risk factors include smoking, certain familial cancer syndromes, and familial chronic pancreatitis.
  • The link between risk of pancreatic cancer and other factors (e.g., diabetes, obesity) is less clear.
  • Most patients present with obstructive jaundice caused by compression of the bile duct in the head of the pancreas.
  • Epigastric or back pain, vague abdominal symptoms, and weight loss also are characteristic of pancreatic cancer.
  • More than one half of cases have distant metastasis at diagnosis.
  • The majority of tumors are not surgically resectable because of metastasis and invasion of the major vessels posterior to the pancreas.
  • [MeSH-major] Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / therapy

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  • (PMID = 16477897.001).
  • [ISSN] 0002-838X
  • [Journal-full-title] American family physician
  • [ISO-abbreviation] Am Fam Physician
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 51
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42. Lin PW, Shan YS, Lin YJ, Hung CJ: Pancreaticoduodenectomy for pancreatic head cancer: PPPD versus Whipple procedure. Hepatogastroenterology; 2005 Sep-Oct;52(65):1601-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pancreaticoduodenectomy for pancreatic head cancer: PPPD versus Whipple procedure.
  • BACKGROUND/AIMS: Resectable carcinoma of the head of the pancreas can be treated with either standard (the Whipple) or pylorus-preserving pancreaticoduodenectomy (PPPD).
  • METHODOLOGY: From July 1994 to Oct 2002, a prospective randomized comparison between the Whipple procedure and PPPD done by the same surgeon for the patients with carcinoma of the head of the pancreas was conducted.
  • Thirty-six patients diagnosed as pancreatic head adenocarcinoma were randomized to receive either the Whipple procedure or a PPPD.
  • CONCLUSIONS: There was no significant difference between the Whipple procedure and PPPD for the treatment of pancreatic head cancer in terms of operating time, blood loss, operative mortality and long-term survival.
  • [MeSH-major] Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / methods

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  • (PMID = 16201125.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Randomized Controlled Trial
  • [Publication-country] Greece
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43. Ray B, New NE, Wedgwood KR: Clear cell carcinoma of exocrine pancreas: a rare tumor with an unusual presentation. Pancreas; 2005 Mar;30(2):184-5
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  • [Title] Clear cell carcinoma of exocrine pancreas: a rare tumor with an unusual presentation.
  • Metastatic clear cell carcinomas are relatively common from primary tumors arising in the kidney, female genital tract, adrenal cortex, and lung, but they rarely occur from primary tumors of the pancreas.
  • We report a case of metastatic pancreatic tumor with marked clear cell changes in a 46-year-old white man presenting with a pseudocyst of the pancreas.
  • At laparotomy, there was a hard area in the head of the pancreas and another hard nodule was present in the omentum.
  • The histologic and immunohistochemical test of the excised omental nodule exhibited features consistent with clear cell carcinoma from pancreatic primary.
  • To our knowledge, this is the first report of a metastatic clear cell pancreatic tumor with such an unusual presentation.
  • [MeSH-major] Adenocarcinoma, Clear Cell / secondary. Omentum / pathology. Pancreas, Exocrine / pathology. Pancreatic Neoplasms / pathology. Pancreatic Pseudocyst / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 15714142.001).
  • [ISSN] 1536-4828
  • [Journal-full-title] Pancreas
  • [ISO-abbreviation] Pancreas
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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44. Ruiz-Tovar J, Martín-Pérez E, Gamallo-Amat C: Distal cholangiocarcinoma associated with papillitis with viral CMV inclusions. Dig Surg; 2005;22(6):464-6
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  • At laparotomy, dilatation of the bile ducts and an enlarged head of the pancreas were found.
  • Histological analysis revealed moderately differentiated ductal adenocarcinoma of the distal bile tract.
  • [MeSH-major] Bile Duct Neoplasms / complications. Bile Ducts, Intrahepatic. Cholangiocarcinoma / complications. Cytomegalovirus Infections / complications. Pancreatic Ducts

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  • [Copyright] Copyright (c) 2005 S. Karger AG, Basel.
  • (PMID = 16549927.001).
  • [ISSN] 0253-4886
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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45. Grenacher L, Klauss M: [Computed tomography of pancreatic tumors]. Radiologe; 2009 Feb;49(2):107-23
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  • [Title] [Computed tomography of pancreatic tumors].
  • Computed tomography (CT) and in particular multi-detector row computed tomography (MDCT), also known as multislice CT (MSCT), is ideally suited for detecting pancreatic tumors because of the high spatial resolution.The method of choice is hydro-CT which involves distension of the stomach and duodenum by administration of 1-1.5 l water as a negative contrast medium under medically induced hypotension by administration of buscopan.
  • The patient is laid on the right side at an angle of 30-45 degrees in order to obtain an artefact-free image of the close anatomical relationship around the pancreas head.
  • After the correct diagnosis of an adenocarcinoma has been made only 20% of all patients are shown to have a surgically resectable disease, but the overall survival rate is significantly higher after resection in combination with a multimodal tumor therapy strategy.
  • The reason is that the correct diagnosis of the resectability of the tumor is one of the main criteria for overall survival of these patients.
  • Currently practically all pancreatic tumors can be detected using MDCT and the detection rate varies between 70% and 100% (most recent literature references give a sensitivity of 89% and specificity up to 99%).
  • In some rare cases the differentiation between focal necrotizing pancreatitis and pancreatic carcinoma can be difficult even with sophisticated protocols.
  • MDCT is an ideal tool for the detection of neuroendocrine tumors, metastases and for the differentiation of cystic pancreatic lesions such as pseudocysts, microcystic adenomas or intraductal papillary mucinous neoplasms (IPMN).
  • Particularly, the differentiation of the latter into benign, borderline or malignant transformation is not always possible, but indirect signs, such as small nodules adjacent to the ductal wall, the diameter of the pancreatic duct, or a direct communication between cystic lesions and duct can be detected because of the high spatial resolution and is comparable to the findings in MRI.
  • [MeSH-major] Image Processing, Computer-Assisted. Imaging, Three-Dimensional. Pancreatic Neoplasms / diagnostic imaging. Tomography, Spiral Computed
  • [MeSH-minor] Adenocarcinoma / diagnostic imaging. Adenocarcinoma / mortality. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adenocarcinoma, Mucinous / diagnostic imaging. Adenocarcinoma, Mucinous / mortality. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / surgery. Carcinoma, Pancreatic Ductal / diagnostic imaging. Carcinoma, Pancreatic Ductal / mortality. Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Pancreatic Ductal / surgery. Carcinoma, Papillary / diagnostic imaging. Carcinoma, Papillary / mortality. Carcinoma, Papillary / pathology. Carcinoma, Papillary / surgery. Diagnosis, Differential. Disease-Free Survival. Humans. Neuroendocrine Tumors / diagnostic imaging. Neuroendocrine Tumors / mortality. Neuroendocrine Tumors / pathology. Neuroendocrine Tumors / surgery. Pancreas / diagnostic imaging. Pancreas / pathology. Pancreatectomy. Pancreatic Pseudocyst / diagnostic imaging. Prognosis. Sensitivity and Specificity

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  • [ISSN] 1432-2102
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] Journal Article; Review
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  • [Number-of-references] 71
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46. Takamatsu S, Ban D, Irie T, Noguchi N, Kudoh A, Nakamura N, Kawamura T, Igari T, Teramoto K, Arii S: Resection of a cancer developing in the remnant pancreas after a pancreaticoduodenectomy for pancreas head cancer. J Gastrointest Surg; 2005 Feb;9(2):263-9
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  • [Title] Resection of a cancer developing in the remnant pancreas after a pancreaticoduodenectomy for pancreas head cancer.
  • We report a rare case of a curative resection performed on a carcinoma developing in the remnant pancreas at 3 years 7 months after a pancreaticoduodenectomy for pancreatic cancer.
  • A 63-year-old man underwent a pancreaticoduodenectomy for pancreatic cancer on November 1999.
  • In May 2003, tumor marker levels increased, and a tumor was detected in the remnant pancreas on computed tomography.
  • There were no findings such as invasion into the surrounding tissue or distant metastasis, and therefore we removed the remnant pancreas in July 2003.
  • Histopathologically, the tumor consisted of a well-differentiated tubular adenocarcinoma and was limited to the pancreas.
  • Moreover, the anastomotic site of the pancreaticojejunostomy was negative for cancer, and some foci of papillary hyperplasia and goblet cell metaplasia of the pancreatic ductal epithelium, which was thought to be the precursor of the pancreatic cancer, were seen.
  • These findings suggested that the tumor was a second primary cancer developing in the remnant pancreas.
  • This case provided suggestive evidence for the development of pancreatic cancer, and the surgical procedure for a pancreaticoduodenectomy with occlusion of the celiac trunk is discussed.
  • [MeSH-major] Adenocarcinoma / surgery. Neoplasm, Residual / surgery. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy
  • [MeSH-minor] Anastomosis, Surgical. Dilatation, Pathologic. Humans. Male. Middle Aged. Pancreatic Ducts / pathology. Tomography, X-Ray Computed

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  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
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47. Pickartz T, Mayerle J, Kraft M, Evert M, Evert K, Kühn JP, Heidecke CD, Lerch MM: [Chronic pancreatitis as a risk factor for the development of pancreatic cancer--diagnostic challenges]. Med Klin (Munich); 2010 Apr;105(4):281-5
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  • [Title] [Chronic pancreatitis as a risk factor for the development of pancreatic cancer--diagnostic challenges].
  • Patients with chronic pancreatitis are burdened with an increased risk of developing pancreatic cancer.
  • Strategies or guidelines for the surveillance and early detection of pancreatic adenocarcinoma in patients with chronic pancreatitis are not established, because available clinical, serologic or imaging techniques are still of limited sensitivity and specificity.
  • Despite these limitations do patients with chronic pancreatitis and suspected pancreatic cancer need a careful and sometimes repeated diagnostic work-up.
  • A clear benefit of surveillance programs outside of clinical trials for the early detection of pancreatic cancer has not been demonstrated.
  • A 51-year-old patient with chronic pancreatitis is reported who developed cancer of the pancreatic head while undergoing repeated imaging studies.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / diagnosis. Pancreatic Neoplasms / diagnosis. Pancreatitis, Alcoholic / diagnosis
  • [MeSH-minor] Anastomosis, Roux-en-Y. Disease Progression. Early Diagnosis. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Pancreas / pathology. Pancreatectomy. Tomography, X-Ray Computed. Ultrasonography

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  • [ISSN] 1615-6722
  • [Journal-full-title] Medizinische Klinik (Munich, Germany : 1983)
  • [ISO-abbreviation] Med. Klin. (Munich)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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48. de Castro SM, de Nes LC, Nio CY, Velseboer DC, ten Kate FJ, Busch OR, van Gulik TM, Gouma DJ: Incidence and characteristics of chronic and lymphoplasmacytic sclerosing pancreatitis in patients scheduled to undergo a pancreatoduodenectomy. HPB (Oxford); 2010 Feb;12(1):15-21
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  • BACKGROUND: The determination of the exact nature of a pancreatic head mass in a patient scheduled to undergo a pancreatoduodenectomy can be very difficult.
  • The aim of the present study was to analyse the incidence of pancreatitis and the signs and symptoms associated with these tumours mistaken for pancreatic cancer and the diagnostic procedures performed.
  • METHODS: A consecutive group of patients who underwent a pancreatoduodenectomy between 1992 and 2005 with histopathologically proven pancreatic adenocarcinoma (PCA) and pancreatitis were analysed.
  • Pancreatic adenocarcinoma occurred in 227 patients (36%).
  • The determination of the exact nature of a pancreatic head mass remains difficult.
  • [MeSH-major] Adenocarcinoma / surgery. Autoimmune Diseases / surgery. Diagnostic Errors. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy. Pancreatitis, Chronic / surgery. Unnecessary Procedures

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  • (PMID = 20495640.001).
  • [ISSN] 1477-2574
  • [Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association
  • [ISO-abbreviation] HPB (Oxford)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2814399
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49. Zhu MH, Hu XG, Ni CR, Zhang SM, Xi PC, Yu GZ: [Mucinous noncystic (colloid) adenocarcinoma of the pancreas]. Zhonghua Bing Li Xue Za Zhi; 2005 Jul;34(7):389-92
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  • [Title] [Mucinous noncystic (colloid) adenocarcinoma of the pancreas].
  • OBJECTIVE: To determine the clinicopathologic characteristics and the relationship between related gene expression and pathobiologic behavior of pancreatic mucinous noncystic adenocarcinoma.
  • METHODS: Among the 249 pancreatic carcinoma cases from the department files, 6 tumors were identified to meet the pathologic criteria of colloid carcinoma.
  • RESULTS: In all 6 cases, the tumors were located in the head of the pancreas and all displayed similar microscopic findings.
  • CONCLUSIONS: Pancreatic mucinous noncystic adenocarcinoma has distinct morphologic features and biologic behavior.
  • Multiple gene products including many cyclins may be involved in the pathogenesis of pancreatic colloid carcinoma.
  • The tumor has an aggressive behavior with a high frequency of invasion and metastases, though the prognosis could be better than that of ordinary ductal adenocarcinoma of pancreas.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 16251039.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras)
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50. Schönleben F, Qiu W, Bruckman KC, Ciau NT, Li X, Lauerman MH, Frucht H, Chabot JA, Allendorf JD, Remotti HE, Su GH: BRAF and KRAS gene mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/IPMC) of the pancreas. Cancer Lett; 2007 May 8;249(2):242-8
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  • [Title] BRAF and KRAS gene mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/IPMC) of the pancreas.
  • Our study was performed to elucidate a possible role of BRAF in the development of IPMN (Intraductal Papillary Mucinous Neoplasm) and IPMC (Intraductal Papillary Mucinous Carcinoma) of the pancreas.

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  • (PMID = 17097223.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / K01 CA095434; United States / NCI NIH HHS / CA / R01 CA109525; United States / NCI NIH HHS / CA / CA95434; United States / NCI NIH HHS / CA / R01CA109525
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Ireland
  • [Chemical-registry-number] EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
  • [Other-IDs] NLM/ NIHMS16545; NLM/ PMC1865507
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51. Dumonceau JM, Vonlaufen A: Pancreatic endoscopic retrograde cholangiopancreatography (ERCP). Endoscopy; 2007 Feb;39(2):124-30
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  • [Title] Pancreatic endoscopic retrograde cholangiopancreatography (ERCP).
  • We review developments in five areas of therapeutic endoscopic retrograde cholangiopancreatography (ERCP) and management of pancreatic tumors during the period September 2005-August 2006.
  • First, in the management of painful chronic pancreatitis, the use of multiple plastic stents for aggressive dilation of strictures located in the head of the pancreas has been put forward to resolve two significant issues associated with current techniques, i. e., the requirement for numerous ERCPs for stent exchange and the high relapse rate after stent removal.
  • We then discuss the identification of protective factors against post-ERCP pancreatitis following pancreatic sphincterotomy.
  • Next, bearing in mind the prospect of increasing use of neoadjuvant chemotherapy for resectable pancreatic ductal adenocarcinoma, new evidence supporting the systematic use of self-expandable metal biliary stents before cancer staging is presented and critically considered.
  • Finally two centers with a high volume of cases have reported their experience with the drainage of pancreatic fluid collections with or without endosonography (EUS) guidance.
  • [MeSH-major] Cholangiopancreatography, Endoscopic Retrograde / methods. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / therapy. Pancreatitis / therapy. Stents
  • [MeSH-minor] Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / therapy. Carcinoma, Papillary / pathology. Carcinoma, Papillary / therapy. Chronic Disease. Drainage / methods. Humans. Pancreatic Ducts / pathology. Risk Factors. Sphincterotomy, Endoscopic

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  • (PMID = 17327971.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 23
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52. Okada K, Furuuchi T, Tamada T, Sasaki T, Suwa T, Shatari T, Takenaka Y, Hori M, Sakuma M: Pancreatobiliary fistula associated with an intraductal papillary-mucinous pancreatic neoplasm manifesting as obstructive jaundice: report of a case. Surg Today; 2008;38(4):371-6
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  • [Title] Pancreatobiliary fistula associated with an intraductal papillary-mucinous pancreatic neoplasm manifesting as obstructive jaundice: report of a case.
  • We report a pancreatobiliary fistula caused by an intraductal papillary-mucinous pancreatic neoplasm (IPMN), manifesting as obstructive jaundice.
  • Computed tomography showed dilatation of the bile duct and main pancreatic duct, with multiple cystic masses in the head of the pancreas.
  • Pancreatogram and magnetic resonance cholangiopancreatography showed diffuse dilatation of the main pancreatic duct and side branches without communication with the adjacent organs or duct.
  • We performed pancreaticoduodenectomy for IPMN of the pancreatic head and a tumor-like lesion in the lower common bile duct (CBD).
  • Macroscopically, impacted thick mucus protruded into the CBD from the pancreas via a pancreatobiliary fistula.
  • Histologic examination revealed a pancreatobiliary fistula caused by intraductal papillary-mucinous carcinoma of the pancreas with mucin hypersecretion, an adenoma without interstitial infiltration, and isolated implantation of an IPMN in the bile duct mucosa around the fistula.
  • [MeSH-major] Adenocarcinoma, Mucinous / complications. Biliary Fistula / complications. Carcinoma, Papillary / complications. Jaundice, Obstructive / etiology. Pancreatic Fistula / complications. Pancreatic Neoplasms / complications. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Aged. Cholangiopancreatography, Endoscopic Retrograde. Diagnosis, Differential. Follow-Up Studies. Humans. Male

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  • (PMID = 18368332.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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53. Yang YM, Wan YL, Tian XD, Zhuang Y, Huang YT: Outcome of pancreaticoduodenectomy with extended retroperitoneal lymphadenectomy for adenocarcinoma of the head of the pancreas. Chin Med J (Engl); 2005 Nov 20;118(22):1863-9
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  • [Title] Outcome of pancreaticoduodenectomy with extended retroperitoneal lymphadenectomy for adenocarcinoma of the head of the pancreas.
  • BACKGROUND: Nowadays, there is a remarkable rise in resectability rate of periampullary adenocarcinoma and the mortality and morbidity of the pancreaticoduodenectomy procedure have been reduced remarkably, while the 5 year survival rates of patients with carcinoma of the head of the pancreas are still below 25%.
  • We conducted this retrospective study to evaluate the clinical outcome of radical pancreaticoduodenectomy with extended retroperitoneal lymphadenectomy as a surgical therapy for adenocarcinoma of the head of the pancreas.
  • METHODS: Twenty cases with adenocarcinoma of the head of the pancreas were treated by standard pancreaticoduodenectomy (removing only the peripancreatic lymph nodes en bloc with the tumour) from 1994 to 1997, and 46 cases with the same disease underwent extended retroperitoneal lymphadenectomy associated with standard pancreaticoduodenectomy from 1998 to 2002.
  • Of the 46 cases in the radical group, 26% (12/46) had metastatic adenocarcinoma in the resected retroperitoneal lymph nodes.
  • [MeSH-major] Adenocarcinoma / surgery. Lymph Node Excision. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy

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  • (PMID = 16313840.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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54. Jin C, Yao L, Long J, Fu DL, Yu XJ, Xu J, Yang F, Ni QX: Effect of multiple-phase regional intra-arterial infusion chemotherapy on patients with resectable pancreatic head adenocarcinoma. Chin Med J (Engl); 2009 Feb 5;122(3):284-90
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  • [Title] Effect of multiple-phase regional intra-arterial infusion chemotherapy on patients with resectable pancreatic head adenocarcinoma.
  • BACKGROUND: Regional intra-arterial infusion chemotherapy (RIAC) has been more valuable to improve prognosis and quality of life of patients with inoperable pancreatic adenocarcinomas, and adjuvant RIAC plays an important role in prolonging survival and reducing risk of liver metastasis after radical resection of pancreatic cancer, but the effect of preoperative or multiple-phase RIAC (preoperative combined with postoperative RIAC) for resectable pancreatic cancers has not been investigated.
  • In this prospective study, the effect of multiple-phase RIAC for patients with resectable pancreatic head adenocarcinoma was evaluated, and its safety and validity comparing with postoperative RIAC were also assessed.
  • METHODS: Patients with resectable pancreatic head cancer were randomly assigned to two groups.
  • CONCLUSIONS: Multiple-phase RIAC is effective in combined therapy of resectable pancreatic head carcinomas by enhancing inhibition of tumor growth and reduction of liver metastasis, without negative effect on patients' safety or surgical procedure.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / surgery. Infusions, Intra-Arterial / methods. Pancreatic Neoplasms / drug therapy. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Deoxycytidine / analogs & derivatives. Deoxycytidine / therapeutic use. Disease-Free Survival. Female. Fluorouracil / therapeutic use. Humans. Liver Neoplasms / secondary. Male. Middle Aged. Mitomycin / therapeutic use. Neoplasm Metastasis. Pancreas / drug effects. Pancreas / pathology. Pancreas / surgery. Pancreaticoduodenectomy

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  • (PMID = 19236805.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; 50SG953SK6 / Mitomycin; B76N6SBZ8R / gemcitabine; U3P01618RT / Fluorouracil
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55. Turrini O, Viret F, Moureau-Zabotto L, Guiramand J, Moutardier V, Lelong B, de Chaisemartin C, Giovannini M, Delpero JR: Neoadjuvant 5 fluorouracil-cisplatin chemoradiation effect on survival in patients with resectable pancreatic head adenocarcinoma: a ten-year single institution experience. Oncology; 2009;76(6):413-9
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  • [Title] Neoadjuvant 5 fluorouracil-cisplatin chemoradiation effect on survival in patients with resectable pancreatic head adenocarcinoma: a ten-year single institution experience.
  • OBJECTIVES: It is the aim of this study to assess the outcome of patients who received neoadjuvant 5-fluorouracil-cisplatin chemoradiation (CRT) for stage I/III pancreatic adenocarcinoma.
  • RESULTS: Of the 102 patients enrolled in the study, 26 patients had progression of cancer during treatment and were deemed unresectable; 1 patient died during CRT of septic shock.
  • [MeSH-major] Adenocarcinoma / therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cisplatin / administration & dosage. Fluorouracil / administration & dosage. Pancreatic Neoplasms / therapy
  • [MeSH-minor] Disease-Free Survival. Follow-Up Studies. Humans. Neoadjuvant Therapy / methods. Pancreas / surgery. Recurrence. Time Factors. Treatment Outcome

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19407474.001).
  • [ISSN] 1423-0232
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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76. Nagino M, Nimura Y: [Dose "extended" surgery for pancreatic head adenocarcinoma have survival impact?]. Nihon Geka Gakkai Zasshi; 2006 Jul;107(4):173-6
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  • [Title] [Dose "extended" surgery for pancreatic head adenocarcinoma have survival impact?].
  • Adenocarcinoma of the pancreas is the most difficult to treat, and the prognosis, even if curative resection is possible, is dismal.
  • Two randomized controlled trials (RCTs) on "standard vs. extended surgery for pancreatic head adenocarcinoma" were reported in 1998 from Italy and in 2002 from USA.
  • We should therefore conclude that extended surgery does not improve survival for patients with pancreas head adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / surgery

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  • (PMID = 16878409.001).
  • [ISSN] 0301-4894
  • [Journal-full-title] Nihon Geka Gakkai zasshi
  • [ISO-abbreviation] Nihon Geka Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 14
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77. Zech CJ, Bruns C, Reiser MF, Herrmann KA: [Tumor-like lesion of the pancreas in chronic pancreatitis : imaging characteristics of computed tomography]. Radiologe; 2008 Aug;48(8):777-84
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  • [Title] [Tumor-like lesion of the pancreas in chronic pancreatitis : imaging characteristics of computed tomography].
  • In all patients the diagnosis was confirmed by surgery and histopathology.
  • Values of tissue density (HU) at CT were measured within the lesions and in the surrounding pancreatic tissue.
  • In 10 patients the resected specimen revealed an inflammatory pseudotumor, which was located in all cases within the pancreatic head.
  • Using CT these 10 patients presented with calcifications within the lesion in 50% of the cases, an irregular dilatation of the main pancreatic duct in 90%, a "double duct sign" in 70%, an interrupted main pancreatic duct in the area of the lesion in 50%, a "duct penetrating sign" in 30%, an infiltration of adjacent structures in 10% and pathologically enlarged lymph nodes in 100% of the cases.
  • In the venous contrasting phase six tumors were hypodense and four isodense compared to the surrounding pancreatic tissue.
  • In six patients biphasic CT was performed and the mean difference in attenuation between inflammatory pseudotumors and surrounding parenchyma was significantly higher in the pancreatic phase than in the venous phase.
  • DISCUSSION: Differentiation between inflammatory pseudotumors and adenocarcinoma remains difficult or even impossible.
  • Typical signs indicative of an adenocarcinoma of the pancreatic head, such as dilatation of the common bile duct and/or the main pancreatic duct as well as enlarged lymph nodes, were also found in patients with inflammatory pseudotumors.
  • [MeSH-major] Pancreas / diagnostic imaging. Pancreatic Neoplasms / diagnostic imaging. Pancreatitis, Chronic / diagnostic imaging. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 18604517.001).
  • [ISSN] 0033-832X
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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78. Jiang KR, Miao Y: [Standard with extended pancreaticoduodenectomy for adenocarcinoma of the head of the pancreas: a meta-analysis]. Zhonghua Wai Ke Za Zhi; 2007 Jan 1;45(1):9-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Standard with extended pancreaticoduodenectomy for adenocarcinoma of the head of the pancreas: a meta-analysis].
  • OBJECTIVE: To compare standard with extended pancreaticoduodenectomy for adenocarcinoma of the head of the pancreas: a meta-analysis of randomized controlled trials and prospective studies.
  • METHODS: Randomized controlled trials and prospective studies comparing standard with extended pancreaticoduodenectomy for pancreatic cancer of head were identified using a systematic search of Medline, the Cochrane Library Databases and CBMDisc covering articles published from 1996 to 2005.
  • Whipple procedure is also of choice for pancreatic head carcinoma and extended pancreaticoduodenectomy is indicated for lymph node positive patient (A-level).
  • [MeSH-major] Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / methods

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  • (PMID = 17403281.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Meta-Analysis
  • [Publication-country] China
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79. Naitoh H, Shoji H, Ishikawa I, Watanabe R, Furuta Y, Tomozawa S, Igarashi H, Shinozaki S, Katsura H, Onozato R, Kudoh M: Intraductal papillary mucinous tumor of the pancreas associated with autosomal dominant polycystic kidney disease. J Gastrointest Surg; 2005 Jul-Aug;9(6):843-5
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  • [Title] Intraductal papillary mucinous tumor of the pancreas associated with autosomal dominant polycystic kidney disease.
  • CT showed multiple cysts in the liver and both kidneys along with ADPKD and a cystic mass, 4 cm in diameter, in the pancreatic head.
  • The main pancreatic duct was dilated to 1 cm in diameter.
  • Histologic examination revealed a multiloculated cystic tumor filled with mucin in the head of the pancreas.
  • Microscopically, the tumor was diagnosed as adenocarcinoma and was found to have invaded the main pancreatic duct.
  • Although, in addition to our case, only seven cases with association between ADPKD and malignant neoplasms have been reported, five of these cases had neoplasms arising from the pancreas.
  • Therefore, we suggest that some genetic interactions may exist between ADPKD and pancreatic carcinogenesis.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Carcinoma, Pancreatic Ductal / diagnosis. Pancreatic Neoplasms / diagnosis. Pancreaticoduodenectomy / methods. Polycystic Kidney, Autosomal Dominant / diagnosis
  • [MeSH-minor] Abdominal Pain / diagnosis. Abdominal Pain / etiology. Acute Disease. Adult. Biopsy, Needle. Follow-Up Studies. Humans. Immunohistochemistry. Male. Pancreatitis / diagnosis. Pancreatitis / etiology. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome


80. Alvarado-Bachmann R, Choi J, Gananadha S, Hugh TJ, Samra JS: The infracolic approach to pancreatoduodenectomy for large pancreatic head tumours invading the colon. Eur J Surg Oncol; 2010 Dec;36(12):1220-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The infracolic approach to pancreatoduodenectomy for large pancreatic head tumours invading the colon.
  • BACKGROUND: Tumours arising from the head of the pancreas can invade both the proximal transverse colon and its mesocolon.
  • In the event of tumour invading the SMV, this is also resected en-bloc with the pancreatic head and transverse colon.
  • CONCLUSION: The infracolic technique may be used to deal with large pancreatic head tumours and all pancreatic surgeons should be familiar with this technique.
  • In the absence of metastatic disease, large pancreatic head tumours involving the colon can be resected en-bloc with the pancreatic head, as long as the SMA is not encased by the tumour.
  • [MeSH-major] Adenocarcinoma / surgery. Carcinoma, Neuroendocrine / surgery. Colonic Neoplasms / surgery. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / methods

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  • [Copyright] Crown Copyright © 2010. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20843644.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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81. Gelos M, Behringer D, Philippou S, Mann B: Pancreatic carcinosarcoma. Case report of multimodal therapy and review of the literature. JOP; 2008;9(1):50-5
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  • [Title] Pancreatic carcinosarcoma. Case report of multimodal therapy and review of the literature.
  • CONTEXT: Carcinosarcoma (malignant mixed tumor) is a rare variant of a pancreatic neoplasm having a dismal prognosis; very few clinical data and treatment options have been published.
  • Unlike adenocarcinoma of the pancreas, there is nothing specific in the literature for this variant regarding postoperative treatment with chemotherapeutic agents.
  • Examination revealed a mass in the pancreatic head and she underwent a partial pancreaticoduodenectomy.
  • Histopathological examination revealed a pancreatic neoplasm with both adenomatous as well as sarcomatous characteristics.
  • CONCLUSION: Carcinosarcoma of the pancreas is a very rare disease having a dismal prognosis.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Carcinosarcoma / drug therapy. Carcinosarcoma / surgery. Deoxycytidine / analogs & derivatives. Pancreatic Neoplasms / drug therapy. Pancreatic Neoplasms / surgery

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  • (PMID = 18182744.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
  • [Number-of-references] 14
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82. Pilleul F, Rochette A, Partensky C, Scoazec JY, Bernard P, Valette PJ: Preoperative evaluation of intraductal papillary mucinous tumors performed by pancreatic magnetic resonance imaging and correlated with surgical and histopathologic findings. J Magn Reson Imaging; 2005 Mar;21(3):237-44
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  • [Title] Preoperative evaluation of intraductal papillary mucinous tumors performed by pancreatic magnetic resonance imaging and correlated with surgical and histopathologic findings.
  • PURPOSE: To evaluate the effectiveness of magnetic resonance imaging (MRI) in predicting the location, type of ductal involvement, and malignant transformation of intraductal papillary mucinous (IPM) pancreatic tumors made in a preoperative routine exam.
  • The lesions were located mainly in the head or uncinate process (N = 16) or were diffuse or multifocal (N = 2).
  • Excellent agreement was found between the interpreters (0.90) in the evaluation of ductal involvement, good in the evaluation of lesion location (0.80) and in the diagnosis of malignant transformation (0.74).
  • The correlation between MRI and histopathologic results was excellent in the evaluation of ductal involvement (0.90, sensitivity = 100%, specificity = 94%) and moderate in the evaluation of lesion location (0.57, sensitivity = 87%, specificity = 56%) and in the diagnosis of malignant transformation (0.60, sensitivity = 83%, specificity = 83%).
  • The predictive sign of IPM pancreatic tumor malignancy at MRI included only the presence of solid mass or mural nodules.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Carcinoma, Pancreatic Ductal / diagnosis. Magnetic Resonance Imaging / methods. Pancreas / pathology. Pancreatic Neoplasms / diagnosis

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15723374.001).
  • [ISSN] 1053-1807
  • [Journal-full-title] Journal of magnetic resonance imaging : JMRI
  • [ISO-abbreviation] J Magn Reson Imaging
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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83. Seelig SK, Burkert B, Chromik AM, Tannapfel A, Uhl W, Seelig MH: Pancreatic resections for advanced M1-pancreatic carcinoma: the value of synchronous metastasectomy. HPB Surg; 2010;2010:579672
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  • [Title] Pancreatic resections for advanced M1-pancreatic carcinoma: the value of synchronous metastasectomy.
  • BACKGROUND: For M1 pancreatic adenocarcinomas pancreatic resection is usually not indicated.
  • However, in highly selected patients synchronous metastasectomy may be appropriate together with pancreatic resection when operative morbidity is low.
  • MATERIALS AND METHODS: From January 1, 2004 to December, 2007 a total of 20 patients with pancreatic malignancies were retrospectively evaluated who underwent pancreatic surgery with synchronous resection of hepatic, adjacent organ, or peritoneal metastases for proven UICC stage IV periampullary cancer of the pancreas.
  • The primary tumor was located in the pancreatic head (n = 9, 45%), in pancreatic tail (n = 9, 45%), and in the papilla Vateri (n = 2, 10%).
  • Median postoperative survival was 10.7 months (2.6-37.7 months) which was not significantly different from a matched-pair group of patients who underwent pancreatic resection for UICC adenocarcinoma of the pancreas (median survival 15.6 months; P = .1).
  • CONCLUSION: Pancreatic resection for M1 periampullary cancer of the pancreas can be performed safely in well-selected patients.
  • [MeSH-major] Carcinoma / secondary. Carcinoma / surgery. Pancreatectomy. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / surgery

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  • (PMID = 21197481.001).
  • [ISSN] 1607-8462
  • [Journal-full-title] HPB surgery : a world journal of hepatic, pancreatic and biliary surgery
  • [ISO-abbreviation] HPB Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3010622
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84. Olivié D, Lepanto L, Billiard JS, Audet P, Lavallée JM: Predicting resectability of pancreatic head cancer with multi-detector CT. Surgical and pathologic correlation. JOP; 2007;8(6):753-8
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  • [Title] Predicting resectability of pancreatic head cancer with multi-detector CT. Surgical and pathologic correlation.
  • CONTEXT: Computed tomography is widely used to pre-operatively evaluate patients with ductal carcinoma of the pancreas.
  • OBJECTIVE: To prospectively evaluate the ability of multi-detector computed tomography to predict resectability of pancreatic head cancer.
  • PATIENTS: Ninety-one consecutive patients (53 men, 38 women; mean age, 61 years) referred to our department with a diagnosis of cancer of the head of the pancreas underwent a preoperative contrast enhanced triphasic 16-slice multi-detector computed tomography.
  • RESULTS: Of the 91 patients evaluated, 25% had successful resection of pancreatic head carcinoma; while only 5% had a palliative procedure.
  • [MeSH-major] Adenocarcinoma / radiography. Adenocarcinoma / surgery. Pancreatic Neoplasms / radiography. Pancreatic Neoplasms / surgery. Tomography, Spiral Computed / methods

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  • (PMID = 17993727.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Italy
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85. Fabbrini F, Anfray P, Viacava P, Gregori M, Abramo F: Feline cutaneous and visceral necrotizing panniculitis and steatitis associated with a pancreatic tumour. Vet Dermatol; 2005 Dec;16(6):413-9
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  • [Title] Feline cutaneous and visceral necrotizing panniculitis and steatitis associated with a pancreatic tumour.
  • The association of pancreatic disorders with fat necrosis in domestic animals is rare.
  • This report concerns a case of cutaneous/subcutaneous necrotizing panniculitis and steatitis associated with a pancreatic adenocarcinoma in an 11-year-old male Siamese cat.
  • The cat was euthanized at the owner's request before a diagnosis could be made.
  • A multilobulated mass arising from the anterior pancreatic head was found along with liver and lymph node metastasis.
  • Duct-like structures and tubules lined by neoplastic epithelial cells were observed in the primary pancreatic tumour and in the metastatic sites.
  • The aetiology of the fat necrosis was possibly the result of systemic release of lipolytic pancreatic enzymes.
  • [MeSH-major] Adenocarcinoma / veterinary. Cat Diseases / diagnosis. Pancreatic Neoplasms / veterinary. Panniculitis / veterinary. Steatitis / diagnosis
  • [MeSH-minor] Animals. Cats. Fatal Outcome. Male. Necrosis / veterinary. Pancreas / enzymology. Pancreas / pathology

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  • (PMID = 16359310.001).
  • [ISSN] 0959-4493
  • [Journal-full-title] Veterinary dermatology
  • [ISO-abbreviation] Vet. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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86. Saif MW: Primary pancreatic lymphomas. JOP; 2006;7(3):262-73
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  • [Title] Primary pancreatic lymphomas.
  • Primary pancreatic lymphomas are extremely rare.
  • Clinically, primary pancreatic lymphomas usually present with symptoms of carcinoma of the pancreatic head.
  • Patients with primary pancreatic lymphomas are between 35 and 75 years of age and with a strong male predominance.
  • An accurate cytopathologic diagnosis by fine-needle aspiration (FNA) is imperative because the primary treatment is non-surgical.
  • FNA coupled with flow cytometry analysis appears to be highly accurate in the diagnosis of primary pancreatic lymphomas.
  • Fluorescence in-situ hybridisation technique has been established its role in the diagnosis of lymphoid malignancies, including primary pancreatic lymphomas.
  • The differential diagnoses of primary pancreatic lymphomas include secondary lymphoma, pancreatic endocrine neoplasm, and florid chronic pancreatitis.
  • Primary pancreatic lymphomas has a much better prognosis than adenocarcinoma of the pancreas.
  • [MeSH-major] Lymphoma / diagnosis. Pancreatic Neoplasms / diagnosis

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  • (PMID = 16685107.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 40
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87. Sweeney AD, Wu MF, Hilsenbeck SG, Brunicardi FC, Fisher WE: Value of pancreatic resection for cancer metastatic to the pancreas. J Surg Res; 2009 Oct;156(2):189-98
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  • [Title] Value of pancreatic resection for cancer metastatic to the pancreas.
  • BACKGROUND: Cancer metastatic to the pancreas from other primary sites is uncommon, and it has been treated with an aggressive surgical approach in fit patients when the primary tumor is controlled and the pancreas is the only site of metastatic disease.
  • The value of pancreatic resection in this setting is unclear.
  • The purpose of this study was to review cases of cancer metastatic to the pancreas.
  • METHODS: We reviewed our experience with cancer metastatic to the pancreas and the literature regarding resection of pancreatic metastases.
  • RESULTS: A total of 220 patients with pancreatic metastasis were analyzed.
  • In the 189 patients for whom the location of the metastasis in the pancreas was revealed, the most common location was the head of the pancreas (n=79, 41.8%).
  • Surgical resection was attempted in 177 of 220 patients; 135 patients suffering from renal cell carcinoma (RCC) metastasis also underwent pancreatic resection.
  • CONCLUSION: Survival after resection of RCC with isolated metastasis to the pancreas is favorable.
  • However, a more detailed analysis considering outcomes without surgery for each primary tumor site is needed before the value of this aggressive surgical approach can be completely assessed in the general occurrence of pancreatic metastasis.
  • [MeSH-major] Carcinoma, Renal Cell / surgery. Kidney Neoplasms / pathology. Pancreatectomy. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / secondary. Adenocarcinoma / surgery. Adult. Aged. Aged, 80 and over. Breast Neoplasms / pathology. Female. Humans. Lung Neoplasms / pathology. Male. Middle Aged. Survival Analysis


88. Gaedcke J, Gunawan B, Grade M, Szöke R, Liersch T, Becker H, Ghadimi BM: The mesopancreas is the primary site for R1 resection in pancreatic head cancer: relevance for clinical trials. Langenbecks Arch Surg; 2010 Apr;395(4):451-8
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  • [Title] The mesopancreas is the primary site for R1 resection in pancreatic head cancer: relevance for clinical trials.
  • PURPOSE: The prognosis of patients with pancreatic cancer remains poor, even after potentially curative R0 resection.
  • MATERIALS AND METHODS: To test this hypothesis, color coding of all resection margins and organ surfaces as part of a standardized histopathological workup was implemented and prospectively tested on 100 pancreatic head specimens.
  • RESULTS: Thirty-five patients were excluded from the analysis owing to the pathohistological diagnosis; only pancreatic ductal adenocarcinoma, distal bile duct adenocarcinoma, and periampullary adenocarcinoma were included.
  • Applying the International Union Against Cancer criteria, 32 cancer resections were classified R0 (49.2%), while 33 cases turned out to be R1 resections (50.8%).
  • CONCLUSION: Using the intensified histopathological workup for pancreatic head cancer specimens resulted in an increased rate of R1 resections and the mesopancreas represents the primary site for positive resection margins.

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  • (PMID = 19418067.001).
  • [ISSN] 1435-2451
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2848727
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89. Sakpal SV, Sexcius L, Babel N, Chamberlain RS: Agenesis of the dorsal pancreas and its association with pancreatic tumors. Pancreas; 2009 May;38(4):367-73
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  • [Title] Agenesis of the dorsal pancreas and its association with pancreatic tumors.
  • Morphogenesis of the pancreas is a complex process; nevertheless, congenital anomalies are rare.
  • At embryogenesis, the pancreas develops from the endoderm-lined dorsal and ventral buds of the duodenum.
  • The ventral bud gives rise to the lower head and uncinate process of the pancreas; whereas, the dorsal bud gives rise to the upper head, isthmus, body, and tail of the pancreas.
  • Rarely, developmental failure of the dorsal pancreatic bud at embryogenesis results in the agenesis of the dorsal pancreas--neck, body, and tail.
  • Even rarer is the association of pancreatic tumors with agenesis of the dorsal pancreas.
  • In addition to citing our case, we provide a comprehensive review on agenesis of the dorsal pancreas and its association with pancreatic tumors.
  • [MeSH-major] Pancreas / abnormalities. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / surgery. Carcinoma, Pancreatic Ductal / diagnosis. Carcinoma, Pancreatic Ductal / surgery. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / surgery. Diagnosis, Differential. Humans. Male. Middle Aged. Tomography, X-Ray Computed


90. Varty PP, Yamamoto H, Farges O, Belghiti J, Sauvanet A: Early retropancreatic dissection during pancreaticoduodenectomy. Am J Surg; 2005 Apr;189(4):488-91
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  • METHODS: Modification of the technique of pancreaticoduodenectomy with dissection of the superior mesenteric vessels performed from behind the head of the pancreas before any pancreatic or digestive transection.
  • The pancreas is divided later, after adequate mobilization of the specimen from the vessels, on either the neck or the body, according to underlying disease.
  • Additionally, we used this technique in 18 patients with IPMN-14 pancreaticoduodenectomies extended to the body and 4 total pancreatectomies-and in 3 patients with adenocarcinoma involving the porto-mesenteric confluence and needing en-bloc vascular resection.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / surgery. Cystadenoma, Papillary / surgery. Neoplasm Invasiveness / pathology. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / methods

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  • (PMID = 15820467.001).
  • [ISSN] 0002-9610
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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91. Bergenfeldt M, Moesgaard F, Burcharth F: Curative resection for left-sided pancreatic malignancy. HPB (Oxford); 2006;8(3):211-5
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  • [Title] Curative resection for left-sided pancreatic malignancy.
  • BACKGROUND: Surgical technique in pancreatic cancer has seen significant developments, but much of the knowledge refers to pancreatic head carcinoma.
  • Current knowledge teaches that adenocarcinomas of the body and tail of the pancreas have a worse prognosis.
  • The aim of this study is to report the short- and long-term outcome in 20 patients with left-sided pancreatic malignancy, where 'resection for cure' was done.
  • The patients with ductal adenocarcinoma had a median survival of 14 months and a 5-year survival of 17%.
  • One patient with malignant insulinoma and two patients with adenocarcinoma had a survival exceeding 5 years (98, 174 and 183 months, respectively).
  • DISCUSSION: Selected patients with left-sided pancreatic adenocarcinoma may be operated on with results similar to pancreaticoduodenectomy (Whipple procedure) for cancer of the pancreatic head regarding postoperative morbidity and mortality as well as long-term survival.
  • Thus, although left-sided pancreatic cancer generally appears at a more advanced stage, it seems true that treatment results are similar if radical excision can be achieved.

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  • (PMID = 18333279.001).
  • [ISSN] 1365-182X
  • [Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association
  • [ISO-abbreviation] HPB (Oxford)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2131678
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92. Ardengh JC, Lopes CV, Campos AD, Pereira de Lima LF, Venco F, Módena JL: Endoscopic ultrasound and fine needle aspiration in chronic pancreatitis: differential diagnosis between pseudotumoral masses and pancreatic cancer. JOP; 2007;8(4):413-21
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  • [Title] Endoscopic ultrasound and fine needle aspiration in chronic pancreatitis: differential diagnosis between pseudotumoral masses and pancreatic cancer.
  • CONTEXT: Pseudotumoral chronic pancreatitis can be difficult to differentiate from pancreatic carcinoma.
  • PATIENTS AND INTERVENTIONS: Between February 1997 and December 2006, 69 pancreatic head masses from patients with alcoholic chronic pancreatitis underwent EUS-FNA using a linear echoendoscope and 22-gauge needles.
  • The patients were subdivided into two groups: pseudotumoral chronic pancreatitis and pancreatic cancer.
  • RESULTS: Pseudotumoral masses and adenocarcinoma were found in 58 and 11 patients, respectively.
  • The size of the lesions and the clinical presentation were similar in both groups, but the cancer patients were older than the patients with pseudotumoral masses (P=0.020).
  • EUS-FNA confirmed the final diagnosis in 66 of the 69 (95.7%) cases.
  • Three of the 11 (27.3%) cancers were misdiagnosed as pseudotumoral masses, and no pseudotumoral mass was diagnosed as a cancer.
  • CONCLUSIONS: The diagnostic accuracy of endoscopic ultrasound alone for differentiating between pseudotumoral masses and pancreatic cancer arising from chronic pancreatitis is unsatisfactory.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / ultrasonography. Granuloma, Plasma Cell / pathology. Granuloma, Plasma Cell / ultrasonography. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / ultrasonography. Pancreatitis, Chronic / pathology. Pancreatitis, Chronic / ultrasonography
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Diagnosis, Differential. Endoscopy, Digestive System. Endosonography. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. Sensitivity and Specificity


93. Sparks DA, Chase DM, Forsyth M, Bogen G, Arnott J: Late presentation of a mucinous ovarian adenocarcinoma which was initially diagnosed as a primary pancreatic carcinoma: a case report and review of the literature. J Med Case Rep; 2010;4:90
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  • [Title] Late presentation of a mucinous ovarian adenocarcinoma which was initially diagnosed as a primary pancreatic carcinoma: a case report and review of the literature.
  • INTRODUCTION: Adenocarcinoma of the ovary is an aggressive neoplasm which often metastasizes to the lung or liver.
  • Metastases rarely occur to the pancreas, but a tissue diagnosis is required to confirm this event.
  • Although most tumors of the pancreas are primary pancreatic neoplasms, metastatic lesions have been reported most commonly as arising from renal cell carcinoma.
  • CASE PRESENTATION: We report the case of a 51-year-old Caucasian woman with ovarian mucinous adenocarcinoma with metastasis to the head of the pancreas that was originally misdiagnosed as a pancreatic primary tumor.
  • CONCLUSION: Mucinous ovarian adenocarcinomas rarely metastasize to the pancreas.
  • New pancreatic lesions should be investigated through tissue biopsy and tumor markers, while keeping an open-minded differential diagnosis to avoid a misdiagnosis or a delay in treatment.

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  • (PMID = 20298585.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2851597
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94. Schnelldorfer T, Ware AL, Sarr MG, Smyrk TC, Zhang L, Qin R, Gullerud RE, Donohue JH, Nagorney DM, Farnell MB: Long-term survival after pancreatoduodenectomy for pancreatic adenocarcinoma: is cure possible? Ann Surg; 2008 Mar;247(3):456-62
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  • [Title] Long-term survival after pancreatoduodenectomy for pancreatic adenocarcinoma: is cure possible?
  • OBJECTIVE: To determine long-term survival after pancreatoduodenectomy for pancreatic ductal adenocarcinoma and to identify clinical factors associated with long-term survival.
  • SUMMARY BACKGROUND DATA: The prognosis for long-term survival even after potentially curative resection for pancreatic adenocarcinoma is thought to be poor.
  • Clinical factors determining short-term survival after pancreatic resection are well studied, but prognostic factors predicting long-term survival with a potential for cure are poorly understood.
  • METHODS: A case-control study was conducted of 357 patients who underwent pancreatoduodenectomy for pancreatic ductal adenocarcinoma between 1981 and 2001.
  • Histologic specimens were reanalyzed to confirm diagnosis.
  • Five-year survival was no guarantee of cure because 16% of this subset died of pancreatic cancer up to 7.8 years after operation.
  • CONCLUSION: Pancreatoduodenectomy for adenocarcinoma in the head of pancreas can provide long-term survival in a subset of patients, particularly in the absence of lymph node metastasis.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / surgery. Pancreatic Neoplasms / mortality. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy

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  • (PMID = 18376190.001).
  • [ISSN] 0003-4932
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Serum Albumin
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95. Shukla RC, Pathak R, Senthil S: Pancreatic metastases of renal cell carcinoma--case report. Nepal Med Coll J; 2008 Dec;10(4):275-7
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  • [Title] Pancreatic metastases of renal cell carcinoma--case report.
  • Metastasis to the pancreas from renal cell carcinoma is distinctly uncommon.
  • A solitary renal cell carcinoma (RCC) metastasis to the head of pancreas is rarely encountered.
  • Ultrasound of abdomen revealed an encapsulate mass in the kidney plus a mass in the head of pancreas, but no other distant metastases.
  • Fine needle aspiration from the mass in the head of the pancreas confirmed the diagnosis of metastatic renal cell carcinoma, clear cell type.
  • In the absence of widespread disease, pancreatic resection can provide long term survival in metastatic RCC, although few cases have been reported with lengthy follow up.
  • The prognosis is better than for pancreatic adenocarcinoma.
  • [MeSH-major] Carcinoma, Renal Cell / secondary. Kidney Neoplasms / pathology. Pancreatic Neoplasms / secondary


96. Nagano H, Koneri K, Honda K, Murakami M, Hirono Y, Maeda H, Goi T, Iida A, Katayama K, Yamaguchi A: Biliopancreatic fistula and abscess formation in the bursa omentalis associated with intraductal papillary mucinous cancer of the pancreas. Int J Clin Oncol; 2009 Oct;14(5):460-4
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  • [Title] Biliopancreatic fistula and abscess formation in the bursa omentalis associated with intraductal papillary mucinous cancer of the pancreas.
  • Abdominal computed tomography (CT) revealed findings consistent with an intraductal papillary mucinous neoplasm (IPMN) of the pancreas, accompanied by abscess formation in the bursa omentalis.
  • Gastrointestinal fiberscopy revealed a swollen papilla of Vater expanded by sticky mucus, and a communication between the pancreatic duct and bile duct was demonstrated by the injection of indigo carmine solution into the pancreatic duct.
  • Pathological examination revealed IPMN with patchy, scattered carcinoma of the pancreatic head and uncinate process with the formation of a biliopancreatic fistula.
  • [MeSH-major] Abdominal Abscess / etiology. Adenocarcinoma, Mucinous / complications. Biliary Fistula / etiology. Carcinoma, Pancreatic Ductal / complications. Carcinoma, Papillary / complications. Pancreatic Fistula / etiology. Pancreatic Neoplasms / complications

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  • (PMID = 19856058.001).
  • [ISSN] 1437-7772
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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97. Nakano T, Sonobe H, Usui T, Yamanaka K, Ishizuka T, Nishimura E, Hanazaki K: Immunohistochemistry and K-ras sequence of pancreatic carcinosarcoma. Pathol Int; 2008 Oct;58(10):672-7
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  • [Title] Immunohistochemistry and K-ras sequence of pancreatic carcinosarcoma.
  • Herein is presented a case of carcinosarcoma of the pancreas in an 82-year-old woman, analyzed on immunohistochemistry and K-ras sequence.
  • The tumor, which arose in the pancreas head, was removed on pancreaticoduodenectomy.
  • Microscopically, the tumor consisted of malignant epithelial (well-differentiated adenocarcinoma cells) and mesenchymal (spindle-shaped tumor cells) components.
  • The adenocarcinoma cells had positive immunostaining for cytokeratin AE1/AE3, cytokeratin 7, epithelial membrane antigen (EMA), CEA and carbohydrate antigen 19-9 (CA 19-9), while focal staining of these proteins was observed in the sarcomatous cells.
  • In contrast, the sarcomatous cells had diffuse immunostaining for vimentin, CD10 and p53, while these proteins were not expressed in the ductal adenocarcinoma cells.
  • [MeSH-major] Carcinosarcoma / pathology. Genes, ras / genetics. Pancreatic Neoplasms / pathology. Point Mutation

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  • (PMID = 18801090.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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98. Todoroki T, Sano T, Yamada S, Hirahara N, Toda N, Tsukada K, Motojima R, Motojima T: Clear cell carcinoid tumor of the distal common bile duct. World J Surg Oncol; 2007;5:6
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  • Under suspicion of carcinoma, we resected the head of the pancreas along with 2nd portion duodenectomy and a lymph node dissection.
  • Immunohistochemical stains showed that neoplastic cells were positive for neuron-specific enolase (NSE), chromogranin A, synaptophysin, and pancreatic polypeptide and negative for inhibin, keratin, CD56, serotonin, gastrin and somatostatin.
  • CONCLUSION: Given the preoperative difficulty in differentiating carcinoid from carcinoma, the pancreaticoduodenectomy is an appropriate treatment choice for carcinoid tumors located within the intra-pancreatic bile duct.
  • [MeSH-major] Carcinoid Tumor / diagnosis. Carcinoid Tumor / surgery. Common Bile Duct Neoplasms / diagnosis. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Adenocarcinoma, Clear Cell / diagnosis. Adenocarcinoma, Clear Cell / pathology. Adenocarcinoma, Clear Cell / surgery. Aged. Biopsy, Needle. Cholangiopancreatography, Endoscopic Retrograde. Cholangiopancreatography, Magnetic Resonance. Follow-Up Studies. Humans. Immunohistochemistry. Laparotomy / methods. Male. Neoplasm Staging. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome. Ultrasonography, Doppler

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  • (PMID = 17227590.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 52
  • [Other-IDs] NLM/ PMC1785380
  • [General-notes] NLM/ Original DateCompleted: 20070802
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99. Xu J, Liang Z, Hao S, Zhu L, Ashish M, Jin C, Fu D, Ni Q: Pancreatic adenocarcinoma: dynamic 64-slice helical CT with perfusion imaging. Abdom Imaging; 2009 Nov;34(6):759-66
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  • [Title] Pancreatic adenocarcinoma: dynamic 64-slice helical CT with perfusion imaging.
  • Thus, in lesions of the tissues of the pancreas, this offers to increase the accuracy of CT diagnosis.
  • In this study, our aim was to explore the perfusion characteristics of normal pancreas and pancreatic adenocarcinoma.
  • METHODS: Dynamic 64-slice helical CT was conducted in 36 patients with non-pancreatic disease and in 40 patients with histopathologically proven pancreatic adenocarcinoma.
  • RESULTS: There was no significant difference noted between the distribution of BF, BV, and PS values in different regions of the pancreas, namely the head, neck, body, and tail (P > 0.05).
  • The BF, BV, and PS of normal pancreas were recorded as 135.24 +/- 48.36 ml min(-1) 100 g(-1), 200.55 +/- 54.96 ml 100 g(-1), and 49.75 +/- 24.27 ml min(-1) 100 g(-1), respectively.
  • BF, BV, and PS values of the tumor tissue of pancreatic adenocarcinoma decreased significantly compared to normal pancreas (P < 0.05).
  • CONCLUSIONS: Normal pancreas appears homogenous on perfusion CT.
  • A significant decrease of BF, BV, and PS was observed in pancreatic adenocarcinoma.
  • Dynamic 64-slice helical CT with perfusion imaging should be considered a potential modality to increase the accuracy of CT diagnosis for pancreatic adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / radiography. Pancreatic Neoplasms / radiography. Tomography, Spiral Computed / methods
  • [MeSH-minor] Case-Control Studies. Contrast Media. Female. Humans. Iohexol. Male. Middle Aged. Pancreas / blood supply. Pancreas / radiography. Pancreaticoduodenectomy. Prospective Studies

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  • (PMID = 19672566.001).
  • [ISSN] 1432-0509
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 4419T9MX03 / Iohexol
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100. Demirkan B, Unek IT, Eriksson B, Akarsu M, Durak H, Sağol O, Obuz F, Binicier C, Füzün M, Alakavuklar M: A patient with nonfunctional pancreatic neuroendocrine tumor and incidental metachronous colon carcinoma detected by positron emission tomography: case report. Turk J Gastroenterol; 2009 Sep;20(3):214-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A patient with nonfunctional pancreatic neuroendocrine tumor and incidental metachronous colon carcinoma detected by positron emission tomography: case report.
  • Pancreatic neuroendocrine tumors constitute about 2% of all gastrointestinal neoplasms.
  • Approximately half of the pancreatic euroendocrine tumors are nonfunctional.
  • Due to lack of specific symptoms, most patients with nonfunctional pancreatic neuroendocrine tumors present with locally advanced or metastatic disease.
  • Colon carcinoma ranks third in frequency among primary sites of cancer in both men and women in western countries.
  • Presence of a metachronous colon adenocarcinoma in a patient with nonfunctional pancreatic neuroendocrine tumor has not been reported before.
  • We present a patient who had an asymptomatic mass in the head of the pancreas, detected by ultrasonography in 1996.
  • In 2002, after the diagnosis of an unresectable, nonfunctional pancreatic neuroendocrine tumor, interferon alpha- 2b and octreotide were started.
  • [MeSH-major] Adenocarcinoma / radionuclide imaging. Colonic Neoplasms / radionuclide imaging. Neoplasms, Second Primary / radionuclide imaging. Neuroendocrine Tumors / radionuclide imaging. Pancreatic Neoplasms / radionuclide imaging. Positron-Emission Tomography

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  • (PMID = 19821205.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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