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[Title] Gingival metastasis from gastric adenocarcinoma.

[MeSH-major] Adenocarcinoma / secondary. Gingival Neoplasms / secondary. Stomach Neoplasms / pathology

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(PMID = 17599589.001).

[ISSN] 0194-5998

[Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

[ISO-abbreviation] Otolaryngol Head Neck Surg

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

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[Title] Scintigraphy for interpretation of malignant tumours of the head and neck: comparison of technetium-99m-hexakis-2-methoxyisobutylisonitrile (Tc-MIBI) and thallium-201-chloride (Tl-201).

METHODS: Dynamic and static scintigraphic imaging with 99Tc(m)-MIBI and Tl-201 were performed on patients with a variety of malignant and benign tumours.

In addition to these factors, the grade of tissue differentiation and tumour size were evaluated to clarify the difference between 99Tc(m)-MIBI and Tl-201 for the diagnosis of malignant tumours of the head and neck.

CONCLUSIONS: There was no major difference between 99Tc(m)-MIBI and Tl-201scintigraphy with respect to accuracy of diagnosis of malignant tumours of the head and neck.

[MeSH-major] Carcinoma, Squamous Cell / radionuclide imaging. Head and Neck Neoplasms / radionuclide imaging. Radiopharmaceuticals. Technetium Tc 99m Sestamibi. Thallium Radioisotopes

[MeSH-minor] Adenocarcinoma / radionuclide imaging. Adenolymphoma / radionuclide imaging. Adenoma, Pleomorphic / radionuclide imaging. Adult. Aged. Aged, 80 and over. Cell Differentiation. Female. Humans. Male. Middle Aged. Regional Blood Flow / physiology. Retrospective Studies. Thallium. Time Factors

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Hazardous Substances Data Bank. THALLIUM, ELEMENTAL .

Hazardous Substances Data Bank. THALLOUS CHLORIDE .

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(PMID = 16120875.001).

[ISSN] 0250-832X

[Journal-full-title] Dento maxillo facial radiology

[ISO-abbreviation] Dentomaxillofac Radiol

[Language] eng

[Publication-type] Case Reports; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Radiopharmaceuticals; 0 / Thallium Radioisotopes; 7791-12-0 / thallium chloride; 971Z4W1S09 / Technetium Tc 99m Sestamibi; AD84R52XLF / Thallium

   

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[Title] Single nucleotide polymorphism in DNA methyltransferase 3B promoter and its association with gastric cardiac adenocarcinoma in North China.

AIM: To investigate the association between single nucleotide polymorphism (SNP) in promoter of the DNA methyltransferase 3B (DNMT3B) gene and risk for development and lymphatic metastasis of gastric cardiac adenocarcinoma (GCA).

Although this SNP has been associated with susceptibility to lung, head, neck and breast cancer, it may not be used as a stratification marker to predict susceptibility and lymphatic metastasis of GCA, at least in the population of North China.

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(PMID = 15962389.001).

[ISSN] 1007-9327

[Journal-full-title] World journal of gastroenterology

[ISO-abbreviation] World J. Gastroenterol.

[Language] ENG

[Grant] United States / NIH HHS / JT / C2000062

[Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] EC 2.1.1.37 / DNA (Cytosine-5-)-Methyltransferase; EC 2.1.1.37 / DNA methyltransferase 3B

[Other-IDs] NLM/ PMC4315975

   

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[MeSH-major] Adenocarcinoma, Follicular / secondary. Lymphoma / pathology. Neoplasms, Second Primary / pathology. Thyroid Neoplasms / pathology

[MeSH-minor] Combined Modality Therapy. Female. Humans. Middle Aged. Neoplasm Metastasis. Salvage Therapy

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[Cites] J Nucl Biol Med. 1994 Mar;38(1):18-21 [8075172.001]

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(PMID = 20614316.001).

[ISSN] 1936-0568

[Journal-full-title] Head and neck pathology

[ISO-abbreviation] Head Neck Pathol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Other-IDs] NLM/ PMC2807566

[Keywords] NOTNLM ; Large cell lymphoma / Non-Hodgkin’s lymphoma / Skull metastasis / Thyroid carcinoma / Thyroid follicular carcinoma / Tumor-to-tumor metastasis

   

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[MeSH-minor] Adenocarcinoma, Follicular / pathology. Aged. Biopsy, Fine-Needle. Brain Neoplasms / secondary. Carcinoma, Papillary / secondary. Diagnosis, Differential. Female. Humans. Incidental Findings. Lymph Nodes / pathology. Lymphatic Metastasis. Male. Middle Aged. Prognosis. Risk Assessment. Survival Rate. Treatment Outcome

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(PMID = 17131422.001).

[ISSN] 0022-4790

[Journal-full-title] Journal of surgical oncology

[ISO-abbreviation] J Surg Oncol

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

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[Title] Clinicopathological features of head and neck adenosquamous carcinoma.

Adenosquamous carcinoma is a rare tumour which is characterized pathologically by the simultaneous presence of distinct areas of squamous cell carcinoma and adenocarcinoma.

In the present study, the medical and pathological records of 4 patients with head and neck adenosquamous carcinoma are reviewed.

[MeSH-major] Carcinoma, Adenosquamous / pathology. Head and Neck Neoplasms / pathology

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[Copyright] Copyright (c) 2005 S. Karger AG, Basel.

(PMID = 15637416.001).

[ISSN] 0301-1569

[Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties

[ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Switzerland

   

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[Title] Retrospective study and review of polymorphous low-grade adenocarcinoma.

OBJECTIVES/HYPOTHESIS: We review a single institution's experience with polymorphous low-grade adenocarcinoma.

To our knowledge, this is the largest patient series of polymorphous low-grade adenocarcinoma with clinical follow-up in the otolaryngology literature.

STUDY DESIGN: We retrospectively identified 19 patients with polymorphous low-grade adenocarcinoma who had adequate clinical follow-up and pathologic specimens available for examination.

METHODS: All pathologic materials were reviewed by one head and neck pathologist.

The most common initial diagnoses were polymorphous low-grade adenocarcinoma, adenoid cystic carcinoma, and pleomorphic adenoma.

CONCLUSIONS: Polymorphous low-grade adenocarcinoma is an increasingly recognized malignancy that originates predominantly in the minor salivary gland.

[MeSH-major] Adenocarcinoma / pathology. Salivary Gland Neoplasms / pathology

[MeSH-minor] Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Retrospective Studies. Salivary Glands, Minor

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(PMID = 17146387.001).

[ISSN] 0023-852X

[Journal-full-title] The Laryngoscope

[ISO-abbreviation] Laryngoscope

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

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SUBJECTS AND METHODS: Gender, final diagnosis, extent of resection, biology of pathology, intrathoracic involvement, surgery for recurrent multinodular goiter, and presence and number of parathyroid glands in a surgical specimen were analyzed as risk factors for postoperative transient hypoparathyroidism.

CONCLUSION: The extent of surgery to central and/or lateral neck lymph nodes is responsible for a high rate of transient hypoparathyroidism owing to a high probability of unplanned parathyroidectomy or parathyroid gland devascularization.

[MeSH-minor] Adenocarcinoma, Follicular / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Papillary / surgery. Child. Female. Follow-Up Studies. Goiter, Nodular / surgery. Goiter, Substernal / surgery. Graves Disease / surgery. Humans. Male. Middle Aged. Neck Dissection / adverse effects. Parathyroidectomy / adverse effects. Prospective Studies. Recurrence. Reoperation. Risk Factors. Thyroid Neoplasms / surgery

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(PMID = 17903586.001).

[ISSN] 0194-5998

[Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

[ISO-abbreviation] Otolaryngol Head Neck Surg

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

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[Title] [Unilateral neck mass, dysphagia and dyspnea].

Extraocular sebaceous carcinoma is a rare malignant tumor, arising from skin and salivary glands.

An important differential diagnosis in the head and neck region is metastasizing squamous cell carcinoma.

[MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Deglutition Disorders / etiology. Dyspnea / etiology. Head and Neck Neoplasms / diagnosis. Hypopharyngeal Neoplasms / diagnosis. Sebaceous Gland Neoplasms / diagnosis

[MeSH-minor] Biomarkers, Tumor / analysis. Biopsy. Diagnosis, Differential. Endoscopy. Humans. Keratin-5 / analysis. Male. Pyriform Sinus / pathology. Pyriform Sinus / surgery. Surgical Flaps. Tomography, X-Ray Computed. Tracheotomy. Ultrasonography

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[Cites] Hautarzt. 2001 Feb;52(2):147-9 [11244894.001]

[Cites] Br J Dermatol. 2003 Aug;149(2):441-2 [12932271.001]

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(PMID = 20694546.001).

[ISSN] 1433-0458

[Journal-full-title] HNO

[ISO-abbreviation] HNO

[Language] ger

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Germany

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Keratin-5

   

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[MeSH-major] Adenocarcinoma, Follicular / pathology. Adenoma, Oxyphilic / pathology. Thyroid Neoplasms / pathology

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(PMID = 19393417.001).

[ISSN] 0194-5998

[Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

[ISO-abbreviation] Otolaryngol Head Neck Surg

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

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[MeSH-major] Adenocarcinoma, Papillary / genetics. DNA, Mitochondrial / genetics. Mutation. Thyroid Neoplasms / genetics

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(PMID = 17190430.001).

[ISSN] 1673-0860

[Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery

[ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi

[Language] chi

[Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] China

[Chemical-registry-number] 0 / DNA, Mitochondrial

   

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[Title] Reduced expression and novel splice variants of ING4 in human gastric adenocarcinoma.

ING4, a new member of the ING (inhibitor of growth) family of tumour suppressor genes, has been found to be deleted or down-regulated in gliomas, breast tumours, and head and neck squamous cell carcinomas.

The goal of the present study was to investigate whether the expression and alternative splicing of ING4 transcripts are involved in the initiation and progression of stomach adenocarcinoma.

ING4 mRNA and protein expression was examined in gastric adenocarcinoma tissues and human gastric adenocarcinoma cell lines by RT-PCR, real-time RT-PCR, tissue microarray immunohistochemistry, and western blot analysis.

Our data showed that ING4 mRNA and protein were dramatically reduced in stomach adenocarcinoma cell lines and tissues, and significantly less in female than in male patients.

These variants cause a codon frame-shift and, eventually, deletion of the NLS or PHD domain contributing to the mislocalization of p53 and/or HAT/HDAC complexes and, subsequently, altered gene expression in gastric adenocarcinoma.

These results suggest that attenuated and aberrant ING4 expression may be involved in the initiation and progression of stomach adenocarcinoma.

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(PMID = 19479822.001).

[ISSN] 1096-9896

[Journal-full-title] The Journal of pathology

[ISO-abbreviation] J. Pathol.

[Language] ENG

[Grant] None / None / / 82788-1; Canada / Canadian Institutes of Health Research / / 82788-1

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / Homeodomain Proteins; 0 / ING4 protein, human; 0 / RNA, Messenger; 0 / Tumor Suppressor Proteins

[Other-IDs] NLM/ CAMS3767; NLM/ PMC3855470

   

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[MeSH-major] Adenocarcinoma / surgery. Esophageal Neoplasms / surgery. Esophagectomy. Frail Elderly

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(PMID = 20180031.001).

[ISSN] 1534-4681

[Journal-full-title] Annals of surgical oncology

[ISO-abbreviation] Ann. Surg. Oncol.

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] United States

[Other-IDs] NLM/ PMC2868167

   

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The following review summarizes the use of phospho-AKT immunohistochemistry as a potentially valuable tool in cancer prognostication in a wide spectrum of common and uncommon malignancies, including squamous carcinoma of cervix and of head and neck; adenocarcinoma of endometrium, ovarian, breast, prostate, kidney, colon, and pancreas; carcinomas of lung and thyroid; and hematopoietic, soft tissue, and central nervous system neoplasms.

To date, the findings overall suggest that the major use of p-AKT immunohistochemical staining lies in prognostication and possibly in individualization of therapy rather than in differential diagnosis.

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(PMID = 18325479.001).

[ISSN] 1092-9134

[Journal-full-title] Annals of diagnostic pathology

[ISO-abbreviation] Ann Diagn Pathol

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt

[Number-of-references] 79

   

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Prostate, pancreatic, and head and neck carcinomas have a high propensity to invade nerves.

This method may improve the diagnosis and treatment of patients with neurotrophic cancers by reducing injury to normal nerves and facilitating identification of infiltrated nerves requiring resection.

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(PMID = 18392138.001).

[ISSN] 1476-5586

[Journal-full-title] Neoplasia (New York, N.Y.)

[ISO-abbreviation] Neoplasia

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / R01 CA075416; United States / NCI NIH HHS / CA / R25 CA096945; United States / NCI NIH HHS / CA / R01 CA75416; United States / NCI NIH HHS / CA / R25-CA096945-3

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / RNA, Messenger; 0 / enhanced green fluorescent protein; 147336-22-9 / Green Fluorescent Proteins; EC 2.7.10.1 / Protein-Tyrosine Kinases

[Other-IDs] NLM/ PMC2288543

   

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OBJECTIVE: Patients with a genetic history of retinoblastoma have an increased risk of developing a second neoplasm.

We present the first case of a radiation induced adenocarcinoma in a patient after treatment for retinoblastoma.

The patient underwent surgical resection and pathology revealed an adenocarcinoma.

This is the first case of a sinonasal adenocarcinoma occurring in the previously irradiated field.

The endoscopic skull base surgeon plays a vital role as patient survival depends on the diagnosis and surgical management.

[MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / etiology. Neoplasms, Radiation-Induced / diagnosis. Neoplasms, Second Primary / diagnosis. Neoplasms, Second Primary / etiology. Nose Neoplasms / diagnosis. Nose Neoplasms / etiology. Retinal Neoplasms / radiotherapy. Retinoblastoma / radiotherapy

[MeSH-minor] Adult. Diagnosis, Differential. Endoscopy. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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(PMID = 21225836.001).

[ISSN] 1531-4995

[Journal-full-title] The Laryngoscope

[ISO-abbreviation] Laryngoscope

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

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[Title] Esophageal granular cell tumor colliding with intramucosal adenocarcinoma: a case report.

We report a case of a granular cell tumor colliding with intramucosal adenocarcinoma of the esophagus.

Endoscopic biopsies revealed intramucosal adenocarcinoma arising in the setting of Barrett's esophagus.

The adenocarcinoma infiltrated a granular cell tumor also present at the nodular site.

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(PMID = 19830048.001).

[ISSN] 1757-1626

[Journal-full-title] Cases journal

[ISO-abbreviation] Cases J

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Other-IDs] NLM/ PMC2740250

   

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Metastatic renal cell carcinoma (RCC) can pose diagnostic challenges in the head and neck often resembling benign and malignant oncocytic lesions.

Nineteen oncocytomas, 9 cases of oncocytosis, 9 oncocytic carcinomas and 16 head and neck metastatic RCC were studied.

While clinical history and morphology usually are adequate, demonstration of p63 staining can definitively exclude metastatic RCC from the differential diagnosis of similar appearing tumors in salivary glands, namely oncocytoma and oncocytic carcinoma, with 100% specificity and sensitivity.

[MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Adenoma, Oxyphilic / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Membrane Proteins / metabolism. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / metabolism

[MeSH-minor] Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Predictive Value of Tests

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(PMID = 20614263.001).

[ISSN] 1936-0568

[Journal-full-title] Head and neck pathology

[ISO-abbreviation] Head Neck Pathol

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / Membrane Proteins

[Other-IDs] NLM/ PMC2807526

[Keywords] NOTNLM ; Metastatic renal cell carcinoma / Oncocytic carcinoma / Oncocytoma / p63

   

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MATERIALS AND METHODS: In the five Danish head and neck oncology centres, charts of all consecutive patients with sino-nasal carcinomas were reviewed and data extracted to a common database.

Histologies included squamous cell carcinoma (55%), adenocarcinoma (28.5%), adenoid-cystic carcinoma (5.0%), undifferentiated carcinoma (4.5%), transitiocellular carcinoma (1.7%), mucoepidermoid carcinoma (0.8%), neuroendocrine carcinoma (2.5%), small cell carcinomas (1.2%) and carcinomas not otherwise specified (0.8%).

Most failures were in T-site (63, 30%).

N-site failures were 10 (5%) and M-site failures six (3%).

Failure occurring in T+N-site, T+M-site, N+M-site and T+N+M-site were seven (3%), two (1%), one (0.5%) and five (3%) respectively.

Female gender, nasal cavity tumour, adenocarcinoma and low clinical stage were significant positive prognostic factors in univariate analysis.

A Cox multivariate analysis showed that only tumour site and clinical stage were independent significant prognostic factors.

CONCLUSION: The current series has confirmed stage and tumour site as independent prognostic factors.

[MeSH-minor] Adenocarcinoma / epidemiology. Adult. Aged. Aged, 80 and over. Carcinoma, Mucoepidermoid / epidemiology. Carcinoma, Neuroendocrine / epidemiology. Carcinoma, Small Cell / epidemiology. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Transitional Cell / epidemiology. Cystadenocarcinoma / epidemiology. Denmark / epidemiology. Disease-Free Survival. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Multivariate Analysis. Proportional Hazards Models

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(PMID = 20001493.001).

[ISSN] 1651-226X

[Journal-full-title] Acta oncologica (Stockholm, Sweden)

[ISO-abbreviation] Acta Oncol

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

   

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Primary mucinous carcinoma of the skin is a rare malignant tumour originating from the sweat glands.

[MeSH-major] Adenocarcinoma, Mucinous / pathology. Head and Neck Neoplasms / pathology. Skin Neoplasms / pathology

[MeSH-minor] Diagnosis, Differential. Female. Humans. Lymphatic Metastasis. Middle Aged. Sweat Gland Neoplasms / pathology. Sweat Gland Neoplasms / secondary. Sweat Gland Neoplasms / surgery

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(PMID = 18976594.001).

[ISSN] 1603-6824

[Journal-full-title] Ugeskrift for laeger

[ISO-abbreviation] Ugeskr. Laeg.

[Language] dan

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Denmark

   

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[Title] Diminishing diagnosis of follicular thyroid carcinoma.

[MeSH-major] Adenocarcinoma, Follicular / diagnosis. Thyroid Neoplasms / diagnosis

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(PMID = 20848402.001).

[ISSN] 1097-0347

[Journal-full-title] Head & neck

[ISO-abbreviation] Head Neck

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

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Pathology revealed a well-differentiated adenocarcinoma and the dissected lymph nodes were negative for malignancy.

He also complained of a mass in his neck, which had grown slowly for over 5 years.

A computed tomography scan of the neck revealed a left thyroid mass compressing the trachea towards the right side.

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(PMID = 18811948.001).

[ISSN] 1752-1947

[Journal-full-title] Journal of medical case reports

[ISO-abbreviation] J Med Case Rep

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Other-IDs] NLM/ PMC2557019

   

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BACKGROUND: In most populations, incidence rates of upper gastrointestinal (UGI) tract cancers (head and neck, esophagus, and stomach) are higher among men than among women.

RESULTS: During follow-up through 2003, 162 incident adenocarcinomas (ACs; esophagus, N = 25, and stomach, N = 137) and 353 incident squamous cell carcinomas (SCCs; head and neck, n = 297, and esophagus, N = 56) occurred.

[MeSH-major] Adenocarcinoma / epidemiology. Gastrointestinal Neoplasms / epidemiology. Head and Neck Neoplasms / epidemiology. Menstruation. Reproductive History

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(PMID = 20186831.001).

[ISSN] 0008-543X

[Journal-full-title] Cancer

[ISO-abbreviation] Cancer

[Language] eng

[Grant] United States / Intramural NIH HHS / / Z99 CA999999

[Publication-type] Journal Article; Research Support, N.I.H., Intramural

[Publication-country] United States

[Other-IDs] NLM/ NIHMS161010; NLM/ PMC2836418

   

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METHODS: We tested three key genetic and epigenetic alterations (EGFR, RASSF1A, and BRAF) of this pathway on a series of primary NSCLC (total 111; adenocarcinoma 49, squamous cell carcinoma [SCC] 48, and others 14).

RESULTS: Five EGFR mutations were identified: three in adenocarcinoma (6%), one in SCC (2%), and one in adenocarcinoma with bronchoalveolar component tumor (7%).

Mutations of EGFR, BRAF, and KRAS in adenocarcinoma were mutually exclusive and inversely correlated with RASSF1A methylation (p = -0.394; p = 0.007).

DISCUSSION: Overall, genetic and/or epigenetic alterations of erbB pathway genes were detected in 80% (39/49) of adenocarcinomas.Approximately half of primary adenocarcinoma harbor molecular alterations of the erbB pathway.

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[ErratumIn] J Thorac Oncol. 2011 Feb;6(2):409

(PMID = 21102258.001).

[ISSN] 1556-1380

[Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

[ISO-abbreviation] J Thorac Oncol

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / CA084986-12; United States / NCI NIH HHS / CA / U01 CA084986; United States / NCI NIH HHS / CA / U01 CA084986-12; United States / NCI NIH HHS / CA / U01-CA84986

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / KRAS protein, human; 0 / Oncogene Proteins v-erbB; 0 / Proto-Oncogene Proteins; 0 / RASSF1 protein, human; 0 / Tumor Suppressor Proteins; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / ras Proteins

[Other-IDs] NLM/ NIHMS244223; NLM/ PMC3057519

   

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[Title] Sinonasal clear cell adenocarcinoma: a case report.

We present cytologic findings of clear cell sinonasal adenocarcinoma and related pitfalls.

The mass was reported to be a clear cell neoplasm, and excision of the whole mass was performed.

CONCLUSION: Cytologic findings of this rare tumor overlap with those of salivary gland-type tumors with clear cell change and should be added to the list of head and neck tumors with clear cell change.

[MeSH-major] Adenocarcinoma, Clear Cell / pathology. Nasal Mucosa / pathology. Paranasal Sinus Neoplasms / pathology

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(PMID = 19798893.001).

[ISSN] 0001-5547

[Journal-full-title] Acta cytologica

[ISO-abbreviation] Acta Cytol.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

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[Title] Salivary gland cystadenocarcinoma of the mobile tongue, low-grade papillary adenocarcinoma variant: a case report.

Cystadenocarcinoma is a rare malignant neoplasm of the salivary gland.

Treatment involves local excision; neck dissection and postoperative radiation therapy are used for clinically positive neck metastases.

[MeSH-major] Cystadenocarcinoma, Papillary / diagnosis. Salivary Gland Neoplasms / diagnosis

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(PMID = 17240709.001).

[ISSN] 0145-5613

[Journal-full-title] Ear, nose, & throat journal

[ISO-abbreviation] Ear Nose Throat J

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

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[Title] How we do it: Chemo-electroporation in the head and neck for otherwise untreatable patients.

Keypoints * Chemo-electroporation therapy with bleomycin is a locoregional treatment modality for head and neck and skin cancer, with the potential to preserve function.

* Based on the outcome of the clinical trial, bleomycin-electroporation therapy has the potential to become a valuable addition to the late-stage treatment options for patients with head and neck or skin tumours.

[MeSH-major] Antibiotics, Antineoplastic / therapeutic use. Bleomycin / therapeutic use. Electroporation / methods. Head and Neck Neoplasms / therapy

[MeSH-minor] Adenocarcinoma / secondary. Adenocarcinoma / therapy. Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / secondary. Carcinoma, Basal Cell / therapy. Carcinoma, Merkel Cell / secondary. Carcinoma, Merkel Cell / therapy. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / therapy. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Melanoma / secondary. Melanoma / therapy. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Netherlands. Salivary Gland Neoplasms / secondary. Salivary Gland Neoplasms / therapy. Sarcoma / secondary. Sarcoma / therapy. Skin Neoplasms / secondary. Skin Neoplasms / therapy. Treatment Outcome. Tumor Burden / drug effects

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(PMID = 17014460.001).

[ISSN] 1749-4478

[Journal-full-title] Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

[ISO-abbreviation] Clin Otolaryngol

[Language] eng

[Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 11056-06-7 / Bleomycin

   

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Intralesional administration after surgical debulking delivers the medication directly to the site of disease and is thought to have fewer systemic side effects than intravenous infusion.

It is known to be nephrotoxic when administered intravenously and there remains concern that cidofovir has carcinogenic potential based on animal studies (mammary adenocarcinoma in rats).

[MeSH-minor] Humans. Injections, Intralesional. Neoplasm Recurrence, Local / prevention & control

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(PMID = 18197029.001).

[ISSN] 1531-6998

[Journal-full-title] Current opinion in otolaryngology & head and neck surgery

[ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] United States

[Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antiviral Agents; 0 / Organophosphonates; 8J337D1HZY / Cytosine; JIL713Q00N / cidofovir

[Number-of-references] 30

   

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[Title] Paraneoplastic syndrome in a case of sinonasal adenocarcinoma.

[MeSH-major] Adenocarcinoma / complications. Nasopharyngeal Neoplasms / complications. Nose Neoplasms / complications. Paraneoplastic Syndromes / etiology

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(PMID = 19786233.001).

[ISSN] 1097-6817

[Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

[ISO-abbreviation] Otolaryngol Head Neck Surg

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

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Patients with multiple malignant primary tumours are often described, based on their chronology of presentation, as simultaneous, synchronous or metachronous tumours.

Lung malignancies presenting in association with head and neck tumours are well documented while there have been small series of thyroid synchronous cancers presenting with laryngeal lesions in literature.

We also discuss screening for lung and thyroid malignancies in patients with head and neck squamous cell carcinoma (SCC).

[MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Papillary / diagnosis. Carcinoma, Squamous Cell / diagnosis. Laryngeal Neoplasms / diagnosis. Lung Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Thyroid Neoplasms / diagnosis

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(PMID = 19803306.001).

[ISSN] 0300-5283

[Journal-full-title] The Medical journal of Malaysia

[ISO-abbreviation] Med. J. Malaysia

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Malaysia

   

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[Title] Diagnosis and management of neoplastic lesions of the submandibular triangle.

Review of submandibular triangle neoplasms (benign and malignant) treated at a tertiary referral centre in the United Kingdom (1986-2004).

Forty nine benign and 58 malignant neoplasms of the submandibular triangle were reviewed.

Definitive diagnosis was by excision and pathological examination.

For malignant lesions (n=58), 48 were primary malignancies and 10 metastatic lesions.

The most frequent primary lesions were malignant non-Hodgkin lymphoma (n=22), adenoid cystic carcinoma (n=9) and mucoepidermoid carcinoma (n=9).

The mainstay treatment for both benign and malignant lesions was surgical either by extracapsular excision of the gland/lesion or selective levels I, IIa and III neck dissection.

There is a relatively high incidence of malignant neoplasms in this region (54%).

Malignant tumours have a poor symptomatology that can result in late (often post-operative) diagnosis.

The adequacy of primary surgery is crucial and would support the approach of a more radical excision primarily with a selective levels I, IIa and III neck dissection; ensuring a definitive operation for benign lesions, avoiding the risks of tumour spillage associated with a more limited excision; and removing the primary echelon of lymph nodes at risk of metastasis if the pathology in fact turns out to be malignant; without a significantly higher morbidity in comparison with an extracapsular gland/lesion excision.

[MeSH-major] Mouth Neoplasms / diagnosis

[MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / surgery. Child. Female. Humans. Lymphoma, Non-Hodgkin / diagnosis. Lymphoma, Non-Hodgkin / surgery. Male. Middle Aged. Retrospective Studies. Submandibular Gland Neoplasms / diagnosis. Submandibular Gland Neoplasms / surgery. Treatment Outcome

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(PMID = 17467329.001).

[ISSN] 1368-8375

[Journal-full-title] Oral oncology

[ISO-abbreviation] Oral Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

   

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[Title] Basal cell adenocarcinoma in the tongue: an unusual presentation.

We present a case of basal cell adenocarcinoma (BCAC) in the tongue in a 65-year old male.

The clinicopathological features and the cellular immunophenotype addressed the diagnosis towards BCAC of the tongue.

The goal of this report is to increase awareness of this rare disease and to review and discuss the differential diagnosis and important considerations in treatment.

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(PMID = 21151583.001).

[ISSN] 1179-5549

[Journal-full-title] Clinical Medicine Insights. Oncology

[ISO-abbreviation] Clin Med Insights Oncol

[Language] ENG

[Publication-type] Journal Article

[Publication-country] United States

[Other-IDs] NLM/ PMC2999957

[Keywords] NOTNLM ; basal cell adenocarcinoma / minor salivary gland / tongue

   

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[Title] Genetic and nongenetic covariates of pain severity in patients with adenocarcinoma of the pancreas: assessing the influence of cytokine genes.

We evaluated a series of patients with histologically confirmed adenocarcinoma of the pancreas (n=484), who had completed a self-administered survey of pain before initiating any cancer treatment.

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(PMID = 19692203.001).

[ISSN] 1873-6513

[Journal-full-title] Journal of pain and symptom management

[ISO-abbreviation] J Pain Symptom Manage

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / R03 CA128069; United States / NCI NIH HHS / CA / R03 CA128069-01A2; United States / NCI NIH HHS / CA / CA128069-01A2; United States / NCI NIH HHS / CA / K07 CA109043-05; United States / NCI NIH HHS / CA / CA109043-05; United States / NCI NIH HHS / CA / K07 CA109043; United States / NCI NIH HHS / CA / CA128069; United States / NCI NIH HHS / CA / P20 CA101936; United States / NCI NIH HHS / CA / CA101936; United States / NCI NIH HHS / CA / CA109043

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Analgesics; 0 / Cytokines

[Other-IDs] NLM/ NIHMS131146; NLM/ PMC2795073

   

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We sought to review our experience in cases of two lung lesions or head and neck cancer and lung lesions to determine whether a significantly clinical problem existed, what standard processes were in place to address it, and whether a new diagnostic standard was required.

METHODS: Between January 1, 2007, and October 31, 2008, CMP was used in 24 cases of two lung lesions or a head and neck cancer and lung lesion.

The cases involved two lung lesions (n = 13) or a head and neck cancer and a lung lesion (n = 11).

[MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / genetics. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / genetics. Lung Neoplasms / diagnosis. Lung Neoplasms / genetics. Mutation

[MeSH-minor] Aged. Aged, 80 and over. DNA Fingerprinting. Diagnosis, Differential. Female. Head and Neck Neoplasms / pathology. Humans. Male. Middle Aged. Neoplasms, Multiple Primary / diagnosis. Retrospective Studies

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[Copyright] Copyright 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

[CommentIn] Ann Thorac Surg. 2010 Aug;90(2):397 [20667317.001]

(PMID = 20667316.001).

[ISSN] 1552-6259

[Journal-full-title] The Annals of thoracic surgery

[ISO-abbreviation] Ann. Thorac. Surg.

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] Netherlands

   

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To discover novel tumor suppressor genes (TSGs) silenced by aberrant promoter methylation, we analyzed the gene expression profiles of two lung adenocarcinoma cell lines using pharmacologic-unmasking and subsequent microarray-analysis.

Aberrant methylation was detected in four genes (CRABP2, NOEY2, T, MAP2K3) in at least one lung adenocarcinoma cell lines.

Furthermore, the T promoter was methylated in 60% of primary lung adenocarcinomas versus 13% of non-malignant lung tissues.

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(PMID = 17980147.001).

[ISSN] 1090-2104

[Journal-full-title] Biochemical and biophysical research communications

[ISO-abbreviation] Biochem. Biophys. Res. Commun.

[Language] eng

[Grant] United States / NCI NIH HHS / CA / P50 CA96784-01

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Brachyury protein; 0 / Fetal Proteins; 0 / T-Box Domain Proteins

   

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Nevertheless, the majority of epithelial and salivary malignancies of this region (ie, squamous cell carcinoma, adenocarcinoma, adenoid cystic carcinoma, sinonasal undifferentiated carcinoma, and esthesioneuroblastoma) require surgical intervention as part of any treatment regimen.

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(PMID = 15610711.001).

[ISSN] 1527-2729

[Journal-full-title] Current treatment options in oncology

[ISO-abbreviation] Curr Treat Options Oncol

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] United States

[Number-of-references] 99

   

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[MeSH-major] Carcinoma, Non-Small-Cell Lung / radiotherapy. Gastrointestinal Neoplasms / radiotherapy. Head and Neck Neoplasms / radiotherapy. Liver Neoplasms / radiotherapy. Lung Neoplasms / radiotherapy. Radiotherapy Planning, Computer-Assisted

[MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / radiotherapy. Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / radiotherapy. Dose Fractionation. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Staging. Radiotherapy Dosage. Retrospective Studies. Risk Factors. Survival Rate. Treatment Outcome

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(PMID = 20104193.001).

[ISSN] 1556-1380

[Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

[ISO-abbreviation] J Thorac Oncol

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

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The aim was to assess its expression and prognostic value in salivary gland adenocarcinoma and muco-epidermoid carcinoma.

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[Copyright] © 2010 Blackwell Publishing Limited.

(PMID = 21083600.001).

[ISSN] 1365-2559

[Journal-full-title] Histopathology

[ISO-abbreviation] Histopathology

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins

   

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Immunohistochemistry proved useful for diagnosis in 20 cases.

One patient had an adenocarcinoma and an inverted papilloma associated with neuroendocrine carcinoma.

CONCLUSION: Small cell neuroendocrine carcinoma of the sinonasal tract is an uncommon neoplasm with aggressive clinical behaviour.

[MeSH-minor] Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / therapy. Retrospective Studies. Survival Rate

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(PMID = 16526967.001).

[ISSN] 0022-2151

[Journal-full-title] The Journal of laryngology and otology

[ISO-abbreviation] J Laryngol Otol

[Language] eng

[Publication-type] Journal Article; Multicenter Study

[Publication-country] England

   

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[Title] Versatility of free SCIA/SIEA flaps in head and neck defects.

Reconstruction of head and neck defects may require replacement of the bony structures, external soft tissue, and intraoral mucosa.

Recently, the authors used free superficial circumflex iliac artery/superficial inferior epigastric (SCIA/SIEA) flaps for head and neck reconstruction.

Fifteen patients underwent head and neck reconstruction with free SCIA/SIEA flaps (n = 16).

Based on our results, we believe that the free SCIA/SIEA flap is useful for soft tissue defect reconstruction in the head and neck.

(1) Large flap elevation is possible for reaching distant recipient vessels, (2) Two surgical teams may work at the same time preparing the donor and recipient regions, and (3) The flap design uses an abdominoplasty incision, which has minimal donor site morbidity.

[MeSH-minor] Adenocarcinoma / surgery. Adolescent. Adult. Aged. Bone Transplantation. Burns / surgery. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Child. Cicatrix / surgery. Facial Neoplasms / surgery. Female. Follow-Up Studies. Humans. Male. Maxilla / surgery. Maxillary Neoplasms / surgery. Middle Aged. Neck Injuries / surgery. Neoplasm Recurrence, Local / surgery. Reoperation. Scalp / surgery. Skin Neoplasms / surgery. Young Adult

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(PMID = 20574218.001).

[ISSN] 1536-3708

[Journal-full-title] Annals of plastic surgery

[ISO-abbreviation] Ann Plast Surg

[Language] eng

[Publication-type] Case Reports; Comparative Study; Journal Article

[Publication-country] United States

   

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Two oral and two skin SCC cell lines were used, as well as an endometrial adenocarcinoma cell line.

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(PMID = 20890764.001).

[ISSN] 1432-2307

[Journal-full-title] Virchows Archiv : an international journal of pathology

[ISO-abbreviation] Virchows Arch.

[Language] eng

[Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Germany

[Chemical-registry-number] 0 / Serum Amyloid P-Component; 0 / Vascular Endothelial Growth Factor C

[Other-IDs] NLM/ PMC2995317

   

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Hyalinizing clear cell carcinoma is a rare, low-grade neoplasm of the minor salivary glands.

The treatment of choice is wide excision and selective neck dissection, with or without radiotherapy.

[MeSH-major] Adenocarcinoma, Clear Cell / pathology. Salivary Gland Neoplasms / pathology. Tongue Neoplasms / pathology

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(PMID = 17822882.001).

[ISSN] 0901-5027

[Journal-full-title] International journal of oral and maxillofacial surgery

[ISO-abbreviation] Int J Oral Maxillofac Surg

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Denmark

   

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[Title] Misleading initial histological diagnosis of a polymorphous low-grade adenocarcinoma in situ ex pleomorphic adenoma-a case report.

INTRODUCTION: Polymorphous low-grade adenocarcinoma (PLGA) are frequent tumours of palatinal minor salivary glands.

They appear clinically as solid mass located beneath intact surface epithelium, thus quite similar with benign neoplasm.

The correct aetiology of this disorder is still unknown.

Definitive histological examination of the whole tumour revealed a small malignant fraction of the specimen besides a major part of benign tissue formations (PA).

[MeSH-major] Adenocarcinoma / pathology. Adenoma, Pleomorphic / pathology. Carcinoma in Situ / pathology. Neoplasms, Multiple Primary / pathology. Palatal Neoplasms / pathology

[MeSH-minor] Aged. Biopsy / methods. Diagnosis, Differential. Female. Humans. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology

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(PMID = 19189140.001).

[ISSN] 1865-1550

[Journal-full-title] Oral and maxillofacial surgery

[ISO-abbreviation] Oral Maxillofac Surg

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Germany

   

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[Title] Recommendations for treatment with IMRT for prostate and head-neck cancer. Axencia de Avaliación de Tecnoloxías Sanitarias de Galicia.

In this article we present the basic standards for the IMRT treatment for prostate and head-neck cancer agreed upon a consensus meeting.

[MeSH-major] Adenocarcinoma / radiotherapy. Head and Neck Neoplasms / radiotherapy. Prostatic Neoplasms / radiotherapy. Radiotherapy, Intensity-Modulated

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[Cites] Radiother Oncol. 2000 Jun;55(3):241-9 [10869739.001]

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(PMID = 16648101.001).

[ISSN] 1699-048X

[Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

[ISO-abbreviation] Clin Transl Oncol

[Language] eng

[Publication-type] Journal Article; Practice Guideline

[Publication-country] Italy

   

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[Title] Applications of ultrasonography in the diagnosis of soft tissue swellings of the cervicofacial region.

PURPOSE: To determine the accuracy, sensitivity, specificity and prediction values of ultrasound as a means of diagnosis of cervico-facial soft tissue swellings.

The accuracy of ultrasound in the diagnosis of pleomorphic adenoma was 80% and 100% for both adenocarcinoma and hemangioma.

The sensitivity of ultrasound in the diagnosis of pleomorphic adenoma was 80% and 100% for adenocarcinoma, hemangioma, all the cysts and HIV associated swellings.

Ultrasound was also 100% specific in the diagnosis of monomorphic adenoma and hemangioma.

The accuracy of diagnosis is enhanced by the characteristics of the probe and the experience of the sonologist.

[MeSH-major] Head and Neck Neoplasms / ultrasonography. Soft Tissue Neoplasms / ultrasonography

[MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Cysts / ultrasonography. Diagnosis, Differential. Female. Hamartoma / ultrasonography. Humans. Infant. Infant, Newborn. Male. Middle Aged. Predictive Value of Tests. Sensitivity and Specificity

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(PMID = 16918181.001).

[ISSN] 0189-160X

[Journal-full-title] West African journal of medicine

[ISO-abbreviation] West Afr J Med

[Language] eng

[Publication-type] Journal Article

[Publication-country] Nigeria

   

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Histopathological study showed poorly-differentiated adenocarcinoma in both stomach and supraclavicular lymph node.

However, gastric endoscopic biopsy still showed a remnant malignant lesion.

[MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cisplatin / therapeutic use. Head / pathology. Lentinan / therapeutic use. Neck / pathology. Oxonic Acid / therapeutic use. Stomach Neoplasms / drug therapy. Tegafur / therapeutic use

[MeSH-minor] Aged. Drug Combinations. Female. Gastroscopy. Humans. Lymphatic Metastasis. Neoplasm Staging. Positron-Emission Tomography. Tomography, X-Ray Computed

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(PMID = 20414031.001).

[ISSN] 0385-0684

[Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy

[ISO-abbreviation] Gan To Kagaku Ryoho

[Language] jpn

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Japan

[Chemical-registry-number] 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 37339-90-5 / Lentinan; 5VT6420TIG / Oxonic Acid; Q20Q21Q62J / Cisplatin

   

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[Title] The oral cavity as a molecular mirror of lung carcinogenesis.

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COS Scholar Universe. author profiles.

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[CommentOn] Cancer Prev Res (Phila). 2008 Jun;1(1):39-44 [19138934.001]

(PMID = 19138931.001).

[ISSN] 1940-6215

[Journal-full-title] Cancer prevention research (Philadelphia, Pa.)

[ISO-abbreviation] Cancer Prev Res (Phila)

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / 5U01 CA084986; United States / NIDCR NIH HHS / DE / P50 DE019032; United States / NIDCR NIH HHS / DE / R37 DE012588; United States / NIDCR NIH HHS / DE / R01 DE012588; United States / NCI NIH HHS / CA / U01 CA084986

[Publication-type] Comment; Journal Article; Research Support, N.I.H., Extramural

[Publication-country] United States

[Other-IDs] NLM/ NIHMS695561; NLM/ PMC4604561

   

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[Title] Methylation of SOCS-3 and SOCS-1 in the carcinogenesis of Barrett's adenocarcinoma.

BACKGROUND: The suppressors of cytokine signalling (SOCS) are inhibitors of cytokine signalling; methylation of SOCS-3 has been implicated in the tumorigenesis of liver as well as head and neck cancer.

AIMS: This study was performed to elucidate the role of SOCS-1 and SOCS-3 in Barrett's adenocarcinoma and its precursor lesions.

CONCLUSIONS: These data indicate that promoter methylation and subsequent transcript downregulation of SOCS-3 transcripts and, to a much lesser extent, SOCS-1 are involved in the multistep carcinogenesis of Barrett's adenocarcinoma.

[MeSH-major] Adenocarcinoma / genetics. Barrett Esophagus / genetics. Esophageal Neoplasms / genetics. Suppressor of Cytokine Signaling Proteins / genetics

[MeSH-minor] Carcinoma in Situ / genetics. Carcinoma, Squamous Cell / genetics. Cell Line, Tumor. CpG Islands / genetics. DNA, Neoplasm / genetics. Humans. Methylation. Neoplasm Proteins / genetics. Promoter Regions, Genetic / genetics. Transcription, Genetic / genetics

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(PMID = 17376806.001).

[ISSN] 0017-5749

[Journal-full-title] Gut

[ISO-abbreviation] Gut

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Neoplasm Proteins; 0 / SOCS1 protein, human; 0 / SOCS3 protein, human; 0 / Suppressor of Cytokine Signaling Proteins

[Other-IDs] NLM/ PMC1955493

   

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[Title] Role of radiotherapy in the treatment of nasoethmoidal adenocarcinoma.

OBJECTIVE: To assess the efficacy of radiotherapy in the treatment of nasoethmoidal adenocarcinoma.

PATIENTS: The medical records of 418 patients who presented with nasoethmoidal adenocarcinoma from January 1, 1976, through December 31, 2001, were evaluated.

CONCLUSION: The results of this retrospective study suggest that radiotherapy can be used to treat nasoethmoidal adenocarcinoma, but its usefulness should be confirmed with further prospective studies.

[MeSH-major] Adenocarcinoma / radiotherapy. Ethmoid Bone. Paranasal Sinus Neoplasms / radiotherapy. Skull Neoplasms / radiotherapy

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(PMID = 20157059.001).

[ISSN] 1538-361X

[Journal-full-title] Archives of otolaryngology--head & neck surgery

[ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

   

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Histological classification included squamous cell carcinoma in 6, adenocarcinoma in 8, adenoidcystic carcinoma in 20 and melanoma in 8 patients, respectively.

Six patients had been treated with RT during initial therapy after primary diagnosis, and IMRT was performed for the treatment of tumor progression as re-irradiation.

[MeSH-minor] Adenocarcinoma / mortality. Adenocarcinoma / radiotherapy. Carcinoma, Adenoid Cystic / mortality. Carcinoma, Adenoid Cystic / radiotherapy. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / radiotherapy. Female. Humans. Male. Melanoma / radiotherapy. Radiotherapy Dosage. Radiotherapy Planning, Computer-Assisted / methods. Treatment Outcome

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(PMID = 16859556.001).

[ISSN] 1748-717X

[Journal-full-title] Radiation oncology (London, England)

[ISO-abbreviation] Radiat Oncol

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Other-IDs] NLM/ PMC1557519

[General-notes] NLM/ Original DateCompleted: 20070720