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6. Balm AJ, van Velthuysen ML, Hoebers FJ, Vogel WV, van den Brekel MW: Diagnosis and treatment of a neck node swelling suspicious for a malignancy: an algorithmic approach. Int J Surg Oncol; 2010;2010:581540
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnosis and treatment of a neck node swelling suspicious for a malignancy: an algorithmic approach.
  • Aim. To present an up-to-date algorithm incorporating recent advances regarding its diagnosis and treatment.
  • The vast majority of neck nodes from occult primaries (>90%) represent SCC with a high incidence among middle aged man.
  • Asiatic and North African patients with neck node metastases are at risk of harbouring an occult nasopharyngeal carcinoma.
  • The remainder are adenocarcinoma, undifferentiated carcinoma, melanoma, thyroid carcinoma and Merkel cell carcinoma.
  • FDG-PET/CT has proven to be helpful in identifying occult primary carcinomas of the head and neck, especially when applied as a guiding tool prior to panendoscopy, and may induce treatment related clinical decisions in up to 60% of cases.

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  • (PMID = 22312490.001).
  • [ISSN] 2090-1402
  • [Journal-full-title] International journal of surgical oncology
  • [ISO-abbreviation] Int J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3265261
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7. Shimane T, Mori T, Ono T, Egawa S, Furuta A, Ikeda K, Kamakazu K, Kobayashi S, Sanbe T, Suzaki H: [Three cases of adenocarcinoma of the head and neck maintaining QOL by administration of docetaxel]. Gan To Kagaku Ryoho; 2010 Dec;37(13):2897-900
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  • [Title] [Three cases of adenocarcinoma of the head and neck maintaining QOL by administration of docetaxel].
  • A primary head and neck adenocarcinoma is a comparatively rare disease, and surgical resection has been the first choice for its treatment.
  • In the present study, we performed chemotherapy with weekly administration of docetaxel in 3 cases with unresectable or recurrent adenocarcinoma of the head and neck on an outpatient basis, resulting in long-term maintenance of the patients' QOL.
  • The present results might suggest that it is possible to treat patients with adenocarcinoma in the head and neck without decreasing patients' QOL.
  • [MeSH-major] Adenocarcinoma / drug therapy. Head and Neck Neoplasms / drug therapy. Taxoids / administration & dosage

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  • (PMID = 21160265.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Taxoids; 15H5577CQD / docetaxel
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8. Tsukahara K, Kawabata K, Mitani H, Yoshimoto S, Sugitani I, Yonekawa H, Beppu T, Fukushima H, Sasaki T: Three cases of bilateral chylothorax developing after neck dissection. Auris Nasus Larynx; 2007 Dec;34(4):573-6
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  • [Title] Three cases of bilateral chylothorax developing after neck dissection.
  • Only 16 cases of bilateral chylothorax following neck dissection have been reported within 10 decades.
  • In this paper, three cases of bilateral chylothorax which developed after neck dissection are reported.
  • Diagnosis may be delayed in those who are on total parenteral nutrition, and therefore particular attention should be paid to those patients.
  • It may be difficult to treat cases of chylothorax that develop following neck dissection performed after radiotherapy.
  • [MeSH-major] Adenocarcinoma, Papillary / surgery. Chylothorax / etiology. Laryngeal Neoplasms / surgery. Neck Dissection / adverse effects. Postoperative Complications / etiology. Thyroid Neoplasms / surgery. Tongue Neoplasms / surgery
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Ligation. Male. Middle Aged. Neoplasm Staging. Parenteral Nutrition, Total. Thoracic Duct / surgery. Thoracostomy

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  • (PMID = 17466474.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 20
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9. Schmalbach CE, Miller FR: Occult primary head and neck carcinoma. Curr Oncol Rep; 2007 Mar;9(2):139-46
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  • [Title] Occult primary head and neck carcinoma.
  • Unknown primary carcinoma presenting as cervical lymph node metastasis accounts for approximately 5% of all head and neck malignancies.
  • The typical presentation involves a middle-aged man with a painless neck mass that has been present for several months.
  • The remainder are comprised of adenocarcinoma, melanoma, and other rare histologic variants.
  • The ability to identify the occult primary tumor is imperative because identification allows site-specific therapy and avoidance of wide-field radiation side effects.
  • Following confirmation of metastatic cervical disease with fine-needle aspiration, all patients presenting with an unknown primary carcinoma require a thorough head and neck history and physical examination, radiographic imaging, panendoscopy with directed biopsies of Waldeyer's ring, and bilateral tonsillectomy.
  • Positron emission tomography has proved helpful in identifying occult primary tumors of the head and neck region.
  • [MeSH-major] Head and Neck Neoplasms / secondary. Neoplasms, Unknown Primary / pathology

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  • (PMID = 17288881.001).
  • [ISSN] 1523-3790
  • [Journal-full-title] Current oncology reports
  • [ISO-abbreviation] Curr Oncol Rep
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 27
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10. Kariya S, Kosaka M, Orita Y, Akagi H, Nishizaki K: Adenocarcinoma ex pleomorphic adenoma of the head and neck: Report of five cases. Auris Nasus Larynx; 2006 Mar;33(1):43-6
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  • [Title] Adenocarcinoma ex pleomorphic adenoma of the head and neck: Report of five cases.
  • OBJECTIVE: Adenocarcinoma ex pleomorphic adenoma is a rare tumor, and thus the management of the tumor has not been established.
  • RESULTS: We present five cases of adenocarcinoma ex pleomorphic adenoma of the head and neck, including a rare case with nasopharyngeal adenocarcinoma ex pleomorphic adenoma.
  • There was no response to chemotherapy with nedaplatin and 5-FU, but the nasopharyngeal adenocarcinoma ex pleomorphic adenoma showed a remarkable regression after the administration of docetaxel.
  • CONCLUSION: The combination therapy that includes docetaxel may be a promising treatment for adenocarcinoma ex pleomorphic adenoma of the head and neck.

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  • (PMID = 16168590.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 0 / Taxoids; 15H5577CQD / docetaxel; 8UQ3W6JXAN / nedaplatin; U3P01618RT / Fluorouracil
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11. Nasir S, Aydin MA: Versatility of free SCIA/SIEA flaps in head and neck defects. Ann Plast Surg; 2010 Jul;65(1):32-7
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  • [Title] Versatility of free SCIA/SIEA flaps in head and neck defects.
  • Reconstruction of head and neck defects may require replacement of the bony structures, external soft tissue, and intraoral mucosa.
  • Recently, the authors used free superficial circumflex iliac artery/superficial inferior epigastric (SCIA/SIEA) flaps for head and neck reconstruction.
  • Fifteen patients underwent head and neck reconstruction with free SCIA/SIEA flaps (n = 16).
  • Based on our results, we believe that the free SCIA/SIEA flap is useful for soft tissue defect reconstruction in the head and neck.
  • (1) Large flap elevation is possible for reaching distant recipient vessels, (2) Two surgical teams may work at the same time preparing the donor and recipient regions, and (3) The flap design uses an abdominoplasty incision, which has minimal donor site morbidity.
  • [MeSH-minor] Adenocarcinoma / surgery. Adolescent. Adult. Aged. Bone Transplantation. Burns / surgery. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Child. Cicatrix / surgery. Facial Neoplasms / surgery. Female. Follow-Up Studies. Humans. Male. Maxilla / surgery. Maxillary Neoplasms / surgery. Middle Aged. Neck Injuries / surgery. Neoplasm Recurrence, Local / surgery. Reoperation. Scalp / surgery. Skin Neoplasms / surgery. Young Adult

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  • (PMID = 20574218.001).
  • [ISSN] 1536-3708
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] United States
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12. Chen F, Sonobe M, Sato K, Fujinaga T, Shoji T, Sakai H, Miyahara R, Bando T, Okubo K, Hirata T, Date H: Pulmonary resection for metastatic head and neck cancer. World J Surg; 2008 Aug;32(8):1657-62
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  • [Title] Pulmonary resection for metastatic head and neck cancer.
  • BACKGROUND: Pulmonary metastasectomy has become the standard therapy for various metastatic malignancies to the lungs; however, little data have been available about lung metastasectomy for head and neck cancers.
  • METHODS: Between 1991 and 2007, 20 patients with pulmonary metastases from head and neck cancers underwent complete pulmonary resection.
  • All patients had obtained or had obtainable locoregional control of their primary head and neck cancers.
  • The median disease-free interval from the time of treatment of the head and neck primary cancers to the development of pulmonary metastases was 27 months.
  • CONCLUSION: The current practice of pulmonary metastasectomy for head and neck cancers in our institution was well justified.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / surgery. Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / surgery. Head and Neck Neoplasms / pathology. Lung Neoplasms / secondary. Lung Neoplasms / surgery

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  • (PMID = 18553194.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Conti C, Ferraris P, Garavaglia M, Giorgini E, Rubini C, Sabbatini S, Tosi G: Microimaging FTIR of head and neck tumors. IV. Microsc Res Tech; 2009 Feb;72(2):67-75
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  • [Title] Microimaging FTIR of head and neck tumors. IV.
  • On continuing our studies on head and neck neoplasia, specimens from salivary gland tumors have been explored by using infrared microimaging spectroscopy to discern healthy from neoplastic tissues.
  • Samples with Warthin tumor, epithelial displasia, marginal B-cell lymphoma, low-grade adenocarcinoma, and adenoid cystic carcinoma pathologies have been investigated by using conventional light sources.

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18825780.001).
  • [ISSN] 1097-0029
  • [Journal-full-title] Microscopy research and technique
  • [ISO-abbreviation] Microsc. Res. Tech.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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4. Biel MA: Photodynamic therapy of head and neck cancers. Methods Mol Biol; 2010;635:281-93
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  • [Title] Photodynamic therapy of head and neck cancers.
  • Over 1,500 patients have been treated with PDT using Photofrin, HPD, ALA, or Foscan for head and neck cancers.
  • The predominant histology is squamous cell carcinoma, but other histologies treated include mucosal melanoma, Kaposi's sarcoma, adenocarcinoma, metastatic breast carcinoma, and adenoid cystic carcinoma.
  • Several multi-institutional phase II clinical trials evaluating PDT treatment of head and neck cancers have demonstrated the efficacy of this minimally invasive therapy in the treatment of early oropharyngeal primary and recurrent cancers as well as the palliative treatment of refractory head and neck cancers.
  • Photodynamic therapy is as effective as conventional therapies for the treatment of early (Cis, T1, T2) squamous cell cancers of the head and neck.
  • [MeSH-major] Head and Neck Neoplasms / drug therapy. Photochemotherapy

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  • (PMID = 20552353.001).
  • [ISSN] 1940-6029
  • [Journal-full-title] Methods in molecular biology (Clifton, N.J.)
  • [ISO-abbreviation] Methods Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Tijink BM, De Bree R, Van Dongen GA, Leemans CR: How we do it: Chemo-electroporation in the head and neck for otherwise untreatable patients. Clin Otolaryngol; 2006 Oct;31(5):447-51
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  • [Title] How we do it: Chemo-electroporation in the head and neck for otherwise untreatable patients.
  • Keypoints * Chemo-electroporation therapy with bleomycin is a locoregional treatment modality for head and neck and skin cancer, with the potential to preserve function.
  • * Based on the outcome of the clinical trial, bleomycin-electroporation therapy has the potential to become a valuable addition to the late-stage treatment options for patients with head and neck or skin tumours.
  • [MeSH-major] Antibiotics, Antineoplastic / therapeutic use. Bleomycin / therapeutic use. Electroporation / methods. Head and Neck Neoplasms / therapy
  • [MeSH-minor] Adenocarcinoma / secondary. Adenocarcinoma / therapy. Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / secondary. Carcinoma, Basal Cell / therapy. Carcinoma, Merkel Cell / secondary. Carcinoma, Merkel Cell / therapy. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / therapy. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Melanoma / secondary. Melanoma / therapy. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Netherlands. Salivary Gland Neoplasms / secondary. Salivary Gland Neoplasms / therapy. Sarcoma / secondary. Sarcoma / therapy. Skin Neoplasms / secondary. Skin Neoplasms / therapy. Treatment Outcome. Tumor Burden / drug effects

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  • (PMID = 17014460.001).
  • [ISSN] 1749-4478
  • [Journal-full-title] Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • [ISO-abbreviation] Clin Otolaryngol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 11056-06-7 / Bleomycin
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16. Hertel V, Bozzato A, Alexiou C: [Unilateral neck mass, dysphagia and dyspnea]. HNO; 2010 Aug;58(8):818-22
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  • [Title] [Unilateral neck mass, dysphagia and dyspnea].
  • Extraocular sebaceous carcinoma is a rare malignant tumor, arising from skin and salivary glands.
  • An important differential diagnosis in the head and neck region is metastasizing squamous cell carcinoma.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Deglutition Disorders / etiology. Dyspnea / etiology. Head and Neck Neoplasms / diagnosis. Hypopharyngeal Neoplasms / diagnosis. Sebaceous Gland Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biopsy. Diagnosis, Differential. Endoscopy. Humans. Keratin-5 / analysis. Male. Pyriform Sinus / pathology. Pyriform Sinus / surgery. Surgical Flaps. Tomography, X-Ray Computed. Tracheotomy. Ultrasonography


17. Goel R, Chen E, Welch S, Laurie S, Siu L, Jonker D, Srinivasan R, Wang L, Ivy P, Oza A, Princess Margaret Hospital Phase II Consortium: Phase I study of E7389/gemcitabine combination in patients with advanced solid tumors. J Clin Oncol; 2009 May 20;27(15_suppl):e13509

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  • RESULTS: Patient characteristics: male 11/female 10; median age 59 (range 28-84); performance status 0 /1/2: n=1/13/7; prior chemotherapy 21, prior radiotherapy 7, prior immunotherapy 1; tumour types: ovarian cancer 3, endometrial cancer 3, NSCLC 3, gastric/esophageal adenocarcinoma 3, miscellaneous 9.
  • RESPONSE: partial response 1 (ovarian cancer), stable 8 [minor response 4 (NSCLC 2, endometrial cancer 1, head and neck cancer 1)], progression 8, inevaluable 4.

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  • (PMID = 27961270.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Ruhstaller T, Pless M, Schuller JC, Kranzbühler H, von Moos R, Moosmann P, Rauch D, Montemurro M, Schneider PM, Hess V: Cetuximab in combination with chemoradiotherapy prior to surgery in patients with resectable, locally advanced esophageal carcinoma: A prospective, multicenter phase lb-ll trial of the Swiss Group for Clinical Cancer Research (SAKK 75/06). J Clin Oncol; 2009 May 20;27(15_suppl):4570

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  • : 4570 Background: Cetuximab significantly enhances efficacy of radiotherapy and chemotherapy in head and neck cancer.
  • METHODS: Pts with resectable, locally advanced squamous cell carcinoma (SCC) or adenocarcinoma (AC) of the thoracic esophagus or gastroesophageal junction (staged by EUS, CT and PET scan) were treated with 2 cycles of induction chemotherapy (docetaxel 75mg/m2, cisplatin 75mg/m2 q3w and weekly cetuximab 250mg/m2), followed by concomitant chemo- immuno-radiation therapy (CIRT: docetaxel 20mg/m2, cisplatin 25mg/m2 and cetuximab 250mg/m2 weekly five times concomitant with 45 Gy radiotherapy in 25 fractions); followed by surgery 4-8 weeks later.

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  • (PMID = 27963079.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Sheahan P, Toner M, Timon CV: Clinicopathological features of head and neck adenosquamous carcinoma. ORL J Otorhinolaryngol Relat Spec; 2005;67(1):10-5
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  • [Title] Clinicopathological features of head and neck adenosquamous carcinoma.
  • Adenosquamous carcinoma is a rare tumour which is characterized pathologically by the simultaneous presence of distinct areas of squamous cell carcinoma and adenocarcinoma.
  • In the present study, the medical and pathological records of 4 patients with head and neck adenosquamous carcinoma are reviewed.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Head and Neck Neoplasms / pathology

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  • [Copyright] Copyright (c) 2005 S. Karger AG, Basel.
  • (PMID = 15637416.001).
  • [ISSN] 0301-1569
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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20. Geurts TW, Klomp HM, Burgers SA, van Tinteren H, Roukema BY, Balm AJ: Resection of secondary pulmonary malignancies in head and neck cancer patients. J Laryngol Otol; 2010 Dec;124(12):1278-83
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  • [Title] Resection of secondary pulmonary malignancies in head and neck cancer patients.
  • BACKGROUND: This study aimed to evaluate a single institute's experience with resection of metachronous pulmonary malignancy in patients treated for squamous cell carcinoma of the head and neck.
  • METHODS: Sixty-three consecutive patients treated curatively for head and neck squamous cell carcinoma underwent surgical resection of malignant lung lesions.
  • For patients with pulmonary squamous cell carcinoma (n = 52), the three-year survival rate was 35 per cent (95 per cent confidence interval, 22-48); for patients with resected adenocarcinoma (n = 10), it was 50 per cent (95 per cent confidence interval, 18-75).
  • CONCLUSION: In patients treated curatively for head and neck squamous cell carcinoma, resection of secondary pulmonary cancer is associated with favourable long term overall survival, especially for patients with adenocarcinoma lesions.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Head and Neck Neoplasms / surgery. Lung Neoplasms / surgery. Neoplasms, Second Primary / surgery
  • [MeSH-minor] Adenocarcinoma / mortality. Adenocarcinoma / surgery. Adult. Aged. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Prognosis. Survival Rate. Treatment Outcome

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  • (PMID = 20519045.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] Adenocarcinoma of lung
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26. Sato T, Indo H, Kawabata Y, Kobayashi T, Suenaga S, Iwashita Y, Nitta T, Sugihara K, Majima HJ: Thallium-201 chloride (Tl-201) accumulation and Na+/K+-ATPase expression in tumours of the head and neck. Dentomaxillofac Radiol; 2005 Jul;34(4):212-7
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  • [Title] Thallium-201 chloride (Tl-201) accumulation and Na+/K+-ATPase expression in tumours of the head and neck.
  • OBJECTIVES: The purpose of this report was to evaluate the relationship between the tumour retention index of thallium-201 chloride (Tl-201) scintigraphy and the Na+/K+-ATPase expression in tumours of the head and neck.
  • METHODS: Tl-201 scintigraphy was performed in 146 patients (129 with malignant tumours, ten with benign tumours and seven with inflammation).
  • The Na+/K+-ATPase expression was evaluated immunohistochemically in 61 of 129 patients with malignant tumour.
  • [MeSH-major] Head and Neck Neoplasms / radionuclide imaging. Radiopharmaceuticals. Sodium-Potassium-Exchanging ATPase / analysis. Thallium. Thallium Radioisotopes
  • [MeSH-minor] Adenocarcinoma / enzymology. Adenocarcinoma / pathology. Adenocarcinoma / radionuclide imaging. Adenolymphoma / enzymology. Adenolymphoma / pathology. Adenolymphoma / radionuclide imaging. Adenoma, Pleomorphic / enzymology. Adenoma, Pleomorphic / pathology. Adenoma, Pleomorphic / radionuclide imaging. Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / enzymology. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / radionuclide imaging. Female. Gene Expression Regulation, Enzymologic. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 15961594.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0 / Thallium Radioisotopes; 7791-12-0 / thallium chloride; AD84R52XLF / Thallium; EC 3.6.3.9 / Sodium-Potassium-Exchanging ATPase
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27. Maceira Rozas Mdel C, Rey Liste T, García Caeiro AL, García Comesaña J: Recommendations for treatment with IMRT for prostate and head-neck cancer. Axencia de Avaliación de Tecnoloxías Sanitarias de Galicia. Clin Transl Oncol; 2006 Apr;8(4):262-5
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  • [Title] Recommendations for treatment with IMRT for prostate and head-neck cancer. Axencia de Avaliación de Tecnoloxías Sanitarias de Galicia.
  • In this article we present the basic standards for the IMRT treatment for prostate and head-neck cancer agreed upon a consensus meeting.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Head and Neck Neoplasms / radiotherapy. Prostatic Neoplasms / radiotherapy. Radiotherapy, Intensity-Modulated

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  • (PMID = 16648101.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Practice Guideline
  • [Publication-country] Spain
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28. Yamashita Y, Ishiguro Y, Sano D, Kimura M, Fujita K, Yoshida T, Horiuchi C, Taguchi T, Matsuda H, Mikami Y, Tsukuda M: Antitumor effects of Nafamostat mesilate on head and neck squamous cell carcinoma. Auris Nasus Larynx; 2007 Dec;34(4):487-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Antitumor effects of Nafamostat mesilate on head and neck squamous cell carcinoma.
  • OBJECTIVE: Nafamostat mesilate (FUT-175), a synthetic serine protease inhibitor, has antitumor activities toward adenocarcinoma, e.g., colon cancer.
  • We investigated the biological activities of Nafamostat mesilate on cell proliferation, cell-invasive potential and growth factor production in head and neck squamous cell carcinoma (HNSCC).
  • [MeSH-minor] Cell Line, Tumor. Dose-Response Relationship, Drug. Down-Regulation / drug effects. Female. Gene Expression Regulation, Neoplastic / drug effects. Humans. In Vitro Techniques. Male. Matrix Metalloproteinase 2 / genetics. Matrix Metalloproteinase 9 / genetics. Neoplasm Invasiveness / genetics. RNA, Messenger / genetics. Reverse Transcriptase Polymerase Chain Reaction. Vulvar Neoplasms / pathology

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  • (PMID = 17337140.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Guanidines; 0 / RNA, Messenger; 0 / Transforming Growth Factor beta1; 0 / Vascular Endothelial Growth Factor A; EC 3.4.24.24 / MMP2 protein, human; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9; Y25LQ0H97D / nafamostat
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29. Schrepfer T, Haerle SK, Strobel K, Schaefer N, Hälg RA, Huber GF: The value of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography for staging of primary extranodal head and neck lymphomas. Laryngoscope; 2010 May;120(5):937-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The value of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography for staging of primary extranodal head and neck lymphomas.
  • OBJECTIVES/HYPOTHESIS: Using a retrospective approach, the aim of this study was to confirm the previously described value of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG-PET/CT) in patients with primary extranodal lymphoma of the head and neck region.
  • METHODS: Twenty-six patients with a primary extranodal head and neck lymphoma (22 diffuse large B-cell lymphoma, one Hodgkin's lymphoma, three malignant T-cell lymphomas) were included.
  • In one patient, relevant fluorodeoxyglucose (FDG) uptake within the intestine revealed a cecal adenocarcinoma as a secondary primary.
  • [MeSH-minor] Adenocarcinoma / mortality. Adenocarcinoma / pathology. Adenocarcinoma / radionuclide imaging. Adult. Aged. Aged, 80 and over. Cecal Neoplasms / mortality. Cecal Neoplasms / pathology. Cecal Neoplasms / radionuclide imaging. Female. Fluorodeoxyglucose F18. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Neoplasms, Second Primary / mortality. Neoplasms, Second Primary / pathology. Neoplasms, Second Primary / radionuclide imaging. Radiopharmaceuticals. Retrospective Studies

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  • (PMID = 20422687.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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30. Cannon T, Couch M, Yin X, Guttridge D, Lai V, Shores C: Comparison of animal models for head and neck cancer cachexia. Laryngoscope; 2007 Dec;117(12):2152-8
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  • [Title] Comparison of animal models for head and neck cancer cachexia.
  • METHODS: We established two xenograft models in athymic mice and compared these with a cachexigenic cell line, the murine adenocarcinoma 16 (MAC16) cell line.
  • Eight-week-old female, athymic mice were injected with human head and neck cell lines (JHU022, JHU012) and the MAC16 cell line.
  • [MeSH-major] Adenocarcinoma / complications. Cachexia / etiology. Head and Neck Neoplasms / complications
  • [MeSH-minor] Animals. Blotting, Western. Body Composition. Cell Line, Tumor. Cytokines / biosynthesis. Cytokines / blood. Disease Progression. Female. Humans. Mice. Mice, Nude. Neoplasm Proteins / biosynthesis. Neoplasm Transplantation. Neoplasms, Experimental. Transplantation, Heterologous

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  • (PMID = 17921906.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK056350; United States / NCRR NIH HHS / RR / RR00046
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cytokines; 0 / Neoplasm Proteins
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31. Dutsch-Wicherek M, Popiela TJ, Klimek M, Rudnicka-Sosin L, Wicherek L, Oudinet JP, Skladzien J, Tomaszewska R: Metallothionein stroma reaction in tumor adjacent healthy tissue in head and neck squamous cell carcinoma and breast adenocarcinoma. Neuro Endocrinol Lett; 2005 Oct;26(5):567-74
MedlinePlus Health Information. consumer health - Head and Neck Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metallothionein stroma reaction in tumor adjacent healthy tissue in head and neck squamous cell carcinoma and breast adenocarcinoma.
  • The aim of our study was to evaluate the MT expression in head and neck squamous cells carcinoma and breast adenocarcinoma and their histologically healthy adjacent tissue.
  • MATERIALS AND METHODS: We have sampled 29 tissue samples in total derived from head and neck cancers and 29 samples of their clear surgical margins, 33 breast adenocarcinomas and 33 clear surgical margins.
  • RESULTS: MT expression was revealed in 85,7% of head and neck cancers and 94% of breast adenocarcinomas.
  • MT expression was statistically significantly higher in tumor adjacent tissue than in cancer tissue in cases with the presence of lymph node metastases in both, breast adenocarcinoma and head and neck squamous cell carcinoma.
  • [MeSH-major] Adenocarcinoma / metabolism. Breast Neoplasms / metabolism. Carcinoma, Squamous Cell / metabolism. Head and Neck Neoplasms / metabolism. Metallothionein / metabolism

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  • (PMID = 16264399.001).
  • [ISSN] 0172-780X
  • [Journal-full-title] Neuro endocrinology letters
  • [ISO-abbreviation] Neuro Endocrinol. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Sweden
  • [Chemical-registry-number] 9038-94-2 / Metallothionein
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32. Zhang B, Yan DG, An CM, Xu ZG, Tang PZ: [Application of an extended collar incision in neck dissection for differentiated thyroid cancer]. Zhonghua Zhong Liu Za Zhi; 2009 Mar;31(3):223-5
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  • [Title] [Application of an extended collar incision in neck dissection for differentiated thyroid cancer].
  • OBJECTIVE: To explore a cosmetic incision in the neck dissection for differentiated thyroid carcinoma.
  • METHODS: An extended collar incision was used for neck dissection in 82 consecutive patients with thyroid carcinoma from May 1999 to December 2006.
  • Ninety-six procedures of neck dissection were performed in 82 patients, including one radical neck dissection, one type I modified neck dissection, 8 type II modified neck dissections, and 86 type III modified neck dissections.
  • Eight patients (9.8%) developed complications related to neck dissection.
  • CONCLUSION: It is feasible to perform a modified neck dissection for differentiated thyroid cancer through the extended collar incision.
  • [MeSH-major] Adenocarcinoma, Papillary / surgery. Neck Dissection / methods. Thyroid Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma, Follicular / pathology. Adenocarcinoma, Follicular / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Follow-Up Studies. Humans. Hypocalcemia / etiology. Lymphatic Metastasis. Male. Middle Aged. Young Adult

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  • (PMID = 19615266.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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33. Wang XW, Ni DF: [Investigation of the characters of cervical lymph node metastases of primary malignant tumor beyond head and neck]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2007 Jun;42(6):413-6

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  • [Title] [Investigation of the characters of cervical lymph node metastases of primary malignant tumor beyond head and neck].
  • OBJECTIVE: To investigate the characters of cervical lymph node metastases of primary tumors beyond head and neck.
  • METHODS: Among 466 cases of malignant tumor with cervical lymph node metastases treated in Peking Union Medical College Hospital from January 1989 to June 2004, 77 cases of tumor which sites primarily beyond head and neck were studied.
  • RESULTS: The primary sites of these 77 cases of malignant tumor consisted of lung, stomach, esophagus, galactophore, colon, mediastinum, ovary, uterus, pancreas, liver, mesentery, adrenal gland and rectum.
  • The proportion of the metastases of malignant tumor from primary site beyond head and neck in each region was 2.1% in LEVEL I, 3.7% in LEVEL III, 14.3% in LEVEL IV, 70.8% in LEVEL V.
  • Among the cervical lymph node metastases of primary tumor beyond head and neck, 51.9% were low-grade adenocarcinoma, 15.6% were medial-grade adenocarcinoma, 11.7% were low-grade squamous cell carcinoma, 10.4% were medial-grade squamous carcinoma.
  • CONCLUSIONS: The cervical lymph node metastases of malignant tumor might be seen from many organs beyond head and neck.
  • The metastases from primary sites beyond head and neck usually focus on LEVEL V (81.8%), especially in the left.
  • And the primary tumors beyond head and neck metastasis in this region were more than the tumors from head and neck locally.
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neck. Retrospective Studies. Young Adult

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  • (PMID = 17702413.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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34. Winter H, Meimarakis G, Hoffmann G, Hummel M, Rüttinger D, Zilbauer A, Stelter K, Spelsberg F, Jauch KW, Hatz R, Löhe F: Does surgical resection of pulmonary metastases of head and neck cancer improve survival? Ann Surg Oncol; 2008 Oct;15(10):2915-26
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  • [Title] Does surgical resection of pulmonary metastases of head and neck cancer improve survival?
  • BACKGROUND: The prognosis of patients with metastasized head and neck cancer is poor.
  • Limited experience exists with the benefit of resection of lung metastases and systematic mediastinal and hilar lymph node dissection on survival of patients with head and neck carcinoma.
  • METHODS: Eighty patients undergoing metastasectomy for pulmonary metastases of primary head and neck cancer entered the study.
  • RESULTS: From 1984 until 2006, pulmonary metastases were diagnosed in 332 patients treated for head and neck cancer; 80 of these were admitted to our department for resection.
  • Metastases of the primary head and neck tumor were confirmed histologically in 67 patients.
  • [MeSH-major] Head and Neck Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / mortality. Adenocarcinoma / secondary. Adenocarcinoma / surgery. Adult. Aged. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / surgery. Female. Humans. Lung Neoplasms / mortality. Lung Neoplasms / secondary. Lung Neoplasms / surgery. Lymphatic Metastasis. Male. Matched-Pair Analysis. Middle Aged. Neoplasm Staging. Prognosis. Prospective Studies. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 18648883.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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35. Dwivedi RC, Kazi R, Agrawal N, Chisholm E, St Rose S, Elmiyeh B, Rennie C, Pepper C, Clarke PM, Kerawala CJ, Rhys-Evans PH, Harrington KJ, Nutting CM: Comprehensive review of small bowel metastasis from head and neck squamous cell carcinoma. Oral Oncol; 2010 May;46(5):330-5
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  • [Title] Comprehensive review of small bowel metastasis from head and neck squamous cell carcinoma.
  • The majority of these metastatic tumours come from adenocarcinoma primaries; squamous cell carcinoma constitutes a very small proportion of all metastatic small intestinal lesions.
  • Metastasis to small bowel by head and neck squamous cell carcinoma is extremely rare and carries an unfavourable prognosis.
  • This work aims at specifying these characteristics by reviewing, compiling, analysing and reporting all published cases in the published literature on small bowel metastasis secondary to head and neck squamous cell carcinoma.
  • To the best of our knowledge, this is the first comprehensive review article on the small intestinal metastasis from head and neck squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Head and Neck Neoplasms / pathology. Intestinal Neoplasms / secondary. Intestine, Small / pathology

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  • [Copyright] Copyright (c) 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20189444.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
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36. Villaret AB, Piazza C, Peretti G, Calabrese L, Ansarin M, Chiesa F, Pellini R, Spriano G, Nicolai P: Multicentric prospective study on the prevalence of sublevel IIb metastases in head and neck cancer. Arch Otolaryngol Head Neck Surg; 2007 Sep;133(9):897-903

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multicentric prospective study on the prevalence of sublevel IIb metastases in head and neck cancer.
  • OBJECTIVE: To evaluate the prevalence of sublevel IIB lymph node (LN) metastases for head and neck primary tumors in a large cohort of patients.
  • PATIENTS: Between 2003 and 2005, 297 patients (male to female ratio, 3.5:1; mean age, 58.8 years [range, 18-89 years]) affected by head and neck cancer were treated by surgery on the primary tumor and/or the neck.
  • Primary site distribution included the following: oral cavity in 111 patients, larynx in 92, oropharynx in 32, thyroid gland in 22, skin of the lateral face or scalp in 16, hypopharynx in 11, unknown primary in 7, and parotid gland in 6.
  • INTERVENTIONS: All patients underwent unilateral or bilateral neck dissection (ND) with therapeutic or elective intent according to the primary site and clinical T (cT) and clinical N (cN) status.
  • The influence of several factors (institution in which the surgical procedure was performed, sex of the patient, site of primary, histotype, pathologic T [pT] status, cN status, lower level involved in the neck together with sublevel IIB, association with sublevel IIA metastasis, ipsilateral number of involved levels, and previous surgical treatment limited on the primary site) on the prevalence of sublevel IIB metastasis was statistically evaluated by the Pearson chi(2) test or Fisher exact test.
  • The overall prevalence of sublevel IIB metastases was 5.6% (26 neck sides).
  • Tumor histologic type in the sublevel IIB+ population was squamous cell carcinoma in 80%, papillary carcinoma in 8%, melanoma in 8%, and adenocarcinoma in 4%.
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Papillary / epidemiology. Carcinoma, Papillary / pathology. Carcinoma, Papillary / surgery. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Cross-Sectional Studies. Female. Humans. Lymph Node Excision. Male. Melanoma / epidemiology. Melanoma / pathology. Melanoma / surgery. Middle Aged. Neoplasm Staging. Prognosis. Prospective Studies. Skin Neoplasms / epidemiology. Skin Neoplasms / pathology. Skin Neoplasms / surgery

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  • (PMID = 17875856.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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37. Daniel E, McGuirt WF Sr: Neck masses secondary to heterotopic salivary gland tissue: a 25-year experience. Am J Otolaryngol; 2005 Mar-Apr;26(2):96-100
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  • [Title] Neck masses secondary to heterotopic salivary gland tissue: a 25-year experience.
  • METHODS: A retrospective chart review revealed 24 patients with asymptomatic neck masses treated between 1976 and 2001, whose pathology demonstrated heterotopic salivary tissue or neoplasms arising from heterotopic salivary tissue.
  • Malignant tumors included mucoepidermoid (3), acinic cell (2), and adenocarcinoma (1).
  • Patients were treated by a superficial parotidectomy, neck dissection, or simple excision depending on site and preoperative workup.
  • Tumorigenic changes arise from heterotopic nodal inclusions, and although infrequent, should be considered in the differential diagnosis for isolated neck/periparotid masses and parotid Warthin's tumor.
  • Suggested management, after a thorough clinical exam/needle aspiration biopsy, includes an imaging survey of the parotid gland and neck lymphatics with an appropriate resection to include a simple excision, parotidectomy, neck dissection, and/or irradiation as indicated.
  • Isolated low-grade malignant lesions/benign lesions are adequately managed by excision or parotidectomy alone.
  • High-grade malignant lesions require more extended surgery with possible irradiation.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Pleomorphic / pathology. Choristoma / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Needle. Follow-Up Studies. Humans. Lymph Nodes. Middle Aged. Neck. Retrospective Studies

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  • (PMID = 15742261.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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38. Most MD, Allori AC, Hu K, Urken ML, Persky MS, Sessions RB, Nussbaum M, Harrison LB, Frank DK, Smith ML: Feasibility of flap reconstruction in conjunction with intraoperative radiation therapy for advanced and recurrent head and neck cancer. Laryngoscope; 2008 Jan;118(1):69-74
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  • [Title] Feasibility of flap reconstruction in conjunction with intraoperative radiation therapy for advanced and recurrent head and neck cancer.
  • We review our experience with IORT in patients undergoing resection of head and neck cancer and flap reconstruction.
  • METHODS: A retrospective chart review was performed on all patients at Beth Israel Medical Center who underwent IORT for head and neck cancer between 2000 and 2007.
  • RESULTS: All patients had complex surgical wounds of the face, upper aerodigestive tract, or neck who received IORT in conjunction with pedicled or free flap closure.
  • [MeSH-major] Head and Neck Neoplasms / radiotherapy. Intraoperative Care. Neoplasm Recurrence, Local / radiotherapy. Radiology, Interventional. Reconstructive Surgical Procedures / methods. Surgical Flaps
  • [MeSH-minor] Adenocarcinoma / radiotherapy. Adenocarcinoma / surgery. Adolescent. Adult. Aged. Carcinoma, Squamous Cell / radiotherapy. Carcinoma, Squamous Cell / surgery. Feasibility Studies. Female. Follow-Up Studies. Humans. Male. Middle Aged. Postoperative Complications. Radiotherapy Dosage. Reoperation. Retrospective Studies. Surgical Wound Dehiscence / etiology. Treatment Outcome. Wound Healing / physiology

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  • (PMID = 18165718.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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39. Jeanneret-Sozzi W, Moeckli R, Valley JF, Zouhair A, Ozsahin EM, Mirimanoff RO, SASRO: The reasons for discrepancies in target volume delineation : a SASRO study on head-and-neck and prostate cancers. Strahlenther Onkol; 2006 Aug;182(8):450-7
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  • [Title] The reasons for discrepancies in target volume delineation : a SASRO study on head-and-neck and prostate cancers.
  • MATERIAL AND METHODS: 18 Swiss radiooncology centers were invited to delineate volumes for one prostate and one head-and-neck case.
  • Correlation between drawn and stated margins was fair in the prostate case and poor in the head-and-neck case.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Carcinoma, Squamous Cell / radiotherapy. Head and Neck Neoplasms / radiotherapy. Prostatic Neoplasms / radiotherapy. Radiotherapy Planning, Computer-Assisted. Tongue Neoplasms / radiotherapy
  • [MeSH-minor] Aged. CD-ROM. Humans. Lymph Nodes / pathology. Male. Neoplasm Staging. Observer Variation. Prostate / pathology. Prostate-Specific Antigen / blood. Surveys and Questionnaires. Tomography, X-Ray Computed. Tongue / pathology

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  • (PMID = 16896591.001).
  • [ISSN] 0179-7158
  • [Journal-full-title] Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
  • [ISO-abbreviation] Strahlenther Onkol
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen
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40. Hunt JL: Molecular diagnosis in head and neck: what a surgical pathologist must know. Head Neck Pathol; 2008 Jun;2(2):99-102
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  • [Title] Molecular diagnosis in head and neck: what a surgical pathologist must know.
  • In the head and neck, there are a variety of different alterations, encompassing all the different types of genetic events associated with carcinogenesis.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / genetics. Clinical Competence. Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / genetics. Pathology, Surgical / education

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  • (PMID = 20614331.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Congresses
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CDC73 protein, human; 0 / DNA, Viral; 0 / Tumor Suppressor Proteins
  • [Other-IDs] NLM/ PMC2807553
  • [Keywords] NOTNLM ; Lymphoepithelial carcinoma / Mucoepidermoid carcinoma / Nasopharyngeal carcinoma / Parathyroid carcinoma / Tumor markers
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41. Haro A, Yano T, Yoshida T, Ito K, Morodomi Y, Shoji F, Nakashima T, Maehara Y: Results of a surgical resection of pulmonary metastasis from malignant head and neck tumor. Interact Cardiovasc Thorac Surg; 2010 May;10(5):700-3
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  • [Title] Results of a surgical resection of pulmonary metastasis from malignant head and neck tumor.
  • There have been only a few reports about a surgical resection of pulmonary metastasis from malignant head and neck tumor.
  • We retrospectively reviewed 25 patients who underwent a pulmonary metastasectomy from malignant head and neck tumor at Kyushu University Hospital from 1981 through 2008.
  • To obtain a long survival, a positive surgical resection is considered to be an effective and standard treatment for pulmonary metastasis from malignant head and neck tumor.
  • It is also necessary, however, to elucidate fully the primary site and histology of such pulmonary metastasis.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Lung Neoplasms / secondary. Lung Neoplasms / surgery. Lymph Node Excision / methods. Lymph Nodes / pathology. Neoplasm Recurrence, Local / mortality
  • [MeSH-minor] Adenocarcinoma / mortality. Adenocarcinoma / secondary. Adenocarcinoma / surgery. Adolescent. Adult. Aged. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / surgery. Disease-Free Survival. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Staging. Pneumonectomy / methods. Pneumonectomy / mortality. Proportional Hazards Models. Retrospective Studies. Risk Assessment. Survival Analysis. Young Adult

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  • [Copyright] 2010 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.
  • (PMID = 20123888.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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42. Kumamoto M, Kuratomi Y, Yasumatsu R, Nakashima T, Masuda M, Inokuchi A: Expression of laminin 5 basement membrane components in invading and recurring adenoid cystic carcinoma of the head and neck. Auris Nasus Larynx; 2006 Jun;33(2):167-72
MedlinePlus Health Information. consumer health - Head and Neck Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of laminin 5 basement membrane components in invading and recurring adenoid cystic carcinoma of the head and neck.
  • OBJECTIVE: Adenoid cystic carcinoma (ACC) of the head and neck grows slowly with structural differentiation, however, this tumor nevertheless also shows a highly invasive potential and a high recurrence rate.
  • The laminin 5 BM matrices might play an important role not only in the differentiation and growth, but also in the invasion and recurrence of ACC of the head and neck.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / metabolism. Head and Neck Neoplasms / genetics. Head and Neck Neoplasms / metabolism. Laminin / genetics. Laminin / metabolism
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adult. Aged. Antibodies, Monoclonal / metabolism. Basement Membrane / metabolism. Basement Membrane / pathology. Collagen Type IV / metabolism. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 16332421.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Collagen Type IV; 0 / LAMC2 protein, human; 0 / Laminin
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43. Narayana A, Cohen GN, Zaider M, Chan K, Lee N, Wong RJ, Boyle J, Shaha A, Kraus D, Shah J, Zelefsky MJ: High-dose-rate interstitial brachytherapy in recurrent and previously irradiated head and neck cancers--preliminary results. Brachytherapy; 2007 Apr-Jun;6(2):157-63
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  • [Title] High-dose-rate interstitial brachytherapy in recurrent and previously irradiated head and neck cancers--preliminary results.
  • PURPOSE: Although high-dose-rate brachytherapy (HDRBT) offers significant advantages over low dose rate brachytherapy, there are scant data on improved local control (LC) and treatment-related complications in patients with recurrent head and neck (H&N) cancers.
  • The treatment sites were oral cavity/oropharynx (11/30), neck (10/30), face/nasal cavity (6/30), and parotid bed (3/30).
  • [MeSH-major] Brachytherapy. Head and Neck Neoplasms / radiotherapy. Hemibody Irradiation. Neoplasm Recurrence, Local
  • [MeSH-minor] Adenocarcinoma / radiotherapy. Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / radiotherapy. Carcinoma, Squamous Cell / radiotherapy. Female. Follow-Up Studies. Humans. Male. Melanoma / radiotherapy. Middle Aged. Radiation Injuries / etiology. Radiotherapy Dosage. Retrospective Studies. Sarcoma / radiotherapy. Survival Analysis. Time Factors. Treatment Outcome. Tumor Burden / radiation effects

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  • (PMID = 17434110.001).
  • [ISSN] 1538-4721
  • [Journal-full-title] Brachytherapy
  • [ISO-abbreviation] Brachytherapy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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44. Zarovnaya E, Black C: Distinguishing pseudoepitheliomatous hyperplasia from squamous cell carcinoma in mucosal biopsy specimens from the head and neck. Arch Pathol Lab Med; 2005 Aug;129(8):1032-6
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  • [Title] Distinguishing pseudoepitheliomatous hyperplasia from squamous cell carcinoma in mucosal biopsy specimens from the head and neck.
  • CONTEXT: The differentiation of pseudoepitheliomatous hyperplasia from invasive squamous cell carcinoma is a difficult and frequently encountered distinction, especially in biopsy specimens from head and neck mucosa.
  • OBJECTIVE: To distinguish pseudoepitheliomatous hyperplasia from invasive squamous cell carcinoma, utilizing a panel of antibodies to various epithelial and stromal elements (p53, matrix metalloproteinase 1, E-cadherin, and collagen IV) that has been shown to be useful in differentiating intestinal adenomas with invasive adenocarcinoma from displaced adenomatous epithelium.
  • DESIGN: Thirty-three archival specimens (16 squamous cell carcinoma [12 with invasion and 4 with microinvasion] and 17 pseudoepitheliomatous hyperplasia) from head and neck mucosal locations were immunostained and examined by the authors.
  • It appeared fragmented in benign inflamed and malignant areas and therefore was not useful.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Granular Cell Tumor / diagnosis. Head and Neck Neoplasms / diagnosis. Mouth Mucosa / pathology. Skin Diseases / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Biopsy. Cadherins / metabolism. Child. Diagnosis, Differential. Female. Humans. Hyperplasia / pathology. Immunoenzyme Techniques. Male. Matrix Metalloproteinase 1 / metabolism. Middle Aged. Tumor Suppressor Protein p53 / metabolism


45. Talmon GA, Lewis JE: Lymphocyte-depleted thymic remnants: a potential diagnostic pitfall in the evaluation of central neck dissections. Am J Clin Pathol; 2009 Nov;132(5):707-12
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  • [Title] Lymphocyte-depleted thymic remnants: a potential diagnostic pitfall in the evaluation of central neck dissections.
  • The head and neck region is a frequent site for potentially confusing incidental benign findings not related to the primary pathologic process and having no impact on patient prognosis.
  • We report 3 cases of lymphocyte-poor thymic remnants identified in central cervical (level VI) lymph node dissections for unrelated benign and malignant pathology.
  • [MeSH-major] Incidental Findings. Neck Dissection. Thymus Gland / pathology
  • [MeSH-minor] Adenocarcinoma, Papillary / surgery. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Head and Neck Neoplasms / pathology. Humans. Hyperparathyroidism / surgery. Immunohistochemistry. Lymphocytes / pathology. Male. Parathyroidectomy. Thyroid Neoplasms / surgery

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  • (PMID = 19846811.001).
  • [ISSN] 1943-7722
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Paleri V, Robinson M, Bradley P: Polymorphous low-grade adenocarcinoma of the head and neck. Curr Opin Otolaryngol Head Neck Surg; 2008 Apr;16(2):163-9
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  • [Title] Polymorphous low-grade adenocarcinoma of the head and neck.
  • PURPOSE OF REVIEW: Polymorphous low-grade adenocarcinoma is an entity described in 1984.
  • The natural history of polymorphous low-grade adenocarcinoma is distinct from other malignant salivary tumours.
  • RECENT FINDINGS: Polymorphous low-grade adenocarcinoma is a slow-growing tumour that is locally invasive.
  • Diagnosis is established after a biopsy because cytological studies are not helpful.
  • The role of radiation therapy is not clear in the management of polymorphous low-grade adenocarcinoma.
  • SUMMARY: Polymorphous low-grade adenocarcinoma is primarily a pathologic diagnosis.
  • [MeSH-major] Adenocarcinoma / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 18327037.001).
  • [ISSN] 1531-6998
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 60
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47. Jingu K, Hasegawa A, Mizo JE, Bessho H, Morikawa T, Tsuji H, Tsujii H, Kamada T: Carbon ion radiotherapy for basal cell adenocarcinoma of the head and neck: preliminary report of six cases and review of the literature. Radiat Oncol; 2010;5:89
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  • [Title] Carbon ion radiotherapy for basal cell adenocarcinoma of the head and neck: preliminary report of six cases and review of the literature.
  • BACKGROUND: Basal cell adenocarcinoma accounts for approximately 1.6% of all salivary gland neoplasms.
  • METHODS: Case records of 6 patients with diagnosis of basal cell adenocarcinoma of the head and neck, who were treated by carbon ion radiotherapy with 64.0 GyE/16 fractions in our institution, were retrospectively reviewed.
  • CONCLUSIONS: Carbon ion radiotherapy should be considered as an appropriate curative approach for treatment of basal cell adenocarcinoma in certain cases, particularly in cases of unresectable disease and postoperative gross residual or recurrent disease.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Carbon / therapeutic use. Head and Neck Neoplasms / radiotherapy. Heavy Ions / therapeutic use

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  • (PMID = 20920325.001).
  • [ISSN] 1748-717X
  • [Journal-full-title] Radiation oncology (London, England)
  • [ISO-abbreviation] Radiat Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 7440-44-0 / Carbon
  • [Other-IDs] NLM/ PMC2958970
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48. Xia LP, Zhang B, Liu MZ, Hu PL, Chen XX, Guo GF, Qiu HJ, Rong YM, Qian SY, Zhou FF, Huang YY, Wang TL: [Short-term efficacy of cetuximab combined with radiotherapy or chemotherapy on head and neck cancer: a report of 11 cases]. Ai Zheng; 2009 Sep;28(9):977-82
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  • [Title] [Short-term efficacy of cetuximab combined with radiotherapy or chemotherapy on head and neck cancer: a report of 11 cases].
  • BACKGROUND AND OBJECTIVE: Cetuximab combined with radiotherapy or chemotherapy has been used to treat head and neck cancer in recent years, but few reports are available in China now.
  • This study was to summarize our experiences in treating patients with head and neck cancer cetuximab.
  • METHODS: From October 1st, 2005 to September 30th, 2008, six with patients head and neck cancer were treated using cetuximab combined with radiotherapy and five were treated using cetuximab combined with chemotherapy in Sun Yat-sen University Cancer Center.
  • CONCLUSION: Cetuximab combined with either radiotherapy or chemotherapy are good options for suitable patients with head and neck cancer.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Head and Neck Neoplasms / drug therapy. Hypopharyngeal Neoplasms / drug therapy
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / radiotherapy. Adult. Aged. Aged, 80 and over. Antibodies, Monoclonal, Humanized. Antineoplastic Agents / therapeutic use. Cetuximab. Combined Modality Therapy. Disease Progression. Exanthema / chemically induced. Female. Follow-Up Studies. Humans. Male. Middle Aged. Remission Induction. Retrospective Studies

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  • (PMID = 19728918.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; PQX0D8J21J / Cetuximab
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49. Sato T, Kawabata Y, Kobayashi Y, Suenaga S, Indo H, Kawano K, Iwashita Y, Morita Y, Majima HJ: Scintigraphy for interpretation of malignant tumours of the head and neck: comparison of technetium-99m-hexakis-2-methoxyisobutylisonitrile (Tc-MIBI) and thallium-201-chloride (Tl-201). Dentomaxillofac Radiol; 2005 Sep;34(5):268-73
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  • [Title] Scintigraphy for interpretation of malignant tumours of the head and neck: comparison of technetium-99m-hexakis-2-methoxyisobutylisonitrile (Tc-MIBI) and thallium-201-chloride (Tl-201).
  • METHODS: Dynamic and static scintigraphic imaging with 99Tc(m)-MIBI and Tl-201 were performed on patients with a variety of malignant and benign tumours.
  • In addition to these factors, the grade of tissue differentiation and tumour size were evaluated to clarify the difference between 99Tc(m)-MIBI and Tl-201 for the diagnosis of malignant tumours of the head and neck.
  • CONCLUSIONS: There was no major difference between 99Tc(m)-MIBI and Tl-201scintigraphy with respect to accuracy of diagnosis of malignant tumours of the head and neck.
  • [MeSH-major] Carcinoma, Squamous Cell / radionuclide imaging. Head and Neck Neoplasms / radionuclide imaging. Radiopharmaceuticals. Technetium Tc 99m Sestamibi. Thallium Radioisotopes
  • [MeSH-minor] Adenocarcinoma / radionuclide imaging. Adenolymphoma / radionuclide imaging. Adenoma, Pleomorphic / radionuclide imaging. Adult. Aged. Aged, 80 and over. Cell Differentiation. Female. Humans. Male. Middle Aged. Regional Blood Flow / physiology. Retrospective Studies. Thallium. Time Factors

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  • (PMID = 16120875.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0 / Thallium Radioisotopes; 7791-12-0 / thallium chloride; 971Z4W1S09 / Technetium Tc 99m Sestamibi; AD84R52XLF / Thallium
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50. Hasebe M, Yoshikawa K, Ohashi S, Toubaru S, Kawaguchi K, Sato J, Mizoe J, Tsujii H: A study on the prognostic evaluation of carbon ion radiotherapy for head and neck adenocarcinoma with C-11 methionine PET. Mol Imaging Biol; 2010 Oct;12(5):554-62
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  • [Title] A study on the prognostic evaluation of carbon ion radiotherapy for head and neck adenocarcinoma with C-11 methionine PET.
  • PURPOSE: Carbon ion radiotherapy (CIRT) has been developed, and a phase I/II CIRT trial has been conducted in patients with adenocarcinoma in the head and neck region.
  • We evaluated whether the L-methyl [11C]-methionine (MET) uptake could be an early predictor for local recurrence, metastasis, and the prognosis in patients with adenocarcinoma in the head and neck region.
  • CONCLUSIONS: The determination of treatment effectiveness using TNR in CIRT for head and neck adenocarcinoma is an independent factor for predicting local recurrence, the incidence of metastasis, and the prognosis.
  • MET-PET is therefore considered to be useful for determining the treatment effectiveness in patients with head and neck adenocarcinoma undergoing CIRT.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Head and Neck Neoplasms / radiotherapy. Methionine. Positron-Emission Tomography

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  • (PMID = 20369300.001).
  • [ISSN] 1860-2002
  • [Journal-full-title] Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging
  • [ISO-abbreviation] Mol Imaging Biol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carbon Radioisotopes; AE28F7PNPL / Methionine
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51. Koh YW, Park JH, Kim JW, Lee SW, Choi EC: Endoscopic hemithyroidectomy with prophylactic ipsilateral central neck dissection via an unilateral axillo-breast approach without gas insufflation for unilateral micropapillary thyroid carcinoma: preliminary report. Surg Endosc; 2010 Jan;24(1):188-97
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  • [Title] Endoscopic hemithyroidectomy with prophylactic ipsilateral central neck dissection via an unilateral axillo-breast approach without gas insufflation for unilateral micropapillary thyroid carcinoma: preliminary report.
  • However, few specific data exist on endoscopic thyroidectomy with central neck dissection (CND) for micropapillary thyroid carcinoma.
  • [MeSH-major] Adenocarcinoma, Papillary / surgery. Endoscopy / methods. Lymph Node Excision / methods. Thyroid Neoplasms / surgery. Thyroidectomy / methods

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  • (PMID = 19688395.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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52. Doobaree IU, Landis SH, Linklater KM, El-Hariry I, Moller H, Tyczynski J: Head and neck cancer in South East England between 1995-1999 and 2000-2004: An estimation of incidence and distribution by site, stage and histological type. Oral Oncol; 2009 Sep;45(9):809-14
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  • [Title] Head and neck cancer in South East England between 1995-1999 and 2000-2004: An estimation of incidence and distribution by site, stage and histological type.
  • Population-based data on head and neck cancer (HNC) stage and histological type are poorly described for England; these data are essential for clinical management and research.
  • Males were two to six times as likely as females to be diagnosed with HNC and there was a trend toward younger age at diagnosis over time.
  • [MeSH-major] Head and Neck Neoplasms / epidemiology
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Adolescent. Adult. Age Distribution. Aged. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / pathology. Child. Child, Preschool. England / epidemiology. Female. Humans. Incidence. Infant. Infant, Newborn. Male. Middle Aged. Registries. Sex Distribution. Young Adult

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  • (PMID = 19251472.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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53. Tatomirovic Z, Skuletic V, Bokun R, Trimcev J, Radic O, Cerovic S, Strbac M, Zolotarevski L, Tukic Lj, Stamatovic D, Tarabar O: Fine needle aspiration cytology in the diagnosis of head and neck masses: accuracy and diagnostic problems. J BUON; 2009 Oct-Dec;14(4):653-9
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  • [Title] Fine needle aspiration cytology in the diagnosis of head and neck masses: accuracy and diagnostic problems.
  • PURPOSE: Fine needle aspiration (FNA) cytology is an established technique associated with minimal complications compared with more invasive techniques such as wide core needle biopsy or open biopsy, and as such, very suitable for obtaining material in the delicate region of head and neck (H&N).
  • Sixty-four (12.6%) FNA specimens were inadequate for diagnosis.
  • The overall accuracy rate of FNA cytology, whether malignant or benign, was 91.89%, while the diagnostic accuracy for the exact type of tumor was 87.16%.
  • The sensitivity and specificity of FNA cytology in determining a malignant diagnosis were 91.5% and 92.85%, respectively.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Lymphoma / diagnosis. Pseudolymphoma / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Biopsy, Fine-Needle. Biopsy, Needle. Carcinoma, Small Cell / diagnosis. Carcinoma, Small Cell / secondary. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / secondary. Cytological Techniques. Diagnosis, Differential. Diagnostic Errors. Humans. Neoplasm Staging. Prognosis. Sensitivity and Specificity

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  • (PMID = 20148458.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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54. Werbrouck J, De Ruyck K, Duprez F, Veldeman L, Claes K, Van Eijkeren M, Boterberg T, Willems P, Vral A, De Neve W, Thierens H: Acute normal tissue reactions in head-and-neck cancer patients treated with IMRT: influence of dose and association with genetic polymorphisms in DNA DSB repair genes. Int J Radiat Oncol Biol Phys; 2009 Mar 15;73(4):1187-95
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  • [Title] Acute normal tissue reactions in head-and-neck cancer patients treated with IMRT: influence of dose and association with genetic polymorphisms in DNA DSB repair genes.
  • MATERIALS AND METHODS: The study population consisted of 88 intensity-modulated radiation therapy (IMRT)-treated head-and-neck cancer patients.
  • [MeSH-major] DNA Repair / genetics. Deglutition Disorders / genetics. Head and Neck Neoplasms / radiotherapy. Polymorphism, Genetic / genetics. Radiotherapy, Intensity-Modulated / adverse effects
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / radiotherapy. Adult. Aged. Aged, 80 and over. Antigens, Nuclear / genetics. Arabidopsis Proteins / genetics. Carcinoma, Squamous Cell / genetics. Carcinoma, Squamous Cell / radiotherapy. DNA Ligases / genetics. DNA-Binding Proteins / genetics. Female. Humans. Male. Middle Aged. Mouth / radiation effects. Mouth Mucosa / radiation effects. Pharyngeal Muscles / radiation effects. Rad51 Recombinase / genetics. Radiodermatitis / genetics. Radiotherapy Dosage. Regression Analysis

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  • (PMID = 19251090.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Nuclear; 0 / Arabidopsis Proteins; 0 / DNA-Binding Proteins; 0 / Ku autoantigen; 0 / X-ray repair cross complementing protein 3; EC 2.7.7.- / ATRAD51 protein, Arabidopsis; EC 2.7.7.- / Rad51 Recombinase; EC 6.5.1.- / DNA Ligases; EC 6.5.1.1 / DNA ligase (ATP)
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55. Brønden LB, Eriksen T, Kristensen AT: Oral malignant melanomas and other head and neck neoplasms in Danish dogs--data from the Danish Veterinary Cancer Registry. Acta Vet Scand; 2009;51:54
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  • [Title] Oral malignant melanomas and other head and neck neoplasms in Danish dogs--data from the Danish Veterinary Cancer Registry.
  • BACKGROUND: Head and neck cancers (HNC) are relatively common and often very serious diseases in both dogs and humans.
  • Neoplasms originating in the head and neck region are a heterogeneous group.
  • In humans oral malignant melanoma (OMM) is extremely rare, but represents a particular challenge since it is highly aggressive as is the canine counterpart, which thus may be of interest as a spontaneous animal model.
  • Also the proportions of benign and malignant neoplasms of different locations in dogs were compared using Fisher's exact test.
  • RESULTS: A total of 1768 cases of neoplasias (679 malignant, 826 benign, 263 unknown) were submitted.
  • Of these, 64 (50%) were malignant and 44 (34%) benign.
  • The most common types of malignant neoplasia were SCC (18; 28% of malignant), OMM (13; 20% of malignant), soft tissue sarcoma (11; 17% of malignant) and adenocarcinoma (5; 11% of malignant).
  • CONCLUSIONS: In the current study, the proportion of neoplasia in the head and neck region in dogs in Denmark was similar to other canine studies and significantly more common than in humans with a large proportion of malignancies.
  • [MeSH-major] Dog Diseases / epidemiology. Head and Neck Neoplasms / veterinary. Melanoma / veterinary. Mouth Neoplasms / veterinary. Registries

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  • (PMID = 20021647.001).
  • [ISSN] 1751-0147
  • [Journal-full-title] Acta veterinaria Scandinavica
  • [ISO-abbreviation] Acta Vet. Scand.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2803174
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56. Syed IM, Howard DJ: Should we treat lung metastases from adenoid cystic carcinoma of the head and neck in asymptomatic patients? Ear Nose Throat J; 2009 Jun;88(6):969-73
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  • [Title] Should we treat lung metastases from adenoid cystic carcinoma of the head and neck in asymptomatic patients?
  • Adenoid cystic carcinoma is a rare malignant tumor that is well known for its deceptively encouraging 5-year survival rate and its dismal survival rate at longer intervals.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Head and Neck Neoplasms / pathology. Lung Neoplasms / secondary
  • [MeSH-minor] Adenocarcinoma / secondary. Adenocarcinoma / surgery. Adult. Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / surgery. Female. Humans. Prognosis. Thoracotomy. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19517404.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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57. Lee P, de Bree R, Brokx HA, Leemans CR, Postmus PE, Sutedja TG: Primary lung cancer after treatment of head and neck cancer without lymph node metastasis: is there a role for autofluorescence bronchoscopy? Lung Cancer; 2008 Dec;62(3):309-15
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  • [Title] Primary lung cancer after treatment of head and neck cancer without lymph node metastasis: is there a role for autofluorescence bronchoscopy?
  • BACKGROUND: Head and neck cancer (HNC) is the 5th most common cancer worldwide.
  • [MeSH-major] Bronchoscopy. Carcinoma, Non-Small-Cell Lung / diagnosis. Head and Neck Neoplasms / pathology. Neoplasms, Second Primary / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / drug therapy. Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Adenocarcinoma, Bronchiolo-Alveolar / drug therapy. Adult. Aged. Carcinoma, Large Cell / diagnosis. Carcinoma, Large Cell / drug therapy. Female. Fluorescence. Humans. Lung Neoplasms / diagnosis. Lung Neoplasms / drug therapy. Lymphatic Metastasis. Male. Middle Aged. Prognosis. Prospective Studies. Small Cell Lung Carcinoma / diagnosis. Small Cell Lung Carcinoma / drug therapy. Smoking. Survival Rate. Treatment Outcome

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  • [CommentIn] Lung Cancer. 2009 Aug;65(2):255 [19410330.001]
  • (PMID = 18486989.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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58. Brouwer J, Senft A, de Bree R, Comans EF, Golding RP, Castelijns JA, Hoekstra OS, Leemans CR: Screening for distant metastases in patients with head and neck cancer: is there a role for (18)FDG-PET? Oral Oncol; 2006 Mar;42(3):275-80
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  • [Title] Screening for distant metastases in patients with head and neck cancer: is there a role for (18)FDG-PET?
  • In addition, (18)FDG-PET detected second primary tumours in two patients (hepatocellular carcinoma and abdominal adenocarcinoma).
  • [MeSH-major] Carcinoma, Squamous Cell / radionuclide imaging. Carcinoma, Squamous Cell / secondary. Fluorodeoxyglucose F18. Head and Neck Neoplasms / radionuclide imaging. Positron-Emission Tomography / methods. Radiopharmaceuticals

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  • (PMID = 16266820.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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59. Savage JR, Saleh HA, Clarke PM: A new combined approach to the nasopharynx in head and neck plastic surgery: technique and application. J Laryngol Otol; 2006 Jul;120(7):591-3

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  • [Title] A new combined approach to the nasopharynx in head and neck plastic surgery: technique and application.
  • [MeSH-major] Adenocarcinoma / surgery. Nasopharyngeal Neoplasms / surgery. Nasopharynx / surgery

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  • (PMID = 16834806.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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60. Barber B, Côté D, Seikaly H: Clearing up clear cell tumours of the head and neck: differentiation of hyalinizing and odontogenic varieties. J Otolaryngol Head Neck Surg; 2010 Oct;39(5):E56-60
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  • [Title] Clearing up clear cell tumours of the head and neck: differentiation of hyalinizing and odontogenic varieties.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Head and Neck Neoplasms / diagnosis. Odontogenic Tumors / diagnosis
  • [MeSH-minor] Aged. Biopsy. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 20828504.001).
  • [ISSN] 1916-0216
  • [Journal-full-title] Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
  • [ISO-abbreviation] J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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61. Marsh DJ, Chana JS: Use of the anterolateral thigh flap and combined vascularised fascia lata sling to provide static support following facial nerve resection in head and neck cancer reconstruction. J Plast Reconstr Aesthet Surg; 2008 Sep;61(9):1116-9
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  • [Title] Use of the anterolateral thigh flap and combined vascularised fascia lata sling to provide static support following facial nerve resection in head and neck cancer reconstruction.
  • [MeSH-minor] Adenocarcinoma / surgery. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / surgery. Facial Paralysis / prevention & control. Female. Head and Neck Neoplasms / surgery. Humans. Male. Melanoma / surgery. Middle Aged. Thigh

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  • (PMID = 18639506.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
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62. Grunstein E, Kacker A: Salivary gland cystadenocarcinoma of the mobile tongue, low-grade papillary adenocarcinoma variant: a case report. Ear Nose Throat J; 2006 Dec;85(12):829-30
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  • [Title] Salivary gland cystadenocarcinoma of the mobile tongue, low-grade papillary adenocarcinoma variant: a case report.
  • Cystadenocarcinoma is a rare malignant neoplasm of the salivary gland.
  • Treatment involves local excision; neck dissection and postoperative radiation therapy are used for clinically positive neck metastases.
  • [MeSH-major] Cystadenocarcinoma, Papillary / diagnosis. Salivary Gland Neoplasms / diagnosis

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  • (PMID = 17240709.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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63. Koo BS, Yoon YH, Kim JM, Choi EC, Lim YC: Predictive factors of level IIb lymph node metastasis in patients with papillary thyroid carcinoma. Ann Surg Oncol; 2009 May;16(5):1344-7
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  • BACKGROUND: The extent of neck dissection (ND) appropriate for necks yielding clinical evidence of metastases of papillary thyroid carcinoma (PTC) is controversial.
  • In the present study, we examined the frequency, pattern, and predictive factors of level IIb LN metastases in PTC patients with clinically positive lateral neck nodes.
  • METHODS: We reviewed the medical records of 76 PTC patients who underwent therapeutic lateral ND for the treatment of clinically positive lateral neck nodes between March 2005 and July 2008.
  • ND specimens were separately obtained for analyzing LN involvement with respect to neck level.
  • By univariate analysis, the rate of level IIb LN metastasis was significantly higher in patients with positive level IIa LNs and positive LNs in all lateral neck levels (levels IIa + III + IV) (P < .05).
  • Multivariate analysis showed that positive LN involvement in all lateral neck levels (IIa + III + IV) was an independent predictive factor of level IIb LN metastasis (P = .044, odds ratio = 9.692).
  • CONCLUSIONS: Level IIb LN dissection may be omitted in the treatment of positive neck nodes in PTC patients if multilevel involvement including level IIa involvement is absent.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Lymph Nodes / pathology. Neck Dissection. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Predictive Value of Tests. Prognosis. Retrospective Studies. Thyroidectomy. Young Adult

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  • (PMID = 19224280.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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64. Tincani AJ, Altemani A, Martins AS, Barreto G, Valério JB, Del Negro A, Araújo PP: Polymorphous low-grade adenocarcinoma at the base of the tongue: an unusual location. Ear Nose Throat J; 2005 Dec;84(12):794-5, 799
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  • [Title] Polymorphous low-grade adenocarcinoma at the base of the tongue: an unusual location.
  • Polymorphous low-grade adenocarcinoma (PLGA) is a malignant neoplasm of low aggressiveness that occurs almost exclusively in the minor salivary glands, primarily those in the palate.
  • We report a case of PLGA that arose in the base of the tongue and subsequently metastasized to the neck.
  • The neck metastasis was treated with radical neck dissection and radiotherapy.
  • [MeSH-major] Adenocarcinoma / pathology. Tongue Neoplasms / pathology

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  • (PMID = 16408562.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Murray K, Patel R, Payne-Blackmon SP: Primary cutaneous mucinous adenocarcinoma of the face: a case report in a 63 year-old. Laryngoscope; 2010;120 Suppl 4:S133

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  • [Title] Primary cutaneous mucinous adenocarcinoma of the face: a case report in a 63 year-old.
  • Primary cutaneous mucinous adenocarcinoma is a rare sweat gland malignancy that most commonly occurs in the head and neck region.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Facial Neoplasms / diagnosis

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  • (PMID = 21225731.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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66. Spriano G, Ruscito P, Pellini R, Appetecchia M, Roselli R: Pattern of regional metastases and prognostic factors in differentiated thyroid carcinoma. Acta Otorhinolaryngol Ital; 2009 Dec;29(6):312-6
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  • Neck dissection, margin infiltration and extra-capsular spread were significant prognostic factors.
  • The Authors present a retrospective study of 77 patients with primary differentiated thyroid carcinoma, submitted to thyroidectomy and neck dissection aimed at analysing distribution of nodal metastases according to Robbins' levels classification and defining their prognostic value.
  • All N1b cases, retrospectively reviewed (n. 77), presented clinical and histological evidence of neck nodes metastases from differentiated thyroid carcinoma; histological reports indicated tumour localisation and topographical distribution of metastases; papillary carcinoma was the most common type (72 cases), followed by follicular carcinoma (5 cases).
  • Overall 52 cases were submitted to monolateral neck dissection, 25 to bilateral neck dissection.
  • Treatment of the lateral neck was postero-lateral neck dissection (n. 53), selective lateral neck dissection (n. 20), modified radical and radical (n. 29).
  • Statistically significant prognostic factors for distant metastases and recurrence on the neck were follicular carcinoma (p < 0.01) and extra-capsular spread (p < 0.001).
  • In the Authors' experience, histological grade of differentiation, wide tumour excision and neck dissection, in cases of N1b well-differentiated thyroid carcinoma, without residual disease (R1, R2), in the central and lateral neck, are determinant prognostic factors.
  • [MeSH-minor] Adenocarcinoma, Follicular. Adolescent. Adult. Aged. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Prognosis. Retrospective Studies. Young Adult

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  • (PMID = 20463835.001).
  • [ISSN] 1827-675X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2868202
  • [Keywords] NOTNLM ; Extra-capsular spread / Nodal metastases / Thyroid carcinoma
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67. Gong W, Wang E, Da J, Tan Z, Chen W: [Misdiagnosis and mistherapy of ectopic thyroid gland]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2006 May;20(9):402-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To explore the clinic characteristic, diagnosis and treatment of ectopic thyroid gland (ETG) and avoid the misdiagnosis and mistherapy of ETG.
  • The clinical features, diagnosis and management of ETG were discussed.
  • RESULT: All of patients had a normal thyroid gland in the neck and underwent a surgical resection of neck mass.
  • Postoperative pathologic examination revealed the neck masses originated from accessory thyroid gland, of them, 1 gland enlargement, 1 adenoma and 2 adenocarcinoma.
  • CONCLUSION: The well understanding of ETG and the detailed examination before surgical treatment of neck mass, including ultrasonography, CT or MRI, radioactive isotope scanning and fine needle aspiration biopsy, are keys to adequate diagnosis and management of ETG.
  • [MeSH-major] Choristoma / diagnosis. Diagnostic Errors. Thyroglossal Cyst / diagnosis. Thyroid Gland / pathology

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  • (PMID = 16836074.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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68. Li ZD, Dong HL, Li SC: [Operation for well-differentiated invading thyroid carcinoma]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2006 Jun;41(6):403-7
MedlinePlus Health Information. consumer health - Thyroid Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • One hundred and twenty nine cases simultaneous neck dissection (5 cases bilateral neck dissection), in them, 75 neck radical neck dissection, 59 neck modified dissection.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Thyroid Neoplasms / pathology. Thyroid Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Retrospective Studies. Young Adult

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  • (PMID = 16927792.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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69. Takemura T, Ogata N, Yumoto E: [Clinical analysis of cervical metastatis from an unknown primary carcinoma]. Nihon Jibiinkoka Gakkai Kaiho; 2005 Oct;108(10):996-1003
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • With respect to the histopathological types, 16 cases had squamous cell carcinoma, 2 cases had adenocarcinoma and 1 case had ductal carcinoma.
  • Seventeen patients were treated with neck dissection.
  • Eleven patients with neck dissection underwent radiotherapy.
  • The 3-year survival rate of the 17 cases whose metastatic leisions were treated with radical neck dissection was 66%.
  • Radiotherapy with radical neck dissection was thought more effective than radical neck dissection for local and neck control.
  • [MeSH-major] Adenocarcinoma / secondary. Carcinoma, Ductal / secondary. Carcinoma, Squamous Cell / secondary. Head and Neck Neoplasms / secondary. Neoplasms, Unknown Primary

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  • (PMID = 16285615.001).
  • [ISSN] 0030-6622
  • [Journal-full-title] Nihon Jibiinkoka Gakkai kaiho
  • [ISO-abbreviation] Nippon Jibiinkoka Gakkai Kaiho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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70. Bień S, Kamiński B, Okła S, Kopczyński J: [Metastasis of rectal adenocarcinoma to the skull base and paranasal sinuses, with unusual clinical symptoms]. Otolaryngol Pol; 2005;59(4):627-30

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Metastasis of rectal adenocarcinoma to the skull base and paranasal sinuses, with unusual clinical symptoms].
  • INTRODUCTION: The isolated distant metastasis of digestive tract adenocarcinoma, to the head and neck region is very rare.
  • MATERIAL AND METHODS: The diagnosis in 71 years female patient was based on CT, endoscopic examination and biopsy, and pathologic examination, with immunohistochemical differentiation between primary intestinal type adenocarcinoma of paranasal sinuses, and metastasis of adenocarcinoma from digestive tract.
  • RESULTS: The immunohistochemical staining (CEA +, CK20 +, CK7 -, ChrA -, NSE -) proved the diagnosis.
  • The patient died 2 months after diagnosis was established.
  • CONCLUSIONS: The importance of differential diagnosis between the primary intestinal type adenocarcinoma in the upper respiratory tract and metastases of adenocarcinoma from digestive tract to head and neck region is crucial, due to entirely different type of treatment planning in both situations.
  • [MeSH-major] Adenocarcinoma / secondary. Paranasal Sinus Neoplasms / secondary. Rectal Neoplasms / pathology. Skull Base Neoplasms / secondary
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Immunohistochemistry

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  • (PMID = 16273875.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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71. Iguchi H, Uyama T, Kanazawa A, Amatsu H, Yamane H, Kusuki M, Nakamura A: [A successful case of advanced nasal adenocarcinoma treated with tumor dormancy therapy with S -1 alone]. Gan To Kagaku Ryoho; 2008 Dec;35(13):2389-91
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  • [Title] [A successful case of advanced nasal adenocarcinoma treated with tumor dormancy therapy with S -1 alone].
  • We report a 65-year-old female case of low-grade non-intestinal type adenocarcinoma of the nasal cavity with bilateral metastases to the cervical lymph nodes(T3N2cM0: Stage IV A).
  • Although the effectiveness of S-1 for adenocarcinoma of the head and neck has not been fully demonstrated, S-1 might be useful in patients with advanced head and neck adenocarcinoma for the purpose of TDT.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Nose Neoplasms / drug therapy. Oxonic Acid / therapeutic use. Tegafur / therapeutic use

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  • (PMID = 19098408.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid
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72. Urken ML: Prognosis and management of invasive well-differentiated thyroid cancer. Otolaryngol Clin North Am; 2010 Apr;43(2):301-28, viii
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Specific guidelines are provided for the management of the various structures in the neck that are at risk for involvement by disease extension outside the gland or extracapsular extension outside a lymph node with involvement by metastatic disease.
  • This article reviews the prognosis, diagnosis, management, and implications of invasive thyroid cancer affecting the various structures of the central and lateral compartments of the neck.
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Adenocarcinoma, Follicular / surgery. Carcinoma, Papillary / pathology. Carcinoma, Papillary / surgery. Thyroid Neoplasms / pathology. Thyroid Neoplasms / surgery
  • [MeSH-minor] Disease Progression. Esophagus / pathology. Esophagus / surgery. Humans. Jugular Veins / pathology. Jugular Veins / surgery. Larynx / pathology. Larynx / surgery. Lymph Node Excision / methods. Lymphatic Metastasis / pathology. Neoplasm Invasiveness. Neoplasm Staging. Prognosis. Recurrent Laryngeal Nerve / pathology. Recurrent Laryngeal Nerve / surgery. Suture Techniques. Thyroid Gland / pathology. Trachea / pathology. Trachea / surgery

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20510716.001).
  • [ISSN] 1557-8259
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 43
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73. Das S, Kirsch CF: Imaging of lumps and bumps in the nose: a review of sinonasal tumours. Cancer Imaging; 2005;5:167-77

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Sinonasal disease is one of the most common clinical head and neck pathologies.
  • The majority of sinonasal pathology is inflammatory with neoplasms comprising approximately 3% of all head and neck tumours.
  • Although sinus tumours are rare, they portend a poor prognosis, often due to advanced disease at diagnosis.
  • Malignant neoplasms reviewed include squamous cell carcinoma, the minor salivary gland tumour, adenoid cystic carcinoma, adenocarcinoma, melanoma, lymphoma, and olfactory neuroblastoma (esthesioneuroblastoma).
  • [MeSH-major] Paranasal Sinus Neoplasms / diagnosis

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  • [Copyright] International Cancer Imaging Society.
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  • (PMID = 16361146.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 73
  • [Other-IDs] NLM/ PMC1665243
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74. Pai SI, Tufano RP: Reoperation for recurrent/persistent well-differentiated thyroid cancer. Otolaryngol Clin North Am; 2010 Apr;43(2):353-63, ix
MedlinePlus Health Information. consumer health - Thyroid Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Reoperative surgery in the neck for recurrent/persistent well-differentiated thyroid cancer is associated with increased morbidity compared with primary surgery.
  • This algorithm should include a systematic review of prior operative and pathology notes, imaging studies appropriate for localization of disease, an understanding of reoperative central and lateral neck anatomy, along with an appreciation for disease behavior.
  • [MeSH-major] Adenocarcinoma, Follicular / surgery. Carcinoma, Medullary / surgery. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm, Residual / surgery. Thyroid Neoplasms / pathology. Thyroid Neoplasms / surgery
  • [MeSH-minor] Algorithms. Diagnostic Imaging. Humans. Lymph Node Excision. Neoplasm Invasiveness. Neoplasm Staging. Parathyroid Glands / blood supply. Parathyroid Glands / pathology. Parathyroid Glands / surgery. Prognosis. Recurrent Laryngeal Nerve Injuries. Reoperation. Risk Factors. Thyroidectomy

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20510718.001).
  • [ISSN] 1557-8259
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 46
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75. Kupferman ME, Weinstock YE, Santillan AA, Mishra A, Roberts D, Clayman GL, Weber RS: Predictors of level V metastasis in well-differentiated thyroid cancer. Head Neck; 2008 Nov;30(11):1469-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • However, there is no consensus regarding the appropriate levels of the neck that need to be dissected.
  • Treatment options that have been advocated include the modified radical neck dissection, limited neck dissections, and selective nodal excisions.
  • METHODS: We retrospectively analyzed 70 patients who underwent thyroidectomy and neck dissection for well-differentiated thyroid cancer at M. D.
  • RESULTS: In our series, 53% of neck specimens harbored metastatic thyroid carcinoma at level V.
  • Additionally, 13 level V contralateral neck dissections were performed, and 57% were found positive for metastases.
  • We believe that routine dissection of the level V lymph nodes should be performed in the setting of a comprehensive neck dissection for patients with lateral neck metastasis from well-differentiated thyroid cancer.
  • [MeSH-major] Adenocarcinoma, Follicular / secondary. Adenocarcinoma, Papillary / secondary. Neck Dissection. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Risk Assessment. Sensitivity and Specificity. Severity of Illness Index. Thyroidectomy

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  • [Copyright] (c) 2008 Wiley Periodicals, Inc. Head Neck, 2008.
  • (PMID = 18704973.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Cibull TL, Thomas AB, Badve S, Billings SD: Sebaceous carcinoma of the nipple. J Cutan Pathol; 2008 Jun;35(6):608-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Sebaceous carcinoma (SC) is an uncommon neoplasm that usually presents as an ocular or extraocular cutaneous lesion of the head and neck.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Breast Neoplasms / pathology. Nipples / pathology

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  • (PMID = 18466364.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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77. Xu Y, Wang J: [Analysis of lymph node metastasis factors in papillary thyroid microcarcinoma]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2007 Aug;21(15):679-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To analyze the factors of lymph node metastasis in papillary thyroid microcarcinoma and to evaluate the significance of the selective neck dissection.
  • Sixty patients were received a selective neck dissection (Group 1), while twenty-two were not (Group 2).
  • It is more significant to perform selective neck dissection in tumors > or = 0.7 cm.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Lymphatic Metastasis / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neck Dissection. Retrospective Studies. Young Adult

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  • (PMID = 17969517.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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78. Nunnelee JD: Superior vena cava syndrome. J Vasc Nurs; 2007 Mar;25(1):2-5; quiz 6
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  • Adenocarcinoma of the lung is the most common cause.
  • Symptoms may include a feeling of fullness in the head, dyspnea, and cough.
  • Clinical findings may include facial and neck swelling; dilated venous channels over the trunk, upper extremities, and neck; facial flushing; cyanosis; respiratory stridor and distress; and neurologic signs.
  • Primary symptoms are in the neck and head.
  • [MeSH-minor] Adenocarcinoma / complications. Aneurysm, Infected / complications. Angioplasty. Causality. Chest Pain / etiology. Cough / etiology. Cyanosis / etiology. Deglutition Disorders / etiology. Diagnosis, Differential. Dyspnea / etiology. Humans. Lung Neoplasms / complications. Nurse's Role. Patient Education as Topic. Phlebography. Physical Examination. Respiratory Sounds / etiology. Stents. Syphilis / complications. Thrombosis / complications. Tuberculosis, Cardiovascular / complications

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  • (PMID = 17324762.001).
  • [ISSN] 1062-0303
  • [Journal-full-title] Journal of vascular nursing : official publication of the Society for Peripheral Vascular Nursing
  • [ISO-abbreviation] J Vasc Nurs
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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79. Boscolo-Rizzo P, Gava A, Da Mosto MC: Carcinoma metastatic to cervical lymph nodes from an occult primary tumor: the outcome after combined-modality therapy. Ann Surg Oncol; 2007 May;14(5):1575-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The aim of this retrospective analysis was to analyze the results of treatment of patients with cervical node metastases from carcinoma of occult primary with a policy including neck dissection and postoperative comprehensive radiotherapy.
  • RESULTS: The actuarial rate of neck disease control was 68.8% at 5 years (95% confidence interval [CI], 58.9%-78.7%).
  • On multivariate analysis, the rate of neck disease control was significantly related to lymph nodal metastatic level (P = .006).
  • The actuarial rate of developing head and neck primary tumors at 5 years was 8.9% (95% CI, 2.6%-15.2%).
  • CONCLUSIONS: Our study seems to support the use of combined-modality therapy in patients with neck metastases from carcinoma of occult primary.
  • [MeSH-major] Adenocarcinoma / secondary. Carcinoma, Squamous Cell / secondary. Head and Neck Neoplasms / secondary. Neoplasms, Unknown Primary / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Humans. Lymph Nodes / pathology. Lymph Nodes / surgery. Lymphatic Metastasis / pathology. Male. Middle Aged. Neck Dissection. Neoplasm Staging. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 17508250.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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80. Koo BS, Choi EC, Yoon YH, Kim DH, Kim EH, Lim YC: Predictive factors for ipsilateral or contralateral central lymph node metastasis in unilateral papillary thyroid carcinoma. Ann Surg; 2009 May;249(5):840-4
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  • OBJECTIVES: To investigate the incidence and the risk factors for occult ipsilateral or contralateral central neck lymph node (LN)metastasis in patients with unilateral papillary thyroid carcinoma (PTC) and a clinically negative neck.
  • There have been few prospective studies assessing accurate histopathologic information and predictive factors for the presence of metastasis to the ipsilateral or contralateral central compartment of the neck in patients with PTC and clinically negative neck nodes.
  • The relationships between LN metastasis to the ipsilateral or contralateral central neck compartment and clinico-pathologic factors such as age, sex, size of primary tumor, perithyroidal invasion, lymphovascular invasion, and capsular invasion were analyzed.
  • RESULTS: Occult central neck LN metastasis was present in 54.1% (60/111).
  • CONCLUSIONS: Unilateral PTC with a maximal diameter of greater than 1 cm is associated with a high rate of ipsilateral central neck LN metastasis.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Lymph Nodes / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Incidence. Lymph Node Excision / statistics & numerical data. Lymphatic Metastasis. Male. Middle Aged. Neck. Risk Factors. Thyroidectomy. Young Adult

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  • (PMID = 19387316.001).
  • [ISSN] 1528-1140
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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81. Bastaki J, Summersgill K: Signet-ring cell (mucin-producing) adenocarcinoma of minor salivary glands: report of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Oct;110(4):e33-6
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  • [Title] Signet-ring cell (mucin-producing) adenocarcinoma of minor salivary glands: report of a case.
  • Salivary gland tumors account for a significant group of head and neck neoplasms.
  • Signet-ring cell (mucin-producing) adenocarcinoma of minor salivary glands was described by Ghannoum and Freedman in 2004.
  • We report a case of this extremely rare minor salivary gland neoplasm in an 18-year-old male.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoma, Signet Ring Cell / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • [Copyright] Copyright © 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20868985.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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82. Warnecke KK, Sieg P: [Sebaceous carcinoma of the eyelids--case reports and review of the literature]. Klin Monbl Augenheilkd; 2006 Sep;223(9):771-4
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  • As with most skin tumours the predominant region of occurrence is the head and neck, in particular the eyelids.
  • The time span from initial treatment up to definite diagnosis and treatment was one year.
  • In the second case a lymph node metastasis of the parotid gland was found seven years after initial therapy and surgically removed followed by a complete parotidectomy and neck dissection.
  • DISCUSSION: As the sebaceous carcinomas are difficult to differentiate from other kinds of benign and malignant eyelid diseases, a considerable delay between the initial examination and final diagnosis is not uncommon.
  • Depending on preoperative findings, neck dissection may be indicated.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Eyelid Neoplasms / pathology. Eyelid Neoplasms / surgery. Skin Neoplasms / pathology

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  • (PMID = 16986089.001).
  • [ISSN] 0023-2165
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 28
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83. Gillespie MB, Day TA, Sharma AK, Brodsky MB, Martin-Harris B: Role of mitomycin in upper digestive tract stricture. Head Neck; 2007 Jan;29(1):12-7
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  • BACKGROUND: Mitomycin C is an anti-fibroblast chemotherapeutic agent that has demonstrated promise in the treatment of head and neck cancer-related cervical stenosis.
  • The present study investigates whether the application of mitomycin C at the time of dilation is both safe and effective in the treatment of head and neck cancer-related upper digestive tract stricture.
  • METHODS: Twelve patients with progressive dysphagia and video-fluoroscopic evidence of upper digestive tract stricture after head and neck cancer treatment were dilated by Maloney or Savory dilators followed by the application of mitomycin C (0.2 mg/0.4 mL saline) to the stenotic segment for 5 minutes.
  • CONCLUSION: Mitomycin application appears to be a safe and potentially effective treatment for head and neck cancer-related upper digestive tract stricture.
  • [MeSH-minor] Adenocarcinoma / complications. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / complications. Dilatation / instrumentation. Female. Follow-Up Studies. Head and Neck Neoplasms / complications. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 17022087.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 50SG953SK6 / Mitomycin
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84. Peña S, Loehn B, Robertson H, Walvekar RR: Thyroid hemiagenesis: report of a case and review of the literature. Laryngoscope; 2010;120 Suppl 4:S174

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: Our objective was to report an incidental finding of thyroid hemiagenesis in a patient who presented with a left neck mass, present a review of literature, and to discuss management of this diagnosis.
  • RESULTS: A 55 year old woman with a left neck mass presented to our service.
  • A diagnostic CT scan of the head and neck revealed an unrelated finding of an absent left thyroid lobe.
  • The neck mass was pathologically a granulomatous lesion on surgical pathology.
  • Pathology that can be associated in the remnant thyroid lobe includes adenocarcinoma, adenoma, multinodular goiter, and chronic thyroiditis.
  • [MeSH-major] Thyroid Dysgenesis / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Thyroid Function Tests. Thyroid Neoplasms / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 21225772.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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85. Lee YS, Lim YS, Lee JC, Wang SG, Kim IJ, Lee BJ: Clinical implication of the number of central lymph node metastasis in papillary thyroid carcinoma: preliminary report. World J Surg; 2010 Nov;34(11):2558-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: We reviewed the patients who underwent total thyroidectomy and CLN dissection with or without lateral neck dissection due to PTC, from March 2008 to June 2009.
  • Extrathyroidal extension and lateral neck lymph node metastasis were related to increased rate of CLN metastasis (P < 0.05).
  • When evaluating the distribution of lateral neck lymph node metastasis, groups B and C had significant odds ratio (14.353, 75.403, respectively, P < 0.05).
  • CONCLUSIONS: The number of CLN metastasis correlated with the negative prognostic factors, including tumor size, extrathyroidal extension, and lateral neck lymph node metastasis.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Lymph Nodes / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged. Neck Dissection. Prognosis. Retrospective Studies. Risk Factors. Thyroidectomy

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  • (PMID = 20703463.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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86. Lima RA, Tavares MR, Dias FL, Kligerman J, Nascimento MF, Barbosa MM, Cernea CR, Soares JR, Santos IC, Salviano S: Clinical prognostic factors in malignant parotid gland tumors. Otolaryngol Head Neck Surg; 2005 Nov;133(5):702-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical prognostic factors in malignant parotid gland tumors.
  • OBJECTIVE: To analyze the factors in parotid malignant epithelial tumors influencing recurrences and disease-specific survival.
  • Thirty-three patients were treated with parotidectomy plus neck dissection.
  • Neck lymph node metastasis was found in 22 patients, 5 patients had occult neck metastasis, and 4 periparotid lymph nodes metastasis.
  • RESULTS: Forty patients had mucoepidermoid carcinoma, 18 patients adenocarcinoma NOS, 18 patients acinic cell carcinoma, 15 patients adenoid cystic carcinoma, 11 patients malignant mixed tumor, 11 patients salivary duct carcinoma, and 13 patients other pathology.
  • Twenty-five patients had recurrences: 17 had local recurrences, 4 patients had neck recurrences, and 4 were loco-regional recurrences.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / therapy. Neoplasm Invasiveness / pathology. Parotid Neoplasms / mortality. Parotid Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Child. Child, Preschool. Cohort Studies. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Multivariate Analysis. Neck Dissection / methods. Neoplasm Staging. Parotid Gland / radiation effects. Parotid Gland / surgery. Probability. Proportional Hazards Models. Radiotherapy, Adjuvant. Retrospective Studies. Risk Assessment. Sex Factors. Survival Analysis. Time Factors. Treatment Outcome

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  • (PMID = 16274796.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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87. Holmila R, Bornholdt J, Suitiala T, Cyr D, Dictor M, Steiniche T, Wolff H, Wallin H, Luce D, Husgafvel-Pursiainen K: Profile of TP53 gene mutations in sinonasal cancer. Mutat Res; 2010 Apr 1;686(1-2):9-14
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  • Genetic alterations underlying the development of the cancer of the nose and paranasal sinuses (sinonasal cancer, SNC), a rare cancer that can be included in the group of head and neck cancers, are still largely unknown.
  • We recently reported that TP53 mutations are a common feature of SNC, with an overall frequency of 77%, and they show association to adenocarcinoma and wood-dust exposure [15].
  • G-->T transversions occurred at a frequency of 10% (12/125), which is less than reported in mutation databases for head and neck squamous cell carcinoma (24%).
  • Codon 135 was the second most frequently mutated codon; this nucleotide position has not been reported before as frequently mutated in head and neck cancer or human cancer in general.

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  • [Copyright] Copyright 2009 Elsevier B.V. All rights reserved.
  • (PMID = 20025891.001).
  • [ISSN] 0027-5107
  • [Journal-full-title] Mutation research
  • [ISO-abbreviation] Mutat. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Air Pollutants
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88. Heeger S: Targeted therapy of the epidermal growth factor receptor in the treatment of pancreatic cancer. Recent Results Cancer Res; 2008;177:131-6
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  • The so-called "small molecule" tyrosine kinase inhibitor erlotinib has gained marketing authorization in the United States for advanced adenocarcinoma of the lung and for pancreatic cancer, whereas the antibody cetuximab is registered for metastatic colorectal cancer and cancers of the head and neck.

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  • (PMID = 18084955.001).
  • [ISSN] 0080-0015
  • [Journal-full-title] Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer
  • [ISO-abbreviation] Recent Results Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
  • [Number-of-references] 28
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89. Papadogeorgakis N, Petsinis V, Goutzanis L, Kostakis G, Alexandridis C: Parapharyngeal space tumors: surgical approaches in a series of 13 cases. Int J Oral Maxillofac Surg; 2010 Mar;39(3):243-50
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  • Tumors originating in the parapharyngeal space are rare; they comprise approximately 0.5% of head and neck tumors.
  • The aim of this study is to present the surgical procedures used for the treatment of 13 patients with parapharyngeal space tumors; 11 of them were suffering from benign tumors (the most frequent being pleomorphic adenoma; 8 cases) and 2 from malignant lesions.
  • The type of surgical approach was dictated by the type of the lesion (malignant or benign), the exact location, the size, the vascularity and the relation of the tumor to the neck neurovascular bundle.
  • [MeSH-major] Head and Neck Neoplasms / surgery. Pharyngeal Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / surgery. Adenoma, Pleomorphic / surgery. Adult. Aged. Biopsy, Fine-Needle. Deglutition Disorders / diagnosis. Disease-Free Survival. Female. Follow-Up Studies. Humans. Lip / surgery. Magnetic Resonance Imaging. Male. Mandible / surgery. Middle Aged. Mouth / surgery. Neck / surgery. Osteotomy / classification. Osteotomy / methods. Postoperative Complications. Radiotherapy, Adjuvant. Sarcoma, Synovial / surgery. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 20005672.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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90. Somali I, Yersal O, Kilçiksiz S: Infratemporal fossa and maxillary sinus metastases from colorectal cancer: a case report. J BUON; 2006 Jul-Sep;11(3):363-5
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  • Head and neck metastases from colorectal carcinoma are very rare.
  • Computed tomography (CT) of the head and neck showed a gross mass involving the sphenoid sinus, left maxillary sinus, left pterygopalatine plate, pterygopalatine and infratemporal fossa.
  • Histology of the mass revealed metastatic adenocarcinoma which was similar with the primary sigmoid carcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Colorectal Neoplasms / pathology. Cranial Fossa, Middle. Maxillary Sinus Neoplasms / secondary. Skull Base Neoplasms / secondary

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  • (PMID = 17309165.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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91. Momm F, Volegova-Neher NJ, Schulte-Mönting J, Guttenberger R: Different saliva substitutes for treatment of xerostomia following radiotherapy. A prospective crossover study. Strahlenther Onkol; 2005 Apr;181(4):231-6
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  • BACKGROUND AND PURPOSE: Xerostomia is an important chronic side effect of radiotherapy in the head and neck area.
  • PATIENTS AND METHODS: In 120 patients with xerostomia after radiotherapy for head and neck cancer, four different saliva substitute compounds (gel, carmellose spray, oil, mucin spray) were tested in a prospective crossover design.
  • [MeSH-major] Head and Neck Neoplasms / radiotherapy. Radiotherapy / adverse effects. Saliva, Artificial / therapeutic use. Xerophthalmia / drug therapy. Xerophthalmia / etiology
  • [MeSH-minor] Adenocarcinoma / radiotherapy. Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / radiography. Choice Behavior. Cross-Over Studies. Female. Humans. Lymphoma / radiotherapy. Male. Middle Aged. Radiotherapy Dosage. Treatment Outcome

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  • (PMID = 15827692.001).
  • [ISSN] 0179-7158
  • [Journal-full-title] Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
  • [ISO-abbreviation] Strahlenther Onkol
  • [Language] eng
  • [Publication-type] Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Saliva, Artificial
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92. Iqbal FR, Sani A, Gendeh BS, Aireen I: Triple primary cancers of the larynx, lung and thyroid presenting in one patient. Med J Malaysia; 2008 Dec;63(5):417-8
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  • Patients with multiple malignant primary tumours are often described, based on their chronology of presentation, as simultaneous, synchronous or metachronous tumours.
  • Lung malignancies presenting in association with head and neck tumours are well documented while there have been small series of thyroid synchronous cancers presenting with laryngeal lesions in literature.
  • We also discuss screening for lung and thyroid malignancies in patients with head and neck squamous cell carcinoma (SCC).
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Papillary / diagnosis. Carcinoma, Squamous Cell / diagnosis. Laryngeal Neoplasms / diagnosis. Lung Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Thyroid Neoplasms / diagnosis

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  • (PMID = 19803306.001).
  • [ISSN] 0300-5283
  • [Journal-full-title] The Medical journal of Malaysia
  • [ISO-abbreviation] Med. J. Malaysia
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Malaysia
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93. Chazono H, Okamoto Y, Matsuzaki Z, Horiguchi S, Matsuoka T, Horikoshi T, Nukui H, Hadeishi H, Yasui N: Carotid artery resection: preoperative temporary occlusion is not always an accurate predictor of collateral blood flow. Acta Otolaryngol; 2005 Feb;125(2):196-200
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: Carotid artery resection is generally considered the only curative treatment for patients with advanced head and neck carcinoma involving the carotid artery.
  • MATERIAL AND METHODS: Twelve patients diagnosed with head and neck cancer adherent to the carotid artery and in proximity to the skull base who had shown good hemispheric collateral blood flow by means of PET underwent carotid artery resection without preoperative bypass.
  • [MeSH-minor] Adenocarcinoma / blood supply. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adult. Aged. Balloon Occlusion / instrumentation. Carcinoma, Squamous Cell / blood supply. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Cerebral Revascularization / methods. Female. Humans. Male. Maxillary Sinus / blood supply. Maxillary Sinus / pathology. Maxillary Sinus / surgery. Middle Aged. Neoplasm Invasiveness / pathology. Paranasal Sinus Neoplasms / blood supply. Paranasal Sinus Neoplasms / pathology. Paranasal Sinus Neoplasms / surgery. Parotid Neoplasms / blood supply. Parotid Neoplasms / pathology. Parotid Neoplasms / surgery. Predictive Value of Tests. Risk Assessment. Vascular Neoplasms / blood supply. Vascular Neoplasms / pathology. Vascular Neoplasms / surgery

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  • (PMID = 15880953.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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94. Varty PP, Yamamoto H, Farges O, Belghiti J, Sauvanet A: Early retropancreatic dissection during pancreaticoduodenectomy. Am J Surg; 2005 Apr;189(4):488-91
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  • BACKGROUND: During pancreaticoduodenectomy, early neck division may be inadequate, particularly in cases of replaced or accessory right hepatic artery (RHA) or diffuse intraductal papillary and mucinous neoplasm (IPMN) or when invasion of superior mesenteric artery is suspected.
  • METHODS: Modification of the technique of pancreaticoduodenectomy with dissection of the superior mesenteric vessels performed from behind the head of the pancreas before any pancreatic or digestive transection.
  • The pancreas is divided later, after adequate mobilization of the specimen from the vessels, on either the neck or the body, according to underlying disease.
  • Additionally, we used this technique in 18 patients with IPMN-14 pancreaticoduodenectomies extended to the body and 4 total pancreatectomies-and in 3 patients with adenocarcinoma involving the porto-mesenteric confluence and needing en-bloc vascular resection.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / surgery. Cystadenoma, Papillary / surgery. Neoplasm Invasiveness / pathology. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Cohort Studies. Dissection / methods. Female. Hepatic Artery / pathology. Hepatic Artery / surgery. Humans. Male. Mesenteric Arteries / pathology. Mesenteric Arteries / surgery. Neoplasm Staging. Retroperitoneal Space / surgery. Risk Assessment. Sensitivity and Specificity. Treatment Outcome

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  • (PMID = 15820467.001).
  • [ISSN] 0002-9610
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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95. Shtilbans V, Wu M, Burstein DE: Current overview of the role of Akt in cancer studies via applied immunohistochemistry. Ann Diagn Pathol; 2008 Apr;12(2):153-60
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  • The following review summarizes the use of phospho-AKT immunohistochemistry as a potentially valuable tool in cancer prognostication in a wide spectrum of common and uncommon malignancies, including squamous carcinoma of cervix and of head and neck; adenocarcinoma of endometrium, ovarian, breast, prostate, kidney, colon, and pancreas; carcinomas of lung and thyroid; and hematopoietic, soft tissue, and central nervous system neoplasms.
  • To date, the findings overall suggest that the major use of p-AKT immunohistochemical staining lies in prognostication and possibly in individualization of therapy rather than in differential diagnosis.

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  • (PMID = 18325479.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
  • [Number-of-references] 79
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96. Naramoto H, Uematsu T, Uchihashi T, Doto R, Matsuura T, Usui Y, Uematsu S, Li X, Takahashi M, Yamaoka M, Furusawa K: Multidrug resistance-associated protein 7 expression is involved in cross-resistance to docetaxel in salivary gland adenocarcinoma cell lines. Int J Oncol; 2007 Feb;30(2):393-401
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  • [Title] Multidrug resistance-associated protein 7 expression is involved in cross-resistance to docetaxel in salivary gland adenocarcinoma cell lines.
  • The aim of the present study was to clarify whether ATP binding cassette transporters are refractory factors in head and neck cancers.
  • For in vitro and in vivo chemotherapeutic studies, we used the following head and neck cancer cell lines: a mouse oral squamous cell carcinoma (SCC) cell line, Sq-1979; a human SCC cell line, SCCHA; a mouse salivary gland adenocarcinoma (SGA) cell line, NR-PG; and a human SGA cell line, HSY.
  • These results indicate that MDR1 expression, MRP1 expression, and MRP7 expression are refractory factors in head and neck cancer chemotherapy and suggest that induction of MRP7 expression is involved in drug resistance to natural products, especially to docetaxel in SGA.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Agents / pharmacology. Drug Resistance, Multiple. Gene Expression Regulation, Neoplastic. Multidrug Resistance-Associated Proteins / biosynthesis. Salivary Gland Neoplasms / drug therapy. Taxoids / pharmacology
  • [MeSH-minor] Animals. Cell Line, Tumor. Estradiol / analogs & derivatives. Estradiol / pharmacology. Female. Head and Neck Neoplasms. Humans. Immunohistochemistry. Mice. Mice, Nude. Neoplasm Transplantation. RNA, Messenger / metabolism

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  • (PMID = 17203221.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / ABCC10 protein, human; 0 / Antineoplastic Agents; 0 / Multidrug Resistance-Associated Proteins; 0 / RNA, Messenger; 0 / Taxoids; 15H5577CQD / docetaxel; 1806-98-0 / estradiol-17 beta-glucuronide; 4TI98Z838E / Estradiol
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97. Warchoł R, Szymański L, Seichter A: [Rectal adenocarcinoma metastasis to the facial skin--case report]. Otolaryngol Pol; 2008;62(1):96-9
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  • [Title] [Rectal adenocarcinoma metastasis to the facial skin--case report].
  • In a very few cases its spread seems unpredictable and can cause a distant metastasis to head and neck region.
  • Histopatological examination of specimen from the facial skin lesion revealed adenocarcinoma cells.
  • RESULTS AND CONCLUSIONS: We present this case report as an example of an unusual and rare secondary malignancy of head and neck, emphasizing the interdisciplinary character of oncological treatment and the role of oncological vigilance on every step of diagnosis.
  • [MeSH-major] Adenocarcinoma / secondary. Facial Neoplasms / secondary. Rectal Neoplasms / pathology. Skin Neoplasms / secondary

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  • (PMID = 18637429.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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98. Soler ZM, Hamilton BE, Schuff KG, Samuels MH, Cohen JI: Utility of computed tomography in the detection of subclinical nodal disease in papillary thyroid carcinoma. Arch Otolaryngol Head Neck Surg; 2008 Sep;134(9):973-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PATIENTS: Consecutive patients undergoing neck dissection for PTC between July 1, 2004, and July 1, 2006.
  • INTERVENTION: Preoperative CT scans were reevaluated in a blinded fashion by a single head and neck radiologist.
  • RESULTS: One hundred four patients underwent selective neck dissection for PTC during the study period.
  • [MeSH-major] Adenocarcinoma, Papillary / radiography. Thyroid Neoplasms / radiography. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Chi-Square Distribution. Female. Humans. Lymphatic Metastasis / radiography. Male. Middle Aged. Neck Dissection. Predictive Value of Tests. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 18794443.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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99. Moffatt-Bruce SD, Ross P, Leon ME, He G, Finkelstein SD, Vaida AM, Iwenofu OH, Frankel WL, Hitchcock CL: Comparative mutational profiling in the assessment of lung lesions: should it be the standard of care? Ann Thorac Surg; 2010 Aug;90(2):388-96
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We sought to review our experience in cases of two lung lesions or head and neck cancer and lung lesions to determine whether a significantly clinical problem existed, what standard processes were in place to address it, and whether a new diagnostic standard was required.
  • METHODS: Between January 1, 2007, and October 31, 2008, CMP was used in 24 cases of two lung lesions or a head and neck cancer and lung lesion.
  • The cases involved two lung lesions (n = 13) or a head and neck cancer and a lung lesion (n = 11).
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / genetics. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / genetics. Lung Neoplasms / diagnosis. Lung Neoplasms / genetics. Mutation
  • [MeSH-minor] Aged. Aged, 80 and over. DNA Fingerprinting. Diagnosis, Differential. Female. Head and Neck Neoplasms / pathology. Humans. Male. Middle Aged. Neoplasms, Multiple Primary / diagnosis. Retrospective Studies

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  • [Copyright] Copyright 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • [CommentIn] Ann Thorac Surg. 2010 Aug;90(2):397 [20667317.001]
  • (PMID = 20667316.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
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100. Agrawal AR, Nair N: Unusual metastasis of poorly differentiated thyroid carcinoma to the masticator space. Clin Nucl Med; 2007 Jul;32(7):516-8
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  • A CT scan of the head and neck revealed a heterogeneous, hypervascular mass in the left masticator space.
  • [MeSH-major] Adenocarcinoma, Papillary / diagnosis. Adenocarcinoma, Papillary / secondary. Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / secondary. Stomatognathic Diseases / diagnosis. Thyroid Neoplasms / diagnosis

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  • (PMID = 17581333.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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