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1. Hwang KG, Park CJ, Paik SS, Shim KS: Gingival metastasis from gastric adenocarcinoma. Otolaryngol Head Neck Surg; 2007 Jul;137(1):169-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gingival metastasis from gastric adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Gingival Neoplasms / secondary. Stomach Neoplasms / pathology

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  • (PMID = 17599589.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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2. Sato T, Kawabata Y, Kobayashi Y, Suenaga S, Indo H, Kawano K, Iwashita Y, Morita Y, Majima HJ: Scintigraphy for interpretation of malignant tumours of the head and neck: comparison of technetium-99m-hexakis-2-methoxyisobutylisonitrile (Tc-MIBI) and thallium-201-chloride (Tl-201). Dentomaxillofac Radiol; 2005 Sep;34(5):268-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Scintigraphy for interpretation of malignant tumours of the head and neck: comparison of technetium-99m-hexakis-2-methoxyisobutylisonitrile (Tc-MIBI) and thallium-201-chloride (Tl-201).
  • METHODS: Dynamic and static scintigraphic imaging with 99Tc(m)-MIBI and Tl-201 were performed on patients with a variety of malignant and benign tumours.
  • In addition to these factors, the grade of tissue differentiation and tumour size were evaluated to clarify the difference between 99Tc(m)-MIBI and Tl-201 for the diagnosis of malignant tumours of the head and neck.
  • CONCLUSIONS: There was no major difference between 99Tc(m)-MIBI and Tl-201scintigraphy with respect to accuracy of diagnosis of malignant tumours of the head and neck.
  • [MeSH-major] Carcinoma, Squamous Cell / radionuclide imaging. Head and Neck Neoplasms / radionuclide imaging. Radiopharmaceuticals. Technetium Tc 99m Sestamibi. Thallium Radioisotopes
  • [MeSH-minor] Adenocarcinoma / radionuclide imaging. Adenolymphoma / radionuclide imaging. Adenoma, Pleomorphic / radionuclide imaging. Adult. Aged. Aged, 80 and over. Cell Differentiation. Female. Humans. Male. Middle Aged. Regional Blood Flow / physiology. Retrospective Studies. Thallium. Time Factors

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  • (PMID = 16120875.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0 / Thallium Radioisotopes; 7791-12-0 / thallium chloride; 971Z4W1S09 / Technetium Tc 99m Sestamibi; AD84R52XLF / Thallium
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3. Wang YM, Wang R, Wen DG, Li Y, Guo W, Wang N, Wei LZ, He YT, Chen ZF, Zhang XF, Zhang JH: Single nucleotide polymorphism in DNA methyltransferase 3B promoter and its association with gastric cardiac adenocarcinoma in North China. World J Gastroenterol; 2005 Jun 21;11(23):3623-7
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  • [Title] Single nucleotide polymorphism in DNA methyltransferase 3B promoter and its association with gastric cardiac adenocarcinoma in North China.
  • AIM: To investigate the association between single nucleotide polymorphism (SNP) in promoter of the DNA methyltransferase 3B (DNMT3B) gene and risk for development and lymphatic metastasis of gastric cardiac adenocarcinoma (GCA).
  • Although this SNP has been associated with susceptibility to lung, head, neck and breast cancer, it may not be used as a stratification marker to predict susceptibility and lymphatic metastasis of GCA, at least in the population of North China.

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  • (PMID = 15962389.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] ENG
  • [Grant] United States / NIH HHS / JT / C2000062
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.1.1.37 / DNA (Cytosine-5-)-Methyltransferase; EC 2.1.1.37 / DNA methyltransferase 3B
  • [Other-IDs] NLM/ PMC4315975
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4. Lu J, Frater JL, Kreisel FH, Marcus JN, Hassan A: Secondary lymphoma involving metastatic follicular thyroid carcinoma to the skull: a unique example of tumor-to-tumor metastasis. Head Neck Pathol; 2008 Sep;2(3):209-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma, Follicular / secondary. Lymphoma / pathology. Neoplasms, Second Primary / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Combined Modality Therapy. Female. Humans. Middle Aged. Neoplasm Metastasis. Salvage Therapy

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  • (PMID = 20614316.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2807566
  • [Keywords] NOTNLM ; Large cell lymphoma / Non-Hodgkin’s lymphoma / Skull metastasis / Thyroid carcinoma / Thyroid follicular carcinoma / Tumor-to-tumor metastasis
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5. Shaha A: Treatment of thyroid cancer based on risk groups. J Surg Oncol; 2006 Dec 15;94(8):683-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenocarcinoma, Follicular / pathology. Aged. Biopsy, Fine-Needle. Brain Neoplasms / secondary. Carcinoma, Papillary / secondary. Diagnosis, Differential. Female. Humans. Incidental Findings. Lymph Nodes / pathology. Lymphatic Metastasis. Male. Middle Aged. Prognosis. Risk Assessment. Survival Rate. Treatment Outcome

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  • (PMID = 17131422.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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6. Sheahan P, Toner M, Timon CV: Clinicopathological features of head and neck adenosquamous carcinoma. ORL J Otorhinolaryngol Relat Spec; 2005;67(1):10-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathological features of head and neck adenosquamous carcinoma.
  • Adenosquamous carcinoma is a rare tumour which is characterized pathologically by the simultaneous presence of distinct areas of squamous cell carcinoma and adenocarcinoma.
  • In the present study, the medical and pathological records of 4 patients with head and neck adenosquamous carcinoma are reviewed.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Head and Neck Neoplasms / pathology

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  • [Copyright] Copyright (c) 2005 S. Karger AG, Basel.
  • (PMID = 15637416.001).
  • [ISSN] 0301-1569
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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7. Pogodzinski MS, Sabri AN, Lewis JE, Olsen KD: Retrospective study and review of polymorphous low-grade adenocarcinoma. Laryngoscope; 2006 Dec;116(12):2145-9
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  • [Title] Retrospective study and review of polymorphous low-grade adenocarcinoma.
  • OBJECTIVES/HYPOTHESIS: We review a single institution's experience with polymorphous low-grade adenocarcinoma.
  • To our knowledge, this is the largest patient series of polymorphous low-grade adenocarcinoma with clinical follow-up in the otolaryngology literature.
  • STUDY DESIGN: We retrospectively identified 19 patients with polymorphous low-grade adenocarcinoma who had adequate clinical follow-up and pathologic specimens available for examination.
  • METHODS: All pathologic materials were reviewed by one head and neck pathologist.
  • The most common initial diagnoses were polymorphous low-grade adenocarcinoma, adenoid cystic carcinoma, and pleomorphic adenoma.
  • CONCLUSIONS: Polymorphous low-grade adenocarcinoma is an increasingly recognized malignancy that originates predominantly in the minor salivary gland.
  • [MeSH-major] Adenocarcinoma / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Retrospective Studies. Salivary Glands, Minor


8. Cavicchi O, Piccin O, Caliceti U, De Cataldis A, Pasquali R, Ceroni AR: Transient hypoparathyroidism following thyroidectomy: a prospective study and multivariate analysis of 604 consecutive patients. Otolaryngol Head Neck Surg; 2007 Oct;137(4):654-8
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  • SUBJECTS AND METHODS: Gender, final diagnosis, extent of resection, biology of pathology, intrathoracic involvement, surgery for recurrent multinodular goiter, and presence and number of parathyroid glands in a surgical specimen were analyzed as risk factors for postoperative transient hypoparathyroidism.
  • CONCLUSION: The extent of surgery to central and/or lateral neck lymph nodes is responsible for a high rate of transient hypoparathyroidism owing to a high probability of unplanned parathyroidectomy or parathyroid gland devascularization.
  • [MeSH-minor] Adenocarcinoma, Follicular / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Papillary / surgery. Child. Female. Follow-Up Studies. Goiter, Nodular / surgery. Goiter, Substernal / surgery. Graves Disease / surgery. Humans. Male. Middle Aged. Neck Dissection / adverse effects. Parathyroidectomy / adverse effects. Prospective Studies. Recurrence. Reoperation. Risk Factors. Thyroid Neoplasms / surgery

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  • (PMID = 17903586.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Hertel V, Bozzato A, Alexiou C: [Unilateral neck mass, dysphagia and dyspnea]. HNO; 2010 Aug;58(8):818-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Unilateral neck mass, dysphagia and dyspnea].
  • Extraocular sebaceous carcinoma is a rare malignant tumor, arising from skin and salivary glands.
  • An important differential diagnosis in the head and neck region is metastasizing squamous cell carcinoma.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Deglutition Disorders / etiology. Dyspnea / etiology. Head and Neck Neoplasms / diagnosis. Hypopharyngeal Neoplasms / diagnosis. Sebaceous Gland Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biopsy. Diagnosis, Differential. Endoscopy. Humans. Keratin-5 / analysis. Male. Pyriform Sinus / pathology. Pyriform Sinus / surgery. Surgical Flaps. Tomography, X-Ray Computed. Tracheotomy. Ultrasonography


10. Mijović T, Rochon L, Gologan O, Hier MP, Black MJ, Young J, Payne RJ: Fine-needle aspiration biopsies in the management of indeterminate follicular and Hurthle cell thyroid lesions. Otolaryngol Head Neck Surg; 2009 May;140(5):715-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Adenoma, Oxyphilic / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 19393417.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Sun TQ, Wu Y, Ji QH, Bian JC, Wang ZY: [Somatic mutations of mitochondrial DNA in thyroid papillary carcinoma]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2006 Oct;41(10):782-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma, Papillary / genetics. DNA, Mitochondrial / genetics. Mutation. Thyroid Neoplasms / genetics

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  • (PMID = 17190430.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA, Mitochondrial
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12. Li M, Jin Y, Sun WJ, Yu Y, Bai J, Tong DD, Qi JP, Du JR, Geng JS, Huang Q, Huang XY, Huang Y, Han FF, Meng XN, Rosales JL, Lee KY, Fu SB: Reduced expression and novel splice variants of ING4 in human gastric adenocarcinoma. J Pathol; 2009 Sep;219(1):87-95
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  • [Title] Reduced expression and novel splice variants of ING4 in human gastric adenocarcinoma.
  • ING4, a new member of the ING (inhibitor of growth) family of tumour suppressor genes, has been found to be deleted or down-regulated in gliomas, breast tumours, and head and neck squamous cell carcinomas.
  • The goal of the present study was to investigate whether the expression and alternative splicing of ING4 transcripts are involved in the initiation and progression of stomach adenocarcinoma.
  • ING4 mRNA and protein expression was examined in gastric adenocarcinoma tissues and human gastric adenocarcinoma cell lines by RT-PCR, real-time RT-PCR, tissue microarray immunohistochemistry, and western blot analysis.
  • Our data showed that ING4 mRNA and protein were dramatically reduced in stomach adenocarcinoma cell lines and tissues, and significantly less in female than in male patients.
  • These variants cause a codon frame-shift and, eventually, deletion of the NLS or PHD domain contributing to the mislocalization of p53 and/or HAT/HDAC complexes and, subsequently, altered gene expression in gastric adenocarcinoma.
  • These results suggest that attenuated and aberrant ING4 expression may be involved in the initiation and progression of stomach adenocarcinoma.

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  • (PMID = 19479822.001).
  • [ISSN] 1096-9896
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] ENG
  • [Grant] None / None / / 82788-1; Canada / Canadian Institutes of Health Research / / 82788-1
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / Homeodomain Proteins; 0 / ING4 protein, human; 0 / RNA, Messenger; 0 / Tumor Suppressor Proteins
  • [Other-IDs] NLM/ CAMS3767; NLM/ PMC3855470
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13. Pultrum BB, Bosch DJ, Nijsten MW, Rodgers MG, Groen H, Slaets JP, Plukker JT: Extended esophagectomy in elderly patients with esophageal cancer: minor effect of age alone in determining the postoperative course and survival. Ann Surg Oncol; 2010 Jun;17(6):1572-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma / surgery. Esophageal Neoplasms / surgery. Esophagectomy. Frail Elderly

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  • (PMID = 20180031.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2868167
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14. Shtilbans V, Wu M, Burstein DE: Current overview of the role of Akt in cancer studies via applied immunohistochemistry. Ann Diagn Pathol; 2008 Apr;12(2):153-60
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  • The following review summarizes the use of phospho-AKT immunohistochemistry as a potentially valuable tool in cancer prognostication in a wide spectrum of common and uncommon malignancies, including squamous carcinoma of cervix and of head and neck; adenocarcinoma of endometrium, ovarian, breast, prostate, kidney, colon, and pancreas; carcinomas of lung and thyroid; and hematopoietic, soft tissue, and central nervous system neoplasms.
  • To date, the findings overall suggest that the major use of p-AKT immunohistochemical staining lies in prognostication and possibly in individualization of therapy rather than in differential diagnosis.

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  • (PMID = 18325479.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
  • [Number-of-references] 79
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15. Gil Z, Kelly KJ, Brader P, Shah JP, Fong Y, Wong RJ: Utility of a herpes oncolytic virus for the detection of neural invasion by cancer. Neoplasia; 2008 Apr;10(4):347-53
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  • Prostate, pancreatic, and head and neck carcinomas have a high propensity to invade nerves.
  • This method may improve the diagnosis and treatment of patients with neurotrophic cancers by reducing injury to normal nerves and facilitating identification of infiltrated nerves requiring resection.

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  • (PMID = 18392138.001).
  • [ISSN] 1476-5586
  • [Journal-full-title] Neoplasia (New York, N.Y.)
  • [ISO-abbreviation] Neoplasia
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA075416; United States / NCI NIH HHS / CA / R25 CA096945; United States / NCI NIH HHS / CA / R01 CA75416; United States / NCI NIH HHS / CA / R25-CA096945-3
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / enhanced green fluorescent protein; 147336-22-9 / Green Fluorescent Proteins; EC 2.7.10.1 / Protein-Tyrosine Kinases
  • [Other-IDs] NLM/ PMC2288543
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16. Draf C, Schaberg MR, Anand VK, Nyquist G, Hoda S: Radiation induced malignancy in retinoblastoma: new pathology in a case report. Laryngoscope; 2010;120 Suppl 4:S238
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  • OBJECTIVE: Patients with a genetic history of retinoblastoma have an increased risk of developing a second neoplasm.
  • We present the first case of a radiation induced adenocarcinoma in a patient after treatment for retinoblastoma.
  • The patient underwent surgical resection and pathology revealed an adenocarcinoma.
  • This is the first case of a sinonasal adenocarcinoma occurring in the previously irradiated field.
  • The endoscopic skull base surgeon plays a vital role as patient survival depends on the diagnosis and surgical management.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / etiology. Neoplasms, Radiation-Induced / diagnosis. Neoplasms, Second Primary / diagnosis. Neoplasms, Second Primary / etiology. Nose Neoplasms / diagnosis. Nose Neoplasms / etiology. Retinal Neoplasms / radiotherapy. Retinoblastoma / radiotherapy
  • [MeSH-minor] Adult. Diagnosis, Differential. Endoscopy. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 21225836.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Alkhoury F, Martin JT, Fiedler P, Jaffe PE: Esophageal granular cell tumor colliding with intramucosal adenocarcinoma: a case report. Cases J; 2009;2:8093
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  • [Title] Esophageal granular cell tumor colliding with intramucosal adenocarcinoma: a case report.
  • We report a case of a granular cell tumor colliding with intramucosal adenocarcinoma of the esophagus.
  • Endoscopic biopsies revealed intramucosal adenocarcinoma arising in the setting of Barrett's esophagus.
  • The adenocarcinoma infiltrated a granular cell tumor also present at the nodular site.

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  • (PMID = 19830048.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
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  • [Other-IDs] NLM/ PMC2740250
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18. McHugh JB, Hoschar AP, Dvorakova M, Parwani AV, Barnes EL, Seethala RR: p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma. Head Neck Pathol; 2007 Dec;1(2):123-31
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  • Metastatic renal cell carcinoma (RCC) can pose diagnostic challenges in the head and neck often resembling benign and malignant oncocytic lesions.
  • Nineteen oncocytomas, 9 cases of oncocytosis, 9 oncocytic carcinomas and 16 head and neck metastatic RCC were studied.
  • While clinical history and morphology usually are adequate, demonstration of p63 staining can definitively exclude metastatic RCC from the differential diagnosis of similar appearing tumors in salivary glands, namely oncocytoma and oncocytic carcinoma, with 100% specificity and sensitivity.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Adenoma, Oxyphilic / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Membrane Proteins / metabolism. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Predictive Value of Tests

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  • (PMID = 20614263.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / Membrane Proteins
  • [Other-IDs] NLM/ PMC2807526
  • [Keywords] NOTNLM ; Metastatic renal cell carcinoma / Oncocytic carcinoma / Oncocytoma / p63
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19. Thorup C, Sebbesen L, Danø H, Leetmaa M, Andersen M, Buchwald C, Kristensen CA, Bentzen J, Godballe C, Johansen J, Grau C: Carcinoma of the nasal cavity and paranasal sinuses in Denmark 1995-2004. Acta Oncol; 2010 Apr;49(3):389-94
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  • MATERIALS AND METHODS: In the five Danish head and neck oncology centres, charts of all consecutive patients with sino-nasal carcinomas were reviewed and data extracted to a common database.
  • Histologies included squamous cell carcinoma (55%), adenocarcinoma (28.5%), adenoid-cystic carcinoma (5.0%), undifferentiated carcinoma (4.5%), transitiocellular carcinoma (1.7%), mucoepidermoid carcinoma (0.8%), neuroendocrine carcinoma (2.5%), small cell carcinomas (1.2%) and carcinomas not otherwise specified (0.8%).
  • Most failures were in T-site (63, 30%).
  • N-site failures were 10 (5%) and M-site failures six (3%).
  • Failure occurring in T+N-site, T+M-site, N+M-site and T+N+M-site were seven (3%), two (1%), one (0.5%) and five (3%) respectively.
  • Female gender, nasal cavity tumour, adenocarcinoma and low clinical stage were significant positive prognostic factors in univariate analysis.
  • A Cox multivariate analysis showed that only tumour site and clinical stage were independent significant prognostic factors.
  • CONCLUSION: The current series has confirmed stage and tumour site as independent prognostic factors.
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adult. Aged. Aged, 80 and over. Carcinoma, Mucoepidermoid / epidemiology. Carcinoma, Neuroendocrine / epidemiology. Carcinoma, Small Cell / epidemiology. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Transitional Cell / epidemiology. Cystadenocarcinoma / epidemiology. Denmark / epidemiology. Disease-Free Survival. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Multivariate Analysis. Proportional Hazards Models

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  • (PMID = 20001493.001).
  • [ISSN] 1651-226X
  • [Journal-full-title] Acta oncologica (Stockholm, Sweden)
  • [ISO-abbreviation] Acta Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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20. Kalialis LV, Breiting LB, Klausen S, Dahlstrøm K: [Primary mucinous carcinoma of the skin]. Ugeskr Laeger; 2008 Oct 20;170(43):3403-4
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  • Primary mucinous carcinoma of the skin is a rare malignant tumour originating from the sweat glands.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Head and Neck Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Lymphatic Metastasis. Middle Aged. Sweat Gland Neoplasms / pathology. Sweat Gland Neoplasms / secondary. Sweat Gland Neoplasms / surgery

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  • (PMID = 18976594.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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21. Otto KJ, Lam JS, MacMillan C, Freeman JL: Diminishing diagnosis of follicular thyroid carcinoma. Head Neck; 2010 Dec;32(12):1629-34
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  • [Title] Diminishing diagnosis of follicular thyroid carcinoma.
  • [MeSH-major] Adenocarcinoma, Follicular / diagnosis. Thyroid Neoplasms / diagnosis

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  • (PMID = 20848402.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Cheng JH, Huang YC, Kuo C, Lai YS, Wu TC, Tsao TC, Luh SP, Tsai CB: Double primary bronchogenic carcinoma of the lung and papillary thyroid carcinoma: a case report. J Med Case Rep; 2008;2:309
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  • Pathology revealed a well-differentiated adenocarcinoma and the dissected lymph nodes were negative for malignancy.
  • He also complained of a mass in his neck, which had grown slowly for over 5 years.
  • A computed tomography scan of the neck revealed a left thyroid mass compressing the trachea towards the right side.

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  • (PMID = 18811948.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2557019
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23. Freedman ND, Lacey JV Jr, Hollenbeck AR, Leitzmann MF, Schatzkin A, Abnet CC: The association of menstrual and reproductive factors with upper gastrointestinal tract cancers in the NIH-AARP cohort. Cancer; 2010 Mar 15;116(6):1572-81
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  • BACKGROUND: In most populations, incidence rates of upper gastrointestinal (UGI) tract cancers (head and neck, esophagus, and stomach) are higher among men than among women.
  • RESULTS: During follow-up through 2003, 162 incident adenocarcinomas (ACs; esophagus, N = 25, and stomach, N = 137) and 353 incident squamous cell carcinomas (SCCs; head and neck, n = 297, and esophagus, N = 56) occurred.
  • [MeSH-major] Adenocarcinoma / epidemiology. Gastrointestinal Neoplasms / epidemiology. Head and Neck Neoplasms / epidemiology. Menstruation. Reproductive History

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  • (PMID = 20186831.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 CA999999
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS161010; NLM/ PMC2836418
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24. Hoque MO, Brait M, Rosenbaum E, Poeta ML, Pal P, Begum S, Dasgupta S, Carvalho AL, Ahrendt SA, Westra WH, Sidransky D: Genetic and epigenetic analysis of erbB signaling pathway genes in lung cancer. J Thorac Oncol; 2010 Dec;5(12):1887-93
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  • METHODS: We tested three key genetic and epigenetic alterations (EGFR, RASSF1A, and BRAF) of this pathway on a series of primary NSCLC (total 111; adenocarcinoma 49, squamous cell carcinoma [SCC] 48, and others 14).
  • RESULTS: Five EGFR mutations were identified: three in adenocarcinoma (6%), one in SCC (2%), and one in adenocarcinoma with bronchoalveolar component tumor (7%).
  • Mutations of EGFR, BRAF, and KRAS in adenocarcinoma were mutually exclusive and inversely correlated with RASSF1A methylation (p = -0.394; p = 0.007).
  • DISCUSSION: Overall, genetic and/or epigenetic alterations of erbB pathway genes were detected in 80% (39/49) of adenocarcinomas.Approximately half of primary adenocarcinoma harbor molecular alterations of the erbB pathway.

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  • (PMID = 21102258.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA084986-12; United States / NCI NIH HHS / CA / U01 CA084986; United States / NCI NIH HHS / CA / U01 CA084986-12; United States / NCI NIH HHS / CA / U01-CA84986
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / KRAS protein, human; 0 / Oncogene Proteins v-erbB; 0 / Proto-Oncogene Proteins; 0 / RASSF1 protein, human; 0 / Tumor Suppressor Proteins; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / ras Proteins
  • [Other-IDs] NLM/ NIHMS244223; NLM/ PMC3057519
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25. Negahban S, Daneshbod Y, Khademi B, Rasekhi AR, Soleimanpour H: Sinonasal clear cell adenocarcinoma: a case report. Acta Cytol; 2009 Sep-Oct;53(5):597-600
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  • [Title] Sinonasal clear cell adenocarcinoma: a case report.
  • We present cytologic findings of clear cell sinonasal adenocarcinoma and related pitfalls.
  • The mass was reported to be a clear cell neoplasm, and excision of the whole mass was performed.
  • CONCLUSION: Cytologic findings of this rare tumor overlap with those of salivary gland-type tumors with clear cell change and should be added to the list of head and neck tumors with clear cell change.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Nasal Mucosa / pathology. Paranasal Sinus Neoplasms / pathology

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  • (PMID = 19798893.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Grunstein E, Kacker A: Salivary gland cystadenocarcinoma of the mobile tongue, low-grade papillary adenocarcinoma variant: a case report. Ear Nose Throat J; 2006 Dec;85(12):829-30
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  • [Title] Salivary gland cystadenocarcinoma of the mobile tongue, low-grade papillary adenocarcinoma variant: a case report.
  • Cystadenocarcinoma is a rare malignant neoplasm of the salivary gland.
  • Treatment involves local excision; neck dissection and postoperative radiation therapy are used for clinically positive neck metastases.
  • [MeSH-major] Cystadenocarcinoma, Papillary / diagnosis. Salivary Gland Neoplasms / diagnosis

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  • (PMID = 17240709.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Tijink BM, De Bree R, Van Dongen GA, Leemans CR: How we do it: Chemo-electroporation in the head and neck for otherwise untreatable patients. Clin Otolaryngol; 2006 Oct;31(5):447-51
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  • [Title] How we do it: Chemo-electroporation in the head and neck for otherwise untreatable patients.
  • Keypoints * Chemo-electroporation therapy with bleomycin is a locoregional treatment modality for head and neck and skin cancer, with the potential to preserve function.
  • * Based on the outcome of the clinical trial, bleomycin-electroporation therapy has the potential to become a valuable addition to the late-stage treatment options for patients with head and neck or skin tumours.
  • [MeSH-major] Antibiotics, Antineoplastic / therapeutic use. Bleomycin / therapeutic use. Electroporation / methods. Head and Neck Neoplasms / therapy
  • [MeSH-minor] Adenocarcinoma / secondary. Adenocarcinoma / therapy. Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / secondary. Carcinoma, Basal Cell / therapy. Carcinoma, Merkel Cell / secondary. Carcinoma, Merkel Cell / therapy. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / therapy. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Melanoma / secondary. Melanoma / therapy. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Netherlands. Salivary Gland Neoplasms / secondary. Salivary Gland Neoplasms / therapy. Sarcoma / secondary. Sarcoma / therapy. Skin Neoplasms / secondary. Skin Neoplasms / therapy. Treatment Outcome. Tumor Burden / drug effects

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  • (PMID = 17014460.001).
  • [ISSN] 1749-4478
  • [Journal-full-title] Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • [ISO-abbreviation] Clin Otolaryngol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 11056-06-7 / Bleomycin
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28. Soma MA, Albert DM: Cidofovir: to use or not to use? Curr Opin Otolaryngol Head Neck Surg; 2008 Feb;16(1):86-90
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  • Intralesional administration after surgical debulking delivers the medication directly to the site of disease and is thought to have fewer systemic side effects than intravenous infusion.
  • It is known to be nephrotoxic when administered intravenously and there remains concern that cidofovir has carcinogenic potential based on animal studies (mammary adenocarcinoma in rats).
  • [MeSH-minor] Humans. Injections, Intralesional. Neoplasm Recurrence, Local / prevention & control

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  • (PMID = 18197029.001).
  • [ISSN] 1531-6998
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antiviral Agents; 0 / Organophosphonates; 8J337D1HZY / Cytosine; JIL713Q00N / cidofovir
  • [Number-of-references] 30
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29. Saxby AJ, Chin M: Paraneoplastic syndrome in a case of sinonasal adenocarcinoma. Otolaryngol Head Neck Surg; 2009 Oct;141(4):547-8
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  • [Title] Paraneoplastic syndrome in a case of sinonasal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / complications. Nasopharyngeal Neoplasms / complications. Nose Neoplasms / complications. Paraneoplastic Syndromes / etiology

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  • (PMID = 19786233.001).
  • [ISSN] 1097-6817
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Iqbal FR, Sani A, Gendeh BS, Aireen I: Triple primary cancers of the larynx, lung and thyroid presenting in one patient. Med J Malaysia; 2008 Dec;63(5):417-8
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  • Patients with multiple malignant primary tumours are often described, based on their chronology of presentation, as simultaneous, synchronous or metachronous tumours.
  • Lung malignancies presenting in association with head and neck tumours are well documented while there have been small series of thyroid synchronous cancers presenting with laryngeal lesions in literature.
  • We also discuss screening for lung and thyroid malignancies in patients with head and neck squamous cell carcinoma (SCC).
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Papillary / diagnosis. Carcinoma, Squamous Cell / diagnosis. Laryngeal Neoplasms / diagnosis. Lung Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Thyroid Neoplasms / diagnosis

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  • (PMID = 19803306.001).
  • [ISSN] 0300-5283
  • [Journal-full-title] The Medical journal of Malaysia
  • [ISO-abbreviation] Med. J. Malaysia
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Malaysia
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31. Munir N, Bradley PJ: Diagnosis and management of neoplastic lesions of the submandibular triangle. Oral Oncol; 2008 Mar;44(3):251-60
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  • [Title] Diagnosis and management of neoplastic lesions of the submandibular triangle.
  • Review of submandibular triangle neoplasms (benign and malignant) treated at a tertiary referral centre in the United Kingdom (1986-2004).
  • Forty nine benign and 58 malignant neoplasms of the submandibular triangle were reviewed.
  • Definitive diagnosis was by excision and pathological examination.
  • For malignant lesions (n=58), 48 were primary malignancies and 10 metastatic lesions.
  • The most frequent primary lesions were malignant non-Hodgkin lymphoma (n=22), adenoid cystic carcinoma (n=9) and mucoepidermoid carcinoma (n=9).
  • The mainstay treatment for both benign and malignant lesions was surgical either by extracapsular excision of the gland/lesion or selective levels I, IIa and III neck dissection.
  • There is a relatively high incidence of malignant neoplasms in this region (54%).
  • Malignant tumours have a poor symptomatology that can result in late (often post-operative) diagnosis.
  • The adequacy of primary surgery is crucial and would support the approach of a more radical excision primarily with a selective levels I, IIa and III neck dissection; ensuring a definitive operation for benign lesions, avoiding the risks of tumour spillage associated with a more limited excision; and removing the primary echelon of lymph nodes at risk of metastasis if the pathology in fact turns out to be malignant; without a significantly higher morbidity in comparison with an extracapsular gland/lesion excision.
  • [MeSH-major] Mouth Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / surgery. Child. Female. Humans. Lymphoma, Non-Hodgkin / diagnosis. Lymphoma, Non-Hodgkin / surgery. Male. Middle Aged. Retrospective Studies. Submandibular Gland Neoplasms / diagnosis. Submandibular Gland Neoplasms / surgery. Treatment Outcome

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  • (PMID = 17467329.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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32. Gupta G, Singh R, Shanmugasamy K, Kotasthane DS, Kotasthane VD: Basal cell adenocarcinoma in the tongue: an unusual presentation. Clin Med Insights Oncol; 2010 Nov 21;4:127-31
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  • [Title] Basal cell adenocarcinoma in the tongue: an unusual presentation.
  • We present a case of basal cell adenocarcinoma (BCAC) in the tongue in a 65-year old male.
  • The clinicopathological features and the cellular immunophenotype addressed the diagnosis towards BCAC of the tongue.
  • The goal of this report is to increase awareness of this rare disease and to review and discuss the differential diagnosis and important considerations in treatment.

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  • (PMID = 21151583.001).
  • [ISSN] 1179-5549
  • [Journal-full-title] Clinical Medicine Insights. Oncology
  • [ISO-abbreviation] Clin Med Insights Oncol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2999957
  • [Keywords] NOTNLM ; basal cell adenocarcinoma / minor salivary gland / tongue
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33. Reyes-Gibby CC, Shete S, Yennurajalingam S, Frazier M, Bruera E, Kurzrock R, Crane CH, Abbruzzese J, Evans D, Spitz MR: Genetic and nongenetic covariates of pain severity in patients with adenocarcinoma of the pancreas: assessing the influence of cytokine genes. J Pain Symptom Manage; 2009 Dec;38(6):894-902
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  • [Title] Genetic and nongenetic covariates of pain severity in patients with adenocarcinoma of the pancreas: assessing the influence of cytokine genes.
  • We evaluated a series of patients with histologically confirmed adenocarcinoma of the pancreas (n=484), who had completed a self-administered survey of pain before initiating any cancer treatment.

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  • (PMID = 19692203.001).
  • [ISSN] 1873-6513
  • [Journal-full-title] Journal of pain and symptom management
  • [ISO-abbreviation] J Pain Symptom Manage
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R03 CA128069; United States / NCI NIH HHS / CA / R03 CA128069-01A2; United States / NCI NIH HHS / CA / CA128069-01A2; United States / NCI NIH HHS / CA / K07 CA109043-05; United States / NCI NIH HHS / CA / CA109043-05; United States / NCI NIH HHS / CA / K07 CA109043; United States / NCI NIH HHS / CA / CA128069; United States / NCI NIH HHS / CA / P20 CA101936; United States / NCI NIH HHS / CA / CA101936; United States / NCI NIH HHS / CA / CA109043
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics; 0 / Cytokines
  • [Other-IDs] NLM/ NIHMS131146; NLM/ PMC2795073
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34. Moffatt-Bruce SD, Ross P, Leon ME, He G, Finkelstein SD, Vaida AM, Iwenofu OH, Frankel WL, Hitchcock CL: Comparative mutational profiling in the assessment of lung lesions: should it be the standard of care? Ann Thorac Surg; 2010 Aug;90(2):388-96
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  • We sought to review our experience in cases of two lung lesions or head and neck cancer and lung lesions to determine whether a significantly clinical problem existed, what standard processes were in place to address it, and whether a new diagnostic standard was required.
  • METHODS: Between January 1, 2007, and October 31, 2008, CMP was used in 24 cases of two lung lesions or a head and neck cancer and lung lesion.
  • The cases involved two lung lesions (n = 13) or a head and neck cancer and a lung lesion (n = 11).
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / genetics. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / genetics. Lung Neoplasms / diagnosis. Lung Neoplasms / genetics. Mutation
  • [MeSH-minor] Aged. Aged, 80 and over. DNA Fingerprinting. Diagnosis, Differential. Female. Head and Neck Neoplasms / pathology. Humans. Male. Middle Aged. Neoplasms, Multiple Primary / diagnosis. Retrospective Studies

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  • [Copyright] Copyright 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • [CommentIn] Ann Thorac Surg. 2010 Aug;90(2):397 [20667317.001]
  • (PMID = 20667316.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
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35. Park JC, Chae YK, Son CH, Kim MS, Lee J, Ostrow K, Sidransky D, Hoque MO, Moon C: Epigenetic silencing of human T (brachyury homologue) gene in non-small-cell lung cancer. Biochem Biophys Res Commun; 2008 Jan 11;365(2):221-6
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  • To discover novel tumor suppressor genes (TSGs) silenced by aberrant promoter methylation, we analyzed the gene expression profiles of two lung adenocarcinoma cell lines using pharmacologic-unmasking and subsequent microarray-analysis.
  • Aberrant methylation was detected in four genes (CRABP2, NOEY2, T, MAP2K3) in at least one lung adenocarcinoma cell lines.
  • Furthermore, the T promoter was methylated in 60% of primary lung adenocarcinomas versus 13% of non-malignant lung tissues.


36. Day TA, Beas RA, Schlosser RJ, Woodworth BA, Barredo J, Sharma AK, Gillespie MB: Management of paranasal sinus malignancy. Curr Treat Options Oncol; 2005 Jan;6(1):3-18
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  • Nevertheless, the majority of epithelial and salivary malignancies of this region (ie, squamous cell carcinoma, adenocarcinoma, adenoid cystic carcinoma, sinonasal undifferentiated carcinoma, and esthesioneuroblastoma) require surgical intervention as part of any treatment regimen.

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  • (PMID = 15610711.001).
  • [ISSN] 1527-2729
  • [Journal-full-title] Current treatment options in oncology
  • [ISO-abbreviation] Curr Treat Options Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 99
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37. Kim H, Ahn YC, Park HC, Lim DH, Nam H: Results and prognostic factors of hypofractionated stereotactic radiation therapy for primary or metastatic lung cancer. J Thorac Oncol; 2010 Apr;5(4):526-32
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  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / radiotherapy. Gastrointestinal Neoplasms / radiotherapy. Head and Neck Neoplasms / radiotherapy. Liver Neoplasms / radiotherapy. Lung Neoplasms / radiotherapy. Radiotherapy Planning, Computer-Assisted
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / radiotherapy. Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / radiotherapy. Dose Fractionation. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Staging. Radiotherapy Dosage. Retrospective Studies. Risk Factors. Survival Rate. Treatment Outcome


38. Stenner M, Weinell A, Ponert T, Hardt A, Hahn M, Preuss SF, Guntinas-Lichius O, Klussmann JP: Cytoplasmic expression of survivin is an independent predictor of poor prognosis in patients with salivary gland cancer. Histopathology; 2010 Nov;57(5):699-706
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  • The aim was to assess its expression and prognostic value in salivary gland adenocarcinoma and muco-epidermoid carcinoma.

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  • [Copyright] © 2010 Blackwell Publishing Limited.
  • (PMID = 21083600.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins
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39. Babin E, Rouleau V, Vedrine PO, Toussaint B, de Raucourt D, Malard O, Cosmidis A, Makaeieff M, Dehesdin D: Small cell neuroendocrine carcinoma of the nasal cavity and paranasal sinuses. J Laryngol Otol; 2006 Apr;120(4):289-97
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  • Immunohistochemistry proved useful for diagnosis in 20 cases.
  • One patient had an adenocarcinoma and an inverted papilloma associated with neuroendocrine carcinoma.
  • CONCLUSION: Small cell neuroendocrine carcinoma of the sinonasal tract is an uncommon neoplasm with aggressive clinical behaviour.
  • [MeSH-minor] Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / therapy. Retrospective Studies. Survival Rate

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  • (PMID = 16526967.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
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40. Nasir S, Aydin MA: Versatility of free SCIA/SIEA flaps in head and neck defects. Ann Plast Surg; 2010 Jul;65(1):32-7
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  • [Title] Versatility of free SCIA/SIEA flaps in head and neck defects.
  • Reconstruction of head and neck defects may require replacement of the bony structures, external soft tissue, and intraoral mucosa.
  • Recently, the authors used free superficial circumflex iliac artery/superficial inferior epigastric (SCIA/SIEA) flaps for head and neck reconstruction.
  • Fifteen patients underwent head and neck reconstruction with free SCIA/SIEA flaps (n = 16).
  • Based on our results, we believe that the free SCIA/SIEA flap is useful for soft tissue defect reconstruction in the head and neck.
  • (1) Large flap elevation is possible for reaching distant recipient vessels, (2) Two surgical teams may work at the same time preparing the donor and recipient regions, and (3) The flap design uses an abdominoplasty incision, which has minimal donor site morbidity.
  • [MeSH-minor] Adenocarcinoma / surgery. Adolescent. Adult. Aged. Bone Transplantation. Burns / surgery. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Child. Cicatrix / surgery. Facial Neoplasms / surgery. Female. Follow-Up Studies. Humans. Male. Maxilla / surgery. Maxillary Neoplasms / surgery. Middle Aged. Neck Injuries / surgery. Neoplasm Recurrence, Local / surgery. Reoperation. Scalp / surgery. Skin Neoplasms / surgery. Young Adult

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  • (PMID = 20574218.001).
  • [ISSN] 1536-3708
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] United States
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41. Hadler-Olsen E, Wetting HL, Rikardsen O, Steigen SE, Kanapathippillai P, Grénman R, Winberg JO, Svineng G, Uhlin-Hansen L: Stromal impact on tumor growth and lymphangiogenesis in human carcinoma xenografts. Virchows Arch; 2010 Dec;457(6):677-92
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  • Two oral and two skin SCC cell lines were used, as well as an endometrial adenocarcinoma cell line.

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  • (PMID = 20890764.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Serum Amyloid P-Component; 0 / Vascular Endothelial Growth Factor C
  • [Other-IDs] NLM/ PMC2995317
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42. Pujary K, Rangarajan S, Nayak DR, Balakrishnan R, Ramakrishnan V: Hyalinizing clear cell carcinoma of the base of tongue. Int J Oral Maxillofac Surg; 2008 Jan;37(1):93-6
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  • Hyalinizing clear cell carcinoma is a rare, low-grade neoplasm of the minor salivary glands.
  • The treatment of choice is wide excision and selective neck dissection, with or without radiotherapy.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Salivary Gland Neoplasms / pathology. Tongue Neoplasms / pathology

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  • (PMID = 17822882.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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43. Kämmerer PW, Kreft A, Toyoshima T, Al-Nawas B, Klein MO: Misleading initial histological diagnosis of a polymorphous low-grade adenocarcinoma in situ ex pleomorphic adenoma-a case report. Oral Maxillofac Surg; 2009 Jun;13(2):99-103
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  • [Title] Misleading initial histological diagnosis of a polymorphous low-grade adenocarcinoma in situ ex pleomorphic adenoma-a case report.
  • INTRODUCTION: Polymorphous low-grade adenocarcinoma (PLGA) are frequent tumours of palatinal minor salivary glands.
  • They appear clinically as solid mass located beneath intact surface epithelium, thus quite similar with benign neoplasm.
  • The correct aetiology of this disorder is still unknown.
  • Definitive histological examination of the whole tumour revealed a small malignant fraction of the specimen besides a major part of benign tissue formations (PA).
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Pleomorphic / pathology. Carcinoma in Situ / pathology. Neoplasms, Multiple Primary / pathology. Palatal Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy / methods. Diagnosis, Differential. Female. Humans. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • (PMID = 19189140.001).
  • [ISSN] 1865-1550
  • [Journal-full-title] Oral and maxillofacial surgery
  • [ISO-abbreviation] Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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44. Maceira Rozas Mdel C, Rey Liste T, García Caeiro AL, García Comesaña J: Recommendations for treatment with IMRT for prostate and head-neck cancer. Axencia de Avaliación de Tecnoloxías Sanitarias de Galicia. Clin Transl Oncol; 2006 Apr;8(4):262-5
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  • [Title] Recommendations for treatment with IMRT for prostate and head-neck cancer. Axencia de Avaliación de Tecnoloxías Sanitarias de Galicia.
  • In this article we present the basic standards for the IMRT treatment for prostate and head-neck cancer agreed upon a consensus meeting.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Head and Neck Neoplasms / radiotherapy. Prostatic Neoplasms / radiotherapy. Radiotherapy, Intensity-Modulated

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  • (PMID = 16648101.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Practice Guideline
  • [Publication-country] Italy
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45. Akinbami BO, Ugboko VI, Owotade EJ, Obiechina AE, Adetiloye VO, Ayoola O: Applications of ultrasonography in the diagnosis of soft tissue swellings of the cervicofacial region. West Afr J Med; 2006 Apr-Jun;25(2):110-8
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  • [Title] Applications of ultrasonography in the diagnosis of soft tissue swellings of the cervicofacial region.
  • PURPOSE: To determine the accuracy, sensitivity, specificity and prediction values of ultrasound as a means of diagnosis of cervico-facial soft tissue swellings.
  • The accuracy of ultrasound in the diagnosis of pleomorphic adenoma was 80% and 100% for both adenocarcinoma and hemangioma.
  • The sensitivity of ultrasound in the diagnosis of pleomorphic adenoma was 80% and 100% for adenocarcinoma, hemangioma, all the cysts and HIV associated swellings.
  • Ultrasound was also 100% specific in the diagnosis of monomorphic adenoma and hemangioma.
  • The accuracy of diagnosis is enhanced by the characteristics of the probe and the experience of the sonologist.
  • [MeSH-major] Head and Neck Neoplasms / ultrasonography. Soft Tissue Neoplasms / ultrasonography
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Cysts / ultrasonography. Diagnosis, Differential. Female. Hamartoma / ultrasonography. Humans. Infant. Infant, Newborn. Male. Middle Aged. Predictive Value of Tests. Sensitivity and Specificity

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  • (PMID = 16918181.001).
  • [ISSN] 0189-160X
  • [Journal-full-title] West African journal of medicine
  • [ISO-abbreviation] West Afr J Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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46. Kinoshita K, Kondo K, Watanabe K: [A case of advanced gastric cancer with distant lymph node metastases in cervical, supraclavicular and superior mediastinum successfully treated with S-1/Cisplatin (CDDP)/Lentinan combination chemotherapy]. Gan To Kagaku Ryoho; 2010 Apr;37(4):707-10
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  • Histopathological study showed poorly-differentiated adenocarcinoma in both stomach and supraclavicular lymph node.
  • However, gastric endoscopic biopsy still showed a remnant malignant lesion.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cisplatin / therapeutic use. Head / pathology. Lentinan / therapeutic use. Neck / pathology. Oxonic Acid / therapeutic use. Stomach Neoplasms / drug therapy. Tegafur / therapeutic use
  • [MeSH-minor] Aged. Drug Combinations. Female. Gastroscopy. Humans. Lymphatic Metastasis. Neoplasm Staging. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 20414031.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 37339-90-5 / Lentinan; 5VT6420TIG / Oxonic Acid; Q20Q21Q62J / Cisplatin
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47. Sidransky D: The oral cavity as a molecular mirror of lung carcinogenesis. Cancer Prev Res (Phila); 2008 Jun;1(1):12-4
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  • [Title] The oral cavity as a molecular mirror of lung carcinogenesis.

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  • [CommentOn] Cancer Prev Res (Phila). 2008 Jun;1(1):39-44 [19138934.001]
  • (PMID = 19138931.001).
  • [ISSN] 1940-6215
  • [Journal-full-title] Cancer prevention research (Philadelphia, Pa.)
  • [ISO-abbreviation] Cancer Prev Res (Phila)
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / 5U01 CA084986; United States / NIDCR NIH HHS / DE / P50 DE019032; United States / NIDCR NIH HHS / DE / R37 DE012588; United States / NIDCR NIH HHS / DE / R01 DE012588; United States / NCI NIH HHS / CA / U01 CA084986
  • [Publication-type] Comment; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS695561; NLM/ PMC4604561
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48. Tischoff I, Hengge UR, Vieth M, Ell C, Stolte M, Weber A, Schmidt WE, Tannapfel A: Methylation of SOCS-3 and SOCS-1 in the carcinogenesis of Barrett's adenocarcinoma. Gut; 2007 Aug;56(8):1047-53
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  • [Title] Methylation of SOCS-3 and SOCS-1 in the carcinogenesis of Barrett's adenocarcinoma.
  • BACKGROUND: The suppressors of cytokine signalling (SOCS) are inhibitors of cytokine signalling; methylation of SOCS-3 has been implicated in the tumorigenesis of liver as well as head and neck cancer.
  • AIMS: This study was performed to elucidate the role of SOCS-1 and SOCS-3 in Barrett's adenocarcinoma and its precursor lesions.
  • CONCLUSIONS: These data indicate that promoter methylation and subsequent transcript downregulation of SOCS-3 transcripts and, to a much lesser extent, SOCS-1 are involved in the multistep carcinogenesis of Barrett's adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / genetics. Barrett Esophagus / genetics. Esophageal Neoplasms / genetics. Suppressor of Cytokine Signaling Proteins / genetics
  • [MeSH-minor] Carcinoma in Situ / genetics. Carcinoma, Squamous Cell / genetics. Cell Line, Tumor. CpG Islands / genetics. DNA, Neoplasm / genetics. Humans. Methylation. Neoplasm Proteins / genetics. Promoter Regions, Genetic / genetics. Transcription, Genetic / genetics


49. Choussy O, Ferron C, Védrine PO, Toussaint B, Liétin B, Marandas P, Babin E, De Raucourt D, Reyt E, Cosmidis A, Makeieff M, Dehesdin D: Role of radiotherapy in the treatment of nasoethmoidal adenocarcinoma. Arch Otolaryngol Head Neck Surg; 2010 Feb;136(2):143-6
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  • [Title] Role of radiotherapy in the treatment of nasoethmoidal adenocarcinoma.
  • OBJECTIVE: To assess the efficacy of radiotherapy in the treatment of nasoethmoidal adenocarcinoma.
  • PATIENTS: The medical records of 418 patients who presented with nasoethmoidal adenocarcinoma from January 1, 1976, through December 31, 2001, were evaluated.
  • CONCLUSION: The results of this retrospective study suggest that radiotherapy can be used to treat nasoethmoidal adenocarcinoma, but its usefulness should be confirmed with further prospective studies.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Ethmoid Bone. Paranasal Sinus Neoplasms / radiotherapy. Skull Neoplasms / radiotherapy

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  • (PMID = 20157059.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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50. Combs SE, Konkel S, Schulz-Ertner D, Münter MW, Debus J, Huber PE, Thilmann C: Intensity modulated radiotherapy (IMRT) in patients with carcinomas of the paranasal sinuses: clinical benefit for complex shaped target volumes. Radiat Oncol; 2006;1:23
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  • Histological classification included squamous cell carcinoma in 6, adenocarcinoma in 8, adenoidcystic carcinoma in 20 and melanoma in 8 patients, respectively.
  • Six patients had been treated with RT during initial therapy after primary diagnosis, and IMRT was performed for the treatment of tumor progression as re-irradiation.
  • [MeSH-minor] Adenocarcinoma / mortality. Adenocarcinoma / radiotherapy. Carcinoma, Adenoid Cystic / mortality. Carcinoma, Adenoid Cystic / radiotherapy. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / radiotherapy. Female. Humans. Male. Melanoma / radiotherapy. Radiotherapy Dosage. Radiotherapy Planning, Computer-Assisted / methods. Treatment Outcome

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  • (PMID = 16859556.001).
  • [ISSN] 1748-717X
  • [Journal-full-title] Radiation oncology (London, England)
  • [ISO-abbreviation] Radiat Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1557519
  • [General-notes] NLM/ Original DateCompleted: 20070720
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51. Honings J, Gaissert HA, Verhagen AF, van Dijck JA, van der Heijden HF, van Die L, Bussink J, Kaanders JH, Marres HA: Undertreatment of tracheal carcinoma: multidisciplinary audit of epidemiologic data. Ann Surg Oncol; 2009 Feb;16(2):246-53
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  • An expert audit of primary tracheal carcinomas registered from 2000 to 2005 with the Netherlands Cancer Registry (NCR) included blinded patient data and radiographic review to assess diagnosis and resectability.
  • Of 101 NCR-registered primary tracheal carcinomas, the Radboud panel diagnosis was metastatic disease or local extension of adjacent tumors in 34.
  • A majority of cases meeting audit criteria for diagnosis and surgical resection was treated with other modalities.
  • The audit of a national cancer registry suggests that incorrect diagnosis and undertreatment are common in rare airway tumors.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / epidemiology. Adenocarcinoma / therapy. Adult. Aged. Aged, 80 and over. Carcinoma, Large Cell / diagnosis. Carcinoma, Large Cell / epidemiology. Carcinoma, Large Cell / therapy. Carcinoma, Small Cell / diagnosis. Carcinoma, Small Cell / epidemiology. Carcinoma, Small Cell / therapy. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / therapy. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / therapy. Neoplasm Staging. Netherlands / epidemiology

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  • (PMID = 19037701.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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52. Zheng M, Morgan-Lappe SE, Yang J, Bockbrader KM, Pamarthy D, Thomas D, Fesik SW, Sun Y: Growth inhibition and radiosensitization of glioblastoma and lung cancer cells by small interfering RNA silencing of tumor necrosis factor receptor-associated factor 2. Cancer Res; 2008 Sep 15;68(18):7570-8
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  • Moreover, siRNA silencing of TRAF2 in UM-SCC-1 head and neck cancer cells also conferred radiosensitization.
  • Further support for the role of TRAF2 in cancer comes from the observations that TRAF2 is overexpressed in both lung adenocarcinoma tissues and multiple lung cancer cell lines.

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  • (PMID = 18794145.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA118762-03; United States / NCI NIH HHS / CA / CA118762; United States / NCI NIH HHS / CA / CA116982; United States / NCI NIH HHS / CA / R21 CA116982-02; United States / NCI NIH HHS / CA / R21 CA116982; United States / NCI NIH HHS / CA / R01 CA118762; United States / NCI NIH HHS / CA / CA111554-04; United States / NCI NIH HHS / CA / R01 CA111554; United States / NCI NIH HHS / CA / CA116982-02; United States / NCI NIH HHS / CA / CA111554; United States / NCI NIH HHS / CA / R01 CA118762-03; United States / NCI NIH HHS / CA / R01 CA111554-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AGFG1 protein, human; 0 / Cell Cycle Proteins; 0 / I-kappa B Proteins; 0 / NF-kappa B; 0 / Nuclear Pore Complex Proteins; 0 / RNA, Small Interfering; 0 / RNA-Binding Proteins; 0 / TNF Receptor-Associated Factor 2; 139874-52-5 / NF-kappaB inhibitor alpha
  • [Other-IDs] NLM/ NIHMS70987; NLM/ PMC2597026
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53. Lavu H, Mascaro AA, Grenda DR, Sauter PK, Leiby BE, Croker SP, Witkiewicz A, Berger AC, Rosato EL, Kennedy EP, Yeo CJ: Margin positive pancreaticoduodenectomy is superior to palliative bypass in locally advanced pancreatic ductal adenocarcinoma. J Gastrointest Surg; 2009 Nov;13(11):1937-46; discussion 1946-7
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  • [Title] Margin positive pancreaticoduodenectomy is superior to palliative bypass in locally advanced pancreatic ductal adenocarcinoma.
  • BACKGROUND: Pancreatic ductal adenocarcinoma is an aggressive disease.
  • OBJECTIVE: The aim of this study was to determine if there is a difference in the perioperative outcomes and survival patterns between patients who undergo MP PD and those who undergo PB for locally advanced disease in the treatment of pancreatic ductal adenocarcinoma.
  • METHODS: We reviewed our pancreatic surgery database (January 2005-December 2007) to identify all patients who underwent exploration with curative intent of pancreatic ductal adenocarcinoma of the head/neck/uncinate process of the pancreas.
  • For the MP PD group, the distribution of positive margins on permanent section was 57% retroperitoneal soft tissue, 19% with more than one positive margin, 11% pancreatic neck, and 8% bile duct.

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  • (PMID = 19760308.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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54. Sargent R, LiVolsi V, Murphy J, Mantha G, Hunt JL: BRAF mutation is unusual in chronic lymphocytic thyroiditis-associated papillary thyroid carcinomas and absent in non-neoplastic nuclear atypia of thyroiditis. Endocr Pathol; 2006;17(3):235-41
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  • [MeSH-major] Adenocarcinoma, Papillary / genetics. Hashimoto Disease / genetics. Proto-Oncogene Proteins B-raf / genetics. Thyroid Neoplasms / genetics

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  • (PMID = 17308360.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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55. Warchoł R, Szymański L, Seichter A: [Rectal adenocarcinoma metastasis to the facial skin--case report]. Otolaryngol Pol; 2008;62(1):96-9
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  • [Title] [Rectal adenocarcinoma metastasis to the facial skin--case report].
  • In a very few cases its spread seems unpredictable and can cause a distant metastasis to head and neck region.
  • Histopatological examination of specimen from the facial skin lesion revealed adenocarcinoma cells.
  • RESULTS AND CONCLUSIONS: We present this case report as an example of an unusual and rare secondary malignancy of head and neck, emphasizing the interdisciplinary character of oncological treatment and the role of oncological vigilance on every step of diagnosis.
  • [MeSH-major] Adenocarcinoma / secondary. Facial Neoplasms / secondary. Rectal Neoplasms / pathology. Skin Neoplasms / secondary

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  • (PMID = 18637429.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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56. Heinroth S, Bilkenroth U, Eckert AW, Maurer P: [Bone metastases in the maxilla as first manifestation of renal cell cancer. A case report]. Mund Kiefer Gesichtschir; 2006 Jan;10(1):42-5
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  • The first histological and clinical diagnosis revealed a granuloma pyogenicum.
  • Diagnostic procedures detected an adenocarcinoma of the left kidney with pelvic metastases.
  • CONCLUSION: The present case report demonstrates how difficult it can be to provide the right pathological diagnosis in biopsy material even regarding obvious malignancy.
  • [MeSH-major] Carcinoma, Renal Cell / secondary. Kidney Neoplasms / diagnosis. Maxillary Neoplasms / secondary
  • [MeSH-minor] Biopsy, Fine-Needle. Bone Neoplasms / diagnosis. Bone Neoplasms / pathology. Bone Neoplasms / secondary. Bone Neoplasms / therapy. Combined Modality Therapy. Diagnosis, Differential. Disease Progression. Female. Humans. Kidney / pathology. Maxilla / pathology. Middle Aged. Pelvic Neoplasms / diagnosis. Pelvic Neoplasms / pathology. Pelvic Neoplasms / secondary. Pelvic Neoplasms / therapy

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  • (PMID = 16402238.001).
  • [ISSN] 1432-9417
  • [Journal-full-title] Mund-, Kiefer- und Gesichtschirurgie : MKG
  • [ISO-abbreviation] Mund Kiefer Gesichtschir
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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57. Tanaka K: A case of metastases to the paranasal sinus from rectal mucinous adenocarcinoma. Int J Clin Oncol; 2006 Feb;11(1):64-5
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  • [Title] A case of metastases to the paranasal sinus from rectal mucinous adenocarcinoma.
  • We report a case of metastases to the paranasal sinus from rectal adenocarcinoma.
  • A 72-year-old woman, who had a history of therapy with rectal adenocarcinoma, came to our hospital for visual loss in her right eye.
  • From the surgical specimen, we found that the tumor was a metastasis of a previously managed rectal mucinous adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Paranasal Sinus Neoplasms / secondary. Rectal Neoplasms / pathology

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  • (PMID = 16508732.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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58. Orvidas LJ, Lewis JE, Weaver AL, Bagniewski SM, Olsen KD: Adenocarcinoma of the nose and paranasal sinuses: a retrospective study of diagnosis, histologic characteristics, and outcomes in 24 patients. Head Neck; 2005 May;27(5):370-5
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  • [Title] Adenocarcinoma of the nose and paranasal sinuses: a retrospective study of diagnosis, histologic characteristics, and outcomes in 24 patients.
  • RESULTS: Twenty-four patients (17 men) with sinonasal adenocarcinoma were identified.
  • Nasal obstruction was the most common presenting symptom (75%), and the nose was the most common site of involvement (83%).
  • CONCLUSIONS: Presentation and treatment for nasal adenocarcinoma varies widely.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / mortality. Nose Neoplasms / diagnosis. Nose Neoplasms / mortality. Paranasal Sinus Neoplasms / diagnosis. Paranasal Sinus Neoplasms / mortality
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Brain Neoplasms / mortality. Brain Neoplasms / secondary. Epistaxis / etiology. Female. Humans. Male. Middle Aged. Minnesota / epidemiology. Nasal Obstruction / etiology. Neoplasm Recurrence, Local. Retrospective Studies. Survival Rate

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  • [Copyright] 2005 Wiley Periodicals, Inc.
  • (PMID = 15714475.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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59. Aird DW, Puttasiddaiah P, Berry S, Spyridakou C, Kumar M: Spatial orientation of the facial nerve in relation to parotid tumours. J Laryngol Otol; 2006 May;120(5):371-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / surgery. Facial Paralysis / etiology. Facial Paralysis / pathology. Female. Follow-Up Studies. Hodgkin Disease / pathology. Hodgkin Disease / surgery. Humans. Male. Middle Aged. Prospective Studies

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  • (PMID = 16696874.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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60. Gras-Cabrerizo JR, Montserrat-Gili JR, León-Vintró X, Massegur-Solench H, de Vega JM, Virós-Porcuna D: Treatment results for ethmoid sinus carcinoma. J Laryngol Otol; 2009 Oct;123(10):1120-4
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  • Two patients (6 per cent) had nodal metastasis at the time of diagnosis.
  • We do not recommend prophylactic neck treatment for ethmoid sinus carcinoma.
  • [MeSH-minor] Adenocarcinoma / radiotherapy. Adenocarcinoma / surgery. Adult. Aged. Aged, 80 and over. Alcohol Drinking / epidemiology. Carcinoma, Squamous Cell / radiotherapy. Carcinoma, Squamous Cell / surgery. Combined Modality Therapy / methods. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Retrospective Studies. Smoking / epidemiology. Treatment Outcome

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  • (PMID = 19646299.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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61. Breiting L, Christensen L, Dahlstrøm K, Breiting V, Winther JF: Primary mucinous carcinoma of the skin: a population-based study. Int J Dermatol; 2008 Mar;47(3):242-5
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  • BACKGROUND: Primary mucinous carcinoma of the skin (PMCS) is a rare malignant tumor deriving from the sweat glands.
  • It is typically located on the head and is often mistaken for a metastasis from a more common primary tumor of the breast or gastrointestinal tract.
  • Seven cases were found on the scalp or neck, five on the eyelids, two on the face, and one on the trunk.
  • [MeSH-major] Adenocarcinoma, Mucinous / epidemiology. Skin Neoplasms / epidemiology

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  • (PMID = 18289323.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Lavasani L, Zapanta PE, Tanna N, Sadeghi N: Metastasis of prostatic adenocarcinoma to the sphenoid sinus. Ann Otol Rhinol Laryngol; 2006 Sep;115(9):690-3
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  • [Title] Metastasis of prostatic adenocarcinoma to the sphenoid sinus.
  • The presentation, diagnosis, and management of prostatic adenocarcinoma metastatic to the sphenoid sinus are reviewed.
  • A 67-year-old man with a history of prostatic adenocarcinoma presented with gradual left visual loss.
  • Operative biopsy of the lesion was significant for adenocarcinoma of the prostate.
  • When an otolaryngologist encounters a mass in the sphenoid sinus, he or she needs to consider a diverse differential diagnosis.
  • As in this clinical scenario of a patient with a history of prostatic adenocarcinoma, appropriate analysis would entail sending specimens for immunohistochemical staining, such as prostate-specific antigen and prostate-specific acid phosphatase.
  • Correct diagnosis is crucial, as these patients may achieve remission and prolonged survival with irradiation and/or hormonal therapy.
  • [MeSH-major] Adenocarcinoma / pathology. Paranasal Sinus Neoplasms / secondary. Prostatic Neoplasms / pathology. Sphenoid Sinus / pathology

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  • (PMID = 17044541.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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63. Iezzi G, Piattelli A, Rubini C, Goteri G, Artese L, Perrotti V, Carinci F: Maspin expression in oral squamous cell carcinoma. J Craniofac Surg; 2007 Sep;18(5):1039-43
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  • A high expression of maspin was correlated with better rates of survival and absence of nodal metastases in head and neck squamous cell carcinoma.
  • In contrast, some studies have shown that maspin overexpression is correlated with a poor prognosis in pancreatic and ovarian cancers and in lung adenocarcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Mouth Neoplasms / metabolism. Neoplasm Proteins / metabolism. Serpins / metabolism


64. Lang BH, Lo CY, Chan WF, Lam AK, Wan KY: Classical and follicular variant of papillary thyroid carcinoma: a comparative study on clinicopathologic features and long-term outcome. World J Surg; 2006 May;30(5):752-8
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  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Thyroid Neoplasms / pathology. Thyroidectomy / mortality
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Lymph Node Excision. Male. Middle Aged. Neck. Neoplasm Recurrence, Local. Patient Selection. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 16680590.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
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65. Glynne-Jones R, Mawdsley S, Harrison M: Cetuximab and chemoradiation for rectal cancer--is the water getting muddy? Acta Oncol; 2010 Apr;49(3):278-86
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  • The epidermal growth factor receptor (EGFR) inhibitor cetuximab has been successfully combined with radical radiotherapy in head and neck cancer.
  • This review examines the clinical evidence and potential mechanisms for an interaction when EGFR inhibitors are added to fluoropyrimidine-based chemoradiation in rectal adenocarcinoma.
  • DISCUSSION: Potential reasons for the disappointing results of EGFR inhibition with fluoropyrimidine-based preoperative chemoradiation include a less critical role of repopulation in rectal adenocarcinoma using a non-curative radiation dose; or antagonistic effects on 5FU-based chemoradiation and oxaliplatin, if some cells arrest in G1 or G2-M and fail to pass through S phase.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / radiotherapy. Antibodies, Monoclonal / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Receptor, Epidermal Growth Factor / antagonists & inhibitors. Rectal Neoplasms / drug therapy. Rectal Neoplasms / radiotherapy

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  • (PMID = 20180626.001).
  • [ISSN] 1651-226X
  • [Journal-full-title] Acta oncologica (Stockholm, Sweden)
  • [ISO-abbreviation] Acta Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Organoplatinum Compounds; 0 / Quinazolines; 0 / panitumumab; 04ZR38536J / oxaliplatin; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; 7673326042 / irinotecan; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; PQX0D8J21J / Cetuximab; S65743JHBS / gefitinib; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin
  • [Number-of-references] 70
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66. Whitt JC, Schafer DR, Callihan MD: Multiple malignant salivary gland neoplasms: mucoepidermoid carcinoma of palate and adenoid cystic carcinoma of floor of mouth. Head Neck Pathol; 2008 Mar;2(1):41-8
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  • [Title] Multiple malignant salivary gland neoplasms: mucoepidermoid carcinoma of palate and adenoid cystic carcinoma of floor of mouth.
  • There are 31 acceptable cases of multiple malignant salivary gland neoplasms reported in the world literature.
  • Multiple malignant tumors of the same histologic type are more common than those of different histologic type.
  • Bilateral acinic cell adenocarcinoma was the most frequent combination of multiple salivary gland malignancy, accounting for 14 cases (10 synchronous and four metachronous).
  • Polymorphous low-grade adenocarcinoma accounted for three of the four cases of multiple malignant tumors involving minor salivary glands.
  • Individuals with a history of malignancy are at risk for the development of additional malignant tumors and should receive appropriate clinical follow-up.

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  • (PMID = 20614341.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2807610
  • [Keywords] NOTNLM ; Metachronous neoplasms / Multiple malignant salivary gland neoplasms / Salivary gland neoplasms / Salivary gland tumors / Synchronous neoplasms
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67. Liu JW, Nagpal JK, Sun W, Lee J, Kim MS, Ostrow KL, Zhou S, Jeronimo C, Henrique R, Van Criekinge W, Moon CS, Califano JA, Trink B, Sidransky D: ssDNA-binding protein 2 is frequently hypermethylated and suppresses cell growth in human prostate cancer. Clin Cancer Res; 2008 Jun 15;14(12):3754-60
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  • [Title] ssDNA-binding protein 2 is frequently hypermethylated and suppresses cell growth in human prostate cancer.
  • PURPOSE: Prostate cancer is a major cause of cancer death among men and the development of new biomarkers is important to augment current detection approaches.
  • EXPERIMENTAL DESIGN: We identified hypermethylation of the ssDNA-binding protein 2 (SSBP2) promoter as a potential DNA marker for human prostate cancer based on previous bioinformatics results and pharmacologic unmasking microarray.
  • We then did quantitative methylation-specific PCR in primary prostate cancer tissues to confirm hypermethylation of the SSBP2 promoter, and analyzed its correlation with clinicopathologic data.
  • We further examined SSBP2 expression in primary prostate cancer and studied its role in cell growth.
  • RESULTS: Quantitative methylation-specific PCR results showed that the SSBP2 promoter was hypermethylated in 54 of 88 (61.4%) primary prostate cancers versus 0 of 23 (0%) in benign prostatic hyperplasia using a cutoff value of 120.
  • Furthermore, we found that expression of SSBP2 was down-regulated in primary prostate cancers and cancer cell lines.
  • Hypermethylation of the SSBP2 promoter and its expression were closely associated with higher stages of prostate cancer.
  • Reactivation of SSBP2 expression by the demethylating agent 5-aza-2'-deoxycytidine in prostate cancer cell lines confirmed epigenetic inactivation as one major mechanism of SSBP2 regulation.
  • Moreover, forced expression of SSBP2 inhibited prostate cancer cell proliferation in the colony formation assay and caused cell cycle arrest.
  • CONCLUSION: SSBP2 inhibits prostate cancer cell proliferation and seems to represent a novel prostate cancer-specific DNA marker, especially in high stages of human prostate cancer.

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  • (PMID = 18559593.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA084986-10; United States / NCI NIH HHS / CA / U01 CA084986; United States / NCI NIH HHS / CA / U01 CA084986-10
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / SSBP2 protein, human; 776B62CQ27 / decitabine; M801H13NRU / Azacitidine
  • [Other-IDs] NLM/ NIHMS280870; NLM/ PMC3082869
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68. Resto VA, Chan AW, Deschler DG, Lin DT: Extent of surgery in the management of locally advanced sinonasal malignancies. Head Neck; 2008 Feb;30(2):222-9
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  • [MeSH-minor] Adenocarcinoma / mortality. Adenocarcinoma / radiotherapy. Adenocarcinoma / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / mortality. Carcinoma, Adenoid Cystic / radiotherapy. Carcinoma, Adenoid Cystic / surgery. Combined Modality Therapy. Disease-Free Survival. Esthesioneuroblastoma, Olfactory / mortality. Esthesioneuroblastoma, Olfactory / radiotherapy. Esthesioneuroblastoma, Olfactory / surgery. Female. Humans. Male. Middle Aged. Nasal Cavity. Sarcoma / mortality. Sarcoma / radiotherapy. Sarcoma / surgery

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  • (PMID = 17902164.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P01-CA-21239
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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69. Dutsch-Wicherek M, Popiela TJ, Klimek M, Rudnicka-Sosin L, Wicherek L, Oudinet JP, Skladzien J, Tomaszewska R: Metallothionein stroma reaction in tumor adjacent healthy tissue in head and neck squamous cell carcinoma and breast adenocarcinoma. Neuro Endocrinol Lett; 2005 Oct;26(5):567-74
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  • [Title] Metallothionein stroma reaction in tumor adjacent healthy tissue in head and neck squamous cell carcinoma and breast adenocarcinoma.
  • The aim of our study was to evaluate the MT expression in head and neck squamous cells carcinoma and breast adenocarcinoma and their histologically healthy adjacent tissue.
  • MATERIALS AND METHODS: We have sampled 29 tissue samples in total derived from head and neck cancers and 29 samples of their clear surgical margins, 33 breast adenocarcinomas and 33 clear surgical margins.
  • RESULTS: MT expression was revealed in 85,7% of head and neck cancers and 94% of breast adenocarcinomas.
  • MT expression was statistically significantly higher in tumor adjacent tissue than in cancer tissue in cases with the presence of lymph node metastases in both, breast adenocarcinoma and head and neck squamous cell carcinoma.
  • [MeSH-major] Adenocarcinoma / metabolism. Breast Neoplasms / metabolism. Carcinoma, Squamous Cell / metabolism. Head and Neck Neoplasms / metabolism. Metallothionein / metabolism

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  • (PMID = 16264399.001).
  • [ISSN] 0172-780X
  • [Journal-full-title] Neuro endocrinology letters
  • [ISO-abbreviation] Neuro Endocrinol. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Sweden
  • [Chemical-registry-number] 9038-94-2 / Metallothionein
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70. Kupferman ME, de la Garza GO, Santillan AA, Williams MD, Varghese BT, Huh W, Roberts D, Weber RS: Outcomes of pediatric patients with malignancies of the major salivary glands. Ann Surg Oncol; 2010 Dec;17(12):3301-7
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  • Patients less than 19 years of age with a diagnosis of a major salivary gland malignancy were identified at the M. D.
  • [MeSH-major] Adenocarcinoma / therapy. Carcinoma, Adenoid Cystic / therapy. Carcinoma, Mucoepidermoid / therapy. Carcinoma, Squamous Cell / therapy. Salivary Gland Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Child, Preschool. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Neoplasm Staging. Radiotherapy Dosage. Retrospective Studies. Survival Rate. Treatment Outcome. Young Adult

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  • (PMID = 20585877.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. Pietniczka-Załeska M, Dabrowska-Bień J: [Parotid tumors: a two-year experience of Otolaryngology Department at MSS Hospital in Warsaw]. Otolaryngol Pol; 2009 Sep;63(7):43-6
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  • THE AIM OF THE STUDY: Tumors of the salivary glands represent about 3% of head and neck neoplasms.
  • The aim of the study is to present current epidemiological data, most frequent complains, our surgical technique, histopathological diagnosis, complications rate and follow-up.
  • RESULTS: The frequency of incidence of benign tumours was 90% and the most frequent histopathological diagnosis was pleomorphic adenoma (49%) and adenolymphoma (42%).
  • By 6% of our patients malignant neoplasms were developed and tumours of non-neoplastic origin by 4% of theme.
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenocarcinoma / surgery. Parotid Neoplasms / epidemiology. Parotid Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Follow-Up Studies. Hospitals, Special. Humans. Male. Middle Aged. Neoplasm Staging. Oral Surgical Procedures / statistics & numerical data. Poland. Retrospective Studies. Survival Analysis. Treatment Outcome. Young Adult

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  • (PMID = 20564899.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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72. Ozmen MM, Zulfikaroglu B, Kucuk NO, Ozalp N, Aras G, Koseoglu T, Koç M: Lymphoscintigraphy in detection of the regional lymph node involvement in gastric cancer. Ann R Coll Surg Engl; 2006 Nov;88(7):632-8
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  • [MeSH-major] Adenocarcinoma / radionuclide imaging. Lymph Nodes / radionuclide imaging. Stomach Neoplasms / radionuclide imaging
  • [MeSH-minor] Adult. Aged. Female. Humans. Lymphatic Metastasis / diagnosis. Lymphatic Metastasis / radionuclide imaging. Male. Middle Aged. Sensitivity and Specificity. Tomography, X-Ray Computed

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  • (PMID = 17132310.001).
  • [ISSN] 1478-7083
  • [Journal-full-title] Annals of the Royal College of Surgeons of England
  • [ISO-abbreviation] Ann R Coll Surg Engl
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73. Sun M, Behrens C, Feng L, Ozburn N, Tang X, Yin G, Komaki R, Varella-Garcia M, Hong WK, Aldape KD, Wistuba II: HER family receptor abnormalities in lung cancer brain metastases and corresponding primary tumors. Clin Cancer Res; 2009 Aug 1;15(15):4829-37
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  • However, adenocarcinoma metastases (30%) showed higher frequency of EGFR amplification than corresponding primary tumors (10%).


74. Martínez JG, Pérez-Escuredo J, López F, Suárez C, Alvarez-Marcos C, Llorente JL, Hermsen MA: Microsatellite instability analysis of sinonasal carcinomas. Otolaryngol Head Neck Surg; 2009 Jan;140(1):55-60
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  • OBJECTIVES: Intestinal-type sinonasal adenocarcinoma (ITAC) and squamous cell carcinoma of the nasal cavity (SCCNC) are histopathologically but not etiologically similar to colorectal adenocarcinoma or to laryngeal squamous cell carcinoma, respectively.
  • CONCLUSION: MSI may be involved in squamous cell carcinoma, but not in adenocarcinoma of the nasal cavities.
  • [MeSH-major] Adenocarcinoma / genetics. Carcinoma, Squamous Cell / genetics. Microsatellite Instability. Nose Neoplasms / genetics

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  • (PMID = 19130962.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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75. Sarioglu S: Update on inverted epithelial lesions of the sinonasal and nasopharyngeal regions. Head Neck Pathol; 2007 Sep;1(1):44-9
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  • [MeSH-minor] Adenocarcinoma / diagnosis. Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / diagnosis. Diagnosis, Differential. Hamartoma / metabolism. Hamartoma / pathology. Humans. Inflammation / diagnosis. Keratins / metabolism. Polyps / diagnosis. Teratoma / diagnosis

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  • (PMID = 20614281.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Congresses
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
  • [Other-IDs] NLM/ PMC2807496
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76. Haro A, Yano T, Yoshida T, Ito K, Morodomi Y, Shoji F, Nakashima T, Maehara Y: Results of a surgical resection of pulmonary metastasis from malignant head and neck tumor. Interact Cardiovasc Thorac Surg; 2010 May;10(5):700-3
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  • [Title] Results of a surgical resection of pulmonary metastasis from malignant head and neck tumor.
  • There have been only a few reports about a surgical resection of pulmonary metastasis from malignant head and neck tumor.
  • We retrospectively reviewed 25 patients who underwent a pulmonary metastasectomy from malignant head and neck tumor at Kyushu University Hospital from 1981 through 2008.
  • To obtain a long survival, a positive surgical resection is considered to be an effective and standard treatment for pulmonary metastasis from malignant head and neck tumor.
  • It is also necessary, however, to elucidate fully the primary site and histology of such pulmonary metastasis.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Lung Neoplasms / secondary. Lung Neoplasms / surgery. Lymph Node Excision / methods. Lymph Nodes / pathology. Neoplasm Recurrence, Local / mortality
  • [MeSH-minor] Adenocarcinoma / mortality. Adenocarcinoma / secondary. Adenocarcinoma / surgery. Adolescent. Adult. Aged. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / surgery. Disease-Free Survival. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Staging. Pneumonectomy / methods. Pneumonectomy / mortality. Proportional Hazards Models. Retrospective Studies. Risk Assessment. Survival Analysis. Young Adult

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  • [Copyright] 2010 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.
  • (PMID = 20123888.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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77. Calabrese L, Jereczek-Fossa BA, Jassem J, Rocca A, Bruschini R, Orecchia R, Chiesa F: Diagnosis and management of neck metastases from an unknown primary. Acta Otorhinolaryngol Ital; 2005 Feb;25(1):2-12
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  • [Title] Diagnosis and management of neck metastases from an unknown primary.
  • Neck lymph node metastases from occult primary constitute about 5%-10% of all patients with carcinoma of unknown primary site.
  • Metastases in the upper and middle neck (levels I-II-III-V) are generally attributed to head and neck cancers, whereas the lower neck (level IV) involvement is often associated with primaries below the clavicles.
  • Diagnostic procedures include a careful clinical evaluation and a fiberoptic endoscopic examination of the head and neck mucosa, biopsies from all suspicious sites or blindly from the sites of possible origin of the primary, computerized tomography scan, and magnetic resonance.
  • The most frequent histological finding is Squamous Cell Carcinoma, particularly when the upper neck is involved.
  • In these cases, a systematic tonsillectomy in the absence of suspicious lesions is discussed since up to 25% of primary tumours can be detected in this site.
  • Thoracic, and abdominal primaries (especially from lung, oesophagus, stomach, ovary or pancreas) should be sought in the case of adenocarcinoma and involvement of the lower neck.
  • Therapeutic approaches include surgery (neck dissection), with or without post-operative radiotherapy, radiotherapy alone and radiotherapy followed by surgery as reported by several guide-lines.
  • In early stages (N1), neck dissection and radiotherapy seem to have similar efficacy, whereas more advanced cases (N2, N3) require combined approaches.
  • The extent of radiotherapy (irradiation of bilateral neck and mucosa versus ipsilateral neck radiotherapy) remains debatable.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / secondary. Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / secondary. Neoplasms, Unknown Primary
  • [MeSH-minor] Aged. Follow-Up Studies. Humans. Middle Aged. Neoplasm Staging

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  • (PMID = 16080309.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 102
  • [Other-IDs] NLM/ PMC2639847
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78. Wang J, Deng X, Jin X, Zhang C, Zhou J, Zhou Q, Liu J, Qian M: [Management of the sentinel lymph node of papillary thyroid carcinoma in surgery]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2007 Jun;21(12):543-4, 547
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  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Sentinel Lymph Node Biopsy. Thyroid Neoplasms / pathology

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  • (PMID = 17802825.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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79. Tomoda C, Uruno T, Takamura Y, Ito Y, Miya A, Kobayashi K, Matsuzuka F, Kuma K, Miyauchi A: Ultrasonography as a method of screening for tracheal invasion by papillary thyroid cancer. Surg Today; 2005;35(10):819-22
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  • [MeSH-major] Adenocarcinoma, Papillary / diagnostic imaging. Adenocarcinoma, Papillary / secondary. Thyroid Neoplasms / diagnostic imaging. Thyroid Neoplasms / surgery. Tracheal Neoplasms / diagnostic imaging. Tracheal Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Staging. Predictive Value of Tests. Preoperative Care / methods. Probability. Risk Assessment. Sensitivity and Specificity. Thyroidectomy / methods. Ultrasonography, Doppler


80. Mazeron JJ, European Society for Therapeutic Radiology and Oncology (ESTRO): [Minutes of the 23th meeting of the European Society for Therapeutic Radiology and Oncology (ESTRO). Amsterdam, 24-28 October 2004]. Cancer Radiother; 2005 Mar;9(2):122-6
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  • [Transliterated title] Compte rendu de la 23e réunion de l'European Society for Therapeutic Radiology and Oncology (ESTRO). Amsterdam, 24-28 octobre 2004.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / radiotherapy. Breast Neoplasms / radiotherapy. Head and Neck Neoplasms / radiotherapy. Prostatic Neoplasms / drug therapy. Prostatic Neoplasms / radiotherapy. Rectal Neoplasms / radiotherapy

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  • (PMID = 15820439.001).
  • [ISSN] 1278-3218
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0 / Radiation-Protective Agents; EC 3.4.21.77 / Prostate-Specific Antigen; M487QF2F4V / Amifostine; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil; YL5FZ2Y5U1 / Methotrexate; CMF protocol
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81. Douglas JG, Goodkin R, Laramore GE: Gamma knife stereotactic radiosurgery for salivary gland neoplasms with base of skull invasion following neutron radiotherapy. Head Neck; 2008 Apr;30(4):492-6
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  • The patients had the following characteristics: median age: 54 years (range, 23-80); median follow-up period: 20.5 months (range, 4-55); women-to-men patient ratio: 1.1:1; histology: 29 adenoid cystic, 3 adenocarcinoma, 1 acinic cell, 1 mucoepidermoid; primary sites of disease: 6 nasopharyngeal, 14 paranasal sinuses, 4 parotid gland, 8 oral cavity, 1 lacrimal gland, and 1 auditory canal.
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / radiotherapy. Adenocarcinoma / surgery. Adult. Aged. Aged, 80 and over. Case-Control Studies. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Radiotherapy Dosage. Skull Base / pathology. Skull Base / surgery. Treatment Outcome

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  • (PMID = 18023034.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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82. Behrens C, Feng L, Kadara H, Kim HJ, Lee JJ, Mehran R, Hong WK, Lotan R, Wistuba II: Expression of interleukin-1 receptor-associated kinase-1 in non-small cell lung carcinoma and preneoplastic lesions. Clin Cancer Res; 2010 Jan 1;16(1):34-44
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  • EXPERIMENTAL DESIGN: Archived tissue from NSCLC (adenocarcinoma and squamous cell carcinoma; n = 306) and adjacent bronchial epithelial specimens (n = 315) were analyzed for the immunohistochemical expression of IRAK-1, and the findings were correlated with patients' clinicopathologic features.
  • In adenocarcinoma, combined low level of expression of nuclear IRAK-1 and NF-kappaB correlated significantly with worse overall (HR, 2.485; P = 0.007) and recurrence-free (HR, 3.058; P = 0.006) survivals in stage I/II patients.

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  • (PMID = 20028769.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA070907-119004; United States / NCI NIH HHS / CA / P01 CA091844-020002; United States / NCI NIH HHS / CA / P01 CA091844; United States / NCI NIH HHS / CA / CA091844-020002; United States / NCI NIH HHS / CA / P01 CA091844-010002; United States / NCI NIH HHS / CA / P50 CA070907-119004; United States / NCI NIH HHS / CA / P50 CA070907; United States / NCI NIH HHS / CA / 1P01 CA91844-03; United States / NCI NIH HHS / CA / CA091844-010002
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Interleukin-1; 0 / NF-kappa B; EC 2.7.11.1 / Interleukin-1 Receptor-Associated Kinases
  • [Other-IDs] NLM/ NIHMS155236; NLM/ PMC2811365
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83. Luong A, Citardi MJ, Batra PS: Management of sinonasal malignant neoplasms: defining the role of endoscopy. Am J Rhinol Allergy; 2010 Mar-Apr;24(2):150-5
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  • [Title] Management of sinonasal malignant neoplasms: defining the role of endoscopy.
  • The five most common pathologies were squamous cell carcinoma (21), melanoma (10), esthesioneuroblastoma (8), adenocarcinoma (7), and sinonasal undifferentiated carcinoma (3).
  • CONCLUSION: The endoscope is a versatile tool for management of sinonasal malignant neoplasms.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Disease Progression. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Staging. Survival Analysis


84. Yu WB, Zhang NS, Zeng ZY: [Use of en bloc principle in re-operation of thyroid carcinoma]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2009 Apr;44(4):268-71
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  • There were, 10 in primary site, 8 in VI level, and 21 in both.
  • [MeSH-major] Adenocarcinoma, Papillary / surgery. Thyroid Neoplasms / surgery. Thyroidectomy / methods
  • [MeSH-minor] Adult. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm, Residual / surgery. Reoperation. Young Adult

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  • (PMID = 19558829.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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85. Zheng J, Chen Y, Zhang J: [Basal cell adenocarcinoma of nasal septum: a case report and review of literatures]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2009 Mar;23(5):209-10
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  • [Title] [Basal cell adenocarcinoma of nasal septum: a case report and review of literatures].
  • OBJECTIVE: To summarize clinical features, diagnosis, differential diagnosis, treatment and prognosis of basal cell adenocarcinoma.
  • METHOD: A retrospective study were subjected to one case with basal cell adenocarcinoma of the nasal septum, and the related literature were reviewed.
  • RESULT: Basal cell adenocarcinoma often occurred in the salivary glands and minor salivary glands of salivary palate and other parts.
  • CONCLUSION: Basal cell adenocarcinoma is rare seen in the salivary gland tumors.
  • [MeSH-major] Adenocarcinoma. Nasal Septum / pathology. Nose Neoplasms

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  • (PMID = 19522187.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] China
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86. Gelpke H, Grieder F, Decurtins M, Cadosch D: Recurrent laryngeal nerve monitoring during esophagectomy and mediastinal lymph node dissection. World J Surg; 2010 Oct;34(10):2379-82
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  • Diagnosis of postoperative RLN paralysis was performed using indirect laryngoscopy.
  • [MeSH-minor] Adenocarcinoma / surgery. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / surgery. Feasibility Studies. Female. Humans. Lung Neoplasms / surgery. Male. Mediastinum. Middle Aged. Monitoring, Intraoperative. Pneumonectomy / adverse effects. Prospective Studies. Recurrent Laryngeal Nerve / physiology

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  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
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87. Xiao GZ, Gao L: Central lymph node metastasis: is it a reliable indicator of lateral node involvement in papillary thyroid carcinoma? World J Surg; 2010 Feb;34(2):237-41
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  • METHODS: This retrospective study consists of 121 patients with PTC who underwent ipsilateral selective neck dissection.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Lymphatic Metastasis / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Analysis of Variance. Chi-Square Distribution. Child. Female. Humans. Male. Middle Aged. Neck Dissection. Predictive Value of Tests. Retrospective Studies. Sensitivity and Specificity. Statistics, Nonparametric. Thyroidectomy. Treatment Outcome. Ultrasonography

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  • [ISO-abbreviation] World J Surg
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  • [Publication-type] Journal Article
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88. Azzali G: Tumor cell transendothelial passage in the absorbing lymphatic vessel of transgenic adenocarcinoma mouse prostate. Am J Pathol; 2007 Jan;170(1):334-46
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  • [Title] Tumor cell transendothelial passage in the absorbing lymphatic vessel of transgenic adenocarcinoma mouse prostate.
  • The distribution and fine structure of the tumor-associated absorbing lymphatic vessel in the tumor mass of prostate adenocarcinoma and of seminal vesicle metastasis in transgenic mice was studied for the purpose of understanding the modality of tumor cell transendothelial passage from the extravasal matrix into the lymphatic vessel.
  • [MeSH-major] Adenocarcinoma / pathology. Cell Movement. Lymphatic Metastasis / pathology. Prostatic Neoplasms / pathology

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  • (PMID = 17200205.001).
  • [ISSN] 0002-9440
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Polyomavirus Transforming
  • [Other-IDs] NLM/ PMC1762681
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89. Wilkins T, Gillies RA: Office-based unsedated ultrathin esophagoscopy in a primary care setting. Ann Fam Med; 2005 Mar-Apr;3(2):126-30
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  • PURPOSE: Gastroesophageal reflux disease is common and with time may be complicated by Barrett's esophagus and esophageal adenocarcinoma.

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  • (PMID = 15798038.001).
  • [ISSN] 1544-1717
  • [Journal-full-title] Annals of family medicine
  • [ISO-abbreviation] Ann Fam Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1466858
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90. Du Y, Li Z, Li L, Chen ZG, Sun SY, Chen P, Shin DM, Khuri FR, Fu H: Distinct growth factor-induced dynamic mass redistribution (DMR) profiles for monitoring oncogenic signaling pathways in various cancer cells. J Recept Signal Transduct Res; 2009;29(3-4):182-94
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  • In response to EGF, squamous cell carcinoma of the head and neck cells exhibited a rapid rise in DMR signal, whereas lung adenocarcinoma cells showed a biphasic DMR profile, suggesting a cell type-dependent DMR response.
  • The defined DMR signatures offer a simple yet sensitive tool for evaluating EGFR-targeted agents, as shown with gefitinib and erlotinib.

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  • (PMID = 19604037.001).
  • [ISSN] 1532-4281
  • [Journal-full-title] Journal of receptor and signal transduction research
  • [ISO-abbreviation] J. Recept. Signal Transduct. Res.
  • [Language] eng
  • [Grant] United States / NHGRI NIH HHS / HG / U54 HG003918; United States / NCI NIH HHS / CA / 5 P50 CA128613; United States / NCI NIH HHS / CA / P01 CA116676-04; United States / NHGRI NIH HHS / HG / 5U54 HG003918; United States / NHGRI NIH HHS / HG / U54 HG003918-03; United States / NCI NIH HHS / CA / P01 CA116676; United States / NCI NIH HHS / CA / T32 CA160040; United States / NCI NIH HHS / CA / P50 CA128613-03; United States / NCI NIH HHS / CA / P50 CA128613
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Protein Kinase Inhibitors; 0 / Quinazolines; 62229-50-9 / Epidermal Growth Factor; DA87705X9K / Erlotinib Hydrochloride; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; S65743JHBS / gefitinib
  • [Other-IDs] NLM/ NIHMS142951; NLM/ PMC3746742
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91. Katkoori VR, Jia X, Chatla C, Kumar S, Ponnazhagan S, Callens T, Messiaen L, Grizzle WE, Manne U: Clinical significance of a novel single nucleotide polymorphism in the 5' untranslated region of the Rabphillin-3A-Like gene in colorectal adenocarcinoma. Front Biosci; 2008 Jan 01;13:1050-61
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  • [Title] Clinical significance of a novel single nucleotide polymorphism in the 5' untranslated region of the Rabphillin-3A-Like gene in colorectal adenocarcinoma.
  • The recently identified human ortholog of the Rabphillin-3A-Like (RPH3AL) gene, located at the 17p13.3 locus, has been assessed for its mutational status and clinical significance in colorectal adenocarcinoma (CRC).