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1. de la Cruz J, Hidalgo LA, Feliu J, Admella C, Muns R, del Bas M, Suñol X: [Gallbladder adenocarcinoma: tumoral staging, histological prognostic factors and survival]. Cir Esp; 2005 Jan;77(1):18-21
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  • [Title] [Gallbladder adenocarcinoma: tumoral staging, histological prognostic factors and survival].
  • [Transliterated title] Adenocarcinoma de vesícula biliar: estadio tumoral, factores pronósticos histológicos y supervivencia.
  • INTRODUCTION: Gallbladder adenocarcinoma is an aggressive tumor and is one of the digestive tract malignancies with the poorest prognosis.
  • Because of loco-regional extension and delayed diagnosis, curative resection is often impossible.
  • To determine histological prognostic factors and survival in relation to tumoral stage at diagnosis, we performed a retrospective study of our patients with gallbladder carcinoma.
  • PATIENTS AND METHOD: Sixty-two patients with gallbladder adenocarcinoma diagnosed over a 15-year period were retrospectively included in this study.
  • CONCLUSIONS: Preoperative diagnosis of gallbladder adenocarcinoma is difficult except in advanced cases.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / pathology. Gallbladder Neoplasms / mortality. Gallbladder Neoplasms / pathology

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  • (PMID = 16420877.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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2. Hori T, Wagata T, Takemoto K, Shigeta T, Takuwa H, Hata K, Uemoto S, Yokoo N: Spontaneous necrosis of solid gallbladder adenocarcinoma accompanied with pancreaticobiliary maljunction. World J Gastroenterol; 2008 Oct 14;14(38):5933-7
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  • [Title] Spontaneous necrosis of solid gallbladder adenocarcinoma accompanied with pancreaticobiliary maljunction.
  • A 71-year-old Japanese man with acute cholecystitis and an incarcerated gallbladder (GB) stone was admitted.
  • We were agonized in making the qualitative diagnosis of mass-like lesions of the fundus, such as a benign tumor, cancer, or debris.
  • Amylase levels in the common bile duct and gallbladder were quite high.
  • Although this necrotic nodule included non-viable adenocarcinoma cells, viable cancer cell nests were located in the muscularis propria and subcutaneous layer.
  • Histopathological examination confirmed a solid adenocarcinoma.
  • Thus, we diagnosed it as a gallbladder cancer, based on histopathological analysis of the resected specimen.
  • Histopathological findings revealed no cancer, hyperplasia or dysplasia in the additionally resected specimens.
  • We present the first case of spontaneous necrosis of solid gallbladder adenocarcinoma, with a review of previous studies.
  • [MeSH-major] Adenocarcinoma / pathology. Biliary Tract / abnormalities. Gallbladder Neoplasms / pathology. Incidental Findings. Pancreas / abnormalities

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  • (PMID = 18855999.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 25
  • [Other-IDs] NLM/ PMC2751910
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3. Shimizu T, Tajiri T, Akimaru K, Arima Y, Yoshida H, Yokomuro S, Mamada Y, Taniai N, Mizuguchi Y, Kawahigashi Y, Naito Z: Combined neuroendocrine cell carcinoma and adenocarcinoma of the gallbladder: report of a case. J Nippon Med Sch; 2006 Apr;73(2):101-5
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  • [Title] Combined neuroendocrine cell carcinoma and adenocarcinoma of the gallbladder: report of a case.
  • Abdominal computed tomography confirmed thickening of the gallbladder wall and a 15 x 8 cm mass occupying almost all of the right lobe and medial segment of the liver.
  • With a preoperative diagnosis of malignant gallbladder tumor infiltrating the liver, right hepatic trisegmentectomy was performed.
  • Near this small cell proliferation was a focus of tubular adenocarcinoma that showed a zone of transition from the small cell neuroendocrine pattern.
  • The patient was diagnosed with neuroendocrine cell carcinoma combined with adenocarcinoma of the gallbladder.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Neuroendocrine / pathology. Gallbladder Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 16641536.001).
  • [ISSN] 1345-4676
  • [Journal-full-title] Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
  • [ISO-abbreviation] J Nippon Med Sch
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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4. Galvão FH, Pestana JO, Capelozzi VL: Fatal gemcitabine-induced pulmonary toxicity in metastatic gallbladder adenocarcinoma. Cancer Chemother Pharmacol; 2010 Feb;65(3):607-10
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  • [Title] Fatal gemcitabine-induced pulmonary toxicity in metastatic gallbladder adenocarcinoma.
  • In this report, we describe a fatal gemcitabine-induced pulmonary toxicity in a patient with gallbladder metastatic adenocarcinoma.
  • A 72-year-old patient was submitted to an elective laparoscopic cholecystectomy, and a tubular adenocarcinoma in the gallbladder was incidentally diagnosed.
  • The colonic lesion was conveniently removed and the histology evaluation confirmed the diagnosis of adenocarcinoma tubular.
  • [MeSH-major] Adenocarcinoma / drug therapy. Deoxycytidine / analogs & derivatives. Gallbladder Neoplasms / drug therapy. Lung Diseases, Interstitial / chemically induced

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  • (PMID = 19904536.001).
  • [ISSN] 1432-0843
  • [Journal-full-title] Cancer chemotherapy and pharmacology
  • [ISO-abbreviation] Cancer Chemother. Pharmacol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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5. Garg PK, Khurana N, Hadke NS: Subcutaneous and breast metastasis from asymptomatic gallbladder carcinoma. Hepatobiliary Pancreat Dis Int; 2009 Apr;8(2):209-11
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  • [Title] Subcutaneous and breast metastasis from asymptomatic gallbladder carcinoma.
  • BACKGROUND: Though gallbladder carcinoma is associated with early lymphatic and hematogenous spread, the only common extra-abdominal site of metastasis is lung.
  • Gallbladder carcinoma metastasizing to breast and subcutaneous tissue is not known.
  • METHOD: This report describes an interesting and unusual case of asymptomatic gallbladder carcinoma presenting with subcutaneous and breast metastasis.
  • Fine needle aspiration cytology (FNAC) of these nodules revealed metastatic adenocarcinoma.
  • An ultrasound of the abdomen followed by a contrast-enhanced CT scan showed a growth in gallbladder, infiltrating the liver with multiple hepatic metastases.
  • CT-guided FNAC from the growth in the gallbladder revealed adenocarcinoma.
  • She was diagnosed as a case of metastatic adenocarcinoma of the gallbladder and palliative combination chemotherapy with gemcitabine and carboplatin was given.
  • She died within three weeks of diagnosis due to hepatic encephalopathy.
  • CONCLUSIONS: This report highlights an unusual metastasis of gallbladder carcinoma to the breast and subcutaneous tissue presenting as multiple lesions, which has never been reported in the English literature.
  • These were unknown sites of metastasis for carcinoma of the gallbladder.
  • [MeSH-minor] Adult. Female. Gallbladder Neoplasms / pathology. Humans

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  • (PMID = 19357037.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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6. Okada K, Kijima H, Imaizumi T, Hirabayashi K, Matsuyama M, Yazawa N, Oida Y, Dowaki S, Tobita K, Ohtani Y, Tanaka M, Inokuchi S, Makuuchi H: Wall-invasion pattern correlates with survival of patients with gallbladder adenocarcinoma. Anticancer Res; 2009 Feb;29(2):685-91
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  • [Title] Wall-invasion pattern correlates with survival of patients with gallbladder adenocarcinoma.
  • Gallbladder carcinomas (GBC) frequently show vascular invasion and metastasis when the carcinoma cells invade the perimuscular connective tissue (pT2 according to the TNM classification) through the muscular layer.
  • Sixty-six surgically resected gallbladder adenocarcinomas invading the perimuscular connective tissue (pT2) and beyond the gallbladder wall, including the visceral serosa, (pT3/pT4) were examined.
  • In conclusion, the DG invasion pattern is an indicator of high malignant potential and indirectly worsens the prognosis of patients with gallbladder adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Gallbladder Neoplasms / pathology

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  • (PMID = 19331223.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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7. Hara S, Kijima H, Okada K, Igarashi Y: Invasive micropapillary variant of the gallbladder adenocarcinoma and its aggressive potential for lymph node metastasis. Biomed Res; 2010 Apr;31(2):89-95
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  • [Title] Invasive micropapillary variant of the gallbladder adenocarcinoma and its aggressive potential for lymph node metastasis.
  • An invasive micropapillary variant (IMPV) has recently been described in several organs but has not been reported in the gallbladder.
  • We analyzed the clinicopathologic findings of IMPV and compared them with those of a conventional adenocarcinoma in the gallbladder to clarify the highly aggressive potential of IMPV of gallbladder carcinoma.
  • Ninety consecutive cases of surgically resected gallbladder carcinomas were studied for age, gender, type, depth of invasion and lymph node and distant metastases.
  • Histologically, IMPV of gallbladder carcinoma was characterized by a small cluster of tumor cells lying within clear stromal spaces.
  • IMPV is a useful predictor of regional lymph node metastasis in gallbladder adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma / pathology. Gallbladder Neoplasms / pathology. Lymph Nodes / pathology

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  • (PMID = 20460736.001).
  • [ISSN] 1880-313X
  • [Journal-full-title] Biomedical research (Tokyo, Japan)
  • [ISO-abbreviation] Biomed. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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8. de la Parra-Márquez ML, Martínez-Garza H, Sánchez-Antúnez D, Cabañas-López A, Ramírez-Garza M, González-Quintanilla A: [Adenocarcinoma of the gallbladder as a histopathological finding after cholecystectomy]. Cir Cir; 2005 Mar-Apr;73(2):97-100
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  • [Title] [Adenocarcinoma of the gallbladder as a histopathological finding after cholecystectomy].
  • [Transliterated title] Adenocarcinoma de vesícula biliar como hallazgo histopatológico posterior a colecistecomía.
  • OBJECTIVE: We wanted to determine the incidence in our population of gallbladder adenocarcinoma based on a histopathologic study done after cholecystectomy in patients with a diagnosis of gallstones.
  • Finally, we calculated the incidence of malignant neoplasias of gallbladder in our hospital.
  • RESULTS: The most common histopathologic finding was cholesterolosis (incidence: 26%), followed by xanthogranulomatous gallbladder (incidence: 0.94%).
  • The incidence of gallbladder cancer was 0.54% (25 cases), the most common type being adenocarcinoma (incidence: 0.48%).
  • CONCLUSIONS: The incidence of gallbladder cancer in our hospital is among the lowest limits compared with the literature worldwide.
  • [MeSH-major] Adenocarcinoma / epidemiology. Gallbladder Neoplasms / epidemiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cholecystectomy. Cholecystectomy, Laparoscopic. Female. Gallbladder / pathology. Gallstones / surgery. Humans. Incidence. Male. Middle Aged. Retrospective Studies

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  • (PMID = 15910701.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Mexico
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9. Triolo O, Antico F, Mancuso A, Salimbeni V, Nicotina PA: Postmenopausal bleeding and vaginal nodules as the first presenting sign of adenocarcinoma of the gallbladder. Eur J Gynaecol Oncol; 2005;26(5):543-4
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  • [Title] Postmenopausal bleeding and vaginal nodules as the first presenting sign of adenocarcinoma of the gallbladder.
  • On biopsy, light microscopy suggested that the lesions might be metastatic foci from an extragenital cancer, with a prevalent tubular growth pattern.
  • Subsequently, high serum levels of such tumor marker were also found, and an extragenital cancer was suspected of pancreatic or biliary origin.
  • A mass in the gallbladder fossa was then detected by computed tomography and a primary gallbladder adenocarcinoma was confirmed on ultrasound-guided biopsy.
  • [MeSH-major] Adenocarcinoma / diagnosis. Gallbladder Neoplasms / diagnosis. Uterine Neoplasms / diagnosis. Vaginal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Fatal Outcome. Female. Humans. Neoplasm Metastasis. Postmenopause. Uterine Hemorrhage / etiology

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  • (PMID = 16285575.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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10. Chicos SC, Beznea A, Chebac GR, Ceauşu M, Ceauşu M: [The Krukenberg tumor caused by an adenocarcinoma of the gallbladder]. Chirurgia (Bucur); 2007 Jul-Aug;102(4):481-5
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  • [Title] [The Krukenberg tumor caused by an adenocarcinoma of the gallbladder].
  • This work presents the case of a 62 year-old woman's Krukenberg tumor caused by an adenocarcinoma of the gallbladder.
  • This was the presumptive diagnosis that was confirmed during the operation.
  • The characteristic feature of this case consists of the rarity of the Krukenberg tumors caused by a cancer of the gallbladder, the paraneoplastic pleurisy and the presence of the cells with "a ring with a seal" in the pleural liquid and in the ascites liquid.
  • The paraclinical investigations (echography, computerised tomography) were not able to specify the diagnosis before the operation.
  • [MeSH-major] Adenocarcinoma / secondary. Gallbladder Neoplasms / pathology. Krukenberg Tumor / secondary. Ovarian Neoplasms / secondary

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  • (PMID = 17966948.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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11. Wang YK, Zhao W, Hao Y, Zhang Y, Guo YB, Meng NL, Ma L, Li J: [Clinicopathologic features of gallbladder adenocarcinoma with marked stromal fibrosis--a report of 19 cases]. Ai Zheng; 2006 Jul;25(7):896-900
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  • [Title] [Clinicopathologic features of gallbladder adenocarcinoma with marked stromal fibrosis--a report of 19 cases].
  • BACKGROUND & OBJECTIVE: Macropathologic types of gallbladder cancer are mostly polyp type, intumescent type, and cauliflower form lump.
  • Its histological types include well or poorly differentiated adenocarcinoma, mucinous adenocarcinoma, and undifferentiated cancer.
  • This research was to explore the clinicopathologic features of gallbladder adenocarcinoma with marked stromal fibrosis.
  • METHODS: Pathology of 19 cases of gallbladder adenocarcinoma with marked stromal fibrosis was observed using a light microscopy and SP immunohistochemistry.
  • RESULTS: Most of the patients had long-term history of cholecystitis gallbladder calculus.
  • B ultrasound showed that the gallbladder wall was irregularly thickened or presented nodosity.
  • Observed with naked eyes, gallbladder adenocarcinoma with marked stromal fibrosis did not form cancer nodule and extrude into the gallbladder lumen, the gallbladder wall showed regional thickening, a few cases showed diffuse irregular thickening.
  • Observed under a light microscope, the adenocarcinoma cells were mostly arranged as single layers, seldom arranged as multiple layers, and formed adenoid structures with different sizes, various shapes, and irregular arrangement; the nuclei were heterogenic with haryomitosis presented in a few cases; inflammatory cells were infiltrated in hyperplastic fibrous connective tissue of some cases.
  • CONCLUSIONS: The clinical manifestation, macropathologic type, histological characteristics of gallbladder adenocarcinoma with stromal fibrosis are different from other types of adenocarcinoma.
  • Its genesis may be related to chronic cholecystitis: long-term inflammation causes regional hyperplasia and heterogeneity of the gland body, lead to focal or regional thickening of the gallbladder wall, and result in gallbladder adenocarcinoma with stromal fibrosis finally.
  • [MeSH-major] Adenocarcinoma / pathology. Gallbladder / pathology. Gallbladder Neoplasms / pathology. Keratins / metabolism
  • [MeSH-minor] Adult. Aged. Cholecystectomy. Diagnosis, Differential. Female. Fibrosis. Follow-Up Studies. Humans. Immunohistochemistry. Immunophenotyping. Male. Middle Aged

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  • (PMID = 16831286.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 68238-35-7 / Keratins
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12. Turrini R, Lanzani G, Salmi A: [Gallbladder adenoma with focal adenocarcinoma: a case report]. Recenti Prog Med; 2007 Oct;98(10):506-8
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  • [Title] [Gallbladder adenoma with focal adenocarcinoma: a case report].
  • [Transliterated title] Adenoma con focale adenocarcinoma della colecisti: descrizione di un caso.
  • Gallbladder polyps represent a frequent and asymptomatic finding on abdominal sonography.
  • We describe the ultrasound features of an asymptomatic 13-mm gallbladder polyp in a 29-year-old male.
  • To our knowledge, this is the first report of a gallbladder polyp already presenting severe dysplasia in a young Caucasian male without risk factors.
  • [MeSH-major] Adenoma / diagnosis. Cholecystectomy, Laparoscopic. Gallbladder Neoplasms / diagnosis. Polyps / complications
  • [MeSH-minor] Adult. Cholecystitis / complications. Cholecystitis / diagnosis. Cholecystitis / surgery. Chronic Disease. Humans. Male. Video-Assisted Surgery

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  • (PMID = 17970176.001).
  • [ISSN] 0034-1193
  • [Journal-full-title] Recenti progressi in medicina
  • [ISO-abbreviation] Recenti Prog Med
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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13. Liu DC, Yang ZL, Jiang S: Identification of musashi-1 and ALDH1 as carcinogenesis, progression, and poor-prognosis related biomarkers for gallbladder adenocarcinoma. Cancer Biomark; 2010-2011;8(3):113-21
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  • [Title] Identification of musashi-1 and ALDH1 as carcinogenesis, progression, and poor-prognosis related biomarkers for gallbladder adenocarcinoma.
  • In this study, we investigated the expressions of Msi-1 and ALDH1 in gallbladder adenocarcinoma (n=100), peritumoral tissues (n=46), adenomatous polyp (n=15), and chronic cholecystitis (n=35) using immunohistochemical method.
  • The percentage of cases with positive Msi-1 and ALDH1 expression were significantly higher in gallbladder adenocarcinoma than that in peritumoral tissues, adenomatous polyp and chronic cholecystitis (ps < 0.01).
  • The expression of Msi-1 and ALDH1 was significantly associated with differentiation, tumor mass, lymph node metastasis and invasion of adenocarcinoma.
  • The expression of Msi-1 and ALDH1 was found to be highly consistent in gallbladder adenocarcinoma (p < 0.01).
  • Multivariate Cox regression analysis showed that positive expression of Msi-1 or ALDH1 (p=0.016, p=0.006, respectively) was an independent bad-prognostic predictor in gallbladder adenocarcinoma.
  • Our study suggested that Msi-1 and/or ALDH1 expression might be closely related to the carcinogenesis, progression, clinical biological behaviors, and prognosis of gallbladder adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / physiopathology. Biomarkers, Tumor / analysis. Gallbladder Neoplasms / physiopathology. Isoenzymes / analysis. Nerve Tissue Proteins / analysis. RNA-Binding Proteins / analysis. Retinal Dehydrogenase / analysis
  • [MeSH-minor] Adenomatous Polyps / metabolism. Adult. Aged. Cholecystitis / metabolism. Disease Progression. Female. Gallbladder / chemistry. Gallbladder / pathology. Humans. Immunohistochemistry. Lymphatic Metastasis. Male. Middle Aged. Prognosis

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  • (PMID = 22012766.001).
  • [ISSN] 1875-8592
  • [Journal-full-title] Cancer biomarkers : section A of Disease markers
  • [ISO-abbreviation] Cancer Biomark
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Isoenzymes; 0 / MSI1 protein, human; 0 / Nerve Tissue Proteins; 0 / RNA-Binding Proteins; EC 1.2.1.- / aldehyde dehydrogenase 1; EC 1.2.1.36 / Retinal Dehydrogenase
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14. Jiang WX, Song BG, Tang RY, Fang JP: [Expression of nm23 and KAI1 and their clinical significance in gallbladder adenocarcinoma]. Zhonghua Zhong Liu Za Zhi; 2008 Jun;30(6):441-3
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  • [Title] [Expression of nm23 and KAI1 and their clinical significance in gallbladder adenocarcinoma].
  • OBJECTIVE: To investigate the expression of two tumor metastasis suppressor genes nm23 and KAI1 in gallbladder adenocarcinoma, and their clinicopathological significance.
  • METHODS: Specimens and clinical data from 31 gallbladder adenocarcinoma patients were collected.
  • CONCLUSION: The expressions of nm23 and KAI1 proteins are negatively correlated with clinical stage, but positively with histopathological grade in gallbladder adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / metabolism. Antigens, CD82 / metabolism. Gallbladder Neoplasms / metabolism. NM23 Nucleoside Diphosphate Kinases / metabolism

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  • (PMID = 19024519.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD82; 0 / NM23 Nucleoside Diphosphate Kinases; EC 2.7.4.6 / NME1 protein, human
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15. D'Angelica M, Dalal KM, DeMatteo RP, Fong Y, Blumgart LH, Jarnagin WR: Analysis of the extent of resection for adenocarcinoma of the gallbladder. Ann Surg Oncol; 2009 Apr;16(4):806-16
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  • [Title] Analysis of the extent of resection for adenocarcinoma of the gallbladder.
  • Gallbladder cancer has historically been considered an incurable malignancy; although, extended resection has been associated with cure in selected patients.
  • The objective of this study was to analyze the impact of the extent of resection for gallbladder adenocarcinoma on disease-specific survival (DSS) and perioperative morbidity.
  • Analysis of a prospective hepatobiliary surgery database identified patients undergoing surgical resection for gallbladder adenocarcinoma from 1990 to 2002.
  • We conclude that tumor biology and stage, rather than extent of resection, predict outcome after resection for gallbladder cancer.
  • [MeSH-major] Adenocarcinoma / surgery. Bile Duct Neoplasms / surgery. Gallbladder Neoplasms / surgery. Liver Neoplasms / surgery

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  • [CommentIn] Ann Surg Oncol. 2009 Aug;16(8):2084-5 [19506960.001]
  • [CommentIn] Ann Surg Oncol. 2009 Apr;16(4):787-8 [19165545.001]
  • (PMID = 18985272.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Martínez-Román S, Frumovitz M, Deavers MT, Ramirez PT: Metastatic carcinoma of the gallbladder mimicking an advanced cervical carcinoma. Gynecol Oncol; 2005 Jun;97(3):942-5
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  • [Title] Metastatic carcinoma of the gallbladder mimicking an advanced cervical carcinoma.
  • To our knowledge, only three cases of primary carcinoma of the gallbladder with metastasis to the cervix have been previously reported.
  • We report a case of metastatic gallbladder carcinoma mimicking a stage IIIB cervical carcinoma.
  • A Pap smear revealed adenocarcinoma, and a biopsy of the endocervical canal was consistent with poorly differentiated adenocarcinoma.
  • A chest CT revealed multiple lesions in both lungs suggestive of metastatic disease, and an abdominal CT revealed a gallbladder tumor with extension into the liver.
  • The patient underwent a CT-guided biopsy of one of the lung lesions and the pathologic findings were consistent with metastatic adenocarcinoma.
  • The patient was diagnosed with stage IVB primary gallbladder adenocarcinoma and was treated with capecitabine, but her condition deteriorated rapidly and she died 5 months later.
  • CONCLUSION: In patients with an atypical presentation for cervical adenocarcinoma, it is important to consider a metastatic tumor in the differential diagnosis and to perform a thorough work-up for metastatic disease before initiating therapy.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Gallbladder Neoplasms / diagnosis. Gallbladder Neoplasms / pathology. Uterine Cervical Neoplasms / diagnosis. Uterine Cervical Neoplasms / secondary
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans


17. Zhang L, Han F, Huang CS, Pang C, Han YZ, Hua YW: [Analysis of the treatment of unexpected gallbladder cancer]. Zhonghua Wai Ke Za Zhi; 2005 Apr 1;43(7):460-2
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  • [Title] [Analysis of the treatment of unexpected gallbladder cancer].
  • OBJECTIVE: To investigate the secondary operation methods and the effects on the prognosis of unexpected gallbladder cancer (UGC).
  • The 41 patients had undergone gallbladder excision because of cholecystitis complicated lithiasis of gallbladder (32 cases), polypi of gallbladder or adenoma (9 cases).
  • Postoperative pathology showed that 32 cases were adenocarcinoma of gallbladder, 6 cases were squamous carcinoma, 3 cases were squamous adenocarcinoma.
  • The second operation chose the improved method of Glenn excision of carcinoma of gallbladder.
  • RESULTS: On the second operation, 14 cases were with lymphatic metastasis, 14 with gallbladder metastasis, 6 with bile duct metastasis, 2 with pancreas metastasis.
  • [MeSH-major] Cholecystectomy / methods. Gallbladder Neoplasms / diagnosis. Gallbladder Neoplasms / surgery

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  • (PMID = 15854374.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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18. Pavić I, Marusić Z, Mijić A, Balicević D, Kruslin B, Tomas D: A case of signet-ring cell carcinoma of the gallbladder: immunohistochemistry and differential diagnosis. Acta Clin Croat; 2010 Jun;49(2):159-62
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  • [Title] A case of signet-ring cell carcinoma of the gallbladder: immunohistochemistry and differential diagnosis.
  • The morphological spectrum of gallbladder carcinoma is broad and variable.
  • Most of these tumors are tubular adenocarcinomas.
  • One of such tumors is the signet-ring cell carcinoma, which is a highly aggressive, mucin producing variant of gallbladder adenocarcinoma predominantly or exclusively composed of signet-ring cells.
  • We found only three cases of signet-ring cell carcinoma of the gallbladder previously reported.
  • We present the case of an 86-year-old woman with signet-ring cell carcinoma of the gallbladder and discuss the potential diagnostic dilemmas
  • [MeSH-major] Carcinoma, Signet Ring Cell / diagnosis. Gallbladder Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Humans. Immunohistochemistry

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  • (PMID = 21086733.001).
  • [ISSN] 0353-9466
  • [Journal-full-title] Acta clinica Croatica
  • [ISO-abbreviation] Acta Clin Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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19. van den Bos IC, Hussain SM, Dwarkasing RS, Stoop H, Zondervan PE, Krestin GP, de Man RA: Hepatoid adenocarcinoma of the gallbladder: a mimicker of hepatocellular carcinoma. Br J Radiol; 2007 Dec;80(960):e317-20
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  • [Title] Hepatoid adenocarcinoma of the gallbladder: a mimicker of hepatocellular carcinoma.
  • We present a case of a large gallbladder tumour in a patient with no known liver disease and elevated alpha-fetoprotein (AFP), in whom a differential diagnosis from hepatocellular carcinoma (HCC) in a non-cirrhotic liver was particularly difficult given the combination of the size of the tumour, solitary nature, elevated AFP and striking resemblance with HCC at histology.
  • In presenting this patient, we would like to emphasise the role of MRI as a problem-solving tool for analysis of rare tumours of non-hepatocellular origin, including hepatoid adenocarcinoma of the gallbladder.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Hepatocellular / diagnosis. Gallbladder Neoplasms / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Middle Aged

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  • (PMID = 18065642.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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20. von Meyenfeldt EM, Mantel SF, Gouma DJ, van Gulik TM: [Tumors in the gallbladder: a possible differentiation between malignant and benign tumours]. Ned Tijdschr Geneeskd; 2007 May 12;151(19):1049-54
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  • [Title] [Tumors in the gallbladder: a possible differentiation between malignant and benign tumours].
  • [Transliterated title] Tumoren in de galblaas; een moeilijke differentiatie tussen maligniteit en goedaardige tumor.
  • In a 59-year-old woman with pain in the right upper abdomen, echography and CT-scan revealed adenomatosis of the gallbladder.
  • In a 46-year-old man with fever and weight loss, echography revealed two polyps in the gallbladder.
  • In a 63-year-old man with systemic symptoms, a biopsy of the echographically diagnosed tumour of the gallbladder revealed that he had actually had cholecystitis.
  • Following cholecystectomy, an adenocarcinoma of the gallbladder was found.
  • Patients with a tumour in the gallbladder are often diagnosed with gallbladder cancer, which has a poor prognosis.
  • [MeSH-major] Cholecystectomy / methods. Gallbladder Diseases / diagnosis. Gallbladder Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Polyps / diagnosis. Polyps / surgery. Tomography, X-Ray Computed / methods. Ultrasonography / methods

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  • [CommentIn] Ned Tijdschr Geneeskd. 2007 Jul 21;151(29):1653; author reply 1653 [17727189.001]
  • [CommentIn] Ned Tijdschr Geneeskd. 2007 Jul 21;151(29):1652-3; author reply 1653 [17729454.001]
  • [CommentOn] Ned Tijdschr Geneeskd. 2007 May 12;151(19):1083-6 [17552418.001]
  • (PMID = 17552411.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; Comment; English Abstract; Journal Article
  • [Publication-country] Netherlands
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21. Olivas Mendoza G, Mesina Sandoval J, Mata Orozco VM, Hernández M: [Complicated pregnancy with lithiasis and resectable gallbladder cancer. A case report and literature review]. Ginecol Obstet Mex; 2005 Dec;73(12):661-5
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  • [Title] [Complicated pregnancy with lithiasis and resectable gallbladder cancer. A case report and literature review].
  • [Transliterated title] Embarazo con litiasis y cáncer vesicular resecable. Comunicación de un caso clínico y revisión bibliográfica.
  • Pregnancy complicated with gallbladder disease stone has an incidence of 2-14%, and more than 30% of patients do not respond to medical treatment; therefore, in order to reduce the morbidity and mortality in fetus and mother, surgical management would be required.
  • The current use of ultrasound of high resolution has facilitated the diagnosis and also, in the present clinical case, this imaging modality allowed us to suspect the unusual diagnosis reported, that corresponds to a female of 34 years old with 33 weeks of pregnancy, complicated with symptomatic gallbladder disease stone, whose pain was intractable at the expectant management.
  • The clinical diagnosis was corroborated by ultrasound and the report was: lithiasis, biliary sludge and an intragallbladder image of bilobular polypoid.
  • The patient was submitted to cholecystectomy by laparotomy, whose histopathologic findings were: cholelithiasis and in situ gallbladder adenocarcinoma with an exophytic growing variety.
  • [MeSH-major] Adenocarcinoma. Adenomatous Polyps. Carcinoma in Situ. Cholelithiasis. Gallbladder Neoplasms. Pregnancy Complications. Pregnancy Complications, Neoplastic


22. Tayo JR, Al-Abdulkarim H, Al-Rayess M: Brain metastasis as an initial manifestation of a gallbladder carcinoma. Neurosciences (Riyadh); 2005 Jul;10(3):235-7

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  • [Title] Brain metastasis as an initial manifestation of a gallbladder carcinoma.
  • Though autopsy studies demonstrated 5% metastasis to the brain, clinical presentation of a central nervous system metastasis from gallbladder cancer is rare.
  • We report a case of a 72-year-old woman who initially presented with a solitary brain metastasis from an adenocarcinoma of the gallbladder, which was diagnosed pre-operatively as glioblastoma multiforme.
  • We emphasize the importance of including metastasis in the differential diagnosis of single intracranial tumor for proper planning of patient management.

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  • (PMID = 22473267.001).
  • [ISSN] 1319-6138
  • [Journal-full-title] Neurosciences (Riyadh, Saudi Arabia)
  • [ISO-abbreviation] Neurosciences (Riyadh)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
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23. Zaydfudim V, Feurer ID, Wright JK, Pinson CW: The impact of tumor extent (T stage) and lymph node involvement (N stage) on survival after surgical resection for gallbladder adenocarcinoma. HPB (Oxford); 2008;10(6):420-7
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  • [Title] The impact of tumor extent (T stage) and lymph node involvement (N stage) on survival after surgical resection for gallbladder adenocarcinoma.
  • INTRODUCTION: Tumor extent (T stage) and lymph node involvement (N stage) have a known combined negative effect on survival in patients with gallbladder adenocarcinoma, but the independent effects of these factors have been less well described.
  • We investigated whether T stage and N stage independently predict survival after surgery for gallbladder adenocarcinoma.
  • METHODS: We queried the Surveillance, Epidemiology and End Results database for patients treated with surgical resection for gallbladder adenocarcinoma between 1988 and 2004.
  • CONCLUSIONS: Tumor extent and lymph node metastases are independent predictors of survival after surgical resection for gallbladder adenocarcinoma.
  • Tumor penetration of the gallbladder wall and pathologically confirmed lymph node involvement each carry poor prognosis.

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  • (PMID = 19088928.001).
  • [ISSN] 1365-182X
  • [Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association
  • [ISO-abbreviation] HPB (Oxford)
  • [Language] ENG
  • [Grant] United States / AHRQ HHS / HS / T32 HS013833
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2597319
  • [Keywords] NOTNLM ; SEER registry / gallbladder cancer / lymph node metastases / survival / tumor extent
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24. Kitajima K, Kobayashi S, Shiba H, Uwagawa T, Ishida Y, Aiba K, Kawakami M, Yanaga K: Successful treatment of advanced gallbladder cancer with an anticancer drug S-1: assessment based on intratumoral gene. Int J Clin Oncol; 2008 Dec;13(6):545-51
Hazardous Substances Data Bank. FLUOROURACIL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Successful treatment of advanced gallbladder cancer with an anticancer drug S-1: assessment based on intratumoral gene.
  • While surgical resection is the most effective treatment for gallbladder cancer, most of these cancers are not resectable at the time of diagnosis, and therefore, chemotherapy serves as the primary therapy in many cases.
  • However, to date, there is no standard chemotherapy for this cancer.
  • We report a case of advanced gallbladder cancer for which the anticancer drug S-1 was effective.
  • On workup, all abdominal images revealed the presence of advanced gallbladder cancer that had invaded the liver.
  • Because the gallbladder formed a relatively hard and swollen mass involving the omentum, as revealed during exploration, the surgical resection of the gallbladder was not possible at that time, and only hysterectomy and bilateral salpingo-oophorectomy were performed.
  • Pathologically, the tumor was diagnosed as an adenocarcinoma of the gallbladder, and no evidence of liver invasion was found.
  • Intratumoral gene expression analysis of the resected gallbladder revealed significantly elevated DPD expression.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Dihydrouracil Dehydrogenase (NADP) / genetics. Gallbladder Neoplasms / drug therapy. Gallbladder Neoplasms / genetics. Oxonic Acid / therapeutic use. Tegafur / therapeutic use

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  • (PMID = 19093184.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; EC 1.3.1.2 / Dihydrouracil Dehydrogenase (NADP); U3P01618RT / Fluorouracil
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25. Sakellaridis T, Mathioulakis S, Antiochos C: Synchronous early primary adenocarcinoma of both rectum and gallbladder. Report of a case. Int Semin Surg Oncol; 2005 Sep 14;2:19

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronous early primary adenocarcinoma of both rectum and gallbladder. Report of a case.
  • BACKGROUND: Synchronous early primary cancers are rare and in addition synchronous adenocarcinoma of both rectum and gallbladder is extremely rare.
  • CASE REPORT: We report an unusual case of synchronous early primary adenocarcinoma of rectum and gallbladder.
  • An endoscopy revealed adenocarcinoma of the lower rectum.
  • The histopathological diagnosis was well to middle differentiate adenocarcinoma of the gallbladder (T2, N0, M0; stage II) and middle differentiate adenocarcinoma of the rectum (T2, N0, M0; stage II).
  • CONCLUSION: For the cases of extracolonic primary cancer associated with colorectal primary carcinoma, Warren and Gates' diagnostic criteria are used.

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  • (PMID = 16162293.001).
  • [ISSN] 1477-7800
  • [Journal-full-title] International seminars in surgical oncology : ISSO
  • [ISO-abbreviation] Int Semin Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1236954
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26. del Pozo AC, De Battista S, Velasco D, Pianzola H, Rodríguez J: [Epidermoid carcinoma of gallbladder: analysis of our casuistic]. Acta Gastroenterol Latinoam; 2005;35(3):162-4
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  • [Title] [Epidermoid carcinoma of gallbladder: analysis of our casuistic].
  • [Transliterated title] Carcinoma epidermoide de vesícula: análisis de nuestra casuística.
  • BACKGROUND: The most common type of gallbladder cancer is the adenocarcinoma.
  • The squamous cell carcinoma represents only a 0-12% of all gallbladder tumors.
  • METHODS: 124 cases of malignant neoplasias of the gallbladder were diagnosed during the last 33 years in the Department of Surgery of our hospital.
  • Liver involvement was observed in 4 of 5 patients at the moment of diagnosis.
  • CONCLUSION: The tumor extention at the time of diagnosis is generally advanced and the outcome is not promising in this kind of gallbladder cancer.
  • [MeSH-major] Carcinoma, Squamous Cell. Gallbladder Neoplasms

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  • (PMID = 16333974.001).
  • [ISSN] 0300-9033
  • [Journal-full-title] Acta gastroenterologica Latinoamericana
  • [ISO-abbreviation] Acta Gastroenterol. Latinoam.
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Argentina
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27. Akatsu T, Aiura K, Shimazu M, Ueda M, Wakabayashi G, Tanabe M, Kawachi S, Kitajima M: Can endoscopic ultrasonography differentiate nonneoplastic from neoplastic gallbladder polyps? Dig Dis Sci; 2006 Feb;51(2):416-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Can endoscopic ultrasonography differentiate nonneoplastic from neoplastic gallbladder polyps?
  • The present study aimed to clarify the endoscopic ultrasonography (EUS) features of nonneoplastic (cholesterol polyps and adenomyomatosis) and neoplastic (adenoma and adenocarcinoma) gallbladder polyps and to evaluate the effectiveness and limitation of EUS in the differential diagnosis of these lesions.
  • We retrospectively compared EUS images with histologic findings in 29 surgical cases with gallbladder polyps with a diameter of 10 to 20 mm.
  • However, three of nine neoplastic lesions (three adenomas and six adenocarcinomas) showed one of these signs due to concomitant cholesterosis (n = 2) or proliferated Rokitansky-Aschoff sinuses (n = 1).
  • In conclusion, 69% (20/29) of gallbladder polyps larger than 10 mm that were preoperatively suspected of malignancy were nonneoplastic.
  • [MeSH-major] Adenocarcinoma / ultrasonography. Adenoma / ultrasonography. Endosonography. Gallbladder Diseases / ultrasonography. Gallbladder Neoplasms / ultrasonography. Polyps / ultrasonography
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 16534690.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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28. Orts JA, Morell L, Camps J, Traba ML, Belenguer A, Guerrero A: [Multiple enterolithiasis, coexisting with bladder and gallbladder lithiasis, associated with colon adenocarcinoma]. An Med Interna; 2005 May;22(5):227-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Multiple enterolithiasis, coexisting with bladder and gallbladder lithiasis, associated with colon adenocarcinoma].
  • [Transliterated title] Enterolitiasis múltiple, coexistiendo con litiasis biliar y vesical, asociada a adenocarcinoma de colon.
  • We report a case of multiple enterolithiasis, very infrequent pathology, coexisting with bladder and gall bladder lithiasis in a patient with colon adenocarcinoma.
  • Diagnosis was made by X-rays and CT images.
  • No risk factors for lithogenesis were found in this patient excluding the intestinal stasis caused by intestinal narrowing as a result of adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / complications. Calculi / complications. Cholelithiasis / complications. Colonic Neoplasms / complications. Intestinal Diseases / complications. Urinary Bladder Calculi / complications

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  • (PMID = 16001938.001).
  • [ISSN] 0212-7199
  • [Journal-full-title] Anales de medicina interna (Madrid, Spain : 1984)
  • [ISO-abbreviation] An Med Interna
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 27YLU75U4W / Phosphorus; I38ZP9992A / Magnesium; SY7Q814VUP / Calcium
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29. Yoshimitsu K, Irie H, Aibe H, Tajima T, Nishie A, Asayama Y, Matake K, Yamaguchi K, Matsuura S, Honda H: Well-differentiated adenocarcinoma of the gallbladder with intratumoral cystic components due to abundant mucin production: a mimicker of adenomyomatosis. Eur Radiol; 2005 Feb;15(2):229-33
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  • [Title] Well-differentiated adenocarcinoma of the gallbladder with intratumoral cystic components due to abundant mucin production: a mimicker of adenomyomatosis.
  • The prevalence and etiology of the cystic components within gallbladder carcinomas as seen on MR images were evaluated.
  • A retrospective review of MR images was performed for 35 proven gallbladder carcinomas in search of radiologically detectable intratumoral cystic components.
  • Three cases out of 35 proven gallbladder carcinomas were found to have intratumoral cystic components.
  • They were all well-differentiated adenocarcinomas, and the cystic components consisted of dilated neoplastic glands filled with abundant mucin pool.
  • Although rare, radiologists need to be aware that well-differentiated gallbladder carcinoma with mucin production can have cystic components, which may mimic adenomyomatosis.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Gallbladder Neoplasms / pathology. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Adenomyoma / pathology. Adult. Aged. Diagnosis, Differential. Female. Humans. Japan / epidemiology. Male. Middle Aged. Prevalence. Retrospective Studies. Statistics, Nonparametric

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  • [Cites] Radiology. 2003 Apr;227(1):80-8 [12601186.001]
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  • (PMID = 15662477.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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30. Sai JK, Suyama M, Kubokawa Y: A case of gallbladder carcinoma associated with pancreatobiliary reflux in the absence of a pancreaticobiliary maljunction: A hint for early diagnosis of gallbladder carcinoma. World J Gastroenterol; 2006 Jul 28;12(28):4593-5
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  • [Title] A case of gallbladder carcinoma associated with pancreatobiliary reflux in the absence of a pancreaticobiliary maljunction: A hint for early diagnosis of gallbladder carcinoma.
  • A 62-year-old man with progressive thickening of the gallbladder wall visited our outpatient clinic.
  • The biliary amylase level in the common bile duct was 19,900 IU/L and that of the gallbladder was 127,000 IU/L, although endoscopic retrograde cholangiopancreatography revealed no pancreaticobiliary maljunction.
  • Histology demonstrated a moderately differentiated adenocarcinoma of the gallbladder.
  • Pancreatobiliary reflux and associated gallbladder carcinoma were confirmed in the present case, in the absence of a pancreaticobiliary maljunction.
  • Earlier detection of the pancreatobiliary reflux and progressive thickening of the gallbladder wall might have led to an earlier resection of the gallbladder and improved this patient's poor prognosis.
  • [MeSH-major] Adenocarcinoma / complications. Bile Reflux / etiology. Common Bile Duct / physiopathology. Gallbladder Neoplasms / complications. Pancreas / physiopathology
  • [MeSH-minor] Amylases / analysis. Cholangiopancreatography, Endoscopic Retrograde. Gallbladder / enzymology. Gallbladder / pathology. Gallbladder / physiopathology. Humans. Male. Middle Aged. Prognosis

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  • [Cites] Gastroenterology. 1985 Dec;89(6):1258-65 [4054518.001]
  • [Cites] Am J Gastroenterol. 1987 Jan;82(1):20-4 [3799576.001]
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  • [Cites] Am J Gastroenterol. 1996 May;91(5):1007-11 [8633539.001]
  • (PMID = 16874881.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] EC 3.2.1.- / Amylases
  • [Other-IDs] NLM/ PMC4125656
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31. Itoh T, Fuji N, Taniguchi H, Yasukawa S, Yasuda H, Wakabayashi N, Watanabe T, Kosuga T, Kashimoto K, Yanagisawa A, Naito K: Double cancer of the cystic duct and gallbladder associated with low junction of the cystic duct. J Hepatobiliary Pancreat Surg; 2008;15(3):338-43
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Double cancer of the cystic duct and gallbladder associated with low junction of the cystic duct.
  • We report a case of double cancer of the cystic duct and gallbladder associated with low junction of the cystic duct.
  • Endoscopic retrograde cholangiography showed a stenotic lesion in the lower common bile duct and no visualization of the cystic duct or gallbladder.
  • A diagnosis of cancer arising from the cystic duct that entered the lower part of the common hepatic duct was made by intraductal ultrasonography, which showed an intraluminal protruding lesion in the cystic duct.
  • Isolated gallbladder cancer was also diagnosed, by abdominal computed tomography.
  • Histological examination revealed moderately differentiated adenocarcinoma of the cystic duct and well-differentiated adenocarcinoma of the gallbladder.
  • Double cancer of the cystic duct and gallbladder is extremely rare, and this case also suggests a relationship between a low junction of the cystic duct and neoplasm in the biliary tract.
  • [MeSH-major] Adenocarcinoma / pathology. Bile Duct Neoplasms / pathology. Cystic Duct. Gallbladder Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 18535776.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 19
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32. Tanaka S, Kubota D, Lee SH, Oba K, Yamamoto T, Ikebe T, Kubo S, Matsuyama M: Latent gallbladder carcinoma in a young adult patient with acute cholecystitis: report of a case. Surg Today; 2007;37(8):713-5
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Latent gallbladder carcinoma in a young adult patient with acute cholecystitis: report of a case.
  • Acute cholecystitis associated with gallbladder carcinoma is very rare in young patients (younger than 30 years of age).
  • Moreover, a definitive preoperative diagnosis is difficult.
  • Computed tomography and ultrasonography demonstrated an enlarged gallbladder with a diffuse thick wall and a 2-cm gallstone obstructing the cystic duct.
  • The preoperative diagnosis of gallstone-induced acute cholecystitis was made and an open cholecystectomy was thus performed 2 days after admission.
  • The macroscopic findings showed a necrotic enlarged gallbladder with a thick wall and a gallstone, but no intraluminal nodular lesion.
  • Histologic examinations revealed well-differentiated focal adenocarcinoma in the gallbladder mucosa, but no venous, lymphatic, or perineural invasion.
  • [MeSH-major] Cholecystitis, Acute / complications. Gallbladder Neoplasms / surgery. Gallstones / complications

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  • (PMID = 17643222.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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33. Sato K, Imai T, Shirota Y, Ueda Y, Katsuda S: Combined large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder. Pathol Res Pract; 2010 Jun 15;206(6):397-400
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combined large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder.
  • There are six previous reports on LCNEC in the gallbladder, comprising three cases combined with another tumor and three pure LCNECs.
  • We describe a tumor combined with LCNEC and adenocarcinoma elements arising in the gallbladder and give a review of the literature.
  • A 68-year-old woman was diagnosed as having gallbladder wall thickening and a hepatic mass.
  • The surgically resected tumor had a dumbbell shape with gallbladder and liver elements.
  • Histological examination revealed LCNEC in the liver and a deep infiltrative portion of the gallbladder, as well as a well-differentiated tubular adenocarcinoma in the mucosa of the gallbladder.
  • The results suggest a close relationship between LCNEC and adenocarcinoma, and support the theory that these elements originate from common cancer stem cells.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Large Cell / pathology. Carcinoma, Neuroendocrine / pathology. Gallbladder Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

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  • [Copyright] 2009 Elsevier GmbH. All rights reserved.
  • (PMID = 19945229.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen; 0 / Chromogranin A; 0 / Synaptophysin
  • [Number-of-references] 15
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34. Puglisi F, Capuano P, Gentile A, Lobascio P, Russo S, Martines G, Lograno G, Memeo V: Retrobulbar metastasis from gallbladder carcinoma after laparoscopic cholecystectomy. A case report. Tumori; 2005 Sep-Oct;91(5):428-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Retrobulbar metastasis from gallbladder carcinoma after laparoscopic cholecystectomy. A case report.
  • Extra-abdominal metastases from gallbladder cancer are very rare; the sites outside the abdomen most frequently affected are the skin, bone and central nervous system.
  • In the literature, only one case of orbital metastasis from gallbladder cancer has been reported, in a patient previously treated by open cholecystectomy.
  • We report the case of a 53-year-old woman who underwent a laparoscopic cholecystectomy for symptomatic gallbladder stones.
  • Postoperative histological examination revealed an unsuspected gallbladder adenocarcinoma.
  • The few cases of uncommon gallbladder cancer metastases after laparoscopic cholecystectomy described in the literature are discussed, as well as the possible role of laparoscopy in the dissemination and localized seeding of malignant cells.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Cholecystectomy, Laparoscopic. Cholelithiasis / surgery. Gallbladder Neoplasms / diagnosis. Incidental Findings. Orbital Neoplasms / secondary

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  • (PMID = 16459642.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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35. Charalampopoulos A, Lazaris A, Misiakos E, Liakakos S, Macheras A, Peschos D, Batistatou A, Fotiadis K, Charalabopoulos K: Acute septic cholelithiasic cholecystitis and adenocarcinoma of the gallbladder; an interesting association. Acta Gastroenterol Belg; 2007 Jul-Sep;70(3):267-70
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  • [Title] Acute septic cholelithiasic cholecystitis and adenocarcinoma of the gallbladder; an interesting association.
  • BACKGROUND AND STUDY AIMS: Primary carcinoma of the gallbladder may present as acute lithiasic cholecystitis that leads to severe septic complications.
  • The correlation between severe sepsis of the gallbladder and primary carcinoma is unclear.
  • The goal of the present study is to examine the relation between severe septic complications of lithiasic cholecystitis and primary carcinoma of the gallbladder.
  • PATIENTS AND METHODS: A group of 72 patients (22 males, 50 females, age range: 45-99, mean age: 68.6 years), with severe septic cholelithiasic cholecystitis was treated with emergency surgery after failure of conservative treatment, and patients found with primary carcinoma of the gallbladder were registered.
  • RESULTS: During urgent surgery for severe septic lithiasic cholecystitis, 12 patients (12/72, 16.6%) were found with gallbladder carcinoma.
  • CONCLUSIONS: Severe septic complications in elderly patients with a long-standing history of gallbladder stones may co-exist with primary carcinoma of the gallbladder.
  • The percentage of a gallbladder carcinoma detected in septic patients reaches up to 16.6%.
  • The possibility of a carcinoma hidden in the gallbladder must be in mind during surgery.
  • [MeSH-major] Adenocarcinoma / complications. Cholecystitis, Acute / complications. Cholecystolithiasis / complications. Gallbladder Neoplasms / complications. Sepsis / complications

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  • (PMID = 18074735.001).
  • [ISSN] 1784-3227
  • [Journal-full-title] Acta gastro-enterologica Belgica
  • [ISO-abbreviation] Acta Gastroenterol. Belg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Belgium
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36. Albores-Saavedra J, Henson DE, Moran-Portela D, Lino-Silva S: Cribriform carcinoma of the gallbladder: a clinicopathologic study of 7 cases. Am J Surg Pathol; 2008 Nov;32(11):1694-8
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  • [Title] Cribriform carcinoma of the gallbladder: a clinicopathologic study of 7 cases.
  • Carcinomas of the gallbladder are morphologically heterogeneous.
  • We report here the clinicopathologic features of 7 cribriform carcinomas of the gallbladder that resemble cribriform carcinomas of the breast.
  • These 7 patients were younger than those with conventional adenocarcinomas of the gallbladder (average age for males 71 y and average age for females 72 y).
  • None of the 4 cribriform carcinomas of the gallbladder tested showed immunoreactivity for estrogen and progesterone receptors.
  • Three patients with high nuclear grade cribriform carcinomas died as a result of the tumor which infiltrated the liver by direct extension; 3 patients with low nuclear grade cribriform carcinomas confined to the gallbladder wall survived 4 to 7 years after cholecystectomy and 1 patient was lost to follow-up.
  • In conclusion, this study provides support to previous observations that a small proportion of gallbladder carcinomas display an unusual but predominant cribriform pattern similar to that of some invasive breast carcinomas.
  • In contrast to mammary cribriform carcinomas, those arising in the gallbladder occur in individuals usually with gallstones, may coexist with skeletal osteosarcoma, lack estrogen and progesterone receptors, and behave aggressively like conventional adenocarcinomas of the gallbladder.
  • [MeSH-major] Adenocarcinoma / pathology. Gallbladder Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Breast Neoplasms / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 18769339.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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37. Okada K, Kijima H, Imaizumi T, Hirabayashi K, Matsuyama M, Yazawa N, Oida Y, Dowaki S, Tobita K, Ohtani Y, Tanaka M, Inokuchi S, Makuuchi H: Stromal laminin-5gamma2 chain expression is associated with the wall-invasion pattern of gallbladder adenocarcinoma. Biomed Res; 2009 Feb;30(1):53-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Stromal laminin-5gamma2 chain expression is associated with the wall-invasion pattern of gallbladder adenocarcinoma.
  • Our previous study demonstrated that the pT2 and pT3-4 gallbladder carcinomas can be classified into two groups, i.e. infiltrative growth type (IG type) and destructive growth type (DG type) and that the DG type is associated with poor differentiation, aggressive infiltration, and decreased postoperative survival.
  • The present study focused on the clinicopathologic significance of laminin-5gamma2 chain expression as an indicator of local aggressiveness and Ki-67 labeling index (Ki-67 LI) as an indicator of the cell proliferation activity of gallbladder carcinoma.
  • Gallbladder carcinoma cases with high Ki-67 LI were significantly associated with poorly differentiation (P = 0.089) and distant lymph node metastasis (P = 0.079).
  • Laminin-5gamma2 expression patterns of gallbladder carcinoma were divided into two distinct types, extracellular staining and cytoplasmic staining.
  • The cytoplasmic staining was not significantly correlated with invasion pattern in gallbladder carcinoma (P = 0.545).
  • In conclusion, high-grade cell proliferation and stromal laminin-5gamma2 staining were significantly correlated with a wall-invasion pattern of aggressive gallbladder carcinoma indicating destructive growth (DG type).
  • [MeSH-major] Gallbladder Neoplasms / metabolism. Gene Expression Regulation, Neoplastic. Laminin / biosynthesis

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  • (PMID = 19265264.001).
  • [ISSN] 1880-313X
  • [Journal-full-title] Biomedical research (Tokyo, Japan)
  • [ISO-abbreviation] Biomed. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / LAMC2 protein, human; 0 / Laminin
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38. Ooi A, Suzuki S, Nakazawa K, Itakura J, Imoto I, Nakamura H, Dobashi Y: Gene amplification of Myc and its coamplification with ERBB2 and EGFR in gallbladder adenocarcinoma. Anticancer Res; 2009 Jan;29(1):19-26
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  • [Title] Gene amplification of Myc and its coamplification with ERBB2 and EGFR in gallbladder adenocarcinoma.
  • BACKGROUND: Among the combinations of coamplified genes, Myc and ERBB2 or EGFR have attracted much attention for their relevance to cytogenetics, carcinogenesis and cancer therapy.
  • MATERIALS AND METHODS: Gene amplification of Myc, ERBB2 and EGFR were examined on 97 formalin-fixed and paraffin-embedded gallbladder carcinomas, by fluorescence in situ hybridization (FISH).
  • [MeSH-major] Adenocarcinoma / genetics. Gallbladder Neoplasms / genetics. Genes, myc. Receptor, Epidermal Growth Factor / genetics. Receptor, ErbB-2 / genetics

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  • (PMID = 19331129.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2
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39. Oshiro H, Matsuo K, Mawatari H, Inayama Y, Yamanaka S, Nagahama K, Endo I, Shimada H, Nakajima A, Kubota K: Mucin-producing gallbladder adenocarcinoma with focal small cell and large cell neuroendocrine differentiation associated with pancreaticobiliary maljunction. Pathol Int; 2008 Dec;58(12):780-6
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  • [Title] Mucin-producing gallbladder adenocarcinoma with focal small cell and large cell neuroendocrine differentiation associated with pancreaticobiliary maljunction.
  • Herein is reported a case of mucin-producing carcinoma of the gallbladder in a 55-year-old Japanese woman.
  • Although the patient's status and laboratory data initially suggested biliary pancreatitis due to gallstone, radiography and endoscopy confirmed the presence of pancreaticobiliary maljunction and a gallbladder tumor with excessive mucin, in which the duodenal papilla and the common bile duct were impacted.
  • Following surgery, the gallbladder tumor was histopathologically diagnosed as a mixed endocrine-exocrine carcinoma.
  • There was no evidence of lymph node metastasis, distant metastasis, or direct invasion outside the gallbladder.
  • Thus, the final classification of pT2N0M0 stage II was given to this lesion, according to the Union Internationale Contre le Cancer guidelines.
  • Mucin-producing gallbladder carcinoma is a rare clinical condition that can occur in patients with pancreaticobiliary maljunction.
  • [MeSH-major] Adenocarcinoma / pathology. Common Bile Duct / abnormalities. Gallbladder Neoplasms / pathology. Mucins / metabolism. Pancreatic Ducts / abnormalities

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  • (PMID = 19067853.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins
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40. Sato S, Ishii M, Fujihira T, Ito E, Ohtani Y: Gallbladder adenocarcinoma with human chorionic gonadotropin: a case report and review of literature. Diagn Pathol; 2010;5:46
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  • [Title] Gallbladder adenocarcinoma with human chorionic gonadotropin: a case report and review of literature.
  • BACKGROUND: The case of adenocarcinoma with human chorionic gonadtropin (HCG), primary in the male gallbladder, is extremely rare.
  • METHODS: We herein describe a case of primary gallbladder adenocarcinoma associated by ectopic HCG positive tumor cells in a 79-year-old male.
  • RESULTS: Pathological examination showed a mixture of moderately and poorly differentiated adenocarcinoma with ectopic HCG and placental alkaline phosphatase (PlAP) in tumor cells, though the increase of serum or urinary HCG secretion was not confirmed.
  • CONCLUSIONS: A case of gallbladder cancer with ectopic HCG production is quite rare in the literature, though many similar cases in other site, especially in GI tract, are reported.
  • [MeSH-major] Adenocarcinoma / chemistry. Chorionic Gonadotropin / analysis. Gallbladder Neoplasms / chemistry

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  • [Cites] Cancer. 2001 Jan 1;91(1):123-9 [11148568.001]
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  • (PMID = 20594358.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin; 0 / GPI-Linked Proteins; 0 / Isoenzymes; EC 3.1.3.1 / Alkaline Phosphatase; EC 3.1.3.1 / alkaline phosphatase, placental
  • [Other-IDs] NLM/ PMC2910002
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41. Ojima H, Hasegawa T, Matsuno Y, Sakamoto M: Extramedullary myeloid tumour (EMMT) of the gallbladder. J Clin Pathol; 2005 Feb;58(2):211-3
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  • [Title] Extramedullary myeloid tumour (EMMT) of the gallbladder.
  • This report describes a rare case of an extramedullary myeloid tumour (EMMT) of the gallbladder in a patient without leukaemia.
  • Abdominal computed tomography revealed a tumorous mass measuring 6.0 x 4.5 cm and involving the entire gallbladder.
  • A percutaneous needle biopsy was attempted, but because adenocarcinoma could not be completely ruled out, the use of undue force was considered dangerous.
  • Under a preoperative diagnosis of gallbladder carcinoma, a hepatopancreatoduodenectomy was performed.
  • In conclusion, a correct diagnosis of EMMT can be made using appropriate immunohistochemical staining.
  • [MeSH-major] Gallbladder Neoplasms / diagnosis. Sarcoma, Myeloid / diagnosis

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  • [Cites] Arch Pathol Lab Med. 2001 Nov;125(11):1448-52 [11698000.001]
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  • (PMID = 15677545.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD
  • [Other-IDs] NLM/ PMC1770561
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42. Shukla VK, Goel S, Trigun SK, Sharma D: Electrophoretic pattern of proteins in carcinoma of the gallbladder. Eur J Cancer Prev; 2008 Feb;17(1):9-12
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  • [Title] Electrophoretic pattern of proteins in carcinoma of the gallbladder.
  • Carcinoma of the gallbladder is a common health problem in the northern region of India and in spite of improved diagnostic techniques it is generally diagnosed at an advanced stage.
  • This study was carried out in 60 patients, 30 of whom were diagnosed with gallbladder carcinoma and 30 with cholelithiasis.
  • The results showed the mean concentration of total protein in gallbladder tissue of patients with carcinoma of the gallbladder was 51.83 +/- 3.36 mg/g tissue (45.33-57.80) and in patients with cholelithiasis it was 38.82 +/- 9.11 mg/g tissue (29.55-50.99) (P<0.001).
  • Protein electrophoresis of gallbladder tissue from the patients with carcinoma of the gallbladder showed three additional bands of protein (two protein bands were present in the region of 50-55 kDa and the third band was present in the region of 35 kDa), which were absent in the gallbladder tissue of cholelithiasis patients.
  • Mean total protein content in serum was 72.2 +/- 1.73 g/l (67.98-74.99) in patients of carcinoma of the gallbladder, whereas it was 71.01 +/- 3.4 g/l (60.00-78.99) (P>0.05) in the patients with cholelithiasis.
  • Electrophoretic analysis of serum protein revealed at least two additional protein bands in patients with carcinoma of the gallbladder as compared with electrophoretic pattern in cholelithiasis.
  • In conclusion, the presence of these new bands of protein in the gallbladder tissue and serum of the patients with carcinoma of the gallbladder indicate their role in the pathogenesis of the carcinoma of the gallbladder.
  • [MeSH-major] Adenocarcinoma / diagnosis. Blood Proteins / analysis. Cholelithiasis / diagnosis. Electrophoresis, Polyacrylamide Gel. Gallbladder Neoplasms / diagnosis

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  • (PMID = 18090904.001).
  • [ISSN] 0959-8278
  • [Journal-full-title] European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
  • [ISO-abbreviation] Eur. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Blood Proteins
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43. Cho JY, Nam JS, Park MS, Yu JS, Paik YH, Lee SJ, Lee DK, Yoon DS: A Phase II study of capecitabine combined with gemcitabine in patients with advanced gallbladder carcinoma. Yonsei Med J; 2005 Aug 31;46(4):526-31
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  • [Title] A Phase II study of capecitabine combined with gemcitabine in patients with advanced gallbladder carcinoma.
  • The authors evaluated survival, response, and toxicity associated with using a combination of capecitabine and gemcitabine to treat patients with unresectable or metastatic gallbladder adenocarcinoma (GBC).
  • Median age at the time of diagnosis was 62 years (range, 41-78 years).
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Deoxycytidine / analogs & derivatives. Gallbladder Neoplasms / drug therapy

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  • (PMID = 16127778.001).
  • [ISSN] 0513-5796
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Clinical Trial; Clinical Trial, Phase II; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; B76N6SBZ8R / gemcitabine; U3P01618RT / Fluorouracil
  • [Other-IDs] NLM/ PMC2815838
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44. Puia IC, Vlad L, Iancu C, Al-Hajjar N, Pop F, Bălă O, Munteanu D: [Laparoscopic cholecystectomy for porcelain gallbladder]. Chirurgia (Bucur); 2005 Mar-Apr;100(2):187-9
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  • [Title] [Laparoscopic cholecystectomy for porcelain gallbladder].
  • [Transliterated title] Colecistectomie laparoscopică pentru veziculă de porţelan.
  • The porcelain gallbladder is uncommon type of chronically inflamed gallbladder wall considered to be associated with a high frequency of adenocarcinoma and subsequently not suitable for a laparoscopic approach.
  • One conversion was due to an unconfirmed suspicion of gallbladder cancer and the other one to a fistula between the gallbladder and the common bile duct.
  • Patients with a preoperative diagnosis of porcelain gallbladder must not be excluded from the laparoscopic approach yet a low threshold for conversion must be maintained in those with a cancer suspicion.
  • [MeSH-major] Calcinosis / surgery. Cholecystectomy, Laparoscopic. Gallbladder Diseases / surgery
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / etiology. Adenocarcinoma / surgery. Aged. Gallbladder Neoplasms / diagnosis. Gallbladder Neoplasms / etiology. Gallbladder Neoplasms / surgery. Humans. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 15957463.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
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45. Tan Y, Meng HP, Wang FQ, Cheng ZN, Wu Q, Wu HR: [Comparative proteomic analysis of human gallbladder carcinoma]. Zhonghua Zhong Liu Za Zhi; 2010 Jan;32(1):29-32
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  • [Title] [Comparative proteomic analysis of human gallbladder carcinoma].
  • OBJECTIVE: To find out potential molecular targets for gallbladder carcinoma diagnosis and treatment by analyzing and comparing the proteins expressed in human gallbladder carcinoma tissue and benign gallbladder tissue.
  • METHODS: Proteomic analysis of 6 human gallbladder carcinoma tissues and 6 benign gallbladder tissues was carried out.
  • Total proteins of the carcinoma tissue and benign gallbladder tissue were separated by two-dimensional gel electrophoresis (2-DE).
  • There were forty six differentially expressed proteins in the gallbladder carcinom tissues.
  • The increased level of PEBP1 protein in gallbladder carcinoma was further confirmed by immunohistochemical analysis.
  • Those results may provide scientific foundation for screening the molecular biomarkers which can be used in diagnosis and treatment of gallbladder carcinoma, as well as to improve its prognosis and provide a new clue for carcinogenesis research of gallbladder carcinoma.
  • [MeSH-major] Adenocarcinoma / metabolism. Gallbladder Neoplasms / metabolism. Gene Expression Profiling. Phosphatidylethanolamine Binding Protein / metabolism
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Electrophoresis, Gel, Two-Dimensional. Gallstones / diagnosis. Gallstones / metabolism. Gallstones / pathology. Humans. Immunohistochemistry. Middle Aged. Proteomics / methods. Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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  • (PMID = 20211063.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / PEBP1 protein, human; 0 / Phosphatidylethanolamine Binding Protein
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46. Katabi N: Neoplasia of gallbladder and biliary epithelium. Arch Pathol Lab Med; 2010 Nov;134(11):1621-7
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  • [Title] Neoplasia of gallbladder and biliary epithelium.
  • CONTEXT: Diagnosis of biliary neoplasia can be challenging but is essential for the appropriate clinical management of patients.
  • Therefore, it is important to recognize the morphologic features of the biliary neoplasms to report a correct diagnosis. OBJECTIVES:.
  • (1) To discuss the differential diagnosis of dysplasia in the gallbladder and differentiate dysplasia from reactive atypia and invasive carcinoma, (2) review the histologic features of adenoma and polypoid biliary lesions, (3) highlight the differential diagnosis of adenocarcinoma in liver biopsy, and (4) discuss the differential diagnosis of atypical biliary glandular lesions.
  • DATA SOURCES: Current English literature related to gallbladder and biliary neoplasia.
  • Careful examination of the histologic features of these lesions and familiarity with their morphology can help to achieve the correct diagnosis.
  • [MeSH-major] Adenoma / pathology. Bile Duct Neoplasms / pathology. Carcinoma / pathology. Gallbladder Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Metaplasia / pathology

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  • (PMID = 21043815.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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47. Lada PE, Taborda B, Sánchez M, Tommasino J, Rosso FF, Gramática L, Alecha Gil J, Echenique Elizondo M: [Adenosquamous and squamous carcinoma of the gallbladder]. Cir Esp; 2007 Apr;81(4):202-6
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  • [Title] [Adenosquamous and squamous carcinoma of the gallbladder].
  • [Transliterated title] Carcinoma adenoescamoso y epidermoide de la vesícula biliar.
  • INTRODUCTION: Squamous and adenosquamous carcinomas of the gallbladder have poor prognosis.
  • MATERIAL AND METHOD: We performed a retrospective observational study of five patients with squamous or adenosquamous carcinoma of the gallbladder.
  • CONCLUSIONS: In both histological types of gallbladder carcinoma, treatment depends on the grade of local and regional invasion and tumor spread at diagnosis.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Squamous Cell / pathology. Gallbladder Neoplasms / pathology

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  • (PMID = 17403356.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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48. Hattori M, Inui K, Yoshino J, Miyoshi H, Okushima K, Nakamura Y, Naito T, Imaeda Y, Horibe Y, Hattori T, Nakazawa S: [Usefulness of contrast-enhanced ultrasonography in the differential diagnosis of polypoid gallbladder lesions]. Nihon Shokakibyo Gakkai Zasshi; 2007 Jun;104(6):790-8
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  • [Title] [Usefulness of contrast-enhanced ultrasonography in the differential diagnosis of polypoid gallbladder lesions].
  • We investigated the usefulness of contrast-enhanced ultrasonography for differential diagnosis of polypoid gallbladder lesions in 60 patients, consisting of gallbladder carcinoma in 20, adenoma in 2, benign polyp in 29, and adenomyomatosis in 9, comparing contrast enhancement patterns with pathologic findings.
  • When diffuse type and branched type were considered as indicative of cancer, accuracy was 84.5%, sensitivity 100%, and specificity 76.9%.
  • In gallbladder carcinoma, the TIC rose from no contrast to early-phase contrast sooner than in other diseases.
  • In adenocarcinoma, high-intensity values persisted at 120 sec.
  • With an intensity of 90 or greater at 120 sec taken as indicating cancer, accuracy was 89.7%, sensitivity 89.5%, and specificity 89.7%; Vessels were significantly more numerous in diffuse type cases than in those with other patterns.
  • Ultrasonographic contrast enhancement patterns show characteristic associations with pathologic findings and serve as valuable adjuncts in the diagnosis of gallbladder diseases.
  • [MeSH-major] Adenoma / ultrasonography. Gallbladder Neoplasms / ultrasonography. Polyps / ultrasonography. Ultrasonography, Doppler / methods
  • [MeSH-minor] Adenomyoma / pathology. Adenomyoma / ultrasonography. Contrast Media / administration & dosage. Diagnosis, Differential. Humans. Neoplasm Staging

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  • (PMID = 17548945.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Contrast Media
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49. Hatakeyama K, Nagakawa T, Suga T, Miyakawa H, Hirayama A, Matsunaga T, Okamura K, Suzuki H, Honma S, Okada K, Iwaguchi T, Muraoka S: [Carcinoma of the gallbladder which progress on the mucosa of choledochocolonic fistula]. Nihon Shokakibyo Gakkai Zasshi; 2009 Jul;106(7):1063-9
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  • [Title] [Carcinoma of the gallbladder which progress on the mucosa of choledochocolonic fistula].
  • A 70-year-old man was admitted to our hospital for further examination of pneumobilia and atrophy in the gallbladder.
  • Abdominal CT scan and EUS revealed that the atrophic gallbladder was occupied by a tumor lesion.
  • Colonoscopy revealed an elevated lesion in the colonic side of fistula, and biopsy of the elevated lesion revealed adenocarcinoma.
  • Cholecystectomy and right hemicolectomy was performed under a preoperative diagnosis of gallbladder carcinoma with choledochocolonic fistula.
  • Pathologically, most of the tumor was localized in the gallbladder, and grew along the mucosa of choledchocolonic fistula.
  • This case was of interest with regard to the relationship between the choledochocolonic fistula and gallbladder carcinoma.
  • [MeSH-major] Adenocarcinoma / etiology. Biliary Fistula / complications. Colonic Diseases / complications. Common Bile Duct Diseases / complications. Gallbladder Neoplasms / etiology. Intestinal Fistula / complications

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  • (PMID = 19578315.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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50. Kawanishi M, Kuwada Y, Mitsuoka Y, Sasao S, Mouri T, Takesaki E, Takahashi T, Toyota K, Nakatani T: A case of double gallbladder with adenocarcinoma arising from the left hepatic duct: a case report and review of the literature. Gastroenterol Res Pract; 2010;2010

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  • [Title] A case of double gallbladder with adenocarcinoma arising from the left hepatic duct: a case report and review of the literature.
  • Double gallbladder is a rare congenital biliary anomaly, but an accessory gallbladder arising from the left hepatic duct is a more remarkably rare congenital anomaly.
  • We report a case of double gallbladder with adenocarcinoma and gallstones, which was preoperatively diagnosed by endoscopic retrograde cholangiopancreatography (ERCP) and then confirmed by open laparotomy.

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  • (PMID = 20811488.001).
  • [ISSN] 1687-630X
  • [Journal-full-title] Gastroenterology research and practice
  • [ISO-abbreviation] Gastroenterol Res Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2926673
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51. Lee JS, Lee KT, Jung JH, Ok SW, Choi SC, Lee KH, Lee JK, Heo JS, Choi SH, Rhee JC: [Factors associated with malignancy in gallbladder polyps without gallbladder stone]. Korean J Gastroenterol; 2008 Aug;52(2):97-105
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  • [Title] [Factors associated with malignancy in gallbladder polyps without gallbladder stone].
  • BACKGROUND/AIMS: The purpose of this study was to find the factors predicting the neoplastic polyp of gallbladder and analyze the size criteria associated with malignancy.
  • METHODS: A total of 354 subjects with gallbladder polyps confirmed by tissue pathology were included for the analysis.
  • The clinical and radiological features of the polyps were compared between the two groups (neoplastic vs. non-neoplastic) and in the three groups (non-neoplastic vs. adenoma vs. adenocarcinoma).
  • RESULTS: Of 354 patients, non-neoplastic polyps were observed in 229 (64.7%) patents, adenoma in 85 (24.0%) and adenocarcinoma in 40 (11.3%).
  • The mean diameter of non-neoplastic polyp, adenoma, and adenocarcinoma were 11.3+/-2.8 mm, 16.0+/-7.2 mm, and 27.0+/-8.9 mm, respectively.
  • The mean age of patients with non-neoplastic polyp, adenoma, and adenocarcinoma were 44.8+/-11.3, 49.9+/-12.5, and 60.8+/-9.6, respectively.
  • [MeSH-major] Gallbladder Neoplasms / diagnosis. Polyps / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenoma / diagnosis. Adult. Aged. Aged, 80 and over. Data Interpretation, Statistical. Female. Humans. Male. Middle Aged. Odds Ratio. Predictive Value of Tests. ROC Curve

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  • (PMID = 19077501.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
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52. Albores-Saavedra J, Keenportz B, Bejarano PA, Alexander AA, Henson DE: Adenomyomatous hyperplasia of the gallbladder with perineural invasion: revisited. Am J Surg Pathol; 2007 Oct;31(10):1598-604
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  • [Title] Adenomyomatous hyperplasia of the gallbladder with perineural invasion: revisited.
  • We report 9 examples of segmental adenomyomatous hyperplasia of the gallbladder with perineural invasion.
  • Eight patients had gallbladder calculi.
  • The original pathologic diagnosis of adenocarcinoma was made in 5 patients and of "adenoma malignum" in one.
  • The second type was characterized by an extensively fibrotic gallbladder wall with numerous RASs but with few or no smooth muscle bundles and an expanded subserosal layer containing abundant nerve-trunks (3 cases).
  • The pseudoinvasive pattern of the RASs, reactive epithelial atypia, and the perineural and intraneural invasion probably contributed to the erroneous diagnosis of adenocarcinoma or "adenoma malignum."
  • [MeSH-major] Adenomyoma / pathology. Gallbladder / innervation. Gallbladder Diseases / pathology. Peripheral Nervous System / pathology
  • [MeSH-minor] Adenocarcinoma / diagnosis. Aged. Aged, 80 and over. Cholelithiasis / pathology. Cholelithiasis / surgery. Diagnosis, Differential. Female. Humans. Hyperplasia. Male. Middle Aged. Muscle, Smooth. Reoperation

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  • (PMID = 17895763.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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53. Akatsu T, Kameyama K, Kawachi S, Tanabe M, Aiura K, Wakabayashi G, Ueda M, Shimazu M, Kitajima M: Gallbladder carcinoma with osteoclast-like giant cells. J Gastroenterol; 2006 Jan;41(1):83-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gallbladder carcinoma with osteoclast-like giant cells.
  • Occurrence in the gallbladder is extremely rare, with only one previous case.
  • We report here on an additional case of gallbladder carcinoma with an infiltrate of OGCs.
  • A 72-year-old woman presented with postprandial abdominal pain and was found to have a mass in the body of the gallbladder with direct liver invasion.
  • This case adds to a small body of literature on gallbladder carcinoma with OGCs.
  • Further studies are required to clearly define the prognostic significance of these giant cells in gallbladder cancer and the differences between adenosquamous carcinoma with OGCs and other gallbladder carcinomas (such as adenocarcinoma and squamous cell carcinoma) with those cells.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Gallbladder Neoplasms / pathology. Giant Cells / pathology. Osteoclasts / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Prognosis

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  • [Cites] Am J Clin Pathol. 1995 Apr;103(4):453-9 [7726143.001]
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  • (PMID = 16501862.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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54. Kameyama H, Shirai Y, Date K, Kuwabara A, Kurosaki R, Hatakeyama K: Gallbladder carcinoma presenting as exfoliative dermatitis (erythroderma). Int J Gastrointest Cancer; 2005;35(2):153-5
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  • [Title] Gallbladder carcinoma presenting as exfoliative dermatitis (erythroderma).
  • The authors recently encountered a patient with gallbladder carcinoma presenting as erythroderma.
  • After confirming the diagnosis of erythroderma, asymptomatic gallbladder carcinoma was found.
  • Histologic examination of resected specimens revealed poorly differentiated adenocarcinoma with negative resection margins.
  • [MeSH-major] Carcinoma / complications. Dermatitis, Exfoliative / etiology. Gallbladder Neoplasms / complications

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  • (PMID = 15879631.001).
  • [ISSN] 1537-3649
  • [Journal-full-title] International journal of gastrointestinal cancer
  • [ISO-abbreviation] Int J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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55. Varadarajulu S, Eloubeidi MA: Endoscopic ultrasound-guided fine-needle aspiration in the evaluation of gallbladder masses. Endoscopy; 2005 Aug;37(8):751-4
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  • [Title] Endoscopic ultrasound-guided fine-needle aspiration in the evaluation of gallbladder masses.
  • BACKGROUND AND STUDY AIMS: There are very few data on endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) of gallbladder masses.
  • The aim of this study was to assess the utility and safety of EUS-FNA in the evaluation of patients with gallbladder masses.
  • PATIENTS AND METHODS: Six patients who underwent EUS-FNA of gallbladder masses over a 2-year period between 2002 and 2004 were studied retrospectively.
  • Abdominal computed tomography (CT) prior to EUS had revealed a definitive gallbladder mass in only one of the six patients and no gallbladder masses were identified in any of the patients who had undergone prior transabdominal ultrasound.
  • RESULTS: At EUS, all the patients were found to have an echo-poor mass arising from the gallbladder wall or within the lumen of the gallbladder.
  • EUS-FNA of the gallbladder masses revealed adenocarcinoma in five patients and benign disease in one patient.
  • CONCLUSIONS: In patients with obstructive jaundice and equivocal ultrasound or CT findings, evaluation of the gallbladder for the presence of a primary malignancy by EUS is useful.
  • In patients with gallbladder masses, EUS-FNA can be performed safely and can help to make a definitive diagnosis.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / ultrasonography. Endosonography. Gallbladder Neoplasms / pathology. Gallbladder Neoplasms / ultrasonography

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  • (PMID = 16032495.001).
  • [ISSN] 0013-726X
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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56. García P, Manterola C, Araya JC, Villaseca M, Guzmán P, Sanhueza A, Thomas M, Alvarez H, Roa JC: Promoter methylation profile in preneoplastic and neoplastic gallbladder lesions. Mol Carcinog; 2009 Jan;48(1):79-89
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  • [Title] Promoter methylation profile in preneoplastic and neoplastic gallbladder lesions.
  • Gallbladder carcinoma (GBC) is a highly malignant neoplasm and represents the leading cause of cancer death in Chilean women.
  • In order to determine the potential role of promoter methylation in gallbladder carcinogenesis, we investigated the frequency of this epigenetic mechanism by methylation-specific polymerase chain reaction (MSP) in 35 chronic cholecystitis (CC, separated according to the presence or absence of metaplasia), 19 early cancers (mucosa or muscularis propia invasion) and 48 advanced carcinomas with invasion of the gallbladder subserosa (25 cases) and serosa (23 cases).
  • Our findings indicate that aberrant hypermethylation of promoter regions is an early, progressive and cumulative event in gallbladder carcinogenesis.
  • Finally, the methylation status of some individual genes could be useful biomarkers with potential clinical application in diagnosis or prognosis of GBC if they are validated in a greater number of clinical samples.
  • [MeSH-major] Adenocarcinoma / genetics. Cystadenocarcinoma, Serous / genetics. DNA Methylation. Gallbladder Neoplasms / genetics. Precancerous Conditions / genetics. Promoter Regions, Genetic / genetics

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  • (PMID = 18543280.001).
  • [ISSN] 1098-2744
  • [Journal-full-title] Molecular carcinogenesis
  • [ISO-abbreviation] Mol. Carcinog.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Proteins
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57. Medina-Franco H, Ramos-Gallardo G, Orozco-Zepeda H, Mercado-Díaz MA: [Prognostic factor in gallbladder cancer]. Rev Invest Clin; 2005 Sep-Oct;57(5):662-5
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  • [Title] [Prognostic factor in gallbladder cancer].
  • [Transliterated title] Factores pronósticos en cáncer de vesícula.
  • BACKGROUND: Gallbladder cancer is a rare and aggressive neoplasm.
  • OBJECTIVE: The purpose of this manuscript was to evaluate the prognostic factors associated with overall survival in gallbladder cancer patients.
  • METHODS: We performed a retrospective study of the patients with gallbladder cancer who received attention in a tertiary referral center in Mexico City during a 13 year period (1990-2002).
  • Fifty-seven percent of patients had previous diagnosis of cholelithiasis.
  • Ninety-eight percent of the tumors were adenocarcinoma and 25% were poorly differentiated.
  • CONCLUSIONS: Most cases of gallbladder cancer presented with advanced stage.
  • [MeSH-major] Gallbladder Neoplasms / mortality

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  • (PMID = 16419459.001).
  • [ISSN] 0034-8376
  • [Journal-full-title] Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición
  • [ISO-abbreviation] Rev. Invest. Clin.
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
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58. Yamasaki A, Chijiiwa K, Jimi S, Hotokezaka M, Asada T, Etoh T, Naganuma S, Yamaguchi K: Multiseptate gallbladder: report of a case. Hepatogastroenterology; 2008 May-Jun;55(84):859-60
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  • [Title] Multiseptate gallbladder: report of a case.
  • A 53-year-old Japanese female was referred to Miyazaki University hospital for the surgical treatment of gastric cancer.
  • She had no symptoms and the presence of the complex cystic gallbladder with multiple and linear hyperechogenic septa was incidentally found by ultrasonography.
  • Multicystic lesion of gallbladder was also observed on DIC-CT and MRCP.
  • Pathological study of the biopsy specimen from the type 3 tumor of the stomach showed poorly differentiated adenocarcinoma.
  • The gross examination of the gallbladder confirmed the presence of multiple thin septa with honeycomb appearance.
  • Cancer cells were not observed histologically and final diagnosis was the multiseptate gallbladder.
  • We herein report a rare case of multiseptate gallbladder showing the findings on DIC-CT and MRCP.
  • [MeSH-major] Cholangiography. Cholangiopancreatography, Magnetic Resonance. Gallbladder / abnormalities. Image Processing, Computer-Assisted. Imaging, Three-Dimensional. Tomography, X-Ray Computed. Ultrasonography
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Cholecystectomy. Female. Humans. Incidental Findings. Middle Aged. Stomach Neoplasms / diagnosis. Stomach Neoplasms / pathology. Stomach Neoplasms / surgery

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  • (PMID = 18705283.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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59. Huang CP, Chiou YY, Chou YH, Chiang JH, Chang CY: Imaging findings in mucin-producing carcinoma of the gallbladder. J Formos Med Assoc; 2006 May;105(5):427-30
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  • [Title] Imaging findings in mucin-producing carcinoma of the gallbladder.
  • Mucin-producing carcinoma of the gallbladder is rare, and its imaging features have not been well documented.
  • We present a 73-year-old male with mucin-producing carcinoma of the gallbladder, emphasizing its imaging features on ultrasound, computed tomography and magnetic resonance imaging.
  • The tumor usually presents as a cauliflower-like soft tissue mass with small calcified spots in the gallbladder wall and some laminated high viscosity fluid inside the gallbladder cavity.
  • Recognition of these features can provide clues to the diagnosis of mucin-producing carcinoma of the gallbladder.

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  • (PMID = 16638655.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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60. Kimura Y, Kashima K, Daa T, Kondo Y, Yada K, Sasaki A, Matsumoto T, Kitano S, Kubo N, Yokoyama S: Biotin-rich intranuclear inclusions in morule-lacking adenocarcinoma of the gallbladder: a new category of "neoplastic/non-morular" lesions. Virchows Arch; 2005 Feb;446(2):194-9
Hazardous Substances Data Bank. BIOTIN .

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  • [Title] Biotin-rich intranuclear inclusions in morule-lacking adenocarcinoma of the gallbladder: a new category of "neoplastic/non-morular" lesions.
  • In the present report, we describe two cases of well-differentiated adenocarcinoma of the gallbladder in which biotin-rich intranuclear inclusions were found without morular structures.
  • [MeSH-major] Adenocarcinoma / chemistry. Adenocarcinoma / pathology. Biotin / analysis. Cell Nucleus / chemistry. Gallbladder Neoplasms / chemistry. Gallbladder Neoplasms / pathology

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  • (PMID = 15647941.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / Cytoskeletal Proteins; 0 / MUC5AC protein, human; 0 / MUC6 protein, human; 0 / Mucin 5AC; 0 / Mucin-6; 0 / Mucins; 0 / Trans-Activators; 0 / beta Catenin; 6SO6U10H04 / Biotin; EC 4.1.1.41 / Methylmalonyl-CoA Decarboxylase; EC 6.4.1.1 / Pyruvate Carboxylase
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61. Noda H, Chiba F, Toyama N, Konishi F: Mucin-producing carcinoma of the gallbladder associated with primary sclerosing cholangitis and ulcerative colitis. J Hepatobiliary Pancreat Surg; 2009;16(1):83-5
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  • [Title] Mucin-producing carcinoma of the gallbladder associated with primary sclerosing cholangitis and ulcerative colitis.
  • Mucin-producing carcinoma of the gallbladder is very rare.
  • We report here a case of mucin-producing carcinoma of the gallbladder associated with primary sclerosing cholangitis (PSC) and ulcerative colitis (UC).
  • Enhanced computed tomography and ultrasonography showed an enlarged gallbladder associated with wall thickening and diffuse papillary protrusion.
  • Under the diagnosis of an early carcinoma of the gallbladder, we performed simple cholecystectomy.
  • The tumor showed a papillary growth pattern located diffusely in the gallbladder with a massive amount of mucin filling the gallbladder.
  • Histologically, it was diagnosed as a papillary adenocarcinoma localized in the mucosal layer.
  • To the best of our knowledge, this is the first case of mucin-producing carcinoma of the gallbladder associated with PSC and UC.
  • PSC and UC patients should be regarded as a high-risk group not only for cholangiocarcinoma but also carcinoma of the gallbladder.
  • [MeSH-major] Adenocarcinoma, Mucinous / complications. Cholangitis, Sclerosing / complications. Colitis, Ulcerative / complications. Gallbladder Neoplasms / complications

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  • (PMID = 19096754.001).
  • [ISSN] 1436-0691
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Cholagogues and Choleretics; 0 / Gastrointestinal Agents; 119059-81-3 / ursodeoxycholylcysteic acid; 3XC8GUZ6CB / Sulfasalazine; 724L30Y2QR / Ursodeoxycholic Acid; A3OGP4C37W / Cysteic Acid
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62. Miyata H, Sato K, Iwao T, Yoshida K, Usio J, Sato M, Ishino A, Nagata Y, Kawase T, Nomura Y, Morimoto S, Takamori S, Ajioka Y: [Case of gallbladder cancer in which the surface structure of gallbladder was clarified using the endoscopic double contrast cholecystography]. Nihon Shokakibyo Gakkai Zasshi; 2009 May;106(5):684-90
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  • [Title] [Case of gallbladder cancer in which the surface structure of gallbladder was clarified using the endoscopic double contrast cholecystography].
  • A 75-year-old woman was admitted to our hospital with a gallbladder tumor by detected ultrasonography (US).
  • On endoscopic ultrasonography (EUS), and abdominal CT, we diagnosed the Is+IIa+IIb-like ss lesion invasive gallbladder cancer, but endoscopic double contrast cholecystography suggested IIa+IIb-like ss invasive gallbladder cancer because the lesion had the same granular membrane a other cancer membrane and cholecystectomy was carried out.
  • The pathologic diagnosis was IIa+IIb-like ss invasive gallbladder cancer.
  • [MeSH-major] Adenocarcinoma / radiography. Cholecystography. Contrast Media. Endoscopy, Digestive System. Gallbladder Neoplasms / radiography
  • [MeSH-minor] Aged. Cholecystectomy. Female. Gallbladder / pathology. Humans. Neoplasm Invasiveness

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  • (PMID = 19420873.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Contrast Media
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63. Larentzakis A, Theodorou D, Fili K, Manataki A, Bizimi V, Tibishrani M, Katsaragakis S: Sister Mary Joseph's nodule: Three case reports. Cases J; 2008;1(1):182

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  • In the three cases presented, the primary tumor was an adenocarcinona of the sigmoid colon, a carcinoma of the bladder, and an adenocarcinoma of the gallbladder, respectively.
  • CONCLUSION: The differential diagnosis of an umbilical lesion should always include metastatic disease apart from benign lesions and primary neoplasms.

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  • (PMID = 18816407.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2561010
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64. Reid KM, Ramos-De la Medina A, Donohue JH: Diagnosis and surgical management of gallbladder cancer: a review. J Gastrointest Surg; 2007 May;11(5):671-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnosis and surgical management of gallbladder cancer: a review.
  • Gallbladder cancer is one of the most lethal carcinomas and continues to pose many challenges for surgeons.
  • Identifiable risk factors for carcinoma of the gallbladder include cholelithiasis, an anomalous pancreaticobiliary junction, and focal mucosal microcalcifications.
  • Adenocarcinoma is the primary histologic type in most patients and the tumor is frequently associated with Kras and p53 mutations.
  • Current trials are investigating the role of capecitabine, oxaliplatin, and bevacizumab in the management of gallbladder carcinoma.
  • [MeSH-major] Gallbladder Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Carcinoma / diagnosis. Carcinoma / surgery. Cholecystectomy. Diagnostic Imaging. Hepatectomy. Humans. Lymph Node Excision. Neoadjuvant Therapy. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Pancreaticoduodenectomy. Risk Factors

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  • (PMID = 17468929.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 79
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65. Kim JH, Kim WH, Kim JH, Yoo BM, Kim MW: Unsuspected gallbladder cancer diagnosed after laparoscopic cholecystectomy: focus on acute cholecystitis. World J Surg; 2010 Jan;34(1):114-20
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  • [Title] Unsuspected gallbladder cancer diagnosed after laparoscopic cholecystectomy: focus on acute cholecystitis.
  • BACKGROUND: The aim of the present study was to investigate clinicopathological features of patients who were diagnosed with unsuspected gallbladder cancer (UGC) after laparoscopic cholecystectomy (LC) and to clarify the relationship between acute cholecystitis (AC) and unsuspected gallbladder cancer.
  • Twenty-six patients (1.0%) were diagnosed with gallbladder cancer after LC.
  • We excluded patients with preoperatively or intraoperatively suspected gallbladder cancer.
  • RESULTS: Of 1,128 patients with AC, 19 (1.6%) were identified with gallbladder cancer after surgery.
  • The preoperative diagnosis included a high rate of acute and severe acute cholecystitis (n = 19; 73.1%).
  • Adenocarcinoma (92.3%) and pT2 (65.4%) were the most common pathological findings.
  • CONCLUSIONS: The preoperative diagnosis included a high rate of acute and severe acute cholecystitis.
  • Therefore, we suggest that AC may not influence the prognosis of unsuspected gallbladder cancer after LC.
  • [MeSH-major] Cholecystectomy, Laparoscopic. Cholecystitis / complications. Cholecystitis / surgery. Gallbladder Neoplasms / complications. Gallbladder Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Incidental Findings. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Prognosis. Survival Rate

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  • (PMID = 19898893.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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66. Taniguchi H, Sakagami J, Suzuki N, Hasegawa H, Shinoda M, Tosa M, Baba T, Yasuda H, Kataoka K, Yoshikawa T: Adenoendocrine cell carcinoma of the gallbladder clinically mimicking squamous cell carcinoma. Int J Clin Oncol; 2009 Apr;14(2):167-70
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  • [Title] Adenoendocrine cell carcinoma of the gallbladder clinically mimicking squamous cell carcinoma.
  • We present the case of a 62-year-old Japanese man whose histological diagnosis was adenoendocrine cell carcinoma of the gallbladder at autopsy, but whose antemortem diagnosis was squamous cell carcinoma.
  • Abdominal computed tomography revealed a large tumor on the gallbladder involving the adjacent liver, colon, and duodenum, with multiple metastases in the greater omentum and paraportal lymph nodes.
  • Due to these clinical features, we first suspected advanced squamous cell carcinoma of the gallbladder.
  • Though tumor regression was achieved and his serum SCCA level normalized after 3 months, the patient rejected additional chemotherapy and died 8 months after the diagnosis.
  • The case is interesting in that the clinical features were similar to those of squamous cell carcinoma of the gallbladder.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Small Cell / diagnosis. Carcinoma, Squamous Cell / diagnosis. Urinary Bladder Neoplasms / diagnosis

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  • (PMID = 19390950.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Serpins; 0 / squamous cell carcinoma-related antigen
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67. Zins M, Boulay-Coletta I, Molinié V, Mercier-Pageyral B, Jullès MC, Rodallec M, Petit E, Berrod JL: [Imaging of a thickened-wall gallbladder]. J Radiol; 2006 Apr;87(4 Pt 2):479-93
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  • [Title] [Imaging of a thickened-wall gallbladder].
  • [Transliterated title] Imagerie des épaississements de la paroi vésiculaire.
  • Thickening of the gallbladder wall may result from a large spectrum of pathological conditions, intrinsic as well as extrinsic to the biliary tract, and may have different appearances.
  • Accurate diagnosis is usually established after a correlation of imaging findings, laboratory data and clinical history.
  • CT and MRI are complementary to US and have an increasing role in assessing a thickened-wall gallbladder.
  • [MeSH-major] Gallbladder Diseases / diagnosis
  • [MeSH-minor] Acalculous Cholecystitis / diagnosis. Acalculous Cholecystitis / radiography. Acalculous Cholecystitis / ultrasonography. Adenocarcinoma / diagnosis. Adenocarcinoma / radiography. Adenocarcinoma / ultrasonography. Adenoma / diagnosis. Adenoma / radiography. Adenoma / ultrasonography. Adenomyoma / diagnosis. Adenomyoma / radiography. Adenomyoma / ultrasonography. Cholecystitis, Acute / diagnosis. Cholecystitis, Acute / radiography. Cholecystitis, Acute / ultrasonography. Cholecystolithiasis / ultrasonography. Diagnosis, Differential. Female. Gallbladder / pathology. Gallbladder / ultrasonography. Gallbladder Neoplasms / diagnosis. Gallbladder Neoplasms / radiography. Gallbladder Neoplasms / ultrasonography. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 16691177.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 48
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68. Gumbs AA, Kim J, Kiehna E, Brink JA, Salem RR: Autoimmune pancreatitis presenting as simultaneous masses in the pancreatic head and gallbladder. JOP; 2005 Sep;6(5):455-9
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  • [Title] Autoimmune pancreatitis presenting as simultaneous masses in the pancreatic head and gallbladder.
  • Recently, it has been found to be a systemic disease with lymphoplasmacytic infiltration that has been associated with several autoimmune diseases and described in multiple organs including the extrahepatic bile duct, liver and gallbladder.
  • CASE REPORT: We describe the clinical, radiographic and histopathologic aspects of a patient who presented with synchronous masses in the pancreatic head and gallbladder.
  • CONCLUSION: Autoimmune pancreatitis is the most common benign entity identified in patients that underwent pancreaticoduodenectomy for presumed pancreatic adenocarcinoma.
  • Our patient with autoimmune pancreatitis presented with simultaneous inflammatory masses in the gallbladder and pancreatic head, an association not previously reported.
  • If pre-operative diagnosis is not made, immunohistochemical staining of pathology specimens can confirm the diagnosis.
  • [MeSH-major] Autoimmune Diseases / diagnosis. Autoimmune Diseases / pathology. Gallbladder / pathology. Pancreas / pathology. Pancreatitis / diagnosis. Pancreatitis / pathology
  • [MeSH-minor] Acute Disease. Aged. Edema / diagnosis. Edema / pathology. Female. Humans. Immunoglobulin G / analysis. Immunoglobulin G / blood. Immunohistochemistry. Tomography, X-Ray Computed

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  • (PMID = 16186668.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Immunoglobulin G
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69. Sośnik H, Sośnik K: Double cancer of the gallbladder--a case report. Pol J Pathol; 2006;57(4):213-5
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  • [Title] Double cancer of the gallbladder--a case report.
  • The study presented the coexistence of papillary adenocarcinoma and microcellular neuroendocrine carcinoma of the gallbladder in a 56-year old female patient without cholelithiasis and developmental anomalies of the biliary-pancreatic ducts.
  • Considering the material obtained by the authors (94 cases), the above-mentioned was diagnosed in 1,06% of gallbladder carcinomas.
  • The authors analyzed literature data and considered pathogenetic factors, responsible for development of two gallbladder carcinomas.
  • [MeSH-major] Adenocarcinoma, Papillary / diagnosis. Carcinoma, Neuroendocrine / diagnosis. Gallbladder Neoplasms / diagnosis. Neoplasms, Multiple Primary

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  • (PMID = 17285766.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Poland
  • [Number-of-references] 8
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70. Joo HJ, Kim GH, Jeon WJ, Chae HB, Park SM, Youn SJ, Choi JW, Sung R: Metachronous bile duct cancer nine years after resection of gallbladder cancer. World J Gastroenterol; 2009 Jul 21;15(27):3440-4
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  • [Title] Metachronous bile duct cancer nine years after resection of gallbladder cancer.
  • We report a rare case of a 74-year-old man with metachronous gallbladder cancer and bile duct cancer who underwent curative resection twice, with the operations nine years apart.
  • At the age of 65 years, the patient underwent a cholecystectomy and resection of the liver bed for gallbladder cancer.
  • This was a well-differentiated adenocarcinoma, with negative resection margins (T2N0M0, stage IB).
  • We diagnosed this lesion as a perihilar bile duct cancer, Bismuth type IIIa, and performed bile duct excision, right hepatic lobectomy and Roux-en-Y hepaticojejunostomy.
  • The histological diagnosis was a well-differentiated adenocarcinoma with one regional lymph node metastasis (T1N1M0, stage IIB).
  • This case is compared with 11 other cases of metachronous biliary tract cancer published in the world medical literature.
  • [MeSH-major] Adenocarcinoma / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Gallbladder Neoplasms / pathology. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Treatment Outcome. Young Adult

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  • (PMID = 19610150.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2712910
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71. Teo CH, Leow CK, Chang SA: A pseudoepidermoid cyst arising from exuberant squamous metaplasia of the gallbladder. Arch Pathol Lab Med; 2005 Jun;129(6):e138-40
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  • [Title] A pseudoepidermoid cyst arising from exuberant squamous metaplasia of the gallbladder.
  • Squamous lesions of the gallbladder are uncommon.
  • We report a case of a pseudoepidermoid cyst in a middle-aged woman arising on a background of chronic cholecystitis and cholelithiasis, which induced exuberant squamous metaplasia of the entire gallbladder mucosa, clinically mimicking a gallbladder tumor.
  • [MeSH-major] Epidermal Cyst / pathology. Gallbladder Diseases / pathology. Mucous Membrane / pathology
  • [MeSH-minor] Adenocarcinoma / diagnosis. Biomarkers / metabolism. Cholecystitis / complications. Cholecystitis / pathology. Cholecystitis / surgery. Choledocholithiasis / complications. Choledocholithiasis / pathology. Choledocholithiasis / surgery. Chronic Disease. Common Bile Duct / pathology. Common Bile Duct / surgery. Diagnosis, Differential. Female. Gallbladder Neoplasms / diagnosis. Hepatic Duct, Common / pathology. Hepatic Duct, Common / surgery. Humans. Immunohistochemistry. Jejunostomy. Metaplasia / pathology. Middle Aged. Treatment Outcome

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  • (PMID = 15913441.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers
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72. Piekarski JH, Kusinska R, Nejc D, Pluta P, Sek P, Bilski A, Durczynski A, Kubiak R, Pasz-Walczak G, Jeziorski A: Recurrence of cholangiogenous carcinoma in port-sites two years after laparoscopic removal of noncancerous gallbladder. Eur J Gastroenterol Hepatol; 2008 May;20(5):474-7

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  • [Title] Recurrence of cholangiogenous carcinoma in port-sites two years after laparoscopic removal of noncancerous gallbladder.
  • Analysis of morphology and cytokeratin profile (CK19+ and CK20+/-) of resected port-site tumor allows us to establish the diagnosis of tubular carcinoma with probable cholangiogenic origin.
  • The primary carcinoma was not diagnosed in archival gallbladder tissue, despite repeated histological examination.
  • Patient history and histological/immunohistochemical picture of the recurrent tumor suggested that primary carcinoma was probably located in the gallbladder, but was not detected during initial and repeated histological examinations of postoperative specimen.
  • [MeSH-major] Abdominal Wall. Adenocarcinoma / secondary. Cholecystectomy, Laparoscopic / adverse effects. Cholecystitis / surgery. Neoplasms, Unknown Primary

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  • (PMID = 18403952.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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73. Murguia E, Quiroga D, Canteros G, Sanmartino C, Barreiro M, Herrera J: Gallbladder metastases from ductal papillary carcinoma of the breast. J Hepatobiliary Pancreat Surg; 2006;13(6):591-3
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  • [Title] Gallbladder metastases from ductal papillary carcinoma of the breast.
  • Breast cancer occurs primarily in women aged 25 years or older.
  • The gallbladder was hydropic; the wall was thickened, with a focal broad-based lesion on the mesenteric face of the body.
  • Histopathological evaluation of the focal broad-based lesion of the gallbladder revealed poorly differentiated adenocarcinoma infiltration, without mucosal involvement.
  • The final pathological diagnosis was breast ductal papillary carcinoma metastases to the gallbladder.
  • A literature review revealed only a few more cases of metastasic breast carcinoma to the gallbladder.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / pathology. Gallbladder Neoplasms / secondary

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  • (PMID = 17139439.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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74. Yamamoto A, Ozeki Y, Ito Y, Horita R, Saji S, Sugiyama H, Matsunaga K: [A case of well differentiated mucinous carcinoma of the gallbladder]. Nihon Shokakibyo Gakkai Zasshi; 2010 Nov;107(11):1821-7
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  • [Title] [A case of well differentiated mucinous carcinoma of the gallbladder].
  • We report a case of well differentiated mucinous carcinoma of the gallbladder.
  • An 80-year-old man was admitted to our hospital because of fever and CT showed a mass in the fundus of the gallbladder and choledocholithiasis.
  • Abdominal ultrasonography and CT showed a 4 cm mass in the fundus of the gallbladder.
  • Based on a diagnosis of adenomyomatosis or mucinous carcinoma of the gallbladder, a laparotomy revealed a white mass in the fundus of gallbladder.
  • Intra-operative pathological diagnosis of lymph node of cystic duct was mucinous carcinoma.
  • Pathological diagnosis confirmed well differentiated mucinous carcinoma of the gallbladder.
  • [MeSH-major] Adenocarcinoma, Mucinous. Gallbladder Neoplasms

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  • (PMID = 21071900.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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75. Handa U, Nanda A, Mohan H, Kochhar S, Sachdev A: Cytologic diagnosis of gallbladder lesions - A study of 150 cases. Indian J Surg; 2010 Jun;72(3):181-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytologic diagnosis of gallbladder lesions - A study of 150 cases.
  • AIMS AND OBJECTIVES: Gallbladder (GB) carcinoma is among the five most common forms of gastrointestinal cancers and the diagnosis is usually made when the carcinoma is already in an advanced stage.
  • Adenocarcinoma was the most common morphologic type.
  • CONCLUSION: US guided FNA provides a rapid and reliable diagnosis in cases of GB carcinoma.

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  • [Cites] Dig Dis. 1992;10(3):121-33 [1319288.001]
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  • (PMID = 23133243.001).
  • [ISSN] 0972-2068
  • [Journal-full-title] The Indian journal of surgery
  • [ISO-abbreviation] Indian J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3452654
  • [Keywords] NOTNLM ; Aspiration cytology / Gallbladder / Ultrasonography
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76. Mayo SC, Shore AD, Nathan H, Edil B, Wolfgang CL, Hirose K, Herman J, Schulick RD, Choti MA, Pawlik TM: National trends in the management and survival of surgically managed gallbladder adenocarcinoma over 15 years: a population-based analysis. J Gastrointest Surg; 2010 Oct;14(10):1578-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] National trends in the management and survival of surgically managed gallbladder adenocarcinoma over 15 years: a population-based analysis.
  • INTRODUCTION: National Comprehensive Cancer Network (NCCN) guidelines recommend hepatic resection and lymphadenectomy (LND) for gallbladder adenocarcinoma (GBA).
  • METHODS: Using Surveillance, Epidemiology and End Results (SEER)-Medicare-linked data, we identified 2,955 patients with GBA who underwent cancer-directed surgery from 1991 to 2005.
  • [MeSH-major] Adenocarcinoma / surgery. Gallbladder Neoplasms / surgery. SEER Program

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  • (PMID = 20824371.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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77. Ramos-Font C, Santiago Chinchilla A, Rodríguez-Fernández A, Rebollo Aguirre AC, Gómez Río M, Llamas Elvira JM: [Gallbladder cancer staging with 18F-FDG PET-CT]. Rev Esp Med Nucl; 2009 Mar-Apr;28(2):74-7
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  • [Title] [Gallbladder cancer staging with 18F-FDG PET-CT].
  • [Transliterated title] Estadificación del cáncer de vesícula mediante tomografía de positrones con 18F-fluorodesoxiglucosa.
  • Gallbladder cancer is the most common biliary tract neoplasm.
  • Late diagnosis of the disease indicates a poor prognosis for these patients.
  • Positron emission tomography (PET) with fluorodeoxyglucose (FDG) with dedicated scanners or hybrid PET-CT scans are new diagnostic tools which could help in the pre-surgical diagnosis of these tumours.
  • We present three cases to illustrate the usefulness of PET-FDG in the pre-surgical staging of gallbladder cancer.
  • [MeSH-major] Adenocarcinoma / radionuclide imaging. Fluorine Radioisotopes. Fluorodeoxyglucose F18. Gallbladder Neoplasms / radionuclide imaging. Neoplasm Staging / methods. Positron-Emission Tomography. Radiopharmaceuticals

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  • (PMID = 19406053.001).
  • [ISSN] 0212-6982
  • [Journal-full-title] Revista española de medicina nuclear
  • [ISO-abbreviation] Rev Esp Med Nucl
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Fluorine Radioisotopes; 0 / Radiopharmaceuticals; 0W860991D6 / Deoxycytidine; 0Z5B2CJX4D / Fluorodeoxyglucose F18; B76N6SBZ8R / gemcitabine
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78. Hijioka S, Mekky MA, Bhatia V, Sawaki A, Mizuno N, Hara K, Hosoda W, Shimizu Y, Tamada K, Niwa Y, Yamao K: Can EUS-guided FNA distinguish between gallbladder cancer and xanthogranulomatous cholecystitis? Gastrointest Endosc; 2010 Sep;72(3):622-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Can EUS-guided FNA distinguish between gallbladder cancer and xanthogranulomatous cholecystitis?
  • BACKGROUND: EUS-guided FNA (EUS-FNA) is a useful modality for sampling various targets, but its applicability to gallbladder (GB) mass lesions is limited.
  • The final diagnosis was based on surgical histopathological results or follow-up outcome.
  • Adenocarcinoma was confirmed by EUS-FNA in 8 of the 9 patients with suspected unresectable GB carcinoma, and the FNA was inconclusive in one.
  • The accuracy of EUS-FNA for detecting malignancy and for the final diagnosis was 93.3% (95% CI, 62.4%-99.9%) and 80% (95% CI, 54%-93.7%), respectively.
  • [MeSH-major] Biopsy, Fine-Needle. Endosonography. Gallbladder Neoplasms / pathology. Gallbladder Neoplasms / ultrasonography. Ultrasonography, Interventional
  • [MeSH-minor] Aged. Aged, 80 and over. Cholecystitis / pathology. Cholecystitis / ultrasonography. Diagnosis, Differential. Female. Gallbladder / pathology. Gallbladder / ultrasonography. Granuloma / pathology. Granuloma / ultrasonography. Humans. Lymph Nodes / pathology. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Xanthomatosis / pathology. Xanthomatosis / ultrasonography

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  • [Copyright] Copyright 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20630515.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] Xanthogranulomatous cholecystitis
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79. Iqbal M, Gondal KM, Qureshi AU, Tayyab M: Comparative study of ultrasound guided fine needle aspiration cytology with open/laparoscopic biopsy for diagnosis of carcinoma gallbladder. J Coll Physicians Surg Pak; 2009 Jan;19(1):17-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative study of ultrasound guided fine needle aspiration cytology with open/laparoscopic biopsy for diagnosis of carcinoma gallbladder.
  • OBJECTIVE: To determine the accuracy of Fine Needle Aspiration Cytology (FNAC) in cases of gallbladder mass.
  • RESULTS: Fifty cases with mean age 60.71+11.073 years presented with mass gallbladder underwent FNAC.
  • Smears showed adenocarcinoma 23, undifferentiated carcinoma in 7, dysplasia and suspicion of malignancy in 5, hemorrhagic background without malignant cells in 12 and inflammatory cells with no malignancy in 3 cases.
  • [MeSH-major] Adenocarcinoma / pathology. Biopsy, Needle / methods. Gallbladder Neoplasms / pathology. Ultrasonography, Interventional / methods

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  • (PMID = 19149974.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Pakistan
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80. Lohsiriwat V, Vongjirad A, Lohsiriwat D: Value of routine histopathologic examination of three common surgical specimens: appendix, gallbladder, and hemorrhoid. World J Surg; 2009 Oct;33(10):2189-93
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  • [Title] Value of routine histopathologic examination of three common surgical specimens: appendix, gallbladder, and hemorrhoid.
  • BACKGROUND: The purpose of this study was to assess the need for a routine histopathologic examination of three common surgical specimens (appendix, gallbladder, hemorrhoid) and its impact on the further management of the patients.
  • The reports were excluded if patients had a clinical diagnosis or suspicion of malignancy.
  • RESULTS: Of 4545 appendectomy specimens, 44 (0.97%) revealed incidental unexpected pathological diagnoses, including one adenocarcinoma and one primary appendiceal lymphoma.
  • Unexpected pathologic gallbladder findings were found in 88 (2%) of 4317 cholecystectomy specimens.
  • Gallbladder cancer (GBC) was detected in 24 specimens (0.56%).
  • A clinical diagnosis of empyema and patient's age over 60 years were two significant risk factors for an unexpected GBC [odds ratio (OR) 11.0, 95% confidence interval (CI) 4.2-29.2 and OR 6.2, 95% CI 2.1-18.2, respectively].
  • About one-fourth of patients with unexpected gallbladder findings required further management.
  • CONCLUSIONS: The routine histopathology examination of the appendix and gallbladder, particularly in cases of empyema and patient's age over 60 years, is of value for identifying unsuspected conditions requiring further postoperative management.
  • [MeSH-major] Appendix / pathology. Diagnostic Tests, Routine. Gallbladder / pathology. Hemorrhoids / pathology

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  • (PMID = 19669232.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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81. Yokomuro S, Arima Y, Mizuguchi Y, Shimizu T, Kawahigashi Y, Kannda T, Arai M, Tajiri T: Occult gallbladder carcinoma after laparoscopic cholecystectomy: a report of four cases. J Nippon Med Sch; 2007 Aug;74(4):300-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Occult gallbladder carcinoma after laparoscopic cholecystectomy: a report of four cases.
  • Of these patients, 4 (4.7%) were found to have occult gallbladder carcinoma (GC) either during or after the procedure.
  • The prevalence of gallbladder carcinoma has recently been increasing.
  • Because flat infiltrating GC and GC with cholecystitis and numerous stones are difficult to diagnose preoperatively, we recommend taking frozen sections from patients who are of advanced age (older than 70 years), have a long history of stones, or have a thickened gallbladder wall.
  • [MeSH-major] Adenocarcinoma / diagnosis. Cholecystectomy, Laparoscopic. Gallbladder Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Gallstones / surgery. Humans. Male. Neoplasms, Unknown Primary / diagnosis

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  • (PMID = 17878700.001).
  • [ISSN] 1345-4676
  • [Journal-full-title] Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
  • [ISO-abbreviation] J Nippon Med Sch
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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82. Carlomagno C, Insabato L, Bifulco G, De Placido S, Lauria R: Ovarian metastasis following gallbladder carcinoma: a case report. Eur J Gynaecol Oncol; 2010;31(2):219-21
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  • [Title] Ovarian metastasis following gallbladder carcinoma: a case report.
  • BACKGROUND: Mucinous ovarian cancer raises problems of differential diagnoses because it is often difficult to distinguish the primary from the metastatic form.
  • Most metastatic ovarian tumors originate from the gastrointestinal tract, mainly colorectal, gastric, pancreatic; the gallbladder is a very rare source of ovarian metastases.
  • CASE: We report a case of ovarian metastases from a gallbladder cancer, incidentally diagnosed more than 2.5 years earlier during a laparoscopic intervention for biliary lithiasis.
  • CONCLUSION: The interest of this case lies in the long progression-free survival, the venous thromboembolism syndrome that preceded by a few months the diagnosis of the ovarian mass and the discrepancy between the radiologic and the laparoscopic stage assessment.
  • [MeSH-major] Adenocarcinoma / secondary. Gallbladder Neoplasms / pathology. Ovarian Neoplasms / secondary

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  • (PMID = 20527247.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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83. Tan Y, Meng HP, Wu Q, Wang FQ, Wu HR: [Proteomic study of gallbladder cancer, with special reference on the expression and significance of annexin A3]. Zhonghua Bing Li Xue Za Zhi; 2010 Jun;39(6):382-6
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  • [Title] [Proteomic study of gallbladder cancer, with special reference on the expression and significance of annexin A3].
  • OBJECTIVE: To explore the potential molecular targets for diagnosis and treatment of gallbladder cancer by analyzing and comparing the proteomes expressed in human gallbladder cancer and benign gallbladder tissues.
  • AnnexinA3 expression was examined by streptavidin peroxidase immunohistochemical technique on paraffin-embedded tissue sections from 50 patients of gallbladder cancer and 38 cases of chronic eholecystitis.
  • There were forty six differentially expressed proteins in the tissue samples of gallbladder cancer.
  • The positive expression rates of annexinA3 in gallbladder cancer was significantly higher than that in chronic cholecystitis, and the difference was statistically significant (74.0% vs 21.1%, P < 0.01).
  • In the gallbladder cancer, no correlation was obtained between annexinA3 and age, gender or histologicl type (P > 0.05), but overexpression of annexinA3 correlated significantly with those cases with a lower histological grading (40.0% vs 82.5%, P < 0.05); lymph node or distant metastasis (40.9% vs 100%, P < 0.05); or a shorter survival time after operation (50.0% vs 93.8%, P < 0.05).
  • CONCLUSIONS: Significant discrepancies in protein expression exist among gallbladder cancer and benign gallbladder tissues.
  • AnnexinA3 plays an important role in the initiation and progression of human gallbladder cancer.
  • [MeSH-major] Adenocarcinoma / metabolism. Annexin A3 / metabolism. Gallbladder Neoplasms / metabolism. Gene Expression Profiling

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  • (PMID = 21055154.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Proteome; EC 3.1.4.43 / Annexin A3
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84. Khoo JJ, Nurul AM: A clinicopathological study of nine cases of gallbladder carcinoma in 1122 cholecystectomies in Johor, Malaysia. Malays J Pathol; 2008 Jun;30(1):21-6
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  • [Title] A clinicopathological study of nine cases of gallbladder carcinoma in 1122 cholecystectomies in Johor, Malaysia.
  • An audit of 1122 cholecystectomies for a 6-year period from 2000 to 2005 was done to review cases of primary carcinoma of gallbladder.
  • There were nine cases of primary carcinoma of gallbladder.
  • Intra-operatively, an additional four cases were suspected as gallbladder carcinoma with the remaining three cases diagnosed as only having gallstones.
  • Six (66.67%) cases of gallbladder carcinoma had abnormal macroscopical lesions noted; either papillary lesions or polypoid masses.
  • Seven cases were found histologically to be adenocarcinoma.
  • Of these, two were papillary carcinoma and one signet ring cell type adenocarcinoma.
  • This study highlights the importance of careful macroscopical and microscopical evaluation of a routine pathological examination of gallbladder removed for cholecystitis or cholelithiasis.
  • It provides the incidence of gallbladder carcinoma in patients who underwent cholecystectomies in a government hospital in Johor, Malaysia.
  • [MeSH-major] Carcinoma / pathology. Gallbladder Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cholecystectomy. Cholecystitis / complications. Cholecystitis / pathology. Diagnosis, Differential. Female. Gallstones / complications. Gallstones / pathology. Humans. Malaysia. Male. Middle Aged. Retrospective Studies

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  • (PMID = 19108407.001).
  • [ISSN] 0126-8635
  • [Journal-full-title] The Malaysian journal of pathology
  • [ISO-abbreviation] Malays J Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Malaysia
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85. Zielinski MD, Atwell TD, Davis PW, Kendrick ML, Que FG: Comparison of surgically resected polypoid lesions of the gallbladder to their pre-operative ultrasound characteristics. J Gastrointest Surg; 2009 Jan;13(1):19-25
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  • [Title] Comparison of surgically resected polypoid lesions of the gallbladder to their pre-operative ultrasound characteristics.
  • BACKGROUND: Polypoid lesions of the gallbladder (PLG) have been a common finding on ultrasound examinations of the abdomen and are more prevalent since our use of equipment incorporating pulse shaping increased bandwidth, and enhanced phase use for image reconstruction began in 1996.
  • METHODS: A retrospective review was performed of 130 patients who had a pre-operative ultrasound of the gallbladder and subsequently underwent cholecystectomy between August 1996 and July 2007 at the Mayo Clinic Rochester.
  • Of these, there were 23 pseudopolyps and six true polyps with neoplastic changes on final pathology (four dysplastic adenomas and two adenocarcinomas).
  • Three asymptomatic polyps < or = 10 mm (4%) in maximum diameter based on pre-operative ultrasound imaging (US) had neoplastic changes at pathology (two dysplastic adenomas and one adenocarcinoma).
  • CONCLUSION: Histopathologic analysis of polypoid lesions of the gallbladder continues to be the gold standard to identify malignancy.
  • [MeSH-major] Cholecystectomy. Gallbladder Neoplasms / ultrasonography. Polyps / ultrasonography. Preoperative Care / methods
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Reproducibility of Results. Retrospective Studies

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  • (PMID = 18972168.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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86. Hosaka A, Nagayoshi M, Sugizaki K, Masaki Y: Gallbladder perforation associated with carcinoma of the duodenal papilla: a case report. World J Surg Oncol; 2010;8:41
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  • [Title] Gallbladder perforation associated with carcinoma of the duodenal papilla: a case report.
  • BACKGROUND: Gallbladder perforation is a rare clinical condition, which mostly occurs following acute cholecystitis associated with cholelithiasis.
  • A tumor of the ampulla of Vater causes gradually progressive symptoms, and is rarely associated with perforation of the gallbladder.
  • CASE PRESENTATION: A 56-year-old man with carcinoma of the ampulla of Vater presented with spontaneous gallbladder perforation and localized bile peritonitis.
  • He complained of right upper abdominal pain, and laparotomy revealed perforation of the gallbladder with no gallstones.
  • Postoperative upper gastrointestinal endoscopy demonstrated a slightly enlarged duodenal papilla, and biopsy revealed adenocarcinoma of the ampulla.
  • CONCLUSION: Ampullary carcinoma can be associated with gallbladder perforation and present with acute manifestations.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. Gallbladder / pathology. Gallbladder Diseases / diagnosis
  • [MeSH-minor] Abdominal Pain. Humans. Male. Middle Aged. Pancreaticoduodenectomy. Peritonitis / diagnosis. Rupture, Spontaneous. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 20487525.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2887867
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87. Fujita T, Fukuda K, Ohmura Y, Nishi H, Mano M, Komatsubara S, Doihara H, Shimizu N: Long-term survival of a patient with advanced adenosquamous carcinoma of the gallbladder after radical resection. J Hepatobiliary Pancreat Surg; 2005;12(2):147-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term survival of a patient with advanced adenosquamous carcinoma of the gallbladder after radical resection.
  • Patients with adenosquamous carcinoma of the gallbladder tend to present with a bulky tumor that frequently displays involvement with adjacent organs, and diagnosis is usually made at an advanced stage.
  • This may contribute to the poor prognosis of patients with adenosquamous carcinoma of the gallbladder compared to patients with adenocarcinoma.
  • We present herein a patient with advanced adenosquamous carcinoma of the gallbladder who is doing well with no evidence of recurrence more than 5 years after radical resection.
  • On admission, abdominal ultrasonography and computed tomography revealed an irregularly shaped solid mass extending from the fundus of the gallbladder, and invasion of the stomach was strongly suspected.
  • Gallbladder carcinoma was diagnosed, and radical resection, including partial gastrectomy, was performed.
  • [MeSH-major] Carcinoma, Adenosquamous / surgery. Gallbladder Neoplasms / surgery

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  • (PMID = 15868080.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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88. Scaringi S, Nesi G, Bargellini T, Batignani G, Tonelli F: Iterative surgical resection of a recurrent gallbladder carcinoma with long-term survival: report of a case. In Vivo; 2010 Mar-Apr;24(2):215-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Iterative surgical resection of a recurrent gallbladder carcinoma with long-term survival: report of a case.
  • Gallbladder carcinoma is a rare, but often lethal disease.
  • Unfortunately, at the time of diagnosis, patients usually have advanced disease (T3-T4) and long-term survival is dismal, ranging from 5 to 12% in the literature.
  • However, this cancer can be successfully treated when the tumour is organ-confined (T1-T2 tumours), as happens in the case of incidental diagnosis at the time of cholecystectomy for gallstones.
  • Here we describe a patient with recurrent gallbladder carcinoma who, treated with iterative surgical resection, is alive and disease-free at 5 years after the final surgical procedure.
  • [MeSH-major] Adenocarcinoma / surgery. Gallbladder Neoplasms / surgery. Liver Neoplasms / surgery. Neoplasm Recurrence, Local / surgery

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  • (PMID = 20363997.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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89. Lam CM, Yuen AW, Wai AC, Leung RM, Lee AY, Ng KK, Fan ST: Gallbladder cancer presenting with acute cholecystitis: a population-based study. Surg Endosc; 2005 May;19(5):697-701
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  • [Title] Gallbladder cancer presenting with acute cholecystitis: a population-based study.
  • The aim of the present study was to determine the incidence, clinicopathological characteristics, and outcome of patients with gallbladder cancer presenting with acute cholecystitis.
  • METHODS: We performed a retrospective analysis of patients with gallbladder cancer who presented with acute cholecystitis and were treated at the public hospitals in Hong Kong between 1998 and 2002.
  • RESULTS: Among 2,700 patients with acute cholecystitis managed with cholecystectomy (1,347 open and 1,353 LC), 63 patients (2.3%) were found to have gallbladder cancer.
  • Adenocarcinoma (90.5%) was the most common cancer.
  • CONCLUSIONS: In the ethnic Chinese population of Hong Kong, the incidence of gallbladder cancer presenting with acute cholecystitis is higher than the same finding in patients undergoing elective cholecystectomy for cholelithiasis.
  • [MeSH-major] Adenocarcinoma / diagnosis. Cholecystitis / etiology. Gallbladder Neoplasms / diagnosis
  • [MeSH-minor] Acute Disease. Aged. Aged, 80 and over. Breast Neoplasms. Carcinoma, Adenosquamous / diagnosis. Carcinoma, Adenosquamous / surgery. Carcinoma, Ductal, Breast / secondary. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / surgery. Cholecystectomy, Laparoscopic. Cholelithiasis / epidemiology. Cholelithiasis / surgery. Comorbidity. Elective Surgical Procedures / statistics & numerical data. Female. Hong Kong / epidemiology. Hospital Mortality. Humans. Incidence. Incidental Findings. Life Tables. Lymphoma / diagnosis. Lymphoma / surgery. Male. Middle Aged. Neoplasm Seeding. Retrospective Studies. Survival Analysis. Survival Rate. Treatment Outcome

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  • [Cites] Lancet. 1998 Jan 31;351(9099):321-5 [9652612.001]
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  • (PMID = 15776204.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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90. Jahan M, Xiao P, Go A, Cheema M, Hameed A: Intraductal and invasive adenocarcinoma of duct of Luschka, mimicking chronic cholecystitis and cholelithiasis. World J Surg Oncol; 2009;7:4
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  • [Title] Intraductal and invasive adenocarcinoma of duct of Luschka, mimicking chronic cholecystitis and cholelithiasis.
  • BACKGROUND: Intraductal and invasive adenocarcinoma of duct of Luschka is rare.
  • Ultrasound examination revealed thickening of gallbladder wall with abnormal septation around liver bed.
  • Histologic examination confirmed an intraductal and invasive adenocarcinoma arising from Luschka ducts.
  • CONCLUSION: Adenocarcinoma of ducts of Luschka should be considered among differential diagnoses for the patients with typical clinical presentations of chronic cholecystitis and cholelithiasis.
  • [MeSH-major] Adenocarcinoma / diagnosis. Bile Duct Neoplasms / diagnosis. Cholecystectomy, Laparoscopic. Cholecystitis / diagnosis. Cholelithiasis / diagnosis
  • [MeSH-minor] Adult. Chronic Disease. Diagnosis, Differential. Female. Humans. Liver Neoplasms / secondary. Liver Neoplasms / surgery. Neoplasm Invasiveness

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  • [Cites] J Hepatobiliary Pancreat Surg. 2001;8(5):494-8 [11702263.001]
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  • (PMID = 19128463.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2631453
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91. Matsutani T, Uchida E, Yokoyama T, Matsushita A, Matsuda A, Sasajima K: A case of unresectable gallbladder cancer responding to gemcitabine after metallic biliary stent implantation. J Nippon Med Sch; 2009 Oct;76(5):253-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of unresectable gallbladder cancer responding to gemcitabine after metallic biliary stent implantation.
  • She underwent exploratory laparotomy under a diagnosis of advanced biliary tract cancer.
  • Histological examination of a biopsy specimen of the gallbladder revealed adenocarcinoma.
  • Gemcitabine therapy after metallic biliary stent implantation might be safe and effective in patients with unresectable gallbladder cancer.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antimetabolites, Antineoplastic / administration & dosage. Deoxycytidine / analogs & derivatives. Gallbladder Neoplasms / drug therapy. Stents

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  • (PMID = 19915309.001).
  • [ISSN] 1345-4676
  • [Journal-full-title] Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
  • [ISO-abbreviation] J Nippon Med Sch
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Metals; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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92. Liu DC, Yang ZL, Yang LP: [Expression of enhancer of zesle homolog 2 and phosphatase and tension homolog and its clinicopathological significance in benign and malignant lesion of gallbladder]. Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2008 Jul;33(7):618-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Expression of enhancer of zesle homolog 2 and phosphatase and tension homolog and its clinicopathological significance in benign and malignant lesion of gallbladder].
  • OBJECTIVE: To examine the expressive level of enhancer of zesle homolog 2 (EZH2) and phosphatase and tension homolog (PTEN), and to explore its clinicopathological significance in benign and malignant lesion of gallbladder.
  • METHODS: EnVision immunohistochemical method was used to detect the expressive levels of EZH2 and PTEN in routinely paraffin-embedded sections in the resected specimens of gallbladder adenocarcinoma (n = 108), peritumoral tissues (n = 46), adenomatous polyp(n = 15), and chronic cholecystitis (n = 35).
  • RESULTS: The positive rate of EZH2 was significantly higher in gallbladder adenocarcinoma than that in peritumoral tissues (chi(2) = 24.49, P < 0.01), adenomatous polyp(chi(2) = 11.68, P < 0.01), and chronic cholecystitis (chi(2) = 31.62, P < 0.01).
  • The benign lesions in the positive cases of EZH2 and (or) the negative ones of PTEN showed the moderately- or severely- atypical hyperplasia of gallbladder epithelium.
  • The positive rate of PTEN was significantly lower in gallbladder adenocarcinoma than that in peritumoral tissues(n = 20.20, P < 0.01), adenomatous polyp(chi(2)=10.81, P<0.01), and chronic cholecystitis (n = 29.83, P < 0.01).The positive rates of EZH2 were significantly lower in the highly-differentiated adenocarcinoma, the maximal diameter of mass < 2 cm, non-metastasis of lymphnodes, and non-infiltration of regional tissues than those in the moderately or low-differentiated adenocarcinoma, the maximal diameter > or = 2 cm, metastasis of lymphnode, and infiltration of regional tissues (P < 0.05 or P < 0.01).
  • High inconsistency was found between the expression of EZH2 and PTEN in gallbladder adenocarcinoma (P < 0.05).
  • CONCLUSION: Expression of EZH2 and/or PTEN might be important biological markers in the carcinogenesis, progression, biological behaviors and prognosis of gallbladder adenocarcinoma.
  • [MeSH-major] DNA-Binding Proteins / biosynthesis. Gallbladder Neoplasms / genetics. PTEN Phosphohydrolase / biosynthesis. Transcription Factors / biosynthesis
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Adult. Biomarkers, Tumor. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Middle Aged. Polycomb Repressive Complex 2. Prognosis

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  • (PMID = 18667776.001).
  • [ISSN] 1672-7347
  • [Journal-full-title] Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
  • [ISO-abbreviation] Zhong Nan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Transcription Factors; EC 2.1.1.43 / EZH2 protein, human; EC 2.1.1.43 / Polycomb Repressive Complex 2; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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93. Duffy A, Capanu M, Abou-Alfa GK, Huitzil D, Jarnagin W, Fong Y, D'Angelica M, Dematteo RP, Blumgart LH, O'Reilly EM: Gallbladder cancer (GBC): 10-year experience at Memorial Sloan-Kettering Cancer Centre (MSKCC). J Surg Oncol; 2008 Dec 1;98(7):485-9
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  • [Title] Gallbladder cancer (GBC): 10-year experience at Memorial Sloan-Kettering Cancer Centre (MSKCC).
  • BACKGROUND: The incidence of gallbladder cancer (GBC) in the US is 1.2/100,000.
  • METHODS: A retrospective analysis of patients referred to MSKCC with a diagnosis of GBC between January 1995 and December 2005 was performed.
  • Patients were identified from the MSKCC cancer registry.
  • Date of diagnosis was defined as date of surgery or biopsy.
  • Pathology: 88% adenocarcinoma, 4% squamous, 3% neuroendocrine, 2% sarcoma.
  • [MeSH-major] Gallbladder Neoplasms / mortality. Gallbladder Neoplasms / therapy

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18802958.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; B76N6SBZ8R / gemcitabine; U3P01618RT / Fluorouracil
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94. Ragazzi M, Carbonara C, Rosai J: Nonneoplastic signet-ring cells in the gallbladder and uterine cervix. A potential source of overdiagnosis. Hum Pathol; 2009 Mar;40(3):326-31
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  • [Title] Nonneoplastic signet-ring cells in the gallbladder and uterine cervix. A potential source of overdiagnosis.
  • We describe 3 cases of nonneoplastic signet-ring cell change in ulcerated mucosa, 2 of them in the gallbladder and 1 in an endocervical polyp.
  • In the gallbladder cases, there were focal collections of signet-ring cells both on the mucosal surface and within the lumen of tubules, whereas in the endocervical polyp, the signet-ring cell aggregates were entirely confined to the mucosal surface.
  • A review of the literature disclosed only other 2 previously reported cases of benign signet-ring cell changes in the gallbladder and none--to the best of our knowledge--in an endocervical polyp.
  • Awareness of this phenomenon is of importance to avoid a potential overdiagnosis of signet-ring cell adenocarcinoma.
  • [MeSH-major] Carcinoma, Signet Ring Cell / diagnosis. Cervix Uteri / pathology. Diagnostic Errors / prevention & control. Gallbladder Diseases / pathology. Polyps / pathology. Uterine Cervical Diseases / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Hyperplasia. Keratins / metabolism. Male. Middle Aged. Mucous Membrane / pathology. Ulcer / pathology. Young Adult


95. Matheus AS, Jukemura J, Montagnini AL, Kunitake T, Patzina RA, da Cunha JE: Synchronous adenocarcinoma of the major and minor duodenal papilla. J Gastrointest Surg; 2008 Jul;12(7):1301-3
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  • [Title] Synchronous adenocarcinoma of the major and minor duodenal papilla.
  • Contrast-enhanced computed tomography and abdominal ultrasound showed slight dilatation of the biliary tree and gallbladder without calculi.
  • First endoscopically biopsy diagnosed no tumor, and a second biopsy diagnosed as papillary adenocarcinoma.
  • Gross examination showed two tumors seen as prolapsed nodules growing isolated from the minor and major duodenal papillae measuring 1.5 and 1.0 cm, respectively, both covered by duodenal mucosa and the histologic study of both lesions demonstrated a moderately differentiated tubular adenocarcinoma, which invaded duodenal wall.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater. Common Bile Duct Neoplasms / pathology. Neoplasms, Multiple Primary. Pancreatic Ducts. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Endoscopy, Gastrointestinal / methods. Female. Follow-Up Studies. Humans. Middle Aged. Pancreaticoduodenectomy / methods

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  • (PMID = 17876672.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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96. Ricks AM, Han LY, Rashid A, Frumovitz M: Gallbladder carcinoma presenting as a pelvic mass with elevated serum testosterone: a case report. J Reprod Med; 2009 Apr;54(4):259-60
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  • [Title] Gallbladder carcinoma presenting as a pelvic mass with elevated serum testosterone: a case report.
  • Preoperative clinical diagnosis was suggestive of Sertoli-Leydig tumor.
  • Final diagnosis was stage IV primary gallbladder malignancy with metastases to the ovaries.
  • In women with complex pelvic masses, metastasis should be considered as part of the differential diagnosis.
  • [MeSH-major] Adenocarcinoma / diagnosis. Gallbladder Neoplasms / diagnosis. Testosterone / blood
  • [MeSH-minor] Abdominal Pain. Antineoplastic Agents / administration & dosage. CA-125 Antigen / blood. Cholecystectomy. Cisplatin / administration & dosage. Deoxycytidine / administration & dosage. Deoxycytidine / analogs & derivatives. Diagnosis, Differential. Fallopian Tubes / surgery. Fatal Outcome. Female. Humans. Hysterectomy. Middle Aged. Neoplasm Staging. Ovarian Neoplasms / secondary. Ovariectomy. Tomography, X-Ray Computed. Ultrasonography

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  • (PMID = 19438170.001).
  • [ISSN] 0024-7758
  • [Journal-full-title] The Journal of reproductive medicine
  • [ISO-abbreviation] J Reprod Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / CA-125 Antigen; 0W860991D6 / Deoxycytidine; 3XMK78S47O / Testosterone; B76N6SBZ8R / gemcitabine; Q20Q21Q62J / Cisplatin
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97. Hellenthal NJ, Stewart GS, Cambio AJ, Delair SM: Renal cell carcinoma metastatic to gallbladder: a survival advantage to simultaneous nephrectomy and cholecystectomy. Int Urol Nephrol; 2007;39(2):377-9
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  • [Title] Renal cell carcinoma metastatic to gallbladder: a survival advantage to simultaneous nephrectomy and cholecystectomy.
  • Renal cell carcinoma is a relatively uncommon cancer.
  • Patients presenting with a renal adenocarcinoma are often found to have evidence of metastatic disease at the time of diagnosis.
  • Herein, we describe the case of a 39-year-old male with renal cell carcinoma and a synchronous metastatic focus to the gallbladder.
  • [MeSH-major] Carcinoma, Renal Cell / secondary. Carcinoma, Renal Cell / surgery. Cholecystectomy. Gallbladder Neoplasms / secondary. Gallbladder Neoplasms / surgery. Kidney Neoplasms / pathology. Kidney Neoplasms / surgery. Nephrectomy

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  • (PMID = 17308877.001).
  • [ISSN] 0301-1623
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Hungary
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98. Ikeda T, Ohgaki K, Miura M, Aishima S, Shimizu T, Maehara Y: Granulocyte-colony stimulating factor-producing gallbladder cancer without recurrence more than 2 years after resection: report of a case. Surg Today; 2005;35(7):590-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granulocyte-colony stimulating factor-producing gallbladder cancer without recurrence more than 2 years after resection: report of a case.
  • Patients with gallbladder carcinoma rarely have remarkable granulocytosis.
  • Although surgical resection is the most effective treatment, patients with gallbladder carcinoma generally have a very poor prognosis.
  • We report a case of a rapidly growing gallbladder tumor associated with remarkable granulocytosis in a patient who has survived without recurrence for more than 2 years since undergoing resection.
  • A histological diagnosis of moderately differentiated gallbladder carcinoma with sarcomatous change invading the hepatic parenchyma was confirmed.
  • An immunohistochemical examination using polyclonal antibody against G-CSF was performed to stain the tumor cells, which confirmed the diagnosis of a G-CSF-producing tumor.
  • [MeSH-major] Adenocarcinoma / metabolism. Gallbladder Neoplasms / metabolism. Granulocyte Colony-Stimulating Factor / biosynthesis

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  • (PMID = 15976958.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 143011-72-7 / Granulocyte Colony-Stimulating Factor
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99. Khunamornpong S, Lerwill MF, Siriaunkgul S, Suprasert P, Pojchamarnwiputh S, Chiangmai WN, Young RH: Carcinoma of extrahepatic bile ducts and gallbladder metastatic to the ovary: a report of 16 cases. Int J Gynecol Pathol; 2008 Jul;27(3):366-79
MedlinePlus Health Information. consumer health - Ovarian Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoma of extrahepatic bile ducts and gallbladder metastatic to the ovary: a report of 16 cases.
  • Information on ovarian metastasis of carcinoma of the extrahepatic bile ducts and gallbladder is limited.
  • Sixteen examples are reported; 3 primary tumors were hilar cholangiocarcinomas, 5 common bile duct carcinomas, and 8 gallbladder carcinomas.
  • Signet ring cells were present in sufficient quantity for a diagnosis of Krukenberg tumor in four tumors.
  • Nonmucinous carcinomatous components included adenocarcinoma with high-grade endometrioid-like morphology in 2 cases, papillary adenocarcinoma simulating mixed müllerian epithelial adenocarcinoma in 1, and undifferentiated carcinoma in 2.
  • Although the diagnosis of a metastatic tumor to the ovary is possible in most of the cases based on standard diagnostic criteria, problems in the differential diagnosis may be posed by morphologic patterns that overlap strikingly with primary ovarian neoplasms, benign, borderline, and malignant, as discussed herein.
  • [MeSH-major] Adenocarcinoma / pathology. Bile Duct Neoplasms / pathology. Gallbladder Neoplasms / pathology. Ovarian Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Bile Duct Cancer.
  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
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  • (PMID = 18580314.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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100. Chianakwana GU, Okafor PI, Anyanwu SN: Carcinoma of the gallbladder at the Nnamdi Azikiwe University Teaching Hospital--a 5-year retrospective study. Niger J Clin Pract; 2005 Jun;8(1):10-3
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoma of the gallbladder at the Nnamdi Azikiwe University Teaching Hospital--a 5-year retrospective study.
  • BACKGROUND: Carcinoma of the gallbladder is often missed because of the low index of suspicion.
  • AIMS AND OBJECTIVES: To review the incidence, pattern and outcome of carcinoma of the gallbladder in our center and to highlight the need for early diagnosis.
  • DESIGN: Retrospective survey of all cases of carcinoma of the gallbladder.
  • PATIENTS AND METHODS: Patients who had histologically confirmed carcinoma in the general surgical units of the Nnamdi Azikiwe University Teaching Hospital over a 5-year period were reviewed and, from their case notes, the following information on sex, age, mode of presentation, time of diagnosis, stage of disease, treatment given and outcome were extracted.
  • RESULTS: Twenty-one cases of gallbladder carcinoma were seen out of a total of 692 cases of different types of cancers seen in the general surgical units, giving an incidence of 3.04%.
  • The outcome was good in patients who presented with features of cholecystitis but who turned out to be cases of early carcinoma of the gallbladder because after five years of follow-up, none of them has shown any features of recurrence.
  • CONCLUSIONS: Carcinoma of the gallbladder may present as cholecystitis.
  • Early presentation to hospital by patients would avert delay and improve early diagnosis, early treatment, and better outcome.
  • [MeSH-major] Adenocarcinoma / epidemiology. Gallbladder Neoplasms / epidemiology. Hospitals, University / statistics & numerical data

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  • (PMID = 16392449.001).
  • [ISSN] 1119-3077
  • [Journal-full-title] Nigerian journal of clinical practice
  • [ISO-abbreviation] Niger J Clin Pract
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Nigeria
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