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1. Zhu JB, Li B, Sun XL, Li LQ, Shi JT, An YZ: [Clinical and pathological features of 273 cases of lacrimal epithelial tumors]. Zhonghua Yan Ke Za Zhi; 2004 Apr;40(4):220-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: Pleomorphic adenoma was the most common tumor in epithelial tumors of lacrimal gland, followed by adenoid cystic carcinoma, pleomorphic adenocarcinoma and adenocarcinoma.
  • It is important to have a correct clinical diagnosis, to select the proper surgical method, drug treatment and postoperative management based on the pathological diagnosis, which can result in a decrease of recurrence rate.
  • [MeSH-major] Eye Neoplasms / pathology. Lacrimal Apparatus / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adenoma, Pleomorphic / pathology. Adolescent. Adult. Aged. Carcinoma, Adenoid Cystic / pathology. Child. China. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies


2. Kaur H, Buettner H, Salomao DR, Marks RS: Transcleral orbital invasion by a radiation and chemotherapy-resistant choroidal metastasis of a pulmonary adenocarcinoma. Am J Ophthalmol; 2007 Feb;143(2):369-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transcleral orbital invasion by a radiation and chemotherapy-resistant choroidal metastasis of a pulmonary adenocarcinoma.
  • PURPOSE: To report transcleral orbital invasion by a radiation- and chemotherapy-resistant choroidal metastasis of a pulmonary adenocarcinoma.
  • METHODS: A 51-year-old female was found to have choroidal metastasis from a previously unknown primary pulmonary adenocarcinoma.
  • RESULTS: A transvitreal aspiration biopsy of the choroidal lesion confirmed the diagnosis of metastatic pulmonary adenocarcinoma.
  • Histopathology revealed invasion through scleral emissary channels to the retrobulbar tissue and through the optic nerve substance itself.
  • CONCLUSIONS: Despite appropriate external beam radiation therapy (EBRT) and chemotherapy, pulmonary adenocarcinoma metastases to the choroid can continue to grow and may invade the orbit transclerally.
  • [MeSH-major] Adenocarcinoma / secondary. Choroid Neoplasms / secondary. Lung Neoplasms / pathology. Orbital Neoplasms / pathology. Sclera / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carboplatin / administration & dosage. Chemotherapy, Adjuvant. Deoxycytidine / administration & dosage. Deoxycytidine / analogs & derivatives. Drug Resistance. Eye Enucleation. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Neoplasm Invasiveness. Radiation Tolerance. Radiotherapy Dosage

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  • (PMID = 17258542.001).
  • [ISSN] 0002-9394
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine; BG3F62OND5 / Carboplatin
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3. Sahin A, Kiratli H: Choroidal metastasis as a first sign of recurrence in a patient with gastric adenocarcinoma. Can J Ophthalmol; 2007 Apr;42(2):331-2
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  • [Title] Choroidal metastasis as a first sign of recurrence in a patient with gastric adenocarcinoma.
  • CASE REPORT: A 40-year-old man with a history of gastric adenocarcinoma presented with progressive visual loss in his right eye.
  • COMMENTS: This patient represents a rare occurrence of metastatic gastric adenocarcinoma to the choroid and optic nerve, developing as a first sign of systemic recurrence.

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  • (PMID = 17392868.001).
  • [ISSN] 0008-4182
  • [Journal-full-title] Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
  • [ISO-abbreviation] Can. J. Ophthalmol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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4. Read RW, Green RL, Rao NA: Metastatic adenocarcinoma with rupture through the Bruch membrane simulating a choroidal melanoma. Am J Ophthalmol; 2001 Dec;132(6):943-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic adenocarcinoma with rupture through the Bruch membrane simulating a choroidal melanoma.
  • PURPOSE: To report a case of adenocarcinoma metastatic to the choroid with rupture through the Bruch membrane, thus, simulating a choroidal melanoma.
  • Evaluation in a university-based clinic, including a complete eye examination, fluorescein angiography, and ultrasonography; oncological evaluation; and eventual enucleation with histopathological study, including immunohistochemical stains.
  • RESULTS: A 62-year-old Hispanic female presented with visual loss, right eye, of short duration because of a choroidal mass with retinal detachment.
  • Severe pain necessitated enucleation, RE, and histopathology of the choroidal mass demonstrated an adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Brain Neoplasms / pathology. Bruch Membrane / pathology. Choroid Neoplasms / secondary. Melanoma / diagnosis. Retinal Detachment / diagnosis
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Carcinoma, Non-Small-Cell Lung / diagnosis. Carcinoma, Non-Small-Cell Lung / drug therapy. Diagnosis, Differential. Eye Enucleation. Female. Fluorescein Angiography. Humans. Immunoenzyme Techniques. Lung Neoplasms / diagnosis. Lung Neoplasms / drug therapy. Middle Aged. Pain / diagnosis. Rupture, Spontaneous

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  • (PMID = 11730672.001).
  • [ISSN] 0002-9394
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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5. Rendón-Huerta E, Teresa F, Teresa GM, Xochitl GS, Georgina AF, Veronica ZZ, Montaño LF: Distribution and expression pattern of claudins 6, 7, and 9 in diffuse- and intestinal-type gastric adenocarcinomas. J Gastrointest Cancer; 2010 Mar;41(1):52-9
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  • [Title] Distribution and expression pattern of claudins 6, 7, and 9 in diffuse- and intestinal-type gastric adenocarcinomas.
  • INTRODUCTION: Intestinal- and diffuse-type gastric adenocarcinomas differ in clinical outcome and genetic profile.
  • Our aim was to find specific claudin markers for each type.
  • METHODS: Fifty paraffin-embedded tissue blocks of diffuse- and intestinal-type gastric adenocarcinomas and fresh gastric biopsies obtained endoscopically from 20 patients with a presumptive diagnosis of gastric cancer were analyzed.
  • Claudin-7 was expressed mainly in the diffuse-type whereas claudin-9 was mainly found in the apical membrane of the gland cells in the intestinal-type.
  • Strong claudin-9 expression was associated with higher mortality rate (66%) in the diffuse type vs the intestinal type (25%) after a 2-year follow-up.
  • CONCLUSION: Claudins 6, 7, and 9 expressions are closely related to gastric carcinogenesis, and their detection is a useful prognostic marker in "intestinal-" and "diffuse-type" gastric adenocarcinomas.
  • [MeSH-major] Adenocarcinoma / metabolism. Membrane Proteins / biosynthesis. Stomach Neoplasms / metabolism

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  • (PMID = 19960275.001).
  • [ISSN] 1941-6636
  • [Journal-full-title] Journal of gastrointestinal cancer
  • [ISO-abbreviation] J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CLDN7 protein, human; 0 / CLDN9 protein, human; 0 / Claudins; 0 / Membrane Proteins; 0 / claudin 6
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