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1. Miyashita T, Ohta T, Fujimura T, Ninomiya I, Fushida S, Hattori T, Miwa K: Duodenal juice stimulates oesophageal stem cells to induce Barrett's oesophagus and oesophageal adenocarcinoma in rats. Oncol Rep; 2006 Jun;15(6):1469-75
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  • [Title] Duodenal juice stimulates oesophageal stem cells to induce Barrett's oesophagus and oesophageal adenocarcinoma in rats.
  • the present study was performed to examine the sequential process of the development of Barrett's oesophagus (BE) and oesophageal adenocarcinoma (ADC) induced by duodeno-oesophageal reflux (DER) in rats.
  • [MeSH-major] Adenocarcinoma / etiology. Barrett Esophagus / etiology. Duodenogastric Reflux / complications. Duodenum / secretion. Esophageal Neoplasms / etiology. Esophagus / pathology. Gastroesophageal Reflux / complications. Stem Cells / pathology

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  • (PMID = 16685381.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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2. Monira P, Koyama Y, Fukutomi R, Yasui K, Isemura M, Yokogoshi H: Effects of Japanese mistletoe lectin on cytokine gene expression in human colonic carcinoma cells and in the mouse intestine. Biomed Res; 2009 Oct;30(5):303-9
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  • [Title] Effects of Japanese mistletoe lectin on cytokine gene expression in human colonic carcinoma cells and in the mouse intestine.
  • In the present study, we examined the effects of ML-J on cytokine gene expression in human colon adenocarcinoma Caco-2 cells and in the mouse intestine.
  • The results of reverse transcription-polymerase chain reaction and quantitative real-time polymerase chain reaction indicated that ML-J caused an upregulation of the gene expression of the proinflammatory cytokines interleukin (IL)-8, tumor necrosis factor-alpha (TNF-alpha) and IL-6 in Caco-2 cells and TNF-alpha and IL-6 in the duodenum.
  • This study provides the first example to show that a perorally administered plant lectin affects gene expression in the duodenum.

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  • (PMID = 19887727.001).
  • [ISSN] 1880-313X
  • [Journal-full-title] Biomedical research (Tokyo, Japan)
  • [ISO-abbreviation] Biomed. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Cytokines; 0 / Plant Lectins
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3. Rivasi F, Pampiglione S, Boldorini R, Cardinale L: Histopathology of gastric and duodenal Strongyloides stercoralis locations in fifteen immunocompromised subjects. Arch Pathol Lab Med; 2006 Dec;130(12):1792-8
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  • [Title] Histopathology of gastric and duodenal Strongyloides stercoralis locations in fifteen immunocompromised subjects.
  • OBJECTIVE: To determine the histopathologic alterations of the gastric and duodenal mucosa associated with the presence of Strongyloides stercoralis parasites.
  • DESIGN: Fifteen cases of strongyloidiasis were observed in immunocompromised patients during a recent 6-year period in Italy. S. stercoralis was found histologically in gastric biopsies (10 cases), in a gastrectomy (1 case), and in duodenal biopsies (9 cases).
  • In 5 cases the parasite was present both in gastric and duodenal biopsies.
  • Four patients were affected by lymphoma, 2 by multiple myeloma, 2 by gastric carcinoma, 1 by chronic myeloid leukemia, 1 by sideroblastic anemia, 1 by colorectal adenocarcinoma, 1 by chronic idiopathic myelofibrosis, 1 by chronic gastritis, 1 by gastric ulcers, and 1 by rheumatoid arthritis in corticosteroid therapy.
  • All the parasites were located in the gastric and/or the duodenal crypts.
  • CONCLUSIONS: Histologic diagnosis of strongyloidiasis must be taken into consideration when examining both gastric and duodenal biopsies in immunocompromised patients, to avoid the development of an overwhelming infection of the parasite, which is dangerous for the life of the patient.
  • [MeSH-major] Duodenal Diseases / pathology. Immunocompromised Host. Stomach Diseases / pathology. Strongyloides stercoralis / isolation & purification. Strongyloidiasis / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Animals. Biopsy. Duodenum / parasitology. Duodenum / pathology. Female. Humans. Life Cycle Stages. Male. Middle Aged. Stomach / parasitology. Stomach / pathology

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  • (PMID = 17149952.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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4. Beger HG, Gansauge F, Siech M, Schwarz M, Poch B: Duodenum-preserving total pancreatic head resection for cystic neoplastic lesions in the head of the pancreas. J Hepatobiliary Pancreat Surg; 2008;15(2):149-56
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  • [Title] Duodenum-preserving total pancreatic head resection for cystic neoplastic lesions in the head of the pancreas.
  • Duodenum-preserving pancreatic head resection with segmental resection of the duodenum has been introduced for the surgical treatment of inflammatory and neoplastic lesions.
  • METHODS: Duodenum-preserving total pancreatic head resection (DPPHRt) with segmental resection of the duodenum (SD) was performed in eight patients, five with intraductal papillary mucinous neoplasm (IPMN), two with mucinous cystic neoplasm (MCN), and one with cystic endocrine neoplasm (EN).
  • RESULTS: Eight patients had a DPPHRt with SD resection, two patients had a resection of the uncinate process including segmental resection of the inferior duodenal segment, and one patient had a duodenum-and spleen-preserving total pancreatectomy.
  • CONCLUSIONS: Duodenum-preserving total pancreatic head resection for IPMN, MCN, serous cystadenoma (SCA), and cystic EN lesions is a safe and beneficial surgical procedure.
  • Segmental resection of the duodenum was applied for an oncologically complete resection.
  • [MeSH-major] Adenocarcinoma / surgery. Cysts / surgery. Duodenum / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / surgery

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  • (PMID = 18392707.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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5. Brosens LA, Iacobuzio-Donahue CA, Keller JJ, Hustinx SR, Carvalho R, Morsink FH, Hylind LM, Offerhaus GJ, Giardiello FM, Goggins M: Increased cyclooxygenase-2 expression in duodenal compared with colonic tissues in familial adenomatous polyposis and relationship to the -765G -> C COX-2 polymorphism. Clin Cancer Res; 2005 Jun 1;11(11):4090-6
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  • [Title] Increased cyclooxygenase-2 expression in duodenal compared with colonic tissues in familial adenomatous polyposis and relationship to the -765G -> C COX-2 polymorphism.
  • As a result, duodenal adenocarcinoma has become a leading cause of death in patients with FAP.
  • Cyclooxygenase 2 (COX-2) inhibition is effective against colorectal polyposis in FAP, but is less effective in treating duodenal polyps.
  • We compared the expression of COX-2 in duodenal and colorectal adenomas from patients with FAP and from patients with sporadic neoplasms and correlated expression to a COX-2 promoter polymorphism (-765G/-->C) that is reported to influence COX-2 expression.
  • METHODS: The study population included 36 FAP patients with colonic adenomas, 22 FAP patients with duodenal adenomas, 22 patients with sporadic duodenal adenomas, and 17 patients with sporadic duodenal adenocarcinoma.
  • RESULTS: Among patients with FAP, histologically normal duodenal mucosa showed higher COX-2 expression than normal colonic mucosa (P < 0.02), and duodenal adenomas had higher COX-2 expression than colonic adenomas (P </= 0.01).
  • In addition, the normal duodenum of patients with FAP showed higher COX-2 expression than the normal duodenal mucosa of patients with sporadic adenomas (P < 0.05).
  • CONCLUSIONS: High COX-2 expression in the normal and adenomatous duodenal mucosa of patients with FAP may explain the poorer response of these neoplasms to chemoprevention with COX-2 inhibitors.
  • [MeSH-major] Adenoma / pathology. Adenomatous Polyposis Coli / pathology. Colonic Neoplasms / pathology. Duodenal Neoplasms / pathology. Polymorphism, Single Nucleotide. Prostaglandin-Endoperoxide Synthases / genetics

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  • (PMID = 15930344.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / PHS HHS / / 51085; United States / PHS HHS / / 63721; United States / NCI NIH HHS / CA / CA 53801; United States / NCI NIH HHS / CA / P50 CA 93-16; United States / NCI NIH HHS / CA / P50 CA62924
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Proteins; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases
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6. Soulsby R, Leung E, Williams N: Malignant colo-duodenal fistula; case report and review of the literature. World J Surg Oncol; 2006;4:86
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  • [Title] Malignant colo-duodenal fistula; case report and review of the literature.
  • BACKGROUND: Colo-duodenal fistula is a rare complication of malignant and inflammatory bowel disease.
  • Cases with malignant colo-duodenal fistulae can present with symptoms from the primary, from the fistula or from metastatic disease.
  • CASE PRESENTATION: We present an unusual case of colorectal carcinoma, where a 65 year old male patient presented with diarrhoea and vomiting secondary to a malignant colo-duodenal fistula near the hepatic flexure.
  • Adenocarcinoma was confirmed on histology from a biopsy obtained during the patient's oesophageogastroduodenoscopy, and the fistula was demonstrated in his barium enema.
  • Staging computed tomography showed a locally advanced carcinoma of the proximal transverse colon, with a fistula to the duodenum and regional lymphadenopathy.
  • Colo-duodenal fistulae from colonic primaries are rare but early diagnosis may allow curative surgery.

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  • [Cites] Surg Today. 1999;29(9):906-10 [10489134.001]
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  • (PMID = 17147825.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1698919
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7. Badía Bartolomé C, Díaz Formoso FJ, Rodríguez Falcón R, Marchena Gómez J: [Groove pancreatitis and its differential diagnosis with pancreatic adenocarcinoma]. Gastroenterol Hepatol; 2009 Jan;32(1):22-8
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  • [Title] [Groove pancreatitis and its differential diagnosis with pancreatic adenocarcinoma].
  • [Transliterated title] Pancreatitis del surco y su diagnóstico diferencial con el adenocarcinoma de páncreas.
  • We analyzed the clinical, radiographic and histologic characteristics, as well as the difficulties that arose in the differential diagnosis between groove pancreatitis (a benign entity consisting of a segmental form of chronic pancreatitis occurring as a sheet-like scar in the area of pancreatoduodenal groove) and adenocarcinoma of the pancreas.
  • To this end, four cases with abnormalities in the groove area were retrospectively reviewed, three with groove pancreatitis, and one with adenocarcinoma of the pancreas.
  • [MeSH-major] Adenocarcinoma / diagnosis. Duodenitis / diagnosis. Pancreatic Neoplasms / diagnosis. Pancreatitis / diagnosis
  • [MeSH-minor] Adult. Aged. Biopsy, Fine-Needle. Cholangiopancreatography, Endoscopic Retrograde. Cholangiopancreatography, Magnetic Resonance. Cholelithiasis / complications. Cholelithiasis / diagnosis. Chronic Disease. Diagnosis, Differential. Duodenum / pathology. Fatal Outcome. Humans. Intestinal Mucosa / pathology. Magnetic Resonance Imaging. Male. Middle Aged. Pancreaticoduodenectomy. Pancreatitis, Alcoholic / complications. Retrospective Studies

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  • [CommentIn] Gastroenterol Hepatol. 2009 Nov;32(9):662-3 [19525034.001]
  • (PMID = 19174095.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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8. Lapikov IA, Mogilenko DA, Dizhe EB, Ignatovich IA, Orlov SV, Perevozchikov AP: [Ap1-like cis-elements in 5'-regulatory region of human apolipoprotein A-I gene]. Mol Biol (Mosk); 2008 Mar-Apr;42(2):295-305
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  • The functional role of 5'-apoA-I regions containing Ap1-like sites was studied in cotransfection experiments of HepG2 cells (synthesize endogenous ApoA-I), human duodenum adenocarcinoma Hutu80 cells (do not synthesize endogenous ApoA-I), human neuroblastoma SK-N-SH cells (do not synthesize endogenous A-I) with expression vectors of c-jun and mekk1 genes.

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  • (PMID = 18610838.001).
  • [ISSN] 0026-8984
  • [Journal-full-title] Molekuliarnaia biologiia
  • [ISO-abbreviation] Mol. Biol. (Mosk.)
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / ATF2 protein, human; 0 / Activating Transcription Factor 2; 0 / Apolipoprotein A-I; 0 / Proto-Oncogene Proteins c-jun; 0 / Transcription Factor AP-1
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9. Chen JL, Mok KT, Tseng HH, Wang BW, Liu SI, Chen CW: Duodenal angiosarcoma: an unusual cause of severe gastrointestinal bleeding. J Chin Med Assoc; 2007 Aug;70(8):352-5
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  • [Title] Duodenal angiosarcoma: an unusual cause of severe gastrointestinal bleeding.
  • Angiosarcoma is a rare soft-tissue neoplasm that occurs most often in the skin and the subcutaneous tissues but very rarely in the gastrointestinal tract.
  • Panendoscopy revealed multiple duodenal polypoid tumors, and initial biopsy specimen showed poorly differentiated adenocarcinoma.
  • The pathology was consistent with angiosarcoma of the duodenum.
  • [MeSH-major] Duodenal Neoplasms / complications. Gastrointestinal Hemorrhage / etiology. Hemangiosarcoma / complications

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  • (PMID = 17698438.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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10. Lee CC, Ng WK, Lin KW, Lai TW, Li SM: Adenocarcinoma of the duodenum. Hong Kong Med J; 2008 Feb;14(1):67-9
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  • [Title] Adenocarcinoma of the duodenum.
  • Adenocarcinoma of the duodenum is an exceedingly rare disorder.

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  • (PMID = 18239248.001).
  • [ISSN] 1024-2708
  • [Journal-full-title] Hong Kong medical journal = Xianggang yi xue za zhi
  • [ISO-abbreviation] Hong Kong Med J
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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11. Kovacs DJ, Berk T: Gastrointestinal bleeding of obscure origin undetected by multiple tests for fecal occult blood and diagnosed only by capsule endoscopy: a case report. J Am Board Fam Med; 2006 Nov-Dec;19(6):641-2
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  • We report the case of a middle-aged woman with gastrointestinal bleeding of obscure origin who had 9 stool specimens that tested negative for occult blood but was found to have adenocarcinoma of the distal duodenum on capsule endoscopy.
  • [MeSH-major] Capsule Endoscopy. Gastrointestinal Hemorrhage / diagnosis. Occult Blood

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  • (PMID = 17090799.001).
  • [ISSN] 1557-2625
  • [Journal-full-title] Journal of the American Board of Family Medicine : JABFM
  • [ISO-abbreviation] J Am Board Fam Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Zippi M, Traversa G, Masini A, De Felici I, Febbraro I, Mattei E, Pica R, Bertoldi I, Occhigrossi G: Placement of two overlapping uncovered metallic stents for malignant gastric outlet and duodenal obstruction due to colon cancer. Dig Liver Dis; 2006 Aug;38(8):612-4
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  • [Title] Placement of two overlapping uncovered metallic stents for malignant gastric outlet and duodenal obstruction due to colon cancer.
  • Malignant obstruction of the gastric outlet and duodenum is frequently due to extrinsic involvement by tumors from contiguous organs, in particular from pancreas and gallbladder.
  • The treatment of malignant gastroduodenal stenoses is difficult.
  • Many patients have advanced malignant disease and are too ill to undergo surgical approach.
  • We report a case in which self-expanding metallic stents were placed for stenoses of the gastric outlet and duodenum due to a colon cancer.
  • [MeSH-major] Adenocarcinoma / complications. Colonic Neoplasms / complications. Duodenal Obstruction / etiology. Duodenal Obstruction / surgery. Gastric Outlet Obstruction / etiology. Gastric Outlet Obstruction / surgery. Stents

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  • (PMID = 16828352.001).
  • [ISSN] 1590-8658
  • [Journal-full-title] Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • [ISO-abbreviation] Dig Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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13. Mann CD, Thomasset SC, Johnson NA, Garcea G, Neal CP, Dennison AR, Berry DP: Combined biliary and gastric bypass procedures as effective palliation for unresectable malignant disease. ANZ J Surg; 2009 Jun;79(6):471-5
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  • [Title] Combined biliary and gastric bypass procedures as effective palliation for unresectable malignant disease.
  • BACKGROUND: Although endoscopic treatment of jaundice is increasingly used in the palliation of unresectable malignant disease, surgical bypass still has a role to play in this setting.
  • This study aimed to reappraise the short-term and long-term results of combined biliary/gastric bypass (hepaticojejunostomy and gastrojejunostomy) as palliation for unresectable malignant disease.
  • METHODS: All patients undergoing simultaneous biliary and gastric bypass procedures for unresectable malignant disease between August 2000 and January 2006 were identified and outcomes reviewed.
  • RESULTS: One hundred and two patients underwent open surgical biliary drainage procedures for palliation of malignant disease.
  • Underlying malignant disease included pancreatic carcinoma (n = 88), duodenal adenocarcinoma (n = 6) and distal cholangiocarcinoma (n = 3).
  • [MeSH-major] Biliary Tract Surgical Procedures / methods. Duodenal Neoplasms / surgery. Gastric Bypass / adverse effects. Gastrostomy. Jejunostomy. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / surgery. Adult. Aged. Aged, 80 and over. Cholangiocarcinoma / surgery. Female. Follow-Up Studies. Humans. Male. Middle Aged. Palliative Care / methods. Survival Rate. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19566872.001).
  • [ISSN] 1445-2197
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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14. Bonfante P, Bianchi C, Magistrelli P, Bianco A, D'Ambra L, Berti S, Giaquinto D, Ansaldo V, Falco E: [Primary duodenal adenocarcinoma: report of three cases, prognostic factors and therapeutic approach]. G Chir; 2008 May;29(5):207-11
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  • [Title] [Primary duodenal adenocarcinoma: report of three cases, prognostic factors and therapeutic approach].
  • [Transliterated title] Adenocarcinoma primitivo del duodeno: tre casi clinici e considerazioni prognostico-terapeutiche.
  • Three cases of histologically proven primary non-ampullary adenocarcinoma of the duodenum, observed in our Department from 2001 to 2004, are described.
  • The cases were treated by pancreaticoduodenectomy, duodenal resection and transduodenal excision, respectively.
  • [MeSH-major] Adenocarcinoma / surgery. Duodenal Neoplasms / surgery

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  • (PMID = 18507955.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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15. Zins M, Loriau J, Boulay-Coletta I, Julles M, Petit E, Sauvanet A: [Postoperative imaging of the pancreas and duodenum]. J Radiol; 2009 Jul-Aug;90(7-8 Pt 2):918-36
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  • [Title] [Postoperative imaging of the pancreas and duodenum].
  • Pancreatic surgery is a frequent therapeutic approach for benign and malignant conditions.
  • [MeSH-major] Adenocarcinoma / surgery. Duodenum / surgery. Pancreas / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / methods. Postoperative Complications / radiography. Tomography, X-Ray Computed / methods

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  • (PMID = 19752831.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 57
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16. Jiménez Rodríguez RM, Suárez Artacho G, Morcillo J, Díaz Pavón JM, Morales Méndez S: [Adenocarcinoma in the fourth portion of duodenum in a patient with familial adenomatous polyposis]. Rev Esp Enferm Dig; 2007 Aug;99(8):477-8
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  • [Title] [Adenocarcinoma in the fourth portion of duodenum in a patient with familial adenomatous polyposis].
  • [Transliterated title] Adenocarcinoma de cuarta porción de duodeno en paciente con poliposis adenomatosa familiar.
  • [MeSH-major] Adenocarcinoma. Adenomatous Polyposis Coli. Duodenal Neoplasms. Neoplasms, Second Primary


17. Sabater L, Calvete J, Aparisi L, Cánovas R, Muñoz E, Añón R, Roselló S, Rodríguez E, Camps B, Alfonso R, Sala C, Sastre J, Cervantes A, Lledó S: [Pancreatic and periampullary tumors: morbidity, mortality, functional results and long-term survival]. Cir Esp; 2009 Sep;86(3):159-66
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  • [Transliterated title] Neoplasias de páncreas y periampulares: morbimortalidad, resultados funcionales y supervivencia a largo plazo.
  • Two and five-year survival rates in resected patients with pancreatic cancer were 42% and 9% respectively; in malignant ampulloma 71% and 53%; in mucinous adenocarcinomas 83% and 33%; in duodenal adenocarcinoma 100% and 75%; and in distal cholangiocarcinoma 50% and 50%.

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  • (PMID = 19616203.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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18. Nojima H, Shimizu H, Kimura F, Yoshidome H, Ohtsuka M, Kato A, Yoshitomi H, Furukawa K, Takeuchi D, Takayashiki T, Suda K, Takano S, Kuboki S, Kato M, Miyazaki M: [A resected case of non-invasive type of intraductal papillary mucinous carcinoma penetrating to the duodenum]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2376-8
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  • [Title] [A resected case of non-invasive type of intraductal papillary mucinous carcinoma penetrating to the duodenum].
  • Endoscopy revealed a fistula filled with mucin in the posterior wall of the duodenum.
  • Endoscopic ultrasonography revealed dilation of the pancreatic duct and also mural nodules in the pancreatic duct, ERP demonstrated a fistula from the pancreatic duct to the duodenum.
  • We performed pancreaticoduodenectomy for main-duct IPMN penetrating to the duodenum.
  • Furthermore, a cancer invasion to the duodenum was not detected.
  • These findings suggest that the increased pressure within the pancreatic duct caused a fistula to the duodenum.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoma, Pancreatic Ductal / pathology. Duodenal Diseases / etiology. Intestinal Fistula / etiology. Pancreatic Fistula / etiology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Aged. Duodenum / pathology. Humans. Male. Pancreaticoduodenectomy

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  • (PMID = 21224578.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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19. Ichimura T, Kondo S, Okamura K, Tanaka E, Hirano S: Total parenchymal pancreatectomy preserving the duodenum, choledochus and spleen for widespread intraductal papillary mucinous neoplasm: report of a case. Hepatogastroenterology; 2010 Jan-Feb;57(97):8-11
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  • [Title] Total parenchymal pancreatectomy preserving the duodenum, choledochus and spleen for widespread intraductal papillary mucinous neoplasm: report of a case.
  • For patients with benign or low malignant diseases of the pancreas, several organ-preserving surgical techniques of pancreatectomy have been presented for localized lesions.
  • We herein report a patient with widespread intraductal papillary mucinous neoplasm treated successfully with total parenchymal pancreatectomy.
  • A 73-year-old man was diagnosed as main duct intraductal papillary mucinous neoplasm.
  • We performed total parenchymal pancreatectomy, an initial surgical procedure in which almost all parenchyma of the pancreas was resected but the duodenum, the common bile duct and the spleen were preserved and no reconstruction was needed.
  • [MeSH-major] Adenocarcinoma, Mucinous / surgery. Carcinoma, Pancreatic Ductal / surgery. Pancreatectomy. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Aged. Common Bile Duct. Duodenum. Humans. Male. Spleen

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  • (PMID = 20422863.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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20. Liu ZF, Jiao SC, Yang JL, Dai GH: [Clinical research of 120 cases of primary small intestine malignant tumor]. Nan Fang Yi Ke Da Xue Xue Bao; 2010 Mar;30(3):602-4, 607
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  • [Title] [Clinical research of 120 cases of primary small intestine malignant tumor].
  • OBJECTIVE: To study the clinical and pathological features, diagnosis, therapy and prognosis of primary small intestine malignant tumor.
  • METHODS: A retrospective analysis was performed on the clinical data from the 120 cases of primary small intestine malignant tumor.
  • Most tumors originated in the duodenum (54.1%), and adenocarcinoma (55.8%) was the main pathological type.
  • CONCLUSION: Primary small intestine malignant tumors lack specific clinical manifestations and surgical resection should be performed as early as possible.
  • [MeSH-major] Adenocarcinoma. Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / surgery. Intestine, Small / pathology

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  • (PMID = 20335150.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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21. Alexander S, Bourke MJ, Williams SJ, Bailey A, Co J: EMR of large, sessile, sporadic nonampullary duodenal adenomas: technical aspects and long-term outcome (with videos). Gastrointest Endosc; 2009 Jan;69(1):66-73
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  • [Title] EMR of large, sessile, sporadic nonampullary duodenal adenomas: technical aspects and long-term outcome (with videos).
  • Few studies have, however, been published on the safety, efficacy, and technical aspects of EMR in the duodenum.
  • OBJECTIVE: Our purpose was to evaluate the efficacy and safety of EMR of large (>15 mm) duodenal adenomas.
  • PATIENTS: Patients with large (>15 mm) sporadic nonampullary duodenal adenomas managed by a standardized technique who were referred by other specialist endoscopists for endoscopic treatment.
  • METHODS: Five-year data from patients undergoing EMR for large duodenal adenomas were reviewed retrospectively.
  • Post-EMR histologic examination revealed mucosal adenocarcinoma in 1, low-grade tubulovillous adenoma (TVA) in 16, high- or focal high-grade TVA in 3 patients, and 1 with both high-grade TVA and carcinoid.
  • CONCLUSION: EMR for large sporadic nonampullary duodenal adenomas is a safe and effective technique.
  • [MeSH-major] Adenoma / surgery. Duodenal Neoplasms / surgery. Duodenoscopy / methods. Intestinal Mucosa / surgery. Neoplasm Invasiveness / pathology
  • [MeSH-minor] Aged. Cohort Studies. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Risk Assessment. Survival Rate. Time Factors. Treatment Outcome. Video-Assisted Surgery / methods

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  • (PMID = 18725157.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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22. Birbe R, Palazzo JP, Walters R, Weinberg D, Schulz S, Waldman SA: Guanylyl cyclase C is a marker of intestinal metaplasia, dysplasia, and adenocarcinoma of the gastrointestinal tract. Hum Pathol; 2005 Feb;36(2):170-9
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  • [Title] Guanylyl cyclase C is a marker of intestinal metaplasia, dysplasia, and adenocarcinoma of the gastrointestinal tract.
  • Guanylyl cyclase C protein was expressed by epithelial cells from the duodenum to the rectum, but not by those in normal esophagus and stomach.
  • [MeSH-major] Adenocarcinoma / enzymology. Gastrointestinal Neoplasms / enzymology. Gastrointestinal Tract / enzymology. Guanylate Cyclase / metabolism. Metaplasia / enzymology. Receptors, Peptide / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Humans. Immunoenzyme Techniques. Intestinal Mucosa / enzymology. Intestinal Mucosa / pathology. RNA, Messenger / metabolism. RNA, Neoplasm / analysis. Receptors, Guanylate Cyclase-Coupled. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 15754294.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA75123; United States / NCI NIH HHS / CA / CA79663; United States / NCI NIH HHS / CA / CA95026; United States / NCI NIH HHS / CA / R01 CA075123-06; United States / NIGMS NIH HHS / GM / R01 GM050290-05
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / Receptors, Peptide; EC 4.6.1.2 / Guanylate Cyclase; EC 4.6.1.2 / Receptors, Guanylate Cyclase-Coupled; EC 4.6.1.2 / enterotoxin receptor
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23. Adhikari RC, Tuladhar A, Shrestha S, Sharma SK: Deep-seated thoracic and abdominal lesions: usefulness of ultrasound guided fine needle aspiration cytology, a 3 year experience. Nepal Med Coll J; 2010 Mar;12(1):20-5
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  • The aim of this study was to evaluate the overall utility of ultrasonographic guided FNAC in the diagnosis of abdominal and thoracic lesions.
  • In 264 cases (82.5%), FNAC was diagnostic with commonest diagnosis being malignant neoplasm (70.0%).
  • In liver, Metastatic adenocarcinoma is the commonest tumor, while in lung; the commonest lesion is non-small cell carcinoma.
  • Benign neoplasm (3.1%) and non neoplastic lesion (9.4%) were also diagnosed by FNAC.
  • Rare sites like oesophagus and duodenum were also aspirated.
  • [MeSH-major] Neoplasms / diagnosis. Ultrasonography, Interventional

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  • (PMID = 20677604.001).
  • [Journal-full-title] Nepal Medical College journal : NMCJ
  • [ISO-abbreviation] Nepal Med Coll J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nepal
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24. Membrillo-Romero A, Hernández-Mondragón O, Blancas-Valencia JM: [Images of gastrointestinal endoscopy. Duodenal Adenocarcinoma (fourth segment)]. Rev Med Inst Mex Seguro Soc; 2006 May-Jun;44(3):256
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  • [Title] [Images of gastrointestinal endoscopy. Duodenal Adenocarcinoma (fourth segment)].
  • [Transliterated title] Imágenes de endoscopia gastrointestinal. Adenocarcinoma duodenal (cuarta porción).
  • [MeSH-major] Adenocarcinoma / diagnosis. Duodenal Neoplasms / diagnosis. Endoscopy, Gastrointestinal

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  • (PMID = 16870121.001).
  • [ISSN] 0443-5117
  • [Journal-full-title] Revista médica del Instituto Mexicano del Seguro Social
  • [ISO-abbreviation] Rev Med Inst Mex Seguro Soc
  • [Language] spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Mexico
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25. Moon YL, Ahn KY, Moon SP, Lim SC, Venkat G: Subscapularis muscle metastases of duodenal adenocarcinoma: a case report. J Shoulder Elbow Surg; 2010 Mar;19(2):e18-21
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  • [Title] Subscapularis muscle metastases of duodenal adenocarcinoma: a case report.

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  • (PMID = 19963402.001).
  • [ISSN] 1532-6500
  • [Journal-full-title] Journal of shoulder and elbow surgery
  • [ISO-abbreviation] J Shoulder Elbow Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Toll AD, Bibbo M: Identification of gastrointestinal contamination in endoscopic ultrasound-guided pancreatic fine needle aspiration. Acta Cytol; 2010 May-Jun;54(3):245-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To evaluate whether B72.3 and CEA could identify duodenal and gastric contamination in cell blocks of clinically proven cases of pancreatic ductal carcinoma, intraductal papillary mucinous neoplasm (IPMN) and mucinous cystic neoplasm (MCN).
  • STUDY DESIGN: Cell blocks of pancreatic fine needle aspirates from 19 ductal adenocarcinomas, 9 IPMNs, 5 MCNs, and 22 cases containing gastrointestinal epithelial contamination (GIC) (7 gastric, 15 duodenal) were stained with antibody to carcinoembryonic antigen (CEA) and B72.3.
  • It was never expressed in gastric contamination and was positive in 2/15 (13%) duodenal contaminants.
  • It was positive in 2/7 (28%) gastric and 7/15 (47%) duodenal contaminants.
  • A lack of CEA expression, however, can be used to identify both gastric and duodenal contamination.
  • [MeSH-major] Duodenum / pathology. Endosonography. Pancreatic Neoplasms / diagnosis. Stomach / pathology
  • [MeSH-minor] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / metabolism. Antibodies, Neoplasm / metabolism. Artifacts. Biomarkers / metabolism. Biopsy, Fine-Needle. Carcinoembryonic Antigen / metabolism. Carcinoma, Pancreatic Ductal / diagnosis. Carcinoma, Pancreatic Ductal / metabolism. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / metabolism. Diagnostic Errors / prevention & control. Humans

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  • (PMID = 20518405.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Neoplasm; 0 / B72.3 antibody; 0 / Biomarkers; 0 / Carcinoembryonic Antigen
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27. Asthana N, Mandich D, Ligato S: Esophageal polypoid dysplasia of gastric foveolar phenotype with focal intramucosal carcinoma associated with Barrett's esophagus. Am J Surg Pathol; 2008 Oct;32(10):1581-5
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  • In our opinion, this case represents a precursor lesion of an extremely well-differentiated adenocarcinoma of gastric foveolar phenotype that has been previously documented in the stomach and in the duodenum and that now for the first time we report in the esophagus in association with Barrett's intestinal metaplasia.
  • [MeSH-major] Adenocarcinoma / pathology. Barrett Esophagus / pathology. Esophageal Neoplasms / pathology. Esophagus / pathology. Precancerous Conditions / pathology


28. Yamamoto Y, Watanabe Y, Horiuchi A, Yoshida M, Yukumi S, Sato K, Nakagawa H, Sugishita H, Ishida N, Ishikawa M, Ishikawa K, Kawachi K: Adenoendocrine carcinoma of the accessory papilla of the duodenum: report of a case. Surg Today; 2009;39(5):425-9
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  • [Title] Adenoendocrine carcinoma of the accessory papilla of the duodenum: report of a case.
  • This report describes a very rare case of an adenoendocrine carcinoma of the accessory papilla of the duodenum.
  • Gastrointestinal endoscopy showed a protruding tumor with ulceration at the accessory papilla of the duodenum.
  • A biopsy revealed a small-cell carcinoma.
  • Microscopically, the tumor was a small-cell neuroendocrine carcinoma with adenomatous differentiation.
  • The final diagnosis was an adenoendocrine carcinoma with lymph node metastasis.
  • [MeSH-major] Adenocarcinoma, Papillary / diagnosis. Carcinoma, Neuroendocrine / diagnosis. Duodenal Neoplasms / diagnosis. Endocrine Glands / pathology

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  • (PMID = 19408082.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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29. Jerkic S, Rosewich H, Scharf JG, Perske C, Füzesi L, Wilichowski E, Gärtner J: Colorectal cancer in two pre-teenage siblings with familial adenomatous polyposis. Eur J Pediatr; 2005 May;164(5):306-10
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  • Familial adenomatous polyposis (FAP) is an autosomal dominant disorder that characteristically presents with colon cancer in early adult life.
  • Oesophago-gastric and duodenal endoscopy revealed that polyps had also developed in the duodenum.
  • The patient underwent a proctocolectomy and endoscopic duodenal mucosectomy.
  • The diagnosis of an adenocarcinoma of the colon and further adenomatous polyps with low-grade and high-grade dysplasia was confirmed by histology.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenomatous Polyposis Coli / diagnosis. Carcinoma / diagnosis. Colorectal Neoplasms / diagnosis. Siblings


31. Nonokuma M, Okazaki M, Higashibara H, Kimura S, Kora S, Urakawa H, Shinagawa Y, Osame A, Ueki T, Nakayama T: Successful embolization of pancreaticoduodenal artery pseudoaneurysm in a patient with common hepatic arterial occlusion after modified pancreatoduodenectomy with preservation of arteries in the head of pancreas. Hepatogastroenterology; 2009 Jan-Feb;56(89):245-8
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  • Pancreaticoduodenectomy (PD) with preservation of the arcade in the head of the pancreas was performed in a 73-year-old male with ampullary adenocarcinoma associated with occlusion of the common hepatic artery (CHA) in another hospital.
  • Celiac arteriogram showed complete occlusion of the CHA, posterior superior pancreaticoduodenal artery (PSPDA) pseudoaneurysm 1.7 cm in diameter and development of an enlarged tortuous dorsal pancreatic artery (DPA), posterior pancreatico-duodenal artery (PPDA), and gastroduodenal artery (GDA).
  • [MeSH-major] Adenocarcinoma, Papillary / therapy. Aneurysm, False / therapy. Arterial Occlusive Diseases / therapy. Duodenum / blood supply. Embolization, Therapeutic. Hepatic Artery. Pancreas / blood supply. Pancreatic Neoplasms / therapy

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  • (PMID = 19453067.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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32. Takahashi T, Ando T, Kabeshima Y, Kawakubo H, Shito M, Sugiura H, Omori T: Borderline cases between benignancy and malignancy of the duodenum diagnosed successfully by endoscopic submucosal dissection. Scand J Gastroenterol; 2009;44(11):1377-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Borderline cases between benignancy and malignancy of the duodenum diagnosed successfully by endoscopic submucosal dissection.
  • OBJECTIVE. Due to advances in endoscopic equipment, primary duodenal tumors are found more frequently than in the past.
  • We performed endoscopic submucosal dissection (ESD) to diagnose and treat four non-ampullary duodenal tumors.
  • CONCLUSIONS. Since tissue obtained from endoscopic biopsies can sometimes prove difficult for definitive histological diagnosis, ESD may play an important role in the management of cases appearing to border on malignancy.
  • In addition, ESD allows for minimally invasive treatment without sacrificing the possibility of cure for duodenal carcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma / diagnosis. Dissection / methods. Duodenal Neoplasms / diagnosis. Endoscopy, Gastrointestinal / methods. Intestinal Mucosa / pathology
  • [MeSH-minor] Aged. Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male

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  • (PMID = 19821793.001).
  • [ISSN] 1502-7708
  • [Journal-full-title] Scandinavian journal of gastroenterology
  • [ISO-abbreviation] Scand. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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33. Lee I, Lim JH, Choi D, Jang KT, Lee KT, Choi SH: Intraductal papillary mucinous tumors of the pancreas: branch duct tumor penetrating the stomach and duodenum. AJR Am J Roentgenol; 2006 Dec;187(6):W604-6
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  • [Title] Intraductal papillary mucinous tumors of the pancreas: branch duct tumor penetrating the stomach and duodenum.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoma, Papillary / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Duodenal Neoplasms / pathology. Humans. Male. Middle Aged. Neoplasm Invasiveness. Stomach Neoplasms / pathology

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  • (PMID = 17114512.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Monte MJ, Ballestero MR, Briz O, Perez MJ, Marin JJ: Proapoptotic effect on normal and tumor intestinal cells of cytostatic drugs with enterohepatic organotropism. J Pharmacol Exp Ther; 2005 Oct;315(1):24-35
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  • The proapoptotic effect of cisplatin bile acid derivatives Bamet-R2 [cis-diamminechloro-cholylglycinate-platinum(II)] and Bamet-UD2 [cis-diammine-bisursodeoxycholate-platinum(II)], developed to treat liver and intestinal tumors, was investigated in vitro using human enterohepatic cells HepG2 (hepatoblastoma), LS 174T (colon adenocarcinoma), and its cisplatin-resistant subline LS 174T/R.
  • The degree of necrosis (lactate dehydrogenase release) induced by these three drugs was small and similar in all cell types.
  • Oral administration of Bamet-UD2 to mice induced mild apoptosis in the small intestine (ileum > duodenum), which was not severe enough to modify its structure or function as determined by water absorption and glycocholic acid uptake by in situ perfused ileum.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Apoptosis / drug effects. Intestinal Neoplasms / drug therapy. Intestine, Small / drug effects. Organoplatinum Compounds / pharmacology. Ursodeoxycholic Acid / analogs & derivatives

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  • (PMID = 15985617.001).
  • [ISSN] 0022-3565
  • [Journal-full-title] The Journal of pharmacology and experimental therapeutics
  • [ISO-abbreviation] J. Pharmacol. Exp. Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Bamet-UD2; 0 / DNA Adducts; 0 / Organoplatinum Compounds; 0 / diamminebis(ursodeoxycholate(O,O'))platinum(II); 724L30Y2QR / Ursodeoxycholic Acid
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35. Aranha GV, Shoup M: Nonstandard pancreatic resections for unusual lesions. Am J Surg; 2005 Feb;189(2):223-8
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  • BACKGROUND: Pancreatic resections including pancreaticoduodenectomy and distal pancreatectomy are the standard of care for patients with malignant tumors of the pancreas.
  • RESULTS: Parenchymal-sparing surgeries including pancreatic enucleation, central pancreatectomy, splenic-preserving distal pancreatectomy, and duodenal-preserving pancreatic head resection are described.
  • [MeSH-major] Adenocarcinoma / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Duodenum / surgery. Humans. Spleen / surgery

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  • (PMID = 15720996.001).
  • [ISSN] 0002-9610
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 52
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36. Yamasaki T, Nebiki H, Sasaki E, Kurai O: Successful treatment of duodenal adenocarcinoma with multiple liver metastases by S-1 + irinotecan (CPT-11). Clin J Gastroenterol; 2009 Aug;2(4):287-290
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  • [Title] Successful treatment of duodenal adenocarcinoma with multiple liver metastases by S-1 + irinotecan (CPT-11).
  • Unresectable duodenal adenocarcinoma excluding the ampullary region is rare, and no standard chemotherapy has been defined for this disease.
  • Although S-1-based chemotherapy is widely administered for advanced gastric cancer, few reports have described advanced duodenal cancer treated with S-1-based chemotherapy.
  • We present herein a case of duodenal adenocarcinoma with liver metastases.
  • Gastroduodenal endoscopy revealed an ulcerative lesion on the upper wall of the duodenal bulb, and biopsy specimens showed well-differentiated adenocarcinoma.
  • S-1-based regimens appear effective and well tolerated, and S-1 may thus represent a useful option for advanced duodenal cancer.

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  • [ISO-abbreviation] Clin J Gastroenterol
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37. Aloysius MM, Hewavisenthi SJ, Bates TE, Rowlands BJ, Lobo DN, Zaitoun AM: Predictive value of tumor proliferative indices in periampullary cancers: Ki-67, mitotic activity index (MI) and volume corrected mitotic index (M/V) using tissue microarrays. World J Surg; 2010 Sep;34(9):2115-21
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  • The median survival for tumors of the pancreaticobiliary subtype (pancreatic ductal adenocarcinoma and cholangiocarcinoma) was 43 months in the group with an M/V score of <20, compared with 18 months for the group with a score > or =20 (P = 0.001).
  • There was no statistically significant difference in survival, based on M/V score, for tumors of the intestinal subtype (ampullary and duodenal adenocarcinoma).
  • [MeSH-major] Ampulla of Vater. Bile Duct Neoplasms / metabolism. Bile Ducts, Intrahepatic. Carcinoma, Pancreatic Ductal / metabolism. Cholangiocarcinoma / metabolism. Common Bile Duct Neoplasms / metabolism. Duodenal Neoplasms / metabolism. Ki-67 Antigen / analysis. Mitotic Index. Pancreatic Neoplasms / metabolism
  • [MeSH-minor] Humans. Immunohistochemistry. Lymphatic Metastasis. Microarray Analysis. Neoplasm Invasiveness

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  • (PMID = 20556608.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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38. Abbass R, Rigaux J, Al-Kawas FH: Nonampullary duodenal polyps: characteristics and endoscopic management. Gastrointest Endosc; 2010 Apr;71(4):754-9
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  • [Title] Nonampullary duodenal polyps: characteristics and endoscopic management.
  • BACKGROUND: Guidelines for endoscopic resection and surveillance of nonampullary duodenal (NAD) polyps are still not well-defined.
  • Most lesions were sessile, solitary, and located in the descending duodenum.
  • Colon adenomas were found in 53% of patients with duodenal adenomas.
  • CONCLUSION: NAD polyps were large, sessile, and more commonly found in the second portion of the duodenum.
  • [MeSH-major] Duodenal Neoplasms / surgery. Duodenoscopy / methods. Intestinal Polyps / surgery
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adenoma / diagnosis. Adenoma / pathology. Adenoma / surgery. Biopsy. Carcinoid Tumor / diagnosis. Carcinoid Tumor / pathology. Carcinoid Tumor / surgery. Duodenum / pathology. Duodenum / surgery. Equipment Design. Follow-Up Studies. Humans. Hyperplasia. Intestinal Mucosa / pathology. Intestinal Mucosa / surgery. Laser Therapy. Lasers, Gas. Lipoma / diagnosis. Lipoma / pathology. Lipoma / surgery. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / surgery. Retrospective Studies

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  • [Copyright] Copyright 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20363416.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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39. Bach P, Möhring C, Krawzak HW, Goepel M: [Retroperitoneal extravasation as the primary symptom of a pancreatic carcinoma]. Urologe A; 2007 Nov;46(11):1548-50
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  • Adenocarcinoma of the pancreas has a low 5-year survival rate of approximately 5%.
  • In particular, individuals suffering from carcinomas located within the pancreatic tail are at high risk of a missed diagnosis.
  • An adenocarcinoma of the pancreatic tail was diagnosed in this case report based on a large retroperitoneal extravasation missing further symptoms.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnostic imaging. Extravasation of Diagnostic and Therapeutic Materials / diagnostic imaging. Pancreatic Neoplasms / diagnostic imaging
  • [MeSH-minor] Aorta, Abdominal / pathology. Diagnosis, Differential. Duodenum / pathology. Gastroenterostomy. Humans. Male. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Staging. Palliative Care. Retroperitoneal Space / diagnostic imaging. Tomography, X-Ray Computed. Ureter / pathology. Urinoma / diagnostic imaging. Urography

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  • (PMID = 17786402.001).
  • [ISSN] 0340-2592
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] Journal Article
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40. Gupte PA, Desai HG: Is the presence or absence of Helicobacter pylori in gastric mucosa a greater risk? J Assoc Physicians India; 2005 Sep;53:783-6
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  • Helicobacter pylori is a unique organism which is pathogenic for stomach-duodenum (chronic gastritis, duodenal ulcer, gastric ulcer, gastric malignancy, mucosa-associated lymphoid tissue (MALT) lymphoma) and protective for oesophagus (Barrett's oesophagus, oesophageal adenocarcinoma) at the same time in an individual.
  • [MeSH-major] Gastric Mucosa / microbiology. Gastric Mucosa / physiopathology. Helicobacter Infections / diagnosis. Helicobacter pylori / isolation & purification
  • [MeSH-minor] Adenocarcinoma / prevention & control. Barrett Esophagus / prevention & control. Disease Progression. Esophageal Neoplasms / prevention & control. Humans. Lymphoma, B-Cell, Marginal Zone / etiology. Lymphoma, B-Cell, Marginal Zone / microbiology. Prevalence. Risk Assessment. Risk Factors. Stomach Neoplasms / etiology. Stomach Neoplasms / microbiology. Stomach Ulcer / etiology. Stomach Ulcer / microbiology

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  • [CommentIn] J Assoc Physicians India. 2006 Jan;54:77; author reply 77 [16649744.001]
  • (PMID = 16334624.001).
  • [ISSN] 0004-5772
  • [Journal-full-title] The Journal of the Association of Physicians of India
  • [ISO-abbreviation] J Assoc Physicians India
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 45
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41. Uemura K, Murakami Y, Hayashidani Y, Sudo T, Hashimoto Y, Ohge H, Takesue Y, Arihiro K, Sueda T: Invasive papillary mucinous carcinoma arising in the small branch duct cystic lesion of the pancreas. Pancreas; 2006 Mar;32(2):221-2
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  • [Title] Invasive papillary mucinous carcinoma arising in the small branch duct cystic lesion of the pancreas.
  • [MeSH-major] Adenocarcinoma, Mucinous / surgery. Carcinoma, Pancreatic Ductal / surgery. Carcinoma, Papillary / surgery. Pancreatic Cyst / pathology. Pancreatic Ducts
  • [MeSH-minor] Aged. Duodenum / pathology. Female. Humans. Neoplasm Invasiveness. Pancreatectomy. Time Factors. Treatment Outcome

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  • (PMID = 16552346.001).
  • [ISSN] 1536-4828
  • [Journal-full-title] Pancreas
  • [ISO-abbreviation] Pancreas
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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42. Mitsuhashi T, Ghafari S, Chang CY, Gu M: Endoscopic ultrasound-guided fine needle aspiration of the pancreas: cytomorphological evaluation with emphasis on adequacy assessment, diagnostic criteria and contamination from the gastrointestinal tract. Cytopathology; 2006 Feb;17(1):34-41
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  • OBJECTIVE: Endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) has been proved to be safe, efficient and reliable in the diagnosis of pancreatic lesions.
  • Three atypical, two negative, and two unsatisfactory cases proved to have adenocarcinoma.
  • Contamination from duodenum, stomach or pancreas was found in 77 positive/suspicious, three atypical and 90 negative cases.
  • CONCLUSIONS: EUS FNA is efficient and accurate in the diagnosis of pancreatic neoplasms in adequate samples.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Endosonography / methods. Female. Gastrointestinal Tract / pathology. Humans. Male. Middle Aged. Pancreas / pathology. Predictive Value of Tests. Retrospective Studies. Sensitivity and Specificity


43. Cienfuegos JA, Baixauli J, Zozaya G, Bueno A, Arredondo J, Regueira FM, Angós R, Hernández-Lizoáin JL, Idoate MA: Peutz-Jeghers syndrome and duodeno-jejunal adenocarcinoma--therapeutic implications. Rev Esp Enferm Dig; 2009 Dec;101(12):875-9
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  • [Title] Peutz-Jeghers syndrome and duodeno-jejunal adenocarcinoma--therapeutic implications.
  • Hemminki in 1997 described the presence of LKB-1 mutation tumor-suppressor gen.The patients with PJS develop a higher cumulative incidence of gastrointestinal, pancreas and extraintestinal tumors, being occasion of a renew interest on hamartomatous polyposis syndromes regarding the clinical care, cancer surveillance treatment and long term follow-up.We report the case of a 38 years old male, diagnosed of PJS who developed a multiple adenocarcinoma in duodenum and yeyunum.
  • [MeSH-major] Adenocarcinoma. Duodenal Neoplasms. Jejunal Neoplasms. Neoplasms, Multiple Primary. Peutz-Jeghers Syndrome / complications
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Disease-Free Survival. Female. Follow-Up Studies. Humans. Infant. Infant, Newborn. Male. Neoplasm Invasiveness / pathology. Pancreaticoduodenectomy. Radiography, Abdominal. Time Factors. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 20082550.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Spain
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44. Vladov NN, Takorov IR, Mutafchiiski VM, Kjossev KT, Kazarov K, Mladenov N, Petrov N: Successful emergency pancreatoduodenectomy in a non-trauma patient. Hepatogastroenterology; 2007 Sep;54(78):1844-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma / surgery. Jaundice, Obstructive / surgery. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Adult. Duodenum / surgery. Emergencies. Female. Humans. Pancreas / surgery. Tomography, X-Ray Computed / methods. Treatment Outcome

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  • (PMID = 18019731.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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45. Madanur MA, Battula N, Azam MO, Heaton N, Rela M: Chylous ascites after pancreatico-duodenectomy cholangiocarcinoma xenografts in nude mice. Hepatobiliary Pancreat Dis Int; 2007 Aug;6(4):416-9
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  • CA may be due to a consequence of occult obstruction of the proximal thoracic duct by malignant infiltration or tumor embolus.
  • Histologically, resected specimen confirmed pancreatic adenocarcinoma in all the patients.
  • [MeSH-major] Chylous Ascites / diagnosis. Chylous Ascites / metabolism. Duodenum / surgery. General Surgery / methods. Liver Neoplasms / diagnosis. Liver Neoplasms / pathology. Pancreas / surgery
  • [MeSH-minor] Aged. Female. Humans. Lymph Node Excision. Male. Middle Aged. Neoplasm Transplantation. Peritoneum / metabolism. Postoperative Complications. Retrospective Studies

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  • (PMID = 17690041.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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46. Catania C, Pelosi G, Fazio N, Biffi R, Spitaleri G, Noberasco C, Zampino MG, Maggioni A, Trifirò G, Toffalorio F, Vigna PD, De Braud F, De Pas T: A FOLFIRI-induced complete tumor response in a patient with FOLFOX-refractory metastatic duodenal adenocarcinoma. Acta Oncol; 2010;49(1):120-1
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  • [Title] A FOLFIRI-induced complete tumor response in a patient with FOLFOX-refractory metastatic duodenal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Duodenal Neoplasms / drug therapy
  • [MeSH-minor] Camptothecin / analogs & derivatives. Camptothecin / therapeutic use. Drug Resistance, Neoplasm / drug effects. Female. Fluorouracil / therapeutic use. Humans. Leucovorin / therapeutic use. Middle Aged. Organoplatinum Compounds / therapeutic use

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  • Hazardous Substances Data Bank. FLUOROURACIL .
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  • (PMID = 20100147.001).
  • [ISSN] 1651-226X
  • [Journal-full-title] Acta oncologica (Stockholm, Sweden)
  • [ISO-abbreviation] Acta Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin; Folfox protocol; IFL protocol
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47. Nathan H, Singhal S, Cameron JL: Benign pneumatosis intestinalis in the setting of celiac disease. J Gastrointest Surg; 2006 Jun;10(6):890-4
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  • We report the case of a 51-year-old man with celiac disease who underwent resection of a large duodenal adenocarcinoma.
  • Abdominal imaging revealed extensive small bowel pneumatosis and pneumoperitoneum.
  • [MeSH-minor] Adenocarcinoma / complications. Duodenal Neoplasms / complications. Humans. Male. Middle Aged. Pneumoperitoneum / complications. Pneumoperitoneum / diagnostic imaging. Tomography, X-Ray Computed

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  • [Cites] Orv Hetil. 2005 Feb 20;146(8):369-74 [15803888.001]
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  • (PMID = 16769547.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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48. Inagaki M, Obara M, Suzuki S, Ishizaki A, Takahashi K, Matsumoto K, Haneda M, Tokusashi Y, Miyokawa N, Kasai S: Mucinous carcinoma of Vater's ampulla with a unique extension along the main pancreatic duct. J Hepatobiliary Pancreat Surg; 2007;14(5):518-21
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  • Abdominal computed tomography (CT) demonstrated swelling in the head of the pancreas with a mass in the duodenum.
  • A biopsy specimen of the tumor showed moderately differentiated adenocarcinoma.
  • A pylorus-preserving pancreaticoduodenectomy with a regional lymphadenectomy was performed, under a preoperative diagnosis of adenocarcinoma of Vater's ampulla with direct invasion into the head of the pancreas.
  • The resected specimen of the duodenum confirmed the presence of the mass, which measured 22 x 15 mm in size, in Vater's ampulla.
  • Microscopically, the tumor consisted of two components: moderately differentiated adenocarcinoma in the peripheral region of the tumor Vater's papilla and mucinous carcinoma in the central region of the tumor.
  • Immunohistochemically, both the moderately differentiated adenocarcinoma and the mucinous carcinoma were positive for cytokeratin 20 (CK20) and negative for cytokeratin 7 (CK7) which is the pattern of intestinal-type carcinoma of Vater's ampulla.
  • We concluded that the original site of this tumor may have been the duodenal epithelium of Vater's ampulla originally moderately differentiated adenocarcinoma-which subsequently changed to mucinous carcinoma that extended along only the MPD with microinvasion to the pancreas.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Humans. Male. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 17909724.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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49. Miller G, Yim D, Macari M, Harris M, Shamamian P: Retroperitoneal perforation of the duodenum from biliary stent erosion. Curr Surg; 2005 Sep-Oct;62(5):512-5
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  • [Title] Retroperitoneal perforation of the duodenum from biliary stent erosion.
  • An unusual complication of indewelling biliary stents is duodenal perforation into the retroperitoneum.
  • We describe the case of a patient with end-stage pancreatic cancer who presented with an acute abdomen from erosion of a previously placed bile duct stent through the wall of the second portion of the duodenum.
  • Definitive diagnosis is best made with computed tomography (CT) imaging, which can detect traces of retroperitoneal air and fluid.
  • Complications of management can include duodenal fistulization, residual retroperitoneal or intrabdominal abscess, and ongoing sepsis.
  • This report highlights the salient issues in the presentation, diagnosis, and modern management of patients with this rare complication of indwelling biliary stents.
  • [MeSH-major] Duodenal Obstruction / etiology. Duodenal Obstruction / surgery. Foreign-Body Migration / surgery. Intestinal Perforation / etiology. Intestinal Perforation / surgery. Stents / adverse effects
  • [MeSH-minor] Abdominal Pain / diagnosis. Abdominal Pain / etiology. Adenocarcinoma / pathology. Adenocarcinoma / therapy. Aged. Follow-Up Studies. Humans. Jaundice, Obstructive / diagnosis. Jaundice, Obstructive / therapy. Laparotomy / methods. Male. Palliative Care. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / therapy. Retroperitoneal Space. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16125609.001).
  • [ISSN] 0149-7944
  • [Journal-full-title] Current surgery
  • [ISO-abbreviation] Curr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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50. Weng JM, Wu WQ, Liu QY: [Hepatoid adenocarcinoma of duodenal papilla: report of a case]. Zhonghua Bing Li Xue Za Zhi; 2009 Jul;38(7):494
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  • [Title] [Hepatoid adenocarcinoma of duodenal papilla: report of a case].
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Hepatocellular / pathology. Duodenal Neoplasms / pathology
  • [MeSH-minor] Aged. Ampulla of Vater / pathology. Carcinoid Tumor / pathology. Diagnosis, Differential. Endodermal Sinus Tumor / pathology. Humans. Male. alpha-Fetoproteins / metabolism

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  • (PMID = 19781206.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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51. Sasaki S, Hatanaka K, Sahara N, Uekusa T, Hirayama K, Shirahata A, Ishimaru M: Collision tumor of primary malignant lymphoma and adenocarcinoma in the colon: report of a case. Surg Today; 2010 Oct;40(10):975-81
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  • [Title] Collision tumor of primary malignant lymphoma and adenocarcinoma in the colon: report of a case.
  • This report presents the case of a 62-year-old man with a collision tumor of primary malignant lymphoma and adenocarcinoma in the cecum.
  • Malignant lymphoma was also seen in the duodenum.
  • Systemic chemotherapy was administered for the malignant lymphoma, and a complete response was thus obtained.
  • However, just after chemotherapy multiple liver metastases of adenocarcinoma emerged, and chemotherapy against adenocarcinoma was therefore continued.
  • The occurrence of synchronous lymphoma and adenocarcinoma of the colorectum is rare.
  • [MeSH-major] Adenocarcinoma / diagnosis. Cecal Neoplasms / diagnosis. Duodenal Neoplasms / diagnosis. Lymphoma, B-Cell / diagnosis. Lymphoma, Follicular / diagnosis. Neoplasms, Multiple Primary / diagnosis
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Biopsy, Needle. Colectomy / methods. Colonoscopy. Humans. Male. Middle Aged. Neoplasm Staging. Tomography, X-Ray Computed

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  • (PMID = 20872204.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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52. Okumura F, Senoo K, Yoshida M, Miyabe K, Naito I, Tanaka H, Hayashi K, Ando T, Nakazawa T, Ohara H, Hamaguchi K, Kanai M, Ito K, Joh T: [A case of peritoneal dissemination from mucinous carcinoma of the duodenum, which was associated with tumor thrombosis in the accessory pancreatic duct and successfully treated by chemotherapy]. Nihon Shokakibyo Gakkai Zasshi; 2009 Dec;106(12):1736-43
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  • [Title] [A case of peritoneal dissemination from mucinous carcinoma of the duodenum, which was associated with tumor thrombosis in the accessory pancreatic duct and successfully treated by chemotherapy].
  • Endoscopic examination of the upper gastrointestinal tract revealed a type 3 tumor in the descending limb of the duodenum.
  • A diagnosis of adenocarcinoma was made on the basis of the histological analysis of the biopsy sample.
  • The pathological findings indicated primary duodenal cancer (mucinous carcinoma) associated with tumor thrombosis in the accessory pancreatic duct.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Duodenal Neoplasms / pathology. Neoplastic Cells, Circulating / pathology. Pancreatic Ducts / pathology. Peritoneal Neoplasms / secondary

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  • (PMID = 19966515.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 30
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53. Kostakou C, Khaldi L, Flossos A, Kapsoritakis AN, Potamianos SP: Melena: a rare complication of duodenal metastases from primary carcinoma of the lung. World J Gastroenterol; 2007 Feb 28;13(8):1282-5
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  • [Title] Melena: a rare complication of duodenal metastases from primary carcinoma of the lung.
  • Small bowel metastases from primary carcinoma of the lung are very uncommon and occur usually in patients with terminal stage disease.
  • Hemorrhage as a first presentation of small bowel metastases is extremely rare and is related to very poor patient survival.
  • We describe a case of a 61- year old patient with primary adenocarcinoma of the lung, presenting with melena as the first manifestation of small bowel metastasis.
  • Upper gastrointestinal endoscopy performed with a colonoscope revealed active bleeding from a metastatic tumor involving the duodenum and the proximal jejunum.
  • Histological examination and immunohistochemical staining of the biopsy specimen strongly supported the diagnosis of metastatic lung adenocarcinoma, suggesting that small bowel metastases from primary carcinoma of the lung occur usually in patients with terminal disease and rarely produce symptoms.
  • Gastrointestinal bleeding from metastatic small intestinal lesions should be included in the differential diagnosis of gastrointestinal blood loss in a patient with a known bronchogenic tumor.
  • [MeSH-major] Adenocarcinoma / secondary. Duodenal Neoplasms / secondary. Lung Neoplasms / pathology. Melena / etiology

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  • (PMID = 17451216.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4147010
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54. Shimizu M, Kawaguchi A, Nagao S, Hozumi H, Komoto S, Hokari R, Miura S, Hatsuse K, Ogata S: A case of intraductal papillary mucinous neoplasm of the pancreas rupturing both the stomach and duodenum. Gastrointest Endosc; 2010 Feb;71(2):406-12
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  • [Title] A case of intraductal papillary mucinous neoplasm of the pancreas rupturing both the stomach and duodenum.
  • BACKGROUND: Intraductal papillary mucinous neoplasm (IPMN) of the pancreas may extend to other organs.
  • There has been no report of a benign IPMN rupturing both the stomach and duodenum.
  • Intraluminal nodular growth was observed in the duodenal gland tissue, and abnormal growth was observed in the fistula to the stomach.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Carcinoma, Pancreatic Ductal / secondary. Carcinoma, Papillary / secondary. Duodenal Neoplasms / secondary. Pancreatic Neoplasms / pathology. Stomach Neoplasms / secondary
  • [MeSH-minor] Aged. Cholangiopancreatography, Endoscopic Retrograde / methods. Endosonography / methods. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness / pathology. Pancreaticoduodenectomy / methods. Rare Diseases. Risk Assessment. Rupture, Spontaneous / etiology. Rupture, Spontaneous / surgery. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19922925.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 22
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55. Hatzaras I, Palesty JA, Abir F, Sullivan P, Kozol RA, Dudrick SJ, Longo WE: Small-bowel tumors: epidemiologic and clinical characteristics of 1260 cases from the connecticut tumor registry. Arch Surg; 2007 Mar;142(3):229-35
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  • [Title] Small-bowel tumors: epidemiologic and clinical characteristics of 1260 cases from the connecticut tumor registry.
  • OBJECTIVE: To examine the epidemiology and clinical characteristics of small-bowel cancer.
  • DESIGN: Patients with small-bowel tumors reported between 1980 and 2000, studied retrospectively.
  • PATIENTS: One thousand sixty small-bowel cancer cases: 628 men (49.84%) and 632 women (50.16%).
  • RESULTS: The most common location of small-bowel tumors was the ileum (374 cases; 29.7%), followed by the duodenum (320 cases; 25.4%) and the jejunum (193 cases; 15.3%).
  • The most prevalent histologic type was carcinoid (417 cases; 33%), followed by adenocarcinoma (341 cases; 27%) and lymphoma (205 cases; 16.3%).
  • CONCLUSIONS: The incidence of small-bowel tumors in Connecticut has increased during the past 2 decades, with the highest rate of increase in men.
  • Carcinoid tumors are the most common small intestinal cancers identified histologically, followed by adenocarcinomas.
  • The former seems to be more frequently seen in the ileum, the latter in the duodenum.
  • Surgery is the treatment of choice for the cure or palliation of small-bowel cancers.
  • [MeSH-major] Duodenal Neoplasms / epidemiology. Ileal Neoplasms / epidemiology. Jejunal Neoplasms / epidemiology

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  • (PMID = 17372046.001).
  • [ISSN] 0004-0010
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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56. Uvarov IB, Genrikh SR, Liutov DA, Shatov MN, Onopriev VI: [Primary jejunogastroplasty with end-loop gastroenteroanastomosis and inclusion of the duodenum in distal resection of the stomach (surgical technology and functional results)]. Vestn Khir Im I I Grek; 2008;167(1):37-42
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  • [Title] [Primary jejunogastroplasty with end-loop gastroenteroanastomosis and inclusion of the duodenum in distal resection of the stomach (surgical technology and functional results)].
  • Complex examination of 57 patients (25 patients of the main group, and 32 controls) has shown that the proposed technology of primary JGP can reliably prevent gastroesophageal and duodeno-enterogastic reflux, creates conditions for the portion-rhythmical evacuation of food from the gastric stump.
  • [MeSH-major] Anastomosis, Roux-en-Y / methods. Duodenum / surgery. Gastroplasty. Jejunum / surgery. Stomach / surgery
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / surgery. Adult. Aged. Female. Gastrointestinal Neoplasms / epidemiology. Gastrointestinal Neoplasms / surgery. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 18411666.001).
  • [ISSN] 0042-4625
  • [Journal-full-title] Vestnik khirurgii imeni I. I. Grekova
  • [ISO-abbreviation] Vestn. Khir. Im. I. I. Grek.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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57. Buecher B, Baert-Desurmont S, Leborgne J, Humeau B, Olschwang S, Frébourg T: Duodenal adenocarcinoma and Mut Y human homologue-associated polyposis. Eur J Gastroenterol Hepatol; 2008 Oct;20(10):1024-7
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  • [Title] Duodenal adenocarcinoma and Mut Y human homologue-associated polyposis.
  • Among these, duodenal polyposis, a highly prevalent manifestation of Adenomatous Polyposis Coli related familial adenomatous polypyposis, is undoubtedly part of the clinical spectrum of the disease.
  • The true association of other clinical manifestations with MAP remains questionable.We report the observation of two patients affected by MAP who developed an adenocarcinoma of the duodenum in the context of duodenal polyposis.
  • These observations emphasize the malignant potential of MAP-associated duodenal polyposis and the need to enroll these patients into an upper gastrointestinal surveillance programme.
  • [MeSH-major] Adenocarcinoma / genetics. Adenomatous Polyposis Coli / genetics. Colorectal Neoplasms / genetics. DNA Glycosylases / genetics. Duodenal Neoplasms / genetics. Mutation, Missense

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  • (PMID = 18787472.001).
  • [ISSN] 1473-5687
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
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58. Ramia JM, Villar J, Palomeque A, Muffak K, Mansilla A, Garrote D, Ferrón JA: [Duodenal adenocarcinoma]. Cir Esp; 2005 Apr;77(4):208-12
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  • [Title] [Duodenal adenocarcinoma].
  • [Transliterated title] Adenocarcinoma de duodeno.
  • INTRODUCTION: Duodenal adenocarcinoma is an infrequent neoplasm.
  • Consequently, there are no large series that would allow conclusions to be reached on its diagnosis and treatment.
  • PATIENTS AND METHOD: A retrospective study (1999-2003) of five patients diagnosed with duodenal adenocarcinoma in our service was performed.
  • All patients underwent gastrointestinal endoscopy with biopsy, which revealed adenocarcinoma.
  • In all patients, the preoperative diagnosis was correct.
  • CONCLUSION: Duodenal adenocarcinoma is an infrequent tumor that is associated with various diseases.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Duodenal Neoplasms / diagnosis. Duodenal Neoplasms / surgery

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  • (PMID = 16420919.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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59. Al-Amri A, Al-Quorain AA: Coexisting malignant lymphoma of the duodenum and adenocarcinoma of the colon. Saudi Med J; 2007 Mar;28(3):463-4
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  • [Title] Coexisting malignant lymphoma of the duodenum and adenocarcinoma of the colon.
  • Synchronous malignant mucosa associated lymphoid tissue MALT-lymphoma of the small bowel and adenocarcinoma of the colon in the same patient is a scarce rarity.
  • Thus, it might be of interest to report such a case of coexisting malignant MALT-lymphoma of the duodenum and adenocarcinoma of the large bowel.
  • [MeSH-major] Adenocarcinoma / pathology. Colonic Neoplasms / pathology. Duodenal Neoplasms / pathology. Lymphoma, B-Cell, Marginal Zone / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 17334482.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
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60. Safatle-Ribeiro AV, Franzini TA, Kuga R, Ishida RK, Baba ER, Mendes DC, Ishioka S, Sakai P: Double-balloon enteroscopy in the diagnosis of an adenocarcinoma of the fourth portion of the duodenum: report of a case. Clinics (Sao Paulo); 2007 Jun;62(3):353-6
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  • [Title] Double-balloon enteroscopy in the diagnosis of an adenocarcinoma of the fourth portion of the duodenum: report of a case.
  • [MeSH-major] Adenocarcinoma / diagnosis. Duodenal Neoplasms / diagnosis. Endoscopy, Gastrointestinal / methods

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  • (PMID = 17589678.001).
  • [ISSN] 1807-5932
  • [Journal-full-title] Clinics (São Paulo, Brazil)
  • [ISO-abbreviation] Clinics (Sao Paulo)
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Brazil
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61. Byun JR, Jahng JH, Song JC, Yu JS, Lee DK: Supine position endoscopic retrograde cholangiopancreatography in a patient with situs ambiguous with polysplenia. Dig Endosc; 2010 Oct;22(4):322-4
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  • Microscopic findings of the biopsy specimen of papillary mass were compatible with an adenocarcinoma of the ampulla of Vater.
  • Although the success rate of supine position ERCP may be influenced by the extent of the intestinal malrotation and the position of the duodenum, we conclude that supine position ERCP can be carried out effectively in a patient with situs anomaly.
  • [MeSH-minor] Biopsy. Female. Humans. Middle Aged. Neoplasm Staging. Positron-Emission Tomography. Supine Position. Tomography, X-Ray Computed

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  • [Copyright] © 2010 The Authors. Digestive Endoscopy © 2010 Japan Gastroenterological Endoscopy Society.
  • (PMID = 21175488.001).
  • [ISSN] 1443-1661
  • [Journal-full-title] Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
  • [ISO-abbreviation] Dig Endosc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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62. Hurtuk MG, Devata S, Brown KM, Oshima K, Aranha GV, Pickleman J, Shoup M: Should all patients with duodenal adenocarcinoma be considered for aggressive surgical resection? Am J Surg; 2007 Mar;193(3):319-24; discussion 324-5
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  • [Title] Should all patients with duodenal adenocarcinoma be considered for aggressive surgical resection?
  • BACKGROUND: Long-term survival for duodenal adenocarcinoma is inconsistent in the literature, and the biology of duodenal adenocarcinoma is poorly understood.
  • METHODS: One institution's experience with duodenal adenocarcinoma from 1984 to 2005 is reviewed.
  • CONCLUSIONS: Clinicopathologic factors important to survival in duodenal cancer are T4 tumor status and tumor size.
  • The biology of this cancer is poorly understood; therefore, aggressive resection for all duodenal adenocarcinomas is recommended for all patients medically fit to undergo resection.
  • [MeSH-major] Adenocarcinoma / surgery. Duodenal Neoplasms / surgery. Patient Selection

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  • (PMID = 17320527.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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63. Will O, Carvajal-Carmona LG, Gorman P, Howarth KM, Jones AM, Polanco-Echeverry GM, Chinaleong JA, Günther T, Silver A, Clark SK, Tomlinson I: Homozygous PMS2 deletion causes a severe colorectal cancer and multiple adenoma phenotype without extraintestinal cancer. Gastroenterology; 2007 Feb;132(2):527-30
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  • BACKGROUND & AIMS: We report a patient of Indian descent with parental consanguinity, who developed 10 carcinomas and 35 adenomatous polyps at age 23 and duodenal adenocarcinoma at age 25.
  • We aimed to establish his molecular diagnosis.
  • Investigation by array-comparative genomic hybridization revealed deletion of a small region on chromosome 7.
  • [MeSH-minor] Adenomatous Polyposis Coli / diagnosis. Adult. DNA Glycosylases / genetics. Diagnosis, Differential. Duodenal Neoplasms / genetics. Fatal Outcome. Gene Expression Regulation, Neoplastic. Humans. Male. Microsatellite Instability. Mutation. Pedigree. Protein-Serine-Threonine Kinases. Proto-Oncogene Proteins / genetics. Receptors, Transforming Growth Factor beta / genetics. Severity of Illness Index. ras Proteins

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  • (PMID = 17258725.001).
  • [ISSN] 0016-5085
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / KRAS protein, human; 0 / Proto-Oncogene Proteins; 0 / Receptors, Transforming Growth Factor beta; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.30 / transforming growth factor-beta type II receptor; EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase; EC 3.6.1.- / Adenosine Triphosphatases; EC 3.6.1.- / PMS2 protein, human; EC 3.6.5.2 / ras Proteins; EC 6.5.1.- / DNA Repair Enzymes
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64. Kim YK, Han YM, Kim CS: Usefulness of fat-suppressed T1-weighted MRI using orally administered superparamagnetic iron oxide for revealing ampullary carcinomas. J Comput Assist Tomogr; 2007 Jul-Aug;31(4):519-25
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  • The images were compared quantitatively by measuring the tumor-pancreas (duodenum) contrast-to-noise ratio and, qualitatively, by evaluating tumor conspicuity.
  • RESULTS: For the tumor-pancreas (duodenum) contrast-to-noise ratio, the FLASH was significantly higher than those of the dynamic set and RT-TSE (P < 0.05).
  • [MeSH-major] Adenocarcinoma / diagnosis. Ampulla of Vater. Common Bile Duct Neoplasms / diagnosis. Contrast Media. Ferric Compounds. Image Enhancement / methods. Magnetic Resonance Imaging / methods

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  • (PMID = 17882025.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Ferric Compounds; 1K09F3G675 / ferric oxide
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65. Wakatsuki T, Irisawa A, Takagi T, Koyama Y, Hoshi S, Takenoshita S, Abe M, Ohira H: Primary adenocarcinoma of the minor duodenal papilla. Yonsei Med J; 2008 Apr 30;49(2):333-6
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  • [Title] Primary adenocarcinoma of the minor duodenal papilla.
  • Upper gastrointestinal endoscopy revealed a flat elevated tumor with central ulceration in the second portion of the duodenum.
  • Subsequent duodenoscopy for a more detailed examination showed that the tumor had originated in the minor duodenal papilla.
  • A biopsy specimen showed moderately differentiated adenocarcinoma.
  • Endoscopic retrograde pancreatography via the major duodenal papilla revealed a slightly dilated main pancreatic duct and obstruction of the accessory pancreatic duct.
  • Endoscopic ultrasonography showed a hypoechoic mass in the minor duodenal papilla with retention of the muscularis propria of the duodenum.
  • These findings suggest that the tumor existed only to a limited extent in the minor duodenal papilla, and that the tumor did not infiltrate into the pancreas.
  • For treatment, pylorus-preserving pancreatoduodenectomy was performed, and histological findings revealed a well-differentiated adenocarcinoma that originated in the minor duodenal papilla.
  • Primary adenocarcinoma of the minor duodenal papilla is extremely rare.
  • Our case is the first report of primary adenocarcinoma of the minor duodenal papilla at an early stage with no infiltration into muscularis propria of the duodenum and pancreas.
  • [MeSH-major] Adenocarcinoma / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 18452274.001).
  • [ISSN] 0513-5796
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2615313
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66. Overman MJ, Kopetz S, Wen S, Hoff PM, Fogelman D, Morris J, Abbruzzese JL, Ajani JA, Wolff RA: Chemotherapy with 5-fluorouracil and a platinum compound improves outcomes in metastatic small bowel adenocarcinoma. Cancer; 2008 Oct 15;113(8):2038-45
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  • [Title] Chemotherapy with 5-fluorouracil and a platinum compound improves outcomes in metastatic small bowel adenocarcinoma.
  • BACKGROUND: Metastatic small bowel adenocarcinoma (SBA) has a poor prognosis.
  • The primary tumor site was the jejunum in 35 patients (43%), duodenum in 30 patients (38%), ileum in 6 patients (8%), and nonspecified small bowel in 9 patients (11%).
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Intestinal Neoplasms / drug therapy. Intestine, Small / pathology
  • [MeSH-minor] Adult. Aged. Disease-Free Survival. Female. Fluorouracil / administration & dosage. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Platinum Compounds / administration & dosage. Retrospective Studies

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  • [Copyright] (c) 2008 American Cancer Society.
  • (PMID = 18759326.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Platinum Compounds; U3P01618RT / Fluorouracil
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67. Terada T: Primary Pure Squamous Cell Carcinoma of the Duodenum: A Case Report. Gastroenterology Res; 2010 Feb;3(1):39-40
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  • [Title] Primary Pure Squamous Cell Carcinoma of the Duodenum: A Case Report.
  • : Only two cases of squamous cell carcinoma of the duodenum have been reported in the literature.
  • The author herein reports a case of squamous cell carcinoma of the duodenum.
  • An endoscopic examination revealed a duodenal tumor.
  • The tumor was circumferential elevated one with duodenal obstruction, and located in the descending part near and distal to the ampulla of Vater.
  • Imaging modalities also detected the duodenal tumor, but did not show tumors of other locations including the pancreas.
  • The duodenal tumor was different from ampullary tumor and pancreatic tumor.
  • Six biopsies were obtained from the duodenal tumor.
  • All the six biopsies showed malignant cells arranged in a medullary pattern.
  • The malignant cells showed hyperchromatic nuclei, and mitotic figures were scattered.
  • The pathologic features were interpreted as a squamous cell carcinoma of the duodenum.
  • The carcinoma was pure squamous cell carcinoma without differentiation into adenocarcinoma or endocrine carcinoma.

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  • (PMID = 27956983.001).
  • [ISSN] 1918-2805
  • [Journal-full-title] Gastroenterology research
  • [ISO-abbreviation] Gastroenterology Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Keywords] NOTNLM ; Duodenum / Histopathology / Squamous cell carcinoma
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68. Lundgren A, Strömberg E, Sjöling A, Lindholm C, Enarsson K, Edebo A, Johnsson E, Suri-Payer E, Larsson P, Rudin A, Svennerholm AM, Lundin BS: Mucosal FOXP3-expressing CD4+ CD25high regulatory T cells in Helicobacter pylori-infected patients. Infect Immun; 2005 Jan;73(1):523-31
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  • Helicobacter pylori chronically colonizes the stomach and duodenum and causes peptic ulcers or gastric adenocarcinoma in 10 to 20% of infected individuals.
  • Here we show that H. pylori-infected individuals have increased frequencies of CD4(+) CD25(high) T cells in both the stomach and duodenal mucosa compared to uninfected controls.
  • Mucosal CD4(+) CD25(high) T cells are present in individuals with asymptomatic H. pylori infections as well as in duodenal ulcer patients.
  • The frequencies of CD4(+) CD25(high) cells are also increased in the stomachs of H. pylori-infected patients with gastric adenocarcinoma, particularly in cancer-affected tissues.
  • [MeSH-minor] Adenocarcinoma / immunology. Adult. Antigens, CD. Antigens, Differentiation / analysis. CD4-Positive T-Lymphocytes / physiology. CTLA-4 Antigen. Duodenal Ulcer / immunology. Female. Forkhead Transcription Factors. Humans. Immunologic Memory. Male. Middle Aged. Stomach Neoplasms / immunology

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  • (PMID = 15618192.001).
  • [ISSN] 0019-9567
  • [Journal-full-title] Infection and immunity
  • [ISO-abbreviation] Infect. Immun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD4; 0 / Antigens, Differentiation; 0 / CTLA-4 Antigen; 0 / CTLA4 protein, human; 0 / DNA-Binding Proteins; 0 / FOXP3 protein, human; 0 / Forkhead Transcription Factors; 0 / Receptors, Interleukin-2
  • [Other-IDs] NLM/ PMC538965
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69. Murakami Y, Uemura K, Sasaki M, Morifuji M, Hayashidani Y, Sudo T, Sueda T: Duodenal cancer arising from the remaining duodenum after pylorus-preserving pancreatoduodenectomy for ampullary cancer in familial adenomatous polyposis. J Gastrointest Surg; 2005 Mar;9(3):389-92
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  • [Title] Duodenal cancer arising from the remaining duodenum after pylorus-preserving pancreatoduodenectomy for ampullary cancer in familial adenomatous polyposis.
  • We herein report a rare occurrence of duodenal cancer arising from the remaining duodenum after pylorus-preserving pancreatoduodenectomy for ampullary cancer in familial adenomatous polyposis (FAP).
  • During the current admission, the patient was diagnosed with adenocarcinoma in the Vater's ampulla using imaging and pathological examinations.
  • The tumor was a well-differentiated tubular adenocarcinoma and no other polyps were identified in the duodenum by pathological examination.
  • However, 1 year after surgery, a polypoid lesion measuring 15 x 15 mm was indicated in the remaining duodenum by endoscopic surveillance.
  • This lesion was completely resected by endoscopic mucosal resection and the resected specimen revealed well-differentiated tubular adenocarcinoma in an adenomatous lesion.
  • This report suggests that resection of the total duodenum is essential for duodenal neoplasms in FAP to prevent a recurrence in the remaining duodenum.
  • [MeSH-major] Adenocarcinoma / surgery. Adenomatous Polyposis Coli / secondary. Common Bile Duct Neoplasms / pathology. Duodenal Neoplasms / secondary. Duodenal Neoplasms / surgery. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Adult. Ampulla of Vater / pathology. Cholangiopancreatography, Endoscopic Retrograde / methods. Duodenoscopy / methods. Female. Follow-Up Studies. Humans. Neoplasm, Residual / pathology. Neoplasm, Residual / surgery. Pylorus. Risk Assessment. Treatment Outcome

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  • (PMID = 15749602.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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70. Han SL, Cheng J, Zhou HZ, Zeng QQ, Lan SH: The surgical treatment and outcome for primary duodenal adenocarcinoma. J Gastrointest Cancer; 2008;39(1-4):46-50
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  • [Title] The surgical treatment and outcome for primary duodenal adenocarcinoma.
  • BACKGROUND: Primary duodenal adenocarcinomas (PDAC) are uncommon tumors characterized by non-specific symptoms and late diagnosis, and treatments of PDAC have some controversies.
  • METHOD: To investigate the early diagnosis and outcomes of surgical treatment of PDAC, 32 patients who were treated surgically between February 1990 and September 2006 were analyzed retrospectively.
  • CONCLUSION: PD is suggested for the tumor located at the first and second portion of the duodenum, and SR may be appropriate for the selected patients, especially for tumors of the distal duodenum.
  • [MeSH-major] Adenocarcinoma / surgery. Duodenal Neoplasms / surgery

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  • [ErratumIn] J Gastrointest Cancer. 2012 Jun;43(2):390
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  • (PMID = 19399645.001).
  • [ISSN] 1941-6628
  • [Journal-full-title] Journal of gastrointestinal cancer
  • [ISO-abbreviation] J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. Quint K, Stintzing S, Alinger B, Hauser-Kronberger C, Dietze O, Gahr S, Hahn EG, Ocker M, Neureiter D: The expression pattern of PDX-1, SHH, Patched and Gli-1 is associated with pathological and clinical features in human pancreatic cancer. Pancreatology; 2009;9(1-2):116-26
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  • MATERIAL AND METHODS: Invasive ductal adenocarcinomas of the pancreas [UICC pT3pN0 (n = 13) vs. pT3pN1 (n = 25)] and tumors after neoadjuvant chemotherapy [5-fluorouracil (FU)/folic-acid and gemcitabine; UICC ypN0 (n = 7) vs. ypN1 (n = 6)] resected between 1997 and 2003 were characterized histochemically and immunohistochemically [pancreas duodenum homeobox 1 (PDX-1), Sonic hedgehog protein (SHH), Patched (Ptc) and Gli-1].
  • [MeSH-major] Adenocarcinoma / metabolism. Carcinoma, Pancreatic Ductal / metabolism. Hedgehog Proteins / biosynthesis. Homeodomain Proteins / biosynthesis. Pancreatic Neoplasms / metabolism. Receptors, Cell Surface / biosynthesis. Trans-Activators / biosynthesis. Transcription Factors / biosynthesis

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  • [Copyright] Copyright 2008 S. Karger AG, Basel and IAP.
  • (PMID = 19077462.001).
  • [ISSN] 1424-3911
  • [Journal-full-title] Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
  • [ISO-abbreviation] Pancreatology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / GLI1 protein, human; 0 / Hedgehog Proteins; 0 / Homeodomain Proteins; 0 / Receptors, Cell Surface; 0 / SHH protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / pancreatic and duodenal homeobox 1 protein; 0 / patched receptors
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72. Lienert A, Bagshaw PF: Treatment of duodenal adenomas with endoscopic argon plasma coagulation. ANZ J Surg; 2007 May;77(5):371-3
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  • [Title] Treatment of duodenal adenomas with endoscopic argon plasma coagulation.
  • BACKGROUND: Surgical resection has been the standard treatment for duodenal adenomas.
  • METHODS: We retrospectively identified patients with non-ampullary duodenal adenomas without a polyposis syndrome and who were treated endoscopically between 1st January 1999 and 31st December 2003.
  • No patient developed duodenal adenocarcinoma during the study period.
  • CONCLUSION: Argon plasma coagulation may be safe and effective for the treatment of duodenal adenomas, but further research is required.
  • [MeSH-major] Adenoma / surgery. Duodenal Neoplasms / surgery. Endoscopy, Gastrointestinal. Laser Coagulation
  • [MeSH-minor] Aged. Aged, 80 and over. Argon. Follow-Up Studies. Humans. Middle Aged. Neoplasm Recurrence, Local. Postoperative Complications. Retrospective Studies. Treatment Outcome

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  • (PMID = 17497979.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 67XQY1V3KH / Argon
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73. Boldery J, Gleeson J, Jordaan J: Superior mesenteric artery syndrome following small bowel resection. ANZ J Surg; 2006 Sep;76(9):861-2
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  • [Title] Superior mesenteric artery syndrome following small bowel resection.
  • It results from compression of the third part of the duodenum between the superior mesenteric artery and the aorta.
  • We present a case of superior mesenteric artery syndrome following resection of a primary adenocarcinoma of the small bowel.
  • [MeSH-major] Adenocarcinoma / surgery. Jejunal Neoplasms / surgery. Postoperative Complications / etiology. Superior Mesenteric Artery Syndrome / etiology


74. Bilici A, Karadag B, Doventas A, Seker M: Gastric pneumatosis intestinalis associated with malignancy: an unusual case report. World J Gastroenterol; 2009 Feb 14;15(6):758-60
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  • The most common localization is the small intestine.
  • We report on a 94-year-old man with gastric PI associated with inoperable adenocarcinoma localized in the duodenum.
  • We suggest that in patients presenting with PI, malignancy should be considered in the differential diagnosis.
  • [MeSH-major] Adenocarcinoma / diagnosis. Duodenal Neoplasms / diagnosis. Pneumatosis Cystoides Intestinalis / diagnosis. Pneumatosis Cystoides Intestinalis / radiography
  • [MeSH-minor] Aged, 80 and over. Blood Proteins / analysis. Blood Proteins / isolation & purification. Diagnosis, Differential. Fatal Outcome. Humans. Male. Stomach Diseases / diagnosis. Stomach Diseases / etiology. Stomach Diseases / radiography. Tomography, X-Ray Computed. Urine / cytology

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  • (PMID = 19222105.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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75. Sierra Ausin M, Linares Torres P, Alvarez Posadilla M, Díez Rodríguez R, Rascarachi G, Arias Rodríguez L, Olcoz Goñi JL: [Signet-ring cell adenocarcinoma of the duodenal bulb]. Gastroenterol Hepatol; 2008 Feb;31(2):107-8
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  • [Title] [Signet-ring cell adenocarcinoma of the duodenal bulb].
  • [Transliterated title] Adenocarcinoma del bulbo duodenal con células en anillo de sello.
  • [MeSH-major] Carcinoma, Signet Ring Cell / diagnosis. Duodenal Neoplasms / diagnosis

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  • (PMID = 18279652.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
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76. Meyer AL, Berger E, Monteiro Jr O, Alonso PA, Lerner JS: Radiographic study of patients submitted to total gastrectomy using Safatle reconstruction technique. Arq Gastroenterol; 2008 Jul-Sep;45(3):230-3
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  • The Safatle reconstruction of the gastrointestinal transit technique consists of, in short, in the association of the interposition of the jejunal loop with partial transit through the duodenum, with an inverted Roux-en-Y and with the creation of a pouch which resembles the dynamics of the stomach, achieved by duodenojejunal segment which has an antiperistalsis emptying.
  • They were summoned to perform contrasted radiographies of the esophagus-duodenum-jejunum by the videofluoroscopic method during the months of July and August, 2005.
  • [MeSH-major] Adenocarcinoma / surgery. Anastomosis, Roux-en-Y / methods. Duodenum / radiography. Jejunum / radiography. Stomach / radiography. Stomach Neoplasms / surgery

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  • (PMID = 18852952.001).
  • [ISSN] 1678-4219
  • [Journal-full-title] Arquivos de gastroenterologia
  • [ISO-abbreviation] Arq Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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77. Tonelli F, Bargellini T, Leo F, Nesi G: Duodenal adenocarcinoma arising at the strictureplasty site in a patient with Crohn's disease: report of a case. Int J Colorectal Dis; 2009 Apr;24(4):475-7
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  • [Title] Duodenal adenocarcinoma arising at the strictureplasty site in a patient with Crohn's disease: report of a case.
  • [MeSH-major] Crohn Disease / complications. Crohn Disease / surgery. Duodenal Neoplasms / etiology


78. Grapin-Botton A: Ductal cells of the pancreas. Int J Biochem Cell Biol; 2005 Mar;37(3):504-10
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  • Ductal cells of the pancreas form the epithelial lining of the branched tubes that deliver enzymes produced by pancreatic acinar cells into the duodenum.
  • During development, epithelium of endodermal origin evaginates from the future duodenum area and invades the mesenchyme to form a complex branched network.
  • In addition, in the main form of pancreatic cancer, pancreas adenocarcinoma, tumor cells share similarities with ductal cells.

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  • (PMID = 15618005.001).
  • [ISSN] 1357-2725
  • [Journal-full-title] The international journal of biochemistry & cell biology
  • [ISO-abbreviation] Int. J. Biochem. Cell Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 34
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79. Watanabe M, Yamazaki K, Yajima S, Tsuchiya M, Otsuka Y, Tamura A, Oshima Y, Kaneko H, Shimokawa K: Fourteen-years of disease-free survival in a patient with advanced gallbladder carcinoma after radical resection: a case report. Hepatogastroenterology; 2009 Mar-Apr;56(90):335-8
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  • A preoperative diagnosis of advanced GBC with invasion into the liver bed, the abdominal wall, the duodenum, the common bile duct and the hepatic flexure of the colon were made.
  • On histopathology, the resected specimen showed a well-differentiated adenocarcinoma and the 56 resected lymph nodes showed no evidence of metastasis.
  • [MeSH-major] Adenocarcinoma / surgery. Gallbladder Neoplasms / diagnosis. Gallbladder Neoplasms / surgery
  • [MeSH-minor] Cholecystectomy. Colectomy. Colonoscopy. Contrast Media. Diagnosis, Differential. Disease-Free Survival. Female. Humans. Middle Aged. Pancreaticoduodenectomy. Tomography, X-Ray Computed

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  • (PMID = 19579593.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Contrast Media
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80. Yamaoka K, Inatsugi N, Yoshikawa S, Masuda T, Uchida H, Kuge H, Yokotani T, Yamaguchi T, Kawaguchi C, Shimobayashi T, Inagaki M, Matsuoka M, Tatsumi K, Saraya T, Otsuji T, Yamochi Y, Yamanishi K, Enomoto Y, Nonomura A, Sho M, Nakajima Y: [A surgical (pancreatoduodenectomy) case of lymph node metastatic recurrence of colon cancer after chemotherapy]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2346-8
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  • A woman in her fifties underwent a right hemicolectomy (D3) for cancer of the ascending colon in October 2007, definitively and pathologically diagnosed as papillary adenocarcinoma invading to the subserosa, and no metastasis was detected to lymph node.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Adenocarcinoma, Papillary / therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colonic Neoplasms / pathology. Colonic Neoplasms / therapy. Lymphatic Metastasis / pathology. Pancreatic Neoplasms / secondary. Pancreatic Neoplasms / therapy
  • [MeSH-minor] Duodenum / surgery. Female. Fluorouracil / therapeutic use. Humans. Leucovorin / therapeutic use. Middle Aged. Neoplasm Recurrence, Local. Organoplatinum Compounds / therapeutic use. Pancreatectomy

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  • (PMID = 21224568.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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81. Srilatha PS: Concurrence of duodenal carcinoid and diffuse gastric adenocarcinoma: a rare phenomenon. Saudi J Gastroenterol; 2007 Oct-Dec;13(4):197-9
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  • [Title] Concurrence of duodenal carcinoid and diffuse gastric adenocarcinoma: a rare phenomenon.
  • There are a few studies, which highlight the incidental finding of the yellow beauty-the "carcinoid" of the duodenum simultaneously occurring with the venomous "diffuse gastric adenocarcinoma".

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  • (PMID = 19858647.001).
  • [ISSN] 1998-4049
  • [Journal-full-title] Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
  • [ISO-abbreviation] Saudi J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
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82. Goh BK, Yeo AW, Koong HN, Ooi LL, Wong WK: Laparotomy for acute complications of gastrointestinal metastases from lung cancer: is it a worthwhile or futile effort? Surg Today; 2007;37(5):370-4
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  • The sites of symptomatic GIT metastases include the ileum (n = 3), jejunum (n = 3), cecum (n = 1), duodenum (n = 2) and stomach (n = 2) and the patients presented with obstruction (n = 2), hemorrhage (n = 3), intussusception (n = 3) and perforation (n = 1).
  • The median time of symptomatic GIT metastases from initial presentation was 2 months (range, 0-8 months) and the histological subtypes of the lung cancer were squamous cell carcinoma (n = 3), large cell carcinoma (n = 3), adenocarcinoma (n = 1), pleomorphic carcinoma (n = 1) and pleomorphic with adenocarcinoma (n = 1).
  • These included a small bowel resection with primary anastomosis (n = 5), a subtotal gastrectomy with an extended right hemicolectomy (n = 1), a gastrojejunostomy (n = 1), a right hemicolectomy (n = 1), and an ulcerectomy with under-running of ulcers (n = 1).
  • CONCLUSION: Gastrointestinal tract metastases should always be considered in the differential diagnosis of lung cancer patients presenting with an acute abdomen.

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  • (PMID = 17468816.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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83. Farhat MH, Shamseddine AI, Barada KA: Small bowel tumors: clinical presentation, prognosis, and outcome in 33 patients in a tertiary care center. J Oncol; 2008;2008:212067
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  • [Title] Small bowel tumors: clinical presentation, prognosis, and outcome in 33 patients in a tertiary care center.
  • Introduction. Small bowel cancers are rare.
  • Methods. This is a retrospective study of the medical records of 33 patients with small bowel cancers treated at the American University of Beirut-Medical Center over a 20-year period.
  • Lymphoma was the most common malignant tumor (36.4%), followed by adenocarcinoma (33.3%), leiomyosarcoma (15.2%), gastrointestinal stromal tumors (12.1%), and neuroendocrine tumors (3.0%).
  • Tumors were located in the duodenum in 30% of patients, jejunum in 33%, and ileum in 36%.
  • Conclusion. Small bowel cancers are difficult to diagnose because of the nonspecific symptoms.
  • Adenocarcinoma and duodenal location have the worst 5-year survival in contrast to stromal tumors and those with ileal location which have the best survival.

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  • (PMID = 19266087.001).
  • [ISSN] 1687-8450
  • [Journal-full-title] Journal of oncology
  • [ISO-abbreviation] J Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2648638
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84. Hol JW, Stuifbergen WN, Teepen JL, van Laarhoven CJ: Giant Brunner's hamartomas of the duodenum and obstructive jaundice. An overview of the literature and suspicion of malignancy in a case. Dig Surg; 2007;24(6):452-5
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  • [Title] Giant Brunner's hamartomas of the duodenum and obstructive jaundice. An overview of the literature and suspicion of malignancy in a case.
  • METHODS: In this case report, a 60-year-old male is presented with unexplained obstructive jaundice who was also known for over 17 years with diffuse adenomatous hyperplasia of Brunner's glands in the duodenum.
  • Despite the benign preoperative diagnosis, the choice of treatment was Whipple's procedure due to suspicion of a coexisting malignancy.
  • RESULTS: Pathological analysis of the resection specimen revealed multiple BGHs and an adenocarcinoma of the papilla of Vater (PoV).
  • CONCLUSION: It is likely that previous reports of malignant degeneration of BGHs may actually have been cases involving the coexistence of a PoV adenocarcinoma.
  • Physicians need to be alert when a patient presents with BGH accompanied with obstructive jaundice for simultaneously occurring PoV adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / epidemiology. Ampulla of Vater. Brunner Glands. Common Bile Duct Neoplasms / epidemiology. Duodenal Diseases / epidemiology. Hamartoma / epidemiology. Jaundice, Obstructive / etiology
  • [MeSH-minor] Comorbidity. Digestive System Surgical Procedures. Dilatation, Pathologic. Duodenum / diagnostic imaging. Duodenum / pathology. Humans. Hypertrophy. Male. Middle Aged. Tomography, X-Ray Computed

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  • [Copyright] Copyright (c) 2007 S. Karger AG, Basel
  • (PMID = 18025786.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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85. Lee HG, You DD, Paik KY, Heo JS, Choi SH, Choi DW: Prognostic factors for primary duodenal adenocarcinoma. World J Surg; 2008 Oct;32(10):2246-52
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  • [Title] Prognostic factors for primary duodenal adenocarcinoma.
  • BACKGROUND: The aim of this study was to review the clinical features of primary duodenal adenocarcinoma (PDA) patients and to identify factors that influence survival.
  • [MeSH-major] Adenocarcinoma / mortality. Duodenal Neoplasms / mortality
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Prognosis. Survival Rate. Treatment Outcome

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  • (PMID = 18668288.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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86. Yasumoto T, Yamamoto T, Tomimaru Y, Ide Y, Matsunaga H, Ikeda N, Maruyama K, Yokouchi H, Okada K, Ota H, Kinuta M, Murata K: [Transcatheter arterial embolization for the continuous bleeding from duodenal carcinoma--a case report]. Gan To Kagaku Ryoho; 2007 Nov;34(12):2141-3
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  • [Title] [Transcatheter arterial embolization for the continuous bleeding from duodenal carcinoma--a case report].
  • We report a case of duodenal carcinoma with continuous bleeding that was successfully treated with transcatheter arterial embolization using gelatin sponge particles.
  • Upper gastrointestinal endoscopy revealed active bleeding from a duodenal tumor.
  • The biopsy of the specimens was made and showed duodenal adenocarcinoma.
  • The patient was considered to be inoperable because of the liver abscess and transcatheter arterial embolization of an anterior superior pancreaticoduodenal artery through an inferior pancreaticoduodenal artery was performed for the continuous bleeding from duodenal carcinoma not completely treated by endoscopic hemostasis or frequent transfusion.
  • Transcatheter arterial embolization for a continuous bleeding from duodenal carcinoma is a feasible and effective method as a noninvasive therapy when it is unabled to be treated by surgical resection or endoscopic therapy.
  • [MeSH-major] Arteries. Catheterization / methods. Duodenal Neoplasms / surgery. Duodenal Neoplasms / therapy. Embolization, Therapeutic. Hemorrhage / surgery

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  • (PMID = 18219925.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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87. Fishman MN, Garrett CR, Simon GR, Chiappori AA, Lush RM, Dinwoodie WR, Mahany JJ, Dellaportas AM, Cantor A, Gollerki A, Cohen MB, Sullivan DM: Phase I study of the taxane BMS-188797 in combination with carboplatin administered every 3 weeks in patients with solid malignancies. Clin Cancer Res; 2006 Jan 15;12(2):523-8
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  • Two radiographic partial responses were observed: one patient with duodenal adenocarcinoma and one patient with esophageal adenocarcinoma (time on study, 19 and 30 weeks, respectively).

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  • (PMID = 16428495.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BMS188797; 0 / Taxoids; BG3F62OND5 / Carboplatin
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88. Zhang T, Zhang F, Han Y, Gu Z, Zhou Y, Cheng Q, Zhu Y, Zhang C, Wang Y: A rat surgical model of esophageal metaplasia and adenocarcinoma-induced by mixed reflux of gastric acid and duodenal contents. Dig Dis Sci; 2007 Nov;52(11):3202-8
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  • [Title] A rat surgical model of esophageal metaplasia and adenocarcinoma-induced by mixed reflux of gastric acid and duodenal contents.
  • Recent clinical data have revealed that mixed reflux (MR) of gastric acid and duodenal contents frequently occurs in patients with gastroesophageal reflux disease and a progressive increase of MR occurs with increasing severity across gastroesophageal reflux disease.
  • Herein we report a novel rat surgical model in which esophageal metaplasia and adenocarcinoma develop as complications of MR.
  • Severe inflammatory and proliferative changes, high prevalence of esophageal metaplasia (78%), and adenocarcinoma (50%) were observed in the lower part of the esophagus of rats 20 weeks after surgery.
  • The resulting esophageal lesions resembled those described in humans and supported a progression from intestinal metaplasia to dysplasia and, ultimately, esophageal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / surgery. Duodenostomy / methods. Esophageal Neoplasms / surgery. Esophagostomy / methods. Esophagus / pathology. Gastroesophageal Reflux / complications. Jejunostomy / methods
  • [MeSH-minor] Animals. Disease Models, Animal. Disease Progression. Duodenum / secretion. Gastric Acid / secretion. Male. Metaplasia / etiology. Metaplasia / pathology. Metaplasia / surgery. Models, Anatomic. Rats. Rats, Sprague-Dawley

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  • (PMID = 17393326.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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89. Miller AD, Kramer JA, Lin KC, Knight H, Martinot A, Mansfield KG: Small intestinal adenocarcinoma in common marmosets (Callithrix jacchus). Vet Pathol; 2010 Sep;47(5):969-76
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  • [Title] Small intestinal adenocarcinoma in common marmosets (Callithrix jacchus).
  • Small intestinal adenocarcinomas are uncommon neoplasms that are rarely reported in nonhuman primates.
  • Herein the authors report the clinical, histologic, immunohistochemical, and molecular characteristics of small intestinal adenocarcinoma in 10 common marmosets (Callithrix jacchus).
  • Retrospective analysis of necropsy records revealed small intestinal carcinoma to be the most common neoplastic cause of morbidity and mortality in aged common marmosets.
  • Nine of 10 (90%) tumors arose within the proximal small intestine near the interface with the duodenum.
  • The tumors described in this population illustrate comparable features to human cases of small intestine carcinoma and may serve as a potential animal model for small intestinal carcinomas.

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  • (PMID = 20460447.001).
  • [ISSN] 1544-2217
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / T32 RR007000-35; United States / NCRR NIH HHS / RR / P51 RR000168-50; United States / NCRR NIH HHS / RR / T32 RR007000; United States / NCRR NIH HHS / RR / RR00168; United States / NCRR NIH HHS / RR / P51 RR000168; United States / NCRR NIH HHS / RR / K26 RR000168; United States / NCRR NIH HHS / RR / RR07000
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
  • [Other-IDs] NLM/ NIHMS235944; NLM/ PMC2955325
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90. Iso Y, Sawada T, Rokkaku K, Shimoda M, Kubota K: Ball-valve gastric tumor associated with anomalous junction of the pancreatico-biliary ductal system and a right-sided round ligament: report of a case. Surg Today; 2008;38(5):458-62
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  • Gastroscopy revealed a bleeding polypoid gastric tumor in the anterior wall of the stomach, herniating into the duodenum (ball-valve syndrome), and a Bormann type-2 tumor in the posterior wall.
  • [MeSH-major] Adenocarcinoma / surgery. Digestive System Abnormalities / complications. Polyps / surgery. Stomach Neoplasms / surgery

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  • (PMID = 18560972.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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91. Giorgadze TA, Peterman H, Baloch ZW, Furth EE, Pasha T, Shiina N, Zhang PJ, Gupta PK: Diagnostic utility of mucin profile in fine-needle aspiration specimens of the pancreas: an immunohistochemical study with surgical pathology correlation. Cancer; 2006 Jun 25;108(3):186-97
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  • Malignant transformation of the pancreatic ductal epithelium changes the expression of apomucins.
  • The goal of the current study was to determine an optimal immunohistochemical panel of mucin (MUC) antibodies that would allow the cytomorphologic distinction of pancreatic ductal adenocarcinoma and its differentiation from reactive/reparative processes and inadvertently sampled gastric and duodenal mucosa.
  • MUC2 was detected in mucosal goblets cells of the duodenum, MUC6 in Brunner glands, and MUC5AC in gastric foveolar cells.
  • CONCLUSIONS: The most optimal panel for the diagnosis of ductal adenocarcinoma in both the EUS-FNA specimens is a panel including MUC1/MUC2/MUC5AC, whereas a panel of all 4 antibodies (MUC1, 2, 5AC, and 6) will in addition aid in differentiating inadvertently sampled normal/reactive duodenal and gastric epithelium from neoplastic pancreatic tissue.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Child. Diagnosis, Differential. Duodenum / pathology. Female. Gastric Mucosa / pathology. Humans. Immunohistochemistry. Intestinal Mucosa / pathology. Male. Middle Aged


92. Yamamoto T, Fazio VW, Tekkis PP: Safety and efficacy of strictureplasty for Crohn's disease: a systematic review and meta-analysis. Dis Colon Rectum; 2007 Nov;50(11):1968-86
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  • The sites of strictureplasty were jejunum and/or ileum (94 percent), previous anastomosis (4 percent), duodenum (1 percent), and colon (1 percent).
  • Two patients developed adenocarcinoma at the site of previous jejunoileal strictureplasty.
  • The experience of duodenal or colonic strictureplasty was limited.
  • CONCLUSIONS: Strictureplasty is a safe and effective procedure for jejunoileal Crohn's disease, including ileocolonic recurrence, and it has the advantage of protecting against further small bowel loss.
  • However, the place for strictureplasty is less well defined in duodenal and colonic diseases.
  • [MeSH-minor] Adenocarcinoma / etiology. Anastomosis, Surgical. Colonic Neoplasms / etiology. Humans. Ileum / surgery. Jejunum / surgery. Recurrence. Short Bowel Syndrome / etiology. Treatment Outcome


93. Budiharto T, Haustermans K, Van Cutsem E, Van Steenbergen W, Topal B, Aerts R, Ectors N, Bielen D, Vanbeckevoort D, Goethals L, Verslype C: A phase I radiation dose-escalation study to determine the maximal dose of radiotherapy in combination with weekly gemcitabine in patients with locally advanced pancreatic adenocarcinoma. Radiat Oncol; 2008;3:30
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  • [Title] A phase I radiation dose-escalation study to determine the maximal dose of radiotherapy in combination with weekly gemcitabine in patients with locally advanced pancreatic adenocarcinoma.
  • The mean dose to the duodenum was significantly higher in the 54 Gy cohort (38.45 Gy vs. 51.82 Gy; p = 0.001).
  • Considering the good patient outcomes, there might be a role for the investigation of a fixed dose of gemcitabine and concurrent RT with small fractions (1.8 Gy/day) in borderline resectable or unresectable non-metastatic locally advanced pancreatic cancer.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / radiotherapy. Antimetabolites, Antineoplastic / administration & dosage. Deoxycytidine / analogs & derivatives. Pancreatic Neoplasms / drug therapy. Pancreatic Neoplasms / radiotherapy. Radiotherapy / methods
  • [MeSH-minor] Adult. Aged. Cohort Studies. Combined Modality Therapy. Female. Humans. Male. Maximum Tolerated Dose. Middle Aged. Neoplasm Metastasis

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  • (PMID = 18808686.001).
  • [ISSN] 1748-717X
  • [Journal-full-title] Radiation oncology (London, England)
  • [ISO-abbreviation] Radiat Oncol
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
  • [Other-IDs] NLM/ PMC2557003
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94. Hu JX, Miao XY, Zhong DW, Dai WD, Liu W, Hu W: Surgical treatment of primary duodenal adenocarcinoma. Hepatogastroenterology; 2006 Nov-Dec;53(72):858-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment of primary duodenal adenocarcinoma.
  • BACKGROUND/AIMS: Our purpose was to review the outcome of the patients with primary duodenal adenocarcinoma and determine factors influencing survival.
  • Based on symptomology, primary duodenal adenocarcinoma may be classified into three categories: icteric, obstructive and illusive.
  • A curative resection was performed in 28 of the 43 patients (65.1%), a conventional pancreatoduodenectomy in 11, segmental duodenal resection in 16 and gastroduodenectomy in 1.
  • Pancreaticoduodenectomy is usually required for tumors of the first and second portion of the duodenum.
  • Segmental resection may be appropriate for selected patients, especially for cancers of the distal duodenum.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / surgery. Duodenal Neoplasms / mortality. Duodenal Neoplasms / surgery

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  • (PMID = 17153441.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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95. Gyorffy H: [Study of claudins and prognostic factors in some gastrointestinal diseases]. Magy Onkol; 2009 Dec;53(4):377-83
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  • I. We explored the changes of CLDN expression in Barrett's esophagus and related adenocarcinoma.
  • Adenocarcinoma showed higher CLDN2 and -3 expression compared with normal and Barrett's epithelia.
  • The similar CLDN expression profile of Barrett's esophagus and adenocarcinoma supports their sequential development.
  • Tumors of small and large bowels exhibited higher CLDN2 expression when compared with normal epithelia.
  • Colorectal adenoma and adenocarcinoma could not be differentiated according to their CLDN profile.
  • Intestinal metaplasias of Barrett's esophagus and stomach show similar CLDN profile to small bowel epithelium.
  • III. Studies on duodenal mucosa in celiac disease in childhood demonstrated CLDN2 and -3 expression to be higher than in normal mucosa.
  • The expression was significantly higher in the distal part of the duodenum samples.
  • This and the serious histological findings suggest that the distal duodenum is more adequate for biopsy testing.
  • [MeSH-minor] Adenocarcinoma / metabolism. Adolescent. Adult. Aged. Aged, 80 and over. Barrett Esophagus / metabolism. Carcinoma, Squamous Cell / metabolism. Child. Child, Preschool. Claudin-3. Female. Fluorescent Antibody Technique. Gastrointestinal Stromal Tumors / metabolism. Gene Expression Regulation, Neoplastic. Hemangiosarcoma / metabolism. Humans. Immunohistochemistry. Leiomyosarcoma / metabolism. Male. Membrane Proteins / metabolism. Middle Aged. Predictive Value of Tests. Prognosis. RNA, Messenger / metabolism. Risk Factors. Young Adult

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  • (PMID = 20071310.001).
  • [ISSN] 0025-0244
  • [Journal-full-title] Magyar onkologia
  • [ISO-abbreviation] Magy Onkol
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CLDN3 protein, human; 0 / Claudin-3; 0 / Claudins; 0 / Membrane Proteins; 0 / RNA, Messenger
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96. Solej M, D'Amico S, Brondino G, Ferronato M, Nano M: Primary duodenal adenocarcinoma. Tumori; 2008 Nov-Dec;94(6):779-86
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  • [Title] Primary duodenal adenocarcinoma.
  • AIMS AND BACKGROUND: Primary duodenal adenocarcinoma is a rare tumor with a poorly defined natural history and prognostic factors.
  • It presents with nonspecific symptoms, and for this reason the diagnosis is often delayed.
  • It is a serious problem for the surgeon because of the difficulty in obtaining an early diagnosis and standardizing basic tenets for an appropriate surgical approach.
  • METHODS AND STUDY DESIGN: A bibliographic search was carried out on the main search engines to find studies regarding duodenal adenocarcinoma, published in English, from January 1992 to January 2007.
  • Hopefully, an early diagnosis will correlate with improved long-term survival.
  • [MeSH-major] Adenocarcinoma / pathology. Duodenal Neoplasms / pathology

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  • (PMID = 19267092.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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97. Halfdanarson TR, McWilliams RR, Donohue JH, Quevedo JF: A single-institution experience with 491 cases of small bowel adenocarcinoma. Am J Surg; 2010 Jun;199(6):797-803
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A single-institution experience with 491 cases of small bowel adenocarcinoma.
  • BACKGROUND: The optimal treatment of small bowel adenocarcinoma is unknown.
  • METHODS: The records of 491 patients with small bowel adenocarcinoma diagnosis between 1970 and 2005 were reviewed for patient and tumor characteristics, treatment effects, and survival.
  • RESULTS: The median age at diagnosis was 62 years.
  • The most common tumor locations were the duodenum (57%), jejunum (29%), and ileum (10%).
  • CONCLUSIONS: The prognosis of patients with small bowel adenocarcinoma is poor.
  • [MeSH-major] Adenocarcinoma / surgery. Intestinal Neoplasms / surgery. Intestine, Small
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Chi-Square Distribution. Female. Humans. Male. Middle Aged. Neoplasm Staging. Neoplasm, Residual. Prognosis. Proportional Hazards Models. Risk Factors. Sex Factors. Statistics, Nonparametric. Survival Rate. Treatment Outcome

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  • [Copyright] Published by Elsevier Inc.
  • (PMID = 20609724.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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98. Kang SM, Murata A, Tendou M, Tezuka K, Nishino Y: [A case report of primary duodenal adenocarcinoma with marked lymph node metastases responding to chemotherapy with S-1 plus CDDP combination]. Gan To Kagaku Ryoho; 2009 Sep;36(9):1569-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case report of primary duodenal adenocarcinoma with marked lymph node metastases responding to chemotherapy with S-1 plus CDDP combination].
  • The patient was a 48-year-old female who underwent combination chemotherapy of S-1 plus CDDP after diagnosis of primary duodenal adenocarcinoma with marked lymph node metastases.
  • This case suggests that the combination of S-1 and CDDP may be an effective regimen for advanced primary duodenal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Duodenal Neoplasms / drug therapy. Lymphatic Metastasis

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  • (PMID = 19755836.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents; 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; Q20Q21Q62J / Cisplatin
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99. Li Y, Wo JM, Su RR, Ray MB, Martin RC: Alterations in manganese superoxide dismutase expression in the progression from reflux esophagitis to esophageal adenocarcinoma. Ann Surg Oncol; 2007 Jul;14(7):2045-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alterations in manganese superoxide dismutase expression in the progression from reflux esophagitis to esophageal adenocarcinoma.
  • BACKGROUND: Comprehensive understanding of the basic mechanisms in the progression of esophagitis, Barrett esophagus (BE), and esophageal adenocarcinoma (EAC) is urgently needed to develop a management strategy for an effective screening of BE and management of EAC.
  • [MeSH-major] Adenocarcinoma / metabolism. Barrett Esophagus / metabolism. Esophageal Neoplasms / metabolism. Esophagitis, Peptic / metabolism. Superoxide Dismutase / biosynthesis
  • [MeSH-minor] Anastomosis, Surgical. Animals. Apoptosis. Cell Proliferation. Deoxyguanosine / analogs & derivatives. Deoxyguanosine / biosynthesis. Disease Models, Animal. Disease Progression. Duodenum / surgery. Epithelial Cells / metabolism. Esophagus / surgery. Immunohistochemistry. Oxidative Stress. Precancerous Conditions / metabolism. Rats. Rats, Sprague-Dawley

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  • (PMID = 17473952.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 88847-89-6 / 8-oxo-7-hydrodeoxyguanosine; EC 1.15.1.1 / Superoxide Dismutase; G9481N71RO / Deoxyguanosine
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100. Parés D, García-Ruiz A, Biondo S, Blanco I, Llort G, Arriol E, de Oca J, del Río C, Osorio A, Navarro M, Martí-Ragué J, Jaurrieta E: [Current status of follow-up of the upper digestive tract in familial adenomatous polyposis]. Gastroenterol Hepatol; 2006 Jan;29(1):15-20
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  • Although the most commonly involved region in this disease is the colorectal area, it is well known that adenomas can also develop in the upper gastrointestinal tract, mainly in the periampullary area of the duodenum.
  • Because of the possibility of malignant transformation of these polyps, adequate monitoring is required, even though the optimal follow-up schedule has not yet been defined.
  • In the present article, we report a case of a gastric adenocarcinoma detected during the follow-up of a patient diagnosed with FAP, as well as a review of the literature on this subject.
  • The first endoscopy in patients with FAP should be performed at the age of 20 years or at diagnosis.
  • [MeSH-major] Adenocarcinoma / etiology. Adenomatous Polyposis Coli / complications. Stomach Neoplasms / etiology






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