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Using matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS), the plasma protein profile was determined in nine stage IV CRC patients (study group) and nine clean-colon healthy subjects (control group).

[MeSH-major] Adenocarcinoma / blood. Biomarkers, Tumor / analysis. Colorectal Neoplasms / blood. Proteomics / methods. Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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(PMID = 17117375.001).

[ISSN] 1076-5174

[Journal-full-title] Journal of mass spectrometry : JMS

[ISO-abbreviation] J Mass Spectrom

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Blood Proteins

   

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BACKGROUND: In a province-wide audit of patients undergoing treatment for rectal cancer in British Columbia in 1996, the 4-year rate of pelvic recurrence for stage 3 rectal cancer was 27%.

Relative to the 1996 cohort, there was a decreasing trend in 2-year overall pelvic recurrence rates in the 2003/04 cohort (9.6% v. 6.9%) and a significant decrease in recurrence among patients with stage 3 cancers (18.2% v. 9.2%; p = 0.020).

[MeSH-major] Adenocarcinoma / therapy. Antineoplastic Agents / therapeutic use. Colectomy / methods. Rectal Neoplasms / therapy

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[Cites] Cochrane Database Syst Rev. 2000;(2):CD000125 [10796491.001]

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[CommentIn] Can J Surg. 2010 Aug;53(4):222-4 [20646394.001]

(PMID = 20646395.001).

[ISSN] 1488-2310

[Journal-full-title] Canadian journal of surgery. Journal canadien de chirurgie

[ISO-abbreviation] Can J Surg

[Language] eng

[Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Canada

[Chemical-registry-number] 0 / Antineoplastic Agents

[Other-IDs] NLM/ PMC2912013

   

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Nine tumors were located in the rectum, two in the sigmoid, and each one in the transverse colon and cecum, respectively.

All patients were advanced at the time of diagnosis, with AJCC TNM staging: stage IIIB (n=2), stage IIIC (n=3), and stage IV (n=8).

Five patients who received chemotherapy showed median survival of 32 months (stage III) and 17.5 months (stage IV), whereas other five patients without chemotherapy died with a median survival of 6.2 months.

[MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Biomarkers, Tumor / immunology. Biopsy. Chromogranin A / analysis. Chromogranin A / immunology. Drug Therapy, Combination. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. Retrospective Studies. Sigmoid Neoplasms / drug therapy. Sigmoid Neoplasms / mortality. Sigmoid Neoplasms / pathology. Synaptophysin / analysis. Synaptophysin / immunology

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(PMID = 16929153.001).

[ISSN] 1598-9992

[Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi

[ISO-abbreviation] Korean J Gastroenterol

[Language] kor

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Korea (South)

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromogranin A; 0 / Synaptophysin

   

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Stage IV endometriosis with extensive pelvic involvement was found in two patients.

Intraoperatively, the endometriotic lesions involved the ovaries (all cases); Cul de sac (four cases); urinary bladder (two cases); sigmoid colon, hemidiaphragms, and uterine vessels (one case each).

The endometriotic lesions were associated with uterine leiomyomas (two patients) and adenocarcinoma of the vagina (one patient).

One patient had recurred with metastatic adenocarcinoma of the vault.

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(PMID = 18575828.001).

[ISSN] 1219-4956

[Journal-full-title] Pathology oncology research : POR

[ISO-abbreviation] Pathol. Oncol. Res.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Netherlands

   

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Here, we report on the prevalence and potential clinical significance of fascin expression in relation to the progression of colorectal adenocarcinoma and to tumor cell proliferation as measured by Ki67 index.

In the clinically-annotated tumors, fascin immunoreactivity was more common in tumors located in the proximal colon (p = 0.009), but was not associated with age, gender, or TNM stage.

Patients with stage III/IV adenocarcinomas (n = 62) with strong fascin immunoreactivity had a worse prognosis than patients with low or absent fascin, (3-year overall survival of 11% versus 43% for fascin-negative patients; p = 0.023).

Strong and diffuse expression was seen in a subset of advanced colorectal adenocarcinomas that correlated with shorter survival in stage III and IV patients.

[MeSH-major] Adenocarcinoma / genetics. Adenoma / genetics. Carrier Proteins / biosynthesis. Colorectal Neoplasms / genetics. Gene Expression Regulation, Neoplastic / physiology. Microfilament Proteins / biosynthesis

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[ErratumIn] BMC Cancer. 2011;11:488

(PMID = 17029629.001).

[ISSN] 1471-2407

[Journal-full-title] BMC cancer

[ISO-abbreviation] BMC Cancer

[Language] eng

[Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Carrier Proteins; 0 / Microfilament Proteins; 146808-54-0 / fascin

[Other-IDs] NLM/ PMC1615879

   

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The lesion was judged to be P1, SE, H0, N2 and Stage IV and the patient was managed on a regular schedule as an outpatient.

A fiber optic examination of the sigmoid colon detected an ulcerous lesion with a hemorrhage at the anterior rectal wall.

A biopsy revealed the lesion to be Group V poorly differentiated adenocarcinoma.

After 3 courses of this regimen, a fiber optic examination of the colon conducted in February 2005 no longer detected the rectal tumor, leaving only a cicatrix.

[MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / secondary. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Rectal Diseases / drug therapy. Rectal Neoplasms / drug therapy. Rectal Neoplasms / secondary. Stomach Neoplasms / pathology. Stomach Neoplasms / surgery

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(PMID = 16315933.001).

[ISSN] 0385-0684

[Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy

[ISO-abbreviation] Gan To Kagaku Ryoho

[Language] jpn

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Japan

[Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents; 0 / Drug Combinations; 0 / Pyridines; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; Q20Q21Q62J / Cisplatin

   

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In a multivariate analysis, T-stage, N-stage, and tumor location were independent risk factors for CRM.

T-stage, N-stage, and CRM were risk factors for LR and age, T-stage, N-stage, CRM, and distance of the inferior tumor margin to the anal verge for OS.

CONCLUSION: Age, T-stage, N-stage, CRM, distance of the tumor to the anal verge, and tumor location were independent risk factors for adverse outcome in patients treated with an APR for low rectal cancer.

[MeSH-major] Adenocarcinoma / surgery. Digestive System Surgical Procedures / methods. Postoperative Complications. Rectal Neoplasms / surgery

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(PMID = 17592295.001).

[ISSN] 0003-4932

[Journal-full-title] Annals of surgery

[ISO-abbreviation] Ann. Surg.

[Language] eng

[Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Other-IDs] NLM/ PMC1899206

   

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The localization of each PGES and COX-2 protein was examined by immunohistochemistry in 155 surgical resections and correlated to clinicopathological factors and patient prognosis. mPGES-1 mRNA and protein levels were significantly higher in CRC than in paired normal tissues. mPGES-1 immunoreactivity localized in cancer cells in 43% of cases. mPGES-2 immunoreactivity was significantly more pronounced in cancer cells than in adjacent normal epithelium in 36% of cases. cPGES immunoreactivity was homogeneous in cancer cells and thus determined constitutive. mPGES-1 and mPGES-2 correlated with significantly worse prognosis in stage I-III patients.

[MeSH-major] Adenocarcinoma / enzymology. Colorectal Neoplasms / enzymology. Intramolecular Oxidoreductases / metabolism. Microsomes / enzymology

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(PMID = 19412621.001).

[ISSN] 1432-2307

[Journal-full-title] Virchows Archiv : an international journal of pathology

[ISO-abbreviation] Virchows Arch.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Germany

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Isoenzymes; 0 / RNA, Messenger; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 5.3.- / Intramolecular Oxidoreductases; EC 5.3.99.3 / PTGES protein, human; EC 5.3.99.3 / PTGES2 protein, human; EC 5.3.99.3 / Prostaglandin-E Synthases

   

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METHODS: Tissue samples of primary tumors and metastatic lymph nodes from 150 patients undergoing intentionally curative surgical resections for colorectal adenocarcinoma were immunohistochemically examined for vascular endothelial growth factor-C, cyclooxygenase-2, and CD34 expressions.

A significant correlation was found between the expression scores of vascular endothelial growth factor-C and cyclooxygenase-2 (P < 0.0001), and both also were correlated to microvessels density and several clinicopathologic parameters, including primary tumor size, lymph node metastasis, lymphatic invasion, and TNM stage.

[MeSH-major] Adenocarcinoma / metabolism. Colorectal Neoplasms / metabolism. Cyclooxygenase 2 / metabolism. Lymph Nodes / metabolism. Membrane Proteins / metabolism. Vascular Endothelial Growth Factor C / metabolism

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(PMID = 16474989.001).

[ISSN] 0012-3706

[Journal-full-title] Diseases of the colon and rectum

[ISO-abbreviation] Dis. Colon Rectum

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Antigens, CD34; 0 / Membrane Proteins; 0 / Vascular Endothelial Growth Factor C; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human

   

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[Title] The clinical significance of fat clearance lymph node harvest for invasive rectal adenocarcinoma following neoadjuvant therapy.

N1 and N2 stages were regarded as N+ stage.

In the nonneoadjuvant group, there was no significant difference in the number of positive lymph nodes (0.5 +/- 0.2 vs. 1.0 +/- 0.3, P = 0.235), N stage (P = 0.265), or patients with N+ stage (7/31 vs. 16/49, P = 0.332) between the two methods, even though the total lymph node harvest was significantly increased by use of the fat clearance method (9.6 +/- 1.3 vs. 27.6 +/- 2.5, P < 0.001).

In contrast, the total lymph node retrieval (5.2 +/- 0.6 vs. 20.4 +/- 1.2, P < 0.001), number of positive lymph nodes (0.4 +/- 0.2 vs. 1.2 +/- 0.3, P = 0.007), N stage (P = 0.005), and patients with N+ stage (6/51 vs. 34/106, P = 0.006) were all increased by fat clearance in the neoadjuvant group.

Moreover, the number of patients with N+ stage was stratified by T stage level (T0-T4) to eliminate the background bias, and the results were confirmed.

[MeSH-major] Adenocarcinoma / pathology. Lymph Node Excision / methods. Rectal Neoplasms / pathology

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(PMID = 19966611.001).

[ISSN] 1530-0358

[Journal-full-title] Diseases of the colon and rectum

[ISO-abbreviation] Dis. Colon Rectum

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] United States

   

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Microarray analysis on pooled samples has previously identified ZDHHC9 (DHHC9) to be upregulated in colon adenocarcinoma compared to normal colon mucosa.

Immunohistochemical analysis was performed on 60 colon adenocarcinomas, previously analysed on microarrays, as well as on tissue microarrays with 40 stage I-IV tumours and 46 tumours from different organ sites.

In conclusion, DHHC9 is a gastrointestinal-related protein highly expressed in MSS colon tumours.

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(PMID = 17519897.001).

[ISSN] 0007-0920

[Journal-full-title] British journal of cancer

[ISO-abbreviation] Br. J. Cancer

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / DNA, Neoplasm; 0 / RNA, Neoplasm; EC 2.3.- / Acyltransferases; EC 2.3.1.- / ZDHHC9 protein, human

[Other-IDs] NLM/ PMC2359975

   

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[Title] Distribution of a single nucleotide polymorphism of insulin-like growth factor-1 in colorectal cancer patients and its association with mucinous adenocarcinoma.

RESULTS: Young CRC patients had a higher frequency of advanced disease (58.7%) and mucinous adenocarcinoma (20%) than old CRC patients.

Other clinicopathological factors including tumor location, differentiation, lymphovascular invasion, and TNM stage were not associated with the AA genotype of IGF-1.

CONCLUSIONS: Older patients had a higher frequency of the AA genotype of IGF-1(-2995 C/A), while younger patients more often had advanced disease and mucinous adenocarcinoma.

[MeSH-major] Adenocarcinoma, Mucinous / genetics. Colorectal Neoplasms / genetics. Insulin-Like Growth Factor I / genetics. Polymorphism, Single Nucleotide

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(PMID = 21161940.001).

[ISSN] 1724-6008

[Journal-full-title] The International journal of biological markers

[ISO-abbreviation] Int. J. Biol. Markers

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 67763-96-6 / Insulin-Like Growth Factor I

   

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Pathological examination determined International Federation of Gynecology and Obstetrics (FIGO) stage IIIc MMMT of the right fallopian tube.

Of note, multiple tumoral nodules were attached to the sigmoid colon.

The tumor attached to the sigmoid colon had shrunk by 60% after chemotherapy.

[MeSH-minor] Adenocarcinoma / pathology. Aged. Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Humans. Ovariectomy

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[Cites] Gynecol Oncol. 1992 Oct;47(1):114-24 [1330846.001]

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(PMID = 18946759.001).

[ISSN] 1341-9625

[Journal-full-title] International journal of clinical oncology

[ISO-abbreviation] Int. J. Clin. Oncol.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Japan

[Chemical-registry-number] BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel

   

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In this study comparing normal colon to colorectal cancer by proteomics, hnRNP K was identified as being overexpressed in this type of cancer.

In normal colon hnRNP K was exclusively nuclear whereas in colorectal cancer the protein localised both in the cytoplasm and the nucleus.

There were significant increases in both nuclear (P=0.007) and cytoplasmic (P=0.001) expression of hnRNP K in Dukes C tumours compared with early stage tumours.

[MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / analysis. Colorectal Neoplasms / metabolism. Ribonucleoproteins / biosynthesis

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[Cites] EMBO J. 1994 Mar 15;13(6):1476-81 [8137829.001]

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(PMID = 16953238.001).

[ISSN] 0007-0920

[Journal-full-title] British journal of cancer

[ISO-abbreviation] Br. J. Cancer

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ribonucleoproteins; 146410-60-8 / HNRNPK protein, human

[Other-IDs] NLM/ PMC2360539

   

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[Title] CD133 and nuclear beta-catenin: the marker combination to detect high risk cases of low stage colorectal cancer.

Nuclear beta-catenin and CD133 are linked with two hallmarks of colon cancer, wingless-type mouse mammary tumour virus integration site (WNT)-pathway dysregulation and colon cancer stem cells (Co-CSCs), respectively.

Herein, we investigated the expression of these markers on serial sections of 162 stage IIA colonic adenocarcinomas.

Moreover, we show that their combined evaluation can identify colon cancer cases with vastly reduced survival (hazard ratio (HR) 13.4, 95% confidence interval (CI): 4.7-38.2) and a high risk of tumour progression (HR 6.8, 95%CI: 3.1-15.0).

In conclusion, the independence of these markers may on the one hand have implications for their presumed value to identify Co-CSCs; on the other hand it allows their combined analysis to become a powerful tool to identify high risk cases of stage IIA colon cancer.

[MeSH-major] Adenocarcinoma / metabolism. Antigens, CD / analysis. Biomarkers, Tumor / analysis. Colorectal Neoplasms / metabolism. Glycoproteins / analysis. Peptides / analysis. beta Catenin / analysis

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(PMID = 19403300.001).

[ISSN] 1879-0852

[Journal-full-title] European journal of cancer (Oxford, England : 1990)

[ISO-abbreviation] Eur. J. Cancer

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Chemical-registry-number] 0 / AC133 antigen; 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / Glycoproteins; 0 / Peptides; 0 / beta Catenin

   

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Because recurrent adenocarcinoma of the colon and rectum (CRC) can still be treated with acceptable 5-year survival rates, tumor surveillance plays an important role.

Only in cases where early stage CRC was been completely resected no schematic surveillance must take place.

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(PMID = 18622956.001).

[ISSN] 0040-5930

[Journal-full-title] Therapeutische Umschau. Revue thérapeutique

[ISO-abbreviation] Ther Umsch

[Language] ger

[Publication-type] English Abstract; Journal Article

[Publication-country] Switzerland

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen

   

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[Title] Management and prognosis of colon cancer in patients with intestinal obstruction or peritonitis: a French population-based study.

BACKGROUND: In spite of recent advances in our knowledge of tumor biology and therapy, the management and prognosis of patients with colon cancer (CC) revealed by intestinal obstruction or peritonitis (IOP) are not well defined.

The primary independent negative prognostic factor in multivariate analysis was the presence of nodal or distant metastases (Dukes' stage D, p=0.0001), followed by lack of chemotherapy (p=0.008), initial treatment in non-specialized hospitals (p=0.01), onset with IOP (p=0.02), low-volume surgeons (p=0.02).

[MeSH-major] Adenocarcinoma / therapy. Colonic Neoplasms / therapy. Intestinal Obstruction / etiology. Peritonitis / etiology

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(PMID = 15917717.001).

[ISSN] 1234-1010

[Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research

[ISO-abbreviation] Med. Sci. Monit.

[Language] eng

[Publication-type] Journal Article; Multicenter Study

[Publication-country] Poland

   

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[Title] Asymptomatic ileal adenocarcinoma in the setting of undiagnosed Crohn's disease.

Examination of the colon was normal.

The biopsy of the ileal mass was consistent with an adenocarcinoma arising from the terminal ileum.

Findings were consistent with ileal adenocarcinoma in the setting of Crohn's disease.

The pathology was stage 1 adenocarcinoma.

This is a unique case in that on a screening colonoscopy, a favorable ileal adenocarcinoma was discovered in the setting of asymptomatic, undiagnosed ileal Crohn's disease in a patient whose father had Crohn's disease diagnosed postmortem.

[MeSH-major] Adenocarcinoma / diagnosis. Crohn Disease / diagnosis. Ileal Neoplasms / diagnosis

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(PMID = 18698685.001).

[ISSN] 1007-9327

[Journal-full-title] World journal of gastroenterology

[ISO-abbreviation] World J. Gastroenterol.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] China

[Other-IDs] NLM/ PMC2738795

   

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METHOD: Prospective registration of all operated patients as well as inclusions (curative resection, stage II or III disease, <or= 75 years, clean colon and exclusions of the individual patients in eight participating departments.

[MeSH-major] Adenocarcinoma / surgery. Colonic Neoplasms / surgery. Patient Selection. Rectal Neoplasms / surgery

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(PMID = 19708095.001).

[ISSN] 1463-1318

[Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

[ISO-abbreviation] Colorectal Dis

[Language] eng

[Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial

[Publication-country] England

   

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SUMMARY BACKGROUND DATA: The incidence of rectal cancer increases with older age, and localized disease can be curatively treated with stage-appropriate radical surgery.

METHODS: Patients with localized rectal adenocarcinoma were identified in the Surveillance, Epidemiology, and End Results database (1991-2002).

Each half-decade increase in age > or =70 years was associated with a 37% increase in the relative risk (RR) for cancer-related mortality (RR = 1.37; 95% confidence interval [CI], 1.33-1.42); decreased receipt of cancer-directed surgery (odds ratio [OR] = 0.56; 95% CI, 0.36-0.63); more local excision and less radical surgery (OR = 0.76; 95% CI, 0.72-0.81); less radiotherapy (OR = 0.64; 95% CI, 0.61-0.67); and greater likelihood of N0 pathologic stage classification (OR = 1.10; 95% CI, 1.05-1.15) (P < 0.0001 for each factor).

[MeSH-major] Adenocarcinoma / epidemiology. Rectal Neoplasms / epidemiology

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[Cites] Ann Surg. 2000 Mar;231(3):345-51 [10714627.001]

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(PMID = 17667499.001).

[ISSN] 0003-4932

[Journal-full-title] Annals of surgery

[ISO-abbreviation] Ann. Surg.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Other-IDs] NLM/ PMC1933551

   

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BACKGROUND: We present a case of recurrent colon cancer detected by routine, annual Papanicolaou screening.

CASE: A 59-year-old African American woman who had been treated for T2N0M0 (stage II, Dukes A) colon cancer 2 years before to presentation had a Pap smear showing a high-grade squamous intraepithelial lesion with a normal cervical biopsy result.

Because of this discrepancy, a loop electrosurgical excision procedure and endocervical curettage were performed and showed atypical glandular cells suspicious for adenocarcinoma.

Subsequent colonoscopy showed recurrent adenocarcinoma of the colon.

The patient underwent an en-block total abdominal hysterectomy and anterior-perineal resection showing invasion of recurrent colon cancer into the uterus and cervix.

CONCLUSION: In patients with a history of extrauterine adenocarcinoma, abnormal Pap screening may indicate recurrent or metastatic carcinoma.

[MeSH-major] Adenocarcinoma / diagnosis. Colorectal Neoplasms / diagnosis. Diagnostic Tests, Routine. Neoplasm Recurrence, Local / diagnosis. Papanicolaou Test. Uterine Neoplasms / diagnosis. Vaginal Smears

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(PMID = 16205196.001).

[ISSN] 1089-2591

[Journal-full-title] Journal of lower genital tract disease

[ISO-abbreviation] J Low Genit Tract Dis

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

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OBJECTIVE: To evaluate survival and prognostic factors in a consecutive series of colon cancer patients from a defined city population in Norway.

METHOD: All patients with adenocarcinoma of the colon diagnosed between 1993 and 2000 were registered prospectively.

Tumour location in the transverse colon, splenic flexure and descending colon (OR = 1.8), emergency operation (OR = 1.7), TNM stage (OR = 1.8-2.9), blood transfusion of more than two units (OR = 1.8) and age (OR = 4.0-7.1) were independent negative prognostic factors.

CONCLUSION: Colon cancer located in the transverse and descending colon is associated with poor prognosis.

[MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / surgery. Colectomy / methods. Colonic Neoplasms / mortality. Colonic Neoplasms / surgery. Neoplasm Recurrence, Local / pathology

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(PMID = 17672872.001).

[ISSN] 1463-1318

[Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

[ISO-abbreviation] Colorectal Dis

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

   

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[Title] Colon cancer survival is associated with decreasing ratio of metastatic to examined lymph nodes.

PATIENTS AND METHODS: We analyzed data from Intergroup trial 0089 of adjuvant chemotherapy for stage II and III patients with colon cancer, in which all patients received fluorouracil-based therapy.

Covariates included in the models were age, sex, tumor stage, grade, histology, number of positive LNs, number of LNs removed, and LNR.

[MeSH-major] Adenocarcinoma / therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colonic Neoplasms / therapy. Lymphatic Metastasis / pathology

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(PMID = 16314630.001).

[ISSN] 0732-183X

[Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology

[ISO-abbreviation] J. Clin. Oncol.

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] United States

   

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[Title] Failure to complete adjuvant chemotherapy is associated with adverse survival in stage III colon cancer patients.

Two recent North American studies have shown that completion of 5-fluorouracil (5FU)-based adjuvant chemotherapy is a major prognostic factor for the survival of elderly stage III colon cancer patients.

The study cohort comprised 851 stage III colon cancer patients treated by surgery alone and 461 who initiated the Mayo chemotherapy regime.

The current and previous studies demonstrate the importance of completing adjuvant 5-FU-based chemotherapy for colon cancer.

[MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / mortality. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Colonic Neoplasms / drug therapy. Colonic Neoplasms / mortality

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[Cites] J Clin Oncol. 2002 Sep 1;20(17):3605-16 [12202661.001]

[Cites] J Clin Oncol. 2002 Mar 15;20(6):1491-8 [11896096.001]

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(PMID = 17299387.001).

[ISSN] 0007-0920

[Journal-full-title] British journal of cancer

[ISO-abbreviation] Br. J. Cancer

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil

[Other-IDs] NLM/ PMC2360063

   

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All underwent transhiatal esophagectomy and gastric tube or colon was used as the conduit to restore continuity.

The TNM staging were stage I, IIa, IIb, III and IV in zero (0), 5 (11%), 10 (22%), 24 (57.8%) and 3 (7.1%) respectively.

The frequency of complications is lower as compared to transthoracic approach and the early stage of presentation can lead to high 5-year survival ratios.

[MeSH-major] Adenocarcinoma / surgery. Carcinoma, Squamous Cell / surgery. Esophageal Neoplasms / surgery. Esophagectomy / methods

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(PMID = 19576147.001).

[ISSN] 1022-386X

[Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

[ISO-abbreviation] J Coll Physicians Surg Pak

[Language] eng

[Publication-type] Journal Article

[Publication-country] Pakistan

   

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[Title] Two-port hand-assisted laparoscopic surgery for the 2-stage treatment of a complete bowel obstruction by left colon cancer: a case report.

Since a bowel obstruction by left colon cancer was suspected due to a marked dilation of the transverse colon, she was referred to our hospital.

On admission, an enema disclosed a complete obstruction at the splenic flexure of the colon.

An emergency operation was performed, and a temporary loop colostomy was fashioned on the left side of the transverse colon within the range of resection for 2-stage radical surgery.

The histological diagnosis was Type 2 circumferential well-differentiated adenocarcinoma with local peritoneal dissemination.

Our experience suggests that 2-stage surgery combined with 2P-HALS is applicable even to a large obstructing left colon cancer.

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(PMID = 18357370.001).

[ISSN] 1021-335X

[Journal-full-title] Oncology reports

[ISO-abbreviation] Oncol. Rep.

[Language] eng

[Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Greece

   

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METHODS: This prospective study from the Norwegian Rectal Cancer Project includes all 2,283 patients younger than aged 70 years with adenocarcinoma of the rectum from November 1993 to December 1999.

RESULTS: Patients younger than aged 40 years had significantly higher frequencies of poorly differentiated tumors (27 vs. 12-16 percent; P = 0.014), N2-stage (37 vs. 13-18 percent; P = 0.001), and distant metastases (38 vs. 19-24 percent; P = 0.019) compared with older patients.

CONCLUSIONS: Patients younger than aged 40 years had a more advanced stage at the time of diagnosis and poor prognosis compared with older patients.

[MeSH-major] Adenocarcinoma / therapy. Rectal Neoplasms / therapy

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(PMID = 16741599.001).

[ISSN] 0012-3706

[Journal-full-title] Diseases of the colon and rectum

[ISO-abbreviation] Dis. Colon Rectum

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] United States

   

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[Title] Impaired CD95 expression predisposes for recurrence in curatively resected colon carcinoma: clinical evidence for immunoselection and CD95L mediated control of minimal residual disease.

BACKGROUND: Loss of CD95 expression in tumour cells occurs frequently in colon carcinoma and may be associated with disease progression.

AIMS: We aimed at further exploring the functional role and prognostic significance of the CD95/CD95L death inducing system in colon carcinomas.

PATIENTS AND METHODS: CD95 and CD95L expression was examined by immunohistochemistry in 128 R0 resected UICC (International Union against Cancer) stage II/III colon carcinomas and correlated with disease free survival.

Tumour infiltrating lymphocytes (TIL) were the major source of CD95L in colon carcinomas.

Moreover, a high rate of CD95L+TIL correlated with prolonged disease free survival in patients with UICC stage II (p = 0.05) but not in those with stage III.

CONCLUSIONS: Loss of CD95 in tumour cells may be an independent prognostic factor in colon carcinomas.

The CD95L counterattack is not a relevant feature in colon carcinoma but CD95L+TIL may contribute to tumour control in the early stages of the disease, exerting a concurrent selection pressure in the direction of CD95 abrogation/resistance.

[MeSH-major] Adenocarcinoma / immunology. Antigens, CD95 / metabolism. Biomarkers, Tumor / metabolism. Colonic Neoplasms / immunology. Membrane Glycoproteins / metabolism

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[Cites] Hum Pathol. 1999 Nov;30(11):1309-13 [10571510.001]

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(PMID = 15831912.001).

[ISSN] 0017-5749

[Journal-full-title] Gut

[ISO-abbreviation] Gut

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Antigens, CD95; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / FASLG protein, human; 0 / Fas Ligand Protein; 0 / Ligands; 0 / Membrane Glycoproteins

[Other-IDs] NLM/ PMC1774512

   

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[Title] [Adjuvant chemotherapy for colon cancer].

BACKGROUND: Radical resection is the main treatment for adenocarcinoma of the colon.

The background for adjuvant chemotherapy of colon cancer is presented.

RESULTS AND INTERPRETATION: Cure rates after curative resections of colon cancer (stage III) are improved by about 12% if patients are treated with adjuvant chemotherapy with oxaliplatin combined with 5-fluoruracil and folinat (or capecitabine) for 6 months.

Certain subgroups of stage II (Dukes' stage B) are also likely to benefit from adjuvant chemotherapy.

[MeSH-major] Adenocarcinoma / drug therapy. Colonic Neoplasms / drug therapy

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(PMID = 18049502.001).

[ISSN] 0807-7096

[Journal-full-title] Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række

[ISO-abbreviation] Tidsskr. Nor. Laegeforen.

[Language] nor

[Publication-type] English Abstract; Journal Article; Review

[Publication-country] Norway

[Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Antineoplastic Agents

[Number-of-references] 35

   

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[Title] Mucinous carcinoma of the colon and rectum in Phramongkutklao Hospital.

OBJECTIVE: The objective of the present study was to compare the clinicopathological significance between mucinous carcinoma and nonmucinous adenocarcinoma.

MATERIAL AND METHOD: Patients with carcinoma of the colon and rectum who had the first operation in the Department of Surgery, Phramongkutklao Hospital between 1999 and 2004 were included in the present study.

There was no difference in sex distribution, location of tumors, depth of invasion, lymph node involvement, distant metastasis, TNM stage, lymphatic invasion, vascular invasion, perineural invasion, peritoneal seeding, curability, positive microscopic margin, and adhesion to the surrounding structure.

CONCLUSION: Colorectal mucinous carcinoma had no clinicopathological difference from nonmucinous adenocarcinoma of colon and rectum.

[MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma, Mucinous / pathology. Colonic Neoplasms / pathology. Rectal Neoplasms / pathology

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(PMID = 16583577.001).

[ISSN] 0125-2208

[Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet

[ISO-abbreviation] J Med Assoc Thai

[Language] eng

[Publication-type] Journal Article

[Publication-country] Thailand

   

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No significant difference in occurrence of micrometastasis was observed among tumors of different stage.

[MeSH-major] Adenocarcinoma / pathology. Mesentery / pathology. Neoplasm Recurrence, Local / pathology. Rectal Neoplasms / pathology

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(PMID = 16049726.001).

[ISSN] 1435-2443

[Journal-full-title] Langenbeck's archives of surgery

[ISO-abbreviation] Langenbecks Arch Surg

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Germany

   

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BACKGROUND: Adjuvant chemotherapy of oral uracil/ftorafur (UFT) plus leucovorin (LV) has been accepted as the standard of care in the treatment of patients with stage II and III carcinoma of the colon.

CONCLUSIONS: HRQOL in colorectal cancer patients with adjuvant chemotherapy with oral UFT plus LV deteriorated during this phase of treatment compared with those with surgery alone, despite the biased stage of tumor between the groups.

[MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / surgery. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colectomy. Colorectal Neoplasms / drug therapy. Colorectal Neoplasms / surgery. Quality of Life

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[Cites] Cancer. 2000 Mar 15;88(6):1294-303 [10717609.001]

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(PMID = 20191299.001).

[ISSN] 1437-7772

[Journal-full-title] International journal of clinical oncology

[ISO-abbreviation] Int. J. Clin. Oncol.

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] Japan

[Chemical-registry-number] 0 / Drug Combinations; 0 / UFT(R) drug; 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; Q573I9DVLP / Leucovorin

   

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Haematoxylin and Eosin stained slides were examined to determine the histological type, grade and stage of CRC.

RESULTS: Among the 100 cases, 59 were non mucinous adenocarcinomas, of which 4 were in Dukes' stage A, 51 were in Dukes' stage B and 4 were in Dukes' stage C.

In thirty cases of mucinous carcinomas, 18 were in Dukes' stage B and 12 were in Dukes' stage C, of these 2 were of grade I, 20 were of grade II and 8 were of grade III.

All the 11 signet ring cell carcinomas were of grade III and in Dukes' stage C.

CONCLUSION: Mucin secreting and signet-ring cell adenocarcinomas of colon and rectum are high grade tumours and presented at an advanced stage.

[MeSH-major] Adenocarcinoma / classification. Adenocarcinoma / pathology. Colorectal Neoplasms / classification. Colorectal Neoplasms / pathology. Neoplasm Staging

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(PMID = 21381550.001).

[ISSN] 0030-9982

[Journal-full-title] JPMA. The Journal of the Pakistan Medical Association

[ISO-abbreviation] J Pak Med Assoc

[Language] eng

[Publication-type] Evaluation Studies; Journal Article

[Publication-country] Pakistan

   

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A T3N0 preoperative tumor stage was found in 21 (75%) patients in the LI group and in 33 (85%) patients in the SI group (p = 0.36).

All tumors were histologically proven adenocarcinoma.

[MeSH-minor] Adenocarcinoma. Age Factors. Aged. Digestive System Surgical Procedures. Female. Humans. Male. Middle Aged. Radiotherapy, Adjuvant. Time Factors. Treatment Outcome

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[Cites] Int J Colorectal Dis. 2007 May;22(5):507-13 [17009009.001]

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(PMID = 19415307.001).

[ISSN] 1432-1262

[Journal-full-title] International journal of colorectal disease

[ISO-abbreviation] Int J Colorectal Dis

[Language] eng

[Publication-type] Journal Article

[Publication-country] Germany

   

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C-reactive protein, albumin and carcinoembryonic antigen are not predictive of cancer site, Duke's stage or influenced by patient age or gender.

[MeSH-major] Adenocarcinoma / pathology. Colonoscopy. Colorectal Neoplasms / pathology. Sigmoidoscopy

[MeSH-minor] Anemia / diagnosis. Anemia / etiology. Colon, Ascending / pathology. Constipation / etiology. Diarrhea / etiology. Humans. Risk Factors

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[CommentIn] Colorectal Dis. 2010 Aug;12(8):834-5 [20456465.001]

(PMID = 19207710.001).

[ISSN] 1463-1318

[Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

[ISO-abbreviation] Colorectal Dis

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

   

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LNgamma2 expression was seen in 57% of patients with biliary tract cancer, and was associated with depth of invasion, histologic type, and advanced stage.

The invasive front dominant type was associated with histologic type and advanced stage.

Active MMP7 detected by casein zymography was correlated with depth of invasion and advanced stage.

[MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Aged. Animals. Cell Line, Tumor. Female. Humans. Male. Middle Aged. RNA, Small Interfering / genetics. RNA, Small Interfering / metabolism

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(PMID = 19701966.001).

[ISSN] 2219-2840

[Journal-full-title] World journal of gastroenterology

[ISO-abbreviation] World J. Gastroenterol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] China

[Chemical-registry-number] 0 / Cell Adhesion Molecules; 0 / LAMC2 protein, human; 0 / Laminin; 0 / RNA, Small Interfering; 0 / kalinin; 170834-93-2 / laminin alpha 3; EC 3.4.24.23 / MMP7 protein, human; EC 3.4.24.23 / Matrix Metalloproteinase 7

[Other-IDs] NLM/ PMC2731248

   

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BACKGROUND: KAI1 COOH-terminal interacting tetraspanin (KITENIN) promotes tumor cell migration, invasion and metastasis in colon, bladder, head and neck cancer.

Expression of KITENIN was significantly associated with tumor size, Lauren classification, depth of invasion, lymph node metastasis, tumor stage and poor survival.

[MeSH-major] Adenocarcinoma / pathology. Biomarkers, Tumor / analysis. Carrier Proteins / metabolism. Membrane Proteins / metabolism. Stomach Neoplasms / pathology

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(PMID = 20944126.001).

[ISSN] 1791-7530

[Journal-full-title] Anticancer research

[ISO-abbreviation] Anticancer Res.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Greece

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carrier Proteins; 0 / Membrane Proteins; 0 / RNA, Small Interfering; 0 / Transcription Factor AP-1; 0 / VANGL1 protein, human

   

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[Title] Abnormal expression of Endoglin and its receptor complex (TGF-β1 and TGF-β receptor II) as early angiogenic switch indicator in premalignant lesions of the colon mucosa.

The simultaneous expression of Endoglin (CD105), transforming growth factor (TGF)-β1 and TGF-β receptor (R) II were quantified in surgical specimens comprising normal human colon, pre-malignant dysplastic tissue, in situ, and invasive colon cancer specimens, at mRNA and protein levels, respectively by real-time PCR and immunohistochemistry.

Serum concentrations of soluble Endoglin and TGF-β1 were evaluated. mRNA and CD105+-microvessel density (MVD) increased significantly in dysplastic colon and carcinoma versus normal tissues; values correlated respectively with dysplasia degree and Dukes' stages.

TGF-β1 RII was overexpressed in adenoma and carcinoma versus normal samples, but unrelated with dysplasia or Dukes' stage.

These findings suggest active angiogenesis occurs in many pre-malignant colon cases and supports more careful evaluation of different chemopreventive agents.

[MeSH-major] Adenocarcinoma / metabolism. Antigens, CD / biosynthesis. Colonic Neoplasms / metabolism. Precancerous Conditions / metabolism. Protein-Serine-Threonine Kinases / biosynthesis. Receptors, Cell Surface / biosynthesis. Receptors, Transforming Growth Factor beta / biosynthesis. Transforming Growth Factor beta1 / biosynthesis

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(PMID = 20878063.001).

[ISSN] 1791-2423

[Journal-full-title] International journal of oncology

[ISO-abbreviation] Int. J. Oncol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Greece

[Chemical-registry-number] 0 / Antigens, CD; 0 / ENG protein, human; 0 / Receptors, Cell Surface; 0 / Receptors, Transforming Growth Factor beta; 0 / Transforming Growth Factor beta1; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.30 / transforming growth factor-beta type II receptor

   

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METHODS: From 1995 to 2000, 108 patients with adenocarcinoma of the colon or rectum, underwent curative surgery and enrolled in this prospective study.

The proportion of patients with portal CEA > or =5 ng/ml was greater in patients with higher stage than in patients with lower stage.

[MeSH-major] Adenocarcinoma / diagnosis. Biomarkers, Tumor / blood. Carcinoembryonic Antigen / blood. Carcinoembryonic Antigen / genetics. Colonic Neoplasms / diagnosis. Rectal Neoplasms / diagnosis

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[Copyright] Copyright 2006 Wiley-Liss, Inc.

(PMID = 16788936.001).

[ISSN] 0022-4790

[Journal-full-title] Journal of surgical oncology

[ISO-abbreviation] J Surg Oncol

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen; 0 / RNA, Messenger

   

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[Title] Are 12 nodes needed to accurately stage T1 and T2 colon cancers?

Evaluation of 12 lymph nodes has been mandated to prevent colon cancer understaging.

Given that the probability of node metastases is largely associated with T-stage, are <12 nodes substandard for T1 and T2 lesions?

In SEER, 61,237 patients undergoing colon cancer resection were identified.

For each T-stage, 5-year survival rates were compared for node-negative cancers by using stepwise node cut-point comparisons (4 nodes, <4, etc.).

In conclusion, the number of nodes to stage T1 and T2 lesions may be <12.

[MeSH-major] Adenocarcinoma / pathology. Colon / pathology. Colonic Neoplasms / pathology. Lymphatic Metastasis / diagnosis. Neoplasm Staging / standards

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[CommentIn] Dig Dis Sci. 2009 Apr;54(4):914-5; author reply 916 [19003528.001]

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(PMID = 18612817.001).

[ISSN] 1573-2568

[Journal-full-title] Digestive diseases and sciences

[ISO-abbreviation] Dig. Dis. Sci.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

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[Title] P53 and heat shock protein 70 expressions in colorectal adenocarcinoma.

OBJECTIVE: To examine the localization and over expression of heat shock protein 70 (HSP70) and p53 in patients with colorectal cancer and compared it with control tissue (including normal colon tissue).

METHODS: This was a retrospective study of 60 patients with colorectal adenocarcinoma at the Jordan University of Science and Technology (JUST), Irbid, Jordan from 1997 to 2000.

Immuno-histochemistry showed that over expression of HSP70 had no statistically significant difference with any of the different prognostic factors assessed, mainly the grade and the stage.

Control tissue (normal colon) was negative, p53, cell-cycle-related oncogene product, was strongly over expressed in the nuclei of the cancer cells of the cancer tissue.

We found no significant difference in terms of size, patient age, lymph node state, and stage.

[MeSH-major] Adenocarcinoma / pathology. Biomarkers, Tumor / analysis. Colorectal Neoplasms / pathology. HSP70 Heat-Shock Proteins / metabolism. Tumor Suppressor Protein p53 / metabolism

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(PMID = 16228064.001).

[ISSN] 0379-5284

[Journal-full-title] Saudi medical journal

[ISO-abbreviation] Saudi Med J

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] Saudi Arabia

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / HSP70 Heat-Shock Proteins; 0 / Tumor Suppressor Protein p53

   

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[Title] Simultaneous laparoscopic descending colectomy and nephroureterectomy for descending colon carcinoma and left ureteral carcinoma: report of a case.

To our knowledge, there is no case report of the synchronous resection of colon and ureteral carcinomas by laparoscopy, because of the rareness of this combination and the technical difficulties involved.

We report a case of simultaneous descending colon and left ureteral carcinomas, both of which were judged to be relatively early stage carcinoma, which we resected successfully laparoscopically.

[MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Aged. Carcinoma, Papillary / pathology. Carcinoma, Papillary / surgery. Carcinoma, Transitional Cell / pathology. Carcinoma, Transitional Cell / surgery. Colonoscopy. Humans. Laparoscopy. Male. Urography

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[Cites] Ann Surg. 2007 Oct;246(4):655-62; discussion 662-4 [17893502.001]

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[Cites] Urology. 2001 Jan;57(1):133-7 [11164158.001]

(PMID = 19639445.001).

[ISSN] 1436-2813

[Journal-full-title] Surgery today

[ISO-abbreviation] Surg. Today

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Japan

   

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Cancers were staged according to the Dukes classification (Stage A in 41 percent, Stage B in 28 percent, and Stage C in 31 percent; median distance from the anal margin, 3 (range, 1-5) cm).

[MeSH-major] Adenocarcinoma / surgery. Adenoma, Villous / surgery. Anal Canal / surgery. Carcinoid Tumor / surgery. Colectomy / methods. Rectal Neoplasms / surgery

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(PMID = 16086223.001).

[ISSN] 0012-3706

[Journal-full-title] Diseases of the colon and rectum

[ISO-abbreviation] Dis. Colon Rectum

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil

   

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[Title] Prognostic significance of peritoneal washing cytology in Thai patients with gastric adenocarcinoma undergoing curative D2 gastrectomy.

BACKGROUND: The aim of the present study was to determine the prognostic significance of peritoneal washing cytology (PWC) among Thai patients with gastric adenocarcinoma.

METHODS: Medical charts of 97 patients with gastric adenocarcinoma who underwent curative D2 gastrectomy between October 1995 and September 2005 were reviewed.

Factors significantly associated with positive PWC included tumor location, macroscopic findings, histology, depth of tumor invasion, nodal involvement, TNM stage, and angiolymphatic invasion.

CONCLUSION: Gastric adenocarcinoma with positive PWC should be considered stage IV disease.

PWC should be included in the staging of gastric adenocarcinoma.

[MeSH-major] Adenocarcinoma / pathology. Peritoneal Neoplasms / pathology. Peritoneum / cytology. Stomach Neoplasms / pathology

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[Cites] J Am Coll Surg. 2006 Feb;202(2):231-6 [16427547.001]

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(PMID = 17334713.001).

[ISSN] 1436-3291

[Journal-full-title] Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association

[ISO-abbreviation] Gastric Cancer

[Language] eng

[Publication-type] Journal Article

[Publication-country] Japan

   

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[Title] Graft-versus-tumor effect after reduced-intensity allogeneic hematopoietic stem cell transplantation in a patient with advanced colon cancer.

A 27-year-old man with advanced colon cancer that was resistant to conventional chemoradiotherapies was treated with reduced-intensity allogeneic peripheral blood stem cell transplantation (PBSCT).

The antitumor effect observed in this patient was insufficient for the patient to achieve complete remission, because the disease was at an already widespread and treatment-resistant stage.

He finally died of hepatic failure due to extensive liver GVHD 65 months after the diagnosis of the advanced colon cancer and 29 months after the allogeneic PBSCT.

Prospective studies are necessary to achieve better clinical results in patients with advanced colon cancer.

[MeSH-major] Adenocarcinoma / therapy. Colonic Neoplasms / therapy. Graft vs Host Disease / etiology. Hematopoietic Stem Cell Transplantation

Genetic Alliance. consumer health - Transplantation.

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(PMID = 18463966.001).

[ISSN] 1341-9625

[Journal-full-title] International journal of clinical oncology

[ISO-abbreviation] Int. J. Clin. Oncol.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Japan

   

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[Title] Is there a difference in survival between right- versus left-sided colon cancers?

BACKGROUND: The incidence of right-sided colon cancers has been increasing in recent years.

In this study, we have compared the survival of right-and left-sided colon cancers in a longitudinal population-based database.

METHODS: A retrospective survival analysis was performed using the Surveillance, Epidemiology, and End Results Program (SEER) database between 1988 and 2003 on subjects who underwent surgical resection for the a primary diagnosis of pathologically confirmed invasive colon adenocarcinoma.

Cox proportional hazard regression analysis was used to assess long-term survival outcomes comparing right-sided (cecum to transverse colon, excluding appendix) versus left-sided (splenic flexure to sigmoid, excluding rectum) colon cancers.

RESULTS: A total of 77,978 subjects were identified with adenocarcinoma of the colon.

By Cox proportional hazard regression analysis, controlling for statistically significant confounders, including age, sex, race, marital status, tumor stage, tumor size, histologic grade, number of lymph nodes examined, and year of diagnosis, right-sided colon cancers were associated with a 5% increased mortality risk compared with left-sided colon cancers (hazard ratio, 1.04; 95% confidence interval, 1.02-1.07).

CONCLUSION: On the basis of analysis of information from the SEER database, we found that right-sided colon cancers have a worse prognosis than left-sided colon cancers.

The reason for this remains unclear but may be due to biological and/or environmental factors and may have particular bearing, given the rising incidence of right-sided colon cancers.

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(PMID = 18622647.001).

[ISSN] 1534-4681

[Journal-full-title] Annals of surgical oncology

[ISO-abbreviation] Ann. Surg. Oncol.

[Language] ENG

[Grant] United States / NIDDK NIH HHS / DK / DK007713-13; United States / NIDDK NIH HHS / DK / T32 DK007713; United States / NIDDK NIH HHS / DK / T32 DK007713-13; United States / NIDDK NIH HHS / DK / T32DK007713

[Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural

[Publication-country] United States

[Other-IDs] NLM/ NIHMS280426; NLM/ PMC3072702

   

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METHODS: From 1995 to 1998, patients with a non-fixed rectal adenocarcinoma (tumor stage T2) preserving the lower margin at 1-3 cm above the dentate line without distant metastasis was enrolled (period I).

CONCLUSION: As to ultra-low rectal cancer, intersphincteric resection could provide acceptable local control and cancer-related survival with no permanent stoma in early-staged tumor (tumor stage T2); moreover, preoperative concurrent chemoradiotherapy would make ISR feasible with surgical curative intent in more advanced tumors (tumor stages T3-4).

Genetic Alliance. consumer health - Rectal Cancer.

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(PMID = 16489683.001).

[ISSN] 1007-9327

[Journal-full-title] World journal of gastroenterology

[ISO-abbreviation] World J. Gastroenterol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] China

[Other-IDs] NLM/ PMC4066102