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[Title] [Analysis of clinicopathological, tumor cell proliferation and apoptosis parameters in adenocarcinoma of the gastric cardia].

[Transliterated title] Estudo clínico-patológico, da proliferação celular e da apoptose no adenocarcinoma gástrico da cárdia.

BACKGROUND/AIMS: In view of the increased incidence of carcinoma of the cardia over recent years, this work had the aim of studying the clinicopathological aspects, cell proliferative and tumor apoptotic indices of this neoplasm, their interrelations and possible influences on the prognosis.

MATERIAL AND METHODS: Forty cases of adenocarcinoma of the cardia were studied between 1988 and 2001, with a minimum clinical follow-up of 3 years.

CONCLUSIONS: Adenocarcinoma of the cardia predominated in male adults of mean age 61 years, and the predominant type was diffuse in more advanced stages.

Survival in cases of adenocarcinoma of the cardia is still low.

Both age and apoptosis were independent prognostic factors in cancer of the cardia.

[MeSH-major] Adenocarcinoma / pathology. Apoptosis. Cardia / pathology. Cell Proliferation. Stomach Neoplasms / pathology

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(PMID = 17160232.001).

[ISSN] 0004-2803

[Journal-full-title] Arquivos de gastroenterologia

[ISO-abbreviation] Arq Gastroenterol

[Language] por

[Publication-type] English Abstract; Journal Article

[Publication-country] Brazil

[Chemical-registry-number] 0 / Proliferating Cell Nuclear Antigen

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Gastric cardia adenocarcinoma in Taiwanese men: positive associations due to selection bias.

The factors associated with an increase in gastric cardia adenocarcinoma are poorly understood.

In conducting studies to establish the relationship between potential risk factors and gastric cardia adenocarcinoma, it is necessary to carefully consider the role of bias.

In a recently published study, the reported associations between H. pylori as well as post-meal physical exertion and gastric cardia adenocarcinoma may have been greatly influenced by selection bias.

[MeSH-major] Adenocarcinoma / etiology. Helicobacter Infections / complications. Helicobacter pylori / pathogenicity. Stomach Neoplasms / etiology

[MeSH-minor] Asian Continental Ancestry Group. Cardia. Case-Control Studies. Humans. Male. Reproducibility of Results. Risk Assessment. Risk Factors. Selection Bias. Taiwan / epidemiology

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[CommentOn] World J Gastroenterol. 2009 Nov 21;15(43):5472-80 [19916179.001]

(PMID = 20333802.001).

[ISSN] 2219-2840

[Journal-full-title] World journal of gastroenterology

[ISO-abbreviation] World J. Gastroenterol.

[Language] eng

[Publication-type] Comment; Letter

[Publication-country] China

[Other-IDs] NLM/ PMC2846267

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Aberrant methylation of thrombospondin-1 and its association with reduced expression in gastric cardia adenocarcinoma.

AIM: Investigate the promoter methylation of the Thrombospondin-1 (TSP1) gene in gastric cardia adenocarcinoma (GCA).

[MeSH-major] Adenocarcinoma / genetics. Promoter Regions, Genetic / genetics. Stomach Neoplasms / genetics. Thrombospondin 1 / genetics

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(PMID = 20300551.001).

[ISSN] 1110-7251

[Journal-full-title] Journal of biomedicine & biotechnology

[ISO-abbreviation] J. Biomed. Biotechnol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Thrombospondin 1

[Other-IDs] NLM/ PMC2838370

   

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[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Differences in the histological findings, phenotypic marker expressions and genetic alterations between adenocarcinoma of the gastric cardia and distal stomach.

Adenocarcinoma of the gastric cardia (C-Ca) is possibly a specific subtype of gastric carcinoma.

The purpose of this study was to clarify the differences in the clinicopathological characteristics between C-Ca and adenocarcinoma of the distal stomach (D-Ca), and also the differences in the expressions of gastric and intestinal phenotypic markers and genetic alterations between the two.

The phenotypic marker expressions examined were those of human gastric mucin (HGM), MUC6, MUC2 and CD10.

Oesophageal invasion by the tumour beyond the oesophago-gastric junction (OGJ) was found in 56.9% of cases with C-Ca; LVI in the area of oesophageal invasion was demonstrated in 61% of these cases.

[MeSH-major] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Biomarkers, Tumor / genetics. DNA, Neoplasm / genetics. Gene Expression Regulation, Neoplastic / genetics. Stomach Neoplasms / genetics. Stomach Neoplasms / pathology

[MeSH-minor] Aged. Cardia / pathology. DNA Mutational Analysis / methods. Disease Progression. Esophagus / pathology. Female. Humans. Male. Mutation. Neoplasm Invasiveness. Neoplasm Staging. Phenotype. Sensitivity and Specificity

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(PMID = 17262083.001).

[ISSN] 0007-0920

[Journal-full-title] British journal of cancer

[ISO-abbreviation] Br. J. Cancer

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm

[Other-IDs] NLM/ PMC2360051

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Histochemical studies on intestinal metaplasia adjacent to gastric cardia adenocarcinoma in subjects at high-incidence area in Henan, north China.

AIM: To characterize the histochemical type and pattern of intestinal metaplasia (IM) adjacent to gastric cardia adenocarcinoma (GCA) and distal gastric cancer (GC) in Linzhou, Henan Province, China.

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(PMID = 16094701.001).

[ISSN] 1007-9327

[Journal-full-title] World journal of gastroenterology

[ISO-abbreviation] World J. Gastroenterol.

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / R01 CA065871; United States / NCI NIH HHS / CA / CA65871

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

[Publication-country] United States

[Other-IDs] NLM/ PMC4615402

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Adenocarcinoma of gastric cardia in the elderly: surgical problems and prognostic factors.

AIM: To analyze retrospectively, our results about patients who underwent surgical treatment for adenocarcinoma of the cardia in relation to age, in order to evaluate surgical problems and prognostic factors.

METHODS: From January 1987 to March 2003, 140 patients with adenocarcinoma of the cardia underwent resection in the authors institution.

CONCLUSION: As the age of the general population increases, more elderly patients with gastric cardia cancer will be candidates for surgical resection.

Age alone should not preclude surgical treatment in elderly patients with gastric cardia cancer and a tumor resection can be carried out safely.

[MeSH-major] Adenocarcinoma / surgery. Aged. Cardia. Stomach Neoplasms / surgery

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(PMID = 16127740.001).

[ISSN] 1007-9327

[Journal-full-title] World journal of gastroenterology

[ISO-abbreviation] World J. Gastroenterol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] China

[Other-IDs] NLM/ PMC4320383

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Proteome analysis of human gastric cardia adenocarcinoma by laser capture microdissection.

BACKGROUND: The incidence of gastric cardiac adenocarcinoma (GCA) has been increasing in the past two decades in China, but the molecular changes relating to carcinogenesis have not been well characterised.

METHODS: In this study, we used a comparative proteomic approach to analyse the malignant and nonmalignant gastric cardia epithelial cells isolated by navigated laser capture microdissection (LCM) from paired surgical specimens of human GCA.

[MeSH-major] Adenocarcinoma / metabolism. Cardia / metabolism. Proteome / analysis. Stomach Neoplasms / metabolism

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(PMID = 17927838.001).

[ISSN] 1471-2407

[Journal-full-title] BMC cancer

[ISO-abbreviation] BMC Cancer

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Proteome

[Other-IDs] NLM/ PMC2151079

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Loss of heterozygosity at chromosome 8p21-p23 in adenocarcinoma of gastric cardia].

To investigate the involvement of the gene(s) in the carcinogenesis of adenocarcinoma of gastric cardia, loss of heterozygosity (LOH) for microsatellite markers at chromosome 8p21-p23 was examined.

Our data indicated that the tumor suppressor gene at chromosome 8p22 might play an important role in the development of adenocarcinoma of gastric cardia.

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(PMID = 16818423.001).

[ISSN] 0253-9772

[Journal-full-title] Yi chuan = Hereditas

[ISO-abbreviation] Yi Chuan

[Language] CHI

[Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] China

[Chemical-registry-number] 0 / DNA, Neoplasm

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Meta-analysis of antioxidant intake and the risk of esophageal and gastric cardia adenocarcinoma.

OBJECTIVE: The incidence of esophageal adenocarcinoma has been increasing rapidly among many countries.

We conducted a systematic review and statistical synthesis of studies that evaluated the associations between vitamin C, vitamin E, or beta-carotene/vitamin A and the risk of esophageal adenocarcinoma or the adjacent gastric cardia (gastroesophageal junction) adenocarcinoma.

(b) esophageal or cardia adenocarcinoma occurrence; and (c) a relative risk or odds ratio (OR) with confidence intervals (CI), or sufficient data to permit their calculation.

RESULTS: We identified 10 studies (1 cohort, 9 case-control; 1,057 esophageal and 644 cardia cases).

Summary estimates stratified by cancer site suggested that higher intakes of vitamin C, beta-carotene/vitamin A, and vitamin E were inversely associated with the risk of esophageal adenocarcinoma (vitamin C, OR 0.49, 95% CI 0.39-0.62, P(heterogeneity)= 0.10; beta-carotene, OR 0.46, 95% CI 0.36-0.59, P(heterogeneity)= 0.82; vitamin E intake, OR 0.80, 95% CI 0.63-1.03, P(heterogeneity)= 0.59).

Beta-carotene intake was also inversely associated with the risk of cardia adenocarcinoma (OR 0.57, 95% CI 0.46-0.72, P(heterogeneity)= 0.17).

CONCLUSIONS: Pooled results from observational studies suggest that antioxidant intake may be protective against esophageal adenocarcinoma; the data do not support a consistent association between antioxidant intake and the risk of cardia carcinoma.

[MeSH-major] Adenocarcinoma / etiology. Antioxidants. Cardia. Diet. Esophageal Neoplasms / etiology. Stomach Neoplasms / etiology

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(PMID = 17581269.001).

[ISSN] 0002-9270

[Journal-full-title] The American journal of gastroenterology

[ISO-abbreviation] Am. J. Gastroenterol.

[Language] eng

[Publication-type] Journal Article; Meta-Analysis

[Publication-country] United States

[Chemical-registry-number] 0 / Antioxidants

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Aberrant CpG island hypermethylation of RASSF1A in gastric cardia adenocarcinoma.

In this work, the promoter methylation status of the RASSF1A in 92 gastric cardia adenocarcinoma (GCA) and corresponding normal tissues were investigated using Methylation-specific PCR (MSP) approach, immunohistochemistry method and RT-PCR were used respectively to examine the protein expression and mRNA expression of RASSF1A in tumors and corresponding normal tissues.

[MeSH-major] Adenocarcinoma / genetics. Cardia / chemistry. CpG Islands. DNA Methylation. Gene Expression Regulation, Neoplastic. Gene Silencing. Stomach Neoplasms / genetics. Tumor Suppressor Proteins / genetics

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(PMID = 19160099.001).

[ISSN] 1532-4192

[Journal-full-title] Cancer investigation

[ISO-abbreviation] Cancer Invest.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / CCND1 protein, human; 0 / RASSF1 protein, human; 0 / RNA, Messenger; 0 / Tumor Suppressor Proteins; 136601-57-5 / Cyclin D1

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Prospective analysis of patients with adenocarcinoma of the gastric cardia and lymph node metastasis in the proximal field of the chest.

BACKGROUND: The extent to which adenocarcinoma of the cardia with lymph node metastasis in the upper mediastinum is amenable to cure by radical surgery is open to debate.

METHODS: Some 50 patients with adenocarcinoma of the gastric cardia and substantial invasion of the oesophagus (junctional type II), who underwent an extended transthoracic oesophagectomy as part of a prospective randomized trial between 1994 and 2000, were studied.

CONCLUSION: Lymph node metastasis in the proximal field of the chest is common and is an indicator of poor prognosis in patients with adenocarcinoma of the cardia.

[MeSH-major] Adenocarcinoma / surgery. Cardia. Mediastinal Neoplasms / secondary. Stomach Neoplasms / surgery

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(PMID = 16127682.001).

[ISSN] 0007-1323

[Journal-full-title] The British journal of surgery

[ISO-abbreviation] Br J Surg

[Language] eng

[Publication-type] Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

[Publication-country] England

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Dietary patterns and risk of squamous-cell carcinoma and adenocarcinoma of the esophagus and adenocarcinoma of the gastric cardia: a population-based case-control study in Sweden.

In total 185 patients with esophageal adenocarcinoma, 165 with esophageal squamous-cell carcinoma, 258 with gastric cardia adenocarcinoma, and 815 randomly selected population controls underwent face-to-face interviews.

A high score of Western diet was associated with increased risks of gastric cardia adenocarcinoma (high 3rd tertile vs. low 1st quartile, OR = 1.8, 95% CI = 1.1-2.9, P for trend = 0.04) and esophageal adenocarcinoma (high 3rd tertile vs. low 1st tertile, OR = 1.6, 95% CI = 0.9-3.1, P for trend = 0.13), whereas a dietary pattern characterized by high beer and liquor intake (alcohol drinker) significantly increased the risk of squamous-cell carcinoma of the esophagus (3rd tertile vs. low 1st tertile, OR = 3.5, 95% CI = 1.9-6.3, P for trend < 0.0001).

Our study confirms the important role of diet in the carcinogenesis of esophageal and cardia cancer.

[MeSH-major] Adenocarcinoma / epidemiology. Carcinoma, Squamous Cell / epidemiology. Esophageal Neoplasms / epidemiology. Food Habits. Stomach Neoplasms / epidemiology

[MeSH-minor] Aged. Alcohol Drinking. Cardia. Case-Control Studies. Diet Surveys. Factor Analysis, Statistical. Female. Humans. Male. Meat. Odds Ratio. Risk Assessment. Risk Factors. Sweden / epidemiology

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(PMID = 16898861.001).

[ISSN] 0163-5581

[Journal-full-title] Nutrition and cancer

[ISO-abbreviation] Nutr Cancer

[Language] eng

[Grant] United States / NCI NIH HHS / CA / R01 CA57947-03

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Neoadjuvant chemotherapy versus surgery alone for locally advanced adenocarcinoma of the stomach and cardia: Randomized EORTC phase III trial #40954.

: 4510 Background: Combined pre- and postoperative chemotherapy improves overall survival in operable gastric cancer, although postoperative treatment is not feasible in half of the patients.

METHODS: Patients with locally advanced adenocarcinoma of the stomach and cardia were randomized between primary surgery or two 48-day cycles of weekly folinic acid 500 mg/m²/2h, 5-FU 2,000 mg/m²/24h plus biweekly cisplatin 50 mg/m²/1h followed by surgery.

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(PMID = 27962708.001).

[ISSN] 1527-7755

[Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology

[ISO-abbreviation] J. Clin. Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Planned interim analysis of the intergroup FFCD-GERCOR-FNCLCC-AERO phase III study comparing two sequences of chemotherapy in locally advanced or metastatic gastric cancers.

: 4533 Background: There are several standard chemotherapies in locally advanced or metastatic gastric or cardia adenocarcinoma, including ECF.

METHODS: Patients (pts) with a gastric or cardiac adenocarcinoma, locally advanced or metastatic, not surgically curable, with a WHO PS ≤2 and evaluable or measurable lesions, were randomized (1:1) according to the following sequences: ECC (epirubicin 50 mg/m² D1+ cisplatin 60 mg/m² D1 + capecitabine 2000 mg/m² D2 to D15, every 3 weeks) in 1st line, then FOLFIRI (IRI 180 mg/m² D1, leucovorin 400 mg/m² D1, bolus 5FU 400 mg/m² D1 and continuous 5FU 2400 mg/m² in 46h, every 2 weeks) in 2^nd line (Arm A) vs the reverse sequence (Arm B) with a stratification for center, PS, adjuvant treatment, site, linitis and measurable disease.

Pts characteristics are: PS 1: 51%, med. age 60 years, gastric 67%, M+ 88%, resected primary tumor 27% and linitis 23%.

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(PMID = 27962993.001).

[ISSN] 1527-7755

[Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology

[ISO-abbreviation] J. Clin. Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Expression of p53 protein in Barrett's adenocarcinoma and adenocarcinoma of the gastric cardia and antrum.

BACKGROUND/AIM: Most studies of esophageal and gastric adenocarcinomas have shown a very high rate of p53 gene mutation and/or protein overexpression, but the influence of the tumour site upon the frequency of p53 protein expression has not been evaluated (gastroesophageal junction, Barret's esophagus, and antrum).

METHODS: The material comprised 66 surgical specimens; 10 were Barrett's carcinomas, 25 adenocarcinomas of the gastric cardia (type II adenocarcinoma of the esophagogastric junction - EGJ), and 31 adenocarcinomas of the antrum.

There was, however, a significant difference observed in the depth of tumour invasion between Barrett's adenocarcinoma and adenocarcinoma of the cardia compared with the adenocarcinoma of the antrum.

Namely, at the time of surgery, both Barrett's adenocarcinomas and adenocarcinomas of the cardia, were significantly more advanced comparing with the adenocarcinomas of the antrum.

Overexpression of p53 was found in 40% (4/10) of Barrett's adenocarcinomas, 72% (18/25) of adenocarcinoma of the cardia and 65% (20/31) of adenocarcinoma of the antrum.

Patients with more advanced Barrett's adenocarcinoma and in the cases of lymph node invasion revealed tendency for the greater p53 positivity compared with the early forms and lymph node-negative cases; however, this difference was not significant according to the statistical analysis.

With regard to adenocarcinoma of the cardia, higher rates of p53 positivity were recorded in poorly differentiated, more advanced cases with lymph node invasion.

On the contrary, in the patients with adenocarcinoma of the antrum, greater p53 positivity was revealed in early forms without lymph node involvement, but the observed difference was not statistically significant.

CONCLUSION: No significant differences in p53 protein expression in terms of sex, type (Lauren) of tumour, depth of invasion, lymph node involvement, or tumour differentiation were observed in any of the analyzed groups of tumours (Barrett's adenocarcinoma, adenocarcinoma of the cardia and adenocarcinoma of the antrum).

[MeSH-major] Adenocarcinoma / metabolism. Barrett Esophagus / complications. Cardia. Esophageal Neoplasms / metabolism. Pyloric Antrum. Stomach Neoplasms / metabolism. Tumor Suppressor Protein p53 / metabolism

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[CommentIn] Vojnosanit Pregl. 2006 Jan;63(1):87-8; author reply 88-9 [16471255.001]

(PMID = 16375215.001).

[ISSN] 0042-8450

[Journal-full-title] Vojnosanitetski pregled

[ISO-abbreviation] Vojnosanit Pregl

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Serbia and Montenegro

[Chemical-registry-number] 0 / Tumor Suppressor Protein p53

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Distinct recurrence pattern and outcome of adenocarcinoma of the gastric cardia in comparison with carcinoma of other regions of the stomach.

BACKGROUND: Carcinoma arising in the cardioesophageal junction is a distinct clinical entity compared with tumors located in other regions of the stomach.

The prognosis for adenocarcinoma of the upper stomach is considered to be relatively poorer than carcinomas of the more distal stomach.

We have therefore investigated patients with carcinoma of the gastric cardia in order to evaluate the underlying cause of this poor prognosis.

MATERIALS AND METHODS: Clinicopathologic features and postoperative prognosis of 101 patients with carcinoma of the cardia were evaluated and compared with findings on 1884 patients with tumors in other regions of the stomach.

RESULTS: Tumors of the cardia had a mean size of 6.8 cm, which was significantly larger than the mean size of 5.9 cm for tumors found in the middle- and lower third of the stomach.

The incidence of serosal invasion, lymph node metastasis, and lymphatic and blood vessel invasion was higher in association with adenocarcinoma of the cardia than with adenocarcinoma in remaining parts of the stomach.

In the analysis of patients who had undergone curative resection, the 5-year survival rates were 61.6, 79.1, and 82.6% in patients with carcinoma of the cardia, upper one-third, and remaining middle- and lower one-third of the stomach, respectively, and the differences were statistically significant.

Multivariate analysis indicated that adenocarcinoma of the gastric cardia is an independent prognostic factor.

With regard to the site of recurrence, both lymph node and hematogenous recurrence were observed more frequently in the cardia than in the remaining parts of the stomach.

CONCLUSIONS: Our data indicate that the prognosis of patients with adenocarcinoma of the gastric cardia is extremely poor.

[MeSH-major] Adenocarcinoma / pathology. Cardia. Gastric Fundus. Neoplasm Recurrence, Local / epidemiology. Stomach Neoplasms / pathology

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[Cites] J Am Coll Surg. 1995 May;180(5):577-82 [7749534.001]

[Cites] Surgery. 1992 Apr;111(4):386-93 [1557684.001]

[Cites] Surg Oncol. 1995;4(2):75-81 [7551262.001]

[Cites] Cancer. 1992 Aug 1;70(3):569-74 [1623472.001]

[Cites] Surgery. 1999 Feb;125(2):195-201 [10026754.001]

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(PMID = 16983479.001).

[ISSN] 0364-2313

[Journal-full-title] World journal of surgery

[ISO-abbreviation] World J Surg

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Association of ablation of Barrett's esophagus with high grade dysplasia and adenocarcinoma of the gastric cardia.

Three cases are reported in which the patient developed adenocarcinoma of the gastric cardia after thermal ablation of HGD.

Three cases are reported with long-segment BE and a nodule or mass in the endoscopic cardia post-thermal ablation.

Biopsies documented adenocarcinoma of the gastric cardia.

The development of adenocarcinoma of the cardia is unexpected.

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(PMID = 16866860.001).

[ISSN] 1120-8694

[Journal-full-title] Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

[ISO-abbreviation] Dis. Esophagus

[Language] ENG

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Trend analysis for clinical characteristics and prognosis of adenocarcinoma of cardia].

BACKGROUND AND OBJECTIVE: The incidence of adenocarcinoma of the cardia has recently increased.

This study compared the clinicopathology and prognosis of patients with gastric cardia adenocarcinoma in different periods between 1984 and 2003.

METHODS: A total of 589 patients with pathologically confirmed gastric cardia adenocarcinoma hospitalized in Sun Yat-sen University Cancer Center between 1984 and 2003 were divided into 5-year groups.

CONCLUSIONS: During the past 20 years, associated with the upward-trending incidence of gastric cardia adenocarcinoma, the admission rate at our hospital of patients with the tumor increased.

[MeSH-major] Adenocarcinoma. Cardia / pathology. Stomach Neoplasms

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(PMID = 20038318.001).

[ISSN] 1000-467X

[Journal-full-title] Chinese journal of cancer

[ISO-abbreviation] Chin J Cancer

[Language] chi

[Publication-type] English Abstract; Journal Article

[Publication-country] China

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Association of functional polymorphisms in MMPs genes with gastric cardia adenocarcinoma and esophageal squamous cell carcinoma in high incidence region of North China.

The aim of the present study was to investigate the association of single nucleotide polymorphisms (SNPs) in matrix metalloproteinase (MMPs) with the risk of gastric cardia adenocarcinoma (GCA) and esophageal squamous cell carcinoma (ESCC).

[MeSH-major] Esophageal Neoplasms / epidemiology. Esophageal Neoplasms / genetics. Genetic Predisposition to Disease. Matrix Metalloproteinases / genetics. Polymorphism, Single Nucleotide / genetics. Stomach Neoplasms / epidemiology. Stomach Neoplasms / genetics

[MeSH-minor] Adenocarcinoma / enzymology. Adenocarcinoma / epidemiology. Adenocarcinoma / genetics. Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / enzymology. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / genetics. Case-Control Studies. China / epidemiology. Female. Gene Frequency / genetics. Haplotypes / genetics. Humans. Incidence. Male. Middle Aged

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[Cites] Int J Epidemiol. 2000 Aug;29(4):645-54 [10922340.001]

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(PMID = 19562509.001).

[ISSN] 1573-4978

[Journal-full-title] Molecular biology reports

[ISO-abbreviation] Mol. Biol. Rep.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Netherlands

[Chemical-registry-number] EC 3.4.24.- / Matrix Metalloproteinases

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Correlation of hypermethylation of TSP1 gene with TGF-beta1 level and T cell immunity in gastric cardia adenocarcinoma].

This study was to investigate the promoter methylation of TSP1 and its correlation with TGF-beta1 level and T cell immunity in gastric cardia adenocarcinoma (GCA).

[MeSH-major] Adenocarcinoma. Cardia. Stomach Neoplasms. Thrombospondin 1 / metabolism. Transforming Growth Factor beta1 / blood

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(PMID = 19958625.001).

[Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer

[ISO-abbreviation] Ai Zheng

[Language] chi

[Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] China

[Chemical-registry-number] 0 / Antigens, CD3; 0 / Thrombospondin 1; 0 / Transforming Growth Factor beta1

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [The application of surface-enhanced laser desorption/ionization-time of flight-mass spectrometry in diagnosing dysplasia and chronic atrophic gastric-carditis in population with high risk of gastric-cardia adenocarcinoma].

OBJECTIVES: To evaluate the serum biomarkers for diagnosis of gastric cardia dysplasia (DYS) and chronic atrophic gastric-carditis (CAG) and to provide a novel screening method for high risk population of gastric-cardia adenocarcinoma (GCA).

A set of spectra derived from analysis of serum from 143 symptom-free subjects at high-risk area for GCA, including 63 cases with histologically normal gastric cardia epithelia, 57 of CAG and 23 of DYS, were analyzed by bioinformatics like decision tree classification algorithm.

CONCLUSIONS: The gastric cardia lesions of DYS and CAG could be identified by SELDI-TOF-MS technique specifically in symptom-free subjects at high incidence area for GCA.

[MeSH-major] Biomarkers, Tumor / blood. Cardia. Gastritis, Atrophic / diagnosis. Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods. Stomach Neoplasms / diagnosis

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(PMID = 16194406.001).

[ISSN] 0578-1426

[Journal-full-title] Zhonghua nei ke za zhi

[ISO-abbreviation] Zhonghua Nei Ke Za Zhi

[Language] chi

[Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] China

[Chemical-registry-number] 0 / Biomarkers, Tumor

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Trends in the incidence of adenocarcinoma of the oesophagus and cardia in the Netherlands 1989-2003.

Over the 15-year period 1989-2003, the incidence of oesophagus-cardia adenocarcinoma in the Netherlands rose annually by 2.6% for males and 1.2% for females.

This was the net outcome of annual increases in the incidence of adenocarcinoma of the oesophagus (ACO) of 7.2% for males and 3.5% for females and annual declines in the incidence of adenocarcinoma of the gastric cardia (AGC) of more than 1% for both genders.

[MeSH-major] Adenocarcinoma / epidemiology. Cardia. Esophageal Neoplasms / epidemiology. Stomach Neoplasms / epidemiology

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(PMID = 17505507.001).

[ISSN] 0007-0920

[Journal-full-title] British journal of cancer

[ISO-abbreviation] Br. J. Cancer

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Other-IDs] NLM/ PMC2359916

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Adenocarcinoma of the oesophagus and gastric cardia: male preponderance in association with obesity.

Recent evidence links obesity with the rising incidence of oesophageal adenocarcinoma.

In Ireland between 1995 and 2004 the incidence of oesophageal adenocarcinoma increased by 38%, and this coincided with a 67% increase in the prevalence of obesity.

In this study, a prospective case-control study was undertaken in 760 patients presenting to a tertiary centre between 1994 and 2004 diagnosed with cancer of the oesophagus, gastric cardia or stomach.

Based on pre-illness BMI, 82% of patients who developed adenocarcinoma of the oesophagus were either overweight or obese compared with 59% of the healthy control population (P<0.001).

A dose-dependent relationship existed between BMI and oesophageal adenocarcinoma in males.

Using common cut-off points for BMI, the OR of adenocarcinoma of the lower oesophagus was 11.3 times higher (95% CI: 3.5-36.4) for individuals with a BMI >30 kg/m2 versus individuals with a BMI <22 kg/m2 (P<0.001 for trend).

For adenocarcinoma of the gastric cardia, males in the top quartile of BMI had an OR of 3.5 (95% CI: 1.3-9.4) compared with the lowest quartile (P=0.03 for trend).

The odds ratio for adenocarcinoma of the oesophagus, the oesophago-gastric junction and gastric cardia rose significantly with increasing BMI.

[MeSH-major] Adenocarcinoma / etiology. Carcinoma, Squamous Cell / etiology. Cardia. Esophageal Neoplasms / etiology. Obesity / complications. Stomach Neoplasms / etiology

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(PMID = 16630714.001).

[ISSN] 0959-8049

[Journal-full-title] European journal of cancer (Oxford, England : 1990)

[ISO-abbreviation] Eur. J. Cancer

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Body mass, tobacco and alcohol and risk of esophageal, gastric cardia, and gastric non-cardia adenocarcinoma among men and women in a nested case-control study.

OBJECTIVES: To prospectively assess the influence of body mass index (BMI), tobacco, and alcohol on the occurrence of esophageal, gastric cardia, and non-cardia gastric adenocarcinoma, and to detect any sex differences that could explain the male predominance of these tumors.

RESULTS: During follow-up of 4,340,207 person-years, we identified 287 esophageal adenocarcinomas, 195 gastric cardia adenocarcinomas, 327 gastric non-cardia adenocarcinomas, and 10,000 controls.

A positive association was found between overweight (BMI > 25 kg/m(2)) and esophageal adenocarcinoma (OR 1.67, 95% CI 1.22--2.30), and gastric cardia adenocarcinoma (OR 1.46, 95% CI 0.98--2.18), but not non-cardia gastric adenocarcinoma.

The association between BMI and esophageal and gastric cardia adenocarcinoma were dose-dependent and seemingly independent of reflux.

CONCLUSIONS: Overweight increases risk of esophageal and gastric cardia adenocarcinoma, while tobacco smoking increases risk of esophageal, gastric cardia, and non-cardia gastric adenocarcinoma.

[MeSH-major] Adenocarcinoma / epidemiology. Adenocarcinoma / etiology. Alcohol Drinking / adverse effects. Body Mass Index. Cardia / pathology. Esophageal Neoplasms / epidemiology. Esophageal Neoplasms / etiology. Smoking / adverse effects. Stomach Neoplasms / epidemiology. Stomach Neoplasms / etiology

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(PMID = 15947880.001).

[ISSN] 0957-5243

[Journal-full-title] Cancer causes & control : CCC

[ISO-abbreviation] Cancer Causes Control

[Language] eng

[Publication-type] Journal Article

[Publication-country] Netherlands

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Subclassification of superficial cardia cancer in relation to the endoscopic esophagogastric junction.

BACKGROUND: The incidence of adenocarcinoma of the gastric cardia has been reported to be increasing, but the endoscopic characteristics of the mucosal background of the tumor remain unclear.

The purpose of the present study was to evaluate the relationship between the location of the adenocarcinoma according to the esophagogastric junction (EGJ) and mucosal characteristics.

METHODS: Patients with superficial adenocarcinoma of the gastric cardia diagnosed pathologically were enrolled and divided into the above-EGJ group and the below-EGJ group according to tumor location.

We retrospectively reviewed endoscopic findings with respect to the classification of reflux esophagitis, hiatus hernia, valvular appearance of the cardia and the pattern of atrophic gastritis.

The severity of hiatus hernia and the valvular appearance of the cardia of patients in the above-EGJ group were worse than in the patients in the below-EGJ group.

CONCLUSION: There were significant differences between cancers above or below the EGJ, so classification of adenocarcinoma of the gastric cardia according to location is recommended.

[MeSH-major] Adenocarcinoma / pathology. Cardia / pathology. Endoscopy, Gastrointestinal. Esophagogastric Junction. Gastric Mucosa / pathology. Stomach Neoplasms / pathology

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(PMID = 19120911.001).

[ISSN] 1440-1746

[Journal-full-title] Journal of gastroenterology and hepatology

[ISO-abbreviation] J. Gastroenterol. Hepatol.

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] Australia

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Pathologic risk factors of adenocarcinoma of the gastric cardia and gastroesophageal junction.

Available evidence supports the existence of two major pathways of neoplastic development in the gastroesophageal region: the Barrett pathway, related to gastroesophageal reflux disease, and the gastric pathway, related to Helicobacter pylori infection.

The existence of an independent junctional pathway is questionable, and gastroesophageal junction adenocarcinomas share features of esophageal and gastric adenocarcinomas.

[MeSH-major] Adenocarcinoma / pathology. Cardia. Esophagogastric Junction / pathology. Stomach Neoplasms / pathology

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(PMID = 17030268.001).

[ISSN] 1055-3207

[Journal-full-title] Surgical oncology clinics of North America

[ISO-abbreviation] Surg. Oncol. Clin. N. Am.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] United States

[Number-of-references] 120

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Body mass index, height and risk of adenocarcinoma of the oesophagus and gastric cardia: a prospective cohort study.

BACKGROUND: In the last decades, the incidence of oesophageal and gastric cardia adenocarcinoma has increased rapidly in the Western world.

We investigated the association between body mass index (BMI), height and risk of oesophageal and gastric cardia adenocarcinoma.

After 13.3 years of follow-up, excluding the first follow-up year, complete data from 4552 subcohort members, 133 oesophageal and 163 gastric cardia adenocarcinomas were available for case-cohort analyses.

RESULTS: The RRs (95% CI) of oesophageal adenocarcinoma were 1.40 (0.95 to 2.04) and 3.96 (2.27 to 6.88) for overweight (BMI 25.0-29.9 kg/m(2)) and obese subjects (BMI >or=30.0 kg/m(2)), respectively, compared to subjects with normal weight (BMI 20.0-24.9 kg/m(2)).

For gastric cardia adenocarcinoma, these RRs were 1.32 (0.94 to 1.85) and 2.73 (1.56 to 4.79).

Also change in BMI during adulthood was positively associated with the risk of oesophageal and gastric cardia adenocarcinoma (p trend 0.001 and 0.02, respectively), while no association was found with BMI in early adulthood (p trend 0.17 and 0.17, respectively).

CONCLUSIONS: These results confirm higher risks of oesophageal and gastric cardia adenocarcinoma with increasing BMI.

This implies that the increasing prevalence of obesity may be one of the explanations for the rising incidence of oesophageal and gastric cardia adenocarcinoma in the Western world.

[MeSH-major] Adenocarcinoma / etiology. Body Height / physiology. Cardia. Esophageal Neoplasms / etiology. Obesity / complications. Stomach Neoplasms / etiology

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[Cites] Br J Cancer. 2000 Jul;83(1):127-32 [10883680.001]

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[CommentIn] Gut. 2007 Nov;56(11):1493-4 [17938426.001]

(PMID = 17337464.001).

[ISSN] 1468-3288

[Journal-full-title] Gut

[ISO-abbreviation] Gut

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Other-IDs] NLM/ PMC2095659

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] A positive family history of esophageal/gastric cardia cancer with gastric cardia adenocarcinoma is associated with a younger age at onset and more likely with another synchronous esophageal/gastric cardia cancer in a Chinese high-risk area.

BACKGROUND: To find a genetic component in gastric cardia adenocarcinomas (GCA).

[MeSH-major] Adenocarcinoma / genetics. Asian Continental Ancestry Group. Cardia / pathology. Esophageal Neoplasms / genetics. Neoplasms, Multiple Primary / pathology. Stomach Neoplasms / genetics

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[Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.

(PMID = 20603233.001).

[ISSN] 1878-0849

[Journal-full-title] European journal of medical genetics

[ISO-abbreviation] Eur J Med Genet

[Language] eng

[Publication-type] Journal Article

[Publication-country] Netherlands

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Influence of a microscopic positive proximal margin in the treatment of gastric adenocarcinoma of the cardia.

AIM: To investigate the influence of a positive proximal margin in total gastrectomy patients with gastric adenocarcinoma of the cardia.

METHODS: Medical records of 191 patients with total gastrectomies for adenocarcinoma of the cardia between 1995 and 2000 were reviewed.

CONCLUSION: A positive margin is more of an indication of advanced disease in patients with gastric adenocarcinoma of the cardia rather than an independent prognostic factor for survival.

[MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Cardia / pathology. Gastrectomy / methods. Stomach Neoplasms / pathology. Stomach Neoplasms / surgery

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(PMID = 16804975.001).

[ISSN] 1007-9327

[Journal-full-title] World journal of gastroenterology

[ISO-abbreviation] World J. Gastroenterol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] China

[Other-IDs] NLM/ PMC4087938

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Clinicopathologic features of adenocarcinoma at the gastric cardia: is it different from distal cancer of the stomach?

BACKGROUND: Although the incidence of gastric cardia cancer is considerably less than more distal gastric cancer, the rate of occurrence is now increasing.

The objective of this study was to evaluate and compare the clinicopathologic findings of gastric cardia and more distal stomach adenocarcinoma.

STUDY DESIGN: Patients included in our study were those who underwent operations for gastric adenocarcinoma in our institute from 1981 to 2006, and who had undergone complete medical history, including history of daily alcohol consumption; smoking; body mass index; and pathologic examinations.

A total of 843 patients were included in our study, and were divided into cardia and noncardia cancer groups.

RESULTS: Among the 843 patients, 23 (2.8%) had gastric cardia cancer.

Mean size of cardia tumors was larger than noncardia tumors.

Although noncardia cancer was often detected at an early stage, gastric cardia cancer was most often diagnosed at an advanced stage.

Pathologically, cardia cancer was more invasive and had more lymphatic permeation and lymph node metastasis than noncardia cancer.

CONCLUSIONS: Gastric cardia cancer occurs at a low incidence of only 2.8% of resected gastric cancers.

Unlike cases of gastric cardia cancer in Western populations, body mass index is not associated with occurrence of gastric cardia cancer in our study.

Because gastric cardia cancer appears more aggressive than noncardia gastric cancer, early diagnosis and intervention are important.

[MeSH-major] Adenocarcinoma / pathology. Cardia / pathology. Stomach Neoplasms / pathology

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(PMID = 18222384.001).

[ISSN] 1879-1190

[Journal-full-title] Journal of the American College of Surgeons

[ISO-abbreviation] J. Am. Coll. Surg.

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Impact of splenectomy in patients with gastric adenocarcinoma of the cardia.

Previous reports have suggested that splenectomy treatment of gastric carcinoma of the cardia results in poor patient outcome, but the reason for this is unclear.

This study aimed to clarify the impact of splenectomy for gastric carcinoma patients.

A total of 118 patients with gastric carcinoma of the cardia were enrolled in this study.

Splenectomy should be limited in those patients with gastric cardia tumors invading the spleen or with metastatic bulky lymph nodes extending to the spleen.

[MeSH-major] Adenocarcinoma / surgery. Cardia. Splenectomy. Stomach Neoplasms / surgery

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[Cites] N Engl J Med. 1999 Mar 25;340(12):908-14 [10089184.001]

[Cites] J Clin Oncol. 2004 Jul 15;22(14):2767-73 [15199090.001]

[Cites] Surgery. 1996 Jul;120(1):40-4 [8693421.001]

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(PMID = 17514409.001).

[ISSN] 1091-255X

[Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

[ISO-abbreviation] J. Gastrointest. Surg.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Incidence of carcinoma of the oesophagus and gastric cardia. Changes over time and geographical differences.

BACKGROUND: The incidence of adenocarcinoma of the oesophagus is rising in many western countries including Sweden.

METHODS: We have studied the latest data concerning this as well as trends in the incidence of squamous cell carcinoma and adenocarcinoma of gastric cardia.

RESULTS: The results show an increasing incidence of adenocarcinoma in both oesophagus and gastric cardia.

Adenocarcinoma is now the most common histological type of cancer in the oesophageal/cardia region in Sweden.

Results also suggest a possible drift in location of adenocarcinoma from gastric cardia towards oesophagus.

[MeSH-major] Adenocarcinoma / epidemiology. Carcinoma, Squamous Cell / epidemiology. Cardia. Esophageal Neoplasms / epidemiology. Stomach Neoplasms / epidemiology

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(PMID = 17851842.001).

[ISSN] 0284-186X

[Journal-full-title] Acta oncologica (Stockholm, Sweden)

[ISO-abbreviation] Acta Oncol

[Language] eng

[Publication-type] Journal Article

[Publication-country] Norway

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Occupational exposures and risk of esophageal and gastric cardia cancers among male Swedish construction workers.

OBJECTIVE: The rising incidence and the strong male predominance among patients with esophageal and gastric cardia adenocarcinoma remain unexplained.

RESULTS: We found positive associations between high exposure to asbestos (IRR 4.5 [95% CI 1.4-14.3]) and cement dust (IRR 3.8 [95% CI 1.5-9.6]) and risk of esophageal adenocarcinoma.

Associations were seen between high exposure to asphalt fumes (IRR 2.3 [95% CI 1.0-5.3]) and wood dust (IRR 4.8 [95% CI 1.2-19.4]) and risk of cardia adenocarcinoma.

CONCLUSIONS: Exposure to asbestos and cement dust may be risk factors for esophageal adenocarcinoma, and exposure to asphalt fumes and wood dust may increase the risk of cardia adenocarcinoma.

[MeSH-major] Adenocarcinoma / etiology. Cardia / pathology. Construction Materials. Esophageal Neoplasms / etiology. Occupational Exposure / adverse effects. Stomach Neoplasms / etiology

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(PMID = 16049815.001).

[ISSN] 0957-5243

[Journal-full-title] Cancer causes & control : CCC

[ISO-abbreviation] Cancer Causes Control

[Language] eng

[Publication-type] Journal Article

[Publication-country] Netherlands

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Trends in incidence of esophageal and gastric cardia cancer in high-risk areas in China.

Incidence rates have risen for gastric cardia adenocarcinoma, whereas rates have remained stable for esophageal squamous cell carcinoma in many western countries.

The aim of this study was to describe and analyze trends in incidence rates for esophageal cancer and gastric cardia cancer in Cixian county, which is one of the high-risk areas for esophageal cancer in China as well as in the world.

For gastric cardia cancer, there were 1654 cases from 1988 to 2003.

A statistically significant increasing trend of gastric cardia cancer was observed during the study period.

Cixian county is a geographical region with a very high incidence of esophageal cancer and cardia cancer.

The trend in the incidence rates of esophageal cancer had decreased slightly; on the other hand, gastric cardia cancer showed a significantly increased trend in the last 16 years.

[MeSH-major] Cardia. Esophageal Neoplasms / epidemiology. Stomach Neoplasms / epidemiology

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(PMID = 18287862.001).

[ISSN] 1473-5709

[Journal-full-title] European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)

[ISO-abbreviation] Eur. J. Cancer Prev.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Increasing incidence of adenocarcinoma of the gastroesophageal junction and distal stomach in Canada -- an epidemiological study from 1964-2002.

BACKGROUND: The increasing incidence of esophageal and proximal gastric (cardia) adenocarcinoma and the decreasing incidence of distal gastric (antropyloric) adenocarcinoma has been documented in several populations.

Number of cases and rates per 100,000 age-adjusted to the 1996 Canadian standard, were obtained for all esophageal and gastric carcinoma cases reported between 1964 and 2002.

RESULTS: The incidence of adenocarcinoma of the distal esophagus increased in men and women (average annual increase of 9.5% in men; 4.3% in women).

The incidence of adenocarcinoma of the cardia increased in men and women (average annual increase of 7.3% in men; 5.8% in women).

The incidence of antropyloric adenocarcinoma increased in men and women (average annual increase of 4.4% in men; 5.3% in women).

CONCLUSIONS: There has been a significant increase in the incidence of adenocarcinoma around the gastroesophageal junction in men over the 39-year study period.

The increase in incidence of distal gastric adenocarcinoma is unexpected and may relate to a reclassification phenomenon, immigration trends in Ontario and a rising incidence of diffuse/signet ring cell adenocarcinoma.

[MeSH-major] Adenocarcinoma / epidemiology. Cardia. Esophageal Neoplasms / epidemiology. Esophagogastric Junction. Stomach Neoplasms / epidemiology

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(PMID = 16609756.001).

[ISSN] 0835-7900

[Journal-full-title] Canadian journal of gastroenterology = Journal canadien de gastroenterologie

[ISO-abbreviation] Can. J. Gastroenterol.

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] Canada

[Other-IDs] NLM/ PMC2659904

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Human papillomavirus DNA and P16(INK4A) expression in concurrent esophageal and gastric cardia cancers.

AIM: To investigate the relationship between human papillomavirus (HPV) infection and concurrent esophagus and gastric cardia cancer from the same patient (CC) and examine the significance of P16(INK4A) protein expression.

RESULTS: Among the CC specimens, HPV16-DNA was found in eight cases of esophageal squamous cell carcinoma (ESCC) and five cases of gastric cardia adenocarcinoma (GCA), respectively (47% vs 29%), and two of both ESCC and GCA.

P16(INK4A) may be a screening index in the HPV-associated carcinoma of gastric cardia.

[MeSH-major] Cardia / pathology. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. DNA, Viral / genetics. Esophageal Neoplasms / virology. Human papillomavirus 16 / genetics. Stomach Neoplasms / virology

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(PMID = 21155014.001).

[ISSN] 2219-2840

[Journal-full-title] World journal of gastroenterology

[ISO-abbreviation] World J. Gastroenterol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] China

[Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Viral

[Other-IDs] NLM/ PMC3001984

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] The gastric cardia is not a target for human papillomavirus-induced carcinogenesis.

BACKGROUND: Thousands of people in central Asia die every year from gastric cardia adenocarcinoma (GCA).

GCA arises in the transformation zone between the esophagus and the stomach, similar to cervical and oropharyngeal carcinoma, which arise in areas with transformation zone characteristics.

The analogous biology of the gastric cardia to the cervix and oropharynx, where human papillomavirus (HPV) is known to cause cancer, raises the possibility that GCA could be a HPV-associated cancer.

CONCLUSIONS: These results suggest that HPV does not contribute to gastric cardia carcinogenesis in north central China.

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[Cites] Sex Transm Infect. 1999 Oct;75(5):317-9 [10616355.001]

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(PMID = 20332262.001).

[ISSN] 1538-7755

[Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

[ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.

[Language] ENG

[Grant] United States / CCR NIH HHS / RC / N01RC47702; United States / Intramural NIH HHS / / Z99 CA999999; United States / CCR NIH HHS / RC / N01-RC-47702

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / DNA, Viral

[Other-IDs] NLM/ NIHMS179295; NLM/ PMC2852466

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Esophageal and gastric cardia cancers on 4238 Chinese patients residing in municipal and rural regions: a histopathological comparison during 24-year period.

BACKGROUND: Nutrition deficiencies or poverty traditionally have been recognized to be related with increased risk for esophageal cancer (EC) in rural regions at junction of Henan, Hebei, and Shanxi provinces in northern China--the highest incidence area for esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinoma (GCA).

However, the histopathological types, staging pattern, and occurrence of ESCC and GCA, especially for esophageal adenocarcinoma (EAC), which have been rarely examined in the Chinese population during the past decades in these areas have not been well characterized to date.

The present results demonstrate the difference in municipal and rural regions of ESCC, ECA, and GCA in histopathological types, and suggest that there may be different etiological factors involved in esophageal and gastric cardia carcinogenesis in these different areas.

[MeSH-major] Cardia / pathology. Esophageal Neoplasms / pathology. Stomach Neoplasms / pathology

[MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Adult. Aged. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / pathology. Chi-Square Distribution. China / epidemiology. Female. Humans. Incidence. Male. Middle Aged. Neoplasm Staging. Risk Factors. Rural Population. Urban Population

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[Cites] Hepatogastroenterology. 2001 Sep-Oct;48(41):1231-7 [11677937.001]

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(PMID = 18566857.001).

[ISSN] 0364-2313

[Journal-full-title] World journal of surgery

[ISO-abbreviation] World J Surg

[Language] eng

[Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Association of methylenetetrahydrofolate reductase and thymidylate synthase promoter polymorphisms with genetic susceptibility to esophageal and cardia cancer in a Chinese high-risk population.

To investigate the association between these polymorphisms and the risk of esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinoma (GCA), we conducted a case-control study in the Anyang area where the incidence of ESCC is highest in northern China.

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(PMID = 16045580.001).

[ISSN] 1120-8694

[Journal-full-title] Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

[ISO-abbreviation] Dis. Esophagus

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / CA 65871

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

[Publication-country] United States

[Chemical-registry-number] EC 1.5.1.20 / Methylenetetrahydrofolate Reductase (NADPH2); EC 2.1.1.45 / Thymidylate Synthase

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Polymorphisms in promoter region of FAS and FASL gene and risk of cardia gastric adenocarcinoma.

This study was designed to investigate the correlation of FAS-1377 G/A, -670 A/G and FASL-844 T/C polymorphisms with susceptibility to gastric cardiac adenocarcinoma in a population of a high-incidence region of Hebei Province.

METHODS: FAS-1377 G/A, -670 A/G and FASL-844 T/C polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism analysis in 262 gastric cardiac carcinoma (GCA) patients and 524 healthy controls.

[MeSH-major] Adenocarcinoma / genetics. Antigens, CD95 / genetics. Biomarkers, Tumor / genetics. Cardia. Fas Ligand Protein / genetics. Polymorphism, Single Nucleotide. Stomach Neoplasms / genetics

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(PMID = 20074157.001).

[ISSN] 1440-1746

[Journal-full-title] Journal of gastroenterology and hepatology

[ISO-abbreviation] J. Gastroenterol. Hepatol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Australia

[Chemical-registry-number] 0 / Antigens, CD95; 0 / Biomarkers, Tumor; 0 / Fas Ligand Protein

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Adenosine diphosphate ribosyl transferase and x-ray repair cross-complementing 1 polymorphisms in gastric cardia cancer.

This study examined the effects of ADPRT Val762Ala and XRCC1 Arg399Gln polymorphisms on ADPRT-XRCC1 interaction in vitro in cells and their contributions to gastric cardia adenocarcinoma (GCA) risk.

[MeSH-major] ADP Ribose Transferases / genetics. Cardia / pathology. DNA, Neoplasm / genetics. DNA-Binding Proteins / genetics. Polymorphism, Genetic. Stomach Neoplasms / metabolism

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(PMID = 16890595.001).

[ISSN] 0016-5085

[Journal-full-title] Gastroenterology

[ISO-abbreviation] Gastroenterology

[Language] eng

[Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / DNA, Neoplasm; 0 / DNA-Binding Proteins; 0 / X-ray repair cross complementing protein 1; EC 2.4.2.- / ADP Ribose Transferases

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Cancer in esophagus and cardia--incidence trends in Denmark].

[Transliterated title] Kraeft i øsofagus og cardia--incidensudvikling i Danmark.

INTRODUCTION: The incidence of adenocarcinoma in esophagus and cardia has been reported as increasing in a number of countries over recent decades.

The study evaluates the incidence trends for esophagus- and stomach cancer in the period 1943-2003 with focus on changes since 1978.

The corresponding incidence rate for stomach cancer decreased over the entire study period from 21.9 per 100,000 in 1943-1947 to 9.7 per 100,000 in 1998-2003.

During the period 1978-2003 we observed a marked decrease in the incidence of adenocarcinoma in the distal stomach, whereas the incidence of adenocarcinoma in the cardia was constant in this period.

CONCLUSION: The incidence of esophageal adenocarcinoma has increased during the past 25 years in Denmark, whereas the incidence of adenocarcinoma in the cardia has remained constant.

[MeSH-major] Adenocarcinoma / epidemiology. Carcinoma, Squamous Cell / epidemiology. Cardia. Esophageal Neoplasms / epidemiology. Stomach Neoplasms / epidemiology

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(PMID = 18462626.001).

[ISSN] 1603-6824

[Journal-full-title] Ugeskrift for laeger

[ISO-abbreviation] Ugeskr. Laeg.

[Language] dan

[Publication-type] English Abstract; Journal Article

[Publication-country] Denmark

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] A prospective study of BMI and risk of oesophageal and gastric adenocarcinoma.

The incidence of oesophageal adenocarcinoma (EADC) is rapidly increasing in Western countries and obesity is thought to be a major risk factor.

We examined the association between BMI and EADC, gastric cardia adenocarcinoma and gastric non-cardia adenocarcinoma in a cohort of approximately 500,000 people in the United States (US).

We found that compared to people with a BMI of 18.5-25kg/m2, a BMI > or = 35 was associated with significantly increased risk of EADC, HR (95% CI)=2.27 (1.44-3.59) and gastric cardia adenocarcinoma 2.46 (1.60-3.80), but not gastric non-cardia adenocarcinoma 0.84 (0.50-1.42).

[MeSH-major] Adenocarcinoma / etiology. Attitude to Health. Body Mass Index. Cardia. Esophageal Neoplasms / etiology. Stomach Neoplasms / etiology

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[Cites] Cancer Causes Control. 2005 Apr;16(3):285-94 [15947880.001]

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(PMID = 18221867.001).

[ISSN] 0959-8049

[Journal-full-title] European journal of cancer (Oxford, England : 1990)

[ISO-abbreviation] Eur. J. Cancer

[Language] eng

[Grant] United States / Intramural NIH HHS / / Z99 CA999999

[Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Intramural

[Publication-country] England

[Other-IDs] NLM/ NIHMS42480; NLM/ PMC2350215

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Stent insertion as palliation of cancer in the esophagus and cardia].

[Transliterated title] Palliasjon med stent ved kreft i oesophagus og cardia.

BACKGROUND: The insertion of self-expanding metal stents (SEMS) for palliation of dysphagia in patients with malignant stenosis of the esophagus and cardia, is a well-established procedure.

CONCLUSION: Insertion of SEMS in patients with inoperable carcinoma in esophagus and cardia should be regarded as a safe procedure.

[MeSH-major] Cardia. Esophageal Neoplasms / therapy. Palliative Care / methods. Stents. Stomach Neoplasms / therapy

[MeSH-minor] Adenocarcinoma / complications. Adenocarcinoma / pathology. Adenocarcinoma / therapy. Adult. Aged. Carcinoma, Squamous Cell / complications. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / therapy. Deglutition Disorders / etiology. Deglutition Disorders / therapy. Esophageal Stenosis / etiology. Esophageal Stenosis / therapy. Esophagoscopy. Female. Humans. Male. Metals. Middle Aged. Prosthesis Implantation / adverse effects. Retrospective Studies. Survival Rate

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(PMID = 16770371.001).

[ISSN] 0807-7096

[Journal-full-title] Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række

[ISO-abbreviation] Tidsskr. Nor. Laegeforen.

[Language] nor

[Publication-type] English Abstract; Journal Article

[Publication-country] Norway

[Chemical-registry-number] 0 / Metals

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Postoperative imaging of the cardia and stomach].

[Transliterated title] Imagerie post-opératoire du cardia et de l'estomac.

In addition to treatment of complications from peptic ulcer disease, gastroesophageal reflux and gastric cancer, bariatric surgical procedures have increased over the recent years.

Complications after gastric surgery are imaged with upper gastrointestinal contrast studies and CT.

[MeSH-major] Adenocarcinoma / radiography. Adenocarcinoma / surgery. Cardia / surgery. Fundoplication. Gastrectomy. Gastroesophageal Reflux / surgery. Gastroplasty. Postoperative Complications / radiography. Stomach / surgery. Stomach Neoplasms / radiography. Stomach Neoplasms / surgery. Tomography, X-Ray Computed / methods

[MeSH-minor] Aged. Anastomosis, Surgical / adverse effects. Contrast Media. Gastric Bypass. Gastric Fistula / etiology. Gastroenterostomy. Humans. Lymph Node Excision. Male. Pancreas / surgery. Spleen / surgery

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(PMID = 19752832.001).

[ISSN] 0221-0363

[Journal-full-title] Journal de radiologie

[ISO-abbreviation] J Radiol

[Language] fre

[Publication-type] Case Reports; English Abstract; Journal Article; Review

[Publication-country] France

[Chemical-registry-number] 0 / Contrast Media

[Number-of-references] 30

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Self-reported goiter is associated with a significantly increased risk of gastric noncardia adenocarcinoma in a large population-based Chinese cohort.

Iodine is concentrated by the gastric mucosa, where it may act as an antioxidant.

Therefore, iodine deficiency, and its sequelae goiter, may be associated with an increased risk of gastric cancer.

Using multivariate adjusted Cox models, we found goiter associated with a significantly increased risk of gastric noncardia adenocarcinoma, HR (95% CI) 2.04 (1.01, 4.11) and nonsignificantly with gastric cardia adenocarcinoma, HR (95% CI) 1.45 (0.91, 2.30).

Our findings are consistent with the hypothesis that iodine deficiency is associated with an increased risk of gastric cancer.

[MeSH-major] Adenocarcinoma / epidemiology. Cardia. Goiter / epidemiology. Stomach Neoplasms / epidemiology

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(PMID = 16642482.001).

[ISSN] 0020-7136

[Journal-full-title] International journal of cancer

[ISO-abbreviation] Int. J. Cancer

[Language] eng

[Grant] United States / Intramural NIH HHS / /

[Publication-type] Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Intramural

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] What is the role of cytokeratins in Barrett/cardia differentiation?

The importance of distinguishing between Barrett metaplasia and intestinal metaplasia of the gastric cardia is now accepted, and the management of each entity is quite different.

Patients with Barrett metaplasia are enrolled in surveillance programs, consisting of periodic endoscopy and biopsy, because of the known risk of developing adenocarcinoma of the esophagus.

Patients with intestinal metaplasia of the gastric cardia, however, are not currently enrolled in such programs, because this condition carries a low risk of developing adenocarcinoma of the gastric cardia.

However, because it may be associated with premalignant lesions elsewhere in the gastric mucosa, we propose that intestinal metaplasia of the gastric cardia may have the same clinical implication as Barrett metaplasia.

[MeSH-major] Barrett Esophagus / etiology. Cardia / pathology. Keratins / physiology. Metaplasia / etiology. Stomach Diseases / etiology

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(PMID = 15679416.001).

[ISSN] 1543-2165

[Journal-full-title] Archives of pathology & laboratory medicine

[ISO-abbreviation] Arch. Pathol. Lab. Med.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers; 68238-35-7 / Keratins

[Number-of-references] 16

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Treatment and survival in a population-based sample of patients diagnosed with gastroesophageal adenocarcinoma.

METHODS: The US National Cancer Institutes' Patterns of Care study was used to examine therapies and survival of patients diagnosed in 2001 with histologically-confirmed gastroesophageal adenocarcinoma (n = 1356).

RESULTS: Approximately 62% of patients had stomach adenocarcinoma (SAC), while 22% had gastric-cardia adenocarcinoma (GCA), and 16% lower esophageal adenocarcinoma (EAC).

Stage IV/unstaged esophageal cancer patients were most likely and stage I-III stomach cancer patients least likely to receive chemotherapy as all or part of their therapy; gastric-cardia patients received chemotherapy at a rate between these two.

Among esophageal and stomach cancer patients, receipt of chemotherapy was associated with lower mortality; but no association was found among gastric-cardia patients.

Findings suggest that physicians treat lower esophageal and SAC as two distinct entities, while gastric-cardia patients receive a mix of the treatment strategies employed for the two other sites.

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[Cites] Eur J Cancer. 2005 May;41(7):1051-7 [15862755.001]

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(PMID = 18506920.001).

[ISSN] 1007-9327

[Journal-full-title] World journal of gastroenterology

[ISO-abbreviation] World J. Gastroenterol.

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / N01PC35143; United States / NCI NIH HHS / CA / N01PC35138; United States / NCI NIH HHS / CA / N01PC35141; United States / NCI NIH HHS / PC / N02 PC015105; United States / NCI NIH HHS / CA / N01PC35137; United States / NCI NIH HHS / CA / N01PC35133; United States / NCI NIH HHS / CA / N01PC35142; United States / NCI NIH HHS / CA / N01PC35135; United States / NCI NIH HHS / CA / N01PC35145; United States / NCI NIH HHS / CA / N01PC35136; United States / NCI NIH HHS / CA / N01PC35139

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Other-IDs] NLM/ PMC2712847

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Fiber intake and risk of adenocarcinomas of the esophagus and stomach.

BACKGROUND: Since the 1970s, incidence rates for esophageal and gastric cardia adenocarcinomas have risen substantially for reasons that are not well understood.

METHODS: This analysis on dietary factors included 206 esophageal adenocarcinoma, 257 gastric cardia, 366 distal gastric adenocarcinoma patients and, 1,308 control subjects from a population-based, case-control study conducted in Los Angeles County.

RESULTS: Intake of fiber had a significant impact on risk of esophageal and gastric cardia adenocarcinoma after adjustment for age, gender, race, birthplace, education, cigarette smoking, body size, history of reflux, and vitamin use.

Compared to subjects in the lowest quartile of fiber intake, subjects in the highest quartile of intake showed odd ratios of 0.44 (95% CI = 0.26-0.76) for esophageal adenocarcinoma (P trend = 0.004) and 0.58 (95% CI = 0.38-0.88) for gastric cardia adenocarcinoma (P trend = 0.016); these inverse associations remained after further adjustment for intake of fat.

For distal gastric cancer, a significant inverse association with fiber was observed only after adjustment for fat intake.

CONCLUSIONS: High intake of fiber was associated with significant reduced risks of esophageal and gastric cardia adenocarcinoma even after adjustment for dietary fat, H. pylori infection and other covariates.

[MeSH-major] Adenocarcinoma / etiology. Dietary Fiber / pharmacology. Eating / physiology. Esophageal Neoplasms / etiology. Stomach Neoplasms / etiology

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(PMID = 17562192.001).

[ISSN] 0957-5243

[Journal-full-title] Cancer causes & control : CCC

[ISO-abbreviation] Cancer Causes Control

[Language] eng

[Grant] United States / NIEHS NIH HHS / ES / 5P30 ES07048; United States / NCI NIH HHS / CA / CA59636; United States / NCI NIH HHS / CN / N01CN25403

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] Netherlands

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] A preliminary study on the postoperative survival of patients given aspirin after resection for squamous cell carcinoma of the esophagus or adenocarcinoma of the cardia.

BACKGROUND: We examined the effect of aspirin on survival following resection for squamous cell carcinoma (SCC) of the esophagus or adenocarcinoma of the gastric cardia.

There was a significant improvement in survival for patients with adenocarcinoma of the cardia on aspirin compared with the two control groups combined (P = 0.029).

However, there was no significant difference between the survival curves for T2N0M0 adenocarcinoma patients on aspirin (21) and the two control groups combined (65) (P = 0.29).

[MeSH-major] Adenocarcinoma / drug therapy. Aspirin / administration & dosage. Carcinoma, Squamous Cell / drug therapy. Cyclooxygenase 2 Inhibitors / administration & dosage. Esophageal Neoplasms / drug therapy. Stomach Neoplasms / drug therapy

[MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Cardia. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Combined Modality Therapy. Esophagectomy. Etoposide / administration & dosage. Female. Fluorouracil / administration & dosage. Gastrectomy. Humans. Male. Middle Aged. Radiotherapy, Adjuvant. Survival Analysis

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Hazardous Substances Data Bank. CIS-DIAMINEDICHLOROPLATINUM .

Hazardous Substances Data Bank. ETOPOSIDE .

Hazardous Substances Data Bank. ACETYLSALICYLIC ACID .

Hazardous Substances Data Bank. FLUOROURACIL .

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(PMID = 19241108.001).

[ISSN] 1534-4681

[Journal-full-title] Annals of surgical oncology

[ISO-abbreviation] Ann. Surg. Oncol.

[Language] eng

[Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Cyclooxygenase 2 Inhibitors; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; R16CO5Y76E / Aspirin; U3P01618RT / Fluorouracil

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Gastric acid suppression and risk of oesophageal and gastric adenocarcinoma: a nested case control study in the UK.

BACKGROUND: Gastric acid suppressing drugs (that is, histamine(2) receptor antagonists and proton pump inhibitors) could affect the risk of oesophageal or gastric adenocarcinoma but few studies are available.

AIMS: To study the association between long term treatment with acid suppressing drugs and the risk of oesophageal or gastric adenocarcinoma.

RESULTS: In 4 340 207 person years of follow up, 287 patients with oesophageal adenocarcinoma, 195 with gastric cardia adenocarcinoma, and 327 with gastric non-cardia adenocarcinoma were identified, and 10 000 control persons were randomly sampled.

"Oesophageal" indication for long term acid suppression (that is, reflux symptoms, oesophagitis, Barrett's oesophagus, or hiatal hernia) rendered a fivefold increased risk of oesophageal adenocarcinoma (odds ratio (OR) 5.42 (95% confidence interval (CI) 3.13-9.39)) while no association was observed among users with a group of other indications, including peptic ulcer and "gastroduodenal symptoms" (that is, gastritis, dyspepsia, indigestion, and epigastric pain) (OR 1.74 (95% CI 0.90-3.34)).

"Peptic ulcer" indication (that is, gastric ulcer, duodenal ulcer, or unspecified peptic ulcer) was associated with a greater than fourfold increased risk of gastric non-cardia adenocarcinoma among long term users (OR 4.66 (95% CI 2.42-8.97)) but no such association was found in those treated for a group of other indications (that is, "oesophageal" or "gastroduodenal symptoms") (OR 1.18 (95% CI 0.60-2.32)).

CONCLUSIONS: Long term pharmacological gastric acid suppression is a marker of increased risk of oesophageal and gastric adenocarcinoma.

[MeSH-major] Adenocarcinoma / chemically induced. Antacids / adverse effects. Esophageal Neoplasms / chemically induced. Stomach Neoplasms / chemically induced

[MeSH-minor] Adult. Aged. Aged, 80 and over. Anti-Ulcer Agents / administration & dosage. Anti-Ulcer Agents / adverse effects. Cardia. Drug Administration Schedule. Epidemiologic Methods. Great Britain / epidemiology. Histamine H2 Antagonists / administration & dosage. Histamine H2 Antagonists / adverse effects. Humans. Middle Aged. Proton Pump Inhibitors

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(PMID = 16785284.001).

[ISSN] 0017-5749

[Journal-full-title] Gut

[ISO-abbreviation] Gut

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Antacids; 0 / Anti-Ulcer Agents; 0 / Histamine H2 Antagonists; 0 / Proton Pump Inhibitors

[Other-IDs] NLM/ PMC1860118