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[Title] Stromal regulatory T-cells are associated with a favourable prognosis in gastric cancer of the cardia.

We assessed the prognostic significance of tumour infiltrating lymphocytes (TIL) in intestinal-type gastric cardiac cancer.

CONCLUSION: Our results suggest that inflammatory processes within the tumour stroma of gastric intestinal-type adenocarcinomas located at the gastric cardia may affect outcome in two ways.

Thus, inhibition of Treg may not be a feasible treatment option in gastric adenocarcinoma.

[MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Cardia / pathology. Stomach Neoplasms / diagnosis. Stomach Neoplasms / pathology. Stromal Cells / pathology. T-Lymphocytes, Regulatory / pathology

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(PMID = 19732435.001).

[ISSN] 1471-230X

[Journal-full-title] BMC gastroenterology

[ISO-abbreviation] BMC Gastroenterol

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / FOXP3 protein, human; 0 / Forkhead Transcription Factors

[Other-IDs] NLM/ PMC2749861

   

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[Title] [Diagnosis and long-term results of surgical resection of early cardiac adenocarcinoma].

OBJECTIVE: To summarize therapeutic experience and the long-term results of early cardiac adenocarcinoma with surgical resection.

METHODS: Ninety cases were diagnosed with early cardiac adenocarcinoma during endoscopic screening in high incidence rate area of esophageal cancer from 1972 to 1997.

Cardiectomy included partial stomach and esophagus was performed through left thoracotomy in all patients.

[MeSH-major] Adenocarcinoma / surgery. Cardia. Stomach Neoplasms / surgery

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(PMID = 19094526.001).

[ISSN] 0529-5815

[Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]

[ISO-abbreviation] Zhonghua Wai Ke Za Zhi

[Language] chi

[Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] China

   

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[Title] Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study.

The risk of gastric cancer (GC) associated with dietary intake of nitrosodimethylamine (NDMA) and endogenous formation of nitroso compounds (NOCs) was investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC).

ENOC was significantly associated with non-cardia cancer risk (HR, 1.42; 95% CI, 1.14-1.78 for an increase of 40 microg/day) but not with cardia cancer (HR, 0.96; 95% CI, 0.69-1.33).

ENOC formation may account for our previously reported association between red and processed meat consumption and gastric cancer risk.

[MeSH-major] Adenocarcinoma / epidemiology. Diet. Nitrosamines / metabolism. Nitrosamines / pharmacology. Stomach Neoplasms / epidemiology

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(PMID = 16571648.001).

[ISSN] 0143-3334

[Journal-full-title] Carcinogenesis

[ISO-abbreviation] Carcinogenesis

[Language] eng

[Grant] United Kingdom / Wellcome Trust / /

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Nitrosamines; E1UOL152H7 / Iron; M43H21IO8R / Dimethylnitrosamine; PQ6CK8PD0R / Ascorbic Acid

   

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[Title] Pure hepatoid adenocarcinoma of the stomach with spleen and lymph-node metastases.

The authors report a rare case of hepatoid adenocarcinoma of the stomach, presenting initially with spleen and lymph node metastases.

[MeSH-major] Adenocarcinoma / diagnosis. Cardia. Liver Neoplasms / diagnosis. Lymph Nodes / pathology. Splenic Neoplasms / diagnosis. Stomach Neoplasms / diagnosis

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[Copyright] Copyright 2010 Elsevier Inc. All rights reserved.

(PMID = 20359564.001).

[ISSN] 1879-1883

[Journal-full-title] American journal of surgery

[ISO-abbreviation] Am. J. Surg.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha-Fetoproteins; 8001-40-9 / Iodized Oil; 80168379AG / Doxorubicin

   

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[Title] Feasibility of sentinel node concept in gastric carcinoma: clinicopathological analysis of gastric cancer with solitary lymph node metastases.

BACKGROUND: The feasibility and diagnostic reliability of sentinel lymph node biopsy of gastric carcinoma are still unclear and controversial.

PATIENTS AND METHODS: To assess the applicability of the sentinel node concept to gastric carcinoma, we retrospectively analyzed the location of metastatic lymph nodes in patients with only one or two lymph node metastases.

RESULTS: A total of 135 patients, who underwent gastrectomy with D2 lymphadenectomy for primary gastric adenocarcinoma between 1997 and 2001, were enrolled in this study.

Skip metastases were only seen in one patient with cardia carcinoma and lymph node involvement of compartment II (left gastric artery).

CONCLUSION: In patients with gastric carcinoma, especially in early stage carcinoma, the phenomenon of skip metastasis is infrequent.

Therefore, the sentinel node concept may be feasible in gastric cancer.

[MeSH-major] Sentinel Lymph Node Biopsy. Stomach Neoplasms / diagnosis

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(PMID = 15865090.001).

[ISSN] 0250-7005

[Journal-full-title] Anticancer research

[ISO-abbreviation] Anticancer Res.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Greece

   

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[Title] Histochemical studies on intestinal metaplasia adjacent to gastric cardia adenocarcinoma in subjects at high-incidence area in Henan, north China.

AIM: To characterize the histochemical type and pattern of intestinal metaplasia (IM) adjacent to gastric cardia adenocarcinoma (GCA) and distal gastric cancer (GC) in Linzhou, Henan Province, China.

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(PMID = 16094701.001).

[ISSN] 1007-9327

[Journal-full-title] World journal of gastroenterology

[ISO-abbreviation] World J. Gastroenterol.

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / R01 CA065871; United States / NCI NIH HHS / CA / CA65871

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

[Publication-country] United States

[Other-IDs] NLM/ PMC4615402

   

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[Title] Tamoxifen exposure and risk of oesophageal and gastric adenocarcinoma: a population-based cohort study of breast cancer patients in Sweden.

Standardised incidence ratios (SIRs) of oesophageal and gastric cancer represented relative risks.

Among 138 885 cohort members contributing with 1 075 724 person-years of follow-up, we found a nonsignificantly increased risk of oesophageal adenocarcinoma during the potential tamoxifen exposure period (SIR 1.60, 95% confidence interval (CI) 0.83-3.08), but the risk estimates decreased with increasing latency interval.

No increased risk of cardia adenocarcinoma was identified in either period.

The risk of non-cardia gastric adenocarcinoma was increased in the potential tamoxifen period (SIR 1.27, 1.03-1.57), and almost doubled (SIR 1.86, 95% CI 1.10-3.14) in the period of longest latency (10-14 years).

We concluded that there might be a link between tamoxifen and risk of non-cardia gastric adenocarcinoma.

[MeSH-major] Adenocarcinoma / chemically induced. Breast Neoplasms / drug therapy. Carcinoma, Squamous Cell / chemically induced. Esophageal Neoplasms / chemically induced. Lung Neoplasms / chemically induced. Stomach Neoplasms / chemically induced. Tamoxifen / adverse effects

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(PMID = 16755290.001).

[ISSN] 0007-0920

[Journal-full-title] British journal of cancer

[ISO-abbreviation] Br. J. Cancer

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 094ZI81Y45 / Tamoxifen

[Other-IDs] NLM/ PMC2360495

   

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[Title] Plasma and dietary carotenoid, retinol and tocopherol levels and the risk of gastric adenocarcinomas in the European prospective investigation into cancer and nutrition.

Despite declining incidence rates, gastric cancer (GC) is a major cause of death worldwide.

The objective of this study was to determine the association of plasma levels of seven common carotenoids, their total plasma concentration, retinol and alpha- and gamma-tocopherol, with the risk of gastric adenocarcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), a large cohort involving 10 countries.

A secondary objective was to determine the association of total sum of carotenoids, retinol and alpha-tocopherol on GCs by anatomical subsite (cardia/noncardia) and histological subtype (diffuse/intestinal).

[MeSH-major] Adenocarcinoma / epidemiology. Carotenoids / administration & dosage. Diet. Stomach Neoplasms / epidemiology. Tocopherols / administration & dosage. Vitamin A / administration & dosage

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(PMID = 16832408.001).

[ISSN] 0007-0920

[Journal-full-title] British journal of cancer

[ISO-abbreviation] Br. J. Cancer

[Language] eng

[Grant] United Kingdom / Medical Research Council / / G0401527; United Kingdom / Wellcome Trust / /

[Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 11103-57-4 / Vitamin A; 1406-66-2 / Tocopherols; 36-88-4 / Carotenoids

[Other-IDs] NLM/ PMC2360629

   

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[Title] Sentinel node biopsy to evaluate the metastatic dissemination of oesophageal adenocarcinoma.

BACKGROUND: The aim of this study was to determine the feasibility and accuracy of sentinel lymph node (SLN) biopsy for oesophageal adenocarcinoma.

METHODS: Fifty-seven patients with adenocarcinoma of the lower oesophagus (n = 40) or gastric cardia (n = 17) underwent endoscopic peritumoral injection of (99m)Tc-radiolabelled nanocolloid before en bloc resection with extended lymphadenectomy.

Lower oesophageal tumours had a greater proportion of SLNs (P = 0.018), radioactive uptake (P < 0.001) and malignant nodes (P = 0.004) in the mediastinum than gastric cardia tumours.

CONCLUSION: The sentinel node concept is applicable to oesophageal adenocarcinoma and could be used to tailor the extent of lymphadenectomy.

There is a close relationship between patterns of radioactive uptake and lymphatic tumour dissemination, which differ for lower oesophageal and gastric cardia tumours.

[MeSH-major] Adenocarcinoma / secondary. Esophageal Neoplasms / pathology. Sentinel Lymph Node Biopsy / methods. Stomach Neoplasms / pathology

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(PMID = 15584066.001).

[ISSN] 0007-1323

[Journal-full-title] The British journal of surgery

[ISO-abbreviation] Br J Surg

[Language] eng

[Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

   

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BACKGROUND: The association of body mass index and gastroesophageal reflux disease (GERD), including its complications (esophagitis, Barrett esophagus, and esophageal adenocarcinoma), is unclear.

PURPOSE: To conduct a systematic review and meta-analysis to estimate the magnitude and determinants of an association between obesity and GERD symptoms, erosive esophagitis, Barrett esophagus, and adenocarcinoma of the esophagus and of the gastric cardia.

Six of 7 studies found significant associations of BMI with erosive esophagitis, 6 of 7 found significant associations with esophageal adenocarcinoma, and 4 of 6 found significant associations with gastric cardia adenocarcinoma.

Similarly, the pooled adjusted odds ratios for esophageal adenocarcinoma for BMI of 25 kg/m2 to 30 kg/m2 and BMI greater than 30 kg/m2 were 1.52 (CI, 1.147 to 2.009) and 2.78 (CI, 1.850 to 4.164), respectively.

CONCLUSION: Obesity is associated with a statistically significant increase in the risk for GERD symptoms, erosive esophagitis, and esophageal adenocarcinoma.

[MeSH-minor] Adenocarcinoma / etiology. Barrett Esophagus / etiology. Body Mass Index. Cardia. Esophageal Neoplasms / etiology. Esophagitis / etiology. Humans. Odds Ratio. Risk Factors

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(PMID = 16061918.001).

[ISSN] 1539-3704

[Journal-full-title] Annals of internal medicine

[ISO-abbreviation] Ann. Intern. Med.

[Language] eng

[Publication-type] Journal Article; Meta-Analysis; Research Support, U.S. Gov't, Non-P.H.S.

[Publication-country] United States

   

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[Title] Unchanging trend of esophagogastric junction adenocarcinoma in Korea: experience at a single institution based on Siewert's classification.

The incidence of adenocarcinoma of the esophagogastric junction (AEG) has been increasing in Western countries.

We retrospectively reviewed the medical records of 16 811 patients diagnosed with esophageal squamous cell carcinoma (ESC, n= 1450) or gastric noncardiac adenocarcinoma (GNCA, n= 14 751) between 1992 and 2006.

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(PMID = 19222529.001).

[ISSN] 1442-2050

[Journal-full-title] Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

[ISO-abbreviation] Dis. Esophagus

[Language] ENG

[Publication-type] Journal Article

[Publication-country] United States

   

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[Title] Endoscopic mucosal resection for staging and therapy of adenocarcinoma of the esophagus, gastric cardia, and upper gastric third.

Endoscopic submucosal dissection (ESD) is a useful therapeutic option for HGD or early cancer in the squamous epithelium of the esophagus or in the stomach when en bloc resection is needed in large lesions.

[MeSH-major] Adenocarcinoma / pathology. Cardia. Esophageal Neoplasms / pathology. Stomach Neoplasms / pathology

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(PMID = 20676873.001).

[ISSN] 0080-0015

[Journal-full-title] Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer

[ISO-abbreviation] Recent Results Cancer Res.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] Germany

   

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[Title] [Loss of heterozygosity at chromosome 8p21-p23 in adenocarcinoma of gastric cardia].

To investigate the involvement of the gene(s) in the carcinogenesis of adenocarcinoma of gastric cardia, loss of heterozygosity (LOH) for microsatellite markers at chromosome 8p21-p23 was examined.

Our data indicated that the tumor suppressor gene at chromosome 8p22 might play an important role in the development of adenocarcinoma of gastric cardia.

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(PMID = 16818423.001).

[ISSN] 0253-9772

[Journal-full-title] Yi chuan = Hereditas

[ISO-abbreviation] Yi Chuan

[Language] CHI

[Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] China

[Chemical-registry-number] 0 / DNA, Neoplasm

   

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[Title] [Understanding and controversy of the gastroesophageal junction adenocarcinoma].

[MeSH-major] Adenocarcinoma. Cardia. Esophageal Neoplasms. Esophagogastric Junction. Stomach Neoplasms

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(PMID = 19174001.001).

[ISSN] 0253-3766

[Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]

[ISO-abbreviation] Zhonghua Zhong Liu Za Zhi

[Language] chi

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review

[Publication-country] China

[Number-of-references] 23

   

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[Title] Detection of promoter hypermethylation of the CpG island of E-cadherin in gastric cardiac adenocarcinoma.

The aim of this study was to investigate the promoter methylation and expression of E-cadherin gene in gastric cardiac adenocarcinoma (GCA).

CONCLUSIONS: High methylation status of the 5' CpG island of E-cadherin gene may be one of the mechanisms in the development of gastric cardiac adenocarcinoma.

[MeSH-major] Adenocarcinoma / genetics. Cadherins / genetics. Cardia. CpG Islands. DNA Methylation. Promoter Regions, Genetic. Stomach Neoplasms / genetics

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[Cites] Br J Surg. 1998 Nov;85(11):1457-9 [9823902.001]

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(PMID = 19748854.001).

[ISSN] 0949-2321

[Journal-full-title] European journal of medical research

[ISO-abbreviation] Eur. J. Med. Res.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Germany

[Chemical-registry-number] 0 / Cadherins; 0 / RNA, Messenger

[Other-IDs] NLM/ PMC3352230

   

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[Title] Cancer of the gastric cardia.

Current evidence indicates that cardia cancers are of at least two distinct and disparate aetiologies.

One type resembles cancer of the more distal stomach (Type A), being a consequence of atrophic gastritis due to Helicobacter pylori infection or more rarely autoimmune atrophic gastritis.

Another type (Type B) resembles oesophageal adenocarcinoma and is likely to be a consequence of short-segment gastro-oesophageal reflux disease.

The two cancers are themselves indistinguishable but examination of the gastric phenotype indicates the aetiology: Type A occurring in patients with evidence of atrophic gastritis whereas Type B occurs in subjects with healthy acid secreting stomachs.

In subjects with healthy acid secreting stomachs the cardia has a specific luminal chemistry remaining highly acidic and unbuffered following a meal and having very active nitrosative chemistry due to the acidification of nitrite in saliva.

[MeSH-major] Adenocarcinoma / pathology. Cardia / pathology. Stomach Neoplasms / pathology

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(PMID = 16997153.001).

[ISSN] 1521-6918

[Journal-full-title] Best practice & research. Clinical gastroenterology

[ISO-abbreviation] Best Pract Res Clin Gastroenterol

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] England

[Number-of-references] 54

   

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[Title] Non-steroidal anti-inflammatory drugs and risk of gastric and oesophageal adenocarcinomas: results from a cohort study and a meta-analysis.

Use of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) may reduce the risk of gastric or oesophageal adenocarcinomas.

We examined the association between self-reported use of aspirin or non-aspirin NSAIDs in the earlier 12 months and gastric non-cardia (N=182), gastric cardia (N=178), and oesophageal adenocarcinomas (N=228) in a prospective cohort (N=311 115) followed for 7 years.

Use of any aspirin (HR, 95% CI: 0.64, 0.47-0.86) or other NSAIDs (0.68, 0.51-0.92) was associated with a significantly lower risk of gastric non-cardia adenocarcinoma.

Neither aspirin (0.86, 0.61-1.20) nor other NSAIDs (0.91, 0.67-1.22) had a significant association with gastric cardia cancer.

We found no significant association between using aspirin (1.00, 0.73-1.37) or other NSAIDs (0.90, 69-1.17) and oesophageal adenocarcinoma.

We also performed a meta-analysis of the association between the use of NSAIDs and risk of gastric and oesophageal adenocarcinoma.

In this analysis, aspirin use was inversely associated with both gastric and oesophageal adenocarcinomas, with summary odds ratios (95% CI) for non-cardia, cardia, and oesophageal adenocarcinomas of 0.64 (0.52-0.80), 0.82 (0.65-1.04), and 0.64 (0.52-0.79), respectively.

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(PMID = 19156150.001).

[ISSN] 1532-1827

[Journal-full-title] British journal of cancer

[ISO-abbreviation] Br. J. Cancer

[Language] ENG

[Grant] United States / Intramural NIH HHS / /

[Publication-type] Journal Article; Meta-Analysis; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.

[Publication-country] England

[Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal

[Other-IDs] NLM/ PMC2658549

   

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[Title] Dietary patterns and gastric cancer in a Portuguese urban population.

We aimed to quantify the association between dietary patterns and gastric cancer, by location and histological type, according to Helicobacter pylori infection status.

We analyzed 591 incident cases of gastric adenocarcinoma and 1,463 community controls.

Compared to pattern I, the risk of gastric cancer was higher for pattern II (OR = 1.68, 95% CI: 1.31-2.14) but not for pattern III (OR = 0.80, 95% CI: 0.57-1.14), with no effect modification by H. pylori infection.

The association was similar for cardia and non-cardia gastric cancer, but for tumors of the diffuse Laurén histological type, the association was weaker for pattern II vs. I (OR = 1.32, 95% CI: 0.83-2.08) and a protective effect was observed for pattern III vs. I (OR = 0.43, 95% CI: 0.22-0.87).

[MeSH-major] Adenocarcinoma / epidemiology. Diet. Stomach Neoplasms / epidemiology. Urban Population / statistics & numerical data

[MeSH-minor] Adult. Aged. Aged, 80 and over. Cardia. Case-Control Studies. Female. Helicobacter Infections / complications. Helicobacter Infections / microbiology. Helicobacter pylori / isolation & purification. Humans. Male. Middle Aged. Nutrition Surveys. Portugal / epidemiology. Prognosis. Surveys and Questionnaires. Young Adult

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(PMID = 19876925.001).

[ISSN] 1097-0215

[Journal-full-title] International journal of cancer

[ISO-abbreviation] Int. J. Cancer

[Language] eng

[Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't

[Publication-country] United States

   

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[Title] Clinical staging of adenocarcinoma of the esophagogastric junction.

Upper endoscopy establishes the tumor diagnosis by multiple biopsies and defines the tumor type (Siewert I-III), based on tumor localization in relation to the endoscopic cardia.

[MeSH-major] Adenocarcinoma / pathology. Esophageal Neoplasms / pathology. Esophagogastric Junction. Stomach Neoplasms / pathology

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(PMID = 20676872.001).

[ISSN] 0080-0015

[Journal-full-title] Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer

[ISO-abbreviation] Recent Results Cancer Res.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] Germany

   

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[Title] Cigarette smoking, body mass index, gastro-esophageal reflux disease, and non-steroidal anti-inflammatory drug use and risk of subtypes of esophageal and gastric cancers by P53 overexpression.

A number of risk factors for esophageal and gastric cancers have emerged, yet little is known whether risk factors map to molecular tumor markers such as overexpression of the tumor suppressor TP53.

Using a US multicenter, population-based case-control study (170 cases of esophageal adenocarcinomas, 147 gastric cardia adenocarcinomas, 220 non-cardia gastric adenocarcinomas, and 112 esophageal squamous cell carcinomas), we examined whether the risk associated with cigarette smoking, body mass index (BMI), gastroesophageal reflux disease (GERD), and non-steroidal anti-inflammatory drug (NSAID) use varied by P53 overexpression.

The proportion of cases overexpressing P53 by tumor subtype was 72% for esophageal adenocarcinoma, 69% for gastric cardia adenocarcinoma, 52% for non-cardia gastric adenocarcinoma, and 67% for esophageal squamous cell carcinoma.

For non-cardia gastric cancer however, an association with cigarette smoking was suggested for tumors that do not overexpress P53, whereas larger BMI was related to adenocarcinomas that overexpress P53 versus no overexpression.

Overall, this study did not find a clear relationship between P53 protein overexpression and the known risk factors for subtypes of esophageal and gastric cancers.

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(PMID = 18989634.001).

[ISSN] 1573-7225

[Journal-full-title] Cancer causes & control : CCC

[ISO-abbreviation] Cancer Causes Control

[Language] ENG

[Grant] None / None / / U01 CA057923-03; United States / NCI NIH HHS / CA / U01 CA057949; United States / NCI NIH HHS / CA / U01 CA057983; None / None / / U01 CA057983-03; United States / Intramural NIH HHS / / Z01 CP010136-12; United States / NCI NIH HHS / CA / U01 CA057923; United States / NCI NIH HHS / CA / U01 CA 57923; United States / NCI NIH HHS / CA / U01 CA057949-03; United States / NCI NIH HHS / CA / U01 CA057923-03; United States / NCI NIH HHS / CA / U01 CA057983-03; United States / NCI NIH HHS / CA / U01 CA 57983; United States / NCI NIH HHS / CA / U01 CA 57049; None / None / / U01 CA057949-03

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural

[Publication-country] Netherlands

[Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Tumor Suppressor Protein p53

[Other-IDs] NLM/ NIHMS100106; NLM/ PMC2726999

   

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[Title] Total gastrectomy for gastric carcinoma.

BACKGROUND/AIMS: Gastric cancer is one of the most common organ cancers all around the world and surgical resection is essential for treatment.

Total gastrectomy is the procedure of choice for treatment of proximal gastric cancer.

METHODOLOGY: Thirty-eight gastric cancer patients underwent total gastrectomy in the Third Surgical Clinic of Izmir Ataturk Training and Research Hospital between 1996 and 2001.

Sites of the tumors were: cardia 28.9%, cardia and corpus 15.8%, corpus 34.3%, corpus and antrum 18.4%, linitis plastica 2.6%.

Histological types were adenocarcinoma (97.4%), and squamous cell carcinoma (2.6%).

Gastric tubes were removed on the fourth postoperative day.

[MeSH-major] Adenocarcinoma / surgery. Carcinoma, Squamous Cell / surgery. Gastrectomy. Stomach Neoplasms / surgery

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(PMID = 15783055.001).

[ISSN] 0172-6390

[Journal-full-title] Hepato-gastroenterology

[ISO-abbreviation] Hepatogastroenterology

[Language] eng

[Publication-type] Journal Article

[Publication-country] Greece

   

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[MeSH-major] Adenocarcinoma / chemically induced. Antacids / adverse effects. Esophageal Neoplasms / chemically induced. Stomach Neoplasms / chemically induced

[MeSH-minor] Anti-Ulcer Agents / adverse effects. Cardia. Humans. Research Design

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[Cites] Gut. 2003 Jul;52(7):942-6 [12801948.001]

[Cites] Br Med J (Clin Res Ed). 1983 May 28;286(6379):1713-6 [6405946.001]

[CommentOn] Gut. 2006 Nov;55(11):1538-44 [16785284.001]

(PMID = 17566037.001).

[ISSN] 0017-5749

[Journal-full-title] Gut

[ISO-abbreviation] Gut

[Language] eng

[Publication-type] Comment; Letter

[Publication-country] England

[Chemical-registry-number] 0 / Antacids; 0 / Anti-Ulcer Agents

[Other-IDs] NLM/ PMC1994362

   

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[Title] Prevalence patterns of gastric cancers in Turkey: model of a developing country with high occurrence of Helicobacter pylori.

AIM: In developed countries, there has been a recent increase in the prevalence of adenocarcinoma of the esophagus and cardia, along with a decrease in distal gastric cancers.

The aim of the present study was to evaluate changes in the prevalence of gastric adenocarcinomas in Turkey as a function of anatomic location.

Owing to the exclusion criteria, a total of 4065 cases of tumors of the stomach and distal esophagus were included.

The ratio of distal/proximal adenocarcinoma was 2,1 [corrected] for the western part of Turkey and 3,8 [corrected] for the eastern part of the country (P < 0.0001), and this did not change during the 11 years. H. pylori was detected significantly less in the west compared to the east for distal tumors (65.7 vs 38.7%, respectively, P = 0.02).

CONCLUSION: In Turkey, a developing country with a high H. pylori prevalence, contrary to the state of developed countries, the ratio of distal versus proximal gastric adenocarcinomas has not changed.

Geographical distribution should be taken into the account in projecting the changing patterns of gastric cancers.

[MeSH-major] Developing Countries. Helicobacter pylori. Stomach Neoplasms / epidemiology. Stomach Neoplasms / microbiology

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[ErratumIn] J Gastroenterol Hepatol. 2008 Aug;23(8 Pt 1):1309

(PMID = 18031388.001).

[ISSN] 0815-9319

[Journal-full-title] Journal of gastroenterology and hepatology

[ISO-abbreviation] J. Gastroenterol. Hepatol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Australia

   

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[Title] Spleen preservation in radical surgery for gastric cardia cancer.

BACKGROUND: In gastric cardia cancer (GCC), the spleen is usually removed when the tumor is resected.

The purpose of this study was to investigate the effect of spleen preservation on survival following radical resection for gastric cardia cancer.

CONCLUSIONS: Splenectomy does not improve survival of patients who undergo curative resection for gastric cardia cancer.

[MeSH-major] Adenocarcinoma / surgery. Cardia. Spleen / physiology. Stomach Neoplasms / surgery

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(PMID = 17265118.001).

[ISSN] 1068-9265

[Journal-full-title] Annals of surgical oncology

[ISO-abbreviation] Ann. Surg. Oncol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

   

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[Title] Prospective study of physical activity and risk of primary adenocarcinomas of the oesophagus and stomach in the EPIC (European Prospective Investigation into Cancer and nutrition) cohort.

OBJECTIVE: To analyse the association between types of physical activity (occupational, recreational and household, vigorous and overall) and risk of primary oesophageal (OAC) or gastric adenocarcinoma (GAC).

Analyses were repeated by tumour site (cardia/non-cardia) and histological type (intestinal/diffuse).

A lower risk of overall and non-cardia GAC was found for increasing levels of a PA index which combined occupational PA with weekly time spent in sports and cycling.

The hazard ratio (HR) of GAC was 0.69, 95% CI: 0.50-0.94, for the comparison between active and inactive participants according to the PA index (HR = 0.44, 95% CI:0.26-0.74, for non-cardia GAC).

No effect was found for cardia tumours or histological subtypes of GAC.

CONCLUSIONS: Overall and distal (non-cardia) gastric tumours were inversely associated with time spent on cycling and sports and a total PA index.

No association was found for any type of PA and risk of cardia cancers of the stomach.

[MeSH-major] Adenocarcinoma / epidemiology. Esophageal Neoplasms / epidemiology. Exercise. Health Behavior. Nutrition Surveys. Stomach Neoplasms / epidemiology

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(PMID = 20052611.001).

[ISSN] 1573-7225

[Journal-full-title] Cancer causes & control : CCC

[ISO-abbreviation] Cancer Causes Control

[Language] eng

[Grant] United Kingdom / Medical Research Council / / G0401527; United Kingdom / Medical Research Council / / MC/ U106179471; United Kingdom / Medical Research Council / / ; United Kingdom / Cancer Research UK / /

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Netherlands

   

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[Title] Gastric metastases. An endoscopic series of ten cases.

We report a series of ten cases of the clinical, endoscopic and pathological features of gastric metastases.

Patients were six women and four men between 54 and 88 years old, with gastric metastases from breast carcinoma (4), lung carcinoma (4) and melanoma (2).

Metastases were located in the cardia (2), fundus (5) and antrum (3).

The microscopic features of the gastric metastases resembled a primary gastric cancer in eight cases.

Thanks to clinical data, the pathologist confirmed the diagnosis of gastric metastases on immunohistochemistry.

Gastric metastases are rare, occur at a late stage of the neoplastic disease, and have a poor prognosis.

Diagnosis of gastric metastases is difficult because they simulate primary gastric cancer on endoscopy and on microscopic examination.

[MeSH-major] Endoscopy, Gastrointestinal. Stomach Neoplasms / pathology. Stomach Neoplasms / secondary

[MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Aged. Aged, 80 and over. Carcinoma, Lobular / pathology. Carcinoma, Lobular / secondary. Female. Humans. Male. Middle Aged. Tomography, X-Ray Computed

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(PMID = 20627637.001).

[ISSN] 0399-8320

[Journal-full-title] Gastroentérologie clinique et biologique

[ISO-abbreviation] Gastroenterol. Clin. Biol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] France

   

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[Title] Transhiatal esophagectomy for distal and cardia cancers: implications of a positive gastric margin.

BACKGROUND: A common operation for cancer of the esophagus and cardia consists of transhiatal esophagectomy, proximal gastrectomy, and a cervical esophagogastric anastomosis.

The oncologic adequacy of dividing the stomach 4 to 6 cm distal to palpable tumor is not well documented, and when a positive gastric margin is present on the final pathologic analysis, the appropriate management is not established.

This study was undertaken to determine the incidence of a positive gastric margin in these patients and the impact of adjuvant treatment.

METHODS: A retrospective review was performed of 1044 patients undergoing transhiatal esophagectomy for adenocarcinoma of the distal esophagus or cardia.

Twenty (1.9%) had a positive gastric margin on final the pathologic evaluation and met inclusion criteria for this study.

CONCLUSIONS: A transhiatal esophagectomy and proximal gastrectomy for carcinoma of the distal esophagus and cardia, dividing the stomach 4 to 6 cm from palpable tumor, provides a negative gastric margin in 98% of patients.

In the few patients who have a positive gastric margin, 80% die with distant metastases, which would not be influenced by more extensive gastric resection, and in about 20%, local tumor recurrence develops in the intrathoracic stomach, seldom causing dysphagia.

Adjuvant therapy for a positive gastric margin neither improves survival nor reduces local tumor recurrence.

[MeSH-major] Adenocarcinoma / surgery. Esophageal Neoplasms / surgery. Esophagectomy / methods. Stomach Neoplasms / surgery

[MeSH-minor] Anastomosis, Surgical. Cardia / surgery. Combined Modality Therapy. Deglutition Disorders / prevention & control. Esophagus / surgery. Gastrectomy / methods. Humans. Neoplasm Recurrence, Local / prevention & control. Retrospective Studies. Stomach / surgery. Survival Analysis

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(PMID = 17532385.001).

[ISSN] 1552-6259

[Journal-full-title] The Annals of thoracic surgery

[ISO-abbreviation] Ann. Thorac. Surg.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Netherlands

   

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[Title] Gastric carcinoma: 5 year experience of a single institute.

PURPOSE: Gastric cancer (GC) is the most common cause of cancer death registered in cancer institute.

Most common site of involvement was cardia (43%).

[MeSH-major] Adenocarcinoma / therapy. Stomach Neoplasms / therapy

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(PMID = 16101332.001).

[ISSN] 1513-7368

[Journal-full-title] Asian Pacific journal of cancer prevention : APJCP

[ISO-abbreviation] Asian Pac. J. Cancer Prev.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Thailand

   

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[Title] [Association of polymorphisms of p21cip1 and p27kip1 genes with susceptibilities of esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma].

This study was to investigate the possible association of functional polymorphisms of p21(cip1) and p27(kip1) genes with susceptibilities of esophageal squamous cell carcinoma (ESCC) and gastric cardiac adenocarcinoma (GCA) in a population from a high incidence region in north China.

[MeSH-major] Cyclin-Dependent Kinase Inhibitor p21 / genetics. Cyclin-Dependent Kinase Inhibitor p27 / genetics. Esophageal Neoplasms / genetics. Polymorphism, Single Nucleotide / genetics. Stomach Neoplasms / genetics

[MeSH-minor] Adenocarcinoma / genetics. Carcinoma, Squamous Cell / genetics. Cardia. Female. Gene Frequency. Genetic Predisposition to Disease. Genotype. Humans. Male. Middle Aged. Smoking

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(PMID = 16480585.001).

[Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer

[ISO-abbreviation] Ai Zheng

[Language] chi

[Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] China

[Chemical-registry-number] 0 / CDKN1A protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p21; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27

   

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[MeSH-minor] Adenocarcinoma / complications. Aged. Cardia. Fatal Outcome. Humans. Hypertrophy. Immunohistochemistry. Male. Skin / pathology. Stomach Neoplasms / metabolism

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(PMID = 19688170.001).

[ISSN] 1651-2057

[Journal-full-title] Acta dermato-venereologica

[ISO-abbreviation] Acta Derm. Venereol.

[Language] eng

[Publication-type] Case Reports; Letter

[Publication-country] Sweden

[Chemical-registry-number] EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3

   

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[Title] Association of ablation of Barrett's esophagus with high grade dysplasia and adenocarcinoma of the gastric cardia.

Three cases are reported in which the patient developed adenocarcinoma of the gastric cardia after thermal ablation of HGD.

Three cases are reported with long-segment BE and a nodule or mass in the endoscopic cardia post-thermal ablation.

Biopsies documented adenocarcinoma of the gastric cardia.

The development of adenocarcinoma of the cardia is unexpected.

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(PMID = 16866860.001).

[ISSN] 1120-8694

[Journal-full-title] Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

[ISO-abbreviation] Dis. Esophagus

[Language] ENG

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

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[Title] DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study.

BACKGROUND: The contribution of genetic variation in DNA repair genes to gastric cancer (GC) risk remains essentially unknown.

Method A nested case control study within the EPIC cohort was performed including 246 gastric adenocarcinomas and 1175 matched controls.

RESULTS: No association was observed for any of these polymorphisms with stomach cancer risk.

This is the first prospective study suggesting that individual variation in DNA repair may be relevant for gastric carcinogenesis, a finding that will require further confirmation validation in larger independent studies.

[MeSH-major] Adenocarcinoma / genetics. DNA Repair / genetics. Gastritis, Atrophic / genetics. Polymorphism, Genetic. Stomach Neoplasms / genetics

[MeSH-minor] Adult. Aged. Antibodies, Bacterial / blood. Biomarkers / blood. Cardia / pathology. Case-Control Studies. Chronic Disease. Europe. Female. Follow-Up Studies. Gene Frequency. Genes, p53. Genetic Predisposition to Disease. Helicobacter Infections / complications. Helicobacter Infections / immunology. Helicobacter pylori / immunology. Humans. Male. Middle Aged. Odds Ratio. Pepsinogen A / blood. Prospective Studies. Risk. Xeroderma Pigmentosum Group D Protein / genetics

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(PMID = 18641418.001).

[ISSN] 1464-3685

[Journal-full-title] International journal of epidemiology

[ISO-abbreviation] Int J Epidemiol

[Language] eng

[Grant] United Kingdom / British Heart Foundation / / ; United Kingdom / Cancer Research UK / / ; United Kingdom / Medical Research Council / / ; United Kingdom / Wellcome Trust / /

[Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Antibodies, Bacterial; 0 / Biomarkers; 9001-10-9 / Pepsinogen A; EC 3.6.4.12 / Xeroderma Pigmentosum Group D Protein; EC 5.99.- / ERCC2 protein, human

   

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[Title] A positive family history of esophageal/gastric cardia cancer with gastric cardia adenocarcinoma is associated with a younger age at onset and more likely with another synchronous esophageal/gastric cardia cancer in a Chinese high-risk area.

BACKGROUND: To find a genetic component in gastric cardia adenocarcinomas (GCA).

[MeSH-major] Adenocarcinoma / genetics. Asian Continental Ancestry Group. Cardia / pathology. Esophageal Neoplasms / genetics. Neoplasms, Multiple Primary / pathology. Stomach Neoplasms / genetics

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[Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.

(PMID = 20603233.001).

[ISSN] 1878-0849

[Journal-full-title] European journal of medical genetics

[ISO-abbreviation] Eur J Med Genet

[Language] eng

[Publication-type] Journal Article

[Publication-country] Netherlands

   

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[Title] Immunohistochemical and quantitative mRNA assessment of ghrelin expression in gastric and oesophageal adenocarcinoma.

BACKGROUND: Ghrelin is an orexigenic gut peptide produced predominantly by the stomach.

Gastric mucosal ghrelin production could be compromised by an infiltrating adenocarcinoma.

METHODS: 10 gastric and 22 oesophageal adenocarcinoma archival samples were randomly selected from a database.

Quantitative reverse transcriptase polymerase chain reaction (PCR) for ghrelin mRNA was also performed on 24 gastric and 8 oesophageal adenocarcinoma specimens and adjacent non-neoplastic mucosa.

RESULTS: Immunohistochemistry and reverse transcriptase PCR confirm a negligible expression of ghrelin in adenocarcinoma specimens.

By contrast, non-neoplastic gastric mucosa was rich in ghrelin-positive cells and ghrelin mRNA.

The number (median and range) of ghrelin-positive cells per 2 mm section of non-neoplastic mucosa was 73 (45-215) in the corpus; this was significantly higher than in cardia mucosa (9 (0-64), p<0.001) and antral mucosa (5 (0-14), p<0.001).

CONCLUSIONS: Gastric and oesophageal adenocarcinomas have no ghrelin-producing cells.

The highest level of ghrelin expression was noted in the non-neoplastic mucosa of the gastric corpus.

Disruption of the gastric ghrelin-producing mechanism may occur during oesophagogastric malignancy.

[MeSH-major] Adenocarcinoma / metabolism. Esophageal Neoplasms / metabolism. Peptide Hormones / biosynthesis. Stomach Neoplasms / metabolism

[MeSH-minor] Gastric Mucosa / metabolism. Ghrelin. Humans. Immunoenzyme Techniques. Neurosecretory Systems / metabolism. RNA, Messenger / genetics. RNA, Neoplasm / genetics. Reverse Transcriptase Polymerase Chain Reaction / methods

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(PMID = 16751299.001).

[ISSN] 0021-9746

[Journal-full-title] Journal of clinical pathology

[ISO-abbreviation] J. Clin. Pathol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Chemical-registry-number] 0 / Ghrelin; 0 / Peptide Hormones; 0 / RNA, Messenger; 0 / RNA, Neoplasm

[Other-IDs] NLM/ PMC2001112

   

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[Title] [Correlation of 53BP1 and p53 polymorphisms to susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma].

This study was to investigate the correlation of 53BP1 and p53 SNPs to susceptibility to esophageal squamous cell carcinoma (ESCC) and gastric cardiac adenocarcinoma (GCA) in a high incidence area of Hebei Province in China.

[MeSH-major] Cardia. Esophageal Neoplasms / genetics. Intracellular Signaling Peptides and Proteins / genetics. Polymorphism, Single Nucleotide. Stomach Neoplasms / genetics. Tumor Suppressor Protein p53 / genetics

[MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / genetics. Adenocarcinoma / metabolism. Adult. Aged. Aged, 80 and over. Alleles. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / genetics. Carcinoma, Squamous Cell / metabolism. China / epidemiology. Female. Gene Frequency. Genetic Predisposition to Disease. Genotype. Humans. Male. Middle Aged

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(PMID = 17927872.001).

[Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer

[ISO-abbreviation] Ai Zheng

[Language] chi

[Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] China

[Chemical-registry-number] 0 / Intracellular Signaling Peptides and Proteins; 0 / TP53BP1 protein, human; 0 / Tumor Suppressor Protein p53

   

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[Title] Allelic imbalance on distal 7q (7q36.1-q36.3) in gastric cardia and oesophageal (Barrett's) adenocarcinoma.

BACKGROUND: Oesophageal (Barrett's) and gastric cardia adenocarcinomas are cancers arising at and around the gastro-oesophageal junction.

In addition, 40 gastric cardia cancers were investigated to compare the pattern of imbalance at these loci.

RESULTS: Overall, the number of allelic loss was higher in Barrett's cancers than in gastric cardia carcinomas (p=0.04).

In gastric cardia cancers, loss ranged from 12% to 27% (of informative cases), being most frequent at marker D7S3037.

The difference between oesophageal and gastric adenocarcinomas was highest for polymorphic marker D7S483 (p=0.05).

CONCLUSION: Marker D7S483 can aid in discriminating oesophageal (Barrett's) and gastric cardia carcinomas.

[MeSH-major] Adenocarcinoma / genetics. Allelic Imbalance. Barrett Esophagus / genetics. Cardia / pathology. Chromosomes, Human, Pair 7 / genetics. Esophageal Neoplasms / genetics. Stomach Neoplasms / genetics

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(PMID = 15868927.001).

[ISSN] 0250-7005

[Journal-full-title] Anticancer research

[ISO-abbreviation] Anticancer Res.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Greece

   

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[Title] A prospective study of tobacco, alcohol, and the risk of esophageal and gastric cancer subtypes.

Rates of esophageal adenocarcinoma and gastric cardia adenocarcinoma have increased, while rates of esophageal squamous cell carcinoma (ESCC) and gastric noncardia adenocarcinoma have decreased, suggesting distinct etiologies.

Between 1995/1996 and 2000, 97 incident cases of ESCC, 205 of esophageal adenocarcinoma, 188 of gastric cardia, and 187 of gastric noncardia cancer occurred.

Compared with nonsmokers, current smokers were at increased risk for ESCC (hazard ratio (HR) = 9.27, 95% confidence interval (CI): 4.04, 21.29), esophageal adenocarcinoma (HR = 3.70, 95% CI: 2.20, 6.22), gastric cardia (HR = 2.86, 95% CI: 1.73, 4.70), and gastric noncardia (HR = 2.04, 95% CI: 1.32, 3.16).

Assuming causality, ever smoking had population attributable risks of 77% (95% CI: 0.55, 0.89) for ESCC, 58% (95% CI: 0.38, 0.72) for esophageal adenocarcinoma, 47% (95% CI: 0.27, 0.63) for gastric cardia, and 19% (95% CI: 0.00, 0.37) for gastric noncardia.

For drinkers of more than three alcoholic beverages per day, compared with those whose intake was up to one drink per day, the authors found significant associations between alcohol intake and ESCC risk (HR = 4.93, 95% CI: 2.69, 9.03) but not risk for esophageal, gastric cardia, or gastric noncardia adenocarcinoma.

[MeSH-major] Adenocarcinoma / etiology. Alcohol Drinking / adverse effects. Carcinoma, Squamous Cell / etiology. Esophageal Neoplasms / etiology. Smoking / adverse effects. Stomach Neoplasms / etiology

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(PMID = 17420181.001).

[ISSN] 0002-9262

[Journal-full-title] American journal of epidemiology

[ISO-abbreviation] Am. J. Epidemiol.

[Language] eng

[Grant] United States / Intramural NIH HHS / /

[Publication-type] Journal Article; Research Support, N.I.H., Intramural

[Publication-country] United States

   

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[Title] Trends in incidence of oesophageal and stomach cancer subtypes in Europe.

OBJECTIVE: Time trend studies in the USA have shown that the incidences of adenocarcinomas of the oesophagus and gastric cardia have risen strongly since the 1970s, whereas the incidence of squamous cell carcinomas of the oesophagus has declined.

The main goal of this study was to investigate more recent trends in the incidence of oesophageal and stomach cancer subtypes in the European countries.

METHODS: Eurocim cancer incidence data of 23 cancer registries from 13 European countries were used to investigate the incidence trends in oesophageal and stomach cancer subtypes during the 1983-1997 period.

RESULTS: The incidence of adenocarcinomas of the oesophagus and gastric cardia rose in most, but not all, registration areas (EAPCs were usually 1-7%), the strongest in the UK and Ireland.

CONCLUSION: Our results are partly in line with earlier findings on adenocarcinomas of the oesophagus and gastric cardia.

[MeSH-major] Adenocarcinoma / epidemiology. Esophageal Neoplasms / epidemiology. Neoplasms, Squamous Cell / epidemiology. Stomach Neoplasms / epidemiology

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(PMID = 19474750.001).

[ISSN] 1473-5687

[Journal-full-title] European journal of gastroenterology & hepatology

[ISO-abbreviation] Eur J Gastroenterol Hepatol

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

   

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METHODS: Using PCR based restriction fragment length polymorphism and single strand conformational polymorphism, we determined single nucleotide exchanges in the p16 and cyclin D1 genes among 56 esophageal adenocarcinomas (ADC) arising in Barrett's esophagus, 95 cardiac gastric ADC, and in 191 distal gastric ADC.

RESULTS: The C/G genotype of p16 was identified in 10.4% of esophageal carcinomas, 13.3% of cardiac carcinomas, and in 14.1% of gastric carcinomas, compared to 17.4% in the healthy control group.

In distal gastric carcinoma, both homozygous genotypes (G/G and A/A) had a frequency of 15.2% each, while the heterozygous A/G genotype occurred in 69.6% of patients.

CONCLUSIONS: Our results show that frequencies of p16 or cyclin D1 polymorphisms in gastric and esophageal ADC do not differ significantly from the healthy control group.

[MeSH-major] Adenocarcinoma / genetics. Cyclin D1 / genetics. Cyclin-Dependent Kinase Inhibitor p16 / genetics. Esophageal Neoplasms / genetics. Polymorphism, Genetic. Stomach Neoplasms / genetics

[MeSH-minor] Adult. Aged. Aged, 80 and over. Alanine. Barrett Esophagus / complications. Cardia. Case-Control Studies. Cysteine. DNA, Neoplasm / analysis. Female. Gene Frequency. Glycine. Homozygote. Humans. Male. Middle Aged. Polymerase Chain Reaction. Polymorphism, Restriction Fragment Length. Polymorphism, Single Nucleotide. Polymorphism, Single-Stranded Conformational

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[Cites] Carcinogenesis. 2001 Aug;22(8):1195-9 [11470749.001]

[Cites] Oncology. 2001;61(1):1-9 [11474241.001]

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(PMID = 16163549.001).

[ISSN] 0171-5216

[Journal-full-title] Journal of cancer research and clinical oncology

[ISO-abbreviation] J. Cancer Res. Clin. Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Germany

[Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Neoplasm; 136601-57-5 / Cyclin D1; K848JZ4886 / Cysteine; OF5P57N2ZX / Alanine; TE7660XO1C / Glycine

   

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[Title] Helicobacter pylori, pepsinogen, and gastric adenocarcinoma in Hawaii.

BACKGROUND: The objective was to investigate the association of Helicobacter pylori and serum pepsinogen (PG) levels with gastric adenocarcinoma.

RESULTS: Subjects with low PG I levels or low PG I/II ratios were at increased risk for cardia and noncardia gastric cancer, whereas those with H. pylori or CagA seropositivity had an elevated risk for noncardia cancer only.

CONCLUSIONS: The results suggest that persons with both H. pylori or CagA seropositivity and a low PG I level or PG I/II ratio are highly susceptible to development of noncardia gastric cancer.

[MeSH-major] Adenocarcinoma / etiology. Helicobacter Infections / complications. Helicobacter pylori / pathogenicity. Pepsinogen A / blood. Stomach Neoplasms / etiology

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(PMID = 15897993.001).

[ISSN] 0022-1899

[Journal-full-title] The Journal of infectious diseases

[ISO-abbreviation] J. Infect. Dis.

[Language] eng

[Grant] United States / NCI NIH HHS / CA / P01 CA 33619

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.

[Publication-country] United States

[Chemical-registry-number] 0 / Antibodies, Bacterial; 0 / Antigens, Bacterial; 0 / Bacterial Proteins; 0 / cagA protein, Helicobacter pylori; 9001-10-9 / Pepsinogen A

   

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[Title] Risk of lymph node metastasis associated with deeper invasion by early adenocarcinoma of the esophagus and cardia: study based on endoscopic resection specimens.

BACKGROUND: Most risk estimations for lymph node metastasis in adenocarcinoma of the esophagus and cardia (AEC) with invasion into the muscularis mucosae (m3) or submucosa are based on surgical series.

[MeSH-major] Adenocarcinoma / secondary. Cardia / pathology. Esophageal Neoplasms / pathology. Mucous Membrane / pathology. Stomach Neoplasms / pathology

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[Copyright] © Georg Thieme Verlag KG Stuttgart · New York.

(PMID = 20960392.001).

[ISSN] 1438-8812

[Journal-full-title] Endoscopy

[ISO-abbreviation] Endoscopy

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Germany

   

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[Title] [Adenocarcinoma arising in gastroesophageal junction: a reappraisal].

[MeSH-major] Adenocarcinoma / pathology. Cardia. Esophageal Neoplasms / pathology. Esophagogastric Junction / pathology. Stomach Neoplasms / pathology

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(PMID = 17822618.001).

[ISSN] 0529-5807

[Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology

[ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi

[Language] chi

[Publication-type] Journal Article; Review

[Publication-country] China

[Number-of-references] 31

   

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[Title] Adenocarcinoma of the oesophagus and gastric cardia: male preponderance in association with obesity.

Recent evidence links obesity with the rising incidence of oesophageal adenocarcinoma.

In Ireland between 1995 and 2004 the incidence of oesophageal adenocarcinoma increased by 38%, and this coincided with a 67% increase in the prevalence of obesity.

In this study, a prospective case-control study was undertaken in 760 patients presenting to a tertiary centre between 1994 and 2004 diagnosed with cancer of the oesophagus, gastric cardia or stomach.

Based on pre-illness BMI, 82% of patients who developed adenocarcinoma of the oesophagus were either overweight or obese compared with 59% of the healthy control population (P<0.001).

A dose-dependent relationship existed between BMI and oesophageal adenocarcinoma in males.

Using common cut-off points for BMI, the OR of adenocarcinoma of the lower oesophagus was 11.3 times higher (95% CI: 3.5-36.4) for individuals with a BMI >30 kg/m2 versus individuals with a BMI <22 kg/m2 (P<0.001 for trend).

For adenocarcinoma of the gastric cardia, males in the top quartile of BMI had an OR of 3.5 (95% CI: 1.3-9.4) compared with the lowest quartile (P=0.03 for trend).

The odds ratio for adenocarcinoma of the oesophagus, the oesophago-gastric junction and gastric cardia rose significantly with increasing BMI.

[MeSH-major] Adenocarcinoma / etiology. Carcinoma, Squamous Cell / etiology. Cardia. Esophageal Neoplasms / etiology. Obesity / complications. Stomach Neoplasms / etiology

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(PMID = 16630714.001).

[ISSN] 0959-8049

[Journal-full-title] European journal of cancer (Oxford, England : 1990)

[ISO-abbreviation] Eur. J. Cancer

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

   

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[Title] Asia-Pacific consensus guidelines on gastric cancer prevention.

BACKGROUND AND AIM: Gastric cancer is a major health burden in the Asia-Pacific region but consensus on prevention strategies has been lacking.

We aimed to critically evaluate strategies for preventing gastric cancer.

RESULTS: Helicobacter pylori infection is a necessary but not sufficient causal factor for non-cardia gastric adenocarcinoma.

A high intake of salt is strongly associated with gastric cancer.

Fresh fruits and vegetables are protective but the use of vitamins and other dietary supplements does not prevent gastric cancer.

Host-bacterial interaction in H. pylori infection results in different patterns of gastritis and differences in gastric acid secretion which determine disease outcome.

A positive family history of gastric cancer is an important risk factor.

Low serum pepsinogens reflect gastric atrophy and may be useful as a marker to identify populations at high risk for gastric cancer. H. pylori screening and treatment is a recommended gastric cancer risk reduction strategy in high-risk populations. H. pylori screening and treatment is most effective before atrophic gastritis has developed.

It does not exclude the existing practice of gastric cancer surveillance in high-risk populations.

In populations at low risk for gastric cancer, H. pylori screening is not recommended.

CONCLUSION: A strategy of H. pylori screening and eradication in high-risk populations will probably reduce gastric cancer incidence, and based on current evidence is recommended by consensus.

[MeSH-major] Adenocarcinoma / prevention & control. Anticarcinogenic Agents / therapeutic use. Biomarkers, Tumor / analysis. Helicobacter Infections / drug therapy. Helicobacter pylori. Mass Screening. Stomach Neoplasms / prevention & control

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(PMID = 18318820.001).

[ISSN] 1440-1746

[Journal-full-title] Journal of gastroenterology and hepatology

[ISO-abbreviation] J. Gastroenterol. Hepatol.

[Language] eng

[Publication-type] Consensus Development Conference; Journal Article; Practice Guideline

[Publication-country] Australia

[Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Anticarcinogenic Agents; 0 / Biomarkers, Tumor; 0 / Pepsinogens; 0 / Sodium Chloride, Dietary; 0 / Vitamins; PQ6CK8PD0R / Ascorbic Acid

[Number-of-references] 140

   

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[Title] Association of functional polymorphisms in MMPs genes with gastric cardia adenocarcinoma and esophageal squamous cell carcinoma in high incidence region of North China.

The aim of the present study was to investigate the association of single nucleotide polymorphisms (SNPs) in matrix metalloproteinase (MMPs) with the risk of gastric cardia adenocarcinoma (GCA) and esophageal squamous cell carcinoma (ESCC).

[MeSH-major] Esophageal Neoplasms / epidemiology. Esophageal Neoplasms / genetics. Genetic Predisposition to Disease. Matrix Metalloproteinases / genetics. Polymorphism, Single Nucleotide / genetics. Stomach Neoplasms / epidemiology. Stomach Neoplasms / genetics

[MeSH-minor] Adenocarcinoma / enzymology. Adenocarcinoma / epidemiology. Adenocarcinoma / genetics. Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / enzymology. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / genetics. Case-Control Studies. China / epidemiology. Female. Gene Frequency / genetics. Haplotypes / genetics. Humans. Incidence. Male. Middle Aged

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[Cites] Int J Epidemiol. 2000 Aug;29(4):645-54 [10922340.001]

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(PMID = 19562509.001).

[ISSN] 1573-4978

[Journal-full-title] Molecular biology reports

[ISO-abbreviation] Mol. Biol. Rep.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Netherlands

[Chemical-registry-number] EC 3.4.24.- / Matrix Metalloproteinases

   

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[Title] Epidemiology of gastric cancer in Jos University Teaching Hospital Jos a 20 year review of cases.

BACKGROUND: Gastric cancer believed to be rare in the past in Africa, is now one of the leading cancer morbidity and mortality.

It is now known gastric cancer is 2-3 times higher in males than females living in the same environment.

We aim to describe the comprehensive histological characteristics of gastric cancer with age and sex distribution.

The study materials were obtained from all stained specimens of gastric cancer recorded in the histopathology laboratory of the teaching hospital between 1985 to 2004.

These were divided into the following groups: Cardia, body and an thrum/pyloric regions respectively.

RESULTS: There were a total of 205 gastric cancer histological confirmed, out of 5705 malignant tumours recorded in the same period.

The highest frequencies of gastric cancers were located in the anthral and cardia regions which accounted for 79% of all the tumours.

Well differentiated adenocarcinoma (intestinal type) was the most frequent histological subtypes 51.2%), this was followed by poorly and diffusely infiltrating carcinoma.

The study has also demonstrated H pylori at the background of intestinal type adenocarcinoma which was seen in the body and an thrum.

CONCLUSION: The study has shown that gastric cancer is not only common but it occur more males than females.

Therefore eradication of H pylori might reduce the prevalence of gastric carcinoma.

[MeSH-major] Carcinoma / epidemiology. Lymphoma, Non-Hodgkin / epidemiology. Stomach Neoplasms / epidemiology

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(PMID = 21526638.001).

[ISSN] 1115-2613

[Journal-full-title] Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria

[ISO-abbreviation] Niger J Med

[Language] eng

[Publication-type] Journal Article

[Publication-country] Nigeria

   

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[Title] Methylenetetrahydrofolate reductase polymorphisms/haplotypes and risk of gastric cancer: a case-control analysis in China.

Studies have suggested that low dietary folate intake is associated with an increased risk of gastric cancer.

C677T, A1298C and G1793A) and their haplotypes are associated with the risk of gastric cancer.

To test this hypothesis, we genotyped these polymorphisms in a population-based case-control study of 320 incident gastric adenocarcinoma cases and 313 cancer-free controls in a Chinese population.

Consistent with our previous observations, the 677TT genotype was associated with a significantly increased risk for gastric cancer (adjusted OR =1.79, 95% CI =1.02-3.15) compared with the 677CC genotype; the association was more evident for gastric cardia adenocarcinoma (adjusted OR =2.60, 95% CI =1.30-5.21).

When we used the haplotype analyses and assumed MTHFR 677T, 1298C and 1793A as risk alleles, individuals with 6 variant alleles had a significantly (4.64-fold) increased risk for gastric cardia adenocarcinoma (OR =4.64, 95% CI =1.34-16.01) compared with those having 0-2 variants.

These findings suggest that the MTHFR common variants and their haplotypes may play a role in the etiology of gastric cancer, particularly gastric cardia adenocarcinoma.

[MeSH-major] Adenocarcinoma / genetics. Methylenetetrahydrofolate Reductase (NADPH2) / genetics. Polymorphism, Genetic. Stomach Neoplasms / genetics

[MeSH-minor] Aged. Asian Continental Ancestry Group / genetics. Cardia. Case-Control Studies. China / epidemiology. Female. Gene Frequency. Genetic Predisposition to Disease. Haplotypes. Humans. Male. Middle Aged. Risk Factors

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(PMID = 15643524.001).

[ISSN] 1021-335X

[Journal-full-title] Oncology reports

[ISO-abbreviation] Oncol. Rep.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Greece

[Chemical-registry-number] EC 1.5.1.20 / Methylenetetrahydrofolate Reductase (NADPH2)

   

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[Title] Family history of cancer and risk for esophageal and gastric cancer in Shanxi, China.

METHODS: 600 esophageal squamous cell carcinoma (ESCC) cases, 598 gastric cardia adenocarcinoma cases, and 316 gastric non-cardia adenocarcinoma cases, and 1514 age-, gender-, and neighborhood-matched controls were asked for FH in first degree relatives and non-blood relatives.

FH of gastric cardia cancer was associated with an increased risk of all three cancers.

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(PMID = 19656375.001).

[ISSN] 1471-2407

[Journal-full-title] BMC cancer

[ISO-abbreviation] BMC Cancer

[Language] ENG

[Grant] United States / Intramural NIH HHS / /

[Publication-type] Journal Article; Research Support, N.I.H., Intramural

[Publication-country] England

[Other-IDs] NLM/ PMC2729777

   

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[Title] Expression of multidrug resistance-related proteins p-glycoprotein, glutathione-s-transferases, topoisomerase-II and lung resistance protein in primary gastric cardiac adenocarcinoma.

However, the clinical significance of the expression of MDR-related proteins p-glycoprotein (PGP), glutathione-s-transferases (GST-pi), topoisomerase-II (Topo-II) and lung resistance protein (LRP) in primary gastric cardiac adenocarcinoma (PGCA) remains unclear.

[MeSH-major] Adenocarcinoma / chemistry. Cardia / chemistry. DNA Topoisomerases, Type II / analysis. Glutathione S-Transferase pi / analysis. P-Glycoprotein / analysis. Stomach Neoplasms / chemistry. Vault Ribonucleoprotein Particles / analysis

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(PMID = 19102336.001).

[ISSN] 0172-6390

[Journal-full-title] Hepato-gastroenterology

[ISO-abbreviation] Hepatogastroenterology

[Language] eng

[Publication-type] Journal Article

[Publication-country] Greece

[Chemical-registry-number] 0 / P-Glycoprotein; 0 / Vault Ribonucleoprotein Particles; 0 / major vault protein; EC 2.5.1.18 / Glutathione S-Transferase pi; EC 5.99.1.3 / DNA Topoisomerases, Type II

   

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[Title] Trends in the incidence of adenocarcinoma of the oesophagus and cardia in the Netherlands 1989-2003.

Over the 15-year period 1989-2003, the incidence of oesophagus-cardia adenocarcinoma in the Netherlands rose annually by 2.6% for males and 1.2% for females.

This was the net outcome of annual increases in the incidence of adenocarcinoma of the oesophagus (ACO) of 7.2% for males and 3.5% for females and annual declines in the incidence of adenocarcinoma of the gastric cardia (AGC) of more than 1% for both genders.

[MeSH-major] Adenocarcinoma / epidemiology. Cardia. Esophageal Neoplasms / epidemiology. Stomach Neoplasms / epidemiology

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(PMID = 17505507.001).

[ISSN] 0007-0920

[Journal-full-title] British journal of cancer

[ISO-abbreviation] Br. J. Cancer

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Other-IDs] NLM/ PMC2359916

   

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[Title] Demographic and lifestyle predictors of survival in patients with esophageal or gastric cancers.

BACKGROUND AND AIMS: Risk factors for subtypes of esophageal and gastric cancer recently have been identified, but their effect on survival is unknown.

Cox regression models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for esophageal and gastric cancer in relation to prediagnostic factors.

RESULTS: Relative to distant stage, esophageal adenocarcinoma (EA) patients with localized disease had a decreased risk for death (HR, .22; 95% CI, .15-.31), followed by those with regional spread (HR, .32; 95% CI, .23-.45).

Except for other (non-cardia) gastric adenocarcinomas (OGA), higher household income (> or =15,000 US dollars/y vs. <15,000 US dollars/y) was associated with a 33%-38% decrease in risk for death.

CONCLUSIONS: Predictors of lengthened esophageal and gastric cancer survival included higher income (except in OGA), overweight (among EA and OGA patients), and female sex (among ES and OGA patients).

[MeSH-major] Adenocarcinoma / mortality. Carcinoma, Squamous Cell / mortality. Esophageal Neoplasms / mortality. Stomach Neoplasms / mortality

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(PMID = 15765441.001).

[ISSN] 1542-3565

[Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

[ISO-abbreviation] Clin. Gastroenterol. Hepatol.

[Language] eng

[Grant] United States / NCI NIH HHS / CN / N01-CN05230; United States / NCI NIH HHS / CP / N02-CP40501; United States / NIEHS NIH HHS / ES / P30ES10126; United States / NCI NIH HHS / CA / T32-CA09330; United States / NCI NIH HHS / CA / U01-CA57923; United States / NCI NIH HHS / CA / U01-CA57949; United States / NCI NIH HHS / CA / U01-CA57983

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.

[Publication-country] United States