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Items 1 to 11 of about 11
1. Pocard M, Bras-Gonçalves R, Hamelin R, Northover J, Poupon MF: Response to 5-fluorouracil of orthotopically xenografted human colon cancers with a microsatellite instability: influence of P53 status. Anticancer Res; 2000 Jan-Feb;20(1A):85-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Two hCC (TC82 and TC71) had a mutated p53 (mutp53), while two others (TC33 and LoVo) had a wild type p53 (wtp53); the fifth tumour (X17LoVo) originated from the stable transfection of LoVo cells with a dominant mutp53 (273his) vector.
  • All tumours were implanted onto the caecum of nude mice to induce orthotopic growth of hCC.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antimetabolites, Antineoplastic / therapeutic use. Colonic Neoplasms / drug therapy. Fluorouracil / therapeutic use. Genes, p53. Microsatellite Repeats
  • [MeSH-minor] Animals. Cecum. Drug Resistance, Neoplasm / genetics. Female. Genes, Dominant. Humans. Mice. Mice, Nude. Mutation. Neoplasm Transplantation. Phenotype. Transfection. Transplantation, Heterologous. Tumor Cells, Cultured / drug effects. Tumor Cells, Cultured / transplantation

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  • (PMID = 10769638.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] GREECE
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; U3P01618RT / Fluorouracil
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2. Opitz I, Van der Veen H, Witte N, Braumann C, Mueller JM, Jacobi CA: Instillation of taurolidine/heparin after laparotomy reduces intraperitoneal tumour growth in a colon cancer rat model. Eur Surg Res; 2007;39(3):129-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To investigate whether irrigation of the abdominal cavity after laparotomy for caecum resection with taurolidine/heparin or adhesion prophylactic substances reduces intraperitoneal tumour growth or the local recurrence rate in a colon carcinoma rat model.
  • METHODS: 60 BDIX rats underwent caecum resection after intraperitoneal inoculation of 1 x 10(4) colon carcinoma cells (DHD/K12/TRb).
  • E-Cadherin expression in the metastatic tissue of animals treated with taurolidine/heparin was significantly decreased (p = 0.016).
  • [MeSH-major] Adenocarcinoma / drug therapy. Anticoagulants / therapeutic use. Antineoplastic Agents / therapeutic use. Colonic Neoplasms / drug therapy. Heparin / therapeutic use. Neoplasm Recurrence, Local / prevention & control. Taurine / analogs & derivatives. Thiadiazines / therapeutic use
  • [MeSH-minor] Abdominal Neoplasms / drug therapy. Abdominal Neoplasms / pathology. Animals. Immunohistochemistry. Instillation, Drug. Laparotomy. Male. Neoplasm Metastasis / pathology. Neoplasm Metastasis / prevention & control. Rats. Tissue Adhesions / prevention & control

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  • (PMID = 17337889.001).
  • [ISSN] 0014-312X
  • [Journal-full-title] European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes
  • [ISO-abbreviation] Eur Surg Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Anticoagulants; 0 / Antineoplastic Agents; 0 / Thiadiazines; 1EQV5MLY3D / Taurine; 8OBZ1M4V3V / taurolidine; 9005-49-6 / Heparin
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3. Carneiro BA, Kaminer L, Eldibany M, Sreekantaiah C, Kaul K, Locker GY: Oxaliplatin-related acute myelogenous leukemia. Oncologist; 2006 Mar;11(3):261-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 56-year-old woman diagnosed with a poorly differentiated cecal adenocarcinoma with metastases to ovaries, omentum, and sigmoid colon went into remission after 12 cycles of infusional 5-fluorouracil, luecovorin, and oxaliplatin (FOLFOX-4 regimen).
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / pathology. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Humanized. Bevacizumab. Cecal Neoplasms / drug therapy. Cecal Neoplasms / pathology. Chromosome Deletion. Female. Fluorouracil / administration & dosage. Fluorouracil / adverse effects. Humans. Leucovorin / administration & dosage. Leucovorin / adverse effects. Middle Aged. Omentum / pathology. Organoplatinum Compounds / administration & dosage. Organoplatinum Compounds / adverse effects. Ovarian Neoplasms / drug therapy. Ovarian Neoplasms / secondary. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / secondary. Sigmoid Neoplasms / drug therapy. Sigmoid Neoplasms / secondary. Trisomy

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  • (PMID = 16549810.001).
  • [ISSN] 1083-7159
  • [Journal-full-title] The oncologist
  • [ISO-abbreviation] Oncologist
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Organoplatinum Compounds; 2S9ZZM9Q9V / Bevacizumab; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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4. Fuszek P, Horváth HC, Speer G, Papp J, Haller P, Halász J, Járay B, Székely E, Schaff Z, Papp A, Bursics A, Harsányi L, Lukovich P, Kupcsulik P, Hitre E, Lakatos PL: [Change in location of colorectal cancer in Hungarian patients between 1993-2004]. Orv Hetil; 2006 Apr 23;147(16):741-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PATIENTS AND METHODS: Clinical data of 1738 patients diagnosed with colorectal tumors (M/F: 940/798, mean age at diagnosis: 65.2 +/- 12.5 years) between 1st of January 1993 and 31st of December 2004 at the 1st Internal Medicine and 1st Surgery Department of Semmelweis University were enrolled.
  • RESULTS: 1694 (97.5%) of the patients had adenocarcinoma (CRC), 15 anaplastic cancers, 9 carcinoid, 6 planocellular, 5 GIST, 3 leiomyoma and 2-2 melanoma, lymphoma and shigillocellular cancers were diagnosed.
  • 75.7% (943/1246) of the CRCs were diagnosed at locally advanced stage (T3-T4), and 47.7% (521/1093) of CRC patients had lymph node metastasis at the time of diagnosis.
  • Synchronous cancers were detected in 12 patients (age: 68.8 +/- 11.6 years, gender: 11 male/1 female, location: rectum and transverse in 6, rectum and ascending/caecum in 5 patients).
  • Age at diagnosis was not different according to gender (M/F: 64.8 +/- 12.0 years vs. 65.8 +/- 12.9 years), but it was lower in patients with rectal cancer compared to left or right sided cancers (64.1 years vs. left: 66.1 years, right: 66.0 years, p = 0.02).
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Adult. Age Distribution. Aged. Carcinoid Tumor / epidemiology. Carcinoid Tumor / pathology. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / pathology. Female. Gastrointestinal Stromal Tumors / epidemiology. Gastrointestinal Stromal Tumors / pathology. Humans. Hungary / epidemiology. Incidence. Leiomyoma / epidemiology. Leiomyoma / pathology. Lymphoma / epidemiology. Lymphoma / pathology. Male. Melanoma / epidemiology. Melanoma / pathology. Middle Aged. Prevalence. Retrospective Studies. Sex Distribution

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  • (PMID = 16711260.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
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5. Ohnishi T, Kanoh T, Kimura Y, Iwazawa T, Tono T, Nakano Y, Yano K, Monden T: [Successful low-dose TS-1 administration in an elderly colon cancer patient with liver metastasis]. Gan To Kagaku Ryoho; 2007 Apr;34(4):623-5
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  • An 85-year-old man, who had undergone right hemicolectomy and partial hepatectomy for caecum cancer with liver metastasis, was diagnosed with recurrent multiple liver metastasis 10 months after surgery.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antimetabolites, Antineoplastic / administration & dosage. Appendiceal Neoplasms / secondary. Colonic Neoplasms / drug therapy. Liver Neoplasms / secondary. Oxonic Acid / administration & dosage. Tegafur / administration & dosage
  • [MeSH-minor] Aged, 80 and over. Dose-Response Relationship, Drug. Drug Administration Schedule. Drug Combinations. Humans. Male

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  • (PMID = 17431353.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid
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6. Choquet P, Calon A, Breton E, Beck F, Domon-Dell C, Freund JN, Constantinesco A: Multiple-contrast X-ray micro-CT visualization of colon malformations and tumours in situ in living mice. C R Biol; 2007 Nov;330(11):821-7
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  • In vivo imaging could greatly facilitate these trials, but the small size of the animals is a major limitation for the direct visualization of intestinal tissue.
  • Here we report a method of in vivo imaging of the mouse intestine based on X-ray micro-computed tomography using multiple contrast agents.
  • This method was validated in the model of non-cancerous polyp-like heteroplasia that spontaneously develops in the caecum area of Cdx2+/- mutant mice and in the model of colon adenocarcinoma induced by administration of the chemical carcinogen azoxymethane.
  • [MeSH-minor] Animals. Equipment Design. Heterozygote. Homeodomain Proteins / genetics. Intestinal Diseases / radiography. Male. Mice. Mice, Knockout. Transcription Factors / deficiency. Transcription Factors / genetics

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  • (PMID = 17923376.001).
  • [ISSN] 1631-0691
  • [Journal-full-title] Comptes rendus biologies
  • [ISO-abbreviation] C. R. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Cdx2 protein, mouse; 0 / Homeodomain Proteins; 0 / Transcription Factors
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7. Lazar A, Mau-Holzmann UA, Kolb H, Reichenmiller HE, Riess O, Schömig E: Multiple organ failure due to 5-fluorouracil chemotherapy in a patient with a rare dihydropyrimidine dehydrogenase gene variant. Onkologie; 2004 Dec;27(6):559-62
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  • BACKGROUND: Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the metabolism of the chemotherapeutic drug 5-fluorouracil (5-FU).
  • Application of 5-FU is restricted by a narrow therapeutic index because of severe toxicity of WHO grades III-IV.
  • PATIENT AND METHODS: We report a patient with advanced caecum cancer who twice received 950 mg 5-FU and 45 mg folinic acid as adjuvant by bolus injection.
  • [MeSH-major] Cecal Neoplasms / drug therapy. Cecal Neoplasms / enzymology. Dihydropyrimidine Dehydrogenase Deficiency. Fluorouracil / adverse effects. Fluorouracil / therapeutic use. Metabolic Diseases / diagnosis. Metabolic Diseases / enzymology. Multiple Organ Failure / chemically induced
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / enzymology. Adenocarcinoma / genetics. Adult. Antineoplastic Agents / adverse effects. Antineoplastic Agents / therapeutic use. Dihydrouracil Dehydrogenase (NADP) / analysis. Dihydrouracil Dehydrogenase (NADP) / genetics. Genetic Predisposition to Disease / genetics. Humans. Male. Rare Diseases / complications. Rare Diseases / diagnosis. Rare Diseases / enzymology. Rare Diseases / genetics. Treatment Outcome


8. Cavanna L, Bertè R, Bidin L, Civardi G, Anselmi E, Lazzaro A, Moroni CF, Palladino MA, Rodinò C, Vallisa D: Oncologic emergencies secondary to advanced colorectal cancer successfully treated with oxaliplatin/5-fluorouracil/leucovorin: report of three cases. J Chemother; 2005 Jun;17(3):334-8
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  • The first case was a 40-year-old man with severe respiratory insufficiency due to massive carcinomatous lymphangitis; subsequently a cecal adenocarcinoma was diagnosed.
  • Ultrasonically-guided biopsy and colonoscopy showed liver metastases from cecal cancer.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colorectal Neoplasms / complications. Colorectal Neoplasms / drug therapy
  • [MeSH-minor] Acute Disease. Adult. Female. Fluorouracil / administration & dosage. Humans. Intestinal Obstruction / etiology. Leucovorin / administration & dosage. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary. Lymphangitis / etiology. Male. Middle Aged. Organoplatinum Compounds / administration & dosage. Treatment Outcome

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  • (PMID = 16038529.001).
  • [ISSN] 1120-009X
  • [Journal-full-title] Journal of chemotherapy (Florence, Italy)
  • [ISO-abbreviation] J Chemother
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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9. Klein JC, Beems RB, Zwart PE, Hamzink M, Zomer G, van Steeg H, van Kreijl CF: Intestinal toxicity and carcinogenic potential of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in DNA repair deficient XPA-/- mice. Carcinogenesis; 2001 Apr;22(4):619-26
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  • The results show that PhIP is extremely toxic to XPA(-/-) mice, even at doses 10-fold lower than tolerated by wild-type C57BL/6 mice.
  • Intestinal abnormalities like distended and overfilled ileum and caecum, together with clear signs of starvation, suggests that the small intestines were the primary target tissue for the severe toxic effects.
  • [MeSH-major] Carcinogens / toxicity. DNA Repair / genetics. Imidazoles / toxicity. Intestines / drug effects. Mutagens / toxicity
  • [MeSH-minor] Adenocarcinoma / chemically induced. Adenoma / chemically induced. Animals. Body Weight / drug effects. DNA Mutational Analysis. Dose-Response Relationship, Drug. Female. Genes, Reporter. Genotype. Ileum / drug effects. Intestinal Neoplasms / chemically induced. Intestine, Small / drug effects. Lac Operon. Lymphoma / chemically induced. Male. Mice. Mice, Inbred C57BL. Mice, Knockout. Sex Factors. Time Factors. Transcription, Genetic

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  • (PMID = 11285198.001).
  • [ISSN] 0143-3334
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 1R01 CA75653
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Imidazoles; 0 / Mutagens; 909C6UN66T / 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
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10. Abela JE, Wright DM, Hennessy A, Roberts F, Anderson JR: Chemotherapy induced carcinoma-adenoma regression in the caecum. J Clin Pathol; 2009 Mar;62(3):282-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chemotherapy induced carcinoma-adenoma regression in the caecum.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenoma / pathology. Cecal Neoplasms / drug therapy. Neoplasms, Multiple Primary / drug therapy
  • [MeSH-minor] Aged. Chemotherapy, Adjuvant. Esophagogastric Junction. Humans. Male. Neoadjuvant Therapy. Remission Induction. Stomach Neoplasms / drug therapy. Stomach Neoplasms / pathology. Stomach Neoplasms / surgery

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  • (PMID = 19251957.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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11. Chodos MD, Johnson CA: Hematogenous infection of a total knee arthroplasty with Klebsiella pneumoniae in association with occult adenocarcinoma of the cecum. J Arthroplasty; 2009 Jan;24(1):158.e9-158.e13
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  • [Title] Hematogenous infection of a total knee arthroplasty with Klebsiella pneumoniae in association with occult adenocarcinoma of the cecum.
  • This is the first reported case of K pneumoniae pyogenic arthritis with a coexisting occult colonic adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Colonic Neoplasms / diagnosis. Klebsiella Infections / diagnosis. Klebsiella pneumoniae. Knee Prosthesis / microbiology. Neoplasms, Unknown Primary / diagnosis. Prosthesis-Related Infections / diagnosis
  • [MeSH-minor] Anti-Bacterial Agents / therapeutic use. Arthritis, Infectious / complications. Arthritis, Infectious / diagnosis. Arthritis, Infectious / drug therapy. Arthroplasty, Replacement, Knee. Combined Modality Therapy. Debridement. Humans. Male. Middle Aged

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  • (PMID = 18534412.001).
  • [ISSN] 1532-8406
  • [Journal-full-title] The Journal of arthroplasty
  • [ISO-abbreviation] J Arthroplasty
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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