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1. Fernández Rivera C, Alonso Hernández Á, Mosquera Reboredo J, Rodríguez Gómez I: Association of bladder adenocarcinoma and BK virus infection in a pancreatico-renal transplant recipient. NDT Plus; 2010 Jun;3(3):300-302
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  • [Title] Association of bladder adenocarcinoma and BK virus infection in a pancreatico-renal transplant recipient.
  • We report a case of urinary bladder adenocarcinoma in a pancreatico-renal transplant recipient which was diagnosed 2 years after BKV infection.

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  • [Cites] Pediatr Transplant. 2008 Aug;12(5):600-5 [18652620.001]
  • [Cites] Oncogene. 2006 May 4;25(19):2727-35 [16547506.001]
  • [Cites] Transplantation. 2008 Apr 15;85(7 Suppl):S42-8 [18401263.001]
  • [Cites] NDT Plus. 2009 Jun;2(3):246-9 [25984002.001]
  • [Cites] Oncogene. 2003 Aug 11;22(33):5192-200 [12910256.001]
  • [Cites] Virus Res. 1989 Apr;12(4):315-30 [2543158.001]
  • [Cites] J Am Soc Nephrol. 2004 Jun;15(6):1582-8 [15153569.001]
  • [Cites] J Infect Dis. 2005 Oct 15;192(8):1349-54 [16170751.001]
  • [Cites] Transplantation. 2005 May 27;79(10):1277-86 [15912088.001]
  • [Cites] Transplantation. 2009 Mar 15;87(5):621-30 [19295303.001]
  • [Cites] Transplantation. 2008 Mar 27;85(6):850-4 [18360267.001]
  • [Cites] Transplantation. 2002 Jun 27;73(12):1933-6 [12131691.001]
  • (PMID = 28657060.001).
  • [ISSN] 1753-0784
  • [Journal-full-title] NDT plus
  • [ISO-abbreviation] NDT Plus
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; BK virus / kidney transplantation / renal transplantation / urinary bladder neoplasms
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2. Vignoli M, Rossi F, Chierici C, Terragni R, De Lorenzi D, Stanga M, Olivero D: Needle tract implantation after fine needle aspiration biopsy (FNAB) of transitional cell carcinoma of the urinary bladder and adenocarcinoma of the lung. Schweiz Arch Tierheilkd; 2007 Jul;149(7):314-8
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  • [Title] Needle tract implantation after fine needle aspiration biopsy (FNAB) of transitional cell carcinoma of the urinary bladder and adenocarcinoma of the lung.
  • Primary tumors were two transitional cell carcinomas of the urinary bladder (2 dogs) and one pulmonary adenocarcinoma (1 cat).
  • To our knowledge, the seeding of pulmonary adenocarcinoma cells after FNAB on the thoracic wall has never been reported in veterinary medicine.
  • [MeSH-major] Adenocarcinoma / veterinary. Carcinoma, Transitional Cell / veterinary. Cat Diseases / pathology. Dog Diseases / pathology. Lung Neoplasms / veterinary. Neoplasm Seeding. Urinary Bladder Neoplasms / veterinary
  • [MeSH-minor] Abdominal Wall / pathology. Animals. Biopsy, Fine-Needle / adverse effects. Biopsy, Fine-Needle / veterinary. Cats. Diagnosis, Differential. Dogs. Fatal Outcome. Female. Male

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  • (PMID = 17702491.001).
  • [ISSN] 0036-7281
  • [Journal-full-title] Schweizer Archiv für Tierheilkunde
  • [ISO-abbreviation] Schweiz. Arch. Tierheilkd.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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3. Singh I, Pachisia SS, Kumar S, Arora VK, Kumar P: Emphysematous pyelonephritis: a consequence of adenocarcinoma of urinary bladder in a nondiabetic patient. J Postgrad Med; 2005 Oct-Dec;51(4):324-5
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  • [Title] Emphysematous pyelonephritis: a consequence of adenocarcinoma of urinary bladder in a nondiabetic patient.
  • Emphysematous pyelonephritis (EP) is a life threatening condition of acute necrotising renal parenchymal infection that encompasses a much wider spectrum of complicated urinary tract infections such as renal abscesses, emphysematous pyelitis, pyelonephritis, acute renal papillary necrosis, and sepsis.
  • We report an unusual case of adenocarcinoma bladder in a middle aged nondiabetic patient, presenting with EP.
  • Emphysematous pyelonephritis was the initial symptom in this case with an underlying carcinoma of the bladder.
  • The role of imaging is prime in management of such cases, if an early diagnosis is to be made and a potentially devastating outcome is to be avoided.
  • [MeSH-major] Adenocarcinoma / complications. Emphysema / complications. Pyelonephritis / complications. Urinary Bladder Neoplasms / complications

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  • (PMID = 16388179.001).
  • [ISSN] 0022-3859
  • [Journal-full-title] Journal of postgraduate medicine
  • [ISO-abbreviation] J Postgrad Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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4. Suh N, Yang XJ, Tretiakova MS, Humphrey PA, Wang HL: Value of CDX2, villin, and alpha-methylacyl coenzyme A racemase immunostains in the distinction between primary adenocarcinoma of the bladder and secondary colorectal adenocarcinoma. Mod Pathol; 2005 Sep;18(9):1217-22
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  • [Title] Value of CDX2, villin, and alpha-methylacyl coenzyme A racemase immunostains in the distinction between primary adenocarcinoma of the bladder and secondary colorectal adenocarcinoma.
  • Primary adenocarcinoma of the urinary bladder is an uncommon neoplasm that can be indistinguishable morphologically from colorectal adenocarcinoma secondarily involving the bladder by direct extension or metastasis.
  • In the current study, 17 enteric-type primary adenocarcinomas of the bladder were immunohistochemically examined for the expression of CDX2, villin and alpha-methylacyl coenzyme A racemase (AMACR), immunomarkers preferentially expressed in colorectal adenocarcinoma.
  • For comparison, 17 secondary colorectal adenocarcinomas involving the bladder, 23 primary colorectal adenocarcinomas and 14 conventional urothelial carcinomas were similarly studied.
  • The expression of these two immunomarkers was less frequent in primary bladder adenocarcinomas, observed in eight (47%) and 11 (65%) cases, respectively (P<0.0001 and P=0.0019, respectively).
  • The frequency of positive AMACR immunostaining was similar between these two types of tumors, detected in 28 (70%) colorectal adenocarcinomas and 11 (65%) primary bladder adenocarcinomas (P=0.694).
  • These results demonstrate that CDX2 and villin are of diagnostic value in aiding in the distinction between primary adenocarcinoma of the bladder and secondary colorectal carcinoma.
  • Lack of CDX2 and villin signals points strongly to a bladder primary.
  • [MeSH-major] Adenocarcinoma / secondary. Biomarkers, Tumor / analysis. Carcinoma, Transitional Cell / pathology. Colorectal Neoplasms / secondary. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Homeodomain Proteins / metabolism. Humans. Immunohistochemistry. Microfilament Proteins / metabolism. Racemases and Epimerases / metabolism

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  • (PMID = 15803184.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / Microfilament Proteins; 0 / villin; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
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5. Zaghloul MS, El Baradie M, Nouh, Abdel-Fatah S, Taher A, Shalaan M: Prognostic index for primary adenocarcinoma of the urinary bladder. Gulf J Oncolog; 2007 Jul;(2):47-54
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  • [Title] Prognostic index for primary adenocarcinoma of the urinary bladder.
  • AIM: To determine the working independent prognostic factors and the prognostic index of adenocarcinoma of the urinary bladder.
  • PATIENTS AND METHODS: Two hundred and sixteen patients having adenocarcinoma of the urinary bladder were treated with radical cystectomy and pelvic lymphadenectomy with (82 patients) or without (134) postoperative radiotherapy.
  • CONCLUSIONS: The identified prognostic indices with their prognostic group could be used not only as a predictor of disease-free survival but also as a good predictor for the need to add adjuvant therapy in adenocarcinoma of the urinary bladder.
  • [MeSH-major] Adenocarcinoma / diagnosis. Urinary Bladder Neoplasms / diagnosis

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  • (PMID = 20084724.001).
  • [ISSN] 2078-2101
  • [Journal-full-title] The Gulf journal of oncology
  • [ISO-abbreviation] Gulf J Oncolog
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Kuwait
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6. Kobayashi S, Tsukamoto T, Tohsaka A, Tohma T: [A case of adenocarcinoma of the urinary bladder arising 45 years after ileal replacement of ureter for tuberculous ureteral stricture]. Hinyokika Kiyo; 2008 Mar;54(3):235-8
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  • [Title] [A case of adenocarcinoma of the urinary bladder arising 45 years after ileal replacement of ureter for tuberculous ureteral stricture].
  • We report a case of adenocarcinoma arising in the urinary bladder 45 years after ileal replacement of ureter for tuberculous ureteral stricture.
  • Cystoscopic examination demonstrated a broadbased non-papillary tumor on the left posterior wall of the bladder and a papillary tumor at the anastomotic site between the bladder and ileal segment.
  • The histopathological examination demonstrated well differentiated adenocarcinoma of the bladder and ileal ureter.
  • Intestinal metaplasia widely infiltrated into the bladder epithelium around the anastomotic site.
  • [MeSH-major] Adenocarcinoma / etiology. Tuberculosis, Urogenital / surgery. Ureteral Obstruction / surgery. Urinary Bladder Neoplasms / etiology. Urinary Diversion

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  • (PMID = 18411782.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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7. Martínez-Rodríguez M, Ramos D, Soriano P, Subramaniam M, Navarro S, Llombart-Bosch A: Poorly differentiated adenocarcinomas of prostate versus high-grade urothelial carcinoma of the bladder: a diagnostic dilemma with immunohistochemical evaluation of 2 cases. Int J Surg Pathol; 2007 Apr;15(2):213-8
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  • [Title] Poorly differentiated adenocarcinomas of prostate versus high-grade urothelial carcinoma of the bladder: a diagnostic dilemma with immunohistochemical evaluation of 2 cases.
  • The differential diagnosis between carcinoma of the urinary bladder and adenocarcinoma of the prostate can be difficult, especially in the poorly differentiated forms infiltrating the neighboring organs.
  • The first is an infiltration of the bladder by a poorly differentiated adenocarcinoma of the prostate, which was clinically suspected as a papillary urothelial neoplasm.
  • The second is a collision tumor composed of prostatic adenocarcinoma and urothelial carcinoma observed on a core needle biopsy of the prostate.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Transitional Cell / pathology. Prostatic Neoplasms / pathology. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Male. Neoplasms, Multiple Primary. Prostate-Specific Antigen / metabolism. Racemases and Epimerases / metabolism

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  • (PMID = 17478786.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.21.77 / Prostate-Specific Antigen; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
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8. Morton MJ, Zhang S, Lopez-Beltran A, MacLennan GT, Eble JN, Montironi R, Sung MT, Tan PH, Zheng S, Zhou H, Cheng L: Telomere shortening and chromosomal abnormalities in intestinal metaplasia of the urinary bladder. Clin Cancer Res; 2007 Oct 15;13(20):6232-6
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  • [Title] Telomere shortening and chromosomal abnormalities in intestinal metaplasia of the urinary bladder.
  • PURPOSE: Although intestinal metaplasia is often found in association with adenocarcinoma of the urinary bladder, it is unclear whether intestinal metaplasia of the bladder is a premalignant lesion.
  • We used quantitative fluorescent in situ hybridization (FISH) to measure telomere length and UroVysion FISH to detect cytogenetic abnormalities in urinary bladder specimens with intestinal metaplasia.
  • EXPERIMENTAL DESIGN: Paraffin-embedded tissue blocks from 34 patients with intestinal metaplasia of the urinary bladder were evaluated.
  • CONCLUSIONS: Our findings indicate that intestinal metaplasia in the urinary bladder is associated with significant telomere shortening relative to telomere length in adjacent normal urothelial cells.
  • Our findings support the hypothesis that intestinal metaplasia of the urinary bladder is a precursor lesion to and could be a marker in the development of adenocarcinoma of the urinary bladder.
  • [MeSH-major] Chromosome Aberrations. Intestines / pathology. Metaplasia / pathology. Telomere / ultrastructure. Urinary Bladder Neoplasms / genetics. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / etiology. Adenocarcinoma / genetics. Chromosomes / ultrastructure. Cystitis / complications. Cytogenetics. Humans. Immunohistochemistry / methods. In Situ Hybridization, Fluorescence. Precancerous Conditions / genetics

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  • (PMID = 17947491.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Jungwirth N, Haeberle L, Schrott KM, Wullich B, Krause FS: Serotonin used as prognostic marker of urological tumors. World J Urol; 2008 Oct;26(5):499-504
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  • INTRODUCTION: In regard to therapy and prognosis of urological tumors, specific tumor markers are lacking especially in renal and urinary bladder carcinoma.
  • Our study examines the relevance of serum serotonin levels to urinary bladder, prostate, renal, and testicular carcinoma when it comes to prognosis and occurrence of these oncological conditions.
  • MATERIALS AND METHODS: Serotonin levels were obtained in 109 patients presenting with urothelial carcinoma to the urinary bladder, adenocarcinoma of the prostate and renal cell carcinoma, as well as presenting with seminomatous and non-seminomatous testicular tumors.
  • Otherwise there was no correlation observed with stage and grade as well as with common tumor markers (AFP/betaHCG).
  • CONCLUSION: Serotonin levels are suitable for prognostic evaluation of urothelial carcinoma in the urinary bladder, adenocarcinoma of the prostate, and renal cell carcinoma, especially taking into account the lab cost of 25<euro> per test.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Renal Cell / blood. Female. Humans. Male. Middle Aged. Prognosis. Prostatic Neoplasms / blood. Testicular Neoplasms / blood. Urinary Bladder Neoplasms / blood. Young Adult

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  • (PMID = 18581119.001).
  • [ISSN] 0724-4983
  • [Journal-full-title] World journal of urology
  • [ISO-abbreviation] World J Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 333DO1RDJY / Serotonin
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10. Gardner JM, Khurana H, Leach FS, Ayala AG, Zhai J, Ro JY: Adenocarcinoma in ectopic prostatic tissue at dome of bladder: a case report of a patient with urothelial carcinoma of the bladder and adenocarcinoma of the prostate. Arch Pathol Lab Med; 2010 Sep;134(9):1271-5
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  • [Title] Adenocarcinoma in ectopic prostatic tissue at dome of bladder: a case report of a patient with urothelial carcinoma of the bladder and adenocarcinoma of the prostate.
  • We report a case of ectopic prostate tissue with an associated prostatic adenocarcinoma occurring in the dome of the urinary bladder.
  • A 62-year-old man presented with a 4-month history of persistent microscopic hematuria following a urinary tract infection.
  • Cystoscopic examination revealed a sessile lesion of the anterior bladder neck and multiple smaller papillary lesions throughout the bladder.
  • Following a transurethral resection of the bladder tumor with a diagnosis of muscle-invasive transitional cell carcinoma grade 3, a radical cystoprostatectomy was performed.
  • The diagnosis of transitional cell carcinoma was confirmed, but in addition, a different lesion was also incidentally found in the dome of the bladder.
  • This incidental lesion showed a prostatic adenocarcinoma arising from ectopic prostatic tissue within the bladder submucosa.
  • The prostate also showed prostatic adenocarcinoma, but this was minimal, low grade, and confined to the prostate gland, and thus it was felt to be unlikely to have metastasized to the bladder dome.
  • Adenocarcinoma arising in ectopic prostatic tissue is a rare finding and to our knowledge only 1 case has been previously described, occurring in the soft tissue adjacent to the prostate.
  • We report the first case of adenocarcinoma arising in ectopic prostatic tissue within the bladder.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Transitional Cell / pathology. Choristoma / pathology. Neoplasms, Multiple Primary / pathology. Prostate / pathology. Prostatic Neoplasms / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 20807045.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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11. Raspollini MR, Nesi G, Baroni G, Girardi LR, Taddei GL: Immunohistochemistry in the differential diagnosis between primary and secondary intestinal adenocarcinoma of the urinary bladder. Appl Immunohistochem Mol Morphol; 2005 Dec;13(4):358-62
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  • [Title] Immunohistochemistry in the differential diagnosis between primary and secondary intestinal adenocarcinoma of the urinary bladder.
  • Distinguishing between primary adenocarcinomas and secondary colonic adenocarcinomas of the urinary bladder is often difficult because they appear morphologically similar but invariably require different treatment strategies.
  • The aim of the study was to define the utility of a limited immunohistochemical panel consisting of CDX-2, cytokeratins 7 (CK7) and 20 (CK20), and carcinoembryonic antigen (CEA) in differentiating primary from secondary bladder adenocarcinomas.
  • Formalin-fixed, paraffin-embedded tissues from 8 primary bladder adenocarcinomas and 23 colorectal adenocarcinomas involving the bladder were included in the study.
  • The majority (87.5%) of primary bladder adenocarcinomas were CDX-2 negative, and only one case of primary bladder adenocarcinoma was positive, while CDX-2 was strongly expressed in the nucleus of all cases of secondary (colonic) bladder tumor (P < 0.0005).
  • Five cases (62.5%) of primary bladder adenocarcinoma and one case (4.3%) of secondary bladder tumor showed positive staining for CK7 (P = 0.002), whereas CK20 showed positive staining in five cases (62.5%) of primary bladder adenocarcinoma and in all the secondary bladder tumors (P = 0.012).
  • All 23 secondary bladder tumors and 7 primary bladder adenocarcinomas (87.5%) expressed CEA (P = 0.25).
  • These data demonstrate that a restricted immunohistochemical panel consisting of CDX-2, CK7, CK20, and CEA may be of use in differentiating primary bladder adenocarcinoma from secondary adenocarcinoma of colorectal origin.

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  • (PMID = 16280666.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen; 0 / Homeodomain Proteins; 0 / Intermediate Filament Proteins; 0 / KRT20 protein, human; 0 / KRT7 protein, human; 0 / Keratin-20; 0 / Keratin-7; 0 / Trans-Activators; 156560-97-3 / Cdx-2-3 protein; 68238-35-7 / Keratins
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12. Lane Z, Hansel DE, Epstein JI: Immunohistochemical expression of prostatic antigens in adenocarcinoma and villous adenoma of the urinary bladder. Am J Surg Pathol; 2008 Sep;32(9):1322-6
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  • [Title] Immunohistochemical expression of prostatic antigens in adenocarcinoma and villous adenoma of the urinary bladder.
  • Adenocarcinomas of the bladder are rare, with the diagnosis dependent on exclusion of secondary involvement by direct extension or metastatic spread from other sites.
  • The recent description of an unusual form of urothelial-type mucinous prostatic adenocarcinoma raises a novel differential diagnosis between adenocarcinomas of the prostate and bladder, and investigation into the utility of classic prostatic immunohistochemical antigens in bladder adenocarcinoma is warranted.
  • We identified 37 primary infiltrating adenocarcinomas of the bladder, which included signet ring cell carcinomas (n=11), urachal adenocarcinomas (n=5), and enteric adenocarcinoma (n=21).
  • Also included for comparison were 3 cases, each of bladder villous adenomas and bladder adenocarcinoma in situ.
  • In contrast, a minority of bladder adenocarcinomas was labeled with the prostate antigens P501S and PSMA.
  • P501S showed moderate diffuse cytoplasmic staining in 4/37 cases (11%), including 3 enteric-type adenocarcinomas and 1 mucinous adenocarcinoma.
  • Additionally, 1 case of adenocarcinoma in situ demonstrated diffuse cytoplasmic staining for P501S.
  • The granular perinuclear staining pattern of P501S typically seen in prostatic adenocarcinoma was absent in all cases of bladder adenocarcinoma.
  • PSMA showed diffuse cytoplasmic staining in 4/37 (11%) infiltrating adenocarcinomas (including 1 signet ring carcinoma and 3 enteric-type adenocarcinomas), and in 1 case of adenocarcinoma in situ.
  • Membranous PSMA staining was evident in an additional 3 tumors, 1 urachal mucinous adenocarcinoma, 1 nonurachal mucinous and signet ring cell adenocarcinoma, and 1 nonurachal villous adenoma.
  • In conclusion, although all cases of bladder adenocarcinoma examined were negative for PSA and PSAP, the surprising finding that a subset of invasive and in situ adenocarcinomas of the bladder demonstrated immunoreactivity for P501S and PSMA should warrant caution when using these markers in differentiating prostatic from bladder adenocarcinomas.
  • The lack of granular perinuclear staining for P501S and the absence of membranous PSMA staining both favor a bladder adenocarcinoma, although rare cases of villous adenoma and adenocarcinoma did show PSMA membranous staining indistinguishable from that seen in prostate cancer.
  • Although the novel antigens P501S and PSMA are fairly specific and more sensitive in the differential diagnosis of prostate and urothelial carcinoma, care must be taken when adenocarcinomas of the bladder are considered within this differential diagnosis.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma, Villous / metabolism. Antigens, Neoplasm / biosynthesis. Urinary Bladder Neoplasms / metabolism
  • [MeSH-minor] Acid Phosphatase. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Membrane Proteins / biosynthesis. Prostate-Specific Antigen / biosynthesis. Prostatic Neoplasms / metabolism. Prostatic Neoplasms / pathology. Protein Tyrosine Phosphatases / biosynthesis. Tissue Array Analysis

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  • (PMID = 18670358.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Membrane Proteins; 0 / prostein; EC 3.1.3.2 / Acid Phosphatase; EC 3.1.3.2 / prostatic acid phosphatase; EC 3.1.3.48 / Protein Tyrosine Phosphatases; EC 3.4.21.77 / Prostate-Specific Antigen
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13. Romero Otero J, Duarte Ojeda JM, Cruceyra Betriu G, Pérez-Martín ME, Sanchís Bonet A, Tejido Sánchez A, Leiva Galvis O: [Primary adenocarcinoma of the urinary bladder: our experience]. Actas Urol Esp; 2005 Mar;29(3):257-60

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  • [Title] [Primary adenocarcinoma of the urinary bladder: our experience].
  • [Transliterated title] Adenocarcinoma vesical primario: nuestra experiencia.
  • Adenocarcinoma of the bladder is an uncommon neoplasm.
  • Generally it grows to the density of the wall, so its clinical appearence is delayed, with the subsequent delayed diagnosis and although an agressive treatment is performed, it frequently has a very bad prognosis.
  • Since there are very few publications of this kind of neoplasm in the literature the lines of actuation in this pathology are not well established.
  • We report the eleven cases of adenocarcinoma neoplasm of the bladder treated in our centre and review the literature.
  • [MeSH-major] Adenocarcinoma
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Retrospective Studies. Urinary Bladder Neoplasms / diagnosis. Urinary Bladder Neoplasms / therapy

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  • (PMID = 15945250.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 19
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14. Miura K, Kobayashi T, Funayama Y, Fukushima K, Ogawa H, Oyama A, Itoh A, Moriya T, Yamada T, Okumoto T, Shibata C, Sasaki I: Giant T4 rectal carcinoma mimicking urinary bladder adenocarcinoma accurately diagnosed by immunohistochemistry and successfully treated with total pelvic exenteration: report of a case. Surg Today; 2008;38(3):261-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant T4 rectal carcinoma mimicking urinary bladder adenocarcinoma accurately diagnosed by immunohistochemistry and successfully treated with total pelvic exenteration: report of a case.
  • A 54-year-old man, with the chief complaints of hematuria, pollakisuria, and pneumaturia, was referred to our hospital, with a diagnosis of giant urinary bladder adenocarcinoma with massive invasion to the rectum.
  • On the basis of the radiological diagnosis and findings of hematoxylin and eosin (H&E) of biopsy specimens, it was difficult to conclude whether the adenocarcinoma originated in the bladder or in the rectum.
  • The immunohistochemical staining of the biopsy specimens showed cytokeratin 7 (CK7)(-) and CK20(+), which supported the notion that the adenocarcinoma possibly originated from the rectum.
  • Although the prognosis of T4 bladder adenocarcinomas has been reported to be quite poor in comparison with that of transitional cell carcinomas, the postoperative prognosis of T4 rectal adenocarcinomas has been reported to be more favorable and such tumors are recommended to be surgically resected.
  • Although the resected tumor measured 12 cm in diameter with n1 metastasis, the radial margin was cancer-negative, and the tumor was curatively resected.
  • The immunohistochemical diagnosis of the resected tumor showed carcinoembryonic antigen(+), CK7(-), CK20(+), thrombomodulin(-), and uroplakin(-), which supported the rectal origin.
  • At present the patient is undergoing postoperative adjuvant chemotherapy for rectal cancer.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Pelvic Exenteration. Rectal Neoplasms / diagnosis. Rectal Neoplasms / surgery. Urinary Bladder Neoplasms / diagnosis

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  • (PMID = 18307003.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Keratin-20; 0 / Keratin-7
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15. Zaghloul MS, Nouh A, Nazmy M, Ramzy S, Zaghloul AS, Sedira MA, Khalil E: Long-term results of primary adenocarcinoma of the urinary bladder: a report on 192 patients. Urol Oncol; 2006 Jan-Feb;24(1):13-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term results of primary adenocarcinoma of the urinary bladder: a report on 192 patients.
  • OBJECTIVES: To evaluate the clinical presentation and treatment end results of primary adenocarcinoma of the urinary bladder, and to determine the significant independent prognostic factors that determine this outcome.
  • PATIENTS AND METHODS: Of 3659 patients who underwent cystectomy, 192 had adenocarcinoma of the urinary bladder, with a relative frequency of 5.2%.
  • Mucinous adenocarcinoma was reported in 28 patients (14.6%), papillary in 20 (10.4%), signet ring in 14 (7.3%), while not otherwise specified was reported in 130 (67.7%) in the cystectomy specimens.
  • RESULTS: Mucinous and signet-ring histologic subtypes showed increased frequency of high stages and high grades, and more nodal involvement than the papillary and not otherwise specified.
  • The 5-year disease-free survival rate was 46 +/- 4% for all patients with adenocarcinoma.
  • The disease-free survival independent prognostic variables were tumor stage, postoperative radiotherapy, nodal involvement, and adenocarcinoma subclassification.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Adenocarcinoma / surgery. Cystectomy. Urinary Bladder Neoplasms / radiotherapy. Urinary Bladder Neoplasms / surgery

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  • (PMID = 16414487.001).
  • [ISSN] 1078-1439
  • [Journal-full-title] Urologic oncology
  • [ISO-abbreviation] Urol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Sugimori K, Kobayashi K, Hayashi M, Sakai N, Sasaki M, Koshino Y: Leptomeningeal carcinomatosis from urinary bladder adenocarcinoma: a clinicopathological case study. Neuropathology; 2005 Mar;25(1):89-94
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  • [Title] Leptomeningeal carcinomatosis from urinary bladder adenocarcinoma: a clinicopathological case study.
  • We report a 73-year-old male patient with leptomeningeal metastasis from urinary bladder adenocarcinoma.
  • Meningeal carcinomatosis was detected 5 days before his death, but the primary site of the malignant tumor could not be determined.
  • Necropsy revealed leptomeningeal infiltration of many adenocarcinoma cells that covered the cerebrum.
  • Meningeal carcinomatosis from urinary bladder adenocarcinoma is extremely rare and up-regulation of the adhesion molecules in the meningeal adenocarcinoma was confirmed.
  • [MeSH-major] Adenocarcinoma / secondary. Meningeal Neoplasms / secondary. Urinary Bladder Neoplasms / pathology

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  • (PMID = 15822823.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Vascular Cell Adhesion Molecule-1; 68238-35-7 / Keratins
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17. Raspollini MR, Comin CE, Crisci A, Chilosi M: The use of placental S100 (S100P), GATA3 and napsin A in the differential diagnosis of primary adenocarcinoma of the bladder and bladder metastasis from adenocarcinoma of the lung. Pathologica; 2010 Feb;102(1):33-5
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  • [Title] The use of placental S100 (S100P), GATA3 and napsin A in the differential diagnosis of primary adenocarcinoma of the bladder and bladder metastasis from adenocarcinoma of the lung.
  • Primary bladder adenocarcinoma accounts for 0.5-2% of all malignant bladder tumours.
  • Literature data indicate the bladder as the second most common site of metastatic genitourinary tumours, with the kidney as the most frequent location.
  • Secondary tumours of the bladder account for about 2.3% of all bladder malignancies encountered in surgical specimens.
  • Herein, we describe an adenocarcinoma deeply infiltrating the bladder wall, with no morphologic features of transitional cell carcinoma, in a patient with a previous diagnosis of primary lung adenocarcinoma, mixed subtype.
  • In this case, the use of a limited immunohistochemical panel including napsin A, a recently described highly sensitive marker for lung adenocarcinoma, GATA3 and S100P, two novel markers of urothelial differentiation, was of crucial importance in differentiating between lung adenocarcinoma metastatic to the bladder and primary bladder adenocarcinoma.
  • [MeSH-major] Adenocarcinoma. Aspartic Acid Endopeptidases / metabolism. Biomarkers, Tumor / metabolism. GATA3 Transcription Factor / metabolism. Lung Neoplasms. S100 Proteins / metabolism. Urinary Bladder Neoplasms

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  • (PMID = 20731252.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / GATA3 Transcription Factor; 0 / GATA3 protein, human; 0 / S100 Proteins; EC 3.4.23.- / Aspartic Acid Endopeptidases; EC 3.4.23.- / NAPSA protein, human
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18. Sun K, Huan Y, Unger PD: Clear cell adenocarcinoma of urinary bladder and urethra: another urinary tract lesion immunoreactive for P504S. Arch Pathol Lab Med; 2008 Sep;132(9):1417-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clear cell adenocarcinoma of urinary bladder and urethra: another urinary tract lesion immunoreactive for P504S.
  • CONTEXT: Clear cell carcinoma of the urinary bladder/ urethra is a rare tumor histologically resembling the neoplasms in the female genital tract.
  • Adequate characterization of this tumor has been hampered by its rarity. alpha-Methylacyl-CoA racemase (AMACR)/P504S has been reported to be positive in prostatic adenocarcinoma, papillary renal cell carcinoma, and gastrointestinal neoplasmas; however, it has never been studied in clear cell carcinoma of the lower urinary tract.
  • OBJECTIVE: To investigate the immunohistochemical staining profile in 4 primary clear cell carcinomas of the urinary tract, including P504S, which has not been previously evaluated in these tumors.
  • DESIGN: Four cases of clear cell adenocarcinoma were retrieved from our archives: 2 cases from the urinary bladder (one each from a man and a woman) and 2 cases from the urethra (both from women, 1 in a diverticulum).
  • This staining profile may suggest a nonurothelial origin for these tumors, may serve as a useful tool in the differential diagnosis of this tumor, and may reflect its etiology.
  • Because similar expression of P504S is also seen in nephrogenic adenomas, this marker should not be used to differentiate nephrogenic adenomas from clear cell adenocarcinomas.
  • [MeSH-major] Adenocarcinoma, Clear Cell / metabolism. Biomarkers, Tumor / analysis. Racemases and Epimerases / biosynthesis. Urethral Neoplasms / metabolism. Urinary Bladder Neoplasms / metabolism

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  • (PMID = 18788852.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-125 Antigen; 0 / CKAP4 protein, human; 0 / Keratin-20; 0 / Keratin-7; 0 / Membrane Proteins; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
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19. Neeli S, Prabha V, Alur S, Malur P: Penile metastasis from primay mucinous adenocarcinoma of bladder. Indian J Urol; 2007 Jul;23(3):314-6

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  • [Title] Penile metastasis from primay mucinous adenocarcinoma of bladder.
  • Primary adenocarcinoma of the urinary bladder is not common.
  • Though penile metastases from transitional cell carcinoma are reported, such metastases from adenocarcinoma of urinary bladder is unknown.
  • We report a 55-year-old male having penile metastasis from primary mucinous adenocarcinoma of bladder.

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  • [Cites] Br J Urol. 1998 Aug;82(2):206-12 [9722755.001]
  • [Cites] Cancer. 1991 Apr 15;67(8):2165-72 [1706216.001]
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  • (PMID = 19718338.001).
  • [ISSN] 0970-1591
  • [Journal-full-title] Indian journal of urology : IJU : journal of the Urological Society of India
  • [ISO-abbreviation] Indian J Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2721614
  • [Keywords] NOTNLM ; Adenocarcinoma / penile metastasis / urinary bladder neoplasm
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20. Khan MH, Dooldeniya MD, Shaikh NA: Urothelial adenocarcinoma in a non-functioning bladder. Scand J Urol Nephrol; 2007;41(2):168-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Urothelial adenocarcinoma in a non-functioning bladder.
  • Urinary diversion is a common final outcome in patients with refractory long-term incontinence.
  • It is even more common in young patients with neurogenic bladders and in such cases the bladder is disconnected and left in situ.
  • We present a unique case of adenocarcinoma of the bladder which occurred 31 years following such a diversion procedure.
  • [MeSH-major] Adenocarcinoma / complications. Adenocarcinoma / diagnosis. Postoperative Complications / diagnosis. Urinary Bladder Neoplasms / complications. Urinary Bladder Neoplasms / diagnosis. Urinary Diversion

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  • (PMID = 17454958.001).
  • [ISSN] 0036-5599
  • [Journal-full-title] Scandinavian journal of urology and nephrology
  • [ISO-abbreviation] Scand. J. Urol. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
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21. Lauretti S, Mosca A, D'Alfonso V, Donadio D, Brisciani A: Primitive mucinous adenocarcinoma of the bladder. A case report. Arch Ital Urol Androl; 2006 Mar;78(1):32-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primitive mucinous adenocarcinoma of the bladder. A case report.
  • Primary mucing-producing adenocarcinoma of the bladder is a rare, highly malignant tumor.
  • It is classified as the third most frequent histologic type of bladder carcinoma characterized by a poor response to radiotherapy and/or chemotherapy.
  • Only surgery seems to offer the best approach to this unusual cancer The authors report the pathological findings and the clinical course of a 45-years old man with a primary mucin-secreting adenocarcinoma of the bladder.

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  • (PMID = 16752888.001).
  • [ISSN] 1124-3562
  • [Journal-full-title] Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica
  • [ISO-abbreviation] Arch Ital Urol Androl
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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22. Herawi M, Drew PA, Pan CC, Epstein JI: Clear cell adenocarcinoma of the bladder and urethra: cases diffusely mimicking nephrogenic adenoma. Hum Pathol; 2010 Apr;41(4):594-601
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clear cell adenocarcinoma of the bladder and urethra: cases diffusely mimicking nephrogenic adenoma.
  • Although clear cell adenocarcinoma have been described focally mimicking nephrogenic adenoma, we have identified a subset of clear cell adenocarcinoma that diffusely resembles nephrogenic adenoma (nephrogenic adenoma-like clear cell adenocarcinoma).
  • Twelve classic clear cell adenocarcinomas of the bladder and urethra and 7 nephrogenic adenoma-like clear cell adenocarcinomas were compared to 10 nephrogenic adenomas.
  • Classic clear cell adenocarcinoma was associated with urothelial carcinoma (n = 2) and endometriosis (n = 1).
  • The following antibodies were not helpful in distinguishing nephrogenic adenoma-like clear cell adenocarcinoma from nephrogenic adenoma: CD10, estrogen receptor, p63, high-molecular-weight cytokeratin, and alpha-methylacyl coenzyme-A racemase.
  • PAX2 expression was more frequent in nephrogenic adenoma (89%) compared to both patterns of clear cell adenocarcinoma (29%-32%).
  • The key features discriminating between nephrogenic adenoma-like clear cell adenocarcinoma and nephrogenic adenoma include occasional clear cells, more prominent pleomorphism especially hyperchromatic enlarged nuclei, and extensive muscular invasion.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Adenoma / diagnosis. Urethral Neoplasms / diagnosis. Urinary Bladder Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Urothelium / pathology

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  • [Copyright] Copyright 2010 Elsevier Inc.
  • (PMID = 20060152.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Farhat MH, Moumneh G, Jalloul R, El Hout Y: Secondary adenocarcinoma of the urinary bladder from a primary gastric cancer. J Med Liban; 2007 Jul-Sep;55(3):162-4
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  • [Title] Secondary adenocarcinoma of the urinary bladder from a primary gastric cancer.
  • Primary bladder tumor is a frequent urological malignancy, whereas the incidence of secondary bladder tumor from a distant organ is quite rare.
  • Secondary bladder neoplasms represent no more than 3% of all malignant bladder tumors in surgical specimens, of which distant metastases from stomach account for about 4%.
  • The signs of bladder neoplasm in a patient with malignancy elsewhere should alarm the clinician for a possible metastatic origin.
  • We present a patient with primary adenocarcinoma of the stomach, who underwent total gastrectomy and received adjuvant chemotherapy, and was diagnosed with metastasis to the urinary bladder 15 months later.
  • We review the epidemiology of secondary adenocarcinoma of the bladder, mechanisms of metastasis, associated common primaries with focus on gastric malignancies, radiological findings, and role of immunohistochemical staining.
  • [MeSH-major] Adenocarcinoma / secondary. Stomach Neoplasms / pathology. Urinary Bladder Neoplasms / secondary

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  • [CommentIn] J Med Liban. 2008 Jan-Mar;56(1):48 [19534093.001]
  • (PMID = 17966739.001).
  • [ISSN] 0023-9852
  • [Journal-full-title] Le Journal médical libanais. The Lebanese medical journal
  • [ISO-abbreviation] J Med Liban
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Lebanon
  • [Number-of-references] 16
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24. Bitar M, Mandel E, Kirschenbaum AM, Unger PD: Urinary bladder adenocarcinoma arising in a spina bifida patient. Ann Diagn Pathol; 2007 Dec;11(6):453-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Urinary bladder adenocarcinoma arising in a spina bifida patient.
  • Urinary bladder adenocarcinomas are rare malignancies accounting for approximately 2.5% of all urothelial neoplasms.
  • Intestinal metaplasia of the urothelium indicates the presence of intestinal-type goblet cells and was generally observed to coexist with or to precede the diagnosis of bladder adenocarcinomas.
  • Patients with neurogenic bladders are particularly at risk for developing bladder cancer, mostly squamous cell carcinoma and rarely adenocarcinoma.
  • In these patients, chronic irritation of the urothelium as well as long-term indwelling urinary catheters were the most significant risk factors.
  • Spina bifida is a congenital developmental abnormality that may result in neurogenic bladder.
  • There is only one previously reported case of urothelial carcinoma with associated squamous metaplasia of the bladder occurring in a spina bifida patient.
  • We report the first case of bladder adenocarcinoma associated with intestinal metaplasia occurring in a spina bifida occulta patient.
  • The patient had a complicated clinical course and suffered recurrent urinary tract infections, renal calculi, and urinary incontinence and was managed with intermittent as well as indwelling catheterization.
  • [MeSH-major] Adenocarcinoma, Mucinous / complications. Adenocarcinoma, Mucinous / pathology. Spinal Dysraphism / complications. Urinary Bladder Neoplasms / complications. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Humans. Immunohistochemistry. Intestines / pathology. Male. Metaplasia. Middle Aged. Precancerous Conditions / metabolism. Precancerous Conditions / pathology. Urinary Bladder, Neurogenic / complications

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  • (PMID = 18022132.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Bannowsky A, Wefer B, Osmonov D, Sotelino JA, Filippow N, Naumann CM, van der Horst Ch, Jünemann KP, Hautmann S: [Mesonephroid carcinoma of the urinary bladder (clear cell carcinoma). Two case reports and review of the literature in a rare variation of the primary adenocarcinoma]. Aktuelle Urol; 2007 May;38(3):247-51
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  • [Title] [Mesonephroid carcinoma of the urinary bladder (clear cell carcinoma). Two case reports and review of the literature in a rare variation of the primary adenocarcinoma].
  • Mesonephroid adenocarcinoma of the bladder may be a malignant form of nephrogenic adenoma or nephroid metaplasia.
  • The lesion is extremely rare in the urinary bladder, and to our knowledge 19 cases have been reported in the literature.
  • We report two cases of mesonephroid adenocarcinoma of the bladder which were treated by radical cystectomy.
  • [MeSH-major] Mesonephroma / diagnosis. Urinary Bladder Neoplasms / diagnosis
  • [MeSH-minor] Aged. Cystectomy. Diagnosis, Differential. Disease Progression. Follow-Up Studies. Humans. Lymph Node Excision. Male. Middle Aged. Neoplasm Staging. Prostatectomy. Urinary Bladder / pathology. Urinary Reservoirs, Continent

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  • (PMID = 17516385.001).
  • [ISSN] 0001-7868
  • [Journal-full-title] Aktuelle Urologie
  • [ISO-abbreviation] Aktuelle Urol
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 21
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26. Sung MT, Lopez-Beltran A, Eble JN, MacLennan GT, Tan PH, Montironi R, Jones TD, Ulbright TM, Blair JE, Cheng L: Divergent pathway of intestinal metaplasia and cystitis glandularis of the urinary bladder. Mod Pathol; 2006 Nov;19(11):1395-401
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Divergent pathway of intestinal metaplasia and cystitis glandularis of the urinary bladder.
  • Intestinal metaplasia has been proposed to be a precursor lesion of adenocarcinoma in the urinary bladder.
  • Tissues from 46 patients, including 22 cases of intestinal metaplasia of the urinary bladder, 11 cases of typical cystitis glandularis, and 13 cases containing both lesions, were selected and immunohistochemical stains for CDX2, Hep, cytokeratin 20 (CK20), and cytokeratin 7 (CK7) were performed.
  • Nuclear staining for CDX2 was observed in 29 of 35 (83%) cases of intestinal metaplasia of the urinary bladder.
  • In contrast, nuclear staining for CDX2 was not observed in any case of typical cystitis glandularis; however, seven of 24 (29%) cases showed aberrant cytoplasmic expression in a mean of 37% of cells.
  • In the urinary bladder, intestinal metaplasia and typical cystitis glandularis have sharply contrasting immunoprofiles.
  • Additionally, the absence of Hep staining in intestinal metaplasia of the urinary bladder, despite its morphologic resemblance to normal colonic mucosa and intestinal metaplasia in other organs, may signify the presence of unique metaplastic pathways in the urinary bladder.
  • [MeSH-major] Cystitis / pathology. Intestines / pathology. Precancerous Conditions / pathology. Urinary Bladder / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 16951671.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Autoantigens; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / KRT20 protein, human; 0 / KRT7 protein, human; 0 / Keratin-20; 0 / Keratin-7
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27. Grey BR, Clarke L, Maddineni SB, Hunt R, Brough RJ: Adenocarcinoma of the caecum metastatic to the bladder: an unusual cause of haematuria. BMC Urol; 2006;6:29
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma of the caecum metastatic to the bladder: an unusual cause of haematuria.
  • BACKGROUND: Primary malignancies of colorectal origin can metastasise to the bladder.
  • Subsequently, a metastatic lesion to the bladder was demonstrated and successfully excised by partial cystectomy.
  • CONCLUSION: In order that optimal therapeutic options can be determined, it is important for clinicians to distinguish between primary disease of the bladder and other causes of haematuria.
  • Various immunohistochemical techniques attempt to differentiate primary adenocarcinoma of the bladder from secondary colorectal adenocarcinoma.
  • Suspicion of metastatic disease must be raised when histologically unusual bladder tumours are identified.
  • [MeSH-major] Adenocarcinoma / complications. Adenocarcinoma / secondary. Cecal Neoplasms / complications. Cecal Neoplasms / diagnosis. Hematuria / diagnosis. Hematuria / etiology. Urinary Bladder Neoplasms / complications. Urinary Bladder Neoplasms / secondary
  • [MeSH-minor] Female. Humans. Rare Diseases / diagnosis. Rare Diseases / etiology

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  • [Cites] Am J Surg Pathol. 2001 Nov;25(11):1380-7 [11684954.001]
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  • (PMID = 17040576.001).
  • [ISSN] 1471-2490
  • [Journal-full-title] BMC urology
  • [ISO-abbreviation] BMC Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1624844
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28. Shigehara K, Taya T, Hisazumi H: Primary adenocarcinoma in the bladder diverticulum. Scand J Urol Nephrol; 2008;42(5):481-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary adenocarcinoma in the bladder diverticulum.
  • Cystoscopy revealed a papillary tumor within the diverticulum of the bladder.
  • A transurethral resection was performed and histopathological examination revealed adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Diverticulum / pathology. Urinary Bladder Diseases / pathology. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy. Cystectomy. Cystoscopy. Diagnosis, Differential. Hematuria / etiology. Humans. Male. Tomography, X-Ray Computed. Urinary Bladder / pathology

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  • (PMID = 18792856.001).
  • [ISSN] 0036-5599
  • [Journal-full-title] Scandinavian journal of urology and nephrology
  • [ISO-abbreviation] Scand. J. Urol. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
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29. Yenilmez A, Donmez T, Acikalin MF, Kale M: Adenonocarcinoma of the urinary bladder mimicking simple ureterocele: a case report. Int Urol Nephrol; 2007;39(2):465-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenonocarcinoma of the urinary bladder mimicking simple ureterocele: a case report.
  • We report a case of adenocarcinoma of the urinary bladder, mimicking simple ureterocele in a 55-year-old man, presenting irritative bladder symptoms.
  • Transurethral biopsy of the lesion was performed and pathological examination revealed a muscle-invasive adenocarcinoma.
  • The patient underwent radical cystectomy and urinary diversion.
  • [MeSH-major] Adenocarcinoma / diagnosis. Ureterocele / diagnosis. Urinary Bladder Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 17171419.001).
  • [ISSN] 0301-1623
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Hungary
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30. Zangrilli A, Saraceno R, Sarmati L, Orlandi A, Bianchi L, Chimenti S: Erysipeloid cutaneous metastasis from bladder carcinoma. Eur J Dermatol; 2007 Nov-Dec;17(6):534-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Erysipeloid cutaneous metastasis from bladder carcinoma.
  • Cutaneous metastases from bladder cancer are uncommon, especially in the female population.
  • We describe a 56-year-old female with a history of bladder adenocarcinoma (T3N0M0) who presented erythematous plaques with an erysipelas-like appearance located on the groins and thighs.
  • Histopathology and immunohistochemistry from skin lesions were consistent with metastases from bladder carcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Skin Neoplasms / secondary. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Erysipelas / diagnosis. Female. Humans. Immunohistochemistry. Middle Aged

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  • (PMID = 17951136.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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31. Adeniran AJ, Tamboli P: Clear cell adenocarcinoma of the urinary bladder: a short review. Arch Pathol Lab Med; 2009 Jun;133(6):987-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clear cell adenocarcinoma of the urinary bladder: a short review.
  • In this short review, we discuss clear cell adenocarcinoma of the urinary bladder, a rare tumor that primarily affects women.
  • Clear cell adenocarcinoma consists of cells with abundant clear cytoplasm, arranged in solid, glandular, or tubulocystic patterns.
  • [MeSH-major] Adenocarcinoma, Clear Cell. Urinary Bladder Neoplasms
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Prognosis

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  • (PMID = 19492895.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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32. Kösem M, Sengül E: Clear cell adenocarcinoma of the urinary bladder. Scand J Urol Nephrol; 2005;39(1):89-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clear cell adenocarcinoma of the urinary bladder.
  • Clear cell adenocarcinoma of the lower urinary tract, and particularly of the bladder, is a rare neoplasm and its histogenesis remains obscure.
  • The authors report the clinical and pathologic findings of a 55-year-old male with clear cell carcinoma of the bladder.
  • [MeSH-major] Adenocarcinoma, Clear Cell. Urinary Bladder Neoplasms
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Urinary Bladder / pathology

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  • (PMID = 15764280.001).
  • [ISSN] 0036-5599
  • [Journal-full-title] Scandinavian journal of urology and nephrology
  • [ISO-abbreviation] Scand. J. Urol. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Sweden
  • [Number-of-references] 15
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33. Rouache L, Cherif M, Tanneau Y, Gobet F, Pfister C: [Secondary appearance of a carcinoma in an excluded native bladder: Report of three cases]. Prog Urol; 2006 Nov;16(5):603-6
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  • [Title] [Secondary appearance of a carcinoma in an excluded native bladder: Report of three cases].
  • [Transliterated title] Apparition secondaire d'un carcinome sur vessie native exclue: à propos de trois cas.
  • INTRODUCTION: The management of congenital urological malformations is sometimes complex and may require urinary diversion.
  • Cystectomy is usually performed, but sometimes the bladder is left in place due to the presence of a pelvic cloaca and the morbidity related to this type of surgery.
  • MATERIAL: The authors report three cases of patients treated by urinary diversion for a congenital malformation without primary resection of the bladder RESULTS: In the absence of any infectious complications, bladder carcinoma on an excluded native bladder was diagnosed at the age of 3 years, 4 years and 38 years, respectively.
  • Histological examination showed transitional cell carcinoma in two cases and gastrointestinal-type adenocarcinoma of the bladder in 1 case.
  • CONCLUSION: The risk of secondary development of carcinoma in an excluded bladder during management of (congenital urological malformations is not negligible.
  • The authors also recommend cystoscopy and urine cytology with lavage to detect degeneration of the bladder mucosa.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Transitional Cell / diagnosis. Urinary Bladder / abnormalities. Urinary Bladder Neoplasms / diagnosis
  • [MeSH-minor] Adult. Humans. Male. Middle Aged. Urinary Diversion

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  • (PMID = 17175961.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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34. Mistry R, Ananthakrishnan K, Hamid BN, Powell C, Foster GE: Appendiceal carcinoma masquerading as recurrent urinary tract infections: case report and review of literature. Urology; 2006 Aug;68(2):428.e1-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appendiceal carcinoma masquerading as recurrent urinary tract infections: case report and review of literature.
  • We report on a female patient who presented with recurrent urinary tract infections.
  • The investigations revealed an adenocarcinoma of the appendix fistulating into the bladder and causing irritative symptoms.
  • This unusual situation reminds us that the finding of bladder adenocarcinoma is rare, and it would be prudent to examine the lower gastrointestinal tract thoroughly to look for a bowel source, before recommending any ablative surgery.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Urinary Tract Infections / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Recurrence

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  • (PMID = 16904475.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 14
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35. Gatto A, Falvo L, Sebastiani S, Roncolini G, Pinna G: Triple synchronous tumours of the urinary system with different histologies: a case report. Chir Ital; 2009 May-Jun;61(3):381-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Triple synchronous tumours of the urinary system with different histologies: a case report.
  • We present the case report of a male patient with a diagnosis of synchronous kidney, bladder and prostate tumours with different histologies: renal oncocytoma, urothelial carcinoma of the bladder, and adenocarcinoma of the prostate.
  • [MeSH-major] Cystectomy. Kidney Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / surgery. Nephrectomy. Prostatectomy. Prostatic Neoplasms / pathology. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adenoma, Oxyphilic / pathology. Aged. Carcinoma / pathology. Humans. Male. Risk Factors. Smoking / adverse effects. Treatment Outcome

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  • (PMID = 19694243.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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36. Osunkoya AO, Epstein JI: Primary mucin-producing urothelial-type adenocarcinoma of prostate: report of 15 cases. Am J Surg Pathol; 2007 Sep;31(9):1323-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary mucin-producing urothelial-type adenocarcinoma of prostate: report of 15 cases.
  • Prostatic urothelial-type adenocarcinoma arises through a process of glandular metaplasia of the prostatic urethral urothelium and subsequent in situ adenocarcinoma sometimes associated with villous adenoma.
  • These prostatic adenocarcinomas are analogous to nonurachal adenocarcinomas arising in the bladder from cystitis glandularis.
  • Only 2 cases of urothelial-type adenocarcinoma from an institution other than our own have been previously described.
  • The distinction between adenocarcinoma from another organ secondarily involving the prostate, usual adenocarcinoma of the prostate, and prostatic urothelial-type adenocarcinoma can present a significant diagnostic challenge and has significant therapeutic implications.
  • Fifteen cases of prostatic urothelial-type adenocarcinoma were retrieved from the consult files of one of the authors.
  • Mean patient age at diagnosis was 72 years (range 58 to 93 y).
  • Bladder primaries were ruled out clinically or pathologically in radical resection specimens.
  • Follow-up was available on all men with a mean of 50.3 months (range 2 to 161 mo).
  • All men presented with urinary obstruction symptoms with 3 (20%) also having mucusuria and 2 (13.3%) also having hematuria.
  • In 8/15 (53%) cases, glandular metaplasia of the prostatic urethra and contiguous transition to adenocarcinoma were identified.
  • Prostatic urothelial-type adenocarcinoma is a rare aggressive cancer arising in the prostate.
  • The differential diagnosis includes conventional prostatic mucinous adenocarcinoma and secondary infiltration from a colonic or bladder adenocarcinoma.
  • Immunohistochemistry for prostate specific antigen, prostate specific acid phosphatase, and high molecular weight cytokeratin along with morphology can help rule out conventional prostate carcinoma. beta-catenin, CDX2, and clinical studies are needed to rule out colonic adenocarcinoma.
  • As prostatic urothelial-type adenocarcinoma is entirely analogous to bladder adenocarcinoma in both, its morphology and immunophenotype, only clinical studies or in some cases pathologic examination of the cystoprostatectomy specimen can exclude infiltration from a primary bladder adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma, Mucinous / diagnosis. Mucins / analysis. Prostatic Neoplasms / diagnosis. Urothelium / pathology
  • [MeSH-minor] Acid Phosphatase. Aged. Aged, 80 and over. Cell Differentiation. Diagnosis, Differential. Follow-Up Studies. Homeodomain Proteins / analysis. Humans. Immunohistochemistry. Keratin-20 / analysis. Keratin-7 / analysis. Male. Middle Aged. Neoplasm Invasiveness. Prognosis. Prostate-Specific Antigen / analysis. Protein Tyrosine Phosphatases / analysis. Time Factors. beta Catenin / analysis

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  • (PMID = 17721186.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CDX2 protein, human; 0 / CTNNB1 protein, human; 0 / Homeodomain Proteins; 0 / KRT20 protein, human; 0 / KRT7 protein, human; 0 / Keratin-20; 0 / Keratin-7; 0 / Mucins; 0 / beta Catenin; EC 3.1.3.2 / Acid Phosphatase; EC 3.1.3.2 / prostatic acid phosphatase; EC 3.1.3.48 / Protein Tyrosine Phosphatases; EC 3.4.21.77 / Prostate-Specific Antigen
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37. Velcheti V, Govindan R: Metastatic cancer involving bladder: a review. Can J Urol; 2007 Feb;14(1):3443-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic cancer involving bladder: a review.
  • PURPOSE: Bladder cancer is the fourth most common cancer in men and the ninth most common cancer in women.
  • Bladder is not a common site for metastasis of cancer and often goes undiagnosed in the clinical follow up of cancer patients.
  • We reviewed the literature for published reports on metastatic cancer involving bladder.
  • MATERIALS AND METHODS: We searched MEDLINE, PubMed and OVID from 1953 to June 2005 for published reports on metastatic cancer involving bladder.
  • They key words used were bladder, cancer and metastatic.
  • All relevant articles reporting metastatic cancer to the bladder were reviewed.
  • RESULTS: We found 264 cases of metastasis to the bladder from various primary foci.
  • CONCLUSIONS: The definitive diagnosis of metastatic bladder cancers is often difficult, and poses a significant challenge to the physician, pathologist and the radiologist alike.
  • Bladder adenocarcinomas are uncommon and any adenocarcinoma of the bladder should be viewed with a high index of suspicion for a metastatic cancer from a distant focus.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Urinary Bladder Neoplasms / diagnosis. Urinary Bladder Neoplasms / secondary
  • [MeSH-minor] Breast Neoplasms / pathology. Canada / epidemiology. Colonic Neoplasms / pathology. Humans. Incidence. Rectal Neoplasms / pathology. Skin Neoplasms / pathology. Stomach Neoplasms / pathology. Urinary Bladder / pathology. Urinary Bladder / radiography. Urogenital Neoplasms / pathology

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  • (PMID = 17324324.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Canada
  • [Number-of-references] 100
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38. Chaleoykitti B: Preoperative diagnosis of urinary bladder involvement in adenocarcinoma of colon and rectum. J Med Assoc Thai; 2005 Dec;88(12):1816-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Preoperative diagnosis of urinary bladder involvement in adenocarcinoma of colon and rectum.
  • OBJECTIVE: Objective of the study was to compare urinary symptoms, urinalysis, computed tomography, intravenous pyelography, ultrasonography between colorectal adenocarcinoma with urinary bladder involvement and without urinary bladder involvement.
  • MATERIAL AND METHOD: Patients with adenocarcinoma of the colon and rectum who had the first operation between January 1999 and October 2004 were included in the present study.
  • All patients were divided into the bladder adhesion group and nonadhesion group.
  • Sex, sites of tumor, urinary symptoms and preoperative investigations were compared.
  • 26 cases (5.7%) had bladder adhesion.
  • Males had more chance of having bladder involvement.
  • Sigmoid and rectum were the most common sites of bladder adhesion.
  • All cases with urinary symptoms had bladder involvement.
  • All cases whose computed tomography showed bladder involvement had bladder adhesion during surgery.
  • Ultrasonography and IVP did not help in detection of bladder invasion.
  • CONCLUSION: History of urinary symptoms, urinalysis, computed tomography should be routinely performed in patients with adenocarcinoma of the sigmoid and rectum to detect urinary bladder involvement and to inform modes of urinary tract diversion to patients before surgery.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Colonic Neoplasms / pathology. Rectal Neoplasms / pathology. Urinary Bladder Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Urinary Bladder / pathology. Urination Disorders / diagnosis. Urination Disorders / etiology

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  • (PMID = 16518979.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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39. Smith AK, Hansel DE, Jones JS: Role of cystitis cystica et glandularis and intestinal metaplasia in development of bladder carcinoma. Urology; 2008 May;71(5):915-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Role of cystitis cystica et glandularis and intestinal metaplasia in development of bladder carcinoma.
  • OBJECTIVES: Cystitis cystica et glandularis (CCEG) and intestinal metaplasia (IM) have been suggested to represent precursors of bladder adenocarcinoma.
  • The relationship between these entities and the subsequent development of bladder carcinoma remains unclear.
  • METHODS: We retrospectively evaluated the association among florid CCEG, IM, and bladder carcinoma.
  • The records and imaging findings of patients with a pathologic diagnosis of florid CCEG and/or IM were reviewed for a concurrent or future diagnosis of bladder carcinoma or pelvic lipomatosis.
  • Of the 117 patients with CCEG, a subset was identified with concurrent mucinous adenocarcinoma (n = 1; <1%), squamous cell carcinoma (n = 4; 3%), or urothelial carcinoma (n = 34; 29%) at diagnosis.
  • Pure IM was identified concurrently with adenocarcinoma in 2 (10%), urothelial carcinoma in 4 (21%), and urothelial carcinoma with glandular differentiation in 1 (5%) of 19 patients.
  • CONCLUSIONS: Both florid CCEG and IM can be identified in benign bladder specimens or in conjunction with bladder carcinoma.
  • Although IM can be associated with a concurrent diagnosis of carcinoma, we found no evidence that it increases the future risk of malignancy and our findings do not support a recommendation for surveillance cystoscopy in such patients.
  • [MeSH-major] Cystitis / complications. Intestines / pathology. Precancerous Conditions / pathology. Urinary Bladder Neoplasms / etiology

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  • (PMID = 18455631.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. Geramizadeh B, Boub R, Rahsaz M: Histologic differentiation of hepatocellular carcinoma from adenocarcinoma by a simple panel: evaluation of the pitfalls. Indian J Pathol Microbiol; 2007 Jul;50(3):507-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histologic differentiation of hepatocellular carcinoma from adenocarcinoma by a simple panel: evaluation of the pitfalls.
  • The histological differentiation of Hepatocellular carcinoma (HCC) from cholangiocarcinoma (CC) and metastatic adenocarcinoma (MA) of the liver is difficult in some cases and immunohistochemistry (IHC) is necessary for the diagnosis.
  • HepPar-1 is a recently available antibody which seems to be very specific and sensitive for the diagnosis of HCC.
  • In this study we tried to apply these two markers for the diagnosis of HCC cases as a simple, useful and reliable panel.
  • We selected 101 liver tumors which had proven diagnosis by several antibodies and cilinicopathologic correlation.
  • The tumors with confirmed histologic diagnosis including 35 HCC, 58 MA, 7 CC and 1 combined HCC-CC.. HepPar-1 was positive in 30 of 35 cases of HCC; none of the other tumors were reactive for HepPar1 except for a case of metastatic gall bladder adenocarcinoma which showed areas of hepatoid differentiation in the H&E slides.
  • There were 4 cases of HCC with clear cell morphology, in most of which, IHC pattern was not diagnostic and further investigation was needed.
  • These two reliable markers are recommended for the initial step of differential diagnosis between HCC and MA and for the confirmation of the histologic diagnosis.
  • [MeSH-major] Adenocarcinoma / secondary. Antibodies, Monoclonal. Carcinoma, Hepatocellular / diagnosis. Cholangiocarcinoma / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / immunology. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Immunohistochemistry. Membrane Glycoproteins / immunology. Middle Aged

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  • (PMID = 17883119.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; 0 / Membrane Glycoproteins
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41. Sigalas K, Tyritzis SI, Trigka E, Katafigiotis I, Kavantzas N, Stravodimos KG: A male presenting with a primary mucinous bladder carcinoma: a case report. Cases J; 2010;3:49

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A male presenting with a primary mucinous bladder carcinoma: a case report.
  • BACKGROUND: The primary mucinous adenocarcinoma of the bladder is an extremely rare urologic entity, which is found in less than 2% of all urinary bladder tumours and is often presented as metastatic.
  • CASE PRESENTATION: A 69-year old male patient was diagnosed with a primary mucinous adenocarcinoma of the bladder after undergoing a transurethral resection of a bladder tumour and complete examination of the entire gastrointestinal tract to rule out other primary cites.
  • The patient underwent a radical cystoprostatectomy with en block bilateral pelvic lymphadenectomy and urinary diversion with a Bricker ileostomy.
  • CONCLUSION: The primary adenocarcinoma creates a diagnostic dilemma, since it cannot be easily differentiated by the adenocarcinoma that originates from the colon and the prostate.
  • The immunohistochemistry has a leading role, assisting with the differential diagnosis.

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  • [Cites] Sao Paulo Med J. 2007 Sep 6;125(5):297-9 [18094900.001]
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  • (PMID = 20205820.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2824640
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42. Datta C, Bhattacharyya S, Bhattacharya S, Ghosh S: Primary adenocarcinoma of bladder--A case report. J Indian Med Assoc; 2006 Jun;104(6):338-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary adenocarcinoma of bladder--A case report.
  • Ultrasonography depicted an echogenic mass on bladder wall, where prostate showed normal echo characters.
  • Cystoscopy revealed a large papillary growth involving lateral wall, neck of the urinary bladder and prostatic urethra.
  • Punched biopsy showed features of adenocarcinoma.
  • Radical cystectomy was performed and it was reported as a case of primary adenocarcinoma of the urinary bladder.
  • [MeSH-major] Adenocarcinoma / diagnosis. Urinary Bladder Neoplasms / diagnosis

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  • (PMID = 17058556.001).
  • [ISSN] 0019-5847
  • [Journal-full-title] Journal of the Indian Medical Association
  • [ISO-abbreviation] J Indian Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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43. Marques ML, D'Alessandro GS, Chade DC, Lanzoni VP, Saiovici S, Almeida CJ: Primary mucinous adenocarcinoma of the bladder with signet-ring cells: case report. Sao Paulo Med J; 2007 Sep 6;125(5):297-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary mucinous adenocarcinoma of the bladder with signet-ring cells: case report.
  • CONTEXT: Primary adenocarcinomas of the bladder are uncommon and usually occur by contiguity with or hematogenic dissemination of other adenocarcinomas such as colorectal, prostate and gynecological tract carcinomas.
  • Mucinous and signet-ring cell histological patterns are even rarer and it is often difficult to morphologically distinguish them from metastatic colorectal adenocarcinoma.
  • CASE REPORT: We present and discuss a rare case of primary mucinous adenocarcinoma of the bladder with signet-ring cells in a 57-year-old male patient.
  • Other primary sites for the tumor had been excluded and, in the absence of digestive tract tumor and for confirmation that it was a primary bladder tumor, an immunohistochemistry study was performed.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Carcinoma, Signet Ring Cell / diagnosis. Urinary Bladder Neoplasms / diagnosis
  • [MeSH-minor] Humans. Keratin-20 / analysis. Keratin-7 / analysis. Male. Middle Aged. Mucin-2. Mucins / analysis. Stomach Neoplasms / diagnosis

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  • (PMID = 18094900.001).
  • [ISSN] 1516-3180
  • [Journal-full-title] São Paulo medical journal = Revista paulista de medicina
  • [ISO-abbreviation] Sao Paulo Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Keratin-20; 0 / Keratin-7; 0 / MUC2 protein, human; 0 / Mucin-2; 0 / Mucins
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44. Chura JC, Brooker D, Downs LS Jr: Adenocarcinoma of the urinary bladder presenting as locally advanced endometrial carcinoma. Case report and review of the literature. Gynecol Oncol; 2006 Oct;103(1):336-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma of the urinary bladder presenting as locally advanced endometrial carcinoma. Case report and review of the literature.
  • BACKGROUND: Carcinoma of the urinary bladder that occurs after urinary diversion is a rare entity.
  • We report a case of an adenocarcinoma arising in a defunctionalized bladder that presented as locally advanced endometrial carcinoma.
  • She had a prior history of urinary diversion via a Koch pouch.
  • Examination revealed a mass protruding through the cervix and possibly involving the bladder anteriorly.
  • The patient underwent anterior pelvic exenteration for a locally advanced mucinous carcinoma thought to be arising from the uterus and invading into the bladder.
  • Final pathology, however, was consistent with a primary bladder carcinoma.
  • CONCLUSION: Carcinoma developing in the bladder after urinary diversion presents at an advanced stage and has associated poor overall survival.
  • [MeSH-major] Adenocarcinoma / diagnosis. Endometrial Neoplasms / diagnosis. Urinary Bladder Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Urinary Diversion / adverse effects

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  • (PMID = 16793125.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. Hungerhuber E, Bach E, Hartmann A, Frimberger D, Stief C, Zaak D: Adenocarcinoma of the bladder following nephrogenic adenoma: a case report. J Med Case Rep; 2008;2:164

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma of the bladder following nephrogenic adenoma: a case report.
  • We report a case of post-traumatic nephrogenic adenoma in a young patient without immunosuppression, which transformed into an adenocarcinoma of the bladder.
  • CASE PRESENTATION: A 25-year-old man had a traumatic bladder perforation caused by a car accident.
  • After physical recovery from the accident, he developed a neurogenic bladder and recurrent urinary tract infections.
  • He presented with nephrogenic adenoma of the bladder 18 months after the accident.
  • The initial pathologic findings were benign, however, the last resection revealed that the former benign adenoma had transformed into a moderately differentiated adenocarcinoma of the bladder (tumor present but no invasion, multifocal, no lymph nodes involved, no metastasis, grade 2).
  • However, patients with nephrogenic adenoma under immunosuppression and patients with neurogenic bladder dysfunction appear to be at a higher risk of developing bladder cancer.

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  • [Cites] J Urol. 1988 Jan;139(1):130-1 [3121867.001]
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  • (PMID = 18485239.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2396656
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46. Joseph B, Kumar M, de Bolla AR: Symptomatic bladder endocervicosis: does it need surgery? A case report and review of the literature. Urol Int; 2007;79(1):86-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Symptomatic bladder endocervicosis: does it need surgery? A case report and review of the literature.
  • Endocervicosis of the urinary bladder is a rare benign condition exclusively seen in women, usually of reproductive age.
  • It can be confused with an adenocarcinoma of the bladder.
  • Unless the correct diagnosis is made these patients can undergo potentially debilitating surgery.
  • [MeSH-major] Urinary Bladder Diseases / therapy

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  • (PMID = 17627176.001).
  • [ISSN] 0042-1138
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 10
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47. Orts JA, Morell L, Camps J, Traba ML, Belenguer A, Guerrero A: [Multiple enterolithiasis, coexisting with bladder and gallbladder lithiasis, associated with colon adenocarcinoma]. An Med Interna; 2005 May;22(5):227-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Multiple enterolithiasis, coexisting with bladder and gallbladder lithiasis, associated with colon adenocarcinoma].
  • [Transliterated title] Enterolitiasis múltiple, coexistiendo con litiasis biliar y vesical, asociada a adenocarcinoma de colon.
  • We report a case of multiple enterolithiasis, very infrequent pathology, coexisting with bladder and gall bladder lithiasis in a patient with colon adenocarcinoma.
  • Diagnosis was made by X-rays and CT images.
  • No risk factors for lithogenesis were found in this patient excluding the intestinal stasis caused by intestinal narrowing as a result of adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / complications. Calculi / complications. Cholelithiasis / complications. Colonic Neoplasms / complications. Intestinal Diseases / complications. Urinary Bladder Calculi / complications

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  • (PMID = 16001938.001).
  • [ISSN] 0212-7199
  • [Journal-full-title] Anales de medicina interna (Madrid, Spain : 1984)
  • [ISO-abbreviation] An Med Interna
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 27YLU75U4W / Phosphorus; I38ZP9992A / Magnesium; SY7Q814VUP / Calcium
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48. Adams B, Sawhney R, Sheil A, Chaudhary UB: A rare case of clear cell adenocarcinoma of the bladder with unique pathological features. Am J Med Sci; 2007 Jan;333(1):63-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare case of clear cell adenocarcinoma of the bladder with unique pathological features.
  • Clear cell adenocarcinomas of the urinary bladder are rare tumors with an unknown histogenesis.
  • While specific criteria for a diagnosis of clear cell adenocarcinoma have not been defined, there are consistent staining patterns suggested for characterization.
  • We present an important case of clear cell adenocarcinoma of the bladder with a unique staining pattern.
  • We review the literature and discuss the differential diagnosis and various theories concerning the origin of this rare tumor.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Adenocarcinoma, Clear Cell / surgery. Urinary Bladder Neoplasms / pathology. Urinary Bladder Neoplasms / surgery

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  • (PMID = 17220697.001).
  • [ISSN] 0002-9629
  • [Journal-full-title] The American journal of the medical sciences
  • [ISO-abbreviation] Am. J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CA-125 Antigen
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49. Bango García V, Luján Marco S, Bosquet Sanz M, Gimeno Argente V, Arlandis Guzmán S, Alonso Gorrea M, Jiménez Cruz F: [Primary bladder adenocarcinoma in unreconstructed exstrophic bladder]. Actas Urol Esp; 2009 Feb;33(2):197-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary bladder adenocarcinoma in unreconstructed exstrophic bladder].
  • [Transliterated title] Adenocarcinoma vesical primario en extrofia vesical no corregida.
  • We report a 60-years-old patient with a not repaired exstrophic bladder, who develops an adenocarcinoma on his bladder and review of the literature.
  • [MeSH-major] Adenocarcinoma / complications. Bladder Exstrophy / complications. Urinary Bladder Neoplasms / complications

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  • (PMID = 19418846.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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50. Izzo L, Pietrasanta D, Izzo P, Caputo M, Di Cello P, Meloni P, Bolognese A: A case of relapsing secondary bladder adenocarcinoma after right colonic cancer. Nat Clin Pract Urol; 2008 Jul;5(7):403-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of relapsing secondary bladder adenocarcinoma after right colonic cancer.
  • BACKGROUND: A 71-year-old woman was referred to a surgical oncology clinic after CT raised suspicion for a bladder neoplasm.
  • She had previously undergone right hemicolectomy and received adjuvant chemotherapy for pT3N1MX cancer of the cecum.
  • Follow-up CT raised suspicion for a possible bladder neoplasm.
  • DIAGNOSIS: Adenocarcinoma of the cecum metastatic to the bladder.
  • MANAGEMENT: The patient underwent open bladder resection with total excision of the neoplasm and was administered adjuvant chemotherapy consisting of irinotecan and cetuximab.
  • [MeSH-major] Adenocarcinoma / pathology. Cecal Neoplasms / pathology. Neoplasm Recurrence, Local / secondary. Urinary Bladder Neoplasms / secondary

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  • (PMID = 18604226.001).
  • [ISSN] 1743-4289
  • [Journal-full-title] Nature clinical practice. Urology
  • [ISO-abbreviation] Nat Clin Pract Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents, Phytogenic; 0 / Organoplatinum Compounds; 0 / Quinazolines; 0 / Thiophenes; 7673326042 / irinotecan; FCB9EGG971 / raltitrexed; PQX0D8J21J / Cetuximab; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin; Folfox protocol
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51. Rau AR, Kini H, Pai RR: Morphological evaluation of cystitis glandularis. Indian J Pathol Microbiol; 2009 Apr-Jun;52(2):203-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cystitis cystica and cystitis glandularis (CG) are relatively common appearances in the urinary bladder though CG may occasionally mimic a neoplasm.
  • This study was undertaken to study the morphology of CG and to highlight the differences in morphology between CG and adenocarcinoma.
  • One case of primary adenocarcinoma was included in this study, where the adjacent bladder mucosa showed CG.
  • Evaluation of the histological features of CG, especially intestinal type helps in correct categorization of this lesion and differentiation from adenocarcinoma of the bladder.
  • [MeSH-major] Cystitis / pathology. Urinary Bladder / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged, 80 and over. Child. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Urinary Bladder Neoplasms / pathology

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  • (PMID = 19332913.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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52. Kefeli M, Gonullu G, Can B, Malatyalioglu E, Kandemir B: Metastasis of adenocarcinoma of the gall bladder to an endometrial polyp detected by endometrial curettage: case report and review of the literature. Int J Gynecol Pathol; 2009 Jul;28(4):343-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastasis of adenocarcinoma of the gall bladder to an endometrial polyp detected by endometrial curettage: case report and review of the literature.
  • Breast carcinoma is the most frequent extragenital cancer that metastasizes to the endometrial polyp.
  • We report the case of a 63-year-old with metastatic gall bladder adenocarcinoma involving endometrial polyps detected by endometrial curetting.
  • After this diagnosis, bone metastases were detected during radiologic screening.
  • Gastrointestinal tumor metastasis to an endometrial polyp is a very rare event, but if a patient with a known primary extragenital tumor has abnormal vaginal bleeding, the possibility of metastasis should be included in the differential diagnosis.
  • [MeSH-major] Adenocarcinoma / secondary. Endometrial Neoplasms / secondary. Gallbladder Neoplasms / pathology. Polyps / pathology

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  • (PMID = 19483630.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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53. Kim SS, Choi YD, Nam JH, Kwon DD, Juhng SW, Choi C: Cytologic features of primary signet ring cell carcinoma of the bladder: a case report. Acta Cytol; 2009 May-Jun;53(3):309-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytologic features of primary signet ring cell carcinoma of the bladder: a case report.
  • BACKGROUND: Signet ring cell carcinoma is a very rare subtype of adenocarcinoma of the urinary bladder.
  • Urine cytology is a useful method for screening and followup of urinary bladder carcinoma.
  • Cystoscopy revealed very large masses in the anterior and posterior wall of the bladder.
  • Bladder washings, urine cytology and biopsy demonstrated characteristic signet ring cells without foci of urothelial carcinoma or other lesions.
  • CONCLUSION: Signet ring cell carcinoma of the urinary bladder can be diagnosed by urinary cytology and confirmed by cystoscopic biopsy.
  • [MeSH-major] Carcinoma, Signet Ring Cell / secondary. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Adult. Ascites / pathology. Biopsy. Fatal Outcome. Female. Hematuria / etiology. Hematuria / pathology. Humans. Therapeutic Irrigation. Tomography, X-Ray Computed. Urinalysis. Urinary Bladder / radiography

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  • (PMID = 19534273.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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54. Manassero F, Giannarini G, Paperini D, Mogorovich A, Alì G, Boggi U, Selli C: Simultaneous penile and signet ring cell bladder carcinoma in renal transplant recipient: a first case. ScientificWorldJournal; 2009;9:920-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Simultaneous penile and signet ring cell bladder carcinoma in renal transplant recipient: a first case.
  • The incidence and prevalence of cancer increase with time after transplantation.
  • The first case presented is one of a 65-year-old patient with a double genitourinary carcinoma (penis and bladder).
  • After adequate surgical treatment (partial amputation of the penis for squamous cell carcinoma and complete transurethral resection of bladder adenocarcinoma), the patient was noted to be free of tumor recurrence and had functioning renal graft with a 2-year follow-up.
  • [MeSH-major] Carcinoma, Signet Ring Cell / pathology. Kidney Transplantation / adverse effects. Penile Neoplasms / pathology. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Aged. Humans. Male. Urinary Bladder / pathology


55. Reid-Nicholson MD, Ramalingam P, Adeagbo B, Cheng N, Peiper SC, Terris MK: The use of Urovysion fluorescence in situ hybridization in the diagnosis and surveillance of non-urothelial carcinoma of the bladder. Mod Pathol; 2009 Jan;22(1):119-27
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The use of Urovysion fluorescence in situ hybridization in the diagnosis and surveillance of non-urothelial carcinoma of the bladder.
  • We evaluated Urovysion FISH in non-urothelial carcinoma involving bladder to determine its possible application to their diagnosis and surveillance.
  • Paraffin blocks from 31 non-urothelial bladder carcinomas, 12 pure urothelial carcinomas and 2 urothelial carcinomas with squamous differentiation were tested according to Vysis-Abbot Laboratories' recommended standards.
  • Cases included 15 primary squamous carcinoma, 2 urothelial carcinoma with squamous differentiation, 4 primary adenocarcinoma, 5 colonic, 4 prostatic and 1 cervical adenocarcinoma.
  • In conclusion, we found that chromosomal abnormalities tested for by Urovysion FISH may be seen in non-urothelial carcinomas of bladder.
  • These false-positive results were frequent in primary and secondary adenocarcinoma and rare in squamous carcinoma.
  • This has significant implications for the accurate diagnosis and management of patients with urinary tract cancer.
  • Urovysion FISH cannot be used to definitively diagnose squamous carcinoma or adenocarcinoma nor can it be used to differentiate the two from urothelial carcinoma.
  • However, it may be useful as a surveillance tool in established primary and secondary bladder adenocarcinoma.
  • [MeSH-major] In Situ Hybridization, Fluorescence / methods. Urinary Bladder Neoplasms / diagnosis. Urinary Bladder Neoplasms / genetics

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  • (PMID = 18978733.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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56. De Santis M, Bachner M: New developments in first- and second-line chemotherapy for transitional cell, squamous cell and adenocarcinoma of the bladder. Curr Opin Urol; 2007 Sep;17(5):363-8
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  • [Title] New developments in first- and second-line chemotherapy for transitional cell, squamous cell and adenocarcinoma of the bladder.
  • PURPOSE OF REVIEW: To review the systemic treatment, patient selection and treatment outcome of transitional cell carcinoma of the urinary bladder, squamous cell carcinoma and adenocarcinoma, focusing on advances and findings within the last year.
  • Only few data are available on the systemic treatment of squamous cell carcinoma and adenocarcinoma.
  • Complete resection seems to be more important than chemotherapy in the rare cases of adenocarcinoma of the urinary tract.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Transitional Cell / drug therapy. Urinary Bladder Neoplasms / drug therapy

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  • (PMID = 17762632.001).
  • [ISSN] 0963-0643
  • [Journal-full-title] Current opinion in urology
  • [ISO-abbreviation] Curr Opin Urol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin
  • [Number-of-references] 58
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57. El-Ghobashy A, Ohadike C, Wilkinson N, Lane G, Campbell JD: Recurrent urachal mucinous adenocarcinoma presenting as bilateral ovarian tumors on cesarean delivery. Int J Gynecol Cancer; 2009 Dec;19(9):1539-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent urachal mucinous adenocarcinoma presenting as bilateral ovarian tumors on cesarean delivery.
  • Metastases from the urinary tract are uncommon.
  • Primary adenocarcinoma of the bladder accounts for less than 1% of all bladder malignancies; one third of these tumors are urachal in origin.
  • Symptoms include hematuria, dysuria, frequency, urgency, and recurrent urinary tract infections.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Adenocarcinoma, Mucinous / diagnosis. Cesarean Section. Ovarian Neoplasms / diagnosis. Pregnancy Complications, Neoplastic / diagnosis. Urachus
  • [MeSH-minor] Adult. Delivery, Obstetric. Diagnosis, Differential. Female. Humans. Pregnancy

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  • (PMID = 19955933.001).
  • [ISSN] 1525-1438
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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58. Soares MJ, Neves T, Covita A, Monteiro P, Canhoto A, Nogueira R, Barreto JL, Mendonça JC, Maya M, Monteiro H: [Bladder adenocarcinoma. Case report]. Arch Esp Urol; 2008 Sep;61(7):828-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Bladder adenocarcinoma. Case report].
  • [Transliterated title] Adenocarcinoma vesical. Aportación de un caso clínico.
  • OBJECTIVE: Primary bladder adenocarcinoma is a rare entity.
  • METHOD/RESULTS: A 74 year old female patient presents to the emergency department with complaints of gross hematúria not accompanied by lower urinary tract symptoms.
  • Diagnostic work-up included renal and bladder ultrasound, cistoscopy and abdomino-pelvic C. T. scan.
  • Trans-urethral resection revealed an invasive adenocarcinoma.
  • The bladder specimen showed primary bladder adenocarcinoma, pT3aNO.
  • At 6 months of follow-up, the patient does not present disease progression or surgical complications.
  • CONCLUSION: Primary bladder adenocarcinoma is rare.
  • [MeSH-major] Adenocarcinoma. Urinary Bladder Neoplasms

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  • (PMID = 18972921.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 17
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59. Thomas AA, Stephenson AJ, Campbell SC, Jones JS, Hansel DE: Clinicopathologic features and utility of immunohistochemical markers in signet-ring cell adenocarcinoma of the bladder. Hum Pathol; 2009 Jan;40(1):108-16
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  • [Title] Clinicopathologic features and utility of immunohistochemical markers in signet-ring cell adenocarcinoma of the bladder.
  • Signet-ring adenocarcinoma is an aggressive form of primary bladder adenocarcinoma that has been associated with poor outcomes.
  • The utility of immunohistochemical markers in tumors with signet-ring morphology may vary from more typical adenocarcinomas arising at the same location, although this has not been examined in bladder adenocarcinoma.
  • We examined a series of bladder adenocarcinomas to determine the impact of signet-ring cell features on clinical outcomes and immunohistochemical findings.
  • We identified 25 patients with bladder adenocarcinoma, ranging in age from 28 to 78 years (mean, 57 years) and with a male-female ratio of 18:7.
  • Signet-ring cells occurred in 19 of 25 bladder adenocarcinomas (76%) and ranged from 5% to 100% of tumor volume, with most tumors demonstrating more than 60% signet-ring cell differentiation (15/19), when present.
  • A comparison between immunohistochemical markers frequently used to analyze bladder adenocarcinoma demonstrated decreased expression of several markers in signet-ring (n = 9) versus colonic-type (n = 8) morphology, including CDX-2, beta-catenin, and E-cadherin, although these results did not reach statistical significance.
  • In summary, the extent of signet-ring differentiation in bladder adenocarcinoma is associated with worsened survival and higher stage disease; the utility of immunohistochemical analysis in foci consisting of predominant signet-ring cells may be limited, although further studies that address this finding are needed.
  • [MeSH-major] Adenocarcinoma / pathology. Biomarkers, Tumor / analysis. Carcinoma, Signet Ring Cell / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 18789486.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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60. Giordano S, Taskinen S, Sankila A, Ala-Opas M: Adenocarcinoma in isolated rectal bladder after treatment of bladder exstrophy. Scand J Urol Nephrol; 2008;42(4):392-4
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  • [Title] Adenocarcinoma in isolated rectal bladder after treatment of bladder exstrophy.
  • We report the first Finnish patient with carcinoma in an augmented intestinal bladder, where urine and stools are not in contact.
  • The patient had undergone rectal bladder reconstruction at the age of 2 years because of bladder exstrophy.
  • When the patient was aged 46 years, a 2-cm, papillar, well-differentiated adenocarcinoma was detected and removed, preserving the rectal bladder.
  • [MeSH-major] Adenocarcinoma / diagnosis. Bladder Exstrophy. Urinary Bladder Neoplasms / diagnosis
  • [MeSH-minor] Child, Preschool. Humans. Male. Rectum / surgery. Urinary Bladder / abnormalities. Urinary Bladder / surgery

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  • (PMID = 19230174.001).
  • [ISSN] 0036-5599
  • [Journal-full-title] Scandinavian journal of urology and nephrology
  • [ISO-abbreviation] Scand. J. Urol. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
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61. Kim YH, Sung DJ, Cho SB, Chung KB, Cha SH, Park HS, Um JW: Complete eversion and prolapse of bladder concurrent with primary adenocarcinoma. Br J Radiol; 2006 Jul;79(943):e8-11
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  • [Title] Complete eversion and prolapse of bladder concurrent with primary adenocarcinoma.
  • Complete eversion and prolapse of the urinary bladder is extremely rare.
  • To the best of our knowledge, the imaging findings of complete bladder eversion have not been documented in the literature.
  • Here, we report a case of complete eversion and prolapse of the urinary bladder demonstrated on MRI.
  • Concurrent primary adenocarcinoma was found in the thickened wall of the everted urinary bladder.
  • [MeSH-major] Adenocarcinoma / diagnosis. Urinary Bladder Neoplasms / diagnosis

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  • (PMID = 16823055.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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62. Busto Martín LA, Janeiro Pais M, González Dacal J, Chantada Abal V, Busto Castañón L: Signet-ring cell adenocarcinoma of the bladder: case series between 1990-2009. Arch Esp Urol; 2010 Mar;63(2):150-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Signet-ring cell adenocarcinoma of the bladder: case series between 1990-2009.
  • OBJECTIVES: To present a revision on the signet-ring cell bladder adenocarcinomas found in our department.
  • METHODS/RESULTS: We reviewed all the transurethral resections of the bladder (TURB) performed between 1990 and 2009 finding 9 cases of primary signet ring cell adenocarcinomas (4 pure and 5 mixed).
  • Definitive treatment was radical cystectomy with Bricker's urinary diversion in four patients, cysctectomy with Mainz's II diversion in one patient and palliative management with TURB in three cases and percutaneous nephrostomy in the remaining case.
  • CONCLUSIONS: Signet-ring cell primary adenocarcinoma of the bladder is an uncommon type of tumor, with worse prognosis than transitional cell cancer.
  • [MeSH-major] Carcinoma, Signet Ring Cell. Urinary Bladder Neoplasms

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  • (PMID = 20378938.001).
  • [ISSN] 1576-8260
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
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63. Mukenge S, Pulitanò C, Colombo R, Negrini D, Ferla G: Secondary scrotal lymphedema: a novel microsurgical approach. Microsurgery; 2007;27(8):655-6
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  • We report a case of secondary lymphedema of male genitalia presenting more than 4 years after a radical cystectomy with extended pelvic lymphadenectomy for adenocarcinoma of the bladder.
  • [MeSH-major] Cystectomy / adverse effects. Lymphedema / surgery. Microsurgery / methods. Scrotum / surgery. Urinary Bladder Neoplasms / surgery

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  • (PMID = 17929261.001).
  • [ISSN] 0738-1085
  • [Journal-full-title] Microsurgery
  • [ISO-abbreviation] Microsurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Yasue H, Hanyu N, Usuba T, Abe M: [A case successfully treated with total pelvic exenteration after preoperative chemotherapy FOLFOX4 plus bevacizumab for unresectable sigmoid colon cancer with extramural progression]. Gan To Kagaku Ryoho; 2010 Feb;37(2):327-9
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  • [Title] [A case successfully treated with total pelvic exenteration after preoperative chemotherapy FOLFOX4 plus bevacizumab for unresectable sigmoid colon cancer with extramural progression].
  • After some examinations, we diagnosed pelvic tumor, bladder cancer (adenocarcinoma) and sigmoid colon cancer.
  • The pathological findings were very similar to sigmoid colon cancer, so we diagnosed that the pelvic tumor was sigmoid colon cancer with extramural progression.
  • This treatment appeared to be effective for unresectable primary colon cancer.

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  • (PMID = 20154496.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Organoplatinum Compounds; 2S9ZZM9Q9V / Bevacizumab; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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65. Petersen M, Meyer F, Kalinski T, Bischoff J, Bohr UR, Lippert H: [Rare neuroendocrine carcinoma of the gall bladder. Coincidental occurrence of an endometrioid ovarian adenocarcinoma]. Dtsch Med Wochenschr; 2009 Jan;134(1-2):19-22
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  • [Title] [Rare neuroendocrine carcinoma of the gall bladder. Coincidental occurrence of an endometrioid ovarian adenocarcinoma].
  • INVESTIGATIONS: Comparative immunochemistry, done to exclude metastatic growth of the previously demonstrated endometrioid ovarian carcinoma, was (1) negative for CK7 and CA125, positive for CK20, chromogranin A and synaptophysin (gall bladder and lymph node metastasis);.
  • DIAGNOSIS: The tumor lesion within the gall bladder and lymph node was classified as a neuroendocrine carcinoma, not a metastasis of the ovarian carcinoma.
  • TREATMENT AND CLINICAL COURSE: The patient underwent another laparotomy with resection of the stump of the cystic duct and the liver parenchyma surrounding the former gall bladder, including dissection of the lymph nodes within the hepatoduodenal ligament.
  • After 14 months another metastasis of the neuroendocrine carcinoma of the gall bladder was found.
  • But for eight years there has been no recurrence of the endometrioid adenocarcinoma of the left ovary.
  • This is the first case, according to the available literature, of an endometrioid adenocarcinoma of the ovary concomitant with a neuroendocrine carcinoma of the gall bladder.
  • [MeSH-major] Carcinoma, Endometrioid / diagnosis. Carcinoma, Neuroendocrine / diagnosis. Gallbladder Neoplasms / diagnosis. Neoplasms, Second Primary / diagnosis. Ovarian Neoplasms / diagnosis

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  • [ErratumIn] Dtsch Med Wochenschr. 2019 Sep;134(39):1915
  • (PMID = 19090447.001).
  • [ISSN] 1439-4413
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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66. Attallah AM, Sakr HA, Ismail H, Abdel-Hady el-SK, El-Dosoky I: An office-based immunodiagnostic assay for detecting urinary nuclear matrix protein 52 in patients with bladder cancer. BJU Int; 2005 Aug;96(3):334-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An office-based immunodiagnostic assay for detecting urinary nuclear matrix protein 52 in patients with bladder cancer.
  • OBJECTIVE: To report the rapid (5 min) and simple detection of a nuclear matrix protein (NMP) in the urine of patients with bladder cancer, using a newly developed office-based dot-enzyme-linked immunosorbent assay (ELISA).
  • PATIENTS AND METHODS: Western blot and specific immunoglobulin-G antibody were used to identify the urinary NMP marker.
  • Urine samples from 149 patients with bladder cancer and 72 controls were evaluated using the developed dot-ELISA.
  • RESULTS: The NMP marker was identified in the urine of patients with bladder cancer at 52 kDa (NMP-52) by Western blot.
  • The dot-ELISA detected the urinary NMP-52 marker in 92% of patients with squamous cell carcinoma, 98% with transitional cell carcinoma, and all six of those with adenocarcinoma of the bladder, with a specificity of 94%.
  • In addition, the NMP-52 tumour marker was not detected in the urine of patients who showed a response after radiotherapy.
  • CONCLUSION: Detecting the urinary NMP-52 marker using dot-ELISA would be helpful in the rapid diagnosis and follow-up of patients with bladder cancer.
  • [MeSH-major] Biomarkers, Tumor / urine. Nuclear Matrix-Associated Proteins / urine. Urinary Bladder Neoplasms / diagnosis

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  • (PMID = 16042726.001).
  • [ISSN] 1464-4096
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Nuclear Matrix-Associated Proteins
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67. Cruz-Gonzáles GH, Sánchez-Salas RE, Palmer-Román KJ, Sánchez-Rivero FR, Sánchez-Salas R, Daboin I, Mota D, León A: [Primary signet ring cell bladder adenocarcinoma. Case report with a multidisciplinary therapeutical approach]. Actas Urol Esp; 2007 Sep;31(8):919-22
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  • [Title] [Primary signet ring cell bladder adenocarcinoma. Case report with a multidisciplinary therapeutical approach].
  • [Transliterated title] Adenocarcinoma en células en anillo de sello primario de vejiga. Presentación de un caso clínico con tratamiento multidisciplinario.
  • INTRODUCTION: Bladder carcinoma is the second most frequent genitourinary tumor.
  • Adenocarcinoma accounts for up to 0.5 to 2% of bladder carcinoma types.
  • The pathology states the bladder adenocarcinomas are mucous secreting lesions with glandular, colloid or signet ring cell patterns.
  • Even the important advances reached in the field of bladder carcinoma, yet less frequent lesions as bladder adenocarcinoma do not have a standarized treatment protocol.
  • METHODS: Case report of a patient with primary signet ring cell bladder adenocarcinoma with a therapeutical multidisciplinary approach.
  • CONCLUSIONS: Bladder adenocarcionoma is a rare oncological entity.
  • [MeSH-major] Carcinoma, Signet Ring Cell. Urinary Bladder Neoplasms

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  • (PMID = 18020218.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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68. Xu T, Zhao WH, Wang XF, Huang XB, Xu QQ, Yang B, Ye XJ: [Analysis of pelvic lipomatosis and a case report of two brothers]. Beijing Da Xue Xue Bao; 2007 Aug 18;39(4):355-60
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  • A cystogram was performed and showed an elevated pear-shaped bladder secondary to thickening of the bladder wall.
  • Bladder and sigmoid were surrounded by homogeneous fat tissue.
  • Ileal bladder surgery was conducted.
  • Pelvic lipomatosis was a rare disorder of benign mature adipose tissue proliferation around the bladder and rectum, with urological or digestive system symptoms as the chief presentation.
  • Also there were risks of thrombosis, calculi and bladder adenocarcinoma.
  • The chief differential diagnosis was liposarcoma.
  • Currently, urinary diversion is the main treatment to relieve urinary obstruction.
  • [MeSH-major] Lipomatosis. Siblings. Urinary Bladder Diseases

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  • (PMID = 17657258.001).
  • [ISSN] 1671-167X
  • [Journal-full-title] Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
  • [ISO-abbreviation] Beijing Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] Pelvic lipomatosis
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69. Hao H, Tsujimoto M, Tsubamoto H, Komori S, Hirota S: Immunohistochemical phenotype of the urinary bladder endocervicosis: comparison with normal endocervix and well-differentiated mucinous adenocarcinoma of uterine cervix. Pathol Int; 2010 Jul;60(7):528-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical phenotype of the urinary bladder endocervicosis: comparison with normal endocervix and well-differentiated mucinous adenocarcinoma of uterine cervix.
  • Endocervicosis of the urinary bladder is a very rare tumor-like benign lesion.
  • Transvaginal ultrasound, cystoscopy and magnetic resonance imaging demonstrated a solid mass in the posterior wall of the bladder.
  • The mass was removed and histology revealed a haphazard proliferation of endocervical-type mucinous glands scattered through the muscularis propria of bladder wall.
  • Immunohistochemical phenotype of these glands was compared with three normal uterine endocervices and two cases of well-differentiated mucinous adenocarcinoma of the uterine cervix.
  • On the other hand, only glands of well-differentiated mucinous adenocarcinoma expressed human gastric mucin and showed high proliferative index of Ki-67.
  • Furthermore, diffuse distribution of estrogen and progesterone receptors, lack of human gastric mucin and low proliferative activity were distinct features for endocervicosis compared to well-differentiated mucinous adenocarcinoma.
  • [MeSH-major] Cervix Uteri. Choristoma / pathology. Urinary Bladder Diseases / pathology
  • [MeSH-minor] Adenocarcinoma, Mucinous / pathology. Adult. Cesarean Section. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Phenotype. Pregnancy. Uterine Cervical Neoplasms / metabolism. Uterine Cervical Neoplasms / pathology


70. Allaparthi S, Ramanathan R, Balaji KC: Robotic partial cystectomy for bladder cancer: a single-institutional pilot study. J Endourol; 2010 Feb;24(2):223-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Robotic partial cystectomy for bladder cancer: a single-institutional pilot study.
  • OBJECTIVE: Open partial cystectomy has been used as a curative option for select group of patients with bladder cancer.
  • In recent years, the da Vinci Surgical Robotic System is being increasingly used to perform complex urologic cancer surgeries.
  • We report first on a consecutive cohort of patients undergoing robotic partial cystectomy (RPC) for bladder cancer.
  • METHODS: Three consecutive patients underwent RPC, two with diagnosis of papillary neoplasm of bladder and one with urachal adenocarcinoma at our institution from July 2008 to January 2009.
  • Final pathology demonstrated high-grade carcinoma pT2bNxMx and pTaNxMx papillary urothelial carcinoma in two patients and invasive adenocarcinoma of the bladder pT3aNxMx in the remaining patient.
  • CONCLUSIONS: RPC is technically feasible using the da Vinci Surgical Robotic System in select patients with bladder cancer without disease recurrence in the short term.

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  • (PMID = 20039797.001).
  • [ISSN] 1557-900X
  • [Journal-full-title] Journal of endourology
  • [ISO-abbreviation] J. Endourol.
  • [Language] ENG
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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71. Hussein K, Nanda A, Al-Sabah H, Alsaleh QA: Sweet's syndrome (acute febrile neutrophilic dermatosis) associated with adenocarcinoma of prostate and transitional cell carcinoma of urinary bladder. J Eur Acad Dermatol Venereol; 2005 Sep;19(5):597-9
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  • [Title] Sweet's syndrome (acute febrile neutrophilic dermatosis) associated with adenocarcinoma of prostate and transitional cell carcinoma of urinary bladder.
  • In the present report, we describe an 82-year-old male with SS in association with adenocarcinoma of the prostate and transitional cell carcinoma of the urinary bladder.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Transitional Cell / pathology. Neoplasms, Multiple Primary / diagnosis. Prostatic Neoplasms / pathology. Sweet Syndrome / diagnosis. Urinary Bladder Neoplasms / pathology


72. Mai KT, Ahmed I, Robertson SJ, Belanger EC, Veinot JP, Islam S: Immunocytochemical study of urine cytological preparations from secondary prostatic adenocarcinoma involving the urinary bladder. Diagn Cytopathol; 2008 Oct;36(10):715-20
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  • [Title] Immunocytochemical study of urine cytological preparations from secondary prostatic adenocarcinoma involving the urinary bladder.
  • Involvement of the urinary bladder by prostatic adenocarcinoma (PCA) occasionally occurs.
  • In this study, we analyzed urine cytological findings in patients with secondary involvement of the urinary bladder by PCA with the help of the immunocytochemistry.
  • The diagnosis of PCA was made if the atypical cells were either immunoreactive for PSA or nonreactive for HMWCK.
  • The immunostaining supported the PCA diagnosis in all three cases from the prospective group and two cases in the retrospective group.
  • The positive diagnosis for PCA was based on the PSA immunoreactivity or nonreactivity to HMWCK and the cytological atypia.
  • In conclusions, immunostaining for PSA and HMWCK performed on cytospins of urine specimens from patients with a prior history of high-grade and/or stage of PCA is helpful to make a positive diagnosis of secondary bladder involvement from PCA.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / urine. Prostatic Neoplasms / pathology. Prostatic Neoplasms / urine. Urinary Bladder Neoplasms / secondary. Urinary Bladder Neoplasms / urine. Urine / cytology


73. Adley BP, Maxwell K, Dalton DP, Yang XJ: Urothelial-type adenocarcinoma of the prostate mimicking metastatic colorectal adenocarcinoma. Int Braz J Urol; 2006 Nov-Dec;32(6):681-7; discussion 687-8
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  • [Title] Urothelial-type adenocarcinoma of the prostate mimicking metastatic colorectal adenocarcinoma.
  • Adenocarcinoma arising in urinary bladder or prostatic urethra is uncommon.
  • Here we report the fifth case of a primary urothelial-type adenocarcinoma arising in the prostate which showed enteric differentiation.
  • The patient was a 55 year-old male whose prostatic needle core biopsy showed a high grade adenocarcinoma which was initially thought to be metastatic colon cancer.
  • Subsequent prostatectomy revealed a high grade adenocarcinoma which was positive for cytokeratins 7 and 20, carcinoembryonic antigen, CDX2, and high molecular weight cytokeratin, and negative for prostate specific antigen, prostate specific acid phosphatase and AMACR.
  • A diagnosis of urothelial-type adenocarcinoma of the prostate was rendered.
  • We review the literature regarding this entity, and discuss the differential diagnosis, emphasizing utility of immunohistochemistry in making the diagnosis.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Colorectal Neoplasms / pathology. Prostatic Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Necrosis. Prostatectomy. Urothelium

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  • (PMID = 17201946.001).
  • [ISSN] 1677-5538
  • [Journal-full-title] International braz j urol : official journal of the Brazilian Society of Urology
  • [ISO-abbreviation] Int Braz J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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74. Cimentepe E, Bayrak O, Unsal A, Koç A, Ataoğlu O, Balbay MD: Urethral adenocarcinoma mimicking urethral caruncle. Int Urogynecol J Pelvic Floor Dysfunct; 2006 Jan;17(1):96-8

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  • [Title] Urethral adenocarcinoma mimicking urethral caruncle.
  • We are presenting a 57-year-old female patient with a urethral lesion that looks like caruncle, but histopathologic examination of the excised lesion was reported as urethral adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Urethral Neoplasms / diagnosis
  • [MeSH-minor] Comorbidity. Female. Humans. Middle Aged. Urinary Bladder Diseases / epidemiology. Urinary Bladder Diseases / surgery

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  • (PMID = 15834509.001).
  • [Journal-full-title] International urogynecology journal and pelvic floor dysfunction
  • [ISO-abbreviation] Int Urogynecol J Pelvic Floor Dysfunct
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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75. Camilot D, Pizzolitto S, DeMaglio G, Falconieri G: Intravesical botryoid adenocarcinoma of the prostate: report of an unusual growth pattern of prostatic carcinoma simulating a urinary bladder tumor. Ann Diagn Pathol; 2007 Dec;11(6):413-6
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  • [Title] Intravesical botryoid adenocarcinoma of the prostate: report of an unusual growth pattern of prostatic carcinoma simulating a urinary bladder tumor.
  • We report on 3 cases of prostatic carcinoma presenting with a predominant intravesical mass as to simulate clinically and macroscopically a primary tumor of the urinary bladder.
  • All patients had a medical history of a prostatic adenocarcinoma diagnosed between 5 and 7 years earlier and treated conservatively.
  • Because of instrumental evidence of a large urinary bladder mass, 2 patients underwent radical cystoprostatectomy based on suspicions for a primary urothelial tumor.
  • Either cystoscopic or direct specimen inspection revealed a lobulated, yellow-tan, and polypoid lesion with a broad implant in the trigonal bladder area in 1 case and a mixed, polypoid, and diffuse linitis plastica-like infiltration of the bladder wall in the other 2 cases.
  • Microscopically, sections of tumor mass as well as from the prostate featured a poorly differentiated adenocarcinoma compatible with the prostatic origin.
  • [MeSH-major] Adenocarcinoma / secondary. Neoplasm Recurrence, Local / pathology. Prostatic Neoplasms / pathology. Urinary Bladder Neoplasms / secondary
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male

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  • (PMID = 18022125.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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76. McKenney JK, Amin MB: The role of immunohistochemistry in the diagnosis of urinary bladder neoplasms. Semin Diagn Pathol; 2005 Feb;22(1):69-87
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The role of immunohistochemistry in the diagnosis of urinary bladder neoplasms.
  • The spectrum of neoplasms involving the urinary bladder is diverse, and, at times, different entities with distinct prognostic and managerial implications may have significant morphologic overlap.
  • The presence of a neoplasm with an unusual morphologic appearance, such as an undifferentiated spindled, or plasmacytoid pattern may necessitate immunohistochemistry to establish the diagnosis.
  • In this review, we discuss a series of distinct diagnostic scenarios, including high-grade undifferentiated carcinoma versus prostatic adenocarcinoma, enteric-type adenocarcinoma versus secondary colorectal adenocarcinoma, spindle cell proliferations, neoplasms with plasmacytoid morphology, endophytic tumors with a nested growth pattern, and flat urothelial lesions with atypia.
  • The importance of using a morphologically derived differential diagnosis to guide the selection and interpretation of immunohistochemical studies is emphasized, and the varying utility (specificity) of the individual immunohistochemical markers within each setting is addressed.
  • [MeSH-major] Immunohistochemistry. Urinary Bladder Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adult. Biomarkers, Tumor / analysis. Carcinoma / diagnosis. Carcinoma / pathology. Child. Diagnosis, Differential. Humans. Male. Neoplasm Metastasis. Neoplasms, Unknown Primary / diagnosis. Precancerous Conditions. Prostatic Neoplasms / pathology

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  • (PMID = 16512600.001).
  • [ISSN] 0740-2570
  • [Journal-full-title] Seminars in diagnostic pathology
  • [ISO-abbreviation] Semin Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 62
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77. Berberian JP, Goeman L, Allory Y, Abbou CC, Salomon L: Adenocarcinoma of ileal neobladder 20 years after cystectomy. Urology; 2006 Dec;68(6):1343.e9-10
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  • [Title] Adenocarcinoma of ileal neobladder 20 years after cystectomy.
  • We present the case of a 67-year-old man with adenocarcinoma of the ileal neobladder 20 years after radical cystoprostatectomy for Stage pT2 transitional bladder cell cancer.
  • [MeSH-major] Adenocarcinoma / pathology. Cystectomy / methods. Ileal Neoplasms / pathology. Urinary Diversion
  • [MeSH-minor] Aged. Carcinoma, Transitional Cell / pathology. Carcinoma, Transitional Cell / surgery. Cystoscopy. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Reoperation. Time Factors. Urinary Bladder Neoplasms / pathology. Urinary Bladder Neoplasms / surgery

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  • (PMID = 17141834.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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78. Marquez Moreno AJ, Gomez Rebollo C, Antuña Calle F, Perez Villa L, Sanchez Carrillo JJ, Julve Villalta E, Blanes Berenguel A, Martin Palanca A: Urachal adenocarcinoma with late brain metastases. Arch Esp Urol; 2010 Sep;63(7):550-4
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  • [Title] Urachal adenocarcinoma with late brain metastases.
  • OBJECTIVE: To describe a case of urachal adenocarcinoma with late brain metastases in a sixty one year old man who presented abdominal discomfort and hematuria during six months.
  • METHODS: The clinical suspicion was bladder tumor and diagnostic studies were performed (urinary cytology, cystoscopy, abdominal ultrasound and abdominopelvic CT scan).
  • RESULTS: Negative urinary cytology.
  • Cystoscopy showed a lesion with infiltration of the bladder dome.
  • Ultrasound and CT scan showed a five centimeter rounded lesion, with intermediate density, internal echoes and calcifications on the anterior supravesical middle line, that infiltrated the bladder.
  • The extension study had not findings.
  • The histopathologic diagnosis was mucin-secreting urachal adenocarcinoma.
  • CONCLUSIONS: Urachal adenocarcinoma is a tumor which must be distinguished of primary bladder adeno-carcinoma.
  • The mucing-secreting adenocarcinoma can be associated with calcifications that can be demostrated on imaging studies.
  • [MeSH-major] Adenocarcinoma / secondary. Brain Neoplasms / secondary. Urachus

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  • (PMID = 20945591.001).
  • [ISSN] 1576-8260
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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79. Martínez-Cornelio A, Flores-López D, Ojeda RF, Quintero-Becerra J, Hernández-Toriz N: [Surgical experience with urachal carcinoma]. Cir Cir; 2009 Jan-Feb;77(1):33-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Experiencia quirúrgica en el adenocarcinoma de uraco.
  • BACKGROUND: Urachal carcinomas are rare neoplasms that constitute <1% of bladder tumors.
  • Clinical files were reviewed of patients with diagnosis of bladder cancer and who were operated on with radical cystectomy with urinary substitution and extended partial cystectomy, selecting those patients with pathological report of urachal carcinoma.
  • RESULTS: Of the 306 patients operated on with radical surgery for bladder cancer, only five patients (1.6%) had a diagnosis of urachal carcinoma.
  • In the other four cases, tumor was reported in the dome of the bladder and for this reason cystoscopy and transurethral resection of the bladder (TURB) were done, confirming the clinical findings in addition to the pathology report suggesting urachal carcinoma.
  • This was the reason for the Studer-type orthotopic bladder substitution.
  • Symptoms in most cases are similar to those of bladder pathology origin.
  • [MeSH-major] Adenocarcinoma / surgery. Urachus. Urinary Bladder Neoplasms / surgery

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  • (PMID = 19344561.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
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80. Mai KT, Nguyen B: Urothelial carcinoma and prostatic adenocarcinoma presenting as collision tumors. Can J Urol; 2009 Oct;16(5):4850-3
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  • [Title] Urothelial carcinoma and prostatic adenocarcinoma presenting as collision tumors.
  • Urothelial carcinoma (UC) and prostatic adenocarcinoma (PAC) commonly occur in elderly patients and share common carcinogenic factors that could be identified in the urine.
  • Simultaneous occurrence of PAC and UC in the prostate is not uncommon; however, urinary bladder location of both lesions has not yet been reported.
  • Furthermore, invasion into the urinary bladder wall by a PAC can also pose a diagnostic challenge with UC and other primary urinary bladder tumors.
  • We report three patients presenting with UC and PAC within the urinary bladder.
  • All patients were diagnosed with high grade PAC and either had simultaneous at the initial diagnosis or developed UC during the follow up for PAC.
  • In conclusion, awareness of this association is important in making the correct diagnosis, especially when dealing with urinary bladder biopsy material.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Neoplasms, Multiple Primary. Prostatic Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Biopsy. Combined Modality Therapy. Cystoscopy. Diagnosis, Differential. Fatal Outcome. Humans. Male

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  • (PMID = 19796465.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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81. Kagami S, Saeki H, Idezuki T, Yano S, Kawabata Y, Okochi H, Asahina A, Nakagawa K, Tamaki K: Epithelioid sarcoma associated with lung adenocarcinoma. J Dermatol; 2005 Nov;32(11):904-8
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  • [Title] Epithelioid sarcoma associated with lung adenocarcinoma.
  • His mother and father had died of rectal and bladder carcinoma, respectively, and he had also had a seminoma previously.
  • A lung biopsy revealed that he had well-differentiated adenocarcinoma which expressed p53.
  • Mutations in the TP53 gene were not searched for.
  • We selected conservative treatment because the patient did not want surgical wide resection or amputation.
  • The size of the ulcer and the tumor invasion along the fasciae of muscles were decreased, however, metastasis of the epithelioid sarcoma was detected in the lymph node of the left axilla four years after the diagnosis.
  • [MeSH-major] Adenocarcinoma / diagnosis. Lung Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Sarcoma / diagnosis. Skin Neoplasms / diagnosis


82. Wright JL, Porter MP, Li CI, Lange PH, Lin DW: Differences in survival among patients with urachal and nonurachal adenocarcinomas of the bladder. Cancer; 2006 Aug 15;107(4):721-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differences in survival among patients with urachal and nonurachal adenocarcinomas of the bladder.
  • BACKGROUND: Primary adenocarcinomas of the bladder and urachus are rare malignancies, and knowledge of the patient demographics, pathologic characteristics, and survival associated with these tumors is poor.
  • The current study compares disease-specific characteristics and survival associated with urachal and nonurachal primary bladder adenocarcinomas.
  • METHODS: Incident cases of urachal and nonurachal primary adenocarcinomas of the bladder were identified from the Surveillance, Epidemiology, and End Results (SEER) Program.
  • Demographic and pathologic characteristics at the time of diagnosis were compared.
  • Risks of mortality among urachal and nonurachal primary adenocarcinomas of the bladder were compared using multivariate Cox regression.
  • RESULTS: A total of 151 urachal and 1374 nonurachal adenocarcinomas of the bladder patients were identified.
  • Compared to those with nonurachal tumors, patients with urachal adenocarcinoma were more likely to be younger (median age, 56 vs. 69 years, P <.0001) and female (45% vs. 36%, P = .02).
  • CONCLUSIONS. Urachal adenocarcinomas represent 10% of all primary adenocarcinomas of the bladder.
  • [MeSH-major] Adenocarcinoma / mortality. Urachus. Urinary Bladder Neoplasms / mortality

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  • (PMID = 16826584.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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83. Panebianco V, Sciarra A, Di Martino M, Bernardo S, Vergari V, Gentilucci A, Catalano C, Passariello R: Bladder carcinoma: MDCT cystography and virtual cystoscopy. Abdom Imaging; 2010 Jun;35(3):257-64
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  • [Title] Bladder carcinoma: MDCT cystography and virtual cystoscopy.
  • Bladder carcinoma is the most common tumor among the low urinary tract, accounting for 90% of cancer cases.
  • Conventional cystoscopy represents the gold standard for diagnosis and local management of bladder carcinoma.
  • Additionally, conventional cystoscopy does not provide information about extravescical extensions of the tumor.
  • We presents the CT cystography findings with virtual endoscopy correlation and bladder carcinoma appearance.
  • [MeSH-major] Cystoscopy / methods. Tomography, X-Ray Computed / methods. Urinary Bladder Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / pathology. Carcinoma, Squamous Cell / pathology. Female. Humans. Male. Neoplasm Invasiveness. Neoplasm Staging

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  • (PMID = 19471998.001).
  • [ISSN] 1432-0509
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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84. Hameed O, Humphrey PA: Pseudoneoplastic mimics of prostate and bladder carcinomas. Arch Pathol Lab Med; 2010 Mar;134(3):427-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pseudoneoplastic mimics of prostate and bladder carcinomas.
  • CONTEXT: The differential diagnoses of prostatic carcinoma and bladder epithelial neoplasms include several histologic mimics that should be known to avoid misdiagnosis.
  • OBJECTIVE: To discuss pseudoneoplastic lesions of the prostate and bladder that could potentially be confused with prostatic carcinoma and bladder epithelial neoplasms, respectively, with specific focus on their distinguishing histopathologic features.
  • Such lesions often mimic lower-grade prostatic adenocarcinoma, whereas others, such as clear cell cribriform hyperplasia and granulomatous prostatitis, for example, are in the differential diagnosis of Gleason adenocarcinoma, Gleason grade 4 or 5.
  • Pseudoneoplastic lesions of the urinary bladder include lesions that could potentially be confused with urothelial carcinoma in situ, such as reactive urothelial atypia, and others, such as polypoid/papillary cystitis, where papillary urothelial neoplasms are the main differential diagnostic concern.
  • Diagnostic awareness of the salient histomorphologic and relevant immunohistochemical features of these prostatic and urinary bladder pseudoneoplasms is critical to avoid rendering false-positive diagnoses of malignancy.
  • [MeSH-major] Granuloma, Plasma Cell / diagnosis. Prostatic Diseases / diagnosis. Urinary Bladder Diseases / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Prostatic Neoplasms / classification. Prostatic Neoplasms / diagnosis. Urinary Bladder Neoplasms / classification. Urinary Bladder Neoplasms / diagnosis

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  • (PMID = 20196670.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 83
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85. Vemulakonda VM, Lendvay TS, Shnorhavorian M, Joyner BD, Kaplan H, Mitchell ME, Grady RW: Metastatic adenocarcinoma after augmentation gastrocystoplasty. J Urol; 2008 Mar;179(3):1094-6; discussion 1097
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic adenocarcinoma after augmentation gastrocystoplasty.
  • PURPOSE: Augmentation gastrocystoplasty has been proposed as an alternative to enterocystoplasty because of potential benefits, including decreased risk of mucus production, stone formation and urinary tract infections.
  • Although cancer has rarely been reported in this patient population, it is a well recognized potential risk of all augmentation cystoplasties.
  • To define better the risk of malignancy associated with gastric augmentation and the appropriate surveillance protocol for these patients, we describe our experience in 2 patients with metastatic adenocarcinoma following gastrocystoplasty.
  • Of the 72 patients identified 2 were diagnosed with a primary malignancy arising from the augmented bladder.
  • RESULTS: Two patients were identified with a primary bladder malignancy after gastrocystoplasty.
  • Neither patient had a history of gross hematuria, recurrent urinary tract infections or pain before initial presentation.
  • Mean age at diagnosis of malignancy was 19.5 years, with a mean time from augmentation of 14 years.
  • CONCLUSIONS: Although the risk of bladder cancer is low after gastric augmentation, the effects may be life threatening.
  • Therefore, we advocate routine annual surveillance with cystoscopy, bladder biopsy and upper tract imaging in all patients who have undergone augmentation gastrocystoplasty.
  • [MeSH-major] Adenocarcinoma / etiology. Stomach Neoplasms / etiology. Urinary Bladder Neoplasms / etiology. Urologic Surgical Procedures / adverse effects
  • [MeSH-minor] Adult. Anastomosis, Surgical. Child. Child, Preschool. Humans. Male. Retrospective Studies. Stomach / surgery. Urethral Diseases / surgery. Urinary Bladder / surgery. Urologic Diseases / surgery

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  • (PMID = 18206936.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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86. Akhtar M, Gallagher L, Rohan S: Survivin: role in diagnosis, prognosis, and treatment of bladder cancer. Adv Anat Pathol; 2006 May;13(3):122-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Survivin: role in diagnosis, prognosis, and treatment of bladder cancer.
  • In the case of bladder cancer, survivin is expressed in the neoplastic epithelium but not in the uninvolved mucosa.
  • Several studies on bladder cancer have indicated that there may be a relationship between survivin expression and ultimate behavior of the carcinoma, although the exact nature of this relationship is still not fully understood, because the results of some of these studies seem to be contradictory.
  • As survivin is differentially expressed in bladder cancer and not in the normal urothelium, several studies have demonstrated efficacy of urine testing of survivin as a diagnostic tool for an early detection of bladder cancer.
  • Survivin has also been suggested as a suitable target for developing specific therapy for local treatment of bladder cancer with encouraging initial results.
  • Thus, survivin is a potentially significant protein with a crucial role in the diagnosis, prognosis, and treatment of bladder cancer.
  • [MeSH-major] Adenocarcinoma / metabolism. Microtubule-Associated Proteins / metabolism. Neoplasm Proteins / metabolism. Urinary Bladder Neoplasms / metabolism
  • [MeSH-minor] Apoptosis. Biomarkers, Tumor / metabolism. Early Diagnosis. Humans. Inhibitor of Apoptosis Proteins. Prognosis

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  • (PMID = 16778475.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Biomarkers, Tumor; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins
  • [Number-of-references] 25
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87. Hosseini SY, Danesh AK, Parvin M, Basiri A, Javadzadeh T, Safarinejad MR, Nahabedian A: Incidental prostatic adenocarcinoma in patients with PSA less than 4 ng/mL undergoing radical cystoprostatectomy for bladder cancer in Iranian men. Int Braz J Urol; 2007 Mar-Apr;33(2):167-73; discussion 173-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Incidental prostatic adenocarcinoma in patients with PSA less than 4 ng/mL undergoing radical cystoprostatectomy for bladder cancer in Iranian men.
  • OBJECTIVE: To assess the incidence of prostate adenocarcinoma in patients undergoing radical cystoprostatectomy due to bladder cancer in Iranian men.
  • MATERIALS AND METHODS: Fifty cystoprostatectomy specimens removed due to bladder malignancy (2004-2005) at two referral centers (Shaheed Modarress and Shaheed Labbafinejad Hospitals, Tehran, Iran) were examined for the coincidental finding of prostate cancer (PCa).
  • RESULTS: Incidentally detected cancer was found in 7 (14%) of cystoprostatectomy specimens.
  • HGPIN was present in 1 (14.3%) of the cystoprostatectomies with incidentally detected prostate cancer.
  • None of cystoprostatectomies without prostate cancer had HGPIN.
  • CONCLUSION: We conclude that incidentally detected prostate cancer in Iran is lower than the rates reported in other countries.
  • Further studies are warranted for better declaration of variability of prostate cancer between different ethnic groups.
  • [MeSH-major] Adenocarcinoma / diagnosis. Prostate-Specific Antigen / blood. Prostatic Neoplasms / diagnosis. Urinary Bladder Neoplasms / surgery


88. Abol-Enein H, Kava BR, Carmack AJ: Nonurothelial cancer of the bladder. Urology; 2007 Jan;69(1 Suppl):93-104
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  • [Title] Nonurothelial cancer of the bladder.
  • In this article, we review available evidence on the treatment of patients with nonurothelial cancer of the bladder.
  • Squamous cell carcinoma and adenocarcinoma are ideally treated with radical cystectomy.
  • Other rarer tumors of the bladder are also discussed.
  • [MeSH-major] Carcinoma, Squamous Cell. Urinary Bladder Neoplasms
  • [MeSH-minor] Combined Modality Therapy. Diagnosis, Differential. Global Health. Humans. Survival Rate

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  • (PMID = 17280911.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 119
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89. Anjaneyulu V, Shankar-Swarnalatha G, Rao SC: Carcinoid tumor of the gall bladder. Ann Diagn Pathol; 2007 Apr;11(2):113-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoid tumor of the gall bladder.
  • Carcinoid of the gall bladder and bile duct is a rare tumor.
  • Primary gall bladder and biliary duct system carcinoids constitute less than 1% of all carcinoid tumors arising from different parts of the body.
  • We describe a case of carcinoid tumor of the gall bladder in a 53-year-old woman.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunoenzyme Techniques. Middle Aged. Silver Nitrate. Silver Staining. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17349570.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Grimelius stain; 95IT3W8JZE / Silver Nitrate
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90. Kaufman DS, Shipley WU, Feldman AS: Bladder cancer. Lancet; 2009 Jul 18;374(9685):239-49
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bladder cancer.
  • Bladder cancer is a heterogeneous disease, with 70% of patients presenting with superficial tumours, which tend to recur but are generally not life threatening, and 30% presenting as muscle-invasive disease associated with a high risk of death from distant metastases.
  • The main presenting symptom of all bladder cancers is painless haematuria, and the diagnosis is established by urinary cytology and transurethral tumour resection.
  • The standard of care for muscle-invasive disease is radical cystoprostatectomy, and several types of urinary diversions are offered to patients, with quality of life as an important consideration.
  • Bladder preservation with transurethral tumour resection, radiation, and chemotherapy can in some cases be equally curative.
  • We discuss bladder preserving approaches, combination chemotherapy including new agents, targeted therapies, and advances in molecular biology.
  • [MeSH-major] Urinary Bladder Neoplasms
  • [MeSH-minor] Adenocarcinoma / epidemiology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Transitional Cell / epidemiology. Chemotherapy, Adjuvant. Combined Modality Therapy. Cystectomy. Cystoscopy. Diagnosis, Differential. Hematuria / etiology. Humans. Molecular Biology. Neoadjuvant Therapy. Neoplasm Staging. Prostatectomy. Risk Factors. Sensitivity and Specificity. Survival Rate. United States / epidemiology. Urinary Diversion


91. Tanaka H, Masuda H, Komai Y, Yokoyama M, Iwai A, Numao N, Sakai Y, Saito K, Fujii Y, Kobayashi T, Kawakami S, Kihara K: [Primary adenocarcinoma of the female urethra treated by multimodal therapy]. Hinyokika Kiyo; 2009 Jan;55(1):43-6

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  • [Title] [Primary adenocarcinoma of the female urethra treated by multimodal therapy].
  • A 64-year old female presented with urinary retention.
  • Pathological examinations of the transurethral and transvaginal needle biopsy specimen suggested mucinous adenocarcinoma.
  • Then she underwent total cysto-urethrectomy with anterior vaginal wall resection, pelvic lymphadenectomy, and urinary diversion with ureterocutaneous fistula.
  • Histopathological examination of the surgical specimen showed mutinous adenocarcinoma invading to the vesical triangle and the anterior vaginal wall.
  • The final diagnosis was urethral adenocarcinoma, pT4N0, Stage IV.
  • [MeSH-major] Adenocarcinoma, Mucinous / therapy. Urethral Neoplasms / therapy
  • [MeSH-minor] Combined Modality Therapy. Fatal Outcome. Female. Humans. Middle Aged. Neoplasm Invasiveness. Urinary Bladder Neoplasms / pathology. Urinary Bladder Neoplasms / therapy. Vaginal Neoplasms / pathology. Vaginal Neoplasms / therapy

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  • (PMID = 19227213.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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92. Crow P, Molckovsky A, Stone N, Uff J, Wilson B, WongKeeSong LM: Assessment of fiberoptic near-infrared raman spectroscopy for diagnosis of bladder and prostate cancer. Urology; 2005 Jun;65(6):1126-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Assessment of fiberoptic near-infrared raman spectroscopy for diagnosis of bladder and prostate cancer.
  • OBJECTIVES: To determine whether a fiberoptic Raman system, suitable for in vivo use, is able to differentiate between benign and malignant bladder and prostate pathologic findings in vitro.
  • Laboratory studies have shown that the technique can be used to identify and characterize transitional cell carcinoma and prostate adenocarcinoma in vitro.
  • METHODS: A total of 220 Raman spectra were recorded from 29 snap-frozen bladder samples collected at cystoscopic procedures, and 197 Raman spectra were recorded from 38 snap-frozen prostate samples collected at transurethral resection of the prostate.
  • The spectra were correlated with the histologic features and used to construct separate diagnostic algorithms for the bladder and prostate.
  • RESULTS: The bladder algorithm was able to differentiate benign samples (normal and cystitis) from malignant samples (transitional cell carcinoma), with an overall accuracy of 84%.
  • The prostate algorithm was able to differentiate benign samples (benign prostatic hyperplasia and prostatitis) from malignant samples (prostate cancer), with an overall accuracy of 86%.
  • CONCLUSIONS: The results of this study have demonstrated that the clinical Raman system can provide an accurate and objective method to diagnose prostate and bladder cancer in vitro.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Transitional Cell / diagnosis. Prostatic Neoplasms / diagnosis. Spectroscopy, Near-Infrared. Urinary Bladder Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Fiber Optic Technology. Humans. In Vitro Techniques. Male. Sensitivity and Specificity


93. Kountourakis P, Ardavanis A, Mantzaris I, Mitsaka D, Rigatos G: Urachal mucinous adenocarcinoma: a case report. J BUON; 2007 Oct-Dec;12(4):547-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Urachal mucinous adenocarcinoma: a case report.
  • Adenocarcinomas account for 0.5-2% of all bladder cancers.
  • Urachal carcinoma is a rare neoplasm which represents 0.01% of all cancers in adults and account for one third of bladder adenocarcinomas.
  • A 65-year-old white man with an urachal mucinous adenocarcinoma is reported.
  • None of the known predisposing risk factors for bladder cancer -such as tobacco use and professional exposure to chemicals -were identified in his past medical history.
  • The development of this rare neoplasm should not be clearly dissociated from multiple sclerosis, either aetiologically sharing an unidentified common causative factor or due to its treatment with mitoxantrone.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / surgery. Urachus. Urinary Bladder Neoplasms / diagnosis. Urinary Bladder Neoplasms / surgery

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  • (PMID = 18067216.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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94. Castellan M, Gosalbez R, Perez-Brayfield M, Healey P, McDonald R, Labbie A, Lendvay T: Tumor in bladder reservoir after gastrocystoplasty. J Urol; 2007 Oct;178(4 Pt 2):1771-4; discussion 1774
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tumor in bladder reservoir after gastrocystoplasty.
  • PURPOSE: To our knowledge the risk of malignancy in patients with previous bladder augmentation with stomach is unknown.
  • We report 3 cases of gastric adenocarcinoma and 1 of transitional cell carcinoma after augmentation cystoplasty with stomach with long-term followup.
  • Preoperative diagnosis was neurogenic bladder in 3 patients and posterior urethral valve in 1.
  • Three patients had gastric adenocarcinoma, while the other had poorly differentiated transitional cell carcinoma.
  • CONCLUSIONS: Patients who undergo bladder augmentation with a gastric remnant are at increased risk for malignancy, probably similar to that in patients with enterocystoplasty.
  • Patients should be followed annually with ultrasound, and cystoscopy should be performed annually starting 10 years after gastrocystoplasty unless they have abnormal ultrasound, hematuria or another cancer risk factor.
  • [MeSH-major] Adenocarcinoma / etiology. Carcinoma, Transitional Cell / etiology. Gastric Mucosa / transplantation. Urinary Bladder Neoplasms / etiology. Urinary Diversion / adverse effects. Urinary Reservoirs, Continent / adverse effects
  • [MeSH-minor] Adolescent. Adult. Child. Humans. Male. Retrospective Studies. Risk Factors. Urinary Bladder / surgery. Urodynamics

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  • (PMID = 17707009.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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95. Hodges KB, Lopez-Beltran A, Emerson RE, Montironi R, Cheng L: Clinical utility of immunohistochemistry in the diagnoses of urinary bladder neoplasia. Appl Immunohistochem Mol Morphol; 2010 Oct;18(5):401-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical utility of immunohistochemistry in the diagnoses of urinary bladder neoplasia.
  • Recent advances have identified a number of immunohistochemical stains that, when used in the context of a panel, can be a valuable tool in properly classifying primary urothelial carcinoma and carcinomas secondarily involving the urinary bladder.
  • In addition, new biomarkers prove helpful in the staging of bladder carcinoma.
  • In this article, we review the clinical utility of immunohistochemistry in a series of diagnostic scenarios, including flat urothelial lesions with atypia, rare variants of urothelial carcinoma, primary adenocarcinoma versus secondary colorectal tumors, distinguishing prostate from urothelial carcinoma, and the utility of smoothelin in staging bladder carcinoma.

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  • (PMID = 20505509.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cytoskeletal Proteins; 0 / Muscle Proteins; 0 / SMTN protein, human
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96. Matsuhashi N, Yamaguchi K, Tamura T, Shimokawa K, Sugiyama Y, Adachi Y: Adenocarcinoma in bladder diverticulum, metastatic from gastric cancer. World J Surg Oncol; 2005 Aug 24;3:55

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma in bladder diverticulum, metastatic from gastric cancer.
  • BACKGROUND: Metastasis to the urinary bladder from gastric cancer is rare.
  • Metastasis to a diverticulum of the bladder from gastric cancer is extremely rare.
  • We report a case of isolated bladder metastasis from gastric cancer and invasion localized to the muscularis propria of the primary site (stomach).
  • CASE PRESENTATION: A 90-year-old female presented with nausea and vomiting that was diagnosed as gastric cancer, the patient also had intermittent hematuria.
  • Pelvic computed tomography identified an abnormally thickened area in the bladder wall that was diagnosed as a diverticulum of the bladder.
  • A biopsy of the bladder wall revealed well differentiated tubular adenocarcinoma metastatic from gastric carcinoma.
  • CONCLUSION: Almost all cases of bladder metastasis from gastric cancer had peritoneal dissemination.
  • This particular presentation of bladder metastasis from gastric cancer, to the best of our knowledge, has not been previously reported.

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  • [Cites] Jpn J Clin Oncol. 1999 Jun;29(6):314-6 [10418562.001]
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  • (PMID = 16117837.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1208965
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97. Marlin ES, Hyams ES, Dulabon L, Shah O: Metastatic esophageal adenocarcinoma to the prostate presenting with bilateral ureteral obstruction. Can J Urol; 2010 Feb;17(1):5035-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic esophageal adenocarcinoma to the prostate presenting with bilateral ureteral obstruction.
  • Carcinoma metastatic to the prostate occurs rarely and is most commonly associated with malignant bladder neoplasms.
  • We present the case of a 73-year-old male with a history of gastroesophageal adenocarcinoma and clinically symptomatic benign prostatic hyperplasia who underwent photoselective vaporization of the prostate and presented several months later with gross hematuria, intermittent urinary retention and bilateral ureteral obstruction causing acute renal failure.
  • After relieving the ureteral obstruction, subsequent transurethral resection of the prostate revealed locally invasive metastatic esophageal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Esophageal Neoplasms / pathology. Prostatic Neoplasms / secondary. Ureteral Obstruction / etiology
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male. Neoplasm Invasiveness. Prostatic Hyperplasia / diagnosis. Prostatic Hyperplasia / surgery

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  • (PMID = 20156389.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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98. Colombo Jr JR, Desai M, Canes D, Frota R, Haber GP, Moinzadeh A, Tuerk I, Desai MR, Gill IS: Laparoscopic partial cystectomy for urachal and bladder cancer. Clinics (Sao Paulo); 2008 Dec;63(6):731-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic partial cystectomy for urachal and bladder cancer.
  • PURPOSE: To report our initial experiences with laparoscopic partial cystectomy for urachal and bladder malignancy.
  • MATERIALS AND METHODS: Between March 2002 and October 2004, laparoscopic partial cystectomy was performed in 6 cases at 3 institutions; 3 cases were urachal adenocarcinomas and the remaining 3 cases were bladder transitional cell carcinomas.
  • Gross hematuria was the presenting symptom in all patients, and diagnosis was established with trans-urethral resection bladder tumor in 2 patients and by means of cystoscopic biopsy in the remaining 4 patients.
  • Frozen section evaluations of bladder margins were routinely obtained and were negative for cancer in all cases.
  • Final histopathology confirmed urachal adenocarcinoma in 3 cases and bladder transitional cell carcinoma in 3 cases.
  • CONCLUSIONS: Laparoscopic partial cystectomy in carefully selected patients with urachal and bladder cancer is feasible and safe, offering a promising and minimally invasive alternative for these patients.
  • [MeSH-major] Adenocarcinoma / surgery. Carcinoma, Transitional Cell / surgery. Cystectomy / methods. Urachus / surgery. Urinary Bladder Neoplasms / surgery

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  • (PMID = 19060992.001).
  • [ISSN] 1980-5322
  • [Journal-full-title] Clinics (São Paulo, Brazil)
  • [ISO-abbreviation] Clinics (Sao Paulo)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
  • [Other-IDs] NLM/ PMC2664270
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99. Singh A, Kinoshita Y, Rovito PM Jr, Landas S, Silberstein J, Nsouli I, Wang CY, Haas GP: Higher than expected association of clinical prostate and bladder cancers. J Urol; 2005 May;173(5):1526-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Higher than expected association of clinical prostate and bladder cancers.
  • PURPOSE: In this study we evaluated the risk of a second malignancy of the bladder or prostate in patients with a previous diagnosis of prostate cancer (PCa) or urothelial cancer (TCC).
  • All patients with TCC presented with hematuria or irritative voiding symptoms and the diagnoses were confirmed with a tissue diagnosis.
  • Average age at PCa and TCC diagnosis +/- SD was 68.2 +/- 7.9 and 68.2 +/- 10.4 years, respectively.
  • SIR for lung, renal or colon cancer was not significantly different from what was expected.
  • CONCLUSIONS: Patients with PCa have higher incidence of bladder cancer and those with bladder cancer have a higher incidence of PCa.
  • [MeSH-major] Adenocarcinoma / epidemiology. Carcinoma, Transitional Cell / epidemiology. Neoplasms, Second Primary / epidemiology. Prostatic Neoplasms / epidemiology. Urinary Bladder Neoplasms / epidemiology

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  • [ReprintIn] J Urol. 2008 May;179(5 Suppl):S2-5 [18405742.001]
  • (PMID = 15821472.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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100. Farrell S, Gray SB, Best BG: Mucusuria--an unusual manifestation of ileal adenocarcinoma: a case report and review of the literature. Int Surg; 2005 Apr-Jun;90(2):85-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucusuria--an unusual manifestation of ileal adenocarcinoma: a case report and review of the literature.
  • Primary adenocarcinoma of the ileum is an uncommon gastrointestinal malignancy, the symptoms of which are often insidious in onset.
  • This case history highlights the previously unreported finding of ileal adenocarcinoma presenting with mucusuria, caused by local invasion of the bladder in a 44-year-old male.
  • A review of the literature is included to highlight the incidence, risk factors, clinical presentation, investigation, and current management of adenocarcinoma of the small bowel.
  • [MeSH-major] Adenocarcinoma / secondary. Ileal Neoplasms / pathology. Intestinal Fistula / diagnosis. Urinary Bladder Fistula / diagnosis. Urinary Bladder Neoplasms / secondary

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  • (PMID = 16119711.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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