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1. Hansel DE, Nadasdy T, Epstein JI: Fibromyxoid nephrogenic adenoma: a newly recognized variant mimicking mucinous adenocarcinoma. Am J Surg Pathol; 2007 Aug;31(8):1231-7
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  • [Title] Fibromyxoid nephrogenic adenoma: a newly recognized variant mimicking mucinous adenocarcinoma.
  • All 8 patients were elderly men who had a prior or concurrent history of acinar prostate cancer (n=4), combined acinar prostate and urothelial carcinoma (n=1), urothelial-type adenocarcinoma of the prostate (n=1), bladder urothelial carcinoma (n=1), or no prior reported prostatic or urothelial abnormalities (n=1).
  • Awareness of this entity and the use of ancillary techniques can aid in the diagnosis of this unusual form of nephrogenic adenoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Adenoma / pathology. Fibroma / pathology. Urologic Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Male. Middle Aged. Mucins / analysis. Neoplasms, Multiple Primary. Urothelium / chemistry. Urothelium / pathology

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  • (PMID = 17667548.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins
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2. Ballesteros Sampol JJ, Lloreta Trull J, Ballesteros Monzó C, Jaramillo Velásquez R: [Report of two cases of bladder and prostate oat cell tumors]. Arch Esp Urol; 2005 Mar;58(2):170-5
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  • [Title] [Report of two cases of bladder and prostate oat cell tumors].
  • [Transliterated title] "Presentación de dos casos: vesical y prostático de oat-cell".
  • OBJECTIVES: To report two cases of bladder and prostate oat cell tumors with bad outcome, in accordance to the bibliographic review.
  • METHODS: The case in the bladder was associated with squamous differentiation and adenocarcinoma.
  • Radical treatment followed by adjuvant chemotherapy did not stop the fatal outcome which ended 13 months later in acute septicemia having developed multiple metastases.
  • Once diagnosis was achieved the extemal urinary diversion was converted to intemal to improve patient's comfort.
  • There was no response to systemic chemotherapy and the patient died 4 months after diagnosis.
  • In our country, 15 cases have been confirmed in the bladder and 5 in the prostate; around the world, 150 and 59 respectively.
  • Although there is a certain tendency to think that radical treatment and chemotherapy is the least bad of the options, some consequences of conservative attitudes offer similar results, mainly when preserving the bladder.
  • [MeSH-major] Carcinoma, Small Cell. Prostatic Neoplasms. Urinary Bladder Neoplasms

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  • (PMID = 15847277.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 15
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3. Shigehara K, Taya T, Hisazumi H: Primary adenocarcinoma in the bladder diverticulum. Scand J Urol Nephrol; 2008;42(5):481-3
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  • [Title] Primary adenocarcinoma in the bladder diverticulum.
  • Cystoscopy revealed a papillary tumor within the diverticulum of the bladder.
  • A transurethral resection was performed and histopathological examination revealed adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Diverticulum / pathology. Urinary Bladder Diseases / pathology. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy. Cystectomy. Cystoscopy. Diagnosis, Differential. Hematuria / etiology. Humans. Male. Tomography, X-Ray Computed. Urinary Bladder / pathology

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  • (PMID = 18792856.001).
  • [ISSN] 0036-5599
  • [Journal-full-title] Scandinavian journal of urology and nephrology
  • [ISO-abbreviation] Scand. J. Urol. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
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4. Kwiatkowski M, Paśnik K, Orłowski M, Furga P: [Therapeutic and diagnostic problems in a patient with a pelvic tumour--case report]. Pol Merkur Lekarski; 2009 May;26(155):496-9
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  • Colorectal cancer has become the commonest form of cancer in gastrointestinal (GI) tract and nowadays it is the second cause of death among all malignant tumours.
  • Bladder cancer is the fourth commonest tumour in males and eighth in females.
  • Despite repeated colon and bladder biopsies no malignancy was found.
  • The results of imaging investigations suggested a bladder-derived tumour (from a bladder diverticulum or persisting urachus).
  • The diagnosis confirmed in histological examination was adenocarcinoma of the colon.
  • The article presents successive stages of diagnosis and therapy.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Colonic Neoplasms / diagnosis. Colonic Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy. Diagnosis, Differential. Humans. Male. Urinary Bladder Neoplasms / diagnosis

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  • (PMID = 19606709.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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5. Zizi-Sermpetzoglou A, Savvaidou V, Tepelenis N, Galariotis N, Olympitis M, Stamatiou K: Sarcomatoid carcinoma of the prostate: a case report. Int J Clin Exp Pathol; 2010;3(3):319-22
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  • Sarcomatoid carcinoma of the prostate is a rare variant of prostatic cancer, with less than 100 cases reported in the literature up to date.
  • We report a case of a 76-year old Caucasian man who underwent transurethral resection of the prostate for the treatment of bladder outlet obstruction.
  • The malignant epithelial component consisted of poorly differentiated adenocarcinoma (Gleason score 5+4=9/10) and the sarcomatous component was mainly composed of undifferentiated spindle cells.
  • The diagnosis of sarcomatoid carcinoma was finally made.
  • Although sarcomatoid carcinoma of the prostate is a highly aggressive neoplasm and patients have a poor prognosis, our patient is still alive one year after diagnosis.
  • [MeSH-major] Prostatic Neoplasms / diagnosis. Sarcoma / diagnosis

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  • [Cites] Pathol Res Pract. 2000;196(8):569-72 [10982020.001]
  • [Cites] Mod Pathol. 2004 Mar;17(3):316-27 [14976541.001]
  • [Cites] Am J Surg Pathol. 1988 May;12(5):379-89 [3284397.001]
  • [Cites] BJU Int. 2008 Nov;102(10):1369-74 [18793296.001]
  • [Cites] Urology. 2006 Feb;67(2):423.e5-423.e8 [16461109.001]
  • [Cites] Am J Surg Pathol. 2006 Oct;30(10):1316-21 [17001164.001]
  • [Cites] J Urol. 2005 Feb;173(2):439-40 [15643196.001]
  • (PMID = 20224731.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vimentin
  • [Other-IDs] NLM/ PMC2836510
  • [Keywords] NOTNLM ; Prostate cancer / carcinosarcoma / cytokeratin AE1/3 / immunohistochemistry / sarcomatoid carcinoma / vimentin
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6. Haddad FS: Secondary adenocarcinomas of the urinary bladder. J Med Liban; 2008 Jan-Mar;56(1):48
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  • [Title] Secondary adenocarcinomas of the urinary bladder.
  • [MeSH-major] Adenocarcinoma / secondary. Prostatic Neoplasms / pathology. Stomach Neoplasms / pathology. Urinary Bladder Neoplasms / secondary
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Urinary Bladder / pathology

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  • [CommentOn] J Med Liban. 2007 Jul-Sep;55(3):162-4 [17966739.001]
  • (PMID = 19534093.001).
  • [ISSN] 0023-9852
  • [Journal-full-title] Le Journal médical libanais. The Lebanese medical journal
  • [ISO-abbreviation] J Med Liban
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] Lebanon
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7. Kawamura N, Hatano K, Kakuta Y, Takada T, Hara T, Yamaguchi S: [A case of hepatoid adenocarcinoma of the urinary bladder]. Hinyokika Kiyo; 2009 Oct;55(10):619-22
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  • [Title] [A case of hepatoid adenocarcinoma of the urinary bladder].
  • He was diagnosed as having bladder tumors and bladder stone by cystoscopy.
  • Transurethral resection of bladder tumors (TURBT) and transurethral cystolithotripsy were performed and histology revealed non-muscle-invasive hepatoid adenocarcinoma that produced alpha-fetoprotein (AFP) and urothelial carcinoma.
  • After five months' follow up, recurrent tumor were detected in the bladder.
  • TURBT was performed and the pathologic finding showed non-muscle-invasive (not hepatoid) adenocarcinoma that produced AFP.
  • After eight months' follow up, a recurrent tumor was detected in the bladder again.
  • [MeSH-major] Adenocarcinoma / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 19926947.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
  • [Number-of-references] 8
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8. Zhang X, Gupta R, Nicastri AD: Bladder adenocarcinoma following gastrocystoplasty. J Pediatr Urol; 2010 Oct;6(5):525-7
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  • [Title] Bladder adenocarcinoma following gastrocystoplasty.
  • Bladder augmentation with segments of small bowel (ileocystoplasty), large intestine (colocystoplasty) or stomach (gastrocystoplasty) has been used to treat patients with small or noncompliant bladders by increasing the capacity or compliance.
  • Carcinomas following gastrocystoplasty have been observed in the segments of stomach; however, to our knowledge, carcinoma arising in the residual native bladder has not been reported.
  • We report the first case of adenocarcinoma arising in the residual native bladder in association with intestinal metaplasia and dysplasia of bladder mucosa 17 years following gastrocystoplasty.
  • Intestinal metaplasia secondary to recurrent urinary infection, chronic inflammation, and some form of irritation may potentiate the development of native bladder adenocarcinoma.
  • Patients with gastrocystoplasty are at an increased risk for carcinoma in stomach segments and require close long-term follow up; however, the risk of carcinoma in native bladder is still unclear.
  • [MeSH-major] Adenocarcinoma / etiology. Urinary Bladder / surgery. Urinary Bladder Neoplasms / etiology. Urologic Surgical Procedures / adverse effects

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  • [Copyright] Copyright © 2010 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20392671.001).
  • [ISSN] 1873-4898
  • [Journal-full-title] Journal of pediatric urology
  • [ISO-abbreviation] J Pediatr Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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9. Parekh DJ, Lin WC, Herrell SD: Optical spectroscopy characteristics can differentiate benign and malignant renal tissues: a potentially useful modality. J Urol; 2005 Nov;174(5):1754-8
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  • PURPOSE: Promising results of optical signals have been reported in the literature for the diagnosis of Barrett's esophagus, oral cavity lesions, brain tumor margins, cervical intraepithelial neoplasia, skin cancer and bladder cancer.
  • The potential usefulness of these techniques in renal tissues and neoplasms has not been described to date.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Precancerous Conditions / pathology. Spectrometry, Fluorescence
  • [MeSH-minor] Case-Control Studies. Diagnosis, Differential. Female. Humans. Kidney / pathology. Male. Reference Values. Sampling Studies. Sensitivity and Specificity. Tissue Culture Techniques

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  • [CommentIn] J Urol. 2005 Nov;174(5):1723-4 [16217270.001]
  • (PMID = 16217277.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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10. Suzuki T, Togo Y, Yasuda K, Yamamoto H, Kokura K, Nagareda T: [Prostatic duct adenocarcinoma with pagetoid spread on the glans penis: a case report]. Hinyokika Kiyo; 2006 Nov;52(11):887-90
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  • [Title] [Prostatic duct adenocarcinoma with pagetoid spread on the glans penis: a case report].
  • The patient underwent total cystoprostatectomy under the diagnosis of urothelial carcinoma of the urinary bladder four years earlier.
  • At the time, the prostatectomy specimen incidentally revealed a prostatic acinar adenocarcinoma at the bilateral peripheral zone.
  • A skin biopsy of the erythema revealed intraepithelial Paget's cells, and the patient underwent total penectomy under the diagnosis of extramammary Paget's disease.
  • Re-examination of the previous prostatectomy specimen revealed prostatic duct adenocarcinoma with prostatic acinar adenocarcinoma.
  • Therefore, the final diagnosis was prostatic duct adenocarcinoma with Pagetoid spread to the glans penis.
  • [MeSH-major] Adenocarcinoma / pathology. Paget Disease, Extramammary / pathology. Penile Neoplasms / pathology. Prostatic Neoplasms / pathology
  • [MeSH-minor] Aged. Carcinoma / pathology. Humans. Male. Neoplasms, Multiple Primary / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 17176876.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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11. Rouache L, Cherif M, Tanneau Y, Gobet F, Pfister C: [Secondary appearance of a carcinoma in an excluded native bladder: Report of three cases]. Prog Urol; 2006 Nov;16(5):603-6
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  • [Title] [Secondary appearance of a carcinoma in an excluded native bladder: Report of three cases].
  • [Transliterated title] Apparition secondaire d'un carcinome sur vessie native exclue: à propos de trois cas.
  • INTRODUCTION: The management of congenital urological malformations is sometimes complex and may require urinary diversion.
  • Cystectomy is usually performed, but sometimes the bladder is left in place due to the presence of a pelvic cloaca and the morbidity related to this type of surgery.
  • MATERIAL: The authors report three cases of patients treated by urinary diversion for a congenital malformation without primary resection of the bladder RESULTS: In the absence of any infectious complications, bladder carcinoma on an excluded native bladder was diagnosed at the age of 3 years, 4 years and 38 years, respectively.
  • Histological examination showed transitional cell carcinoma in two cases and gastrointestinal-type adenocarcinoma of the bladder in 1 case.
  • CONCLUSION: The risk of secondary development of carcinoma in an excluded bladder during management of (congenital urological malformations is not negligible.
  • The authors also recommend cystoscopy and urine cytology with lavage to detect degeneration of the bladder mucosa.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Transitional Cell / diagnosis. Urinary Bladder / abnormalities. Urinary Bladder Neoplasms / diagnosis
  • [MeSH-minor] Adult. Humans. Male. Middle Aged. Urinary Diversion

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  • (PMID = 17175961.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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12. Abol-Enein H, Kava BR, Carmack AJ: Nonurothelial cancer of the bladder. Urology; 2007 Jan;69(1 Suppl):93-104
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  • [Title] Nonurothelial cancer of the bladder.
  • In this article, we review available evidence on the treatment of patients with nonurothelial cancer of the bladder.
  • Squamous cell carcinoma and adenocarcinoma are ideally treated with radical cystectomy.
  • Other rarer tumors of the bladder are also discussed.
  • [MeSH-major] Carcinoma, Squamous Cell. Urinary Bladder Neoplasms
  • [MeSH-minor] Combined Modality Therapy. Diagnosis, Differential. Global Health. Humans. Survival Rate

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  • (PMID = 17280911.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 119
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13. Chen ZF, Wang F, Qin ZK, Dai YP, Zhou FJ, Han H, Liu ZW, Yu SL, Li YH, Ye YL: [Clinical analysis of 14 cases of urachal carcinoma]. Ai Zheng; 2008 Sep;27(9):966-9
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  • This study was to summarize our clinical experience in the diagnosis and treatment of urachal carcinoma.
  • METHODS: Fourteen cases of urachal carcinoma treated from May 1994 to April 2007 at Cancer Center and The First Affiliated Hospital of Sun Yat-sen University were retrospectively reviewed and analyzed.
  • RESULTS: The most common complaints of the 14 patients were hematuria and irrigative bladder symptoms.
  • Cystoscopy mainly revealed broad-based tumors located at the dome of the bladder.
  • Soft-tissue masses between the bladder dome and the abdominal wall were detected by imaging examinations; the wall of the bladder was often invaded.
  • Thirteen patients were found adenocarcinoma, the other one was malignant stromal cell tumor.
  • Seven patients underwent extensive partial excision of the bladder, among which one case developed local recurrence 24 months after operation, while the other six cases were followed up for 14-120 months, with a median follow-up of 42 months without recurrence.
  • Three patients underwent radical bladder resection and urinary diversion, two of which were followed up for 16 months and 84 months respectively without recurrence, while the other one died from surgical complications 3 months after operation.
  • Three advanced cancer patients received chemotherapy, two of which achieved progression free survival for seven and eight months respectively, while the other one died three months after chemotherapy.
  • CONCLUSIONS: Extensive partial excision of the bladder is recommended for urachal carcinoma.
  • Radical removal of the tumor during the first treatment and comprehensive therapies for advanced cancer patients and patients with recurrence or metastasis after operation are critical to improve the treatment efficacy of urachal carcinoma.
  • [MeSH-major] Adenocarcinoma / surgery. Cystectomy / methods. Urachus / pathology. Urinary Bladder Neoplasms / surgery

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  • (PMID = 18799037.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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14. Shintaku WH, Venturin JS, Yepes JF: Application of advanced imaging modalities for the diagnosis of metastatic adenocarcinoma of the lungs in the temporomandibular joint. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Jun;107(6):e37-41
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  • [Title] Application of advanced imaging modalities for the diagnosis of metastatic adenocarcinoma of the lungs in the temporomandibular joint.
  • Correct diagnosis is important to avoid treatment delay.
  • Positron emission tomography showed significant radiotracer uptake in the site of the lesion as well as in the lungs, lumbar spine, and bladder, suggesting tumoral metastases.
  • This report emphasizes the importance of imaging in the assessment and establishment of accurate differential diagnosis.
  • [MeSH-major] Adenocarcinoma / secondary. Lung Neoplasms / pathology. Mandibular Neoplasms / secondary. Temporomandibular Joint / pathology. Temporomandibular Joint Disorders / radiography

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  • (PMID = 19464641.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Mai KT, Nguyen B: Urothelial carcinoma and prostatic adenocarcinoma presenting as collision tumors. Can J Urol; 2009 Oct;16(5):4850-3
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  • [Title] Urothelial carcinoma and prostatic adenocarcinoma presenting as collision tumors.
  • Urothelial carcinoma (UC) and prostatic adenocarcinoma (PAC) commonly occur in elderly patients and share common carcinogenic factors that could be identified in the urine.
  • Simultaneous occurrence of PAC and UC in the prostate is not uncommon; however, urinary bladder location of both lesions has not yet been reported.
  • Furthermore, invasion into the urinary bladder wall by a PAC can also pose a diagnostic challenge with UC and other primary urinary bladder tumors.
  • We report three patients presenting with UC and PAC within the urinary bladder.
  • All patients were diagnosed with high grade PAC and either had simultaneous at the initial diagnosis or developed UC during the follow up for PAC.
  • In conclusion, awareness of this association is important in making the correct diagnosis, especially when dealing with urinary bladder biopsy material.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Neoplasms, Multiple Primary. Prostatic Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Biopsy. Combined Modality Therapy. Cystoscopy. Diagnosis, Differential. Fatal Outcome. Humans. Male


16. Rau AR, Kini H, Pai RR: Morphological evaluation of cystitis glandularis. Indian J Pathol Microbiol; 2009 Apr-Jun;52(2):203-5
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  • Cystitis cystica and cystitis glandularis (CG) are relatively common appearances in the urinary bladder though CG may occasionally mimic a neoplasm.
  • This study was undertaken to study the morphology of CG and to highlight the differences in morphology between CG and adenocarcinoma.
  • One case of primary adenocarcinoma was included in this study, where the adjacent bladder mucosa showed CG.
  • Evaluation of the histological features of CG, especially intestinal type helps in correct categorization of this lesion and differentiation from adenocarcinoma of the bladder.
  • [MeSH-major] Cystitis / pathology. Urinary Bladder / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged, 80 and over. Child. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Urinary Bladder Neoplasms / pathology

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  • (PMID = 19332913.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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17. McKenney JK, Amin MB: The role of immunohistochemistry in the diagnosis of urinary bladder neoplasms. Semin Diagn Pathol; 2005 Feb;22(1):69-87
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The role of immunohistochemistry in the diagnosis of urinary bladder neoplasms.
  • The spectrum of neoplasms involving the urinary bladder is diverse, and, at times, different entities with distinct prognostic and managerial implications may have significant morphologic overlap.
  • The presence of a neoplasm with an unusual morphologic appearance, such as an undifferentiated spindled, or plasmacytoid pattern may necessitate immunohistochemistry to establish the diagnosis.
  • In this review, we discuss a series of distinct diagnostic scenarios, including high-grade undifferentiated carcinoma versus prostatic adenocarcinoma, enteric-type adenocarcinoma versus secondary colorectal adenocarcinoma, spindle cell proliferations, neoplasms with plasmacytoid morphology, endophytic tumors with a nested growth pattern, and flat urothelial lesions with atypia.
  • The importance of using a morphologically derived differential diagnosis to guide the selection and interpretation of immunohistochemical studies is emphasized, and the varying utility (specificity) of the individual immunohistochemical markers within each setting is addressed.
  • [MeSH-major] Immunohistochemistry. Urinary Bladder Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adult. Biomarkers, Tumor / analysis. Carcinoma / diagnosis. Carcinoma / pathology. Child. Diagnosis, Differential. Humans. Male. Neoplasm Metastasis. Neoplasms, Unknown Primary / diagnosis. Precancerous Conditions. Prostatic Neoplasms / pathology

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  • (PMID = 16512600.001).
  • [ISSN] 0740-2570
  • [Journal-full-title] Seminars in diagnostic pathology
  • [ISO-abbreviation] Semin Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 62
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18. Mukenge S, Pulitanò C, Colombo R, Negrini D, Ferla G: Secondary scrotal lymphedema: a novel microsurgical approach. Microsurgery; 2007;27(8):655-6
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  • We report a case of secondary lymphedema of male genitalia presenting more than 4 years after a radical cystectomy with extended pelvic lymphadenectomy for adenocarcinoma of the bladder.
  • [MeSH-major] Cystectomy / adverse effects. Lymphedema / surgery. Microsurgery / methods. Scrotum / surgery. Urinary Bladder Neoplasms / surgery

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  • (PMID = 17929261.001).
  • [ISSN] 0738-1085
  • [Journal-full-title] Microsurgery
  • [ISO-abbreviation] Microsurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. International Bladder Cancer Nomogram Consortium, Bochner BH, Kattan MW, Vora KC: Postoperative nomogram predicting risk of recurrence after radical cystectomy for bladder cancer. J Clin Oncol; 2006 Aug 20;24(24):3967-72
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  • [Title] Postoperative nomogram predicting risk of recurrence after radical cystectomy for bladder cancer.
  • PURPOSE: Radical cystectomy and pelvic lymphadenectomy (PLND) remains the standard treatment for localized and regionally advanced invasive bladder cancers.
  • We have constructed an international bladder cancer database from centers of excellence in the management of bladder cancer consisting of patients treated with radical cystectomy and PLND.
  • PATIENTS AND METHODS: Institutional radical cystectomy databases containing detailed information on bladder cancer patients were obtained from 12 centers of excellence worldwide.
  • RESULTS: The final nomogram included information on patient age, sex, time from diagnosis to surgery, pathologic tumor stage and grade, tumor histologic subtype, and regional lymph node status.
  • The predictive accuracy of the constructed international nomogram (concordance index, 0.75) was significantly better than standard American Joint Committee on Cancer TNM (concordance index, 0.68; P < .001) or standard pathologic subgroupings (concordance index, 0.62; P < .001).
  • CONCLUSION: We have developed an international bladder cancer nomogram predicting recurrence risk after radical cystectomy for bladder cancer.
  • The nomogram outperformed prognostic models that use standard pathologic subgroupings and should improve our ability to provide accurate risk assessments to patients after the surgical management of bladder cancer.
  • [MeSH-major] Adenocarcinoma / secondary. Carcinoma, Squamous Cell / secondary. Carcinoma, Transitional Cell / secondary. Cystectomy. Nomograms. Urinary Bladder Neoplasms / pathology

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  • [CommentIn] J Clin Oncol. 2006 Aug 20;24(24):3819-20 [16864852.001]
  • [ErratumIn] J Clin Oncol. 2007 Apr 10;25(11):1457
  • (PMID = 16864855.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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20. Nimmonrat A, Na-ChiangMai W, Muttarak M: Urachal abnormalities: clinical and imaging features. Singapore Med J; 2008 Nov;49(11):930-5
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  • CT in all cases showed a mass located extraperitoneally in the midline just beneath the rectus abdominis muscle and extending from the umbilicus to the dome of the urinary bladder.
  • Cystography was performed in one patient and it showed indentation to the dome of the urinary bladder with mucosal irregularity.
  • The other five solid masses were found to be adenocarcinoma in three and chronic non-specific inflammation in two cases.
  • CONCLUSION: Preoperative diagnosis of urachal abnormalities may be suggested by clinical presentation and imaging features.
  • [MeSH-major] Adenocarcinoma / diagnosis. Neoplasms / diagnosis. Urachal Cyst / diagnosis. Urachus / abnormalities
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome. Urologic Diseases / complications. Urologic Diseases / diagnosis. Urologic Diseases / pathology

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  • (PMID = 19037562.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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21. Shiwani MH: Surgical management of gall bladder carcinoma. J Pak Med Assoc; 2007 Feb;57(2):87-91
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  • [Title] Surgical management of gall bladder carcinoma.
  • CaGB is a rare form of cancer and its association with gallstone disease should be recognised.
  • Although overall prognosis is poor, early diagnosis of CaGB and radical surgery provides better outcome.
  • [MeSH-major] Adenocarcinoma / surgery. Gallbladder Neoplasms / surgery

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  • (PMID = 17370792.001).
  • [ISSN] 0030-9982
  • [Journal-full-title] JPMA. The Journal of the Pakistan Medical Association
  • [ISO-abbreviation] J Pak Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Pakistan
  • [Number-of-references] 17
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22. Shinohara T, Misawa K, Sano H, Okawa Y, Takada A: Pseudomyxoma peritonei due to mucinous cystadenocarcinoma in situ of the urachus presenting as an inguinal hernia. Int J Clin Oncol; 2006 Oct;11(5):416-9
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  • During herniorrhaphy, we found a large amount of gelatinous mucinous material in the indirect-hernia sac and made a diagnosis of pseudomyxoma peritonei on cytological grounds.
  • The urachal cyst and the dome of the urinary bladder were excised.
  • On histological examination, a unilocular cyst was found to consist of noninvasive mucinous adenocarcinoma.
  • [MeSH-major] Cystadenocarcinoma, Mucinous / diagnosis. Hernia, Inguinal / etiology. Neoplasms, Multiple Primary. Peritoneal Neoplasms / diagnosis. Pseudomyxoma Peritonei / diagnosis. Urachus

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  • (PMID = 17058142.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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23. Shukla PJ, Barreto SG, Shrikhande SV, Mohandas KM, Purandare N, Rangarajan V: Detection of gall bladder cancer metastases in rare sites by PET scan. Indian J Gastroenterol; 2007 Nov-Dec;26(6):303-4
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  • [Title] Detection of gall bladder cancer metastases in rare sites by PET scan.
  • [MeSH-major] Adenocarcinoma / radionuclide imaging. Adenocarcinoma / secondary. Breast Neoplasms / radionuclide imaging. Breast Neoplasms / secondary. Gallbladder Neoplasms / pathology. Tomography, Emission-Computed
  • [MeSH-minor] Diagnosis, Differential. Female. Fluorodeoxyglucose F18. Humans. Lymphatic Metastasis / radionuclide imaging. Middle Aged. Neoplasm Metastasis. Radiopharmaceuticals

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  • (PMID = 18431025.001).
  • [ISSN] 0254-8860
  • [Journal-full-title] Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
  • [ISO-abbreviation] Indian J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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24. Zangrilli A, Saraceno R, Sarmati L, Orlandi A, Bianchi L, Chimenti S: Erysipeloid cutaneous metastasis from bladder carcinoma. Eur J Dermatol; 2007 Nov-Dec;17(6):534-6
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  • [Title] Erysipeloid cutaneous metastasis from bladder carcinoma.
  • Cutaneous metastases from bladder cancer are uncommon, especially in the female population.
  • We describe a 56-year-old female with a history of bladder adenocarcinoma (T3N0M0) who presented erythematous plaques with an erysipelas-like appearance located on the groins and thighs.
  • Histopathology and immunohistochemistry from skin lesions were consistent with metastases from bladder carcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Skin Neoplasms / secondary. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Erysipelas / diagnosis. Female. Humans. Immunohistochemistry. Middle Aged

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  • (PMID = 17951136.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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25. Herawi M, Drew PA, Pan CC, Epstein JI: Clear cell adenocarcinoma of the bladder and urethra: cases diffusely mimicking nephrogenic adenoma. Hum Pathol; 2010 Apr;41(4):594-601
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  • [Title] Clear cell adenocarcinoma of the bladder and urethra: cases diffusely mimicking nephrogenic adenoma.
  • Although clear cell adenocarcinoma have been described focally mimicking nephrogenic adenoma, we have identified a subset of clear cell adenocarcinoma that diffusely resembles nephrogenic adenoma (nephrogenic adenoma-like clear cell adenocarcinoma).
  • Twelve classic clear cell adenocarcinomas of the bladder and urethra and 7 nephrogenic adenoma-like clear cell adenocarcinomas were compared to 10 nephrogenic adenomas.
  • Classic clear cell adenocarcinoma was associated with urothelial carcinoma (n = 2) and endometriosis (n = 1).
  • The following antibodies were not helpful in distinguishing nephrogenic adenoma-like clear cell adenocarcinoma from nephrogenic adenoma: CD10, estrogen receptor, p63, high-molecular-weight cytokeratin, and alpha-methylacyl coenzyme-A racemase.
  • PAX2 expression was more frequent in nephrogenic adenoma (89%) compared to both patterns of clear cell adenocarcinoma (29%-32%).
  • The key features discriminating between nephrogenic adenoma-like clear cell adenocarcinoma and nephrogenic adenoma include occasional clear cells, more prominent pleomorphism especially hyperchromatic enlarged nuclei, and extensive muscular invasion.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Adenoma / diagnosis. Urethral Neoplasms / diagnosis. Urinary Bladder Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Urothelium / pathology

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  • [Copyright] Copyright 2010 Elsevier Inc.
  • (PMID = 20060152.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Tu WH, Jensen K, Freiha F, Liao JC: A case of prostatic adenocarcinoma recurrence presenting as ductal carcinoma of the prostate. Nat Clin Pract Urol; 2008 Jan;5(1):55-8
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  • [Title] A case of prostatic adenocarcinoma recurrence presenting as ductal carcinoma of the prostate.
  • BACKGROUND: A 61-year-old man with a history of recurrent prostate cancer presented with obstructive urinary symptoms.
  • He had been diagnosed with locally invasive adenocarcinoma of the prostate 10 years previously and treated with neoadjuvant hormonal and external beam radiation therapies.
  • Because of the patient's rising PSA level, he had been started on goserelin 6 years after this diagnosis and bicalutamide 6 months before the current presentation.
  • The patient presented to the urology clinic with worsening lower urinary tract symptoms consisting of nocturia, urgency, and weak stream.
  • Laboratory tests showed no evidence of urinary tract infection, but confirmed a rising PSA level despite low serum testosterone levels.
  • Cystoscopic examination revealed hypervascular, large lateral prostatic lobes obstructing the bladder neck.
  • The bladder was normal.
  • DIAGNOSIS: The patient underwent transurethral resection of the prostate.
  • Owing to the diffuse nature of the papillary tumors, complete resection was not possible.
  • The patient was started on docetaxel-based chemotherapy for hormone refractory recurrence of prostate cancer as ductal carcinoma of the prostate.
  • [MeSH-major] Carcinoma, Ductal / diagnosis. Neoplasm Recurrence, Local. Prostatic Neoplasms / diagnosis

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  • (PMID = 18185514.001).
  • [ISSN] 1743-4289
  • [Journal-full-title] Nature clinical practice. Urology
  • [ISO-abbreviation] Nat Clin Pract Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Bollito ER, Pacchioni D, Lopez-Beltran A, Volante M, Terrone C, Casetta G, Mari M, DePompa R, Cappia S, Papotti M: Immunohistochemical study of neuroendocrine differentiation in primary glandular lesions and tumors of the urinary bladder. Anal Quant Cytol Histol; 2005 Aug;27(4):218-24
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  • [Title] Immunohistochemical study of neuroendocrine differentiation in primary glandular lesions and tumors of the urinary bladder.
  • OBJECTIVE: Neuroendocrine (NE) cells are uncommon in primary adenocarcinoma (AC) and other glandular lesions of the bladder, with no recent study series concerning its significance in differential diagnosis, prognosis or biologic significance.
  • STUDY DESIGN: Sixteen primary bladder AC (enteric-type [n = 71, mucinous [n = 6] and not otherwise specified [NOS] [n = 31), 4 cases of urothelial carcinoma with glandular differentiation, 20 cases of glandular cystitis and 3 urachal remnants with intestinal metaplasia constituted the study series.
  • RESULTS: Chromogranin A-positive cells were present in 60% (11 of 16) of primary AC, all of enteric or mucinous type, but not in any of the 3 NOS-type AC investigated.
  • NE differentiation in bladder AC subtypes resulted in highly significant differences between enteric or mucinous vs. NOS type (p = 0.0023).
  • NE differentiation was also different in urachal vs. nonurachal AC (p = 0.020) and primary bladder AC vs. conventional invasive urothelial carcinoma (p < 0.001).
  • Synaptophysin-positive cells were seen in 2 (12.5%) of the 16 primary AC cases, and NSE was negative in the 16 primary bladder AC.
  • One of 4 urothelial carcinomas with glandular differentiation had chromogranin A-immunoreactive cells, but this was not significant when compared with primary AC (p = 0.1).
  • Normal-looking bladder urothelium and conventional urothelial carcinoma specimens had no chromogranin A-immunoreactive cells.
  • No correlation was found between NE differentiation and outcome of primary bladder AC or urothelial carcinoma with glandular differentiation.
  • CONCLUSION: Primary bladder AC, cystitis glandularis and urachal remnants with intestinal metaplasia showed variable degrees of NE differentiation, with no apparent clinical correlation or prognostic significance.
  • However, the absence of NE differentiation in NOS-type primary bladder AC may help in better defining this uncommon subtype of primary bladder AC.

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  • (PMID = 16220833.001).
  • [ISSN] 0884-6812
  • [Journal-full-title] Analytical and quantitative cytology and histology
  • [ISO-abbreviation] Anal. Quant. Cytol. Histol.
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chromogranin A; 0 / Chromogranins; 0 / Synaptophysin; EC 4.2.1.11 / Phosphopyruvate Hydratase
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28. Hameed O, Humphrey PA: Immunohistochemistry in diagnostic surgical pathology of the prostate. Semin Diagn Pathol; 2005 Feb;22(1):88-104
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  • Basal cell markers, such as the 34betaE12 antibody and antibodies directed against cytokeratin 5 and 6 or p63, are very useful for demonstration of basal cells as their presence argues against a diagnosis of invasive prostatic carcinoma (PC).
  • However, several benign mimickers of PC, including atrophy, atypical adenomatous hyperplasia (AAH), nephrogenic adenoma, and mesonephric hyperplasia, can stain negatively with these markers, and thus, a negative basal cell marker immunostain alone does not exclude a diagnosis of benignancy.
  • Alpha-methylacyl-coenzyme-A racemase (AMACR) is a sensitive marker of PC (except for a few uncommon variants: atrophic, foamy gland, and pseudohyperplastic variants), and its detection by immunohistochemical staining in atypical prostatic lesions can be very useful in confirming an impression of adenocarcinoma.
  • AMACR expression can also be identified in high grade prostatic intraepithelial neoplasia (PIN), prostatic atrophy, AAH, and benign prostatic glands, and accordingly, a diagnosis of PC should not be based solely on a positive AMACR immunostain, especially when the luminal staining is weak and/or noncircumferential.
  • Prostate specific antigen (PSA) and prostate specific acid phosphatase (PSAP) are both quite sensitive and fairly specific markers of PC (there are a few nonprostatic tumors that can express one or both), and are both very helpful in establishing or confirming the diagnosis of PC when the differential diagnosis includes other tumors that can involve the prostate such as urinary bladder urothelial carcinoma.
  • 34betaE12, p63, thrombomodulin, and uroplakin III are additional urothelial associated markers useful in this differential diagnosis.
  • CDX2 and villin are useful markers to diagnostically separate colonic adenocarcinoma from PC.
  • PSA and PSAP immunohistochemical stains are valuable in confirming metastatic carcinoma as being of prostatic origin and should always be utilized in the diagnostic evaluation of metastatic adenocarcinoma of unknown primary origin in males.
  • [MeSH-major] Carcinoma / diagnosis. Immunohistochemistry. Prostatic Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Carcinoma, Small Cell / diagnosis. Carcinoma, Small Cell / pathology. Diagnosis, Differential. Humans. Leukemia / diagnosis. Lymphoma / diagnosis. Male. Neoplasm Metastasis. Sarcoma / diagnosis. Sensitivity and Specificity. Urinary Bladder Neoplasms / diagnosis


29. Simon SK, Bolanca IK, Sentija K, Kukura V, Valetić J, Skrtić A: Vulvar Paget's disease--a case report. Coll Antropol; 2010 Jun;34(2):649-52
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  • Vulvar Morbus Paget (MP) represents a rare intraepithelial adenocarcinoma.
  • Occasionally, single anaplastic Paget's cells can be found on the vulvar smears which make cytological diagnosis of the disease possible.
  • Accordingly, cytological diagnosis vulvar intraepithelial neoplasia (VIN III) with differential diagnosis of vulvar Paget's disease was made.
  • The pathological verification supported the diagnosis of MP and an immunohistochemistry panel confirmed type III of Paget's disease and an evaluation of bladder was suggested.

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  • (PMID = 20698146.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
  • [Chemical-registry-number] 0 / Keratin-7
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30. Ghosh L, Dahut W, Kakar S, Posadas EM, Torres CG, Cancel-Santiago R, Ghosh BC: Management of patients with metastatic cancer of unknown primary. Curr Probl Surg; 2005 Jan;42(1):12-66
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  • [Title] Management of patients with metastatic cancer of unknown primary.
  • [MeSH-major] Neoplasm Metastasis / diagnosis. Neoplasm Metastasis / therapy. Neoplasms, Unknown Primary / pathology
  • [MeSH-minor] Adenocarcinoma / secondary. Adenocarcinoma / therapy. Biomarkers, Tumor / analysis. Brain Neoplasms / secondary. Breast Neoplasms / diagnosis. Breast Neoplasms / secondary. Carcinoma, Hepatocellular / diagnosis. Carcinoma, Neuroendocrine / diagnosis. Carcinoma, Small Cell / genetics. Carcinoma, Small Cell / secondary. Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / therapy. Cell Differentiation. Cytogenetic Analysis. Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / pathology. Humans. Immunohistochemistry. Keratins / metabolism. Liver Neoplasms / diagnosis. Lymphatic Metastasis. Magnetic Resonance Imaging. Mesothelioma / diagnosis. Mesothelioma / metabolism. Peritoneal Neoplasms / pathology. Positron-Emission Tomography. Prognosis. Rhabdomyosarcoma / pathology. Tomography, X-Ray Computed. Urinary Bladder Neoplasms / diagnosis. Urinary Bladder Neoplasms / secondary

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  • (PMID = 15711508.001).
  • [ISSN] 0011-3840
  • [Journal-full-title] Current problems in surgery
  • [ISO-abbreviation] Curr Probl Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
  • [Number-of-references] 147
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31. Pekáriková A, Sánchez D, Palová-Jelínková L, Simsová M, Benes Z, Hoffmanová I, Drastich P, Janatková I, Mothes T, Tlaskalová-Hogenová H, Tucková L: Calreticulin is a B cell molecular target in some gastrointestinal malignancies. Clin Exp Immunol; 2010 May;160(2):215-22
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  • Using enzyme-linked immunosorbent assay (ELISA), we found immunoglobulin (Ig)A and/or IgG anti-calreticulin antibodies in sera of approximately 63% of patients with hepatocellular carcinoma (HCC), 57% of patients with colorectal adenocarcinoma (CRA) and 47% of patients with pancreatic adenocarcinoma (PACA), while healthy controls, patients with viral hepatitis C and with chronic pancreatitis reached only 2%, 20% and 31% seropositivity, respectively.
  • Significantly elevated mean levels of IgG anti-calreticulin antibodies (P < 0.001) were detected in patients with HCC (121.9 +/- 94.2 AU), gall bladder adenocarcinoma (118.4 +/- 80.0 AU) and PACA (88.7 +/- 55.6 AU) when compared to healthy controls (56.7 +/- 22.9 AU).
  • [MeSH-major] Adenocarcinoma / immunology. Antibodies, Neoplasm / immunology. Autoantibodies / immunology. Autoantigens / immunology. B-Lymphocytes / immunology. Calreticulin / immunology. Carcinoma, Hepatocellular / immunology. Colorectal Neoplasms / immunology. Liver Neoplasms / immunology. Neoplasm Proteins / immunology. Pancreatic Neoplasms / immunology

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  • (PMID = 20030668.001).
  • [ISSN] 1365-2249
  • [Journal-full-title] Clinical and experimental immunology
  • [ISO-abbreviation] Clin. Exp. Immunol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Neoplasm; 0 / Autoantibodies; 0 / Autoantigens; 0 / Calreticulin; 0 / Epitopes; 0 / Immunoglobulin A; 0 / Immunoglobulin G; 0 / Neoplasm Proteins
  • [Other-IDs] NLM/ PMC2857944
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32. Wright JL, Porter MP, Li CI, Lange PH, Lin DW: Differences in survival among patients with urachal and nonurachal adenocarcinomas of the bladder. Cancer; 2006 Aug 15;107(4):721-8
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  • [Title] Differences in survival among patients with urachal and nonurachal adenocarcinomas of the bladder.
  • BACKGROUND: Primary adenocarcinomas of the bladder and urachus are rare malignancies, and knowledge of the patient demographics, pathologic characteristics, and survival associated with these tumors is poor.
  • The current study compares disease-specific characteristics and survival associated with urachal and nonurachal primary bladder adenocarcinomas.
  • METHODS: Incident cases of urachal and nonurachal primary adenocarcinomas of the bladder were identified from the Surveillance, Epidemiology, and End Results (SEER) Program.
  • Demographic and pathologic characteristics at the time of diagnosis were compared.
  • Risks of mortality among urachal and nonurachal primary adenocarcinomas of the bladder were compared using multivariate Cox regression.
  • RESULTS: A total of 151 urachal and 1374 nonurachal adenocarcinomas of the bladder patients were identified.
  • Compared to those with nonurachal tumors, patients with urachal adenocarcinoma were more likely to be younger (median age, 56 vs. 69 years, P <.0001) and female (45% vs. 36%, P = .02).
  • CONCLUSIONS. Urachal adenocarcinomas represent 10% of all primary adenocarcinomas of the bladder.
  • [MeSH-major] Adenocarcinoma / mortality. Urachus. Urinary Bladder Neoplasms / mortality

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  • (PMID = 16826584.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Wolk M, Martin JE, Reinus C: Development of fetal haemoglobin-blood cells (F cells) within colorectal tumour tissues. J Clin Pathol; 2006 Jun;59(6):598-602
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  • AIM: To evaluate the sources of fetal haemoglobin (HbF) as an indicator in cancer.
  • An immunohistochemical study was carried out on some of the most common kinds of cancer.
  • METHODS: Immunoaffinity-purified anti-HbF was immunohistochemically used to study F cell distribution in the following cancers: colorectal adenocarcinoma, urinary bladder transitional cell carcinoma, brain tumours, lung carcinoma, breast adenocarcinoma, leukaemia, Burkitt's lymphoma and endometrial carcinoma.
  • RESULTS: In colorectal adenocarcinoma, HbF-containing red blood cells (FRBC) were present within thin-walled vessels or were disposed in dense clusters within the tumour.
  • In half of the cases with transitional cell carcinoma of the urinary bladder, regional intratumoral blood vessels were found to contain 5-50% FRBC.
  • In the other tumours examined, F cells were not observed.
  • [MeSH-major] Adenocarcinoma / blood supply. Colorectal Neoplasms / blood supply. Fetal Hemoglobin / metabolism. Neovascularization, Pathologic / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Brain Neoplasms / blood supply. Breast Neoplasms / blood supply. Erythroblasts / metabolism. Female. Humans. Leukemia / blood. Lung Neoplasms / blood supply. Male. Middle Aged. Urinary Bladder Neoplasms / blood supply

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  • (PMID = 16469830.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 9034-63-3 / Fetal Hemoglobin
  • [Other-IDs] NLM/ PMC1860403
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34. Abe T, Hayashi T, Nakayama J, Kishikawa H, Sekii K, Yoshioka T, Itatani H, Kojima Y, Takahara S: [A case of synchronous double primary cancers of prostate, and bladder in a hemodialysis patient: a case report]. Hinyokika Kiyo; 2005 Oct;51(10):689-93
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  • [Title] [A case of synchronous double primary cancers of prostate, and bladder in a hemodialysis patient: a case report].
  • Cystoscopy revealed papillary tumors on the right lateral bladder wall.
  • Transurethral resection of bladder tumor (TUR-Bt) was performed and histopathological examination showed transitional cell carcinoma, G2, pTa.
  • The histologic diagnosis of the transrectal needle prostate biopsy specimen was moderately differentiated adenocarcinoma.
  • A case of synchronous double primary cancers, comprised of adenocarcinoma of the prostate and transitional cell carcinoma of the urinary blader in a hemodialysis patient has never been previously reported in the Japanese literature.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Transitional Cell / diagnosis. Neoplasms, Multiple Primary. Prostatic Neoplasms / diagnosis. Renal Dialysis. Urinary Bladder Neoplasms / diagnosis


35. Chalasani V, Macek P, O'Neill GF, Barret W: Ureteric stricture secondary to unusual extension of prostatic adenocarcinoma. Can J Urol; 2010 Feb;17(1):5031-4
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  • [Title] Ureteric stricture secondary to unusual extension of prostatic adenocarcinoma.
  • This article describes an unusual finding in a patient who presented with an adenocarcinoma of the prostate and right hydronephrosis.
  • Cystoscopy showed an exophytic superficial transitional cell carcinoma (TCC) of the bladder and a transrectal biopsy of the prostate confirmed adenocarcinoma Gleason score 4+3.
  • Staging investigations (CT pelvis and bone scan) were negative; androgen deprivation therapy was therefore initiated for the prostatic adenocarcinoma.
  • With a working diagnosis of upper tract TCC, right open nephroureterectomy was performed.
  • Final histology showed prostatic adenocarcinoma infiltrating the adventitia of the entire ureter up to the level of the renal pelvis.
  • A rare cause of ureteric stricture, contiguous spread of prostatic adenocarcinoma, should be considered in the differential diagnosis of patients presenting with upper tract obstruction and a known history of prostatic adenocarcinoma.
  • Androgen deprivation therapy for several months did not seem to cause resolution of the tumor in the periureteric, ureteric and perihilar tissues.
  • [MeSH-major] Adenocarcinoma / pathology. Prostatic Neoplasms / pathology. Ureter / pathology. Ureteral Obstruction / etiology


36. Hao H, Tsujimoto M, Tsubamoto H, Komori S, Hirota S: Immunohistochemical phenotype of the urinary bladder endocervicosis: comparison with normal endocervix and well-differentiated mucinous adenocarcinoma of uterine cervix. Pathol Int; 2010 Jul;60(7):528-32
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  • [Title] Immunohistochemical phenotype of the urinary bladder endocervicosis: comparison with normal endocervix and well-differentiated mucinous adenocarcinoma of uterine cervix.
  • Endocervicosis of the urinary bladder is a very rare tumor-like benign lesion.
  • Transvaginal ultrasound, cystoscopy and magnetic resonance imaging demonstrated a solid mass in the posterior wall of the bladder.
  • The mass was removed and histology revealed a haphazard proliferation of endocervical-type mucinous glands scattered through the muscularis propria of bladder wall.
  • Immunohistochemical phenotype of these glands was compared with three normal uterine endocervices and two cases of well-differentiated mucinous adenocarcinoma of the uterine cervix.
  • On the other hand, only glands of well-differentiated mucinous adenocarcinoma expressed human gastric mucin and showed high proliferative index of Ki-67.
  • Furthermore, diffuse distribution of estrogen and progesterone receptors, lack of human gastric mucin and low proliferative activity were distinct features for endocervicosis compared to well-differentiated mucinous adenocarcinoma.
  • [MeSH-major] Cervix Uteri. Choristoma / pathology. Urinary Bladder Diseases / pathology
  • [MeSH-minor] Adenocarcinoma, Mucinous / pathology. Adult. Cesarean Section. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Phenotype. Pregnancy. Uterine Cervical Neoplasms / metabolism. Uterine Cervical Neoplasms / pathology


37. Crow P, Molckovsky A, Stone N, Uff J, Wilson B, WongKeeSong LM: Assessment of fiberoptic near-infrared raman spectroscopy for diagnosis of bladder and prostate cancer. Urology; 2005 Jun;65(6):1126-30
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  • [Title] Assessment of fiberoptic near-infrared raman spectroscopy for diagnosis of bladder and prostate cancer.
  • OBJECTIVES: To determine whether a fiberoptic Raman system, suitable for in vivo use, is able to differentiate between benign and malignant bladder and prostate pathologic findings in vitro.
  • Laboratory studies have shown that the technique can be used to identify and characterize transitional cell carcinoma and prostate adenocarcinoma in vitro.
  • METHODS: A total of 220 Raman spectra were recorded from 29 snap-frozen bladder samples collected at cystoscopic procedures, and 197 Raman spectra were recorded from 38 snap-frozen prostate samples collected at transurethral resection of the prostate.
  • The spectra were correlated with the histologic features and used to construct separate diagnostic algorithms for the bladder and prostate.
  • RESULTS: The bladder algorithm was able to differentiate benign samples (normal and cystitis) from malignant samples (transitional cell carcinoma), with an overall accuracy of 84%.
  • The prostate algorithm was able to differentiate benign samples (benign prostatic hyperplasia and prostatitis) from malignant samples (prostate cancer), with an overall accuracy of 86%.
  • CONCLUSIONS: The results of this study have demonstrated that the clinical Raman system can provide an accurate and objective method to diagnose prostate and bladder cancer in vitro.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Transitional Cell / diagnosis. Prostatic Neoplasms / diagnosis. Spectroscopy, Near-Infrared. Urinary Bladder Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Fiber Optic Technology. Humans. In Vitro Techniques. Male. Sensitivity and Specificity


38. Osunkoya AO, Epstein JI: Primary mucin-producing urothelial-type adenocarcinoma of prostate: report of 15 cases. Am J Surg Pathol; 2007 Sep;31(9):1323-9
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  • [Title] Primary mucin-producing urothelial-type adenocarcinoma of prostate: report of 15 cases.
  • Prostatic urothelial-type adenocarcinoma arises through a process of glandular metaplasia of the prostatic urethral urothelium and subsequent in situ adenocarcinoma sometimes associated with villous adenoma.
  • These prostatic adenocarcinomas are analogous to nonurachal adenocarcinomas arising in the bladder from cystitis glandularis.
  • Only 2 cases of urothelial-type adenocarcinoma from an institution other than our own have been previously described.
  • The distinction between adenocarcinoma from another organ secondarily involving the prostate, usual adenocarcinoma of the prostate, and prostatic urothelial-type adenocarcinoma can present a significant diagnostic challenge and has significant therapeutic implications.
  • Fifteen cases of prostatic urothelial-type adenocarcinoma were retrieved from the consult files of one of the authors.
  • Mean patient age at diagnosis was 72 years (range 58 to 93 y).
  • Bladder primaries were ruled out clinically or pathologically in radical resection specimens.
  • Follow-up was available on all men with a mean of 50.3 months (range 2 to 161 mo).
  • All men presented with urinary obstruction symptoms with 3 (20%) also having mucusuria and 2 (13.3%) also having hematuria.
  • In 8/15 (53%) cases, glandular metaplasia of the prostatic urethra and contiguous transition to adenocarcinoma were identified.
  • Prostatic urothelial-type adenocarcinoma is a rare aggressive cancer arising in the prostate.
  • The differential diagnosis includes conventional prostatic mucinous adenocarcinoma and secondary infiltration from a colonic or bladder adenocarcinoma.
  • Immunohistochemistry for prostate specific antigen, prostate specific acid phosphatase, and high molecular weight cytokeratin along with morphology can help rule out conventional prostate carcinoma. beta-catenin, CDX2, and clinical studies are needed to rule out colonic adenocarcinoma.
  • As prostatic urothelial-type adenocarcinoma is entirely analogous to bladder adenocarcinoma in both, its morphology and immunophenotype, only clinical studies or in some cases pathologic examination of the cystoprostatectomy specimen can exclude infiltration from a primary bladder adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma, Mucinous / diagnosis. Mucins / analysis. Prostatic Neoplasms / diagnosis. Urothelium / pathology
  • [MeSH-minor] Acid Phosphatase. Aged. Aged, 80 and over. Cell Differentiation. Diagnosis, Differential. Follow-Up Studies. Homeodomain Proteins / analysis. Humans. Immunohistochemistry. Keratin-20 / analysis. Keratin-7 / analysis. Male. Middle Aged. Neoplasm Invasiveness. Prognosis. Prostate-Specific Antigen / analysis. Protein Tyrosine Phosphatases / analysis. Time Factors. beta Catenin / analysis

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  • (PMID = 17721186.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CDX2 protein, human; 0 / CTNNB1 protein, human; 0 / Homeodomain Proteins; 0 / KRT20 protein, human; 0 / KRT7 protein, human; 0 / Keratin-20; 0 / Keratin-7; 0 / Mucins; 0 / beta Catenin; EC 3.1.3.2 / Acid Phosphatase; EC 3.1.3.2 / prostatic acid phosphatase; EC 3.1.3.48 / Protein Tyrosine Phosphatases; EC 3.4.21.77 / Prostate-Specific Antigen
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39. Smith AK, Hansel DE, Jones JS: Role of cystitis cystica et glandularis and intestinal metaplasia in development of bladder carcinoma. Urology; 2008 May;71(5):915-8
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  • [Title] Role of cystitis cystica et glandularis and intestinal metaplasia in development of bladder carcinoma.
  • OBJECTIVES: Cystitis cystica et glandularis (CCEG) and intestinal metaplasia (IM) have been suggested to represent precursors of bladder adenocarcinoma.
  • The relationship between these entities and the subsequent development of bladder carcinoma remains unclear.
  • METHODS: We retrospectively evaluated the association among florid CCEG, IM, and bladder carcinoma.
  • The records and imaging findings of patients with a pathologic diagnosis of florid CCEG and/or IM were reviewed for a concurrent or future diagnosis of bladder carcinoma or pelvic lipomatosis.
  • Of the 117 patients with CCEG, a subset was identified with concurrent mucinous adenocarcinoma (n = 1; <1%), squamous cell carcinoma (n = 4; 3%), or urothelial carcinoma (n = 34; 29%) at diagnosis.
  • Pure IM was identified concurrently with adenocarcinoma in 2 (10%), urothelial carcinoma in 4 (21%), and urothelial carcinoma with glandular differentiation in 1 (5%) of 19 patients.
  • CONCLUSIONS: Both florid CCEG and IM can be identified in benign bladder specimens or in conjunction with bladder carcinoma.
  • Although IM can be associated with a concurrent diagnosis of carcinoma, we found no evidence that it increases the future risk of malignancy and our findings do not support a recommendation for surveillance cystoscopy in such patients.
  • [MeSH-major] Cystitis / complications. Intestines / pathology. Precancerous Conditions / pathology. Urinary Bladder Neoplasms / etiology

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  • (PMID = 18455631.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. Naspro R, Suardi N, Salonia A, Scattoni V, Guazzoni G, Colombo R, Cestari A, Briganti A, Mazzoccoli B, Rigatti P, Montorsi F: Holmium laser enucleation of the prostate versus open prostatectomy for prostates &gt;70 g: 24-month follow-up. Eur Urol; 2006 Sep;50(3):563-8
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  • Patients were evaluated at 1-, 3-, 12-, and 24-mo follow-ups with the same tests.
  • In both groups urodynamic and uroflowmetry findings improved from baseline, were still evident at the 24-mo follow-up, and were comparable between the two groups.
  • [MeSH-major] Holmium / therapeutic use. Laser Therapy / methods. Prostate / pathology. Prostatectomy / methods. Prostatic Hyperplasia / surgery. Urinary Bladder Neck Obstruction / surgery
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Aged. Follow-Up Studies. Humans. Male. Middle Aged. Morbidity. Organ Size. Perioperative Care. Postoperative Complications / epidemiology. Prostatic Neoplasms / diagnosis. Prostatic Neoplasms / surgery. Radioisotopes / therapeutic use

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  • [CommentIn] Eur Urol. 2006 Sep;50(3):418-20 [16687204.001]
  • (PMID = 16713070.001).
  • [ISSN] 0302-2838
  • [Journal-full-title] European urology
  • [ISO-abbreviation] Eur. Urol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Radioisotopes; W1XX32SQN1 / Holmium
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41. Bestard Vallejo JE, Orsola de los Santos A, Raventós Busquets CX, Planas Morin J, Morote Robles J: [Closure of a neobladder-vaginal fistula in a patient with Studer's type neobladder using a transvaginal approach with interposition of a Martius' flap]. Arch Esp Urol; 2009 Jan-Feb;62(1):56-9
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  • [Transliterated title] Cierre de fístula neovésico-vaginal en paciente con neovejiga tipo Studer mediante abordaje transvaginal con interposición de colgajo de Martius.
  • METHODS: A 51-year-old patient required cystectomy and Studer's neobladder for invasive bladder adenocarcinoma.
  • [MeSH-major] Postoperative Complications / surgery. Surgical Flaps. Urinary Reservoirs, Continent. Vaginal Fistula / surgery

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  • (PMID = 19400447.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 10
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42. Ozcanli H, Ozdemir H, Ozenci AM, Söyüncü Y, Aydin AT: [Metastatic tumors of the hand in three cases]. Acta Orthop Traumatol Turc; 2005;39(5):445-8
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  • Metastases developed in the thumb and the big toe, metacarpal bone, and the nail bed following treatment for primary tumors of the bladder, colon, and chondrosarcoma of the proximal femur, respectively.
  • [MeSH-major] Adenocarcinoma / diagnosis. Bone Neoplasms / diagnosis. Hand
  • [MeSH-minor] Adult. Colonic Neoplasms / diagnosis. Colonic Neoplasms / pathology. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. Urinary Bladder Neoplasms / diagnosis. Urinary Bladder Neoplasms / pathology

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  • (PMID = 16531705.001).
  • [ISSN] 1017-995X
  • [Journal-full-title] Acta orthopaedica et traumatologica turcica
  • [ISO-abbreviation] Acta Orthop Traumatol Turc
  • [Language] tur
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Turkey
  • [Number-of-references] 25
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43. Kitley CA, Mosier AD, Keylock J, Nguyen D: Malignant priapism secondary to adenocarcinoma of the prostate. BMJ Case Rep; 2010;2010
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  • [Title] Malignant priapism secondary to adenocarcinoma of the prostate.
  • The authors report a case of an older gentleman with a history of metastatic prostate cancer who presented to the emergency department following 3 weeks of progressively intermittent and then continuous priapism.
  • [MeSH-major] Adenocarcinoma / diagnosis. Penile Neoplasms / secondary. Priapism / etiology. Prostatic Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biopsy, Large-Core Needle. Bone Neoplasms / diagnosis. Bone Neoplasms / secondary. Diagnosis, Differential. Disease Progression. Fatal Outcome. Follow-Up Studies. Humans. Image Interpretation, Computer-Assisted. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Lymphatic Metastasis / pathology. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness. Palliative Care. Penis / pathology. Prostate / pathology. Tomography, X-Ray Computed. Urinary Bladder / pathology

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  • [Cites] Radiographics. 2001 Oct;21 Spec No:S283-98; discussion S298-9 [11598264.001]
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  • (PMID = 22789733.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3028547
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44. Blah M, Gobet F, Dugardin F, Catovic B, Loisel F, Pfister C: [Elevation of total PSA after intravesical BCG instillations: granulomatous prostatitis or prostatic adenocarcinoma?]. Prog Urol; 2008 Feb;18(2):108-13
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  • [Title] [Elevation of total PSA after intravesical BCG instillations: granulomatous prostatitis or prostatic adenocarcinoma?].
  • [Transliterated title] Elévation du PSA total après instillations endovesicales de BCG: prostatite granulomateuse ou adénocarcinome prostatique?
  • OBJECTIVE: The objective of this study was to evaluate the incidence of prostatic carcinoma in patients treated by intravesical BCG-therapy for superficial bladder cancer and presenting granulomatous prostatitis.
  • A total of 153 men were treated for high-risk or intermediate-risk superficial bladder cancer according to the usual recommendations.
  • Ultrasound-guided biopsies were indicated in view of the persistently elevated PSA level and confirmed the tuberculoid granulomatous lesion of the prostate in each case and revealed prostatic adenocarcinoma in two patients.
  • [MeSH-major] Adenoma / diagnosis. BCG Vaccine / administration & dosage. Prostate-Specific Antigen / blood. Prostatic Neoplasms / diagnosis. Prostatitis / diagnosis. Urinary Bladder Neoplasms / drug therapy
  • [MeSH-minor] Administration, Intravesical. Diagnosis, Differential. Drug Administration Schedule. Humans. Male. Retrospective Studies


45. Sun K, Huan Y, Unger PD: Clear cell adenocarcinoma of urinary bladder and urethra: another urinary tract lesion immunoreactive for P504S. Arch Pathol Lab Med; 2008 Sep;132(9):1417-22
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  • [Title] Clear cell adenocarcinoma of urinary bladder and urethra: another urinary tract lesion immunoreactive for P504S.
  • CONTEXT: Clear cell carcinoma of the urinary bladder/ urethra is a rare tumor histologically resembling the neoplasms in the female genital tract.
  • Adequate characterization of this tumor has been hampered by its rarity. alpha-Methylacyl-CoA racemase (AMACR)/P504S has been reported to be positive in prostatic adenocarcinoma, papillary renal cell carcinoma, and gastrointestinal neoplasmas; however, it has never been studied in clear cell carcinoma of the lower urinary tract.
  • OBJECTIVE: To investigate the immunohistochemical staining profile in 4 primary clear cell carcinomas of the urinary tract, including P504S, which has not been previously evaluated in these tumors.
  • DESIGN: Four cases of clear cell adenocarcinoma were retrieved from our archives: 2 cases from the urinary bladder (one each from a man and a woman) and 2 cases from the urethra (both from women, 1 in a diverticulum).
  • This staining profile may suggest a nonurothelial origin for these tumors, may serve as a useful tool in the differential diagnosis of this tumor, and may reflect its etiology.
  • Because similar expression of P504S is also seen in nephrogenic adenomas, this marker should not be used to differentiate nephrogenic adenomas from clear cell adenocarcinomas.
  • [MeSH-major] Adenocarcinoma, Clear Cell / metabolism. Biomarkers, Tumor / analysis. Racemases and Epimerases / biosynthesis. Urethral Neoplasms / metabolism. Urinary Bladder Neoplasms / metabolism

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  • (PMID = 18788852.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-125 Antigen; 0 / CKAP4 protein, human; 0 / Keratin-20; 0 / Keratin-7; 0 / Membrane Proteins; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
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46. Demir OI, Obuz F, Sağol O, Dicle O: Contribution of diffusion-weighted MRI to the differential diagnosis of hepatic masses. Diagn Interv Radiol; 2007 Jun;13(2):81-6
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  • [Title] Contribution of diffusion-weighted MRI to the differential diagnosis of hepatic masses.
  • Malignant masses included 8 metastases, 4 hepatocellular carcinomas, 4 cholangiocellular carcinomas, and 1 gall bladder adenocarcinoma.
  • [MeSH-major] Liver Diseases / diagnosis. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Liver Neoplasms / diagnosis. Liver Neoplasms / pathology. Male. Middle Aged. Neoplasm Metastasis. Predictive Value of Tests

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  • (PMID = 17562512.001).
  • [ISSN] 1305-3825
  • [Journal-full-title] Diagnostic and interventional radiology (Ankara, Turkey)
  • [ISO-abbreviation] Diagn Interv Radiol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Turkey
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47. Martínez-Cornelio A, Flores-López D, Ojeda RF, Quintero-Becerra J, Hernández-Toriz N: [Surgical experience with urachal carcinoma]. Cir Cir; 2009 Jan-Feb;77(1):33-8
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  • [Transliterated title] Experiencia quirúrgica en el adenocarcinoma de uraco.
  • BACKGROUND: Urachal carcinomas are rare neoplasms that constitute <1% of bladder tumors.
  • Clinical files were reviewed of patients with diagnosis of bladder cancer and who were operated on with radical cystectomy with urinary substitution and extended partial cystectomy, selecting those patients with pathological report of urachal carcinoma.
  • RESULTS: Of the 306 patients operated on with radical surgery for bladder cancer, only five patients (1.6%) had a diagnosis of urachal carcinoma.
  • In the other four cases, tumor was reported in the dome of the bladder and for this reason cystoscopy and transurethral resection of the bladder (TURB) were done, confirming the clinical findings in addition to the pathology report suggesting urachal carcinoma.
  • This was the reason for the Studer-type orthotopic bladder substitution.
  • Symptoms in most cases are similar to those of bladder pathology origin.
  • [MeSH-major] Adenocarcinoma / surgery. Urachus. Urinary Bladder Neoplasms / surgery

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  • (PMID = 19344561.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
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48. Soares MJ, Neves T, Covita A, Monteiro P, Canhoto A, Nogueira R, Barreto JL, Mendonça JC, Maya M, Monteiro H: [Bladder adenocarcinoma. Case report]. Arch Esp Urol; 2008 Sep;61(7):828-31
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  • [Title] [Bladder adenocarcinoma. Case report].
  • [Transliterated title] Adenocarcinoma vesical. Aportación de un caso clínico.
  • OBJECTIVE: Primary bladder adenocarcinoma is a rare entity.
  • METHOD/RESULTS: A 74 year old female patient presents to the emergency department with complaints of gross hematúria not accompanied by lower urinary tract symptoms.
  • Diagnostic work-up included renal and bladder ultrasound, cistoscopy and abdomino-pelvic C. T. scan.
  • Trans-urethral resection revealed an invasive adenocarcinoma.
  • The bladder specimen showed primary bladder adenocarcinoma, pT3aNO.
  • At 6 months of follow-up, the patient does not present disease progression or surgical complications.
  • CONCLUSION: Primary bladder adenocarcinoma is rare.
  • [MeSH-major] Adenocarcinoma. Urinary Bladder Neoplasms

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  • (PMID = 18972921.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 17
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49. Wood B, Sterrett G, Frost F, Swarbrick N: Diagnosis of extramammary malignancy metastatic to the breast by fine needle biopsy. Pathology; 2008 Jun;40(4):345-51
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  • [Title] Diagnosis of extramammary malignancy metastatic to the breast by fine needle biopsy.
  • RESULTS: The 32 cases included metastases from a wide range of sites, including cutaneous melanoma (10), lung (8), non-Hodgkin's lymphoma (5), soft tissue (4), colon (2), endometrium, ovary and bladder.
  • Only one case was initially mistaken for a primary tumour, in this case the history of prior malignancy with systemic metastases was not provided to the reporting pathologist.
  • The cytological features allow metastatic disease to be suspected in half of the cases, although in the others, particularly patients with metastatic adenocarcinoma, diagnosis without recourse to immunohistochemistry is difficult or impossible.
  • [MeSH-major] Adenocarcinoma / secondary. Breast Neoplasms / secondary. Lung Neoplasms / pathology. Lymphoma, Non-Hodgkin / pathology. Melanoma / secondary. Skin Neoplasms / pathology


50. Zaghloul MS, Nouh A, Nazmy M, Ramzy S, Zaghloul AS, Sedira MA, Khalil E: Long-term results of primary adenocarcinoma of the urinary bladder: a report on 192 patients. Urol Oncol; 2006 Jan-Feb;24(1):13-20
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  • [Title] Long-term results of primary adenocarcinoma of the urinary bladder: a report on 192 patients.
  • OBJECTIVES: To evaluate the clinical presentation and treatment end results of primary adenocarcinoma of the urinary bladder, and to determine the significant independent prognostic factors that determine this outcome.
  • PATIENTS AND METHODS: Of 3659 patients who underwent cystectomy, 192 had adenocarcinoma of the urinary bladder, with a relative frequency of 5.2%.
  • Mucinous adenocarcinoma was reported in 28 patients (14.6%), papillary in 20 (10.4%), signet ring in 14 (7.3%), while not otherwise specified was reported in 130 (67.7%) in the cystectomy specimens.
  • RESULTS: Mucinous and signet-ring histologic subtypes showed increased frequency of high stages and high grades, and more nodal involvement than the papillary and not otherwise specified.
  • The 5-year disease-free survival rate was 46 +/- 4% for all patients with adenocarcinoma.
  • The disease-free survival independent prognostic variables were tumor stage, postoperative radiotherapy, nodal involvement, and adenocarcinoma subclassification.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Adenocarcinoma / surgery. Cystectomy. Urinary Bladder Neoplasms / radiotherapy. Urinary Bladder Neoplasms / surgery

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  • (PMID = 16414487.001).
  • [ISSN] 1078-1439
  • [Journal-full-title] Urologic oncology
  • [ISO-abbreviation] Urol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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51. Lee JI: Micropapillary carcinoma of the urinary bladder: a case report. Acta Cytol; 2009 May-Jun;53(3):344-8
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  • [Title] Micropapillary carcinoma of the urinary bladder: a case report.
  • Urine cytology contained tight clusters of atypical cells, originally interpreted as high-grade urothelial carcinoma or adenocarcinoma.
  • Final diagnosis was made by histology and immunohistochemical study.
  • Careful cytologic examination in combination with cell block morphology and immunohistochemistry may allow early accurate diagnosis and appropriate management.
  • [MeSH-major] Carcinoma, Papillary / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 19534282.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins; 0 / Mucin-1
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52. Livi L, Detti B, Meattini M, Sánchez LJ, Biti GP: [Organ-confined prostate cancer: treatment with high doses of radioterapy (intensity modulated radiotherapy)]. Actas Urol Esp; 2007 Jun;31(6):611-6
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  • [Title] [Organ-confined prostate cancer: treatment with high doses of radioterapy (intensity modulated radiotherapy)].
  • [Transliterated title] Cancer de próstata órgano-confinado: tratamiento con altas dosis de radioterapia (radioterapia de intensidad modulada).
  • PURPOSE: To report toxicity and local control in patients with localized prostate cancer, treated with high dose radiotherapy.
  • MATERIALS AND METHODS: The records of 100 consecutive patients with clinically localized prostate cancer treated between june 2003 and may 2006 were reviewed.
  • Forty-four (44%) developed acute Grade 2 urinary symptoms while 34% of the patients experienced no GU symptoms (Grade 0) during treatment.
  • Three patients (3%) developed late rectal toxicity grade 2 and eight patients (8%) experienced late urinary toxicity grade 2; any patients experienced more severe symptoms.
  • We recorded biochemical relapse in two patients, both had poor prognostic factors at initial diagnosis of prostate cancer.
  • CONCLUSIONS: The data demonstrate the feasibility and safety of high dose radiotherapy for patients with localized prostate cancer and provide a proof that this method allow safe dose escalation with low severe toxicities to the normal tissues.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Prostatic Neoplasms / radiotherapy. Radiotherapy, Intensity-Modulated
  • [MeSH-minor] Aged. Aged, 80 and over. Feasibility Studies. Gastrointestinal Diseases / epidemiology. Gastrointestinal Diseases / etiology. Humans. Male. Middle Aged. Radiation Injuries / epidemiology. Radiation Injuries / etiology. Radiotherapy Dosage. Rectum / radiation effects. Retrospective Studies. Urinary Bladder / radiation effects. Urination Disorders / epidemiology. Urination Disorders / etiology


53. Yoshida T, Nishimura K, Harada Y, Ujike T, Uemura M, Nin M, Miyoshi S, Kawano K: [Primary adenocarcinoma of renal pelvis and ureter suspected as metastatic tumor: a case report]. Hinyokika Kiyo; 2007 Apr;53(4):247-50
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  • [Title] [Primary adenocarcinoma of renal pelvis and ureter suspected as metastatic tumor: a case report].
  • A 58-year-old man, who had undergone sigmoidectomy for sigmoid colon adenocarcinoma 3 years earlier, was referred to our clinic because of left ureteral tumor incidentally found by computed tomography (CT).
  • Under the diagnosis of left ureteral carcinoma, retroperitoneoscopic left nephroureterectomy was performed.
  • Pathological examination revealed adenocarcinoma of the left renal pelvis and ureter.
  • Subtype of the adenocarcinoma was 'enteric type'.
  • By the transurethral resection of the tumors, bladder tumors appeared to be adenocarcinoma.
  • Carefully considering the pathological findings and clinical course, we concluded that the tumor was not metastatic but primary adenocarcinoma followed by intravesical recurrence.
  • [MeSH-major] Adenocarcinoma / secondary. Kidney Neoplasms / secondary. Kidney Pelvis. Neoplasms, Second Primary. Sigmoid Neoplasms / pathology. Ureteral Neoplasms / secondary. Urinary Bladder Neoplasms / diagnosis
  • [MeSH-minor] Colon, Sigmoid / surgery. Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 17515075.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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54. Wu SD, Rios RR, Meeks JJ, Nadler RB: Rectal Hem-o-Lok clip migration after robot-assisted laparoscopic radical prostatectomy. Can J Urol; 2009 Dec;16(6):4939-40
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  • INTRODUCTION: Weck Hem-o-Lok clip migration into the bladder has been reported after robot-assisted laparoscopic radical prostatectomy (RALP).
  • METHODS: A 61-year-old male with a prostate specific antigen level of 4.84 ng/ml underwent transrectal ultrasound guided biopsy of the prostate revealing a Gleason's 3 + 3 adenocarcinoma of the prostate involving 20% of the sampled tissue for the left apex.
  • RESULTS: Final pathology demonstrated a Gleason 4 + 3 pT2cN0Mx adenocarcinoma of the prostate with negative margins.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Colonoscopy / methods. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging

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  • (PMID = 20003674.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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55. Mohile SG, Schleicher L, Petrylak DP: Treatment of metastatic urachal carcinoma in an elderly woman. Nat Clin Pract Oncol; 2008 Jan;5(1):55-8
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  • Imaging revealed a large pelvic mass situated on the dome of the bladder, extending from the urachus, without evidence of other sites of metastases.
  • After resection, urachal adenocarcinoma was histologically confirmed.
  • DIAGNOSIS: Metastatic urachal adenocarcinoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Signet Ring Cell / secondary. Cystectomy. Lymph Node Excision. Pelvic Neoplasms / secondary. Urachus. Urinary Bladder Neoplasms / surgery
  • [MeSH-minor] Aged. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Combined Modality Therapy. Diagnosis, Differential. Female. Fluorouracil / administration & dosage. Humans. Leucovorin / administration & dosage. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery. Radiotherapy, Adjuvant

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  • (PMID = 18097457.001).
  • [ISSN] 1743-4262
  • [Journal-full-title] Nature clinical practice. Oncology
  • [ISO-abbreviation] Nat Clin Pract Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 7673326042 / irinotecan; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin; IFL protocol
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56. Singh I, Pachisia SS, Kumar S, Arora VK, Kumar P: Emphysematous pyelonephritis: a consequence of adenocarcinoma of urinary bladder in a nondiabetic patient. J Postgrad Med; 2005 Oct-Dec;51(4):324-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Emphysematous pyelonephritis: a consequence of adenocarcinoma of urinary bladder in a nondiabetic patient.
  • Emphysematous pyelonephritis (EP) is a life threatening condition of acute necrotising renal parenchymal infection that encompasses a much wider spectrum of complicated urinary tract infections such as renal abscesses, emphysematous pyelitis, pyelonephritis, acute renal papillary necrosis, and sepsis.
  • We report an unusual case of adenocarcinoma bladder in a middle aged nondiabetic patient, presenting with EP.
  • Emphysematous pyelonephritis was the initial symptom in this case with an underlying carcinoma of the bladder.
  • The role of imaging is prime in management of such cases, if an early diagnosis is to be made and a potentially devastating outcome is to be avoided.
  • [MeSH-major] Adenocarcinoma / complications. Emphysema / complications. Pyelonephritis / complications. Urinary Bladder Neoplasms / complications

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  • (PMID = 16388179.001).
  • [ISSN] 0022-3859
  • [Journal-full-title] Journal of postgraduate medicine
  • [ISO-abbreviation] J Postgrad Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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57. Ekici S, Dogan Ekici I, Ruacan S, Midi A: Xanthogranulomatous cystitis: a challenging imitator of bladder cancer. ScientificWorldJournal; 2010;10:1169-73
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  • [Title] Xanthogranulomatous cystitis: a challenging imitator of bladder cancer.
  • Xanthogranulomatous cystitis is a rare, benign, chronic inflammatory disease of the bladder, mimicking malignancy with unknown etiology.
  • Computerized tomography demonstrated an obstructing 10-mm stone in the lower third of the left ureter and a 6-cm solid mass on the right at the anterolateral wall of the bladder.
  • Cystouretroscopy revealed a mass protruding into the bladder cavity with edematous smooth surface.
  • Frozen section analysis of the partial cystectomy specimen could not rule out malignancy.
  • Localized prostatic adenocarcinoma was also found.
  • [MeSH-major] Cystitis / diagnosis. Urinary Bladder Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 20602075.001).
  • [ISSN] 1537-744X
  • [Journal-full-title] TheScientificWorldJournal
  • [ISO-abbreviation] ScientificWorldJournal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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58. Ansari SM, Banu S, Awal MA, Siddique AB, Alam MM: Polypoid gall bladder lesions: is it necessary for immediate surgery? Bangladesh Med Res Counc Bull; 2007 Aug;33(2):44-7
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  • [Title] Polypoid gall bladder lesions: is it necessary for immediate surgery?
  • A total of 57 patients with polypoid lesions in gall bladder were diagnosed and underwent extensive follow-up.
  • In 31 patients, who underwent surgery, the histological findings were cholesterol polyp/cholesterosis (n=14), cholesterosis with fibrous displasia of gall bladder (n=7), adenomyomatosis (n=3), hyperplastic cholecystosis (n=5) and adenocarcinoma (n=2).
  • Remaining 26 patients were under follow-up up to 18 months from first diagnosis.

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  • (PMID = 18481437.001).
  • [ISSN] 0377-9238
  • [Journal-full-title] Bangladesh Medical Research Council bulletin
  • [ISO-abbreviation] Bangladesh Med Res Counc Bull
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Bangladesh
  • [Chemical-registry-number] 97C5T2UQ7J / Cholesterol
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59. Reid-Nicholson MD, Ramalingam P, Adeagbo B, Cheng N, Peiper SC, Terris MK: The use of Urovysion fluorescence in situ hybridization in the diagnosis and surveillance of non-urothelial carcinoma of the bladder. Mod Pathol; 2009 Jan;22(1):119-27
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  • [Title] The use of Urovysion fluorescence in situ hybridization in the diagnosis and surveillance of non-urothelial carcinoma of the bladder.
  • We evaluated Urovysion FISH in non-urothelial carcinoma involving bladder to determine its possible application to their diagnosis and surveillance.
  • Paraffin blocks from 31 non-urothelial bladder carcinomas, 12 pure urothelial carcinomas and 2 urothelial carcinomas with squamous differentiation were tested according to Vysis-Abbot Laboratories' recommended standards.
  • Cases included 15 primary squamous carcinoma, 2 urothelial carcinoma with squamous differentiation, 4 primary adenocarcinoma, 5 colonic, 4 prostatic and 1 cervical adenocarcinoma.
  • In conclusion, we found that chromosomal abnormalities tested for by Urovysion FISH may be seen in non-urothelial carcinomas of bladder.
  • These false-positive results were frequent in primary and secondary adenocarcinoma and rare in squamous carcinoma.
  • This has significant implications for the accurate diagnosis and management of patients with urinary tract cancer.
  • Urovysion FISH cannot be used to definitively diagnose squamous carcinoma or adenocarcinoma nor can it be used to differentiate the two from urothelial carcinoma.
  • However, it may be useful as a surveillance tool in established primary and secondary bladder adenocarcinoma.
  • [MeSH-major] In Situ Hybridization, Fluorescence / methods. Urinary Bladder Neoplasms / diagnosis. Urinary Bladder Neoplasms / genetics

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  • (PMID = 18978733.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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60. Andreeva IuIu, Zavalishina LE, Frank GA: [Classification of urinary bladder tumors]. Arkh Patol; 2006 Sep-Oct;68(5):46-53
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  • [Title] [Classification of urinary bladder tumors].
  • The paper outlines the topical aspects of the current classification of urinary bladder epithelial tumors.
  • Difficulties in the microscopic diagnosis of different types of urothelial carcinoma, the specific features of gradation and staging, and possibilities of differential diagnosis are presented.
  • [MeSH-major] Urinary Bladder Neoplasms / classification
  • [MeSH-minor] Adenocarcinoma, Clear Cell / classification. Adenocarcinoma, Clear Cell / pathology. Adenoma, Villous / classification. Adenoma, Villous / pathology. Carcinoma, Papillary / classification. Carcinoma, Papillary / pathology. Carcinoma, Small Cell / classification. Carcinoma, Small Cell / pathology. Carcinoma, Squamous Cell / classification. Carcinoma, Squamous Cell / pathology. Carcinoma, Transitional Cell / classification. Carcinoma, Transitional Cell / pathology. Humans. Urothelium / pathology. World Health Organization

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  • (PMID = 17144533.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] English Abstract; Lectures
  • [Publication-country] Russia (Federation)
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61. Kalisvaart JF, Katsumi HK, Ronningen LD, Hovey RM: Bladder cancer in spinal cord injury patients. Spinal Cord; 2010 Mar;48(3):257-61
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  • [Title] Bladder cancer in spinal cord injury patients.
  • OBJECTIVE: Spinal cord injury is a known risk factor for bladder cancer.
  • The risk of bladder cancer has been reported at 16-28 times higher than the general population.
  • We examined the characteristics of bladder cancers in a spinal cord injury (SCI) population.
  • METHODS: We reviewed SCI patients seen and diagnosed with bladder tumors between January 1983 and January 2007.
  • Data collected included time since diagnosis, method of diagnosis, form of bladder management, pathologic type, treatment of the tumor, and outcome.
  • RESULTS: A total of 32 patients with bladder cancer were identified out of 1319 seen.
  • Tumors found were 46.9% squamous cell carcinoma (SCC), 31.3% transitional cell carcinoma (TCC), 9.4% adenocarcinoma, and 12.5% mixed TCC and SCC.
  • The primary form of bladder management was 44% urethral catheter for a mean of 33.3 years, 48% external catheter for a mean of 37.4 years, and 8% intermittent catheterization for a mean of 24.5 years.
  • Nineteen patients had a known method of cancer detection with 42% found on screening cystoscopy.
  • Over 50% of patients diagnosed with bladder cancer in our population did not have an indwelling catheter.
  • This suggests that the neurogenic bladder, not the indwelling catheter, may be the risk factor for bladder cancer.
  • Urologists should consider diligent, long-term screening of all patients with SCI for bladder cancer and not just those with indwelling catheters.
  • [MeSH-major] Adenocarcinoma / etiology. Carcinoma, Squamous Cell / etiology. Carcinoma, Transitional Cell / etiology. Spinal Cord Injuries / complications. Urinary Bladder Neoplasms / etiology
  • [MeSH-minor] Aged. Catheters, Indwelling / adverse effects. Female. Humans. Male. Middle Aged. Retrospective Studies. Risk Factors. Smoking / adverse effects. Smoking / epidemiology. Urinary Catheterization / adverse effects


62. Taniguchi H, Sakagami J, Suzuki N, Hasegawa H, Shinoda M, Tosa M, Baba T, Yasuda H, Kataoka K, Yoshikawa T: Adenoendocrine cell carcinoma of the gallbladder clinically mimicking squamous cell carcinoma. Int J Clin Oncol; 2009 Apr;14(2):167-70
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  • We present the case of a 62-year-old Japanese man whose histological diagnosis was adenoendocrine cell carcinoma of the gallbladder at autopsy, but whose antemortem diagnosis was squamous cell carcinoma.
  • Though tumor regression was achieved and his serum SCCA level normalized after 3 months, the patient rejected additional chemotherapy and died 8 months after the diagnosis.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Small Cell / diagnosis. Carcinoma, Squamous Cell / diagnosis. Urinary Bladder Neoplasms / diagnosis

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  • [Cites] Nihon Shokakibyo Gakkai Zasshi. 2001 Jan;98(1):53-7 [11201126.001]
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  • (PMID = 19390950.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Serpins; 0 / squamous cell carcinoma-related antigen
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63. Palacios A, Versos R, Massó P, Cavadas V, Soares J, Marcelo F: [Bladder exstrophy adenocarcinoma in an adult woman. Case report]. Arch Esp Urol; 2007 Mar;60(2):198-200
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  • [Title] [Bladder exstrophy adenocarcinoma in an adult woman. Case report].
  • [Transliterated title] Adenocarcinoma sobre extrofia vesical en mujer adulta. A propósito de un caso.
  • OBJECTIVE: To report a clinical case of bladder exstrophy adenocarcinoma.
  • The biopsy of the mass revealed bladder adenocarcinoma.
  • RESULTS: Pathologic study was compatible with moderately differentiated adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / complications. Bladder Exstrophy / complications. Urinary Bladder Neoplasms / complications
  • [MeSH-minor] Appendectomy. Female. Humans. Ileostomy. Lymph Node Excision. Middle Aged. Pelvic Exenteration. Surgical Wound Dehiscence. Thrombophlebitis / complications. Urinary Diversion. Uterine Cervicitis / complications

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  • (PMID = 17484491.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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64. Hayashi T, Ujike T, Yamamoto Y, Kamoto A, Nin M, Nishimura K, Miyoshi S, Kawano K: [Female urethral adenocarcinoma with urinary retention: a case report]. Hinyokika Kiyo; 2009 Jul;55(7):429-32
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  • [Title] [Female urethral adenocarcinoma with urinary retention: a case report].
  • A 57-year-old woman presented with urinary retention.
  • Intravenous pyelography demonstrated the filling defect of bladder.
  • Magnetic resonance imaging revealed the mass that had invaded bladder neck at dorsal side of urethra.
  • Pathological examination of transvaginal needle biopsy suggested well-differentiated adenocarcinoma.
  • Pathological diagnosis was urethral adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / complications. Urethral Neoplasms / complications. Urinary Retention / etiology

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  • (PMID = 19673433.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 13
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65. Kato M, Onishi T, Hoshina A, Yabana T: Successful treatment with paclitaxel/carboplatin chemotherapy in advanced adenocarcinoma of the urinary tract producing carcinoembryonic antigen, carbohydrate antigen 19-9 and carbohydrate antigen 125. Urol Int; 2010;84(1):116-8
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  • [Title] Successful treatment with paclitaxel/carboplatin chemotherapy in advanced adenocarcinoma of the urinary tract producing carcinoembryonic antigen, carbohydrate antigen 19-9 and carbohydrate antigen 125.
  • Primary adenocarcinoma of the urinary tract producing tumor markers is extremely rare.
  • We report 2 cases of advanced adenocarcinoma of the urinary tract producing carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9) and carbohydrate antigen 125 (CA125), which were completely resected after induction chemotherapy with paclitaxel and carboplatin.
  • Patient 1 was a 72-year-old woman with adenocarcinoma of the right renal pelvis and ureter.
  • Patient 2 was a 73-year-old woman with adenocarcinoma of the bladder.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. CA-125 Antigen / biosynthesis. CA-19-9 Antigen / biosynthesis. Carboplatin / administration & dosage. Carcinoembryonic Antigen / biosynthesis. Paclitaxel / administration & dosage. Urinary Bladder Neoplasms / drug therapy

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20173382.001).
  • [ISSN] 1423-0399
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / CA-125 Antigen; 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen; BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
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66. Heidrich DE: Delirium: an under-recognized problem. Clin J Oncol Nurs; 2007 Dec;11(6):805-7
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  • CASE STUDY: Ms. G, a 78-year-old woman with a history of heart failure and a left ventricular ejection fraction of 45%, had an exploratory laparotomy with colon resection and colostomy two days ago for an obstructive stage IIIB adenocarcinoma of the colon.
  • She has a patient-controlled analgesia (PCA) pump for postoperative pain control with 1 mg of morphine available every 30 minutes; she used a total of 4 mg of morphine via IV since midnight. Ms. G requires belladonna and opium suppositories about every eight hours to treat bladder spasms associated with her urinary catheter.
  • [MeSH-minor] Adenocarcinoma / surgery. Aged. Belladonna Alkaloids / adverse effects. Causality. Colonic Neoplasms / surgery. Colostomy / adverse effects. Early Diagnosis. Female. Humans. Morphine / adverse effects. Nursing Assessment. Opium / adverse effects. Pain, Postoperative / drug therapy. Pain, Postoperative / etiology. Postoperative Care / methods. Postoperative Care / nursing. Urinary Catheterization / adverse effects

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  • (PMID = 18063538.001).
  • [ISSN] 1092-1095
  • [Journal-full-title] Clinical journal of oncology nursing
  • [ISO-abbreviation] Clin J Oncol Nurs
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics, Opioid; 0 / Belladonna Alkaloids; 76I7G6D29C / Morphine; 8008-60-4 / Opium
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67. Hizli F, Berkmen F: Penile metastasis from other malignancies. A study of ten cases and review of the literature. Urol Int; 2006;76(2):118-21
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  • The rarity of the event prompted this study, which describes 10 cases of metastatic tumors of the penis including 7 cases with transitional cell carcinoma of the bladder, and in 1 case each of squamous cell carcinoma of the lung, adenocarcinoma of the prostate and leukemia.
  • The main characteristics of the primary tumor are described, along with the diagnosis, treatment and the outcome of patients.

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  • (PMID = 16493210.001).
  • [ISSN] 0042-1138
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 26
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68. Romero Otero J, Duarte Ojeda JM, Cruceyra Betriu G, Pérez-Martín ME, Sanchís Bonet A, Tejido Sánchez A, Leiva Galvis O: [Primary adenocarcinoma of the urinary bladder: our experience]. Actas Urol Esp; 2005 Mar;29(3):257-60
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  • [Title] [Primary adenocarcinoma of the urinary bladder: our experience].
  • [Transliterated title] Adenocarcinoma vesical primario: nuestra experiencia.
  • Adenocarcinoma of the bladder is an uncommon neoplasm.
  • Generally it grows to the density of the wall, so its clinical appearence is delayed, with the subsequent delayed diagnosis and although an agressive treatment is performed, it frequently has a very bad prognosis.
  • Since there are very few publications of this kind of neoplasm in the literature the lines of actuation in this pathology are not well established.
  • We report the eleven cases of adenocarcinoma neoplasm of the bladder treated in our centre and review the literature.
  • [MeSH-major] Adenocarcinoma
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Retrospective Studies. Urinary Bladder Neoplasms / diagnosis. Urinary Bladder Neoplasms / therapy

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  • (PMID = 15945250.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas espanolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 19
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69. Shanks JH, Iczkowski KA: Divergent differentiation in urothelial carcinoma and other bladder cancer subtypes with selected mimics. Histopathology; 2009 Jun;54(7):885-900
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  • [Title] Divergent differentiation in urothelial carcinoma and other bladder cancer subtypes with selected mimics.
  • Conventional urothelial carcinoma accounts for most carcinomas of the urinary tract lining.
  • Pure squamous carcinoma or adenocarcinoma (the latter in particular) can be difficult to distinguish from contiguous or metastatic spread.
  • Sarcomatoid carcinoma and its differential diagnosis with other spindle cell lesions of urinary tract will be covered in a separate review.
  • [MeSH-major] Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Clear Cell / diagnosis. Adenocarcinoma, Clear Cell / pathology. Adenoma / diagnosis. Adenoma / pathology. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / pathology. Carcinoma, Transitional Cell / diagnosis. Carcinoma, Transitional Cell / pathology. Cell Differentiation. Cystitis / diagnosis. Cystitis / pathology. Diagnosis, Differential. Giant Cell Tumors / diagnosis. Giant Cell Tumors / pathology. Humans. Neoplasm Metastasis / diagnosis. Neoplasm Metastasis / pathology. Neoplasms, Squamous Cell / diagnosis. Neoplasms, Squamous Cell / pathology. Neuroendocrine Tumors / diagnosis. Neuroendocrine Tumors / pathology. Radiation Injuries / diagnosis. Radiation Injuries / pathology. Urothelium / pathology

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  • (PMID = 19178589.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 152
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70. Bango García V, Luján Marco S, Bosquet Sanz M, Gimeno Argente V, Arlandis Guzmán S, Alonso Gorrea M, Jiménez Cruz F: [Primary bladder adenocarcinoma in unreconstructed exstrophic bladder]. Actas Urol Esp; 2009 Feb;33(2):197-9
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  • [Title] [Primary bladder adenocarcinoma in unreconstructed exstrophic bladder].
  • [Transliterated title] Adenocarcinoma vesical primario en extrofia vesical no corregida.
  • We report a 60-years-old patient with a not repaired exstrophic bladder, who develops an adenocarcinoma on his bladder and review of the literature.
  • [MeSH-major] Adenocarcinoma / complications. Bladder Exstrophy / complications. Urinary Bladder Neoplasms / complications

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  • (PMID = 19418846.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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71. Chaleoykitti B: Preoperative diagnosis of urinary bladder involvement in adenocarcinoma of colon and rectum. J Med Assoc Thai; 2005 Dec;88(12):1816-20
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  • [Title] Preoperative diagnosis of urinary bladder involvement in adenocarcinoma of colon and rectum.
  • OBJECTIVE: Objective of the study was to compare urinary symptoms, urinalysis, computed tomography, intravenous pyelography, ultrasonography between colorectal adenocarcinoma with urinary bladder involvement and without urinary bladder involvement.
  • MATERIAL AND METHOD: Patients with adenocarcinoma of the colon and rectum who had the first operation between January 1999 and October 2004 were included in the present study.
  • All patients were divided into the bladder adhesion group and nonadhesion group.
  • Sex, sites of tumor, urinary symptoms and preoperative investigations were compared.
  • 26 cases (5.7%) had bladder adhesion.
  • Males had more chance of having bladder involvement.
  • Sigmoid and rectum were the most common sites of bladder adhesion.
  • All cases with urinary symptoms had bladder involvement.
  • All cases whose computed tomography showed bladder involvement had bladder adhesion during surgery.
  • Ultrasonography and IVP did not help in detection of bladder invasion.
  • CONCLUSION: History of urinary symptoms, urinalysis, computed tomography should be routinely performed in patients with adenocarcinoma of the sigmoid and rectum to detect urinary bladder involvement and to inform modes of urinary tract diversion to patients before surgery.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Colonic Neoplasms / pathology. Rectal Neoplasms / pathology. Urinary Bladder Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Urinary Bladder / pathology. Urination Disorders / diagnosis. Urination Disorders / etiology

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  • (PMID = 16518979.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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72. Al-Mufarrej F, Kamel MH, Mohan P, Hickey D: Tricorporal priapism postradical cystoprostatectomy: first sign of recurrent urogenital malignancy. Int J Urol; 2006 Apr;13(4):460-2
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  • The disorder is frequently a manifestation of extensive pelvic extension of the primary disease; less commonly, it is associated with pelvic recurrence after seemingly curative surgery.
  • We report a case of proximal tricorporal priapism, secondary to penile metastasis of a bladder malignancy postradical cystoprostatectomy.
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Carcinoma, Transitional Cell / pathology. Carcinoma, Transitional Cell / surgery. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Invasiveness. Prostatic Neoplasms / pathology. Prostatic Neoplasms / surgery. Urinary Bladder Neoplasms / pathology. Urinary Bladder Neoplasms / surgery

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  • (PMID = 16734875.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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73. Pervez N, Small C, MacKenzie M, Yee D, Parliament M, Ghosh S, Mihai A, Amanie J, Murtha A, Field C, Murray D, Fallone G, Pearcey R: Acute toxicity in high-risk prostate cancer patients treated with androgen suppression and hypofractionated intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys; 2010 Jan 1;76(1):57-64
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  • [Title] Acute toxicity in high-risk prostate cancer patients treated with androgen suppression and hypofractionated intensity-modulated radiotherapy.
  • PURPOSE: To report acute toxicity resulting from radiotherapy (RT) dose escalation and hypofractionation using intensity-modulated RT (IMRT) treatment combined with androgen suppression in high-risk prostate cancer patients.
  • METHODS AND MATERIALS: Sixty patients with a histological diagnosis of high-risk prostatic adenocarcinoma (having either a clinical Stage of > or =T3a or an initial prostate-specific antigen [PSA] level of > or =20 ng/ml or a Gleason score of 8 to 10 or a combination of a PSA concentration of >15 ng/ml and a Gleason score of 7) were enrolled.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Prostatic Neoplasms / radiotherapy. Radiotherapy, Intensity-Modulated / adverse effects
  • [MeSH-minor] Aged. Aged, 80 and over. Androgen Antagonists / therapeutic use. Combined Modality Therapy. Dose Fractionation. Gastrointestinal Tract / radiation effects. Humans. Leuprolide / therapeutic use. Lymphatic Irradiation / adverse effects. Lymphatic Irradiation / methods. Male. Middle Aged. Pelvis. Prospective Studies. Prostate / radiation effects. Prostate-Specific Antigen / blood. Radiation Injuries / pathology. Rectum / radiation effects. Seminal Vesicles / radiation effects. Urinary Bladder / radiation effects. Urogenital System / radiation effects


74. El-Ghobashy A, Ohadike C, Wilkinson N, Lane G, Campbell JD: Recurrent urachal mucinous adenocarcinoma presenting as bilateral ovarian tumors on cesarean delivery. Int J Gynecol Cancer; 2009 Dec;19(9):1539-41
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  • [Title] Recurrent urachal mucinous adenocarcinoma presenting as bilateral ovarian tumors on cesarean delivery.
  • Metastases from the urinary tract are uncommon.
  • Primary adenocarcinoma of the bladder accounts for less than 1% of all bladder malignancies; one third of these tumors are urachal in origin.
  • Symptoms include hematuria, dysuria, frequency, urgency, and recurrent urinary tract infections.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Adenocarcinoma, Mucinous / diagnosis. Cesarean Section. Ovarian Neoplasms / diagnosis. Pregnancy Complications, Neoplastic / diagnosis. Urachus
  • [MeSH-minor] Adult. Delivery, Obstetric. Diagnosis, Differential. Female. Humans. Pregnancy


75. Agaimy A, Pelz AF, Wieacker P, Roessner A, Wünsch PH, Schneider-Stock R: Gastrointestinal stromal tumors of the vermiform appendix: clinicopathologic, immunohistochemical, and molecular study of 2 cases with literature review. Hum Pathol; 2008 Aug;39(8):1252-7
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  • Only 5 cases have been reported so far, all being 14 mm or less, and they have yet not been investigated at the molecular level.
  • Here, we report 2 appendiceal gastrointestinal stromal tumors in a 78-year-old woman and a 72-year-old man with a history of endometrial adenocarcinoma and urinary bladder carcinoma, respectively.
  • Both gastrointestinal stromal tumors were incidental findings at surgery for appendicitis-like symptoms and on follow-up for bladder carcinoma, respectively.

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  • (PMID = 18547614.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  • [Number-of-references] 21
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76. Higgins JP, Kaygusuz G, Wang L, Montgomery K, Mason V, Zhu SX, Marinelli RJ, Presti JC Jr, van de Rijn M, Brooks JD: Placental S100 (S100P) and GATA3: markers for transitional epithelium and urothelial carcinoma discovered by complementary DNA microarray. Am J Surg Pathol; 2007 May;31(5):673-80
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  • To identify novel diagnostic markers that may aid in the differential diagnosis of prostate versus urothelial carcinoma, we analyzed expression patterns in prostate and bladder cancer tissues using complementary DNA microarrays.
  • We conclude that the detection of S100P and GATA3 protein expression may help distinguish urothelial carcinomas from other genitourinary neoplasms that enter into the differential diagnosis.
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / metabolism. Calcium-Binding Proteins / metabolism. Carcinoma, Transitional Cell / metabolism. GATA3 Transcription Factor / metabolism. Neoplasm Proteins / metabolism. Urologic Neoplasms / metabolism
  • [MeSH-minor] Carcinoma, Renal Cell / genetics. Carcinoma, Renal Cell / metabolism. Carcinoma, Renal Cell / pathology. DNA, Neoplasm / analysis. Diagnosis, Differential. Female. Gene Expression Profiling. Humans. Immunohistochemistry. Kidney Neoplasms / genetics. Kidney Neoplasms / metabolism. Kidney Neoplasms / pathology. Male. Nephrectomy. Oligonucleotide Array Sequence Analysis. Prostatic Neoplasms / genetics. Prostatic Neoplasms / metabolism. Prostatic Neoplasms / pathology. Tissue Array Analysis. Urinary Bladder Neoplasms / genetics. Urinary Bladder Neoplasms / metabolism. Urinary Bladder Neoplasms / pathology. Urothelium / metabolism. Urothelium / pathology

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  • (PMID = 17460449.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Calcium-Binding Proteins; 0 / DNA, Neoplasm; 0 / GATA3 Transcription Factor; 0 / GATA3 protein, human; 0 / Neoplasm Proteins; 0 / S100P protein, human
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77. McCluggage WG, Shah R, Connolly LE, McBride HA: Intestinal-type cervical adenocarcinoma in situ and adenocarcinoma exhibit a partial enteric immunophenotype with consistent expression of CDX2. Int J Gynecol Pathol; 2008 Jan;27(1):92-100
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  • [Title] Intestinal-type cervical adenocarcinoma in situ and adenocarcinoma exhibit a partial enteric immunophenotype with consistent expression of CDX2.
  • Most cases of cervical adenocarcinoma in situ (AIS) and adenocarcinoma are of the usual or endocervical type.
  • However, intestinal types of AIS and adenocarcinoma exist.
  • With an intestinal-type adenocarcinoma in the cervix, the question may arise as to whether one is dealing with a primary cervical neoplasm or direct or secondary spread from an intestinal adenocarcinoma.
  • In organs such as the ovary, urinary bladder, esophagus, and gallbladder, intestinal-type glandular epithelium often expresses enteric markers, but this has hardly been studied in the cervix.
  • The purpose of this study was to investigate whether intestinal-type AIS and adenocarcinoma in the cervix express enteric markers and to ascertain whether these antibodies are of value in the distinction from a metastatic intestinal adenocarcinoma.
  • Cases included were AIS of usual type (n = 6), primary cervical adenocarcinoma of usual type (n = 6), AIS of intestinal type (n = 21), primary cervical adenocarcinoma of intestinal type (n = 3), primary cervical adenocarcinoma with signet ring cells (n = 2), and colorectal adenocarcinoma involving the cervix (n = 5).
  • The 3 cases of primary cervical intestinal-type adenocarcinoma were diffusely CK7 positive, focally or diffusely positive with CK20 and CDX2, and focally positive with CEA.
  • Intestinal types of cervical AIS and adenocarcinoma exhibit a partial enteric immunophenotype, usually with diffuse expression of CDX2 and, in some cases, staining with CK20.
  • Although there is immunophenotypic overlap, focal staining with CK20 together with diffuse CK7 and sometimes p16 positivity helps to distinguish intestinal types of cervical adenocarcinoma from involvement by a colorectal adenocarcinoma; CEA and CDX2 are of no value in this regard.
  • Using a set of cases of AIS diagnosed in a single institution over a 7-year period (77 usual type; 13 intestinal type), intestinal type was more likely to be associated with early invasive adenocarcinoma than usual type (31% vs 17%), suggesting that intestinal differentiation may be a risk factor for invasion in premalignant cervical glandular lesions.
  • [MeSH-major] Adenocarcinoma / metabolism. Homeodomain Proteins / biosynthesis. Intestinal Neoplasms / metabolism. Uterine Cervical Neoplasms / metabolism
  • [MeSH-minor] Biomarkers, Tumor / analysis. Carcinoembryonic Antigen / biosynthesis. Carcinoma in Situ / metabolism. Carcinoma in Situ / pathology. Cyclin-Dependent Kinase Inhibitor p16 / biosynthesis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Immunophenotyping. Keratin-20 / biosynthesis. Keratin-7 / biosynthesis

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  • (PMID = 18156982.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Carcinoembryonic Antigen; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Homeodomain Proteins; 0 / Keratin-20; 0 / Keratin-7
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78. Kagami S, Saeki H, Idezuki T, Yano S, Kawabata Y, Okochi H, Asahina A, Nakagawa K, Tamaki K: Epithelioid sarcoma associated with lung adenocarcinoma. J Dermatol; 2005 Nov;32(11):904-8
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  • [Title] Epithelioid sarcoma associated with lung adenocarcinoma.
  • His mother and father had died of rectal and bladder carcinoma, respectively, and he had also had a seminoma previously.
  • A lung biopsy revealed that he had well-differentiated adenocarcinoma which expressed p53.
  • Mutations in the TP53 gene were not searched for.
  • We selected conservative treatment because the patient did not want surgical wide resection or amputation.
  • The size of the ulcer and the tumor invasion along the fasciae of muscles were decreased, however, metastasis of the epithelioid sarcoma was detected in the lymph node of the left axilla four years after the diagnosis.
  • [MeSH-major] Adenocarcinoma / diagnosis. Lung Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Sarcoma / diagnosis. Skin Neoplasms / diagnosis


79. Lee TK, Chuang ST, Netto GJ: Conventional prostatic adenocarcinoma arising in a multilocular prostatic cystadenoma. Pathol Int; 2010 May;60(5):413-6
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  • [Title] Conventional prostatic adenocarcinoma arising in a multilocular prostatic cystadenoma.
  • Multilocular prostatic cystadenoma is a rare benign neoplasm located between the bladder and the rectum.
  • We report the first case of conventional prostatic adenocarcinoma involving a multilocular cystadenoma.
  • [MeSH-major] Adenocarcinoma / pathology. Cystadenoma / pathology. Neoplasms, Multiple Primary / pathology. Prostatic Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Cystadenocarcinoma / diagnosis. Diagnosis, Differential. Humans. Male. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 20518893.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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80. Schuurman JP, de Vries Reilingh TS, Roothaan SM, Bijleveld RT, Wiezer MJ: Urinary bladder metastasis from an esophageal adenocarcinoma: a case report. Am J Gastroenterol; 2009 Jun;104(6):1603-4
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  • [Title] Urinary bladder metastasis from an esophageal adenocarcinoma: a case report.
  • [MeSH-major] Adenocarcinoma / secondary. Esophageal Neoplasms / pathology. Urinary Bladder Neoplasms / secondary
  • [MeSH-minor] Diagnosis, Differential. Endoscopy, Gastrointestinal. Follow-Up Studies. Humans. Immunohistochemistry. Keratin-7 / analysis. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 19491880.001).
  • [ISSN] 1572-0241
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratin-7
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81. Emerson RE, Cheng L: Immunohistochemical markers in the evaluation of tumors of the urinary bladder: a review. Anal Quant Cytol Histol; 2005 Dec;27(6):301-16
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  • [Title] Immunohistochemical markers in the evaluation of tumors of the urinary bladder: a review.
  • The clinical utility of immunohistochemistry in the diagnosis of tumors of the urinary bladder is well established.
  • With recent advances in molecular biology and novel technologies, several biomarkers have emerged as important adjuncts in the diagnosis of lesions of the bladder.
  • When used in conjunction with careful histologic examination, immunohistochemistry can be a valuable aid in classifying adenocarcinoma presenting in the bladder and mesenchymal lesions of the bladder and in establishing the urothelial origin of a metastatic tumor.

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  • [CommentIn] Anal Quant Cytol Histol. 2007 Apr;29(2):121-2 [17484276.001]
  • [CommentIn] Anal Quant Cytol Histol. 2007 Dec;29(6):380-2 [18225396.001]
  • (PMID = 16450787.001).
  • [ISSN] 0884-6812
  • [Journal-full-title] Analytical and quantitative cytology and histology
  • [ISO-abbreviation] Anal. Quant. Cytol. Histol.
  • [Language] ENG
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 137
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82. Breivik KL, Laurini R, Steen R, Alstadhaug KB: [A 61-year-old man with sciatica]. Tidsskr Nor Laegeforen; 2009 May 14;129(10):1000-2
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  • On examination he had flaccid paraparesis and bladder-retention.
  • He became disoriented and died without a diagnosis.
  • Autopsy revealed a small adenocarcinoma of the lung and meningeal carcinomatosis originating from the adenocarcinoma.
  • [MeSH-major] Adenocarcinoma. Back Pain. Lung Neoplasms. Meningeal Carcinomatosis. Sciatica
  • [MeSH-minor] Autopsy. Cerebrospinal Fluid / cytology. Diagnosis, Differential. Fatal Outcome. Gait Disorders, Neurologic / diagnosis. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Paraparesis / diagnosis. Paresis / diagnosis. Pulmonary Fibrosis / pathology. Pulmonary Fibrosis / radiography

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  • [CommentIn] Tidsskr Nor Laegeforen. 2009 May 14;129(10):1002-3 [19448755.001]
  • (PMID = 19448754.001).
  • [ISSN] 0807-7096
  • [Journal-full-title] Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
  • [ISO-abbreviation] Tidsskr. Nor. Laegeforen.
  • [Language] nor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Norway
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83. Mhawech P, Greloz V, Assaly M, Herrmann F: Immunohistochemical expression of 14-3-3 sigma protein in human urological and gynecological tumors using a multi-tumor microarray analysis. Pathol Int; 2005 Feb;55(2):77-82
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  • The most frequent expression was seen in squamous cell carcinoma of the cervix and urothelial bladder carcinoma, followed by prostatic and endometrial adenocarcinoma.
  • 14-3-3 sigma was able to distinguish prostate adenocarcinoma from urothelial bladder carcinoma, with an odds ratio of 0.028 (P = 0.001; 95% CI, 0.0003-0.222), and distinguish seminoma from embryonal carcinoma of the testis, with an odds ratio of 0.061 (P = 0.009; 95% CI, 0.007-0.5014).
  • [MeSH-minor] 14-3-3 Proteins. Adenocarcinoma / diagnosis. Carcinoma, Embryonal / diagnosis. Carcinoma, Transitional Cell / diagnosis. Diagnosis, Differential. Exoribonucleases. Female. Humans. Male. Odds Ratio. Prostatic Neoplasms / diagnosis. Seminoma / diagnosis. Testicular Neoplasms / diagnosis. Urologic Neoplasms / diagnosis

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  • (PMID = 15693853.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / 14-3-3 Proteins; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; EC 3.1.- / Exonucleases; EC 3.1.- / Exoribonucleases; EC 3.1.- / SFN protein, human
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84. Castillo CM, Ha CY, Gater DR, Grob BM, Klausner AP: Prophylactic radical cystectomy for the management of keratinizing squamous metaplasia of the bladder in a man with tetraplegia. J Spinal Cord Med; 2007;30(4):389-91
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  • [Title] Prophylactic radical cystectomy for the management of keratinizing squamous metaplasia of the bladder in a man with tetraplegia.
  • BACKGROUND/OBJECTIVE: To report a case of keratinizing squamous metaplasia of the bladder treated with radical cystectomy.
  • METHODS: Keratinizing squamous metaplasia of the bladder is a rare entity that can result from chronic irritative stimuli involving the bladder.
  • A case report is presented describing the diagnosis and management of keratinizing squamous metaplasia of the bladder in a tetraplegic man with a chronic indwelling urinary catheter.
  • Final pathology revealed focal erosion and diffuse keratinizing squamous metaplasia of the bladder with prostatic adenocarcinoma as an incidental finding.
  • CONCLUSIONS: Patients with spinal cord injury who use indwelling catheters for bladder management are at higher risk of developing keratinizing squamous metaplasia.
  • An interdisciplinary approach is recommended before consideration of bladder resection.
  • [MeSH-major] Carcinoma, Squamous Cell / etiology. Carcinoma, Squamous Cell / surgery. Cystectomy / methods. Quadriplegia / complications. Urinary Bladder Neoplasms / etiology. Urinary Bladder Neoplasms / surgery

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  • (PMID = 17853664.001).
  • [ISSN] 1079-0268
  • [Journal-full-title] The journal of spinal cord medicine
  • [ISO-abbreviation] J Spinal Cord Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2031939
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85. Gerst SR, Touijer AK, Guillonneau B, Al-Ahmadie H, Mehdizade A: The importance of MRI evaluation in the preoperative work-up of prostate cancer. Nat Clin Pract Urol; 2005 Nov;2(11):565-71; quiz 572
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  • [Title] The importance of MRI evaluation in the preoperative work-up of prostate cancer.
  • DIAGNOSIS: Poorly differentiated adenocarcinoma of the prostate, with invasion of the urinary bladder.
  • [MeSH-major] Adenocarcinoma / diagnosis. Magnetic Resonance Imaging. Prostatic Neoplasms / diagnosis

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  • (PMID = 16474600.001).
  • [ISSN] 1743-4270
  • [Journal-full-title] Nature clinical practice. Urology
  • [ISO-abbreviation] Nat Clin Pract Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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86. Bannowsky A, Wefer B, Osmonov D, Sotelino JA, Filippow N, Naumann CM, van der Horst Ch, Jünemann KP, Hautmann S: [Mesonephroid carcinoma of the urinary bladder (clear cell carcinoma). Two case reports and review of the literature in a rare variation of the primary adenocarcinoma]. Aktuelle Urol; 2007 May;38(3):247-51
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  • [Title] [Mesonephroid carcinoma of the urinary bladder (clear cell carcinoma). Two case reports and review of the literature in a rare variation of the primary adenocarcinoma].
  • Mesonephroid adenocarcinoma of the bladder may be a malignant form of nephrogenic adenoma or nephroid metaplasia.
  • The lesion is extremely rare in the urinary bladder, and to our knowledge 19 cases have been reported in the literature.
  • We report two cases of mesonephroid adenocarcinoma of the bladder which were treated by radical cystectomy.
  • [MeSH-major] Mesonephroma / diagnosis. Urinary Bladder Neoplasms / diagnosis
  • [MeSH-minor] Aged. Cystectomy. Diagnosis, Differential. Disease Progression. Follow-Up Studies. Humans. Lymph Node Excision. Male. Middle Aged. Neoplasm Staging. Prostatectomy. Urinary Bladder / pathology. Urinary Reservoirs, Continent

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  • (PMID = 17516385.001).
  • [ISSN] 0001-7868
  • [Journal-full-title] Aktuelle Urologie
  • [ISO-abbreviation] Aktuelle Urol
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 21
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87. Mhawech-Fauceglia P, Zhang S, Terracciano L, Sauter G, Chadhuri A, Herrmann FR, Penetrante R: Prostate-specific membrane antigen (PSMA) protein expression in normal and neoplastic tissues and its sensitivity and specificity in prostate adenocarcinoma: an immunohistochemical study using mutiple tumour tissue microarray technique. Histopathology; 2007 Mar;50(4):472-83
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  • [Title] Prostate-specific membrane antigen (PSMA) protein expression in normal and neoplastic tissues and its sensitivity and specificity in prostate adenocarcinoma: an immunohistochemical study using mutiple tumour tissue microarray technique.
  • AIMS: To determine prostate-specific membrane antigen (PSMA) expression in normal tissues and in 3161 benign and malignant tumours and subsequently to define its sensitivity and specificity in prostatic adenocarcinoma (PaC).
  • Of 2174 various tumour types, 154 expressed PSMA, including 59/346 (17.0%) urothelial carcinomas of the bladder (UBC).
  • Furthermore, its sensitivity and specificity in differentiating PaC from urothelial cancer is 65.9% and 82.9%, respectively.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / metabolism. Female. Humans. Immunohistochemistry. Male. Organ Specificity. Prostate / metabolism. Prostatic Neoplasms / diagnosis. Prostatic Neoplasms / metabolism. Reference Values. Sensitivity and Specificity. Tissue Array Analysis

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  • (PMID = 17448023.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Surface; EC 3.4.17.21 / Glutamate Carboxypeptidase II; EC 3.4.17.21 / glutamate carboxypeptidase II, human
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88. Sugimori K, Kobayashi K, Hayashi M, Sakai N, Sasaki M, Koshino Y: Leptomeningeal carcinomatosis from urinary bladder adenocarcinoma: a clinicopathological case study. Neuropathology; 2005 Mar;25(1):89-94
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  • [Title] Leptomeningeal carcinomatosis from urinary bladder adenocarcinoma: a clinicopathological case study.
  • We report a 73-year-old male patient with leptomeningeal metastasis from urinary bladder adenocarcinoma.
  • Meningeal carcinomatosis was detected 5 days before his death, but the primary site of the malignant tumor could not be determined.
  • Necropsy revealed leptomeningeal infiltration of many adenocarcinoma cells that covered the cerebrum.
  • Meningeal carcinomatosis from urinary bladder adenocarcinoma is extremely rare and up-regulation of the adhesion molecules in the meningeal adenocarcinoma was confirmed.
  • [MeSH-major] Adenocarcinoma / secondary. Meningeal Neoplasms / secondary. Urinary Bladder Neoplasms / pathology

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  • (PMID = 15822823.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Vascular Cell Adhesion Molecule-1; 68238-35-7 / Keratins
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89. Kobayashi S, Tsukamoto T, Tohsaka A, Tohma T: [Estramustine phosphate withdrawal syndrome in relapsed prostate cancer: two case reports]. Hinyokika Kiyo; 2008 Jun;54(6):423-6
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  • [Title] [Estramustine phosphate withdrawal syndrome in relapsed prostate cancer: two case reports].
  • He was diagnosed with prostate cancer with multiple bone metastases.
  • Transurethral bladder biopsy and transrectal prostate biopsy were performed.
  • The diagnosis was moderately differentiated adenocarcinoma of the prostate that invaded to the bladder.
  • [MeSH-minor] Adenocarcinoma / drug therapy. Aged. Humans. Male. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 18634439.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 35LT29625A / Estramustine
  • [Number-of-references] 8
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90. Prieto MC, Matousek P, Towrie M, Parker AW, Wright M, Ritchie AW, Stone N: Use of picosecond Kerr-gated Raman spectroscopy to suppress signals from both surface and deep layers in bladder and prostate tissue. J Biomed Opt; 2005 Jul-Aug;10(4):44006
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  • [Title] Use of picosecond Kerr-gated Raman spectroscopy to suppress signals from both surface and deep layers in bladder and prostate tissue.
  • Prostate samples for this study were obtained by taking a chip at the transurethral resection of the prostate (TURP), and bladder samples from a biopsy taken at transurethral resection of bladder tumor (TURBT) and TURP.
  • Spectra obtained through the bladder and prostate gland tissue, at different time delays after the laser pulse, clearly show change in the spectra as depth profiling occurs, eventually showing signals from the uric acid cell and urea cell, respectively.
  • We show for the first time, using this novel technique, that we are able to obtain spectra from different depths through both the prostate gland and the bladder.
  • This has major implications in the future of Raman spectroscopy as a tool for diagnosis.
  • With the help of Raman spectroscopy and Kerr gating, it may be possible to pick up the spectral differences from a small focus of adenocarcinoma of the prostate gland in an otherwise benign gland, and also stage the bladder cancers by assessing the base of the tumor post resection.
  • [MeSH-major] Biomarkers, Tumor / analysis. Prostatic Neoplasms / chemistry. Prostatic Neoplasms / diagnosis. Spectrum Analysis, Raman / methods. Urinary Bladder Neoplasms / chemistry. Urinary Bladder Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / chemistry. Adenocarcinoma / diagnosis. Algorithms. Artifacts. Humans. Male. Reproducibility of Results. Sensitivity and Specificity

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  • (PMID = 16178640.001).
  • [ISSN] 1083-3668
  • [Journal-full-title] Journal of biomedical optics
  • [ISO-abbreviation] J Biomed Opt
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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91. Siefker-Radtke A: Urachal carcinoma: surgical and chemotherapeutic options. Expert Rev Anticancer Ther; 2006 Dec;6(12):1715-21
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  • The urachal ligament is an embryologic remnant connecting the dome of the bladder to the umbilicus via the ligamentum commune.
  • Patients usually present with hematuria and upon imaging, have evidence of a cystic or solid structure in the bladder dome or in the bladder midline.
  • If a biopsy confirms adenocarcinoma, these tumors should be considered an urachal cancer until proven otherwise.
  • Unfortunately, there are many patients who present with metastatic disease that currently is not likely to be curable.
  • [MeSH-major] Adenocarcinoma / therapy. Cystectomy / methods. Urachus / pathology. Urinary Bladder Neoplasms / therapy
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Transitional Cell / diagnosis. Carcinoma, Transitional Cell / pathology. Cisplatin / administration & dosage. Clinical Trials as Topic. Clinical Trials, Phase II as Topic. Combined Modality Therapy. Deoxycytidine / administration & dosage. Deoxycytidine / analogs & derivatives. Diagnosis, Differential. Female. Fluorouracil / administration & dosage. Hematuria / etiology. Humans. Leucovorin / administration & dosage. Male. Middle Aged. Neoplasm Staging. Prospective Studies. Risk Factors. Umbilicus / surgery. Urachal Cyst / pathology. Urachal Cyst / surgery

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  • (PMID = 17181485.001).
  • [ISSN] 1744-8328
  • [Journal-full-title] Expert review of anticancer therapy
  • [ISO-abbreviation] Expert Rev Anticancer Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine; Q20Q21Q62J / Cisplatin; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
  • [Number-of-references] 29
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92. Manassero F, Giannarini G, Paperini D, Mogorovich A, Alì G, Boggi U, Selli C: Simultaneous penile and signet ring cell bladder carcinoma in renal transplant recipient: a first case. ScientificWorldJournal; 2009;9:920-3
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  • [Title] Simultaneous penile and signet ring cell bladder carcinoma in renal transplant recipient: a first case.
  • The incidence and prevalence of cancer increase with time after transplantation.
  • The first case presented is one of a 65-year-old patient with a double genitourinary carcinoma (penis and bladder).
  • After adequate surgical treatment (partial amputation of the penis for squamous cell carcinoma and complete transurethral resection of bladder adenocarcinoma), the patient was noted to be free of tumor recurrence and had functioning renal graft with a 2-year follow-up.
  • [MeSH-major] Carcinoma, Signet Ring Cell / pathology. Kidney Transplantation / adverse effects. Penile Neoplasms / pathology. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Aged. Humans. Male. Urinary Bladder / pathology


93. Eissa S, Zohny SF, Zekri AR, El-Zayat TM, Maher AM: Diagnostic value of fibronectin and mutant p53 in the urine of patients with bladder cancer: impact on clinicopathological features and disease recurrence. Med Oncol; 2010 Dec;27(4):1286-94
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  • [Title] Diagnostic value of fibronectin and mutant p53 in the urine of patients with bladder cancer: impact on clinicopathological features and disease recurrence.
  • Development of new methods for bladder cancer detection is required because cystoscopy is invasive, and voided urine cytology (VUC) has low sensitivity.
  • The aim of this study was to evaluate the diagnostic performance of urinary fibronectin and mutant p53 in comparison with VUC in the detection of bladder cancer.
  • This study included 100 patients diagnosed with bladder cancer, 93 patients with benign urological disorders and 47 healthy volunteers.
  • Our results indicate that fibronectin had the highest sensitivity compared to VUC and mutant p53 in bladder cancer detection; however, mutant p53 had superior specificity compared to VUC and fibronectin.
  • Mutant p53 is associated with disease recurrence and hence it has a significant prognostic role in bladder cancer.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Transitional Cell / diagnosis. Fibronectins / urine. Mutation / genetics. Tumor Suppressor Protein p53 / genetics. Urinary Bladder Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Animals. Biomarkers, Tumor / genetics. Biomarkers, Tumor / urine. Case-Control Studies. Cystoscopy. Female. Follow-Up Studies. Humans. Immunoenzyme Techniques. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / genetics. Neoplasm Recurrence, Local / urine. Neoplasm Staging. Polymerase Chain Reaction. Prognosis. ROC Curve. Schistosoma mansoni / pathogenicity. Schistosomiasis / diagnosis. Schistosomiasis / genetics. Schistosomiasis / urine. Sensitivity and Specificity. Survival Rate. Urinary Bladder / metabolism. Urinary Bladder / pathology

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  • (PMID = 20012564.001).
  • [ISSN] 1559-131X
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Fibronectins; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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94. Castellan M, Gosalbez R, Perez-Brayfield M, Healey P, McDonald R, Labbie A, Lendvay T: Tumor in bladder reservoir after gastrocystoplasty. J Urol; 2007 Oct;178(4 Pt 2):1771-4; discussion 1774
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  • [Title] Tumor in bladder reservoir after gastrocystoplasty.
  • PURPOSE: To our knowledge the risk of malignancy in patients with previous bladder augmentation with stomach is unknown.
  • We report 3 cases of gastric adenocarcinoma and 1 of transitional cell carcinoma after augmentation cystoplasty with stomach with long-term followup.
  • Preoperative diagnosis was neurogenic bladder in 3 patients and posterior urethral valve in 1.
  • Three patients had gastric adenocarcinoma, while the other had poorly differentiated transitional cell carcinoma.
  • CONCLUSIONS: Patients who undergo bladder augmentation with a gastric remnant are at increased risk for malignancy, probably similar to that in patients with enterocystoplasty.
  • Patients should be followed annually with ultrasound, and cystoscopy should be performed annually starting 10 years after gastrocystoplasty unless they have abnormal ultrasound, hematuria or another cancer risk factor.
  • [MeSH-major] Adenocarcinoma / etiology. Carcinoma, Transitional Cell / etiology. Gastric Mucosa / transplantation. Urinary Bladder Neoplasms / etiology. Urinary Diversion / adverse effects. Urinary Reservoirs, Continent / adverse effects
  • [MeSH-minor] Adolescent. Adult. Child. Humans. Male. Retrospective Studies. Risk Factors. Urinary Bladder / surgery. Urodynamics

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  • (PMID = 17707009.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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95. Singh I, Hudson JE, Hemal AK: Robot-assisted laparoscopic prostatectomy for a giant prostate with retrieval of vesical stones. Int Urol Nephrol; 2010 Sep;42(3):615-9
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  • RESULTS: An elderly, male with a BMI of 32.49, clinically diagnosed as a case of giant BPH (prior negative prostate biopsy) with vesical stones and severe LUTS, was successfully managed by modified robot assisted laparoscopic technique of prostatectomy with removal of bladder stones.
  • The final histology was predominant BPH with an incidental focal adenocarcinoma within the distal left prostate.
  • Minimally invasive management of massively enlarged prostate with associated bladder stones is a challenging task.
  • The present case of giant prostate enlargement (incidental localized prostate cancer) with vesical stones was successfully managed by a combination of robotic prostatectomy and removal of bladder stones under flexible endoscopic guidance.
  • To the best of our knowledge the present case is the largest (384 g) reported case of cancer prostate (concomitant vesical stone), to be removed by minimally invasive robot assisted laparoscopic technique in the English literature (PubMed™).
  • [MeSH-major] Laparoscopy. Prostatectomy. Prostatic Hyperplasia / surgery. Robotics. Urinary Bladder Calculi / surgery
  • [MeSH-minor] Aged. Cystoscopy. Humans. Incidental Findings. Male. Prostate / pathology. Prostatic Neoplasms / diagnosis


96. Rieder JM, Parsons JK, Gearhart JP, Schoenberg M: Primary squamous cell carcinoma in unreconstructed exstrophic bladder. Urology; 2006 Jan;67(1):199
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  • [Title] Primary squamous cell carcinoma in unreconstructed exstrophic bladder.
  • Bladder exstrophy is associated with an increased incidence of primary adenocarcinoma of the bladder.
  • We report a rare case of squamous cell carcinoma occurring in the unreconstructed, exstrophic bladder of a 53-year-old woman treated with radical cystectomy and radiochemotherapy.
  • This case represents the oldest patient to present with squamous cell carcinoma of an unreconstructed exstrophic bladder.
  • We discuss the potential mechanisms of carcinogenesis in this patient, noting how they may potentially differ from those in a patient with a reconstructed bladder.
  • [MeSH-major] Bladder Exstrophy / complications. Carcinoma, Squamous Cell / complications. Urinary Bladder Neoplasms / complications

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  • (PMID = 16413365.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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97. Cruz-Gonzáles GH, Sánchez-Salas RE, Palmer-Román KJ, Sánchez-Rivero FR, Sánchez-Salas R, Daboin I, Mota D, León A: [Primary signet ring cell bladder adenocarcinoma. Case report with a multidisciplinary therapeutical approach]. Actas Urol Esp; 2007 Sep;31(8):919-22
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  • [Title] [Primary signet ring cell bladder adenocarcinoma. Case report with a multidisciplinary therapeutical approach].
  • [Transliterated title] Adenocarcinoma en células en anillo de sello primario de vejiga. Presentación de un caso clínico con tratamiento multidisciplinario.
  • INTRODUCTION: Bladder carcinoma is the second most frequent genitourinary tumor.
  • Adenocarcinoma accounts for up to 0.5 to 2% of bladder carcinoma types.
  • The pathology states the bladder adenocarcinomas are mucous secreting lesions with glandular, colloid or signet ring cell patterns.
  • Even the important advances reached in the field of bladder carcinoma, yet less frequent lesions as bladder adenocarcinoma do not have a standarized treatment protocol.
  • METHODS: Case report of a patient with primary signet ring cell bladder adenocarcinoma with a therapeutical multidisciplinary approach.
  • CONCLUSIONS: Bladder adenocarcionoma is a rare oncological entity.
  • [MeSH-major] Carcinoma, Signet Ring Cell. Urinary Bladder Neoplasms

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  • (PMID = 18020218.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas espanolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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98. Kaufman DS, Shipley WU, Feldman AS: Bladder cancer. Lancet; 2009 Jul 18;374(9685):239-49
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bladder cancer.
  • Bladder cancer is a heterogeneous disease, with 70% of patients presenting with superficial tumours, which tend to recur but are generally not life threatening, and 30% presenting as muscle-invasive disease associated with a high risk of death from distant metastases.
  • The main presenting symptom of all bladder cancers is painless haematuria, and the diagnosis is established by urinary cytology and transurethral tumour resection.
  • The standard of care for muscle-invasive disease is radical cystoprostatectomy, and several types of urinary diversions are offered to patients, with quality of life as an important consideration.
  • Bladder preservation with transurethral tumour resection, radiation, and chemotherapy can in some cases be equally curative.
  • We discuss bladder preserving approaches, combination chemotherapy including new agents, targeted therapies, and advances in molecular biology.
  • [MeSH-major] Urinary Bladder Neoplasms
  • [MeSH-minor] Adenocarcinoma / epidemiology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Transitional Cell / epidemiology. Chemotherapy, Adjuvant. Combined Modality Therapy. Cystectomy. Cystoscopy. Diagnosis, Differential. Hematuria / etiology. Humans. Molecular Biology. Neoadjuvant Therapy. Neoplasm Staging. Prostatectomy. Risk Factors. Sensitivity and Specificity. Survival Rate. United States / epidemiology. Urinary Diversion


99. Girgin C, Oder M, Sahin MO, Sezer A, Berkmen S, Aydin R, Dincel C: Erection- and ejaculation-preserving cystectomy with orthotopic urinary diversion: is it feasible? J Androl; 2006 Mar-Apr;27(2):263-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Erection- and ejaculation-preserving cystectomy with orthotopic urinary diversion: is it feasible?
  • Of the cases, 3 patients had pT1 G3 transitional cell carcinoma (TCC) refractory to treatment and one had pT2a adenocarcinoma of the bladder.
  • Extirpation of the bladder and anterior proximal prostate en bloc with preservation of the vasa deferentia, seminal vesicles, posterior prostate, and neurovascular bundles was performed after pelvic lymphadenectomy.
  • [MeSH-major] Cystectomy / adverse effects. Ejaculation / physiology. Fertility / physiology. Penile Erection / physiology. Urinary Diversion / methods
  • [MeSH-minor] Adult. Female. Humans. Male. Urinary Incontinence

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  • (PMID = 16304209.001).
  • [ISSN] 0196-3635
  • [Journal-full-title] Journal of andrology
  • [ISO-abbreviation] J. Androl.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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100. Zaghloul MS, El Baradie M, Nouh, Abdel-Fatah S, Taher A, Shalaan M: Prognostic index for primary adenocarcinoma of the urinary bladder. Gulf J Oncolog; 2007 Jul;(2):47-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic index for primary adenocarcinoma of the urinary bladder.
  • AIM: To determine the working independent prognostic factors and the prognostic index of adenocarcinoma of the urinary bladder.
  • PATIENTS AND METHODS: Two hundred and sixteen patients having adenocarcinoma of the urinary bladder were treated with radical cystectomy and pelvic lymphadenectomy with (82 patients) or without (134) postoperative radiotherapy.
  • CONCLUSIONS: The identified prognostic indices with their prognostic group could be used not only as a predictor of disease-free survival but also as a good predictor for the need to add adjuvant therapy in adenocarcinoma of the urinary bladder.
  • [MeSH-major] Adenocarcinoma / diagnosis. Urinary Bladder Neoplasms / diagnosis

  • MedlinePlus Health Information. consumer health - Bladder Cancer.
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  • (PMID = 20084724.001).
  • [ISSN] 2078-2101
  • [Journal-full-title] The Gulf journal of oncology
  • [ISO-abbreviation] Gulf J Oncolog
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Kuwait
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