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1. Vidarsdottir H, Moller PH, Benediktsdottir KR, Geirsson G: Adenocarcinoma of the appendix with a fistula to the urinary bladder. Scand J Urol Nephrol; 2010 Nov;44(5):354-6
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  • [Title] Adenocarcinoma of the appendix with a fistula to the urinary bladder.
  • Adenocarcinoma of the vermiform appendix is a rare disease that constitutes less than 0.5% of all gastrointestinal malignancies.
  • She was diagnosed with adenocarcinoma of the appendix with a fistula to the urinary bladder.
  • [MeSH-major] Adenocarcinoma / complications. Appendiceal Neoplasms / complications. Urinary Fistula / etiology

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  • (PMID = 20509819.001).
  • [ISSN] 1651-2065
  • [Journal-full-title] Scandinavian journal of urology and nephrology
  • [ISO-abbreviation] Scand. J. Urol. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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2. Djuranovic SP, Spuran MM, Kovacevic NV, Ugljesic MB, Kecmanovic DM, Micev MT: Mucinous cystadenoma of the appendix associated with adenocarcinoma of the sigmoid colon and hepatocellular carcinoma of the liver: report of a case. World J Gastroenterol; 2006 Mar 28;12(12):1975-7
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  • [Title] Mucinous cystadenoma of the appendix associated with adenocarcinoma of the sigmoid colon and hepatocellular carcinoma of the liver: report of a case.
  • Mucinous cystadenoma of the appendix is a rare condition and represents one of the three entities with the common name mucocele of the appendix.
  • This condition is often associated with other neoplasia, especially adenocarcinoma of the colon and ovaries.
  • He had a big cystadenoma of the appendix associated with adenocarcinoma of the colon and hepatocellular carcinoma of the liver.
  • According to this, we stress the need of accurate preoperative diagnosis and intraoperative exploration of the whole abdomen in these patients.
  • [MeSH-major] Adenocarcinoma / complications. Appendiceal Neoplasms / complications. Carcinoma, Hepatocellular / complications. Cystadenoma, Mucinous / complications. Liver Neoplasms / complications. Sigmoid Neoplasms / complications

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  • (PMID = 16610012.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4087531
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3. Oya S, Miyata K, Yuasa N, Takeuchi E, Goto Y, Miyake H, Nagasawa K, Kobayashi Y, Ito T, Ito M: Early carcinoma of the appendix vermiformis. Dig Endosc; 2009 Jan;21(1):53-5
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  • [Title] Early carcinoma of the appendix vermiformis.
  • It is difficult to preoperatively diagnose early carcinoma of the vermiform appendix because of its rarity and few specific clinical features.
  • In the present study, we report a preoperatively diagnosed mucosal carcinoma of the vermiform appendix.
  • [MeSH-major] Adenocarcinoma / diagnosis. Appendiceal Neoplasms / diagnosis

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  • (PMID = 19691804.001).
  • [ISSN] 1443-1661
  • [Journal-full-title] Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
  • [ISO-abbreviation] Dig Endosc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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4. McGory ML, Maggard MA, Kang H, O'Connell JB, Ko CY: Malignancies of the appendix: beyond case series reports. Dis Colon Rectum; 2005 Dec;48(12):2264-71
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  • [Title] Malignancies of the appendix: beyond case series reports.
  • PURPOSE: A comprehensive analysis was performed for five histologic types of appendiceal tumors to compare incidence, clinicopathologic features, survival, and appropriateness of surgery.
  • METHODS: All patients diagnosed with mucinous adenocarcinoma (n = 951), adenocarcinoma (n = 646), carcinoid (n = 435), goblet (n = 369), and signet-ring cell (n = 113) in the Surveillance, Epidemiology, and End Results database (1973-2001) were analyzed.
  • RESULTS: Tumor incidence, patient demographics, survival outcomes, and appropriateness of surgery varied significantly among the different appendiceal tumor histologies.
  • The most common appendiceal tumors were mucinous.
  • CONCLUSIONS: This study provides a population-based analysis of epidemiology, tumor characteristics, survival, and quality of care for appendiceal carcinomas.
  • This characterization provides a novel description of the presentation and outcomes for malignancies of the appendix and highlights that a substantial number of patients with appendiceal tumors may not be receiving appropriate surgical resection.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Carcinoma, Signet Ring Cell / pathology

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  • (PMID = 16258711.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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5. Suzuki O, Ono K, Sekishita Y, Fujimori M, Shiono T, Kondo S: Laparoscopic two-stage surgery for goblet cell carcinoid of the appendix: report of a case and review of the Japanese literature. Surg Laparosc Endosc Percutan Tech; 2006 Apr;16(2):106-8
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  • [Title] Laparoscopic two-stage surgery for goblet cell carcinoid of the appendix: report of a case and review of the Japanese literature.
  • Goblet cell carcinoid of the appendix is a rare clinical entity exhibiting features of both carcinoid and adenocarcinoma.
  • A 49-year-old man underwent laparoscopic appendectomy under the diagnosis of acute appendicitis.
  • A pathologic diagnosis of goblet cell carcinoid, accompanied by the aggressive proliferation, with acute appendicitis was made.
  • Subsequent laparoscopic ileocecal resection was performed, and it was verified that there were neither residual tumor nor lymph node metastases.
  • [MeSH-major] Appendectomy / methods. Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery. Colectomy / methods. Laparoscopy / methods
  • [MeSH-minor] Anastomosis, Surgical / methods. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Middle Aged

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  • (PMID = 16773013.001).
  • [ISSN] 1530-4515
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. Rojo Sebastián A, Fernández Morejón FJ, Bretcha Boix P, Farré Alegre J, Forteza Vila J, Brugarolas Masllorens A: Controversial origin of Pseudomyxoma peritonei. Clin Transl Oncol; 2006 Oct;8(10):767-9
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  • The main diagnostic problem appears when the primary site of origin could be appendix or ovary.
  • In this paper describe clinicopathological features and biological markers that support appendiceal origin.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology. Ovarian Neoplasms / pathology. Peritoneal Neoplasms / etiology. Pseudomyxoma Peritonei / etiology
  • [MeSH-minor] Aged. Appendix / pathology. Diagnosis, Differential. Female. Humans. Ovary / pathology. Peritoneum / pathology. Prognosis

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  • (PMID = 17074679.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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7. Kurian RR, Prema NS, Belthazar A: Paratesticular papillary serous cystadenocarcinoma--a case report. Indian J Pathol Microbiol; 2006 Jan;49(1):36-7
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  • They are thought to arise from Mullerian metaplasia of the peritoneal lining of the tunica vaginalis, appendix testis or mullerian remnants between the testis and spermatic cord.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Cystadenocarcinoma, Serous / pathology. Testicular Neoplasms / pathology. Testis / pathology

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  • (PMID = 16625973.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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8. Uharcek P, Mlyncek M, Durcanský D: Appendiceal adenocarcinoma presenting with bilateral Krukenberg tumors. J Obstet Gynaecol Res; 2007 Apr;33(2):211-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appendiceal adenocarcinoma presenting with bilateral Krukenberg tumors.
  • Primary appendiceal malignancy metastatic to the ovaries is a condition that may mimic advanced stage ovarian cancer.
  • A 52-year-old woman referred to our institution for presumed advanced stage of ovarian cancer was found to have primary appendiceal adenocarcinoma metastatic to ovaries at laparotomy.
  • It is important for the gynecologist-oncologist to include tumors of the appendix into the differential diagnosis of any case of ovarian tumor.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Krukenberg Tumor / secondary. Ovarian Neoplasms / secondary

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  • (PMID = 17441899.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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9. Alsaad KO, Serra S, Chetty R: Combined goblet cell carcinoid and mucinous cystadenoma of the vermiform appendix. World J Gastroenterol; 2009 Jul 21;15(27):3431-3
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  • [Title] Combined goblet cell carcinoid and mucinous cystadenoma of the vermiform appendix.
  • Goblet cell carcinoid is an uncommon primary tumor of the vermiform appendix, characterized by dual endocrine and glandular differentiation.
  • Whether goblet cell carcinoid represents a morphological variant of appendiceal classical carcinoid or a mucin-producing adenocarcinoma is a matter of conjecture.
  • Rare cases of goblet cell carcinoid with other concomitant appendiceal epithelial neoplasms have been documented.
  • In this report, we describe a rare case of combined appendiceal goblet cell carcinoid and mucinous cystadenoma, and discuss the possible histopathogenesis of this combination.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Appendix / pathology. Carcinoid Tumor / pathology. Cystadenoma, Mucinous / pathology

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  • (PMID = 19610147.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2712907
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10. Huang B, Di MJ, Liu HS, Qiu LL, Sun LJ, Xu JP: [Primary malignant tumor of the appendix: clinicopathological analysis of 22 cases]. Zhejiang Da Xue Xue Bao Yi Xue Ban; 2009 Mar;38(2):194-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary malignant tumor of the appendix: clinicopathological analysis of 22 cases].
  • OBJECTIVE: To investigate the clinicopathological and immunohistochemical features of primary malignant tumor of the appendix.
  • METHODS: The clinical data were reviewed; and histopathological and immunohistochemical features were analyzed in 22 cases with primary malignant tumor of the appendix.
  • RESULT: In 22 cases of primary malignant tumor of the appendix, 19 cases were carcinoid and 3 were adenocarcinoma.
  • Immunohistochemistry showed that the carcinoid was positively reacted to the neuroendocrine markers, and the adenocarcinoma was negatively reacted to the neuroendocrine markers.
  • CONCLUSION: Immunohistochemistry is useful in diagnosis of primary malignant tumor of the appendix, a rare type of cancer.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adolescent. Adult. Aged. Female. Humans. Immunohistochemistry. Male. Middle Aged. Young Adult

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  • (PMID = 19363829.001).
  • [ISSN] 1008-9292
  • [Journal-full-title] Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
  • [ISO-abbreviation] Zhejiang Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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11. Matsui H, Igarashi N, Okamura A, Itano O, Koyama Y, Miyakita M: Laparoscopy-assisted resection of an appendiceal mucinous cystadenoma. Tokai J Exp Clin Med; 2007 Dec;32(4):140-3
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  • [Title] Laparoscopy-assisted resection of an appendiceal mucinous cystadenoma.
  • We present a 48-year-old man with a complaint of dull right-lower abdominal pain who was diagnosed with mucocele of the appendix.
  • In the procedure, the entire right colon was freed from the retroperitoneal structures without rupturing the tumor; and ileocecal resection and anastomosis were performed extracorporeally.
  • The pathological diagnosis of the tumor was mucinous cystadenoma of the appendix, measuring 9.0 cm × 8.0 cm × 4.0 cm.
  • When resecting an appendiceal mucinous tumor laparoscopically, it is essential (1) to keep the tumor intact during manipulation, and to use a wound-protecting device when delivering the lesion;.
  • (2) to consider the extent of tumor resection with a negative surgical margin as well as prophylactic lymph node dissection in cases of suspected adenocarcinoma, even though the oncological adequacy of the laparoscopic procedure for carcinoma remains to be elucidated; and (3) to check whether any mucinous fluid has accumulated in the abdominal cavity, which represents an indication for open surgery.
  • [MeSH-major] Appendiceal Neoplasms / surgery. Cystadenoma, Mucinous / surgery. Laparoscopy / methods

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  • (PMID = 21318954.001).
  • [ISSN] 2185-2243
  • [Journal-full-title] The Tokai journal of experimental and clinical medicine
  • [ISO-abbreviation] Tokai J. Exp. Clin. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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12. Tang LH, Shia J, Soslow RA, Dhall D, Wong WD, O'Reilly E, Qin J, Paty P, Weiser MR, Guillem J, Temple L, Sobin LH, Klimstra DS: Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix. Am J Surg Pathol; 2008 Oct;32(10):1429-43
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  • [Title] Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix.
  • Appendiceal tumors exhibiting both neuroendocrine and glandular differentiation are uncommon and have caused difficulty in pathologic classification, prediction of prognosis, and clinical management.
  • Previously, such lesions have been variously designated as adenocarcinoid, goblet cell carcinoid (GCC), and mixed adenocarcinoma carcinoid.
  • In this study, we undertook a retrospective investigation of 63 such cases and classified them as typical GCC (group A) and adenocarcinoma ex GCC on the basis of the histologic features of the tumor at the primary site.
  • The adenocarcinoma ex GCC group was further divided into signet ring cell type (group B) and poorly differentiated adenocarcinoma type (group C).
  • The clinical characteristics and prognosis were compared within these groups and with conventional de novo appendiceal adenocarcinomas.
  • In conclusion, GCC is a distinctive appendiceal neoplasm that exhibits unique pathologic features and clinical behavior.
  • They display a spectrum of histologic features and possess the potential to transform to an adenocarcinoma phenotype of either signet ring cell or poorly differentiated adenocarcinoma types.
  • Surgical management with right hemicolectomy is recommended after appendectomy for most cases, particularly those with an adenocarcinoma component (groups B and C).
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Carcinoma, Signet Ring Cell / pathology


13. Dupre MP, Jadavji I, Matshes E, Urbanski SJ: Diverticular disease of the vermiform appendix: a diagnostic clue to underlying appendiceal neoplasm. Hum Pathol; 2008 Dec;39(12):1823-6
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  • [Title] Diverticular disease of the vermiform appendix: a diagnostic clue to underlying appendiceal neoplasm.
  • Acquired diverticula of the vermiform appendix are rare and arise as a result of different pathogenetic mechanisms.
  • Although the association of appendiceal diverticulosis and neoplasia is known, it remains underemphasized in the teaching and practice of surgical pathology.
  • To investigate the frequency of appendiceal neoplasms with acquired diverticulosis, we conducted a retrospective analysis of all appendectomy specimens received in our institution for a 55-month period (January 2002-July 2006).
  • Eleven (48%) appendectomy specimens with diverticulosis also harbored an appendiceal neoplasm.
  • The association of appendiceal neoplasms with diverticulosis was statistically significant (P < .0001, 2-sided Fisher exact test).
  • We stress the need for meticulous gross assessment with histologic examination of the entire appendectomy specimen in cases of appendiceal diverticulosis.
  • As acquired diverticula represent a rare finding, examination of the entire appendix in this setting does not create a significant impact on the workload within the pathologic laboratory.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Appendix / pathology. Carcinoid Tumor / pathology. Cystadenoma, Mucinous / pathology. Diverticulum / pathology

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  • (PMID = 18715614.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Andreopoulou E, Yee H, Warycha MA, Macari M, Berman R, Lowy A, Muggia F: Mucinous cancer of the appendix: challenges in diagnosis and treatment. J Chemother; 2007 Aug;19(4):451-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucinous cancer of the appendix: challenges in diagnosis and treatment.
  • The authors report and discuss a case of a mucinous carcinoma of the appendix, a rare entity with a distinct natural history that poses diagnostic and therapeutic challenges.
  • Mucinous peritoneal carcinomatosis is most commonly associated with primary tumors of the appendix and colon.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / surgery. Appendiceal Neoplasms / diagnosis. Appendiceal Neoplasms / surgery. Appendix

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  • (PMID = 17855191.001).
  • [ISSN] 1120-009X
  • [Journal-full-title] Journal of chemotherapy (Florence, Italy)
  • [ISO-abbreviation] J Chemother
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / T32CA09454
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen
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15. Gustafsson BI, Siddique L, Chan A, Dong M, Drozdov I, Kidd M, Modlin IM: Uncommon cancers of the small intestine, appendix and colon: an analysis of SEER 1973-2004, and current diagnosis and therapy. Int J Oncol; 2008 Dec;33(6):1121-31
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  • [Title] Uncommon cancers of the small intestine, appendix and colon: an analysis of SEER 1973-2004, and current diagnosis and therapy.
  • Although colon adenocarcinomas constitute approximately 90% of all malignant intestinal neoplasia, the remaining 10% of tumors in the small intestine (SI), appendix and colon are clinically relevant since their late presentation due to a paucity of overt symptoms culminates in a high mortality rate despite the fact that many such lesions are not intrinsically aggressive neoplasia.
  • Thus, neuroendocrine tumors (NETs), adenocarcinomas (except for colonic), lymphomas, sarcomas and GI stromal tumors (GISTs) of the SI, appendix and colon, while relatively rare, represent an under-recognized and underserved group of lesions.
  • [MeSH-major] Appendiceal Neoplasms / epidemiology. Colonic Neoplasms / epidemiology. Intestinal Neoplasms / epidemiology. Intestine, Small / pathology
  • [MeSH-minor] Adenocarcinoma / epidemiology. Gastrointestinal Stromal Tumors / epidemiology. Humans. Lymphoma / epidemiology. Neuroendocrine Tumors / epidemiology. SEER Program. Sarcoma / epidemiology. Survival Analysis. Time Factors. Treatment Outcome. United States / epidemiology

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  • (PMID = 19020744.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Greece
  • [Number-of-references] 68
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16. Maheshwari V, Tsung A, Lin Y, Zeh HJ 3rd, Finkelstein SD, Bartlett DL: Analysis of loss of heterozygosity for tumor-suppressor genes can accurately classify and predict the clinical behavior of mucinous tumors arising from the appendix. Ann Surg Oncol; 2006 Dec;13(12):1610-6
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  • [Title] Analysis of loss of heterozygosity for tumor-suppressor genes can accurately classify and predict the clinical behavior of mucinous tumors arising from the appendix.
  • METHODS: Tissue specimens from 23 mucinous appendiceal tumors were analyzed.
  • [MeSH-major] Adenocarcinoma, Mucinous / genetics. Appendiceal Neoplasms / genetics. Genes, Tumor Suppressor. Loss of Heterozygosity / genetics. Pseudomyxoma Peritonei / genetics

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  • (PMID = 17009159.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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17. Tynan JR, Marshall GB, Gray RR: Answer to case of the month #107. Appendiceal mucocele as a presentation of mucinous adenocarcinoma. Can Assoc Radiol J; 2006 Apr;57(2):117-9
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  • [Title] Answer to case of the month #107. Appendiceal mucocele as a presentation of mucinous adenocarcinoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / complications. Appendiceal Neoplasms / complications. Appendix. Cecal Diseases / etiology. Mucocele / etiology

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  • (PMID = 16944685.001).
  • [ISSN] 0846-5371
  • [Journal-full-title] Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes
  • [ISO-abbreviation] Can Assoc Radiol J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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18. Sayles M, Courtney E, Younis F, O'Donovan M, Ibrahim A, Fearnhead NS: Appendiceal mucinous adenocarcinoma presenting as an enterocutaneous fistula in an incisional hernia. BMJ Case Rep; 2010;2010
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  • [Title] Appendiceal mucinous adenocarcinoma presenting as an enterocutaneous fistula in an incisional hernia.
  • Following incision and drainage of the abscess, CT demonstrated an enterocutaneous fistula between the appendix and bone-graft incision with appendicitis assumed to be the original cause of the abscess.
  • At laparoscopy, the appendix was adherent to the hernia sac with mucinous material at the superficial orifice of the fistula site but not in the peritoneal cavity.
  • Histological evaluation confirmed a well-to-moderately differentiated mucinous adenocarcinoma arising on a background of dysplastic villous adenoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Appendiceal Neoplasms / diagnosis. Bone Transplantation. Hernia, Abdominal / diagnosis. Ilium / surgery. Intestinal Fistula / diagnosis. Postoperative Complications / diagnosis. Tissue and Organ Harvesting
  • [MeSH-minor] Abdominal Abscess / diagnosis. Aged. Appendectomy. Colectomy. Female. Humans. Laparoscopy. Lymph Node Excision. Neoplasm Staging. Reoperation

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  • (PMID = 22789695.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3038038
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19. Matsushita M, Ando Y, Omiya M, Uchida K, Nishio A, Okazaki K: Association of "ulcerative appendicitis" and appendiceal adenocarcinoma. Inflamm Bowel Dis; 2009 Sep;15(9):1283
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  • [Title] Association of "ulcerative appendicitis" and appendiceal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / complications. Appendiceal Neoplasms / complications. Appendicitis / complications. Colitis, Ulcerative / complications
  • [MeSH-minor] Diagnosis, Differential. Humans. Mucocele / etiology

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  • [CommentOn] Inflamm Bowel Dis. 2008 Jun;14(6):873-4 [18275069.001]
  • (PMID = 18951377.001).
  • [ISSN] 1536-4844
  • [Journal-full-title] Inflammatory bowel diseases
  • [ISO-abbreviation] Inflamm. Bowel Dis.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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20. Chetty R, Klimstra DS, Henson DE, Albores-Saavedra J: Combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix. Am J Surg Pathol; 2010 Aug;34(8):1163-7
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  • [Title] Combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix.
  • Carcinoid tumors are the most common neoplasms of the appendix.
  • In this report, we describe 5 cases of combined classical carcinoid and goblet cell carcinoid (GCC) tumors of the appendix.
  • The tumors (0.6 to 6.0 cm) were located in the mid-portion and the tip of the appendix.
  • All 5 appendiceal tumors had microscopic features of both classical carcinoid and GCC, either intimately admixed or separate but closely apposed.
  • The pelvic soft tissue and ovarian metastases in case 4 consisted predominantly of a signet ring cell carcinoma with a minor component of goblet cells and was interpreted as an adenocarcinoma ex-GCC.
  • In view of the fact that these combined carcinoid tumors appear to behave more as goblet cell carcinoids, detailed microscopic examination of classical carcinoid tumors of the appendix is suggested and larger series with longer follow-up is required to ascertain the true biologic potential of this unique form of combined carcinoid tumor of the appendix.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Goblet Cells / pathology. Mixed Tumor, Malignant / pathology

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  • [CommentIn] Am J Surg Pathol. 2011 Aug;35(8):1248-50 [21753706.001]
  • (PMID = 20631606.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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21. Pai RK, Beck AH, Norton JA, Longacre TA: Appendiceal mucinous neoplasms: clinicopathologic study of 116 cases with analysis of factors predicting recurrence. Am J Surg Pathol; 2009 Oct;33(10):1425-39
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  • [Title] Appendiceal mucinous neoplasms: clinicopathologic study of 116 cases with analysis of factors predicting recurrence.
  • The classification and nomenclature of appendiceal mucinous neoplasms are controversial.
  • To determine the outcome for patients with appendiceal mucinous neoplasms and further evaluate whether they can be stratified into groups that provide prognostic information, the clinicopathologic features of 116 patients (66 with clinical follow-up) with appendiceal mucinous neoplasms were studied.
  • From a wide variety of histopathologic features assessed, the important predictors that emerged on univariate statistical analysis were presence of extra-appendiceal neoplastic epithelium (P=0.01), high-grade cytology (P<0.0001), architectural complexity (P<0.001), and invasion (P<0.001).
  • All 16 patients with mucinous neoplasms confined to the appendix and lacking high-grade cytology, architectural complexity, and invasion were alive with no recurrences at median 59 months follow-up (=mucinous adenoma).
  • Twenty-seven patients with low-grade mucinous neoplasms with extra-appendiceal neoplastic epithelium had 1-year, 3-year, 5-year, and 10-year overall survival rates of 96%, 91%, 79%, and 46%, respectively, at median 53 months follow-up (=low-grade mucinous neoplasm with high risk of recurrence).
  • Three of the 4 patients with extra-appendiceal epithelium limited to the right lower quadrant developed full-blown peritoneal disease at 6, 41, and 99 months follow-up and 1 patient eventually died of disease.
  • Nine patients with appendiceal neoplasms with invasion or high-grade cytology and follow-up showed 1-year, 3-year, and 5-year overall survival rates of 86%, 57%, and 28% (=mucinous adenocarcinoma).
  • At 10 years, all patients with mucinous adenocarcinoma were either dead or lost to follow-up.
  • Appendiceal mucinous neoplasms can be stratified into 4 distinct risk groups on the basis of a careful histopathologic assessment of cytoarchitectural features and extent of disease at presentation.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology. Neoplasm Recurrence, Local / epidemiology

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  • (PMID = 19641451.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NLM NIH HHS / LM / T15 LM007033
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Takeda Y, Nakase H, Mikami S, Inoue T, Satou S, Sakai Y, Chiba T: Possible link between ulcerative colitis and in situ adenocarcinoma of an appendiceal mucocele: importance of inflammation in the appendiceal orifice related to UC. Inflamm Bowel Dis; 2008 Jun;14(6):873-4
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  • [Title] Possible link between ulcerative colitis and in situ adenocarcinoma of an appendiceal mucocele: importance of inflammation in the appendiceal orifice related to UC.
  • [MeSH-major] Adenocarcinoma / complications. Appendix. Colitis, Ulcerative / complications. Mucocele / etiology

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  • [CommentIn] Inflamm Bowel Dis. 2009 Sep;15(9):1283 [18951377.001]
  • (PMID = 18275069.001).
  • [ISSN] 1078-0998
  • [Journal-full-title] Inflammatory bowel diseases
  • [ISO-abbreviation] Inflamm. Bowel Dis.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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23. Heinzelmann-Schwarz VA, Scolyer RA, Scurry JP, Smith AN, Gardiner-Garden M, Biankin AV, Baron-Hay S, Scott C, Ward RL, Fink D, Hacker NF, Sutherland RL, O'Brien PM: Low meprin alpha expression differentiates primary ovarian mucinous carcinoma from gastrointestinal cancers that commonly metastasise to the ovaries. J Clin Pathol; 2007 Jun;60(6):622-6
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  • BACKGROUND: Currently, no specific immunohistochemical markers are available to differentiate primary mucinous epithelial ovarian cancer (MOC) from adenocarcinomas originating at other sites that have metastasised to the ovary, which may have an impact on patient management and prognosis.
  • METHODS: Using immunohistochemical analysis, the expression of galectin 4 and meprin alpha was investigated in 10 MOCs and in 38 mucinous adenocarcinomas of colon, pancreas, stomach and appendix, the most common sites of origin of ovarian metastases.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Biomarkers, Tumor / metabolism. Gastrointestinal Neoplasms / pathology. Metalloendopeptidases / metabolism. Ovarian Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / metabolism. Adenocarcinoma / secondary. Diagnosis, Differential. Female. Galectin 4 / metabolism. Humans. Immunoenzyme Techniques. Keratin-20 / metabolism. Keratin-7 / metabolism. Neoplasm Proteins / metabolism

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  • (PMID = 16822880.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Galectin 4; 0 / Keratin-20; 0 / Keratin-7; 0 / Neoplasm Proteins; EC 3.4.24.- / Metalloendopeptidases; EC 3.4.24.18 / meprin A
  • [Other-IDs] NLM/ PMC1955076
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24. Pokala N, Delaney CP, Kiran RP, Brady K, Senagore AJ: Outcome of laparoscopic colectomy for polyps not suitable for endoscopic resection. Surg Endosc; 2007 Mar;21(3):400-3
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  • Mean polyp size was 3.1 cm, and pathology revealed tubular (n = 14), tubulovillous (n = 33) and villous adenoma (n = 2), pseudopolyp (n = 1), and prolapse of the appendix into the cecum mimicking an adenoma (n = 1).
  • Adenocarcinoma not identified at colonoscopy was found in 11 polyps (20%), 9 tubulovillous (27.8%) and both villous adenomas (100%).
  • CONCLUSIONS: Large colonic polyps unresectable at colonoscopy are associated with a high rate of unsuspected cancer.

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  • (PMID = 17180271.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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25. Palanivelu C, Rangarajan M, John SJ, Senthilkumar K, Annapoorni S: Laparoscopic right hemicolectomy for mucocele due to a low-grade appendiceal mucinous neoplasm. JSLS; 2008 Apr-Jun;12(2):194-7
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  • [Title] Laparoscopic right hemicolectomy for mucocele due to a low-grade appendiceal mucinous neoplasm.
  • Tumors of the appendix are rare entities causing mucoceles.
  • Laparoscopic surgery for appendiceal tumors is still controversial, as inadvertent rupture of the lesion due to improper handling will cause pseudomyxoma peritonei.
  • The patient was incidentally discovered to have an appendiceal tumor and referred to us for laparoscopy.
  • Because the tumor involved the entire appendix, a laparoscopic right hemicolectomy was performed without directly handling the tumor.
  • Pathological diagnosis was low-grade appendiceal mucinous neoplasm.
  • The safety of laparoscopic appendectomy for the management of incidentally discovered appendiceal tumors has not yet been established.
  • A formal right hemicolectomy was performed because the tumor involved the entire appendix.
  • We now think laparoscopic surgery for appendiceal tumors is safe, feasible, and even may be beneficial.

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  • (PMID = 18435897.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3016193
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26. Knutsen A, Sielaff TD, Greeno E, Tuttle TM: Staged laparoscopic infusion of hyperthermic intraperitoneal chemotherapy after cytoreductive surgery. J Gastrointest Surg; 2006 Jul-Aug;10(7):1038-43
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  • Primary malignancies included adenocarcinoma of the ileum (one patient), adenocarcinoma of the appendix (three patients), and adenocarcinoma of the gallbladder (one patient).
  • Quality of life was measured with the Functional Assessment of Cancer Therapy-Colon Subscale (FACT-C).
  • [MeSH-major] Adenocarcinoma / drug therapy. Antibiotics, Antineoplastic / administration & dosage. Hyperthermia, Induced / methods. Infusions, Parenteral / methods. Peritoneal Neoplasms / drug therapy

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  • (PMID = 16843875.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 50SG953SK6 / Mitomycin
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27. Zermani R, Chelbi E, Farah F, Rameh S, Kourda N, Ferchichi L, Sayari S, Zaouche A, Ben Jilani S: [Serrated adenoma of the appendix associated with colonic adenocarcinoma]. Tunis Med; 2009 Jan;87(1):97
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  • [Title] [Serrated adenoma of the appendix associated with colonic adenocarcinoma].
  • [Transliterated title] Adénome festonné de l'appendice associé a un adénocarcinome colique.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Appendiceal Neoplasms / pathology. Colonic Neoplasms / pathology

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  • (PMID = 19522437.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Tunisia
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28. Varghese S, Burness M, Xu H, Beresnev T, Pingpank J, Alexander HR: Site-specific gene expression profiles and novel molecular prognostic factors in patients with lower gastrointestinal adenocarcinoma diffusely metastatic to liver or peritoneum. Ann Surg Oncol; 2007 Dec;14(12):3460-71
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  • [Title] Site-specific gene expression profiles and novel molecular prognostic factors in patients with lower gastrointestinal adenocarcinoma diffusely metastatic to liver or peritoneum.
  • BACKGROUND: Generally, colorectal and high-grade appendiceal cancers are treated similarly; treatment approach is primarily based on tumor histology and stage of disease.
  • Patients with adenocarcinoma of the lower gastrointestinal tract frequently experience diffuse metastases isolated to liver or peritoneum and have a poor survival.
  • METHODS: Microarray analyses of 20 metastatic tumors from patients with colorectal adenocarcinoma isolated to liver or peritoneum and eight high-grade appendiceal adenocarcinoma metastatic to peritoneum were performed using oligonucleotide microarray.
  • Subsets of genes significantly associated with poor survival were defined, a RET proto-oncogene interacting gene, GOLGA5, was highly predictive for survival in patients with colorectal adenocarcinoma.
  • CONCLUSIONS: These results demonstrate that liver and peritoneal metastases of lower GI adenocarcinoma have distinct gene expression patterns; these distinctions may help in the development of therapies based on site of metastases.
  • [MeSH-major] Adenocarcinoma / genetics. Biomarkers, Tumor / genetics. Colorectal Neoplasms / genetics. Gene Expression Profiling. Liver Neoplasms / genetics

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  • (PMID = 17899288.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA, Messenger
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29. Levy AD, Shaw JC, Sobin LH: Secondary tumors and tumorlike lesions of the peritoneal cavity: imaging features with pathologic correlation. Radiographics; 2009 Mar-Apr;29(2):347-73
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  • However, when low-grade mucinous adenocarcinoma of the appendix spreads to the peritoneal cavity, the consequence is typically pseudomyxoma peritonei, which is a clinical syndrome, characterized by recurrent and recalcitrant voluminous mucinous ascites due to surface growth on the peritoneum without significant invasion of underlying tissues.
  • [MeSH-major] Neoplasms, Mesothelial / diagnosis. Neoplasms, Mesothelial / secondary. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / secondary. Tomography, X-Ray Computed / methods. Ultrasonography / methods

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  • (PMID = 19325052.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 93
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30. Gungor T, Altinkaya O, Ozat M, Sirvan L, Yalcin H, Mollamahmutoglu L: Primary adenocarcinoid tumor of the ovary arising in mature cystic teratoma. A case report. Eur J Gynaecol Oncol; 2009;30(1):110-2
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  • Examination of the resected lymphatic, omental and appendiceal tissue indicated no tumoral invasion.
  • Thus, the diagnosis was primary ovarian carcinoid arising from a mature cystic teratoma.
  • This case, in the setting of a normal appendix and negative workup for an extraovarian origin, is one of a primary ovarian adenocarcinoid tumor.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoid Tumor / pathology. Neoplasms, Second Primary. Ovarian Neoplasms / pathology. Teratoma / pathology


31. Trivedi AN, Levine EA, Mishra G: Adenocarcinoma of the appendix is rarely detected by colonoscopy. J Gastrointest Surg; 2009 Apr;13(4):668-75
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  • [Title] Adenocarcinoma of the appendix is rarely detected by colonoscopy.
  • INTRODUCTION: Appendiceal tumors represent a subset of colonic neoplasms that frequently defy early diagnosis only to present at advanced stage with peritoneal metastasis.
  • The aim of this study is to determine the diagnostic yield of colonoscopy in detecting appendiceal lesions in patients with appendiceal adenocarcinoma and pseudomyxoma peritonei.
  • METHODS: We reviewed clinicopathologic data on 121 consecutive patients with histologically confirmed appendiceal adenocarcinoma with pseudomyxoma peritonei presenting to our institution for intraperitoneal hyperthermic chemotherapy (IPHC) and cytoreductive surgery between February, 1993 and August, 2007, focusing on the colonoscopy findings.
  • Abnormal findings included seven patients with appendiceal lesions (11%), 12 patients with cecal abnormalities (19%), and 28 patients with polyps (44%).
  • CONCLUSIONS: Appendiceal abnormalities are infrequently seen on colonoscopy and rarely yield a diagnostic biopsy in patients with appendiceal carcinoma.
  • We found that nearly 42% of patients with carcinoma of the appendix have synchronous colonic polyps, a much higher prevalence than would be expected, supporting a role for a perioperative colonoscopy.
  • [MeSH-major] Adenocarcinoma / diagnosis. Appendiceal Neoplasms / diagnosis. Colonoscopy. Peritoneal Neoplasms / diagnosis. Pseudomyxoma Peritonei / diagnosis

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  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
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32. Nair RL, Tobias J, Stemmerman G, Lowy AM: Cerebral edema in a patient following cytoreductive surgery and hyperthermic intraoperative intraperitoneal chemoperfusion. World J Surg Oncol; 2006;4:85
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  • We describe a fatal case of cerebral edema in a patient with appendiceal carcinoma and an underlying seizure disorder who underwent cytoreductive surgery and HIPEC.
  • CASE PRESENTATION: A case of fatal postoperative cerebral edema is presented in a patient with an underlying seizure disorder and recurrent mucinous adenocarcinoma of the appendix.

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  • (PMID = 17137499.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1697813
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33. Bucher P, Gervaz P, Ris F, Oulhaci W, Egger JF, Morel P: Surgical treatment of appendiceal adenocarcinoid (goblet cell carcinoid). World J Surg; 2005 Nov;29(11):1436-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment of appendiceal adenocarcinoid (goblet cell carcinoid).
  • Adenocarcinoid of the appendix is an infrequent tumor with histologic features of both adenocarcinoma and carcinoid tumor.
  • The aim of this study was to analyze long-term results of surgical treatment for appendiceal adenocarcinoid.
  • A retrospective review (1991-2003) identified seven patients (median age 72, range 27-81 years) treated for appendiceal adenocarcinoid.
  • Our results suggest that appendectomy alone could be used for appendiceal adenocarcinoid provided that the tumor (1) is less than 1 cm;.
  • (2) does not extend beyond the appendix adventitia;.
  • The risk for developing colorectal adenocarcinoma seems to be extremely high in patients treated for appendiceal adenocarcinoid and warrants close follow-up with colonoscopic screening.
  • [MeSH-major] Appendectomy. Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery

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34. Velusamy A, Saw S, Gossage J, Bailey S, Schofield J: Combined adenocarcinoid and mucinous cystadenoma of the appendix: a case report. J Med Case Rep; 2009;3:28
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combined adenocarcinoid and mucinous cystadenoma of the appendix: a case report.
  • INTRODUCTION: Adenocarcinoid of the appendix is a rare malignant tumour with features of both adenocarcinoma and carcinoid, showing both epithelial and endocrine differentiation.
  • Mucinous cystadenoma is the commonest of the benign neoplasms of the appendix, with an incidence of 0.6% in appendicectomy specimens.
  • Laparoscopy revealed an adenocarcinoid of the appendix in combination with mucinous cystadenoma.
  • CONCLUSION: Adenocarcinoids account for 2% of primary appendiceal malignancies.

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  • (PMID = 19171048.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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35. Fu K, Horimatsu T, Sano Y, Katagiri A, Kaji Y, Fujimori T: Metastasis to the appendix from gastric cancer detected incidentally on colonoscopy. Endoscopy; 2007 Feb;39 Suppl 1:E17
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastasis to the appendix from gastric cancer detected incidentally on colonoscopy.
  • [MeSH-major] Adenocarcinoma / secondary. Appendiceal Neoplasms / secondary. Colonoscopy. Incidental Findings. Stomach Neoplasms / diagnosis

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  • (PMID = 17285508.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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36. Leanza S, Bekheit M, Coco D, Bellia A, Ferrara F, Sarvà S, Pappalardo A, Piazza L: Carcinoma of the appendix and its natural history in relation to surgical management. A case report. Chir Ital; 2009 Sep-Dec;61(5-6):597-600
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoma of the appendix and its natural history in relation to surgical management. A case report.
  • There are several classifications of appendicular epithelial cancer with a wide variety of nomenclature.
  • Epithelial tumours of the appendix have been classified into four distinct types: carcinoids, mucinous adenocarcinoma (often called mucinous cystadenocarcinoma or malignant mucocele), colonic-type adenocarcinoma, and adenocarcinoids with a dual cell origin.
  • The histopathological analysis showed the presence of a well differentiated mucinous adenocarcinoma, infiltrating the full thickness of the appendix wall.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / surgery. Appendiceal Neoplasms / diagnosis. Appendiceal Neoplasms / surgery

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  • (PMID = 20380264.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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37. Vang R, Gown AM, Barry TS, Wheeler DT, Ronnett BM: Immunohistochemistry for estrogen and progesterone receptors in the distinction of primary and metastatic mucinous tumors in the ovary: an analysis of 124 cases. Mod Pathol; 2006 Jan;19(1):97-105
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Immunohistochemical studies were performed on 124 mucinous tumors, including 52 primary ovarian tumors (30 atypical proliferative (borderline) mucinous tumors of gastrointestinal type, 11 atypical proliferative (borderline) mucinous tumors of seromucinous (endocervical-like) type, and 11 invasive mucinous carcinomas of usual (gastrointestinal) type) and 72 metastatic mucinous carcinomas in the ovary (primary sites: colorectum (24), pancreas (13), endocervix (eight), stomach (four), gallbladder/bile duct (four), appendix (four), and unknown (15)).
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Ovarian Neoplasms / secondary. Receptors, Estrogen / analysis. Receptors, Progesterone / analysis
  • [MeSH-minor] Appendiceal Neoplasms / metabolism. Appendiceal Neoplasms / pathology. Colorectal Neoplasms / metabolism. Colorectal Neoplasms / pathology. Diagnosis, Differential. Female. Gallbladder Neoplasms / metabolism. Gallbladder Neoplasms / pathology. Humans. Immunohistochemistry. Neoplasms, Unknown Primary / metabolism. Neoplasms, Unknown Primary / pathology. Ovary / chemistry. Ovary / pathology. Pancreatic Neoplasms / metabolism. Pancreatic Neoplasms / pathology. Stomach Neoplasms / metabolism. Stomach Neoplasms / pathology. Uterine Cervical Neoplasms / metabolism. Uterine Cervical Neoplasms / pathology

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  • (PMID = 16294196.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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38. Stojanović I, Karamehmedović Z, Elgazwi K, Baća I: Laparoscopic treatment of cystadenocarcinoma of the appendix penetrating in the sigmoid colon. JSLS; 2009 Jul-Sep;13(3):445-9
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  • [Title] Laparoscopic treatment of cystadenocarcinoma of the appendix penetrating in the sigmoid colon.
  • Adenocarcinoma of the vermiform appendix is a rare neoplasm of the gastrointestinal tract that most commonly presents as right lower abdominal pain, mimicking acute appendicitis.
  • An accurate and complete preoperative diagnosis has been rare in the past; however, modern imaging techniques allow recognition of most complications and associated conditions.
  • The diagnosis is confirmed postoperatively.
  • Aggressive surgical management is the treatment of choice in appendicular adenocarcinoma.

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  • [Cites] Int J Urol. 2001 Apr;8(4):196-8 [11260355.001]
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  • (PMID = 19793493.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  • [Other-IDs] NLM/ PMC3015953
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39. Rohani P, Scotti SD, Shen P, Stewart JH, Russell GB, Cromer M, Levine EA: Use of FDG-PET imaging for patients with disseminated cancer of the appendix. Am Surg; 2010 Dec;76(12):1338-44
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  • [Title] Use of FDG-PET imaging for patients with disseminated cancer of the appendix.
  • The goal of this study is to evaluate the use of positron emission tomography (PET) in evaluation of patients with peritoneal dissemination of carcinoma of appendiceal origin (PDA).
  • We do not recommend the use of FDG-PET for patients with PDA from cancer of the appendix.
  • [MeSH-major] Adenocarcinoma, Mucinous / radionuclide imaging. Appendiceal Neoplasms / pathology. Peritoneal Neoplasms / radionuclide imaging. Positron-Emission Tomography. Pseudomyxoma Peritonei / radionuclide imaging

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  • (PMID = 21265346.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / K08 CA131482
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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40. Paklina OV, Setdikova GR, Nikitin PN, Petropavlovskiĭ AI: [Goblet-cell carcinoid of the colon]. Arkh Patol; 2008 Mar-Apr;70(2):45-7
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  • The authors describe a case of goblet-cell carcinoid of the appendix subject to additional immunohistological study.
  • Goblet-cell carcinoid is a rare colonic tumor comprises the morphological signs of adenocarcinoma and carcinoid.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoid Tumor / pathology. Colonic Neoplasms / pathology

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  • (PMID = 18540443.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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41. Lochman P, Cáp R, Kohout A: Adenocarcinoma of the appendix and a Meckel's diverticulum in a case of acute appendicitis. Onkologie; 2007 Sep;30(8-9):457-8
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  • [Title] Adenocarcinoma of the appendix and a Meckel's diverticulum in a case of acute appendicitis.
  • [MeSH-major] Adenocarcinoma / complications. Adenocarcinoma / diagnosis. Appendiceal Neoplasms / complications. Appendiceal Neoplasms / diagnosis. Appendicitis / complications. Appendicitis / diagnosis. Meckel Diverticulum / complications. Meckel Diverticulum / diagnosis

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  • (PMID = 17848820.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Switzerland
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42. Wang GL, Wang MY, Wei WB: [Clinical features and treatment of choroidal metastasis]. Zhonghua Yan Ke Za Zhi; 2009 Mar;45(3):229-33
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  • Primary tumours were found in 40 cases (81.6%) (surgical excision in 25 cases), consisting of breast carcinoma in 16 cases (32.7%), lung carcinoma in 14 cases (28.6%), hepatoma and cholangiocarcinoma in 3 cases, colon and stomach carcinomas in 3 cases, gynecologic appendix carcinoma (including 1 case of ovarian mucous cyst adenocarcinoma) in 2 cases, nasopharyngeal adenocarcinoma in 1 case, vertebra tumor in 1 case, undetected in 5 cases (10.2%) and under detection in 4 cases (8.2%).
  • The most common primary cancer is breast carcinoma, followed by lung carcinoma.

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  • (PMID = 19575917.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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43. Mizuta Y, Akazawa Y, Shiozawa K, Ohara H, Ohba K, Ohnita K, Isomoto H, Takeshima F, Omagari K, Tanaka K, Yasutake T, Nakagoe T, Shirono K, Kohno S: Pseudomyxoma peritonei accompanied by intraductal papillary mucinous neoplasm of the pancreas. Pancreatology; 2005;5(4-5):470-4
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  • No primary tumour, including mucinous neoplasm of the appendix, was found.
  • Histopathological examination of the omentum showed mucinous adenocarcinoma in pools of mucoid material, consistent with PMP.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Papillary / pathology. Carcinoma, Pancreatic Ductal / pathology. Pancreatic Neoplasms / pathology. Peritoneal Neoplasms / pathology. Pseudomyxoma Peritonei / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Ascites / pathology. Chemotherapy, Cancer, Regional Perfusion. Cisplatin / administration & dosage. Deoxycytidine / analogs & derivatives. Etoposide / administration & dosage. Humans. Hyperthermia, Induced. Infusions, Parenteral. Male. Middle Aged. Mitomycin / administration & dosage. Neoplasms, Multiple Primary

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  • [Copyright] Copyright 2005 S. Karger AG, Basel and IAP.
  • (PMID = 15983445.001).
  • [ISSN] 1424-3903
  • [Journal-full-title] Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
  • [ISO-abbreviation] Pancreatology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; 50SG953SK6 / Mitomycin; 6PLQ3CP4P3 / Etoposide; B76N6SBZ8R / gemcitabine; Q20Q21Q62J / Cisplatin
  • [Number-of-references] 19
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44. Kunz J, Makek M: [Primary adenocarcinoma of the appendix as differential diagnosis of advanced ovarian carcinoma]. Praxis (Bern 1994); 2006 Aug 16;95(33):1217-25
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  • [Title] [Primary adenocarcinoma of the appendix as differential diagnosis of advanced ovarian carcinoma].
  • [Transliterated title] Das primäre Adenokarzinom der Appendix als Differentialdiagnose des fortgeschrittenen Ovarialkarzinoms.
  • Malignant tumours of the appendix are rare.
  • Metastatic mucinous adenocarcinomas of the appendix are only reported as case histories.
  • Advanced primary adenocarcinomas of the appendix with ovarian metastases cannot be distinguished intraoperatively from a FIGO III ovarian carcinoma.
  • The pathologist makes the definitive diagnosis.
  • Surgical therapy of the isolated primary appendiceal carcinoma consists of a hemicolectomy--an appendectomy in favourable cases--and, in the case of a metastasised carcinoma, according to the guidelines for an advanced ovarian or colon carcinoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / secondary. Appendiceal Neoplasms / diagnosis. Carcinoma, Signet Ring Cell / diagnosis. Carcinoma, Signet Ring Cell / secondary. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / secondary
  • [MeSH-minor] Appendix / pathology. Appendix / surgery. Diagnosis, Differential. Female. Humans. Hysterectomy, Vaginal. Middle Aged. Omentum / pathology. Omentum / surgery. Ovary / pathology. Ovary / surgery. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / pathology. Peritoneal Neoplasms / secondary. Peritoneal Neoplasms / surgery. Peritoneum / pathology. Peritoneum / surgery. Postoperative Complications / diagnosis. Postoperative Complications / pathology. Postoperative Complications / surgery. Reoperation

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  • (PMID = 16939122.001).
  • [ISSN] 1661-8157
  • [Journal-full-title] Praxis
  • [ISO-abbreviation] Praxis (Bern 1994)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Switzerland
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45. Ahmed K, Hoque R, El-Tawil S, Khan MS, George ML: Adenocarcinoma of the appendix presenting as bilateral ureteric obstruction. World J Surg Oncol; 2008;6:23
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  • [Title] Adenocarcinoma of the appendix presenting as bilateral ureteric obstruction.
  • BACKGROUND: Adenocarcinoma of the vermiform appendix is a rare neoplasm of the gastrointestinal tract.
  • These presentations reflect various stages of a locally expanding tumour causing luminal obstruction of appendix.
  • CASE PRESENTATION: We report a case of appendicular adenocarcinoma found unexpectedly in a 43 year old male who presented with urinary symptoms.
  • Histopathology revealed well differentiated adenocarcinoma with signet ring morphology with multiple lymph node involvement.
  • Every attempt should be made to make a precise diagnosis through all the available means to direct the treatment along correct lines.
  • [MeSH-major] Adenocarcinoma / complications. Adenocarcinoma / diagnosis. Appendiceal Neoplasms / complications. Appendiceal Neoplasms / diagnosis. Ureteral Obstruction / etiology

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  • (PMID = 18291037.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2277416
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46. Zedníková I, Kuntscher V, Schmiedhuber P, Daum O: [Mucinous adenocarcinoma of the appendix--case report]. Rozhl Chir; 2010 Nov;89(11):682-4
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  • [Title] [Mucinous adenocarcinoma of the appendix--case report].
  • [Transliterated title] Mucinózni adenokarcinom apendixu--kazuistika.
  • The authors are describing a case of a patient with the diagnosis of the appendicular cancer.
  • The 66-year-old patient underwent appendectomy because of signs of acute appendicitis, and than in the next step right-sided hemicolectomy because of histological finding of the mucinous adenocarcinoma of the appendix.
  • Mucinous adenocarcinoma is the most common type of appendicular cancer, none the less this diagnosis is very rare.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Appendiceal Neoplasms / diagnosis

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  • (PMID = 21409802.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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47. National Toxicology Program: Multigenerational reproductive study of genistein (Cas No. 446-72-0) in Sprague-Dawley rats (feed study). Natl Toxicol Program Tech Rep Ser; 2008 Mar;(539):1-266
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  • These results have been reported elsewhere (Appendix P) and are not presented in detail in this report.
  • [MeSH-minor] Adenocarcinoma / chemically induced. Adenocarcinoma / pathology. Adenoma / chemically induced. Adenoma / pathology. Animals. Female. Male. Mammary Neoplasms, Animal / chemically induced. Mammary Neoplasms, Animal / pathology. Pituitary Neoplasms / chemically induced. Pituitary Neoplasms / pathology. Pregnancy. Rats. Rats, Sprague-Dawley. Recovery of Function. Withholding Treatment

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  • (PMID = 18685713.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Phytoestrogens; DH2M523P0H / Genistein
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48. Okada N, Ishibashi K, Nakada H, Miyazaki T, Sobajima J, Gonda T, Ishida H: [Five cases of pseudomyxoma peritonei underwent abdominal lavage and administering CDDP]. Gan To Kagaku Ryoho; 2007 Nov;34(12):1955-7
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  • These primary lesions contained one case of pancreas and four cases of appendix.
  • Histological types contained one case of well differentiated adenocarcinoma and four cases of signet ring cell carcinoma.

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  • (PMID = 18219863.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin
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49. Goere D: [Guest comment on the article: appendiceal mucoceles, pseudomyxoma peritonei, and appendiceal mucinous neoplasms. Update on the contribution of imaging to choice of the surgical approach, J.F. Gillion et al]. J Chir (Paris); 2009 Apr;146(2):167
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  • [Title] [Guest comment on the article: appendiceal mucoceles, pseudomyxoma peritonei, and appendiceal mucinous neoplasms. Update on the contribution of imaging to choice of the surgical approach, J.F. Gillion et al].
  • [Transliterated title] Commentaire invité de l'article "Mucocèles appendiculaires, pseudomyxomes péritonéaux et tumeurs mucosécrétantes du carrefour iléocaecal: apport de l'imagerie dans la stratégie thérapeutique et le choix de la voie d'abord laparoscopique ou classique" par J.-F. Gillion et al.
  • [MeSH-major] Adenocarcinoma, Mucinous / radiography. Appendiceal Neoplasms / radiography. Appendix / radiography. Mucocele / radiography. Peritoneal Neoplasms / radiography. Pseudomyxoma Peritonei / radiography

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  • [CommentOn] J Chir (Paris). 2009 Apr;146(2):150-66 [19552906.001]
  • (PMID = 19540495.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] Comment; Journal Article
  • [Publication-country] France
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50. Lansdale N, Dagash H, Cohen M, Walker J: An ovarian tumour with a potential appendiceal origin. Pediatr Surg Int; 2008 Feb;24(2):245-7
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  • [Title] An ovarian tumour with a potential appendiceal origin.
  • The appendix was histologically normal.
  • It is known to occur simultaneously with tumours of the appendix.
  • Paediatric surgeons need to be aware of this rare tumour and when operating on any ovarian pathology should always inspect the peritoneal cavity for mucinous deposits and examine the appendix.
  • [MeSH-major] Adenocarcinoma, Mucinous / surgery. Appendiceal Neoplasms / surgery. Ovarian Neoplasms / surgery
  • [MeSH-minor] Adolescent. Appendectomy. Diagnosis, Differential. Female. Humans. Laparoscopy

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  • (PMID = 17401568.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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51. Glehen O, Gilly FN, Boutitie F, Bereder JM, Quenet F, Sideris L, Mansvelt B, Lorimier G, Msika S, Elias D, French Surgical Association: Toward curative treatment of peritoneal carcinomatosis from nonovarian origin by cytoreductive surgery combined with perioperative intraperitoneal chemotherapy: a multi-institutional study of 1,290 patients. Cancer; 2010 Dec 15;116(24):5608-18
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  • The principal origins of PC were colorectal adenocarcinoma (N = 523), pseudomyxoma peritonei (N = 301), gastric adenocarcinoma (N = 159), peritoneal mesothelioma (N = 88), and appendiceal adenocarcinoma (N = 50).
  • The overall median survival was 34 months; and the median survival was 30 months for patients with colorectal PC, not reached for patients with pseudomyxoma peritonei, 9 months for patients with gastric PC, 41 months for patients with peritoneal mesothelioma, and 77 months for patients with PC from appendiceal adenocarcinoma.

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  • [Copyright] Copyright © 2010 American Cancer Society.
  • (PMID = 20737573.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Investigator] Karine A; Olivier T; Catherine A; Patrick R; Philippe G; Gwenael F; Pierre M; Cecile B; Frederic M; Jacques TJ; Marc P; Rasmy L; Vincent T; Emily L; Sylvaine D; Kurt Vd
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52. Feo CF, Porcu A, Scanu AM, Ginesu GC, Fancellu A, Lorettu A, Dettori G: Primary appendiceal tumors: report on 10 cases. Int Surg; 2009 Jul-Sep;94(3):224-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary appendiceal tumors: report on 10 cases.
  • We report our experience on 10 patients with primary tumors of the appendix treated at our institution from 1998 to 2005.
  • Two of the four patients with benign tumors died from causes unrelated to the appendiceal neoplasm.
  • Despite the rarity of appendiceal primary tumors, surgeons should be aware of these neoplasms for making correct treatment decisions.
  • We stress the importance of laparoscopic exploration in the management of appendiceal masses.
  • [MeSH-major] Adenocarcinoma / surgery. Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery

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  • (PMID = 20187516.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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53. Lakatos PL, Gyori G, Halasz J, Fuszek P, Papp J, Jaray B, Lukovich P, Lakatos L: Mucocele of the appendix: an unusual cause of lower abdominal pain in a patient with ulcerative colitis. A case report and review of literature. World J Gastroenterol; 2005 Jan 21;11(3):457-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucocele of the appendix: an unusual cause of lower abdominal pain in a patient with ulcerative colitis. A case report and review of literature.
  • Colononoscopy and biopsy established the diagnosis of ulcerative colitis (proctosigmoiditis).
  • Cytology confirmed the diagnosis of mucocele.
  • He recovered well and the final histology revealed a cystadenoma of the appendix.
  • Although primary adenocarcinoma of the appendix is uncommon, the authors emphasize that preoperative diagnosis of an underlying malignancy in a mucocele is important for patient management; however, it is difficult on imaging studies.
  • [MeSH-major] Abdominal Pain / etiology. Appendiceal Neoplasms / complications. Appendix. Cecal Diseases / complications. Colitis, Ulcerative / complications. Cystadenoma / complications. Mucocele / complications
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Ultrasonography

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  • (PMID = 15637769.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 18
  • [Other-IDs] NLM/ PMC4205363
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54. Hirsch I, Kasper HU, Brabender J, Hölscher AH, Dienes HP: [Adenocarcinoid of the appendix vermiformis]. Pathologe; 2005 May;26(3):231-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenocarcinoid of the appendix vermiformis].
  • [Transliterated title] Adenokarzinoid der Appendix vermiformis.
  • Adenocarcinoids are rare tumors with histological features of both carcinoid tumor and adenocarcinoma.
  • It is thought that appendectomy is sufficient in case of small tumors in the tip of the appendix.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology

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  • [Cites] Cancer. 2002 Jun 15;94(12):3307-12 [12115365.001]
  • [Cites] Cancer. 1978 Dec;42(6):2781-93 [728874.001]
  • [Cites] Gut. 1990 Mar;31(3):322-4 [2323597.001]
  • [Cites] Am J Surg. 1994 Dec;168(6):685-7 [7978019.001]
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  • (PMID = 15378268.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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56. Osborne CL, Boulind CE, Cooper E, Francis NK: Incidental cystadenocarcinoma of the appendix in a patient undergoing laparoscopic right hemicolectomy for caecal cancer: a case report. Cases J; 2009;2:7505
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  • [Title] Incidental cystadenocarcinoma of the appendix in a patient undergoing laparoscopic right hemicolectomy for caecal cancer: a case report.
  • Primary appendiceal neoplasms are rare and usually found incidentally after appendicectomy for suspected appendicitis.
  • We report a case of a perforated cystadenocarcinoma of the appendix occurring synchronously with caecal adenocarcinoma in an 81-year-old woman without abdominal symptoms or signs, who presented with iron deficiency anaemia.

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  • (PMID = 19829982.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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57. Wakahara T, Yamamoto S, Fujita S, Akasu T, Onouchi S, Moriya Y: A case of advanced rectal adenocarcinoid tumor with long-term survival. Jpn J Clin Oncol; 2010 Jul;40(7):690-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Adenocarcinoid tumor most commonly occurs in the appendix and a tumor arising in the rectum is extremely rare.
  • [MeSH-major] Adenocarcinoma / diagnosis. Rectal Neoplasms / diagnosis

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  • (PMID = 20338947.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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58. Manigrasso A, Candioli S, Pironi D, La Torre V, Panarese A, Romani AM, Arcieri S, Tarroni D, Palazzini G, Filippini A: [Adenocarcinoma of the appendix. A case report and review of the literature]. G Chir; 2007 Mar;28(3):73-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenocarcinoma of the appendix. A case report and review of the literature].
  • [Transliterated title] L'adenocarcinoma dell'appendice ileo-ciecale: presentazione di un caso clinico e revisione della letteratura.
  • Primary adenocarcinoma of the appendix is a rare malignancy that constitutes less than 0.5% of all gastrointestinal neoplasms.
  • Usually the diagnosis is made only after histological examination of surgically removed inflamed appendix.
  • Alternatively represent an unexpected finding, confirmed by frozen section, during surgery performed for acute appendicitis or other non appendiceal pathologies.
  • Natural history is strongly influenced by anatomic peculiarities of the appendix that predispose to early spread and perforation.
  • The correct management is the right hemicolectomy as a primary procedure in the case of preoperatively or intraoperatively diagnosis or as secondary procedure, after two-three weeks from appendectomy, when the microscopic examination of specimen reveals the presence of adenocarcinoma.
  • The Authors report a case of primary adenocarcinoma of the appendix occurred in a 78 year-old female patient, diagnosed incidentally during surgery performed for ileus from suspected cecal neoplasm.
  • [MeSH-major] Appendiceal Neoplasms. Carcinoma, Signet Ring Cell

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  • (PMID = 17419903.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 36
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59. Innis M, Sandiford N, Shenoy RK, Prussia PR, Zbar A: Carcinoma of the jejunum with multideposit peritoneal seeding, resection and intraperitoneal chemotherapy. West Indian Med J; 2005 Sep;54(4):242-6
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  • Jejunal adenocarcinoma is rare, often presenting late with widespread intraperitoneal disease.
  • Intraperitoneal chemotherapy (IPC) has been shown in non-randomized studies to improve the survival of patients presenting with intraperitoneal metastases from carcinoma of the colon, appendix and stomach and in primary peritoneal malignancies including mesothelioma and pseudomyxoma peritonei, providing that adequate operative cytoreduction can be performed.
  • A case is presented of obstructive jejunal adenocarcinoma in which 19 intraperitoneal deposits were excised.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / surgery. Antineoplastic Combined Chemotherapy Protocols. Jejunal Neoplasms / drug therapy. Jejunal Neoplasms / surgery. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / surgery

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  • (PMID = 16312191.001).
  • [ISSN] 0043-3144
  • [Journal-full-title] The West Indian medical journal
  • [ISO-abbreviation] West Indian Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Jamaica
  • [Chemical-registry-number] Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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60. Graham RP, Williams NP, West KA: Primary epithelial tumours of the appendix in a black population: a review of cases. World J Gastroenterol; 2009 Mar 28;15(12):1472-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary epithelial tumours of the appendix in a black population: a review of cases.
  • AIM: To determine the prevalence, histologic types and clinical features of primary epithelial tumours of the vermiform appendix in a predominantly black population.
  • METHODS: All cases of primary tumours of the appendix identified by review of the histopathology records at the University of the West Indies between January 1987 and June 2007 were selected.
  • A clinical diagnosis of acute appendicitis was the most common reason for appendectomy (57.1%) and was histologically confirmed in 75% (18 of 24) of cases.
  • CONCLUSION: Appendiceal epithelial tumours are rare in our experience, and are represented principally by carcinoid tumours and adenomas.
  • [MeSH-major] African Continental Ancestry Group / statistics & numerical data. Appendiceal Neoplasms / epidemiology. Appendiceal Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Adenoma / epidemiology. Adenoma / pathology. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoid Tumor / epidemiology. Carcinoid Tumor / pathology. Female. Humans. Male. Middle Aged. Prevalence. Retrospective Studies. West Indies / epidemiology. Young Adult

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  • [Cites] Cancer. 2003 Feb 15;97(4):934-59 [12569593.001]
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  • (PMID = 19322920.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2665141
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61. Agaimy A, Pelz AF, Wieacker P, Roessner A, Wünsch PH, Schneider-Stock R: Gastrointestinal stromal tumors of the vermiform appendix: clinicopathologic, immunohistochemical, and molecular study of 2 cases with literature review. Hum Pathol; 2008 Aug;39(8):1252-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gastrointestinal stromal tumors of the vermiform appendix: clinicopathologic, immunohistochemical, and molecular study of 2 cases with literature review.
  • Gastrointestinal stromal tumors (GIST) are rare in the vermiform appendix.
  • Here, we report 2 appendiceal gastrointestinal stromal tumors in a 78-year-old woman and a 72-year-old man with a history of endometrial adenocarcinoma and urinary bladder carcinoma, respectively.
  • We suggest that the molecular pathogenesis of appendiceal gastrointestinal stromal tumors beyond initiating KIT mutations might be different from their gastric and intestinal counterparts.
  • The coincidence of loss of p16 and overexpression of human telomerase reverse transcriptase seems to be in contradiction to the small size, the benign nature, and the limited growth potential of appendiceal gastrointestinal stromal tumors.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Gastrointestinal Stromal Tumors / pathology

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  • (PMID = 18547614.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  • [Number-of-references] 21
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62. Abdu B, Hobgood D, Stallings S, Depasquale S: Incidental finding of pseudomyxoma peritonei at primary cesarean section. Am J Perinatol; 2009 Oct;26(9):633-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Primary appendiceal carcinoma is extremely rare and is found in approximately 1% of appendectomy specimens.
  • When cancer is present, the most frequent histology is mucinous adenocarcinoma.
  • Neoplasms of the appendix that secrete mucin such as adenocarcinoma may rupture, leading to intraperitoneal seeding of the peritoneum and producing the clinical picture of pseudomyxoma peritonei (PMP).
  • A general surgeon was consulted, and grossly necrotic-appearing appendix was noted.
  • Pathology showed well-differentiated mucinous adenocarcinoma of the appendix.
  • Early diagnosis of a potentially life-threatening disease requires that clinicians expand the differential diagnosis and consider the possibility of a malignant neoplasm presenting in the pregnant female.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Cesarean Section. Incidental Findings. Pseudomyxoma Peritonei / pathology

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  • [Copyright] Thieme Medical Publishers.
  • (PMID = 19399708.001).
  • [ISSN] 1098-8785
  • [Journal-full-title] American journal of perinatology
  • [ISO-abbreviation] Am J Perinatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 14
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63. Smeenk RM, van Velthuysen ML, Verwaal VJ, Zoetmulder FA: Appendiceal neoplasms and pseudomyxoma peritonei: a population based study. Eur J Surg Oncol; 2008 Feb;34(2):196-201
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appendiceal neoplasms and pseudomyxoma peritonei: a population based study.
  • BACKGROUND: Pseudomyxoma peritonei (PMP) is a rare disease with an estimated incidence of 1 per million per year, and is thought to originate usually from an appendiceal mucinous epithelial neoplasm.
  • METHODS: The nationwide pathology database of the Netherlands (PALGA) was searched for the incidence of all appendectomies, the incidence of primary epithelial appendiceal lesions and the incidence and pathology history of patients with PMP.
  • An appendiceal lesion was found in 1482 appendiceal specimens (0.9%).
  • Coincidentally, an additional epithelial colonic neoplasm was found in 13% of patients with an appendiceal epithelial lesion.
  • A mucinous epithelial neoplasm was identified in 0.3% (73% benign, 27% malignant) of appendiceal specimens and 20% of these patients developed PMP.
  • The primary site was identified in 68% and dominated by the appendix (82%).
  • CONCLUSIONS: Primary epithelial lesions of the appendix are rare.
  • [MeSH-major] Adenocarcinoma, Mucinous / epidemiology. Appendiceal Neoplasms / epidemiology. Neoplasms, Multiple Primary / epidemiology. Peritoneal Neoplasms / epidemiology. Pseudomyxoma Peritonei / epidemiology

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  • (PMID = 17524597.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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64. Saad-Hossne R, Prado RG, Bakonyi Neto A, Marchezan MA: Peritoneal pseudomyxoma associated with synchronic malignant mucinous neoplasias of the cecum, appendix and rectum. Case report and review of the literature. Acta Cir Bras; 2007 Sep-Oct;22(5):407-11
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  • [Title] Peritoneal pseudomyxoma associated with synchronic malignant mucinous neoplasias of the cecum, appendix and rectum. Case report and review of the literature.
  • We report a peritoneal pseudomyxoma associated with mucinous adenocarcinoma of the appendix synchronic with adenocarcinoma of the rectum in a 44 year old patient, where the initial diagnosis was rectal adenocarcinoma.
  • Tumour of the appendix and peritoneal pseudomyxoma were incidental and found intraoperatively.
  • We focus the histological patterns of the lesions, diagnosis and the treatment, with revision of the literature.

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  • (PMID = 17923963.001).
  • [ISSN] 0102-8650
  • [Journal-full-title] Acta cirurgica brasileira
  • [ISO-abbreviation] Acta Cir Bras
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Brazil
  • [Number-of-references] 33
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65. Daniels JA, Lederman HM, Maitra A, Montgomery EA: Gastrointestinal tract pathology in patients with common variable immunodeficiency (CVID): a clinicopathologic study and review. Am J Surg Pathol; 2007 Dec;31(12):1800-12
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  • Age at diagnosis ranged from 6 months to 62 years (median, 35.5 y), and age at biopsy ranged from 10 months to 67 years (median, 38 y).
  • Gastric adenocarcinoma was identified in one patient.
  • The appendix from 1 patient showed Cryptosporidium and acute serositis with a paucity of plasma cells and an increase in apoptosis.
  • In fact, in our series, we found patients with a prior diagnosis of celiac disease (25%) and inflammatory bowel disease (35%), including Crohn disease (15%).
  • The diagnosis of CVID may be suspected on the basis of the lack of plasma cells in a GI biopsy, but because this feature is only present in about two-thirds of patients, the diagnosis cannot always be suggested in isolation of other clinical and laboratory findings.
  • [MeSH-minor] Adolescent. Adult. Aged. Celiac Disease / pathology. Child. Child, Preschool. Colitis, Collagenous / pathology. Colitis, Lymphocytic / pathology. Diagnosis, Differential. Female. Granulomatous Disease, Chronic / pathology. Humans. Infant. Inflammatory Bowel Diseases / pathology. Male. Middle Aged

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  • (PMID = 18043034.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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66. Sideris L, Mitchell A, Drolet P, Leblanc G, Leclerc YE, Dubé P: Surgical cytoreduction and intraperitoneal chemotherapy for peritoneal carcinomatosis arising from the appendix. Can J Surg; 2009 Apr;52(2):135-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical cytoreduction and intraperitoneal chemotherapy for peritoneal carcinomatosis arising from the appendix.
  • BACKGROUND: Peritoneal carcinomatosis (PC) originating in the appendix is a rare disease for which the long-term prognosis is poor.
  • [MeSH-major] Adenocarcinoma, Mucinous / therapy. Antineoplastic Agents / administration & dosage. Appendiceal Neoplasms / pathology. Hyperthermia, Induced. Peritoneal Neoplasms / therapy

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  • (PMID = 19399209.001).
  • [ISSN] 1488-2310
  • [Journal-full-title] Canadian journal of surgery. Journal canadien de chirurgie
  • [ISO-abbreviation] Can J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 50SG953SK6 / Mitomycin; 7673326042 / irinotecan; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin
  • [Other-IDs] NLM/ PMC2663512
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67. Katsuno G, Kagawa S, Kokudo Y, Muraoka A, Tatemoto A, Sone Y, Tsumura M, Tsuruno M, Mizobuchi K: Ureteral metastasis from appendiceal cancer: report of a case. Surg Today; 2005;35(2):168-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ureteral metastasis from appendiceal cancer: report of a case.
  • We report a case of primary appendiceal cancer that metastasized to the ureter.
  • After a detailed examination she was diagnosed to have cancer of the appendix, multiple liver metastases, and left hydronephrosis.
  • Since an obstruction of the ileocecum was obvious, she underwent an ileocecal resection and a resection of the spindle-shaped tumor invading the left ureter.
  • The spindle-shaped tumor was considered to be due to invasion of the appendiceal cancer to the left ureter.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Ureteral Neoplasms / secondary

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  • (PMID = 15674503.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 15
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68. Nishio R, Furuya Y, Akashi T, Okumura A, Fuse H: Primary adenocarcinoma of the appendix invading the urinary bladder. Int Urol Nephrol; 2006;38(3-4):481-2
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  • [Title] Primary adenocarcinoma of the appendix invading the urinary bladder.
  • We report a case of adenocarcinoma of the appendix invading the urinary bladder in a 75-year-old man.
  • At operation a primary neoplasm of the appendix invading the bladder was discovered and en bloc resection of the urinary bladder with the adherent cecum followed by an ileocolonic anastomosis and ureterocutaneostomy was performed.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 17160444.001).
  • [ISSN] 0301-1623
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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69. Vaira M, Scuderi S, Costamagna D, Caponi A, Caponi C, Ciaccio B, Fiorentini G, Bolieraki A, Camassa M, Parma E, Scarcello E, Taddei P, Zappelli I, De Simone M: [Cytoreduction and intraoperative peritoneal chemohyperthermia in carcinomatosis from colonic carcinoma and in peritoneal pseudomyxoma]. Suppl Tumori; 2005 May-Jun;4(3):S116
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  • In this study we consider the carcinomatosis from colorectal and appendiceal adenocarcinoma.
  • [MeSH-major] Carcinoma / secondary. Carcinoma / therapy. Chemotherapy, Cancer, Regional Perfusion. Colonic Neoplasms / pathology. Hyperthermia, Induced. Peritoneal Neoplasms / secondary. Peritoneal Neoplasms / therapy. Pseudomyxoma Peritonei / therapy

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  • (PMID = 16437941.001).
  • [ISSN] 2283-5423
  • [Journal-full-title] I supplementi di Tumori : official journal of Società italiana di cancerologia ... [et al.]
  • [ISO-abbreviation] Suppl Tumori
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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70. Tucker ON, Madhavan P, Healy V, Jeffers M, Keane FB: Unusual presentation of an appendiceal malignancy. Int Surg; 2006 Jan-Feb;91(1):57-60
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  • [Title] Unusual presentation of an appendiceal malignancy.
  • Primary malignant epithelial tumors of the appendix are uncommon.
  • The most common presentation of appendiceal malignancy is right lower abdominal pain suggestive of acute appendicitis.
  • We present the case of a 48-year-old woman with an appendiceal malignancy who presented with symptoms and signs suggestive of complicated diverticular disease with an enterovaginal fistula.
  • From a review of the literature, this is the first report of an appendiceal malignancy presenting in this manner.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Appendiceal Neoplasms / diagnosis
  • [MeSH-minor] Diverticulitis / diagnosis. Female. Humans. Intestinal Fistula / diagnosis. Middle Aged. Tomography, X-Ray Computed. Vaginal Fistula / diagnosis

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  • (PMID = 16706105.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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71. Petrou A, Papalambros A, Katsoulas N, Bramis K, Evangelou K, Felekouras E: Primary appendiceal mucinous adenocarcinoma alongside with situs inversus totalis: a unique clinical case. World J Surg Oncol; 2010;8:49
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  • [Title] Primary appendiceal mucinous adenocarcinoma alongside with situs inversus totalis: a unique clinical case.
  • INTRODUCTION: Mucinous adenocarcinoma is a rare neoplasm of the gastrointestinal tract and one of the three major histological subtypes of the primary appendiceal adenocarcinoma.
  • The most common type of presentation is that of acute appendicitis and the diagnosis is usually occurred after appendectomy.
  • The accurate preoperative diagnosis and management of the above condition represents a real challenge when uncommon anatomic anomalies such intestinal malrotation and situs inversus take place.
  • Both preoperative US and CT scan of the abdomen and pelvis declared situs inversus, with a characteristic thickening in its wall, appendix situated in the left lower quadrant of the abdomen.
  • These findings reached to the diagnosis of acute appendicitis with situs inversus and a standard appendicectomy was performed.
  • Pathologic evaluation established primary mucinous adenocarcinoma of the appendix and three months afterwards the patient underwent a subsequent extended left hemicolectomy.
  • CONCLUSION: In conclusion, the occurrence of primary appendiceal mucinous adenocarcinoma along with situs inversus, definitely accounts as a unique clinical case.
  • Even synchronous manifestation of primary mucinous adenocarcinoma of the appendix and situs inversus totalis represents an unusual anatomo-pathological entity, all physicians should be familiar having the knowledge to make an appropriate and accurate diagnosis that will lead to prompt and correct treatment.
  • [MeSH-major] Adenocarcinoma, Mucinous / complications. Appendiceal Neoplasms / complications. Situs Inversus / complications

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  • (PMID = 20525349.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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  • [Other-IDs] NLM/ PMC2894825
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72. O'Donnell ME, Badger SA, Beattie GC, Carson J, Garstin WI: Malignant neoplasms of the appendix. Int J Colorectal Dis; 2007 Oct;22(10):1239-48
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant neoplasms of the appendix.
  • BACKGROUND: Appendiceal neoplasms, first described in 1882, are still rare, with pre-operative diagnosis invariably difficult.
  • A literature search of the PubMed database was then performed using the medical search headings; appendix, tumour, neoplasm and malignancy.
  • Other appendiceal pathologies were identified after appendicectomies, hemicolectomy and oophorectomy.
  • Patients with classical carcinoid tumours (CCT) had better outcomes than patients with the goblet cell carcinoid, adenocarcinoma and lymphoma.
  • CONCLUSIONS: From our own experience and a subsequent review of the literature, we recommend right hemicolectomy as the treatment of choice for all malignant appendiceal neoplasms, except for small CCT less than 2 cm in diameter at the tip of the appendix, with a low proliferative index, without angiolymphatic or mesoappendiceal extension.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Appendiceal Neoplasms / therapy

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  • (PMID = 17447078.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] Germany
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73. Graziani R, Brandalise A, Bellotti M, Manfredi R, Contro A, Falconi M, Boninsegna L, Pozzi Mucelli R: Imaging of neuroendocrine gastroenteropancreatic tumours. Radiol Med; 2010 Oct;115(7):1047-64
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  • Radiological detection of carcinoid tumours is limited by typical tumour location throughout the gastrointestinal tract or appendix and is therefore dependent on the tumour being large enough to make it recognisable in that site.
  • Rather, its role is to characterise the tumour and, in particular, to differentiate pancreatic NFET from ductal adenocarcinoma, as in comparison, malignant NFETs have a more favourable prognosis (5-year survival rate 40% compared with 3%-5% for adenocarcinoma) and therefore require different treatment approaches.
  • [MeSH-major] Intestinal Neoplasms / diagnosis. Neuroendocrine Tumors / diagnosis. Pancreatic Neoplasms / diagnostic imaging. Stomach Neoplasms / diagnosis

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  • (PMID = 20221711.001).
  • [ISSN] 1826-6983
  • [Journal-full-title] La Radiologia medica
  • [ISO-abbreviation] Radiol Med
  • [Language] eng; ita
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
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74. Stinner B, Rothmund M: Neuroendocrine tumours (carcinoids) of the appendix. Best Pract Res Clin Gastroenterol; 2005 Oct;19(5):729-38
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  • [Title] Neuroendocrine tumours (carcinoids) of the appendix.
  • Neuroendocrine tumours (NETs) of the appendix (formerly 'carcinoids') are rare and are usually detected incidentally after appendectomy.
  • They are preferentially located at the tip of the appendix.
  • Goblet-cell carcinoids have features resembling both carcinoid and adenocarcinoma and should be treated by hemicolectomy.
  • Overall prognosis of small appendiceal NET is excellent in all ages.
  • [MeSH-major] Appendectomy / methods. Appendiceal Neoplasms / pathology. Appendiceal Neoplasms / surgery. Carcinoid Tumor / pathology. Carcinoid Tumor / surgery. Neoplasm Invasiveness / pathology

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  • (PMID = 16253897.001).
  • [ISSN] 1521-6918
  • [Journal-full-title] Best practice & research. Clinical gastroenterology
  • [ISO-abbreviation] Best Pract Res Clin Gastroenterol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 32
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75. Pahlavan PS, Kanthan R: The epidemiology and clinical findings of colorectal cancer in Iran. J Gastrointestin Liver Dis; 2006 Mar;15(1):15-9
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  • [Title] The epidemiology and clinical findings of colorectal cancer in Iran.
  • BACKGROUND: This study was performed to evaluate the prevalence, clinical features and management of patients with colorectal cancer (CRC) in Iran.
  • The tumors were categorized according to their distribution as appendix (n=4), cecum ( n=7), right colon (n=1), hepatic flexure (n=2), transverse colon (n=19), splenic flexure (n=3), left colon (n=6), sigmoid ( n=16), rectum (n=117), rectosigmoid and rectal lesions (n=16), and colorectal lesions without known locations (n=9).
  • Non-mucinous adenocarcinoma (AC) was the most common histological type (n=181, 90%), followed by mucinous AC (n=15), squamous cell carcinoma (n=1), carcinoid (n=1), melanoma (n=1) and signet ring carcinoma (n=1).
  • We found no significant difference between age, gender and type of cancer with subsite distribution.

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  • (PMID = 16680227.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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76. Ahmad J, Andrabi SI, Thekkinkattil DK, Rathore MA: Adenocarcinoid tumour of the appendix masquerading as acute appendicitis: a word of caution. Ulus Travma Acil Cerrahi Derg; 2008 Apr;14(2):167-9
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  • [Title] Adenocarcinoid tumour of the appendix masquerading as acute appendicitis: a word of caution.
  • Adenocarcinoids are rare and aggressive tumors with histological features of both carcinoid tumor and adenocarcinoma.
  • We report a case of a 32-year-old man with diffuse infiltration of the appendix wall and mesoappendix by an adenocarcinoid.
  • We suggest that patients with diffuse appendiceal involvement require an aggressive surgical therapy and follow-up.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Carcinoid Tumor / diagnosis
  • [MeSH-minor] Adult. Appendicitis / diagnosis. Diagnosis, Differential. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 18523911.001).
  • [ISSN] 1306-696X
  • [Journal-full-title] Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES
  • [ISO-abbreviation] Ulus Travma Acil Cerrahi Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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77. Bodin R, Peycru T, Schwartz A, Jarry J, Pommier N, Durand-Dastes F: Tubulovillous adenoma of the appendix: a case report and review of the literature. Gastroenterol Clin Biol; 2010 Nov;34(11):633-5
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  • [Title] Tubulovillous adenoma of the appendix: a case report and review of the literature.
  • Treatment is most often limited to appendectomy, but in the event of incomplete excision or associated adenocarcinoma, right hemicolectomy may be required.
  • [MeSH-major] Adenoma, Villous / surgery. Appendectomy. Appendiceal Neoplasms / surgery

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20739133.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] France
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78. Akbulut S, Ulku A, Senol A, Tas M, Yagmur Y: Left-sided appendicitis: review of 95 published cases and a case report. World J Gastroenterol; 2010 Nov 28;16(44):5598-602
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  • The diagnosis was established preoperatively in 49 patients, intraoperatively in 19, and during the postoperative period in five; 14 patients were aware of having this anomaly.
  • Histopathological examination of the appendix specimens revealed adenocarcinoma in only two of 95 patients.
  • CONCLUSION: The diagnosis of left lower quadrant pain is based on well-established clinical symptoms, physical examination and physician's experience.
  • [MeSH-major] Appendicitis / complications. Appendix / abnormalities. Situs Inversus / complications

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  • (PMID = 21105193.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2992678
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79. Soto Delgado M, Pedrero Márquez G, Varo Solís C, Rodríguez-Rubio Cortadellas FO, Sánchez Bernal C, González Moreno D: [Mucinous adenocarcinoma of the urachus and peritoneal pseudomyxoma]. Actas Urol Esp; 2006 Feb;30(2):222-6
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  • [Title] [Mucinous adenocarcinoma of the urachus and peritoneal pseudomyxoma].
  • [Transliterated title] Adenocarcinoma mucinoso de uraco y pseudomixoma peritoneal.
  • The adenocarcinoma of the urachus is very rare tumor, with an incidence of 1/5.000.000 inhabitants, represents less than 0.001 of all types of bladder cancer.
  • Usually is associated with benign o malignant mucinous tumor of the appendix or ovary.
  • In this paper, we present a case of peritoneal pseudomixoma caused by a mucinous adenocarcinoma of the urachus.
  • [MeSH-major] Adenocarcinoma, Mucinous / complications. Pseudomyxoma Peritonei / etiology. Urachus

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  • (PMID = 16700214.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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80. Misdraji J: Appendiceal mucinous neoplasms: controversial issues. Arch Pathol Lab Med; 2010 Jun;134(6):864-70
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  • [Title] Appendiceal mucinous neoplasms: controversial issues.
  • Low grade appendiceal mucinous neoplasms can spread to the peritoneum as pseudomyxoma peritonei even though they are not obviously invasive in the appendix.
  • During the past several decades, several problematic issues surrounding this enigmatic tumor have been debated in the literature, including appropriate nomenclature for the appendiceal tumors and their peritoneal metastases.
  • In this article, the most contentious issues in the area of appendiceal mucinous tumors are examined.
  • First, the classification systems that have been proposed for these tumors are compared in the context of whether the appendiceal mucinous tumors are ruptured adenomas or invasive carcinomas.
  • Next reviewed is the largely resolved controversy about whether ovarian mucinous tumors in this setting are separate primaries or are metastases from the appendiceal tumor.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Appendiceal Neoplasms / diagnosis. Pseudomyxoma Peritonei / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / pathology. Ovarian Neoplasms / secondary. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / secondary. Peritoneal Neoplasms / therapy

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  • (PMID = 20524864.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 36
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81. Subramanya D, Grivas PD, Styler M: Appendiceal carcinoma: a diagnostic and therapeutic challenge. Postgrad Med; 2008 Nov;120(4):95-100
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  • [Title] Appendiceal carcinoma: a diagnostic and therapeutic challenge.
  • Appendiceal carcinoma is a very rare clinical entity, constituting 1% of all colorectal malignancies and 1% of all appendectomy specimens.
  • Appendiceal malignancies often present atypically, thus creating diagnostic challenges.
  • We present a patient with mucinous carcinoma of the appendix who presented with hematuria and abdominal pain.
  • Similar case reports are extremely rare in the literature, while typical presentations of appendiceal carcinoma include abdominal pain, abdominal mass, early satiety, nausea, and iron-deficiency anemia.
  • Initially, the diagnostic investigation in our patient was focused on urinary tract disorders, but ultimately resulted in finding a mucinous appendiceal carcinoma.
  • An integrative approach is required in the diagnostic investigation and management of appendiceal malignancies.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / surgery. Appendiceal Neoplasms / diagnosis. Appendiceal Neoplasms / surgery

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  • (PMID = 19020371.001).
  • [ISSN] 1941-9260
  • [Journal-full-title] Postgraduate medicine
  • [ISO-abbreviation] Postgrad Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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82. Miyakura Y, Iwai H, Togashi K, Horie H, Nagai H, Kishaba Y, Sato K, Azuma H: Mucinous cystadenocarcinoma of the appendix invading the ascending colon with fistula formation: report of a case. Surg Today; 2007;37(9):806-10
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  • [Title] Mucinous cystadenocarcinoma of the appendix invading the ascending colon with fistula formation: report of a case.
  • Based on colonoscopy findings, we made a preoperative diagnosis of primary mucinous cystadenocarcinoma of the appendix with features of a submucosal tumor (SMT) in the ascending colon.
  • Examination of colonoscopic biopsy specimens indicated "very" well-differentiated adenocarcinoma with mucus lakes.
  • The adjacent appendix had an enhanced wall and unclear border against the ascending colon.
  • Histopathological examination revealed mucinous cystadenocarcinoma of the appendix, invading the ascending colon with fistula formation.
  • Appendiceal tumors can manifest with a variety of colonoscopic features, and curative surgical resection should be attempted even if there is fistula formation.
  • [MeSH-major] Appendix / pathology. Colon / pathology. Colonic Diseases / etiology. Cystadenocarcinoma, Mucinous / complications. Intestinal Fistula / etiology. Mucins

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  • (PMID = 17713739.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Mucins
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83. Terada T: Non-invasive Adenocarcinoma of the Vermiform Appendix: Incidence and Report of Four Cases among 512 Appendectomies. Gastroenterology Res; 2009 Aug;2(4):238-241
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Non-invasive Adenocarcinoma of the Vermiform Appendix: Incidence and Report of Four Cases among 512 Appendectomies.
  • : Tumors of the vermiform appendix are relatively rare.
  • More than 50% of appendiceal tumors are carcinoid tumors.
  • The author reviewed 512 consecutive pathological specimens of appendectomies in last ten years in our pathology laboratory in search for appendiceal tumors.
  • As the results, 4 cases (incidence: 0.8%) of non-invasive adenocarcinoma were found.
  • The age of the 4 patients with adenocarcinoma was 48, 39, 84 and 86 years, respectively.
  • Pathologically, all the 4 tumors were non-invasive adenocarcinomas: 2 cases were flat type adenocarcinoma, 1 case was papillary adenocarcinoma, and 1 case was mucinous adenocarcinoma.
  • The results suggest that incidence of appendiceal adenocarcinoma was 0.8% of all appendectomies, and that non-invasive adenocarcinoma of the appendix shows variable morphologies, and that postoperative clinical outcome of non-invasive appendiceal tumor is good.

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  • (PMID = 27942282.001).
  • [ISSN] 1918-2805
  • [Journal-full-title] Gastroenterology research
  • [ISO-abbreviation] Gastroenterology Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Keywords] NOTNLM ; Adenocarcinoma / Appendix / Histopathology / Non-invasive carcinoma / appendicitis
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84. Hemakini, Kaur H, Khadilkar U, Rau AR, Rao HT, Tantry BV: "The inside out appendix"--report of 2 cases. Trop Gastroenterol; 2010 Jan-Mar;31(1):55-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] "The inside out appendix"--report of 2 cases.
  • [MeSH-major] Adenocarcinoma / surgery. Adenoma / surgery. Appendiceal Neoplasms / surgery. Intussusception / surgery
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 20860233.001).
  • [ISSN] 0250-636X
  • [Journal-full-title] Tropical gastroenterology : official journal of the Digestive Diseases Foundation
  • [ISO-abbreviation] Trop Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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85. Semino-Mora C, Liu H, McAvoy T, Nieroda C, Studeman K, Sardi A, Dubois A: Pseudomyxoma peritonei: is disease progression related to microbial agents? A study of bacteria, MUC2 AND MUC5AC expression in disseminated peritoneal adenomucinosis and peritoneal mucinous carcinomatosis. Ann Surg Oncol; 2008 May;15(5):1414-23
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  • BACKGROUND AND AIMS: Pseudomyxoma peritonei (PMP) is characterized by peritoneal tumors arising from a perforated appendiceal adenoma or adenocarcinoma, but associated entry of enteric bacteria in the peritoneum has not been considered as a cofactor.
  • METHODS: In situ hybridization was performed on resection specimens from five control subjects with noninflamed, nonperforated, non-neoplastic appendix and 16 patients with PMP [six with disseminated peritoneal adenomucinosis (DPAM) and 10 with peritoneal mucinous carcinomatosis (PMCA)].

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  • (PMID = 18299935.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA082312-08; United States / NCI NIH HHS / CA / R01 CA082312; United States / NCI NIH HHS / CA / CA82312; United States / NCI NIH HHS / CA / R01 CA082312-08
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA Probes; 0 / MUC2 protein, human; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucin-2; 0 / Mucins; 0 / RNA Probes
  • [Other-IDs] NLM/ NIHMS72052; NLM/ PMC2570966
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86. Wu CL, Yu CC: Amyand's hernia with adenocarcinoid tumor. Hernia; 2010 Aug;14(4):423-5
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  • Also, neoplasms of the appendix is quite uncommon.
  • Adenocarcinoid tumor of the appendix was noted after the operation.
  • [MeSH-major] Appendiceal Neoplasms / complications. Appendicitis / complications. Hernia, Inguinal / complications
  • [MeSH-minor] Adenocarcinoma / complications. Adenocarcinoma / surgery. Appendectomy. Colectomy. Humans. Male. Middle Aged

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  • (PMID = 19756915.001).
  • [ISSN] 1248-9204
  • [Journal-full-title] Hernia : the journal of hernias and abdominal wall surgery
  • [ISO-abbreviation] Hernia
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] Adenocarcinoid tumor
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87. Stewart JH 4th, Shen P, Russell GB, Bradley RF, Hundley JC, Loggie BL, Geisinger KR, Levine EA: Appendiceal neoplasms with peritoneal dissemination: outcomes after cytoreductive surgery and intraperitoneal hyperthermic chemotherapy. Ann Surg Oncol; 2006 May;13(5):624-34
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  • [Title] Appendiceal neoplasms with peritoneal dissemination: outcomes after cytoreductive surgery and intraperitoneal hyperthermic chemotherapy.
  • BACKGROUND: Appendiceal neoplasms frequently present with peritoneal dissemination (PD) and have a clinical course marked by bowel obstruction and subsequent death.
  • Few data have correlated outcome with appendiceal histology after cytoreductive surgery and intraperitoneal hyperthermic chemotherapy (IPHC).
  • We have reviewed our experience with cytoreductive surgery and IPHC for PD from the appendix.
  • METHODS: A total of 110 cases of PD from proven appendiceal neoplasms treated with IPHC were identified from a prospectively managed database.
  • RESULTS: A total of 116 IPHCs were performed on 110 patients for appendiceal PD between 1993 and 2004.
  • Age at presentation (P = .0134), performance status (P < .0001), time between diagnosis and IPHC (P = .0011), resection status (P = .0044), and length of hyperthermic chemoperfusion (P = .0193) were independently associated with survival.
  • CONCLUSIONS: The data show that long-term survival is anticipated in most patients who are treated with cytoreduction and IPHC for appendiceal PD.
  • In all, this work establishes a framework for the consideration of IPHC in future trials for appendiceal PD.
  • [MeSH-major] Adenocarcinoma, Mucinous / drug therapy. Adenocarcinoma, Mucinous / surgery. Appendiceal Neoplasms / pathology. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / surgery

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  • [CommentIn] Ann Surg Oncol. 2006 May;13(5):597-9 [16538404.001]
  • (PMID = 16538401.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / K08 CA131482
  • [Publication-type] Journal Article
  • [Publication-country] United States
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88. Woei Chung L, Liao YM, Hsieh CY, Lin CY: Oxaliplatin-induced long QT syndrome in a patient with appendiceal adenocarcinoma. Acta Oncol; 2009;48(1):156-7
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  • [Title] Oxaliplatin-induced long QT syndrome in a patient with appendiceal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / drug therapy. Appendiceal Neoplasms / drug therapy. Long QT Syndrome / chemically induced. Organoplatinum Compounds / adverse effects

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  • Hazardous Substances Data Bank. FLUOROURACIL .
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  • (PMID = 18618340.001).
  • [ISSN] 1651-226X
  • [Journal-full-title] Acta oncologica (Stockholm, Sweden)
  • [ISO-abbreviation] Acta Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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89. van Huisseling H, van Hanegem L, van Dijk M: Post-menopausal vaginal bleeding caused by carcinoma of the appendix: a case report. J Med Case Rep; 2010;4:127
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  • [Title] Post-menopausal vaginal bleeding caused by carcinoma of the appendix: a case report.
  • The most frequent malignancy found in cases of post-menopausal bleeding is endometrial cancer.
  • To the best of our knowledge, it appears that this is the first published case of a post-menopausal primary appendiceal carcinoma presenting with vaginal blood loss.
  • Microscopic examination of the tissue removed at laparotomy revealed an adenocarcinoma of the appendix.

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  • (PMID = 20433768.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2873455
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90. Goere D, Elias D: [Appendiceal tumors found at appendectomy]. J Chir (Paris); 2009 Oct;146 Spec No 1:36-8
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  • [Title] [Appendiceal tumors found at appendectomy].
  • [Transliterated title] Diagnostic de tumeur appendiculaire lors d'une appendicectomie.
  • There are three main histologic types of appendiceal tumor: adenoma, adenocarcinoma, and neuroendocrine tumor.
  • Neuroendocrine tumors (carcinoids) are by far the most common and account for two-third of all appendiceal tumors.
  • For unruptured appendiceal tumor, the appendix should be removed by a carcinologic right hemicolectomy if the tumor appears aggressive.
  • [MeSH-major] Appendectomy. Appendiceal Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Adenoma / diagnosis. Adenoma / surgery. Humans. Neuroendocrine Tumors / diagnosis. Neuroendocrine Tumors / surgery. Peritoneal Neoplasms / prevention & control. Pseudomyxoma Peritonei / prevention & control. Rupture / prevention & control

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  • (PMID = 19846099.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 7
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91. Rezkalla MA, Peterson KG, Ryan JJ: Pseudomyxoma peritonei: a case of mucinous adenocarcinoma of the appendix presenting as inguinal hernia. S D Med; 2006 Feb;59(2):54-5, 57
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  • [Title] Pseudomyxoma peritonei: a case of mucinous adenocarcinoma of the appendix presenting as inguinal hernia.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Appendiceal Neoplasms / diagnosis. Hernia, Inguinal / diagnosis. Peritoneal Neoplasms / diagnosis. Pseudomyxoma Peritonei / diagnosis

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  • (PMID = 16519367.001).
  • [ISSN] 0038-3317
  • [Journal-full-title] South Dakota medicine : the journal of the South Dakota State Medical Association
  • [ISO-abbreviation] S D Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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92. Hsu KH, Chou CY, Chang YC: Intraperitoneal hyperthermia in the management of pseudomyxoma peritonei. Hepatogastroenterology; 2007 Jan-Feb;54(73):47-52
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  • RESULTS: The appendix was the origin of pseudomyxoma peritonei in 6 patients, the ovary in 1 patient, and the fallopian tube in another.
  • The pathologic diagnosis was mucinous adenocarcinoma in 4 patients, mucinous cystadenocarcinoma in 3, and mucinous cystadenoma in 1.

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  • (PMID = 17419229.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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93. McQuellon RP, Danhauer SC, Russell GB, Shen P, Fenstermaker J, Stewart JH, Levine EA: Monitoring health outcomes following cytoreductive surgery plus intraperitoneal hyperthermic chemotherapy for peritoneal carcinomatosis. Ann Surg Oncol; 2007 Mar;14(3):1105-13
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  • The questionnaire consisted of basic demographic items as well as the Functional Assessment of Cancer Therapy-Colon Scale (FACT-C), SF-36 Medical Outcomes Study Health Survey, Center for Epidemiologic Studies-Depression Scale (CES-D), Brief Pain Inventory-Short Form, and ECOG Performance Status Rating.
  • PC originated in primary lesions of the appendix (n = 36); colon/rectum (n = 24); mesothelium (n = 9); ovary (n = 5); stomach (n = 4); and miscellaneous (n = 18).
  • [MeSH-major] Adenocarcinoma / therapy. Chemotherapy, Cancer, Regional Perfusion. Hyperthermia, Induced. Peritoneal Neoplasms / therapy

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  • (PMID = 17206478.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / K08 CA131482
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 50SG953SK6 / Mitomycin
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94. Yan TD, Brun EA, Sugarbaker PH: Discordant histology of primary appendiceal adenocarcinoid neoplasms with peritoneal dissemination. Ann Surg Oncol; 2008 May;15(5):1440-6
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  • [Title] Discordant histology of primary appendiceal adenocarcinoid neoplasms with peritoneal dissemination.
  • BACKGROUND: Adenocarcinoid is a rare appendiceal tumor that shows histologically both epithelial and neuroendocrine components.
  • We observed that some patients have peritoneal dissemination, which shows adenocarcinoma but lacks the neuroendocrine histology.
  • METHODS: Twenty-six patients with peritoneal dissemination from primary appendiceal adenocarcinoid tumors underwent cytoreductive surgery and perioperative intraperitoneal chemotherapy.
  • RESULTS: In nine of the 26 patients (35%) with a primary adenocarcinoid of the appendix, a loss of the neuroendocrine immunochemical marker was noted in peritoneal implants.
  • Discordant histology between the primary appendiceal adenocarcinoid and the peritoneal implants was statistically significantly associated with an improved survival (p = 0.0262), when patients were treated by cytoreductive surgery and perioperative intraperitoneal chemotherapy.
  • CONCLUSIONS: Discordant histology of the primary appendiceal tumor as compared to the peritoneal lesions occurs frequently in patients with adenocarcinoid.
  • [MeSH-major] Adenocarcinoma / secondary. Appendiceal Neoplasms / pathology. Carcinoid Tumor / secondary. Peritoneal Neoplasms / secondary

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  • (PMID = 18299936.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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95. Thirunavukarasu P, Sathaiah M, Singla S, Sukumar S, Karunamurthy A, Pragatheeshwar KD, Lee KK, Zeh H 3rd, Kane KM, Bartlett DL: Medullary carcinoma of the large intestine: a population based analysis. Int J Oncol; 2010 Oct;37(4):901-7
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  • Medullary carcinoma (MC) of the colorectum is a relatively new histological type of adenocarcinoma characterized by poor glandular differentiation and intraepithelial lymphocytic infiltrate.
  • Mean age at diagnosis was 69.3 (+/-12.5) years, with incidence increasing with age.
  • There were no cases reliably identified in the rectum or appendix.
  • [MeSH-major] Adenocarcinoma / epidemiology. Carcinoma, Medullary / epidemiology. Colorectal Neoplasms / epidemiology

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  • (PMID = 20811712.001).
  • [ISSN] 1791-2423
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / T32 CA113263
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
  • [Other-IDs] NLM/ NIHMS609288; NLM/ PMC4127912
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96. Suzuki J, Kazama S, Kitayama J, Uozaki H, Miyata T, Nagawa H: Signet ring cell carcinoma of the appendix manifesting as colonic obstruction and ovarian tumors: report of a case. Surg Today; 2009;39(3):235-40
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  • [Title] Signet ring cell carcinoma of the appendix manifesting as colonic obstruction and ovarian tumors: report of a case.
  • Appendiceal cancer is rare and associated with a poor prognosis because it is usually found at an advanced stage.
  • We report a case of appendiceal adenocarcinoma manifesting as a colonic obstruction with a lower abdominal mass.
  • Laparotomy revealed bilateral ovarian tumors and a small appendiceal tumor with peritoneal metastases.
  • We performed ileocecal resection, colectomy, and oophorectomy, following which a histological diagnosis of signet ring cell carcinoma was made.
  • Immunohistochemical analysis revealed positive expression of cytokeratin 7 and 20, and mucin core protein 2 (MUC2), compatible with appendiceal cancer and Kruckenberg metastases.
  • When a patient is found to have disseminated pelvic signet ring cell carcinoma of unknown origin, the appendix should be considered as a possible primary site.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoma, Signet Ring Cell / pathology. Intestinal Obstruction / etiology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers / analysis. Female. Humans. Magnetic Resonance Imaging. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / secondary. Peritoneal Neoplasms / surgery. Tomography, X-Ray Computed


97. Barry M, Collins CG, McCawley N, McGuinness J, Leahy AL: Synchronous appendiceal tumours. Surgeon; 2007 Apr;5(2):111-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronous appendiceal tumours.
  • Primary appendiceal neoplasms are a rare clinical and pathological entity.
  • We report a case of synchronous appendiceal tumours of different histological types which presented as a symptomatic palpable and radiologically apparent mass in the right iliac fossa.
  • This case demonstrates the importance of pre-operative diagnosis of these neoplasms, as it may alter the surgical approach and obviate the need for additional surgery.
  • Furthermore, some of the controversies associated with the management of an appendix mass in the elderly population are discussed.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 17450695.001).
  • [ISSN] 1479-666X
  • [Journal-full-title] The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
  • [ISO-abbreviation] Surgeon
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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98. Umemoto M, Shiota M, Shimaoka M, Hoshiai H: Definitive diagnosis of primary adenocarcinoma of the appendix by laparoscopic appendectomy. J Obstet Gynaecol Res; 2007 Aug;33(4):590-4
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  • [Title] Definitive diagnosis of primary adenocarcinoma of the appendix by laparoscopic appendectomy.
  • We report a 62-year-old woman with a primary adenocarcinoma of the appendix mimicking ovarian tumor.
  • However, the present case suggests that, in some cases, if cancer of the appendix can be diagnosed early, laparotomy can be avoided and the cancer treated with minimally invasive laparoscopic surgery alone.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology

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  • (PMID = 17688638.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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99. Tang LH: Epithelial neoplasms of the appendix. Arch Pathol Lab Med; 2010 Nov;134(11):1612-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelial neoplasms of the appendix.
  • CONTEXT: The appendix gives rise to an array of epithelial neoplasms showing glandular or neuroendocrine differentiation, and some tumors with elements of both cell types.
  • Although some appendiceal neoplasms resemble their counterparts in the small and large intestines (conventional adenocarcinoma and carcinoid tumor), the appendix also gives rise to relatively unique entities including mucinous neoplasms and goblet cell carcinoid tumors, which present a challenge in pathologic classification and clinical management.
  • OBJECTIVE: To review clinical and diagnostic issues for 3 pathologic types of epithelial neoplasms of the appendix:.
  • (1) adenocarcinoma, with specific focus on mucinous neoplasm;.
  • (2) goblet cell carcinoid tumor and associated adenocarcinoma; and (3) typical carcinoid tumor.
  • CONCLUSIONS: The most important issue in pathologic assessment of epithelial tumors of the appendix is to understand the clinical implications inherent in the diagnosis.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Appendix / pathology. Carcinoid Tumor / pathology

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  • (PMID = 21043814.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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100. Samet I, Cormier B, Mowlawi H, Philippe A, Arbion F, Fétissof F: [Endometrial and endocervical lesions associated with pseudomyxoma peritonei: a case report]. Ann Pathol; 2009 Jun;29(3):233-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The association of a pseudomyxoma peritonei with a mucinous tumor of the appendix and/or the ovary is regularly reported in the literature.
  • We report the case of a 57-year-old patient, with pseudomyxoma peritonei associated with a low-grade mucinous neoplasia of appendix and both ovaries.
  • Histological and immunohistochemical characteristics of this epithelium were quite comparable to those observed in the appendix and ovaries.
  • The endocervical and endometrial lesions might represent an implantation of mucinous epithelium from appendix, emphasizing the capacity of this epithelium to implant at a distance from the original lesion.
  • [MeSH-major] Adenocarcinoma, Mucinous / complications. Appendiceal Neoplasms / complications. Cervix Uteri / pathology. Endometrium / pathology. Neoplasms, Multiple Primary / pathology. Ovarian Neoplasms / complications. Pseudomyxoma Peritonei / etiology
  • [MeSH-minor] Appendectomy. Breast Neoplasms / diagnosis. Carcinoma, Ductal, Breast / diagnosis. Epithelial Cells / pathology. Female. Humans. Hysterectomy. Metaplasia. Middle Aged. Neoplasm Invasiveness. Ovariectomy






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