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Items 1 to 28 of about 28
1. Sen M, Ozdemir O, Turan M, Arici S, Yildiz F, Koksal B, Goze F: Epigenetic inactivation of tumor suppressor SFRP2 and point mutation in KRAS proto-oncogene in fistula-associated mucinous type anal adenocarcinoma: report of two cases. Intern Med; 2010;49(15):1637-40
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  • [Title] Epigenetic inactivation of tumor suppressor SFRP2 and point mutation in KRAS proto-oncogene in fistula-associated mucinous type anal adenocarcinoma: report of two cases.
  • The aim of the current study was to clarify whether SFRP2 methylation and K-ras structural mutation in fecal DNA can be found in stool and tumoral tissues of individuals with fistula-associated mucinous type anal adenocarcinomas (MTAA).Two man patients (68 and 56 years old) were treated for anorectal fistula in the surgical department.
  • The current results showed that the combined effects of somatic mutations in K-ras and epigenetic alterations in SFRP2 genes may play an active role in the development of mucinous type anal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / genetics. Anus Neoplasms / genetics. Membrane Proteins / genetics. Point Mutation / genetics. Proto-Oncogene Proteins / genetics. Rectal Fistula / genetics. ras Proteins / genetics

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  • (PMID = 20686305.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / KRAS protein, human; 0 / Membrane Proteins; 0 / Proto-Oncogene Proteins; 0 / SFRP2 protein, human; EC 3.6.5.2 / ras Proteins
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2. Ibáñez J, Erro JM, Aranda F, Almendral ML, Valenti C, Echenique-Elizondo M: [Mucinous adenocarcinoma on chronic perianal fistula treated by neoadjuvant chemoradiotherapy and laparoscopy-assisted abdominoperineal amputation]. Cir Esp; 2006 Mar;79(3):184-5
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  • [Title] [Mucinous adenocarcinoma on chronic perianal fistula treated by neoadjuvant chemoradiotherapy and laparoscopy-assisted abdominoperineal amputation].
  • [Transliterated title] Adenocarcinoma mucinoso en fístula perianal de largo tiempo de evolución tratado mediante QT-RT neoadyuvante y amputación abdominoperineal laparoscópica.
  • The patient presented with mucoid anal adenocarcinoma.
  • Mucoid adenocarcinoma on chronic perianal fistula is an infrequent process.
  • Late diagnosis is associated with a poor prognosis.
  • [MeSH-major] Adenocarcinoma, Mucinous / complications. Adenocarcinoma, Mucinous / therapy. Antimetabolites, Antineoplastic / therapeutic use. Anus Neoplasms / complications. Anus Neoplasms / therapy. Fluorouracil / therapeutic use. Laparoscopy. Leucovorin / therapeutic use. Rectal Fistula / complications

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  • (PMID = 16545286.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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3. Han C, Chen YJ, Liu A, Schultheiss TE, Wong JY: Dosimetric study and in-vivo dose verification for conformal avoidance treatment of anal adenocarcinoma using helical tomotherapy. Med Dosim; 2007;32(1):33-7
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  • [Title] Dosimetric study and in-vivo dose verification for conformal avoidance treatment of anal adenocarcinoma using helical tomotherapy.
  • This study evaluated the efficacy of using helical tomotherapy for conformal avoidance treatment of anal adenocarcinoma.
  • We retrospectively generated step-and-shoot intensity-modulated radiotherapy (sIMRT) plans and helical tomotherapy plans for two anal cancer patients, one male and one female, who were treated by the sIMRT technique.
  • In-vivo skin dose measurements were performed during conformal avoidance helical tomotherapy treatment of an anal cancer patient to verify adequate delivery of skin dose and sparing of OARs.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Anus Neoplasms / radiotherapy. Radiotherapy, Intensity-Modulated / methods. Tomography, Spiral Computed / methods

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  • (PMID = 17317533.001).
  • [ISSN] 0958-3947
  • [Journal-full-title] Medical dosimetry : official journal of the American Association of Medical Dosimetrists
  • [ISO-abbreviation] Med Dosim
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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4. Chang GJ, Gonzalez RJ, Skibber JM, Eng C, Das P, Rodriguez-Bigas MA: A twenty-year experience with adenocarcinoma of the anal canal. Dis Colon Rectum; 2009 Aug;52(8):1375-80
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  • [Title] A twenty-year experience with adenocarcinoma of the anal canal.
  • PURPOSE: Adenocarcinoma of the anal canal is a rare malignancy with limited data regarding treatment and outcomes.
  • The purpose of this study is to evaluate disease control and survival outcomes in patients with adenocarcinoma of the anal canal.
  • METHODS: A retrospective consecutive cohort study of all patients in whom adenocarcinoma of the anal canal was diagnosed between 1983 and 2004 was performed.
  • CONCLUSION: Combined modality treatment with radical surgical resection improves survival among patients with adenocarcinoma of the anal canal, but a high risk for distant failure emphasizes the need for effective adjuvant therapeutic regimens.
  • [MeSH-major] Adenocarcinoma / epidemiology. Anus Neoplasms / epidemiology

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  • (PMID = 19617747.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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5. Gu J, Li J, Yao Y, Lu A, Wang H: Synchronous rectal adenocarcinoma and anal canal adenocarcinoma. Front Med China; 2007 Jul;1(3):333-7
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  • [Title] Synchronous rectal adenocarcinoma and anal canal adenocarcinoma.
  • It is difficult to distinguish a rectal carcinoma with anal metastases from coexistent synchronous anorectal carcinomas.
  • The therapeutic strategy for rectal and anal carcinoma is so different that it should be clearly identified.
  • Here, we report on the case of a 63-year-old man who presented with an upper-third rectal adenocarcinoma.
  • Five months after resection, he developed an adenocarcinoma in the anal canal.
  • For this reason, we believe the present case had synchronous adenocarcinomas arising from anal canal and the rectum separately.
  • It is very important to differentiate the anorectal lesions pathologically because of the impact on the therapeutic options available, especially for the lesion arising in the anal canal.

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  • (PMID = 24573877.001).
  • [ISSN] 1673-7342
  • [Journal-full-title] Frontiers of medicine in China
  • [ISO-abbreviation] Front Med China
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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6. Chia CS, Chew MH, Chau YP, Eu KW, Ho KS: Adenocarcinoma of the anal transitional zone after double stapled ileal pouch-anal anastomosis for ulcerative colitis. Colorectal Dis; 2008 Jul;10(6):621-3
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  • [Title] Adenocarcinoma of the anal transitional zone after double stapled ileal pouch-anal anastomosis for ulcerative colitis.
  • The development of adenocarcinoma in the anal transitional zone, after restorative proctocolectomy for ulcerative colitis, is rare.
  • Restorative proctocolectomy and stapled ileal pouch-anal anastomosis without mucosectomy was performed.
  • A poorly differentiated adenocarcinoma in the anal transition zone was diagnosed and she subsequently underwent an abdomino-perineal resection.
  • We also discuss the suggested surveillance for high-risk patients who have undergone an ileal-anal pouch anastomosis.
  • [MeSH-major] Adenocarcinoma / etiology. Anal Canal / surgery. Anastomosis, Surgical. Anus Neoplasms / etiology. Colitis, Ulcerative / surgery. Colonic Pouches

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  • (PMID = 17949443.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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7. Lee J, Corman M: Recurrence of anal adenocarcinoma after local excision and adjuvant chemoradiation therapy: report of a case and review of the literature. J Gastrointest Surg; 2009 Jan;13(1):150-4
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  • [Title] Recurrence of anal adenocarcinoma after local excision and adjuvant chemoradiation therapy: report of a case and review of the literature.
  • INTRODUCTION: Tumors arising from the anal canal are rare, comprising 1.5% of all gastrointestinal tumors in the USA.
  • The vast majority of these anal cancers are epidermoid (cloacogenic/basaloid and squamous cell carcinomas), while adenocarcinomas reportedly occur 5% to 19% of the time.
  • Because of its rarity, reports about anal adenocarcinoma are limited to small retrospective studies and case reports.
  • CASE PRESENTATION: We describe a case of recurrent anal adenocarcinoma after conservative management with local excision and adjuvant chemoradiation therapy.
  • [MeSH-major] Adenocarcinoma / surgery. Antineoplastic Agents / therapeutic use. Anus Neoplasms / pathology. Anus Neoplasms / therapy. Colectomy / methods

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  • (PMID = 18810561.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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8. Iesalnieks I, Gaertner WB, Glass H, Strauch U, Hipp M, Agha A, Schlitt HJ: Fistula-associated anal adenocarcinoma in Crohn's disease. Inflamm Bowel Dis; 2010 Oct;16(10):1643-8
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  • [Title] Fistula-associated anal adenocarcinoma in Crohn's disease.
  • BACKGROUND: Adenocarcinoma arising from perianal fistulae in patients with Crohn's disease (CD) is rare.
  • We present 6 patients with CD and fistula-associated anal adenocarcinoma (FAAA) and a systematic review of published series.
  • The average age at time of diagnosis was 45.5 years.
  • Mean delay of cancer diagnosis was 11 months.
  • CONCLUSIONS: Adenocarcinoma arising from long-standing perianal CD fistulae is being increasingly reported.
  • [MeSH-major] Adenocarcinoma, Mucinous / etiology. Anus Neoplasms / etiology. Crohn Disease / complications. Rectal Fistula / etiology


9. Kounalakis N, Artinyan A, Smith D, Mojica-Manoso P, Paz B, Lai LL: Abdominal perineal resection improves survival for nonmetastatic adenocarcinoma of the anal canal. Ann Surg Oncol; 2009 May;16(5):1310-5
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  • [Title] Abdominal perineal resection improves survival for nonmetastatic adenocarcinoma of the anal canal.
  • BACKGROUND: There remains a lack of consensus regarding the optimal treatment for patients with curable adenocarcinoma of the anal canal (AAC).
  • [MeSH-major] Adenocarcinoma / surgery. Anus Neoplasms / surgery. Colectomy / methods

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  • (PMID = 19241106.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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10. Gaertner WB, Hagerman GF, Finne CO, Alavi K, Jessurun J, Rothenberger DA, Madoff RD: Fistula-associated anal adenocarcinoma: good results with aggressive therapy. Dis Colon Rectum; 2008 Jul;51(7):1061-7
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  • [Title] Fistula-associated anal adenocarcinoma: good results with aggressive therapy.
  • PURPOSE: To evaluate the clinical features, pathology, treatment, and outcome of patients with fistula-associated anal adenocarcinoma.
  • METHODS: We identified 14 patients with histologically proven fistula-associated anal adenocarcinoma.
  • The average age at time of diagnosis was 59 (range, 37-76) years.
  • Eleven patients had preexisting chronic anal fistulas.
  • The diagnosis of cancer was suspected during physical examination in 6 of the 14 patients (43 percent).
  • CONCLUSIONS: The diagnosis of fistula-associated anal adenocarcinoma is often unsuspected.
  • [MeSH-major] Adenocarcinoma / therapy. Rectal Fistula / therapy. Rectal Neoplasms / therapy

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  • (PMID = 18418652.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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11. Cohen SJ, Engstrom PF, Lewis NL, Langer CJ, McLaughlin S, Beard M, Weiner LM, Meropol NJ: Phase I study of capecitabine and oxaliplatin in combination with the proteasome inhibitor bortezomib in patients with advanced solid tumors. Am J Clin Oncol; 2008 Feb;31(1):1-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Three objective tumor responses were noted (squamous cell of anus, adenocarcinoma of unknown primary, adenocarcinoma of rectum).

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  • (PMID = 18376220.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA006927
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Boronic Acids; 0 / Organoplatinum Compounds; 0 / Pyrazines; 04ZR38536J / oxaliplatin; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; 69G8BD63PP / Bortezomib; U3P01618RT / Fluorouracil
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12. Yamauchi M, Okamoto Y, Doi M, Shinozaki K: [mFOLFOX6 for treatment of anal canal cancer with disseminated carcinomatosis of bone marrow--a case report]. Gan To Kagaku Ryoho; 2010 Nov;37(11):2209-11
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  • [Title] [mFOLFOX6 for treatment of anal canal cancer with disseminated carcinomatosis of bone marrow--a case report].
  • There was a hard anal mass on rectal examination.
  • Colonoscopy and computed tomography showed anal adenocarcinoma, multiple metastases to lymph nodes and bones.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Anus Neoplasms / drug therapy. Bone Marrow Neoplasms / drug therapy. Carcinoma / drug therapy

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  • (PMID = 21084829.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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13. Yap JC, Yang GY, Fakih M, Mashtare T, Bullard Dunn K, Kuvshinoff BW, Smith J, Khushalani NI, Gibbs JF: Primary adenocarcinoma of the anus: a 22-year SEER population database analysis. J Clin Oncol; 2009 May 20;27(15_suppl):e15072

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary adenocarcinoma of the anus: a 22-year SEER population database analysis.
  • : e15072 Background: Most anal canal cancers consist of squamous cell carcinoma (SCCA).
  • Adenocarcinoma (AdenoCa) is rare and accounts for approximately 10% of anal cancers.
  • METHODS: The search of the SEER database revealed 1,008 pts who had pathologically confirmed anal cancers with either SCCA or AdenoCa.
  • All pts had single diagnosis of anal cancer with localized disease without nodal involvement.
  • On the other hand, among the AdenoCa subset, pts who had APR had better 10-yr OS than RT pts (53.8% vs. 0%, p=0.03) Conclusions: For localized anal SCCA, RT yielded equivalent overall survival as compared to APR.
  • On the other hand, pts with localized anal adenoCa appeared to do worse when APR was omitted.
  • Omission of APR in pts with anal canal adenoCa should be cautiously weighed.

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  • (PMID = 27964572.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Rakoto-Ratsimba HN, Rakototiana AF, Rakotosamimanana J, Ranaivozanany A: [Anal adenocarcinoma revealed by a fistula-in-ano. Report of a case]. Ann Chir; 2006 Nov;131(9):564-6
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  • [Title] [Anal adenocarcinoma revealed by a fistula-in-ano. Report of a case].
  • [Transliterated title] Fistule périanale révélatrice d'un adénocarcinome du canal anal. A propos d'une observation.
  • Anal adenocarcinoma revealed by a fistula-in-ano occurs rarely.
  • Symptomatology has no specificity and the diagnosis is often late, in an advanced stage of the sickness.
  • Recurrent or non recurrent fistula-in-ano requires multiple biopsies for pathology analysis in order to screen a related cancer.
  • [MeSH-major] Adenocarcinoma / complications. Adenocarcinoma / diagnosis. Anus Neoplasms / complications. Anus Neoplasms / diagnosis. Rectal Fistula / complications

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  • (PMID = 16712770.001).
  • [ISSN] 0003-3944
  • [Journal-full-title] Annales de chirurgie
  • [ISO-abbreviation] Ann Chir
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 15
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15. Artioukh DY, Smith RA, Gokul K: Risk factors for impaired healing of the perineal wound after abdominoperineal resection of rectum for carcinoma. Colorectal Dis; 2007 May;9(4):362-7
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  • OBJECTIVE: Nonhealing perineal wound is an unpleasant complication of surgical excision of the rectum and anus.
  • The aim of the study was to evaluate the risk factors for impaired perineal wound healing after abdominoperineal resection (APR) of rectum for adenocarcinoma, particularly with the increasing use of neo-adjuvant chemoradiation.
  • METHOD: The study included 38 consecutive patients (29 men, nine women; median age 66 years, range: 43-86), who underwent surgical excision of rectum and anus for adenocarcinoma from 1999 to 2004.

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  • (PMID = 17432991.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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16. Vietharsdóttir H, Moeller PH, Jóhannsson J, Jónasson JG: [Anal cancer in Iceland 1987-2003. A population based study]. Laeknabladid; 2006 May;92(5):365-72
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  • [Title] [Anal cancer in Iceland 1987-2003. A population based study].
  • OBJECTIVE: Anal cancer is a rare disease.
  • The aim of this study was to describe anal cancer in Iceland in 1987-2003 with respect to incidence, histologic type, treatment, recurrence rate and survival.
  • MATERIAL AND METHODS: This is a retrospective study in which all malignant anal tumours diagnosed in Iceland in the period 1987-2003 were reviewed with respect to patient outcome.
  • This is a nationwide, population-based study of malignant tumours of the anal region.
  • RESULTS: From 1987-2003 thirty-eight patients were diagnosed with anal cancer, 28 females and 10 males.
  • The average age at diagnosis was 63.4 years.
  • Age standardized incidence rates for anal cancer in Iceland were 0.3 (+/-0.2) of 100.000 males and 0.9 (+/-0.4) of 100.000 females.
  • The remaining histologic types were malignant melanoma (n=3), adenosquamous carcinoma (n=1), adenocarcinoma (n=1), GIST (n=1) and undifferentiated carcinoma (n=2).
  • The duration of symptoms before diagnosis ranged from 2 weeks to 96 months (mean value 3.5 months).
  • The mean value of the time from diagnosis of the primary to the recurrent cancer was 15.6 months (range, 5.9-117).
  • Sixteen patients remain with disease and ten have died of anal cancer.
  • CONCLUSION: Age-standardized incidence for anal cancer in Iceland is similar to other regions.
  • Average age at diagnosis, male-female ratio and prognosis is similar to reports in other studies.
  • The proportion of adenocarcinoma of the anus is lower in Iceland than elsewhere.
  • [MeSH-major] Anus Neoplasms / epidemiology
  • [MeSH-minor] Adenocarcinoma / epidemiology. Aged. Carcinoma / epidemiology. Carcinoma, Adenosquamous / epidemiology. Carcinoma, Squamous Cell / epidemiology. Defecation. Female. Gastrointestinal Hemorrhage / etiology. Humans. Iceland / epidemiology. Incidence. Male. Melanoma / epidemiology. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Pain / etiology. Pruritus / epidemiology. Retrospective Studies. Survival Analysis

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  • (PMID = 16741319.001).
  • [ISSN] 0023-7213
  • [Journal-full-title] Læknablađiđ
  • [ISO-abbreviation] Laeknabladid
  • [Language] ice
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Iceland
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17. Pedersen ME, Rahr HB, Fenger C, Qvist N: Adenocarcinoma arising from the rectal stump eleven years after excision of an ileal J-pouch in a patient with ulcerative colitis: report of a case. Dis Colon Rectum; 2008 Jul;51(7):1146-8
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  • [Title] Adenocarcinoma arising from the rectal stump eleven years after excision of an ileal J-pouch in a patient with ulcerative colitis: report of a case.
  • We report a case of adenocarcinoma in the anal canal 11 years after removal of a failed ileal J-pouch.
  • The anus had been left in place at the pouch excision because of severe fibrosis in the pelvis.
  • [MeSH-major] Adenocarcinoma, Mucinous / etiology. Colitis, Ulcerative / surgery. Colonic Pouches / pathology. Rectal Neoplasms / etiology
  • [MeSH-minor] Anastomosis, Surgical. Biopsy. Diagnosis, Differential. Fatal Outcome. Follow-Up Studies. Humans. Ileostomy. Male. Middle Aged. Proctocolectomy, Restorative / methods. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 18437493.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Kuroda N, Tanida N, Ohara M, Hirouchi T, Mizuno K, Kubo A, Lee GH: Anal canal adenocarcinoma with MUC5AC expression suggestive of anal gland origin. Med Mol Morphol; 2007 Mar;40(1):50-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal canal adenocarcinoma with MUC5AC expression suggestive of anal gland origin.
  • Anal canal adenocarcinomas arising in the anal ducts or glands are very rare neoplasms, and few useful immunohistochemical markers of these carcinomas are known to date.
  • A 57-year-old man presented with anal bleeding, difficulty of defecation, and anal pain.
  • Macroscopic findings of the surgically resected material showed circular stenosis of the anal canal.
  • Microscopically, the proliferation of adenocarcinoma cells with mucin production was observed in the submucosal and muscular layers.
  • Immunohistochemically, normal rectal-type mucosa and normal anal ducts/glands showed the patterns of cytokeratin 7 (CK7)(-)/CK19(+, focal)/MUC5AC(-) and CK7(+, diffuse)/CK19(+, diffuse)/MUC5AC(+, focal), respectively, and neoplastic cells showed the pattern of CK7(+, diffuse)/CK19(+, diffuse)/MUC5AC(+, focal).
  • Finally, our preliminary report suggests that the immunohistochemical combination of CK7, CK19, and MUC5AC may be an available marker for adenocarcinoma of anal ducts/glands origin.
  • [MeSH-major] Adenocarcinoma / pathology. Anal Canal / pathology. Anus Neoplasms / pathology. Mucins / metabolism

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  • [Cites] J Clin Pathol. 1996 Dec;49(12):1009-11 [9038740.001]
  • [Cites] Br J Surg. 1970 Jun;57(6):434-6 [4317275.001]
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  • (PMID = 17384991.001).
  • [ISSN] 1860-1480
  • [Journal-full-title] Medical molecular morphology
  • [ISO-abbreviation] Med Mol Morphol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucins
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19. Wakatsuki K, Oeda Y, Isono T, Yoshioka S, Nukui Y, Yamazaki K, Nabeshima S, Miyazaki M: Adenocarcinoma of the rectosigmoid colon seeding into pre-existing anal fistula. Hepatogastroenterology; 2008 May-Jun;55(84):952-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma of the rectosigmoid colon seeding into pre-existing anal fistula.
  • This paper reports a rare case of rectosigmoid colon carcinoma metastasizing to anal fistula.
  • The patient is a 57-year old man with a 7-year history of a fistula in ano.
  • Pathology revealed that the colon cancer and the perianal tumor were both moderately differentiated adenocarcinoma.
  • Sixteen reports could be found of implantation metastasis of colorectal cancer into anal fistula.
  • In diagnosis, it is important to differentiate implantation of colorectal cancer in anal fistula from primary anal fistular adenocarcinoma.
  • Furthermore, immunohistochemistry for cytokeratins 7 and 20 was performed on tissues to distinguish colorectal adenocarcinoma from anal gland carcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Anus Neoplasms / secondary. Neoplasm Seeding. Rectal Fistula / pathology. Rectal Neoplasms / pathology. Sigmoid Neoplasms / pathology
  • [MeSH-minor] Anal Canal / pathology. Anal Canal / surgery. Colon, Sigmoid / pathology. Colon, Sigmoid / surgery. Follow-Up Studies. Humans. Lymph Node Excision. Male. Middle Aged. Neoplasm Staging. Reoperation

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  • (PMID = 18705305.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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20. Gaertner WB, Hagerman GF, Goldberg SM, Finne CO 3rd: Perianal Paget's disease treated with wide excision and gluteal skin flap reconstruction: report of a case and review of the literature. Dis Colon Rectum; 2008 Dec;51(12):1842-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Paget's disease of the anus is a rare perianal disorder.
  • The condition is often associated with underlying invasive carcinoma and the prognosis is poor when underlying adenocarcinoma is present.
  • CONCLUSION: Perianal Paget's disease continues to pose problems in diagnosis and treatment.
  • [MeSH-major] Anus Neoplasms / surgery. Paget Disease, Extramammary / surgery. Surgical Flaps

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  • (PMID = 18584248.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 34
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21. Suenaga M, Oya M, Ueno M, Yamamoto J, Yamaguchi T, Mizunuma N, Hatake K, Kato Y, Muto T: Anal canal carcinoma with Pagetoid spread: report of a case. Surg Today; 2006;36(7):666-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal canal carcinoma with Pagetoid spread: report of a case.
  • A 70-year-old man with a history of colon polyps was found to have a semipedunculated polyp in the anal canal.
  • Histological examination of biopsy specimens revealed well-differentiated adenocarcinoma of the anal canal.
  • Pathological examination of the anal canal carcinoma revealed submucosally invasive well-differentiated adenocarcinoma with a positive distal surgical margin.
  • Pathological examination revealed continuance within the epidermis between the anal canal adenocarcinoma and Paget's cells in the perianal skin lesion.
  • Thus, we concluded that the perianal skin lesion was Pagetoid spread of anal canal adenocarcinoma.
  • This report shows that the perianal skin should be examined carefully in patients with anal canal carcinoma.
  • [MeSH-minor] Adenocarcinoma. Aged. Anal Canal / pathology. Anus Neoplasms. Humans. Male

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  • (PMID = 16794808.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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22. Kobayashi H, Ueno H, Hashiguchi Y, Ishiguro M, Omata J, Kajiwara Y, Shimazaki H, Mochizuki H: T1 neuroendocrine carcinoma of anal canal after transanal resection for intramucosal adenocarcinoma. Jpn J Clin Oncol; 2006 May;36(5):325-8
MedlinePlus Health Information. consumer health - Anal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] T1 neuroendocrine carcinoma of anal canal after transanal resection for intramucosal adenocarcinoma.
  • Neuroendocrine carcinomas of the anal canal are rare, representing 1% of malignant tumors of the anal canal.
  • We describe the case of a 63-year-old female with T1 neuroendocrine carcinoma of the anal canal arising from the site of a previous transanal excision performed 13 months earlier for intramucosal adenocarcinoma of the anal canal.
  • In this case, it is likely that the neuroendocrine tumor, which infiltrated into the submucosal layer with venous invasion, had developed over the intervening 13 months following the original transanal excision of the adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / surgery. Anal Canal / surgery. Anus Neoplasms / etiology. Carcinoma, Neuroendocrine / etiology. Neoplasm Recurrence, Local

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  • (PMID = 16702164.001).
  • [ISSN] 0368-2811
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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23. Fukumoto K, Suzuki S, Sakaguchi T, Morita Y, Oishi K, Suzuki A, Inaba K, Kamiya K, Miura K, Konno H: Adenocarcinoma arising from gastric duplication: a case report with literature review. Clin J Gastroenterol; 2008 Dec;1(4):148-152

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma arising from gastric duplication: a case report with literature review.
  • We report the case of a 50-year-old man with adenocarcinoma derived from gastric duplication.
  • Under the diagnosis of gastric duplication cysts, the oral cyst was removed with the gastric wall and the other cyst lesion firmly adhered to the bulbus was treated with distal gastrectomy.
  • Based on histological findings showing adenocarcinoma in the anal duplication cyst wall and regional lymph node metastases and cancer invasion into the duodenal stump, pancreatoduodenectomy was performed 9 days after the initial surgery.

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  • (PMID = 26193693.001).
  • [ISSN] 1865-7257
  • [Journal-full-title] Clinical journal of gastroenterology
  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Adenocarcinoma / Alimentary tract duplication / Cancer development / Gastric duplication cyst
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24. Itah R, Werbin N, Skornick Y, Greenberg R: [Anal mucinous adenocarcinoma arising in long standing fistula-in-ano]. Harefuah; 2008 Feb;147(2):117-9, 183
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Anal mucinous adenocarcinoma arising in long standing fistula-in-ano].
  • Perianal mucinous adenocarcinoma is an unusual but well described malignancy constituting approximately 3 to 11% of all anal carcinoma.
  • The pathology is thought to develop from one of three types, the distal part of the rectum, the mucin-secreting columnar epithelium of the anal glands, and from chronic fistula-in-ano.
  • The association of carcinoma with anal fistula may manifest itself in several ways: a fistula may be associated with cancer elsewhere in the colon; cancer may present as a fistula; or cancer may develop in anal fistula.
  • Mucinous adenocarcinoma of the anus supervening on a long-standing chronic anal fistula is an extremely rare disease with less then 150 cases reported in the literature, mainly single patient reports.
  • [MeSH-major] Adenocarcinoma, Mucinous / etiology. Anus Neoplasms / etiology. Rectal Fistula / complications

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  • (PMID = 18357666.001).
  • [ISSN] 0017-7768
  • [Journal-full-title] Harefuah
  • [ISO-abbreviation] Harefuah
  • [Language] heb
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Israel
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25. Okada K, Shatari T, Sasaki T, Tamada T, Suwa T, Furuuchi T, Takenaka Y, Hori M, Sakuma M: Is histopathological evidence really essential for making a surgical decision about mucinous carcinoma arising in a perianal fistula? Report of a case. Surg Today; 2008;38(6):555-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report an unusual case of mucinous adenocarcinoma of the anus associated with a chronic anal fistula, treated successfully by abdominoperineal resection (APR).
  • Conversely, the presence of mucin lakes and globules in specimens drained from the region of perianal sepsis may have been histologically informative for diagnosis.
  • Thus, although biopsy of the lesion is undoubtedly essential for diagnosis, it often fails to provide enough information to make a definite diagnosis of mucinous carcinoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / surgery. Anus Neoplasms / pathology. Anus Neoplasms / surgery. Rectal Fistula / complications

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  • (PMID = 18516539.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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26. Matsuo K, Hew KE, Im DD, Rosenshein NB: Clitoral metastasis of anal adenocarcinoma associated with rectovaginal fistula in long standing Crohn's disease. Eur J Obstet Gynecol Reprod Biol; 2009 Jun;144(2):182-3
MedlinePlus Health Information. consumer health - Vulvar Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clitoral metastasis of anal adenocarcinoma associated with rectovaginal fistula in long standing Crohn's disease.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Anus Neoplasms / pathology. Clitoris / pathology. Crohn Disease / complications. Rectovaginal Fistula / complications. Vulvar Neoplasms / secondary

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  • (PMID = 19406559.001).
  • [ISSN] 1872-7654
  • [Journal-full-title] European journal of obstetrics, gynecology, and reproductive biology
  • [ISO-abbreviation] Eur. J. Obstet. Gynecol. Reprod. Biol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Ireland
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27. Selvaggi F, Guadagni I, Pellino G, De Rosa M, Imbrogno G, Sciaudone G: Perianal Paget's disease happening with mucinous adenocarcinoma of the anal canal: managing rarities. J Cutan Pathol; 2010 Nov;37(11):1182-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Perianal Paget's disease happening with mucinous adenocarcinoma of the anal canal: managing rarities.
  • [MeSH-major] Adenocarcinoma, Mucinous / complications. Anal Canal / pathology. Anus Neoplasms / complications. Paget Disease, Extramammary / complications

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  • (PMID = 19702687.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Denmark
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28. Shintani F, Izumi M, Fujimura N: Neuroleptic malignant syndrome versus malignant disease: idiosyncratic or synchronous? Lancet; 2009 Jul 4;374(9683):90
Hazardous Substances Data Bank. LITHIUM CARBONATE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma / diagnosis. Anus Neoplasms / diagnosis. Neuroleptic Malignant Syndrome / diagnosis
  • [MeSH-minor] Antidepressive Agents / adverse effects. Antimanic Agents / adverse effects. Bipolar Disorder / complications. Bipolar Disorder / drug therapy. Causality. Colonoscopy. Creatine Kinase / blood. Creatine Kinase, MB Form / blood. Diagnosis, Differential. Fatal Outcome. Fever / etiology. Humans. Lithium Carbonate / adverse effects. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 19577697.001).
  • [ISSN] 1474-547X
  • [Journal-full-title] Lancet (London, England)
  • [ISO-abbreviation] Lancet
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antidepressive Agents; 0 / Antimanic Agents; 2BMD2GNA4V / Lithium Carbonate; EC 2.7.3.2 / Creatine Kinase; EC 2.7.3.2 / Creatine Kinase, MB Form
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