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1. Karachaliou N, Polyzos A, Kentepozidis N, Kakolyris S, Ziras N, Vardakis N, Kalykaki A, Milaki G, Georgoulias V, Androulakis N: A multicenter phase II trial with irinotecan plus oxaliplatin as first-line treatment for inoperable/metastatic cancer of the biliary tract. Oncology; 2010;78(5-6):356-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PATIENTS AND METHODS: Patients with histologically confirmed nonresectable biliary adenocarcinoma were treated with oxaliplatin (85 mg/m(2)) and irinotecan (200 mg/m(2)) every 3 weeks.
  • [MeSH-minor] Adult. Aged. Ampulla of Vater / pathology. Cholangiocarcinoma / drug therapy. Cholangiocarcinoma / pathology. Common Bile Duct Neoplasms / drug therapy. Common Bile Duct Neoplasms / pathology. Female. Gallbladder Neoplasms / drug therapy. Gallbladder Neoplasms / pathology. Humans. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Staging

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  • [Copyright] Copyright ©2010 S. Karger AG, Basel.
  • (PMID = 20798557.001).
  • [ISSN] 1423-0232
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Phytogenic; 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 7673326042 / irinotecan; XT3Z54Z28A / Camptothecin
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2. Ruemmele P, Dietmaier W, Terracciano L, Tornillo L, Bataille F, Kaiser A, Wuensch PH, Heinmoeller E, Homayounfar K, Luettges J, Kloeppel G, Sessa F, Edmonston TB, Schneider-Stock R, Klinkhammer-Schalke M, Pauer A, Schick S, Hofstaedter F, Baumhoer D, Hartmann A: Histopathologic features and microsatellite instability of cancers of the papilla of vater and their precursor lesions. Am J Surg Pathol; 2009 May;33(5):691-704
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histopathologic features and microsatellite instability of cancers of the papilla of vater and their precursor lesions.
  • The prevalence and development of microsatellite instability (MSI) and underlying mismatch repair (MMR) deficiency in the carcinogenesis of adenocarcinomas of the papilla of Vater and their precursor lesions are not well established.
  • We analyzed 120 ampullary adenomas (31 pure adenomas and 89 carcinoma-associated adenomas) and 170 pure adenocarcinomas for MSI, immunohistochemical expression of MMR proteins and specific histopathologic features.
  • The most common histologic subtype was intestinal (46.5%), followed by pancreatobiliary (23.5%), poorly differentiated adenocarcinomas (12.9%), intestinal-mucinous (8.2%), and invasive papillary carcinomas (5.3%).
  • The MMR deficient molecular pathway of carcinogenesis is associated with a histopathologic phenotype in ampullary cancer, similar to the one that has been well described in colon cancer.
  • [MeSH-major] Adenoma / pathology. Ampulla of Vater / pathology. Carcinoma / pathology. Common Bile Duct Neoplasms / pathology. DNA Mismatch Repair. Gene Expression Regulation, Neoplastic. Microsatellite Instability. Precancerous Conditions / pathology
  • [MeSH-minor] Adaptor Proteins, Signal Transducing / genetics. Adenocarcinoma / genetics. Adenocarcinoma / pathology. Adenocarcinoma, Mucinous / genetics. Adenocarcinoma, Mucinous / pathology. Adult. Aged. Aged, 80 and over. Carcinoma, Papillary / genetics. Carcinoma, Papillary / pathology. Cell Differentiation. DNA Methylation. DNA-Binding Proteins / genetics. Europe. Female. Gene Deletion. Genotype. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Male. Middle Aged. MutS Homolog 2 Protein / genetics. Neoplasm Invasiveness. Neoplasm Staging. Nuclear Proteins / genetics. Phenotype. Polymerase Chain Reaction. Promoter Regions, Genetic. Proportional Hazards Models. Risk Assessment. Treatment Outcome

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  • (PMID = 19252434.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein; 0 / MLH1 protein, human; 0 / Nuclear Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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3. Sakamoto H, Kitano M, Komaki T, Takeyama Y, Kudo M: Endoscopic ultrasound-guided pancreaticogastrostomy reconstruction. Endoscopy; 2007 Feb;39 Suppl 1:E70-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma, Mucinous / surgery. Ampulla of Vater / surgery. Anastomosis, Surgical. Common Bile Duct Neoplasms / surgery. Endosonography. Gastrostomy / methods. Pancreatectomy. Pancreatic Ducts / surgery. Postoperative Complications / therapy. Stents

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  • (PMID = 17354176.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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4. Higashi M, Goto M, Saitou M, Shimizu T, Rousseau K, Batra SK, Yonezawa S: Immunohistochemical study of mucin expression in periampullary adenomyoma. J Hepatobiliary Pancreat Sci; 2010 May;17(3):275-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND/PURPOSE: Benign tumors and tumor-like conditions in the ampullary area are uncommon, and there are extremely rare cases of adenomyoma (AM) and adenomyomatous hyperplasia (AMH).
  • RESULTS: For both types of lesions, epithelial glandular cells (EGCs) showed diffuse expression of MUC6 and focal expression of HIK1083, mainly in the inner region, and focal expression of MUC5AC, mainly at the surface.
  • CONCLUSIONS: A combined evaluation of IHC findings may be effective in the detection of AM and AMH, and also in distinguishing benign periampullary lesions, such as AM and AMH, from ampulla of Vater adenocarcinoma, thus avoiding excessive surgery.

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  • (PMID = 19784541.001).
  • [ISSN] 1868-6982
  • [Journal-full-title] Journal of hepato-biliary-pancreatic sciences
  • [ISO-abbreviation] J Hepatobiliary Pancreat Sci
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA078590; United States / NCI NIH HHS / CA / CA 78590
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / MUC4 protein, human; 0 / MUC5AC protein, human; 0 / MUC6 protein, human; 0 / Mucin 5AC; 0 / Mucin-4; 0 / Mucin-6; 0 / Mucins
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5. Bogoevski D, Chayeb H, Cataldegirmen G, Schurr PG, Kaifi JT, Mann O, Yekebas EF, Izbicki JR: Nodal microinvolvement in patients with carcinoma of the papilla of vater receiving no adjuvant chemotherapy. J Gastrointest Surg; 2008 Nov;12(11):1830-7; discussion 1837-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nodal microinvolvement in patients with carcinoma of the papilla of vater receiving no adjuvant chemotherapy.
  • BACKGROUND: To assess the prognostic significance of nodal microinvolvement in patients with carcinoma of the papilla of Vater.
  • The vast majority of patients were operated upon pancreatic ductal adenocarcinoma (n = 566, 73%), followed by carcinomas of the papilla of Vater (n = 112, 14%), pancreatic neuroendocrine carcinomas (n = 39, 5%), intraductal papillary mucinous neoplasms (n = 33, 4%), and distal bile duct carcinomas (n = 27, 3%).
  • Fresh-frozen tissue sections from 169 lymph nodes (LNs) classified as tumor free by routine histopathology from 57 patients with R0 resected carcinoma of the papilla of Vater who had been spared from adjuvant chemotherapy were immunohistochemically (IHC) examined, using a sensitive IHC assay with the anti-epithelial monoclonal antibody Ber-EP4 for tumor cell detection.
  • CONCLUSIONS: The influence of occult tumor cell dissemination in LNs of patients with histologically proven carcinoma of the papilla of Vater supports the need for further tumor staging through immunohistochemistry.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / surgery. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. Common Bile Duct Neoplasms / surgery. Lymph Nodes / pathology

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  • (PMID = 18791769.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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6. Itoi T, Tsuji S, Sofuni A, Itokawa F, Kurihara T, Tsuchiya T, Ishii K, Ikeuchi N, Igarashi M, Gotoda T, Moriyasu F: A novel approach emphasizing preoperative margin enhancement of tumor of the major duodenal papilla with narrow-band imaging in comparison to indigo carmine chromoendoscopy (with videos). Gastrointest Endosc; 2009 Jan;69(1):136-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • En bloc tissue revealed 13 adenomas and 1 adenoma with focal adenocarcinoma.
  • [MeSH-major] Adenoma / pathology. Ampulla of Vater / pathology. Diagnostic Imaging / methods. Duodenal Neoplasms / pathology. Duodenoscopy / methods. Image Enhancement / methods. Indigo Carmine

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  • (PMID = 19026411.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] D3741U8K7L / Indigo Carmine
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7. Yamashita Y, Ito K, Fujita N, Noda Y, Kobayashi G, Obana T, Horaguchi J, Kato Y, Koshita S, Kanno Y, Ogawa T, Kurose A, Sawai T: A case of early carcinoma of the papilla of Vater confined to the mucosa and continuative epithelium of glands in Oddi's sphincter (m-God) treated by endoscopic papillectomy. Intern Med; 2010;49(22):2447-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of early carcinoma of the papilla of Vater confined to the mucosa and continuative epithelium of glands in Oddi's sphincter (m-God) treated by endoscopic papillectomy.
  • We herein report a case of early stage ampullary cancer, treated by endoscopic papillectomy, in which tumor extension was confined to the mucosa and adjacent epithelium of the glands in Oddi's sphincter.
  • A 77-year-old man underwent screening esophagogastroduodenoscopy, which revealed a mass in the papilla of Vater, which was well-differentiated adenocarcinoma as proven by biopsy.
  • Histological examination showed adenocarcinoma limited to the mucosa of the common channel and continuative epithelium of the neighboring glands in Oddi's sphincter.
  • [MeSH-major] Ampulla of Vater. Carcinoma / surgery. Common Bile Duct Neoplasms / surgery. Duodenoscopy

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  • (PMID = 21088347.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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8. Jayaprakash N, O'Kelly F, Lim KT, Reynolds JV: Management of synchronous adenocarcinoma of the esophago-gastric junction and ampulla of Vater: case report of a surgically challenging condition. Patient Saf Surg; 2009;3(1):23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of synchronous adenocarcinoma of the esophago-gastric junction and ampulla of Vater: case report of a surgically challenging condition.
  • We report herein a case of a synchronous presentation of an adenocarcinoma of esophagago-gastric junction type II and an ampullary tumor that was treated by combined Whipple's pancreaticoduodenectomy, total gastrectomy and esophagectomy.

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  • (PMID = 19785744.001).
  • [ISSN] 1754-9493
  • [Journal-full-title] Patient safety in surgery
  • [ISO-abbreviation] Patient Saf Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2760510
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9. Huang SS, Jan YJ, Cheng SB, Yeh DC, Wu CC, Liu TJ, P'eng FK: Large cell neuroendocrine carcinoma of the ampulla of vater: Report of a case. Surg Today; 2006;36(11):1032-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Large cell neuroendocrine carcinoma of the ampulla of vater: Report of a case.
  • Large cell neuroendocrine carcinoma in the ampulla of Vater is rare and very different from the common ampullary adenocarcinoma.
  • Gastroendoscopy showed a swollen ampulla of Vater and pathological examination of an ampullary biopsy revealed findings of a carcinoid tumor.
  • [MeSH-major] Ampulla of Vater. Carcinoma, Large Cell / pathology. Carcinoma, Neuroendocrine / pathology. Common Bile Duct Neoplasms / pathology

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  • (PMID = 17072731.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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10. Hamada Y, Nakayama Y, Mizoguchi M, Ikeda S, Kuroki M, Iwasaki H: MK-1 expression in carcinoma of the ampulla of Vater as a predictor of improved prognosis after surgical resection. Cancer Lett; 2006 Nov 18;243(2):211-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MK-1 expression in carcinoma of the ampulla of Vater as a predictor of improved prognosis after surgical resection.
  • This retrospective study investigated the prognostic significance of MK-1 expression in human carcinoma of the ampulla of Vater (CAV).
  • Thirteen of 15 well-differentiated but only two of eight poorly differentiated adenocarcinoma were positive (P=0.0352).
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adult. Aged. Aged, 80 and over. Ampulla of Vater. Carcinoma, Papillary / metabolism. Carcinoma, Papillary / pathology. Carcinoma, Papillary / surgery. Carcinoma, Small Cell / metabolism. Carcinoma, Small Cell / pathology. Carcinoma, Small Cell / surgery. Female. Humans. Immunohistochemistry / statistics & numerical data. Kaplan-Meier Estimate. Male. Middle Aged. Multivariate Analysis. Prognosis. Proportional Hazards Models

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  • (PMID = 16616808.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Cell Adhesion Molecules; 0 / EPCAM protein, human
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11. Lowe MC, Coban I, Adsay NV, Sarmiento JM, Chu CK, Staley CA, Galloway JR, Kooby DA: Important prognostic factors in adenocarcinoma of the ampulla of Vater. Am Surg; 2009 Sep;75(9):754-60; discussion 761
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Important prognostic factors in adenocarcinoma of the ampulla of Vater.
  • Ampullary adenocarcinoma (AmpCA) carries a better overall survival (OS) rate than other periampullary cancers.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater. Common Bile Duct Neoplasms / pathology. Pancreaticoduodenectomy / methods

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  • (PMID = 19774945.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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12. Park I, Lee JL, Ryu MH, Kim TW, Chang HM, Lee SS, Sohn BS, Kim EK, Park DH, Lee SS, Suh DW, Lee SK, Kim MH, Lee J: Efficacy and safety of S-1 monotherapy in patients with advanced biliary tract adenocarcinoma: retrospective analysis of 162 patients. Oncology; 2009;76(2):126-32
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  • [Title] Efficacy and safety of S-1 monotherapy in patients with advanced biliary tract adenocarcinoma: retrospective analysis of 162 patients.
  • AIM: We investigated the efficacy and safety of S-1 monotherapy for the treatment of advanced biliary tract adenocarcinoma (BTA) in a clinical practice setting.
  • The primary tumors were intrahepatic (n = 57), in the gall bladder (n = 50), in extrahepatic bile ducts (n = 41) and in the ampulla of Vater (n = 14).
  • Response rates and survival differed significantly according to the primary site of the tumor (p = 0.002 and p < 0.001, respectively), with extrahepatic bile duct adenocarcinoma having the best prognosis.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Biliary Tract Neoplasms / drug therapy. Oxonic Acid / therapeutic use. Tegafur / therapeutic use

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  • (PMID = 19158445.001).
  • [ISSN] 1423-0232
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid
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13. Weng JM, Wu WQ, Liu QY: [Hepatoid adenocarcinoma of duodenal papilla: report of a case]. Zhonghua Bing Li Xue Za Zhi; 2009 Jul;38(7):494
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  • [Title] [Hepatoid adenocarcinoma of duodenal papilla: report of a case].
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Hepatocellular / pathology. Duodenal Neoplasms / pathology
  • [MeSH-minor] Aged. Ampulla of Vater / pathology. Carcinoid Tumor / pathology. Diagnosis, Differential. Endodermal Sinus Tumor / pathology. Humans. Male. alpha-Fetoproteins / metabolism

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  • (PMID = 19781206.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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14. Liu SH, Tsay SH: Coexistence of large cell neuroendocrine carcinoma and adenocarcinoma of the ampulla of vater. J Chin Med Assoc; 2008 Oct;71(10):536-40
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  • [Title] Coexistence of large cell neuroendocrine carcinoma and adenocarcinoma of the ampulla of vater.
  • We report a case of coexisting poorly differentiated endocrine carcinoma and conventional adenocarcinoma in the ampulla of Vater.
  • An initial endoscopic biopsy of the ampulla of Vater showed a poorly differentiated endocrine carcinoma in the lamina propria of duodenal mucosa.
  • After thorough microscopic examination of the ampulla of Vater, we incidentally found another conventional adenocarcinoma on the inner side of the duodenal papilla, and the tumor collided with the aforementioned carcinoma.
  • The association of neuroendocrine tumor and adenocarcinoma has been reported in a few case reports and a small series.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater / pathology. Carcinoma, Large Cell / pathology. Common Bile Duct Neoplasms / pathology. Neuroendocrine Tumors / pathology

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  • (PMID = 18955190.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China (Republic : 1949- )
  • [Number-of-references] 16
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15. Spyropoulou D, Vassiliou V, Tzelepi V, Kardari M, Tsamandas AC, Kardamakis D: Metastatic adenocarcinoma of parotid gland originating from the ampulla of vater: case report and review of the literature. J Gastrointest Cancer; 2007;38(2-4):95-8
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  • [Title] Metastatic adenocarcinoma of parotid gland originating from the ampulla of vater: case report and review of the literature.
  • AIM: To report a rare case of metastasis from an adenocarcinoma of the ampulla of Vater to the parotid gland.
  • PATIENTS AND METHODS: In February 2004, a 61-year-old male underwent Whipple surgery due to a grade II adenocarcinoma of the ampulla of Vater (stage IB:pT2N0M0).
  • Two months after chemotherapy (April 2007), the patient complained of a painless lump in the parotid region that was progressing fast.
  • Fine needle aspiration showed that the infiltrating mass was due to an adenocarcinoma of the ampulla of Vater.
  • CONCLUSIONS: Metastasis of adenocarcinoma of the ampulla of Vater to the parotid gland has not to our knowledge been previously reported.
  • [MeSH-major] Adenocarcinoma / secondary. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. Parotid Neoplasms / secondary

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  • (PMID = 19016351.001).
  • [ISSN] 1941-6628
  • [Journal-full-title] Journal of gastrointestinal cancer
  • [ISO-abbreviation] J Gastrointest Cancer
  • [Language] eng
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16. Kitami CE, Kurosaki I, Koyama Y, Makino H, Hatakeyama K: Long-term survival after hepatectomy for hepatic recurrence of carcinoma of the papilla of Vater. J Hepatobiliary Pancreat Surg; 2005;12(4):321-3
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  • [Title] Long-term survival after hepatectomy for hepatic recurrence of carcinoma of the papilla of Vater.
  • We present herein a rare case of a long-term survivor after major hepatectomy performed for a metastatic liver tumor from carcinoma of the papilla of Vater.
  • A 74-year-old man had undergone a pancreaticoduodenectomy for carcinoma of the papilla of Vater with obstructive jaundice, in April 1995.
  • Histologically, an exposed mass-forming type of tumor, measuring 40 x 30 mm, was composed of mucinous and papillary adenocarcinoma, invading into the muscularis propria of the duodenum, without lymph node metastases.
  • Hepatectomy for hepatic metastases from carcinoma of the papilla of Vater is thought to be a useful surgical treatment in selected patients.
  • [MeSH-major] Adenocarcinoma, Mucinous / surgery. Adenocarcinoma, Papillary / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / pathology. Hepatectomy. Liver Neoplasms / secondary. Liver Neoplasms / surgery

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  • (PMID = 16133701.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; 1-UFT protocol
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17. Ohike N, Coban I, Kim GE, Basturk O, Tajiri T, Krasinskas A, Bandyopadhyay S, Morohoshi T, Shimada Y, Kooby DA, Staley CA, Goodman M, Adsay NV: Tumor budding as a strong prognostic indicator in invasive ampullary adenocarcinomas. Am J Surg Pathol; 2010 Oct;34(10):1417-24
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  • [Title] Tumor budding as a strong prognostic indicator in invasive ampullary adenocarcinomas.
  • Prognostication of invasive ampullary adenocarcinomas (AACs) and their stratification into appropriate management categories have been highly challenging owing to a lack of well-established predictive parameters.
  • In colorectal cancers, recent studies have shown that tumor budding confers a worse prognosis and correlates significantly with nodal metastasis and recurrence; however, this has not been evaluated in AAC.To investigate the prevalence, significance, and clinical correlations of tumor budding in AAC, 244 surgically resected, stringently defined, invasive AAC were analyzed for tumor budding---defined as the presence of more than or equal to 5 isolated single cancer cells or clusters composed of fewer than 5 cancer cells per field measuring 0.785 mm using a 20× objective lens in the stroma of the invasive front.

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  • [ErratumIn] Am J Surg Pathol. 2010 Dec;34(12):1892. Volkan Adsay, Nazmi [corrected to Adsay, N. Volkan]
  • (PMID = 20871215.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA062924; United States / NCI NIH HHS / CA / CA088273-01; United States / NCI NIH HHS / CA / P50 CA062924-18; United States / NCI NIH HHS / CA / P20 CA101936; United States / NCI NIH HHS / CA / R03 CA088273; United States / NCI NIH HHS / CA / CA101936; United States / NCI NIH HHS / CA / R03 CA088273-01
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS315768; NLM/ PMC3163902
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18. Lee JH, Lee KG, Ryou H, Jun YJ, Paik SS, Park HK, Lee KS: Significance analysis of histologic type and perineural invasion as prognostic factors after curative resection of ampulla of Vater carcinoma. Hepatogastroenterology; 2010 May-Jun;57(99-100):646-52
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  • [Title] Significance analysis of histologic type and perineural invasion as prognostic factors after curative resection of ampulla of Vater carcinoma.
  • BACKGROUND/AIMS: Periampullary adenocarcinoma has either intestinal- or pancreatobiliary-type of differentiation.
  • The influences of histologic type and perineural invasion on recurrence and survival in ampullar of Vater carcinoma still need to be assessed.
  • METHODOLOGY: We reviewed and analyzed the clinicopathologic data, surgical outcomes, recurrence and survival of 49 patients who received curative pancreatoduodenectomy for ampulla of Vater carcinoma at Hanyang University Hospital between July 1994 and June 2008.
  • [MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. Peripheral Nerves / pathology

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  • (PMID = 20698243.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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19. Schönleben F, Qiu W, Allendorf JD, Chabot JA, Remotti HE, Su GH: Molecular analysis of PIK3CA, BRAF, and RAS oncogenes in periampullary and ampullary adenomas and carcinomas. J Gastrointest Surg; 2009 Aug;13(8):1510-6
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  • [Title] Molecular analysis of PIK3CA, BRAF, and RAS oncogenes in periampullary and ampullary adenomas and carcinomas.
  • BACKGROUND: Mutations of KRAS are known to occur in periampullary and ampullary adenomas and carcinomas.
  • While oncogenic BRAF contributes to the tumorigenesis of both pancreatic ductal adenocarcinoma and intraductal papillary mucinous neoplasms/carcinomas (IPMN/IPMC), PIK3CA mutations were only detected in IPMN/IPMC.
  • This study aimed to elucidate possible roles of BRAF and PIK3CA in the development of ampullary and periampullary adenomas and carcinomas.
  • METHODS: Mutations of BRAF, NRAS, HRAS, KRAS, and PIK3CA were evaluated in seven adenomas, seven adenomas with carcinoma in situ, and 21 adenocarcinomas of the periampullary duodenal region and the ampulla of Vater.
  • CONCLUSION: Our data provide evidence that oncogenic properties of KRAS and BRAF but not NRAS, HRAS, and PIK3CA contribute to the tumorigenesis of periampullary and ampullary tumors; BRAF mutations occur more frequently in periampullary than ampullary neoplasms.

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  • (PMID = 19440799.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA109525-05; United States / NCI NIH HHS / CA / R21 CA127701; United States / NCI NIH HHS / CA / CA127701-01A2; United States / NCI NIH HHS / CA / R01CA109525; United States / NCI NIH HHS / CA / R01 CA109525; United States / NCI NIH HHS / CA / CA109525-05; United States / NCI NIH HHS / CA / R21 CA127701-01A2; United States / NCI NIH HHS / CA / R21CA127701
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / KRAS protein, human; 0 / Proto-Oncogene Proteins; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.137 / PIK3CA protein, human; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / ras Proteins
  • [Other-IDs] NLM/ NIHMS164917; NLM/ PMC3915027
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20. Shin JA, An M, Choi JI, Kim SH, Lee WJ, Park SJ, Park JW, Hong EK: [A case of hepatectomy for liver metastasis after pancreatoduodenectomy for carcinoma of ampulla of Vater]. Korean J Gastroenterol; 2006 Dec;48(6):434-7
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  • [Title] [A case of hepatectomy for liver metastasis after pancreatoduodenectomy for carcinoma of ampulla of Vater].
  • After curative resection of carcinoma of ampulla of Vater, 5-year survival rate has been reported ranging from 40% to 60%.
  • There have been few reports on long-term survivors after hepatectomy for metastatic liver tumors from carcinoma of ampulla of Vater.
  • We report a 42 year-old female patient with solitary hepatic metastasis from carcinoma of ampulla of Vater, which was successfully treated by hepatectomy 69 months after curative Whipple's operation.
  • Histologic examination of the resected specimen had revealed stage IB moderately-differentiated, intestinal type adenocarcinoma (T2N0M0).
  • Histologic study confirmed the presence of metastatic liver tumor from carcinoma of ampulla of Vater.
  • [MeSH-major] Ampulla of Vater. Carcinoma / diagnosis. Carcinoma / surgery. Common Bile Duct Neoplasms / pathology. Hepatectomy. Liver Neoplasms / diagnosis. Liver Neoplasms / surgery

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  • (PMID = 17189929.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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21. Nakano H, Asakura T, Koizumi S, Asano T, Watanabe T, Otsubo T, Takizawa K: Second surgery after a pancreaticoduodenectomy in patients with periampullary malignancies. Hepatogastroenterology; 2008 Mar-Apr;55(82-83):687-91
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  • RESULTS: One patient with lower bile duct adenocarcinoma underwent a remnant splenopancreatectomy due to pancreatic recurrence 36 months after pancreaticoduodenectomy.
  • The other patient with lower bile duct adenocarcinoma underwent a hepatectomy due to a solitary liver metastasis 47 months after a pancreaticoduodenectomy.
  • CONCLUSIONS: The present study reports 2 rare cases with lower bile duct adenocarcinoma in which a recurrent tumor was removed after pancreaticoduodenectomy.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Pancreaticoduodenectomy

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  • (PMID = 18613434.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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22. Santini D, Vincenzi B, Tonini G, Scarpa S, Vasaturo F, Malacrino C, Vecchio F, Borzomati D, Valeri S, Coppola R, Magistrelli P, Nuzzo G, Picciocchi A: Cyclooxygenase-2 overexpression is associated with a poor outcome in resected ampullary cancer patients. Clin Cancer Res; 2005 May 15;11(10):3784-9
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  • [Title] Cyclooxygenase-2 overexpression is associated with a poor outcome in resected ampullary cancer patients.
  • PURPOSE: To identify potential prognostic molecular factors in ampullary adenocarcinoma that could be of significant importance.
  • To this end, we examined the possible prognostic significance of cyclooxygenase-2 (Cox-2) and Survivin expression and the apoptotic index in a cohort of uniformly treated patients with ampullary cancer treated with radical surgical excision.
  • EXPERIMENTAL DESIGN: The entry criteria were that the patients have a pathologic diagnosis of ampullary cancer which had been resected.
  • RESULTS: Thirty-nine tumor specimens from resected ampullary adenocarcinoma patients were included.
  • CONCLUSIONS: The results of the present article provide, for the first time, evidence that Cox-2 expression, but not Survivin expression, may represent a significant prognostic factor after surgical resection in patients affected by cancer of the ampulla of Vater.
  • Further studies are required to determine whether Cox-2 inhibitors may be useful for the therapy or prevention of ampullary carcinoma.
  • [MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / genetics. Common Bile Duct Neoplasms / pathology. Gene Expression Profiling. Prostaglandin-Endoperoxide Synthases / biosynthesis. Prostaglandin-Endoperoxide Synthases / genetics

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  • (PMID = 15897577.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Membrane Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases
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23. He KJ, Jiao XY, Yang XW, Hu YZ: [Risk factors of postoperative complications of pancreatoduodenectomy]. Ai Zheng; 2008 Jan;27(1):75-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / adverse effects. Postoperative Hemorrhage / etiology
  • [MeSH-minor] Adenocarcinoma / blood. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adult. Aged. Female. Gastrointestinal Hemorrhage / etiology. Humans. Male. Middle Aged. Neoplasm Invasiveness. Pancreatic Fistula / etiology. Proportional Hazards Models. Retrospective Studies. Risk Factors. Serum Albumin / metabolism. Survival Rate

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  • (PMID = 18184469.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Serum Albumin
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24. Winter JM, Cameron JL, Lillemoe KD, Campbell KA, Chang D, Riall TS, Coleman J, Sauter PK, Canto M, Hruban RH, Schulick RD, Choti MA, Yeo CJ: Periampullary and pancreatic incidentaloma: a single institution's experience with an increasingly common diagnosis. Ann Surg; 2006 May;243(5):673-80; discussion 680-3
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  • The 3 most common diagnoses in the PI group were IPMN without invasive cancer (30%), cystadenoma (17%), and pancreatic ductal adenocarcinoma (10%).
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / diagnosis. Pancreatic Neoplasms / diagnosis


25. Hustinx SR, Fukushima N, Zahurak ML, Riall TS, Maitra A, Brosens L, Cameron JL, Yeo CJ, Offerhaus GJ, Hruban RH, Goggins M: Expression and prognostic significance of 14-3-3sigma and ERM family protein expression in periampullary neoplasms. Cancer Biol Ther; 2005 May;4(5):596-601
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  • The 5' region of 14-3-3sigma (stratifin) is hypomethylated in pancreatic adenocarcinomas and is associated with gene overexpression.
  • We investigated the prognostic significance of aberrant expression of 14-3-3sigma and the ERM proteins (Ezrin, radixin, Moesin) in a series of invasive periampullary adenocarcinomas including 300 infiltrating pancreatic adenocarcinomas, 54 ampullary adenocarcinomas, and 33 noninvasive intraductal papillary mucinous neoplasms from patients who underwent pancreaticoduodenal resection at The Johns Hopkins Hospital, Baltimore, MD, between 1991 and 2003.
  • A similar proportion of ampullary cancers showed 14-3-3sigma and ERM protein expression.
  • Aberrant expression of 14-3-3sigma may contribute to the outcome of patients with pancreatic ductal adenocarcinoma.
  • [MeSH-major] Ampulla of Vater / metabolism. Biomarkers, Tumor / metabolism. Common Bile Duct Diseases / metabolism. DNA-Binding Proteins / metabolism. Exonucleases / metabolism. Neoplasm Proteins / metabolism. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / metabolism. Transcription Factors / metabolism
  • [MeSH-minor] 14-3-3 Proteins. Adenocarcinoma / metabolism. Adenocarcinoma, Mucinous / metabolism. Adult. Aged. Aged, 80 and over. Carcinoma, Pancreatic Ductal / metabolism. Exoribonucleases. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Male. Middle Aged. Multivariate Analysis. Prognosis. Retrospective Studies

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  • (PMID = 15908786.001).
  • [ISSN] 1538-4047
  • [Journal-full-title] Cancer biology & therapy
  • [ISO-abbreviation] Cancer Biol. Ther.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 14-3-3 Proteins; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / ETV5 protein, human; 0 / Neoplasm Proteins; 0 / Transcription Factors; EC 3.1.- / Exonucleases; EC 3.1.- / Exoribonucleases; EC 3.1.- / SFN protein, human
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26. Zhou J, Hsu CC, Winter JM, Pawlik TM, Laheru D, Hughes MA, Donehower R, Wolfgang C, Akbar U, Schulick R, Cameron J, Herman JM: Adjuvant chemoradiation versus surgery alone for adenocarcinoma of the ampulla of Vater. Radiother Oncol; 2009 Aug;92(2):244-8
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  • [Title] Adjuvant chemoradiation versus surgery alone for adenocarcinoma of the ampulla of Vater.
  • BACKGROUND AND PURPOSE: To examine the role of adjuvant chemoradiation (CRT) in patients with resected ampullary adenocarcinoma.
  • MATERIALS AND METHODS: The records of patients who underwent curative surgery for ampullary adenocarcinoma at a single institution between 1992 and 2007 were reviewed.
  • CONCLUSIONS: Adjuvant chemoradiation following curative resection for ampullary adenocarcinoma did not lead to a statistically significant benefit in overall survival.
  • [MeSH-major] Adenocarcinoma / therapy. Ampulla of Vater. Common Bile Duct Neoplasms / therapy

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  • (PMID = 19541379.001).
  • [ISSN] 1879-0887
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA006973
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Ireland
  • [Other-IDs] NLM/ NIHMS443631; NLM/ PMC3700350
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27. Manolakis AC, Kardasi M, Tsiopoulos FD, Kapsoritakis AN, Psychos AK, Potamianos SP: Progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome) with fatal outcome, after the manifestation of an ampullary adenocarcinoma. Pancreas; 2010 Jul;39(5):688-9
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  • [Title] Progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome) with fatal outcome, after the manifestation of an ampullary adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Ampulla of Vater. Common Bile Duct Neoplasms / diagnosis. Supranuclear Palsy, Progressive / etiology

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  • (PMID = 20562584.001).
  • [ISSN] 1536-4828
  • [Journal-full-title] Pancreas
  • [ISO-abbreviation] Pancreas
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antiparkinson Agents; 0 / Indoles; 030PYR8953 / ropinirole; 46627O600J / Levodopa; BF4C9Z1J53 / Amantadine
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28. Bae JM, Kim SW, Kim SW, Song SK: [Metachronous four primary malignancies in gastro-intestinal tract]. Korean J Gastroenterol; 2009 Jun;53(6):373-7
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  • Recently, we experienced a 70 year-old male who was diagnosed with metachronous four primary malignancies in rectum, ascending colon, stomach, and ampulla of Vater.
  • [MeSH-major] Adenocarcinoma / diagnosis. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / diagnosis. Gastrointestinal Neoplasms / diagnosis. Neoplasms, Second Primary / diagnosis
  • [MeSH-minor] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / surgery. Aged. Colonic Neoplasms / diagnosis. Colonic Neoplasms / surgery. Humans. Male. Rectal Neoplasms / diagnosis. Rectal Neoplasms / surgery. Stomach Neoplasms / diagnosis. Stomach Neoplasms / pathology. Stomach Neoplasms / surgery. Tomography, X-Ray Computed

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  • (PMID = 19556845.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
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29. Vermeil V, D'Amore L, Ceci F, Dassatti MR, Negro A, Gossetti F, Negro P: [Familial polyposis coli associated with carcinoma of the uterine cervix]. Chir Ital; 2008 May-Jun;60(3):355-9
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  • Familial polyposis coli is a heterogeneous disease with a broad spectrum of clinical manifestations including not only multiple polyposis of the small bowel, but also multiple primary tumours, such as carcinoma of the ampulla of Vater, subcutaneous tumours, bone tumours, central nervous system tumous and gynaecological malignancies.
  • Polyposis coli was identified late in the second patient who showed an evolution towards colonic adenocarcinoma with multiple hepatic metastases.


30. Kim YK, Han YM, Kim CS: Usefulness of fat-suppressed T1-weighted MRI using orally administered superparamagnetic iron oxide for revealing ampullary carcinomas. J Comput Assist Tomogr; 2007 Jul-Aug;31(4):519-25
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  • [Title] Usefulness of fat-suppressed T1-weighted MRI using orally administered superparamagnetic iron oxide for revealing ampullary carcinomas.
  • OBJECTIVE: To evaluate the value of adding fat-suppressed (FS) T1-weighted magnetic resonance imaging (MRI) with orally administered superparamagnetic iron oxide (SPIO) to the 3-dimensional dynamic MRI for revealing ampullary carcinomas.
  • MATERIALS: Twenty-five patients with ampullary carcinoma who underwent MRI with orally administered SPIO, including a FS T1-weighted fast low-angle shot (FLASH) sequence, a respiratory-triggered turbo spin-echo (RT-TSE) sequence, and the 3-phasic 3-dimensional dynamic images, were enrolled in this study.
  • CONCLUSIONS: Addition of the FS FLASH image using orally administered SPIO to the dynamic MRI is useful for revealing ampullary carcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Ampulla of Vater. Common Bile Duct Neoplasms / diagnosis. Contrast Media. Ferric Compounds. Image Enhancement / methods. Magnetic Resonance Imaging / methods

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  • (PMID = 17882025.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Ferric Compounds; 1K09F3G675 / ferric oxide
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31. de Castro SM, Houwert JT, Lagarde SM, Reitsma JB, Busch OR, van Gulik TM, Obertop H, Gouma DJ: Evaluation of POSSUM for patients undergoing pancreatoduodenectomy. World J Surg; 2009 Jul;33(7):1481-7
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  • In multivariate analysis, one statistically significant factor associated with morbidity and not incorporated in POSSUM (P < 0.05) was identified: ampulla of Vater adenocarcinoma (OR = 1.73, 95% CI: 1.07-2.80).

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  • (PMID = 19384458.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2691933
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32. Artifon EL, Rodrigues AZ, Marques S, Halwan B, Sakai P, Bresciani C, Kumar A: Laparoscopic deployment of biliary self-expandable metal stent (SEMS) for one-step palliation in 23 patients with advanced pancreatico-biliary tumors--a pilot trial. J Gastrointest Surg; 2007 Dec;11(12):1686-91
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  • RESULTS: Indications for stent deployment were unresectable pancreatic cancer in 18, cholangiocarcinoma in two, neuroendocrine tumor in one and ampullary adenocarcinoma in two patients.
  • [MeSH-major] Adenocarcinoma / surgery. Biliary Tract Neoplasms / surgery. Palliative Care. Pancreatic Neoplasms / surgery. Stents

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  • (PMID = 17906909.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Suzuki S, Tanaka S, Hayashi T, Harada N, Suzuki M, Hanyu F, Ban S: Small-cell neuroendocrine carcinoma of the ampulla of Vater. J Hepatobiliary Pancreat Surg; 2006;13(5):450-3
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  • [Title] Small-cell neuroendocrine carcinoma of the ampulla of Vater.
  • We report a patient (an 80-year-old woman) with anemia and fecal occult blood, who had an emergency operation for carcinoma of the cecum (well-differentiated adenocarcinoma without local lymph node metastasis).
  • Postoperative magnetic resonance cholangiopancreatography, cholangiography, and upper gastroduodenal endoscopy showed a tumor of the ampulla of Vater, and pylorus-preserving pancreatoduodenectomy was performed.
  • As the histology of the tumor was distinct from cecal carcinoma, and no tumors were found in other organs, the tumor was diagnosed as primary small-cell neuroendocrine carcinoma of the ampulla of Vater.
  • The patient died due to multiple liver metastases of the carcinoma of the ampulla of Vater 7 months after the pancreatoduodenectomy.
  • [MeSH-major] Ampulla of Vater. Carcinoma, Neuroendocrine / pathology. Carcinoma, Small Cell / pathology. Common Bile Duct Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Aged, 80 and over. Cecal Neoplasms / pathology. Female. Humans. Neoplasms, Multiple Primary. Pancreaticoduodenectomy

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  • (PMID = 17013721.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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34. Kennedy EP, Yeo CJ: Pancreaticoduodenectomy with extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma. Surg Oncol Clin N Am; 2007 Jan;16(1):157-76
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  • [Title] Pancreaticoduodenectomy with extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Lymph Node Excision / methods. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Adenocarcinoma / mortality. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Gastrectomy. Humans. Lymph Nodes / anatomy & histology. Lymphatic Metastasis. Retroperitoneal Space. Survival Analysis


35. Sun JH, Chao M, Zhang SZ, Zhang GQ, Li B, Wu JJ: Coexistence of small cell neuroendocrine carcinoma and villous adenoma in the ampulla of Vater. World J Gastroenterol; 2008 Aug 7;14(29):4709-12
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  • [Title] Coexistence of small cell neuroendocrine carcinoma and villous adenoma in the ampulla of Vater.
  • Small cell neuroendocrine carcinoma of the ampulla of Vater is extremely rare and different from the common ampullary adenocarcinoma.
  • The ampullary adenoma is also a rare neoplasm and has the potential to develop an adenocarcinoma.
  • We herein describe an unusual case of a small cell neuroendocrine carcinoma associated with a villous adenoma in the ampulla of Vater with emphasis on computed tomography (CT) and histopathological findings.
  • [MeSH-major] Adenoma, Villous / complications. Ampulla of Vater. Carcinoma, Neuroendocrine / complications. Common Bile Duct Neoplasms / complications

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  • (PMID = 18698690.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2738800
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36. Carter JT, Grenert JP, Rubenstein L, Stewart L, Way LW: Tumors of the ampulla of vater: histopathologic classification and predictors of survival. J Am Coll Surg; 2008 Aug;207(2):210-8
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  • [Title] Tumors of the ampulla of vater: histopathologic classification and predictors of survival.
  • BACKGROUND: The histology and clinical behavior of ampullary tumors vary substantially.
  • We speculated that this might reflect the presence of two kinds of ampullary adenocarcinoma: pancreaticobiliary and intestinal.
  • STUDY DESIGN: We analyzed patient demographics, presentation, survival (mean followup 44 months), and tumor histology for 157 consecutive ampullary tumors resected from 1989 to 2006.
  • Patients with pancreaticobiliary ampullary adenocarcinomas presented with jaundice more often than those with the intestinal kind (p = 0.01) and had worse survival.
  • CONCLUSIONS: In addition to other factors, tumor type (intestinal versus pancreaticobiliary) had a major effect on survival in patients with ampullary adenocarcinoma.
  • The current concept of ampullary adenocarcinoma as a unique entity, distinct from duodenal and pancreatic adenocarcinoma, might be wrong.
  • Intestinal ampullary adenocarcinomas behaved like their duodenal counterparts, but pancreaticobiliary ones were more aggressive and behaved like pancreatic adenocarcinomas.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology

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  • (PMID = 18656049.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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37. Relles D, Baek J, Witkiewicz A, Yeo CJ: Periampullary and duodenal neoplasms in neurofibromatosis type 1: two cases and an updated 20-year review of the literature yielding 76 cases. J Gastrointest Surg; 2010 Jun;14(6):1052-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tumor location was the duodenum (60%), ampulla (31%), pancreas (5%), or bile duct/gallbladder (4%).
  • Tumor type was reported as somatostatinoma (40%), GIST (34%), adenocarcinoma (8%), carcinoid (6%), neurofibroma (5%), schwannoma (4%), or gangliocytic paraganglioma (3%).
  • CONCLUSIONS: These results underscore the importance of a thorough evaluation for tumors in NF1 patients with gastrointestinal symptoms, as well as subsequent surgical management when findings suggest a tumor in the periampullary region, as resection remains the mainstay of treatment.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / diagnosis. Duodenal Neoplasms / diagnosis. Neurofibromatosis 1 / complications

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  • (PMID = 20300877.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 76
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38. Singh A, Singh T, Chaudhary A: Synchronous resection of solitary liver metastases with pancreaticoduodenectomy. JOP; 2010;11(5):434-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma / surgery. Liver Neoplasms / surgery. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Ampulla of Vater / pathology. Ampulla of Vater / surgery. Female. Hepatectomy / methods. Humans. Intraoperative Period. Male. Middle Aged. Retrospective Studies. Time Factors. Young Adult

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  • [CommentIn] JOP. 2011 Jan;12(1):68-9; author reply 71 [21206108.001]
  • (PMID = 20818110.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Italy
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39. Khaimook A, Borkird J, Alapach S: The first successful laparoscopic Whipple procedure at Hat Yai Hospital: surgical technique and a case report. J Med Assoc Thai; 2010 Sep;93(9):1098-102
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  • With the benefit of minimally invasive approach, many institutes attempt to do Whipple procedure laparoscopically.
  • The patient was a 40-year-old, Thai-Muslim female, with the diagnosis of ampullary carcinoma.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Laparoscopy / methods. Pancreaticoduodenectomy / methods

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  • (PMID = 20873085.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Thailand
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40. Neilan RE, Groce JR, Jalil S, Raju GS: White bile (with video). Gastrointest Endosc; 2007 Jul;66(1):180-1; discussion 181
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater. Bile. Common Bile Duct Neoplasms / pathology

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  • (PMID = 17591495.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. Kim ST, Lee J, Lee KT, Lee JK, Lee KH, Choi SH, Heo JS, Choi DW, Park SH, Park JO, Lim HY, Park YS, Kang WK: The efficacy of frontline platinum-based combination chemotherapy in advanced adenocarcinoma of the ampulla of Vater. Med Oncol; 2010 Dec;27(4):1149-54
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  • [Title] The efficacy of frontline platinum-based combination chemotherapy in advanced adenocarcinoma of the ampulla of Vater.
  • Adenocarcinoma arising from the ampulla of Vater is a rare neoplasm that accounts for only 0.2% of all gastrointestinal tract malignancies and has limited data regarding its frontline therapy.
  • We investigated the treatment outcomes in patients with advanced adenocarcinoma of the ampulla of Vater receiving frontline cisplatin-based combination chemotherapy.
  • We analyzed 29 patients with advanced adenocarcinoma of the ampulla of Vater who had been treated by frontline cisplatin-based combination chemotherapy between June 2003 and April 2008.
  • The cisplatin-based combination chemotherapy showed moderate activity and a favorable toxicity profile as a frontline treatment for patients with advanced adenocarcinoma of the ampulla of Vater.
  • [MeSH-major] Adenocarcinoma / drug therapy. Ampulla of Vater / drug effects. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Common Bile Duct Neoplasms / drug therapy

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  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; B76N6SBZ8R / gemcitabine; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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42. Filiz G, Yerci O, Adim SB, Gurel S, Dolar E, Memik F: Periampullary carcinomas. Hepatogastroenterology; 2007 Jun;54(76):1247-9
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  • Histopathologic examinations of these tumors revealed adenocarcinoma in 15, small cell (neuroendocrin) carcinoma in two.
  • [MeSH-major] Ampulla of Vater / surgery. Carcinoma / mortality. Carcinoma / surgery. Duodenal Neoplasms / mortality. Duodenal Neoplasms / surgery

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  • (PMID = 17629080.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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43. Coté GA, Brunt EM, Jonnalagadda SS: Familial adenomatous polyposis-associated ampullary adenoma: response to chemotherapy for concurrent metastatic adenocarcinoma. Clin Gastroenterol Hepatol; 2009 Jun;7(6):e28-9
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  • [Title] Familial adenomatous polyposis-associated ampullary adenoma: response to chemotherapy for concurrent metastatic adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / prevention & control. Adenoma / drug therapy. Adenomatous Polyposis Coli / complications. Adenomatous Polyposis Coli / drug therapy. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / drug therapy. Drug Therapy

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  • (PMID = 19245848.001).
  • [ISSN] 1542-7714
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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44. Lai R, Freeman ML: Endoscopic ultrasound-guided bile duct access for rendezvous ERCP drainage in the setting of intradiverticular papilla. Endoscopy; 2005 May;37(5):487-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Ampulla of Vater / surgery. Common Bile Duct Diseases / surgery. Diverticulum / surgery. Drainage / methods. Endosonography
  • [MeSH-minor] Adenocarcinoma / surgery. Aged. Aged, 80 and over. Cholangiopancreatography, Endoscopic Retrograde. Female. Humans. Pancreatic Neoplasms / surgery. Sphincterotomy, Endoscopic / methods. Stents

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  • (PMID = 15844030.001).
  • [ISSN] 0013-726X
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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45. Alibegov RA, Prokhorenko TI, Sergeev OA, Khlusov AN: [The long term results and survival prognostic factors of surgical treatment ampulla Vateri cancer]. Khirurgiia (Mosk); 2008;(4):27-30
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  • [Title] [The long term results and survival prognostic factors of surgical treatment ampulla Vateri cancer].
  • Results of radical operative treatment of 21 patients with ampulla Vateri cancer are presented.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / mortality. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy / methods

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  • (PMID = 18454104.001).
  • [ISSN] 0023-1207
  • [Journal-full-title] Khirurgiia
  • [ISO-abbreviation] Khirurgiia (Mosk)
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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46. Henson DE, Schwartz AM, Nsouli H, Albores-Saavedra J: Carcinomas of the pancreas, gallbladder, extrahepatic bile ducts, and ampulla of vater share a field for carcinogenesis: a population-based study. Arch Pathol Lab Med; 2009 Jan;133(1):67-71
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  • [Title] Carcinomas of the pancreas, gallbladder, extrahepatic bile ducts, and ampulla of vater share a field for carcinogenesis: a population-based study.
  • CONTEXT: Carcinomas co-occur in the pancreas, extrahepatic bile ducts, and ampulla of Vater.
  • OBJECTIVE: To determine whether a field effect for carcinogenesis exists in the ampulla of Vater, extrahepatic bile ducts, gallbladder, and pancreas.
  • RESULTS: Incidence rates were 11.71, 1.43, 0.88, and 0.49 per 100,000 persons at risk for pancreatic, gallbladder, extrahepatic bile ducts, and ampullary carcinomas, respectively.
  • CONCLUSIONS: Carcinomas of the pancreas, gallbladder, extrahepatic bile ducts, and ampulla have a common embryonic cellular ancestry, differentiation pathways, mucosal histologic patterns, and population-related tumor development indicating a field effect in carcinogenesis.
  • Pancreatic cancers are most common because the surface area of the pancreas' ductal system is greater than that of the gallbladder, extrahepatic bile ducts, and ampulla.
  • [MeSH-major] Adenocarcinoma / pathology. Bile Duct Neoplasms / pathology. Common Bile Duct Neoplasms / pathology. Gallbladder Neoplasms / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Aged. Ampulla of Vater / pathology. Bile Ducts, Extrahepatic / pathology. Humans. Incidence. Neoplasms, Multiple Primary. Population Surveillance. United States / epidemiology

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  • [CommentIn] Arch Pathol Lab Med. 2009 Jun;133(6):850 [19492873.001]
  • (PMID = 19123739.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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47. Krishnan S, Rana V, Evans DB, Varadhachary G, Das P, Bhatia S, Delclos ME, Janjan NA, Wolff RA, Crane CH, Pisters PW: Role of adjuvant chemoradiation therapy in adenocarcinomas of the ampulla of vater. Int J Radiat Oncol Biol Phys; 2008 Mar 1;70(3):735-43
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  • [Title] Role of adjuvant chemoradiation therapy in adenocarcinomas of the ampulla of vater.
  • PURPOSE: The role of adjuvant chemoradiation therapy (CRT) in the treatment of ampullary cancers remains undefined.
  • METHODS AND MATERIALS: Between May 1990 and January 2006, 54 of 96 patients with ampullary adenocarcinoma who underwent potentially curative pancreaticoduodenectomy also received adjuvant CRT.
  • CONCLUSIONS: Ampullary cancers have a distinctly better treatment outcome than pancreatic adenocarcinomas.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / drug therapy. Common Bile Duct Neoplasms / radiotherapy

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  • (PMID = 17980502.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil
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48. Byun JR, Jahng JH, Song JC, Yu JS, Lee DK: Supine position endoscopic retrograde cholangiopancreatography in a patient with situs ambiguous with polysplenia. Dig Endosc; 2010 Oct;22(4):322-4
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  • Microscopic findings of the biopsy specimen of papillary mass were compatible with an adenocarcinoma of the ampulla of Vater.
  • [MeSH-major] Abnormalities, Multiple / pathology. Ampulla of Vater / pathology. Cholangiopancreatography, Endoscopic Retrograde. Common Bile Duct Neoplasms / radiography. Common Bile Duct Neoplasms / surgery. Spleen / abnormalities

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  • [Copyright] © 2010 The Authors. Digestive Endoscopy © 2010 Japan Gastroenterological Endoscopy Society.
  • (PMID = 21175488.001).
  • [ISSN] 1443-1661
  • [Journal-full-title] Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
  • [ISO-abbreviation] Dig Endosc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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49. Parthasarathy S, Pottakkat B, Yootla M, Reddy SN, Reddy KM: Synchronous adenocarcinomas of the papilla major and minor. JOP; 2008;9(3):332-4
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  • There was a growth in the ampulla of Vater and another in the region of the minor duodenal papilla.
  • [MeSH-major] Adenocarcinoma / diagnosis. Ampulla of Vater. Carcinoma, Pancreatic Ductal / complications. Carcinoma, Pancreatic Ductal / diagnosis. Common Bile Duct Neoplasms / complications. Common Bile Duct Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Pancreatic Ducts

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  • (PMID = 18469449.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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50. Ouaïssi M, Sielezneff I, Alves A, Pirro N, Heyries L, Robitail S, Consentino B, Payan MJ, Valleur P, Panis Y, Sastre B: [Long term outcome following 26 surgical ampullectomies]. Ann Chir; 2006 May;131(5):322-7
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  • Ampullectomy is an alternative to PD for benign ampulloma or, in high-risk patients, for invasive carcinoma.
  • CONCLUSION: Ampullectomy is a good alternative to PD in case of benign or non-invasive malignant ampullary lesion, including in selected cases of FAP.
  • [MeSH-major] Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / surgery. Adenoma / surgery. Adenomatous Polyposis Coli / surgery. Adult. Aged. Carcinoma in Situ / surgery. Cause of Death. Common Bile Duct Diseases / surgery. Female. Follow-Up Studies. Granuloma, Plasma Cell / surgery. Humans. Longitudinal Studies. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Retrospective Studies. Somatostatinoma / surgery. Survival Rate. Treatment Outcome

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  • (PMID = 16615931.001).
  • [ISSN] 0003-3944
  • [Journal-full-title] Annales de chirurgie
  • [ISO-abbreviation] Ann Chir
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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51. Albagli RO, Carvalho GS, Mali Junior J, Eulálio JM, de Melo EL: Comparative study of the radical and standard lymphadenectomy in the surgical treatment of adenocarcinoma of the ampula of Vater. Rev Col Bras Cir; 2010 Dec;37(6):420-5
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  • [Title] Comparative study of the radical and standard lymphadenectomy in the surgical treatment of adenocarcinoma of the ampula of Vater.
  • OBJECTIVE: To evaluate the morbidity and mortality in patients undergoing surgical pancreatoduodenectomy (PD) in standard and radical lymphadenectomy for adenocarcinoma of papilla, analyzing the prognostic factors related to overall and disease-free survival.
  • METHODS: Were analyzed retrospectively from 1999 to 2007, in the Department of Abdominal and Pelvic Surgery (INCa-RJ), 50 cases of PD for adenocarcinoma of the duodenal papilla divided into two groups according to lymphadenectomy (group A: standard lymphadenectomy and group B: radical lymphadenectomy).
  • Further studies should be conducted to evaluate the real role of radical lymphadenectomy in adenocarcinoma of the duodenal papilla.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Lymph Node Excision / methods

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  • (PMID = 21340257.001).
  • [ISSN] 1809-4546
  • [Journal-full-title] Revista do Colégio Brasileiro de Cirurgiões
  • [ISO-abbreviation] Rev Col Bras Cir
  • [Language] eng; por
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Brazil
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52. Winter JM, Cameron JL, Olino K, Herman JM, de Jong MC, Hruban RH, Wolfgang CL, Eckhauser F, Edil BH, Choti MA, Schulick RD, Pawlik TM: Clinicopathologic analysis of ampullary neoplasms in 450 patients: implications for surgical strategy and long-term prognosis. J Gastrointest Surg; 2010 Feb;14(2):379-87
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathologic analysis of ampullary neoplasms in 450 patients: implications for surgical strategy and long-term prognosis.
  • BACKGROUND: Whether ampullary neoplasms are best surgically managed by pancreaticoduodenectomy versus local ampullectomy is controversial.
  • We sought to examine the outcome of patients undergoing pancreaticoduodenectomy versus ampullectomy, as well as to identify factors predictive of lymph node metastasis in patients with ampullary neoplasms.
  • METHODS: Between 1970 and 2007, 450 patients who underwent surgical resection of ampullary adenoma or adenocarcinoma were identified from a prospective, single-institution database.
  • Final diagnosis was invasive adenocarcinoma (77.1%) or adenoma (22.9%).
  • Median tumor size was similar for adenomas associated with an adenocarcinoma (2.5 cm) versus adenomas without invasive cancer (2.9 cm; P=0.71).
  • Metastatic disease to regional lymph nodes was present in 54.5% patients with adenocarcinoma.
  • CONCLUSION: When surgery is indicated, radical resection is required for early invasive adenocarcinoma of the ampulla of Vater, as lymph node metastases are present in nearly 30% of patients with T1 disease.
  • Pancreaticoduodenectomy should be the preferred approach for most ampullary neoplasms that require surgical resection.
  • [MeSH-major] Adenocarcinoma / surgery. Adenoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery

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  • (PMID = 19911239.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / 1KL2RR025006-01
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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53. Brown KM, Tompkins AJ, Yong S, Aranha GV, Shoup M: Pancreaticoduodenectomy is curative in the majority of patients with node-negative ampullary cancer. Arch Surg; 2005 Jun;140(6):529-32; discussion 532-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pancreaticoduodenectomy is curative in the majority of patients with node-negative ampullary cancer.
  • HYPOTHESIS: Survival following resection for ampullary carcinoma may be influenced by 1 or more clinical or pathologic variables.
  • PATIENTS: From July 1, 1991, through April 30, 2004, 72 patients (31 males and 41 females) were treated for ampullary carcinoma at Loyola University Medical Center, Maywood, Ill.
  • INTERVENTIONS: Whipple procedure for attempted cure in 51 patients with ampullary adenocarcinoma.
  • CONCLUSION: Pancreaticoduodenectomy is curative in 80% of patients with node-negative ampullary carcinomas.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Ampulla of Vater. Blood Loss, Surgical. Female. Humans. Lymph Nodes / pathology. Male. Middle Aged. Retrospective Studies. Survival Rate. Time Factors. Treatment Outcome

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  • [CommentIn] Arch Surg. 2005 Jul;140(7):708 [16027340.001]
  • (PMID = 15967899.001).
  • [ISSN] 0004-0010
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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54. Manta R, Conigliaro R, Castellani D, Messerotti A, Bertani H, Sabatino G, Vetruccio E, Losi L, Villanacci V, Bassotti G: Linear endoscopic ultrasonography vs magnetic resonance imaging in ampullary tumors. World J Gastroenterol; 2010 Nov 28;16(44):5592-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Linear endoscopic ultrasonography vs magnetic resonance imaging in ampullary tumors.
  • AIM: To assess linear endoscopic ultrasound (L-EUS) and magnetic resonance imaging (MRI) in biliary tract dilation and suspect small ampullary tumor.
  • METHODS: L-EUS and MRI data were compared in 24 patients with small ampullary tumors; all with subsequent histological confirmation.
  • RESULTS: A suspicion of ampullary tumor was present in 75% of MRI and all L-EUS examinations, with 80% agreement between EUS and histological findings at endoscopy.
  • CONCLUSION: L-EUS could be a useful adjunct as a diagnostic tool in the evaluation of patients with suspected ampullary tumors.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma / diagnosis. Ampulla of Vater / pathology. Ampulla of Vater / ultrasonography. Common Bile Duct Neoplasms / diagnosis. Endosonography. Magnetic Resonance Imaging

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  • (PMID = 21105192.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2992677
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55. Barbu ST, Zărnescu NO, Andrén-Sandberg T: [Report from the 37th annual meeting of the "European Pancreatic Club." Graz, Austria, 6-8 July 2005]. Chirurgia (Bucur); 2006 Mar-Apr;101(2):209-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma. Ampulla of Vater. Common Bile Duct Neoplasms. Pancreatic Neoplasms. Pancreatitis

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  • (PMID = 16752690.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] Congresses
  • [Publication-country] Romania
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56. de Paiva Haddad LB, Patzina RA, Penteado S, Montagnini AL, da Cunha JE, Machado MC, Jukemura J: Lymph node involvement and not the histophatologic subtype is correlated with outcome after resection of adenocarcinoma of the ampulla of vater. J Gastrointest Surg; 2010 Apr;14(4):719-28
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  • [Title] Lymph node involvement and not the histophatologic subtype is correlated with outcome after resection of adenocarcinoma of the ampulla of vater.
  • BACKGROUND: Intestinal and pancreaticobiliary types of Vater's ampulla adenocarcinoma have been considered as having different biologic behavior and prognosis.
  • The aim of the present study was to determine the best immunohistochemical panel for tumor classification and to analyze the survival of patients having these histological types of adenocarcinoma.
  • METHOD: Ninety-seven resected ampullary adenocarcinomas were histologically classified, and the prognosis factors were analyzed.
  • RESULTS: Forty-three Vater's ampulla carcinomas were histologically classified as intestinal type, 47 as pancreaticobiliary, and seven as other types.
  • CONCLUSION: The immunohistochemical expression of CDX2, MUC1, and MUC2 allows a reproducible classification of ampullary carcinomas.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. Lymphatic Metastasis / pathology

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  • (PMID = 20107918.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CDX2 Transcription Factor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / MUC1 protein, human; 0 / MUC2 protein, human; 0 / Mucin-1; 0 / Mucin-2
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57. Hol JW, Stuifbergen WN, Teepen JL, van Laarhoven CJ: Giant Brunner's hamartomas of the duodenum and obstructive jaundice. An overview of the literature and suspicion of malignancy in a case. Dig Surg; 2007;24(6):452-5
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  • RESULTS: Pathological analysis of the resection specimen revealed multiple BGHs and an adenocarcinoma of the papilla of Vater (PoV).
  • CONCLUSION: It is likely that previous reports of malignant degeneration of BGHs may actually have been cases involving the coexistence of a PoV adenocarcinoma.
  • Physicians need to be alert when a patient presents with BGH accompanied with obstructive jaundice for simultaneously occurring PoV adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / epidemiology. Ampulla of Vater. Brunner Glands. Common Bile Duct Neoplasms / epidemiology. Duodenal Diseases / epidemiology. Hamartoma / epidemiology. Jaundice, Obstructive / etiology

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  • [Copyright] Copyright (c) 2007 S. Karger AG, Basel
  • (PMID = 18025786.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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58. Barauskas G, Gulbinas A, Pundzius J: Results of surgical treatment of carcinoma of papilla of Vater. Medicina (Kaunas); 2007;43(6):455-62
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  • [Title] Results of surgical treatment of carcinoma of papilla of Vater.
  • Adenocarcinoma is the most common malignant tumor of the ampulla, but in general, it is still rare.
  • To evaluate immediate postoperative and long-term results, we have collected data prospectively in a specially created database on 21 consecutive patients with adenocarcinoma of the papilla of Vater, operated on at the Department of Surgery, Kaunas University of Medicine Hospital.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / surgery

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  • (PMID = 17637516.001).
  • [ISSN] 1648-9144
  • [Journal-full-title] Medicina (Kaunas, Lithuania)
  • [ISO-abbreviation] Medicina (Kaunas)
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Lithuania
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59. Loh KY, Yushak AW: Images in clinical medicine. Virchow's node (Troisier's sign). N Engl J Med; 2007 Jul 19;357(3):282
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma / secondary. Common Bile Duct Neoplasms / pathology. Lymph Nodes / pathology
  • [MeSH-minor] Ampulla of Vater / pathology. Female. Humans. Liver Neoplasms / radiography. Liver Neoplasms / secondary. Lung Neoplasms / radiography. Lung Neoplasms / secondary. Lymphatic Metastasis. Middle Aged. Neck

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  • (PMID = 17634463.001).
  • [ISSN] 1533-4406
  • [Journal-full-title] The New England journal of medicine
  • [ISO-abbreviation] N. Engl. J. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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60. Keene KS, Rich TA, Penberthy DR, Shepard RC, Adams R, Jones RS: Clinical experience with chronomodulated infusional 5-fluorouracil chemoradiotherapy for pancreatic adenocarcinoma. Int J Radiat Oncol Biol Phys; 2005 May 1;62(1):97-103
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  • [Title] Clinical experience with chronomodulated infusional 5-fluorouracil chemoradiotherapy for pancreatic adenocarcinoma.
  • PURPOSE: To evaluate retrospectively the efficacy and chronic toxicities of concurrent radiotherapy and chronomodulated infusion 5-fluorouracil (5-FU) in patients with pancreatic adenocarcinoma.
  • METHODS AND MATERIALS: Twenty-eight patients with pancreatic adenocarcinoma were treated between January 1997 and May 2000 with 5-FU chronomodulated chemoradiotherapy.
  • If the 3 patients with carcinoma of the ampulla were removed from the data set, the mean overall survival in the resected patients was 34 months, with a 3-year and 5-year actuarial survival rate of 40% and 17%, respectively.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / radiotherapy. Antimetabolites, Antineoplastic / administration & dosage. Chronotherapy. Fluorouracil / administration & dosage. Pancreatic Neoplasms / drug therapy. Pancreatic Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Ampulla of Vater. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / radiotherapy. Retrospective Studies. Survival Rate

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  • (PMID = 15850908.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; U3P01618RT / Fluorouracil
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61. Nagano Y, Sekido H, Matsuoi K, Ohtsuki K, Gorai K, Kunisaki C, Ike H, Imada T, Shimada H: Successful pancreatoduodenectomy for carcinoma of the ampulla of vater after esophagectomy with remnant gastrectomy. Hepatogastroenterology; 2005 May-Jun;52(63):933-5
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  • [Title] Successful pancreatoduodenectomy for carcinoma of the ampulla of vater after esophagectomy with remnant gastrectomy.
  • Duodenoscopy was performed and showed the protruded lesion of the ampulla of Vater, biopsied specimens from this tumor revealed adenocarcinomas.
  • The problem in this case was that the rt middle colic artery (MCA), and the middle colic vein (MCV) tend to be injured because these vessels are situated near the caudal region of the pancreas.
  • Double cancer of the ampulla of Vater and the esophagus are extremely rare, with only 4 cases reported.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Esophageal Neoplasms / surgery. Esophagectomy. Gastrectomy. Gastric Stump / surgery. Neoplasms, Multiple Primary / surgery. Pancreaticoduodenectomy. Postoperative Complications / surgery

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  • (PMID = 15966235.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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62. Kameyama T, Yasunaga Y, Kizu T, Miyoshi R, Watanabe C, Yamamoto S, Matsumoto Y, Inui Y, Hayashi N, Fukuchi N, Hasuike Y, Koshino T, Izumiyama K, Kohro T, Nishikawa M: [A case of primary duodenal cancer near the papilla of Vater which had initial symptoms of obstructive jaundice]. Nihon Shokakibyo Gakkai Zasshi; 2006 Jun;103(6):636-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of primary duodenal cancer near the papilla of Vater which had initial symptoms of obstructive jaundice].
  • A type 2-like mass lesion was found near the papilla of Vater during the endoscopic retrograde cholangiopancreatography and was histologically proven to be a well-differentiated adenocarcinoma.
  • A diagnosis of obstructive jaundice due to primary duodenal cancer arising near the papilla of Vater was made.
  • A histopathological examination of the resected specimen concerning the location and manner of invasion of cancer cells revealed that the cancer arose from the duodenal mucosa near the papilla of Vater.
  • [MeSH-major] Adenocarcinoma / diagnosis. Ampulla of Vater. Duodenal Neoplasms / diagnosis. Jaundice, Obstructive / etiology

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  • (PMID = 16800286.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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63. O'Connor JK, Sause WT, Hazard LJ, Belnap LP, Noyes RD: Survival after attempted surgical resection and intraoperative radiation therapy for pancreatic and periampullary adenocarcinoma. Int J Radiat Oncol Biol Phys; 2005 Nov 15;63(4):1060-6
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  • [Title] Survival after attempted surgical resection and intraoperative radiation therapy for pancreatic and periampullary adenocarcinoma.
  • PURPOSE: To evaluate a single institution's experience with intraoperative radiation therapy (IORT) in combination with attempted surgical resection for pancreatic and periampullary adenocarcinoma.
  • METHODS AND MATERIALS: From May 1986 until June 2001, 77 patients at LDS Hospital underwent attempted surgical resection and IORT for pancreatic or periampullary adenocarcinoma.
  • RESULTS: Patients undergoing a potentially curative resection and IORT for periampullary adenocarcinoma had a median survival of 167 months and a 56% 5-year actuarial survival, compared with a median survival of 16 months and a 19% 5-year actuarial survival for patients undergoing the same treatment for pancreatic adenocarcinoma (p = 0.03).
  • CONCLUSIONS: Intraoperative radiation therapy is well tolerated and does not increase the morbidity or mortality of potentially curative surgical resection for pancreatic or periampullary adenocarcinoma.
  • Patients with periampullary adenocarcinoma have a better prognosis than those with pancreatic adenocarcinoma, and patients with unresectable pancreatic disease fared worse.
  • [MeSH-major] Adenocarcinoma / mortality. Ampulla of Vater. Common Bile Duct Neoplasms / mortality. Pancreatic Neoplasms / mortality

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  • (PMID = 15978737.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] U3P01618RT / Fluorouracil
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64. Chang YT, Hsu C, Jeng YM, Chang MC, Wei SC, Wong JM: Expression of the caudal-type homeodomain transcription factor CDX2 is related to clinical outcome in biliary tract carcinoma. J Gastroenterol Hepatol; 2007 Mar;22(3):389-94
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  • Recent studies have reported that expression of CDX2 was an independent marker of outcome in patients with resected adenocarcinoma of ampulla of Vater, gastric cancer, and colon cancer.

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  • (PMID = 17295772.001).
  • [ISSN] 0815-9319
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / Trans-Activators; 156560-97-3 / Cdx-2-3 protein
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65. Ogawa H, Itoh S, Ikeda M, Suzuki K, Naganawa S: Intraductal papillary mucinous neoplasm of the pancreas: assessment of the likelihood of invasiveness with multisection CT. Radiology; 2008 Sep;248(3):876-86
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  • Two radiologists blinded to the pathologic assessment of malignancy or parenchymal invasion of IPMN retrospectively evaluated CT images of 61 consecutive surgically resected tumors (26 adenomas, 15 noninvasive carcinomas, and 20 invasive carcinomas) in patients who underwent multiphase contrast material-enhanced CT with 0.5- or 1-mm collimation.
  • RESULTS: The following findings showed significant differences among the three groups: maximum diameter of the main pancreatic duct (MPD), size (length of major axis) of the largest mural nodule in the MPD or in any associated cystic lesion, abnormal attenuating area in the surrounding parenchyma, calcification in the lesion, protrusion of the MPD into the ampulla of Vater, and bile duct dilatation.
  • CONCLUSION: Multisection CT is useful for distinguishing among adenoma, noninvasive carcinoma, and invasive carcinoma in patients with IPMN.
  • [MeSH-major] Adenocarcinoma, Mucinous / radiography. Adenoma / radiography. Pancreatic Neoplasms / radiography. Papilloma, Intraductal / radiography. Radiographic Image Enhancement / methods. Tomography, X-Ray Computed / methods

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  • [Copyright] RSNA, 2008
  • (PMID = 18632526.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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66. Ito K, Fujita N, Noda Y, Kobayashi G, Horaguchi J, Takasawa O, Obana T: Preoperative evaluation of ampullary neoplasm with EUS and transpapillary intraductal US: a prospective and histopathologically controlled study. Gastrointest Endosc; 2007 Oct;66(4):740-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Preoperative evaluation of ampullary neoplasm with EUS and transpapillary intraductal US: a prospective and histopathologically controlled study.
  • BACKGROUND: Endoscopic papillectomy is performed in selected patients with ampullary neoplasm, and, thus, accurate preoperative tumor staging is indispensable for its application.
  • PATIENTS AND INTERVENTIONS: EUS and transpapillary intraductal US (IDUS) were performed in 40 patients with ampullary neoplasm before surgery (n = 30) or endoscopic papillectomy (n = 10).
  • MAIN OUTCOME MEASUREMENTS AND RESULTS: Thirty-three patients had adenocarcinoma (14 pT1, 11 pT2, 8 pT3-4) and 7 had adenoma.
  • CONCLUSION: Although IDUS had a tendency of overestimation in tumor staging for ampullary neoplasm, it can provide useful information for making therapeutic decisions, especially in cases appropriate for endoscopic papillectomy.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms. Duodenoscopy / methods. Endosonography / methods. Preoperative Care / methods. Sphincterotomy, Endoscopic / methods
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adenocarcinoma / ultrasonography. Adenoma / pathology. Adenoma / surgery. Adenoma / ultrasonography. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Prospective Studies. Reproducibility of Results

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  • (PMID = 17905017.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] United States
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67. Gaedcke J, Gunawan B, Grade M, Szöke R, Liersch T, Becker H, Ghadimi BM: The mesopancreas is the primary site for R1 resection in pancreatic head cancer: relevance for clinical trials. Langenbecks Arch Surg; 2010 Apr;395(4):451-8
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  • RESULTS: Thirty-five patients were excluded from the analysis owing to the pathohistological diagnosis; only pancreatic ductal adenocarcinoma, distal bile duct adenocarcinoma, and periampullary adenocarcinoma were included.

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  • (PMID = 19418067.001).
  • [ISSN] 1435-2451
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2848727
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68. Stipa F, Alessandroni L, Cimitan A, Burza A, Cavallotti C, Cavallini M, Tersigni R, Ziparo V: [Pancreaticoduodenectomy for adenocarcinoma of the pancreatic head and papilla of Vater]. Minerva Chir; 2009 Aug;64(4):395-406
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pancreaticoduodenectomy for adenocarcinoma of the pancreatic head and papilla of Vater].
  • [Transliterated title] Duodenocefalopancreatectomia per adenocarcinoma della testa del pancreas e della papilla di Vater.
  • AIM: The authors report their consecutive experience in the surgical management of adenocarcinoma (ADC) of head of pancreas and papilla of Vater, in order to review the available literature.
  • METHODS: One hundred and seventy cases (131 in the head of pancreas and 39 in the papilla of Vater) were operated upon for ADC by radical pancreaticoduodenectomy in the period 1972-2005.
  • In ADC of the papilla of Vater, for the same stages, the 5-year survival rates were 54.4%, 51.4%, 0% and 37.5%, respectively.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Neoplasms, Multiple Primary / surgery. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy

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  • (PMID = 19648859.001).
  • [ISSN] 0026-4733
  • [Journal-full-title] Minerva chirurgica
  • [ISO-abbreviation] Minerva Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 79
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69. Graber I, Dumas R, Filoche B, Boyer J, Coumaros D, Lamouliatte H, Legoux JL, Napoléon B, Ponchon T, Société Française d'Endoscopie Digestive (SFED): The efficacy and safety of duodenal stenting: a prospective multicenter study. Endoscopy; 2007 Sep;39(9):784-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PATIENTS AND METHODS: A total of 51 patients were selected (mean age 72), the majority (69%) having pancreatic adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / complications. Duodenal Obstruction / therapy. Palliative Care. Pancreatic Neoplasms / complications. Prosthesis Implantation. Stents
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Ampulla of Vater. Common Bile Duct Neoplasms / complications. Constriction, Pathologic. Duodenoscopy. Female. Humans. Male. Middle Aged. Neoplasms / complications. Prospective Studies. Treatment Outcome

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  • (PMID = 17703386.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study
  • [Publication-country] Germany
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70. Ishibashi Y, Ito Y, Omori K, Wakabayashi K: Signet ring cell carcinoma of the ampulla of vater. A case report. JOP; 2009;10(6):690-3
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  • [Title] Signet ring cell carcinoma of the ampulla of vater. A case report.
  • CONTEXT: Signet ring cell carcinoma of the ampulla of Vater is extremely rare and only 12 cases have previously been described in the English language literature.
  • We report a case of advanced signet ring cell carcinoma of the ampulla of Vater, with invasion of the duodenum and pancreas.
  • Duodenoscopy indicated an irregularly shaped erosion on the ampulla of Vater.
  • Histological examination of a biopsy revealed adenocarcinoma.
  • The diagnosis was carcinoma of the ampulla of Vater, and a pancreaticoduodenectomy was performed.
  • [MeSH-major] Ampulla of Vater. Carcinoma, Signet Ring Cell / diagnosis. Common Bile Duct Neoplasms / diagnosis

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  • (PMID = 19890196.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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71. Sugimoto M, Takada T, Yasuda H, Nagashima I, Amano H, Yoshida M, Miura F, Uchida T, Isaka T, Toyota N, Wada K, Takagi K, Kato K: Exceptional ultra-late recurrence of papilla Vater carcinoma after pancreaticoduodenectomy: two cases at 17 and 25 years. Hepatogastroenterology; 2005 May-Jun;52(63):940-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Exceptional ultra-late recurrence of papilla Vater carcinoma after pancreaticoduodenectomy: two cases at 17 and 25 years.
  • Cancer of the papilla Vater can remain clinically quiescent for decades prior to regional or distant recurrence.
  • This protracted disease-free interval challenges the concept of a "cure" for cancer of the papilla Vater.
  • In the first case reported here, a 74-year-old female underwent pancreaticoduodenectomy in 1985 for cancer of the papilla Vater revealed histologically as a well-differentiated papillotubular adenocarcinoma, stage IA (UICC classification).
  • Multiple hepatic recurrences were found 17 years after the operation; hepatic biopsy showed histologically well to moderately differentiated papillotubular adenocarcinoma.
  • The second case is that of an 82-year-old female who underwent pancreaticoduodenectomy in 1974 for cancer of the papilla Vater, histologically a well-differentiated adenocarcinoma, stage IA.
  • Autopsy showed histologically well to moderately differentiated adenocarcinoma at the locations indicated, together with lung and lymph node metastases.
  • The ultra-late recurrences (>15 years) in these cases are highly exceptional and, to our knowledge, this is the first report of such recurrences in cancer of the papilla Vater.
  • Because cancer of the papilla Vater can recur in many prognostically favorable cases after prolonged disease-free intervals, the possibility of delayed recurrence should not be ignored.
  • [MeSH-major] Adenocarcinoma / diagnosis. Ampulla of Vater / surgery. Neoplasm Recurrence, Local / diagnosis. Pancreaticoduodenectomy. Postoperative Complications / diagnosis

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  • (PMID = 15966237.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen
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72. Molina Granados JF, Escribano Fernández J, Vida Pérez L, Barrena Baena P: [Biliary obstruction due to adenocarcinoma of the ampulla of Vater ten years after orthotopic liver transplantation]. Radiologia; 2009 Nov-Dec;51(6):610-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Biliary obstruction due to adenocarcinoma of the ampulla of Vater ten years after orthotopic liver transplantation].
  • [Transliterated title] Obstrucción biliar por adenocarcinoma de la papila de Vater en un paciente con trasplante hepático ortotópico.
  • Adenocarcinoma of the ampulla of Vater should be considered among the causes of biliary obstruction in patients with orthotopic liver transplants.
  • [MeSH-major] Adenocarcinoma / complications. Ampulla of Vater. Cholestasis / etiology. Common Bile Duct Neoplasms / complications. Liver Transplantation / adverse effects

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  • (PMID = 19836032.001).
  • [ISSN] 0033-8338
  • [Journal-full-title] Radiología
  • [ISO-abbreviation] Radiologia
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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73. Artifon EL, Couto D Jr, Sakai P, da Silveira EB: Prospective evaluation of EUS versus CT scan for staging of ampullary cancer. Gastrointest Endosc; 2009 Aug;70(2):290-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prospective evaluation of EUS versus CT scan for staging of ampullary cancer.
  • However, ampullary cancer carries a better prognosis and is often diagnosed when curative treatment is still possible.
  • (1) To determine the test performance characteristics of EUS and CT in loco-regional staging of ampullary neoplasms, and (2) to determine the impact of CT scan results on the test performance characteristics of EUS.
  • Further studies to determine the role of specialized CT protocols in patients with ampullary malignancies are needed.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater. Common Bile Duct Neoplasms / pathology. Endosonography. Tomography, X-Ray Computed

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  • (PMID = 19523619.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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74. Overman MJ, Varadhachary GR, Kopetz S, Adinin R, Lin E, Morris JS, Eng C, Abbruzzese JL, Wolff RA: Phase II study of capecitabine and oxaliplatin for advanced adenocarcinoma of the small bowel and ampulla of Vater. J Clin Oncol; 2009 Jun 1;27(16):2598-603
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phase II study of capecitabine and oxaliplatin for advanced adenocarcinoma of the small bowel and ampulla of Vater.
  • PURPOSE: Adenocarcinomas of the small bowel and ampulla of Vater represent rare cancers that have limited data regarding first-line therapy.
  • We conducted a phase II trial to evaluate the benefit of capecitabine in combination with oxaliplatin (CAPOX) in patients with advanced adenocarcinoma of small bowel or ampullary origin.
  • CAPOX should be considered a new standard regimen for advanced small bowel and ampullary adenocarcinomas.
  • [MeSH-major] Adenocarcinoma / drug therapy. Ampulla of Vater / pathology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Common Bile Duct Neoplasms / drug therapy. Intestinal Neoplasms / drug therapy. Intestine, Small / pathology

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  • (PMID = 19164203.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil
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75. Fathy O, Wahab MA, Elghwalby N, Sultan A, EL-Ebidy G, Hak NG, Abu Zeid M, Abd-Allah T, El-Shobary M, Fouad A, Kandeel T, Abo Elenien A, Abd El-Raouf A, Hamdy E, Sultan AM, Hamdy E, Ezzat F: 216 cases of pancreaticoduodenectomy: risk factors for postoperative complications. Hepatogastroenterology; 2008 May-Jun;55(84):1093-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Periampullary adenocarcinoma was found in 204 (94.4%) patients, chronic pancreatitis in 9 (4.2%) patients, 2 patients with solid and papillary neoplasm, and 1 patient with NHL (Non-Hodgkin's Lymphoma).
  • [MeSH-major] Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy. Postoperative Complications / etiology

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  • (PMID = 18705336.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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76. Bloomston M, Ellison EC, Muscarella P, Al-Saif O, Martin EW, Melvin WS, Frankel WL: Stromal osteonectin overexpression is associated with poor outcome in patients with ampullary cancer. Ann Surg Oncol; 2007 Jan;14(1):211-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Stromal osteonectin overexpression is associated with poor outcome in patients with ampullary cancer.
  • We determined the osteonectin expression and its influence on survival in patients with ampullary carcinoma.
  • METHODS: Tissue microarrays were constructed from the tumors of 56 patients with ampullary cancer undergoing pancreaticoduodenectomy.
  • Median follow-up for all living patients with ampullary cancer was 69.6 months.
  • RESULTS: Osteonectin was significantly (P < .05, Fisher's exact test) overexpressed in the stroma of ampullary cancers (90%) relative to chronic pancreatitis (62%) and normal pancreas (0%).
  • CONCLUSIONS: Although the importance of tumor-stroma interactions in periampullary cancers is not fully understood, our data suggest that osteonectin is an integral stromal element in ampullary cancers, and its overexpression is associated with decreased survival.
  • [MeSH-major] Adenocarcinoma / chemistry. Ampulla of Vater. Biomarkers, Tumor / analysis. Common Bile Duct Neoplasms / chemistry. Osteonectin / analysis

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  • (PMID = 17080236.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MUC2 protein, human; 0 / Mucin-1; 0 / Mucin-2; 0 / Mucins; 0 / Osteonectin; 106441-73-0 / Osteopontin
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77. Sa Cunha A, Larroudé D, Laurent C, Rault A, Collet D, Masson B: [Value of surgical ampullectomy in the management of benign ampullary tumors]. Ann Chir; 2005 Jan;130(1):32-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Value of surgical ampullectomy in the management of benign ampullary tumors].
  • [Transliterated title] Intérêt de l'ampullectomie chirurgicale dans la prise en charge des lésions bénignes de l'ampoule de Vater.
  • AIM OF THE STUDY: To report the results of transduodenal excision (TDE) for tumors of the ampulla of Vater.
  • PATIENTS AND METHODS: From 1998 to 2003, 10 patients underwent a transduodenal excision for presumed benign tumors of the ampulla of Vater.
  • The final pathology showed adenoma in 8 patients, an adenocarcinoma in one patient and inflammatory lesions in other one.
  • Patient with an invasive cancer developed recurrence.
  • CONCLUSION: Transduodenal excision is safe and effective treatment for benign ampullary tumors.
  • [MeSH-major] Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Postoperative Complications

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  • (PMID = 15664374.001).
  • [ISSN] 0003-3944
  • [Journal-full-title] Annales de chirurgie
  • [ISO-abbreviation] Ann Chir
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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78. Park JS, Yoon DS, Kim KS, Choi JS, Lee WJ, Chi HS, Kim BR: Factors influencing recurrence after curative resection for ampulla of Vater carcinoma. J Surg Oncol; 2007 Mar 15;95(4):286-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Factors influencing recurrence after curative resection for ampulla of Vater carcinoma.
  • BACKGROUND: Carcinoma of the ampulla of Vater has a relatively higher resection rate, lower recurrence rate, and more favorable prognosis than other malignant tumors of the periampullary region.
  • Because of the relative low incidence of carcinoma of the ampulla of Vater, there have been few reports on the patterns and risk factors of recurrence after curative resection.
  • The aim of this study was to evaluate the patterns and risk factors of recurrence after curative resection of ampulla of Vater carcinoma.
  • MATERIALS AND METHODS: Between January 1992 and December 2002, 102 patients received radical resection for ampulla of Vater carcinoma at Yonsei University Medical Center.
  • Lymph node metastasis was identified as an independent factor of tumor recurrence after curative resection for ampulla of Vater carcinoma.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Duodenal Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Pancreatic Neoplasms / surgery

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 17326125.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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79. Hansel DE, Rahman A, Wilentz RE, Shih IeM, McMaster MT, Yeo CJ, Maitra A: HLA-G upregulation in pre-malignant and malignant lesions of the gastrointestinal tract. Int J Gastrointest Cancer; 2005;35(1):15-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We have examined HLA-G expression in a number of human gastrointestinal malignancies, including pancreatic ductal adenocarcinoma, ampullary cancer, biliary cancer, and colorectal cancer by immunolabeling analysis.
  • In addition, we utilized the neoplastic progression model of colorectal cancer to evaluate HLA-G protein expression in normal colon, tubulovillous adenomas, invasive cancer, and liver metastases arising from colorectal cancer.

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  • (PMID = 15722570.001).
  • [ISSN] 1537-3649
  • [Journal-full-title] International journal of gastrointestinal cancer
  • [ISO-abbreviation] Int J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / HLA Antigens; 0 / HLA-G Antigens; 0 / Histocompatibility Antigens Class I
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80. Schirmacher P, Büchler MW: Ampullary adenocarcinoma - differentiation matters. BMC Cancer; 2008;8:251
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ampullary adenocarcinoma - differentiation matters.
  • The periampullary region gives rise to two main subtypes of adenocarcinoma that show either pancreatobiliary or intestinal differentiation.
  • This fuels the discussion about maintaining ampullary cancer as a separate entity.
  • [MeSH-major] Adenocarcinoma / diagnosis. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / diagnosis

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  • (PMID = 18761739.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
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81. Iacono C, Verlato G, Zamboni G, Scarpa A, Montresor E, Capelli P, Bortolasi L, Serio G: Adenocarcinoma of the ampulla of Vater: T-stage, chromosome 17p allelic loss, and extended pancreaticoduodenectomy are relevant prognostic factors. J Gastrointest Surg; 2007 May;11(5):578-88
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma of the ampulla of Vater: T-stage, chromosome 17p allelic loss, and extended pancreaticoduodenectomy are relevant prognostic factors.
  • OBJECTIVE: To evaluate the prognostic significance of different clinico-pathological and molecular factors, and to compare survival after standard and extended pancreaticoduodenectomy (PD) in ampulla of Vater adenocarcinoma (AVAC).
  • CONCLUSION: MSI and chromosome 17p status allow to better define prognosis within ampullary cancers at the same stage.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater / pathology. Chromosomes, Human, Pair 17 / genetics. Common Bile Duct Neoplasms / pathology. Loss of Heterozygosity / genetics. Pancreaticoduodenectomy

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  • (PMID = 17468917.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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82. Westgaard A, Tafjord S, Farstad IN, Cvancarova M, Eide TJ, Mathisen O, Clausen OP, Gladhaug IP: Resectable adenocarcinomas in the pancreatic head: the retroperitoneal resection margin is an independent prognostic factor. BMC Cancer; 2008;8:5
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  • BACKGROUND: The retroperitoneal margin is frequently microscopically tumour positive in non-curative periampullary adenocarcinoma resections.
  • The periampullary cancer origin (pancreas, ampulla, distal bile duct or duodenum) was registered prospectively and reevaluated retrospectively.
  • Associations between histopathologic factors and survival were also evaluated by unadjusted and adjusted Cox regression analysis, including stepwise variable selection, in order to identify factors that independently predict a poor prognosis after periampullary adenocarcinoma resections.
  • In microscopically curative (R0) resections (n = 74), pancreatic tumour origin was the only factor that independently predicted a poor prognosis (p < 0.001; HR 4.71 for pancreatic versus ampullary; CI 2.13-10.4).
  • CONCLUSION: Serial perpendicular sectioning of the retroperitoneal resection margin demonstrates that tumour involvement of this margin independently predicts survival after pancreaticoduodenectomy for adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / surgery. Pancreatic Neoplasms / surgery. Retroperitoneal Neoplasms / surgery. Retroperitoneal Space / pathology. Retroperitoneal Space / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Ampulla of Vater / pathology. Disease-Free Survival. Female. Humans. Male. Middle Aged. Pancreaticoduodenectomy. Prognosis. Retrospective Studies

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  • (PMID = 18194510.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2249586
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83. Agaram NP, Shia J, Tang LH, Klimstra DS: DNA mismatch repair deficiency in ampullary carcinoma: a morphologic and immunohistochemical study of 54 cases. Am J Clin Pathol; 2010 May;133(5):772-80
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  • [Title] DNA mismatch repair deficiency in ampullary carcinoma: a morphologic and immunohistochemical study of 54 cases.
  • The significance of DNA mismatch repair (MMR) deficiency or microsatellite instability (MSI) in ampullary carcinomas remains to be defined.
  • This study evaluated the MMR status in 54 consecutive ampullary adenocarcinomas by immunohistochemical and morphologic studies.
  • Thus, MMR deficiency occurs in ampullary carcinoma but appears less frequent than in colorectal carcinoma (CRC).
  • Typical MSI-high histologic features of CRC, such as increased TIL counts, seem to have similar yet subtly different implications in ampullary carcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. DNA Mismatch Repair / genetics. Nuclear Proteins

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  • (PMID = 20395525.001).
  • [ISSN] 1943-7722
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein; 0 / MLH1 protein, human; 0 / Nuclear Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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84. Ferrando Marco J, Pallas Regueira A, Moro Valdezate D, Fernández Martínez C: [Collision tumor of the ampulla of Vater: carcinoid and adenocarcinoma]. Rev Esp Enferm Dig; 2007 Apr;99(4):235-8
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  • [Title] [Collision tumor of the ampulla of Vater: carcinoid and adenocarcinoma].
  • We report the case of a periampullary collision tumor, in which a duodenal-wall carcinoid and an adenocarcinoma of the head of the pancreas coexisted.
  • Solid cords and nests of neuroendocrine cells in the duodenal wall formed the carcinoid tumor, whereas the other neoplasm was made up of a well-differentiated adenocarcinoma of the pancreas.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater. Carcinoid Tumor / pathology. Common Bile Duct Neoplasms / pathology. Duodenal Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 17590108.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 15
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85. Kalogeraki A, Tzardi M, Papadakis M, Stathopoulos E, Kouroumalis E, Zoras O: Apoptosis and cell proliferation correlated with tumor grade in patients with ampullary carcinoma. Acta Cytol; 2010 Jan-Feb;54(1):39-42
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  • [Title] Apoptosis and cell proliferation correlated with tumor grade in patients with ampullary carcinoma.
  • STUDY DESIGN: Forty patients (23 males and 17 females) aged 45-81 who underwent endoscopic retrograde cholangiopancreatography were diagnosed by cytology as having ampullary adenocarcinoma and the diagnoses were confirmed histologically after an operation.
  • RESULTS: The TUNEL indices were 0.4 +/- 0.07, 0.91 +/- 0.33 and 3.1 +/- 0.9 in well, moderate and poorly differentiated ampullary carcinoma, respectively.
  • The differences in both TUNEL and MIB-1 labeling indices were statistically significant between well, moderately and poorly differentiated ampullary carcinoma, and a positive correlation was found between TUNEL and the MIB-1 indices.
  • CONCLUSION: Apoptosis (cell death) and cell proliferation increase as the grade of the differentiation decreases in ampullary carcinoma, suggesting a rapid turnover of the tumor cells with lower grates of differentiation, and apoptosis may play an important role in the growth of the tumors in patients with ampullary carcinomas.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater / pathology. Apoptosis. Cell Proliferation. Common Bile Duct Neoplasms / pathology

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  • (PMID = 20306986.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Antinuclear; 0 / Antibodies, Monoclonal; 0 / MIB-1 antibody
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86. Nassar H, Albores-Saavedra J, Klimstra DS: High-grade neuroendocrine carcinoma of the ampulla of vater: a clinicopathologic and immunohistochemical analysis of 14 cases. Am J Surg Pathol; 2005 May;29(5):588-94
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  • [Title] High-grade neuroendocrine carcinoma of the ampulla of vater: a clinicopathologic and immunohistochemical analysis of 14 cases.
  • We describe the clinical and pathologic features of 14 cases of high-grade neuroendocrine carcinoma (HGNEC) of the ampulla of Vater classified according to WHO classification of lung tumors into small cell carcinoma (SCC, 6 cases) and large cell neuroendocrine carcinoma (LCNEC, 8 cases) types.
  • The immunohistochemical findings were compared with those of 13 cases of primary poorly differentiated ampullary adenocarcinomas (PDACA) lacking neuroendocrine morphology.
  • Overall, 64% of patients with ampullary HGNEC died of disease (mean follow-up, 14.5 months).
  • Two HGNECs were combined with a conventional adenocarcinoma and another with a squamous cell carcinoma component.
  • In conclusion, HGNECs of the ampulla are rare (2%-3% of ampullary tumors in our material).
  • The clinical course parallels that of their pulmonary counterparts and appears to be worse than that of locally advanced ampullary adenocarcinomas.
  • The association with adenoma and or conventional adenocarcinoma components may suggest a common pathway in the initial carcinogenesis of these two types of tumors.
  • Loss of Rb expression, a characteristic finding in pulmonary SCCs, is present in almost half of ampullary HGNECs.
  • Thus, there are differences in the molecular phenotypes of these two types of ampullary carcinoma, supporting the distinction of poorly differentiated carcinomas with a neuroendocrine phenotype from those without.
  • [MeSH-major] Ampulla of Vater / pathology. Carcinoma, Neuroendocrine / pathology. Common Bile Duct Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / chemistry. Adenocarcinoma / pathology. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Survival Rate

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  • (PMID = 15832081.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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87. Haddad O, Porcu-Buisson G, Sakr R, Guidicelli B, Letreut YP, Gamerre M: Diagnosis and management of adenocarcinoma of the ampulla of Vater during pregnancy. Eur J Obstet Gynecol Reprod Biol; 2005 Apr 1;119(2):246-9
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  • [Title] Diagnosis and management of adenocarcinoma of the ampulla of Vater during pregnancy.
  • Histology demonstrated carcinoma of the ampulla of Vater.
  • Acute non-invasive assessment and radical surgery improve outcome for both the mother and fetus.
  • [MeSH-major] Adenocarcinoma / diagnosis. Ampulla of Vater. Common Bile Duct Neoplasms / diagnosis. Pregnancy Complications, Neoplastic / diagnosis

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  • (PMID = 15808389.001).
  • [ISSN] 0301-2115
  • [Journal-full-title] European journal of obstetrics, gynecology, and reproductive biology
  • [ISO-abbreviation] Eur. J. Obstet. Gynecol. Reprod. Biol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
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88. Kirimlioğlu H, Türkmen I, Başsüllü N, Dirican A, Karadağ N, Kirimlioğlu V: The expression of matrix metalloproteinases in intrahepatic cholangiocarcinoma, hilar (Klatskin tumor), middle and distal extrahepatic cholangiocarcinoma, gallbladder cancer, and ampullary carcinoma: role of matrix metalloproteinases in tumor progression and prognosis. Turk J Gastroenterol; 2009 Mar;20(1):41-7
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  • [Title] The expression of matrix metalloproteinases in intrahepatic cholangiocarcinoma, hilar (Klatskin tumor), middle and distal extrahepatic cholangiocarcinoma, gallbladder cancer, and ampullary carcinoma: role of matrix metalloproteinases in tumor progression and prognosis.
  • Biliary neoplasms are classified into intra- and extrahepatic cholangiocarcinoma (Klatskin tumor, middle and distal extrahepatic tumors), gallbladder adenocarcinoma, and ampullary carcinoma.
  • METHODS: Ten gallbladder adenocarcinoma, 8 distal bile duct carcinomas (distal cholangiocarcinoma), 8 Klatskin tumors, 8 intrahepatic cholangiocarcinomas and 10 ampullary carcinomas were included in the study.
  • MMP-2 expression was detected in the distal part of the biliary ducts, in 75% (6/18) of cases and in the nontumoral epithelia of the ampullary region in 50% (5/10) of cases.
  • The metaplastic and dysplastic epithelia were positively stained in all of the gallbladder adenocarcinoma, distal cholangiocarcinoma and ampullary tumors.
  • The gallbladder adenocarcinoma, distal cholangiocarcinoma and ampullary carcinomas expressed MMP-2 in 30%, 37% and 40% of the cases, respectively.
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Ampulla of Vater / enzymology. Ampulla of Vater / pathology. Disease Progression. Gallbladder Neoplasms / metabolism. Gallbladder Neoplasms / pathology. Hepatic Duct, Common / enzymology. Hepatic Duct, Common / pathology. Humans. Immunohistochemistry. Klatskin Tumor / metabolism. Klatskin Tumor / pathology. Matrix Metalloproteinase 14 / metabolism. Matrix Metalloproteinase 2 / metabolism. Matrix Metalloproteinase 9 / metabolism. Neoplasm Invasiveness. Prognosis

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  • (PMID = 19330734.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] EC 3.4.24.- / Matrix Metalloproteinases; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9; EC 3.4.24.80 / Matrix Metalloproteinase 14
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89. Uchida H, Shibata K, Iwaki K, Kai S, Ohta M, Kitano S: Ampullary cancer and preoperative jaundice: possible indication of the minimal surgery. Hepatogastroenterology; 2009 Jul-Aug;56(93):1194-8
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  • [Title] Ampullary cancer and preoperative jaundice: possible indication of the minimal surgery.
  • BACKGROUND/AIMS: Obstructive jaundice is common symptom of carcinoma of the ampulla of Vater.
  • In addition, 12 of the 14 patients without jaundice and lymphatic invasion were diagnosed as T1N0 (stage IA) disease, and all the tumors were papillary or well-differentiated adenocarcinoma.
  • CONCLUSIONS: Preoperative jaundice may reflect advanced-stage in case of ampullary cancer.
  • Radical surgery may not be necessary in patients without preoperative jaundice if the tumor is diagnosed as a papillary or well-differentiated adenocarcinoma without lymphatic invasion.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / surgery. Jaundice, Obstructive / surgery
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Minimally Invasive Surgical Procedures. Pancreaticoduodenectomy. Prognosis. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 19760968.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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90. Jung MK, Cho CM, Park SY, Jeon SW, Tak WY, Kweon YO, Kim SK, Choi YH: Endoscopic resection of ampullary neoplasms: a single-center experience. Surg Endosc; 2009 Nov;23(11):2568-74
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  • [Title] Endoscopic resection of ampullary neoplasms: a single-center experience.
  • BACKGROUND: An ampullary tumor, whether malignant or not, must be completely resected.
  • This study aimed to evaluate the outcome of endoscopic papillectomy performed for ampullary tumors at a single center.
  • METHODS: From July 2003 to June 2008, 22 patients with a diagnosis of ampullary tumors determined by endoscopic retrograde cholangiopancreatography (ERCP) were treated using endoscopic resection of the tumors.
  • After the papillectomy, a pathologically incomplete resection was noted in 10 cases, including submucosal invasion of an adenocarcinoma with lateral clean resection margins.
  • [MeSH-major] Adenoma / pathology. Adenoma / surgery. Ampulla of Vater / surgery. Cholangiopancreatography, Endoscopic Retrograde / methods. Common Bile Duct Neoplasms / pathology. Common Bile Duct Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy, Needle. Chi-Square Distribution. Cohort Studies. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Middle Aged. Minimally Invasive Surgical Procedures / adverse effects. Minimally Invasive Surgical Procedures / methods. Neoplasm Staging. Pancreaticoduodenectomy / methods. Postoperative Complications / diagnosis. Postoperative Complications / surgery. Probability. Reoperation / methods. Retrospective Studies. Risk Assessment. Sphincterotomy, Endoscopic / adverse effects. Sphincterotomy, Endoscopic / methods. Survival Rate. Treatment Outcome. Young Adult

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  • (PMID = 19360365.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
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91. Warnecke-Eberz U, Prenzel KL, Baldus SE, Metzger R, Dienes HP, Bollschweiler E, Hoelscher AH, Schneider PM: Significant down-regulation of the plasminogen activator inhibitor 1 mRNA in pancreatic cancer. Pancreas; 2008 Mar;36(2):173-7
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  • OBJECTIVES: We examined mRNA expression of the urokinase-type plasminogen activator (uPA), its receptor (uPAR), and the plasminogen activator inhibitor 1 (PAI-1) in a panel of adenocarcinomas of the pancreas (PC) and cancers of the papilla of Vater (CPV).
  • [MeSH-major] Adenocarcinoma / genetics. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / genetics. Gene Expression Regulation, Neoplastic. Pancreatic Neoplasms / genetics. Plasminogen Activator Inhibitor 1 / genetics. RNA, Messenger / analysis

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  • (PMID = 18376309.001).
  • [ISSN] 1536-4828
  • [Journal-full-title] Pancreas
  • [ISO-abbreviation] Pancreas
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / PLAUR protein, human; 0 / Plasminogen Activator Inhibitor 1; 0 / RNA, Messenger; 0 / Receptors, Cell Surface; 0 / Receptors, Urokinase Plasminogen Activator; 0 / SERPINE1 protein, human; EC 3.4.21.73 / Urokinase-Type Plasminogen Activator
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92. Palanivelu C, Jani K, Senthilnathan P, Parthasarathi R, Rajapandian S, Madhankumar MV: Laparoscopic pancreaticoduodenectomy: technique and outcomes. J Am Coll Surg; 2007 Aug;205(2):222-30
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  • RESULTS: The procedure could be completed laparoscopically with tumor-free margins in all patients, including patients with ampullary carcinoma (n = 24), pancreatic cystadenocarcinoma (n = 4), pancreatic head adenocarcinoma (n = 9), low common bile duct cancer (n = 3), and two patients with chronic pancreatitis with a suspicious mass lesion in the head of pancreas.
  • Five-year actuarial survival rates for all patients with malignancy, ampullary adenocarcinoma, pancreatic cystadenocarcinoma, pancreatic head adenocarcinoma, and common bile duct adenocarcinoma are 32%, 30.7%, 33.3%, 19.1%, and 50%, respectively.

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  • (PMID = 17660068.001).
  • [ISSN] 1072-7515
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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93. Sato Y, Ohwada S, Oyama T, Kashiwabara K, Totsuka O, Yamada T, Morishita Y: Ampullary carcinoma associated with protein-losing gastropathy due to diffuse varioliform gastritis. Hepatogastroenterology; 2005 Jul-Aug;52(64):1143-6
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  • [Title] Ampullary carcinoma associated with protein-losing gastropathy due to diffuse varioliform gastritis.
  • Protein-losing gastropathy due to diffuse varioliform gastritis is a rare condition, and its occurrence accompanying ampullary carcinoma is particularly rare.
  • We report here a case of ampullary carcinoma accompanied with protein-losing gastroenteropathy due to diffuse varioliform gastritis.
  • Upper gastrointestinal endoscopic examination showed diffuse varioliform gastritis and carcinoma of the papilla of Vater.
  • Continuous bleeding from ampullary carcinoma caused anemia and deteriorated hypoproteinemia.
  • Pancreaticoduodenectomy was performed for ampullary carcinoma prior to Helicobacter pylori eradication.
  • The tumor was a papillary adenocarcinoma, which had invaded the lamina muscularis propria over the sphincter of Oddi; the resected stomach revealed typical hyperplastic lymphocytic gastritis. H. pylori were detected on microscopic analysis.
  • [MeSH-major] Adenocarcinoma, Papillary / complications. Ampulla of Vater. Common Bile Duct Neoplasms / complications. Gastritis, Hypertrophic / pathology. Protein-Losing Enteropathies / etiology

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  • (PMID = 16001648.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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94. Chan C, Franssen B, Rubio A, Uscanga L: Pancreaticoduodenectomy in a Latin American country: the transition to a high-volume center. J Gastrointest Surg; 2008 Mar;12(3):527-33
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  • Both ampullary and pancreatic cancer accounted for 34% of cases (42 patients each), 5.7% were distal bile duct and 4% duodenal carcinomas.
  • Mean survival for pancreatic cancer was 22.6 months and ampullary adenocarcinoma was 31.4 months.
  • [MeSH-major] Adenocarcinoma / surgery. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy

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  • (PMID = 17763915.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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95. Park JS, Yoon DS, Park YN, Lee WJ, Chi HS, Kim BR: Transduodenal local resection for low-risk group ampulla of vater carcinoma. J Laparoendosc Adv Surg Tech A; 2007 Dec;17(6):737-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transduodenal local resection for low-risk group ampulla of vater carcinoma.
  • BACKGROUND: Carcinoma of the ampulla of Vater has a more favorable prognosis, compared to other malignant tumors of the periampullary region, because it usually presents with symptoms in the early stage.
  • However, treatment by local resection only of the ampullary carcinoma remains controversial.
  • The aim of this study was to evaluate the treatment results of the ampulla of Vater carcinoma according to different types of operation in low-risk-group patients.
  • METHODS: We retrospectively reviewed the medical records of 17 low-risk-group patients among a total of 102 patients with ampulla of Vater carcinoma who had underwent curative surgery from 1992 to 2002.
  • CONCLUSIONS: Transduodenal local resection is a comparable mode of operation for low-risk-group patients with Ampulla of Vater carcinoma.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Duodenal Neoplasms / surgery. Laparoscopy / methods

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  • (PMID = 18158802.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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96. Niedergethmann M, Dusch N, Widyaningsih R, Weiss C, Kienle P, Post S: Risk-adapted anastomosis for partial pancreaticoduodenectomy reduces the risk of pancreatic fistula: a pilot study. World J Surg; 2010 Jul;34(7):1579-86
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenocarcinoma / surgery. Ampulla of Vater. Anastomosis, Surgical. Bile Duct Neoplasms / surgery. Common Bile Duct Neoplasms / surgery. Gastrostomy. Humans. Pancreatitis, Chronic / surgery. Pilot Projects

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  • (PMID = 20333381.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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97. Chan C, Franssen B, Uscanga L, Robles G, Campuzano M: [Pancreatoduodenectomy: results in a large volume center]. Rev Gastroenterol Mex; 2006 Jul-Sep;71(3):252-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Most frequent diagnosis include ampulary adenocarcinoma and pancreatic cancer Mortality in the entire series was 9.2%, decreased to 2.7% in the 2002-2005 period and from April 2003 has remained in 0.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy

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  • (PMID = 17140045.001).
  • [ISSN] 0375-0906
  • [Journal-full-title] Revista de gastroenterología de México
  • [ISO-abbreviation] Rev Gastroenterol Mex
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
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98. Kawaguchi T, Ochiai T, Ikoma H, Inoue K, Morimura R, Murayama Y, Komatsu S, Shiozaki A, Kuriu Y, Nakanishi M, Ichikawa D, Okamoto K, Fujiwara H, Kokuba Y, Sonoyama T, Otsuji E: Prognostic impact of histological blood vessel invasion in patients with ampullary adenocarcinoma. Hepatogastroenterology; 2010 Nov-Dec;57(104):1347-50
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  • [Title] Prognostic impact of histological blood vessel invasion in patients with ampullary adenocarcinoma.
  • BACKGROUNDS/AIMS: Ampullary adenocarcinoma (AmpCA) has a greater overall survival (OS) rate than other periampullary cancers such as pancreatic cancer or bile duct cancer.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. Common Bile Duct Neoplasms / surgery. Vascular Neoplasms / pathology

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  • (PMID = 21443083.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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99. Akatsu T, Aiura K, Takahashi S, Kameyama K, Kitajima M, Kitagawa Y: Recurrent pancreatitis caused by ampullary carcinoma and minor papilla adenoma in familial polyposis: report of a case. Surg Today; 2008;38(5):440-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent pancreatitis caused by ampullary carcinoma and minor papilla adenoma in familial polyposis: report of a case.
  • Upper endoscopy showed multiple duodenal adenomas including carcinoma involving the papilla of Vater.
  • To remove these duodenal adenomas and ampullary carcinoma and prevent recurrent pancreatitis, we performed pancreaticoduodenectomy.
  • [MeSH-major] Adenocarcinoma / etiology. Adenoma / etiology. Adenomatous Polyposis Coli / complications. Ampulla of Vater. Common Bile Duct Neoplasms / etiology. Pancreatic Neoplasms / etiology. Pancreatitis / etiology


100. Lien HC, Lu YS, Shun CT, Yao YT, Chang WC, Cheng AL: Differential expression of glucocorticoid receptor in carcinomas of the human digestive system. Histopathology; 2008 Feb;52(3):314-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Basosquamous / metabolism. Carcinoma, Squamous Cell / metabolism. Digestive System Neoplasms / metabolism. Receptors, Glucocorticoid / metabolism
  • [MeSH-minor] Ampulla of Vater / metabolism. Ampulla of Vater / pathology. Antineoplastic Combined Chemotherapy Protocols / pharmacology. Bile Ducts, Intrahepatic / metabolism. Bile Ducts, Intrahepatic / pathology. Cell Line, Tumor. Cell Survival / drug effects. Cholangiocarcinoma / metabolism. Cholangiocarcinoma / mortality. Cholangiocarcinoma / pathology. Common Bile Duct Neoplasms / metabolism. Common Bile Duct Neoplasms / mortality. Common Bile Duct Neoplasms / pathology. DNA, Neoplasm / analysis. Dexamethasone / pharmacology. Drug Resistance, Neoplasm / drug effects. Humans. Immunoenzyme Techniques. Sequence Analysis, DNA. Survival Rate

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  • (PMID = 18269582.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Receptors, Glucocorticoid; 7S5I7G3JQL / Dexamethasone
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