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6. Martínez-Román S, Frumovitz M, Deavers MT, Ramirez PT: Metastatic carcinoma of the gallbladder mimicking an advanced cervical carcinoma. Gynecol Oncol; 2005 Jun;97(3):942-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic carcinoma of the gallbladder mimicking an advanced cervical carcinoma.
  • We report a case of metastatic gallbladder carcinoma mimicking a stage IIIB cervical carcinoma.
  • A Pap smear revealed adenocarcinoma, and a biopsy of the endocervical canal was consistent with poorly differentiated adenocarcinoma.
  • A chest CT revealed multiple lesions in both lungs suggestive of metastatic disease, and an abdominal CT revealed a gallbladder tumor with extension into the liver.
  • The patient underwent a CT-guided biopsy of one of the lung lesions and the pathologic findings were consistent with metastatic adenocarcinoma.
  • The patient was diagnosed with stage IVB primary gallbladder adenocarcinoma and was treated with capecitabine, but her condition deteriorated rapidly and she died 5 months later.
  • CONCLUSION: In patients with an atypical presentation for cervical adenocarcinoma, it is important to consider a metastatic tumor in the differential diagnosis and to perform a thorough work-up for metastatic disease before initiating therapy.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Gallbladder Neoplasms / diagnosis. Gallbladder Neoplasms / pathology. Uterine Cervical Neoplasms / diagnosis. Uterine Cervical Neoplasms / secondary


7. Klebe S, Nurminen M, Leigh J, Henderson DW: Diagnosis of epithelial mesothelioma using tree-based regression analysis and a minimal panel of antibodies. Pathology; 2009 Feb;41(2):140-8
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  • AIMS: Immunohistochemistry with panels of antibodies is a standard procedure to distinguish between malignant mesothelioma and metastatic adenocarcinoma.
  • METHODS: Two hundred consecutive cases of pleural malignancy (173 pleural mesotheliomas of epithelial type and 27 cases of secondary adenocarcinoma) were investigated using a standard panel of 12 antibodies (CAM5.2, CK5/6, calretinin, HBME-1, thrombomodulin, WT-1, EMA, CEA, CD15, B72.3, BG8, and TTF-1).
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Antibodies. Immunohistochemistry / methods. Mesothelioma / diagnosis

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  • (PMID = 19152187.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies; 0 / Antigens, CD15; 0 / Biomarkers, Tumor; 0 / Cadherins; 0 / Lewis Blood-Group System; 0 / Lewis Y antigen
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8. Jones RJ, Hawkins RE, Eatock MM, Ferry DR, Eskens FA, Wilke H, Evans TR: A phase II open-label study of DHA-paclitaxel (Taxoprexin) by 2-h intravenous infusion in previously untreated patients with locally advanced or metastatic gastric or oesophageal adenocarcinoma. Cancer Chemother Pharmacol; 2008 Mar;61(3):435-41
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  • [Title] A phase II open-label study of DHA-paclitaxel (Taxoprexin) by 2-h intravenous infusion in previously untreated patients with locally advanced or metastatic gastric or oesophageal adenocarcinoma.
  • PURPOSE: Combination chemotherapy regimens can improve survival in patients with advanced gastric and oesophageal adenocarcinoma.
  • PATIENTS AND METHODS: In this single arm, phase II study of DHA-paclitaxel, eligible patients with previously untreated, inoperable locally advanced or metastatic adenocarcinoma of the oesophagus, oesophago-gastric junction or stomach were treated with DHA-paclitaxel (1,100 mg/m(2)) administered by 2-h intravenous infusion every 21 days.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Agents, Phytogenic / therapeutic use. Esophageal Neoplasms / drug therapy. Paclitaxel / analogs & derivatives. Stomach Neoplasms / drug therapy

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  • (PMID = 17440725.001).
  • [ISSN] 0344-5704
  • [Journal-full-title] Cancer chemotherapy and pharmacology
  • [ISO-abbreviation] Cancer Chemother. Pharmacol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / docosahexaenoyl-paclitaxel; P88XT4IS4D / Paclitaxel
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9. Cho BC, Kim NK, Lim BJ, Kang SO, Sohn JH, Roh JK, Choi ST, Kim SA, Park SE: A carcinoembryonic antigen-secreting adenocarcinoma arising in tailgut cyst: clinical implications of carcinoembryonic antigen. Yonsei Med J; 2005 Aug 31;46(4):555-61
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  • [Title] A carcinoembryonic antigen-secreting adenocarcinoma arising in tailgut cyst: clinical implications of carcinoembryonic antigen.
  • We report herein on an unusual case of a 40-year-old woman with a carcinoembryonic antigen (CEA)-producing adenocarcinoma arising within a TGC who underwent surgical resection and local radiation therapy.
  • Despite the complete resection, metastatic adenocarcinoma developed five months after surgery.
  • CEA-producing adenocarcinoma from a TGC is extremely rare and only two cases, including this case, have been reported in the English medical literature.
  • [MeSH-major] Adenocarcinoma / therapy. Carcinoembryonic Antigen / blood. Cysts / therapy. Hamartoma / therapy. Rectal Neoplasms / therapy

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  • (PMID = 16127782.001).
  • [ISSN] 0513-5796
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen
  • [Number-of-references] 21
  • [Other-IDs] NLM/ PMC2815842
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10. Kripp M, Ströbel P, Dinter D, Lukan N, Hochhaus A, Hofheinz RD: Alpha-fetoprotein expressing metastastic adenocarcinoma of the esophago-gastric junction responding favorably to capecitabine and oxaliplatin. Anticancer Drugs; 2009 Jan;20(1):75-8
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  • [Title] Alpha-fetoprotein expressing metastastic adenocarcinoma of the esophago-gastric junction responding favorably to capecitabine and oxaliplatin.
  • Alpha-fetoprotein-producing metastatic adenocarcinoma of the stomach or the esophago-gastric junction usually exhibits either no or only short-term remission while receiving palliative chemotherapy.
  • We report on a 76-year-old male patient suffering from an unresectable alpha-fetoprotein-producing adenocarcinoma of the esophago-gastric junction with several liver metastases.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Esophageal Neoplasms / drug therapy. Esophagogastric Junction / pathology. Liver Neoplasms / drug therapy. alpha-Fetoproteins / metabolism

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  • (PMID = 19343004.001).
  • [ISSN] 1473-5741
  • [Journal-full-title] Anti-cancer drugs
  • [ISO-abbreviation] Anticancer Drugs
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / AFP protein, human; 0 / alpha-Fetoproteins; 0W860991D6 / Deoxycytidine; U3P01618RT / Fluorouracil; XELOX
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11. Maréchal R, Demols A, Gay F, De Maertelaere V, Arvanitaki M, Hendlisz A, Van Laethem JL: Prognostic factors and prognostic index for chemonaïve and gemcitabine-refractory patients with advanced pancreatic cancer. Oncology; 2007;73(1-2):41-51
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  • RESULTS: Ninety-nine patients (median age 66 years, range 27-87) suffering from pathologically proven unresectable or metastatic adenocarcinoma of the pancreas were reviewed.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antimetabolites, Antineoplastic / therapeutic use. Biomarkers, Tumor / blood. Deoxycytidine / analogs & derivatives. Karnofsky Performance Status. Pancreatic Neoplasms / drug therapy. Weight Loss

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  • [Copyright] (c) 2008 S. Karger AG, Basel
  • (PMID = 18334830.001).
  • [ISSN] 1423-0232
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Albumins; 0 / Antimetabolites, Antineoplastic; 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine; EC 2.6.1.1 / Aspartate Aminotransferases
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12. Al-Batran SE, Hartmann JT, Hofheinz R, Homann N, Rethwisch V, Probst S, Stoehlmacher J, Clemens MR, Mahlberg R, Fritz M, Seipelt G, Sievert M, Pauligk C, Atmaca A, Jäger E: Biweekly fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) for patients with metastatic adenocarcinoma of the stomach or esophagogastric junction: a phase II trial of the Arbeitsgemeinschaft Internistische Onkologie. Ann Oncol; 2008 Nov;19(11):1882-7
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  • [Title] Biweekly fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) for patients with metastatic adenocarcinoma of the stomach or esophagogastric junction: a phase II trial of the Arbeitsgemeinschaft Internistische Onkologie.
  • PATIENTS AND METHODS: Patients with measurable, metastatic adenocarcinoma of the stomach or esophagogastric junction and no prior chemotherapy received oxaliplatin 85 mg/m(2), leucovorin 200 mg/m(2), and fluorouracil 2600 mg/m(2) as a 24-h infusion in combination with docetaxel 50 mg/m(2) (FLOT) on day 1 every 2 weeks.
  • Patients had a median age of 60 years (range 29-76) and most (93%) of them had metastatic disease.

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  • (PMID = 18669868.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 0 / Taxoids; 04ZR38536J / oxaliplatin; 15H5577CQD / docetaxel; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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13. Lavasani L, Zapanta PE, Tanna N, Sadeghi N: Metastasis of prostatic adenocarcinoma to the sphenoid sinus. Ann Otol Rhinol Laryngol; 2006 Sep;115(9):690-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastasis of prostatic adenocarcinoma to the sphenoid sinus.
  • The presentation, diagnosis, and management of prostatic adenocarcinoma metastatic to the sphenoid sinus are reviewed.
  • A 67-year-old man with a history of prostatic adenocarcinoma presented with gradual left visual loss.
  • Operative biopsy of the lesion was significant for adenocarcinoma of the prostate.
  • Furthermore, the pathophysiology and potential routes of metastatic disease should be assessed for these primary neoplasms.
  • Having a high level of suspicion for metastatic disease from specific primary sites will help guide the pathological evaluation.
  • As in this clinical scenario of a patient with a history of prostatic adenocarcinoma, appropriate analysis would entail sending specimens for immunohistochemical staining, such as prostate-specific antigen and prostate-specific acid phosphatase.
  • [MeSH-major] Adenocarcinoma / pathology. Paranasal Sinus Neoplasms / secondary. Prostatic Neoplasms / pathology. Sphenoid Sinus / pathology

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  • (PMID = 17044541.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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4. Somali I, Yersal O, Kilçiksiz S: Infratemporal fossa and maxillary sinus metastases from colorectal cancer: a case report. J BUON; 2006 Jul-Sep;11(3):363-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histology of the mass revealed metastatic adenocarcinoma which was similar with the primary sigmoid carcinoma.
  • Although cranial fossa metastases from colorectal cancer are very rare, the physicians should be aware of this type of metastatic pattern in patients who suffer of toothache, painful mastication or numbness of the lips, especially if decay has not been determined.
  • [MeSH-major] Adenocarcinoma / secondary. Colorectal Neoplasms / pathology. Cranial Fossa, Middle. Maxillary Sinus Neoplasms / secondary. Skull Base Neoplasms / secondary

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  • (PMID = 17309165.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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15. de Almeida Holanda MM, de Andrade EM, da Silva JA: [Intramedullary spinal cord metastasis from thyorid carcioma: case report]. Arq Neuropsiquiatr; 2006 Jun;64(2A):338-41
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  • A partial resection of the medullar tumor was performed and the pathological findings showed an metastatic adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Spinal Cord Neoplasms / secondary. Thyroid Neoplasms / pathology

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  • (PMID = 16791383.001).
  • [ISSN] 0004-282X
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Brazil
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16. Hariharan S, Zhu J, Nadkarni MA, Donahue JE: Metastatic lung cancer in the cerebellopontine angles mimicking bilateral acoustic neuroma. J Clin Neurosci; 2005 Feb;12(2):184-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic lung cancer in the cerebellopontine angles mimicking bilateral acoustic neuroma.
  • However, autopsy showed metastatic adenocarcinoma of the lung.
  • Therefore, metastatic carcinoma to the CPA can mimic bilateral acoustic neuromas; imaging studies alone may be insufficient to diagnose NF-2.
  • [MeSH-major] Adenocarcinoma / secondary. Brain Neoplasms / secondary. Cerebellopontine Angle / pathology. Lung Neoplasms / pathology


17. Uharcek P, Mlyncek M, Durcanský D: Appendiceal adenocarcinoma presenting with bilateral Krukenberg tumors. J Obstet Gynaecol Res; 2007 Apr;33(2):211-4
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  • [Title] Appendiceal adenocarcinoma presenting with bilateral Krukenberg tumors.
  • Primary appendiceal malignancy metastatic to the ovaries is a condition that may mimic advanced stage ovarian cancer.
  • A 52-year-old woman referred to our institution for presumed advanced stage of ovarian cancer was found to have primary appendiceal adenocarcinoma metastatic to ovaries at laparotomy.

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  • (PMID = 17441899.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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18. Zhu W, Michael CW: WT1, monoclonal CEA, TTF1, and CA125 antibodies in the differential diagnosis of lung, breast, and ovarian adenocarcinomas in serous effusions. Diagn Cytopathol; 2007 Jun;35(6):370-5
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  • The distinction between metastatic adenocarcinomas of lung (LAC), breast (BAC), and ovary (OAC) in serous effusions can be very difficult since they all can present as tight cell clusters.
  • The aim of this study is to evaluate the usefulness of WT1, monoclonal CEA (mCEA), TTF1, and CA125 antibodies in the differential diagnosis of metastatic adenocarcinoma from the lung, breast and ovary in serous effusions.
  • Metastatic OACs showed positive immunoreactivity to WT1 in 19/20 (95%) cases, CA125 in 20/20 (100%), and all showed negative reaction for both mCEA (0/20, 0%) and TTF1 (0/20, 0%).
  • Our results demonstrate that the WT1 stain is specific for metastatic carcinoma of ovarian primary, showing a high sensitivity.
  • A positive TTF1 staining supports the diagnosis of metastatic carcinoma originating from lung rather than breast, while a negative TTF1 favors the diagnosis of a breast primary.
  • Immunohistochemical studies with WT1, TTF1, and mCEA antibodies are useful in the differential diagnosis of metastatic adenocarcinomas of lung, breast, and ovary.
  • [MeSH-major] Adenocarcinoma / diagnosis. Antibodies, Monoclonal. CA-125 Antigen / immunology. Carcinoembryonic Antigen / immunology. Nuclear Proteins / immunology. Pleural Effusion, Malignant / diagnosis. Transcription Factors / immunology. WT1 Proteins / immunology

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  • (PMID = 17497661.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / CA-125 Antigen; 0 / Carcinoembryonic Antigen; 0 / Nuclear Proteins; 0 / Transcription Factors; 0 / WT1 Proteins; 0 / thyroid nuclear factor 1
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19. Castellano MC, Massone AR, Idiart JR: Primary pulmonary adenocarcinoma metastatic to the uvea, brain and adrenal gland in a dog. J Vet Med A Physiol Pathol Clin Med; 2006 May;53(4):194-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary pulmonary adenocarcinoma metastatic to the uvea, brain and adrenal gland in a dog.
  • Histologically the primary tumour was diagnosed as pulmonary adenocarcinoma with predominant solid pattern.
  • The metastatic behaviour resembled that occurring in humans.
  • To the authors' knowledge, this is the first report of a pulmonary adenocarcinoma with metastasis to the uvea in a dog.
  • [MeSH-major] Adenocarcinoma / veterinary. Brain Neoplasms / veterinary. Dog Diseases / pathology. Lung Neoplasms / veterinary. Uveal Neoplasms / veterinary

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  • (PMID = 16629953.001).
  • [ISSN] 0931-184X
  • [Journal-full-title] Journal of veterinary medicine. A, Physiology, pathology, clinical medicine
  • [ISO-abbreviation] J Vet Med A Physiol Pathol Clin Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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20. Soepenberg O, de Jonge MJ, Sparreboom A, de Bruin P, Eskens FA, de Heus G, Wanders J, Cheverton P, Ducharme MP, Verweij J: Phase I and pharmacokinetic study of DE-310 in patients with advanced solid tumors. Clin Cancer Res; 2005 Jan 15;11(2 Pt 1):703-11
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  • One patient with metastatic adenocarcinoma of unknown primary achieved a histologically proven complete remission.
  • One confirmed partial remission was observed in a patient with metastatic pancreatic cancer and disease stabilization was noted in 14 additional patients.

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  • (PMID = 15701859.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Clinical Trial; Clinical Trial, Phase I; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / DE-310 cpd; 0 / Topoisomerase I Inhibitors; XT3Z54Z28A / Camptothecin
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21. Alfonso M, Adochiles L, Hendrickson VM, Carver DK, Rodriguez GC, Barnes HJ: Metastatic adenocarcinoma in the lungs of older laying hens. Avian Dis; 2005 Sep;49(3):430-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic adenocarcinoma in the lungs of older laying hens.
  • Grossly visible metastatic tumors in the lungs of a few birds prompted collection of lungs from 228 affected hens for histologic examination.
  • Metastatic adenocarcinomas were identified histologically in the lungs of 42 of the 228 hens (18.4%).
  • Metastatic foci showing expansive or invasive growth were identified.
  • These findings indicate that vascular spread of adenocarcinomas is more common than previously thought in chickens, and the lungs are often involved with metastatic tumors, primarily from the reproductive tract.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / veterinary. Aging / physiology. Chickens. Lung Neoplasms / secondary. Lung Neoplasms / veterinary. Oviposition

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  • (PMID = 16252501.001).
  • [ISSN] 0005-2086
  • [Journal-full-title] Avian diseases
  • [ISO-abbreviation] Avian Dis.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CN / N01 CN005114
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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22. Matsuhashi N, Yamaguchi K, Tamura T, Shimokawa K, Sugiyama Y, Adachi Y: Adenocarcinoma in bladder diverticulum, metastatic from gastric cancer. World J Surg Oncol; 2005 Aug 24;3:55
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  • [Title] Adenocarcinoma in bladder diverticulum, metastatic from gastric cancer.
  • A biopsy of the bladder wall revealed well differentiated tubular adenocarcinoma metastatic from gastric carcinoma.

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  • [Cites] Jpn J Clin Oncol. 1999 Jun;29(6):314-6 [10418562.001]
  • [Cites] Cancer. 1955 Jul-Aug;8(4):741-58 [13240656.001]
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  • (PMID = 16117837.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1208965
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23. Saleh HA, El-Fakharany M, Makki H, Kadhim A, Masood S: Differentiating reactive mesothelial cells from metastatic adenocarcinoma in serous effusions: the utility of immunocytochemical panel in the differential diagnosis. Diagn Cytopathol; 2009 May;37(5):324-32
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  • [Title] Differentiating reactive mesothelial cells from metastatic adenocarcinoma in serous effusions: the utility of immunocytochemical panel in the differential diagnosis.
  • Differentiating reactive mesothelial cells (RMs) from metastatic adenocarcinoma cells (MAC) in serous fluids based on cytomorphologic features alone can be very challenging.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Body Fluids / cytology. Epithelium / pathology

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19191294.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Neoplasm
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24. Ioachimescu OC, Mehta AC: From cystic pulmonary airway malformation, to bronchioloalveolar carcinoma and adenocarcinoma of the lung. Eur Respir J; 2005 Dec;26(6):1181-7
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  • [Title] From cystic pulmonary airway malformation, to bronchioloalveolar carcinoma and adenocarcinoma of the lung.
  • The authors present an unusual case of BAC developed in an area of CPAM, with subsequent progression to metastatic adenocarcinoma (AC).
  • The case also presents the unique features of a long-standing, unaltered natural course of paediatric BAC towards invasive and metastatic AC, illustrating that lack of growth over many years cannot be entirely trusted as a criterion of benignity.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma, Bronchiolo-Alveolar / pathology. Cell Transformation, Neoplastic / pathology. Cystic Adenomatoid Malformation of Lung, Congenital / pathology. Lung Neoplasms / pathology

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  • (PMID = 16319347.001).
  • [ISSN] 0903-1936
  • [Journal-full-title] The European respiratory journal
  • [ISO-abbreviation] Eur. Respir. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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25. Abdelrazeq AS, Lund JN, Leveson SH: Spontaneous regression of peritoneal carcinomatosis from a rectal cancer. Eur J Gastroenterol Hepatol; 2005 Dec;17(12):1421-3
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  • Here, we present the case of a 51-year-old man who underwent a curative resection for an adenocarcinoma of the rectum in 1989.
  • Biopsies from the peritoneal lesions showed features typical of metastatic adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Neoplasm Regression, Spontaneous. Peritoneal Neoplasms / secondary. Rectal Neoplasms / surgery

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  • (PMID = 16292100.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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26. Thobe MN, Gurusamy D, Pathrose P, Waltz SE: The Ron receptor tyrosine kinase positively regulates angiogenic chemokine production in prostate cancer cells. Oncogene; 2010 Jan 14;29(2):214-26
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  • In this study we report that Ron is highly expressed in human prostate adenocarcinoma and metastatic lymph nodes when compared with normal prostate or benign prostate hyperplasia.

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  • (PMID = 19838218.001).
  • [ISSN] 1476-5594
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R21 CA125370; United States / NCI NIH HHS / CA / R01 CA125379-02; United States / NCI NIH HHS / CA / CA-125370; United States / NCI NIH HHS / CA / R01 CA125379; United States / NCI NIH HHS / CA / CA125379-02; United States / NCI NIH HHS / CA / CA125379-01A2; United States / NCI NIH HHS / CA / R01 CA125379-01A2
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Chemokine CXCL1; 0 / Chemokine CXCL5; 0 / Chemokines; 0 / Interleukin-8; 0 / NF-kappa B; EC 2.7.1.- / RON protein; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases
  • [Other-IDs] NLM/ NIHMS145531; NLM/ PMC2806938
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27. Ogren M, Bergqvist D, Wåhlander K, Eriksson H, Sternby NH: Trousseau's syndrome - what is the evidence? A population-based autopsy study. Thromb Haemost; 2006 Mar;95(3):541-5
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  • In comparison with squamous cell lung cancer, patients with pulmonary adenocarcinoma had 1.65 times higher odds for PE (95% CI 1.20-2.29).
  • Adenocarcinoma and metastatic cancer were independently associated with PE risk (OR 1.27; 95% CI 1.16-1.40; p<0.001, and OR 1.10;95% CI 1.01-1.20; p=0.024, respectively) but when controlling for cancer type and spread, pancreatic cancer was still associated with an OR of 2.10 (95% CI 1.71-2.58) of PE (p<0.001).
  • [MeSH-major] Adenocarcinoma / complications. Gallbladder Neoplasms / complications. Pancreatic Neoplasms / complications. Pulmonary Embolism / etiology. Stomach Neoplasms / complications


28. Chang YH, Chuang CK, Ng KF, Liao SK: Urethral metastasis from a colon carcinoma. Urology; 2007 Mar;69(3):575.e1-3
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  • Urethral metastatic adenocarcinoma is rare.
  • We report a case of urethral metastasis from an ascending colonic adenocarcinoma.
  • Urethroscopy showed an exophytic tumor in the urethra, and biopsy revealed adenocarcinoma.
  • The pathologic examination showed moderately differentiated adenocarcinoma of the urethra consistent with the colonic primary.
  • [MeSH-major] Adenocarcinoma / secondary. Colonic Neoplasms / pathology. Urethral Neoplasms / secondary

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  • (PMID = 17382172.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
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29. Bae WK, Shim HJ, Choi YD, Kim JW, Cho SH, Kang HC, Chung IJ: Severe hypothyroidism induced by thyroid metastasis of cholangiocarcinoma. Cancer Res Treat; 2009 Mar;41(1):56-8
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  • Neck CT showed a diffuse, low attenuation thyroid gland, and fine-needle aspiration (FNA) demonstrated metastatic adenocarcinoma.
  • In a patient with malignant disease and a goiter, the possibility of a metastatic tumor involving the thyroid should be seriously considered.
  • Metastatic thyroid cancer and thyroid dysfunction are probably infrequent, but diagnosis is important in the institution of appropriate therapy.

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  • (PMID = 19688074.001).
  • [ISSN] 1598-2998
  • [Journal-full-title] Cancer research and treatment : official journal of Korean Cancer Association
  • [ISO-abbreviation] Cancer Res Treat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2699092
  • [Keywords] NOTNLM ; Cholangiocarcinoma / Hypothyroidism / Thyroid metastasis
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30. Pozzi EC, Altermatt HJ, Rees TD, Bornstein MM: Exophytic mass of the gingiva as the first manifestation of metastatic pulmonary adenocarcinoma. J Periodontol; 2008 Jan;79(1):187-91
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  • [Title] Exophytic mass of the gingiva as the first manifestation of metastatic pulmonary adenocarcinoma.
  • METHODS: The clinicopathologic features of a gingival metastasis originating from lung adenocarcinoma in a female patient are described.
  • Finally, a biopsy of the lungs confirmed a poorly differentiated adenocarcinoma with multiple metastases, including the oral cavity.
  • CONCLUSIONS: An exophytic lesion on the gingiva can be the first sign of metastatic adenocarcinoma to the oral mucosa.
  • [MeSH-major] Adenocarcinoma / secondary. Gingival Neoplasms / secondary. Lung Neoplasms / diagnosis

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  • (PMID = 18166110.001).
  • [ISSN] 0022-3492
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / Keratin-7; 0 / Nuclear Proteins; 0 / Transcription Factors; 0 / thyroid nuclear factor 1
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31. Sarbia M, Fritze F, Geddert H, von Weyhern C, Rosenberg R, Gellert K: Differentiation between pancreaticobiliary and upper gastrointestinal adenocarcinomas: is analysis of cytokeratin 17 expression helpful? Am J Clin Pathol; 2007 Aug;128(2):255-9
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  • Metastatic adenocarcinoma of unknown primary site, eg, to lymph nodes, liver, or lung, may originate from many organs.
  • A high prevalence of cytokeratin (CK)17 expression in pancreaticobiliary adenocarcinoma was reported, and preliminary data indicate infrequent or missing expression in gastric adenocarcinoma.
  • CK17 expression was as follows: pancreatic, 88%; bile duct, 59%; esophageal, 30%; distal gastric, 28%; gastric cardiac, 27%; and colorectal adenocarcinoma, 6%.
  • These differences were statistically significant for all tumor types except in comparisons of esophageal, cardiac, and distal gastric adenocarcinoma.
  • However, in individual cases of adenocarcinoma of unknown primary site, CK17 results alone are insufficient to differentiate the analyzed tumor entities.
  • [MeSH-major] Adenocarcinoma / chemistry. Bile Duct Neoplasms / chemistry. Gastrointestinal Neoplasms / chemistry. Keratin-17 / analysis. Pancreatic Neoplasms / chemistry

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  • (PMID = 17638659.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Keratin-17
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32. Hamada M, Ozaki K, Iwata J, Nishioka Y, Horimi T: A case of rectosigmoid cancer metastasizing to a fistula in ano. Jpn J Clin Oncol; 2005 Nov;35(11):676-9
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  • Pathological diagnosis of the excised fistula revealed well-differentiated adenocarcinoma; identical to the colon tumor.
  • We diagnosed this tumor as metastatic adenocarcinoma from a rectosigmoid cancer.
  • [MeSH-major] Adenocarcinoma / secondary. Anus Neoplasms / secondary. Rectal Fistula / pathology. Rectal Neoplasms / pathology. Sigmoid Neoplasms / pathology

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  • (PMID = 16275674.001).
  • [ISSN] 0368-2811
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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33. Primavera V, Querques G, Guigui B, Turco I, Iaculli C, Russo V, Delle Noci N: [Choroidal metastasis from clinically regressed prostate adenocarcinoma: imaging of a rare case]. J Fr Ophtalmol; 2008 Nov;31(9):877-82
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  • [Title] [Choroidal metastasis from clinically regressed prostate adenocarcinoma: imaging of a rare case].
  • We report a rare case of prostatic adenocarcinoma metastases at the choroids, diagnosed and followed by fluorescein angiography (FA), indocyanine-green angiography (ICGA), and optical coherence tomography (OCT-3 Stratus).
  • The systemic workup, including hematologic analysis and total-body computed tomography (CT), revealed elevated serum prostate-specific antigen (PSA) and alkaline phosphatase, extensive abnormalities of the axial skeleton, and nodular pulmonary shadows; therefore, prostatic adenocarcinoma was suspected.
  • Needle biopsies (prostatic and pulmonary) confirmed adenocarcinoma of the prostate, with metastatic disease.
  • Fluorescein angiography, indocyanine-green angiography, and optical coherence tomography are useful tools in the diagnosis and follow-up of prostatic adenocarcinoma metastatic to the choroid.
  • [MeSH-major] Adenocarcinoma / secondary. Choroid Neoplasms / secondary. Prostatic Neoplasms / pathology

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  • (PMID = 19107059.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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34. Jatoi A, Dakhil SR, Foster NR, Ma C, Rowland KM Jr, Moore DF Jr, Jaslowski AJ, Thomas SP, Hauge MD, Flynn PJ, Stella PJ, Alberts SR: Bortezomib, paclitaxel, and carboplatin as a first-line regimen for patients with metastatic esophageal, gastric, and gastroesophageal cancer: phase II results from the North Central Cancer Treatment Group (N044B). J Thorac Oncol; 2008 May;3(5):516-20
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  • [Title] Bortezomib, paclitaxel, and carboplatin as a first-line regimen for patients with metastatic esophageal, gastric, and gastroesophageal cancer: phase II results from the North Central Cancer Treatment Group (N044B).
  • PURPOSE: This study was undertaken to explore the response rate of a first-line, three-drug regimen that consisted of bortezomib, paclitaxel, and carboplatin in patients with metastatic adenocarcinoma of the esophagus, gastroesophageal junction, or gastric cardia.

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  • (PMID = 18449005.001).
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  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U10 CA035267; United States / NCI NIH HHS / CA / U10 CA037417; United States / NCI NIH HHS / CA / N01 CA035431; United States / NCI NIH HHS / CA / U10 CA035269; United States / NCI NIH HHS / CA / CA-37404; United States / NCI NIH HHS / CA / CA-35431; United States / NCI NIH HHS / CA / CA-35090; United States / NCI NIH HHS / CA / U10 CA060276; United States / NCI NIH HHS / CA / CA-35195; United States / NCI NIH HHS / CA / U10 CA037404; United States / NCI NIH HHS / CA / N01 CA035119; United States / NCI NIH HHS / CA / U10 CA063848; United States / NCI NIH HHS / CA / U10 CA035195; United States / NCI NIH HHS / CA / CA-35103; United States / NCI NIH HHS / CA / CA-25224; United States / NCI NIH HHS / CA / CA-60276; United States / NCI NIH HHS / CA / CA-35113; United States / NCI NIH HHS / CA / U10 CA035113; United States / NCI NIH HHS / CA / P30 CA015083; United States / NCI NIH HHS / CA / CA-52654; United States / NCI NIH HHS / CA / CA-63848; United States / NCI NIH HHS / CA / U10 CA063849; United States / NCI NIH HHS / CA / CA-35119; United States / NCI NIH HHS / CA / U10 CA035431; United States / NCI NIH HHS / CA / U10 CA035119; United States / NCI NIH HHS / CA / CA-37417; United States / NCI NIH HHS / CA / CA-35269; United States / NCI NIH HHS / CA / U10 CA052654; United States / NCI NIH HHS / CA / U10 CA025224; United States / NCI NIH HHS / CA / U10 CA035090; United States / NCI NIH HHS / CA / CA-15083; United States / NCI NIH HHS / CA / CA-35267; United States / NCI NIH HHS / CA / CA-63849; United States / NCI NIH HHS / CA / N01 CA015083; United States / NCI NIH HHS / CA / U10 CA035103
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Boronic Acids; 0 / Pyrazines; 69G8BD63PP / Bortezomib; BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
  • [Other-IDs] NLM/ NIHMS547678; NLM/ PMC3929582
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35. Puppa G, Shozu M, Perin T, Nomura K, Gloghini A, Campagnutta E, Canzonieri V: Small primary adenocarcinoma in adenomyosis with nodal metastasis: a case report. BMC Cancer; 2007;7:103
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  • [Title] Small primary adenocarcinoma in adenomyosis with nodal metastasis: a case report.
  • A few of these glands were transformed into a moderately differentiated adenocarcinoma.
  • The carcinoma was, therefore, considered to be an endometrioid adenocarcinoma arising from adenomyosis.
  • Four months later, an ultrasound scan revealed enlarged pelvic lymph nodes: a cytological diagnosis of metastatic adenocarcinoma was made.
  • CONCLUSION: Adenocarcinoma in adenomyosis may be affected by local hormonal influence and, despite its small size, may metastasize.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Adenomyoma / pathology. Endometrial Neoplasms / pathology. Leiomyoma / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 17584489.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Tumor Suppressor Protein p53; EC 1.14.14.1 / Aromatase; EC 1.14.99.1 / Cyclooxygenase 2
  • [Other-IDs] NLM/ PMC1913924
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36. Dragoumis DM, Tsiftsoglou AP, Sikou AD, Assimaki AS: Axillary lymph node metastases as the sole clinical site of occult breast carcinoma. J Coll Physicians Surg Pak; 2008 Aug;18(8):517-9
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  • Although histology identified a metastatic adenocarcinoma in the lymph nodes, numerous tests failed to detect the primary tumor.

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  • (PMID = 18798593.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 094ZI81Y45 / Tamoxifen
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37. Burtness B, Thomas L, Sipples R, McGurk M, Salikooti S, Christoforou M, Mirto G, Salem R, Sosa J, Kloss R, Rahman Z, Chung G, Lacy J, Murren JR: Phase II trial of weekly docetaxel/irinotecan combination in advanced pancreatic cancer. Cancer J; 2007 Jul-Aug;13(4):257-62
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  • PATIENTS AND METHODS: Patients who had unresectable or metastatic adenocarcinoma of the pancreas, bidimensionally measurable disease, Eastern Cooperative Oncology Group (ECOG) performance status 0-2, and normal bilirubin levels were eligible.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Camptothecin / analogs & derivatives. Pancreatic Neoplasms / drug therapy. Taxoids / administration & dosage

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  • (PMID = 17762761.001).
  • [ISSN] 1528-9117
  • [Journal-full-title] Cancer journal (Sudbury, Mass.)
  • [ISO-abbreviation] Cancer J
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Taxoids; 15H5577CQD / docetaxel; 7673326042 / irinotecan; XT3Z54Z28A / Camptothecin
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38. Jun DW, Lee OY, Park CK, Choi HS, Yoon BC, Lee MH, Lee DH: Cutaneous metastases of pancreatic carcinoma as a first clinical manifestation. Korean J Intern Med; 2005 Sep;20(3):260-3
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  • Histological examination of the right foreman nodule revealed metastatic adenocarcinoma.
  • Clinicians should be aware that metastatic cutaneous lesions could be the initial presenting sign for pancreatic cancer.
  • The immunohistochemical staining for CK 7 and 19 may also be helpful in the diagnosis of metastatic pancreatic adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Neoplasm Metastasis / pathology. Pancreatic Neoplasms / pathology. Skin Neoplasms / secondary

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  • (PMID = 16295788.001).
  • [ISSN] 1226-3303
  • [Journal-full-title] The Korean journal of internal medicine
  • [ISO-abbreviation] Korean J. Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC3891164
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39. Hinchman KF, Wu JJ, Soden CE Jr, Waldman J, Dyson SW: Multicentric reticulohistiocytosis associated with Burkitt lymphoma and adenocarcinoma. Cutis; 2008 Aug;82(2):113-4
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  • [Title] Multicentric reticulohistiocytosis associated with Burkitt lymphoma and adenocarcinoma.
  • We report a case of MRH in a patient with Burkitt lymphoma and metastatic adenocarcinoma of the gastrointestinal tract.
  • [MeSH-minor] Adenocarcinoma / complications. Adult. Burkitt Lymphoma / complications. Diagnosis, Differential. Humans. Intestinal Neoplasms / complications. Male

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  • (PMID = 18792542.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Hanna WC, Ponsky TA, Trachiotis GD, Knoll SM: Colon cancer metastatic to the lung and the thyroid gland. Arch Surg; 2006 Jan;141(1):93-6
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  • [Title] Colon cancer metastatic to the lung and the thyroid gland.
  • Clinically diagnosed metastatic cancer to the thyroid gland is rare.
  • Colon cancer is one of the most common cancers in the United States, with a high propensity to metastasize; 30% to 40% of patients have metastatic disease at the initial diagnosis.
  • We report a case of colonic adenocarcinoma metastatic to the thyroid gland and lung without involvement of the liver.
  • [MeSH-major] Adenocarcinoma / secondary. Colonic Neoplasms / pathology. Lung Neoplasms / secondary. Thyroid Neoplasms / secondary


41. Becerra CR, Verma UN, Tran HT, Tavana D, Williams NS, Frenkel EP: Phase I dose escalation study with irinotecan, capecitabine, epirubicin, and granulocyte colony-stimulating factor support for patients with solid malignancies. Am J Clin Oncol; 2008 Jun;31(3):219-25
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  • This study determined the maximum-tolerated dose (MTD), toxicity, and pharmacokinetics of irinotecan (CPT-11), capecitabine, and epirubicin in patients with metastatic adenocarcinoma of lung, breast, or gastrointestinal tract.
  • METHODS: Eligibility criteria included the following: documented adenocarcinoma of the lung, breast, or gastrointestinal tract, <3 prior chemotherapy regimens, Eastern Cooperative Oncology Group (ECOG) performance status 0 to 2, age > or =18 years, adequate organ function, and signed informed consent.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Breast Neoplasms / drug therapy. Epirubicin / administration & dosage. Gastrointestinal Neoplasms / drug therapy. Lung Neoplasms / drug therapy. Topoisomerase II Inhibitors

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  • (PMID = 18525298.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Topoisomerase II Inhibitors; 0W860991D6 / Deoxycytidine; 143011-72-7 / Granulocyte Colony-Stimulating Factor; 3Z8479ZZ5X / Epirubicin; 6804DJ8Z9U / Capecitabine; 7673326042 / irinotecan; EC 5.99.1.2 / DNA Topoisomerases, Type I; EC 5.99.1.3 / DNA Topoisomerases, Type II; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin
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42. Lam-Himlin DM, Daniels JA, Gayyed MF, Dong J, Maitra A, Pan D, Montgomery EA, Anders RA: The hippo pathway in human upper gastrointestinal dysplasia and carcinoma: a novel oncogenic pathway. Int J Gastrointest Cancer; 2006;37(4):103-9
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  • RESULTS: Compared to nonneoplastic epithelium, there was a significant increase in YAP cytoplasmic and nuclear localization in high-grade dysplastic epithelium and adenocarcinoma of the esophagus.
  • There was also a significant increase in YAP cytoplasmic and nuclear staining of gastric carcinoma and metastatic gastric disease compared to nonneoplastic gastric tissue.
  • CONCLUSIONS: YAP expression in the cytoplasm and nucleus is significantly increased in high-grade dysplasia and adenocarcinoma of the esophagus as well as gastric adenocarcinoma and metastatic gastric disease, suggesting a role for this recently uncovered pathway in esophageal and gastric epithelial tumorigenesis.
  • [MeSH-major] Adenocarcinoma / metabolism. Barrett Esophagus / metabolism. Esophageal Neoplasms / metabolism. Hyperplasia / metabolism. Nuclear Proteins / metabolism. Stomach / metabolism. Stomach Neoplasms / metabolism. Transcription Factors / metabolism

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  • (PMID = 18175224.001).
  • [ISSN] 1537-3649
  • [Journal-full-title] International journal of gastrointestinal cancer
  • [ISO-abbreviation] Int J Gastrointest Cancer
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK067187; United States / NEI NIH HHS / EY / EY015708; United States / NCI NIH HHS / CA / R01CA113669; United States / NIDDK NIH HHS / DK / R21DK072532
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Nuclear Proteins; 0 / Transcription Factors; 0 / YY1AP1 protein, human
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43. Dennis JL, Hvidsten TR, Wit EC, Komorowski J, Bell AK, Downie I, Mooney J, Verbeke C, Bellamy C, Keith WN, Oien KA: Markers of adenocarcinoma characteristic of the site of origin: development of a diagnostic algorithm. Clin Cancer Res; 2005 May 15;11(10):3766-72
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  • [Title] Markers of adenocarcinoma characteristic of the site of origin: development of a diagnostic algorithm.
  • PURPOSE: Patients with metastatic adenocarcinoma of unknown origin are a common clinical problem.
  • The 10 markers and diagnostic algorithm were then tested in a second, independent, set of primary and metastatic tumors and again 88% were correctly classified.
  • CONCLUSIONS: This classification scheme should enable better prediction on biopsy material of the primary site in patients with metastatic adenocarcinoma of unknown origin, leading to improved management and therapy.
  • [MeSH-major] Adenocarcinoma / diagnosis. Biomarkers, Tumor / analysis. Neoplasms, Unknown Primary / diagnosis

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  • (PMID = 15897574.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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44. Yagihashi Y, Okinami T, Fukuzawa S, Kuriki K: [Pericardial effusion due to metastatic prostate cancer: a case report]. Hinyokika Kiyo; 2008 May;54(5):369-72
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  • [Title] [Pericardial effusion due to metastatic prostate cancer: a case report].
  • Cytologic study suggested metastatic adenocarcinoma or malignant mesothelioma.
  • At autopsy, the major finding was poorly differentiated adenocarcinoma of the prostate with metastases to the mediastinum.
  • [MeSH-major] Adenocarcinoma / pathology. Mediastinal Neoplasms / secondary. Pericardial Effusion / etiology. Prostatic Neoplasms / pathology


45. Gill RR, Umeoka S, Mamata H, Tilleman TR, Stanwell P, Woodhams R, Padera RF, Sugarbaker DJ, Hatabu H: Diffusion-weighted MRI of malignant pleural mesothelioma: preliminary assessment of apparent diffusion coefficient in histologic subtypes. AJR Am J Roentgenol; 2010 Aug;195(2):W125-30
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  • SUBJECTS AND METHODS: Sixty-two patients with a known pleural abnormality and clinical findings suggestive of MPM underwent diffusion-weighted 3-T MRI and ADC calculation.
  • The other five patients had pleural thickening (two patients), metastatic adenocarcinoma (one patient), chronic inflammation (one patient), and malignant lymphoma (one patient).

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  • (PMID = 20651171.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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46. Kim HW, Won KS, Kwon KY, Choi BW, Zeon SK: Metastatic colon cancer to the lung with no detectable primary tumor, mimicking advanced primary lung cancer on F-18 FDG PET/CT imaging. Clin Nucl Med; 2010 Mar;35(3):184-6
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  • [Title] Metastatic colon cancer to the lung with no detectable primary tumor, mimicking advanced primary lung cancer on F-18 FDG PET/CT imaging.
  • CT-guided biopsy of the right lung mass revealed metastatic adenocarcinoma from the colon, but a colon cancer lesion was not detected by dynamic abdominal CT and colonoscopy.

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  • (PMID = 20173453.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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47. Kleinberg L, Holth A, Fridman E, Schwartz I, Shih IeM, Davidson B: The diagnostic role of claudins in serous effusions. Am J Clin Pathol; 2007 Jun;127(6):928-37
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  • Ovarian and breast adenocarcinoma were further analyzed for claudin-7 expression.
  • Claudin-1 expression was most frequent in ovarian and cervical or endometrial adenocarcinoma compared with other adenocarcinomas and MMs (P < .001).
  • Claudin-7 expression was higher in ovarian than in breast adenocarcinoma (P < .001).
  • Our data suggest that expression of claudin-3 or claudin-7 is specific for adenocarcinoma and rules out the diagnosis of cells as mesothelial and that absence of claudin-1 expression excludes ovarian carcinoma as the possible origin of metastatic adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Ascitic Fluid / pathology. Biomarkers, Tumor / metabolism. Membrane Proteins / metabolism. Pleural Effusion, Malignant / diagnosis

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  • (PMID = 17509990.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CLDN1 protein, human; 0 / CLDN3 protein, human; 0 / CLDN7 protein, human; 0 / Claudin-1; 0 / Claudin-3; 0 / Claudins; 0 / Membrane Proteins
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48. Agrawal S, Jha MS, Khurana N, Ansari MS, Dubey D, Srivastava A, Kapoor R, Kumar A, Jain M, Mandhani A: Nephron sparing surgery: A single institution experience. Indian J Urol; 2007 Jan;23(1):23-7
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  • The remaining 16 (55.2%) malignant lesions included renal cell carcinoma (15) and metastatic adenocarcinoma (one).

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  • [Cites] J Urol. 2000 Feb;163(2):442-5 [10647650.001]
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  • (PMID = 19675756.001).
  • [ISSN] 0970-1591
  • [Journal-full-title] Indian journal of urology : IJU : journal of the Urological Society of India
  • [ISO-abbreviation] Indian J Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2721489
  • [Keywords] NOTNLM ; Kidney / kidney diseases / nephron sparing surgery
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49. Awasthi A, Gupta N, Srinivasan R, Nijhawan R, Rajwanshi A: Cytopathological spectrum of unusual malignant pleural effusions at a tertiary care centre in north India. Cytopathology; 2007 Feb;18(1):28-32
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  • The remaining 164 cases were positive for malignancy, out of which 38 cases revealed malignancies other than adenocarcinoma.
  • CONCLUSION: Although metastatic adenocarcinoma was the commonest aetiology of malignant pleural effusions, a significant number of unusual causes of malignant pleural effusion were also encountered.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Humans. India. Retrospective Studies

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  • (PMID = 17250600.001).
  • [ISSN] 0956-5507
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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50. Stigliano I, Puricelli L, Filmus J, Sogayar MC, Bal de Kier Joffé E, Peters MG: Glypican-3 regulates migration, adhesion and actin cytoskeleton organization in mammary tumor cells through Wnt signaling modulation. Breast Cancer Res Treat; 2009 Mar;114(2):251-62
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  • Previously, we determined that GPC3 reexpression in the murine mammary adenocarcinoma LM3 cells induced an impairment of their in vivo invasive and metastatic capacities together with a higher susceptibility to in vitro apoptosis.
  • Here we provide new data demonstrating that GPC3 regulates Wnt pathway in the metastatic adenocarcinoma mammary LM3 cell line.
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Animals. Antigens, CD44 / genetics. Antigens, CD44 / metabolism. Cadherins / genetics. Cadherins / metabolism. Female. Fluorescent Antibody Technique. Immunoblotting. Immunoprecipitation. Mice. Mice, Inbred BALB C. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Signal Transduction. Transfection. Tumor Cells, Cultured. Wound Healing. beta Catenin / genetics. beta Catenin / metabolism

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  • (PMID = 18404367.001).
  • [ISSN] 1573-7217
  • [Journal-full-title] Breast cancer research and treatment
  • [ISO-abbreviation] Breast Cancer Res. Treat.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD44; 0 / Cadherins; 0 / Glypicans; 0 / RNA, Messenger; 0 / Wnt Proteins; 0 / beta Catenin
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51. Lee DH, Han JY, Yu SY, Kim HY, Nam BH, Hong EK, Kim HT, Lee JS: The role of gefitinib treatment for Korean never-smokers with advanced or metastatic adenocarcinoma of the lung: a prospective study. J Thorac Oncol; 2006 Nov;1(9):965-71
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  • [Title] The role of gefitinib treatment for Korean never-smokers with advanced or metastatic adenocarcinoma of the lung: a prospective study.
  • PURPOSE: This prospective trial was conducted to evaluate the role of gefitinib in never-smokers with advanced or metastatic adenocarcinoma of the lung.
  • PATIENTS AND METHODS: The main inclusion criteria were stage IIIB/IV adenocarcinoma of the lung and status as a lifetime never-smoker.
  • CONCLUSION: Gefitinib showed very promising antitumor activity and survival outcome in Korean never-smokers with adenocarcinoma of the lung.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / mortality. Lung Neoplasms / drug therapy. Lung Neoplasms / mortality. Neoplasm Invasiveness / pathology. Quinazolines / administration & dosage

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  • (PMID = 17409980.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Quinazolines; S65743JHBS / gefitinib
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52. Castillo C, Buob D, Mortuaire G, Chevalier D, Aubert S, Copin MC, Leroy X: Signet-ring cell adenocarcinoma of sinonasal tract: an immunohistochemical study of the mucins profile. Arch Pathol Lab Med; 2007 Jun;131(6):961-4
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  • [Title] Signet-ring cell adenocarcinoma of sinonasal tract: an immunohistochemical study of the mucins profile.
  • CONTEXT: Adenocarcinomas of the sinonasal tract are classified into 4 categories: salivary-type, intestinal-type, nonintestinal-type, and metastatic.
  • Signet-ring cell carcinoma is the rarest form of intestinal-type adenocarcinoma.
  • Three patients presented an unfavorable evolution and died of metastatic spread.
  • CONCLUSIONS: The mucin profile is similar to the profile described in digestive tract adenocarcinoma.
  • It is not useful to differentiate between metastatic adenocarcinoma and primary intestinal-type sinonasal adenocarcinoma.

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  • (PMID = 17550327.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Mucins; 0 / Tumor Suppressor Protein p53
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53. Frota AC, Bakalian S, Grégoire FJ, Fernandes BF, Burnier MN Jr: Pseudomelanoma in a patient with prostate adenocarcinoma. Can J Ophthalmol; 2007 Apr;42(2):305-6
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  • [Title] Pseudomelanoma in a patient with prostate adenocarcinoma.
  • CASE REPORT: A 72-year-old man referred for evaluation of a uveal melanoma was revealed with primary prostate adenocarcinoma metastatic to the choroid.
  • COMMENTS: Differential diagnosis of choroidal tumours may be difficult but should include both uveal melanoma and metastatic carcinoma to the uvea.

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  • (PMID = 17392857.001).
  • [ISSN] 0008-4182
  • [Journal-full-title] Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
  • [ISO-abbreviation] Can. J. Ophthalmol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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54. Wierzbicka E, Tourani JM, Guillet G: Improvement of psoriasis and cutaneous side-effects during tyrosine kinase inhibitor therapy for renal metastatic adenocarcinoma. A role for epidermal growth factor receptor (EGFR) inhibitors in psoriasis? Br J Dermatol; 2006 Jul;155(1):213-4
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  • [Title] Improvement of psoriasis and cutaneous side-effects during tyrosine kinase inhibitor therapy for renal metastatic adenocarcinoma. A role for epidermal growth factor receptor (EGFR) inhibitors in psoriasis?
  • [MeSH-major] Adenocarcinoma / drug therapy. Kidney Neoplasms / drug therapy. Lung Neoplasms / secondary. Protein Kinase Inhibitors / therapeutic use. Protein-Tyrosine Kinases / antagonists & inhibitors. Psoriasis / drug therapy. Receptor, Epidermal Growth Factor / antagonists & inhibitors


55. Wang JY, Chai CY, Su YC, Soo KM, Huang YS, Huang TJ, Hsieh JS: Cutaneous metastasis from gastric adenocarcinoma: a case report. Kaohsiung J Med Sci; 2005 Jul;21(7):329-32
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  • [Title] Cutaneous metastasis from gastric adenocarcinoma: a case report.
  • Cutaneous metastasis from gastric adenocarcinoma is an infrequent disease entity.
  • Results of a skin biopsy disclosed groups of metastatic adenocarcinoma cells in the dermis and subcutaneous tissue, forming clusters and strands in a desmoplastic stroma.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Skin Neoplasms / secondary. Stomach Neoplasms / pathology

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  • (PMID = 16089312.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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56. Damin DC, Tolfo GC, Rosito MA, Spiro BL, Kliemann LM: Sentinel lymph node in patients with rectal cancer invading the anal canal. Tech Coloproctol; 2010 Jun;14(2):133-9
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  • METHODS: Between January 2005 and April 2008, 15 patients with adenocarcinoma of the rectum with direct invasion of the anal canal and no clinical evidence of inguinal involvement were prospectively enrolled in the study.
  • Four patients (26.7%) had sentinel nodes identified as positive for metastatic adenocarcinoma.
  • Of the 11 patients with negative sentinel nodes, only four (36.4%) also presented metastatic perirectal lymph nodes.
  • CONCLUSIONS: The standardized procedure was highly effective in sampling inguinal sentinel nodes in very low rectal cancers, allowing the detection of subclinical metastatic disease.
  • [MeSH-major] Adenocarcinoma / secondary. Anal Canal. Inguinal Canal. Rectal Neoplasms / pathology. Sentinel Lymph Node Biopsy

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  • (PMID = 20424879.001).
  • [ISSN] 1128-045X
  • [Journal-full-title] Techniques in coloproctology
  • [ISO-abbreviation] Tech Coloproctol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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57. Chen JL, Huang TW, Hsu PS, Chao-Yang, Tsai CS: Cardiac tamponade as the initial manifestation of metastatic adenocarcinoma from the colon: a case report. Heart Surg Forum; 2007;10(4):E329-30
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  • [Title] Cardiac tamponade as the initial manifestation of metastatic adenocarcinoma from the colon: a case report.
  • Metastatic cardiac malignancies mainly come from the lung, breast, and the lymphoreticular system by direct invasion or hematogenous or lymphatic spread.
  • We report an unusual case of malignant pericardial effusion caused by metastatic adenocarcinoma of colon.
  • [MeSH-major] Adenocarcinoma / complications. Cardiac Tamponade / etiology. Colonic Neoplasms / pathology. Heart Neoplasms / complications

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  • (PMID = 17650460.001).
  • [ISSN] 1522-6662
  • [Journal-full-title] The heart surgery forum
  • [ISO-abbreviation] Heart Surg Forum
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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58. Lyons-Boudreaux V, Mody DR, Zhai J, Coffey D: Cytologic malignancy versus benignancy: how useful are the "newer" markers in body fluid cytology? Arch Pathol Lab Med; 2008 Jan;132(1):23-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CONTEXT: Differentiating reactive effusion, malignant mesothelioma, and metastatic adenocarcinoma in body cavity fluids can be challenging.
  • OBJECTIVE: To evaluate the efficacy of 5 immunohistochemical markers in the differential diagnosis of reactive mesothelial proliferation, malignant mesothelioma, and metastatic adenocarcinoma in body cavity fluids.
  • MOC-31 was positive in all cases of adenocarcinoma, whereas all benign effusions and mesotheliomas were negative.
  • All cases of the metastatic adenocarcinoma were negative for calretinin and D2-40.
  • [MeSH-major] Adenocarcinoma. Biomarkers, Tumor / analysis. Body Fluids / chemistry. Epithelium / chemistry. Mesothelioma / chemistry. Pleural Effusion, Malignant / chemistry

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  • (PMID = 18181669.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / S100 Calcium Binding Protein G; 0 / WT1 Proteins; 0 / X-Linked Inhibitor of Apoptosis Protein; 0 / XIAP protein, human; 0 / monoclonal antibody D2-40
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59. Dockery KF, Puri S, Qazi R, Davis D: FDG-PET on the trail of an unsuspected primary malignancy in the breast. Clin Nucl Med; 2008 Mar;33(3):175-80
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  • Prior investigation of lymphedema in the left lower extremity found widespread lymphadenopathy on computed tomography imaging, leading to initial biopsy revealing adenocarcinoma of unknown primary.
  • F-18 fluorodeoxyglucose PET/computed tomography altered management by localizing an F-18 fluorodeoxyglucose avid breast nodule, directing breast biopsy with specific immunohistochemical analysis for breast cancer lineage in metastatic adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / radionuclide imaging. Breast Neoplasms / radiography. Fluorodeoxyglucose F18. Positron-Emission Tomography. Radiopharmaceuticals

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  • (PMID = 18287839.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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60. Oyama IA, Holzberg AS, Terry Grody MH, Maccarone JL: Metastatic colon carcinoma found within an enterocele sac: a case report. Int Urogynecol J Pelvic Floor Dysfunct; 2005 Jan-Feb;16(1):73-4
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  • [Title] Metastatic colon carcinoma found within an enterocele sac: a case report.
  • We present the case of a 77-year-old female with symptomatic pelvic organ prolapse who presented for reconstructive pelvic surgery and was found to have metastatic adenocarcinoma contained within an enterocele sac.
  • [MeSH-major] Adenocarcinoma / pathology. Colonic Neoplasms / pathology. Hernia / pathology. Neoplasm Metastasis

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  • (PMID = 15647967.001).
  • [Journal-full-title] International urogynecology journal and pelvic floor dysfunction
  • [ISO-abbreviation] Int Urogynecol J Pelvic Floor Dysfunct
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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61. Bergmann I, Weiss M, Schaffner T: [Pulmonary microscopic tumor embolism syndrome]. Dtsch Med Wochenschr; 2006 Mar 24;131(12):618-21
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  • INVESTIGATIONS: Investigations revealed an adenocarcinoma of the colon with retroperitoneal, mediastinal and supraclavicular lymph node metastasis and poorly differentiated carcinoma of the prostate with extensive bone metastases.
  • Both autopsies showed extensive metastatic adenocarcinoma with marked angiosis carcinomatosa of the lungs with numerous occlusions of small arteries and arterioles and resulting cor pulmonale.
  • [MeSH-major] Adenocarcinoma / secondary. Colonic Neoplasms / pathology. Lung Neoplasms / secondary. Neoplastic Cells, Circulating / pathology. Prostatic Neoplasms / pathology

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  • (PMID = 16544237.001).
  • [ISSN] 0012-0472
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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62. Hamid B, Harris C, Spiess J: Metastatic adenocarcinoma in the cerebellopontine angle mimicking facial nerve Schwannoma. Am J Clin Oncol; 2007 Oct;30(5):566-7
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  • [Title] Metastatic adenocarcinoma in the cerebellopontine angle mimicking facial nerve Schwannoma.
  • [MeSH-major] Adenocarcinoma / pathology. Cerebellar Neoplasms / pathology. Cerebellopontine Angle / pathology. Facial Nerve Diseases / diagnosis. Neurilemmoma / diagnosis

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  • (PMID = 17921722.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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63. Rawal YB, Blakenship JA, Mincer HH, Parrish ML, Anderson KM: Metastatic adenocarcinoma of the breast presenting as pulpal/periodontal disease. J Tenn Dent Assoc; 2007;87(2):11-3; quiz 14-5
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  • [Title] Metastatic adenocarcinoma of the breast presenting as pulpal/periodontal disease.

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  • (PMID = 17539226.001).
  • [ISSN] 0040-3385
  • [Journal-full-title] The Journal of the Tennessee Dental Association
  • [ISO-abbreviation] J Tenn Dent Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Tesselaar ME, Osanto S: Risk of venous thromboembolism in lung cancer. Curr Opin Pulm Med; 2007 Sep;13(5):362-7
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  • Patients with adenocarcinoma have higher risk of VTE than patients with squamous cell lung carcinoma.
  • Other risk factors are pneumonectomy, metastatic disease, use of specific chemotherapeutic drugs in combination with novel targeted drugs, such as antiangiogenic agents, and elevated prechemotherapy platelet counts.
  • SUMMARY: Risk factors of VTE in lung cancer patients are adenocarcinoma, metastatic disease, pneumonectomy and anticancer therapy including chemotherapy and anti-VEGF targeted drugs.


65. Bannur HB, Mastiholimath RD, Malur PR: Primary mucinous eccrine adenocarcinoma of the scalp: a case report. Acta Cytol; 2009 Nov-Dec;53(6):698-700
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  • [Title] Primary mucinous eccrine adenocarcinoma of the scalp: a case report.
  • Metastatic deposits from undiagnosed visceral and breast adenocarcinoma are virtually indistinguishable microscopically from sweat gland carcinoma and must be considered before a diagnosis of sweat gland carcinoma is made.
  • A diagnosis of mucinous eccrine adenocarcinoma was given.
  • CONCLUSION: Primary mucinous adenocarcinoma of the skin is a rare tumor and mimics metastatic adenocarcinoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Eccrine Glands / pathology. Scalp / pathology

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  • (PMID = 20014562.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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66. Clarke LE, Seykora JT: Primary cutaneous adenomyoepithelioma. J Cutan Pathol; 2007 Aug;34(8):654-7
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  • This rare tumor may mimic malignant lesions including metastatic adenocarcinoma.

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  • (PMID = 17640238.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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67. Guo Q, Tang W, Inagaki Y, Midorikawa Y, Kokudo N, Sugawara Y, Nakata M, Konishi T, Nagawa H, Makuuchi M: Clinical significance of subcellular localization of KL-6 mucin in primary colorectal adenocarcinoma and metastatic tissues. World J Gastroenterol; 2006 Jan 7;12(1):54-9
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  • [Title] Clinical significance of subcellular localization of KL-6 mucin in primary colorectal adenocarcinoma and metastatic tissues.
  • AIM: To assess subcellular localization of KL-6 mucin and its clinicopathological significance in colorectal carcinoma as well as metastatic lymph node and liver tissues.
  • METHODS: Colorectal carcinoma tissues as well as metastatic lymph node and liver tissues were collected from 82 patients who underwent colorectomy or hepatectomy.
  • Positive staining was observed in all metastatic lesions tested as well as in the primary colorectal carcinoma tissues.
  • CONCLUSION: The subcellular staining pattern of KL-6 in colorectal adenocarcinoma may be an important indicator for unfavorable behaviors such as lymph node and liver metastasis, as well as for the prognosis of patients.
  • [MeSH-major] Adenocarcinoma / chemistry. Antigens / analysis. Colorectal Neoplasms / chemistry. Glycoproteins / analysis. Mucins / analysis

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  • (PMID = 16440417.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens; 0 / Antigens, Neoplasm; 0 / Glycoproteins; 0 / MUC1 protein, human; 0 / Mucin-1; 0 / Mucins
  • [Other-IDs] NLM/ PMC4077483
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68. Solari HP, Ventura MP, Cheema DP, Odashiro AN, Burnier MN Jr: Orbital metastasis from breast carcinoma presenting as neurotrophic keratitis. Can J Ophthalmol; 2006 Feb;41(1):93-6
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  • Light microscopy findings suggested the diagnosis of orbital metastatic breast carcinoma that was confirmed by immunohistochemistry.
  • The histopathologic diagnosis was metastatic adenocarcinoma of the breast to the left orbit.

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  • (PMID = 16462881.001).
  • [ISSN] 0008-4182
  • [Journal-full-title] Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
  • [ISO-abbreviation] Can. J. Ophthalmol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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69. Malle D, Valeri RM, Photiou C, Kaplanis K, Andreadis C, Tsavdaridis D, Destouni C: Significance of immunocytochemical expression of E-cadherin, N-cadherin and CD44 in serous effusions using liquid-based cytology. Acta Cytol; 2005 Jan-Feb;49(1):11-6
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  • OBJECTIVE: To assess the diagnostic utility of E-cadherin (E-cad), N-cadherin (N-cad) and CD44 to discriminate adenocarcinoma cells from benign and malignant mesothelial cells in body cavity fluids and to clarify the origin of cancer cells.
  • STUDY DESIGN: A total of 120 ThinPrep (Cytyc Corp., Boxborough, Massachusetts, U.S.A.) cytologic specimens of serous effusions, which included 22 cases of reactive mesothelium, 6 cases of malignant mesothelioma and 92 cases of metastatic adenocarcinoma from various sites, were immunostained for E-cad, N-cad and CD44.
  • RESULTS: Eighty-three of 92 metastatic adenocarcinomas (90.21%) expressed E-cad, while 1 of 6 malignant mesotheliomas and 1 of 22 cases of reactive mesothelium were positive for E-cad.
  • All 6 cases of mesothelioma expressed N-cad, whereas most cases of metastatic adenocarcinomas were negative.
  • CD44 immunoreactivity was seen in 18 of 22 (81.81%) benign effusions and in 21 of 92 (22.82%) metastatic adenocarcinomas.
  • CONCLUSION: The combination of E-cad, N-cad and CD44 appears to be a useful panel for distinguishing metastatic adenocarcinoma, mesothelioma and reactive mesothelium and also for clarifying the exact histogenetic origin of cancer cells.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Breast Neoplasms / diagnosis. Breast Neoplasms / metabolism. Breast Neoplasms / pathology. Cytodiagnosis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Lung Neoplasms / diagnosis. Lung Neoplasms / metabolism. Lung Neoplasms / pathology. Mesothelioma / diagnosis. Mesothelioma / metabolism. Mesothelioma / pathology. Retrospective Studies


70. Benjamin H, Lebanony D, Rosenwald S, Cohen L, Gibori H, Barabash N, Ashkenazi K, Goren E, Meiri E, Morgenstern S, Perelman M, Barshack I, Goren Y, Edmonston TB, Chajut A, Aharonov R, Bentwich Z, Rosenfeld N, Cohen D: A diagnostic assay based on microRNA expression accurately identifies malignant pleural mesothelioma. J Mol Diagn; 2010 Nov;12(6):771-9
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  • In the absence of accurate markers, MPM can be difficult to distinguish from peripheral lung adenocarcinoma and metastatic epithelial cancers.
  • Hsa-miR-193-3p was overexpressed in MPM, while hsa-miR-200c and hsa-miR-192 were overexpressed in peripheral lung adenocarcinoma and carcinomas that frequently metastasize to lung pleura.

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  • (PMID = 20864637.001).
  • [ISSN] 1943-7811
  • [Journal-full-title] The Journal of molecular diagnostics : JMD
  • [ISO-abbreviation] J Mol Diagn
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MicroRNAs
  • [Other-IDs] NLM/ PMC2963911
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71. Kai N, Ishii H, Morinag R, Sonoda H, Oka H, Amemiya Y, Iwata A, Otani S, Umeki K, Sakashita H, Kadota J: [Pulmonary adenocarcinoma with facial nerve palsy as the first sign of onset due to a metastatic temporal bone tumor]. Nihon Kokyuki Gakkai Zasshi; 2009 Apr;47(4):304-7
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  • [Title] [Pulmonary adenocarcinoma with facial nerve palsy as the first sign of onset due to a metastatic temporal bone tumor].
  • A computed tomographic scan of the chest showed a lung mass in the left lower lobe, which was thereafter diagnosed as adenocarcinoma.
  • An immunohistochemical examination of the tissue specimen obtained from the left temporal bone revealed evidence of metastatic adenocarcinoma from the lung.
  • No other metastatic lesions including separate site of bone were seen.
  • This is a very rare case of lung cancer with facial nerve palsy as the first sign of onset due to a metastatic temporal bone tumor.
  • [MeSH-major] Adenocarcinoma / pathology. Facial Paralysis / etiology. Lung Neoplasms / pathology. Skull Neoplasms / secondary. Temporal Bone

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  • (PMID = 19455960.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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72. Kindler HL, Tothy PK, Wolff R, McCormack RA, Abbruzzese JL, Mani S, Wade-Oliver KT, Vokes EE: Phase II trials of dolastatin-10 in advanced pancreaticobiliary cancers. Invest New Drugs; 2005 Oct;23(5):489-93
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  • We conducted 2 parallel phase II trials of dolastatin-10 in patients with advanced hepatobiliary cancers and pancreatic adenocarcinoma.
  • PATIENTS AND METHODS: Eligible patients had histologically-confirmed metastatic pancreatic adenocarcinoma or metastatic, locally advanced or recurrent cancer of the liver, bile duct or gallbladder, and had received no prior chemotherapy for advanced disease.

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  • (PMID = 16133801.001).
  • [ISSN] 0167-6997
  • [Journal-full-title] Investigational new drugs
  • [ISO-abbreviation] Invest New Drugs
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / U01CA63187
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Depsipeptides; 0 / Oligopeptides; 110417-88-4 / dolastatin 10
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73. Stakia P, Lagos P, Gourgiotis S, Tzilalis VD, Aloizos S, Salemis NS: Large mass affecting retroperitoneal great vessels: a rare presentation of a cancer of unknown primary with diagnostic dilemma and challenged surgical intervention. J Gastrointest Cancer; 2009;40(1-2):55-8
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  • They are metastatic solid tumors whose fundamental characteristic is the absence of identifiable site of the primary tumor.
  • A complete resection of the mass was performed while the histological examination revealed a solitary retroperitoneal lymph node categorized as metastatic adenocarcinoma of unknown primary site.
  • Early surgical excision of the metastatic lesion followed by adjuvant combination chemotherapy should be considered for patients with only a single site of malignancy.
  • [MeSH-major] Adenocarcinoma / secondary. Blood Vessels / pathology. Neoplasms, Unknown Primary / pathology. Retroperitoneal Neoplasms / secondary

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  • (PMID = 19513858.001).
  • [ISSN] 1941-6636
  • [Journal-full-title] Journal of gastrointestinal cancer
  • [ISO-abbreviation] J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Tamura M, Dohhba S, Funaki K, Sasaki S, Michiwa Y, Kurosaka Y, Takekawa S, Kiriyama M, Kojima Y, Kita T: [Pulmonary pleomorphic carcinoma; report of 2 cases]. Kyobu Geka; 2006 Jul;59(7):585-9
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  • Biopsy of the bone revealed metastatic adenocarcinoma.
  • Chest CT revealed a tumor in the right hilar region, which was diagnosed as adenocarcinoma by transbronchial lung biopsy.
  • [MeSH-major] Adenocarcinoma / radiography. Carcinoma / radiography. Lung Neoplasms / radiography

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  • (PMID = 16856536.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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75. Tabrizi AD, Kalloger SE, Köbel M, Cipollone J, Roskelley CD, Mehl E, Gilks CB: Primary ovarian mucinous carcinoma of intestinal type: significance of pattern of invasion and immunohistochemical expression profile in a series of 31 cases. Int J Gynecol Pathol; 2010 Mar;29(2):99-107
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  • Primary ovarian mucinous carcinomas of the intestinal type are uncommon and earlier reports have included cases diagnosed according to older, less stringent, criteria (which would now be considered borderline tumors) and variable numbers of cases of metastatic adenocarcinoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / metabolism. Adenocarcinoma, Mucinous / pathology. Ovarian Neoplasms / metabolism. Ovarian Neoplasms / pathology

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  • (PMID = 20173494.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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76. Barreiro TJ, Katzman PJ: Malignant mesothelioma: a case presentation and review. J Am Osteopath Assoc; 2006 Dec;106(12):699-704
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  • The primary distinctions to be made are between reactive and neoplastic mesothelial processes and between malignant mesothelioma and metastatic adenocarcinoma.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Aged. Biopsy. Diagnosis, Differential. Fatal Outcome. Humans. Male. Radiography, Thoracic. Tomography, X-Ray Computed

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  • (PMID = 17242414.001).
  • [ISSN] 0098-6151
  • [Journal-full-title] The Journal of the American Osteopathic Association
  • [ISO-abbreviation] J Am Osteopath Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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77. Compérat E, Zhang F, Perrotin C, Molina T, Magdeleinat P, Marmey B, Régnard JF, Audouin J, Camilleri-Broët S: Variable sensitivity and specificity of TTF-1 antibodies in lung metastatic adenocarcinoma of colorectal origin. Mod Pathol; 2005 Oct;18(10):1371-6
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  • [Title] Variable sensitivity and specificity of TTF-1 antibodies in lung metastatic adenocarcinoma of colorectal origin.
  • Two different clones of antibodies (8G7G1/1 from Dako, SPT24 from Novocastra) raised against TTF-1 were used on 56 lung-metastatic malignant tumors, 41 from colorectal origin.
  • Three of the four positive cases displayed similar nuclear staining in primary and/or other extrathoracic metastatic sites as well as four of 90 (5%) primary colorectal adenocarcinomas, ruling out the role of lung microenvironment.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma / secondary. Antibodies. Colorectal Neoplasms / pathology. Lung Neoplasms / metabolism. Lung Neoplasms / secondary. Nuclear Proteins / immunology. Transcription Factors / immunology

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  • (PMID = 15861215.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / Nuclear Proteins; 0 / Transcription Factors; 0 / thyroid nuclear factor 1
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78. Mocanu L, Cîmpean AM, Raica M: Value of antimesothelioma HBME-1 in the diagnosis of inflammatory and malignant pleural effusions. Rom J Morphol Embryol; 2006;47(4):351-5
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  • The differentiation of mesothelial hyperplasia, malignant epithelial mesothelioma and metastatic adenocarcinoma in cytologic specimens is often difficult.
  • In this study, immunostaining was performed on 30 smears from seven patients with inflammatory pleural effusions, 21 patients with metastatic pleural effusions and two patients with malignant epithelial mesothelioma.
  • Metastatic tumor cells were positive for HBME-1 in seven (33.33%) cases; the staining pattern in metastatic adenocarcinoma cells was thin membrane and focal cytoplasmic.
  • HBME-1 has a moderate sensibility and specificity for mesothelial cells and can be used as part of a panel for differentiation of malignant and reactive mesothelial cells from adenocarcinoma in pleural effusions.

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  • (PMID = 17392981.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / HBME-1 antigen
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79. Barshack I, Meiri E, Rosenwald S, Lebanony D, Bronfeld M, Aviel-Ronen S, Rosenblatt K, Polak-Charcon S, Leizerman I, Ezagouri M, Zepeniuk M, Shabes N, Cohen L, Tabak S, Cohen D, Bentwich Z, Rosenfeld N: Differential diagnosis of hepatocellular carcinoma from metastatic tumors in the liver using microRNA expression. Int J Biochem Cell Biol; 2010 Aug;42(8):1355-62
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  • [Title] Differential diagnosis of hepatocellular carcinoma from metastatic tumors in the liver using microRNA expression.
  • Distinguishing hepatocellular carcinoma from metastatic tumors in the liver is of great practical importance, with significant therapeutic and prognostic implications.
  • This differential diagnosis can be difficult because metastatic cancers in the liver, especially adenocarcinomas, may mimic the morphology and immunoexpression of hepatocellular carcinoma.
  • Biomarkers that are specifically expressed in either hepatocellular carcinoma or metastatic adenocarcinoma can therefore be useful diagnostic tools.
  • Combinations of these microRNAs accurately identified primary hepatocellular carcinoma from metastatic adenocarcinoma in the liver.

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  • [Copyright] Copyright 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 20619223.001).
  • [ISSN] 1878-5875
  • [Journal-full-title] The international journal of biochemistry & cell biology
  • [ISO-abbreviation] Int. J. Biochem. Cell Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / MicroRNAs
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80. Atkins JN, Jacobs SA, Wieand HS, Smith RE, John WJ, Colangelo LH, Vogel VG, Kuebler JP, Cescon TP, Miller BJ, Geyer CE Jr, Wolmark N: Pemetrexed/oxaliplatin for first-line treatment of patients with advanced colorectal cancer: a phase II trial of the National Surgical Adjuvant Breast and Bowel Project Foundation Research Program. Clin Colorectal Cancer; 2005 Sep;5(3):181-7
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  • In this study, these drugs were used in combination as first-line therapy in a group of patients with metastatic colorectal cancer.
  • Eligibility criteria included a diagnosis of untreated metastatic adenocarcinoma of the colon or rectum, measurable disease, Zubrod performance status <or=2, no adjuvant chemotherapy within 6 months, and >or=12 weeks life expectancy.

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  • (PMID = 16197621.001).
  • [ISSN] 1533-0028
  • [Journal-full-title] Clinical colorectal cancer
  • [ISO-abbreviation] Clin Colorectal Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glutamates; 0 / Organoplatinum Compounds; 04Q9AIZ7NO / Pemetrexed; 04ZR38536J / oxaliplatin; 5Z93L87A1R / Guanine
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81. Kulke MH, Wu B, Clark JW, Enzinger PC, Lynch TJ, Vincitore M, Michelini A, Fuchs CS: A phase II study of doxorubicin, cisplatin, and 5-fluorouracil in patients with advanced adenocarcinoma of the stomach or esophagus. Cancer Invest; 2006 Apr-May;24(3):229-34
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  • [Title] A phase II study of doxorubicin, cisplatin, and 5-fluorouracil in patients with advanced adenocarcinoma of the stomach or esophagus.
  • METHODS: Thirty-two patients with metastatic adenocarcinoma of the stomach, gastroesophageal junction, or esophagus were treated with cisplatin 60 mg/m2 and doxorubicin 30 mg/m2 repeated every 21 days, in combination with infusional 5-fluorouracil 200 mg/m2/day (ACF).
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / adverse effects. Esophageal Neoplasms / drug therapy. Stomach Neoplasms / drug therapy

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  • (PMID = 16809148.001).
  • [ISSN] 0735-7907
  • [Journal-full-title] Cancer investigation
  • [ISO-abbreviation] Cancer Invest.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / K23 CA 093401; United States / NHLBI NIH HHS / HL / K30 HL04095
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 80168379AG / Doxorubicin; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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82. Ivan D, Hafeez Diwan A, Prieto VG: Expression of p63 in primary cutaneous adnexal neoplasms and adenocarcinoma metastatic to the skin. Mod Pathol; 2005 Jan;18(1):137-42
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  • [Title] Expression of p63 in primary cutaneous adnexal neoplasms and adenocarcinoma metastatic to the skin.
  • The purpose of this study was to investigate the pattern of p63 expression in cutaneous adnexal neoplasms and to assess its possible value in the differential diagnosis of primary cutaneous neoplasms vs adenocarcinomas metastatic to the skin.
  • Immunohistochemical analysis for p63 was performed on formalin-fixed, paraffin-embedded archival tissue from 20 benign adnexal tumors, 10 malignant adnexal tumors and 14 adenocarcinomas metastatic to the skin.
  • The expression of p63 was evaluated in epidermal cells, skin appendages and metastatic tumor cells. p63 was consistently expressed in the basal and suprabasal cells of epidermis and cutaneous appendages, including the basal/myoepithelial cells of sweat glands.
  • In contrast, none of the metastatic adenocarcinomas to the skin was positive for p63 (P<0.001).
  • Based on our findings, analysis of p63 expression may help in the differential diagnosis of primary vs metastatic cutaneous adenocarcinomas.
  • [MeSH-major] Adenocarcinoma / secondary. Neoplasms, Adnexal and Skin Appendage / pathology. Phosphoproteins / biosynthesis. Skin / pathology. Skin Neoplasms / pathology. Trans-Activators / biosynthesis


83. Agarwal C, Jain M: Utility of fibronectin in immuocytochemial differentiation of reactive mesothelial cells from metastatic malignant cells in serous effusions. Indian J Pathol Microbiol; 2009 Jan-Mar;52(1):25-8
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  • [Title] Utility of fibronectin in immuocytochemial differentiation of reactive mesothelial cells from metastatic malignant cells in serous effusions.
  • This study was designed to assess the utility of fibronectin as a mesothelial cell marker and evaluate its use along with carcinoembryonic antigen (CEA) as a short panel to aid in the differentiation of reactive mesothelial cells from metastatic adenocarcinoma cells in serous effusions.
  • CEA immunostaining was seen in 80% cases of metastatic adenocarcinoma in serous effusions.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Carcinoembryonic Antigen / analysis. Humans. Sensitivity and Specificity

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  • (PMID = 19136774.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Fibronectins
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84. Pugsley D, Bailly G, Gupta R, Wilke D, Wood L: Can Urol Assoc J; 2009 Jun;3(3):E4-E6
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  • [Transliterated title] A case of metastatic adenocarcinoma of the prostate arising in a meningioma.
  • We present the case of a 70-year-old man who had a prostate adenocarcinoma that metastatized to a previously unknown cranial meningioma.

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  • (PMID = 19543455.001).
  • [ISSN] 1911-6470
  • [Journal-full-title] Canadian Urological Association journal = Journal de l'Association des urologues du Canada
  • [ISO-abbreviation] Can Urol Assoc J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
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85. Hussain T, Salamat A, Farooq MA, Hassan F, Hafeez M: Indications for endoscopic ultrasound and diagnosis on fine-needle aspiration and cytology. J Coll Physicians Surg Pak; 2009 Apr;19(4):223-7
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  • These included metastatic adenocarcinoma in 8, lymphoproliferative disorder in 7, metastatic squamous cell carcinoma in 5, small cell carcinoma in 2 and anaplastic in 1.
  • Pancreatic tumours were adenocarcinoma in 16, poorly differentiated in 3 and neuroendocrine in 2.
  • Stomach tumours were found in 11, and included lymphomas 5, GIST 3, carcinoids 2, metastatic choriocarcinoma 1 and adenocarcinoma in 1.
  • CONCLUSION: The main indication of EUS and pathology of mediastinal and celiac nodes were metastatic malignancy and tuberculosis.
  • Pancreatic adenocarcinoma was another common cause for asking EUS.
  • [MeSH-major] Adenocarcinoma / diagnosis. Endosonography / methods. Lymphatic Diseases / diagnosis. Pancreatic Neoplasms / diagnosis. Stomach Neoplasms / diagnosis. Tuberculosis, Lymph Node / diagnosis

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  • (PMID = 19356336.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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91. Kikuchi E, Kinoshita I, Yamazaki K, Itoh T, Shimizu T, Shimizu H, Nishimura M: Epithelioid sarcoma presenting as pulmonary cysts with cancer antigen 125 expression. Respirology; 2006 Nov;11(6):826-9
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  • An initial skin biopsy led to a misdiagnosis of metastatic adenocarcinoma, as tumour cells were positive for cytokeratin, epithelial membrane antigen, carcinoembryonic antigen and cancer antigen 125.
  • These findings suggested that pulmonary cysts, a rare form of pulmonary metastases from soft tissue sarcomas, had developed through a ball-valve effect of metastatic tumour in small airways.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / immunology. Adenocarcinoma / pathology. Adult. Biopsy. Diagnosis, Differential. Female. Humans. Skin / pathology

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  • (PMID = 17052316.001).
  • [ISSN] 1323-7799
  • [Journal-full-title] Respirology (Carlton, Vic.)
  • [ISO-abbreviation] Respirology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / CA-125 Antigen
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92. Jatoi A, Foster NR, Egner JR, Burch PA, Stella PJ, Rubin J, Dakhil SR, Sargent DJ, Murphy BR, Alberts SR: Older versus younger patients with metastatic adenocarcinoma of the esophagus, gastroesophageal junction, and stomach: a pooled analysis of eight consecutive North Central Cancer Treatment Group (NCCTG) trials. Int J Oncol; 2010 Mar;36(3):601-6
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  • [Title] Older versus younger patients with metastatic adenocarcinoma of the esophagus, gastroesophageal junction, and stomach: a pooled analysis of eight consecutive North Central Cancer Treatment Group (NCCTG) trials.
  • Whether elderly patients with metastatic esophageal, gastroesophageal, and gastric cancer do as well with chemotherapy as their younger counterparts was investigated in this pooled analysis.
  • [MeSH-major] Adenocarcinoma / therapy. Esophageal Neoplasms / therapy. Esophagogastric Junction / pathology. Stomach Neoplasms / therapy

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  • (PMID = 20126980.001).
  • [ISSN] 1791-2423
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / U10 CA035267; United States / NCI NIH HHS / CA / U10 CA037417; United States / NCI NIH HHS / CA / K24 CA131099; United States / NCI NIH HHS / CA / N01 CA035431; United States / NCI NIH HHS / CA / U10 CA035269; United States / NCI NIH HHS / CA / CA-37404; United States / NCI NIH HHS / CA / CA-35431; United States / NCI NIH HHS / CA / CA-35090; United States / NCI NIH HHS / CA / U10 CA060276; United States / NCI NIH HHS / CA / CA-35195; United States / NCI NIH HHS / CA / U10 CA037404; United States / NCI NIH HHS / CA / U10 CA180821; United States / NCI NIH HHS / CA / N01 CA035119; United States / NCI NIH HHS / CA / U10 CA063848; United States / NCI NIH HHS / CA / U10 CA035195; United States / NCI NIH HHS / CA / CA-25224; United States / NCI NIH HHS / CA / K24CA131099; United States / NCI NIH HHS / CA / CA-60276; United States / NCI NIH HHS / CA / CA-35113; United States / NCI NIH HHS / CA / U10 CA035113; United States / NCI NIH HHS / CA / P30 CA015083; United States / NCI NIH HHS / CA / CA-52654; United States / NCI NIH HHS / CA / CA-63848; United States / NCI NIH HHS / CA / U10 CA063849; United States / NCI NIH HHS / CA / U10 CA180882; United States / NCI NIH HHS / CA / CA-35119; United States / NCI NIH HHS / CA / U10 CA035431; United States / NCI NIH HHS / CA / U10 CA035119; United States / NCI NIH HHS / CA / CA-3510; United States / NCI NIH HHS / CA / CA-37417; United States / NCI NIH HHS / CA / CA-35269; United States / NCI NIH HHS / CA / U10 CA052654; United States / NCI NIH HHS / CA / U10 CA025224; United States / NCI NIH HHS / CA / U10 CA035090; United States / NCI NIH HHS / CA / CA-15083; United States / NCI NIH HHS / CA / CA-35267; United States / NCI NIH HHS / CA / CA-63849; United States / NCI NIH HHS / CA / N01 CA015083; United States / NCI NIH HHS / CA / U10 CA035103
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Greece
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93. Jain G, Samaiya A, Mohindra N, Patel K: Bone metastases as the initial presentation of carcinoma of gall bladder: a rarity. Indian J Surg; 2009 Feb;71(1):35-7
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  • Investigation showed metastatic adenocarcinoma in the head of humerus and the primary was found in the gall bladder.

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  • (PMID = 23133106.001).
  • [ISSN] 0972-2068
  • [Journal-full-title] The Indian journal of surgery
  • [ISO-abbreviation] Indian J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3452562
  • [Keywords] NOTNLM ; Bone metastases / Carcinoma gall bladder / Chemotherapy
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94. Vemulakonda VM, Lendvay TS, Shnorhavorian M, Joyner BD, Kaplan H, Mitchell ME, Grady RW: Metastatic adenocarcinoma after augmentation gastrocystoplasty. J Urol; 2008 Mar;179(3):1094-6; discussion 1097
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic adenocarcinoma after augmentation gastrocystoplasty.
  • To define better the risk of malignancy associated with gastric augmentation and the appropriate surveillance protocol for these patients, we describe our experience in 2 patients with metastatic adenocarcinoma following gastrocystoplasty.
  • Both patients had metastatic disease at initial presentation.
  • [MeSH-major] Adenocarcinoma / etiology. Stomach Neoplasms / etiology. Urinary Bladder Neoplasms / etiology. Urologic Surgical Procedures / adverse effects

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  • (PMID = 18206936.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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95. Shivaprakash HN, Jayashree K, Girish M: Villous adenoma: a rare tumor of vaginal vault. Indian J Pathol Microbiol; 2008 Apr-Jun;51(2):265-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The significance of this lesion lies in the fact that it has to be distinguished from metastatic adenocarcinoma from other sites.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Adult. Diagnosis, Differential. Female. Humans

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  • (PMID = 18603704.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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96. Kawahara T, Manabe Y, Asazuma A, Aoyama T, Hashimura T: [Hormone refractory prostate carcinoma metastasizes to the penis: a case report]. Hinyokika Kiyo; 2009 Oct;55(10):627-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Several nodules were observed on the glans, and histological examination of the penile tumor biopsy showed metastatic adenocarcinoma of the prostate.
  • [MeSH-major] Adenocarcinoma / pathology. Penile Neoplasms / secondary. Prostatic Neoplasms / pathology

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  • (PMID = 19938335.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Androgen Antagonists
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97. Sharma UK, Rauniyar RK, Adhikary S, Sinha A: Intrathyroid metastasis presenting as a solitary thyroid nodule: an unusual case of clinically silent lung cancer. Kathmandu Univ Med J (KUMJ); 2008 Jan-Mar;6(1):109-11
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  • Fine needle aspiration cytology from the nodule showed features of metastatic adenocarcinoma.
  • Further detail evaluation revealed primary lung adenocarcinoma with secondaries to adrenals, retroperitoneal and bilateral axillary nodes.
  • This report emphasizes this unusual clinical presentation of carcinoma lung with wide spread secondaries; and a solitary thyroid nodule can be a presenting complain of a metastatic disease.
  • [MeSH-major] Adenocarcinoma / secondary. Lung Neoplasms / pathology. Thyroid Neoplasms / secondary. Thyroid Nodule / pathology


98. Garg PK, Khurana N, Hadke NS: Subcutaneous and breast metastasis from asymptomatic gallbladder carcinoma. Hepatobiliary Pancreat Dis Int; 2009 Apr;8(2):209-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Fine needle aspiration cytology (FNAC) of these nodules revealed metastatic adenocarcinoma.
  • CT-guided FNAC from the growth in the gallbladder revealed adenocarcinoma.
  • She was diagnosed as a case of metastatic adenocarcinoma of the gallbladder and palliative combination chemotherapy with gemcitabine and carboplatin was given.
  • Moreover, bilateral multiple metastatic lesions to breast are also very rare.

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  • (PMID = 19357037.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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99. Kosugi S, Mizumachi S, Kitajima A, Igarashi T, Hamada T, Kaya H, Kurihara K, Ogasawara K, Sakata H, Yamamoto M, Nagamine M, Yamazaki H: Prostate cancer with supraclavicular lymphadenopathy and bulky abdominal tumor. Intern Med; 2007;46(14):1135-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Biopsy of left-sided supraclavicular lymph nodes revealed metastatic adenocarcinoma.
  • Biopsy of the prostate disclosed poorly to moderately differentiated adenocarcinoma.
  • [MeSH-major] Abdominal Neoplasms / secondary. Adenocarcinoma / secondary. Prostatic Neoplasms / pathology


100. Savk E, Kolay A, Meteoglu I, Unsal A, Cevikel H, Uslu M, Karaman G, Sendur N, Erdoğdu I: Cutaneous metastatic adenocarcinoma arising from a malignant sacrococcygeal teratoma in an adult. Dermatol Online J; 2008;14(6):3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous metastatic adenocarcinoma arising from a malignant sacrococcygeal teratoma in an adult.
  • We present a patient with cutaneous metastasis caused by an adenocarcinoma arising from a malignant teratoma.
  • Vulvar skin biopsy confirmed a mucinous adenocarcinoma which had derived from this teratoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Neoplasms, Adipose Tissue / secondary. Neoplasms, Second Primary / secondary. Skin Neoplasms / secondary. Teratoma / pathology. Vulvar Neoplasms / secondary






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