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1. Leal RF, Ayrizono Mde L, Coy CS, Callejas-Neto F, Fagundes JJ, Góes JR: [Gastroduodenal polyposis in patients with familiar adenomatous polyposis after rectocolectomy]. Arq Gastroenterol; 2007 Apr-Jun;44(2):133-6
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  • [Title] [Gastroduodenal polyposis in patients with familiar adenomatous polyposis after rectocolectomy].
  • BACKGROUND: The extra colonic manifestations, like upper gastrointestinal tract polyps and duodenal cancer are disorders that affect long-term morbidity and mortality of patients with familial adenomatous polyposis, after rectocolectomy.
  • AIM: To describe the frequency of those disorders in patients with familial adenomatous polyposis and to review efficacy of upper gastrointestinal endoscopic surveillance.
  • METHODS: Between 1984 and 2005, 62 patients with familial adenomatous polyposis after rectocolectomy, were studied retrospectively, by Coloproctology Group, Medical Sciences Faculty, State University of Campinas, SP, Brazil.
  • Two patients (3,8%) had adenomatous duodenal polyps with severe dysplasia, and one (1,9%) had adenocarcinoma of the duodenal papilla.
  • CONCLUSION: The upper gastrointestinal endoscopic surveillance has importance and the aim is to detect as early as possible the occurrence of duodenal adenocarcinoma and upper gastrointestinal polyps with severe dysplasia.
  • [MeSH-major] Adenomatous Polyposis Coli / surgery. Duodenal Neoplasms / diagnosis. Endoscopy, Digestive System. Polyps / diagnosis. Stomach Neoplasms / diagnosis

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  • (PMID = 17962858.001).
  • [ISSN] 0004-2803
  • [Journal-full-title] Arquivos de gastroenterologia
  • [ISO-abbreviation] Arq Gastroenterol
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
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2. Lee SH, Ahn BK, Chang HK, Baek SU: Adenocarcinoma in ileal pouch after proctocolectomy for familial adenomatous polyposis: report of a case. J Korean Med Sci; 2009 Oct;24(5):985-8
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  • [Title] Adenocarcinoma in ileal pouch after proctocolectomy for familial adenomatous polyposis: report of a case.
  • Restorative proctocolectomy with ileal pouch-anal anastomosis is one of the surgical treatments of choice for patients with familial adenomatous polyposis.
  • Although the risk of cancer developing in an ileal pouch is not yet clear, a few cases of adenocarcinoma arising in an ileal pouch have been reported.
  • We report a case of adenocarcinoma in ileal pouch after proctocolectomy with ileal pouch-anal anastomosis.
  • A 56-yr-old woman was diagnosed as having familial adenomatous polyposis.
  • Endoscopic biopsies revealed adenocarcinoma at the ileal pouch.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenomatous Polyposis Coli / surgery. Colonic Pouches / pathology. Colorectal Neoplasms / diagnosis. Proctocolectomy, Restorative

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  • (PMID = 19795007.001).
  • [ISSN] 1598-6357
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2752792
  • [Keywords] NOTNLM ; Adenocarcinoma / Adenomatous Polyposis Coli / Ileal Pouches
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3. Berkhout M, Nagtegaal ID, Cornelissen SJ, Dekkers MM, van de Molengraft FJ, Peters WH, Nagengast FM, van Krieken JH, Jeuken JW: Chromosomal and methylation alterations in sporadic and familial adenomatous polyposis-related duodenal carcinomas. Mod Pathol; 2007 Dec;20(12):1253-62
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  • [Title] Chromosomal and methylation alterations in sporadic and familial adenomatous polyposis-related duodenal carcinomas.
  • Patients with familial adenomatous polyposis (FAP) have a high risk of developing duodenal carcinomas.
  • Hypermethylation was observed in the immunoglobulin superfamily genes member 4 (IGSF4), TIMP metallopeptidase inhibitor 3 (TIMP3), Estrogen receptor 1 (ESR1), adenomatous polyposis coli (APC), H-cadherin (CDH13) and paired box gene 6 (PAX6) genes.
  • [MeSH-major] Adenocarcinoma / genetics. Adenomatous Polyposis Coli / genetics. Chromosome Aberrations. DNA Methylation. Duodenal Neoplasms / genetics


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4. Bougatef K, Krichene A, Marrakchi R, Kourda N, Blondeau Lahely Y, Moussa A, Troudi W, Jileni SB, Najjar T, Soubrier F, Ammar Elgaaied AB: Do we know all there is to know about Familial Adenomatous Polyposis? Gastroenterol Clin Biol; 2007 Dec;31(12):1062-6
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  • [Title] Do we know all there is to know about Familial Adenomatous Polyposis?
  • Familial Adenomatous Polyposis (FAP) and Attenuated FAP (AFAP) are caused by a germline mutation in the Adenomatous polyposis coli (APC) gene.
  • This report describes a Tunisian patient with an attenuated FAP phenotype, presenting seven colon polyps and an adenocarcinoma but no detectable germline mutations in the FAP target genes.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics

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  • (PMID = 18176357.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Codon; 0 / Codon, Terminator; JAC85A2161 / Adenine
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5. Lazzareschi I, Barone G, Mastrangelo S, Furfaro IF, Rando G, Riccardi R: Could APC gene screening be useful in children with hepatoblastoma? Early onset of adenocarcinoma in a child with familial adenomatous polyposis and hepatoblastoma. Tumori; 2009 Nov-Dec;95(6):819-22
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  • [Title] Could APC gene screening be useful in children with hepatoblastoma? Early onset of adenocarcinoma in a child with familial adenomatous polyposis and hepatoblastoma.
  • Familial adenomatous polyposis is an inherited disorder characterized by the development of hundreds of colorectal adenomas during adolescence, which in many cases will transform into colorectal cancer by the fourth decade of life, along with the development of various malignant tumors including hepatoblastoma.
  • We report on a female patient with a de novo interstitial deletion of 5q21.3-q23.3, encompassing the APC gene, associated with adenomatous polyposis and early colorectal cancer, hepatoblastoma, epidermoid cysts, mental retardation, several mild dysmorphic signs and lower limb venous thrombosis.
  • [MeSH-major] Adenocarcinoma / genetics. Adenomatous Polyposis Coli / genetics. Colonic Neoplasms / genetics. Gene Deletion. Genes, APC. Genetic Testing. Hepatoblastoma / genetics. Liver Neoplasms / genetics


6. Zhang MQ, Chen ZM, Wang HL: Immunohistochemical investigation of tumorigenic pathways in small intestinal adenocarcinoma: a comparison with colorectal adenocarcinoma. Mod Pathol; 2006 Apr;19(4):573-80
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  • [Title] Immunohistochemical investigation of tumorigenic pathways in small intestinal adenocarcinoma: a comparison with colorectal adenocarcinoma.
  • Small intestinal adenocarcinoma is an uncommon neoplasm morphologically similar to or indistinguishable from colorectal adenocarcinoma.
  • Although much has been learned about genetic pathways critical to colorectal tumorigenesis, little is known about molecular alterations involved in the development of small intestinal adenocarcinoma.
  • These included adenomatous polyposis coli and beta-catenin involved in the Wnt signaling pathway, and DNA mismatch repair enzymes hMLH1, hMSH2 and hMSH6 involved in the microsatellite instability pathway.
  • The results show that complete loss of adenomatous polyposis coli immunoreactivity, presumably resulting from its gene mutations, was observed in eight of 26 (31%) small intestinal adenocarcinomas and 36 of 51 (71%) colorectal adenocarcinomas (P = 0.0008).
  • [MeSH-major] Adenocarcinoma / pathology. Colorectal Neoplasms / pathology. Intestinal Neoplasms / pathology. Intestine, Small / pathology
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Adenomatous Polyposis Coli Protein / analysis. Carrier Proteins / analysis. Cell Transformation, Neoplastic. DNA-Binding Proteins / analysis. Humans. Immunohistochemistry. Neoplasm Proteins / analysis. Nuclear Proteins / analysis. Retinoblastoma Protein / analysis. Signal Transduction. Tumor Suppressor Protein p53 / analysis. beta Catenin / analysis

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  • (PMID = 16501564.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Adenomatous Polyposis Coli Protein; 0 / Carrier Proteins; 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein; 0 / MLH1 protein, human; 0 / MLH2 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Retinoblastoma Protein; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; 0 / beta Catenin
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7. Brosens LA, van Hattem A, Hylind LM, Iacobuzio-Donahue C, Romans KE, Axilbund J, Cruz-Correa M, Tersmette AC, Offerhaus GJ, Giardiello FM: Risk of colorectal cancer in juvenile polyposis. Gut; 2007 Jul;56(7):965-7
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  • [Title] Risk of colorectal cancer in juvenile polyposis.
  • BACKGROUND: Juvenile polyposis (JP) is an autosomal-dominant syndrome characterised by the development of hamartomatous gastrointestinal polyps and is associated with colorectal cancer.

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  • (PMID = 17303595.001).
  • [ISSN] 0017-5749
  • [Journal-full-title] Gut
  • [ISO-abbreviation] Gut
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA 51085; United States / NCI NIH HHS / CA / CA 53801; United States / NCI NIH HHS / CA / CA 63721; United States / NCI NIH HHS / CA / P50 CA 93-16
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1994351
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8. Qian B, Ke PQ, Wang L, Liu WJ, Li MX: [Expression and methylation of adenomatous polyposis coli gene in endometrioid adenocarcinoma]. Ai Zheng; 2008 Jun;27(6):585-9
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  • [Title] [Expression and methylation of adenomatous polyposis coli gene in endometrioid adenocarcinoma].
  • Adenomatous polyposis coli (APC) gene, a tumor suppressor gene, is expressed in many tissues, and has a certain relationship with ovarian cancer.
  • This study was to observe the expression and DNA methylation of APC gene in endometrioid adenocarcinoma, and explore its correlations to the occurrence and development of this disease.
  • METHODS: The methylation, mRNA and protein expression of APC gene were detected by methylation-specific polymerase chain reaction (PCR), reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry in 30 specimens of normal proliferative endometrium, 30 specimens of atypical hyperplastic endometrium and 60 specimens of endometrioid adenocarcinoma.
  • RESULTS: The methylation rate of APC gene was significantly higher, the positive rates of APC mRNA and protein were significantly lower in endometrioid adenocarcinoma than in atypical hyperplastic endometrium and normal proliferative endometrium (65.0% vs. 33.3% and 23.3%, 33.3% vs. 63.3% and 73.3%, 30.0% vs. 50.0% and 66.7%,P<0.05).
  • CONCLUSION: The expression and DNA methylation of APC gene are certainly related with the occurrence and development of endometrioid adenocarcinoma.
  • [MeSH-major] Adenomatous Polyposis Coli Protein / genetics. Carcinoma, Endometrioid / genetics. DNA Methylation. Endometrial Neoplasms / genetics

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  • (PMID = 18570730.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / RNA, Messenger
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9. Vermeil V, D'Amore L, Ceci F, Dassatti MR, Negro A, Gossetti F, Negro P: [Familial polyposis coli associated with carcinoma of the uterine cervix]. Chir Ital; 2008 May-Jun;60(3):355-9
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  • [Title] [Familial polyposis coli associated with carcinoma of the uterine cervix].
  • Familial polyposis coli is a heterogeneous disease with a broad spectrum of clinical manifestations including not only multiple polyposis of the small bowel, but also multiple primary tumours, such as carcinoma of the ampulla of Vater, subcutaneous tumours, bone tumours, central nervous system tumous and gynaecological malignancies.
  • This report is of two brothers with familial polyposis, each showing peculiar distinctive features.
  • In one case, polyposis was diagnosed during emergency surgery for ileo-colic intussusception.
  • Polyposis coli was identified late in the second patient who showed an evolution towards colonic adenocarcinoma with multiple hepatic metastases.
  • The possible association of familial polyposis and extracolonic malignancies has already been emphasized in the literature.
  • [MeSH-major] Adenomatous Polyposis Coli. Carcinoma in Situ. Neoplasms, Multiple Primary. Uterine Cervical Neoplasms

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  • (PMID = 18709773.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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10. Buecher B, Baert-Desurmont S, Leborgne J, Humeau B, Olschwang S, Frébourg T: Duodenal adenocarcinoma and Mut Y human homologue-associated polyposis. Eur J Gastroenterol Hepatol; 2008 Oct;20(10):1024-7
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  • [Title] Duodenal adenocarcinoma and Mut Y human homologue-associated polyposis.
  • Mut Y human homologue-associated polyposis is a recently described colorectal adenomatous polyposis with an autosomal recessive mode of inheritance.
  • Several extracolonic manifestations have been reported in patients affected by Mut Y human homologue-associated polyposis (MAP).
  • Among these, duodenal polyposis, a highly prevalent manifestation of Adenomatous Polyposis Coli related familial adenomatous polypyposis, is undoubtedly part of the clinical spectrum of the disease.
  • The true association of other clinical manifestations with MAP remains questionable.We report the observation of two patients affected by MAP who developed an adenocarcinoma of the duodenum in the context of duodenal polyposis.
  • These observations emphasize the malignant potential of MAP-associated duodenal polyposis and the need to enroll these patients into an upper gastrointestinal surveillance programme.
  • [MeSH-major] Adenocarcinoma / genetics. Adenomatous Polyposis Coli / genetics. Colorectal Neoplasms / genetics. DNA Glycosylases / genetics. Duodenal Neoplasms / genetics. Mutation, Missense

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  • (PMID = 18787472.001).
  • [ISSN] 1473-5687
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
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11. Adibelli ZH, Yildirim M, Ozan E, Oztekin O, Kucukzeybek B: Fibroadenoma of the breast in a man associated with adenocarcinoma of the rectum and polyposis coli. JBR-BTR; 2010 Jan-Feb;93(1):12-4
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  • [Title] Fibroadenoma of the breast in a man associated with adenocarcinoma of the rectum and polyposis coli.
  • We present herein the first case of a fibroadenoma of the breast in a 68-year-old man with adenocarcinoma of the rectum and polyposis coli.
  • [MeSH-major] Adenocarcinoma / complications. Adenomatous Polyposis Coli / complications. Breast Neoplasms, Male / complications. Fibroadenoma / complications. Rectal Neoplasms / complications

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  • (PMID = 20397428.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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12. Garrean S, Hering J, Saied A, Jani J, Espat NJ: Gastric adenocarcinoma arising from fundic gland polyps in a patient with familial adenomatous polyposis syndrome. Am Surg; 2008 Jan;74(1):79-83
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  • [Title] Gastric adenocarcinoma arising from fundic gland polyps in a patient with familial adenomatous polyposis syndrome.
  • Familial adenomatous polyposis (FAP) is a rare hereditary syndrome characterized by multiple colorectal polyps and early development of colorectal cancer.
  • Herein, we present a case of gastric adenocarcinoma arising from fundic gland polyps in an FAP patient.
  • [MeSH-major] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Adenomatous Polyposis Coli / pathology. Stomach Neoplasms / genetics. Stomach Neoplasms / pathology


13. Goto A, Nakajima J, Hara K, Niki T, Fukayama M: Lung adenocarcinoma associated with familial adenomatous polyposis. Clear cell carcinoma with beta-catenin accumulation accompanied by atypical adenomatous hyperplasia. Virchows Arch; 2005 Jan;446(1):73-7
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  • [Title] Lung adenocarcinoma associated with familial adenomatous polyposis. Clear cell carcinoma with beta-catenin accumulation accompanied by atypical adenomatous hyperplasia.
  • A 46-year-old man presented with a lung tumor 17 years after a subtotal colectomy and 13 years after a partial duodenectomy for familial adenomatous polyposis (FAP).
  • Pathological analysis of the lung tumor demonstrated adenocarcinoma with clear cells and a papillary structure, accompanied by tiny tumorous nodules in the background lung parenchyma.
  • Many of the nodules were multifocal adenocarcinoma; however, some of the nodules demonstrated atypical adenomatous hyperplasia (AAH).
  • This is the first case report of a lung adenocarcinoma accompanied by AAH in a FAP patient.
  • Immunohistochemical and loss of heterozygosity studies revealed unique features of the lesions reflecting a disruption of the adenomatous poliposis coli-beta-catenin pathway.
  • [MeSH-major] Adenocarcinoma / pathology. Adenomatous Polyposis Coli / complications. Cytoskeletal Proteins / metabolism. Lung Neoplasms / pathology. Trans-Activators / metabolism

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  • (PMID = 15660284.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / Cytoskeletal Proteins; 0 / Trans-Activators; 0 / beta Catenin
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14. Prall F, Weirich V, Ostwald C: Phenotypes of invasion in sporadic colorectal carcinomas related to aberrations of the adenomatous polyposis coli (APC ) gene. Histopathology; 2007 Feb;50(3):318-30
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  • [Title] Phenotypes of invasion in sporadic colorectal carcinomas related to aberrations of the adenomatous polyposis coli (APC ) gene.
  • AIMS: To determine whether the dissociation of tumour cells from neoplastic glands in colorectal carcinomas is caused by disruption of the wnt-signalling pathway and whether the adenomatous polyposis coli (APC) protein is implicated in this.
  • [MeSH-major] Adenocarcinoma, Mucinous / genetics. Colorectal Neoplasms / genetics. Genes, APC. Loss of Heterozygosity / genetics. Mutation

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  • (PMID = 17257127.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins; 0 / Wnt Proteins; 0 / beta Catenin
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15. Shinmura K, Suzuki M, Yamada H, Tao H, Goto M, Kamo T, Nagura K, Kageyama S, Kato M, Ogawa S, Maekawa M, Takamochi K, Suzuki K, Nakamura T, Sugimura H: Characterization of adenocarcinoma of the lung in a familial adenomatous polyposis patient. Pathol Int; 2008 Nov;58(11):706-12
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  • [Title] Characterization of adenocarcinoma of the lung in a familial adenomatous polyposis patient.
  • The incidence of several extracolonic tumors, such as duodenal carcinoma, is higher in familial adenomatous polyposis (FAP) patients than in the general population, but there is little information about lung carcinoma in FAP.
  • Pathohistological analysis of the lung tumor demonstrated mixed adenocarcinoma consisting of a papillary adenocarcinoma component and a bronchioloalveolar carcinoma component.
  • The present results suggest that the chromosomal copy number alterations detected on SNP microarray were involved in the carcinogenesis of the adenocarcinoma of the lung in the present FAP patient.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / pathology. Adenocarcinoma, Papillary / pathology. Adenomatous Polyposis Coli / pathology. Lung Neoplasms / pathology


16. Nzegwu MA, Osuagwu CC, Machembarrena JM, Ezeofor S, Picardo NG, Emegakor C, Odiakosa T: Familial adenomatous polyposis complicated with an invasive colo-rectal adenocarcinoma in a 26-year-old Nigerian male - a rare finding. Eur J Cancer Care (Engl); 2007 Mar;16(2):198-200
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  • [Title] Familial adenomatous polyposis complicated with an invasive colo-rectal adenocarcinoma in a 26-year-old Nigerian male - a rare finding.
  • Familial adenomatous polyposis is very rare in our environment.
  • Repeat histology after panproctocolectomy confirmed foci of invasive adenocarcinoma of the colon up to the muscle coat.
  • [MeSH-major] Adenocarcinoma / pathology. Adenomatous Polyposis Coli / pathology. Colonic Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 17371432.001).
  • [ISSN] 0961-5423
  • [Journal-full-title] European journal of cancer care
  • [ISO-abbreviation] Eur J Cancer Care (Engl)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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17. Ruys AT, Alderlieste YA, Gouma DJ, Dekker E, Mathus-Vliegen EM: Jejunal cancer in patients with familial adenomatous polyposis. Clin Gastroenterol Hepatol; 2010 Aug;8(8):731-3
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  • [Title] Jejunal cancer in patients with familial adenomatous polyposis.
  • BACKGROUND & AIMS: Familial adenomatous polyposis (FAP) is an inherited disease affecting approximately 1:10,000 newborns, characterized by the formation of numerous adenomas in the digestive tract.
  • CONCLUSIONS: Jejunal adenomas in FAP patients are reported occasionally and can progress into adenocarcinoma with a poor prognosis.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma / diagnosis. Adenomatous Polyposis Coli / complications. Jejunal Neoplasms / diagnosis

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  • [Copyright] Copyright 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
  • [CommentIn] Clin Gastroenterol Hepatol. 2010 Oct;8(10):904 [20621624.001]
  • (PMID = 20399906.001).
  • [ISSN] 1542-7714
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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18. Bouguen G, Manfredi S, Blayau M, Dugast C, Buecher B, Bonneau D, Siproudhis L, David V, Bretagne JF: Colorectal adenomatous polyposis Associated with MYH mutations: genotype and phenotype characteristics. Dis Colon Rectum; 2007 Oct;50(10):1612-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Colorectal adenomatous polyposis Associated with MYH mutations: genotype and phenotype characteristics.
  • RESULTS: MYH mutations were identified only in the group of patients with attenuated adenomatous polyposis with ten or more adenomatous polyps.
  • Three patients presented with a family history of adenomatous polyposis in siblings, without vertical transmission.
  • Colorectal cancer was associated with polyposis in seven patients.
  • CONCLUSIONS: MYH mutations have been observed in one-third of patients with attenuated polyposis.
  • The phenotype of the disease is similar to attenuated familial adenomatous polyposis.
  • [MeSH-major] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Adenomatous Polyposis Coli / genetics. Adenomatous Polyposis Coli / pathology. DNA Glycosylases / genetics. Mutation / genetics

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  • (PMID = 17674103.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.2.2.- / DNA Glycosylases
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19. Raoof M, Canter RJ, Paty PB: Variable phenotypic expression of identical MYH germline mutations in siblings with attenuated familial adenomatous polyposis. Am Surg; 2007 Dec;73(12):1250-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Variable phenotypic expression of identical MYH germline mutations in siblings with attenuated familial adenomatous polyposis.
  • Germline mutations in the Mutant-Y-homologue (MYH) gene have been linked to an attenuated form of familial adenomatous polyposis in patients who express a wild-type adenomatous polyposis coli gene.
  • We report a case of siblings with identical germline mutations in the MYH gene, one of whom developed a locally advanced colon adenocarcinoma with few other adenomatous lesions, whereas the other had numerous benign colonic polyps.
  • The variable genotype-phenotype manifestations of MYH mutations and the attenuated familial adenomatous polyposis syndrome are discussed.
  • [MeSH-major] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Adenomatous Polyposis Coli / genetics. Adenomatous Polyposis Coli / pathology. DNA Glycosylases / genetics. Germ-Line Mutation / genetics

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  • (PMID = 18186383.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
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20. Lolis ED, Likoudis P, Voiniadis P, Hassiakos D, Samanides L: Synchronous rectal and colon cancer caused by familial polyposis coli during pregnancy. J Obstet Gynaecol Res; 2007 Apr;33(2):199-202
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  • [Title] Synchronous rectal and colon cancer caused by familial polyposis coli during pregnancy.
  • Both cancers occurred as a result of familial polyposis.
  • This is the first case of synchronous rectal and colon cancer caused by familial polyposis during pregnancy reported in the published literature.
  • [MeSH-major] Adenocarcinoma / etiology. Adenomatous Polyposis Coli / complications. Neoplasms, Multiple Primary / etiology. Pregnancy Complications, Neoplastic / etiology. Rectal Neoplasms / etiology

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  • (PMID = 17441896.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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21. Zhang LX, Pan SY, Chen D, Xie EF, Gao L, Shu YQ, Lu ZH, Cheng L, Yang D, Zhang JN: [Effect of adenomatous polyposis coli(APC) promoter methylation on gene transcription in lung cancer cell lines]. Ai Zheng; 2007 Jun;26(6):576-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Effect of adenomatous polyposis coli(APC) promoter methylation on gene transcription in lung cancer cell lines].
  • BACKGROUND & OBJECTIVE: Hypermethylation of CpG islands in adenomatous polyposis coli (APC) gene has been detected in a variety of human tumors, which is involved in the pathogenesis of these tumors.
  • METHODS: The methylation status of APC promoter 1A in lung adenocarcinoma cell line SPCA1, small cell lung cancer cell line NCI-H446, and big cell lung cancer cell line NCI-H460 was detected by methylation-specific polymerase chain reaction (MSP) and microarray methylated cord blood DNA served as positive control, and unmethylated cord blood DNA served as negative control.
  • [MeSH-major] Adenomatous Polyposis Coli Protein / metabolism. DNA Methylation. Genes, APC. Lung Neoplasms / metabolism. Transcription, Genetic
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Azacitidine / analogs & derivatives. Azacitidine / pharmacology. Carcinoma, Large Cell / metabolism. Carcinoma, Large Cell / pathology. Cell Line, Tumor. CpG Islands / genetics. Humans. Promoter Regions, Genetic. Small Cell Lung Carcinoma / metabolism. Small Cell Lung Carcinoma / pathology

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  • (PMID = 17562260.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 776B62CQ27 / decitabine; M801H13NRU / Azacitidine
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22. Pan SY, Xie EF, Shu YQ, Gao L, Zhang LX, Chen D, Chen JB, Zhao WJ, Mu Y, Zhang JN: [Methylation quantification of adenomatous polyposis coli (APC) gene promoter in plasma of lung cancer patients]. Ai Zheng; 2009 Apr;28(4):384-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Methylation quantification of adenomatous polyposis coli (APC) gene promoter in plasma of lung cancer patients].
  • BACKGROUND AND OBJECTIVE: The protein encoded by adenomatous polyposis coli (APC) gene participates in the signaling transduction pathway.
  • [MeSH-major] Adenomatous Polyposis Coli Protein / genetics. DNA Methylation. Genes, APC. Lung Neoplasms / genetics. Promoter Regions, Genetic
  • [MeSH-minor] Adenocarcinoma / blood. Adenocarcinoma / genetics. Adult. Aged. Base Sequence. Carcinoma, Squamous Cell / blood. Carcinoma, Squamous Cell / genetics. DNA, Neoplasm / genetics. Female. Humans. Male. Middle Aged. Molecular Sequence Data. Polymerase Chain Reaction / methods

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  • (PMID = 19622298.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / DNA, Neoplasm
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23. Campos FG, Habr-Gama A, Kiss DR, da Silva EV, Rawet V, Imperiale AR, Perez R, da Silva JH, Sousa AH Jr, Gama-Rodrigues J: Adenocarcinoma after ileoanal anastomosis for familial adenomatous polyposis: review of risk factors and current surveillance apropos of a case. J Gastrointest Surg; 2005 May-Jun;9(5):695-702
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  • [Title] Adenocarcinoma after ileoanal anastomosis for familial adenomatous polyposis: review of risk factors and current surveillance apropos of a case.
  • Restorative proctocolectomy has become the most common surgical option for familial adenomatous polyposis (FAP) patients, based on the premise that it provides good functional results and reduces colorectal cancer risk.
  • Proctologic examination revealed an elevated mass 3 cm from the anal margin, which biopsy determined to be a mucinous adenocarcinoma.
  • Histologic analysis showed a 2.2 cm mucinous adenocarcinoma between the ileal and anal mucosa (T2N0Mx) and multiple tubular microadenomas in the ileal pouch.
  • [MeSH-major] Adenocarcinoma / etiology. Adenomatous Polyposis Coli / surgery. Anastomosis, Surgical / adverse effects. Anus Neoplasms / etiology. Colonic Pouches / adverse effects. Proctocolectomy, Restorative / adverse effects

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  • (PMID = 15862266.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 46
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24. Jerkic S, Rosewich H, Scharf JG, Perske C, Füzesi L, Wilichowski E, Gärtner J: Colorectal cancer in two pre-teenage siblings with familial adenomatous polyposis. Eur J Pediatr; 2005 May;164(5):306-10
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  • [Title] Colorectal cancer in two pre-teenage siblings with familial adenomatous polyposis.
  • Familial adenomatous polyposis (FAP) is an autosomal dominant disorder that characteristically presents with colon cancer in early adult life.
  • The diagnosis of an adenocarcinoma of the colon and further adenomatous polyps with low-grade and high-grade dysplasia was confirmed by histology.
  • CONCLUSION: Children with familial adenomatous polyposis are at risk for colon cancer and emphasise the need for early tumour recognition.
  • Gastrointestinal symptoms in children should be thoroughly evaluated and standard screening for colonic polyposis should be performed in all individuals with a positive family history and/or known mutations in cancer-associated genes, particularly in children who are under 10 years of age.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenomatous Polyposis Coli / diagnosis. Carcinoma / diagnosis. Colorectal Neoplasms / diagnosis. Siblings


25. Barone M, Scavo MP, Papagni S, Piscitelli D, Guido R, Di Lena M, Comelli MC, Di Leo A: ERβ expression in normal, adenomatous and carcinomatous tissues of patients with familial adenomatous polyposis. Scand J Gastroenterol; 2010 Nov;45(11):1320-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] ERβ expression in normal, adenomatous and carcinomatous tissues of patients with familial adenomatous polyposis.
  • OBJECTIVES: The APC gene mutation triggers familial adenomatous polyposis (FAP) and approximately 80% of sporadic colorectal cancers.
  • FAP summarizes the natural history of colorectal cancer because low- and high-grade dysplastic lesions and adenocarcinoma are simultaneously present in the same patients free from individual and environmental variability factors.
  • [MeSH-major] Adenocarcinoma / genetics. Adenomatous Polyposis Coli / genetics. Colon, Descending / metabolism. Colorectal Neoplasms / genetics. DNA, Neoplasm. Estrogen Receptor beta / genetics. Gene Expression Regulation, Neoplastic

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  • (PMID = 20446826.001).
  • [ISSN] 1502-7708
  • [Journal-full-title] Scandinavian journal of gastroenterology
  • [ISO-abbreviation] Scand. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Estrogen Receptor beta
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26. Donnellan KA, Bigler SA, Wein RO: Papillary thyroid carcinoma and familial adenomatous polyposis of the colon. Am J Otolaryngol; 2009 Jan-Feb;30(1):58-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Papillary thyroid carcinoma and familial adenomatous polyposis of the colon.
  • OBJECTIVE: Case report and limited review of the literature on the topic of papillary thyroid carcinoma and familial adenomatous polyposis and its genetic associations.
  • METHODS: A patient with multiple prior surgeries for colonic polyps, abdominal perineal resection for colorectal cancer, and wedge resection for metastatic adenocarcinoma (consistent with rectal primary) presented with a thyroid mass.
  • Pathologic examination revealed the cribriform-morular variant of papillary carcinoma that has been reported in patients with familial adenomatous polyposis.
  • CONCLUSIONS: Cribriform-morular variant of papillary thyroid carcinoma is an uncommon diagnosis known to be associated with familial adenomatous polyposis.
  • [MeSH-major] Adenomatous Polyposis Coli / diagnosis. Carcinoma, Papillary / pathology. Thyroid Neoplasms / diagnosis. Thyroidectomy / methods

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  • (PMID = 19027515.001).
  • [ISSN] 1532-818X
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 17
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27. Sarin S, Bernath A: Turcot syndrome (glioma polyposis): a case report. South Med J; 2008 Dec;101(12):1273-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Turcot syndrome (glioma polyposis): a case report.
  • Turcot's syndrome (glioma-polyposis) is a rare hereditary disorder characterized by association of colonic polyposis with primary tumors of the central nervous system.
  • Based on the genetic mutations, the patients with Turcot's syndrome are classified into adenomatous polyposis coli (APC) group or hereditary non-polyposis colon cancer (HNPCC) group.
  • [MeSH-major] Adenocarcinoma / pathology. Adenomatous Polyposis Coli / pathology. Cerebellar Neoplasms / pathology. Colonic Neoplasms / pathology. Medulloblastoma / pathology. Neoplastic Syndromes, Hereditary / pathology

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  • (PMID = 19005436.001).
  • [ISSN] 1541-8243
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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28. Ramírez-Tapia D, Jalife-Montaño A, Domínguez-Meléndez KE, Vargas-Domínguez A, Ortega-León LH, Rodríguez-Baez A: [Familial adenomatous polyposis: case report of male twins]. Cir Cir; 2008 Mar-Apr;76(2):173-6
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  • [Title] [Familial adenomatous polyposis: case report of male twins].
  • BACKGROUND: One hundred percent of the cases of familial adenomatous polyposis (FAP) will develop carcinoma; therefore, the necessity of diagnosis at an early age with immediate therapy is essential.
  • The second twin was operated on at the age of 33 years and was already a carrier of a well differentiated rectal adenocarcinoma.
  • [MeSH-major] Adenomatous Polyposis Coli. Diseases in Twins

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  • (PMID = 18492441.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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29. Palade R, Tomescu M, Suliman E, Popa D: [Malignancy of familial adenomatous polyposis. Diagnosis and treatment]. Chirurgia (Bucur); 2007 Nov-Dec;102(6):729-34
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  • [Title] [Malignancy of familial adenomatous polyposis. Diagnosis and treatment].
  • Familial adenomatous polyposis with features of malignancy find in a 23 years old patient, whose diagnosis has been established on endoscopical basis.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adenomatous Polyposis Coli / pathology. Adenomatous Polyposis Coli / surgery. Colorectal Neoplasms / pathology. Colorectal Neoplasms / surgery

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  • (PMID = 18323237.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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30. Mackey R, Walsh RM, Chung R, Brown N, Smith A, Church J, Burke C: Pancreas-sparing duodenectomy is effective management for familial adenomatous polyposis. J Gastrointest Surg; 2005 Nov;9(8):1088-93; discussion 1093
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pancreas-sparing duodenectomy is effective management for familial adenomatous polyposis.
  • Duodenal adenocarcinoma remains the leading cause of cancer death in familial adenomatous polyposis patients following colectomy.
  • Pancreas-sparing duodenectomy represents a definitive treatment for advanced duodenal polyposis and can obviate the need for pancreaticoduodenectomy.
  • [MeSH-major] Adenomatous Polyposis Coli / surgery. Duodenal Neoplasms / surgery. Duodenum / surgery. Pancreaticoduodenectomy / methods

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  • (PMID = 16269379.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Murakami Y, Uemura K, Sasaki M, Morifuji M, Hayashidani Y, Sudo T, Sueda T: Duodenal cancer arising from the remaining duodenum after pylorus-preserving pancreatoduodenectomy for ampullary cancer in familial adenomatous polyposis. J Gastrointest Surg; 2005 Mar;9(3):389-92
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  • [Title] Duodenal cancer arising from the remaining duodenum after pylorus-preserving pancreatoduodenectomy for ampullary cancer in familial adenomatous polyposis.
  • We herein report a rare occurrence of duodenal cancer arising from the remaining duodenum after pylorus-preserving pancreatoduodenectomy for ampullary cancer in familial adenomatous polyposis (FAP).
  • During the current admission, the patient was diagnosed with adenocarcinoma in the Vater's ampulla using imaging and pathological examinations.
  • The tumor was a well-differentiated tubular adenocarcinoma and no other polyps were identified in the duodenum by pathological examination.
  • This lesion was completely resected by endoscopic mucosal resection and the resected specimen revealed well-differentiated tubular adenocarcinoma in an adenomatous lesion.
  • [MeSH-major] Adenocarcinoma / surgery. Adenomatous Polyposis Coli / secondary. Common Bile Duct Neoplasms / pathology. Duodenal Neoplasms / secondary. Duodenal Neoplasms / surgery. Pancreaticoduodenectomy / methods

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  • (PMID = 15749602.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Parés D, García-Ruiz A, Biondo S, Blanco I, Llort G, Arriol E, de Oca J, del Río C, Osorio A, Navarro M, Martí-Ragué J, Jaurrieta E: [Current status of follow-up of the upper digestive tract in familial adenomatous polyposis]. Gastroenterol Hepatol; 2006 Jan;29(1):15-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Current status of follow-up of the upper digestive tract in familial adenomatous polyposis].
  • Familiar adenomatous polyposis (FAP) is a hereditary disease characterized by the development of multiple adenomatous polyps in the gastrointestinal tract and colorectal cancer in practically all patients who do not receive appropriate treatment.
  • In the present article, we report a case of a gastric adenocarcinoma detected during the follow-up of a patient diagnosed with FAP, as well as a review of the literature on this subject.
  • [MeSH-major] Adenocarcinoma / etiology. Adenomatous Polyposis Coli / complications. Stomach Neoplasms / etiology

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  • (PMID = 16393625.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 34
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33. de Castro SM, van Eijck CH, Rutten JP, Dejong CH, van Goor H, Busch OR, Gouma DJ: Pancreas-preserving total duodenectomy versus standard pancreatoduodenectomy for patients with familial adenomatous polyposis and polyps in the duodenum. Br J Surg; 2008 Nov;95(11):1380-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pancreas-preserving total duodenectomy versus standard pancreatoduodenectomy for patients with familial adenomatous polyposis and polyps in the duodenum.
  • BACKGROUND: Pancreas-preserving total duodenectomy (PPTD) was introduced as a replacement for pancreatoduodenectomy (PD) for familial adenomatous polyposis (FAP).
  • METHODS: All 26 patients who underwent PPTD for FAP in four centres in the Netherlands between January 2000 and January 2007 were compared with a group of 77 patients who had PD for ampulla of Vater adenocarcinoma at one centre during the same interval.
  • RESULTS: Morbidity rates were similar after PPTD for FAP (16 patients, 62 per cent) and PD for ampulla of Vater adenocarcinoma (44 patients, 57 per cent) (P = 0.694).
  • [MeSH-major] Adenocarcinoma / surgery. Adenomatous Polyposis Coli / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Pancreas / surgery. Pancreaticoduodenectomy / methods

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  • [Copyright] Copyright (c) 2008 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
  • (PMID = 18844249.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] England
  • [Number-of-references] 43
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34. Trna J, Husová L, Oliverius M, Dastych M Jr, Senkyrík M, Príbramská V: [The case of familial adenomatous polyposis and a proposal for the system of dispensarisation]. Vnitr Lek; 2009 Jun;55(6):587-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The case of familial adenomatous polyposis and a proposal for the system of dispensarisation].
  • We present a case of a 46 years old female with familial adenomatous polyposis of the colon.
  • The adenocarcinoma had been treated using all available oncology therapeutic modalities.
  • [MeSH-major] Adenomatous Polyposis Coli / therapy
  • [MeSH-minor] Adenocarcinoma / surgery. Colonic Neoplasms / surgery. Digestive System Surgical Procedures / adverse effects. Female. Humans. Middle Aged. Short Bowel Syndrome / etiology. Short Bowel Syndrome / therapy

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  • (PMID = 19662891.001).
  • [ISSN] 0042-773X
  • [Journal-full-title] Vnitr̆ní lékar̆ství
  • [ISO-abbreviation] Vnitr Lek
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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35. Canter RJ, Kesmodel SB, Heitjan DF, Veeramachaneni NK, Mokadam NA, Drebin JA, Fraker DL: Suppression of beta-catenin by antisense oligomers augments tumor response to isolated limb perfusion in a rodent model of adenomatous polyposis coli-mutant colon cancer. Ann Surg Oncol; 2005 Sep;12(9):733-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Suppression of beta-catenin by antisense oligomers augments tumor response to isolated limb perfusion in a rodent model of adenomatous polyposis coli-mutant colon cancer.
  • METHODS: Adenomatous polyposis coli-mutant human CRC xenografts were implanted into athymic rats.
  • [MeSH-major] Adenocarcinoma / drug therapy. Colonic Neoplasms / drug therapy. Oligodeoxyribonucleotides, Antisense / administration & dosage. beta Catenin / metabolism
  • [MeSH-minor] Adenomatous Polyposis Coli / complications. Adenomatous Polyposis Coli / genetics. Animals. Antineoplastic Agents, Alkylating / administration & dosage. Cell Line, Tumor. Chemotherapy, Cancer, Regional Perfusion / methods. Extremities. Female. Genetic Therapy. Melphalan / administration & dosage. Models, Animal. Rats. Remission Induction

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  • (PMID = 16132380.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / /
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 0 / Oligodeoxyribonucleotides, Antisense; 0 / beta Catenin; Q41OR9510P / Melphalan
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36. Stănciulea O, Preda C, Herlea V, Popa M, Ulmeanu D, Vasilescu C: [Rare indication of cephalic duodenopancreatectomy with total gastrectomy--periampullary carcinoma in moderate form of familial adenomatous polyposis]. Chirurgia (Bucur); 2007 Mar-Apr;102(2):215-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Rare indication of cephalic duodenopancreatectomy with total gastrectomy--periampullary carcinoma in moderate form of familial adenomatous polyposis].
  • We present the case of a 52 years old man, with significant familial history, diagnosed with familial adenomatous polyposis-attenuated form, with no clinical and endoscopic surveillance until 2001 when he was admitted for an upper gastrointestinal haemorrhage episode.
  • The histopathological exam revealed duodenal G2 adenocarcinoma pT3N0, and gastric hyperplastic polyps with no signs of dysplasia.
  • In 2005 was noted a pulmonary nodule, located in the postero-apical segment of upper left lobe, for which left superior lobe resection was performed (the histopathological exam: metastatic adenocarcinoma).
  • The surgical procedure recommended in patients with attenuated form of familial adenomatous polyposis and suspect periampullary lesions is duodenopancreatectomy.
  • [MeSH-major] Adenomatous Polyposis Coli / surgery. Carcinoma / surgery. Duodenal Neoplasms / surgery. Gastrectomy. Neoplasms, Multiple Primary / surgery. Pancreaticoduodenectomy / methods

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  • (PMID = 17615925.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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37. Olry de Labry Lima A, Sordo del Castillo L, García Mochón L, Epstein D, Bermúdez Tamayo C, Villegas Portero R: [An economic assessment of genetic testing for familial adenomatous polyposis]. Rev Esp Enferm Dig; 2008 Aug;100(8):470-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [An economic assessment of genetic testing for familial adenomatous polyposis].
  • OBJECTIVE: To analyze the cost-effectiveness of genetic testing for first-degree relatives of patients with colon cancer to identify mutations in the APC gene (Adenomatous Polyposis Coli).
  • We compared genetic testing for the APC gene, the cause of familial adenomatous polyposis (FAP), which results in colon cancer, versus no genetic testing for said gene.
  • A sensitivity analysis found that genetic testing remains the dominant strategy for a plausible range of costs of the test itself, and for the probability of developing adenocarcinoma.
  • [MeSH-major] Adenomatous Polyposis Coli / economics. Adenomatous Polyposis Coli / genetics. Genetic Testing / economics

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  • (PMID = 18942899.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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38. Jannasch O, Dombrowski F, Lippert H, Meyer F: Rare coincidence of familial adenomatous polyposis and a retroperitoneal fibromyxoid sarcoma: report of a case. Dis Colon Rectum; 2008 Apr;51(4):477-81
Genetic Alliance. consumer health - Familial Polyposis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rare coincidence of familial adenomatous polyposis and a retroperitoneal fibromyxoid sarcoma: report of a case.
  • PURPOSE: Familial adenomatous polyposis is an autosomal-dominant inherited disease with development of as many as thousands of adenomas within colon and rectum.
  • All untreated patients will develop colorectal adenocarcinoma.
  • An association of familial adenomatous polyposis and sarcomas was reported in a few cases only.
  • METHODS: We present the exceptional case of a 24-year-old male with genetically verified familial adenomatous polyposis (deletion of 10 base pairs at position 228-237 of exon 15A).
  • CONCLUSIONS: To our knowledge, this is the first reported case of familial adenomatous polyposis with metachronous retroperitoneal fibromyxoid sarcoma.
  • In addition to more common semimalignant retroperitoneal desmoid tumors in familial adenomatous polyposis patients, a malignant soft-tissue tumor also has to be considered for differential diagnosis.
  • [MeSH-major] Adenomatous Polyposis Coli / complications. Fibrosarcoma / complications. Retroperitoneal Neoplasms / complications

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  • (PMID = 18180996.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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39. Ulaş M, Neşşar G, Bostanoğlu A, Aydoğ G, Kayaalp C, Ozoğul Y, Seven C: Development of two cancers in the same patient after ileorectal and ileal pouch anal anastomosis for familial adenomatous polyposis. Med Princ Pract; 2006;15(1):83-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Development of two cancers in the same patient after ileorectal and ileal pouch anal anastomosis for familial adenomatous polyposis.
  • OBJECTIVE: To report a case of a patient with familial adenomatous polyposis.
  • CLINICAL PRESENTATION AND INTERVENTION: A 36-year-old male patient who suffered from rectal bleeding was treated with colectomy and ileorectal anastomosis for familial adenomatous polyposis (FAP) in 1974.
  • After 19 years, in situ adenocarcinoma was detected in the rectal stump.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Adenomatous Polyposis Coli / surgery. Anal Canal / surgery. Carcinoma, Squamous Cell / diagnosis. Colonic Neoplasms / complications. Ileostomy

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  • (PMID = 16340235.001).
  • [ISSN] 1011-7571
  • [Journal-full-title] Medical principles and practice : international journal of the Kuwait University, Health Science Centre
  • [ISO-abbreviation] Med Princ Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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40. Zare M, Jazii FR, Alivand MR, Nasseri NK, Malekzadeh R, Yazdanbod M: Qualitative analysis of Adenomatous Polyposis Coli promoter: hypermethylation, engagement and effects on survival of patients with esophageal cancer in a high risk region of the world, a potential molecular marker. BMC Cancer; 2009;9:24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Qualitative analysis of Adenomatous Polyposis Coli promoter: hypermethylation, engagement and effects on survival of patients with esophageal cancer in a high risk region of the world, a potential molecular marker.
  • Adenomatous Polyposis Coli (APC) promoter hypermethylation has been shown to be a suitable marker for both serum and solid tumors of adenocarcinoma of esophagus.

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  • (PMID = 19149902.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA Primers; 0 / Genetic Markers
  • [Other-IDs] NLM/ PMC2637891
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41. Zhou JN, Chen SQ, Zhang XM, Zhou X, Zhu M, Feng B, Li JT, Ma GJ, Zhang YY: [A novel APC gene germline mutation in a familial adenomatous polyposis pedigree]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2006 Aug;23(4):388-91
Genetic Alliance. consumer health - Familial Polyposis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A novel APC gene germline mutation in a familial adenomatous polyposis pedigree].
  • OBJECTIVE: To detect the adenomatous polyposis coli (APC) gene germline mutation in the proband and her family members with familial adenomatous polyposis (FAP).
  • This mutation manifested an aggressive form of FAP with early onset of colorectal adenocarcinoma and colonic adenoma.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Adenomatous Polyposis Coli Protein / genetics. Germ-Line Mutation

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  • (PMID = 16883523.001).
  • [ISSN] 1003-9406
  • [Journal-full-title] Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
  • [ISO-abbreviation] Zhonghua Yi Xue Yi Chuan Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein
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42. Akatsu T, Aiura K, Takahashi S, Kameyama K, Kitajima M, Kitagawa Y: Recurrent pancreatitis caused by ampullary carcinoma and minor papilla adenoma in familial polyposis: report of a case. Surg Today; 2008;38(5):440-4
MedlinePlus Health Information. consumer health - Pancreatitis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent pancreatitis caused by ampullary carcinoma and minor papilla adenoma in familial polyposis: report of a case.
  • We report a case of relapsing pancreatitis in familial adenomatous polyposis (FAP) with severe duodenal adenomatosis (Spigelman's stage IV).
  • [MeSH-major] Adenocarcinoma / etiology. Adenoma / etiology. Adenomatous Polyposis Coli / complications. Ampulla of Vater. Common Bile Duct Neoplasms / etiology. Pancreatic Neoplasms / etiology. Pancreatitis / etiology


43. Jasperson KW, Blazer KR, Lowstuter K, Weitzel JN: Working through a diagnostic challenge: colonic polyposis, Amsterdam criteria, and a mismatch repair mutation. Fam Cancer; 2008;7(4):281-5
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Working through a diagnostic challenge: colonic polyposis, Amsterdam criteria, and a mismatch repair mutation.
  • The two most common causes of hereditary colorectal cancer are Lynch syndrome and familial adenomatous polyposis (FAP).
  • The phenotype of Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC), is differentiated in part from FAP by the lack of profuse colonic polyposis.
  • We outline evidence supporting the pathogenicity of the identified hMSH6 mutation (arg772trp) and suggest possible etiologies for the unexplained colonic adenomatous polyposis.

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  • (PMID = 18176851.001).
  • [ISSN] 1389-9600
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / M01 RR000043; United States / NCI NIH HHS / CA / R25 CA085771; United States / NCRR NIH HHS / RR / M01 RR00043; United States / NCI NIH HHS / CA / R25 CA85771
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein
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44. Ault GT, Nunoo-Mensah JW, Johnson L, Vukasin P, Kaiser A, Beart RW Jr: Adenocarcinoma arising in the middle of ileoanal pouches: report of five cases. Dis Colon Rectum; 2009 Mar;52(3):538-41
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  • [Title] Adenocarcinoma arising in the middle of ileoanal pouches: report of five cases.
  • Restorative proctocolectomy with ileal pouch-anal anastomosis with or without mucosectomy has become the procedure of choice in patients with long-standing ulcerative colitis complicated by malignancy or medically refractory disease and for familial polyposis syndrome.
  • We present a recent series of five patients who developed adenocarcinoma in the middle of their ileal pouch including the first case of pouch carcinoma in a patient who underwent pouch formation for ulcerative colitis.
  • [MeSH-major] Adenocarcinoma / etiology. Anus Neoplasms / etiology. Colonic Pouches / adverse effects. Ileal Neoplasms / etiology
  • [MeSH-minor] Adenomatous Polyposis Coli / surgery. Adult. Anastomosis, Surgical / adverse effects. Colitis, Ulcerative / surgery. Colorectal Neoplasms / surgery. Female. Humans. Male. Middle Aged. Proctocolectomy, Restorative

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  • (PMID = 19333060.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. Pervaiz MA, Eppolito A, Schmidt K: Papillary thyroid cancer in a patient with MUTYH-associated polyposis (MAP). Fam Cancer; 2010 Dec;9(4):595-7
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  • [Title] Papillary thyroid cancer in a patient with MUTYH-associated polyposis (MAP).
  • We describe a patient with MUTYH-associated polyposis diagnosed with colon cancer at 33 years of age, as well as gastric polyps at a later age.
  • MUTYH-associated polyposis is an autosomal recessively inherited disease which has clinical overlap with Familial adenomatous polyposis and its attenuated form, in that it is associated with risk of colon cancer at a young age.
  • Extra-intestinal cancers have also been reported in patients with MUTYH-associated polyposis; however the tumor spectrum is still evolving.
  • National Comprehensive Cancer Network guidelines recommend screening for colon, duodenal and gastric polyps in individuals with MUTYH-associated polyposis.
  • These will likely continue to evolve as the MUTYH-associated polyposis tumor spectrum is better understood as a result of future case reports and research.
  • [MeSH-major] Adenocarcinoma, Papillary / genetics. Adenomatous Polyposis Coli / genetics. DNA Glycosylases / genetics. Germ-Line Mutation / genetics. Thyroid Neoplasms / genetics

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  • (PMID = 20625837.001).
  • [ISSN] 1573-7292
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
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46. Zhang YH, Sheng JQ, Geng HG, Wu ZT, Li AQ, Li SR: [Effects of cyclooxygenase-2 and proliferating cell nuclear antigen on the onset and development of familial adenomatous polyposis]. Ai Zheng; 2009 Nov;28(11):1181-5
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  • [Title] [Effects of cyclooxygenase-2 and proliferating cell nuclear antigen on the onset and development of familial adenomatous polyposis].
  • This study was to evaluate the roles and correlation of COX-2 and PCNA in the onset and development of familial adenomatous polyposis (FAP) diseases.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenomatous Polyposis Coli / metabolism. Colorectal Neoplasms / metabolism. Cyclooxygenase 2 / metabolism. Proliferating Cell Nuclear Antigen / metabolism
  • [MeSH-minor] Adenocarcinoma, Mucinous / metabolism. Adolescent. Adult. Female. Humans. Intestinal Mucosa / metabolism. Male. Middle Aged. Young Adult


47. de Ferro SM, Suspiro A, Fidalgo P, Lage P, Rodrigues P, Fragoso S, Vitoriano I, Baltazar C, Albuquerque C, Bettencourt A, Leitão CN: Aggressive phenotype of MYH-associated polyposis with jejunal cancer and intra-abdominal desmoid tumor: report of a case. Dis Colon Rectum; 2009 Apr;52(4):742-5
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  • [Title] Aggressive phenotype of MYH-associated polyposis with jejunal cancer and intra-abdominal desmoid tumor: report of a case.
  • MYH-associated polyposis is an inherited autosomal recessive disease, linked to biallelic germline MYH mutations, which predisposes to the development of multiple colorectal adenomas and cancer.
  • We report the case of a young male patient with an aggressive MYH-associated polyposis phenotype.
  • Based on this report, we believe that screening of the entire small bowel should be recommended in MYH-associated polyposis patients, especially in those with duodenal adenomas.
  • Similar to patients with familial adenomatous polyposis, desmoid tumors also may be part of the clinical spectrum of MYH-associated polyposis and may prove to be a significant clinical problem in patients submitted to prophylactic colectomy.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Colorectal Neoplasms / genetics. Fibromatosis, Aggressive / genetics. Jejunal Neoplasms / genetics. Neoplasms, Multiple Primary / genetics. Peritoneal Neoplasms / genetics
  • [MeSH-minor] Adenocarcinoma / genetics. Adenoma / genetics. Adult. DNA Glycosylases / genetics. Duodenal Neoplasms / genetics. Genetic Predisposition to Disease. Germ-Line Mutation. Humans. Intestinal Neoplasms / genetics. Intestinal Obstruction / etiology. Liver Neoplasms / secondary. Male. Mesentery. Mutation. Phenotype. Syndrome

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  • (PMID = 19404084.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.2.2.- / DNA Glycosylases
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48. Okkels H, Sunde L, Lindorff-Larsen K, Thorlacius-Ussing O, Gandrup P, Lindebjerg J, Stubbeteglbjaerg P, Oestergaard JR, Nielsen FC, Krarup HB: Polyposis and early cancer in a patient with low penetrant mutations in MSH6 and APC: hereditary colorectal cancer as a polygenic trait. Int J Colorectal Dis; 2006 Dec;21(8):847-50
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  • [Title] Polyposis and early cancer in a patient with low penetrant mutations in MSH6 and APC: hereditary colorectal cancer as a polygenic trait.
  • Hereditary non-polyposis colorectal cancer and familial adenomatus polyposis are autosomal dominant diseases accounting for 5-7% of all colorectal cancer cases.
  • [MeSH-major] Adenomatous Polyposis Coli Protein / genetics. Colonic Neoplasms / genetics. DNA-Binding Proteins / genetics. Mutation. Rectal Neoplasms / genetics
  • [MeSH-minor] Adenocarcinoma / genetics. Adenoma / genetics. Adenomatous Polyposis Coli / genetics. Adolescent. Codon, Nonsense. Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. Humans. Male. Multifactorial Inheritance. Mutation, Missense. Pedigree. Phenotype

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  • (PMID = 16525781.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / Codon, Nonsense; 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein
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49. Kim JY, Beart RW, Shibata D: Stability of colon stem cell methylation after neo-adjuvant therapy in a patient with attenuated familial adenomatous polyposis. BMC Gastroenterol; 2005 Jun 07;5:19
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  • [Title] Stability of colon stem cell methylation after neo-adjuvant therapy in a patient with attenuated familial adenomatous polyposis.
  • CASE PRESENTATION: A 22 year-old male with attenuated familial adenomatous polyposis received neo-adjuvant chemotherapy and radiation prior to surgery for rectal adenocarcinoma.

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  • (PMID = 15941485.001).
  • [ISSN] 1471-230X
  • [Journal-full-title] BMC gastroenterology
  • [ISO-abbreviation] BMC Gastroenterol
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / R21 DK061140; United States / NIDDK NIH HHS / DK / DK61140
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1164411
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50. Cai JC, Liu D, Zhang HP, Zhong S, Xia NS: [Promoter methylation of several tumor suppressor genes in human gastric adenocarcinoma]. Zhonghua Yi Xue Za Zhi; 2007 Apr 10;87(14):978-81
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  • [Title] [Promoter methylation of several tumor suppressor genes in human gastric adenocarcinoma].
  • OBJECTIVE: To study the promoter methylation of several tumor suppressor genes in human gastric foveolar epithelia (GFE) of chronic gastritis, adjacent GFE of gastric adenocarcinoma (GAC) and GAC.
  • [MeSH-major] Adenocarcinoma / genetics. DNA Methylation. Genes, Tumor Suppressor. Promoter Regions, Genetic. Stomach Neoplasms / genetics
  • [MeSH-minor] Adaptor Proteins, Signal Transducing / genetics. Adenomatous Polyposis Coli Protein / genetics. Adult. Aged. Aged, 80 and over. Cadherins / genetics. Cadherins / metabolism. DNA Modification Methylases / genetics. DNA Repair Enzymes / genetics. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Nuclear Proteins / genetics. Polymerase Chain Reaction / methods. Tumor Suppressor Proteins / genetics

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  • (PMID = 17650424.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Adenomatous Polyposis Coli Protein; 0 / Cadherins; 0 / MLH1 protein, human; 0 / Nuclear Proteins; 0 / Tumor Suppressor Proteins; EC 2.1.1.- / DNA Modification Methylases; EC 2.1.1.63 / MGMT protein, human; EC 6.5.1.- / DNA Repair Enzymes
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51. Brosens LA, Iacobuzio-Donahue CA, Keller JJ, Hustinx SR, Carvalho R, Morsink FH, Hylind LM, Offerhaus GJ, Giardiello FM, Goggins M: Increased cyclooxygenase-2 expression in duodenal compared with colonic tissues in familial adenomatous polyposis and relationship to the -765G -&gt; C COX-2 polymorphism. Clin Cancer Res; 2005 Jun 1;11(11):4090-6
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  • [Title] Increased cyclooxygenase-2 expression in duodenal compared with colonic tissues in familial adenomatous polyposis and relationship to the -765G -> C COX-2 polymorphism.
  • BACKGROUND: Colorectal cancers arising in patients with familial adenomatous polyposis (FAP) can be largely prevented by polyp surveillance and prophylactic colectomy.
  • As a result, duodenal adenocarcinoma has become a leading cause of death in patients with FAP.
  • Cyclooxygenase 2 (COX-2) inhibition is effective against colorectal polyposis in FAP, but is less effective in treating duodenal polyps.
  • METHODS: The study population included 36 FAP patients with colonic adenomas, 22 FAP patients with duodenal adenomas, 22 patients with sporadic duodenal adenomas, and 17 patients with sporadic duodenal adenocarcinoma.
  • [MeSH-major] Adenoma / pathology. Adenomatous Polyposis Coli / pathology. Colonic Neoplasms / pathology. Duodenal Neoplasms / pathology. Polymorphism, Single Nucleotide. Prostaglandin-Endoperoxide Synthases / genetics

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  • (PMID = 15930344.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / PHS HHS / / 51085; United States / PHS HHS / / 63721; United States / NCI NIH HHS / CA / CA 53801; United States / NCI NIH HHS / CA / P50 CA 93-16; United States / NCI NIH HHS / CA / P50 CA62924
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Proteins; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases
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52. Ho CM, Lai HC, Huang SH, Chien TY, Lin MC, Chang SF: Promoter methylation of sFRP5 in patients with ovarian clear cell adenocarcinoma. Eur J Clin Invest; 2010 Apr;40(4):310-8
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  • [Title] Promoter methylation of sFRP5 in patients with ovarian clear cell adenocarcinoma.
  • BACKGROUND: Specific tumour suppressor genes with promoter methylation in ovarian clear cell adenocarcinoma (OCCA) can be one important epigenetic mark distinguishing OCCA from ovarian serous adenocarcinoma (OSA), benign endometriotic cysts and normal ovarian epitheliums.
  • MATERIALS AND METHODS: Five OCCA cell lines, 63 cancer tissues (48 OCCA and 15 OSA), 10 benign endometriotic cysts and five normal ovarian epitheliums were analysed by methylation-specific PCR using pooled DNAs to determine the methylation status of the promoter of the target genes, including genes for secreted frizzled-related proteins (sFRP1 to 5), adenomatous polyposis coli (APC), retinoblastoma protein 1 (Rb1), breast cancer 1 gene (BRCA1), p14(ARF), p15(INK4b), p16(INK4a) and survivin.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. DNA Methylation. Eye Proteins. Membrane Proteins. Ovarian Neoplasms / pathology


53. Zeng G, Germinaro M, Micsenyi A, Monga NK, Bell A, Sood A, Malhotra V, Sood N, Midda V, Monga DK, Kokkinakis DM, Monga SP: Aberrant Wnt/beta-catenin signaling in pancreatic adenocarcinoma. Neoplasia; 2006 Apr;8(4):279-89
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  • [Title] Aberrant Wnt/beta-catenin signaling in pancreatic adenocarcinoma.
  • The aim of this study is to examine the Wnt/beta-catenin pathway in patients with advanced pancreatic adenocarcinoma (n = 31).
  • Adenomatous polyposis coli and axin, which are both negative regulators, remained unchanged.

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  • (PMID = 16756720.001).
  • [ISSN] 1476-5586
  • [Journal-full-title] Neoplasia (New York, N.Y.)
  • [ISO-abbreviation] Neoplasia
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK062277; United States / NIDDK NIH HHS / DK / 1R01DK62277
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Wnt Proteins; 0 / beta Catenin
  • [Other-IDs] NLM/ PMC1600679
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54. Frattini M, Perrone F, Suardi S, Balestra D, Caramuta S, Colombo F, Licitra L, Cantù G, Pierotti MA, Pilotti S: Phenotype-genotype correlation: challenge of intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses. Head Neck; 2006 Oct;28(10):909-15
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  • [Title] Phenotype-genotype correlation: challenge of intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses.
  • BACKGROUND: Intestinal-type adenocarcinoma (ITAC) of the nasal cavity and paranasal sinuses shows microscopic features indistinguishable from colorectal cancer.
  • METHODS: Twenty consecutive surgically treated ITAC cases, previously investigated for p16(INK4a) and TP53, were investigated for hMLH1, hMSH2, and beta-catenin immunoreactivity, and for adenomatous polyposis coli (APC), K-ras, and BRAF gene mutations.
  • [MeSH-major] Adenocarcinoma / genetics. Nasal Cavity. Nose Neoplasms / genetics. Paranasal Sinus Neoplasms / genetics
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Adenomatous Polyposis Coli Protein / genetics. Carrier Proteins / genetics. Chromosomes, Human, Pair 18 / genetics. Colorectal Neoplasms / genetics. DNA Mismatch Repair. Gene Expression Regulation, Neoplastic. Genes, ras / genetics. Genotype. Humans. Loss of Heterozygosity. MutS Homolog 2 Protein / genetics. Mutation. Nuclear Proteins / genetics. Phenotype. Proto-Oncogene Proteins B-raf / genetics. beta Catenin / genetics

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  • [Copyright] (c) 2006 Wiley Periodicals, Inc.
  • (PMID = 16906516.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Adenomatous Polyposis Coli Protein; 0 / Carrier Proteins; 0 / MLH1 protein, human; 0 / Nuclear Proteins; 0 / beta Catenin; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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55. Murphy HR, Taylor W, Ellis A, Sturgess R: An unusual case of Turcot's syndrome associated with ileal adenocarcinoma, intestinal non-Hodgkin's lymphoma, and duodenal adenocarcinoma. Review of the classification and genetic basis of Turcot's syndrome. Fam Cancer; 2005;4(2):139-43
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  • [Title] An unusual case of Turcot's syndrome associated with ileal adenocarcinoma, intestinal non-Hodgkin's lymphoma, and duodenal adenocarcinoma. Review of the classification and genetic basis of Turcot's syndrome.
  • A 38-year-old man with a history of colonic and small bowel polyposis and glioblastoma was investigated for dyspepsia.
  • Although cases of Turcot's syndrome (TS) (colonic polyposis and primary brain tumour occurring in the same patient) have been previously described, association with haematological malignancy is rare.
  • [MeSH-major] Adenocarcinoma / pathology. Adenomatous Polyposis Coli / pathology. Brain Neoplasms / pathology. Duodenal Neoplasms / pathology. Glioblastoma / pathology. Ileal Neoplasms / pathology. Intestinal Neoplasms / pathology. Lymphoma, B-Cell, Marginal Zone / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 15951965.001).
  • [ISSN] 1389-9600
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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56. Wu R, Hendrix-Lucas N, Kuick R, Zhai Y, Schwartz DR, Akyol A, Hanash S, Misek DE, Katabuchi H, Williams BO, Fearon ER, Cho KR: Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways. Cancer Cell; 2007 Apr;11(4):321-33
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  • [Title] Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways.
  • One histologic subtype of ovarian carcinoma, ovarian endometrioid adenocarcinoma (OEA), frequently harbors mutations that constitutively activate Wnt/beta-catenin-dependent signaling.
  • [MeSH-minor] Adenocarcinoma, Clear Cell / genetics. Adenocarcinoma, Clear Cell / metabolism. Adenocarcinoma, Clear Cell / pathology. Adenocarcinoma, Mucinous / genetics. Adenocarcinoma, Mucinous / metabolism. Adenocarcinoma, Mucinous / pathology. Adenomatous Polyposis Coli Protein / genetics. Adenomatous Polyposis Coli Protein / physiology. Animals. Carcinoma, Endometrioid / genetics. Carcinoma, Endometrioid / metabolism. Carcinoma, Endometrioid / pathology. Cystadenocarcinoma, Serous / genetics. Cystadenocarcinoma, Serous / metabolism. Cystadenocarcinoma, Serous / pathology. Epithelium / metabolism. Epithelium / pathology. Female. Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Humans. Mice. Mutation. Neoplasm Staging. Oligonucleotide Array Sequence Analysis. Ovary / metabolism. Ovary / pathology. Survival Rate. Tumor Suppressor Protein p53 / genetics. Tumor Suppressor Protein p53 / metabolism


57. Iarŭmov N, Toshev S, Petrova D, Angelov K, Gribnev P, Sokolov M: [Genetic counseling, surgical prophylaxis and treatment for familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer]. Khirurgiia (Sofiia); 2007;(3):46-53
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  • [Title] [Genetic counseling, surgical prophylaxis and treatment for familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer].
  • If an adenoma or adenocarcinoma of the colon is identified, total abdominal colectomy with an ileorectal anastomosis is recommended.
  • [MeSH-major] Adenomatous Polyposis Coli. Colorectal Neoplasms, Hereditary Nonpolyposis. Genetic Counseling. Intestine, Large / surgery


58. Reedijk M, Odorcic S, Zhang H, Chetty R, Tennert C, Dickson BC, Lockwood G, Gallinger S, Egan SE: Activation of Notch signaling in human colon adenocarcinoma. Int J Oncol; 2008 Dec;33(6):1223-9
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  • [Title] Activation of Notch signaling in human colon adenocarcinoma.
  • Studies in mice have also shown that Notch signaling is required for adenoma formation in response to elevated Wnt-pathway signaling that occurs in the APCMin mouse model of human adenomatous polyposis coli.

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  • (PMID = 19020755.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U24 CA074783; United States / NCI NIH HHS / CA / RFA#CA-96-011; United States / NCI NIH HHS / CA / U01 CA074783-06; United States / NCI NIH HHS / CA / CA074783-06; United States / NCI NIH HHS / CA / CA074783-05; United States / NCI NIH HHS / CA / U01 CA074783-05; United States / NCI NIH HHS / CA / U01 CA074783
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Calcium-Binding Proteins; 0 / Homeodomain Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Membrane Proteins; 0 / NOTCH1 protein, human; 0 / RNA, Messenger; 0 / Receptor, Notch1; 0 / Receptors, Notch; 134324-36-0 / Serrate proteins; 149348-15-2 / HES1 protein, human; EC 2.4.- / Glycosyltransferases; EC 2.4.1.- / LFNG protein, human
  • [Other-IDs] NLM/ NIHMS139694; NLM/ PMC2739737
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59. Logani S, Oliva E, Arnell PM, Amin MB, Young RH: Use of novel immunohistochemical markers expressed in colonic adenocarcinoma to distinguish primary ovarian tumors from metastatic colorectal carcinoma. Mod Pathol; 2005 Jan;18(1):19-25
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  • [Title] Use of novel immunohistochemical markers expressed in colonic adenocarcinoma to distinguish primary ovarian tumors from metastatic colorectal carcinoma.
  • Recently, three immunohistochemical markers CDX2, a homeobox gene encoding an intestine-specific transcription factor; alpha-methylacyl-CoA racemase (AMACR/P504S), a mitochondrial and peroxisomal enzyme with fairly restricted expression in selective tumors and beta-catenin, an adenomatous polyposis coli (APC) mutation product resulting in activation of the Wnt pathway, have been reported to have specific and sensitive expression in colorectal carcinomas.
  • [MeSH-major] Adenocarcinoma / pathology. Biomarkers / analysis. Colonic Neoplasms / pathology. Colorectal Neoplasms / secondary. Ovarian Neoplasms / pathology

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  • (PMID = 15389251.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / CDX2 protein, human; 0 / CTNNB1 protein, human; 0 / Cytoskeletal Proteins; 0 / Homeodomain Proteins; 0 / Trans-Activators; 0 / beta Catenin; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
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60. Roy UK, Henkhaus RS, Ignatenko NA, Mora J, Fultz KE, Gerner EW: Wild-type APC regulates caveolin-1 expression in human colon adenocarcinoma cell lines via FOXO1a and C-myc. Mol Carcinog; 2008 Dec;47(12):947-55
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  • [Title] Wild-type APC regulates caveolin-1 expression in human colon adenocarcinoma cell lines via FOXO1a and C-myc.
  • We report here, for the first time, that caveolin-1 is transcriptionally induced in colon cancer cells in response to conditional expression of a full length adenomatous polyposis coli (APC) gene.

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  • (PMID = 18444242.001).
  • [ISSN] 1098-2744
  • [Journal-full-title] Molecular carcinogenesis
  • [ISO-abbreviation] Mol. Carcinog.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA72008; United States / NCI NIH HHS / CA / P30 CA023074; United States / NCI NIH HHS / CA / CA95060; United States / NCI NIH HHS / CA / P50 CA095060; United States / NCI NIH HHS / CA / P50 CA095060-05; United States / NCI NIH HHS / CA / R01 CA123065; United States / NCI NIH HHS / CA / P01 CA072008; United States / NCI NIH HHS / CA / P30 CA023074-209010; United States / NCI NIH HHS / CA / R01 CA123065-01A2
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Caveolin 1; 0 / FOXO1 protein, human; 0 / Forkhead Transcription Factors; 0 / Proto-Oncogene Proteins c-myc
  • [Other-IDs] NLM/ NIHMS766917; NLM/ PMC4847746
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61. Constantin V, Socea B, Moculescu C, Sireţeanu G, Popa F: [Enteral non-Hodgkin lymphoma in young age--difficult diagnosis]. Chirurgia (Bucur); 2009 Sep-Oct;104(5):607-10
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  • We present the case of a 22-years-old patient, having colonic polyposis and multicentric non-Hodgkin lymphoma of the terminal ileum and ascending colon.
  • The rest of malignant colonic tumors developed on patients with rectocolonic polyposis were adenocarcinoma.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenomatous Polyposis Coli / diagnosis. Adult. Colectomy / methods. Colon, Ascending / pathology. Diagnosis, Differential. Humans. Male. Prognosis. Treatment Outcome

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  • (PMID = 19943562.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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62. Breuhahn K, Singh S, Schirmacher P, Bläker H: Large-scale N-terminal deletions but not point mutations stabilize beta-catenin in small bowel carcinomas, suggesting divergent molecular pathways of small and large intestinal carcinogenesis. J Pathol; 2008 Jul;215(3):300-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Small intestinal adenocarcinoma is rare and its molecular pathogenesis is incompletely understood.
  • Stabilization of beta-catenin, a mediator of wnt/wingless signalling, can be detected in 50% of sporadic carcinomas but, in contrast to colorectal cancer, this finding can not be explained by the inactivation of adenomatous polyposis coli (APC).
  • In order to elucidate the molecular background of beta-catenin stabilization in small intestinal adenocarcinoma, we investigated 20 non-familial adenomatous polyposis coli (FAP)-associated tumours, including five microsatellite-unstable carcinomas for beta-catenin alterations, by immunohistochemistry, western blot analysis and sequence analysis on the RNA and DNA levels.
  • [MeSH-major] Adenocarcinoma / genetics. Intestinal Neoplasms / genetics. Sequence Deletion. beta Catenin / genetics
  • [MeSH-minor] Adenomatous Polyposis Coli. Adult. Aged. Aged, 80 and over. Cell Nucleus / metabolism. Cell Transformation, Neoplastic. Colorectal Neoplasms / genetics. Cytoplasm / metabolism. DNA Mutational Analysis. Duodenal Neoplasms / genetics. Exons. Female. Genes, APC. Humans. Ileal Neoplasms / genetics. Immunoblotting. Immunohistochemistry. Jejunal Neoplasms / genetics. Male. Middle Aged. Point Mutation. Sequence Analysis, RNA. Wnt Proteins / genetics

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  • [Copyright] Copyright (c) 2008 Pathological Society of Great Britain and Ireland.
  • (PMID = 18491352.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / Wnt Proteins; 0 / beta Catenin
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63. Shao J, Washington MK, Saxena R, Sheng H: Heterozygous disruption of the PTEN promotes intestinal neoplasia in APCmin/+ mouse: roles of osteopontin. Carcinogenesis; 2007 Dec;28(12):2476-83
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  • Number and size of intestinal tumors were significantly increased in mice bearing both adenomatous polyposis coli (APC) and PTEN mutations.
  • Thus, our results suggest that the PI3K pathway promotes the transformation of intestinal adenoma to adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Adenomatous Polyposis Coli / genetics. Colonic Neoplasms / pathology. Osteopontin / physiology. PTEN Phosphohydrolase / physiology

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  • (PMID = 17693663.001).
  • [ISSN] 1460-2180
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK-065615; United States / NIDDK NIH HHS / DK / DK-64593
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Spp1 protein, mouse; 106441-73-0 / Osteopontin; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 3.1.3.48 / Pten protein, mouse; EC 3.1.3.67 / PTEN Phosphohydrolase
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64. Yang Y, Fruehauf J, Xiang S, Li CJ: Genomic instability in precancerous lesions before inactivation of tumor suppressors p53 and APC in patients. Cell Cycle; 2006 Jul;5(13):1443-7
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  • The paradigm that inactivation of tumor suppressors [e.g. p53 or adenomatous polyposis coli (APC) genes] leads to GIN is largely based on experiments in vitro and in animal models.
  • We analyzed specimens from endoscopic biopsies or esophagectomies in patients with BE (ten cases, including five cases with multilayered epithelium (ME)), BE-associated esophageal adenocarcinoma (ten cases), or with normal gastro-esophageal junction (five cases).
  • [MeSH-major] Adenomatous Polyposis Coli Protein / metabolism. Genomic Instability. Precancerous Conditions / genetics. Precancerous Conditions / metabolism. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 16855398.001).
  • [ISSN] 1551-4005
  • [Journal-full-title] Cell cycle (Georgetown, Tex.)
  • [ISO-abbreviation] Cell Cycle
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / Tumor Suppressor Protein p53
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65. Kyrgidis A, Kountouras J, Zavos C, Chatzopoulos D: New molecular concepts of Barrett's esophagus: clinical implications and biomarkers. J Surg Res; 2005 May 15;125(2):189-212
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  • Given that BE is the only known precursor to esophageal adenocarcinoma (EA), a systematic endoscopic biopsy protocol can detect EAs at an early stage.
  • High plasma adenomatous polyposis coli levels correlate with reduced patient survival. p53 expression allows patient risk for EA stratification.
  • [MeSH-major] Adenocarcinoma. Barrett Esophagus. Biomarkers, Tumor / blood. Esophageal Neoplasms. Gastroesophageal Reflux / complications
  • [MeSH-minor] Adenomatous Polyposis Coli Protein / blood. Biomarkers / blood. Cadherins / metabolism. Clinical Trials as Topic. Colorectal Neoplasms / complications. Cyclin D1 / metabolism. Cyclooxygenase 2. Endoscopy, Gastrointestinal. Gene Expression Regulation, Neoplastic. Humans. Membrane Proteins. NF-kappa B / metabolism. Prostaglandin-Endoperoxide Synthases / metabolism. Receptor, ErbB-2 / metabolism. Risk Factors. Survival Rate. Tumor Suppressor Protein p53 / metabolism. Up-Regulation


66. Uchino S, Noguchi S, Yamashita H, Yamashita H, Watanabe S, Ogawa T, Tsuno A, Murakami A, Miyauchi A: Mutational analysis of the APC gene in cribriform-morula variant of papillary thyroid carcinoma. World J Surg; 2006 May;30(5):775-9
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  • INTRODUCTION: Familial adenomatous polyposis (FAP) is an inherited autosomal dominant syndrome caused by germline mutations in the adenomatous polyposis coli (APC) gene.
  • [MeSH-major] Adenocarcinoma, Papillary / genetics. Adenomatous Polyposis Coli / genetics. Genes, APC. Thyroid Neoplasms / genetics. beta Catenin / genetics

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  • [CommentIn] World J Surg. 2007 Jun;31(6):1366-7; author reply 1368-9 [17426899.001]
  • (PMID = 16680592.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Codon; 0 / beta Catenin
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67. Frattini M, Carnevali I, Signoroni S, Balestra D, Moiraghi ML, Radice P, Varesco L, Gismondi V, Ballardini G, Sala P, Pierotti MA, Pilotti S, Bertario L: Cyclooxygenase-2 expression in FAP patients carrying germ line MYH mutations. Cancer Epidemiol Biomarkers Prev; 2005 Aug;14(8):2049-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Familial adenomatous polyposis (FAP) is an autosomal condition caused by inherited mutations in the adenomatous polyposis coli (APC) or in the MYH genes.
  • [MeSH-major] Adenocarcinoma / genetics. Adenomatous Polyposis Coli / genetics. DNA Glycosylases / genetics. Germ-Line Mutation / genetics. Prostaglandin-Endoperoxide Synthases / metabolism

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  • (PMID = 16103460.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Membrane Proteins; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases; EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
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68. Dixon E, Vollmer CM Jr, Sahajpal A, Cattral MS, Grant DR, Taylor BR, Langer B, Gallinger S, Greig PD: Transduodenal resection of peri-ampullary lesions. World J Surg; 2005 May;29(5):649-52
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  • Pathology of the lesions was as follows: 11 with benign ampullary adenomas, including 4 with familial adenomatous polyposis (FAP); 7 with peri-ampullary adenocarcinomas; and 1 with a benign stricture.
  • Three of the 4 patients with FAP have recurrent adenomatous change; 2 of the 7 with carcinoma have metastatic adenocarcinoma.
  • Intraoperative frozen section assessment is recommended in cases of potential adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Digestive System Surgical Procedures
  • [MeSH-minor] Adenomatous Polyposis Coli / surgery. Adult. Aged. Aged, 80 and over. Female. Frozen Sections. Humans. Middle Aged. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 15827855.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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69. Castellví-Bel S, Castells A: [Genetic and molecular biology techniques for the analysis of hereditary colorectal cancer]. Gastroenterol Hepatol; 2005 Jun-Jul;28(6):354-60
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  • The knowledge acquired in genetics and molecular biology over the last 2 decades has led to advances in the molecular diagnosis of some diseases, among them hereditary forms of colorectal cancer such as hereditary non-polyposis colorectal cancer and familial adenomatous polyposis.
  • [MeSH-major] Adenocarcinoma / genetics. Colorectal Neoplasms / genetics. Genetics, Medical / methods. Neoplastic Syndromes, Hereditary / genetics
  • [MeSH-minor] Adenomatous Polyposis Coli / diagnosis. Adenomatous Polyposis Coli / genetics. Algorithms. Colonic Polyps / diagnosis. Colonic Polyps / genetics. Colorectal Neoplasms, Hereditary Nonpolyposis / diagnosis. Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. DNA Mutational Analysis. DNA Repair / genetics. Genes, APC. Genetic Counseling. Genetic Predisposition to Disease. Hamartoma / diagnosis. Hamartoma / genetics. Humans

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  • (PMID = 15989818.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 29
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70. Ogasawara N, Tsukamoto T, Mizoshita T, Inada K, Cao X, Takenaka Y, Joh T, Tatematsu M: Mutations and nuclear accumulation of beta-catenin correlate with intestinal phenotypic expression in human gastric cancer. Histopathology; 2006 Dec;49(6):612-21
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  • Adenomatous polyposis coli (APC) gene mutations were demonstrated only in GI, I and N types, irrespective of beta-catenin localization.
  • [MeSH-major] Adenocarcinoma / genetics. Cell Nucleus / metabolism. Intestines / metabolism. Mutation. Stomach Neoplasms / genetics. beta Catenin / genetics. beta Catenin / metabolism
  • [MeSH-minor] Adenomatous Polyposis Coli Protein / genetics. Adenomatous Polyposis Coli Protein / metabolism. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Cytoplasm / genetics. Cytoplasm / metabolism. Cytoplasm / pathology. DNA Mutational Analysis. DNA, Neoplasm / analysis. Female. Humans. Male. Middle Aged. Phenotype

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  • (PMID = 17163846.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / beta Catenin
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71. Iwamoto M, Hoffenberg EJ, Carethers JM, Doctolero R, Tajima A, Sugano K, Franklin WA, Ahnen DJ: Nuclear accumulation of beta-catenin occurs commonly in the epithelial cells of juvenile polyps. Pediatr Res; 2005 Jan;57(1):4-9; discussion 1-3
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  • In the two conditions juvenile polyps (JPs) and juvenile polyposis coli (JPC), colonic polyps may have overlapping histologic and phenotypic appearance, but JPC confers a significant risk for colon adenocarcinoma.
  • Although not thought to contain adenomatous polyposis coli (APC) mutations, the status of beta-catenin and full-length APC protein expression in JPs is not known.

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  • [CommentIn] Pediatr Res. 2005 Jan;57(1):1-3 [15557110.001]
  • (PMID = 15557107.001).
  • [ISSN] 0031-3998
  • [Journal-full-title] Pediatric research
  • [ISO-abbreviation] Pediatr. Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA090231-04; United States / NCI NIH HHS / CA / R01 CA090231; United States / NCI NIH HHS / CA / CA88007; United States / NCI NIH HHS / CA / CA090231-04; United States / NCI NIH HHS / CA / CA90231
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / CTNNB1 protein, human; 0 / Cytoskeletal Proteins; 0 / Trans-Activators; 0 / Transforming Growth Factor beta; 0 / beta Catenin
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72. Smith GV, Feakins R, Farthing MJ, Ballinger A: Cyclooxygenase 2, p53, beta-catenin, and APC protein expression in gastric adenomatous polyps. Am J Clin Pathol; 2005 Mar;123(3):415-20
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  • In the present study, we immunohisto-chemically assessed the expression of cyclooxygenase (COX)-2, beta-catenin, p53, and adenomatous polyposis coli (APC) in paraffin-embedded specimens of 14 gastric adenomas.
  • Control samples of normal gastric tissue and gastric adenocarcinoma also were analyzed.
  • [MeSH-major] Adenomatous Polyposis Coli Protein / metabolism. Adenomatous Polyps / metabolism. Cytoskeletal Proteins / metabolism. Prostaglandin-Endoperoxide Synthases / metabolism. Stomach Neoplasms / metabolism. Trans-Activators / metabolism. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 15716238.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / Biomarkers, Tumor; 0 / CTNNB1 protein, human; 0 / Cytoskeletal Proteins; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / Trans-Activators; 0 / Tumor Suppressor Protein p53; 0 / beta Catenin; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases
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73. MacLeod RJ, Hayes M, Pacheco I: Wnt5a secretion stimulated by the extracellular calcium-sensing receptor inhibits defective Wnt signaling in colon cancer cells. Am J Physiol Gastrointest Liver Physiol; 2007 Jul;293(1):G403-11
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  • To understand the role of the colonic extracellular calcium-sensing receptor (CaSR) in calcium chemoprotection against colon cancer, we activated the CaSR with 5 mM Ca(2+) on HT-29 cells, an adenocarcinoma cell line.
  • Inducing the expression of full-length adenomatous polyposis coli (APC) prevented CaSRmediated increases of Siah2 and Wnt5a.
  • [MeSH-minor] Adenocarcinoma. Adenomatous Polyposis Coli Protein / biosynthesis. Calcium / pharmacology. Calcium Signaling / drug effects. Cell Line, Tumor. Cells, Cultured. Humans. Nuclear Proteins / biosynthesis. Receptor Tyrosine Kinase-like Orphan Receptors. Receptors, Cell Surface / biosynthesis. Ubiquitin-Protein Ligases / biosynthesis. beta Catenin / antagonists & inhibitors

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  • (PMID = 17463182.001).
  • [ISSN] 0193-1857
  • [Journal-full-title] American journal of physiology. Gastrointestinal and liver physiology
  • [ISO-abbreviation] Am. J. Physiol. Gastrointest. Liver Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / CASR protein, human; 0 / Nuclear Proteins; 0 / Proto-Oncogene Proteins; 0 / ROR2 protein, human; 0 / Receptors, Calcium-Sensing; 0 / Receptors, Cell Surface; 0 / WNT5A protein, human; 0 / Wnt Proteins; 0 / beta Catenin; EC 2.7.10.1 / Receptor Tyrosine Kinase-like Orphan Receptors; EC 6.3.2.19 / Ubiquitin-Protein Ligases; EC 6.3.2.19 / seven in absentia proteins; SY7Q814VUP / Calcium
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74. Schuetze D, Hoschar AP, Seethala RR, Assaad A, Zhang X, Hunt JL: The T1799A BRAF mutation is absent in cribriform-morular variant of papillary carcinoma. Arch Pathol Lab Med; 2009 May;133(5):803-5
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  • It has been associated with familial adenomatous polyposis, though it can also occur sporadically.
  • DESIGN: Four cases of CMVPTC (1 associated with familial adenomatous polyposis and the others apparently sporadic) were identified from the files of 3 large centers.
  • [MeSH-major] Adenocarcinoma, Papillary / genetics. Point Mutation. Proto-Oncogene Proteins B-raf / genetics. Thyroid Neoplasms / genetics
  • [MeSH-minor] Adenomatous Polyposis Coli / genetics. Adenomatous Polyposis Coli / pathology. DNA Mutational Analysis. DNA, Neoplasm / analysis. Humans

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  • (PMID = 19415957.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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75. Croitoru ME, Cleary SP, Berk T, Di Nicola N, Kopolovic I, Bapat B, Gallinger S: Germline MYH mutations in a clinic-based series of Canadian multiple colorectal adenoma patients. J Surg Oncol; 2007 May 1;95(6):499-506
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  • METHODS: We screened for germline MYH mutations (by dHPLCO) in 20 clinic-based multiple adenoma patients who were adenomatous polyposis coli (APC) mutation-negative.
  • [MeSH-major] Adenoma / genetics. Adenomatous Polyposis Coli / genetics. Colorectal Neoplasms / genetics. DNA Glycosylases / genetics. Germ-Line Mutation
  • [MeSH-minor] Adenocarcinoma / genetics. Adult. Aged. DNA Mutational Analysis. DNA, Neoplasm / analysis. Female. Genetic Predisposition to Disease. Heterozygote. Humans. Male. Middle Aged. Pedigree

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  • [Copyright] Copyright 2007 Wiley-Liss, Inc.
  • (PMID = 17219385.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
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76. Dai WB, Ren ZP, Chen WL, DU J, Shi Z, Tang DY: [Expression and significance of APC, beta-catenin, C-myc, and Cyclin D1 proteins in colorectal carcinoma]. Ai Zheng; 2007 Sep;26(9):963-6
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  • This study was to examine the expression of adenomatous polyposis coli (APC), beta-catenin, C-myc, and Cyclin D1 in different colorectal tissues, and investigate their possible roles in the carcinogenesis of colorectal carcinoma.
  • [MeSH-major] Adenomatous Polyposis Coli Protein / metabolism. Colorectal Neoplasms / metabolism. Cyclin D1 / metabolism. Proto-Oncogene Proteins c-myc / metabolism. beta Catenin / metabolism
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenoma / metabolism. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Intestinal Mucosa / metabolism. Precancerous Conditions / metabolism

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  • (PMID = 17927853.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / CCND1 protein, human; 0 / Proto-Oncogene Proteins c-myc; 0 / beta Catenin; 136601-57-5 / Cyclin D1
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77. Bellizzi AM, Kahaleh M, Stelow EB: The assessment of specimens procured by endoscopic ampullectomy. Am J Clin Pathol; 2009 Oct;132(4):506-13
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  • Familial adenomatous polyposis (FAP) status and the endoscopist's impression of completeness of removal were also ascertained.
  • The histologic features of the ampullectomy specimens were as follows: diagnosis (no diagnostic abnormality, 3; reactive, 8; adenoma, 26; adenocarcinoma, 7; other, 1); HGD, 1; submucosal ampullary gland/ductule involvement, 20; specimen integrity (intact, 22; fragmented, 23); and margin status (positive, 20; negative, 2; could not be assessed, 12).
  • [MeSH-minor] Adenocarcinoma / pathology. Adenomatous Polyposis Coli / pathology. Adult. Aged. Aged, 80 and over. Cholangiopancreatography, Endoscopic Retrograde. Female. Humans. Male. Middle Aged

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  • (PMID = 19762527.001).
  • [ISSN] 1943-7722
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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78. Soravia C, DeLozier CD, Dobbie Z, Berthod CR, Arrigoni E, Bründler MA, Blouin JL, Foulkes WD, Hutter P: Double frameshift mutations in APC and MSH2 in the same individual. Int J Colorectal Dis; 2006 Jan;21(1):79-83
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  • Here we report the case of a proband whose father was known for familial adenomatous polyposis.
  • The number of polyps (less than ten) was not typical of polyposis; therefore, the diagnosis of HNPCC was entertained.
  • Prophylactic colectomy was performed, and an adenocarcinoma developing within the adenoma was diagnosed (pT1N0).
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. Frameshift Mutation. Genes, APC. Genetic Predisposition to Disease. MutS Homolog 2 Protein / genetics

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  • [RepublishedFrom] Int J Colorectal Dis. 2005 Sep;20(5):466-470 [15834612.001]
  • (PMID = 16676398.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Corrected and Republished Article; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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79. Soravia C, DeLozier CD, Dobbie Z, Berthod CR, Arrigoni E, Bründler MA, Blouin JL, Foulkes WD, Hutter P: Double frameshift mutations in APC and MSH2 in the same individual. Int J Colorectal Dis; 2005 Sep;20(5):466-470
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Here we report the case of a proband whose father was known for familial adenomatous polyposis.
  • The number of polyps (less than ten) was not typical of polyposis; therefore, the diagnosis of HNPCC was entertained.
  • Prophylactic colectomy was performed, and an adenocarcinoma developing within the adenoma was diagnosed (pT1N0).
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. Frameshift Mutation. Genes, APC. MutS Homolog 2 Protein / genetics

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  • [ErratumIn] Int J Colorectal Dis. 2007 Mar;22(3):339
  • [RepublishedIn] Int J Colorectal Dis. 2006 Jan;21(1):79-83 [16676398.001]
  • (PMID = 15834612.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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80. Benito M, Díaz-Rubio E: Molecular biology in colorectal cancer. Clin Transl Oncol; 2006 Jun;8(6):391-8
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  • High-penetrance mutations confer predisposition to colorectal cancer mainly in Lynch syndrome (which involves mutations in mismatch-repair genes) and in familial adenomatous polyposis (which involves mutations in the APC tumour suppressor).
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / genetics. Adenoma / epidemiology. Adenoma / genetics. Adenomatous Polyposis Coli / epidemiology. Adenomatous Polyposis Coli / genetics. Base Pair Mismatch. Cell Transformation, Neoplastic / genetics. Colorectal Neoplasms, Hereditary Nonpolyposis / epidemiology. Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. DNA Repair / genetics. Disease Progression. Ethnic Groups / genetics. Genes, APC. Genes, Tumor Suppressor. Genetic Predisposition to Disease. Genetic Testing. Germ-Line Mutation. Humans. Incidence. Mutation. Penetrance. Peutz-Jeghers Syndrome / epidemiology. Peutz-Jeghers Syndrome / genetics

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  • (PMID = 16790391.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Spain
  • [Number-of-references] 9
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81. Kim JC, Roh SA, Cho DH, Kim TW, Yoon SN, Kim CW, Yu CS, Kim SY, Kim YS: Chemoresponsiveness associated with canonical molecular changes in colorectal adenocarcinomas. Anticancer Res; 2009 Aug;29(8):3115-23
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  • Representative molecular changes in tumor tissues, including adenomatous polyposis coli (APC) gene, wingless-type MMTV integration site family (Wnt), mismatch repair (MMR), RAF, transforming growth factor (TGF)-beta, bone morphogenetic protein, and p53, had been previously determined, with an additional 42 patients included in this analysis.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / genetics. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / genetics. Colorectal Neoplasms / drug therapy. Colorectal Neoplasms / genetics
  • [MeSH-minor] Adenomatous Polyposis Coli Protein / genetics. Adenomatous Polyposis Coli Protein / metabolism. Chemotherapy, Adjuvant. DNA Mismatch Repair. Disease-Free Survival. Female. Humans. Immunoenzyme Techniques. Loss of Heterozygosity. Male. Microsatellite Instability. Middle Aged. Mutation. Neoplasm Invasiveness. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / genetics. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Palliative Care. Survival Rate. Transforming Growth Factor beta2 / genetics. Transforming Growth Factor beta2 / metabolism. Tumor Suppressor Protein p53 / genetics. Tumor Suppressor Protein p53 / metabolism. Wnt Proteins / genetics. Wnt Proteins / metabolism. raf Kinases / genetics. raf Kinases / metabolism

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  • (PMID = 19661324.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / Biomarkers, Tumor; 0 / TP53 protein, human; 0 / Transforming Growth Factor beta2; 0 / Tumor Suppressor Protein p53; 0 / Wnt Proteins; EC 2.7.11.1 / raf Kinases
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82. Femia AP, Giannini A, Fazi M, Tarquini E, Salvadori M, Roncucci L, Tonelli F, Dolara P, Caderni G: Identification of mucin depleted foci in the human colon. Cancer Prev Res (Phila); 2008 Dec;1(7):562-7

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  • Familial adenomatous polyposis (FAP) subjects, carrying germ-line mutations in the APC gene, are at high risk of CRC.
  • [MeSH-major] Adenocarcinoma / pathology. Adenomatous Polyposis Coli / pathology. Colonic Neoplasms / pathology. Mucins / metabolism. Precancerous Conditions / pathology

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  • (PMID = 19139006.001).
  • [ISSN] 1940-6215
  • [Journal-full-title] Cancer prevention research (Philadelphia, Pa.)
  • [ISO-abbreviation] Cancer Prev Res (Phila)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Mucins
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83. Kim JC, Ka IH, Lee YM, Koo KH, Kim HC, Yu CS, Jang SJ, Kim YS, Lee HI, Lee KH: MYH, OGG1, MTH1, and APC alterations involved in the colorectal tumorigenesis of Korean patients with multiple adenomas. Virchows Arch; 2007 Mar;450(3):311-9
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  • This study was done to characterize base excision repair (BER) genes and adenomatous polyposis coli (APC) alterations in the tumorigenesis of multiple colorectal adenomas in Korean patients.
  • The G:C>T:A transversion or attenuated familial adenomatous polyposis (AFAP) mutations of APC was identified in the specific genotypes of BER variants.
  • [MeSH-major] Adenocarcinoma / genetics. Adenoma / genetics. Biomarkers, Tumor / genetics. Colorectal Neoplasms / genetics. Mutation. Neoplasms, Multiple Primary / genetics
  • [MeSH-minor] Adenomatous Polyposis Coli / genetics. Adenomatous Polyposis Coli / metabolism. Adult. Aged. Aged, 80 and over. DNA Glycosylases / genetics. DNA Glycosylases / metabolism. DNA Mismatch Repair. DNA Mutational Analysis. DNA Repair Enzymes / genetics. DNA Repair Enzymes / metabolism. DNA-(Apurinic or Apyrimidinic Site) Lyase / genetics. DNA-(Apurinic or Apyrimidinic Site) Lyase / metabolism. Female. Humans. Male. Middle Aged. Mitochondrial Proteins / genetics. Mitochondrial Proteins / metabolism. N-Glycosyl Hydrolases / genetics. N-Glycosyl Hydrolases / metabolism. Neoplasm Staging. Phosphoric Monoester Hydrolases / genetics. Phosphoric Monoester Hydrolases / metabolism. Polymorphism, Single Nucleotide. Prospective Studies

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  • (PMID = 17252231.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mitochondrial Proteins; EC 3.1.3.- / Phosphoric Monoester Hydrolases; EC 3.1.6.- / 8-oxodGTPase; EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / N-Glycosyl Hydrolases; EC 3.2.2.- / mutY adenine glycosylase; EC 3.2.2.- / oxoguanine glycosylase 1, human; EC 4.2.99.18 / DNA-(Apurinic or Apyrimidinic Site) Lyase; EC 6.5.1.- / DNA Repair Enzymes
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84. Chambers WM, McC Mortensen NJ: Should ileal pouch-anal anastomosis include mucosectomy? Colorectal Dis; 2007 Jun;9(5):384-92
Hazardous Substances Data Bank. ARSENIC ACID .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: Debate exists as to the benefits of performing mucosectomy as part of pouch surgery for ulcerative colitis (UC) and familial adenomatous polyposis (FAP).
  • Potential reasons for functional problems were investigated, as were rates of 'cuffitis', dysplasia, polyposis and cancer in the ileal pouch and anal canal.
  • Performing mucosectomy results in some clinical benefits in terms of lower rates of inflammation and dysplasia in the retained mucosa in UC patients and lower rates of cuff polyposis in FAP patients.
  • [MeSH-minor] Adenocarcinoma / prevention & control. Adenomatous Polyposis Coli / surgery. Anastomosis, Surgical / adverse effects. Anastomosis, Surgical / methods. Anus Neoplasms / prevention & control. Arsenates. Colitis, Ulcerative / surgery. Humans. Ileal Neoplasms / prevention & control. Randomized Controlled Trials as Topic

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  • (PMID = 17504334.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Arsenates; N7CIZ75ZPN / arsenic acid
  • [Number-of-references] 70
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85. Rio Frio T, Lavoie J, Hamel N, Geyer FC, Kushner YB, Novak DJ, Wark L, Capelli C, Reis-Filho JS, Mai S, Pastinen T, Tischkowitz MD, Marcus VA, Foulkes WD: Homozygous BUB1B mutation and susceptibility to gastrointestinal neoplasia. N Engl J Med; 2010 Dec 30;363(27):2628-37
SciCrunch. Clinical Genomic Database: Data: Gene Annotation .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A patient received a diagnosis of adenocarcinoma of the ampulla of Vater at 34 years of age.
  • Our findings expand the phenotype associated with BUB1B mutations and the mosaic variegated aneuploidy syndrome to include common adult-onset cancers and provide evidence for the interdependency of the APC protein (encoded by the adenomatous polyposis coli gene) and the BUBR1 protein (encoded by BUB1B) in humans. (Funded by the Turner Family Cancer Research Fund and others.).
  • [MeSH-minor] Adenocarcinoma / genetics. Adenoma / genetics. Adenomatous Polyposis Coli Protein / genetics. Adenomatous Polyposis Coli Protein / metabolism. Aged. Chromosome Disorders / genetics. DNA Mutational Analysis. Female. Genomic Instability. Homozygote. Humans. Karyotyping. Male. Mosaicism. Oligonucleotide Array Sequence Analysis. Pedigree. Phenotype. Spindle Apparatus

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  • [CommentIn] N Engl J Med. 2010 Dec 30;363(27):2665-6 [21190461.001]
  • [CommentIn] N Engl J Med. 2011 Mar 31;364(13):1279-80 [21449797.001]
  • (PMID = 21190457.001).
  • [ISSN] 1533-4406
  • [Journal-full-title] The New England journal of medicine
  • [ISO-abbreviation] N. Engl. J. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; EC 2.7.11.1 / BUB1 protein, human; EC 2.7.11.1 / Bub1 spindle checkpoint protein; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; Mosaic variegated aneuploidy syndrome
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86. Gatalica Z, Torlakovic E: Pathology of the hereditary colorectal carcinoma. Fam Cancer; 2008;7(1):15-26

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The most common form of hereditary CRC is Lynch syndrome (hereditary non-polyposis colorectal cancer, HNPCC) which is characterized by proximally located tumors frequently showing mucinous and medullary type histologic features.
  • Hereditary CRC may also arise in various familial polyposis syndromes which include familial adenomatous polyposis (FAP), attenuated FAP and other multiple adenomas syndromes as well as various hamartomatous polyposis syndromes.
  • [MeSH-major] Adenomatous Polyposis Coli / pathology. Colorectal Neoplasms, Hereditary Nonpolyposis / pathology. Lymphocytes, Tumor-Infiltrating / pathology. Peutz-Jeghers Syndrome / pathology
  • [MeSH-minor] Adenocarcinoma, Mucinous / pathology. Biomarkers, Tumor. Carcinoma, Medullary / pathology. DNA Mismatch Repair. Diagnosis, Differential. Genetic Predisposition to Disease. Genomic Instability. Germ-Line Mutation. Humans

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  • (PMID = 17564815.001).
  • [ISSN] 1389-9600
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 96
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87. Hata K, Tanaka T, Kohno H, Suzuki R, Qiang SH, Yamada Y, Oyama T, Kuno T, Hirose Y, Hara A, Mori H: beta-Catenin-accumulated crypts in the colonic mucosa of juvenile ApcMin/+ mice. Cancer Lett; 2006 Jul 28;239(1):123-8
Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .

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  • Although Apc(Min/+) mice are widely used for an animal model of human familial adenomatous polyposis (FAP), a majority of intestinal polyps locate in the small intestine.
  • We recently reported that numerous beta-catenin-accumulated crypts (BCAC), which are reliable precursor lesions for colonic adenocarcinoma, develop in the large bowel of aged Apc(Min/+) mice.
  • [MeSH-major] Adenoma / metabolism. Adenomatous Polyposis Coli / metabolism. Colon / metabolism. Colonic Neoplasms / metabolism. Intestinal Mucosa / metabolism. beta Catenin / metabolism

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  • (PMID = 16168560.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / beta Catenin
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88. Bafandeh Y, Daghestani D, Esmaili H, Aharizad S: Distribution of cancer and adenomatous polyps in the colorectum: study in an Iranian population. Asian Pac J Cancer Prev; 2006 Jan-Mar;7(1):65-8
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Patients with polyposis syndromes were excluded the analysis.
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Adenomatous Polyposis Coli / epidemiology. Adenomatous Polyposis Coli / pathology. Colorectal Neoplasms / epidemiology. Colorectal Neoplasms / pathology

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  • (PMID = 16629518.001).
  • [ISSN] 1513-7368
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Thailand
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89. Hoffmann AC, Vallböhmer D, Prenzel K, Metzger R, Heitmann M, Neiss S, Ling F, Hölscher AH, Schneider PM, Brabender J: Methylated DAPK and APC promoter DNA detection in peripheral blood is significantly associated with apparent residual tumor and outcome. J Cancer Res Clin Oncol; 2009 Sep;135(9):1231-7
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Death-associated protein kinase (DAPK) and adenomatous polyposis coli gene (APC) have been recently shown to be associated with outcome in patients with esophageal carcinoma, especially adenocarcinoma.
  • CONCLUSIONS: Preoperative measurement of methylated DAPK and APC promoter DNA in peripheral blood may contribute to better estimate postoperative survival chances of patients with esophageal carcinoma, especially adenocarcinoma.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Apoptosis Regulatory Proteins / genetics. Calcium-Calmodulin-Dependent Protein Kinases / genetics. DNA Methylation / genetics. DNA, Neoplasm / blood. Esophageal Neoplasms / genetics. Neoplasm, Residual / genetics. Promoter Regions, Genetic / genetics

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  • (PMID = 19259700.001).
  • [ISSN] 1432-1335
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; EC 2.7.11.1 / Death-Associated Protein Kinases; EC 2.7.11.17 / Calcium-Calmodulin-Dependent Protein Kinases
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90. Schneider AR, Seifert H, Trojan J, Stein J, Hoepffner NM: Frequency of colorectal polyps in patients with sporadic adenomas or adenocarcinomas of the papilla of vater--an age-matched, controlled study. Z Gastroenterol; 2005 Oct;43(10):1123-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Patients with familial adenomatous polyposis bear a particularly increased risk for periampullary tumors.
  • [MeSH-major] Adenocarcinoma / complications. Adenoma / complications. Ampulla of Vater. Common Bile Duct Neoplasms / complications. Intestinal Polyps / epidemiology
  • [MeSH-minor] Adenoma, Villous / complications. Adenoma, Villous / surgery. Adenomatous Polyposis Coli / epidemiology. Adult. Aged. Aged, 80 and over. Colonic Polyps / diagnosis. Colonic Polyps / epidemiology. Colonoscopy. Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / epidemiology. Data Interpretation, Statistical. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prevalence. Retrospective Studies. Risk Factors. Time Factors

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  • (PMID = 16220451.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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91. Lualdi M, Colombo A, Leo E, Morelli D, Vannelli A, Battaglia L, Poiasina E, Marchesini R: Natural fluorescence spectroscopy of human blood plasma in the diagnosis of colorectal cancer: feasibility study and preliminary results. Tumori; 2007 Nov-Dec;93(6):567-71
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PATIENTS AND METHODS: The study involved 341 subjects, including 169 blood donors with no evidence of disease, 143 patients bearing colorectal adenocarcinomas (36 in the colon, 38 in the sigmoid colon and 69 in the rectum), 11 patients with local relapse, 10 patients with familial adenomatous polyposis and 8 with single adenomas.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenoma / diagnosis. Adenomatous Polyposis Coli / diagnosis. Adult. Aged. Area Under Curve. Blood Donors. Feasibility Studies. Female. Humans. Male. Middle Aged. ROC Curve

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  • (PMID = 18338491.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Porphyrins
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92. Kets CM, Hoogerbrugge N, Bodmer D, Willems R, Brunner HG, van Krieken JH, Ligtenberg MJ: Unfavorable pathological characteristics in familial colorectal cancer with low-level microsatellite instability. Mod Pathol; 2006 Dec;19(12):1624-30
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A high degree of microsatellite instability (MSI) in colorectal cancer (CRC) is a hallmark of hereditary non-polyposis colorectal cancer (HNPCC), caused by germline defects in the mismatch repair (MMR) genes.
  • [MeSH-major] Adenocarcinoma / genetics. Adenomatous Polyposis Coli / genetics. Colorectal Neoplasms / genetics. Genetic Predisposition to Disease. Microsatellite Instability

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  • (PMID = 16980941.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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93. John R, El-Rouby NM, Tomasetto C, Rio MC, Karam SM: Expression of TFF3 during multistep colon carcinogenesis. Histol Histopathol; 2007 07;22(7):743-51
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Colonic tissues representing colitis, adenomatous polyposis, tubulovillous adenoma, and mucoid/adeno-carcinomas were processed for immunohistochemistry using an antibody specific for human TFF3.
  • The data showed marked down-regulation of TFF3 expression in adenomatous polyposis, then TFF3 expression returns to about control level during adenoma and remains high during mucoid- and adeno-carcinomas.
  • [MeSH-major] Adenocarcinoma, Mucinous / chemistry. Adenoma, Villous / chemistry. Adenomatous Polyposis Coli / chemistry. Colitis / metabolism. Colonic Neoplasms / chemistry. Peptides / analysis

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  • (PMID = 17455148.001).
  • [ISSN] 1699-5848
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Peptides; 0 / Proliferating Cell Nuclear Antigen; 0 / TFF3 protein, human; 0 / Trefoil Factor-3
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94. Bhatnagar N, Li X, Chen Y, Zhou X, Garrett SH, Guo B: 3,3'-diindolylmethane enhances the efficacy of butyrate in colon cancer prevention through down-regulation of survivin. Cancer Prev Res (Phila); 2009 Jun;2(6):581-9
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We recently showed that mutations in the adenomatous polyposis coli (APC) gene confer resistance to HDAC inhibitor-induced apoptosis in colon cancers.
  • We further showed that DIM was able to down-regulate survivin and enhance the effects of butyrate in apoptosis induction and prevention of familial adenomatous polyposis in APC(min/+) mice.

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  • (PMID = 19470789.001).
  • [ISSN] 1940-6215
  • [Journal-full-title] Cancer prevention research (Philadelphia, Pa.)
  • [ISO-abbreviation] Cancer Prev Res (Phila)
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R03 CA130062; United States / NCI NIH HHS / CA / 5R21CA111765; United States / NCRR NIH HHS / RR / 2P20RR015566; United States / NCI NIH HHS / CA / 1R03CA130062; United States / NCI NIH HHS / CA / R03 CA130062-02; United States / NIGMS NIH HHS / GM / P30 GM103332; United States / NCRR NIH HHS / RR / P20 RR015566; United States / NCRR NIH HHS / RR / P20 RR015566-08; United States / NCRR NIH HHS / RR / RR015566-08; United States / NCI NIH HHS / CA / R21 CA111765; United States / NCI NIH HHS / CA / CA130062-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / BIRC5 protein, human; 0 / Butyrates; 0 / DNA, Complementary; 0 / Histone Deacetylase Inhibitors; 0 / Indoles; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; 0 / Recombinant Fusion Proteins; SSZ9HQT61Z / 3,3'-diindolylmethane
  • [Other-IDs] NLM/ NIHMS209111; NLM/ PMC2901098
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95. Ouaïssi M, Sielezneff I, Alves A, Pirro N, Heyries L, Robitail S, Consentino B, Payan MJ, Valleur P, Panis Y, Sastre B: [Long term outcome following 26 surgical ampullectomies]. Ann Chir; 2006 May;131(5):322-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Of the 26 patients, 8 had familial adenomatous polyposis (FAP).
  • [MeSH-minor] Adenocarcinoma / surgery. Adenoma / surgery. Adenomatous Polyposis Coli / surgery. Adult. Aged. Carcinoma in Situ / surgery. Cause of Death. Common Bile Duct Diseases / surgery. Female. Follow-Up Studies. Granuloma, Plasma Cell / surgery. Humans. Longitudinal Studies. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Retrospective Studies. Somatostatinoma / surgery. Survival Rate. Treatment Outcome

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  • (PMID = 16615931.001).
  • [ISSN] 0003-3944
  • [Journal-full-title] Annales de chirurgie
  • [ISO-abbreviation] Ann Chir
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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96. Ferrari A, Rognone A, Casanova M, Zaffignani E, Piva L, Collini P, Bertario L, Sala P, Leo E, Belli F, Gallino G: Colorectal carcinoma in children and adolescents: the experience of the Istituto Nazionale Tumori of Milan, Italy. Pediatr Blood Cancer; 2008 Mar;50(3):588-93
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PATIENTS AND METHODS: Among the children/adolescents (age 9-18, median 12 years), 5/7 had unfavorable CRC histotypes (poorly differentiated or mucinous adenocarcinoma) and all but one had advanced disease at onset.
  • [MeSH-major] Adenocarcinoma / epidemiology. Colorectal Neoplasms / epidemiology
  • [MeSH-minor] Adenocarcinoma, Mucinous / drug therapy. Adenocarcinoma, Mucinous / epidemiology. Adenocarcinoma, Mucinous / genetics. Adenocarcinoma, Mucinous / surgery. Adenomatous Polyposis Coli / epidemiology. Adolescent. Adult. Age of Onset. Antineoplastic Agents / therapeutic use. Chemotherapy, Adjuvant. Child. Colorectal Neoplasms, Hereditary Nonpolyposis / epidemiology. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Italy / epidemiology. Male. Neoplasms, Second Primary / epidemiology. Prognosis. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17405155.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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97. Cameselle-Teijeiro J, Menasce LP, Yap BK, Colaco RJ, Castro P, Celestino R, Ruíz-Ponte C, Soares P, Sobrinho-Simões M: Cribriform-morular variant of papillary thyroid carcinoma: molecular characterization of a case with neuroendocrine differentiation and aggressive behavior. Am J Clin Pathol; 2009 Jan;131(1):134-42
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We describe an especially aggressive case of cribriform-morular variant (C-MV) of papillary thyroid carcinoma (PTC) in a 42-year-old man with familial adenomatous polyposis who died with lung and brain metastases 17 months after thyroidectomy.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Papillary / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adenomatous Polyposis Coli / pathology. Adult. Brain Neoplasms / secondary. Fatal Outcome. Humans. Lung Neoplasms / secondary. Male

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  • (PMID = 19095577.001).
  • [ISSN] 1943-7722
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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98. Herbst A, Bommer GT, Kriegl L, Jung A, Behrens A, Csanadi E, Gerhard M, Bolz C, Riesenberg R, Zimmermann W, Dietmaier W, Wolf I, Brabletz T, Göke B, Kolligs FT: ITF-2 is disrupted via allelic loss of chromosome 18q21, and ITF-2B expression is lost at the adenoma-carcinoma transition. Gastroenterology; 2009 Aug;137(2):639-48, 648.e1-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • ITF-2B, which is up-regulated during early colorectal carcinogenesis because of loss of adenomatous polyposis coli, is a target for LOH on chromosome 18q, along with deleted in colorectal carcinoma and Smad4.
  • [MeSH-major] Adenocarcinoma / genetics. Adenomatous Polyposis Coli / genetics. Basic Helix-Loop-Helix Transcription Factors / genetics. Cell Transformation, Neoplastic / genetics. Chromosomes, Human, Pair 18 / genetics. Colorectal Neoplasms / genetics. DNA-Binding Proteins / genetics. Transcription Factors / genetics

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  • (PMID = 19394332.001).
  • [ISSN] 1528-0012
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / DNA-Binding Proteins; 0 / Neoplasm Proteins; 0 / TCF3 protein, human; 0 / TCF4 protein, human; 0 / Transcription Factors
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99. Palanivelu C, Rangarajan M, Jategaonkar PA, Anand NV: An innovative technique for colorectal specimen retrieval: a new era of "natural orifice specimen extraction" (N.O.S.E). Dis Colon Rectum; 2008 Jul;51(7):1120-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The indication for surgery was familial polyposis coexisting with adenocarcinoma of the upper rectum.
  • [MeSH-major] Adenocarcinoma / surgery. Adenomatous Polyposis Coli / surgery. Proctocolectomy, Restorative / methods. Rectal Neoplasms / surgery. Vagina / surgery

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  • [CommentIn] Dis Colon Rectum. 2010 Apr;53(4):502-3; author reply 503 [20305453.001]
  • (PMID = 18481149.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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100. Brücher BL, Geddert H, Langner C, Höfler H, Fink U, Siewert JR, Sarbia M: Hypermethylation of hMLH1, HPP1, p14(ARF), p16(INK4A) and APC in primary adenocarcinomas of the small bowel. Int J Cancer; 2006 Sep 15;119(6):1298-302
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Small bowel adenocarcinoma (SB-AC) is a very rare tumor entity.
  • [MeSH-major] Adenocarcinoma / genetics. DNA Methylation. Intestinal Neoplasms / genetics. Intestine, Small / pathology. Neoplasm Proteins / genetics
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Adenomatous Polyposis Coli Protein / genetics. Adult. Aged. Aged, 80 and over. Carrier Proteins / genetics. Cyclin-Dependent Kinase Inhibitor p16 / genetics. DNA, Neoplasm / genetics. Female. Humans. Male. Membrane Proteins / genetics. Middle Aged. Nuclear Proteins / genetics. Tumor Suppressor Protein p14ARF / genetics

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  • (PMID = 16619216.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Adenomatous Polyposis Coli Protein; 0 / Carrier Proteins; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Neoplasm; 0 / MLH1 protein, human; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / TMEFF2 protein, human; 0 / Tumor Suppressor Protein p14ARF
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