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1. Alberts DS: Reducing the risk of colorectal cancer by intervening in the process of carcinogenesis: a status report. Cancer J; 2002 May-Jun;8(3):208-21
Hazardous Substances Data Bank. CELECOXIB .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The transition from normal colonic mucosa to adenomatous polyp to adenocarcinoma is a gradual process involving genetic and epigenetic instability that can take decades, offering numerous opportunities for early detection (e.g., colonoscopy screenings), lifestyle changes (e.g., reduced red meat intake, increased physical activity, and reduced alcohol/ tobacco exposure), and chemopreventive interventions.
  • Aspirin and various other nonsteroidal anti-inflammatory drugs may have chemopreventive benefits for colorectal cancer and other human epithelial carcinomas, butthe long-term use of nonsteroidal anti-inflammatory drugs is associated with serious gastrointestinal side effects.
  • Celecoxib has been approved for the management of familial adenomatous polyposis and is under investigation for the management of sporadic colorectal polyps and for its potential as a chemopreventive agent for other cancers.
  • [MeSH-minor] Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Celecoxib. Clinical Trials, Phase III as Topic. Cyclooxygenase Inhibitors / therapeutic use. Humans. Prognosis. Pyrazoles. Risk Factors. Sulfonamides / therapeutic use

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  • (PMID = 12074318.001).
  • [ISSN] 1528-9117
  • [Journal-full-title] Cancer journal (Sudbury, Mass.)
  • [ISO-abbreviation] Cancer J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Cyclooxygenase Inhibitors; 0 / Pyrazoles; 0 / Sulfonamides; JCX84Q7J1L / Celecoxib
  • [Number-of-references] 128
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2. Iishi H, Tatsuta M, Baba M, Yano H, Sakai N, Uehara H, Nakaizumi A: ras p21 Isoprenylation inhibition induces flat colon tumors in Wistar rats. Dis Colon Rectum; 2000 Jan;43(1):70-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: The effect of pravastatin, an inhibitor of ras p21 isoprenylation, on the gross type of colon tumors induced by azoxymethane was investigated in Wistar rats.
  • CONCLUSIONS: These findings suggest that the ras oncogene may be closely related to the development of adenocarcinomas from adenomas and the development of elevated or polypoid tumors of the colon.
  • [MeSH-major] Azoxymethane / adverse effects. Carcinogens / adverse effects. Colonic Neoplasms / chemically induced. Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology. Oncogene Protein p21(ras) / antagonists & inhibitors. Pravastatin / pharmacology. Protein Prenylation / drug effects
  • [MeSH-minor] Adenocarcinoma / chemically induced. Adenocarcinoma / genetics. Adenocarcinoma / pathology. Adenoma / chemically induced. Adenoma / genetics. Adenoma / pathology. Analysis of Variance. Animals. Antimetabolites. Apoptosis / drug effects. Blotting, Western. Bromodeoxyuridine. Colonic Polyps / chemically induced. Colonic Polyps / genetics. Colonic Polyps / pathology. Genes, ras / genetics. Incidence. Injections, Intraperitoneal. Injections, Subcutaneous. Male. Point Mutation / genetics. Prevalence. Random Allocation. Rats. Rats, Wistar

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  • (PMID = 10813127.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Antimetabolites; 0 / Carcinogens; 0 / Hydroxymethylglutaryl-CoA Reductase Inhibitors; EC 3.6.5.2 / Oncogene Protein p21(ras); G34N38R2N1 / Bromodeoxyuridine; KXO2KT9N0G / Pravastatin; MO0N1J0SEN / Azoxymethane
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