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1. Beggs AD, Hodgson SV: The genomics of colorectal cancer: state of the art. Curr Genomics; 2008 Mar;9(1):1-10

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  • The concept of the adenoma-carcinoma sequence, as first espoused by Morson et al. whereby the development of colorectal cancer is dependent on a stepwise progression from adenomatous polyp to carcinoma is well documented.
  • Initial studies of the genetics of inherited colorectal cancer susceptibility concentrated on the inherited colorectal cancer syndromes, such as Familial Adenomatous Polyposis (FAP) and Lynch Syndrome (also known as HNPCC).
  • Recent research has concentrated on the pathways by which colorectal adenomatous polyps not due to one of these known inherited susceptibilities undergo malignant transformation, and determination of the types of polyps most likely to do so.

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  • (PMID = 19424478.001).
  • [ISSN] 1389-2029
  • [Journal-full-title] Current genomics
  • [ISO-abbreviation] Curr. Genomics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC2674304
  • [Keywords] NOTNLM ; Colorectal / cancer / epigenomics. / genomics
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2. Hirata I, Wang FY, Murano M, Inoue T, Toshina K, Nishikawa T, Maemura K: Histopathological and genetic differences between polypoid and non-polypoid submucosal colorectal carcinoma. World J Gastroenterol; 2007 Apr 14;13(14):2048-52
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  • [Title] Histopathological and genetic differences between polypoid and non-polypoid submucosal colorectal carcinoma.
  • AIM: To investigate the histopathological and genetic differences between polypoid growth (PG) and non-polypoid growth (NPG) submucosal invasive colorectal carcinoma (CRC).
  • [MeSH-major] Carcinoma / genetics. Carcinoma / pathology. Cell Proliferation. Colorectal Neoplasms / genetics. Colorectal Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / genetics. Adenocarcinoma / pathology. Adenoma / diagnosis. Adenoma / genetics. Adenoma / pathology. Diagnosis, Differential. Disease Progression. Gene Expression Regulation, Neoplastic. Humans. Lymphatic Metastasis / genetics. Lymphatic Metastasis / pathology. Mutation / genetics. Polymorphism, Single-Stranded Conformational. Proto-Oncogene Proteins p21(ras) / genetics. Proto-Oncogene Proteins p21(ras) / metabolism. Tumor Suppressor Protein p53 / genetics. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 17465446.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras)
  • [Other-IDs] NLM/ PMC4319123
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3. Ogawa T, Yoshida T, Tsuruta T, Saigenji K, Okayasu I: Genetic instability on chromosome 17 in the epithelium of non-polypoid colorectal carcinomas compared to polypoid lesions. Cancer Sci; 2006 Dec;97(12):1335-42
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  • [Title] Genetic instability on chromosome 17 in the epithelium of non-polypoid colorectal carcinomas compared to polypoid lesions.
  • Early colorectal carcinomas (submucosal invasive adenocarcinomas) can be classified into polypoid growth carcinoma (PG-Ca) and non-polypoid growth carcinoma (NPG-Ca) types, the latter transforming more rapidly to advanced carcinoma.
  • These results suggest that epithelial and stromal MSI of Chr.17 markers contributes more to carcinogenesis in NPG-Ca, whereas stromal genetic instability might be necessary for the development of both types of colorectal carcinoma.
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Adenocarcinoma / genetics. Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenoma / genetics. Adenoma / metabolism. Adenoma / pathology. Carrier Proteins / genetics. Cell Differentiation. DNA Methylation. DNA, Neoplasm / genetics. DNA, Neoplasm / metabolism. Female. Gene Expression Regulation, Neoplastic. Humans. Immunoenzyme Techniques. Loss of Heterozygosity. Lymphatic Metastasis / pathology. Male. Microsatellite Repeats. Middle Aged. Mucous Membrane / metabolism. Mucous Membrane / pathology. MutS Homolog 2 Protein / genetics. Nuclear Proteins / genetics. O(6)-Methylguanine-DNA Methyltransferase / genetics. Polymerase Chain Reaction. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 17032312.001).
  • [ISSN] 1347-9032
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / DNA, Neoplasm; 0 / MLH1 protein, human; 0 / Nuclear Proteins; 0 / Tumor Suppressor Protein p53; EC 2.1.1.63 / O(6)-Methylguanine-DNA Methyltransferase; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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4. Hasan N, Pollack A, Cho I: Infectious causes of colorectal cancer. Infect Dis Clin North Am; 2010 Dec;24(4):1019-39, x
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  • Our understanding of the pathogenesis of colorectal cancer, from the precursor adenomatous polyp to adenocarcinoma, has evolved rapidly.
  • [MeSH-major] Adenoma / etiology. Bacterial Infections / complications. Carcinoma / etiology. Colorectal Neoplasms / etiology. Virus Diseases / complications

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  • [Copyright] Published by Elsevier Inc.
  • (PMID = 20937463.001).
  • [ISSN] 1557-9824
  • [Journal-full-title] Infectious disease clinics of North America
  • [ISO-abbreviation] Infect. Dis. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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5. Guebel DV, Torres NV: A computer model of oxygen dynamics in human colon mucosa: implications in normal physiology and early tumor development. J Theor Biol; 2008 Feb 7;250(3):389-409
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  • In an extended model, simulation of an aberrant crypt focus (ACF)--the earliest stage in the adenomatous polyp-carcinoma sequence--showed instead that respiratory activity decreased when the capillary array symmetry is disrupted due to the ACF growth.

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  • (PMID = 18022199.001).
  • [ISSN] 1095-8541
  • [Journal-full-title] Journal of theoretical biology
  • [ISO-abbreviation] J. Theor. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] S88TT14065 / Oxygen
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6. Hörkkö TT, Tuppurainen K, George SM, Jernvall P, Karttunen TJ, Mäkinen MJ: Thyroid hormone receptor beta1 in normal colon and colorectal cancer-association with differentiation, polypoid growth type and K-ras mutations. Int J Cancer; 2006 Apr 1;118(7):1653-9
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  • [Title] Thyroid hormone receptor beta1 in normal colon and colorectal cancer-association with differentiation, polypoid growth type and K-ras mutations.
  • The precursors for colorectal cancer include polypoid (conventional), flat and serrated adenomas.
  • Polypoid growth in polypoid adenomas and serrated adenomas is associated with K-ras mutations.
  • The regulation of polypoid or nonpolypoid growth is not well known, but could be related to trophic stimuli, such as thyroid hormones.
  • One hundred fourteen colorectal carcinoma specimens were evaluated for TRbeta1.
  • Normal mucosa, adjacent adenomatous component (N = 46) and lymph node metastases (N = 28) were analysed when present, and the results were confirmed by Western blot analysis in selected cases.
  • TRbeta1 was associated with polypoid growth, presence of K-ras mutations and also with a higher WHO histological grade and advanced Dukes' stage.
  • [MeSH-major] Adenocarcinoma / physiopathology. Adenoma / physiopathology. Colorectal Neoplasms / physiopathology. Genes, ras. Thyroid Hormone Receptors beta / biosynthesis. Thyroid Hormone Receptors beta / physiology

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  • (PMID = 16231318.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Thyroid Hormone Receptors beta
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7. Simmen FA, Frank JA, Wu X, Xiao R, Hennings LJ, Prior RL: Lack of efficacy of blueberry in nutritional prevention of azoxymethane-initiated cancers of rat small intestine and colon. BMC Gastroenterol; 2009 Sep 16;9:67
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  • There was a tendency (0.1 > P > 0.05) for fewer adenocarcinomas (relative to total of adenomatous polyps plus adenocarcinomas) in colons of female than male tumor-bearing rats; in small intestine, this gender difference was significant (P < 0.05).
  • BB favored (P < 0.05) fewer adenocarcinomas and more adenomatous polyps (as a proportion of total tumor number) in female rat small intestine.
  • Data indicate the potential for slowing tumor progression (adenomatous polyp to adenocarcinoma) by BB.

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  • (PMID = 19758446.001).
  • [ISSN] 1471-230X
  • [Journal-full-title] BMC gastroenterology
  • [ISO-abbreviation] BMC Gastroenterol
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CB / N02-CB-07008
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / C-Peptide; MO0N1J0SEN / Azoxymethane
  • [Other-IDs] NLM/ PMC2752457
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8. Lin WP, Su MY, Ho YP, Hsu CM, Lin CJ, Chiu CT, Chen PC: Treating colorectal polypoid neoplasms during a colonoscopy. Chang Gung Med J; 2005 Nov;28(11):801-7
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  • [Title] Treating colorectal polypoid neoplasms during a colonoscopy.
  • BACKGROUND: To evaluate the efficacy and outcomes of endoscopic treatment for colorectal polypoid neoplastic lesions.
  • METHODS: From September 1999 to May 2003, 11,447 consecutive colonoscopic examinations were performed in 9864 patients, totaling 5355 endoscopic polypectomies for colorectal polypoid neoplasms.
  • For the adenocarcinoma group, 24 instances involved submucosal invasion or an unclear resection margin, and these patients received a further operation, while 11 surgical specimens disclosed no residual tumors.
  • CONCLUSIONS: To lower the incidence of and mortality from colorectal cancer, endoscopic polypectomy for colorectal polypoid neoplasms is an effective and safe procedure.
  • [MeSH-major] Adenocarcinoma / surgery. Adenoma / surgery. Colonic Polyps / surgery. Colonoscopy. Colorectal Neoplasms / surgery

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  • (PMID = 16422187.001).
  • [ISSN] 2072-0939
  • [Journal-full-title] Chang Gung medical journal
  • [ISO-abbreviation] Chang Gung Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China (Republic : 1949- )
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9. Hattori M, Inui K, Yoshino J, Miyoshi H, Okushima K, Nakamura Y, Naito T, Imaeda Y, Horibe Y, Hattori T, Nakazawa S: [Usefulness of contrast-enhanced ultrasonography in the differential diagnosis of polypoid gallbladder lesions]. Nihon Shokakibyo Gakkai Zasshi; 2007 Jun;104(6):790-8
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  • [Title] [Usefulness of contrast-enhanced ultrasonography in the differential diagnosis of polypoid gallbladder lesions].
  • We investigated the usefulness of contrast-enhanced ultrasonography for differential diagnosis of polypoid gallbladder lesions in 60 patients, consisting of gallbladder carcinoma in 20, adenoma in 2, benign polyp in 29, and adenomyomatosis in 9, comparing contrast enhancement patterns with pathologic findings.
  • In gallbladder carcinoma, the TIC rose from no contrast to early-phase contrast sooner than in other diseases.
  • In adenocarcinoma, high-intensity values persisted at 120 sec.
  • Ultrasonographic contrast enhancement patterns show characteristic associations with pathologic findings and serve as valuable adjuncts in the diagnosis of gallbladder diseases.
  • [MeSH-major] Adenoma / ultrasonography. Gallbladder Neoplasms / ultrasonography. Polyps / ultrasonography. Ultrasonography, Doppler / methods
  • [MeSH-minor] Adenomyoma / pathology. Adenomyoma / ultrasonography. Contrast Media / administration & dosage. Diagnosis, Differential. Humans. Neoplasm Staging

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  • (PMID = 17548945.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Contrast Media
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10. Koga Y, Yao T, Hirahashi M, Kumashiro Y, Ohji Y, Yamada T, Tanaka M, Tsuneyoshi M: Flat adenoma-carcinoma sequence with high-malignancy potential as demonstrated by CD10 and beta-catenin expression: a different pathway from the polypoid adenoma-carcinoma sequence. Histopathology; 2008 Apr;52(5):569-77
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  • [Title] Flat adenoma-carcinoma sequence with high-malignancy potential as demonstrated by CD10 and beta-catenin expression: a different pathway from the polypoid adenoma-carcinoma sequence.
  • The aim was to examine phenotypic expression in colorectal neoplasia and to elucidate changes in such expression through the adenoma-carcinoma sequence.
  • METHODS AND RESULTS: We examined the expression of various proteins immunohistochemically in 111 flat [non-polypoid growth (NPG)] colorectal neoplasms, categorized into 28 low-grade (NPG-LGN), 44 high-grades (NPG-HGN) and 39 cases of invasive neoplasia (NPG-IN), as well as in 96 polypoid [polypoid growth (PG)] neoplasms, categorized into 26 PG-LGN, 39 PG-HGN and 31 PG-IN according to the Vienna classification.
  • CONCLUSIONS: From the viewpoint of the expression of CD10 and beta-catenin, it would appear that NPG-LGN differs significantly from PG-LGN, thereby indicating that NPG-LGN is a precursor of CD10+ carcinoma.
  • It is important to ensure that NPG neoplasia is not overlooked if cases of CD10+ carcinoma are to be detected at an early stage.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Colonic Polyps / pathology. Colorectal Neoplasms / pathology. Neprilysin / metabolism. beta Catenin / metabolism
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Cell Nucleus / metabolism. Cell Nucleus / pathology. Disease Progression. Early Diagnosis. Female. Humans. Immunohistochemistry. Intestinal Mucosa / metabolism. Intestinal Mucosa / pathology. Male. Neoplasm Invasiveness

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  • (PMID = 18370954.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CTNNB1 protein, human; 0 / beta Catenin; EC 3.4.24.11 / Neprilysin
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11. Noda H, Kato Y, Yoshikawa H, Arai M, Togashi K, Nagai H, Konishi F, Miki Y: Frequent involvement of ras-signalling pathways in both polypoid-type and flat-type early-stage colorectal cancers. J Exp Clin Cancer Res; 2006 Jun;25(2):235-42
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  • [Title] Frequent involvement of ras-signalling pathways in both polypoid-type and flat-type early-stage colorectal cancers.
  • The development of colorectal neoplasms proceeds mainly via the adenoma-carcinoma sequence.
  • The authors studied mutations of the BRAF and K-ras genes, RASSF1A promoter methylation, and p53 overexpression in 43 polypoid-type and 30 flat-type early-stage colorectal cancers.
  • All BRAF mutation-positive tumors were flat-type cancers, not associated with coexisting adenoma or p53 overexpression.
  • RASSF1A promoter methylation was detected in 12 out of 73 tumors (16.4%), and the proportion of positive cases was similar in polypoid-type and flat-type cancers.
  • BRAF mutations are involved only in flat-type cancers, whereas RASSF1A promoter methylation is involved in both polypoid-type and flat-type cancers.
  • Thus, BRAF mutations most likely participate in de novo colorectal carcinogenesis, K-ras mutations in the adenoma-carcinoma sequence of colorectal carcinogenesis, and RASSF1A promoter methylation in both cascades.
  • [MeSH-major] Adenocarcinoma / genetics. Colorectal Neoplasms / genetics. Genes, ras / genetics. Proto-Oncogene Proteins B-raf / genetics. Signal Transduction. Tumor Suppressor Proteins / genetics

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  • (PMID = 16918136.001).
  • [ISSN] 0392-9078
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / RASSF1 protein, human; 0 / Tumor Suppressor Protein p53; 0 / Tumor Suppressor Proteins; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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12. Cimitan A, Burza A, Basile U, Saputo S, Mingazzini P, Stipa F: [Local excision of giant rectal polypoid neoplasms]. Chir Ital; 2008 May-Jun;60(3):345-53

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  • [Title] [Local excision of giant rectal polypoid neoplasms].
  • In 3 patients with a preoperative diagnosis of severe dysplasia (Tis) final pathology showed adenoma and for this reason they were included in our study group.
  • Twenty-five (49%) patients had a definitive diagnosis of adenocarcinoma: in situ (pTis) in 22 patients (88%), pT1 in 2 patients (8%) and pT2 in 1 patient (4%).
  • In 26 patients (51%) the diagnosis was adenoma.
  • Giant sessile polypoid lesions localized in the middle and upper rectum are best treated with T.E.M., while Parks technique is a good option in lower rectal tumours.

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  • (PMID = 18709772.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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13. Zhang ZY, Zhao ZR, Jiang L, Li JC, Gao YM, Cui DS, Wang CJ, Schneider J, Wang MW, Sun XF: Nup88 expression in normal mucosa, adenoma, primary adenocarcinoma and lymph node metastasis in the colorectum. Tumour Biol; 2007;28(2):93-9
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  • [Title] Nup88 expression in normal mucosa, adenoma, primary adenocarcinoma and lymph node metastasis in the colorectum.
  • OBJECTIVES: It was the aim of this study to investigate Nup88 expression in normal colorectal mucosa, adenoma, adenocarcinoma and lymph node metastasis, as well as the relationship between Nup88 expression and clinicopathological features.
  • The frequency of strong Nup88 expression was increased from normal mucosa or adenoma to primary tumour and lymph node metastasis (p < 0.0001).
  • There was no significant difference in the expression between normal mucosa and adenoma (p = 0.41).
  • The frequency of strong Nup88 expression was higher in ulcerated tumours (40%) than in polypoid/large fungating tumours (23%; p = 0.048).
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. Colorectal Neoplasms / metabolism. Intestinal Mucosa / metabolism. Nuclear Pore Complex Proteins / metabolism

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  • [Copyright] Copyright (c) 2007 S. Karger AG, Basel.
  • (PMID = 17264541.001).
  • [ISSN] 1010-4283
  • [Journal-full-title] Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
  • [ISO-abbreviation] Tumour Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / NUP88 protein, human; 0 / Nuclear Pore Complex Proteins
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14. Nagaike K, Chijiiwa K, Hiyoshi M, Ohuchida J, Kataoka H: Main-duct intraductal papillary mucinous adenoma of the pancreas with a large mural nodule. Int J Clin Oncol; 2007 Oct;12(5):388-91
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  • [Title] Main-duct intraductal papillary mucinous adenoma of the pancreas with a large mural nodule.
  • The resected intraductal tumor appeared polypoid with a broad stalk and comprised a proliferation of mucin-containing columnar epithelial cells with papillary structures without malignant features.
  • The final diagnosis was intraductal papillary mucinous adenoma of the pancreas.
  • The size of the mural nodule and the final diagnosis in this case suggest that the introduction of a novel molecular-biological approach might be necessary for the precise preoperative diagnosis of main-duct IPMN and adequate surgical treatment.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Carcinoma, Pancreatic Ductal / pathology. Cystadenoma, Mucinous / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 17929124.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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15. Chetty R, Serra S: Intraductal tubular adenoma (pyloric gland-type) of the pancreas: a reappraisal and possible relationship with gastric-type intraductal papillary mucinous neoplasm. Histopathology; 2009 Sep;55(3):270-6
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  • [Title] Intraductal tubular adenoma (pyloric gland-type) of the pancreas: a reappraisal and possible relationship with gastric-type intraductal papillary mucinous neoplasm.
  • AIMS: Intraductal tubular adenoma (ITA) is an uncommon intraluminal polypoid lesion that occurs in the main pancreatic duct and involves the main pancreatic duct in the region of head or body.
  • ITA could represent a localized, polypoid form of gastric-type IPMN.It is a benign lesion with no evidence of invasion and no direct tumour-related deaths.
  • Its relationship to intraductal tubular carcinoma remains to be elucidated.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Papillary / pathology. Adenoma / pathology. Carcinoma in Situ / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / pathology

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  • [CommentIn] Histopathology. 2010 Jun;56(7):968-9; author reply 969 [20636797.001]
  • (PMID = 19723141.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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16. Takahashi T, Ando T, Kabeshima Y, Kawakubo H, Shito M, Sugiura H, Omori T: Borderline cases between benignancy and malignancy of the duodenum diagnosed successfully by endoscopic submucosal dissection. Scand J Gastroenterol; 2009;44(11):1377-83
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  • An incision was made around the lesion using a long-type needle knife and the isolated lesion was resected completely "en bloc".
  • Gross examination showed three flat, elevated lesions and one polypoid lesion.
  • CONCLUSIONS. Since tissue obtained from endoscopic biopsies can sometimes prove difficult for definitive histological diagnosis, ESD may play an important role in the management of cases appearing to border on malignancy.
  • In addition, ESD allows for minimally invasive treatment without sacrificing the possibility of cure for duodenal carcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma / diagnosis. Dissection / methods. Duodenal Neoplasms / diagnosis. Endoscopy, Gastrointestinal / methods. Intestinal Mucosa / pathology
  • [MeSH-minor] Aged. Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male

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  • (PMID = 19821793.001).
  • [ISSN] 1502-7708
  • [Journal-full-title] Scandinavian journal of gastroenterology
  • [ISO-abbreviation] Scand. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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17. Toth B, Coles M, Lynch J: Effects of VPS extract of Coriolus versicolor on cancer of the large intestine using a serial sacrifice technique. In Vivo; 2006 May-Jun;20(3):341-6
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  • Histopathologically, the tumors were diagnosed as polypoid adenomas and adenocarcinomas of the cecum, colon and rectum.
  • [MeSH-minor] Adenocarcinoma / chemically induced. Adenocarcinoma / pathology. Adenoma / chemically induced. Adenoma / pathology. Animals. Cecal Neoplasms / chemically induced. Cecal Neoplasms / pathology. Colonic Neoplasms / chemically induced. Colonic Neoplasms / pathology. Female. Injections, Subcutaneous. Mice. Rectal Neoplasms / chemically induced. Rectal Neoplasms / pathology. Survival Analysis. Time Factors

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  • (PMID = 16724667.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Grant] United States / NCCIH NIH HHS / AT / 1R21 AT001739
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Plant Extracts; IX068S9745 / 1,2-Dimethylhydrazine
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18. Burbos N, Giarenis I, Ostrowski J, Lonsdale R, Nieto JJ: Synchronous diagnosis of multiple tumours in a postmenopausal woman. Arch Gynecol Obstet; 2009 Oct;280(4):627-30

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronous diagnosis of multiple tumours in a postmenopausal woman.
  • Histopathology showed a Grade 3 endometrial adenocarcinoma.
  • Both ovaries were completely replaced by partially necrotic poorly differentiated endometrioid adenocarcinoma.
  • Small deposits of metastatic adenocarcinoma were seen within the omentum.
  • A large polypoid tumour within the right colon was a tubulo-villous adenoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma / diagnosis. Colonic Neoplasms / diagnosis. Genital Neoplasms, Female / diagnosis. Liposarcoma / diagnosis. Neoplasms, Multiple Primary / diagnosis. Retroperitoneal Neoplasms / diagnosis

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  • (PMID = 19198863.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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19. Gheorghe C, Iacob R, Dumbrava M, Becheanu G, Ionescu M: Confocal laser endomicroscopy and ultrasound endoscopy during the same endoscopic session for diagnosis and staging of gastric neoplastic lesions. Chirurgia (Bucur); 2009 Jan-Feb;104(1):17-24
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  • [Title] Confocal laser endomicroscopy and ultrasound endoscopy during the same endoscopic session for diagnosis and staging of gastric neoplastic lesions.
  • The indication of CLE/EUS exploration was the presence of a gastric polypoid lesion in 37% of cases, atypical gastric ulcer in 27% of patients, gastric lymphoma 18%, suspicion of gastric cancer recurrence after resection 9% and infiltrating type gastric cancer 9%.
  • Histological assessment after targeted biopsy has established the diagnosis of gastric adenocarcinoma in 55% of cases, gastric lymphoma in 18% of cases, gastric adenoma, gastric GIST and gastric foveolar hyperplasia in 9% of cases respectively.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy. Diagnosis, Differential. Female. Gastric Mucosa / pathology. Gastric Mucosa / ultrasonography. Humans. Male. Middle Aged. Neoplasm Staging. Pilot Projects. Reproducibility of Results. Sensitivity and Specificity

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  • (PMID = 19388564.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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20. Zurac S, Micu G, Bastian A, Grămadă E, Lavric L, Andrei R, Stăniceanu F, Voiosu R, Croitoru A: Malignancy and overdiagnosis of malignancy in Peutz Jeghers polyposis. Rom J Intern Med; 2008;46(2):179-84
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  • We analyzed different degrees of dysplastic changes, epithelial intussusception, association with other types of polypoid lesions and other various aspects possibly related with disease progression.
  • Two of these cases were related (mother and daughter); both of them were operated in another hospital for small bowel tumors with a subsequent diagnosis of adenocarcinoma.
  • The daughter (28 years old) was referred to our hospital for endoscopic follow-up; a small polyp of the transverse large bowel was excised by colonoscopy with a histopathologic diagnosis of PJ polyp; a careful histopathologic reevaluation of both specimens of enterectomy (slides and paraffin blocks) revealed an overdiagnosis of cancer due to the epithelial cystic dilatation and pseudoinvasion in both patients.
  • The other case showed diagnostic changes of PJS and also various aspects of adenomatous polyps some of them with mild and moderate dysplastic changes.
  • When a PJ polyp is diagnosed, the possibility of pseudoinvasion should be kept in mind, in order to avoid overdiagnosis of malignancy; also, due to the fact that the malignant transformation of a PJ polyp is still on debate (hamartoma-dysplasia-carcinoma sequence versus malignant transformation of an adenomatous aria of a hamartoma versus coincidental association of a digestive cancer due to genetic aberrations of PJS), all the other associated microscopic aspects of the lesion should be carefully analyzed.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Intestinal Neoplasms / pathology. Intestinal Polyps / pathology. Peutz-Jeghers Syndrome / diagnosis. Stomach Neoplasms / pathology

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  • (PMID = 19284092.001).
  • [ISSN] 1220-4749
  • [Journal-full-title] Romanian journal of internal medicine = Revue roumaine de médecine interne
  • [ISO-abbreviation] Rom J Intern Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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21. Rocco A, Caruso R, Toracchio S, Rigoli L, Verginelli F, Catalano T, Neri M, Curia MC, Ottini L, Agnese V, Bazan V, Russo A, Pantuso G, Colucci G, Mariani-Costantini R, Nardone G: Gastric adenomas: relationship between clinicopathological findings, Helicobacter pylori infection, APC mutations and COX-2 expression. Ann Oncol; 2006 Jun;17 Suppl 7:vii103-8
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  • Gastric adenomas are rare neoplastic growths characterized by localized polypoid proliferations of dysplastic epithelium that tend to progress to infiltrating adenocarcinoma.
  • In this study we investigated, in a series of gastric adenoma specimens from an area at high risk of gastric cancer, the relationship between clinicopathological characteristics of adenoma and Helicobacter pylori infection, APC mutational status, and COX-2 and the down-stream enzyme mPGES1 expression.
  • Pathogenetic mutations of MCR region (codons 1269-1589) of the APC gene were detected only in one case corresponding to a single, small size, low grade, H. pylori-negative adenoma.
  • Both were overexpressed in 79% of cases showing a relationship with high-grade dysplasia, size >10 mm and presence of a synchronous carcinoma.
  • In conclusion, COX-2 may play a key role in the development and progression of gastric adenoma and could be an attractive target in the management of gastric adenoma at major risk of cancer development.

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  • (PMID = 16760271.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 1.14.99.1 / Cyclooxygenase 2; EC 5.3.- / Intramolecular Oxidoreductases; EC 5.3.99.3 / prostaglandin-E synthase
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22. Wasilewicz MP, Kołodziej B, Bojułko T, Kaczmarczyk M, Sulzyc-Bielicka V, Bielicki D, Ciepiela K: Overexpression of 5-lipoxygenase in sporadic colonic adenomas and a possible new aspect of colon carcinogenesis. Int J Colorectal Dis; 2010 Sep;25(9):1079-85
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  • METHODS: A total of 111 patients were examined and 120 histologically different colonic adenomas analyzed (including four cases of intramucosal adenocarcinoma in a polyp).
  • RESULTS: There was a significant correlation between high 5-LOX expression and patient age, increased polyp size, high grade of intraepithelial neoplasia, villous and tubulovillous adenoma, and histological epithelial localization.
  • CONCLUSIONS: We observed a strong positive correlation between 5-LOX overexpression and the appearance of typical high-risk factors for malignant transformation in adenomatous polyps.
  • [MeSH-major] Adenoma / enzymology. Adenoma / pathology. Arachidonate 5-Lipoxygenase / metabolism. Colonic Neoplasms / enzymology. Colonic Neoplasms / pathology. Precancerous Conditions / enzymology. Precancerous Conditions / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma in Situ / enzymology. Carcinoma in Situ / pathology. Colonic Polyps / enzymology. Colonic Polyps / pathology. Female. Humans. Male. Middle Aged

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  • (PMID = 20549218.001).
  • [ISSN] 1432-1262
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 1.13.11.34 / Arachidonate 5-Lipoxygenase
  • [Other-IDs] NLM/ PMC2912725
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23. Katabi N: Neoplasia of gallbladder and biliary epithelium. Arch Pathol Lab Med; 2010 Nov;134(11):1621-7
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  • CONTEXT: Diagnosis of biliary neoplasia can be challenging but is essential for the appropriate clinical management of patients.
  • Therefore, it is important to recognize the morphologic features of the biliary neoplasms to report a correct diagnosis. OBJECTIVES:.
  • (1) To discuss the differential diagnosis of dysplasia in the gallbladder and differentiate dysplasia from reactive atypia and invasive carcinoma, (2) review the histologic features of adenoma and polypoid biliary lesions, (3) highlight the differential diagnosis of adenocarcinoma in liver biopsy, and (4) discuss the differential diagnosis of atypical biliary glandular lesions.
  • Careful examination of the histologic features of these lesions and familiarity with their morphology can help to achieve the correct diagnosis.
  • [MeSH-major] Adenoma / pathology. Bile Duct Neoplasms / pathology. Carcinoma / pathology. Gallbladder Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Metaplasia / pathology

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  • (PMID = 21043815.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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24. Hameed O, Humphrey PA: Pseudoneoplastic mimics of prostate and bladder carcinomas. Arch Pathol Lab Med; 2010 Mar;134(3):427-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CONTEXT: The differential diagnoses of prostatic carcinoma and bladder epithelial neoplasms include several histologic mimics that should be known to avoid misdiagnosis.
  • OBJECTIVE: To discuss pseudoneoplastic lesions of the prostate and bladder that could potentially be confused with prostatic carcinoma and bladder epithelial neoplasms, respectively, with specific focus on their distinguishing histopathologic features.
  • CONCLUSIONS: Pseudoneoplastic lesions in the prostate include those of prostatic epithelial origin, the most common being atrophy, adenosis (atypical adenomatous hyperplasia), basal cell hyperplasia, and crowded benign glands, as well as those of nonprostatic origin, such as seminal vesicle epithelium.
  • Such lesions often mimic lower-grade prostatic adenocarcinoma, whereas others, such as clear cell cribriform hyperplasia and granulomatous prostatitis, for example, are in the differential diagnosis of Gleason adenocarcinoma, Gleason grade 4 or 5.
  • Pseudoneoplastic lesions of the urinary bladder include lesions that could potentially be confused with urothelial carcinoma in situ, such as reactive urothelial atypia, and others, such as polypoid/papillary cystitis, where papillary urothelial neoplasms are the main differential diagnostic concern.
  • Several lesions can mimic invasive urothelial carcinoma, including pseudocarcinomatous hyperplasia, von Brunn nests, and nephrogenic adenoma.
  • [MeSH-major] Granuloma, Plasma Cell / diagnosis. Prostatic Diseases / diagnosis. Urinary Bladder Diseases / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Prostatic Neoplasms / classification. Prostatic Neoplasms / diagnosis. Urinary Bladder Neoplasms / classification. Urinary Bladder Neoplasms / diagnosis

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  • (PMID = 20196670.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 83
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25. Ohno E, Hirooka Y, Itoh A, Ishigami M, Katano Y, Ohmiya N, Niwa Y, Goto H: Intraductal papillary mucinous neoplasms of the pancreas: differentiation of malignant and benign tumors by endoscopic ultrasound findings of mural nodules. Ann Surg; 2009 Apr;249(4):628-34
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  • Twelve clinicopathological variables and CE-EUS morphologic findings were assessed.Mural nodules defined as blood flow supplied protrusions were classified into 4 types: type I: low papillary nodule, type II: polypoid nodule, type III:papillary nodule, and type IV: invasive nodule.
  • RESULTS: Forty-two, 26, 16, and 3 were pathologically diagnosed as adenoma,noninvasive carcinoma, invasive IPMNs, and coexistent invasive ductal cancer, respectively.
  • The diagnosis of IPMNs with types III or IV mural nodule as malignant resulted in a sensitivity of 60%, specificity of 92.9%, and accuracy of 75.9%.
  • CONCLUSIONS: In conclusion, new morphologic criteria were useful to identify the malignant potentials of IPMNs.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Pancreatic Ductal / ultrasonography. Endosonography / methods. Neoplasm Invasiveness / pathology. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / ultrasonography
  • [MeSH-minor] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / ultrasonography. Aged. Aged, 80 and over. Analysis of Variance. Biopsy, Fine-Needle. Cohort Studies. Confidence Intervals. Contrast Media. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Logistic Models. Male. Mucous Membrane / pathology. Mucous Membrane / ultrasonography. Multivariate Analysis. Neoplasm Staging. Odds Ratio. Probability. Sensitivity and Specificity

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  • (PMID = 19300203.001).
  • [ISSN] 1528-1140
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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26. Croitoru L, Trifan A, Maxim MR, Girleanu I, Hulub A, Dimache M, Stanciu C: Colonoscopic screening of asymptomatic first-degree relatives of colorectal cancer patients. Rev Med Chir Soc Med Nat Iasi; 2010 Jul-Sep;114(3):683-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: Thirty colorectal lesions were found in 17 individuals: two (6.6%) had adenocarcinomas, and remaining 15 patients had 28 polypoid lesions: 14 (46.6%) adenomas, 5 (16.6%) tubulovillous adenomas, 3 (10%) adenomas with high grade dysplasia and 6 (20%) had hyperplasic polyps.
  • [MeSH-major] Adenocarcinoma / diagnosis. Colonoscopy. Colorectal Neoplasms / diagnosis. Nuclear Family
  • [MeSH-minor] Adenoma / diagnosis. Adult. Aged. Feasibility Studies. Female. Genetic Predisposition to Disease. Humans. Male. Mass Screening. Middle Aged. Polyps / diagnosis. Predictive Value of Tests. Prevalence. Risk Assessment. Romania / epidemiology

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  • (PMID = 21235115.001).
  • [ISSN] 0048-7848
  • [Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
  • [ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Romania
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27. Gualco G, Reissenweber N, Cliché I, Bacchi CE: Flat elevated lesions of the colon and rectum: a spectrum of neoplastic and nonneoplastic entities. Ann Diagn Pathol; 2006 Dec;10(6):333-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The aim of this prospective study is to establish the frequency and the type (neoplastic and nonneoplastic) lesions defined endoscopically as flat elevated lesion (FEL) in the colon and rectum, as well as to compare flat adenomas (FAs) to polypoid lesions of the same size with morphometric and immunohistochemical analysis.
  • In neoplastic lesions, the following parameters were evaluated to compare FAs with polypoid lesions: morphometric studies with Index of Structural Atypia (ISA) and Stratification Index (SI), evaluation of cellular proliferation with label index of Ki-67, and expression of p53 protein.
  • Among the FAs, there were a percentage of high-grade (severe dysplasia) significantly more frequent than observed in polypoid lesions (16.7% vs 2.6%).
  • Following the endoscopic criteria of FELs, nonneoplastic lesions predominated over the adenomatous lesions, demonstrating that FELs and FAs are not homologous terms.
  • The frequency of high-grade dysplasia was significantly more elevated in the adenomatous FELs than in polypoid adenomas.
  • The ISA, SI, p53 expression, and Ki-67 label index were helpful in differentiating adenomatous FELs from polypoid lesions.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Colonic Neoplasms / pathology. Endoscopy, Gastrointestinal / methods. Rectal Neoplasms / pathology

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  • (PMID = 17126250.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
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28. Ramos O Jr, Boguszewski CL, Teixeira S, De Bem R, Parolim B, Prolla JC: Performance of computed tomographic colonography for the screening of colorectal polyp in acromegalic patients: a prospective study. Arq Gastroenterol; 2009 Apr-Jun;46(2):90-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Performance of computed tomographic colonography for the screening of colorectal polyp in acromegalic patients: a prospective study.
  • Computed tomographic colonography, also known as virtual colonoscopy, is an innovative and secure technology which is revolutionizing the diagnosis of colon and rectum neoplasias.
  • In Phase II ('per polyp'), out of the 21 acromegalic patients included in this study, 12 presented normal findings at conventional colonoscopy.
  • The histological analysis of resected lesions revealed 12 tubular adenomas, 6 hyperplastic polyps and 1 colonic tubulo-villous adenoma with an adenocarcinoma focus.
  • Moreover, computed tomographic colonography presented good sensitivity, specificity and accuracy for the identification of acromegalic patients with polyps of any size and better results in the diagnosis of large polyps, when they were compared to small polypoid lesions.

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  • [CommentIn] Arq Gastroenterol. 2009 Apr-Jun;46(2):85-6 [19578605.001]
  • (PMID = 19578607.001).
  • [ISSN] 1678-4219
  • [Journal-full-title] Arquivos de gastroenterologia
  • [ISO-abbreviation] Arq Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
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29. Toth B, Coles M: Inhibition of large intestinal cancers by celecoxib using a serial sacrifice technique. In Vivo; 2006 Jul-Aug;20(4):453-7
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  • Histopathologically, the tumors were diagnosed as polypoid adenomas and adenocarcinomas of the cecum, colon and rectum.
  • [MeSH-minor] 1,2-Dimethylhydrazine / administration & dosage. 1,2-Dimethylhydrazine / pharmacology. Adenocarcinoma / chemically induced. Adenocarcinoma / pathology. Adenoma / chemically induced. Adenoma / pathology. Administration, Oral. Animals. Animals, Outbred Strains. Anti-Inflammatory Agents, Non-Steroidal / administration & dosage. Carcinogens / administration & dosage. Carcinogens / pharmacology. Celecoxib. Female. Incidence. Injections, Subcutaneous. Mice. Survival Rate. Time Factors

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  • (PMID = 16900774.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Grant] United States / NCCIH NIH HHS / AT / 1R21 AT001739
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Carcinogens; 0 / Cyclooxygenase Inhibitors; 0 / Pyrazoles; 0 / Sulfonamides; IX068S9745 / 1,2-Dimethylhydrazine; JCX84Q7J1L / Celecoxib
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