[X] Close
You are about to erase all the values you have customized, search history, page format, etc.
Click here to RESET all values       Click here to GO BACK without resetting any value
Items 1 to 33 of about 33
1. Balbinotti RA, Ribeiro U Jr, Sakai P, Safatle-Ribeiro AV, Balbinotti SS, Scapulatempo C, Alves VA, Corbett CE, Carrilho FJ: hMLH1, hMSH2 and cyclooxygenase-2 (cox-2) in sporadic colorectal polyps. Anticancer Res; 2007 Nov-Dec;27(6C):4465-71
MedlinePlus Health Information. consumer health - Colonic Polyps.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] hMLH1, hMSH2 and cyclooxygenase-2 (cox-2) in sporadic colorectal polyps.
  • BACKGROUND: Colorectal adenomatous polyps are known as premalignant lesions.
  • Cox-2 is an inducible enzyme that regulates prostaglandin synthesis and it is overexpressed at sites of inflammation, in colorectal adenomatous polyps and cancer.
  • The aim of this study was to evaluate the immunoexpression of hMLH1, hMSH2 and Cox-2 in polyps resected through colonoscopy, and to examine their association with clinicopathological characteristics (age, gender, location, size, histology and grade of dysplasia).
  • PATIENTS AND METHODS: One hundred and sixty-seven colonic polyps, 6 normal colonic mucosa samples, and 23 samples of colorectal adenocarcinoma were used in this study.
  • Cox-2 is overexpressed in colorectal adenomatous polyps and adenocarcinomas, and its positivity in adenomas may indicate a higher risk for multiple lesions.
  • [MeSH-major] Adaptor Proteins, Signal Transducing / biosynthesis. Colonic Polyps / metabolism. Cyclooxygenase 2 / biosynthesis. MutS Homolog 2 Protein / biosynthesis. Nuclear Proteins / biosynthesis. Precancerous Conditions / metabolism
  • [MeSH-minor] Adenocarcinoma / metabolism. Adult. Aged. Aged, 80 and over. Colorectal Neoplasms / metabolism. Female. Humans. Immunohistochemistry. Male. Middle Aged. Rectum / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18214062.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / MLH1 protein, human; 0 / Nuclear Proteins; EC 1.14.99.1 / Cyclooxygenase 2; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
  •  go-up   go-down


2. Heald B, Mester J, Rybicki L, Orloff MS, Burke CA, Eng C: Frequent gastrointestinal polyps and colorectal adenocarcinomas in a prospective series of PTEN mutation carriers. Gastroenterology; 2010 Dec;139(6):1927-33
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Frequent gastrointestinal polyps and colorectal adenocarcinomas in a prospective series of PTEN mutation carriers.
  • METHODS: Patients who met relaxed International Cowden Consortium criteria (N = 2548) or with 5 or more GI polyps, 1 or more of which was hyperplastic or hamartomatous (N = 397), were prospectively recruited.
  • RESULTS: Of 127 PTEN mutation carriers, 69 underwent 1 or more endoscopies with 64 (93%) having polyps.
  • Of the 64, half had hyperplastic polyps.
  • There were one to innumerable polyps in the colorectum, ileum, duodenum, stomach, and/or esophagus, with 24 subjects having both upper and lower GI polyps.
  • CONCLUSIONS: PTEN-associated CS should be considered a mixed polyp syndrome, with hyperplastic polyps most prevalent, with a risk of early onset colorectal cancer.
  • Routine colonoscopy should be considered in PTEN-associated CS, especially in the context of hyperplastic and/or adenomatous polyps.

  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • COS Scholar Universe. author profiles.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright © 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
  • [Cites] J Clin Endocrinol Metab. 2000 Jun;85(6):2334-8 [10852473.001]
  • [Cites] Nat Clin Pract Gastroenterol Hepatol. 2009 Mar;6(3):184-9 [19190598.001]
  • [Cites] J Med Genet. 2000 Nov;37(11):828-30 [11073535.001]
  • [Cites] Am J Hum Genet. 2003 Aug;73(2):404-11 [12844284.001]
  • [Cites] Br J Dermatol. 1975 Sep;93(3):329-36 [1191539.001]
  • [Cites] J Am Acad Dermatol. 1983 May;8(5):686-96 [6863628.001]
  • [Cites] Am J Surg Pathol. 1984 Oct;8(10):763-70 [6496844.001]
  • [Cites] Clin Genet. 1986 Mar;29(3):222-33 [3698331.001]
  • [Cites] J Am Acad Dermatol. 1986 Aug;15(2 Pt 1):294-6 [3745534.001]
  • [Cites] J Clin Gastroenterol. 1986 Oct;8(5):576-9 [3782758.001]
  • [Cites] Gastrointest Radiol. 1987;12(4):325-9 [3040507.001]
  • [Cites] J Clin Gastroenterol. 1994 Jan;18(1):42-7 [8113585.001]
  • [Cites] J Med Genet. 1995 Feb;32(2):117-9 [7760320.001]
  • [Cites] Surgery. 1995 Jul;118(1):115-7 [7604372.001]
  • [Cites] Nat Genet. 1996 May;13(1):114-6 [8673088.001]
  • [Cites] Int J Oncol. 1998 Mar;12(3):701-10 [9472113.001]
  • [Cites] Am J Gastroenterol. 2005 Feb;100(2):476-90 [15667510.001]
  • [Cites] JAMA. 2005 Nov 16;294(19):2465-73 [16287957.001]
  • [Cites] Int J Mol Med. 2006 Oct;18(4):643-7 [16964417.001]
  • [Cites] Nat Rev Cancer. 2007 Jan;7(1):35-45 [17167516.001]
  • [Cites] Nat Clin Pract Gastroenterol Hepatol. 2007 Sep;4(9):492-502 [17768394.001]
  • [Cites] Cancer Res. 2000 Jun 15;60(12):3147-51 [10866302.001]
  • (PMID = 20600018.001).
  • [ISSN] 1528-0012
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P01 CA124570; United States / NCI NIH HHS / CA / P01CA124570
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
  • [Other-IDs] NLM/ NIHMS466893; NLM/ PMC3652614
  •  go-up   go-down


3. Oh SY, Park DI, Yoo TW, Kang MS, Kim SH, Park JH, Kim HJ, Cho YK, Sohn CI, Jeon WK, Kim BI, Son BH, Yoo CH: [Is gastric cancer a new indication for surveillance colonoscopy? Colon cancer is increased in gastric cancer patients]. Korean J Gastroenterol; 2006 Mar;47(3):191-7
MedlinePlus Health Information. consumer health - Stomach Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND/AIMS: It has been reported that the risk of gastric polyp is increased in various colonic polyposis syndromes or in series of patients with sporadic colonic polyps.
  • RESULTS: In the patient group, adenomatous polyps were diagnosed in 24/105 patients (22.9%) and colorectal adenocarcinoma in 10/105 patients (9.5%).
  • In the control group, adenomatous polyps were diagnosed in 78/269 patients (29.0%) and colorectal adenocarcinoma in 2/269 patients (0.7%).
  • The incidence of colorectal adenocarcinoma between the patient group and control group showed significant differences (odds ratio 11.04, p=0.003).
  • CONCLUSIONS: The risk of colorectal adenocarcinoma increases significantly in patients with gastric cancer.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Colonoscopy. Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / secondary. Neoplasms, Multiple Primary / diagnosis. Stomach Neoplasms / pathology
  • [MeSH-minor] Adenomatous Polyps / diagnosis. Colonic Polyps / diagnosis. Female. Humans. Male. Middle Aged

  • MedlinePlus Health Information. consumer health - Colonoscopy.
  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16554672.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
  •  go-up   go-down


Advertisement
4. Young J, Jass JR: The case for a genetic predisposition to serrated neoplasia in the colorectum: hypothesis and review of the literature. Cancer Epidemiol Biomarkers Prev; 2006 Oct;15(10):1778-84
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In recent years, an alternative pathway of colorectal cancer development has been described in which serrated polyps replace the traditional adenoma as the precursor lesion.
  • Importantly, serrated polyps and a subset of colorectal cancer show largely nonoverlapping mutation profiles to those found in adenomas and the majority of colorectal cancer.
  • The two most well-characterized syndromes, familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer (Lynch syndrome), both develop via the adenoma-carcinoma pathway and together account for approximately one third of familial colorectal cancer.
  • The tendency for these lesions to be multiple, associated with smoking, and to show frequent BRAF mutation and CIMP points to a defect that may result from interactions between the environment and a weakly penetrant genetic alteration.

  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17035382.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U01 CA097735; United States / PHS HHS / / U-01-74778
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
  • [Number-of-references] 93
  •  go-up   go-down


5. Garrean S, Hering J, Saied A, Jani J, Espat NJ: Gastric adenocarcinoma arising from fundic gland polyps in a patient with familial adenomatous polyposis syndrome. Am Surg; 2008 Jan;74(1):79-83
MedlinePlus Health Information. consumer health - Stomach Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gastric adenocarcinoma arising from fundic gland polyps in a patient with familial adenomatous polyposis syndrome.
  • Familial adenomatous polyposis (FAP) is a rare hereditary syndrome characterized by multiple colorectal polyps and early development of colorectal cancer.
  • Fundic gland polyps are the most common gastric lesion in FAP.
  • In the general population, these polyps are considered benign and have no malignant potential.
  • However, in FAP patients, fundic gland polyps have been occasionally recognized as precursor lesions from which invasive cancer may develop.
  • Herein, we present a case of gastric adenocarcinoma arising from fundic gland polyps in an FAP patient.
  • [MeSH-major] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Adenomatous Polyposis Coli / pathology. Stomach Neoplasms / genetics. Stomach Neoplasms / pathology


6. Tanaka T, Kohno H, Suzuki R, Hata K, Sugie S, Niho N, Sakano K, Takahashi M, Wakabayashi K: Dextran sodium sulfate strongly promotes colorectal carcinogenesis in Apc(Min/+) mice: inflammatory stimuli by dextran sodium sulfate results in development of multiple colonic neoplasms. Int J Cancer; 2006 Jan 1;118(1):25-34
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dextran sodium sulfate strongly promotes colorectal carcinogenesis in Apc(Min/+) mice: inflammatory stimuli by dextran sodium sulfate results in development of multiple colonic neoplasms.
  • The mouse model for familial adenomatous polyposis, Apc(Min/+) mouse, contains a truncating mutation in the Apc gene and spontaneously develops numerous adenomas in the small intestine but few in the large bowel.
  • The treatment also significantly increased the number of small intestinal polyps.
  • [MeSH-major] Adenocarcinoma / chemically induced. Adenocarcinoma / genetics. Anticoagulants / toxicity. Colorectal Neoplasms / chemically induced. Colorectal Neoplasms / genetics. Dextran Sulfate / toxicity. Genes, APC. Inflammation / chemically induced

  • MedlinePlus Health Information. consumer health - Blood Thinners.
  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • KOMP Repository. gene/protein/disease-specific - KOMP Repository (subscription/membership/fee required).
  • Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 16049979.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticoagulants; 0 / beta Catenin; 9042-14-2 / Dextran Sulfate; EC 1.14.13.39 / Nitric Oxide Synthase Type II; EC 1.14.99.1 / Cyclooxygenase 2
  •  go-up   go-down


7. Cheung DY, Kim TH, Kim CW, Kim JI, Cho SH, Park SH, Han JY, Kim JK: The anatomical distribution of colorectal cancer in Korea: evaluation of the incidence of proximal and distal lesions and synchronous adenomas. Intern Med; 2008;47(19):1649-54
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We evaluated the anatomical distribution of colorectal cancer and the properties of synchronous adenomatous polyps in the Korean population which were known to be different from those in Western countries.
  • Synchronous adenomatous lesions were accompanied in 31.9% of all colorectal cancer cases.
  • [MeSH-major] Adenomatous Polyps / pathology. Colorectal Neoplasms / pathology. Neoplasms, Multiple Primary / pathology
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Adenocarcinoma, Mucinous / epidemiology. Adenocarcinoma, Mucinous / pathology. Adult. Aged. Carcinoma, Signet Ring Cell / epidemiology. Carcinoma, Signet Ring Cell / pathology. Female. Humans. Korea / epidemiology. Male. Middle Aged. Odds Ratio. Retrospective Studies. Sex Factors

  • Genetic Alliance. consumer health - Colorectal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18827411.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


8. Heiken JP: CT colonography screening: ready for prime time? Cancer Imaging; 2009;9 Spec No A:S59-62
MedlinePlus Health Information. consumer health - Colonic Polyps.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although multiple prospective randomized trials and observational studies have demonstrated that mortality from colon cancer can be reduced with screening and removal of adenomatous polyps, compliance with screening guidelines remains low.
  • Recent CT colonography (CTC) trials have shown that CTC is capable of demonstrating adenomatous polyps > or =10 mm (and in most cases > or = 6 mm) with sensitivities comparable to those for optical colonoscopy.
  • [MeSH-major] Adenocarcinoma / radiography. Adenoma / radiography. Colonic Neoplasms / radiography. Colonic Polyps / radiography. Colonography, Computed Tomographic
  • [MeSH-minor] Adenomatous Polyps / radiography. Aged. Colonoscopy / adverse effects. Expert Testimony. Humans. Insurance Coverage. Mass Screening. Medicaid. Medicare. Middle Aged. Multicenter Studies as Topic. Patient Compliance. Practice Guidelines as Topic. Randomized Controlled Trials as Topic / statistics & numerical data. Sensitivity and Specificity. United States

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] N Engl J Med. 2000 Nov 30;343(22):1603-7 [11096167.001]
  • [Cites] CA Cancer J Clin. 2009 Jul-Aug;59(4):225-49 [19474385.001]
  • [Cites] Am J Gastroenterol. 2002 Jun;97(6):1296-308 [12094842.001]
  • [Cites] J Natl Cancer Inst. 2003 Feb 5;95(3):230-6 [12569145.001]
  • [Cites] Gastroenterology. 2003 Apr;124(4):911-6 [12671887.001]
  • [Cites] Eur Radiol. 2003 Jun;13(6):1297-302 [12764645.001]
  • [Cites] N Engl J Med. 2003 Dec 4;349(23):2191-200 [14657426.001]
  • [Cites] JAMA. 2004 Apr 14;291(14):1713-9 [15082698.001]
  • [Cites] Cancer. 2004 May 15;100(10):2093-103 [15139050.001]
  • [Cites] Radiology. 2004 Aug;232(2):611-20 [15215541.001]
  • [Cites] N Engl J Med. 1992 Mar 5;326(10):653-7 [1736103.001]
  • [Cites] Lancet. 1996 Nov 30;348(9040):1467-71 [8942774.001]
  • [Cites] Lancet. 1996 Nov 30;348(9040):1472-7 [8942775.001]
  • [Cites] Am J Med. 1999 Jan 25;106(1A):7S-10S [10089107.001]
  • [Cites] Lancet. 2005 Jan 22-28;365(9456):305-11 [15664225.001]
  • [Cites] Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):409-16 [15734966.001]
  • [Cites] Radiology. 2005 Aug;236(2):519-26 [16040909.001]
  • [Cites] Am J Gastroenterol. 2005 Dec;100(12):2771-6 [16393234.001]
  • [Cites] AJR Am J Roentgenol. 2006 Mar;186(3):718-28 [16498099.001]
  • [Cites] Clin Gastroenterol Hepatol. 2006 Mar;4(3):343-8 [16527698.001]
  • [Cites] Radiology. 2006 May;239(2):457-63 [16543590.001]
  • [Cites] Radiology. 2006 May;239(2):464-71 [16569789.001]
  • [Cites] Radiology. 2006 May;239(2):313-6 [16641348.001]
  • [Cites] Cancer. 2007 Jun 1;109(11):2213-21 [17455218.001]
  • [Cites] N Engl J Med. 2007 Oct 4;357(14):1403-12 [17914041.001]
  • [Cites] AJR Am J Roentgenol. 2008 Jan;190(1):136-44 [18094303.001]
  • [Cites] Gastroenterology. 2008 May;134(5):1570-95 [18384785.001]
  • [Cites] Radiology. 2008 Oct;249(1):151-9 [18796673.001]
  • [Cites] N Engl J Med. 2008 Sep 18;359(12):1207-17 [18799557.001]
  • [Cites] Gastroenterology. 2008 Oct;135(4):1100-5 [18691580.001]
  • [Cites] Ann Intern Med. 2008 Nov 4;149(9):627-37 [18838716.001]
  • [Cites] Gut. 2009 Feb;58(2):241-8 [18852257.001]
  • [Cites] Radiology. 2000 May;215(2):353-7 [10796907.001]
  • [Cites] Gastroenterology. 2009 Mar;136(3):1121-2; author reply 122-3 [19167389.001]
  • [Cites] Am J Gastroenterol. 2009 Mar;104(3):739-50 [19240699.001]
  • [Cites] Am J Prev Med. 2009 Jul;37(1):8-16 [19442479.001]
  • [Cites] JAMA. 2009 Jun 17;301(23):2453-61 [19531785.001]
  • [Cites] Radiology. 2002 Jul;224(1):25-33 [12091658.001]
  • (PMID = 19965295.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Comparative Study; Lectures
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2797457
  •  go-up   go-down


9. Ghelase F, Mogoş DS, Mărgăritescu D, Iordache S, Ghelase MS, Râmboiu S, Mogoş G, Bică M, Săftoiu A, Georgescu I: [Correlation of adenomatous polyps and early colorectal cancer. Diagnostic and therapeutic implications]. Chirurgia (Bucur); 2009 Mar-Apr;104(2):159-65
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Correlation of adenomatous polyps and early colorectal cancer. Diagnostic and therapeutic implications].
  • AIM: To detect the patients with colorectal adenomatous polyps or those with adenocarcinoma areas with a view to prevent and to treat the malignant disease.
  • MATERIAL AND METHOD: A prospective study including 309 patients hospitalized between 2000-2005 diagnosed with isolated adenomatous polyps after repeated colonoscopies.
  • The research method was selective screening with identification of risk factors regarding the evolution of colorectal polyps in early cancer, using colonoscopy and histopathological examination.
  • RESULTS: We identified 464 single or multiple isolated polyps of which 399 were adenomas, 59 hyperplastic polyps and 6 other types of lesions.
  • Histologically we recorded 41 (13.27%) polyps with a low grade of dysplasia, 56 (18.12%) with severe dysplasia and 30 (9.7%) intramucosal adenocarcinoma with submucosal invasion.
  • TREATMENT: Colonoscopic polypectomy was used for benign polyps and in situ carcinoma.
  • In case of adenocarcinoma is probable the invasion of submucosal lymphatics being shown a colorectal resection as appropriate.
  • CONCLUSIONS: High grade of dysplasia, the number of polyps, ulceration, bleeding, intraepithelial areas of neoplastic transformation are predictive factors for early colorectal cancer.
  • Depth of submucosal invasion of malignant transformed polyps are important pathological factors to predict lymphatic metastasis and to select the therapeutic procedure.
  • [MeSH-major] Adenomatous Polyps / diagnosis. Adenomatous Polyps / surgery. Colectomy / methods. Colonoscopy. Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Carcinoma in Situ / diagnosis. Carcinoma in Situ / surgery. Cell Transformation, Neoplastic / pathology. Colonic Polyps / diagnosis. Colonic Polyps / surgery. Female. Humans. Male. Prospective Studies. Risk Factors. Treatment Outcome

  • Genetic Alliance. consumer health - Colorectal Cancer.
  • MedlinePlus Health Information. consumer health - Colonoscopy.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19499658.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
  •  go-up   go-down


10. Abbass R, Rigaux J, Al-Kawas FH: Nonampullary duodenal polyps: characteristics and endoscopic management. Gastrointest Endosc; 2010 Apr;71(4):754-9
MedlinePlus Health Information. consumer health - Intestinal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nonampullary duodenal polyps: characteristics and endoscopic management.
  • BACKGROUND: Guidelines for endoscopic resection and surveillance of nonampullary duodenal (NAD) polyps are still not well-defined.
  • OBJECTIVE: To describe the characteristics of NAD polyps and evaluate the role of endoscopic management.
  • PATIENTS: This study involved 59 patients with NAD polyps.
  • The mean (+/- standard deviation) polyp size was 17.2 mm +/- 1.6 mm.
  • Multiple endoscopies were needed in 5% of cases.
  • Polyps of >2 cm were associated with higher rates of adenoma and a higher incidence of recurrence.
  • CONCLUSION: NAD polyps were large, sessile, and more commonly found in the second portion of the duodenum.
  • They are more likely to be adenomatous when the lesion size is >2 cm.
  • [MeSH-major] Duodenal Neoplasms / surgery. Duodenoscopy / methods. Intestinal Polyps / surgery
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adenoma / diagnosis. Adenoma / pathology. Adenoma / surgery. Biopsy. Carcinoid Tumor / diagnosis. Carcinoid Tumor / pathology. Carcinoid Tumor / surgery. Duodenum / pathology. Duodenum / surgery. Equipment Design. Follow-Up Studies. Humans. Hyperplasia. Intestinal Mucosa / pathology. Intestinal Mucosa / surgery. Laser Therapy. Lasers, Gas. Lipoma / diagnosis. Lipoma / pathology. Lipoma / surgery. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / surgery. Retrospective Studies

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20363416.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


11. Li D, Jin C, McCulloch C, Kakar S, Berger BM, Imperiale TF, Terdiman JP: Association of large serrated polyps with synchronous advanced colorectal neoplasia. Am J Gastroenterol; 2009 Mar;104(3):695-702
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association of large serrated polyps with synchronous advanced colorectal neoplasia.
  • OBJECTIVES: Serrated polyps of the colorectum are a histologically and genetically heterogeneous group of lesions, which include classic hyperplasic polyps, sessile serrated adenomas (SSAs), and traditional serrated adenomas.
  • This study sought to determine the association between the presence of large serrated colorectal polyps and synchronous advanced colorectal neoplasia.
  • METHODS: Among 4,714 asymptomatic subjects who underwent screening colonoscopy, cases of advanced colorectal neoplasia (tubular adenoma > or =1 cm, adenoma with any villous histology, adenoma with carcinoma in situ / high-grade dysplasia, or invasive adenocarcinoma) were compared with controls without advanced neoplasia with respect to candidate predictors, including age, sex, family history of colorectal cancer, body mass index, the presence and number of small tubular adenomas (<1 cm), the presence of multiple small serrated polyps (<1 cm), and the presence of large serrated polyps (> or =1 cm).
  • RESULTS: Among 467 cases and 4,247 controls, independent predictors of advanced colorectal neoplasia were increasing age (odds ratio (OR)=4.51; 95% confidence interval (CI), 1.43-14.3; P=0.01 for subjects > or =80 years vs. 50-54 years of age); non-advanced tubular adenomas (OR=2.33; 95% CI 1.37-3.96, P=0.0017 for 3 or more); and large serrated polyps (OR=3.24; 95% CI 2.05-5.13, P<0.0001).
  • In total, 109 subjects (2.3% of the study population) had large serrated polyps.
  • Right- and left-sided large serrated polyps had a similar association with advanced colorectal neoplasia (OR=3.38 vs. 2.66, P=0.62).
  • CONCLUSIONS: Large serrated polyps are strongly and independently associated with synchronous advanced colorectal neoplasia.
  • Our results suggest that large serrated polyps may be a marker for advanced colorectal neoplasia.
  • Further studies are needed to determine whether the association with advanced neoplasia differs among subsets of serrated polyps, particularly SSAs and classic hyperplastic polyps.
  • [MeSH-major] Colonic Polyps / complications. Colorectal Neoplasms / pathology. Neoplasms, Multiple Primary / pathology
  • [MeSH-minor] Adenomatous Polyps / complications. Adenomatous Polyps / pathology. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged

  • MedlinePlus Health Information. consumer health - Colonic Polyps.
  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19223889.001).
  • [ISSN] 1572-0241
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


12. Donnellan KA, Bigler SA, Wein RO: Papillary thyroid carcinoma and familial adenomatous polyposis of the colon. Am J Otolaryngol; 2009 Jan-Feb;30(1):58-60
MedlinePlus Health Information. consumer health - Thyroid Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Papillary thyroid carcinoma and familial adenomatous polyposis of the colon.
  • OBJECTIVE: Case report and limited review of the literature on the topic of papillary thyroid carcinoma and familial adenomatous polyposis and its genetic associations.
  • METHODS: A patient with multiple prior surgeries for colonic polyps, abdominal perineal resection for colorectal cancer, and wedge resection for metastatic adenocarcinoma (consistent with rectal primary) presented with a thyroid mass.
  • Pathologic examination revealed the cribriform-morular variant of papillary carcinoma that has been reported in patients with familial adenomatous polyposis.
  • CONCLUSIONS: Cribriform-morular variant of papillary thyroid carcinoma is an uncommon diagnosis known to be associated with familial adenomatous polyposis.
  • [MeSH-major] Adenomatous Polyposis Coli / diagnosis. Carcinoma, Papillary / pathology. Thyroid Neoplasms / diagnosis. Thyroidectomy / methods

  • Genetic Alliance. consumer health - Familial Adenomatous Polyposis (FAP).
  • Genetic Alliance. consumer health - Familial Polyposis.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19027515.001).
  • [ISSN] 1532-818X
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 17
  •  go-up   go-down


13. Stănciulea O, Preda C, Herlea V, Popa M, Ulmeanu D, Vasilescu C: [Rare indication of cephalic duodenopancreatectomy with total gastrectomy--periampullary carcinoma in moderate form of familial adenomatous polyposis]. Chirurgia (Bucur); 2007 Mar-Apr;102(2):215-20
MedlinePlus Health Information. consumer health - Intestinal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Rare indication of cephalic duodenopancreatectomy with total gastrectomy--periampullary carcinoma in moderate form of familial adenomatous polyposis].
  • We present the case of a 52 years old man, with significant familial history, diagnosed with familial adenomatous polyposis-attenuated form, with no clinical and endoscopic surveillance until 2001 when he was admitted for an upper gastrointestinal haemorrhage episode.
  • Upper gastrointestinal scopy revealed duodenal adenomatous polyps and gastric hyperplastic polyps.
  • The histopathological exam revealed duodenal G2 adenocarcinoma pT3N0, and gastric hyperplastic polyps with no signs of dysplasia.
  • In 2002 the patient was admitted for rectal bleeding and colonoscopy showed 2 sigmoid polyps, appropriate for endoscopic removal and a poly-lobate polyp in the transverse colon.
  • The patient underwent transverse colectomy (the histopathological exam--in situ carcinoma).
  • March 2003--the patient underwent endoscopic removal for a rectal polyp (histopathological exam: moderate dysplasia).
  • In 2005 was noted a pulmonary nodule, located in the postero-apical segment of upper left lobe, for which left superior lobe resection was performed (the histopathological exam: metastatic adenocarcinoma).
  • Intraoperatively were noted: peritoneal carcinomatosis and multiple liver metastasis.
  • The surgical procedure recommended in patients with attenuated form of familial adenomatous polyposis and suspect periampullary lesions is duodenopancreatectomy.
  • The particularity of the case is the association of total gastrectomy for gastric hyperplastic polyps.
  • [MeSH-major] Adenomatous Polyposis Coli / surgery. Carcinoma / surgery. Duodenal Neoplasms / surgery. Gastrectomy. Neoplasms, Multiple Primary / surgery. Pancreaticoduodenectomy / methods

  • Genetic Alliance. consumer health - Familial Adenomatous Polyposis (FAP).
  • Genetic Alliance. consumer health - Familial Polyposis.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17615925.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
  •  go-up   go-down


14. Jerkic S, Rosewich H, Scharf JG, Perske C, Füzesi L, Wilichowski E, Gärtner J: Colorectal cancer in two pre-teenage siblings with familial adenomatous polyposis. Eur J Pediatr; 2005 May;164(5):306-10
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Colorectal cancer in two pre-teenage siblings with familial adenomatous polyposis.
  • Familial adenomatous polyposis (FAP) is an autosomal dominant disorder that characteristically presents with colon cancer in early adult life.
  • Colonoscopy showed that the colon was carpeted with a myriad of polyps.
  • Oesophago-gastric and duodenal endoscopy revealed that polyps had also developed in the duodenum.
  • Multiple biopsies indicated neoplastic lesions.
  • The diagnosis of an adenocarcinoma of the colon and further adenomatous polyps with low-grade and high-grade dysplasia was confirmed by histology.
  • CONCLUSION: Children with familial adenomatous polyposis are at risk for colon cancer and emphasise the need for early tumour recognition.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenomatous Polyposis Coli / diagnosis. Carcinoma / diagnosis. Colorectal Neoplasms / diagnosis. Siblings


15. Nzegwu MA, Osuagwu CC, Machembarrena JM, Ezeofor S, Picardo NG, Emegakor C, Odiakosa T: Familial adenomatous polyposis complicated with an invasive colo-rectal adenocarcinoma in a 26-year-old Nigerian male - a rare finding. Eur J Cancer Care (Engl); 2007 Mar;16(2):198-200
Genetic Alliance. consumer health - Familial Polyposis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Familial adenomatous polyposis complicated with an invasive colo-rectal adenocarcinoma in a 26-year-old Nigerian male - a rare finding.
  • Familial adenomatous polyposis is very rare in our environment.
  • He had also previously had a previous proctoscopy and rectal biopsy that showed numerous adenomatous polyps with dysplastic changes confirmed by histology.
  • Barium enema revealed multiple polyps up to the right side of the transverse colon.
  • Repeat histology after panproctocolectomy confirmed foci of invasive adenocarcinoma of the colon up to the muscle coat.
  • [MeSH-major] Adenocarcinoma / pathology. Adenomatous Polyposis Coli / pathology. Colonic Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

  • Genetic Alliance. consumer health - Familial Adenomatous Polyposis (FAP).
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17371432.001).
  • [ISSN] 0961-5423
  • [Journal-full-title] European journal of cancer care
  • [ISO-abbreviation] Eur J Cancer Care (Engl)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  •  go-up   go-down


16. Parés D, García-Ruiz A, Biondo S, Blanco I, Llort G, Arriol E, de Oca J, del Río C, Osorio A, Navarro M, Martí-Ragué J, Jaurrieta E: [Current status of follow-up of the upper digestive tract in familial adenomatous polyposis]. Gastroenterol Hepatol; 2006 Jan;29(1):15-20
MedlinePlus Health Information. consumer health - Stomach Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Current status of follow-up of the upper digestive tract in familial adenomatous polyposis].
  • [Transliterated title] Estado actual del seguimiento del área gastroduodenal en la poliposis adenomatosa familiar.
  • Familiar adenomatous polyposis (FAP) is a hereditary disease characterized by the development of multiple adenomatous polyps in the gastrointestinal tract and colorectal cancer in practically all patients who do not receive appropriate treatment.
  • Because of the possibility of malignant transformation of these polyps, adequate monitoring is required, even though the optimal follow-up schedule has not yet been defined.
  • In the present article, we report a case of a gastric adenocarcinoma detected during the follow-up of a patient diagnosed with FAP, as well as a review of the literature on this subject.
  • Subsequently, a follow-up schedule should be designed, according to the number and histological characteristics of the polyps observed.
  • [MeSH-major] Adenocarcinoma / etiology. Adenomatous Polyposis Coli / complications. Stomach Neoplasms / etiology

  • Genetic Alliance. consumer health - Familial Adenomatous Polyposis (FAP).
  • Genetic Alliance. consumer health - Familial Polyposis.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16393625.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 34
  •  go-up   go-down


17. Tatsu K, Hayashi S, Shimada I, Matsui K: Cyclooxygenase-2 in sporadic colorectal polyps: immunohistochemical study and its importance in the early stages of colorectal tumorigenesis. Pathol Res Pract; 2005;201(6):427-33
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cyclooxygenase-2 in sporadic colorectal polyps: immunohistochemical study and its importance in the early stages of colorectal tumorigenesis.
  • To evaluate the role of COX-2 in early stages of colorectal tumorigenesis, we immunohistochemically investigated the frequency and localization of COX-2 in sporadic colorectal polyps that showed various histology using a commercially available monoclonal antibody.
  • A total of 105 colorectal polyps were examined.
  • COX-2 was expressed in neoplastic epithelial cells and interstitial macrophages that were distributed mainly in the superficial areas of polyps.
  • Within CIAs, significantly higher COX-2 LIs were obtained in the adenomatous components than in the carcinomatous components (p < 0.05).
  • The size of polyps was not correlated with COX-2 expression irrespective of their histology.
  • [MeSH-major] Adenocarcinoma / enzymology. Adenoma / enzymology. Colonic Polyps / enzymology. Colorectal Neoplasms / enzymology. Neoplasms, Multiple Primary / enzymology. Prostaglandin-Endoperoxide Synthases / metabolism

  • MedlinePlus Health Information. consumer health - Colonic Polyps.
  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16136748.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Membrane Proteins; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases
  •  go-up   go-down


18. Gibson CJ, Parry NM, Jakowski RM, Cooper J: Adenomatous polyp with intestinal metaplasia of the esophagus (Barrett esophagus) in a dog. Vet Pathol; 2010 Jan;47(1):116-9
MedlinePlus Health Information. consumer health - Esophageal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenomatous polyp with intestinal metaplasia of the esophagus (Barrett esophagus) in a dog.
  • Multiple endoscopic biopsy specimens of esophageal mucosa were received from a 13-year-old castrated male standard Poodle.
  • This article reports a case of spontaneous esophageal adenomatous polyp with intestinal metaplasia (Barrett esophagus) and reviews the pathogenesis of esophageal metaplasia and adenocarcinoma.
  • [MeSH-major] Adenomatous Polyps / veterinary. Barrett Esophagus / veterinary. Dog Diseases / pathology. Esophageal Neoplasms / veterinary. Intestines / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20080491.001).
  • [ISSN] 1544-2217
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


19. de Oliveira Ribas M, Martins WD, de Sousa MH, de Aguiar Koubik AC, Avila LF, Zanferrari FL, Martins G: Oral and maxillofacial manifestations of familial adenomatous polyposis (Gardner's syndrome): a report of two cases. J Contemp Dent Pract; 2009;10(1):82-90
Genetic Alliance. consumer health - Familial Polyposis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oral and maxillofacial manifestations of familial adenomatous polyposis (Gardner's syndrome): a report of two cases.
  • BACKGROUND: Gardner's syndrome is an autosomal dominant disease characterized by gastrointestinal polyps that develop in the colon as well as in the stomach and upper intestine, along with multiple osteomas, skin, and soft tissue tumors.
  • Early diagnosis and therapy of the disease are critical because polyps have a 100% risk of undergoing malignant transformation.
  • Further investigation revealed a familial adenomatous polyposis (FAP) complicated by adenocarcinoma of the colon.
  • Radiographic examination revealed multiple radiopacities in the maxilla, mandible left temporomandibular joint, and in the left mandibular angle.
  • Multiple impacted teeth were present.

  • Genetic Alliance. consumer health - Familial Adenomatous Polyposis (FAP).
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19142260.001).
  • [ISSN] 1526-3711
  • [Journal-full-title] The journal of contemporary dental practice
  • [ISO-abbreviation] J Contemp Dent Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


20. Will O, Carvajal-Carmona LG, Gorman P, Howarth KM, Jones AM, Polanco-Echeverry GM, Chinaleong JA, Günther T, Silver A, Clark SK, Tomlinson I: Homozygous PMS2 deletion causes a severe colorectal cancer and multiple adenoma phenotype without extraintestinal cancer. Gastroenterology; 2007 Feb;132(2):527-30
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Homozygous PMS2 deletion causes a severe colorectal cancer and multiple adenoma phenotype without extraintestinal cancer.
  • BACKGROUND & AIMS: We report a patient of Indian descent with parental consanguinity, who developed 10 carcinomas and 35 adenomatous polyps at age 23 and duodenal adenocarcinoma at age 25.
  • PMS2 mutations-and perhaps other homozygous mismatch repair mutations-should be considered in any patient presenting with multiple gastrointestinal tumors, since our patient could not be distinguished clinically from cases with attenuated familial adenomatous polyposis or MUTYH-associated polyposis.
  • [MeSH-major] Adenomatous Polyps / genetics. Adenosine Triphosphatases / genetics. Colorectal Neoplasms / genetics. DNA Repair Enzymes / genetics. DNA-Binding Proteins / genetics. Gene Deletion. Homozygote. Intestinal Polyposis / genetics
  • [MeSH-minor] Adenomatous Polyposis Coli / diagnosis. Adult. DNA Glycosylases / genetics. Diagnosis, Differential. Duodenal Neoplasms / genetics. Fatal Outcome. Gene Expression Regulation, Neoplastic. Humans. Male. Microsatellite Instability. Mutation. Pedigree. Protein-Serine-Threonine Kinases. Proto-Oncogene Proteins / genetics. Receptors, Transforming Growth Factor beta / genetics. Severity of Illness Index. ras Proteins

  • Genetic Alliance. consumer health - Colorectal Cancer.
  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • COS Scholar Universe. author profiles.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17258725.001).
  • [ISSN] 0016-5085
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / KRAS protein, human; 0 / Proto-Oncogene Proteins; 0 / Receptors, Transforming Growth Factor beta; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.30 / transforming growth factor-beta type II receptor; EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase; EC 3.6.1.- / Adenosine Triphosphatases; EC 3.6.1.- / PMS2 protein, human; EC 3.6.5.2 / ras Proteins; EC 6.5.1.- / DNA Repair Enzymes
  •  go-up   go-down


21. Colakoglu T, Yildirim S, Kayaselcuk F, Nursal TZ, Ezer A, Noyan T, Karakayali H, Haberal M: Clinicopathological significance of PTEN loss and the phosphoinositide 3-kinase/Akt pathway in sporadic colorectal neoplasms: is PTEN loss predictor of local recurrence? Am J Surg; 2008 Jun;195(6):719-25
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Deficient PTEN expression leads to activation of the phosphoinositide 3-kinase (PI3K)/Akt (pAkt) signaling pathway, which may contribute to multiple human cancers.
  • The relation between PTEN expression and Akt activation is still unclear in colorectal cancers and adenomatous polyps.
  • METHODS: PTEN and pAkt expression were evaluated in 76 primary colorectal cancers and 25 adenomatous colorectal polyp tissues using immunohistochemical staining on paraffin-embedded sections.
  • RESULTS: In colorectal cancers, pAkt expression was found to be significantly higher than polyps (P = .007).
  • On the other hand, PTEN expression was significantly lower in polyps (P <.0001).
  • A negative correlation between PTEN and pAkt expression was found in colon cancer patients (P = .010), whereas no significiant association was found in adenomatous polyps (P = .403).
  • [MeSH-major] Adenocarcinoma / metabolism. Colorectal Neoplasms / metabolism. Neoplasm Recurrence, Local. PTEN Phosphohydrolase / metabolism. Phosphatidylinositol 3-Kinases / metabolism. Proto-Oncogene Proteins c-akt / metabolism. Signal Transduction
  • [MeSH-minor] Adenomatous Polyps / genetics. Adenomatous Polyps / metabolism. Adult. Aged. Aged, 80 and over. Female. Gene Expression. Genes, Tumor Suppressor. Humans. Immunohistochemistry. Male. Middle Aged

  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18440486.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
  •  go-up   go-down


22. Bosserhoff AK, Grussendorf-Conen EI, Rübben A, Rudnik-Schöneborn S, Zerres K, Buettner R, Merkelbach-Bruse S: Multiple colon carcinomas in a patient with Cowden syndrome. Int J Mol Med; 2006 Oct;18(4):643-7
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple colon carcinomas in a patient with Cowden syndrome.
  • Cowden syndrome is a non-adenomatous gastrointestinal polyposis syndrome with inactivation of PTEN, a dual-phosphatase tumor suppressor gene.
  • However, the risk of malignant transformation in gastrointestinal polyps is still unclear.
  • The index patient was a 56 year-old woman having multiple facial papules, acral keratosis, oral papillomatosis, multiple benign breast and thyroid tumors and gastrointestinal polyposis.
  • Progression to invasive adenocarcinoma occured in two pre-existing hamartomatous polyps.
  • [MeSH-major] Colonic Neoplasms / pathology. Hamartoma Syndrome, Multiple / pathology

  • Genetic Alliance. consumer health - Cowden Syndrome.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16964417.001).
  • [ISSN] 1107-3756
  • [Journal-full-title] International journal of molecular medicine
  • [ISO-abbreviation] Int. J. Mol. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Codon, Nonsense; 0 / RNA, Messenger; EC 3.1.3.67 / PTEN Phosphohydrolase
  •  go-up   go-down


23. Van Kerkhóve F, Coenegrachts K, Steyaert L, Van Den Berghe I, Casselman JW: Collision tumor in the ileum: a rare combination of an adenocarcinoma and small cell neuroendocrine tumor. JBR-BTR; 2006 Sep-Oct;89(5):258-60
MedlinePlus Health Information. consumer health - Ultrasound.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Collision tumor in the ileum: a rare combination of an adenocarcinoma and small cell neuroendocrine tumor.
  • Pathology revealed a rare ileal collision tumor consisting of an adenocarcinoma and a small cell neuroendocrine tumor with peritoneal metastasis of neuroendocrine origin and coincidental benign lesions on both ovaries.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma, Villous / diagnosis. Adenomatous Polyps / diagnosis. Carcinoma, Small Cell / diagnosis. Ileal Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Tomography, X-Ray Computed. Ultrasonography

  • Genetic Alliance. consumer health - Pancreatic islet cell tumors.
  • MedlinePlus Health Information. consumer health - CT Scans.
  • MedlinePlus Health Information. consumer health - Intestinal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17147014.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
  •  go-up   go-down


24. Barreda Costa C, Vila Gutierrez S, Salazar Cabrera F, Barriga Calle E, Velarde Criado H, Barriga Briceño J: [Advanced adenoma in 3700 colonoscopies]. Rev Gastroenterol Peru; 2010 Apr-Jun;30(2):113-20
MedlinePlus Health Information. consumer health - Colonoscopy.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Adenomas avanzados en 3,700 colonoscopías.
  • OBJECTIVES: To determine the prevalence of colon polyps, distribution in the colon, as well as their histological characteristics, with special mention on advanced adenomas, in an adult population at an endoscopy center in Lima.
  • Each polyp was studied separately and its histological findings recorded.
  • RESULTS: 3,701 colonoscopies were done in 3,690 patients; 1,492 (40,4%) had polyps and were included in the study.
  • 997 (27%) had adenomatous polyps and 495 (13.4%) non adenomatous polyps.
  • Adenomatous polyps were found throughout the colon, with a predominance of hyperplasic polyps in the rectum.
  • 78% of the adenomatous polyps and 84% of the advanced adenomas were found in patients older than 50 years old.
  • In this group of patients, significant risk factors were: prior history of adenomas or colorectal cancer (46/203 vs. 63/495; p<0.01), and multiple adenomatous polyps found during colonoscopy (67/203 vs. 121/794; p<0.01).
  • CONCLUSIONS: Adenomatous polyps were the most frequently found polyps in our study; approximately 20% were advanced lesions, especially in patients older than 50 years old.
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenoma / epidemiology. Colonic Neoplasms / epidemiology. Colonic Polyps / epidemiology. Colonoscopy / statistics & numerical data. Rectal Neoplasms / epidemiology
  • [MeSH-minor] Adenomatous Polyps / diagnosis. Adenomatous Polyps / epidemiology. Adenomatous Polyps / pathology. Adult. Age Factors. Aged. Aged, 80 and over. Early Diagnosis. Humans. Hyperplasia. Middle Aged. Motivation. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / epidemiology. Neoplasms, Multiple Primary / pathology. Organ Specificity. Peru / epidemiology. Prospective Studies. Young Adult

  • MedlinePlus Health Information. consumer health - Colonic Polyps.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20644602.001).
  • [ISSN] 1609-722X
  • [Journal-full-title] Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
  • [ISO-abbreviation] Rev Gastroenterol Peru
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Peru
  •  go-up   go-down


25. Durno CA, Holter S, Sherman PM, Gallinger S: The gastrointestinal phenotype of germline biallelic mismatch repair gene mutations. Am J Gastroenterol; 2010 Nov;105(11):2449-56
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • More than one-third of patients had multiple colorectal adenomas (>10 polyps).
  • Six individuals with biallelic MMR gene mutations have been reported with small bowel adenocarcinoma (mean age 20 years (range: 11-41)).
  • This distinct phenotype includes multiple adenomatous polyps and CAL skin lesions.

  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20531397.001).
  • [ISSN] 1572-0241
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


26. Gatalica Z, Torlakovic E: Pathology of the hereditary colorectal carcinoma. Fam Cancer; 2008;7(1):15-26

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pathologic examination of the biopsy or resection specimen can help in identification of unsuspected cases of certain forms of hereditary CRC due to the characteristic morphologic findings.
  • The presence of intra-epithelial lymphocytes is single most helpful morphologic feature in identification of CRC caused by deficiency in MMR proteins, for which MSI-H status is a good marker but morphologic features and MSI-H do not differentiate tumors caused by germline mutations in one of the MMR genes (Lynch syndrome) from sporadic CRC due to inactivation of MLH-1 through promoter methylation.
  • Hereditary CRC may also arise in various familial polyposis syndromes which include familial adenomatous polyposis (FAP), attenuated FAP and other multiple adenomas syndromes as well as various hamartomatous polyposis syndromes.
  • All of these rare conditions have characteristic clinical presentation and histopathologic features of polyps and most of them have defined genetic abnormality.
  • [MeSH-major] Adenomatous Polyposis Coli / pathology. Colorectal Neoplasms, Hereditary Nonpolyposis / pathology. Lymphocytes, Tumor-Infiltrating / pathology. Peutz-Jeghers Syndrome / pathology
  • [MeSH-minor] Adenocarcinoma, Mucinous / pathology. Biomarkers, Tumor. Carcinoma, Medullary / pathology. DNA Mismatch Repair. Diagnosis, Differential. Genetic Predisposition to Disease. Genomic Instability. Germ-Line Mutation. Humans

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17564815.001).
  • [ISSN] 1389-9600
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 96
  •  go-up   go-down


27. Gimeno-García AZ, Ramírez F, Gonzalo V, Balaguer F, Petit A, Pellisé M, Llach J, Bordas JM, Piqué JM, Castells A: [High-grade dysplasia as a risk factor of metachronous advanced colorectal neoplasms in patients with advanced adenomas]. Gastroenterol Hepatol; 2007 Apr;30(4):207-11
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Displasia de alto grado como factor de riesgo de neoplasia colorrectal avanzada metacrónica, en pacientes con adenomas avanzados.
  • Patients with a history of colorectal cancer (CRC), inflammatory bowel disease, familial adenomatous polyposis or patients who met the Amsterdam criteria, and those without colonoscopic monitoring were excluded.
  • The number of metachronic polyps (p = 0.67), adenomas (p = 0.73), AA (p = 0.93) and AA with HGD (p = 0.88) was also similar.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Colonic Polyps / pathology. Colonoscopy / methods. Colorectal Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Precancerous Conditions / pathology

  • MedlinePlus Health Information. consumer health - Colonic Polyps.
  • MedlinePlus Health Information. consumer health - Colonoscopy.
  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17408548.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
  •  go-up   go-down


28. Jasperson KW, Blazer KR, Lowstuter K, Weitzel JN: Working through a diagnostic challenge: colonic polyposis, Amsterdam criteria, and a mismatch repair mutation. Fam Cancer; 2008;7(4):281-5
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The two most common causes of hereditary colorectal cancer are Lynch syndrome and familial adenomatous polyposis (FAP).
  • Here we describe a proband who presented with greater than 50 adenomatous colonic polyps prior to developing cancer of the colon and urinary bladder, and a family history that fulfills the Amsterdam criteria.
  • We outline evidence supporting the pathogenicity of the identified hMSH6 mutation (arg772trp) and suggest possible etiologies for the unexplained colonic adenomatous polyposis.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18176851.001).
  • [ISSN] 1389-9600
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / M01 RR000043; United States / NCI NIH HHS / CA / R25 CA085771; United States / NCRR NIH HHS / RR / M01 RR00043; United States / NCI NIH HHS / CA / R25 CA85771
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein
  •  go-up   go-down


29. de Ferro SM, Suspiro A, Fidalgo P, Lage P, Rodrigues P, Fragoso S, Vitoriano I, Baltazar C, Albuquerque C, Bettencourt A, Leitão CN: Aggressive phenotype of MYH-associated polyposis with jejunal cancer and intra-abdominal desmoid tumor: report of a case. Dis Colon Rectum; 2009 Apr;52(4):742-5
MedlinePlus Health Information. consumer health - Intestinal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MYH-associated polyposis is an inherited autosomal recessive disease, linked to biallelic germline MYH mutations, which predisposes to the development of multiple colorectal adenomas and cancer.
  • He presented at aged 30 years with more than 100 colonic polyps and 4 colonic adenocarcinomas.
  • Similar to patients with familial adenomatous polyposis, desmoid tumors also may be part of the clinical spectrum of MYH-associated polyposis and may prove to be a significant clinical problem in patients submitted to prophylactic colectomy.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Colorectal Neoplasms / genetics. Fibromatosis, Aggressive / genetics. Jejunal Neoplasms / genetics. Neoplasms, Multiple Primary / genetics. Peritoneal Neoplasms / genetics
  • [MeSH-minor] Adenocarcinoma / genetics. Adenoma / genetics. Adult. DNA Glycosylases / genetics. Duodenal Neoplasms / genetics. Genetic Predisposition to Disease. Germ-Line Mutation. Humans. Intestinal Neoplasms / genetics. Intestinal Obstruction / etiology. Liver Neoplasms / secondary. Male. Mesentery. Mutation. Phenotype. Syndrome

  • Genetic Alliance. consumer health - Desmoid Tumor.
  • Genetic Alliance. consumer health - MYH-associated polyposis.
  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19404084.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.2.2.- / DNA Glycosylases
  •  go-up   go-down


30. Rio Frio T, Lavoie J, Hamel N, Geyer FC, Kushner YB, Novak DJ, Wark L, Capelli C, Reis-Filho JS, Mai S, Pastinen T, Tischkowitz MD, Marcus VA, Foulkes WD: Homozygous BUB1B mutation and susceptibility to gastrointestinal neoplasia. N Engl J Med; 2010 Dec 30;363(27):2628-37
SciCrunch. Clinical Genomic Database: Data: Gene Annotation .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A patient received a diagnosis of adenocarcinoma of the ampulla of Vater at 34 years of age.
  • Two decades later, adenomatous polyps were found, followed by multiple primary invasive adenocarcinomas of both the colon and the stomach.
  • Our findings expand the phenotype associated with BUB1B mutations and the mosaic variegated aneuploidy syndrome to include common adult-onset cancers and provide evidence for the interdependency of the APC protein (encoded by the adenomatous polyposis coli gene) and the BUBR1 protein (encoded by BUB1B) in humans. (Funded by the Turner Family Cancer Research Fund and others.).
  • [MeSH-minor] Adenocarcinoma / genetics. Adenoma / genetics. Adenomatous Polyposis Coli Protein / genetics. Adenomatous Polyposis Coli Protein / metabolism. Aged. Chromosome Disorders / genetics. DNA Mutational Analysis. Female. Genomic Instability. Homozygote. Humans. Karyotyping. Male. Mosaicism. Oligonucleotide Array Sequence Analysis. Pedigree. Phenotype. Spindle Apparatus

  • Faculty of 1000. commentaries/discussion - See the articles recommended by F1000Prime's Faculty of more than 8,000 leading experts in Biology and Medicine. (subscription/membership/fee required).
  • SciCrunch. OMIM: Data: Gene Annotation .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] N Engl J Med. 2010 Dec 30;363(27):2665-6 [21190461.001]
  • [CommentIn] N Engl J Med. 2011 Mar 31;364(13):1279-80 [21449797.001]
  • (PMID = 21190457.001).
  • [ISSN] 1533-4406
  • [Journal-full-title] The New England journal of medicine
  • [ISO-abbreviation] N. Engl. J. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; EC 2.7.11.1 / BUB1 protein, human; EC 2.7.11.1 / Bub1 spindle checkpoint protein; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; Mosaic variegated aneuploidy syndrome
  •  go-up   go-down


31. Kim KM, Lee EJ, Kim YH, Chang DK, Odze RD: KRAS mutations in traditional serrated adenomas from Korea herald an aggressive phenotype. Am J Surg Pathol; 2010 May;34(5):667-75
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In North America, TSAs are relatively uncommon, occur mainly in the left colon, and in some studies, have not been shown to have a strong association with hyperplastic polyp (HPP) or sessile polyp adenoma (SSA) precursor lesions.
  • One hundred and twelve TSAs were evaluated pathologically and categorized according to the grade of dysplasia (either low or high grade) and the presence or absence of adenocarcinoma.
  • TSAs were also separated into those with serrated versus conventional adenomatous dysplasia.
  • As controls 35 conventional adenomas were evaluated, 14 of which had adenocarcinoma.
  • TSAs with high-grade dysplasia and intramucosal adenocarcinoma showed a significantly higher frequency of KRAS mutation and MGMT methylation, and a significantly lower frequency of BRAF mutations, compared with TSAs with low-grade dysplasia (P<0.05).
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cohort Studies. Colonic Polyps / genetics. Colonic Polyps / pathology. DNA Methylation. DNA Modification Methylases / genetics. DNA Modification Methylases / metabolism. DNA Mutational Analysis. DNA Repair Enzymes / genetics. DNA Repair Enzymes / metabolism. DNA, Neoplasm / analysis. Female. Gene Silencing. Humans. Korea. Male. Middle Aged. Neoplasms, Multiple Primary. Phenotype. Prognosis. Proto-Oncogene Proteins B-raf / genetics. Tumor Suppressor Proteins / genetics. Tumor Suppressor Proteins / metabolism

  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20305537.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / KRAS protein, human; 0 / Proto-Oncogene Proteins; 0 / Tumor Suppressor Proteins; EC 2.1.1.- / DNA Modification Methylases; EC 2.1.1.63 / MGMT protein, human; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / ras Proteins; EC 6.5.1.- / DNA Repair Enzymes
  •  go-up   go-down


32. Tan KL, Wilson S, O'Neill C, Gordon D, Napier S: Something not quite right: Gardner syndrome diagnosed by multiple cutaneous lesions and genetic testing. Surgeon; 2005 Dec;3(6):412-5
Genetic Alliance. consumer health - Gardner Syndrome.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Something not quite right: Gardner syndrome diagnosed by multiple cutaneous lesions and genetic testing.
  • Gardner syndrome is a variant of familial adenomatous polyposis characterized by intestinal adenomatous polyps, which can progress to adenocarcinoma, and a variety of extraintestinal manifestations, including skin cysts, osteomas, soft tissue fibrous tumours and a characteristic ocular lesion.
  • Subsequent resection revealed approximately 70 adenomatous colonic polyps in the colon and rectum but no invasive tumour, highlighting the benefits of genetic testing in treatment planning.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16353862.001).
  • [ISSN] 1479-666X
  • [Journal-full-title] The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
  • [ISO-abbreviation] Surgeon
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  •  go-up   go-down


33. Beach R, Chan AO, Wu TT, White JA, Morris JS, Lunagomez S, Broaddus RR, Issa JP, Hamilton SR, Rashid A: BRAF mutations in aberrant crypt foci and hyperplastic polyposis. Am J Pathol; 2005 Apr;166(4):1069-75
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Patients with hyperplastic polyposis have multiple hyperplastic polyps (HPs) and increased risk of colorectal carcinomas.
  • We evaluated BRAF mutations by DNA sequencing in 53 ACF from patients with sporadic colorectal carcinomas and familial adenomatous polyposis, in 18 sporadic HPs from patients with resected colorectal cancer, and in 70 HPs, 4 serrated adenomas, 3 admixed hyperplastic-adenomatous polyps, 10 tubular adenomas, and 6 carcinomas from 17 patients with multiple/large HPs and/or hyperplastic polyposis.
  • In contrast, BRAF mutation was present in 43% of HPs (P = 0.01 versus sporadic HPs), 75% of serrated adenomas, 33% of admixed hyperplastic-adenomatous polyps, 30% of tubular adenomas, and 33% of carcinomas from patients with multiple/large HPs and/or hyperplastic polyposis.
  • BRAF mutation status in patients with multiple/large HPs and/or hyperplastic polyposis correlated with HPs from the same patient (odds ratio, 5.8; P = 0.0002) but associated with younger age (odds ratio, 0.83; P = 0.006 compared to older age), with a large HP (odds ratio, 22.5; P = 0.01 compared with patients with multiple HPs), with location of HPs in the right colon (odds ratio, 3.0; P = 0.03), and with methylation of the p16 gene and the MINT31 locus [odds ratio, 12.2 (P = 0.0001) and 4.4 (P = 0.02), respectively].
  • Our study shows that BRAF mutation status is heterogeneous among patients with multiple/large HPs and/or hyperplastic polyposis, suggesting differences in pathogenesis of HPs that indicate subsets within this phenotype.
  • [MeSH-minor] Adenocarcinoma / genetics. Adenoma / genetics. Aged. Aged, 80 and over. Base Sequence. Female. Humans. Intestinal Mucosa. Intestinal Polyps / genetics. Male. Middle Aged. Molecular Sequence Data

  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • COS Scholar Universe. author profiles.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Nature. 2002 Jun 27;417(6892):949-54 [12068308.001]
  • [Cites] Histopathology. 1988 Dec;13(6):700-2 [2466756.001]
  • [Cites] Cancer Res. 2002 Nov 15;62(22):6451-5 [12438234.001]
  • [Cites] Am J Surg Pathol. 2003 Jan;27(1):65-81 [12502929.001]
  • [Cites] Cancer Res. 2003 Aug 15;63(16):4878-81 [12941809.001]
  • [Cites] Cancer Res. 2003 Sep 1;63(17):5209-12 [14500346.001]
  • [Cites] Oncogene. 2003 Dec 11;22(57):9192-6 [14668801.001]
  • [Cites] Genes Chromosomes Cancer. 2004 Feb;39(2):138-42 [14695993.001]
  • [Cites] Gut. 2004 Apr;53(4):573-80 [15016754.001]
  • [Cites] Carcinogenesis. 2004 Apr;25(4):527-33 [14688025.001]
  • [Cites] Cell. 2004 Mar 19;116(6):855-67 [15035987.001]
  • [Cites] Gut. 2004 Aug;53(8):1137-44 [15247181.001]
  • [Cites] Am J Surg Pathol. 2004 Nov;28(11):1452-9 [15489648.001]
  • [Cites] S Afr Med J. 1978 Mar 25;53(12):454-7 [675387.001]
  • [Cites] Gastrointest Radiol. 1981;6(4):333-5 [7308714.001]
  • [Cites] Am J Surg Pathol. 1984 Jul;8(7):551-6 [6742315.001]
  • [Cites] Am J Surg Pathol. 1990 Jun;14(6):524-37 [2186644.001]
  • [Cites] Cancer. 1993 Jan 15;71(2):306-14 [8422622.001]
  • [Cites] J Natl Cancer Inst. 1993 Dec 15;85(24):2004-7 [8246286.001]
  • [Cites] Cancer Res. 1993 Dec 15;53(24):5849-52 [8261392.001]
  • [Cites] Cancer Res. 1994 Nov 1;54(21):5523-6 [7923189.001]
  • [Cites] Gastroenterology. 1995 Feb;108(2):434-40 [7835585.001]
  • [Cites] Neth J Med. 1995 Apr;46(4):185-8 [7760968.001]
  • [Cites] Genes Chromosomes Cancer. 1995 Nov;14(3):182-8 [8589034.001]
  • [Cites] Gastroenterology. 1996 Mar;110(3):748-55 [8608884.001]
  • [Cites] Cell. 1996 Oct 18;87(2):159-70 [8861899.001]
  • [Cites] Cancer Res. 1996 Dec 1;56(23):5339-41 [8968080.001]
  • [Cites] Pathology. 1997 Feb;29(1):28-33 [9094174.001]
  • [Cites] Gut. 1997 May;40(5):660-3 [9203947.001]
  • [Cites] Gut. 1997 May;40(5):691-2 [9203954.001]
  • [Cites] Hum Pathol. 1997 Dec;28(12):1396-407 [9416697.001]
  • [Cites] J Natl Cancer Inst. 2001 Sep 5;93(17):1307-13 [11535705.001]
  • [Cites] Am J Pathol. 2002 Feb;160(2):529-36 [11839573.001]
  • [Cites] Am J Pathol. 2002 May;160(5):1823-30 [12000733.001]
  • [Cites] Cancer. 1998 Sep 1;83(5):896-900 [9731892.001]
  • [Cites] Curr Biol. 1999 Jan 28;9(2):R62-5 [10021355.001]
  • [Cites] J Clin Pathol. 1999 Jan;52(1):5-9 [10343605.001]
  • [Cites] Pathology. 1989 Apr;21(2):138-42 [2812873.001]
  • [Cites] Gut. 2000 Jul;47(1):43-9 [10861263.001]
  • [Cites] Gastroenterology. 2000 Aug;119(2):323-32 [10930367.001]
  • [Cites] Gastroenterology. 2000 Sep;119(3):854-65 [10982779.001]
  • [Cites] J Pathol. 2001 Mar;193(3):283-5 [11241405.001]
  • [Cites] Gastroenterology. 2001 Sep;121(3):599-611 [11522744.001]
  • [Cites] Am J Surg Pathol. 1987 Apr;11(4):323-7 [3565675.001]
  • [Cites] Gastroenterology. 2002 Sep;123(3):862-76 [12198712.001]
  • (PMID = 15793287.001).
  • [ISSN] 0002-9440
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
  • [Other-IDs] NLM/ PMC1602378
  •  go-up   go-down






Advertisement