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1. Kim R, Tsao R, Tan A, Byrne M, Almhanna K, Lazaryan A, Elson P, Pelley RJ: A single institution review of adjuvant therapy outcomes for resectable pancreatic adenocarcinoma: outcome and prognostic indicators. J Gastrointest Surg; 2010 Jul;14(7):1159-69
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  • [Title] A single institution review of adjuvant therapy outcomes for resectable pancreatic adenocarcinoma: outcome and prognostic indicators.
  • METHODS: Medical records were reviewed for 179 consecutive patients treated at The Cleveland Clinic with pancreaticoduodenectomy for resectable pancreatic adenocarcinoma from 1999 to 2006.
  • On univariate analysis, poor prognostic factors for overall survival were poorly differentiated histology, lymph node positive disease, elevated alkaline phosphatase, elevated total bilirubin, elevated AST, age at diagnosis >70, and high T stage.
  • On multivariate analysis, poorly differentiated histology (p = .001), age >70 (p = .007), lymph node involvement (> or = 3 positive vs <3, p = .03), and elevated LFTs (alkaline phosphatase and/or bilirubin and/or AST; p = .002) were independent predictors of survival.
  • [MeSH-major] Adenocarcinoma / therapy. Pancreatic Neoplasms / therapy

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  • (PMID = 20446118.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.1.3.1 / Alkaline Phosphatase; RFM9X3LJ49 / Bilirubin
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2. Yonemori K, Ando M, Shibata T, Katsumata N, Matsumoto K, Yamanaka Y, Kouno T, Shimizu C, Fujiwara Y: Tumor-marker analysis and verification of prognostic models in patients with cancer of unknown primary, receiving platinum-based combination chemotherapy. J Cancer Res Clin Oncol; 2006 Oct;132(10):635-42
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  • The ST-439 level was significantly higher in patients with histologically confirmed adenocarcinoma than in patients with poorly differentiated adenocarcinoma or poorly differentiated carcinoma.

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  • (PMID = 16791594.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; BG3F62OND5 / Carboplatin; EC 1.1.1.27 / L-Lactate Dehydrogenase; Q20Q21Q62J / Cisplatin
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3. Kodaira C, Osawa S, Mochizuki C, Sato Y, Nishino M, Yamada T, Takayanagi Y, Takagaki K, Sugimoto K, Kanaoka S, Furuta T, Ikuma M: A case of small bowel adenocarcinoma in a patient with Crohn's disease detected by PET/CT and double-balloon enteroscopy. World J Gastroenterol; 2009 Apr 14;15(14):1774-8
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  • [Title] A case of small bowel adenocarcinoma in a patient with Crohn's disease detected by PET/CT and double-balloon enteroscopy.
  • Small bowel adenocarcinoma (SBA) in patients with Crohn's disease (CD) is quite rare, difficult to diagnose without surgery, and has a poor prognosis.
  • An endoscopic forceps biopsy specimen showed poorly differentiated adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / etiology. Crohn Disease / complications. Endoscopy, Gastrointestinal / methods. Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / etiology. Intestine, Small / pathology

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  • (PMID = 19360924.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2668786
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4. Giuliani A, Demoro M, Corona M, Di Bari M, Ricciardulli T, Galati G, Ciardi A: Synchronous colon and gastric advanced carcinomas. J Exp Clin Cancer Res; 2005 Mar;24(1):155-8
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  • At histology, a poorly differentiated gastric adenocarcinoma with signet ring-cell component (pT2, pN0; stage IB) and a moderately differentiated colon adenocarcinoma with a tubulovillous component (pT3, pN1; stage III, Stage Dukes C) were revealed.

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  • (PMID = 15943046.001).
  • [ISSN] 0392-9078
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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5. Bono AV, Pannellini T, Liberatore M, Montironi R, Cunico SC, Cheng L, Sasso F, Musiani P, Iezzi M: Sorafenib's inhibition of prostate cancer growth in transgenic adenocarcinoma mouse prostate mice and its differential effects on endothelial and pericyte growth during tumor angiogenesis. Anal Quant Cytol Histol; 2010 Jun;32(3):136-45
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  • [Title] Sorafenib's inhibition of prostate cancer growth in transgenic adenocarcinoma mouse prostate mice and its differential effects on endothelial and pericyte growth during tumor angiogenesis.
  • OBJECTIVE: To evaluate Sorafenib's efficacy (60 mg/kg/d per os) in preventing the transformation of high grade prostate intraepithelial neoplasia (HGPIN) into adenocarcinoma (ADC) and in inhibiting the onset and progression of poorly differentiated carcinoma (PDC) in transgenic adenocarcinoma mouse prostate (TRAMP) mice.

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  • (PMID = 20701066.001).
  • [ISSN] 0884-6812
  • [Journal-full-title] Analytical and quantitative cytology and histology
  • [ISO-abbreviation] Anal. Quant. Cytol. Histol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antineoplastic Agents; 0 / Benzenesulfonates; 0 / Phenylurea Compounds; 0 / Pyridines; 25X51I8RD4 / Niacinamide; 9ZOQ3TZI87 / sorafenib
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6. Saito N, Hatori T, Murata N, Shibuya K, Mitsuda A, Hasegawa C, Akima M, Ikawa M, Nonaka H: A case of concomitant occurrence of struma ovarii and malignant transformation of cystic teratoma. Int J Surg Pathol; 2007 Jul;15(3):318-20
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  • The tumorous lesion of the cyst wall revealed a poorly differentiated adenocarcinoma.
  • The authors diagnosed that struma ovarii and other parats coexisted as a poorly differentiated adenocarcinoma that had arisen from a mature ovarian cystic teratoma.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Aged. Female. Gene Expression Regulation, Neoplastic. Humans. Keratin-7 / genetics. Keratin-7 / metabolism. Maximum Tolerated Dose

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  • (PMID = 17652549.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratin-7
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7. Ohtsubo K, Watanabe H, Yamada T, Tsuchiyama T, Mouri H, Yamashita K, Yasumoto K, Ikeda H, Nakanuma Y, Yano S: Cancer of unknown primary site in which tumor marker-oriented chemotherapy was effective and pancreatic cancer was finally confirmed at autopsy. Intern Med; 2009;48(18):1651-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Microscopic examination at autopsy revealed poorly differentiated adenocarcinoma in the pancreatic head, although a pancreatic mass was not clear macroscopically.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / drug therapy. Adenocarcinoma / metabolism. Adenocarcinoma / secondary. Antigens, Neoplasm / metabolism. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Autopsy. Biomarkers, Tumor / metabolism. Cisplatin / administration & dosage. Deoxycytidine / administration & dosage. Deoxycytidine / analogs & derivatives. Humans. Lung Neoplasms / diagnosis. Lung Neoplasms / drug therapy. Lung Neoplasms / metabolism. Lung Neoplasms / secondary. Lymphatic Metastasis. Male. Middle Aged

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  • (PMID = 19755768.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / DU-PAN-2 antigen, human; 0 / pancreatic associated antigen, SPan-1; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine; Q20Q21Q62J / Cisplatin
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8. Yanokura M, Banno K, Kawaguchi M, Hirao N, Hirasawa A, Susumu N, Tsukazaki K, Aoki D: Relationship of aberrant DNA hypermethylation of CHFR with sensitivity to taxanes in endometrial cancer. Oncol Rep; 2007 Jan;17(1):41-8
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  • Methylation-specific PCR (MSP) indicated aberrant hypermethylation of CHFR in 12.0% (6/50) of endometrial cancer specimens, and suggested that aberrant hypermethylation is significantly more frequent in poorly differentiated adenocarcinoma (G3) (p<0.05).
  • This may be particularly important in poorly differentiated adenocarcinoma (G3), which is known to have a poor prognosis.

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  • (PMID = 17143476.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / CHFR protein, human; 0 / Cell Cycle Proteins; 0 / Neoplasm Proteins; 0 / Taxoids; 15H5577CQD / docetaxel; 776B62CQ27 / decitabine; 80168379AG / Doxorubicin; M801H13NRU / Azacitidine; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin
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9. Ito S, Kawano Y, Katakura H, Takenaka K, Adachi M, Sasaki M, Shimizu K, Ikenaka K, Wada H, Tanaka F: Expression of MAGE-D4, a novel MAGE family antigen, is correlated with tumor-cell proliferation of non-small cell lung cancer. Lung Cancer; 2006 Jan;51(1):79-88
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  • In addition, a high MAGE-D4 expression was more frequently seen in squamous cell carcinoma than in adenocarcinoma (p=0.008), and less frequently in well-differentiated tumors than in moderately to poorly differentiated tumors (p=0.036).

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  • (PMID = 16225959.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / MAGED1 protein, human; 0 / Neoplasm Proteins; 0 / RNA, Messenger
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10. Kawaguchi A, Nagao S, Takebayashi K, Higashiyama M, Komoto S, Hokari R, Miura S: Long-term outcome of endoscopic semiconductive diode laser irradiation therapy with injection of indocyanine green for early gastric cancer. J Gastroenterol Hepatol; 2008 Aug;23(8 Pt 1):1193-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histological diagnoses were eight cases (nine lesions) of well-differentiated adenocarcinoma, three cases of moderately differentiated adenocarcinoma and two cases of poorly differentiated adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / surgery. Gastroscopy. Laser Therapy. Lasers, Semiconductor / therapeutic use. Stomach Neoplasms / surgery

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  • (PMID = 18624897.001).
  • [ISSN] 1440-1746
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Coloring Agents; IX6J1063HV / Indocyanine Green
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11. Ruemmele P, Dietmaier W, Terracciano L, Tornillo L, Bataille F, Kaiser A, Wuensch PH, Heinmoeller E, Homayounfar K, Luettges J, Kloeppel G, Sessa F, Edmonston TB, Schneider-Stock R, Klinkhammer-Schalke M, Pauer A, Schick S, Hofstaedter F, Baumhoer D, Hartmann A: Histopathologic features and microsatellite instability of cancers of the papilla of vater and their precursor lesions. Am J Surg Pathol; 2009 May;33(5):691-704
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  • The most common histologic subtype was intestinal (46.5%), followed by pancreatobiliary (23.5%), poorly differentiated adenocarcinomas (12.9%), intestinal-mucinous (8.2%), and invasive papillary carcinomas (5.3%).
  • [MeSH-minor] Adaptor Proteins, Signal Transducing / genetics. Adenocarcinoma / genetics. Adenocarcinoma / pathology. Adenocarcinoma, Mucinous / genetics. Adenocarcinoma, Mucinous / pathology. Adult. Aged. Aged, 80 and over. Carcinoma, Papillary / genetics. Carcinoma, Papillary / pathology. Cell Differentiation. DNA Methylation. DNA-Binding Proteins / genetics. Europe. Female. Gene Deletion. Genotype. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Male. Middle Aged. MutS Homolog 2 Protein / genetics. Neoplasm Invasiveness. Neoplasm Staging. Nuclear Proteins / genetics. Phenotype. Polymerase Chain Reaction. Promoter Regions, Genetic. Proportional Hazards Models. Risk Assessment. Treatment Outcome

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  • (PMID = 19252434.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein; 0 / MLH1 protein, human; 0 / Nuclear Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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12. Baloch ZW, LiVolsi VA: Unusual tumors of the thyroid gland. Endocrinol Metab Clin North Am; 2008 Jun;37(2):297-310, vii
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  • Other primary epithelial tumors include medullary carcinoma, mixed medullary and follicular carcinomas, insular and poorly differentiated carcinoma, anaplastic carcinoma, and the least common squamous carcinoma and related tumors.
  • [MeSH-minor] Adenocarcinoma, Follicular / pathology. Carcinoma, Papillary / pathology. Disease Progression. Humans. Neoplasm Staging. Prognosis. Thyroid Gland / pathology

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  • (PMID = 18502328.001).
  • [ISSN] 0889-8529
  • [Journal-full-title] Endocrinology and metabolism clinics of North America
  • [ISO-abbreviation] Endocrinol. Metab. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 62
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13. Dodiuk-Gad R, Ziv M, Loven D, Schafer J, Shani-Adir A, Dyachenko P, Rozenman D: Sister Mary Joseph's nodule as a presenting sign of internal malignancy. Skinmed; 2006 Sep-Oct;5(5):256-8
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  • A skin biopsy from the nodule showed mucinous adenocarcinoma.
  • The mass was removed and diagnosed as a poorly differentiated adenocarcinoma, staining positively for carcinoembryonic antigen, and negatively for CK20, CK7, prostate-specific antigen, and prostatic acid phosphatase.
  • On bronchoscopy, it was found to be an invasive adenocarcinoma, consistent with a primary tumor of the lung.
  • The patient died 3 weeks later, 9 months after the diagnosis of adenocarcinoma of the lung.

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  • (PMID = 16957443.001).
  • [ISSN] 1540-9740
  • [Journal-full-title] Skinmed
  • [ISO-abbreviation] Skinmed
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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14. Sidoruk AA, Novik VI, Urmancheeva AF: [Clinico-morphological diagnosis of adenocarcinoma in situ of the cervix uteri]. Vopr Onkol; 2009;55(6):733-9
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  • [Title] [Clinico-morphological diagnosis of adenocarcinoma in situ of the cervix uteri].
  • Clinical and morphological investigation involved 57 patients with adenocarcinoma in situ of the cervix uteri (poorly-differentiated (precancerous) cell carcinoma in situ (PAIS)--30; adenocarcinoma in situ (AIS)--27).
  • [MeSH-major] Adenocarcinoma / diagnosis. Cervical Intraepithelial Neoplasia / diagnosis. Uterine Cervical Neoplasms / diagnosis


15. Kitamura YH, Shirahata A, Sakata M, Goto T, Mizukami H, Saito M, Ishibashi K, Kigawa G, Nemoto H, Sanada Y, Hibi K: Frequent methylation of Vimentin in well-differentiated gastric carcinoma. Anticancer Res; 2009 Jun;29(6):2227-9
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  • [Title] Frequent methylation of Vimentin in well-differentiated gastric carcinoma.
  • CONCLUSION: In gastric carcinomas, well-differentiated adenocarcinoma was significantly methylated compared to poorly differentiated.
  • [MeSH-major] Adenocarcinoma / genetics. Cell Differentiation. DNA Methylation. Stomach Neoplasms / genetics. Stomach Neoplasms / pathology. Vimentin / genetics

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  • (PMID = 19528485.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Vimentin
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16. Gao YJ, Xin Y, Zhang JJ, Zhou J: Mechanism and pathobiologic implications of CHFR promoter methylation in gastric carcinoma. World J Gastroenterol; 2008 Aug 28;14(32):5000-7
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  • The CHFR gene methylation in poorly differentiated GC samples was significantly higher than that in well-differentiated GC samples (P = 0.014).
  • Moreover, the negative CHFR protein expression rate in paraffin-embedded GC samples was 55.07% (38/69), the positive rate in poorly differentiated GC samples was 36.73% (18/49), which was significantly lower than 65.00% (13/20) in well-differentiated GC samples (c2 = 4.586, P = 0.032).
  • [MeSH-major] Adenocarcinoma / genetics. Cell Cycle Proteins / genetics. DNA Methylation. Gene Expression Regulation, Neoplastic. Neoplasm Proteins / genetics. Stomach Neoplasms / genetics

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  • (PMID = 18763281.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / CHFR protein, human; 0 / Cell Cycle Proteins; 0 / Neoplasm Proteins
  • [Other-IDs] NLM/ PMC2742926
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17. Hiltzik D, Carlson DL, Tuttle RM, Chuai S, Ishill N, Shaha A, Shah JP, Singh B, Ghossein RA: Poorly differentiated thyroid carcinomas defined on the basis of mitosis and necrosis: a clinicopathologic study of 58 patients. Cancer; 2006 Mar 15;106(6):1286-95
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  • [Title] Poorly differentiated thyroid carcinomas defined on the basis of mitosis and necrosis: a clinicopathologic study of 58 patients.
  • BACKGROUND: Poorly differentiated thyroid carcinomas (PDTC) occupy an intermediate position at the prognostic level on the spectrum of thyroid carcinoma progression.
  • [MeSH-minor] Adenocarcinoma, Follicular / pathology. Adenocarcinoma, Follicular / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Papillary / pathology. Carcinoma, Papillary / surgery. Child. Disease-Free Survival. Female. Humans. Male. Middle Aged. Necrosis. Neoplasm Invasiveness / pathology. Neoplasm Metastasis. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Prognosis. Retrospective Studies. Risk Factors. Survival Rate. Treatment Outcome

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  • [Copyright] (c) 2006 American Cancer Society.
  • (PMID = 16470605.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Chung AC, Zhou S, Liao L, Tien JC, Greenberg NM, Xu J: Genetic ablation of the amplified-in-breast cancer 1 inhibits spontaneous prostate cancer progression in mice. Cancer Res; 2007 Jun 15;67(12):5965-75
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  • Surprisingly, when prostate tumorigenesis was induced by the SV40 transgene in transgenic adenocarcinoma of the mouse prostate (TRAMP) mice, AIB1 expression was observed in certain epithelial cells of the prostate intraepithelial neoplasia (PIN) and well-differentiated carcinoma and in almost all cells of the poorly differentiated carcinoma.
  • After AIB1 was genetically inactivated in AIB1-/-/TRAMP mice, the progression of prostate tumorigenesis in most AIB1-/-/TRAMP mice was arrested at the well-differentiated carcinoma stage.
  • In contrast, AIB1-/-/TRAMP mice only exhibited PIN and early-stage well-differentiated carcinoma by 39 weeks.
  • Our results indicate that induction of AIB1 expression in partially transformed epithelial cells is essential for progression of prostate tumorigenesis into poorly differentiated carcinoma.

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  • (PMID = 17575167.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / DK58242; United States / NIDDK NIH HHS / DK / DK058242-05; United States / NCI NIH HHS / CA / CA119689-03; United States / NCI NIH HHS / CA / CA112403; United States / NCI NIH HHS / CA / R01 CA112403-02; United States / NCI NIH HHS / CA / CA112403-02; United States / NIDDK NIH HHS / DK / R01 DK058242-05; United States / NCI NIH HHS / CA / R01 CA119689-03; United States / NCI NIH HHS / CA / CA119689; United States / NCI NIH HHS / CA / R01 CA112403; United States / NIDDK NIH HHS / DK / R01 DK058242; United States / NCI NIH HHS / CA / R01 CA119689
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Androgen; 0 / Trans-Activators; EC 2.3.1.48 / Histone Acetyltransferases; EC 2.3.1.48 / Ncoa3 protein, mouse; EC 2.3.1.48 / Nuclear Receptor Coactivator 3
  • [Other-IDs] NLM/ NIHMS50339; NLM/ PMC2898573
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19. Zhang LL, Shao SL, Wu Y: [Expressions of osteopontin and B7-H4 in epithelial ovarian neoplasm and their significance]. Chin J Cancer; 2010 Jan;29(1):25-9
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  • The positive rates of OPN and B7-H4 were significantly higher in poorly differentiated ovarian cancer than in medium and highly differentiated ovarian cancer (P<0.05), and the levels of expression were significantly lower in tissue at stages I and III of ovarian cancer than in stages III and IV (P<0.05).
  • [MeSH-minor] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / metabolism. Adenocarcinoma, Mucinous / pathology. Adolescent. Adult. Aged. Female. Gene Expression Regulation, Neoplastic. Humans. Lymphatic Metastasis. Middle Aged. Neoplasm Staging. Ovary / metabolism. Young Adult

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  • (PMID = 20038306.001).
  • [ISSN] 1000-467X
  • [Journal-full-title] Chinese journal of cancer
  • [ISO-abbreviation] Chin J Cancer
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / SPP1 protein, human; 0 / V-Set Domain-Containing T-Cell Activation Inhibitor 1; 106441-73-0 / Osteopontin; Ovarian epithelial cancer
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20. Scabini S, Rimini E, Romairone E, Scordamaglia R, Vallarino L, Giasotto V, Ferro C, Ferrando V: Urachal tumour: case report of a poorly understood carcinoma. World J Surg Oncol; 2009;7:82
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  • [Title] Urachal tumour: case report of a poorly understood carcinoma.
  • Histological examination detected poor-differentiated adenocarcinoma, which had invaded the urinary bladder.
  • [MeSH-major] Adenocarcinoma / pathology. Urachus / pathology. Urinary Bladder Neoplasms / pathology

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  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
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21. Tokairin Y, Kakinuma S, Arai M, Nishimura M, Okamoto M, Ito E, Akashi M, Miki Y, Kawano T, Iwai T, Shimada Y: Accelerated growth of intestinal tumours after radiation exposure in Mlh1-knockout mice: evaluation of the late effect of radiation on a mouse model of HNPCC. Int J Exp Pathol; 2006 Apr;87(2):89-99
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  • GIT included not only well differentiated adenocarcinomas but also poorly differentiated and mucinous adenocarcinomas, suggesting that this mouse is a good model for HNPCC.
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Adenocarcinoma / etiology. Animals. Base Pair Mismatch / genetics. Carrier Proteins / genetics. Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. Colorectal Neoplasms, Hereditary Nonpolyposis / pathology. Colorectal Neoplasms, Hereditary Nonpolyposis / radiotherapy. Disease Models, Animal. Disease Progression. Genes, Neoplasm / genetics. Immunohistochemistry / methods. Lymphoma / etiology. Mice. Mice, Knockout. Mutation / genetics. Neoplasm Proteins / analysis. Nuclear Proteins / deficiency. Nuclear Proteins / genetics. Radiotherapy / adverse effects. Receptors, Transforming Growth Factor beta / genetics. Thymus Neoplasms / etiology. Transforming Growth Factor beta / analysis. Transforming Growth Factor beta2. Tumor Suppressor Protein p53 / analysis. beta Catenin / analysis

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  • (PMID = 16623753.001).
  • [ISSN] 0959-9673
  • [Journal-full-title] International journal of experimental pathology
  • [ISO-abbreviation] Int J Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / Mlh1 protein, mouse; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Receptors, Transforming Growth Factor beta; 0 / Transforming Growth Factor beta; 0 / Transforming Growth Factor beta2; 0 / Tumor Suppressor Protein p53; 0 / beta Catenin
  • [Other-IDs] NLM/ PMC2517356
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22. Nishio S, Koyanagi T, Miyabe K, Kuromatsu H: [Two cases of multidrug-resistant recurrent endometrial cancer successfully treated with medroxyprogesterone acetate (MPA)]. Gan To Kagaku Ryoho; 2010 Apr;37(4):735-8
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  • The first patient with stage IVb moderately-differentiated endometrioid adenocarcinoma of the uterine corpus underwent initial operation and postoperative chemotherapy followed by maintenance chemotherapy.
  • The second patient with stage IIIc poorly-differentiated endometrioid adenocarcinoma of the uterine corpus developed lung metastases 14 months after the initial operation and postoperative chemotherapy.

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  • (PMID = 20414038.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; C2QI4IOI2G / Medroxyprogesterone Acetate
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23. Mirabello L, Garcia-Closas M, Cawthon R, Lissowska J, Brinton LA, Pepłońska B, Sherman ME, Savage SA: Leukocyte telomere length in a population-based case-control study of ovarian cancer: a pilot study. Cancer Causes Control; 2010 Jan;21(1):77-82
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  • METHODS: We investigated leukocyte telomere length in 99 women with serous ovarian adenocarcinoma and 100 age-matched cancer-free controls enrolled in a population-based case-control study.
  • Strongest associations were found for subjects with poorly differentiated carcinomas (OR = 4.89, 95% CI 1.93-12.34).
  • CONCLUSIONS: This study shows that short leukocyte telomeres are associated with serous ovarian adenocarcinoma.

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  • (PMID = 19784860.001).
  • [ISSN] 1573-7225
  • [Journal-full-title] Cancer causes & control : CCC
  • [ISO-abbreviation] Cancer Causes Control
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA082838; United States / Intramural NIH HHS / / Z01 CP010190-02; United States / NCI NIH HHS / CA / CA82838
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ NIHMS301770; NLM/ PMC3130499
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24. Handa Y, Kato H, Kaneuchi M, Saitoh Y, Yamashita K: High-grade broad ligament cancer of müllerian origin: immunohistochemical analysis of a case and review of the literature. Int J Gynecol Cancer; 2007 May-Jun;17(3):705-9
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  • This case study reports a 49-year-old nulliparous woman who, during her follow-up for breast cancer, demonstrated a 39- x 32-mm solid and poorly differentiated adenocarcinoma within the broad ligament of the right adnexa.

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  • (PMID = 17504384.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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25. Lachinski AJ, Stefaniak T, Kobiela J, Connor S, Gruca Z, Sledzinski Z: New prognostic scales LAST-1 and LAST-2: supporting prediction and staging of thyroid cancer. World J Surg; 2006 Mar;30(3):309-20
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  • Although the results of surgical treatment of the highly differentiated (follicular and papillary) tumors seem to be satisfactory, treatment of the poorly differentiated (medullary and anaplastic) tumor still demands clinical and basic investigations.
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Carcinoma, Papillary / pathology. Neoplasm Staging / methods. Thyroid Neoplasms / pathology

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  • (PMID = 16479347.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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26. Bigsby GE 4th, Holloway RW, Weppelman B, Reynolds RB, Williams B: Endometroid adenocarcinoma of the uterus with cardiac metastasis. A case report and six-year follow-up. Gynecol Oncol; 2005 Apr;97(1):256-9
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  • [Title] Endometroid adenocarcinoma of the uterus with cardiac metastasis. A case report and six-year follow-up.
  • She underwent exploration of the heart with debulking which revealed a metastatic poorly differentiated epithelial tumor.
  • Further work-up with a dilation and curettage revealed a poorly differentiated EC.
  • [MeSH-major] Adenocarcinoma / secondary. Endometrial Neoplasms / pathology. Heart Neoplasms / secondary

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  • (PMID = 15790471.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Osunkoya AO, Netto GJ, Epstein JI: Colorectal adenocarcinoma involving the prostate: report of 9 cases. Hum Pathol; 2007 Dec;38(12):1836-41
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  • [Title] Colorectal adenocarcinoma involving the prostate: report of 9 cases.
  • We present 9 consult cases, the largest series to date, of colorectal adenocarcinoma involving the prostate.
  • Two cases involved the prostate after the recurrence of rectal adenocarcinoma at the anastomotic site of the previous colonic resection.
  • In most cases, the tumors were typical moderately differentiated with occasional poorly differentiated foci.
  • There are critical therapeutic and prognostic implications for distinguishing between prostatic adenocarcinoma and colorectal carcinoma involving the prostate.
  • Colorectal adenocarcinoma should be considered on prostate sampling when carcinoma exhibits either "dirty" necrosis, tall columnar epithelium with mucin production, mucin-positive signet-ring cells, villous architecture, or associated inflammation.
  • [MeSH-major] Adenocarcinoma / secondary. Colorectal Neoplasms / pathology. Prostatic Neoplasms / secondary

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  • (PMID = 17868775.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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28. Lax S: [Serous genital carcinoma: molecular pathogenesis and the role of tubal fimbria]. Pathologe; 2009 Dec;30 Suppl 2:210-6
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  • Currently, two distinctive molecular genetic pathways are distinguished for serous tumorigenesis: type I tumors are typically well differentiated and gradually develop from cystadenoma through borderline tumor to low grade carcinoma and are characterized by B-raf and K-ras mutations, whereas the poorly differentiated type II tumors develop from intraepithelial carcinoma and show p53 mutations.
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Apoptosis Regulatory Proteins. BRCA1 Protein / analysis. BRCA1 Protein / genetics. BRCA2 Protein / analysis. BRCA2 Protein / genetics. Cell Transformation, Neoplastic / genetics. Cell Transformation, Neoplastic / pathology. Cystadenoma / genetics. Cystadenoma / pathology. DNA Mutational Analysis. Fallopian Tubes / pathology. Female. Genitalia, Female / pathology. Germ-Line Mutation. Humans. Neoplasm Staging. Ovary / pathology. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 19859709.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / BLID protein, human; 0 / BRCA1 Protein; 0 / BRCA1 protein, human; 0 / BRCA2 Protein; 0 / BRCA2 protein, human; 0 / Biomarkers, Tumor; 0 / Tumor Suppressor Protein p53
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29. Horio H, Hijima T, Sakaguchi K, Kuwabara K: Mediastinal Castleman disease associated with pulmonary carcinoma, mimicking N2 stage lung cancer. Jpn J Thorac Cardiovasc Surg; 2005 May;53(5):286-9
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  • Final histopathological diagnosis was a poorly differentiated adenocarcinoma of the lung staged as T1NOMO and a coexistent localized hyaline-vascular type of Castleman disease.
  • [MeSH-major] Adenocarcinoma / epidemiology. Giant Lymph Node Hyperplasia / epidemiology. Lung Neoplasms / epidemiology. Mediastinal Diseases / epidemiology

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  • (PMID = 15952326.001).
  • [ISSN] 1344-4964
  • [Journal-full-title] The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi
  • [ISO-abbreviation] Jpn. J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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30. Cadière GB, Himpens J, Torres R, Dapri G, Bosschaerts T, Karler C, Haller A: Multimedia article. Entirely thoracoscopic pneumonectomy using the prone position: a new technique. Surg Endosc; 2005 Sep;19(9):1282-3
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  • Biopsy showed invasive adenocarcinoma, and a CT scan of the neck and head was significant for tumoral infiltration of the cervical esophagus and retropharyngeal space.
  • The pathology report confirmed the presence of invasive, poorly differentiated adenocarcinoma.
  • The esophagetomy specimen showed fairly wide differentiated keratinizing of the spinocellular epithelioma with invasion of both pyriform sinuses and both sides of the glottis.

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  • (PMID = 16249969.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article; Video-Audio Media
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31. Hsu CP, Hsia JY, Chang GC, Chuang CY, Shai SE, Yang SS, Lee MC, Kwan PC: Surgical-pathologic factors affect long-term outcomes in stage IB (pT2 N0 M0) non-small cell lung cancer: a heterogeneous disease. J Thorac Cardiovasc Surg; 2009 Aug;138(2):426-33
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  • RESULTS: Tumor types included adenocarcinoma/bronchioloalveolar carcinoma in 142, squamous cell carcinoma in 100, and others in 30.
  • Cell differentiations were classified as well, moderately, and poorly differentiated in 23, 151, and 92 cases, respectively.
  • Good prognostic factors using univariate analysis included female gender, nonlimited resection, well-differentiated tumor, no angiolymphatic invasion, smaller size (<or=3 cm), and numbers of nodes retrieved (>14 nodes).
  • However, the Cox proportional hazard model revealed female gender, well-differentiated tumor, no pleural involvement, no angiolymphatic invasion, and more than 14 nodes retrieved as independent good prognostic factors.

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  • (PMID = 19619791.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. Sato S, Mukai M: Significance of occult neoplastic cells on tumor metastasis: a case report of gastric cancer. Diagn Pathol; 2010;5:14
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  • RESULTS: Postoperative examination of the stomach disclosed an advanced, poorly differentiated adenocarcinoma with frequent lymph node metastases.

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  • (PMID = 20178643.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; U3P01618RT / Fluorouracil
  • [Other-IDs] NLM/ PMC2843646
  • [General-notes] NLM/ Original DateCompleted: 20100609
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33. Tateishi Y, Nakanishi Y, Taniguchi H, Shimoda T, Umemura S: Pathological prognostic factors predicting lymph node metastasis in submucosal invasive (T1) colorectal carcinoma. Mod Pathol; 2010 Aug;23(8):1068-72
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  • All 46 cases of lymph node metastasis showed at least one of the following findings: lymphatic invasion, moderately or poorly differentiated tumor grade, tumor budding, or complete disruption of the muscularis mucosa due to tumor invasion.
  • Patients with submucosal invasive colorectal carcinoma that show at least one of three factors--lymphatic invasion, moderately or poorly differentiated tumor grade, or tumor budding--are at high risk for lymph node metastasis.
  • [MeSH-major] Adenocarcinoma / secondary. Colorectal Neoplasms / pathology. Intestinal Mucosa / pathology. Lymph Nodes / pathology

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  • (PMID = 20473277.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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34. Kanai M, Torii A, Hamada A, Endo Y, Takeda Y, Yamakawa M, Hikita H, Nishikawa H, Ochi J, Miura K, Noguchi M, Kashu I, Sakurai T: Pure gastric yolk sac tumor that was diagnosed after curative resection: case report and review of literature. Int J Gastrointest Cancer; 2005;35(1):77-81
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  • Preoperative diagnosis was poorly differentiated adenocarcinoma in the cardia of stomach without apparent metastasis.
  • Five out of six cases are accompanied by components of adenocarcinoma, and our present case is the second report of pure gastric yolk sac tumor to the best of our knowledge.
  • [MeSH-major] Adenocarcinoma / surgery. Endodermal Sinus Tumor / pathology. Endodermal Sinus Tumor / surgery. Stomach Neoplasms / pathology. Stomach Neoplasms / surgery

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  • (PMID = 15722577.001).
  • [ISSN] 1537-3649
  • [Journal-full-title] International journal of gastrointestinal cancer
  • [ISO-abbreviation] Int J Gastrointest Cancer
  • [Language] eng
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35. Power D, Lagunes DR: Adenocarcinoma of unknown primary in a 20-year-old African American male. Clin Genitourin Cancer; 2009 Aug;7(2):E45-8
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  • [Title] Adenocarcinoma of unknown primary in a 20-year-old African American male.
  • Lung biopsy revealed poorly differentiated adenocarcinoma positive for cytokeratin 7.
  • [MeSH-major] Adenocarcinoma / diagnosis. Kidney Medulla / pathology. Kidney Neoplasms / diagnosis. Neoplasms, Unknown Primary / diagnosis

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  • (PMID = 19692325.001).
  • [ISSN] 1938-0682
  • [Journal-full-title] Clinical genitourinary cancer
  • [ISO-abbreviation] Clin Genitourin Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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36. Nguyen NC, Sayed MM, Taalab K, Osman MM: Spinal cord metastases from lung cancer: detection with F-18 FDG PET/CT. Clin Nucl Med; 2008 May;33(5):356-8
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  • She underwent a left upper lobectomy in June 2005 revealing moderately poorly differentiated adenocarcinoma (pT3N0M0) and subsequent chemotherapy completed December 2005.

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  • (PMID = 18431157.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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37. Hassan KA, Chen G, Kalemkerian GP, Wicha MS, Beer DG: An embryonic stem cell-like signature identifies poorly differentiated lung adenocarcinoma but not squamous cell carcinoma. Clin Cancer Res; 2009 Oct 15;15(20):6386-90
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  • [Title] An embryonic stem cell-like signature identifies poorly differentiated lung adenocarcinoma but not squamous cell carcinoma.
  • PURPOSE: An embryonic stem cell (ESC) profile correlates with poorly differentiated breast, bladder, and glioma cancers.
  • EXPERIMENTAL DESIGN: Microarray gene expression analysis was done using Affymetrix Human Genome U133A on 443 samples of human lung adenocarcinoma and 130 samples of squamous cell carcinoma (SCC).
  • RESULTS: Our analysis showed that an increased expression of the ESC gene set and a decreased expression of the Polycomb target gene set identified poorly differentiated lung adenocarcinoma.
  • In addition, this gene expression signature was associated with markers of poor prognosis and worse overall survival in lung adenocarcinoma.
  • CONCLUSIONS: This work suggests that not all poorly differentiated non-small cell lung cancers exhibit a gene expression profile similar to that of ESC, and that other characteristics may play a more important role in the determination of differentiation and survival in SCC of the lung.
  • [MeSH-major] Adenocarcinoma / genetics. Carcinoma, Squamous Cell / genetics. Lung Neoplasms / genetics

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  • (PMID = 19808871.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / K08 CA158425; United States / NCI NIH HHS / CA / P30 CA046592; United States / NCI NIH HHS / CA / P30 CA046592-14; United States / NCI NIH HHS / CA / 5P30 CA46592
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS143924; NLM/ PMC2787085
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38. Wu Y, Yao LQ, Cheng J, Tian H: [Diagnostic value of bone marrow biopsy for bone marrow metastatic tumor with unknown primary tumor site]. Nan Fang Yi Ke Da Xue Xue Bao; 2010 May;30(5):1069-71
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  • Twenty patients were identified to have poorly differentiated adenocarcinomas, 6 had mucinous adenocarcinomas, 6 had mucinous carcinomas, 4 had poorly differentiated squamous cell carcinomas, and 2 had melanoma.
  • [MeSH-major] Adenocarcinoma / secondary. Bone Marrow Examination / methods. Bone Marrow Neoplasms / diagnosis. Bone Marrow Neoplasms / secondary. Neoplasms, Unknown Primary / diagnosis

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  • (PMID = 20501396.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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39. Zheng HC, Xu XY, Yu M, Takahashi H, Masuda S, Takano Y: The role of Reg IV gene and its encoding product in gastric carcinogenesis. Hum Pathol; 2010 Jan;41(1):59-69
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  • Although the biologic function of Reg IV is poorly understood, it has been reported that Reg IV is a potent activator of the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon cancer cells and closely linked with the inhibition of apoptosis.
  • Among histologic subtypes of the World Health Organization, signet ring cell carcinoma more frequently expressed Reg IV than the others (P < .05), whereas it is the converse for the poorly differentiated group (P < .05).
  • [MeSH-major] Adenocarcinoma / genetics. Gene Expression Regulation, Neoplastic. Lectins, C-Type / genetics. Stomach Neoplasms / genetics


40. Yoshimura F, Sakurai Y, Inaba K, Ishida Y, Taniguchi K, Isogaki J, Kanaya S, Komori Y, Uyama I: [Clinical characteristics of cases showing complete regression of the primary tumor after S-1 combined with cisplatin administered as neoadjuvant chemotherapy in advanced gastric carcinoma]. Gan To Kagaku Ryoho; 2010 Nov;37(11):2087-92
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  • Five of 9 cases were solid-type poorly-differentiated adenocarcinoma (por1), and the incidence of responders was the highest in patients with por1.
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / pathology. Aged. Antineoplastic Agents / administration & dosage. Cisplatin / administration & dosage. Drug Combinations. Female. Humans. Male. Middle Aged. Neoadjuvant Therapy. Oxonic Acid / administration & dosage. Tegafur / administration & dosage. Treatment Outcome

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  • (PMID = 21084805.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; Q20Q21Q62J / Cisplatin
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41. Hunt JL: Unusual thyroid tumors: a review of pathologic and molecular diagnosis. Expert Rev Mol Diagn; 2005 Sep;5(5):725-34
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  • These less common thyroid tumors include tall cell and cribriform-morular variants of papillary carcinoma, hyalinizing trabecular tumor, mucoepidermoid and sclerosing mucoepidermoid carcinoma with eosinophilia, poorly differentiated (insular) carcinoma, and undifferentiated (anaplastic) carcinoma.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / metabolism. Cell Differentiation. Humans

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  • (PMID = 16149875.001).
  • [ISSN] 1744-8352
  • [Journal-full-title] Expert review of molecular diagnostics
  • [ISO-abbreviation] Expert Rev. Mol. Diagn.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 116
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42. Park JS, Yoon DS, Kim KS, Choi JS, Lee WJ, Chi HS, Kim BR: Factors influencing recurrence after curative resection for ampulla of Vater carcinoma. J Surg Oncol; 2007 Mar 15;95(4):286-90
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  • In the early recurrence group, ulcer formation tumors and poorly differentiated tumors were more common in comparison with the late recurrence group.
  • Also, the fact that a higher probability of recurrence is anticipated in cases of ulcer formation and poorly differentiated tumors, there exists a need for a close-up follow-up program.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Duodenal Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Pancreatic Neoplasms / surgery

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 17326125.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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43. Ehren K, Lamberti C, Poetzsch B, Majores M, Strach K, Sauerbruch T, Wasmuth JC: Massive hypercoagulable state despite full-dose anticoagulant treatment in a patient with occult malignancy: considerations concerning chemotherapy without definitive diagnosis. BMJ Case Rep; 2010;2010
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  • The autopsy showed a poorly differentiated adenocarcinoma in the middle lobe of the right lung.
  • [MeSH-major] Adenocarcinoma / complications. Anticoagulants / therapeutic use. Blood Coagulation Disorders / drug therapy. Blood Coagulation Disorders / etiology. Lung Neoplasms / complications

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  • (PMID = 22753159.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anticoagulants
  • [Other-IDs] NLM/ PMC3027077
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44. Aihara R, Mochiki E, Ohotake S, Kamiyama Y, Ohono T, Kuwano H, Kurokawa K, Suzuki K: Peritoneal recurrence of gastric cancer with mucin phenotype 12 years after curative resection: report of a case. Surg Today; 2007;37(4):325-9
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  • We performed total nephroureterectomy and cystectomy for urinary tract cancers, but histological examination of the resected specimen revealed poorly differentiated adenocarcinoma with severe fibrosis, resembling the gastric cancer resected 12 years earlier.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Adenocarcinoma, Mucinous / surgery. Carcinoma, Signet Ring Cell / pathology. Carcinoma, Signet Ring Cell / surgery. Stomach Neoplasms / pathology. Stomach Neoplasms / surgery. Urologic Neoplasms / secondary. Urologic Neoplasms / surgery

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  • (PMID = 17387567.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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45. Tamura H, Ohtsuka M, Washiro M, Kimura F, Shimizu H, Yoshidome H, Kato A, Seki N, Miyazaki M: Reg IV expression and clinicopathologic features of gallbladder carcinoma. Hum Pathol; 2009 Dec;40(12):1686-92
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  • Expression was more frequently observed in well to moderately differentiated than in poorly differentiated adenocarcinomas and significantly correlated with expression of caudal-related homeobox transcription factor (a candidate for involvement in the induction of intestinal metaplasia).
  • [MeSH-major] Adenocarcinoma / metabolism. Gallbladder Neoplasms / metabolism. Lectins, C-Type / biosynthesis

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  • (PMID = 19716164.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / Lectins, C-Type; 0 / REG4 protein, human
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46. Nanashima A, Sumida Y, Tomoshige K, Takeshita H, Shibata K, Sawai T, Yasutake T, Kinoshita N, Hayashi T, Nakanuma Y, Nagayasu T: A case of intraductal papillary neoplasm of the bile duct with stromal invasion. Case Rep Gastroenterol; 2008;2(3):314-20
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  • Here we report a case of IPNB in whom the poorly differentiated component deeply infiltrated the bile duct wall.
  • Histologic finding showed papillary adenocarcinoma in the surface layer superficially extending to the epithelium of the surrounding bile duct.
  • In the subserosal layer, the tumor represented poorly differentiated adenocarcinoma.

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  • (PMID = 21490862.001).
  • [ISSN] 1662-0631
  • [Journal-full-title] Case reports in gastroenterology
  • [ISO-abbreviation] Case Rep Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3075190
  • [Keywords] NOTNLM ; Bile duct / Intraductal papillary neoplasm / Right hepatectomy / Superficial extension
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47. Stewart SL, Wike JM, Kato I, Lewis DR, Michaud F: A population-based study of colorectal cancer histology in the United States, 1998-2001. Cancer; 2006 Sep 1;107(5 Suppl):1128-41
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  • Compared with other adenocarcinomas, signet ring cell tumors were more often poorly differentiated and were at distant stage at diagnosis.
  • Carcinoid tumors and sarcomas were mainly poorly differentiated and were at localized stage at diagnosis.
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adolescent. Adult. Aged, 80 and over. Carcinoma / epidemiology. Carcinoma, Squamous Cell / epidemiology. Child. Child, Preschool. Ethnic Groups. Female. Humans. Incidence. Infant. Male. Middle Aged. Population Surveillance. Registries. Sarcoma / epidemiology. United States / epidemiology

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  • (PMID = 16802325.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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48. Bazas VM, Lukyanova NY, Lisovenko GS, Rozumiy DO, Potebnya GP: Postoperative autovaccinotherapy for patients with gastric cancer and expression of some proteins in tumor tissue. Exp Oncol; 2009 Sep;31(3):182-4
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  • PATIENTS AND METHODS: 150 patients with histologically proven adenocarcinoma of the stomach of stages II, III or IV were enrolled into study.
  • CONCLUSION: It was determined that the best effect of AV application is observed in patients with category capital TE, Cyrillic3-4, poorly-differentiated tumors, metastases in lymph nodes (N1-2), but without distant metastases (capital EM, Cyrillic0).
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / therapy. Female. Humans. Immunoenzyme Techniques. Lymphatic Metastasis. Male. Neoplasm Staging. Postoperative Care. Prognosis. Proto-Oncogene Proteins c-bcl-2 / metabolism. Receptor, Epidermal Growth Factor / metabolism. Receptor, ErbB-2 / metabolism. Survival Rate. Tumor Suppressor Protein p53 / metabolism. Vaccination. Vascular Endothelial Growth Factor A / metabolism. beta Catenin / metabolism

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  • (PMID = 19783961.001).
  • [ISSN] 1812-9269
  • [Journal-full-title] Experimental oncology
  • [ISO-abbreviation] Exp. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ukraine
  • [Chemical-registry-number] 0 / Autovaccines; 0 / Biomarkers, Tumor; 0 / CTNNB1 protein, human; 0 / Neoplasm Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; 0 / beta Catenin; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / ERBB2 protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2
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49. Rivera M, Ricarte-Filho J, Patel S, Tuttle M, Shaha A, Shah JP, Fagin JA, Ghossein RA: Encapsulated thyroid tumors of follicular cell origin with high grade features (high mitotic rate/tumor necrosis): a clinicopathologic and molecular study. Hum Pathol; 2010 Feb;41(2):172-80
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  • In current classification schemes, they are called atypical adenomas or follicular, papillary, or poorly differentiated carcinoma.
  • [MeSH-major] Adenocarcinoma, Follicular / genetics. Adenocarcinoma, Follicular / pathology. Thyroid Neoplasms / genetics. Thyroid Neoplasms / pathology


50. Pentheroudakis G, Lazaridis G, Pavlidis N: Axillary nodal metastases from carcinoma of unknown primary (CUPAx): a systematic review of published evidence. Breast Cancer Res Treat; 2010 Jan;119(1):1-11
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  • Axillary lymph node metastases from adeno carcinoma or poorly differentiated carcinoma of unknown primary (CUPAx) represent a rare clinical entity without consensus on its biology, management and outcome.
  • CUPAx affected women at a mean age of 52 years, 66% of whom post-menopausal harbouring low-volume (N1, 48%) or high-volume (52%) nodal disease from ductal adenocarcinoma (83%).
  • [MeSH-major] Adenocarcinoma / pathology. Axilla / pathology. Carcinoma / pathology. Lymphatic Metastasis / diagnosis. Neoplasms, Unknown Primary / pathology

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  • (PMID = 19771506.001).
  • [ISSN] 1573-7217
  • [Journal-full-title] Breast cancer research and treatment
  • [ISO-abbreviation] Breast Cancer Res. Treat.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] EC 2.7.10.1 / ERBB2 protein, human; EC 2.7.10.1 / Receptor, ErbB-2
  • [Number-of-references] 46
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51. Yoshida H, Mamada Y, Taniai N, Mizuguchi Y, Nakamura Y, Nomura T, Yoshioka M, Kiyama T, Kato S, Nishi K, Naito Z, Akimaru K, Tajiri T: Ruptured metastatic liver tumor from an alpha-fetoprotein-producing gastric cancer. J Nippon Med Sch; 2005 Aug;72(4):236-41
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  • Microscopically, the tumor was a poorly differentiated adenocarcinoma invading no deeper than the subserosa, with positive staining for AFP and positive staining for Ki67 in approximately 80% of the tumor cells.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Liver Neoplasms / secondary. Stomach Neoplasms / metabolism. Stomach Neoplasms / pathology. alpha-Fetoproteins / analysis


52. Cindolo L, Franco R, Cantile M, Schiavo G, Liguori G, Chiodini P, Salzano L, Autorino R, Di Blasi A, Falsaperla M, Feudale E, Botti G, Gallo A, Cillo C: NeuroD1 expression in human prostate cancer: can it contribute to neuroendocrine differentiation comprehension? Eur Urol; 2007 Nov;52(5):1365-73
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  • CONCLUSIONS: Expression of NeuroD1 versus chromogranin-A is more frequent in pCA, and correlates to increased indicators of malignancy in moderately to poorly differentiated pCA, and could be involved in the pathophysiology of the neuroendocrine differentiation of pCA.
  • [MeSH-major] Adenocarcinoma / genetics. Basic Helix-Loop-Helix Transcription Factors / genetics. Cell Differentiation / genetics. Gene Expression Regulation, Neoplastic. Prostatic Neoplasms / genetics. RNA, Neoplasm / genetics

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  • [CommentIn] Eur Urol. 2007 Nov;52(5):1373 [17985422.001]
  • (PMID = 17126478.001).
  • [ISSN] 0302-2838
  • [Journal-full-title] European urology
  • [ISO-abbreviation] Eur. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Biomarkers, Tumor; 0 / Chromogranin A; 0 / NEUROD1 protein, human; 0 / RNA, Neoplasm
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53. Väisänen MR, Väisänen T, Jukkola-Vuorinen A, Vuopala KS, Desmond R, Selander KS, Vaarala MH: Expression of toll-like receptor-9 is increased in poorly differentiated prostate tumors. Prostate; 2010 Jun 1;70(8):817-24
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  • [Title] Expression of toll-like receptor-9 is increased in poorly differentiated prostate tumors.
  • Prostate adenocarcinoma cells were all positive for TLR9, AR, and ERbeta but negative for ERalpha expression.
  • CONCLUSIONS: Expression of TLR9 is increased in prostate cancer specimens, especially in the most poorly differentiated forms.
  • [MeSH-major] Adenocarcinoma / metabolism. Prostate / metabolism. Prostatic Hyperplasia / metabolism. Prostatic Neoplasms / metabolism. Toll-Like Receptor 9 / metabolism


54. Shiozaki A, Miyazaki H, Niisato N, Nakahari T, Iwasaki Y, Itoi H, Ueda Y, Yamagishi H, Marunaka Y: Furosemide, a blocker of Na+/K+/2Cl- cotransporter, diminishes proliferation of poorly differentiated human gastric cancer cells by affecting G0/G1 state. J Physiol Sci; 2006 Dec;56(6):401-6
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  • [Title] Furosemide, a blocker of Na+/K+/2Cl- cotransporter, diminishes proliferation of poorly differentiated human gastric cancer cells by affecting G0/G1 state.
  • We found that poorly differentiated gastric adenocarcinoma cells (MKN45) expressed the mRNA of NKCC1 three times higher than moderately differentiated ones (MKN28) and that the NKCC in MKN45 showed higher activity than that in MKN28.
  • Based on these observations, we indicate that furosemide diminishes cell growth by delaying the G(1)-S phase progression in poorly differentiated gastric adenocarcinoma cells, which show high expression and activity of NKCC, but not in moderately differentiated gastric adenocarcinoma cells with low expression and NKCC activity.
  • [MeSH-major] Adenocarcinoma / pathology. Cell Proliferation / drug effects. Furosemide / pharmacology. Sodium Potassium Chloride Symporter Inhibitors / pharmacology. Stomach Neoplasms / pathology

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  • (PMID = 17052386.001).
  • [ISSN] 1880-6546
  • [Journal-full-title] The journal of physiological sciences : JPS
  • [ISO-abbreviation] J Physiol Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Sodium Potassium Chloride Symporter Inhibitors; 0 / Sodium-Potassium-Chloride Symporters; 7LXU5N7ZO5 / Furosemide
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55. Ikeda T, Nakayama Y, Hamada Y, Takeshita M, Iwasaki H, Maeshiro K, Yamashita Y, Kuroki M, Ikeda S: FU-MK-1 expression in human gallbladder carcinoma: an antigenic prediction marker for a better postsurgical prognosis. Am J Clin Pathol; 2009 Jul;132(1):111-7
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  • All 21 papillary and 12 of 13 well-differentiated tubular adenocarcinomas but only 1 of 8 poorly differentiated adenocarcinomas were positive for FU-MK-1.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma, Papillary / pathology. Antigens, Neoplasm / metabolism. Cell Adhesion Molecules / metabolism. Cholecystectomy. Gallbladder Neoplasms / pathology

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  • (PMID = 19864241.001).
  • [ISSN] 1943-7722
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Cell Adhesion Molecules; 0 / EPCAM protein, human
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56. Bergmann F, Ceyhan GO, Rieker RJ, Esposito I, Fischer L, Herpel E, Friess H, Schirmacher P, Kern MA: Fundamental differences in the neural invasion behavior of pancreatic endocrine tumors: relevance for local recurrence rates? Hum Pathol; 2009 Jan;40(1):50-7
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  • In the present study, a total of 48 pancreatic endocrine tumors were analyzed including 10 well-differentiated endocrine tumors of uncertain behavior, 33 well-differentiated endocrine carcinomas, and 5 poorly differentiated endocrine carcinomas.
  • Analogous to pancreatic ductal adenocarcinoma, the expression of epidermal growth factor receptor and nerve growth factor, which were expressed in 50% and 100% of the tumors, respectively, seemed to be associated with the frequency of neural invasion.
  • However, in contrast to pancreatic ductal adenocarcinoma, neural invasion in pancreatic endocrine tumors was only detected within the tumor boundaries and did not reach beyond the tumor invasion front.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Pancreatic Ductal / pathology. Neoplasm Recurrence, Local / pathology. Nervous System / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 18789481.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9061-61-4 / Nerve Growth Factor; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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57. Ohara T, Kanoh Y, Tani N, Ohdaira H, Suzuki Y, Kameyama J, Yoshino K, Kitajima M: Single nucleotide polymorphism typing of the human toll-like receptor 4 gene at the 2-kb upstream region of the 5' untranslated region: New enclosure strategy for the risk grouping of poorly-differentiated gastric adenocarcinoma patients. Mol Med Rep; 2009 Jan-Feb;2(1):17-21
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  • [Title] Single nucleotide polymorphism typing of the human toll-like receptor 4 gene at the 2-kb upstream region of the 5' untranslated region: New enclosure strategy for the risk grouping of poorly-differentiated gastric adenocarcinoma patients.
  • To date, no enclosure method for risk grouping patients with poorly-differentiated gastric adenocarcinoma has been identified.
  • We examined the relationship between mutations in toll-like receptor 4 (TLR4) and patients with poorly-differentiated gastric adenocarcinoma.
  • Genomic DNA was extracted from the peripheral blood of 38 patients, 20 with well-differentiated and 18 with poorly-differentiated gastric cancer, from 25 patients with colorectal cancer and from 10 healthy volunteers.
  • The results revealed the presence of single nucleotide polymorphisms (SNPs) only among patients with poorly-differentiated gastric adenocarcinoma.
  • SNPs were found at 3 sites: -2081, -2026 and -1601 in 12, 15 and 15 of the 18 cases of poorly-differentiated gastric adenocarcinoma, respectively.
  • Polymorphism analysis of the upstream region of the 5' UTR of TLR4 may be a useful new enclosure strategy for the risk grouping of poorly-differentiated gastric adenocarcinoma patients.

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  • (PMID = 21475784.001).
  • [ISSN] 1791-2997
  • [Journal-full-title] Molecular medicine reports
  • [ISO-abbreviation] Mol Med Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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58. Asakura H, Takashima H, Mitani M, Haba R, Seo R, Yokoe K, Toyama Y, Ohkawa M: Unknown primary carcinoma, diagnosed as inflammatory breast cancer,and successfully treated with trastuzumab and vinorelbine. Int J Clin Oncol; 2005 Aug;10(4):285-8
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  • Axillary lymph node dissection was performed, and the lesion was diagnosed as a poorly differentiated adenocarcinoma.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / drug therapy. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Humanized. Axilla. Female. Fluorodeoxyglucose F18. Humans. Lymphatic Diseases. Lymphatic Metastasis / pathology. Middle Aged. Neoplasm Staging. Radiopharmaceuticals. Receptor, ErbB-2 / metabolism. Tomography, Emission-Computed. Trastuzumab. Treatment Outcome. Vinblastine / administration & dosage. Vinblastine / analogs & derivatives


59. Brecelj E, Frković Grazio S, Auersperg M, Bracko M: Prognostic value of E-cadherin expression in thyroid follicular carcinoma. Eur J Surg Oncol; 2005 Jun;31(5):544-8
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  • In univariate analysis, DMFS was significantly worse in male patients (P<0.03), widely invasive tumours (P=0.0002), moderately/poorly differentiated tumours (P<0.05) and tumours showing reduced E-cadherin expression (P=0.0001).
  • [MeSH-major] Adenocarcinoma, Follicular / metabolism. Cadherins / metabolism. Thyroid Neoplasms / metabolism

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  • (PMID = 15922891.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins
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60. Marcu M, Radu E, Sajin M: Neuroendocrine differentiation in prostate adenocarcinoma biopsies and its correlation to histological grading. Curr Health Sci J; 2010 Jan;36(1):37-42
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  • [Title] Neuroendocrine differentiation in prostate adenocarcinoma biopsies and its correlation to histological grading.
  • Prostate adenocarcinoma is frequently diagnosed on needle biopsies in early, organ-confined stages.
  • Multinomial regression analysis showed that high Ki indices, serum PSA values and NSE scores are predictive for moderately and poorly differentiated prostatic adenocarcinoma.

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  • (PMID = 24778825.001).
  • [ISSN] 2067-0656
  • [Journal-full-title] Current health sciences journal
  • [ISO-abbreviation] Curr Health Sci J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Other-IDs] NLM/ PMC3945267
  • [Keywords] NOTNLM ; Neuroendocrine differentiation / Prostate adenocarcinoma
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61. Szynglarewicz B, Matkowski R, Halon A, Lacko A, Stepien M, Forgacz J, Pudelko M, Kornafel J: Association between histological type of tumour growth and patient survival in t2-t3 lymph node-negative rectal cancer treated with sphincter-preserving total mesorectal excision. Pathol Oncol Res; 2010 Jun;16(2):201-6
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  • Survival was decreased for males, older patients (>60 years) with extraperitoneal, poorly differentiated cancers, tumours with mucinous histology and with the absence of lymphocytic infiltration but with the lack of statistical importance.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / pathology. Rectal Neoplasms / mortality. Rectal Neoplasms / pathology

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  • (PMID = 19757194.001).
  • [ISSN] 1532-2807
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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62. Kitajima Y, Yakabe T, Ohtsuka T, Tanaka M, Sato S, Nakafusa Y, Miyazaki K: [Complete response obtained with first-line therapy as S-1, followed by second-line 5'-DFUR plus paclitaxel therapy in a patient with multiple liver and lymph node metastases from gastric cancer]. Gan To Kagaku Ryoho; 2009 May;36(5):851-4
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  • The histological diagnosis was poorly-differentiated adenocarcinoma, T2(MP), pN2, sH0, sP0, CY0; fStage III A.

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  • (PMID = 19461193.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Drug Combinations; 039LU44I5M / Floxuridine; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; P88XT4IS4D / Paclitaxel; V1JK16Y2JP / doxifluridine
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63. Zhang Y, Le H, Chen Z, Wang C, Zhang B: [Study on relationship between blood supply from pulmonary artery and pathological characteristics of patients with primary bronchogenic carcinoma]. Zhongguo Fei Ai Za Zhi; 2006;9(4):333-6
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  • The development rate of squamous cell carcinoma (91.30%) was remarkably higher than that of adenocarcinoma (61.11%) (P < 0.05).
  • The development rate of poorly differentiated lung cancer (95.00%) was remarkably higher than that of well and moderately differentiated lung cancer (65.22%) (P < 0.05).

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  • (PMID = 21176449.001).
  • [ISSN] 1009-3419
  • [Journal-full-title] Zhongguo fei ai za zhi = Chinese journal of lung cancer
  • [ISO-abbreviation] Zhongguo Fei Ai Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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64. Mróz A, Kiedrowski M, Malinowska M, Sopyło R: Collision tumour of the stomach--adenocarcinoma and neuroendocrine carcinoma: case report and review of the literature. Pol J Pathol; 2009;60(2):94-7
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  • [Title] Collision tumour of the stomach--adenocarcinoma and neuroendocrine carcinoma: case report and review of the literature.
  • We report a rare case of gastric collision tumour composed of poorly differentiated adenocarcinoma and neuroendocrine carcinoma in a 56-year-old Caucasian male.
  • The adenocarcinoma component constituted 20% of the lesion and was in a more advanced stage than the neuroendocrine component.
  • Additionally, the adenocarcinoma was the only one to metastasize to regional lymph nodes and the liver.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Neuroendocrine / pathology. Neoplasms, Multiple Primary / pathology. Stomach Neoplasms / pathology

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  • (PMID = 19886184.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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65. Iwakiri S, Sonobe M, Nagai S, Hirata T, Wada H, Miyahara R: Expression status of folate receptor alpha is significantly correlated with prognosis in non-small-cell lung cancers. Ann Surg Oncol; 2008 Mar;15(3):889-99
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  • RESULTS: In adenocarcinoma, the FOLR1 gene expression was downregulated in smokers and male patients (P = 0.006 and P < 0.001, respectively).
  • In addition, FOLR1 expression values in patients with well-differentiated, early p-stage, pT1, pN0, EGFR mutant, and p53 wild-type cancers were significantly higher than those for poorly differentiated, advanced p-stage, pT2-4, pN1-3, EGFR wild-type, and p53 mutant (P < 0.001, P < 0.001, P < 0.001, P = 0.002, P < 0.001 and P = 0.023, respectively).

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  • (PMID = 18181001.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / FOLR1 protein, human; 0 / Folate Receptor 1; 0 / Folate Receptors, GPI-Anchored; 0 / Receptors, Cell Surface
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66. Hirano H, Yoshida T, Yoshimura H, Fukuoka M, Ohkubo E, Tachibana S, Saito H, Nakasho K, Nishigami T: Poorly differentiated adenocarcinoma with signet-ring cell carcinoma in a hyperplastic polyp of the stomach: report of a case. Surg Today; 2007;37(10):901-4
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  • [Title] Poorly differentiated adenocarcinoma with signet-ring cell carcinoma in a hyperplastic polyp of the stomach: report of a case.
  • Histologically, the large polyp consisted mainly of hyperplastic foveolar epithelium, while the presence of variously colored lobules demonstrated a poorly differentiated adenocarcinoma mixed with signet-ring cell carcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Stomach Neoplasms / diagnosis


67. Yamanaka T, Okabe K, Sugiyama S, Sano O, Wada A, Beppu T, Baba H: [An elderly patient with advanced gastric cancer maintaining complete response for over 3 years by oral administration of UFT following short span of S-1]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2424-6
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  • Endoscopy revealed a type 3 advanced gastric cancer, and the biopsy specimen was defined histologically as poorly-differentiated adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antimetabolites, Antineoplastic / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Oxonic Acid / administration & dosage. Stomach Neoplasms / drug therapy. Tegafur / administration & dosage

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  • (PMID = 21224594.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; 5VT6420TIG / Oxonic Acid; 1-UFT protocol
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68. Agaram NP, Shia J, Tang LH, Klimstra DS: DNA mismatch repair deficiency in ampullary carcinoma: a morphologic and immunohistochemical study of 54 cases. Am J Clin Pathol; 2010 May;133(5):772-80
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  • All tumors were moderately (n = 49) or poorly (n = 5) differentiated, with 7 mucinous and 1 signet-ring cell type.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. DNA Mismatch Repair / genetics. Nuclear Proteins

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  • (PMID = 20395525.001).
  • [ISSN] 1943-7722
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein; 0 / MLH1 protein, human; 0 / Nuclear Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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69. Ludovini V, Pistola L, Gregorc V, Floriani I, Rulli E, Di Carlo L, Semeraro A, Daddi G, Darwish S, Stocchi L, Tofanetti FR, Bellezza G, Sidoni A, Tognellini R, Crinò L, Tonato M: Biological markers and DNA flow cytometric analysis in radically resected patients with non-small cell lung cancer. A study of the Perugia Multidisciplinary Team for Thoracic Tumors. Tumori; 2008 May-Jun;94(3):398-405
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  • Median age was 66 years (range, 31-84 years), male/female ratio 117/19, ECOG performance status 0/1 127/4, stage I/II/III 76/25/35, squamous/adenocarcinoma/large-cell/mixed histology 62/49/17/8, smokers yes/no 121/11.
  • Statistically significant associations between high Ki67 and poorly differentiated tumors (P = 0.016) and a smoking history (P = 0.053); p53 positivity and high Ki67 (P = 0.002); HER-2 positivity and adenocarcinoma subtype (P = 0.015) and presence of lymph node involvement (P = 0.006); and Bcl-2 positivity and squamous cell carcinoma subtype (P = 0.058) were observed.
  • [MeSH-minor] Adenocarcinoma / chemistry. Adenocarcinoma / genetics. Adult. Aged. Aged, 80 and over. Carcinoma, Large Cell / chemistry. Carcinoma, Large Cell / genetics. Carcinoma, Squamous Cell / chemistry. Carcinoma, Squamous Cell / genetics. Female. Humans. Immunohistochemistry. Italy. Kaplan-Meier Estimate. Ki-67 Antigen / analysis. Male. Middle Aged. Neoplasm Staging. Ploidies. Predictive Value of Tests. Prognosis. Proto-Oncogene Proteins c-bcl-2 / analysis. Receptor, ErbB-2 / analysis. Tumor Suppressor Protein p53 / analysis


70. Sheridan T, Herawi M, Epstein JI, Illei PB: The role of P501S and PSA in the diagnosis of metastatic adenocarcinoma of the prostate. Am J Surg Pathol; 2007 Sep;31(9):1351-5
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  • [Title] The role of P501S and PSA in the diagnosis of metastatic adenocarcinoma of the prostate.
  • BACKGROUND: Adenocarcinoma of the prostate can present as metastatic carcinoma with no known primary.
  • The tissue microarray contains 78 cases of metastatic prostatic adenocarcinoma, 20 cases of primary prostatic adenocarcinoma, and 20 cases of benign prostate tissue from the peripheral zone as well as samples of benign brain, pancreas, kidney, thyroid, testis, skeletal muscle, and fibroconnective tissue.
  • The P501S stain had perinuclear cytoplasmic (Golgi) distribution even in poorly differentiated tumors and metastases.
  • A small subset of metastatic prostatic adenocarcinoma shows significant differences in staining intensity and extent for PSA and P501S and, therefore, combined use of these markers may result in increased sensitivity for detecting prostatic origin.
  • [MeSH-major] Adenocarcinoma / diagnosis. Membrane Proteins / analysis. Neoplasms, Unknown Primary / diagnosis. Prostate-Specific Antigen / analysis. Prostatic Neoplasms / diagnosis

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  • (PMID = 17721190.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P50 CA58236
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / prostein; EC 3.4.21.77 / Prostate-Specific Antigen
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71. Zhao Y, Deng X, Wang Q: [Expression and clinical significance of apoptosis associated genes Livin and Smac/DIABLO in human gastric carcinomas]. Ai Zheng; 2009 Jun;28(6):593-601
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  • The expression of Livin was higher in poorly differentiated gastric carcinomas and carcinomas with lymph node metastases than in highly differentiated gastric carcinomas and carcinomas without lymph node metastases. (Chi2=9.60, P<0.01; Chi2=5.51, P<0.05).
  • The expression of Smac/DIABLO mRNA was not correlated to clinicopathological characters of gastric adenocarcinoma.
  • [MeSH-major] Adaptor Proteins, Signal Transducing / metabolism. Adenocarcinoma / metabolism. Inhibitor of Apoptosis Proteins / metabolism. Intracellular Signaling Peptides and Proteins / metabolism. Mitochondrial Proteins / metabolism. Neoplasm Proteins / metabolism. Stomach Neoplasms / metabolism

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  • (PMID = 19635196.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / BIRC7 protein, human; 0 / DIABLO protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / Mitochondrial Proteins; 0 / Neoplasm Proteins; 0 / RNA, Messenger
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72. Cho JY, Shim EJ, Kim IS, Nam EM, Choi MY, Lee KE, Mun YC, Seoung CM, Lee SN, Song DE, Han WS: Cancer of unknown primary finally revealed to be a metastatic prostate cancer: a case report. Cancer Res Treat; 2009 Mar;41(1):45-9
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  • Here, we report a patient who presented with a periureteral tumor of unknown primary site that was confirmed as prostate adenocarcinoma after three years with using specific immunohistochemical examination.
  • After an exploratory mass excision and left nephrectomy, the pelvic mass was diagnosed as poorly differentiated carcinoma without specific positive immunohistochemical markers.
  • We suggest the usefulness of newly developed immunohistochemical markers such as P504S to determine the specific primary site of metastatic poorly differentiated adenocarcinoma in men.

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  • (PMID = 19688071.001).
  • [ISSN] 1598-2998
  • [Journal-full-title] Cancer research and treatment : official journal of Korean Cancer Association
  • [ISO-abbreviation] Cancer Res Treat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2699091
  • [Keywords] NOTNLM ; Cancer of unknown primary / Metastatic prostate cancer / P504S
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73. Rask K, Zhu Y, Wang W, Hedin L, Sundfeldt K: Ovarian epithelial cancer: a role for PGE2-synthesis and signalling in malignant transformation and progression. Mol Cancer; 2006;5:62
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  • Increased expressions were also observed for COX-1, mPGES-1 and EP-1 which all were significantly (p < 0.05) augmented in less differentiated AC (grades: moderately-, poorly- and undifferentiated).
  • IHC revealed staining of the tumour cells, but also increase of COX-1, COX-2, mPGES-1 and EP1-2 in the stromal compartment of AC (grades: moderately-, poorly- and undifferentiated).
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Cyclooxygenase 1 / metabolism. Cyclooxygenase 2 / metabolism. Densitometry. Disease Progression. Epithelial Cells / pathology. Female. Humans. Immunoblotting. Immunohistochemistry. Intramolecular Oxidoreductases / metabolism. Neoplasm Staging. Ovary / metabolism. Receptors, Prostaglandin E / metabolism

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  • (PMID = 17107625.001).
  • [ISSN] 1476-4598
  • [Journal-full-title] Molecular cancer
  • [ISO-abbreviation] Mol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, Prostaglandin E; EC 1.14.99.1 / Cyclooxygenase 1; EC 1.14.99.1 / Cyclooxygenase 2; EC 5.3.- / Intramolecular Oxidoreductases; EC 5.3.99.3 / prostaglandin-E synthase; K7Q1JQR04M / Dinoprostone
  • [Other-IDs] NLM/ PMC1657027
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74. Wang TB, Deng MH, Qiu WS, Dong WG: Association of serum vascular endothelial growth factor-C and lymphatic vessel density with lymph node metastasis and prognosis of patients with gastric cancer. World J Gastroenterol; 2007 Mar 28;13(12):1794-7; discussion 1797-8
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  • Both SVEGF-C and LVD were significantly higher in poorly differentiated adenocarcinomas, T3 and T4, LNM, distant metastasis, and pTNM groups III and IV (P = 0.000).
  • [MeSH-major] Adenocarcinoma / blood. Adenocarcinoma / secondary. Lymphatic Vessels / pathology. Stomach Neoplasms / blood. Stomach Neoplasms / pathology. Vascular Endothelial Growth Factor C / blood

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  • (PMID = 17465468.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Vascular Endothelial Growth Factor C
  • [Other-IDs] NLM/ PMC4149954
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75. Lam AK, Ong K, Ho YH: Aurora kinase expression in colorectal adenocarcinoma: correlations with clinicopathological features, p16 expression, and telomerase activity. Hum Pathol; 2008 Apr;39(4):599-604
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  • [Title] Aurora kinase expression in colorectal adenocarcinoma: correlations with clinicopathological features, p16 expression, and telomerase activity.
  • The aim of the present study was to investigate the clinicopathological roles of aurora kinase protein expression in a large cohort of patients with colorectal adenocarcinoma with tight methodology and close follow-up.
  • The protein was more frequently detected in patients with well or moderately differentiated colorectal carcinomas than in poorly differentiated colorectal adenocarcinomas (52% versus 31%, P = .004).
  • [MeSH-major] Adenocarcinoma / enzymology. Adenocarcinoma / pathology. Colorectal Neoplasms / enzymology. Colorectal Neoplasms / pathology. Protein-Serine-Threonine Kinases / metabolism

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  • (PMID = 18284933.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; EC 2.7.11.1 / Aurora Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.7.49 / TERT protein, human; EC 2.7.7.49 / Telomerase
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76. Natalie AA, Nichols L, Bump GM: Platypnea-orthodeoxia, an uncommon presentation of patent foramen ovale. Am J Med Sci; 2010 Jan;339(1):78-80
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  • On postmortem examination, the patient had an underlying poorly differentiated lung adenocarcinoma.

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  • (PMID = 19926970.001).
  • [ISSN] 1538-2990
  • [Journal-full-title] The American journal of the medical sciences
  • [ISO-abbreviation] Am. J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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77. Sarli L, Bottarelli L, Azzoni C, Campanini N, Di Cola G, Barilli AL, Marchesi F, Mazzeo A, Salvemini C, Morari S, Di Mauro D, Donadei E, Necchi F, Roncoroni L, Bordi C: Loss of p27 expression and microsatellite instability in sporadic colorectal cancer. Surg Oncol; 2006 Aug;15(2):97-106
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  • This altered expression was significantly higher in proximal cancers (P<0.05), mucinous tumours (P<0.001), poorly differentiated histology (P<0.01), cancers with MSI (P<0.05), tumours with altered expression of Mlh1 (P<0.01), of Msh2 (P<0.05), and of Fhit (P<0.01).
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / metabolism. Adult. Aged. Aged, 80 and over. Female. Humans. Immunohistochemistry. Loss of Heterozygosity. Male. Microsatellite Repeats. Middle Aged. Polymerase Chain Reaction. Treatment Outcome

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  • (PMID = 17123889.001).
  • [ISSN] 0960-7404
  • [Journal-full-title] Surgical oncology
  • [ISO-abbreviation] Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Proliferating Cell Nuclear Antigen; 0 / p27 antigen
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78. Arai T, Takubo K: Clinicopathological and molecular characteristics of gastric and colorectal carcinomas in the elderly. Pathol Int; 2007 Jun;57(6):303-14
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  • In the elderly there are peculiar types of carcinoma such as medullary-type poorly differentiated colorectal adenocarcinoma and solid-type poorly differentiated gastric adenocarcinoma, both of which occur in older women.

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  • (PMID = 17539960.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Australia
  • [Number-of-references] 123
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79. Jo DH, Cheung DY, Kim HK, Son DK, Chung JS, Kim JI, Park SH, Han JY, Kim JK, Chung KW: [Small bowel metastasis from breast cancer: a case report]. Korean J Gastroenterol; 2005 Aug;46(2):137-41
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  • The histology of the tissue taken from small bowel mass was adenocarcinoma, poorly differentiated.
  • [MeSH-major] Adenocarcinoma / secondary. Breast Neoplasms / pathology. Intestinal Neoplasms / secondary

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  • (PMID = 16118525.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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80. Park JM, Chi KC: Unresectable gastric cancer with gastric outlet obstruction and distant metastasis responding to intraperitoneal and folfox chemotherapy after palliative laparoscopic gastrojejunostomy: report of a case. World J Surg Oncol; 2010;8:109
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  • CASE PRESENTATION: We report a case of 55-year-old man who was diagnosed with a poorly differentiated adenocarcinoma in the pre-pyloric antrum with GOO by gastroscopy.
  • [MeSH-major] Adenocarcinoma / therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Gastric Bypass. Gastric Outlet Obstruction. Laparoscopy. Stomach Neoplasms / therapy

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  • (PMID = 21167074.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
  • [Other-IDs] NLM/ PMC3014937
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81. Chintamani, Singhal V, Bansal A, Bhatnagar D, Saxena S: Isolated colostomy site recurrence in rectal cancer-two cases with review of literature. World J Surg Oncol; 2007;5:52
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  • CASE PRESENTATION: First case was a 30-year-old male that had reported with large bowel obstruction due to an obstructing ulcero-proliferative growth (poorly differentiated adenocarcinoma) at the colostomy site after abdomino-perineal resection, performed for low rectal cancer six years previously.
  • Second case was a 47-year-old male that presented with acute large bowel obstruction due to an annular growth (well differentiated adenocarcinoma) in the upper rectum.
  • Five years following closure of colostomy, he presented with two parietal masses at the previous colostomy site scar, which, on fine needle aspiration cytology were found to be well-differentiated adenocarcinomas of colorectal type.
  • [MeSH-major] Adenocarcinoma / pathology. Colostomy / adverse effects. Neoplasms, Second Primary / pathology. Rectal Neoplasms / surgery

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  • (PMID = 17567928.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 10
  • [Other-IDs] NLM/ PMC1876234
  • [General-notes] NLM/ Original DateCompleted: 20070730
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82. Ang TL, Ng TM, Fock KM, Teo EK: Accuracy of endoscopic ultrasound staging of gastric cancer in routine clinical practice in Singapore. Chin J Dig Dis; 2006;7(4):191-6
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  • The majority was poorly differentiated (57.1%); 26% were moderately differentiated and 16.9% were well differentiated adenocarcinoma.

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  • (PMID = 17054580.001).
  • [ISSN] 1443-9611
  • [Journal-full-title] Chinese journal of digestive diseases
  • [ISO-abbreviation] Chin J Dig Dis
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Australia
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83. Rong BG, Chen WL, Ding YP, Xie G, Chen Y, Wang TD: [Surgical approaches to the skull base neoplasms]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2005 Apr;40(4):291-4
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  • For 50 patients with malignant tumor including 3 cases of well-differentiated squamous cell carcinoma, 17 cases of moderately differentiated squamous cell carcinoma, 11 cases of poorly differentiated squamous cell carcinoma, 1 case of undifferentiated carcinoma, 2 cases of chondrosarcoma, 5 cases of canceration of papilloma, 2 cases of adenocarcinoma, 1 case of esthesioneuroblastoma, 2 cases of malignant fibrohistiocytoma, 1 case of fibrosarcoma, 2 cases of malignant mixed tumour, 3 cases of sarcoma survival rates of 3 and 5 years were 59.2% (29/49), 38.5% (10/26) respectively.

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  • (PMID = 16008265.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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84. Tomizawa M, Tsuyuguchi T, Sakai Y, Sugiyama H, Miyakawa K, Ishihara T, Yokosuka O: [Case of intrahepatic cholangiocarcinoma drained through a fistula of the duodenal bulb]. Nihon Shokakibyo Gakkai Zasshi; 2010 Dec;107(12):1970-7
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  • Since she complained epigastralgia, upper gastrointestinal endoscopy was performed, showing an ulcer in the duodenal bulb, with poorly-differentiated adenocarcinoma seen on a biopsy specimen from the edge of the ulcer.
  • After admission, poorly-differentiated adenocarcinoma cells were also obtained with ultrasound guided aspiration cytology of the liver tumor.


85. Agrawal AR, Nair N: Unusual metastasis of poorly differentiated thyroid carcinoma to the masticator space. Clin Nucl Med; 2007 Jul;32(7):516-8
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  • [Title] Unusual metastasis of poorly differentiated thyroid carcinoma to the masticator space.
  • We report an unusual case of metastasis to the masticator space from a poorly differentiated carcinoma of the thyroid.
  • [MeSH-major] Adenocarcinoma, Papillary / diagnosis. Adenocarcinoma, Papillary / secondary. Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / secondary. Stomatognathic Diseases / diagnosis. Thyroid Neoplasms / diagnosis

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  • (PMID = 17581333.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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86. Cho YM, Choi J, Lee OJ, Lee HI, Han DJ, Ro JY: SMARCB1/INI1 missense mutation in mucinous carcinoma with rhabdoid features. Pathol Int; 2006 Nov;56(11):702-6
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  • Microscopically, the tumor had a biphasic growth pattern: a mucinous carcinoma component and a poorly differentiated carcinoma component with rhabdoid features showing loosely cohesive cells with abundant eosinophilic cytoplasm, displaced nuclei, and prominent nucleoli.
  • [MeSH-major] Adenocarcinoma, Mucinous / genetics. Chromosomal Proteins, Non-Histone / genetics. DNA-Binding Proteins / genetics. Mutation, Missense. Pancreatic Neoplasms / genetics. Rhabdoid Tumor / genetics. Transcription Factors / genetics

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  • (PMID = 17040295.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors; 0 / Vimentin; 68238-35-7 / Keratins
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87. Lauenstein TC, Martin DR, Sarmiento JM, Kalb B, Moreira R, Carew J, Salman K, Adsay V: Pancreatic adenocarcinoma tumor grade determination using contrast-enhanced magnetic resonance imaging. Pancreas; 2010 Jan;39(1):71-5
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  • [Title] Pancreatic adenocarcinoma tumor grade determination using contrast-enhanced magnetic resonance imaging.
  • OBJECTIVES: To determine whether the degree of enhancement of pancreatic adenocarcinoma visualized on arterial phase gadolinium-enhanced magnetic resonance imaging (MRI) correlates with the histopathological tumor grade.
  • METHODS: Thirty-nine patients with pancreatic adenocarcinoma had MRI within 14 days before tumor resection.
  • RESULTS: Based on histological grading, there were 12 poorly differentiated, 2 poorly to moderately differentiated, 22 moderately differentiated, and 3 well-differentiated adenocarcinomas.
  • CONCLUSIONS: Pancreatic adenocarcinoma arterial phase enhancement correlates with the histological grade of differentiation.
  • [MeSH-major] Adenocarcinoma / pathology. Magnetic Resonance Imaging / methods. Pancreatic Neoplasms / pathology

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  • (PMID = 19745775.001).
  • [ISSN] 1536-4828
  • [Journal-full-title] Pancreas
  • [ISO-abbreviation] Pancreas
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; AU0V1LM3JT / Gadolinium
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88. De Miglio MR, Virdis P, Calvisi DF, Mele D, Muroni MR, Frau M, Pinna F, Tomasi ML, Simile MM, Pascale RM, Feo F: Identification and chromosome mapping of loci predisposing to colorectal cancer that control Wnt/beta-catenin pathway and progression of early lesions in the rat. Carcinogenesis; 2007 Nov;28(11):2367-74
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  • Here, we performed genome-wide scanning of male (ACI/SegHsd x Wistar-Furth)F2 (AWF2) rats to map susceptibility genes influencing the evolution of early colorectal lesions to adenocarcinoma following 1,2-dimethylhydrazine administration.
  • Phenotypic analysis revealed higher incidence/multiplicity and lower size of adenomas in ACI/SegHsd (ACI) and (ACI/SegHsd x Wistar-Furth)F1 (AWF1) than Wistar-Furth (WF) rats and higher incidence/multiplicity of poorly differentiated adenocarcinomas in WF than ACI rats, with intermediate values in AWF1 rats.
  • Seven other loci on chromosomes 5, 6, 15, 17, 18 and 20 were in suggestive linkage with adenoma/adenocarcinoma multiplicity/surface area.

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  • (PMID = 17510081.001).
  • [ISSN] 1460-2180
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] eng
  • [Grant] United States / NIAAA NIH HHS / AA / F32 AA020150
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Wnt Proteins; 0 / beta Catenin
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89. Chinen K, Tokuda Y, Fujiwara M, Fujioka Y: Pulmonary tumor thrombotic microangiopathy in patients with gastric carcinoma: an analysis of 6 autopsy cases and review of the literature. Pathol Res Pract; 2010 Oct 15;206(10):682-9
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  • All PTTM cases were associated with advanced GC, with a histology of adenocarcinoma of poorly differentiated type (n=4) or signet-ring cell type (n=2).
  • [MeSH-major] Adenocarcinoma / secondary. Carcinoma, Signet Ring Cell / secondary. Lung Neoplasms / secondary. Neoplastic Cells, Circulating / pathology. Stomach Neoplasms / pathology. Thrombotic Microangiopathies / pathology

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  • [Copyright] Copyright © 2010 Elsevier GmbH. All rights reserved.
  • (PMID = 20554399.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; 9035-58-9 / Thromboplastin
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90. Fujishiro R, Naruse Y, Ichinose T, Yamazaki A, Sakamoto R: [A case of gastric cancer with DIC caused by multiple bone metastases treated with TS-1]. Gan To Kagaku Ryoho; 2006 May;33(5):663-5
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  • Histological examination of the endoscopic biopsy revealed poorly-differentiated adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antimetabolites, Antineoplastic / therapeutic use. Bone Neoplasms / drug therapy. Disseminated Intravascular Coagulation / etiology. Oxonic Acid / therapeutic use. Pyridines / therapeutic use. Stomach Neoplasms / drug therapy. Tegafur / therapeutic use

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  • (PMID = 16685168.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 0 / Pyridines; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid
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91. Harper CE, Patel BB, Wang J, Arabshahi A, Eltoum IA, Lamartiniere CA: Resveratrol suppresses prostate cancer progression in transgenic mice. Carcinogenesis; 2007 Sep;28(9):1946-53
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  • In the current study, Transgenic Adenocarcinoma Mouse Prostate males were fed resveratrol (625 mg resveratrol per kg AIN-76A diet) or phytoestrogen-free, control diet (AIN-76A) starting at 5 weeks of age.
  • Resveratrol in the diet significantly reduced the incidence of poorly differentiated prostatic adenocarcinoma by 7.7-fold.

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  • (PMID = 17675339.001).
  • [ISSN] 0143-3334
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 47888; United States / NCI NIH HHS / CA / P30 CA-13148-34
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Stilbenes; Q369O8926L / resveratrol
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92. Nishio S, Tsuda H, Fujiyoshi N, Ota S, Ushijima K, Sasajima Y, Kasamatsu T, Kamura T, Matsubara O: Clinicopathological significance of cervical adenocarcinoma associated with lobular endocervical glandular hyperplasia. Pathol Res Pract; 2009;205(5):331-7
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  • [Title] Clinicopathological significance of cervical adenocarcinoma associated with lobular endocervical glandular hyperplasia.
  • However, LEGH has been associated with obvious cervical adenocarcinoma.
  • The clinicopathological significance of coexistence of LEGH with adenocarcinoma remains unclear.
  • Gastric mucin was positive in all 16 LEGH components, as compared with only 6 of the 95 adenocarcinoma components.
  • Of the 16 adenocarcinomas with LEGH components, 15 were well-differentiated mucinous adenocarcinomas, and one was poorly differentiated adenocarcinoma.
  • Early cervical adenocarcinoma was relatively frequently associated with LEGH components.
  • LEGH may be one of the factors related to the development of cervical adenocarcinoma, but adenocarcinoma with LEGH components does not necessarily develop into a highly aggressive "adenoma malignum. "
  • [MeSH-major] Adenocarcinoma / pathology. Cervix Uteri / pathology. Uterine Cervical Neoplasms / pathology

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  • (PMID = 19167836.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16
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93. Kadokura M, Kamio Y, Kitami A, Nakajima H, Fujisawa H, Kushihashi T, Shiokawa A: Pulmonary adenocarcinoma complicated with pulmonary infarction presented as intrapulmonary metastases: a report of a case. Ann Thorac Cardiovasc Surg; 2006 Jun;12(3):189-93
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  • [Title] Pulmonary adenocarcinoma complicated with pulmonary infarction presented as intrapulmonary metastases: a report of a case.
  • Pulmonary adenocarcinoma complicated with a pulmonary infarction presenting as an intrapulmonary metastasis is relatively rare.
  • Computed tomography (CT) of the chest revealed a hilar mass lesion with parenchymal lesions in the periphery of the right lower lobe, highly suspected to be a pulmonary adenocarcinoma with intrapulmonary metastases.
  • A diagnosis of pulmonary adenocarcinoma was confirmed by a transbronchial brushing examination.
  • Histopathological findings of the resected specimens revealed poorly differentiated adenocarcinoma of the lung with N1 (number 11i and 12 l) disease and multiple pulmonary infarctions with coagulation necrosis and recanalization.
  • [MeSH-major] Adenocarcinoma / complications. Lung Neoplasms / complications. Pulmonary Embolism / complications

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  • (PMID = 16823332.001).
  • [ISSN] 1341-1098
  • [Journal-full-title] Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
  • [ISO-abbreviation] Ann Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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94. Tsuchida K, Morinaga S, Sugano N, Shiozawa M, Akaike M, Sugimasa Y, Takemiya S, Hayashi H, Rino Y, Imada T: [A case of flat elevated type carcinoma in adenoma of the duodenum with gastric cancer]. Gan To Kagaku Ryoho; 2006 Nov;33(12):1878-80
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  • Histologically, the gastric cancer was poorly differentiated adenocarcinoma with submcosal invasion and without lymph node metastasis, and the duodenal tumor was a well differentiated carcinoma in villous adenoma.
  • The duodenal adenocarcinoma was limited to the mucosal layer and the resected margins were free of tumor.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Villous / pathology. Carcinoma / pathology. Duodenal Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Stomach Neoplasms / pathology

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  • (PMID = 17212134.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 4
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95. Li M, Gu Y, Zhang Z, Zhang S, Zhang D, Saleem AF, Zhao X, Sun B: Vasculogenic mimicry: a new prognostic sign of gastric adenocarcinoma. Pathol Oncol Res; 2010 Jun;16(2):259-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vasculogenic mimicry: a new prognostic sign of gastric adenocarcinoma.
  • Till now, there is no report about VM in gastric adenocarcinoma (GAC).
  • VM was observed in 40 of the 173 GAC patients, especially in poorly differentiated GAC (P = 0.014).
  • In conclusion, VM exists in GAC, especially in poorly differentiated GAC.
  • [MeSH-major] Adenocarcinoma / pathology. Neovascularization, Pathologic / pathology. Stomach Neoplasms / pathology

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  • (PMID = 20016961.001).
  • [ISSN] 1532-2807
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / Keratin-18; 0 / Keratin-8; 0 / Vascular Endothelial Growth Factor A; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9
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96. Miquel C, Borrini F, Grandjouan S, Aupérin A, Viguier J, Velasco V, Duvillard P, Praz F, Sabourin JC: Role of bax mutations in apoptosis in colorectal cancers with microsatellite instability. Am J Clin Pathol; 2005 Apr;123(4):562-70
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  • We identified bax(G)8 mutations in 20 (49%) of 41 unstable tumors; the mutations were associated significantly with proximal, poorly differentiated, or mucinous adenocarcinomas.
  • [MeSH-major] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Apoptosis / genetics. Colorectal Neoplasms / genetics. Colorectal Neoplasms / pathology. Proto-Oncogene Proteins c-bcl-2 / genetics

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  • (PMID = 15743744.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BAX protein, human; 0 / Ki-67 Antigen; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; 0 / bcl-2-Associated X Protein
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97. Baltaziak M, Koda M, Wincewicz A, Sulkowska M, Kanczuga-Koda L, Sulkowski S: Relationships of P53 and Bak with EPO and EPOR in human colorectal cancer. Anticancer Res; 2009 Oct;29(10):4151-6
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  • RESULTS: Purely nuclear p53 was significantly higher expressed in the moderately differentiated cancers in comparison with the poorly differentiated ones (p=0.007).
  • [MeSH-major] Adenocarcinoma / metabolism. Colorectal Neoplasms / metabolism. Erythropoietin / metabolism. Receptors, Erythropoietin / metabolism. Tumor Suppressor Protein p53 / metabolism. bcl-2 Homologous Antagonist-Killer Protein / metabolism

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  • (PMID = 19846965.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / BAK1 protein, human; 0 / Receptors, Erythropoietin; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; 0 / bcl-2 Homologous Antagonist-Killer Protein; 11096-26-7 / Erythropoietin
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98. Schulman FY, Lipscomb TP, Atkin TJ: Canine cutaneous clear cell adnexal carcinoma: histopathology, immunohistochemistry, and biologic behavior of 26 cases. J Vet Diagn Invest; 2005 Sep;17(5):403-11
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  • The findings are consistent with a poorly differentiated, low-grade, adnexal carcinoma of the skin.
  • [MeSH-major] Adenocarcinoma, Clear Cell / veterinary. Carcinoma, Skin Appendage / veterinary. Dog Diseases / pathology. Skin Neoplasms / veterinary

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  • (PMID = 16312230.001).
  • [ISSN] 1040-6387
  • [Journal-full-title] Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • [ISO-abbreviation] J. Vet. Diagn. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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99. Rong ZX, Fang CH, Zhu DJ, Liu SJ: [Expression of Smo protein and the downstream transcription factor Gli1 protein in Sonic hedgehog signal transduction pathway in gastric carcinoma]. Nan Fang Yi Ke Da Xue Xue Bao; 2006 Dec;26(12):1728-31
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  • RESULTS: Only weak expression, if any, of Smo and Gli1 proteins was detected in normal gastric mucosa, but in papillary adenocarcinoma, tubular adenocarcinoma and poorly differentiated adenocarcinoma, their expressions were significant increased as the differentiation degree was lowered.
  • CONCLUSION: The abnormal activity of Sonic hedgehog signal transduction pathway may play an important role in the occurrence of papillary adenocarcinoma, tubular adenocarcinoma and poorly differentiated adenocarcinoma, and this abnormality is associated with Smo protein overexpression, which upregulates the expression of the downstream transcription factor Gli1 protein.
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenocarcinoma / physiopathology. Adult. Aged. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 17259107.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / GLI1 protein, human; 0 / Hedgehog Proteins; 0 / Receptors, G-Protein-Coupled; 0 / SMO protein, human; 0 / Transcription Factors
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100. Xu HT, Ma L, Qi FJ, Liu Y, Yu JH, Dai SD, Zhu JJ, Wang EH: Expression of serine threonine kinase 15 is associated with poor differentiation in lung squamous cell carcinoma and adenocarcinoma. Pathol Int; 2006 Jul;56(7):375-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of serine threonine kinase 15 is associated with poor differentiation in lung squamous cell carcinoma and adenocarcinoma.
  • The purpose of the present study was to investigate the expression of STK15 in lung squamous cell carcinoma and adenocarcinoma and analyze the correlation between STK15 expression and clinicopathological factors.
  • The STK15 expression was significantly higher in poorly differentiated lung cancers than in well-differentiated or moderately differentiated lung cancers (P = 0.011).
  • [MeSH-major] Adenocarcinoma / enzymology. Carcinoma, Squamous Cell / enzymology. Lung Neoplasms / enzymology. Protein-Serine-Threonine Kinases / metabolism

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  • (PMID = 16792546.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA, Messenger; EC 2.7.11.1 / AURKA protein, human; EC 2.7.11.1 / Aurora Kinase A; EC 2.7.11.1 / Aurora Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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