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1. Galie N, Vasile R, Savu C, Petreanu C, Grigorie V, Tabacu E: [Superior vena cava syndrome--surgical solution--case report]. Chirurgia (Bucur); 2010 Nov-Dec;105(6):835-8
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  • The histological diagnosis of the mediastinal tumor was adenocarcinoma tubular-papillary moderately differentiated.
  • [MeSH-major] Adenocarcinoma, Papillary / surgery. Mediastinal Neoplasms / surgery. Superior Vena Cava Syndrome / surgery

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  • (PMID = 21355182.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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2. Shi H, Lu D, Shu Y, Shi W, Lu S, Wang K: Expression of multidrug-resistance-related proteins P-glycoprotein, glutathione-S-transferases, topoisomerase-II and lung resistance protein in primary gastric cardiac adenocarcinoma. Cancer Invest; 2008 May;26(4):344-51
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  • [Title] Expression of multidrug-resistance-related proteins P-glycoprotein, glutathione-S-transferases, topoisomerase-II and lung resistance protein in primary gastric cardiac adenocarcinoma.
  • However, the clinical significance of the expression of MDR-related proteins p-glycoprotein (PGP), glutathione-s-transferases (GST-pi), topoisomerase-II (Topo-II) and lung resistance protein (LRP) in primary gastric cardiac adenocarcinoma (PGCA) remains unclear.
  • No significant correlation was shown between PGP and increasing differentiated degree (40%, 42.4% and 61.5%, P > 0.05).
  • GST-pi expression status progressively increased with increasing differentiated degree (40%, 75.8% and 88.5%, P < 0.05) and clinicopathologic stage (staging 1/2 vs 3/4, 57.1% vs 83.3%, P < 0.05).
  • The expression of Topo-II was associated with increasing differentiated degree (33.3%, 69.7 and 80.7%, P < 0.01).
  • Comparing the well, moderately and poorly differentiated cohort, a non-statistical increasing trend towards LRP expression status was noted (50.0%, 54.5% and 65.3%, respectively, P > 0.05).
  • [MeSH-major] Adenocarcinoma / chemistry. Cardia / chemistry. DNA Topoisomerases, Type II / analysis. Drug Resistance, Multiple / genetics. Drug Resistance, Neoplasm / genetics. Gene Expression Regulation, Neoplastic. Glutathione S-Transferase pi / analysis. Neoplasm Proteins / analysis. P-Glycoprotein / analysis. Stomach Neoplasms / chemistry. Vault Ribonucleoprotein Particles / metabolism

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  • (PMID = 18443954.001).
  • [ISSN] 1532-4192
  • [Journal-full-title] Cancer investigation
  • [ISO-abbreviation] Cancer Invest.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / P-Glycoprotein; 0 / Vault Ribonucleoprotein Particles; 0 / major vault protein; EC 2.5.1.18 / GSTP1 protein, human; EC 2.5.1.18 / Glutathione S-Transferase pi; EC 5.99.1.3 / DNA Topoisomerases, Type II
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3. Sofuni A, Iijima H, Moriyasu F, Nakayama D, Shimizu M, Nakamura K, Itokawa F, Itoi T: Differential diagnosis of pancreatic tumors using ultrasound contrast imaging. J Gastroenterol; 2005 May;40(5):518-25
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  • The one papillary adenocarcinoma showed a hypervascular and hyperperfusion pattern; the 32 well or moderately differentiated adenocarcinomas showed a hypovascular and hypoperfusion pattern; and in the poorly differentiated adenocarcinomas, 2 cases of scirrhous type showed a hypovascular and hypoperfusion pattern, and the 4 cases of medullary type showed an isovascular and isoperfusion pattern.
  • [MeSH-major] Adenocarcinoma, Papillary / ultrasonography. Carcinoma, Pancreatic Ductal / ultrasonography. Contrast Media / pharmacology. Pancreatic Neoplasms / ultrasonography. Pancreatitis / ultrasonography

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  • (PMID = 15942718.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Contrast Media
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4. Kamoshita N, Makita F, Aiba M, Tokiniwa H, Nagashima T, Takeyoshi I, Ohwada S, Morishita Y: [Four cases of advanced colorectal cancer successfully treated with irinotecan plus 5-fluorouracil and l-leucovorin combination chemotherapy]. Gan To Kagaku Ryoho; 2005 Aug;32(8):1187-90
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  • We diagnosed moderately-differentiated adenocarcinoma of the colon in two patients and of the rectum in two patients.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colorectal Neoplasms / drug therapy

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  • (PMID = 16121927.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents, Phytogenic; 7673326042 / irinotecan; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin
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5. Peng YF, Gu J: Synchronous colorectal and lung cancer: report of three cases. World J Gastroenterol; 2008 Feb 14;14(6):969-73
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  • Pathological examination showed the colorectal cancer was a moderately differentiated adenocarcinoma and the lung cancer was a squamous cell carcinoma.


6. Sebzda T, Saleh Y, Gburek J, Andrzejak R, Gnus J, Siewinski M, Grzebieniak Z: Cathepsin D expression in human colorectal cancer: relationship with tumour type and tissue differentiation grade. J Exp Ther Oncol; 2005;5(2):145-50
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  • Positive staining was observed in 2 of 3 in well-differentiated (66%), 4 of 10 in moderately-differentiated (40%) and 4 of 5 in poorly-differentiated (80%), tubular adencarcinomas represented: 3 of 7 (42%) and 9 of 13 in invasive adencarcinoma (69%).
  • [MeSH-major] Adenocarcinoma / enzymology. Cathepsin D / analysis. Colorectal Neoplasms / enzymology

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  • (PMID = 16471040.001).
  • [ISSN] 1359-4117
  • [Journal-full-title] Journal of experimental therapeutics & oncology
  • [ISO-abbreviation] J. Exp. Ther. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.4.23.5 / Cathepsin D
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7. Tsai WC, Chao YC, Sheu LF, Lin YF, Nieh S, Chen A, Yu CP, Jin JS: EMMPRIN and fascin overexpression associated with clinicopathologic parameters of pancreatobiliary adenocarcinoma in Chinese people. APMIS; 2007 Aug;115(8):929-38
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  • [Title] EMMPRIN and fascin overexpression associated with clinicopathologic parameters of pancreatobiliary adenocarcinoma in Chinese people.
  • The aim of this study was to test whether expression of EMMPRIN and fascin correlates with clinicopathologic parameters of pancreatobiliary adenocarcinoma.
  • Immunohistochemical analysis of EMMPRIN and fascin was performed in 100 surgical specimens obtained from Chinese patients, including 18 well-differentiated, 62 moderately differentiated, and 20 poorly differentiated pancreatic and biliary adenocarcinomas.
  • [MeSH-major] Adenocarcinoma / chemistry. Antigens, CD147 / analysis. Biliary Tract Neoplasms / chemistry. Carrier Proteins / analysis. Microfilament Proteins / analysis. Pancreatic Neoplasms / chemistry

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  • (PMID = 17696949.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / BSG protein, human; 0 / Carrier Proteins; 0 / Microfilament Proteins; 136894-56-9 / Antigens, CD147; 146808-54-0 / fascin
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8. Márquez-Villalobos FO, Ambriz-González G, Romo-Sandoval HV, Velázquez-Ramírez GA, Alvarez-Villaseñor AS, González-Ojeda A: [Clinical predictors of staging in colorectal cancer]. Cir Cir; 2008 Jul-Aug;76(4):311-5
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  • Most tumors were well to mildly differentiated adenocarcinomas (88.9%).
  • All showed low sensitivity but moderately high specificity (rectal bleeding 89%, change in bowel habits 68%).
  • CONCLUSIONS: The majority of the patients were diagnosed with advanced stages of well-to-mildly differentiated adenocarcinomas.
  • Symptom evaluation as predictors for staging showed a low sensitivity and a moderately high specificity due to a late diagnosis of advanced tumors.
  • [MeSH-major] Adenocarcinoma / pathology. Colorectal Neoplasms / pathology. Neoplasm Staging

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  • (PMID = 18778541.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
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9. Murata Y, Ohkawa S, Amano A, Ueno M, Miyakawa K, Shiozawa M, Sugimasa Y, Hayashi H, Miyagi Y: [A resected case of metastatic pancreatic cancer from cecal carcinoma]. Nihon Shokakibyo Gakkai Zasshi; 2008 Jul;105(7):1070-7
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  • A 64-year-old woman underwent an ileocecectomy in July 2002 for ruptured cecal carcinoma, which was a well-differentiated adenocarcinoma, stage II, ss, ly0, v0, n (-).
  • The pancreatic tumor resembled the moderately differentiated cecal adenocarcinoma, both having p53 and k-ras point mutations in common, and it was diagnosed as a metastasis of the cecal carcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Cecal Neoplasms / pathology. Pancreatic Neoplasms / secondary

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  • (PMID = 18603853.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 25
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10. Yamaguchi Y, Ohshita A, Hironaka K, Emi M, Kawabuchi Y, Sakatani A, Arihiro K: Neoadjuvant therapy of rectal cancer using oral tegaful-uracil (UFT) plus concomitant radiotherapy--a case report. Hiroshima J Med Sci; 2005 Sep;54(3):87-91
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  • Histological analysis indicated moderately differentiated adenocarcinoma cells that were present at only 2 mm in diameter in the mucosal layer, 6 mm in the submucosal layer, and 1 mm or less in the muscular layer with scar formation.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / radiotherapy. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Rectal Neoplasms / drug therapy. Rectal Neoplasms / radiotherapy

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  • (PMID = 16180702.001).
  • [ISSN] 0018-2052
  • [Journal-full-title] Hiroshima journal of medical sciences
  • [ISO-abbreviation] Hiroshima J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil
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11. Yamamoto S, Ito T, Aizawa T, Miki M, Furusato M: The possibility of 'de novo' cancer in the prostate. Int J Urol; 2005 Apr;12(4):361-4
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  • MATERIALS AND METHODS: Latent prostate cancers found at autopsy were examined and 55 cancer foci with a poorly (Gleason grade 4 and 5) or moderately (Gleason grade 3) differentiated component were selected.
  • The 55 foci were separated into two groups: (i) foci with either a poorly or moderately differentiated component only (single differentiation group, SDG); and (ii) mixed foci with two or more types of differentiation components (mixed differentiation group, MDG).
  • [MeSH-major] Adenocarcinoma / pathology. Prostatic Intraepithelial Neoplasia / pathology. Prostatic Neoplasms / pathology

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  • (PMID = 15948722.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Australia
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12. Tsubaki M, Nemoto K, Yoda N, Hasimoto R, Sunagawa M, Masawa N: Sigmoid colon cancer with mediastinal lymph node metastases. Int Surg; 2007 Jul-Aug;92(4):209-13
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  • We herein report on a 74-year-old man who was hospitalized with multiple brain metastases and mediastinal lymph node metastasis from an adenocarcinoma of the sigmoid colon.
  • CT-guided aspiration biopsy cytology of the mediastinal tumor showed metastatic adenocarcinoma from a digestive tract tumor.
  • Pathological findings of the specimen showed a moderately differentiated adenocarcinoma that invaded to the subserosa, but no evidence of lymph node metastasis was found.

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  • (PMID = 18050829.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Contrast Media; 25BB7EKE2E / Barium Sulfate
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13. Lam AK, Ong K, Giv MJ, Ho YH: p16 expression in colorectal adenocarcinoma: marker of aggressiveness and morphological types. Pathology; 2008 Oct;40(6):580-5
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  • [Title] p16 expression in colorectal adenocarcinoma: marker of aggressiveness and morphological types.
  • AIM: The aim of the present study was to investigate the clinicopathological roles of p16 expression in a large cohort of patients with colorectal adenocarcinoma with tight methodology and close follow-up.
  • The p16 protein was more often detected in well or moderately differentiated colorectal adenocarcinoma than poorly differentiated colorectal adenocarcinoma (84% versus 63%, p = 0.009).
  • [MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Colorectal Neoplasms / metabolism. Colorectal Neoplasms / pathology. Cyclin-Dependent Kinase Inhibitor p16 / biosynthesis

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  • [ErratumIn] Pathology. 2008 Dec;40(7):734. Giv, Mahmound Jafari [corrected to Giv, Mahmoud Jafari]
  • (PMID = 18752124.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16
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14. Montalto SA, Hakmi A, Moth P, Raju KS, Coutts M, Papadopoulos AJ, Devaja O: Well differentiated endometrioid adenocarcinoma of the uterus: a cancer unit or centre case? Eur J Gynaecol Oncol; 2009;30(1):35-9
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  • [Title] Well differentiated endometrioid adenocarcinoma of the uterus: a cancer unit or centre case?
  • OBJECTIVE: The purpose of this study was to investigate what proportion of cases showing a well differentiated endometrioid endometrial adenocarcinoma in the hysterectomy specimen removed at two UK cancer centres had adverse pathological features or advanced stage disease at the time of presentation.
  • STUDY DESIGN: Ninety-eight patients who were operated on at either the South East London Cancer Centre, London or the Kent Oncology Centre, Maidstone had a histological diagnosis of well differentiated (grade 1) endometrioid adenocarcinoma in their hysterectomy specimen.
  • RESULTS: Of the initial 98 cases, 65 patients (66.3%) were referred with a preoperative curettage showing a well differentiated endometrioid adenocarcinoma, 25 cases (25.5%) were referred with atypical endometrial hyperplasia, seven patients (7.1%) were referred with a moderately differentiated endometrioid adenocarcinoma, and one case (1.0%) was referred with a possible malignant mixed Mullerian tumour.
  • Subsequent histological examination of the hysterectomy specimens revealed that all of these cases had a well differentiated endometrioid adenocarcinoma.
  • From our study, 33.6% of cases with a well differentiated endometrioid adenocarcinoma of the uterus were Stage Ic or more at the time of presentation; 12.2% were at least FIGO Stage Ic, eight patients (8.2%) were FIGO Stage IIa, seven patients (7.1%) were Stage IIb and six patients (6.1%) were Stage III.
  • CONCLUSION: A significant proportion (33.6%) of well differentiated tumours in a hysterectomy were found to have Stage Ic disease or more at the time of presentation, and thus full surgical staging including a lymphadenectomy should have been carried out in these cases.
  • Cases with a preoperative biopsy showing atypical hyperplasia or well differentiated adenocarcinoma should have a preoperative MRI scan or preferably an intraoperative frozen section examination to identify those cases with adverse pathological features which need to be fully staged with pelvic and paraaortic lymphadenectomy.

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  • (PMID = 19317254.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Italy
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15. Wang XP, Qiu FR, Liu GZ, Chen RF: Correlation between clinicopathology and expression of heat shock protein 70 and glucose-regulated protein 94 in human colonic adenocarcinoma. World J Gastroenterol; 2005 Feb 21;11(7):1056-9
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  • [Title] Correlation between clinicopathology and expression of heat shock protein 70 and glucose-regulated protein 94 in human colonic adenocarcinoma.
  • HSP70 and grp94 expressed higher in moderately- and poorly-differentiated colonic cancers than that in their adjacent tissues (93.7%, 87.5%; 100%, 90% vs 56.3%, 42.5%; P<0.01).
  • The HSP70 and grp94 expression in poorly-differentiated colonic cancers with metastasis is significantly higher than well-differentiated cancers without metastasis.

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  • (PMID = 15742415.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / HSP70 Heat-Shock Proteins; 0 / Membrane Proteins; 0 / glucose-regulated proteins
  • [Other-IDs] NLM/ PMC4250772
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16. Butte JM, Torres J, Duarte I, Zúñiga A: [Composite tumor of the colon with liver metastases]. Cir Esp; 2007 Aug;82(2):128-30
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  • Preoperative biopsies confirmed an adenocarcinoma.
  • Histological analysis showed moderately differentiated tubular adenocarcinoma combined with a poorly differentiated neuroendocrine carcinoma and metastases in 25 of 28 lymph nodes.
  • The 2 hepatic metastases showed areas of poorly differentiated neuroendocrine carcinoma.

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  • (PMID = 17785149.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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17. Adhami VM, Siddiqui IA, Sarfaraz S, Khwaja SI, Hafeez BB, Ahmad N, Mukhtar H: Effective prostate cancer chemopreventive intervention with green tea polyphenols in the TRAMP model depends on the stage of the disease. Clin Cancer Res; 2009 Mar 15;15(6):1947-53
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  • PURPOSE: We have shown previously that oral feeding of green tea polyphenols (GTP) to transgenic adenocarcinoma of the mouse prostate mice in a purely chemopreventive setting significantly inhibits prostate cancer development.
  • EXPERIMENTAL DESIGN: GTP infusion (0.1% in drinking water) to transgenic adenocarcinoma of the mouse prostate was initiated at ages representing different stage of the disease: (a) 6 weeks (group 1, normal prostate), (b) 12 weeks (group 2, prostatic intraepithelial neoplasia), (c) 18 weeks (group 3, well-differentiated adenocarcinoma), and (b) 28 weeks (group 4, moderately differentiated adenocarcinoma).

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  • (PMID = 19276266.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / P50 DK065303; United States / NIDDK NIH HHS / DK / P50 DK065303-01; United States / NCI NIH HHS / CA / R01 CA078809; United States / NCI NIH HHS / CA / R01 CA078809-10; United States / NCI NIH HHS / CA / R01 CA 78809; United States / NCI NIH HHS / CA / R01 CA120451-05; United States / NCI NIH HHS / CA / CA078809-10; United States / NCI NIH HHS / CA / R01 CA101039; United States / NCI NIH HHS / CA / R01 CA120451; United States / NCI NIH HHS / CA / R01 CA101039-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Flavonoids; 0 / Insulin-Like Growth Factor Binding Protein 3; 0 / Phenols; 0 / Polyphenols; 0 / Tea; 67763-96-6 / Insulin-Like Growth Factor I
  • [Other-IDs] NLM/ NIHMS251985; NLM/ PMC2991083
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18. Vincan E, Darcy PK, Smyth MJ, Thompson EW, Thomas RJ, Phillips WA, Ramsay RG: Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth. Differentiation; 2005 Apr;73(4):142-53
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  • Using the ectodomain as an antagonist we have modulated endogenous FZD7 signalling in the moderately differentiated colon adenocarcinoma cell line, SK-CO-1.
  • [MeSH-major] Adenocarcinoma / pathology. Colonic Neoplasms / pathology. Receptors, G-Protein-Coupled / metabolism

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  • (PMID = 15901282.001).
  • [ISSN] 0301-4681
  • [Journal-full-title] Differentiation; research in biological diversity
  • [ISO-abbreviation] Differentiation
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / FZD7 protein, human; 0 / Frizzled Receptors; 0 / Integrin alpha6; 0 / Receptors, G-Protein-Coupled
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19. Liu F, Wang H, Zheng JM, Fu CG: [Accuracy comparison of preoperative histological assessment in differentiation and grading of rectal adenocarcinoma]. Zhonghua Wei Chang Wai Ke Za Zhi; 2010 Aug;13(8):577-9
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  • [Title] [Accuracy comparison of preoperative histological assessment in differentiation and grading of rectal adenocarcinoma].
  • OBJECTIVE: To compare the accuracy of preoperative assessment in differentiation and grading of rectal adenocarcinoma.
  • Patients were then divided into two groups based on the preoperative differentiation:the low-grade tumor including well and moderately differentiated tumors, and the high-grade tumor consisting of poorly differentiated and undifferentiated tumors.
  • [MeSH-major] Adenocarcinoma / pathology. Rectal Neoplasms / pathology

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  • (PMID = 20737307.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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20. Alì G, Donati V, Loggini B, Servadio A, Dell'Omodarme M, Prati MC, Camacci T, Lucchi M, Melfi F, Mussi A, Fontanini G: Different estrogen receptor beta expression in distinct histologic subtypes of lung adenocarcinoma. Hum Pathol; 2008 Oct;39(10):1465-73
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  • [Title] Different estrogen receptor beta expression in distinct histologic subtypes of lung adenocarcinoma.
  • Adenocarcinoma is becoming the most common histologic type of lung cancer in both sex.
  • Several subtypes of lung adenocarcinoma have been recently described with distinct clinicopathologic features and prognostic implications.
  • The purpose of this study is to investigate the role of estrogen receptor beta in lung adenocarcinoma, with particular attention paid to its different histologic subtypes.
  • Furthermore, a strong association between estrogen receptor beta expression and tumor histologic grade was observed: estrogen receptor beta was highly expressed predominantly in well- and moderately differentiated tumors (P = .0014).
  • In conclusion, estrogen receptor beta expression has distinct patterns in lung adenocarcinoma, suggesting a specific role for estrogen receptor beta in the pathogenesis of different histologic subtypes of this type of cancer.
  • Moreover, loss of estrogen receptor beta expression in poorly differentiated (G3) tumors could represent a crucial step in the dedifferentiation process of lung adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / metabolism. Estrogen Receptor beta / metabolism. Lung Neoplasms / metabolism

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  • (PMID = 18620727.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Estrogen Receptor beta
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21. Ohzeki T, Mori Y, Katoh Y, Iguchi M, Yamasaki M: [A case of prostate cancer that developed following transurethral resection of the prostate: diagnostic efficiency of diffusion-weighted images on magnetic resonance imaging]. Hinyokika Kiyo; 2010 May;56(5):277-80
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  • He had a moderately high prostate specific antigen (PSA) level of 4.5 ng/ml before TURP, but without pathological malignancy.
  • A poorly differentiated adenocarcinoma was detected in TUR-derived tissue fragments of the tumor protruding from the prostate.
  • [MeSH-major] Adenocarcinoma / diagnosis. Diffusion Magnetic Resonance Imaging. Prostatic Neoplasms / diagnosis. Transurethral Resection of Prostate

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  • (PMID = 20519927.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen
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22. Abe T, Hayashi T, Nakayama J, Kishikawa H, Sekii K, Yoshioka T, Itatani H, Kojima Y, Takahara S: [A case of synchronous double primary cancers of prostate, and bladder in a hemodialysis patient: a case report]. Hinyokika Kiyo; 2005 Oct;51(10):689-93
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  • The histologic diagnosis of the transrectal needle prostate biopsy specimen was moderately differentiated adenocarcinoma.
  • A case of synchronous double primary cancers, comprised of adenocarcinoma of the prostate and transitional cell carcinoma of the urinary blader in a hemodialysis patient has never been previously reported in the Japanese literature.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Transitional Cell / diagnosis. Neoplasms, Multiple Primary. Prostatic Neoplasms / diagnosis. Renal Dialysis. Urinary Bladder Neoplasms / diagnosis


23. Kim DY, Joo JK, Ryu SY, Park YK, Kim YJ, Kim SK: Clinicopathologic characteristics of gastric carcinoma in elderly patients: a comparison with young patients. World J Gastroenterol; 2005 Jan 7;11(1):22-6
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  • Significantly more elderly patients had a well or moderately differentiated histology, and more young patients had a poorly differentiated histology and signet ring cell carcinoma (P<0.001).
  • [MeSH-major] Adenocarcinoma, Mucinous / mortality. Adenocarcinoma, Mucinous / pathology. Aging. Carcinoma, Signet Ring Cell / mortality. Carcinoma, Signet Ring Cell / pathology. Stomach Neoplasms / mortality. Stomach Neoplasms / pathology

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  • (PMID = 15609390.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4205377
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24. Nakata S, Nakano K, Takahashi H, Shimizu K, Higashi H, Ohki K: [A case of prostate cancer diagnosed pathologically by bone metastatic site biopsy]. Nihon Hinyokika Gakkai Zasshi; 2005 May;96(4):507-10
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  • On right pubic bone biopsy, poorly to moderately differentiated adenocarcinoma was detected.
  • [MeSH-major] Adenocarcinoma / diagnosis. Bone Neoplasms / secondary. Bone and Bones / pathology. Prostatic Neoplasms / diagnosis. Pubic Bone


25. Ferrone CR, Brennan MF, Gonen M, Coit DG, Fong Y, Chung S, Tang L, Klimstra D, Allen PJ: Pancreatic adenocarcinoma: the actual 5-year survivors. J Gastrointest Surg; 2008 Apr;12(4):701-6
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  • [Title] Pancreatic adenocarcinoma: the actual 5-year survivors.
  • BACKGROUND: Most reports of patients undergoing resection for pancreatic adenocarcinoma report estimated (actuarial) 5-year survival rates.
  • METHODS: Review of a prospectively maintained database identified 618 patients who underwent resection for pancreatic adenocarcinoma between 1/1983-1/2001.
  • Adjuvant therapy was received by 21% (16 out of 75), and tumors were moderately differentiated in 58% (42 out of 75) and had a median size of 2.8 cm (0.8-13 cm).
  • CONCLUSIONS: Actual 5-year survival after resection of pancreatic adenocarcinoma was 12%.
  • [MeSH-major] Adenocarcinoma / mortality. Pancreatic Neoplasms / mortality

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  • (PMID = 18027062.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Mizushima T, Ito T, Mizuno H, Souma Y, Kainuma S, Yamanaka H, Ozawa H, Kanou T, Nakamori Y, Iwase K: [A case of recurrent colon cancer responding completely to uracil/tegafur (UFT) plus oral leucovorin (LV) therapy]. Gan To Kagaku Ryoho; 2005 Dec;32(13):2129-31
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  • Histological diagnosis was moderately differentiated adenocarcinoma, ss, n(-), P 0, H 0, M (-), stage II.
  • [MeSH-major] Adenocarcinoma / drug therapy. Colonic Neoplasms / drug therapy. Neoplasm Recurrence, Local / drug therapy

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  • (PMID = 16352943.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / UFT(R) drug; 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; Q573I9DVLP / Leucovorin
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27. Ohi S, Hashimoto H, Tachibana T, Tabei I, Nakajima M, Sato K, Yanaga K, Ishikawa H: Establishment and characterization of EB virus-free normal B-lymphocyte and interleukin-6-producing poorly differentiated adenocarcinoma cell lines derived from gastric tumor tissue. Hum Cell; 2005 Mar;18(1):35-44
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  • [Title] Establishment and characterization of EB virus-free normal B-lymphocyte and interleukin-6-producing poorly differentiated adenocarcinoma cell lines derived from gastric tumor tissue.
  • We successfully established two cell lines, an adenocarcinoma cell line (designated as HIGS) and Epstein-Barr virus-free normal B-lymphocyte cell line (designated as HIGS-BL), derived from a moderately to poorly differentiated adenocarcinoma of the stomach, and examined their characteristics.
  • [MeSH-major] Adenocarcinoma. B-Lymphocytes. Interleukin-6 / biosynthesis. Stomach Neoplasms

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  • (PMID = 16130898.001).
  • [ISSN] 0914-7470
  • [Journal-full-title] Human cell
  • [ISO-abbreviation] Hum. Cell
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Culture Media, Conditioned; 0 / Interleukin-6; Q20Q21Q62J / Cisplatin
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28. Tomizawa Y, Iijima H, Sunaga N, Sato K, Takise A, Otani Y, Tanaka S, Suga T, Saito R, Ishizuka T, Dobashi K, Minna JD, Nakajima T, Mori M: Clinicopathologic significance of the mutations of the epidermal growth factor receptor gene in patients with non-small cell lung cancer. Clin Cancer Res; 2005 Oct 1;11(19 Pt 1):6816-22
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  • EGFR mutation was significantly more frequent in females (47%) than males (12%, P < 0.0001), in younger patients (38%) than older patients (10%, P = 0.0005), in nonsmokers (47%) than smokers (13%, P < 0.0001), and in well-differentiated tumors (39%) than moderately and poorly differentiated tumors (7%, P < 0.0001).
  • CONCLUSIONS: These results in Japanese (East Asian) patients indicated that EGFR mutation plays an important role in pathogenesis of lung adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / genetics. Carcinoma, Non-Small-Cell Lung / genetics. Gene Expression Regulation, Neoplastic. Lung Neoplasms / genetics. Mutation. Receptor, Epidermal Growth Factor / genetics

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  • (PMID = 16203769.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA71618; United States / NCI NIH HHS / CA / P50CA70907
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers; 0 / Quinazolines; 0 / RASSF1 protein, human; 0 / Tumor Suppressor Proteins; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras); S65743JHBS / gefitinib
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29. Liu W, Zhu J, Cao L, Rodgers GP: Expression of hGC-1 is correlated with differentiation of gastric carcinoma. Histopathology; 2007 Aug;51(2):157-65
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  • Enhanced hGC-1 expression was more frequently seen in intestinal-type adenocarcinoma, whereas loss of expression tended to occur in the diffuse type. hGC-1 was highly expressed in well or moderately differentiated cancers and was remarkably reduced or lost in poorly differentiated or undifferentiated tumours.
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Cell Differentiation. Gastrointestinal Tract / metabolism. Gene Expression. Humans. Immunohistochemistry. Protein Array Analysis

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  • (PMID = 17650212.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / OLFM4 protein, human; 143011-72-7 / Granulocyte Colony-Stimulating Factor
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30. Barauskas G, Gulbinas A, Pundzius J: Results of surgical treatment of carcinoma of papilla of Vater. Medicina (Kaunas); 2007;43(6):455-62
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  • Adenocarcinoma is the most common malignant tumor of the ampulla, but in general, it is still rare.
  • To evaluate immediate postoperative and long-term results, we have collected data prospectively in a specially created database on 21 consecutive patients with adenocarcinoma of the papilla of Vater, operated on at the Department of Surgery, Kaunas University of Medicine Hospital.
  • Patients with highly or moderately differentiated tumors (G1, G2) survived better than patients with poor cell differentiation (G3), though significant difference was not achieved.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / surgery

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  • (PMID = 17637516.001).
  • [ISSN] 1648-9144
  • [Journal-full-title] Medicina (Kaunas, Lithuania)
  • [ISO-abbreviation] Medicina (Kaunas)
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Lithuania
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31. Kanda T, Yoshida H, Mamada Y, Taniai N, Kawano Y, Mizuguchi Y, Shimizu T, Takahashi T, Ueda J, Kato S, Akimaru K, Tajiri T, Fukuda Y: Resection of liver metastases from an alpha-fetoprotein-producing gastric cancer. J Nippon Med Sch; 2005 Feb;72(1):66-70
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  • The tumor was a moderately differentiated tubular adenocarcinoma with invasion of the muscularis propria.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / surgery. Biomarkers, Tumor / biosynthesis. Hepatectomy. Liver Neoplasms / secondary. Liver Neoplasms / surgery. Stomach Neoplasms / pathology. alpha-Fetoproteins / biosynthesis

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  • (PMID = 15834210.001).
  • [ISSN] 1345-4676
  • [Journal-full-title] Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
  • [ISO-abbreviation] J Nippon Med Sch
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha-Fetoproteins
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32. Shinohara N, Harabayashi T, Suzuki S, Nakamura M, Itoh T, Nonomura K: Advanced renal pelvic carcinoma associated with dermatomyositis. Int J Urol; 2005 Oct;12(10):906-8
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  • The pathological specimen showed moderately differentiated adenocarcinoma, stage pT3N2.
  • [MeSH-major] Adenocarcinoma / etiology. Dermatomyositis / complications. Kidney Neoplasms / etiology

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  • (PMID = 16323985.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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33. Theodoropoulos VE, Tsigka A, Mihalopoulou A, Tsoukala V, Lazaris AC, Patsouris E, Ghikonti I: Evaluation of neuroendocrine staining and androgen receptor expression in incidental prostatic adenocarcinoma: prognostic implications. Urology; 2005 Oct;66(4):897-902
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  • [Title] Evaluation of neuroendocrine staining and androgen receptor expression in incidental prostatic adenocarcinoma: prognostic implications.
  • Well-differentiated tumors revealed an overexpression of ARs (P < 0.005).
  • On multivariate analysis, worsening tumor differentiation emerged as the only independent predictor of progression-free survival (P = 0.041); however, only CgA positivity was an independent predictor of tumor progression in well and moderately differentiated tumors (P = 0.038).
  • CONCLUSIONS: The results of this study suggest that CgA may represent a useful marker for subsequent aggressive behavior and progression in incidental well and moderately differentiated Stage T1a PCa.
  • [MeSH-major] Adenocarcinoma / chemistry. Adenocarcinoma / pathology. Prostatic Neoplasms / chemistry. Prostatic Neoplasms / pathology. Receptors, Androgen / analysis

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  • (PMID = 16230178.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromogranin A; 0 / Chromogranins; 0 / Receptors, Androgen
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34. Wu CY, Lee WH, Wang JY, Chiang H, Chang JL, Tsai WC, Sheu LF, Jin JS: Tissue microarray-determined expression profiles of cyclooxygenase-2 in colorectal adenocarcinoma: association with clinicopathological parameters. Chin J Physiol; 2006 Dec 31;49(6):298-304
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  • [Title] Tissue microarray-determined expression profiles of cyclooxygenase-2 in colorectal adenocarcinoma: association with clinicopathological parameters.
  • Immunohistochemical analysis of COX-2 was performed in tissue microarray slides containing 90 specimens including 32 well-differentiated, 35 moderately differentiated, and 23 poorly differentiated colorectal adenocarcinomas.
  • However, there was no significant difference in immunostaining scores between poorly, moderately, and well-differentiated tumors (195 +/- 28, 214 +/- 26 and 200 +/- 24, respectively).
  • The positive expression rates of CK20 were 97% for well-differentiated, 94% for moderately differentiated, and 65% for poorly differentiated colorectal adenocarcinomas, suggesting that CK20 may not be an effective discriminator between poorly differentiated colorectal adenocarcinoma and metastatic adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / enzymology. Colorectal Neoplasms / enzymology. Cyclooxygenase 2 / metabolism

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  • (PMID = 17357536.001).
  • [ISSN] 0304-4920
  • [Journal-full-title] The Chinese journal of physiology
  • [ISO-abbreviation] Chin J Physiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China (Republic : 1949- )
  • [Chemical-registry-number] EC 1.14.99.1 / Cyclooxygenase 2
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35. Bhurgri Y, Pervez S, Kayani N, Haider S, Ahmed R, Usman A, Bashir I, Bhurgri A, Hasan SH, Zaidi SM: Rising incidence of gastric malignancies in Karachi, 1995- 2002. Asian Pac J Cancer Prev; 2009 Jan-Mar;10(1):41-4
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  • The majority of the cases presented as poorly or moderately differentiated distal (non-cardia) cancers with a regional spread.
  • Larger pathology-based studies are required to comment on the precise morphological sub-types of gastric adenocarcinoma.

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  • (PMID = 19469622.001).
  • [ISSN] 2476-762X
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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36. Hanprasertpong J, Sakolprakraikij S, Geater A: Endometrial cancer in Thai women aged 45 years or younger. Asian Pac J Cancer Prev; 2008 Jan-Mar;9(1):58-62
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  • Seven cases (13.7%) had synchronous ovarian cancer with endometriod adenocarcinoma as the most common histopathological form.
  • Forty patients had well differentiated, 8 moderately differentiated and 2 poorly differentiated tumors.
  • We conclude that the majority of women aged 45 years or younger with endometrial cancer were obese and the tumors were most commonly in an early stage and were well differentiated.
  • [MeSH-major] Adenocarcinoma / pathology. Endometrial Neoplasms / pathology

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  • (PMID = 18439075.001).
  • [ISSN] 2476-762X
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Thailand
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37. Lindahl B, Måsbäck A, Persson J, Ranstam J, Willlén R: Adenocarcinoma corpus uteri stage I-II: results of a treatment programme based upon cytometry. Anticancer Res; 2009 Nov;29(11):4731-5
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  • [Title] Adenocarcinoma corpus uteri stage I-II: results of a treatment programme based upon cytometry.
  • The results of a treatment method on adenocarcinoma corpus uteri stage I-II based upon cytometrically measured DNA ploidy are presented.
  • A total of 1,634 women with endometroid adenocarcinoma corpus uteri stage I-II were included where 1,396 patients were followed-up for at least 5 years or until death and the remaining 238 patients were followed-up 3.5-5 years or until death.
  • By using grade only (well- and moderately differentiated vs poorly differentiated), the low-risk group comprised 87% of the patients (with 4.6% dead from their disease) and the high-risk group 13% (with 13% dead from their disease).

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  • (PMID = 20032427.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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38. Won HJ, Ha TK, Kwon SJ, Cho HY, Hur SJ, Baik HH, Suh SI, Ha E, Kim YH: Differential effects of 5-fluorouracil on glucose transport and expressions of glucose transporter proteins in gastric cancer cells. Anticancer Drugs; 2010 Mar;21(3):270-6
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  • We hypothesized that the sensitivity of gastric cancer to 5-FU treatment might be related to the rate of glucose transport (GLUT), and investigated the expressions of GLUT1, 2, 3, and 4 in two different gastric cancer cells (SNU-216, moderately differentiated gastric adenocarcinoma; and SNU-668, signet ring cell gastric carcinoma).

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  • (PMID = 20023572.001).
  • [ISSN] 1473-5741
  • [Journal-full-title] Anti-cancer drugs
  • [ISO-abbreviation] Anticancer Drugs
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Glucose Transport Proteins, Facilitative; EC 2.7.1.1 / Hexokinase; EC 2.7.11.26 / Glycogen Synthase Kinase 3; IY9XDZ35W2 / Glucose; U3P01618RT / Fluorouracil
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39. Huh JW, Lee JH, Kim HR: Expression of p16, p53, and Ki-67 in colorectal adenocarcinoma: a study of 356 surgically resected cases. Hepatogastroenterology; 2010 Jul-Aug;57(101):734-40
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  • [Title] Expression of p16, p53, and Ki-67 in colorectal adenocarcinoma: a study of 356 surgically resected cases.
  • BACKGROUND/AIMS: The aim of the present study was to investigate the clinicopathological significance of p53, Ki-67, and p16 expression in patients with colorectal adenocarcinoma.
  • METHODOLOGY: We evaluated p53, Ki-67, and p16 expression in 356 patients with primary colorectal adenocarcinoma using an immunohistochemical staining method.
  • RESULTS: Positive p53 staining was detected more often in typical adenocarcinoma compared to mucinous adenocarcinoma (49% versus 17%, p = 0.007) and in well or moderately differentiated adenocarcinoma compared to poorly differentiated adenocarcinoma (50% versus 32%, p = 0.030).
  • The level of expression of p53 protein was related to lymph node metastasis (p < 0.001) and the TNM stage of the colorectal adenocarcinoma (p = 0.006).
  • CONCLUSIONS: Our data suggest that overexpression of p53, which was correlated with Ki-67 and p16 expression, plays a critical role in aggressive tumor behaviors in patients with colorectal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / metabolism. Colonic Neoplasms / metabolism. Gene Expression Regulation, Neoplastic. Ki-67 Antigen / metabolism. Neoplasm Proteins / metabolism. Rectal Neoplasms / metabolism. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 21033219.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Ki-67 Antigen; 0 / Neoplasm Proteins; 0 / P16 protein, human; 0 / Tumor Suppressor Protein p53
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40. Storey DJ, Rush R, Stewart M, Rye T, Al-Nafussi A, Williams AR, Smyth JF, Gabra H: Endometrioid epithelial ovarian cancer : 20 years of prospectively collected data from a single center. Cancer; 2008 May 15;112(10):2211-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Clinicopathological features and outcome of women with endometrioid and serous ovarian adenocarcinoma were compared.
  • Of these, 270 had pure endometrioid tumors; 659 had pure serous adenocarcinoma of the ovary.
  • RESULTS: Median age of diagnosis for patients with endometrioid tumors was younger than those with serous adenocarcinoma of the ovary (60 years vs 62 years; P = .013).
  • This relation remained for stage II and III disease and for moderately and poorly differentiated tumors.
  • CONCLUSIONS: Despite similar PBC response rates, endometrioid histology is associated with better survival compared with serous adenocarcinoma of the ovary, even with stage III or poorly differentiated tumors.


41. Ivanov K, Kolev N, Tonev A, Nikolova G, Krasnaliev I, Softova E, Tonchev A: Comparative analysis of prognostic significance of molecular markers of apoptosis with clinical stage and tumor differentiation in patients with colorectal cancer: a single institute experience. Hepatogastroenterology; 2009 Jan-Feb;56(89):94-8
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  • The blocked apoptosis and inability of the organism to "liquidate" the neoplastic transformation of the cell (loss/mutation of p53), which we establish in our study in the half the patients with high and moderately differentiated carcinoma and separately in 46% of the patients with favorable prognosis by clinical stage is a reason for fast progression, too.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Biomarkers, Tumor / metabolism. Colorectal Neoplasms / metabolism. Colorectal Neoplasms / pathology

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  • (PMID = 19453036.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / BAX protein, human; 0 / Biomarkers, Tumor; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; 0 / bcl-2-Associated X Protein
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42. Li CM, Han GL, Zhang SJ: [Detection of Epstein-Barr virus in lung carcinoma tissue by in situ hybridization]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi; 2007 Sep;21(3):288-90
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  • The positive rates of EBV infection in squamous cell carcinoma, adenocarcinoma, small cell carcinoma and large cell carcinoma were 35.9%, 31.6% 31.0%, 1/2, respectively.
  • Gender, age and clinicohistopathological type were not found to have any correlation with EBER1 expression, but EBER1 expression in groups of cases with poorly and moderately differentiated carcinomas was significantly higher than those in the group of cases with well differentiated carcinoma, and the EBER1 expression in the right lung was higher than in the left lung.

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  • (PMID = 17971949.001).
  • [ISSN] 1003-9279
  • [Journal-full-title] Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology
  • [ISO-abbreviation] Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Epstein-Barr virus encoded RNA 1; 0 / RNA, Viral
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43. Suzuki A, Kawamoto S, Inada K, Yamamoto N, Kojima T, Nagao S, Ochiai R: [A resected case of bleeding rectal cancer for Jehovah's Witness enabled with preceding colostomy and chemoradiation]. Gan To Kagaku Ryoho; 2009 Nov;36(12):2079-81
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  • Pathological findings showed moderately differentiated adenocarcinoma with Stage III a.

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  • (PMID = 20037329.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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44. Zuo ZG, Song HY, Li J, Xu C, Zhou ZH, Ni SC, Chen SQ: [Clinical application of intersphincteric resection in the anal-preserving operation for ultra-low rectal carcinoma]. Zhonghua Zhong Liu Za Zhi; 2009 Dec;31(12):941-4
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  • The pathological types were as follows: 28 cases of adenocarcinoma (11 were well differentiated, 17 moderately differentiated), 1 case of papillary carcinoma and 5 cases of villous adenoma with malignant change.
  • [MeSH-major] Adenocarcinoma / surgery. Anal Canal / surgery. Rectal Neoplasms / surgery. Rectum / surgery

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  • (PMID = 20193339.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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45. Juretzka MM, O'Hanlan KA, Katz SL, El-Danasouri I, Westphal LM: Embryo cryopreservation after diagnosis of stage IIB endometrial cancer and subsequent pregnancy in a gestational carrier. Fertil Steril; 2005 Apr;83(4):1041
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  • PATIENT(S): An infertile woman with endometrial biopsy demonstrating grade II/III moderately differentiated endometrial adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / surgery. Cryopreservation / methods. Embryo Transfer. Embryo, Mammalian / physiology. Endometrial Neoplasms / surgery. Infertility, Female / therapy. Pregnancy Outcome. Surrogate Mothers


46. Prosvic P, Brod'ák M, Odrázka K, Morávek P: [A case of an asynchronic triple tumorous disorder: a rectal adenocarcinoma, a carcinoma of the kidney and a prostatic adenocarcinoma--case report]. Rozhl Chir; 2005 Jan;84(1):41-5
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  • [Title] [A case of an asynchronic triple tumorous disorder: a rectal adenocarcinoma, a carcinoma of the kidney and a prostatic adenocarcinoma--case report].
  • In the year 1980 in 56 years old patient had histologically proven rectal adenocarcinoma and consequently was done radical Miles amputation of rectum.
  • In December 1991 in the same patient was histologically proven well differentiated adenocarcinoma of prostate after transurethral resection of prostate.
  • Histologically was proven moderately differentiated clear cell renal carcinoma.
  • [MeSH-major] Adenocarcinoma. Carcinoma, Renal Cell. Kidney Neoplasms. Neoplasms, Second Primary. Prostatic Neoplasms. Rectal Neoplasms

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  • (PMID = 15813456.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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47. Muroni M, D'Angelo F, Pezzatini M, Sebastiani S, Noto S, Pilozzi E, Ramacciato G: Synchronous gastric adenocarcinoma and pancreatic ductal adenocarcinoma. Hepatobiliary Pancreat Dis Int; 2010 Feb;9(1):97-9
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  • [Title] Synchronous gastric adenocarcinoma and pancreatic ductal adenocarcinoma.
  • Histological examination of the specimen demonstrated a moderately differentiated adenocarcinoma of the stomach and a poorly differentiated ductal adenocarcinoma of the pancreas.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Pancreatic Ductal / diagnosis. Neoplasms, Multiple Primary / diagnosis. Pancreatic Neoplasms / diagnosis. Stomach Neoplasms / diagnosis

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  • (PMID = 20133238.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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48. Mukherjee K, Peng D, Brifkani Z, Belkhiri A, Pera M, Koyama T, Koehler EA, Revetta FL, Washington MK, El-Rifai W: Dopamine and cAMP regulated phosphoprotein MW 32 kDa is overexpressed in early stages of gastric tumorigenesis. Surgery; 2010 Aug;148(2):354-63
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  • BACKGROUND: Gastric adenocarcinoma is a leading cause of cancer mortality.
  • RESULTS: The composite expression score (CES), calculated from immunostaining patterns, increased significantly from normal or gastritis to metaplasia, dysplasia, and adenocarcinoma (P < .001).
  • High median CES correlated with well- or moderately differentiated (P = .03) gastric adenocarcinomas.

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  • [Copyright] Copyright 2010 Mosby, Inc. All rights reserved.
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  • (PMID = 20580047.001).
  • [ISSN] 1532-7361
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / P30 DK058404-10; United States / NCI NIH HHS / CA / T32CA106183; United States / NCI NIH HHS / CA / P50 CA095103; United States / NCI NIH HHS / CA / P50 CA095103-10; United States / NCI NIH HHS / CA / T32 CA106183; United States / NCI NIH HHS / CA / R01CA93999; United States / NCI NIH HHS / CA / R01 CA093999; United States / NCI NIH HHS / CA / R01 CA093999-10; United States / NCI NIH HHS / CA / CA95103; United States / NCI NIH HHS / CA / CA093999-10
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dopamine and cAMP-Regulated Phosphoprotein 32; 0 / PPP1R1B protein, human; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / RNA, Small Interfering; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
  • [Other-IDs] NLM/ NIHMS209004; NLM/ PMC2919779
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49. Kim MJ, Hong SM, Jang SJ, Yu E, Kim JS, Kim KR, Gong G, Ro JY: Invasive colorectal micropapillary carcinoma: an aggressive variant of adenocarcinoma. Hum Pathol; 2006 Jul;37(7):809-15
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  • [Title] Invasive colorectal micropapillary carcinoma: an aggressive variant of adenocarcinoma.
  • We compared the clinicopathologic and immunohistochemical findings of MC with those of conventional adenocarcinoma in the large intestine.
  • Fifty-five cases of adenocarcinoma with an MC component were identified among 585 consecutive cases of colorectal cancer at the Asan Medical Center between January 2003 and June 2004 and were compared with 119 cases of conventional adenocarcinoma of colorectum without an MC component.
  • The grade of both MC and conventional adenocarcinoma was mostly moderately differentiated.
  • The presence but not extent of MC in the primary tumors was associated with more frequent lymphovascular invasion and lymph node (LN) metastases, a greater mean number of positive LNs, and a higher tumor stage with more frequent distant metastases, compared with conventional adenocarcinoma (P < .05).
  • Cytokeratin 7 staining was occasionally observed in both MC (9.1%, 5/55 cases) and conventional adenocarcinoma (13.4%, 16/119 cases).
  • Although MLH-1 and CDX2 expression tended to be lower in conventional adenocarcinoma, none of the immunohistochemical results was significantly different between 2 groups.
  • Recognition of MC component is important as MC appeared to be an aggressive variant of colonic adenocarcinoma and presented at a higher stage, with frequent lymphovascular invasion, LN metastasis, and distant metastasis, compared with conventional adenocarcinoma.
  • The proportion of MC component did not impact the prognosis, and the immunoprofiles of MC were not significantly different from those of conventional adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Colorectal Neoplasms / pathology

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  • (PMID = 16784979.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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50. Shidham VB, Komorowski RA, Machhi JK: Androgen receptor expression in metastatic adenocarcinoma in females favors a breast primary. Diagn Pathol; 2006;1:34
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  • [Title] Androgen receptor expression in metastatic adenocarcinoma in females favors a breast primary.
  • BACKGROUND: The differential diagnosis of metastatic mammary adenocarcinoma and adenocarcinomas from other primary sites can be challenging, particularly in tumors that are poorly differentiated and negative for Estrogen/Progesterone receptors (ER/PR).
  • This study was undertaken to evaluate the diagnostic significance of AR expression in adenocarcinoma of breast and other morphologically similar adenocarcinomas.
  • DESIGN: Formalin-fixed paraffin-embedded tissue sections of 113 primary adenocarcinoma of various sites [breast (34, all females), lung (23, M- 6, F-17), colon (9, M-2, F-7), stomach (6, M-4, F-2), liver and bile duct (11, M-5, F-6), pancreas (7, M-2, F-5), ovary (10), endometrium (7), and cervix (6)] were immunostained with monoclonal antibody for AR.
  • Except for well differentiated lobular carcinoma of breast (5) and bronchoalveolar carcinoma of lung (10), majority of the tumors were moderately to poorly differentiated.
  • RESULTS: 56% (19/34) mammary carcinoma and 20% (2/10) adenocarcinoma of ovary were positive for AR.

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  • (PMID = 17020615.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1601970
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51. Jiang PH, Motoo Y, Garcia S, Iovanna JL, Pébusque MJ, Sawabu N: Down-expression of tumor protein p53-induced nuclear protein 1 in human gastric cancer. World J Gastroenterol; 2006 Feb 7;12(5):691-6
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  • TP53INP1 expression was significantly decreased (43.9%) in poorly differentiated adenocarcinoma compared with well or moderately differentiated adenocarcinoma (81.6%).
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Aged. Apoptosis. Down-Regulation. Female. Genes, p53. Humans. Male. Middle Aged. Prognosis. Stomach / metabolism. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 16521180.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / Heat-Shock Proteins; 0 / TP53 protein, human; 0 / TP53INP1 protein, human; 0 / Tumor Suppressor Protein p53
  • [Other-IDs] NLM/ PMC4066117
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52. Shioiri T, Inoue S, Kusano T, Umekita N, Kitamura M, Warabi M, Kawahara Y: [A case of advanced gastric cancer responding to neoadjuvant TS-1/CDDP chemotherapy]. Gan To Kagaku Ryoho; 2005 Sep;32(9):1327-30
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  • It was about 9 cm in diameter, and the biopsy specimen revealed moderately differentiated tubular adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymph Nodes / pathology. Stomach Neoplasms / drug therapy

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  • (PMID = 16184934.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / Pyridines; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; Q20Q21Q62J / Cisplatin
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53. Inagaki M, Goto J, Tokusashi Y, Miyokawa N, Yokoyama K, Ikeue S, Kasai S: Multifocal pancreatic intraepithelial neoplasia (PanIN) lesions of the branch ducts associated with lobular parenchymal atrophy in a Japanese patient diagnosed to have familial pancreatic cancer. Clin J Gastroenterol; 2009 Apr;2(2):103-108
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  • The histological findings of the main tumor showed a moderately differentiated tubular adenocarcinoma in the head of the pancreas without metastasis of the resected lymph nodes.

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  • (PMID = 26192174.001).
  • [ISSN] 1865-7257
  • [Journal-full-title] Clinical journal of gastroenterology
  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Familial pancreatic cancer / Lobular parenchymal atrophy / PanIN / Pancreatoduodenectomy
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54. Popivanova BK, Li YY, Zheng H, Omura K, Fujii C, Tsuneyama K, Mukaida N: Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis. Cancer Sci; 2007 Mar;98(3):321-8
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  • Pim-3 was detected immunohistochemically in well-differentiated (43/68 cases) and moderately differentiated (23/41 cases) but not poorly differentiated colon adenocarcinomas (0/5 cases).
  • Moreover, Pim-3 proteins were detected in adenoma (35/40 cases) and normal mucosa (26/111 cases), which are adjacent to adenocarcinoma.

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  • (PMID = 17270021.001).
  • [ISSN] 1347-9032
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins; 0 / bcl-Associated Death Protein; EC 2.7.11.1 / PIM3 protein, human; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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55. Hungerhuber E, Bach E, Hartmann A, Frimberger D, Stief C, Zaak D: Adenocarcinoma of the bladder following nephrogenic adenoma: a case report. J Med Case Rep; 2008;2:164
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  • [Title] Adenocarcinoma of the bladder following nephrogenic adenoma: a case report.
  • We report a case of post-traumatic nephrogenic adenoma in a young patient without immunosuppression, which transformed into an adenocarcinoma of the bladder.
  • The initial pathologic findings were benign, however, the last resection revealed that the former benign adenoma had transformed into a moderately differentiated adenocarcinoma of the bladder (tumor present but no invasion, multifocal, no lymph nodes involved, no metastasis, grade 2).

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  • (PMID = 18485239.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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56. Al-Hendal A, Al-Masri W, Al-Mishaan M, Alexander S: Abscess of the abdominal wall resulting from perforated ascending colon cancer. Gulf J Oncolog; 2009 Jan;(5):60-3
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  • Right hemicolectomy with lymph node dissection and en-bloc partial resection of the adherent parietal wall was performed and the final pathology showed a moderately differentiated mucinous adenocarcinoma.
  • [MeSH-major] Abdominal Abscess / etiology. Abdominal Wall / pathology. Adenocarcinoma, Mucinous / complications. Colonic Neoplasms / complications. Colonic Neoplasms / pathology. Intestinal Perforation / etiology

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  • (PMID = 20084789.001).
  • [ISSN] 2078-2101
  • [Journal-full-title] The Gulf journal of oncology
  • [ISO-abbreviation] Gulf J Oncolog
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Kuwait
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57. Geisinger KR, Travis WD, Perkins LA, Zakowski MF: Aspiration cytomorphology of fetal adenocarcinoma of the lung. Am J Clin Pathol; 2010 Dec;134(6):894-902
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  • [Title] Aspiration cytomorphology of fetal adenocarcinoma of the lung.
  • Fetal adenocarcinoma (FA) of the lung is an exceedingly rare malignancy.
  • Many patients with the well-differentiated form are relatively young and with the high-grade variant are older.
  • Aspirates were moderately cellular with malignant, mostly aggregated cells.
  • [MeSH-major] Adenocarcinoma / surgery. Lung Neoplasms / pathology

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  • (PMID = 21088152.001).
  • [ISSN] 1943-7722
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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58. Khalid K, Ahmed MS, Malik MS: Adenocarcinoma of urachal cyst associated with pseudomyxoma peritonei masquerading as abdominal tuberculosis: A case report and review of literature. Indian J Urol; 2008 Apr;24(2):258-60
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  • [Title] Adenocarcinoma of urachal cyst associated with pseudomyxoma peritonei masquerading as abdominal tuberculosis: A case report and review of literature.
  • Histopathology confirmed a moderately differentiated mucin secreting adenocarcinoma of urachal cyst associated with PMP.
  • The adenocarcinoma of urachal cyst associated with PMP is further reviewed.

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  • (PMID = 19468408.001).
  • [ISSN] 0970-1591
  • [Journal-full-title] Indian journal of urology : IJU : journal of the Urological Society of India
  • [ISO-abbreviation] Indian J Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2684289
  • [Keywords] NOTNLM ; Adenocarcinoma / pseudomyxoma peritonei / urachal cyst
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59. Yokoyama Y, Nishimura Y, Yatsuoka T, Sakamoto H, Tanaka Y, Nishimura Y, Kurosumi M: [A case of anal metastasis from sigmoid colon cancer in a long-term survivor who had repeated local excisions]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2585-7
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  • Histopathological examination revealed a moderately differentiated adenocarcinoma, tub 2, SS, ly2, v2, N1, H0, P0, M0, Stage IIIa, cur A.
  • It showed a submucosal tumor 15 mm in diameter at the anal canal and the biopsy indicated a moderately differentiated adenocarcinoma.
  • Histopathological examination revealed a moderately differentiated adenocarcinoma, which was the same histological type as primary sigmoid colon cancer, tub 2, A, ly2, v2, RM0.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Anus Neoplasms / secondary. Anus Neoplasms / surgery. Sigmoid Neoplasms / pathology

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  • (PMID = 21224647.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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60. Oishi C, Baba T, Kubota Y, Shimotsuma Y, Kitamura K, Honma T, Ikegami A, Inokuchi M, Umeda T, Yoshida H, Imawari M: [Two cases of gastric cancer expressing Glypican 3, but producing AFP with different lectin affinity]. Nihon Shokakibyo Gakkai Zasshi; 2009 Jun;106(6):805-12
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  • Although, in both cases, the biopsy specimens of the gastric neoplasm proved moderately to poorly differentiated adenocarcinoma without hepatoid differentiation, the localization of Glypican 3 in gastric cancer cells was observed using immunostaining with a monoclonal antibody.
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / analysis. Glypicans / analysis. Stomach Neoplasms / metabolism. alpha-Fetoproteins / biosynthesis

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  • (PMID = 19498312.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glypicans; 0 / alpha-Fetoproteins
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61. Veras E, Deavers MT, Silva EG, Malpica A: Ovarian nonsmall cell neuroendocrine carcinoma: a clinicopathologic and immunohistochemical study of 11 cases. Am J Surg Pathol; 2007 May;31(5):774-82
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  • In 2 cases, the tumor was associated with a mature cystic teratoma; one of them also containing an invasive moderately differentiated adenocarcinoma.

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  • (PMID = 17460463.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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62. Handa R, Kato T, Miyake Y, Oshima K, Oshima S, Iijima S, Yamamoto H, Kurokawa E, Kikkawa N: [A long term survival case of advanced colon cancer with adjacent organ involvement and multiple liver metastases]. Gan To Kagaku Ryoho; 2006 Nov;33(12):1795-7
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  • Histopathologically, it was a moderately differentiated adenocarcinoma with a biopsy examination.
  • [MeSH-major] Adenocarcinoma / secondary. Cecal Neoplasms / pathology. Liver Neoplasms / secondary

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  • (PMID = 17212110.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] U3P01618RT / Fluorouracil
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63. Yoshida N, Kochi M, Niide O, Watanabe Y, Mamiya T, Mochizuki S, Ohkubo T, Takayama T: [A case of advanced sigmoid colon cancer with peritoneal dissemination responding to FOLFOX4 therapy]. Gan To Kagaku Ryoho; 2008 Dec;35(13):2429-32
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  • Pathological examination of omental dissemination demonstrated moderately-differentiated adenocarcinoma.

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  • (PMID = 19098417.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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64. Shestakova T, Zhuravel E, Bolgova L, Zaitsev S, Efanova O, Soldatkina M, Pogrebnoy P: Immunohistochemical analysis of beta-defensin-2 expression in human lung tumors. Exp Oncol; 2010 Dec;32(4):273-6
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  • MATERIALS AND METHODS: Specimens of surgically resected human lung tumors (n = 31) of different histological type (1 case of small cell lung cancer, and 30 cases of non-small cell lung cancer (1 case of clear cell carcinoma, 9 cases of squamous cell carcinoma (SCC), and 20 cases of adenocarcinoma (AC)) were analyzed for expression of hBD-2 with the use of immunohistochemical analysis.
  • According to our observations, low-differentiated AC differs from moderately differentiated AC by significantly lower hBD-2 expression levels (p < 0.05).
  • CONCLUSION: Human beta-defensin-2 expression levels may depend on differentiation grade of lung adenocarcinoma.

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  • (PMID = 21270758.001).
  • [ISSN] 1812-9269
  • [Journal-full-title] Experimental oncology
  • [ISO-abbreviation] Exp. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ukraine
  • [Chemical-registry-number] 0 / DEFB4A protein, human; 0 / beta-Defensins
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65. Wu DL, Yi HX, Sui FY, Jiang XH, Jiang XM, Zhao YY: Expression of ATP7B in human gastric cardiac carcinomas in comparison with distal gastric carcinomas. World J Gastroenterol; 2006 Dec 21;12(47):7695-8
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  • ATP7B expression in poorly differentiated gastric cardiac carcinomas was significantly higher than that in well/moderately differentiated gastric cardiac carcinomas (P = 0.030).
  • [MeSH-major] Adenocarcinoma / metabolism. Adenosine Triphosphatases / metabolism. Cation Transport Proteins / metabolism. Esophageal Sphincter, Lower / metabolism. Stomach / metabolism. Stomach Neoplasms / metabolism

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  • (PMID = 17171802.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Cation Transport Proteins; EC 3.6.1.- / Adenosine Triphosphatases; EC 3.6.3.4 / Wilson disease protein
  • [Other-IDs] NLM/ PMC4088055
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66. Kanno H, Umemoto S, Izumi K, Hasumi H, Osada Y, Ohta J, Mikata K, Tuchiya F: [Prostate cancer development after transurethral resection of the prostate--histopathological studies of radical prostatectomy specimens]. Nihon Hinyokika Gakkai Zasshi; 2006 May;97(4):649-59
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  • Long term (5 or 10 years) MAB therapy changed moderately-differentiated adenocarcinoma (AC) to poorly-differentiated AC in 2 pts. during follow-up.
  • Thirteen Non-Stage A pts. showed aggressive ca. (6 moderately-differentiated AC, 6 poorly-differentiated AC, and 1 ductal carcinoma which showed metastasis later), most of which invaded widely in peripheral zone (PZ).

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  • (PMID = 16768146.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen
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67. Howman-Giles R, Holland AJ, Mihm D, Montfort JM, Arbuckle S, Kellie S: Somatic malignant transformation in a sacrococcygeal teratoma in a child and the use of F18FDG PET imaging. Pediatr Surg Int; 2008 Apr;24(4):475-8
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  • Biopsy revealed an adenocarcinoma most likely arising from a sacrococcygeal teratoma (SCT).
  • Radical abdomino-pelvic and gluteal surgery was performed with removal of the entire tumour confirmed as a moderately differentiated adenocarcinoma arising in an immature teratoma.
  • [MeSH-major] Adenocarcinoma. Fluorodeoxyglucose F18. Neoplasms, Multiple Primary. Positron-Emission Tomography. Radiopharmaceuticals. Teratoma

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  • (PMID = 17828545.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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68. Narui K, Ike H, Fujii S, Nojiri K, Tatsumi K, Yamagishi S, Saito S, Kunisaki C, Imada T, Nozawa A, Ohki S, Ota M, Ichikawa Y, Shimada H: [A case of radiation-induced rectal cancer]. Nihon Shokakibyo Gakkai Zasshi; 2006 May;103(5):551-7
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  • However, colonoscopy showed an ulcerative lesion of the rectum in December 2004, and pathological findings of the biopsy specimen disclosed moderately differentiated adenocarcinoma.
  • Predominant histological type of the tumor was moderately differentiated carcinoma followed by well differentiated type.
  • [MeSH-major] Adenocarcinoma / etiology. Neoplasms, Radiation-Induced. Radiotherapy / adverse effects. Rectal Neoplasms / etiology

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  • (PMID = 16734262.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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69. Seya T, Tanaka N, Yokoi K, Okada S, Oaki Y, Uchida E: Left paraduodenal hernia incidentally diagnosed during operation for transverse colon cancer. J Nippon Med Sch; 2010 Apr;77(2):111-4
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  • A biopsy of the mass was performed, and a moderately differentiated adenocarcinoma was diagnosed.
  • [MeSH-major] Adenocarcinoma / surgery. Colectomy. Colonic Neoplasms / surgery. Hernia, Abdominal / diagnosis. Incidental Findings. Intestinal Obstruction / diagnosis. Jejunal Diseases / diagnosis

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  • (PMID = 20453424.001).
  • [ISSN] 1345-4676
  • [Journal-full-title] Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
  • [ISO-abbreviation] J Nippon Med Sch
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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70. Campos MS, Modolo F, de Oliveira JS, Pinto-Júnior DS, de Sousa SC: Atypical presentation of oral basaloid squamous cell carcinoma. J Contemp Dent Pract; 2009;10(2):98-104
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  • Histologically, nests and cords of closely packed, moderately pleomorphic basaloid cells with nuclear palisading along the periphery of the neoplastic nests surrounded by a fibrous stroma were found.
  • SUMMARY: Since this tumor can mimic other neoplasms such as adenoid cystic carcinoma, neuroendocrine carcinoma, and basal cell adenocarcinoma, histological features are essential to differentiate between them.
  • CLINICAL SIGNIFICANCE: BSCC needs to be differentiated from other neoplasms as early as possible because of its adverse prognosis.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Neuroendocrine / diagnosis. Cell Nucleus / ultrastructure. Diagnosis, Differential. Follow-Up Studies. Humans. Immunohistochemistry. Keratins / analysis. Ki-67 Antigen / analysis. Laminin / analysis. Male. Middle Aged. Mitosis. Necrosis. Tumor Suppressor Protein p53 / analysis


71. Urbańczyk K, Limon J, Korobowicz E, Chosia M, Sygut J, Karcz D, Iwanik K, Osuch C, Lasota J, Stachura J: Gastrointestinal stromal tumors. A multicenter experience. Pol J Pathol; 2005;56(2):51-61
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  • Moderately and highly aggressive tumors predominated.
  • Synchronic tumors observed in patients with GISTs were seen in seven patients, including an adenocarcinoma of the colon, two adenocarcinomas of the stomach, a carcinoid tumor of the small intestine, a pheochromocytoma of the retroperitoneal space, an anaplastic lymphoma and a disseminated squamous cell carcinoma.
  • Immunohistochemical reactions were equally differentiated as to their presence and intensity in small tumors and in highly aggressive lesions above 5-10 cm in size.

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  • (PMID = 16092666.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] Poland
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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72. Banerjee S, Dhar G, Haque I, Kambhampati S, Mehta S, Sengupta K, Tawfik O, Phillips TA, Banerjee SK: CCN5/WISP-2 expression in breast adenocarcinoma is associated with less frequent progression of the disease and suppresses the invasive phenotypes of tumor cells. Cancer Res; 2008 Sep 15;68(18):7606-12
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  • [Title] CCN5/WISP-2 expression in breast adenocarcinoma is associated with less frequent progression of the disease and suppresses the invasive phenotypes of tumor cells.
  • Additionally, we showed that CCN5 mRNA and protein level was almost undetectable in poorly differentiated cancers compared with the moderately or well-differentiated samples and its expression inversely correlated with lymph node positivity.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Breast Neoplasms / metabolism. Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / metabolism. Carcinoma, Ductal, Breast / pathology. Intercellular Signaling Peptides and Proteins / biosynthesis. Transcription Factors / biosynthesis

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  • (PMID = 18794149.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / 1 P20 RR15563
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CCN Intercellular Signaling Proteins; 0 / Cadherins; 0 / Intercellular Signaling Peptides and Proteins; 0 / RNA, Messenger; 0 / Repressor Proteins; 0 / Transcription Factors; 0 / WISP2 protein, human; 0 / snail family transcription factors; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9
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73. Nikou GC, Marinou K, Thomakos P, Papageorgiou D, Sanzanidis V, Nikolaou P, Kosmidis C, Moulakakis A, Mallas E: Chromogranin a levels in diagnosis, treatment and follow-up of 42 patients with non-functioning pancreatic endocrine tumours. Pancreatology; 2008;8(4-5):510-9
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  • They are characterized by the absence of symptoms of hormone hypersecretion and frequently have clinical manifestations similar to the more common exocrine pancreatic adenocarcinoma.
  • Plasma CgA levels were significantly or moderately elevated in all patients with liver metastases at diagnosis (64.3%).
  • However, it was negative in 6 patients with liver metastases, in whom tumours were proved to be poorly differentiated (high-grade).

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 18765956.001).
  • [ISSN] 1424-3911
  • [Journal-full-title] Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
  • [ISO-abbreviation] Pancreatology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromogranin A
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74. Zhao L, Shen ZX, Luo HS, Yu JP: Clinical investigation on coexisting of duodenal ulcer and gastric cancer in China. Int J Clin Pract; 2005 Oct;59(10):1153-6
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  • 89.2% (33/37) of concurrent gastric cancer were in the corpus and antrum, with 78.1% (29/37) of them belonging to Bormann type II and 87.1% (27/37) being moderately differentiated adenocarcinoma.

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  • (PMID = 16178981.001).
  • [ISSN] 1368-5031
  • [Journal-full-title] International journal of clinical practice
  • [ISO-abbreviation] Int. J. Clin. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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75. Yamac D, Celenkoglu G, Coskun U, Akyurek N, Akcali Z, Dursun A, Koybasioglu F: Prognostic importance of COX-2 expression in patients with colorectal cancer. Pathol Res Pract; 2005;201(7):497-502
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  • There was no relationships between COX-2 expression and tumor size (tm < 3 cm or tm > or = 3 cm), tumor histopathological differentiation (poorly differentiated or moderately + well differentiated), number of metastatic lymph nodes (< 4 or 3 > or = 4), histopathology of the tumor, localization of the tumor (colon or rectum), distant metastasis, and vascular invasion of the tumor.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Biomarkers, Tumor / analysis. Colorectal Neoplasms / metabolism. Colorectal Neoplasms / pathology. Prostaglandin-Endoperoxide Synthases / biosynthesis

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  • (PMID = 16164044.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Membrane Proteins; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases
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76. Melliou A, Theocharidis G, Helis L, Makridis J, Patakiouta F, Kouroussis C: Carcinoma of sigmoid colon after ureterosigmoidostomy. J BUON; 2005 Oct-Dec;10(4):551-3
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  • An unusual case of adenocarcinoma of the colon in a 49-year-old man is described.
  • The histology revealed a metastatic, moderately differentiated mucinous adenocarcinoma, probably of the bowel.

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  • (PMID = 17357215.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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77. Saleh Y, Sebzda T, Warwas M, Kopec W, Ziólkowska J, Siewinski M: Expression of cystatin C in clinical human colorectal cancer tissues. J Exp Ther Oncol; 2005;5(1):49-53
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  • The percentages of positive staining were greater for adenocarcinoma than carcinoma,100% and 77% respectively.
  • Antipapain activity which was increased in malignant tissues in comparison to control, rose successively from well differentiated carcinomas through moderately to poor differentiated.
  • [MeSH-major] Adenocarcinoma / metabolism. Carcinoma / metabolism. Colorectal Neoplasms / metabolism. Cystatins / biosynthesis

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  • (PMID = 16416601.001).
  • [ISSN] 1359-4117
  • [Journal-full-title] Journal of experimental therapeutics & oncology
  • [ISO-abbreviation] J. Exp. Ther. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CST3 protein, human; 0 / Cystatin C; 0 / Cystatins; 0 / Cysteine Proteinase Inhibitors; 37691-11-5 / Antipain
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78. Yamagami H, Oshitani N, Suekane T, Aomatsu K, Kamata N, Sogawa M, Watanabe K, Noda E, Ikura Y, Maeda K, Hirakawa K, Arakawa T: Signet-ring cell carcinoma of the jejunum diagnosed by double balloon enteroscopy. Hepatogastroenterology; 2008 Jul-Aug;55(85):1246-8
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  • Most cases of jejunal and ileal adenocarcinoma are of well or moderately differentiated type, and other types are rare.

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  • (PMID = 18795666.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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79. Eshra A, Al-Hendal A, Al Enezi M, Al-Mishaan M, Abo Dief W: One patient, two lymphomas, three primaries. Gulf J Oncolog; 2010 Jul;(8):39-43
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  • Concomitant adenocarcinoma and non-Hodgkin's lymphoma, both located in the intestinal tract, are unusual.
  • A case of true collision tumor of a marginal zone lymphoma and a moderately differentiated adenocarcinoma of the ascending colon (hepatic flexure) is reported.
  • [MeSH-major] Adenocarcinoma / pathology. Colonic Neoplasms / pathology. Ileal Neoplasms / pathology. Lymphoma, Non-Hodgkin / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 20601338.001).
  • [ISSN] 2078-2101
  • [Journal-full-title] The Gulf journal of oncology
  • [ISO-abbreviation] Gulf J Oncolog
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Kuwait
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80. Vishnevskaia EE: [Treatment results in endometrial cancer in patients of reproductive age]. Vopr Onkol; 2006;52(4):451-4
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  • Well-differentiated cell adenocarcinoma was 3.1 times as frequent as light-cell, seroso-papillary, moderately-, low- and undifferentiated adenocarcinoma characterized by unfavorable clinical course.
  • [MeSH-minor] Adenocarcinoma / therapy. Adenocarcinoma, Clear Cell / therapy. Adult. Cystadenocarcinoma, Papillary / therapy. Cystadenocarcinoma, Serous / therapy. Female. Humans. Middle Aged. Neoplasm Staging. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 17024821.001).
  • [ISSN] 0507-3758
  • [Journal-full-title] Voprosy onkologii
  • [ISO-abbreviation] Vopr Onkol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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81. Lee YY, Yu CP, Lin CK, Nieh S, Hsu KF, Chiang H, Jin JS: Expression of survivin and cortactin in colorectal adenocarcinoma: association with clinicopathological parameters. Dis Markers; 2009;26(1):9-18
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  • [Title] Expression of survivin and cortactin in colorectal adenocarcinoma: association with clinicopathological parameters.
  • METHODS: Immunohistochemical analysis of survivin and cortactin were performed using tissue microarrays of 119 specimens from 18 well, 50 moderately, and 27 poorly differentiated colorectal adenocarcinomas and 24 colorectal adenomas with dysplasia.
  • RESULTS: The percentage of cells immunostained and the immunostaining scores for survivin and cortactin were all significantly higher in well-, moderately, and poorly differentiated colorectal adenocarcinomas than in normal colorectal epithelia.
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / metabolism. Colorectal Neoplasms / metabolism. Cortactin / metabolism. Microtubule-Associated Proteins / metabolism

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  • (PMID = 19242064.001).
  • [ISSN] 0278-0240
  • [Journal-full-title] Disease markers
  • [ISO-abbreviation] Dis. Markers
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Biomarkers, Tumor; 0 / CTTN protein, human; 0 / Cortactin; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins
  • [Other-IDs] NLM/ PMC3833605
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82. Cheng TY, Wang HP, Jan IS, Chen JH, Lin JT: Presence of intratumoral anechoic foci predicts an increased number of endoscopic ultrasound-guided fine-needle aspiration passes required for the diagnosis of pancreatic adenocarcinoma. J Gastroenterol Hepatol; 2007 Mar;22(3):315-9
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  • [Title] Presence of intratumoral anechoic foci predicts an increased number of endoscopic ultrasound-guided fine-needle aspiration passes required for the diagnosis of pancreatic adenocarcinoma.
  • An average of 4.00 FNA passes for diagnosing a well-differentiated adenocarcinoma was also significantly higher than the 2.40 diagnostic passes for a moderately differentiated adenocarcinoma and the 2.00 passes for a poorly differentiated one (P < 0.05).
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / ultrasonography. Biopsy, Fine-Needle / methods. Biopsy, Fine-Needle / statistics & numerical data. Endoscopy, Digestive System. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / ultrasonography

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  • (PMID = 17295760.001).
  • [ISSN] 0815-9319
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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83. García-Aguilar J, Hernández de Anda E, Rothenberger DA, Finne CO, Madoff RD: Endorectal ultrasound in the management of patients with malignant rectal polyps. Dis Colon Rectum; 2005 May;48(5):910-6; discussion 916-7
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  • METHODS: A retrospective review of the medical records and endorectal ultrasound images of 63 patients with endoscopically removed rectal polyps containing invasive adenocarcinoma subsequently staged by endorectal ultrasound.
  • Most tumors were well or moderately differentiated; only 3 (5 percent) were poorly differentiated.
  • [MeSH-major] Adenocarcinoma / surgery. Adenocarcinoma / ultrasonography. Endosonography. Polyps / surgery. Polyps / ultrasonography. Rectal Neoplasms / surgery. Rectal Neoplasms / ultrasonography

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  • (PMID = 15868240.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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84. Kimura H, Takamura H, Watanabe K: [A case of effective treatment with UFT/LV chemotherapy for para-aortic lymph node metastasis from colonic cancer 8 years after colectomy]. Gan To Kagaku Ryoho; 2009 Nov;36(11):1919-22
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  • Pathological examination was a moderately-differentiated adenocarcinoma with lymph node metastasis (Stage IIIa).
  • Histologically metastatic adenocarcinoma was recognized.
  • [MeSH-major] Adenocarcinoma / pathology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colonic Neoplasms / pathology. Lymphatic Metastasis

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  • (PMID = 19920401.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; Q573I9DVLP / Leucovorin
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85. Cutz JC, Guan J, Bayani J, Yoshimoto M, Xue H, Sutcliffe M, English J, Flint J, LeRiche J, Yee J, Squire JA, Gout PW, Lam S, Wang YZ: Establishment in severe combined immunodeficiency mice of subrenal capsule xenografts and transplantable tumor lines from a variety of primary human lung cancers: potential models for studying tumor progression-related changes. Clin Cancer Res; 2006 Jul 1;12(13):4043-54
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  • EXPERIMENTAL DESIGN: Using nonobese diabetic/severe combined immunodeficiency mice, subrenal capsule xenografts were generated from primary lung cancer tissue, including moderately and poorly differentiated squamous cell carcinoma, adenocarcinoma, adenosquamous carcinoma, small cell carcinoma, large cell undifferentiated carcinoma, and carcinosarcoma.


86. Seretis EC, Gavriil AN, Golematis VC, Voloudakis-Baltatzis IE: Immunoelectron study of pancreatic carcinomas using antibodies to gastrointestinal hormones. Ultrastruct Pathol; 2007 Jul-Aug;31(4):303-14
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  • The aim of this study was to investigate the ultrastructural appearance of pancreatic adenocarcinoma combined with glucagon and gastrin/cholecystokinin (CCK) expression.
  • The changes were more significant in adenocarcinoma cases.
  • Cells immunoreactive with antibodies were found in all 12 adenocarcinoma cases.
  • Moderately to poorly differentiated adenocarcinomas were poorly granulated compared with differentiated tumors.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma / ultrastructure. Antibodies, Monoclonal. Gastrointestinal Hormones / biosynthesis. Pancreatic Neoplasms / metabolism. Pancreatic Neoplasms / ultrastructure

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  • (PMID = 17786831.001).
  • [ISSN] 1521-0758
  • [Journal-full-title] Ultrastructural pathology
  • [ISO-abbreviation] Ultrastruct Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Gastrointestinal Hormones; 9007-92-5 / Glucagon; 9011-97-6 / Cholecystokinin
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87. Kouriefs C, Fazili T, Masood S, Naseem MS, Mufti GR: Incidentally detected prostate cancer in cystoprostatectomy specimens. Urol Int; 2005;75(3):213-6
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  • All incidental prostate cancers were organ confined and 91% were well or moderately differentiated.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Aged. Aged, 80 and over. Diagnosis, Differential. Disease-Free Survival. Follow-Up Studies. Humans. Incidence. Male. Middle Aged. Prostatic Intraepithelial Neoplasia / diagnosis. Retrospective Studies

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  • [Copyright] Copyright (c) 2005 S. Karger AG, Basel.
  • (PMID = 16215307.001).
  • [ISSN] 0042-1138
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Switzerland
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88. Fujita S, Yamamoto S, Akasu T, Moriya Y, Taniguchi H, Shimoda T: Quantification of CD10 mRNA in colorectal cancer and relationship between mRNA expression and liver metastasis. Anticancer Res; 2007 Sep-Oct;27(5A):3307-11
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  • TIN was higher in colon, pN1/pN2, stage III and IV, and well- or moderately-differentiated adenocarcinoma than in rectum, pNO, stage I and II, and poorly-differentiated or mucinous adenocarcinoma, respectively.
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / immunology. Adenocarcinoma / pathology. Adenocarcinoma / secondary. Female. Humans. Male. Middle Aged. Neoplasm Staging. Polymerase Chain Reaction


89. Godoy T C, Vega S J, Rivera G L: [Recurrent left lung atelectasis caused by an endobronchial metastasis of a colon cancer: report of one case]. Rev Med Chil; 2008 Feb;136(2):217-20
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  • We report an 83 year-old woman with a history of a left hemicolectomy due to tubular colon adenocarcinoma, three years ago.
  • A bronchial biopsy showed a moderately differentiated adenocarcinoma, compatible with colon adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Bronchial Neoplasms / secondary. Colonic Neoplasms / pathology. Pulmonary Atelectasis / etiology

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  • (PMID = 18483676.001).
  • [ISSN] 0034-9887
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Chile
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90. Kuroda N, Hamauzu T, Toi M, Yamaoka K, Miyazaki E, Hiroi M, Nakata H, Taguchi H, Enzan H: Pulmonary adenocarcinoma with micropapillary component: an immunohistochemical study. Case report. APMIS; 2005 Jul-Aug;113(7-8):550-4
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  • [Title] Pulmonary adenocarcinoma with micropapillary component: an immunohistochemical study. Case report.
  • The tumor showed moderately differentiated papillary adenocarcinoma with a focal micropapillary component.
  • Immunohistochemically, both the adenocarcinoma and micropapillary components were positive for cytokeratin (CK) 7, CK19, TTF (thyroid transcription factor)-1, carcinoembryonic antigen (CEA) and surfactant apoprotein A (SP-A), and negative for CK20, estrogen receptor, progesterone receptor, uroplakin III, and CA125.
  • The invasive area of the conventional adenocarcinoma component contained a large number of myofibroblasts, whereas the stroma of the micropapillary component contained a small number of myofibroblasts.
  • Myofibroblasts are present in the stroma of the invasive neoplastic nests in the micropapillary component as well as the conventional adenocarcinoma component, and D2-40 monoclonal antibody may be useful for evaluating the lymphatic invasion of pulmonary micropapillary carcinoma.
  • [MeSH-major] Adenocarcinoma, Papillary / metabolism. Adenocarcinoma, Papillary / pathology. Lung Neoplasms / metabolism. Lung Neoplasms / pathology

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  • (PMID = 16086826.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / KRT7 protein, human; 0 / Keratin-7; 0 / Nuclear Proteins; 0 / Pulmonary Surfactant-Associated Protein A; 0 / Transcription Factors; 0 / thyroid nuclear factor 1; 68238-35-7 / Keratins
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91. Elias J Jr, Semelka RC, Altun E, Tsurusaki M, Pamuklar E, Zapparoli M, Voultsinos V, Armao DM, Rubinas T: Pancreatic cancer: correlation of MR findings, clinical features, and tumor grade. J Magn Reson Imaging; 2007 Dec;26(6):1556-63
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  • PURPOSE: To assess the frequency of occurrence of poorly-marginated and focally-defined pancreatic ductal adenocarcinoma by MRI and to determine whether these appearances correlate with clinical features and histopathological grade.
  • A total of 33 patients (16 female, 17 male, mean age = 63.5 +/- 12.8, ranging from 41 to 80 years) with histopathologically-proven pancreatic ductal adenocarcinoma who underwent MR examination between August 2000 and February 2005 were retrospectively evaluated.
  • Poorly-marginated cancers exhibited well- to moderately-differentiated histopathology in 71.4% of cases, while focally-defined cancers had well- to moderately-differentiated histopathology in 17.6% of cases, P = 0.02.
  • These cancers exhibited statistically significant moderate- to well-differentiated histopathology compared to focally-defined cancers.
  • [MeSH-major] Adenocarcinoma / pathology. Magnetic Resonance Imaging / methods. Pancreatic Neoplasms / pathology

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17968967.001).
  • [ISSN] 1053-1807
  • [Journal-full-title] Journal of magnetic resonance imaging : JMRI
  • [ISO-abbreviation] J Magn Reson Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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92. Petrişor O, Giuşcă SE, Sajin M, Dobrescu G: [Ki-67 and p53 expressions versus differentiation degrees of colon adenocarcinoma]. Rev Med Chir Soc Med Nat Iasi; 2008 Jan-Mar;112(1):183-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Ki-67 and p53 expressions versus differentiation degrees of colon adenocarcinoma].
  • Our study aimed to develop semiquantitative analysis of the immunohistochemistry pattern for proliferation and apoptosis markers, as well as of their connections with the histopathology subtypes of colon adenocarcinoma.
  • MATERIAL AND METHODS: The group of study included 5 cases of well-differentiated adenocarcinoma, 5 cases of moderately differentiated adenocarcinoma and 5 cases of poor differentiated adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / chemistry. Biomarkers, Tumor / analysis. Colonic Neoplasms / chemistry. Ki-67 Antigen / analysis. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 18677924.001).
  • [ISSN] 0048-7848
  • [Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
  • [ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53; 6SO6U10H04 / Biotin; 9013-20-1 / Streptavidin
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93. Minami Y, Hasuike Y, Takeda Y, Tsujinaka T: Metachronous double cancer of the gallbladder and pancreas associated with pancreaticobiliary maljunction. J Hepatobiliary Pancreat Surg; 2008;15(3):330-3
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  • Histological examination revealed moderately differentiated ductal adenocarcinoma that had invaded to the proper muscle of the stomach.
  • [MeSH-major] Adenocarcinoma / complications. Common Bile Duct / abnormalities. Neoplasms, Second Primary / complications. Pancreatic Ducts / abnormalities. Pancreatic Neoplasms / complications

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  • (PMID = 18535774.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 9
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94. Giuliani A, Demoro M, Corona M, Di Bari M, Ricciardulli T, Galati G, Ciardi A: Synchronous colon and gastric advanced carcinomas. J Exp Clin Cancer Res; 2005 Mar;24(1):155-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • At histology, a poorly differentiated gastric adenocarcinoma with signet ring-cell component (pT2, pN0; stage IB) and a moderately differentiated colon adenocarcinoma with a tubulovillous component (pT3, pN1; stage III, Stage Dukes C) were revealed.

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  • (PMID = 15943046.001).
  • [ISSN] 0392-9078
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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95. Honda K, Natsumi Y, Sakurai K, Ishikura R, Urade M: Mucinous adenocarcinoma of the temporal region initially diagnosed as temporomandibular disorders: a case report. J Oral Pathol Med; 2006 Oct;35(9):582-5
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  • [Title] Mucinous adenocarcinoma of the temporal region initially diagnosed as temporomandibular disorders: a case report.
  • Adenocarcinoma occurring in the temporal region has not previously been reported.
  • We present a case of mucinous adenocarcinoma of the temporal region.
  • Histologic diagnosis of the biopsy showed that this mass lesion was moderately differentiated mucinous adenocarcinoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Temporomandibular Joint Disorders / diagnosis

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  • (PMID = 16968242.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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96. Yamamoto A, Ishibashi K, Tajima Y, Hatano S, Ishiguro T, Osawa T, Okada N, Kumamoto K, Yokoyama M, Haga N, Ishida H: [Successfully resected an isolated extraperitoneal metastasis of sigmoid colon cancer--a case report]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2644-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A histological examination of the tumor revealed a moderately differentiated adenocarcinoma similar to colon cancer.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Ovarian Neoplasms / secondary. Pelvic Neoplasms / secondary. Sigmoid Neoplasms / pathology. Sigmoid Neoplasms / surgery

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  • (PMID = 21224666.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
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97. Sevá-Pereira G, Trombeta VL: Early gastric cancer found at preoperative assessment for bariatric surgery. Obes Surg; 2006 Aug;16(8):1109-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The biopsy confirmed well/moderately-differentiated adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Gastric Bypass. Obesity, Morbid / complications. Stomach Neoplasms / diagnosis

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  • (PMID = 16901371.001).
  • [ISSN] 0960-8923
  • [Journal-full-title] Obesity surgery
  • [ISO-abbreviation] Obes Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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98. Milanez FM, Pereira CA, Trindade PH, Milinavicius R, Coletta EN: Lung adenocarcinoma, dermatomyositis, and Lambert-Eaton myasthenic syndrome: a rare combination. J Bras Pneumol; 2008 May;34(5):333-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lung adenocarcinoma, dermatomyositis, and Lambert-Eaton myasthenic syndrome: a rare combination.
  • Histopathology showed a moderately differentiated adenocarcinoma.
  • The overall analysis of the case and a review of the literature allow us to suggest that the clinical profile of the patient was a result of an overlap of two paraneoplastic syndromes (dermatomyositis and Lambert-Eaton myasthenic syndrome) secondary to lung adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / complications. Carcinoma, Small Cell / complications. Dermatomyositis / complications. Lambert-Eaton Myasthenic Syndrome / complications. Lung Neoplasms / complications


99. Tsai WC, Jin JS, Chang WK, Chan DC, Yeh MK, Cherng SC, Lin LF, Sheu LF, Chao YC: Association of cortactin and fascin-1 expression in gastric adenocarcinoma: correlation with clinicopathological parameters. J Histochem Cytochem; 2007 Sep;55(9):955-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association of cortactin and fascin-1 expression in gastric adenocarcinoma: correlation with clinicopathological parameters.
  • We tested the hypothesis that cortactin and fascin-1 expression correlates with clinicopathological parameters of gastric adenocarcinoma.
  • Immunohistochemical analysis of cortactin and fascin-1 was done using tissue microarrays of 100 surgical specimens, including 20 well-differentiated, 20 moderately differentiated, and 60 poorly differentiated gastric adenocarcinomas.
  • Among the 20 well-differentiated gastric adenocarcinomas, 15 cases (75%) showed negative or weak staining (1+); 5 cases (25%) had moderate (2+) or strong (3+) cortactin expression.
  • Among the 60 poorly differentiated gastric adenocarcinomas, more than three-quarters of the cases (76.7%) had moderate or strong cortactin expression; 14 cases (23.3%) had weak staining.
  • Of 20 well-differentiated gastric adenocarcinoma cases, 14 (70%) showed negative or weak staining of fascin-1, whereas nearly one-third (30%) had moderate or strong expression.
  • Among the 60 poorly differentiated gastric adenocarcinomas, 32 (53.3%) exhibited moderate or strong fascin-1 expression; fewer than half of the cases showed negative or weak staining.
  • [MeSH-major] Adenocarcinoma / metabolism. Carrier Proteins / biosynthesis. Cortactin / biosynthesis. Microfilament Proteins / biosynthesis. Stomach Neoplasms / metabolism

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  • (PMID = 17510372.001).
  • [ISSN] 0022-1554
  • [Journal-full-title] The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • [ISO-abbreviation] J. Histochem. Cytochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / Cortactin; 0 / FSCN1 protein, human; 0 / Microfilament Proteins
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100. Matsuda T, Taniguchi F, Minato H, Nomura H, Tsuda T, Aikawa I: Successful resection of advanced pancreatic tail cancer after neoadjuvant gemcitabine chemotherapy: report of a case. Surg Today; 2006;36(8):754-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Microscopically, the main tumor was confirmed as moderately differentiated tubular adenocarcinoma with interstitium and fibrosis.
  • [MeSH-major] Adenocarcinoma / therapy. Antimetabolites, Antineoplastic / therapeutic use. Deoxycytidine / analogs & derivatives. Neoadjuvant Therapy. Pancreatic Neoplasms / therapy

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  • (PMID = 16865525.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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