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1. Stewart CJ, Brennan BA, Hammond IG, Leung YC, McCartney AJ, Ruba S: Intraoperative assessment of clear cell carcinoma of the ovary. Int J Gynecol Pathol; 2008 Oct;27(4):475-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraoperative assessment of clear cell carcinoma of the ovary.
  • Our impression that primary clear cell carcinoma (CCC) causes disproportionate diagnostic difficulty led us to review the intraoperative and final histopathologic reports from a consecutive series of 44 CCC that were subject to frozen-section assessment and to compare the results with a similar number of primary serous and endometrioid carcinomas.
  • Review of the diagnostic reports showed that CCC was less frequently specifically identified than serous or endometrioid carcinomas on frozen section (44% cases compared with 55% and 65%, respectively), although the differences were not statistically significant.
  • Difficulties in distinguishing primary ovarian carcinoma from tumors metastatic to the ovary occurred in a minority of cases of all histologic subtypes, but was slightly more frequent in CCC.
  • Review of the frozen-section slides from the CCC with discrepant intraoperative diagnoses showed features suggestive or indicative of the correct diagnosis in 7 (39%) of 18 cases.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Carcinoma, Endometrioid / pathology. Carcinoma, Endometrioid / surgery. Cystadenocarcinoma, Serous / pathology. Cystadenoma, Serous / pathology. Female. Frozen Sections. Histocytochemistry. Humans. Intraoperative Care / methods. Pathology, Surgical. Retrospective Studies

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  • (PMID = 18753976.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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2. Testa D, Galli V, de Rosa G, Iovine R, Staibano S, Somma P, Mignogna C, Iengo M: Clinical and prognostic aspects of laryngeal clear cell carcinoma. J Laryngol Otol; 2005 Dec;119(12):991-4
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  • [Title] Clinical and prognostic aspects of laryngeal clear cell carcinoma.
  • Clear cell carcinoma (CCC) of the larynx is a rare pathological finding; only eight cases are described in the literature.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Laryngeal Neoplasms / pathology

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  • (PMID = 16354366.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 18
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3. Ivanov SV, Ivanova AV, Salnikow K, Timofeeva O, Subramaniam M, Lerman MI: Two novel VHL targets, TGFBI (BIGH3) and its transactivator KLF10, are up-regulated in renal clear cell carcinoma and other tumors. Biochem Biophys Res Commun; 2008 Jun 13;370(4):536-40
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  • [Title] Two novel VHL targets, TGFBI (BIGH3) and its transactivator KLF10, are up-regulated in renal clear cell carcinoma and other tumors.
  • The inability of the mutant VHL protein to destabilize HIF-1 plays a crucial role in malignant angiogenesis.
  • We used expression arrays and cell lines with different VHL status to identify ECM-associated genes controlled by VHL.
  • Analyzing the mechanism of TGFBI up-regulation in clear cell carcinoma, we identified a novel VHL target, a Kruppel-like transcriptional factor 10 (KLF10).

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  • (PMID = 18359287.001).
  • [ISSN] 1090-2104
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / / Z01 BC008579-14; United States / NCI NIH HHS / CO / N01-CO-56000
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Early Growth Response Transcription Factors; 0 / Extracellular Matrix Proteins; 0 / KLF10 protein, human; 0 / Kruppel-Like Transcription Factors; 0 / Transforming Growth Factor beta; 148710-76-3 / betaIG-H3 protein; EC 6.3.2.19 / VHL protein, human; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
  • [Other-IDs] NLM/ NIHMS51643; NLM/ PMC2413015
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4. Tillou X, Demailly M, Hakami F, Westeel PF, Saint F, Petit J: De novo renal carcinoma in renal transplant recipients: effect of early treatment. Transplant Proc; 2009 Oct;41(8):3314-6
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  • [Title] De novo renal carcinoma in renal transplant recipients: effect of early treatment.
  • OBJECTIVE: To evaluate the epidemiology, diagnosis, and outcome of de novo renal cell carcinoma in renal transplant recipients.
  • Incidence, diagnosis, histologic type, treatment, and outcome were analyzed in all patients.
  • RESULTS: Thirty-three patients underwent nephrectomy because of suspect renal lesions including 22 de novo tumors in 21 native kidneys (renal clear-cell carcinoma in 15 and papillary carcinoma in 7).
  • Mean (range) time after diagnosis was 25.6 (2.3-105.5) months.
  • Only 1 patient died, at 8 months after diagnosis.
  • In our patients, 65% of patients had malignant lesions.
  • [MeSH-major] Carcinoma, Renal Cell / epidemiology. Kidney Neoplasms / epidemiology. Kidney Transplantation / adverse effects
  • [MeSH-minor] Abdomen / ultrasonography. Adult. Aged. Carcinoma, Papillary / epidemiology. Carcinoma, Papillary / pathology. Carcinoma, Papillary / surgery. Humans. Incidence. Middle Aged. Nephrectomy. Prognosis. Retrospective Studies. Risk Factors. Tomography, X-Ray Computed

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  • (PMID = 19857739.001).
  • [ISSN] 1873-2623
  • [Journal-full-title] Transplantation proceedings
  • [ISO-abbreviation] Transplant. Proc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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5. Tan DS, Kaye S: Ovarian clear cell adenocarcinoma: a continuing enigma. J Clin Pathol; 2007 Apr;60(4):355-60
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  • [Title] Ovarian clear cell adenocarcinoma: a continuing enigma.
  • Ovarian clear cell adenocarcinomas (OCCAs) account for <5% of all ovarian malignancies.
  • By contrast, early-stage clear cell ovarian cancer carries a relatively good prognosis.
  • Marked similarities with clear cell carcinomas of the kidney and endometrium have been noted by some investigators, raising interesting possibilities regarding novel therapeutic approaches.
  • [MeSH-major] Adenocarcinoma, Clear Cell / etiology. Ovarian Neoplasms / etiology
  • [MeSH-minor] Disease Progression. Drug Resistance, Neoplasm. Female. Genetic Predisposition to Disease. Humans. Prognosis

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  • (PMID = 17018684.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 83
  • [Other-IDs] NLM/ PMC2001101
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6. Hartmann A, Junker K, Dietmaier W, Schröder S, Lopez D, Hofstädter F, Blaszyk H: Molecular evidence for progression of nephrogenic metaplasia of the urinary bladder to clear cell adenocarcinoma. Hum Pathol; 2006 Jan;37(1):117-20
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  • [Title] Molecular evidence for progression of nephrogenic metaplasia of the urinary bladder to clear cell adenocarcinoma.
  • Previous case reports suggest the possibility of nephrogenic metaplasia progressing to clear cell adenocarcinoma, but a malignant potential of nephrogenic metaplasia is generally not acknowledged.
  • A case of a 70-year-old female patient with multiple recurrences of nephrogenic metaplasia of the urinary bladder and subsequent development of clear cell adenocarcinoma is described.
  • Results of molecular studies, particularly comparative genomic hybridization analysis, suggest clonal evolution of nephrogenic metaplasia to clear cell adenocarcinoma in this case.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Adenoma / pathology. Precancerous Conditions / pathology. Urinary Bladder / pathology. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Clone Cells. Cystectomy. DNA, Neoplasm / analysis. Disease Progression. Disease-Free Survival. Female. Humans. Loss of Heterozygosity. Metaplasia / genetics. Metaplasia / metabolism. Metaplasia / pathology. Neoplasm Recurrence, Local. Nucleic Acid Hybridization. Urethra / surgery

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  • (PMID = 16360424.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm
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7. Thompson RH, Dong H, Kwon ED: Implications of B7-H1 expression in clear cell carcinoma of the kidney for prognostication and therapy. Clin Cancer Res; 2007 Jan 15;13(2 Pt 2):709s-715s
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  • [Title] Implications of B7-H1 expression in clear cell carcinoma of the kidney for prognostication and therapy.
  • B7-H1 encompasses a recently discovered cell surface glycoprotein within the B7 family of T-cell co-regulatory molecules.
  • Tumor-associated B7-H1, as well as B7-H1 on activated lymphocytes, has been shown to impair antigen-specific T-cell function and survival in vitro.
  • Our group has recently reported that B7-H1 is aberrantly expressed in both primary and metastatic renal cell carcinoma (RCC) as revealed via immunohistochemical staining of both fresh-frozen and paraffin-embedded nephrectomy specimens.
  • In addition, we have shown that B7-H1 expression by clear cell RCC tumors (or infiltrating mononuclear cells) correlates with aggressive pathologic features, including advanced tumor-node-metastasis stage, tumor size, higher nuclear grade, and coagulative necrosis.
  • In one study of 306 patients, with a median clinical follow-up of 11 years, we reported that RCC B7-H1 expression correlates with increased risk of disease progression, cancer-specific death, and overall mortality even after multivariate adjustment.
  • Such associations may relate to the recognized ability of B7-H1 to inhibit T-cell-mediated antitumoral immunity.
  • [MeSH-minor] Animals. Antigens, CD274. Antigens, Neoplasm / metabolism. Carcinoma, Renal Cell / metabolism. Carcinoma, Renal Cell / pathology. Disease Models, Animal. Humans. Immunotherapy / methods. Kidney Neoplasms / metabolism. Kidney Neoplasms / pathology. Mice. Neoplasm Metastasis. Prognosis. T-Lymphocytes / metabolism. Time Factors

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  • (PMID = 17255298.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD274; 0 / Antigens, Neoplasm; 0 / CD274 protein, human
  • [Number-of-references] 42
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8. Seko A, Kataoka F, Aoki D, Sakamoto M, Nakamura T, Hatae M, Yonezawa S, Yamashita K: N-Acetylglucosamine 6-O-sulfotransferase-2 as a tumor marker for uterine cervical and corpus cancer. Glycoconj J; 2009 Nov;26(8):1065-73
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  • N-Acetylglucosamine 6-O-sulfotransferase-2 (GlcNAc6ST2) is ectopically expressed in ovarian mucinous and clear cell adenocarcinoma [Kanoh et al., Glycoconj J 23:453-460, 2006].


9. Komiyama S, Nakamura M, Murakami I, Kuwabara Y, Kurahashi T, Tanaka K, Mikami M: A heavily pretreated patient with recurrent clear cell adenocarcinoma of the ovary in whom carcinomatous peritonitis was controlled successfully by salvage therapy with gemcitabine. Arch Gynecol Obstet; 2008 Dec;278(6):565-8
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  • [Title] A heavily pretreated patient with recurrent clear cell adenocarcinoma of the ovary in whom carcinomatous peritonitis was controlled successfully by salvage therapy with gemcitabine.
  • INTRODUCTION: Advanced clear cell adenocarcinoma of the ovary is a histologic type with an extremely poor prognosis.
  • No reports have been published concerning useful drugs for salvage chemotherapy for this type of cancer.
  • We performed salvage therapy with gemcitabine in a patient with multiple-drug- resistant, unresectable recurrent clear cell adenocarcinoma of the ovary and succeeded in stabilizing recurrent lesions and controlling carcinomatous peritonitis.
  • CASE REPORT: A 55-year-old woman was in Stage IIIc of clear cell adenocarcinoma of the ovary.
  • After three courses of fourth-line chemotherapy with gemcitabine for the treatment of carcinomatous peritonitis and hepatic and splenic metastatic lesions, serum CA-125 and the severity of ascites showed marked decreases, and its efficacy for the hepatic and splenic metastatic lesions was classified as 5-month stable disease.
  • CONCLUSION: Gemcitabine is also useful for heavily pretreated clear cell adenocarcinoma of the ovary.
  • [MeSH-major] Adenocarcinoma, Clear Cell / drug therapy. Antimetabolites, Antineoplastic / therapeutic use. Deoxycytidine / analogs & derivatives. Neoplasm Recurrence, Local / drug therapy. Ovarian Neoplasms / drug therapy. Peritonitis / drug therapy. Salvage Therapy / methods

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  • [ErratumIn] Arch Gynecol Obstet. 2009 Feb;279(2):271. Komiyama, Shin [corrected to Komiyama, Shin-ichi]
  • (PMID = 17576588.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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10. Kato N, Toukairin M, Asanuma I, Motoyama T: Immunocytochemistry for hepatocyte nuclear factor-1beta (HNF-1beta): a marker for ovarian clear cell carcinoma. Diagn Cytopathol; 2007 Apr;35(4):193-7
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  • [Title] Immunocytochemistry for hepatocyte nuclear factor-1beta (HNF-1beta): a marker for ovarian clear cell carcinoma.
  • Recent microarray studies have shown that the expression of hepatocyte nuclear factor-1beta (HNF-1beta) was significantly up-regulated in clear cell carcinoma (CCC) of the ovary.
  • We designed an experimental study using three CCC cell lines to evaluate the influence of alcohol fixation or air drying on immunocytochemistry for HNF-1beta.
  • Each cell line was cultured on chamber slides or transplanted into the abdominal cavity of nude mice, then the slides or ascites smears of nude mice were immunostained with or without microwave-mediated epitope retrieval.
  • In contrast, two serous adenocarcinoma cell lines never showed immunoreactivity.
  • Based on these results, 21 archival Papanicolaou-stained slides of peritoneal fluid (5 CCCs, 12 serous, 2 mucinous, and 2 endometrioid adenocarcinomas) were decolorized and immunostained under heating pretreatment.
  • HNF-1beta is likely to be helpful for the diagnosis of CCC in the peritoneal fluid.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Biomarkers, Tumor / analysis. Hepatocyte Nuclear Factor 1-beta / metabolism. Immunohistochemistry / methods. Ovarian Neoplasms / diagnosis
  • [MeSH-minor] Alcohols. Animals. Cell Line, Tumor. Female. Fixatives. Heating. Humans. Mice. Microwaves. Papanicolaou Test. Tissue Fixation / methods. Vaginal Smears

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17351940.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Alcohols; 0 / Biomarkers, Tumor; 0 / Fixatives; 138674-15-4 / Hepatocyte Nuclear Factor 1-beta
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11. Fadare O, Liang SX, Ulukus EC, Chambers SK, Zheng W: Precursors of endometrial clear cell carcinoma. Am J Surg Pathol; 2006 Dec;30(12):1519-30
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  • [Title] Precursors of endometrial clear cell carcinoma.
  • In contrast to uterine endometrioid and serous carcinomas, very little is known about the potential precursor lesions of endometrial clear cell carcinoma (ECCC).
  • In our routine practice, we have noted the presence of a spectrum of atypical glandular changes in the endometria adjacent to ECCC or endometrial carcinomas with a clear cell component, which on the basis of current criteria, would not qualify for any specific designation.
  • Thirty archived cases of pure ECCC (n=14) or mixed endometrial carcinomas with a >10% clear cell component (n=16) were retrieved and the "normal" endometria adjacent to the malignancies were evaluated in detail.
  • Thirty-eight benign uteri and 30 uteri with classic endometrial endometrioid carcinoma (EEC) served as controls.
  • In contrast, PPL were identified neither in the benign uteri nor in endometrioid carcinoma control groups (P<0.001).
  • ER/progesterone receptor indices for benign endometria, PPL, and carcinoma were 90/80, 21.52/4.61, and 11/4, respectively.
  • The PPL described herein have a morphologic and immunophenotypic profile which seems to be distinct from both the benign endometria in which they reside and the adjacent areas of ECCC.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Endometrial Neoplasms / pathology. Precancerous Conditions / pathology

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  • (PMID = 17122507.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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12. Yokota N, Koizume S, Miyagi E, Hirahara F, Nakamura Y, Kikuchi K, Ruf W, Sakuma Y, Tsuchiya E, Miyagi Y: Self-production of tissue factor-coagulation factor VII complex by ovarian cancer cells. Br J Cancer; 2009 Dec 15;101(12):2023-9
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  • RESULTS: Ectopic fVII expression occurs frequently in ovarian cancers, particularly in clear cell carcinoma.
  • We further showed that ovarian cancer cells express TF-fVIIa on the cell surface under normoxia and that this procoagulant activity is enhanced by hypoxic stimuli.
  • CONCLUSION: These results raise the possibility that cancer cell-derived TF-fVIIa could cause thrombotic events in ovarian cancer patients.
  • [MeSH-minor] Cell Hypoxia. Cell Line, Tumor. Cell-Derived Microparticles / secretion. Female. Humans. Neoplasms, Glandular and Epithelial / chemistry

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  • (PMID = 19904262.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL060742
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 9001-25-6 / Factor VII; 9035-58-9 / Thromboplastin
  • [Other-IDs] NLM/ PMC2795428
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13. Pouessel D, Culine S: Targeted therapies in metastatic renal cell carcinoma: the light at the end of the tunnel. Expert Rev Anticancer Ther; 2006 Dec;6(12):1761-7
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  • [Title] Targeted therapies in metastatic renal cell carcinoma: the light at the end of the tunnel.
  • The year 2006 will mark a turning point in the daily management of patients with metastatic renal cell carcinoma.
  • The growing understanding of molecular mechanisms involved in the pathogenesis of the disease, especially clear-cell carcinoma, has led to the development of multiple targeted therapies with significant clinical benefits.
  • Further studies are needed to determine the optimal combinations of these agents in metastatic disease and to assess their impact in the adjuvant setting.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Carcinoma, Renal Cell / secondary. Kidney Neoplasms / therapy

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  • (PMID = 17181490.001).
  • [ISSN] 1744-8328
  • [Journal-full-title] Expert review of anticancer therapy
  • [ISO-abbreviation] Expert Rev Anticancer Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; 0 / Benzenesulfonates; 0 / Immunologic Factors; 0 / Indoles; 0 / Interferon-alpha; 0 / Interleukin-2; 0 / Neoplasm Proteins; 0 / Phenylurea Compounds; 0 / Protein Kinase Inhibitors; 0 / Pyridines; 0 / Pyrroles; 0 / sunitinib; 25X51I8RD4 / Niacinamide; 2S9ZZM9Q9V / Bevacizumab; 624KN6GM2T / temsirolimus; 9ZOQ3TZI87 / sorafenib; EC 2.7.- / Protein Kinases; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.10.1 / Receptors, Vascular Endothelial Growth Factor; W36ZG6FT64 / Sirolimus
  • [Number-of-references] 42
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14. Stolnicu S, Borda A, Radulescu D, Puscasiu L, Berger N, Nogales FF: Metastasis from papillary renal cell carcinoma masquerading as primary ovarian clear cell tumor. Pathol Res Pract; 2007;203(11):819-22
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  • [Title] Metastasis from papillary renal cell carcinoma masquerading as primary ovarian clear cell tumor.
  • Microscopic examination disclosed cystic spaces lined by abundant clear and eosinophilic tumor cells with pleomorphic nuclei.
  • Differential diagnosis included primary ovarian oxyphilic-type clear cell carcinoma and sex-cord tumor with extensive luteinization.
  • However, analysis of the patient's past history revealed that in 2003, she had undergone nephrectomy for a papillary renal cell carcinoma, and a histological comparison between the primary and the present tumor exhibited in the latter a substantially larger number of clear cells and loss of papillary architecture.
  • Immunohistochemistry demonstrated a characteristic renal immunophenotype for a type II tubulopapillary tumor metastatic to ovary.
  • This is the first reported case of ovarian metastases of type II tubulopapillary carcinoma of the kidney.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Carcinoma, Renal Cell / secondary. Kidney Neoplasms / pathology. Ovarian Neoplasms / secondary
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Neprilysin / metabolism. Racemases and Epimerases / metabolism


15. Lee S, Garner EI, Welch WR, Berkowitz RS, Mok SC: Over-expression of hypoxia-inducible factor 1 alpha in ovarian clear cell carcinoma. Gynecol Oncol; 2007 Aug;106(2):311-7
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  • [Title] Over-expression of hypoxia-inducible factor 1 alpha in ovarian clear cell carcinoma.
  • OBJECTIVE: Unlike other histological types of epithelial ovarian carcinoma, ovarian clear cell carcinoma is known to have very poor response to therapy even when discovered in its early stages.
  • Since tumor hypoxia has been shown to be strongly associated with poor prognosis, deregulation of the representative factor of tissue hypoxia; hypoxia-inducible factor 1 alpha (HIF-1alpha) and related protein; Von Hippel-Lindau (VHL) may be associated with poor prognosis of ovarian clear cell carcinoma.
  • METHODS: Immunolocalization of both HIF-1alpha and VHL was performed on 56 cases of paraffin-embedded tissue sections of four different histological types of epithelial ovarian carcinoma and 5 cases of benign ovarian tumors as a control.
  • Quantitative RT-PCR analysis of both HIF1A and VHL was performed on RNA isolated from 61 microdissected frozen tissues of four different histological types of epithelial ovarian carcinoma and 6 cases of normal ovarian epithelial cells.
  • RESULTS: HIF-1alpha expression levels were significantly higher in ovarian clear cell carcinoma than in other histological types (P=0.001).
  • We found no correlation between mRNA and protein expression level in any type of carcinoma specimens.
  • Among endometrioid, serous, and mucinous carcinoma, there were no differences in HIF-1alpha expression (P=0.643).
  • There was a negative correlation between HIF-1alpha and VHL in serous (r=-0.661, P=0.027) and in endometrioid carcinoma (r=-0.657 P=0.039), but no correlation was found between HIF-1alpha and VHL expression levels in ovarian clear cell carcinoma (P=0.60).
  • CONCLUSIONS: The results suggest that the role of hypoxia may change according to the histological type of ovarian carcinoma.
  • High expression of HIF-1alpha and its independence from VHL in ovarian clear cell carcinoma may confer chemoresistance in this histological type.

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  • (PMID = 17532031.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R33 CA103595; United States / NCI NIH HHS / CA / R33 CA103595-04; United States / NCI NIH HHS / CA / CA103595-04; United States / NCI NIH HHS / CA / CA105009-030002; United States / NCI NIH HHS / CA / P50 CA105009; United States / NCI NIH HHS / CA / P50 CA105009-030002; United States / PHS HHS / / P50105009; United States / NCI NIH HHS / CA / R01 CA133057; United States / NCI NIH HHS / CA / R33CA103595
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / RNA, Messenger; EC 6.3.2.19 / VHL protein, human; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
  • [Other-IDs] NLM/ NIHMS28316; NLM/ PMC1995602
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16. Kinoshita T, Inoue H, Kinouchi T, Kobayashi M, Takada T, Hara T, Hatano K, Nonomura N: Preoperative induction with sorafenib pathologically downstaged advanced renal cell carcinoma: a case report. Int J Urol; 2010 Mar;17(3):286-8
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  • [Title] Preoperative induction with sorafenib pathologically downstaged advanced renal cell carcinoma: a case report.
  • We present the case of a patient with renal cell carcinoma treated preoperatively with sorafenib.
  • Complete resection of the left renal mass measuring 7.2 x 6.6 cm seemed to be difficult at diagnosis because of large renal hilar lymph nodes.
  • Pathological findings revealed that over 90% of the renal tumor was substituted by necrotic fibrotic tissue and that the residual neoplastic component was diagnosed as clear cell carcinoma.
  • At 6 months after radical nephrectomy, a new computed tomography scan revealed no evidence of disease with the disappearance of lung nodules.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Benzenesulfonates / administration & dosage. Carcinoma, Renal Cell / drug therapy. Carcinoma, Renal Cell / surgery. Kidney Neoplasms / drug therapy. Kidney Neoplasms / surgery. Pyridines / administration & dosage

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  • (PMID = 20409221.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzenesulfonates; 0 / Phenylurea Compounds; 0 / Pyridines; 25X51I8RD4 / Niacinamide; 9ZOQ3TZI87 / sorafenib
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17. Castellvi J, Garcia A, de la Torre J, Hernandez J, Gil A, Xercavins J, Ramón y Cajal S: Ephrin B expression in epithelial ovarian neoplasms correlates with tumor differentiation and angiogenesis. Hum Pathol; 2006 Jul;37(7):883-9
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  • Differential gene expression studies are identifying new sets of genes with a role in the classification, differential diagnosis, and prognosis of some human tumors.
  • Ephrin B1, a factor involved in angiogenesis, has been shown to be up-regulated in ovarian carcinomas, making it a potential target for cancer treatment.
  • Specimens from 112 benign, borderline, and malignant epithelial ovarian tumors were examined.
  • Ephrin B was detected in 50% of ovarian tumors: clear cell carcinomas (93%), serous carcinomas (74%), mucinous carcinomas (29%), and endometrioid carcinomas (27%).
  • High-grade carcinomas showed greatest ephrin B expression, whereas benign tumors and low-grade carcinomas were rarely positive.
  • A correlation was found between ephrin B expression and microvessel density, supporting the angiogenic role of this factor in ovarian carcinomas.
  • Ephrin B expression was associated with higher rates of disease recurrence and a decrease in overall survival.
  • A distinctive pattern of ephrin B expression was observed in ovarian tumors: high-grade tumors and clear cell and serous carcinomas show higher expression, correlating with the aggressiveness.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Blotting, Western. Cell Differentiation. Female. Humans. Immunohistochemistry. Microcirculation. Middle Aged. Survival Analysis

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  • (PMID = 16784989.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ephrin-B1
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18. Veras E, Mao TL, Ayhan A, Ueda S, Lai H, Hayran M, Shih IeM, Kurman RJ: Cystic and adenofibromatous clear cell carcinomas of the ovary: distinctive tumors that differ in their pathogenesis and behavior: a clinicopathologic analysis of 122 cases. Am J Surg Pathol; 2009 Jun;33(6):844-53
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  • [Title] Cystic and adenofibromatous clear cell carcinomas of the ovary: distinctive tumors that differ in their pathogenesis and behavior: a clinicopathologic analysis of 122 cases.
  • Ovarian clear cell carcinomas (CCC) typically present as large adnexal, stage I tumors and are generally considered highly malignant.
  • They are frequently associated with endometriosis and, less often with clear cell adenofibromas.
  • Various features were analyzed including: age, race, laterality, tumor size, architectural pattern (papillary, tubulo-cystic, solid, mixed patterns), grade, mitotic index, association with endometriosis including atypical endometriosis/intraepithelial carcinoma, stage and survival.
  • Both the cystic and adenofibromatous CCC forms were associated with endometriosis and atypical endometriosis/intraepithelial carcinoma, but the frequency was much higher in the cystic group.
  • Specifically, endometriosis was found in 91% of cystic CCCs and atypical endometriosis/intraepithelial carcinoma in 62% of these cases, whereas endometriosis was found in 44% of adenofibromatous CCCs and atypical endometriosis/intraepithelial carcinoma in 11% of cases.
  • A predominantly papillary pattern was seen in 47% of cystic CCCs, whereas none of the adenofibromatous carcinomas displayed a predominantly papillary pattern.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Adenofibroma / pathology. Cysts / pathology. Ovarian Neoplasms / pathology

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  • (PMID = 19342944.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Rotellini M, Fondi C, Paglierani M, Stomaci N, Raspollini MR: Clear cell carcinoma of the bladder in a patient with a earlier clear cell renal cell carcinoma: a case report with morphologic, immunohistochemical, and cytogenetical analysis. Appl Immunohistochem Mol Morphol; 2010 Jul;18(4):396-9
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  • [Title] Clear cell carcinoma of the bladder in a patient with a earlier clear cell renal cell carcinoma: a case report with morphologic, immunohistochemical, and cytogenetical analysis.
  • Clear cell transitional carcinoma of the bladder is a subtype of transitional carcinoma that morphologically resembles a clear cell renal cell carcinoma.
  • Although kidney tumors do not frequently metastasize to the bladder, the recurrence after a clear cell renal cell carcinoma has been reported even several years after nephrectomy.
  • We report the case of a male patient to whom radical nephrectomy for a clear cell renal cell carcinoma has been done, with a bladder tumor featuring polygonal cells with abundant clear cytoplasm deeply infiltrating the vesical wall.
  • We discuss the morphologic features, the immunohistochemical staining with a new marker and the UroVysion FISH analysis to achieve a definitive diagnosis.

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  • (PMID = 20216403.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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20. Takano M, Sugiyama T, Yaegashi N, Suzuki M, Tsuda H, Sagae S, Udagawa Y, Kuzuya K, Kigawa J, Takeuchi S, Tsuda H, Moriya T, Kikuchi Y: Progression-free survival and overall survival of patients with clear cell carcinoma of the ovary treated with paclitaxel-carboplatin or irinotecan-cisplatin: retrospective analysis. Int J Clin Oncol; 2007 Aug;12(4):256-60
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  • [Title] Progression-free survival and overall survival of patients with clear cell carcinoma of the ovary treated with paclitaxel-carboplatin or irinotecan-cisplatin: retrospective analysis.
  • BACKGROUND: Irinotecan hydrochloride, a topoisomerase I inhibitor, has been preliminarily recognized as an effective agent against clear cell carcinoma of the ovary (CCC), but there are few clinical data.
  • METHODS: One hundred and seventeen patients at International Federation of Gynecology and Obstetrics (FIGO) stages Ic (ascites/malignant washing) - IV were identified by scanning the medical records of ten Japanese hospitals.
  • [MeSH-major] Adenocarcinoma, Clear Cell / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Camptothecin / analogs & derivatives. Carboplatin / therapeutic use. Cisplatin / therapeutic use. Ovarian Neoplasms / drug therapy. Paclitaxel / therapeutic use
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Disease-Free Survival. Female. Humans. Middle Aged. Retrospective Studies. Survival Analysis

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  • (PMID = 17701003.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0H43101T0J / irinotecan; BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin; XT3Z54Z28A / Camptothecin
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21. Yetkin G, Uludağ M, Ozağari A: Solitary colonic metastasis of renal cell carcinoma. Acta Chir Belg; 2008 Mar-Apr;108(2):264-5
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  • [Title] Solitary colonic metastasis of renal cell carcinoma.
  • We report a rare case of a solitary metastasis of a renal cell carcinoma which manifested as a primary colonic tumour.
  • A 60-year-old male patient who had undergone a right radical nephrectomy 5 years previously for renal cell carcinoma, presented with a history of dyspepsia and pain in the right upper abdomen.
  • Postoperative histological examination revealed that the tumour was a metastatic renal cell carcinoma of the clear cell type.
  • [MeSH-major] Carcinoma, Renal Cell / secondary. Colonic Neoplasms / secondary. Kidney Neoplasms / pathology

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  • (PMID = 18557158.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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22. Picken MM: The evolving concept of renal neoplasia: impact of emerging molecular and electron microscopic studies. Ultrastruct Pathol; 2005 May-Aug;29(3-4):277-82
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  • The classification of renal tumors has evolved from one that initially encompassed only 2 types of tumors, i.e., clear and granular cell carcinomas, to the markedly expanded recent classification that incorporates new entities, some of which are primarily defined by specific molecular abnormalities.
  • Despite these advances, a single tumor category, clear cell carcinoma, still incorporates the majority (approximately 70%) of renal tumors.
  • Electron microscopic studies have been pivotal in defining the spectrum of oncocytoma-chromophobe renal cell carcinoma.
  • Cytoplasmic eosinophilia found in some renal cell carcinomas currently classified as clear cell type is under intense study.
  • Tumors that have recently emerged from this group include tumors with translocations involving chromosome Xp11.2, carcinomas associated with neuroblastoma and epithelioid angiomyolipoma.
  • The author concludes that although the routine application of electron microscopy to kidney tumor diagnosis may not be practical, systematic ultrastructural studies of these tumors may aid in the definition of new entities.

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  • (PMID = 16036881.001).
  • [ISSN] 0191-3123
  • [Journal-full-title] Ultrastructural pathology
  • [ISO-abbreviation] Ultrastruct Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 33
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23. Verine J, Lehmann-Che J, Soliman H, Feugeas JP, Vidal JS, Mongiat-Artus P, Belhadj S, Philippe J, Lesage M, Wittmer E, Chanel S, Couvelard A, Ferlicot S, Rioux-Leclercq N, Vignaud JM, Janin A, Germain S: Determination of angptl4 mRNA as a diagnostic marker of primary and metastatic clear cell renal-cell carcinoma. PLoS One; 2010;5(4):e10421
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  • [Title] Determination of angptl4 mRNA as a diagnostic marker of primary and metastatic clear cell renal-cell carcinoma.
  • BACKGROUND: We have previously shown that angiopoietin-like 4 (angptl4) mRNA, a hypoxia-inducible gene, is highly expressed in clear cell renal-cell carcinoma (ccRCC), the most common subtype of RCC for which no specific marker is available.
  • In contrast, angptl4 mRNA was neither expressed in 94% non-ccRCC renal tumors (papillary RCCs (n = 46), chromophobe RCCs (n = 28), and oncocytomas (n = 9)), nor in non-renal clear cell carcinomas (n = 39).
  • Angptl4 expression was also examined in tumors associated (n = 23) or not associated (n = 66) with VHL disease.
  • CONCLUSIONS/SIGNIFICANCE: Angptl4 mRNA expression was highly associated with ccRCC (p = 1.5 10(-49), Chi square test) allowing to define its expression as a diagnosis marker for primary ccRCC.
  • Moreover, angptl4 mRNA allows to discriminate the renal origin of metastases of clear-cell carcinomas arising from various organs.
  • [MeSH-major] Angiopoietins / genetics. Carcinoma, Renal Cell / diagnosis. Molecular Diagnostic Techniques. RNA, Messenger / analysis
  • [MeSH-minor] Biomarkers. Diagnosis, Differential. Humans. In Situ Hybridization. Neoplasm Metastasis. RNA, Neoplasm / analysis. Retrospective Studies

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  • (PMID = 20454689.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ANGPTL4 protein, human; 0 / Angiopoietins; 0 / Biomarkers; 0 / RNA, Messenger; 0 / RNA, Neoplasm
  • [Other-IDs] NLM/ PMC2861680
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24. Kato N, Sasou S, Motoyama T: Expression of hepatocyte nuclear factor-1beta (HNF-1beta) in clear cell tumors and endometriosis of the ovary. Mod Pathol; 2006 Jan;19(1):83-9
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  • [Title] Expression of hepatocyte nuclear factor-1beta (HNF-1beta) in clear cell tumors and endometriosis of the ovary.
  • Clear cell tumors of the ovary are frequently associated with ovarian endometriosis.
  • Clinicopathologically, it has been suggested that clear cell tumors develop from endometriosis, but there has been little molecular evidence supporting this speculation.
  • Microarray analysis revealed recently that hepatocyte nuclear factor-1beta (HNF-1beta) was significantly upregulated in clear cell carcinoma of the ovary.
  • In the present study, we examined 30 clear cell tumors (26 malignant, three borderline, and one benign) and 40 endometriotic cysts to clarify if differentiation into the clear cell lineage already begins in ovarian endometriosis.
  • All of the 30 clear cell tumors, including borderline and benign ones, showed immunohistochemical expression of HNF-1beta in the nucleus, while other types of ovarian epithelial tumors (endometrioid, serous, mucinous, and Brenner tumors) rarely expressed it.
  • Among 30 clear cell tumors, 17 (56%) cases were associated with endometriosis, and endometriotic epithelium was identified in 12 cases.
  • In nine of the 12 cases, distinct nuclear immunostaining for HNF-1beta was detected in the endometriotic epithelium, as well as in the clear cell tumor.
  • Our results indicate that HNF-1beta is an excellent molecular marker for ovarian clear cell tumors, including benign, borderline and malignant lesions.
  • Early differentiation into the clear cell lineage takes place in ovarian endometriosis, not only in atypical endometriosis, but also in endometriosis with degenerative and regenerative changes, and this is probably responsible for the frequent occurrence of clear cell carcinoma in ovarian endometriosis.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Endometriosis / pathology. Hepatocyte Nuclear Factor 1-beta / biosynthesis. Ovarian Diseases / pathology. Ovarian Neoplasms / pathology

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  • (PMID = 16258507.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 138674-15-4 / Hepatocyte Nuclear Factor 1-beta
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25. Bagley CA, Bookland MJ, Pindrik JA, Ozmen T, Gokaslan ZL, Wolinsky JP, Witham TF: Fractionated, single-port radiotherapy delays paresis in a metastatic spinal tumor model in rats. J Neurosurg Spine; 2007 Sep;7(3):323-7
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  • OBJECT: Spinal column metastatic disease affects thousands of cancer patients every year.
  • Despite the enormous clinical impact of spinal column metastatic disease, the literature currently lacks an accurate animal model for testing the efficacy of irradiation on spinal column metastases.
  • A 2- to 3-mm-diameter bur hole was drilled for the implantation of a section of CRL-1666 breast adenocarcinoma.
  • CONCLUSIONS: These findings demonstrate the efficacy of focal spinal irradiation in delaying the onset of paralysis in a rat metastatic spine tumor model, but without a clear survival benefit.
  • This finding parallels the observed clinical course of spinal column metastatic disease in humans and provides a basis for the future comparison of novel local and systemic treatments to augment the observed effects of focal irradiation.
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Animals. Breast Neoplasms / pathology. Cell Line, Tumor. Disease Models, Animal. Dose Fractionation. Female. Neoplasm Transplantation. Rats. Rats, Inbred F344. Survival Analysis

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  • (PMID = 17877267.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Vaidya AP, Horowitz NS, Oliva E, Halpern EF, Duska LR: Uterine malignant mixed mullerian tumors should not be included in studies of endometrial carcinoma. Gynecol Oncol; 2006 Nov;103(2):684-7
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  • [Title] Uterine malignant mixed mullerian tumors should not be included in studies of endometrial carcinoma.
  • OBJECTIVE: Uterine mixed malignant mullerian tumors (MMMT) have traditionally been excluded from clinical trials of endometrial cancer because of a belief that they are more correctly included in the sarcoma category.
  • The current study was undertaken to compare outcomes, stage for stage, of uterine MMMT with poor prognosis endometrial adenocarcinomas.
  • Cases were matched by age, stage, performance status, and surgical procedure to controls consisting of grade 3 endometrioid, papillary serous, and clear cell endometrial carcinomas from the same time period.
  • Approximately half of the patients (53%) had stage III or IV disease.
  • Of the controls, 31 (69%) had grade 3 endometrioid, 11 (24%) papillary serous, and 3 (7%) clear cell carcinoma.
  • Patients with early stage disease (stage I or II) had shorter median survival than controls, 26 months (range 3-7) vs. 95 months (range 4-123) (P = 0.003).
  • There was no difference in median survival when comparing advanced disease (stage III or IV) to matched controls, 15 months (range 0.5-70) vs. 19 months (range 0.5-100) (P = NS).
  • CONCLUSIONS: Patients with uterine MMMT have a poorer prognosis than those patients with high grade epithelial tumors, especially for those with early stage disease.
  • Given the discrepancy in survival, these patients should not be included in studies of endometrial carcinoma.
  • [MeSH-minor] Carcinoma, Endometrioid / pathology. Carcinoma, Endometrioid / therapy. Case-Control Studies. Chemotherapy, Adjuvant. Female. Humans. Neoplasm Staging. Radiotherapy, Adjuvant. Retrospective Studies


27. Brustmann H: Poly(ADP-ribose) polymerase (PARP) and DNA-fragmentation factor (DFF45): expression and correlation in normal, hyperplastic and neoplastic endometrial tissues. Pathol Res Pract; 2007;203(2):65-72
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  • This study evaluated the immunohistochemical expression of poly(ADP-ribose) polymerase (PARP) and DNA fragmentation factor 45 (DFF45) in normal endometria (NE, n=13), non-atypical (NAH, n=22) and atypical hyperplasia (AH, n=14), endometrioid carcinoma (EC, n=34), serous carcinoma (SC, n=10), and clear cell carcinoma (CCC, n=2).
  • PARP immunoreactivity increased significantly from NE via NAH to AH (P=0.0004), and decreased from AH to endometrial carcinomas (P=0.0054).
  • No significant differences were calculated between AH and endometrial carcinomas (P=0.7495).
  • Immunoexpression of PARP and DFF45 is apparently altered in endometrial carcinomas as compared with non-neoplastic endometrial tissues, indicating impaired mechanisms of apoptosis in the former.
  • [MeSH-major] Adenocarcinoma / metabolism. Apoptosis. Apoptosis Regulatory Proteins / metabolism. Endometrial Hyperplasia / metabolism. Endometrial Neoplasms / metabolism. Endometrium / metabolism. Poly(ADP-ribose) Polymerases / metabolism
  • [MeSH-minor] Adenocarcinoma, Clear Cell / metabolism. Adenocarcinoma, Clear Cell / pathology. Carcinoma, Endometrioid / metabolism. Carcinoma, Endometrioid / pathology. Cell Nucleus / metabolism. Cell Nucleus / pathology. Cystadenocarcinoma, Serous / metabolism. Cystadenocarcinoma, Serous / pathology. Cytoplasm / metabolism. Cytoplasm / pathology. DNA Fragmentation. Female. Fluorescent Antibody Technique, Direct. Humans. Immunoenzyme Techniques

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  • (PMID = 17258405.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / caspase-activated DNase inhibitor; EC 2.4.2.30 / Poly(ADP-ribose) Polymerases
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28. Byrne JA, Maleki S, Hardy JR, Gloss BS, Murali R, Scurry JP, Fanayan S, Emmanuel C, Hacker NF, Sutherland RL, Defazio A, O'Brien PM: MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome. BMC Cancer; 2010;10:497
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  • [Title] MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome.
  • BACKGROUND: The four-transmembrane MAL2 protein is frequently overexpressed in breast carcinoma, and MAL2 overexpression is associated with gain of the corresponding locus at chromosome 8q24.12.
  • Independent expression microarray studies predict MAL2 overexpression in ovarian carcinoma, but these had remained unconfirmed.
  • MAL2 binds tumor protein D52 (TPD52), which is frequently overexpressed in ovarian carcinoma, but the clinical significance of MAL2 and TPD52 overexpression was unknown.
  • METHODS: Immunohistochemical analyses of MAL2 and TPD52 expression were performed using tissue microarray sections including benign, borderline and malignant epithelial ovarian tumours.
  • RESULTS: MAL2 and TPD52 were significantly overexpressed in high-grade serous carcinomas compared with serous borderline tumours.
  • MAL2 expression was highest in serous carcinomas relative to other histological subtypes, whereas TPD52 expression was highest in clear cell carcinomas.
  • MAL2 expression was not related to patient survival, however high-level TPD52 staining was significantly associated with improved overall survival in patients with stage III serous ovarian carcinoma (log-rank test, p < 0.001; n = 124) and was an independent predictor of survival in the overall carcinoma cohort (hazard ratio (HR), 0.498; 95% confidence interval (CI), 0.34-0.728; p < 0.001; n = 221), and in serous carcinomas (HR, 0.440; 95% CI, 0.294-0.658; p < 0.001; n = 182).
  • CONCLUSIONS: MAL2 is frequently overexpressed in ovarian carcinoma, and TPD52 overexpression is a favourable independent prognostic marker of potential value in the management of ovarian carcinoma patients.
  • [MeSH-major] Adenocarcinoma, Clear Cell / metabolism. Adenocarcinoma, Mucinous / metabolism. Cystadenocarcinoma, Serous / metabolism. Endometrial Neoplasms / metabolism. Neoplasm Proteins / metabolism. Ovarian Neoplasms / metabolism. Proteolipids / metabolism. Vesicular Transport Proteins / metabolism

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  • (PMID = 20846453.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MAL2 protein, human; 0 / Myelin and Lymphocyte-Associated Proteolipid Proteins; 0 / Neoplasm Proteins; 0 / Proteolipids; 0 / TPD52 protein, human; 0 / Vesicular Transport Proteins
  • [Other-IDs] NLM/ PMC2949808
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29. Dionigi G, Uccella S, Gandolfo M, Lai A, Bertocchi V, Rovera F, Tanda ML: Solitary intrathyroidal metastasis of renal clear cell carcinoma in a toxic substernal multinodular goiter. Thyroid Res; 2008;1(1):6
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  • [Title] Solitary intrathyroidal metastasis of renal clear cell carcinoma in a toxic substernal multinodular goiter.
  • She had a history of renal clear cell carcinoma of the left kidney, which had been resected 2 years previously.
  • A histological examination revealed a solitary metastasis of a clear cell renal cancer in a diffuse multinodular goiter.
  • The diagnosis can be suspected if the patient has a thyroid tumor and a past history of extrathyroid cancer.

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  • (PMID = 19014412.001).
  • [ISSN] 1756-6614
  • [Journal-full-title] Thyroid research
  • [ISO-abbreviation] Thyroid Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2596782
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30. Verhoest G, Manunta A, Bensalah K, Vincendeau S, Rioux-Leclercq N, Guillé F, Patard JJ: Laparoscopic partial nephrectomy with clamping of the renal parenchyma: initial experience. Eur Urol; 2007 Nov;52(5):1340-6
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  • Final pathologic examination revealed clear cell carcinoma in three cases and angiomyolipoma and oncocytoma in one case each.
  • [MeSH-major] Carcinoma, Renal Cell / surgery. Hemostasis, Endoscopic / methods. Kidney Neoplasms / surgery. Laparoscopy / methods. Nephrectomy / methods. Reperfusion Injury / prevention & control

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  • [CommentIn] Eur Urol. 2007 Nov;52(5):1303-5 [17566640.001]
  • (PMID = 17498865.001).
  • [ISSN] 0302-2838
  • [Journal-full-title] European urology
  • [ISO-abbreviation] Eur. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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31. Lin YG, Deavers M, Sasan F, Zager JS, Ramondetta LM: Clinical challenges presented by three simultaneous solid tumors. Gynecol Oncol; 2006 Dec;103(3):1159-63
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  • The simultaneous presentation of cervical carcinoma, renal cell carcinoma, and appendiceal carcinoma has not been previously described.
  • During her workup, she was diagnosed with mucinous appendiceal carcinoma and clear cell carcinoma of the kidney.
  • One year following surgery, she remains without evidence of disease and with continually improving nutritional status.
  • [MeSH-major] Neoplasms, Multiple Primary / diagnosis
  • [MeSH-minor] Adenocarcinoma, Clear Cell / diagnosis. Adenocarcinoma, Clear Cell / pathology. Adenocarcinoma, Clear Cell / therapy. Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / therapy. Appendiceal Neoplasms / diagnosis. Appendiceal Neoplasms / pathology. Appendiceal Neoplasms / therapy. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / therapy. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Kidney Neoplasms / diagnosis. Kidney Neoplasms / pathology. Kidney Neoplasms / therapy. Middle Aged. Neoplasm Staging. Uterine Cervical Neoplasms / diagnosis. Uterine Cervical Neoplasms / pathology. Uterine Cervical Neoplasms / therapy

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  • (PMID = 17055558.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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32. Kim DJ, Lee MH, Park TI, Bae HI: Expression and mutational analysis of c-kit in ovarian surface epithelial tumors. J Korean Med Sci; 2006 Feb;21(1):81-5
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  • The cases consisted of 33 cases, which included 13 serous cystadenocarcinomas, 1 borderline serous tumor, 8 mucinous cystadenocarcinomas, 6 borderline mucinous tumors and 5 clear cell carcinomas.

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33. Suhail M: Na, K-ATPase: Ubiquitous Multifunctional Transmembrane Protein and its Relevance to Various Pathophysiological Conditions. J Clin Med Res; 2010 Feb;2(1):1-17
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  • The Na(+), K(+)-ATPase (NKA) is an ubiquitous enzyme consisting of α, β and γ subunits, and is responsible for the creation and maintenance of the Na(+) and K(+) gradients across the cell membrane by transporting 3 Na(+) out and 2 K(+) into the cell.
  • Identification of naturally occurring regulators of  NKA could initiate the discovery of new hormone-like control systems involved in the etiology of selected disease processes, hence the importance of understanding the relation of the sodium pump and its ligands to disease.
  • NKA is also involved in hypertension, salt balance, cardiovascular and renal disorders, sperm capacitation, cell volume regulation, apoptosis, rheumatoid arthritis, sepsis, neurological disorders, lung edema clearance and preeclampsia.
  • NKA enzyme activity and subunit levels are reduced in carcinoma, NKA-β levels were highly reduced in an invasive form of human renal clear cell carcinoma, androgen-dependent prostate cancer, in early stages of urothelial cancer, as well as in poorly differentiated, highly motile carcinoma cell lines obtained from various tissues suggesting a functional link between reduced NKA-β expression and cancer progression.
  • It could be a target for the development of anticancer drugs as it serves as a signal transducer, it is a player in cell adhesion and its aberrant expression and activity are implicated in the development and progression of different cancers.

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  • (PMID = 22457695.001).
  • [ISSN] 1918-3003
  • [Journal-full-title] Journal of clinical medicine research
  • [ISO-abbreviation] J Clin Med Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC3299169
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34. Garzon JC, Lai FM, Mok TS, Manlulu AV, Ng CS, Lee TW, Yim AP: Clear cell carcinoma of the lung revisited. J Thorac Cardiovasc Surg; 2005 Oct;130(4):1198-9
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  • [Title] Clear cell carcinoma of the lung revisited.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Lung Neoplasms / pathology

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  • (PMID = 16214540.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Troisi R, Hatch EE, Titus-Ernstoff L, Hyer M, Palmer JR, Robboy SJ, Strohsnitter WC, Kaufman R, Herbst AL, Hoover RN: Cancer risk in women prenatally exposed to diethylstilbestrol. Int J Cancer; 2007 Jul 15;121(2):356-60
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  • Prenatal diethylstilbestrol (DES) exposure is associated with excess risks of clear cell adenocarcinoma (CCA), and breast cancer in older women.

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17390375.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogens, Non-Steroidal; 731DCA35BT / Diethylstilbestrol
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36. Michal M, Hes O, Nemcova J, Sima R, Kuroda N, Bulimbasic S, Franco M, Sakaida N, Danis D, Kazakov DV, Ohe C, Hora M: Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity. Virchows Arch; 2009 Jan;454(1):89-99
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  • [Title] Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity.
  • The tumors were composed of admixture of an epithelial clear cell component and prominent leiomyomatous stroma.
  • All tubular/glandular structures were lined by a fine capillary network.
  • RAT is a distinct morphologic entity, being different morphologically, immunohistochemically, and genetically from all renal tumors including conventional clear cell carcinoma and mixed epithelial and stromal tumor of kidney.

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  • [CommentIn] Virchows Arch. 2009 Apr;454(4):479-80 [19205727.001]
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  • (PMID = 19020896.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers; 0 / CAM 5.2 antigen; 0 / Keratin-20; 0 / Keratin-7; 0 / Mucin-1; 0 / Vimentin; 68238-35-7 / Keratins; EC 2.3.2.27 / Von Hippel-Lindau Tumor Suppressor Protein; EC 6.3.2.- / VHL protein, human
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37. Nakanuma Y, Sato Y, Harada K, Sasaki M, Xu J, Ikeda H: Pathological classification of intrahepatic cholangiocarcinoma based on a new concept. World J Hepatol; 2010 Dec 27;2(12):419-27
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  • To date, ICC was largely classified into adenocarcinoma and rare variants.
  • That is, ICC is classifiable into the conventional (bile duct) type, the bile ductular type, the intraductal neoplasm type and rare variants.
  • The conventional type is further divided into the small duct type (peripheral type) and large bile duct type (perihilar type).
  • The former is a tubular or micropapillary adenocarcinoma while the latter involves the intrahepatic large bile duct.
  • Bile ductular type resembles proliferated bile ductules and shows a replacing growth of the hepatic parenchyma.
  • Hepatic progenitor cell or stem cell phenotypes such as neural cell adhesion molecule expression are frequently expressed in the bile ductular type.
  • Intraductal type includes papillary and tubular neoplasms of the bile duct (IPNBs and ITNBs) and a superficial spreading type.
  • IPNB and ITNB show a spectrum from a preneoplastic borderline lesion to carcinoma and may have pancreatic counterparts.
  • At invasive sites, IPNB is associated with the conventional bile duct ICC and mucinous carcinoma.
  • Rare variants of ICC include squamous/adenosquamous cell carcinoma, mucinous/signet ring cell carcinoma, clear cell type, undifferentiated type, neuroendocrine carcinoma and so on.

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  • (PMID = 21191517.001).
  • [ISSN] 1948-5182
  • [Journal-full-title] World journal of hepatology
  • [ISO-abbreviation] World J Hepatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC3010511
  • [Keywords] NOTNLM ; Adenocarcinoma / Bile duct / Bile ductule / Intraductal neoplasm / Intrahepatic cholangiocarcinoma
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38. Lax SF: Molecular genetic changes in epithelial, stromal and mixed neoplasms of the endometrium. Pathology; 2007 Feb;39(1):46-54
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  • Endometrial carcinoma, endometrial stromal tumours and mixed malignant mesodermal tumours (MMMT) develop along distinctive molecular genetic pathways.
  • Two distinctive types of endometrial carcinoma are distinguished, type I and type II, which develop along distinctive pathways and show different clinical behaviour and histological features.
  • Type I carcinomas show endometrioid histology, are oestrogen-related and develop from atypical endometrial hyperplasia.
  • The molecular tumorigenesis is comparable to colorectal carcinoma with a step-like progression and an accumulation of genetic alterations.
  • Alterations of PTEN, K-Ras mutations and microsatellite instability are frequent and early events in type I carcinoma, whereas p53 mutations occur during progression to grade 3 carcinoma.
  • Serous and clear cell carcinomas are considered type II carcinomas which are mostly unrelated to oestrogen. p53 mutations occur in almost all serous carcinomas and seem to occur early, leading to massive chromosomal instability and rapid tumour progression.
  • Gene expression profiling has supported this dualistic model of endometrial carcinoma.
  • There is evidence of molecular differences between serous and clear cell carcinomas as well as between endometrioid carcinomas with and without microsatellite instability.
  • Endometrial stromal sarcomas (ESS; type I endometrial sarcoma) are oestrogen-related and seem to develop from endometrial stromal nodules (ESN).
  • They are histologically and genetically distinct from undifferentiated endometrial sarcoma (UES) which seem to be mostly unrelated to oestrogen (type II endometrial sarcoma).
  • In MMMT, which is considered a metaplastic carcinoma, p53 alteration occurs early, before clonal expansion and acquisition of genetic diversity during progression.
  • [MeSH-major] Endometrial Neoplasms / genetics. Endometrial Stromal Tumors / genetics. Molecular Biology. Neoplasms, Glandular and Epithelial / genetics

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  • (PMID = 17365822.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 82
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39. Soda T, Nishimura K, Kobayashi Y, Kato T, Tokugawa S, Kishikawa H, Ihara H, Ichikawa Y: [A case of synchronous contralateral renal cell carcinoma and urothelial carcinoma]. Hinyokika Kiyo; 2009 Aug;55(8):491-4
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  • [Title] [A case of synchronous contralateral renal cell carcinoma and urothelial carcinoma].
  • Histological examination findings showed that the right renal tumor was a renal cell carcinoma, clear cell type, G1, INFalpha, pT2, ly0, v0, and that the splenic tumor was an arteriovenous fistula.
  • Next, transurethral resection of the bladder tumor was performed and a histological examination showed urothelial carcinoma.
  • Left total nephroureterectomy and cystectomy were performed, and the histological diagnosis was urothelial carcinoma, G3, pT3, ly1, v2.
  • It is rare for a renal cell carcinoma and contralateral renal pelvic cancer to occur simultaneously, as only 15 cases including the present have been reported in Japan.
  • [MeSH-major] Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Kidney Pelvis. Neoplasms, Multiple Primary / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 19764535.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 13
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40. Staats PN, Clement PB, Young RH: Primary endometrioid adenocarcinoma of the vagina: a clinicopathologic study of 18 cases. Am J Surg Pathol; 2007 Oct;31(10):1490-501
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  • [Title] Primary endometrioid adenocarcinoma of the vagina: a clinicopathologic study of 18 cases.
  • Vaginal adenocarcinoma is the second most common primary cancer of the vagina, yet there has been very little study of most subtypes other than clear cell carcinoma.
  • We reviewed 18 cases of primary vaginal endometrioid adenocarcinoma, in our experience the second most common subtype.
  • On microscopic examination, each of the tumors had a pure or predominant component of typical endometrioid adenocarcinoma.
  • Other subtypes of adenocarcinoma (such as serous when the tumor has a papillary pattern) and atypical forms of endometriosis, including polypoid endometriosis, are the most common other differential diagnostic considerations.
  • The prognosis seems to be good in low-stage patients, with 11 patients alive and well and 2 alive with recurrent disease.
  • [MeSH-major] Carcinoma, Endometrioid / pathology. Vaginal Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Combined Modality Therapy. Cystadenocarcinoma, Serous / diagnosis. Diagnosis, Differential. Endometriosis / complications. Endometriosis / pathology. Female. Humans. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Treatment Outcome

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  • (PMID = 17895749.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. Duda-Szymańska J, Kaczmarek J, Papierz W: Cystic nephroma in adults. A report of two cases and review of the literature. Pol J Pathol; 2005;56(2):93-6
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  • In both patients the results of ultrasound and clinical examinations were not characteristic enough to establish the precise preoperative diagnosis.
  • Due to the age of the patients and the location of the lesions, possibility of clear cell carcinoma with cystic changes was considered.
  • [MeSH-minor] Adenocarcinoma, Clear Cell / pathology. Carcinoma, Renal Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged. Ultrasonography

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  • (PMID = 16092672.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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42. Gasljevic G, Lamovec J: Primary clear cell adenocarcinoma of the rectum: a case report. Int J Colorectal Dis; 2010 Oct;25(10):1259-60
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  • [Title] Primary clear cell adenocarcinoma of the rectum: a case report.
  • [MeSH-major] Adenocarcinoma, Clear Cell / surgery. Rectal Neoplasms / surgery
  • [MeSH-minor] Aged. Combined Modality Therapy. Disease-Free Survival. Endoscopy, Gastrointestinal. Humans. Laparoscopy. Male

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  • (PMID = 20405292.001).
  • [ISSN] 1432-1262
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Germany
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43. Hiromura T, Tanaka YO, Nishioka T, Satoh M, Tomita K: Clear cell adenocarcinoma of the uterine cervix arising from a background of cervical endometriosis. Br J Radiol; 2009 Jan;82(973):e20-2
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  • [Title] Clear cell adenocarcinoma of the uterine cervix arising from a background of cervical endometriosis.
  • The radiological findings of cervical clear cell adenocarcinoma (CCA) have not been described previously.
  • [MeSH-major] Adenocarcinoma, Clear Cell / etiology. Endometriosis / complications. Uterine Cervical Neoplasms / etiology


44. Orezzoli JP, Russell AH, Oliva E, Del Carmen MG, Eichhorn J, Fuller AF: Prognostic implication of endometriosis in clear cell carcinoma of the ovary. Gynecol Oncol; 2008 Sep;110(3):336-44
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  • [Title] Prognostic implication of endometriosis in clear cell carcinoma of the ovary.
  • OBJECTIVE: The aim of this study is to investigate whether the presence of endometriosis is a prognostic factor in patients diagnosed with clear cell carcinoma (CCC) of the ovary.
  • Advanced tumor stage at diagnosis (HR 13, 95% C.I.
  • Disease recurrence or death among optimally and completely cytoreduced patients was 31% and 59% for those with and without endometriosis respectively (P>0.05).
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Endometriosis / pathology. Ovarian Neoplasms / pathology

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  • (PMID = 18639330.001).
  • [ISSN] 1095-6859
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organoplatinum Compounds
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45. Gütgemann I, Lehman NL, Jackson PK, Longacre TA: Emi1 protein accumulation implicates misregulation of the anaphase promoting complex/cyclosome pathway in ovarian clear cell carcinoma. Mod Pathol; 2008 Apr;21(4):445-54
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  • [Title] Emi1 protein accumulation implicates misregulation of the anaphase promoting complex/cyclosome pathway in ovarian clear cell carcinoma.
  • Clear cell carcinoma is a clinically and pathologically distinct entity among surface epithelial ovarian neoplasms, recognized for its resistance to standard platinum-based chemotherapy at advanced stage disease and poor prognosis.
  • Despite advances in our understanding of the biology of other surface epithelial ovarian neoplasms, very little is known about the molecular genetic mechanisms that are involved in clear cell tumorigenesis.
  • Early mitotic inhibitor-1 (Emi1) protein is a key cell cycle regulator, that promotes S-phase and mitotic entry by inhibiting the anaphase promoting complex.
  • In cell culture systems, overexpression of Emi1 leads to tetraploidy and genomic instability, especially in the absence of normal p53 function.
  • We investigated Emi1 protein expression in ovarian neoplasms using a tissue microarray constructed from 339 primary ovarian surface epithelial (serous, endometrioid, clear cell, and mucinous) and peritoneal (serous) neoplasms, stromal and mesenchymal tumors, germ cell tumors, and normal ovarian tissue.
  • Significant overexpression of Emi1 protein was present in 82% (27/33) clear cell carcinoma, including one borderline tumor in a diffuse, granular cytoplasmic and perinuclear staining pattern, independent of patient age, presence of ovarian and/or pelvic endometriosis, and FIGO stage.
  • In contrast, only 10% (17/177) primary ovarian and primary peritoneal serous carcinomas, 0% (0/10) mucinous carcinomas, and 19% (6/32) endometrioid carcinomas exhibited significant Emi1 protein overexpression.
  • Accumulation of Emi1 protein was not linked to Ki-67 labeling index, but was directly correlated with cyclin E and inversely correlated with ER in clear cell carcinoma (P<0.001).
  • Emi1 protein expression was present in mixed endometrioid/clear cell tumors but absent in tumors with mixed serous/clear cell histology.
  • These findings represent a potentially important insight into the molecular pathway underlying ovarian carcinogenesis and provide a possible cell cycle model for the development and progression of ovarian clear cell carcinoma.
  • [MeSH-major] Adenocarcinoma, Clear Cell / metabolism. Cell Cycle Proteins / biosynthesis. F-Box Proteins / biosynthesis. Ovarian Neoplasms / metabolism. Signal Transduction / physiology. Ubiquitin-Protein Ligase Complexes / metabolism

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  • (PMID = 18204430.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / Cyclin E; 0 / F-Box Proteins; 0 / FBXO5 protein, human; 0 / Ki-67 Antigen; 0 / Receptors, Estrogen; EC 6.3.2.19 / Anaphase-Promoting Complex-Cyclosome; EC 6.3.2.19 / Ubiquitin-Protein Ligase Complexes
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46. Bats AS, Metzger U, Le Frere-Belda MA, Brisa M, Lecuru F: Malignant transformation of Gartner cyst. Int J Gynecol Cancer; 2009 Dec;19(9):1655-7
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  • [Title] Malignant transformation of Gartner cyst.
  • Malignant transformation of Gartner cysts is exceedingly rare.
  • Histologic examination showed a clear cell carcinoma.
  • [MeSH-major] Cell Transformation, Neoplastic. Cysts / pathology. Vaginal Diseases / pathology. Wolffian Ducts / pathology
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Aged. Disease Progression. Female. Humans. Urogenital Neoplasms / diagnosis. Urogenital Neoplasms / pathology

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  • (PMID = 19955954.001).
  • [ISSN] 1525-1438
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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47. Liu M, Wang JY, Zhang YG, Zhu SC, Lu ZH, Wan B: [Detection of urological and male genital tumors diagnosed in Beijing Hospital 1995 - 2004]. Zhonghua Yi Xue Za Zhi; 2007 Sep 11;87(34):2423-5
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  • The commonest malignancies included transitional cell carcinoma of bladder (n = 387), carcinoma of prostate (n = 271), and clear cell carcinoma of kidney (n = 250).
  • The ratio of metastatic carcinoma in prostate and kidney decreased with each passing year.
  • Before 1999 75.48% of the patients with prostate carcinoma visited the hospital because of low urinary tract symptom (LUTS), and only 12.48% because of abnormalities discovered during physical examination, However, after 2000 the percentage of the prostate carcinoma patients who visited the hospital because of LUST deceased to 54.44%, and those because of abnormalities discovered during physical examination increased to 40.99% (P < 0.01).
  • CONCLUSION: The improvement of diagnostic methods has changed the condition of tumor diagnosis in recent years.
  • [MeSH-major] Hospitalization / statistics & numerical data. Urogenital Neoplasms / diagnosis. Urogenital Neoplasms / epidemiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. China / epidemiology. Cross-Sectional Studies. Female. Humans. Kidney Neoplasms / diagnosis. Kidney Neoplasms / epidemiology. Male. Middle Aged. Prostatic Neoplasms / diagnosis. Prostatic Neoplasms / epidemiology. Retrospective Studies. Urinary Bladder Neoplasms / diagnosis. Urinary Bladder Neoplasms / epidemiology

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  • (PMID = 18036323.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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48. Ejaz AA, Geiger XJ, Wasiluk A: Focal segmental glomerulosclerosis in kidney resected for renal cell carcinoma. Int Urol Nephrol; 2005;37(2):345-9
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  • [Title] Focal segmental glomerulosclerosis in kidney resected for renal cell carcinoma.
  • A diagnosis of renal dysfunction is usually made on the basis of clinical, biochemical, radiologic, and renal tissue analysis.
  • Accurate diagnosis often requires a renal biopsy, but that procedure is contraindicated in certain clinical circumstances, particularly in patients who have only one kidney.
  • We describe a patient who previously had undergone left nephrectomy for a renal clear cell carcinoma, in whom the diagnosis of focal segmental glomerulosclerosis was made on retrospective analysis of remnant renal tissue from the patient's nephrectomy specimen.
  • [MeSH-major] Carcinoma, Renal Cell / complications. Glomerulosclerosis, Focal Segmental / complications. Kidney Neoplasms / complications


49. Will TA, Agarwal N, Petruzzelli GJ: Oral cavity metastasis of renal cell carcinoma: a case report. J Med Case Rep; 2008;2:313
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  • [Title] Oral cavity metastasis of renal cell carcinoma: a case report.
  • INTRODUCTION: Despite being reported rarely, renal cell carcinoma is the third most frequent neoplasm to metastasize to the head and neck region preceded only by breast and lung cancer.
  • Little information exists regarding the presentation and work-up of metastatic renal cell carcinoma in the oral cavity.
  • Immunoperoxidase testing was necessary to make the diagnosis of metastatic renal cell carcinoma and rule out other clear cell carcinomas of salivary gland origin.
  • CONCLUSION: Metastatic renal cell carcinoma is part of the differential diagnosis for patients presenting with a new head or neck lesion in the setting of a history of kidney cancer.
  • The physician needs to be prepared for the increased risk of bleeding and understand the importance of immunohistochemical staining to differentiate between metastatic renal cell carcinoma and malignancies of salivary origin.

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  • (PMID = 18823541.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2566576
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50. Hynninen P, Vaskivuo L, Saarnio J, Haapasalo H, Kivelä J, Pastoreková S, Pastorek J, Waheed A, Sly WS, Puistola U, Parkkila S: Expression of transmembrane carbonic anhydrases IX and XII in ovarian tumours. Histopathology; 2006 Dec;49(6):594-602
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  • In malignant tumours, the staining was most prominent in hypoxic regions.
  • Expression of CA XII was detected in all tumour categories, although the mean staining intensity was weaker than for CA IX in all groups except for clear cell carcinomas.
  • The expression pattern of CA IX suggests that it could also serve as a useful histopathological marker protein for hypoxia in malignant ovarian tumours.
  • [MeSH-major] Antigens, Neoplasm / metabolism. Carbonic Anhydrases / metabolism. Cell Membrane / enzymology. Cystadenocarcinoma, Mucinous / enzymology. Cystadenocarcinoma, Serous / enzymology. Cystadenoma, Mucinous / enzymology. Ovarian Neoplasms / enzymology

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  • (PMID = 17163844.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK40163
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Isoenzymes; EC 4.2.1.1 / CA9 protein, human; EC 4.2.1.1 / Carbonic Anhydrases; EC 4.2.1.1 / carbonic anhydrase XII
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51. Dimova I, Raitcheva S, Dimitrov R, Doganov N, Toncheva D: Correlations between c-myc gene copy-number and clinicopathological parameters of ovarian tumours. Eur J Cancer; 2006 Mar;42(5):674-9
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  • We established c-myc amplification in more than 30% in endometrioid and mixed epithelial ovarian carcinomas. c-myc gains were found in a high proportion (42.9%) of clear cell carcinomas.
  • We found associations between c-myc copy-number changes and clinicopathological parameters of ovarian tumours such as degree of malignancy and histological type.
  • We suggested that c-myc amplifications are characteristics for endometrioid, and c-myc gains for clear cell ovarian cancers.

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  • (PMID = 16458500.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; EC 2.7.11.1 / AURKA protein, human; EC 2.7.11.1 / Aurora Kinase A; EC 2.7.11.1 / Aurora Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.7.49 / Telomerase
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52. Negahban S, Daneshbod Y, Khademi B, Rasekhi AR, Soleimanpour H: Sinonasal clear cell adenocarcinoma: a case report. Acta Cytol; 2009 Sep-Oct;53(5):597-600
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  • [Title] Sinonasal clear cell adenocarcinoma: a case report.
  • BACKGROUND: Nonsalivary adenocarcinomas are the most interesting tumors found in the sinonasal area.
  • The clear cell type of this tumor is even more rare.
  • We present cytologic findings of clear cell sinonasal adenocarcinoma and related pitfalls.
  • Fine needle aspiration performed through the upper buccogingival canine fossa showed clusters of epithelial cells with clear cytoplasm, round nuclei, inconspicuous nucleoli and slight pleomorphism.
  • The mass was reported to be a clear cell neoplasm, and excision of the whole mass was performed.
  • CONCLUSION: Cytologic findings of this rare tumor overlap with those of salivary gland-type tumors with clear cell change and should be added to the list of head and neck tumors with clear cell change.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Nasal Mucosa / pathology. Paranasal Sinus Neoplasms / pathology

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  • (PMID = 19798893.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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53. Zhao J, Yart A, Frigerio S, Perren A, Schraml P, Weisstanner C, Stallmach T, Krek W, Moch H: Sporadic human renal tumors display frequent allelic imbalances and novel mutations of the HRPT2 gene. Oncogene; 2007 May 17;26(23):3440-9
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  • To determine the relevance of HRPT2 for sporadic renal tumors, clear cell, papillary and chromophobe renal cell carcinomas as well as oncocytomas and Wilms tumors were analysed for HRPT2 gene alterations.
  • Loss of heterozygosity (LOH) of HRPT2 was found in seven of 56 (12.5%) clear cell, three of 14 (21%) papillary, six of 10 (60%) chromophobe renal cell carcinomas, three of eight (38%) oncocytomas and four of 10 (40%) Wilms tumors.
  • In addition, two novel HRPT2 point mutations, causing K34Q and R292K changes in parafibromin, were detected in one clear cell carcinoma and one Wilms tumor, respectively.
  • These tumors displayed LOH of the remaining wild-type allele, but interestingly no von Hippel-Lindau (VHL) mutation.
  • Functional analysis revealed that the K34Q mutant species of parafibromin is, unlike wild-type protein, defective in suppressing cyclin D1 expression in vivo.
  • Taken together, these results suggest that renal cancer-associated mutations in parafibromin occur in the absence of VHL mutation, which in turn may contribute to constitutively elevated cyclin D1 expression and abnormal cell proliferation.

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  • (PMID = 17130827.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CDC73 protein, human; 0 / Tumor Suppressor Proteins; K3Z4F929H6 / Lysine
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54. Takami M, Kita E, Kuwana Y, Ohta Y, Nakayama Y, Fukai H, Matsumoto H, Takimoto T, Ichikawa G, Yamamoto T: [A case of brain metastasis from advanced ovarian clear-cell carcinoma during maintenance chemotherapy with irinotecan+cisplatin]. Gan To Kagaku Ryoho; 2008 Jul;35(7):1243-5
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  • [Title] [A case of brain metastasis from advanced ovarian clear-cell carcinoma during maintenance chemotherapy with irinotecan+cisplatin].
  • Clear-cell carcinoma of the ovary is a highly malignant neoplasm.
  • Survival of patients in the advanced stage is poor, and the best treatment is not clear.
  • We report here a case of a 57-year-old woman who had Stage IIIb advanced clearcell carcinoma of the ovary.
  • Considering the poor prognosis of clear-cell carcinoma, this regimen is thought to be effective for advanced clear-cell carcinoma of the ovary.
  • [MeSH-major] Adenocarcinoma, Clear Cell / drug therapy. Adenocarcinoma, Clear Cell / pathology. Brain Neoplasms / drug therapy. Camptothecin / analogs & derivatives. Cisplatin / therapeutic use. Ovarian Neoplasms / drug therapy. Ovarian Neoplasms / pathology

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  • (PMID = 18633273.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 7673326042 / irinotecan; Q20Q21Q62J / Cisplatin; XT3Z54Z28A / Camptothecin
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55. Mustea A, Pirvulescu C, Könsgen D, Braicu EI, Yuan S, Sun P, Lichtenegger W, Sehouli J: Decreased IL-1 RA concentration in ascites is associated with a significant improvement in overall survival in ovarian cancer. Cytokine; 2008 Apr;42(1):77-84
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  • The distribution of histological type of ovarian cancer was as follows: serous-papillary 43 (81.1%), 4 (7.5%) mucinous, 3 (5.7%) endometroid and 3 (5.7%) clear cell carcinoma.

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  • (PMID = 18329282.001).
  • [ISSN] 1096-0023
  • [Journal-full-title] Cytokine
  • [ISO-abbreviation] Cytokine
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / IL1RN protein, human; 0 / Interleukin 1 Receptor Antagonist Protein; 0 / Interleukin-1alpha; 0 / Interleukin-1beta
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56. Castiblanco G A, Pires N Y, Wistuba O I, Riquelme S E, Andrade M L, Corvalán R A: [Pathogenic role of PTEN tumor suppressor gene in ovarian cancer associated to endometriosis]. Rev Med Chil; 2006 Mar;134(3):271-8
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  • [Transliterated title] Rol patogénico del gen supresor de tumores PTEN en cáncer ovárico asociado a endometriosis.
  • BACKGROUND: Endometrioid carcinoma and clear cell carcinoma of the ovary are associated to endometriosis.
  • Somatic mutations of PTEN (10q23.3) are present in endometrial endometrioid carcinoma.
  • AIM: To determine the cellular proliferation index using Ki 67, the immunohistochemical expression of PTEN and LOH in patients with ovarian endometriosis without atypia (EN), ovarian endometriosis with atypia (EA) and endometriosis with adjacent ovarian carcinoma (ET).
  • MATERIAL AND METHODS: Paraffin embedded samples of 37 endometrioid and clear cell carcinomas of the ovary (CC/CE), 15 solitary ovarian EN and 15 ovarian EA, were studied.
  • [MeSH-major] Adenocarcinoma, Clear Cell / genetics. Carcinoma, Endometrioid / genetics. Endometriosis / genetics. Ovarian Neoplasms / genetics. PTEN Phosphohydrolase / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Cell Transformation, Neoplastic / genetics. Cell Transformation, Neoplastic / pathology. Disease Progression. Female. Genetic Markers. Humans. Immunohistochemistry. Ki-67 Antigen / genetics. Ki-67 Antigen / metabolism. Loss of Heterozygosity / genetics. Middle Aged


57. Alvarez-Múgica M, Bulnes Vázquez V, Jalón Monzón A, Gil A, Rodríguez Robles L, Miranda Aranzubía O: Late recurrence from a renal cell carcinoma: solitary right maxilar mass 17 years after surgery. Arch Esp Urol; 2010 Mar;63(2):147-50
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  • [Title] Late recurrence from a renal cell carcinoma: solitary right maxilar mass 17 years after surgery.
  • OBJECTIVES: To report a new case of late renal cell carcinoma recurrence.
  • METHODS: Renal cell carcinoma represents approximately 3% of all adult malignancies.
  • The histological diagnosis of the referred mass was clear cell carcinoma.
  • Examination under general anaesthesia and biopsy was performed revealing metastasis of a renal cell carcinoma.
  • CONCLUSIONS: The natural history of renal cell carcinoma is highly variable, metastases may present decades after the removal of the primary disease, however, only 1% of patients with renal cell carcinoma have metastases confined only to the head and neck, and solitary cervical metastatic mass is rare.
  • Moreover, renal cell carcinoma should be considered in the differential diagnosis of any growing lesion in the head and neck.
  • [MeSH-major] Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / surgery. Kidney Neoplasms / surgery. Maxillary Neoplasms / diagnosis. Neoplasms, Second Primary / diagnosis

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  • (PMID = 20378937.001).
  • [ISSN] 1576-8260
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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58. Dahut WL, Lakhani NJ, Gulley JL, Arlen PM, Kohn EC, Kotz H, McNally D, Parr A, Nguyen D, Yang SX, Steinberg SM, Venitz J, Sparreboom A, Figg WD: Phase I clinical trial of oral 2-methoxyestradiol, an antiangiogenic and apoptotic agent, in patients with solid tumors. Cancer Biol Ther; 2006 Jan;5(1):22-7
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  • Tumor biopsies were taken before and after starting the drug to assess for microvessel density by CD 31 and cell proliferation by Ki67 immunohistochemistry.
  • A patient with clear cell carcinoma of the ovary had a partial response at 1600 mg bid dose level lasting over three years.
  • 2ME2 treatment had no effect on microvessel density (CD31 immunostaining) and cell proliferation (Ki-67 immunostaining).
  • [MeSH-minor] Administration, Oral. Adult. Apoptosis. Capillaries / drug effects. Cell Proliferation / drug effects. Female. Humans. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 16357512.001).
  • [ISSN] 1538-4047
  • [Journal-full-title] Cancer biology & therapy
  • [ISO-abbreviation] Cancer Biol. Ther.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase I; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antineoplastic Agents; 4TI98Z838E / Estradiol; 6I2QW73SR5 / 2-methoxyestradiol
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59. Fijuth J: Brachytherapy in paediatric malignancies - review of indications. J Contemp Brachytherapy; 2010 Jun;2(2):81-83
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  • Treatment strategies directed towards the reduction of late side effects have significantly increased interest in brachytherapy, in particular of soft tissue sarcoma and clear cell adenocarcinoma, as in these malignancies often only a limited target volume needs to be treated by a significant radiation dose.

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  • (PMID = 27829850.001).
  • [ISSN] 1689-832X
  • [Journal-full-title] Journal of contemporary brachytherapy
  • [ISO-abbreviation] J Contemp Brachytherapy
  • [Language] eng
  • [Publication-type] Review; Journal Article
  • [Publication-country] Poland
  • [Keywords] NOTNLM ; HDR / LDR / brachytherapy / paediatric malignancies
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60. Suzuki H, Katoh A, Udaka T, Shiomori T, Fujimura T, Fujimura K, Kitamura T: Hyalinizing clear cell carcinoma arising from the base of the tongue. Acta Otolaryngol; 2006 Jun;126(6):653-6
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  • [Title] Hyalinizing clear cell carcinoma arising from the base of the tongue.
  • Hyalinizing clear cell carcinoma is a low-grade indolent and rare salivary gland tumor originally described by Milchgrub et al. in 1994.
  • The tumor was histopathologically diagnosed as hyalinizing clear cell carcinoma of the minor salivary gland.
  • The patient is currently free from disease 21 months after surgery.
  • The pathology, clinical characteristics, and treatment of hyalinizing clear cell carcinoma are bibliographically reviewed.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Hyalin. Salivary Gland Neoplasms / diagnosis. Salivary Glands, Minor. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Laryngoscopy. Magnetic Resonance Imaging. Neck Dissection. Stromal Cells / pathology. Tomography, X-Ray Computed. Tongue / pathology. Tongue / surgery

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  • (PMID = 16720452.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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61. Garg K, Soslow RA: Lynch syndrome (hereditary non-polyposis colorectal cancer) and endometrial carcinoma. J Clin Pathol; 2009 Aug;62(8):679-84
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  • [Title] Lynch syndrome (hereditary non-polyposis colorectal cancer) and endometrial carcinoma.
  • However, there are currently no such screening recommendations for women with endometrial carcinoma.
  • Expansion of these criteria to include tumour morphology (presence of tumour infiltrating lymphocytes and tumour heterogeneity including dedifferentiated/undifferentiated ECs) and topography (lower uterine segment localisation) as well as presence of synchronous ovarian clear cell carcinomas may significantly enhance the detection of patients with EC at risk for HNPCC.
  • [MeSH-major] Colorectal Neoplasms, Hereditary Nonpolyposis / diagnosis. Endometrial Neoplasms / diagnosis


62. Elgaaen BV, Haug KB, Wang J, Olstad OK, Fortunati D, Onsrud M, Staff AC, Sauer T, Gautvik KM: POLD2 and KSP37 (FGFBP2) correlate strongly with histology, stage and outcome in ovarian carcinomas. PLoS One; 2010;5(11):e13837
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  • [Title] POLD2 and KSP37 (FGFBP2) correlate strongly with histology, stage and outcome in ovarian carcinomas.
  • Improved insight into the molecular characteristics of the different subgroups of EOC is urgently needed, and should eventually lead to earlier diagnosis as well as more individualized and effective treatments.
  • Previously, we reported a limited number of mRNAs strongly upregulated in human osteosarcomas and other malignancies, and six were selected to be tested for a possible association with three subgroups of ovarian carcinomas and clinical parameters.
  • METHODOLOGY/PRINCIPAL FINDINGS: The six selected mRNAs were quantified by RT-qPCR in biopsies from eleven poorly differentiated serous carcinomas (PDSC, stage III-IV), twelve moderately differentiated serous carcinomas (MDSC, stage III-IV) and eight clear cell carcinomas (CCC, stage I-IV) of the ovary.
  • The gene expression level was related to the histological and clinical parameters of human ovarian carcinoma samples.
  • Except for POLD2, the serous carcinomas showed a similar transcription profile, being clearly different from CCC.
  • Another mRNA, Killer-specific secretory protein of 37 kDa (KSP37) showed six- to eight-fold higher levels in CCC stage I compared with the more advanced staged carcinomas, and correlated positively with an improved clinical outcome.
  • CONCLUSIONS/SIGNIFICANCE: We have identified two biomarkers which are markedly upregulated in two subgroups of ovarian carcinomas and are also associated with stage and outcome.
  • [MeSH-minor] Aged. Cystadenocarcinoma, Serous / diagnosis. Cystadenocarcinoma, Serous / genetics. Female. Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Humans. Neoplasm Staging. Neoplasms, Glandular and Epithelial / diagnosis. Neoplasms, Glandular and Epithelial / genetics. Outcome Assessment (Health Care). Ovarian Cysts / diagnosis. Ovarian Cysts / genetics. Prognosis. Reverse Transcriptase Polymerase Chain Reaction

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  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Blood Proteins; 0 / KSP37 protein, human; 0 / RNA, Messenger; EC 2.7.7.- / DNA Polymerase III; Ovarian epithelial cancer
  • [Other-IDs] NLM/ PMC2973954
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63. Lauffart B, Vaughan MM, Eddy R, Chervinsky D, DiCioccio RA, Black JD, Still IH: Aberrations of TACC1 and TACC3 are associated with ovarian cancer. BMC Womens Health; 2005 May 26;5:8
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  • The distribution pattern of expression of the two TACC proteins was different, with TACC3 loss being more common in serous papillary carcinoma compared with clear cell carcinomas, while TACC1 staining was less frequent in endometroid than in serous papillary tumor cores.

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  • (PMID = 15918899.001).
  • [ISSN] 1472-6874
  • [Journal-full-title] BMC women's health
  • [ISO-abbreviation] BMC Womens Health
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016056
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1175095
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64. Mallik AA, Katchy KC: Clear cell adenocarcinoma of the rectum. Med Princ Pract; 2005 Jan-Feb;14(1):58-60
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  • [Title] Clear cell adenocarcinoma of the rectum.
  • OBJECTIVE: To document the first case of clear cell adenocarcinoma of the rectum (a rare entity) in Kuwait.
  • Histopathological examination showed the tumor to be composed of lobules of mostly clear polygonal cells with round vesicular nuclei.
  • Glandular formation was occasional.
  • CONCLUSION: This report illustrates a case of intestinal clear cell adenocarcinoma with lymph node metastasis that suggested a poor prognosis.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Rectal Neoplasms / pathology

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  • (PMID = 15608484.001).
  • [ISSN] 1011-7571
  • [Journal-full-title] Medical principles and practice : international journal of the Kuwait University, Health Science Centre
  • [ISO-abbreviation] Med Princ Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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65. Yi Y, Mikhaylova O, Mamedova A, Bastola P, Biesiada J, Alshaikh E, Levin L, Sheridan RM, Meller J, Czyzyk-Krzeska MF: von Hippel-Lindau-dependent patterns of RNA polymerase II hydroxylation in human renal clear cell carcinomas. Clin Cancer Res; 2010 Nov 1;16(21):5142-52
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  • [Title] von Hippel-Lindau-dependent patterns of RNA polymerase II hydroxylation in human renal clear cell carcinomas.
  • PURPOSE: We have previously shown that von Hippel-Lindau (VHL) regulates ubiquitylation and proline 1465 hydroxylation of the large subunit of RNA polymerase II, Rpb1, in human renal clear cell carcinoma (RCC) cell lines.
  • Mechanistic analysis was performed in orthotopic xenograft model using 786-O RCC cells with wild-type (WT) VHL and knockdown of PHD2, characterized by high levels of Rpb1(OH) and PHD1.
  • Knockdown of PHD2 in 786-O VHL(+) cells resulted in a more malignant phenotype in orthotopic xenografts and higher expression of specific cell cycle regulators (CDC25A, cyclin-dependent kinase 2, CCNA2) compared with VHL(-) RCC cells.

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  • [Copyright] ©2010 AACR.
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  • (PMID = 20978146.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / P30 ES006096; United States / NCI NIH HHS / CA / R01 CA122346; United States / NCI NIH HHS / CA / CA122346; United States / NIEHS NIH HHS / ES / P30-ES006096
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Nuclear Proteins; EC 1.13.11.- / Dioxygenases; EC 1.14.11.2 / EGLN1 protein, human; EC 1.14.11.2 / Procollagen-Proline Dioxygenase; EC 1.14.11.29 / EGLN2 protein, human; EC 1.14.11.29 / Hypoxia-Inducible Factor-Proline Dioxygenases; EC 2.7.7.- / RNA Polymerase II; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
  • [Other-IDs] NLM/ NIHMS224724; NLM/ PMC2970636
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66. Allory Y, Matsuoka Y, Bazille C, Christensen EI, Ronco P, Debiec H: The L1 cell adhesion molecule is induced in renal cancer cells and correlates with metastasis in clear cell carcinomas. Clin Cancer Res; 2005 Feb 1;11(3):1190-7
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  • [Title] The L1 cell adhesion molecule is induced in renal cancer cells and correlates with metastasis in clear cell carcinomas.
  • PURPOSE: The L1 cell adhesion molecule is overexpressed in many human carcinomas.
  • The objectives of the study were to provide a comprehensive description of L1 distribution in human kidney and to establish the prognostic relevance of L1 expression in renal cell carcinomas (RCC).
  • In renal tumors, L1 was mainly detected in those originating from cells that do not express L1 in the normal kidney [i.e., 33 of 72 clear cell RCC (ccRCC) and 25 of 88 papillary RCC (papRCC)].
  • In these carcinomas, L1 expression was strongly correlated with Ki-67 proliferation index (ccRCC, P = 0.0059; papRCC, P = 0.0039), but only in ccRCC, the presence of L1 was associated with the risk of metastasis (P = 0.0121).
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Neural Cell Adhesion Molecule L1 / genetics

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  • (PMID = 15709188.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Neural Cell Adhesion Molecule L1; 0 / RNA, Messenger; 136601-57-5 / Cyclin D1
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67. Hayashi T, Miyagawa Y, Tsujimura A, Nonomura N, Minami M, Okuyama A: A case of renal cell carcinoma with multiple lung metastases refractory to interferon-alpha showing complete remission by interleukin-2 monotherapy. Int J Urol; 2006 Jun;13(6):805-8
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  • [Title] A case of renal cell carcinoma with multiple lung metastases refractory to interferon-alpha showing complete remission by interleukin-2 monotherapy.
  • We report a case in which a regimen of interleukin-2 (IL-2) achieved pathologically complete remission against renal cell carcinoma with multiple lung metastases.
  • Right radical nephrectomy was performed and the histological diagnosis was clear cell carcinoma, G3 > G2, INFbeta, pT3a, pN0.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Carcinoma, Renal Cell / therapy. Interleukin-2 / administration & dosage. Kidney Neoplasms / therapy. Lung Neoplasms / therapy
  • [MeSH-minor] Adenocarcinoma, Clear Cell / pathology. Adenocarcinoma, Clear Cell / radiography. Adenocarcinoma, Clear Cell / therapy. Combined Modality Therapy / methods. Humans. Interferon-alpha / administration & dosage. Middle Aged. Neoplasm Metastasis. Nephrectomy / methods. Remission Induction / methods

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  • (PMID = 16834666.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Interferon-alpha; 0 / Interleukin-2
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68. Tedeschi CA, Rubin M, Krumholz BA: Six cases of women with diethylstilbestrol in utero demonstrating long-term manifestations and current evaluation guidelines. J Low Genit Tract Dis; 2005 Jan;9(1):11-8
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  • In the late 1960s, an association was made with an increased incidence of clear cell adenocarcinoma in young women exposed in utero to DES.
  • The Centers for Disease Control have conducted a large DES Education Project and have established guidelines for management.
  • [MeSH-minor] Adenocarcinoma, Clear Cell / chemically induced. Adult. Cervical Intraepithelial Neoplasia / chemically induced. Female. Humans. Middle Aged. Pregnancy. Pregnancy Complications / chemically induced. Pregnancy, Ectopic / chemically induced. Time Factors. Uterine Cervical Neoplasms / chemically induced. Vaginal Neoplasms / chemically induced

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  • (PMID = 15870516.001).
  • [ISSN] 1089-2591
  • [Journal-full-title] Journal of lower genital tract disease
  • [ISO-abbreviation] J Low Genit Tract Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 731DCA35BT / Diethylstilbestrol
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69. Signorelli M, Guerra L, Buda A, Picchio M, Mangili G, Dell'Anna T, Sironi S, Messa C: Role of the integrated FDG PET/CT in the surgical management of patients with high risk clinical early stage endometrial cancer: detection of pelvic nodal metastases. Gynecol Oncol; 2009 Nov;115(2):231-5
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  • BACKGROUND: High risk clinical stage I endometrial cancer (grade 2 and deep myometrial invasion, grade 3 and serous and clear-cell carcinoma) had 10-35% of nodal involvement.
  • Diagnostic performance of 18F-FDG PET/CT in nodal disease detection was reported in terms of accuracy value both in a patient-based and a lesion site-based analysis.
  • Patient-based sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 18F-FDG PET/CT for detection of nodal disease were 77.8%, 100.0%, 100.0%, 93.1% and 94.4%, respectively.

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  • (PMID = 19695685.001).
  • [ISSN] 1095-6859
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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70. Klingler DW, Hemstreet GP, Balaji KC: Feasibility of robotic radical nephrectomy--initial results of single-institution pilot study. Urology; 2005 Jun;65(6):1086-9
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  • The final pathologic examination revealed conventional clear cell carcinoma in 4 patients (1 with pT1a, 2 with pT1b, and 1 with T3a) and a benign cyst in 1 patient.

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  • (PMID = 15913733.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. Kashiwada T, Shimizu H, Arai Y, Horie Y, Mizoo A, Takizawa S: [A case of anaphylactic reaction after pleurodesis with OK-432]. Nihon Kokyuki Gakkai Zasshi; 2009 Oct;47(10):965-8
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  • A 60-year-old woman had received adjuvant chemotherapy after abdominal hysterectomy for clear cell carcinoma of the endometrium.
  • She underwent drainage of left-side malignant pleural effusion followed by chemical pleurodesis with OK-432 via a chest tube.

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  • (PMID = 19882924.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 39325-01-4 / Picibanil
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72. Sakura M, Masuda H, Saito K, Koga F, Kawakami S, Kihara K: Collecting duct carcinoma with acquired cystic disease of the kidney in a long-term hemodialysis patient. Int J Urol; 2008 Jan;15(1):93-5
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  • [Title] Collecting duct carcinoma with acquired cystic disease of the kidney in a long-term hemodialysis patient.
  • We report a very rare case of collecting or Bellini duct carcinoma (CDC) found in a 60-year-old male who had received hemodialysis therapy for 21 years.
  • Screening with ultrasonography revealed a solid tumor originating from the cyst wall in the right kidney with acquired cystic disease of the kidney.
  • The tumor detected preoperatively was composed of papillary renal cell tumor (RCC) and multiple clear cell carcinoma, pathologically.
  • The histological diagnosis was multiple clear cell carcinomas.
  • [MeSH-major] Carcinoma, Renal Cell / etiology. Kidney Diseases, Cystic / etiology. Kidney Neoplasms / etiology. Renal Dialysis / adverse effects


73. Wang ZM, Pan Y, Yao Q, Ying LX: [Hyalinizing clear cell carcinoma]. Zhonghua Bing Li Xue Za Zhi; 2005 Jun;34(6):379-80
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  • [Title] [Hyalinizing clear cell carcinoma].
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Palatal Neoplasms / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Keratins / metabolism. Male. Mucin-1 / metabolism. Palate, Hard / surgery

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  • (PMID = 16185516.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Mucin-1; 68238-35-7 / Keratins
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74. Wang J, Wieslander C, Hansen G, Cass I, Vasilev S, Holschneider CH: Thin endometrial echo complex on ultrasound does not reliably exclude type 2 endometrial cancers. Gynecol Oncol; 2006 Apr;101(1):120-5
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  • [Title] Thin endometrial echo complex on ultrasound does not reliably exclude type 2 endometrial cancers.
  • OBJECTIVE: The objective of this study was to determine the ultrasonographic characteristics of the uterus and endometrial echo-complex (EEC) of postmenopausal patients diagnosed with type 2 endometrial cancer, including uterine papillary serous carcinoma (UPSC), clear cell carcinoma (CCC), and other endometrial high-grade carcinomas (HGC).
  • METHODS: Postmenopausal patients with type 2 endometrial cancer who underwent preoperative pelvic ultrasound were identified.
  • CONCLUSION: A thin or indistinct endometrial stripe, especially when associated with other ultrasound abnormalities does not reliably exclude type 2 endometrial cancer.

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  • (PMID = 16307792.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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75. Schmidt D, Horn LC, Kommoss F: [Histopathology of squamous cell carcinoma and adenocarcinoma of the uterine cervix]. Pathologe; 2005 Jul;26(4):255-61
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  • [Title] [Histopathology of squamous cell carcinoma and adenocarcinoma of the uterine cervix].
  • The introduction of a screening programme for carcinoma of the cervix uteri has lead to a reduction in the number of invasive carcinomas and to a relative increase in the frequency of preinvasive cervical lesions.
  • The most frequent type of invasive cancer of the cervix is squamous cell carcinoma.
  • Adenocarcinomas are much more infrequent.
  • Special subtypes of squamous cell carcinomas are the papillary (squamotransitional) subtype, the verrrucous subtype and the lymphoepithelioma-like subtype.
  • Among the various forms of adenocarcinoma, the mucinous subtype is the most frequent, either as endocervical or interstinal subtype.
  • Much more rare are the serous and clear cell carcinomas.
  • Great concern in daily diagnosis causes the adenoma malignum (minimal deviation adenocarcinoma), since this type of adenocarcinoma demonstrates only minor cytological atypia and greatly resembles the different types of endocervical glandular hyperplasia.A report on a cervical carcinoma should always include the typing and grading of the tumor.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Squamous Cell / pathology. Uterine Cervical Neoplasms / pathology


76. Bagby CM, MacLennan GT: Clear cell adenocarcinoma of the bladder and urethra. J Urol; 2008 Dec;180(6):2656
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  • [Title] Clear cell adenocarcinoma of the bladder and urethra.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Urethral Neoplasms / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 18951583.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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77. Tajiri K, Shimizu Y, Mihara H, Kawanishi Y, Orihara T, Takahashi H, Ishizawa S, Kawai S, Sugiyama T: Cholangiocarcinoma at the cystic duct discovered by lymph node metastases with clear cell transformation. Intern Med; 2006;45(18):1045-8
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  • [Title] Cholangiocarcinoma at the cystic duct discovered by lymph node metastases with clear cell transformation.
  • We encountered a case with cholangiocarcinoma of the cystic duct, which was first manifested by multiple lymph node metastases with clear cell changes resembling clear cell adenocarcinoma (CCC).
  • Because the clear cell changes were not prominent at the primary site, clear cell transformation might have occurred preferentially at the metastatic lesion in this case.
  • Alternatively, tumor cells with clear cell transformation, found at the primary site, might have high metastatic potential.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Bile Duct Neoplasms / pathology. Cholangiocarcinoma / pathology. Cystic Duct

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  • [CommentIn] Intern Med. 2006;45(18):1025-6 [17043371.001]
  • (PMID = 17043375.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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78. Delahunt B, Bethwaite PB, McCredie MR, Nacey JN: The evolution of collagen expression in sarcomatoid renal cell carcinoma. Hum Pathol; 2007 Sep;38(9):1372-7
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  • [Title] The evolution of collagen expression in sarcomatoid renal cell carcinoma.
  • The development of a sarcomatoid morphotype is recognized as an extreme form of dedifferentiation in renal cell carcinoma and is associated with a poor prognosis.
  • Although sarcomatoid renal cell carcinoma shows pronounced spindle cell morphology, clear cell renal cell carcinoma may show early spindle cell change with cellular elongation, and the prognostic significance of this is debated.
  • To determine the relationship between sarcomatoid renal cell carcinoma and clear cell renal cell carcinoma showing early spindle cell change, we have investigated collagen expression using immunohistochemistry in these 2 tumor types.
  • Both sarcomatoid renal cell carcinoma and early spindle cell change tumors showed pericellular interstitial expression of collagen types I and III, whereas sarcomatoid renal cell carcinoma also showed cytoplasmic expression of these collagen types.
  • Expression of these collagen types in typical clear cell renal cell carcinoma was, in occasional cases, limited to faint and patchy staining in a pericellular interstitial distribution.
  • Tumor cells did not stain for collagen type IV in sarcomatoid renal cell carcinoma, early spindle cell change, or typical clear cell renal cell carcinoma.
  • In sarcomatoid renal cell carcinoma, there was diffuse pericellular expression of collagen type V and patchy pericellular expression of collagen type VI, whereas early spindle cell change tumors showed patchy pericellular staining with antibodies to collagen type V.
  • Collagen type VI expression in early spindle cell change was largely confined to the vascular adventitia and areas of scarring, although very occasional foci of faint interstitial staining were also seen.
  • In typical clear cell renal cell carcinoma, staining of collagen types V and VI was limited to the vascular adventitia and foci of desmoplasia, whereas no staining of tumor cell cytoplasm were seen.
  • This study has shown that collagen expression of sarcomatoid renal cell carcinoma differs from that of early spindle cell change and provides validating evidence that these 2 morphotypes should not be considered together for classification purposes.
  • [MeSH-major] Carcinoma, Renal Cell / pathology. Collagen / analysis. Kidney Neoplasms / pathology. Sarcoma / pathology
  • [MeSH-minor] Collagen Type I / analysis. Collagen Type III / analysis. Collagen Type IV / analysis. Collagen Type V / analysis. Collagen Type VI / analysis. Cytoplasm / chemistry. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry

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  • (PMID = 17521699.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Collagen Type I; 0 / Collagen Type III; 0 / Collagen Type IV; 0 / Collagen Type V; 0 / Collagen Type VI; 9007-34-5 / Collagen
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79. Reichelt O, Gajda M, Chyhrai A, Wunderlich H, Junker K, Schubert J: Ultrasound-guided biopsy of homogenous solid renal masses. Eur Urol; 2007 Nov;52(5):1421-6
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  • Morphologic characteristics seen on ultrasound were categorized in (non-)homogenous and (non-)cystic renal masses and were related to findings of pathological examination.
  • RESULTS: In the ultrasound study, only 16 (22.9%) of the 76 clear-cell carcinomas but all 9 (100%) oncocytoma appeared homogenous and noncystic on high-resolution intraoperative ultrasound.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Staging / methods. Nephrectomy / methods. Prospective Studies. Reproducibility of Results


80. Ciobanu D, Vulpoi C, Găluşcă B, Florea N, Giuşcă SE, Căruntu ID: The value of the immunohistochemical exam in the diagnosis of the secondary malignant tumors to the thyroid gland. Rom J Morphol Embryol; 2007;48(2):113-9
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  • [Title] The value of the immunohistochemical exam in the diagnosis of the secondary malignant tumors to the thyroid gland.
  • The final diagnosis was established as follows: metastases of squamocellular carcinoma with different degree of differentiation (seven cases), metastases of adenocarcinoma (four cases), metastases of renal cell carcinoma (two cases), metastases of Hodgkin (one case) and non-Hodgkin lymphoma (two cases).
  • In four cases, the primary tumors were identified after the diagnosis of their metastases in thyroid.
  • The immunohistochemical staining was useful in the diagnosis of squamocellular carcinoma metastases, poorly differentiated (CK19 positive), of renal cell carcinoma with clear cells (CK18, CK19 and CD10 positive) and in the establishing of the tumoral origin for adenocarcinomas (CK7 positive--respiratory tract, CK20 positive--digestive tract).
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Renal Cell / diagnosis. Carcinoma, Squamous Cell / diagnosis. Immunohistochemistry / methods. Lymphoma / diagnosis. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / secondary
  • [MeSH-minor] Digestive System Neoplasms / diagnosis. Digestive System Neoplasms / pathology. Female. Humans. Lung Neoplasms / diagnosis. Lung Neoplasms / pathology. Male. Middle Aged. Molecular Diagnostic Techniques. Reproducibility of Results

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  • (PMID = 17641797.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Romania
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81. Cao D, Guo S, Allan RW, Molberg KH, Peng Y: SALL4 is a novel sensitive and specific marker of ovarian primitive germ cell tumors and is particularly useful in distinguishing yolk sac tumor from clear cell carcinoma. Am J Surg Pathol; 2009 Jun;33(6):894-904
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  • [Title] SALL4 is a novel sensitive and specific marker of ovarian primitive germ cell tumors and is particularly useful in distinguishing yolk sac tumor from clear cell carcinoma.
  • Ovarian primitive germ cell tumors (GCTs) are uncommon tumors and sometimes pose diagnostic challenges.
  • Among them, yolk sac tumor (YST) poses the greatest diagnostic difficulty and can be mistaken for clear cell carcinoma (CCC).
  • Here by immunohistochemistry, we investigated a novel marker SALL4 in 98 GCTs (29 YSTs, 18 dysgerminomas, 6 gonadoblastomas, 6 embryonal carcinomas, 15 immature and 12 mature teratomas, 7 carcinoid tumors, 3 strumal carcinoids, and 2 struma ovarii) with particular interest of exploring SALL4 to distinguish YST from CCC.
  • We found that SALL4 is strongly positive in more than 90% tumor cells in all YSTs, dysgerminomas, gonadoblastomas, and embryonal carcinomas.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Endodermal Sinus Tumor / diagnosis. Ovarian Neoplasms / diagnosis. Transcription Factors / biosynthesis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Neoplasms, Germ Cell and Embryonal / diagnosis. Neoplasms, Germ Cell and Embryonal / metabolism. Sensitivity and Specificity


82. Lin CK, Su HY, Tsai WC, Sheu LF, Jin JS: Association of cortactin, fascin-1 and epidermal growth factor receptor (EGFR) expression in ovarian carcinomas: correlation with clinicopathological parameters. Dis Markers; 2008;25(1):17-26
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  • [Title] Association of cortactin, fascin-1 and epidermal growth factor receptor (EGFR) expression in ovarian carcinomas: correlation with clinicopathological parameters.
  • We tested the hypothesis that cortactin, fascin-1 and EGFR expression correlates with clinicopathological parameters of the four most common ovarian surface epithelial carcinomas--serous cystadenocarcinoma, mucinous cystadenocarcinoma, endometrioid adenocarcinoma, and clear cell carcinoma.
  • Immunohistochemical analysis of cortactin, fascin-1 and EGFR was performed using tissue microarrays of 172 specimens comprising 69 serous cystadenocarcinomas, 44 mucinous cystadenocarcinomas, 45 endometrioid adenocarcinomas and 14 clear cell carcinomas.
  • All ovarian carcinomas showed significant expression of cortactin, fascin-1 and EGFR in staining intensity, tumor percentages and immunostaining scores.
  • The immunostaining scores of EGFR did not correlate with TNM stages, tumor differentiation or prognosis in the four ovarian surface epithelial carcinomas.
  • [MeSH-major] Carcinoma / metabolism. Carrier Proteins / biosynthesis. Cortactin / biosynthesis. Gene Expression Regulation, Neoplastic. Microfilament Proteins / biosynthesis. Ovarian Neoplasms / metabolism. Receptor, Epidermal Growth Factor / biosynthesis


83. Hou TC, Wu CC, Yang CR, Wang J: Synchronous renal cell carcinoma and clear cell hepatocellular carcinoma mimicking metastatic disease. Pathol Res Pract; 2010 May 15;206(5):342-5
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  • [Title] Synchronous renal cell carcinoma and clear cell hepatocellular carcinoma mimicking metastatic disease.
  • Double carcinomas of hepatocellular and renal cell carcinoma (RCC) are extremely rare, and among the reported cases, none of the hepatocellular carcinomas show clear cell change.
  • We report a case of synchronous double primary clear cell tumor in the liver and the kidney of a 70-year-old male.
  • The renal mass was a renal cell carcinoma of mixed clear and granular cell types, and the hepatic mass was a hepatocellular carcinoma with extensive clear cell change that mimicked a metastatic renal cell carcinoma.
  • A simple battery of immunohistochemical stains composed of hepatocyte antigen, and CD10 was performed to make a definite diagnosis.
  • [MeSH-major] Carcinoma, Hepatocellular / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Liver Neoplasms / pathology. Neoplasm Metastasis / pathology. Neoplasms, Multiple Primary / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male


84. Bukowski RM: Systemic therapy for metastatic renal cell carcinoma in treatment naïve patients: a risk-based approach. Expert Opin Pharmacother; 2010 Oct;11(14):2351-62
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  • [Title] Systemic therapy for metastatic renal cell carcinoma in treatment naïve patients: a risk-based approach.
  • Over 13,000 patients are estimated to die from this disease annually.
  • Cloning of the VHL gene, recognition of the associated abnormalities in sporadic clear-cell carcinoma, and its role as a regulator of the hypoxic response, were important milestones in our understanding of renal-cell carcinoma (RCC) biology and the recognition of the vascular endothelial growth factor (VEGF) dependency of RCC.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Carcinoma, Renal Cell / drug therapy. Kidney Neoplasms / drug therapy

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  • (PMID = 20586712.001).
  • [ISSN] 1744-7666
  • [Journal-full-title] Expert opinion on pharmacotherapy
  • [ISO-abbreviation] Expert Opin Pharmacother
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antineoplastic Agents; 0 / Immunosuppressive Agents; 0 / Protein Kinase Inhibitors; 0 / Vascular Endothelial Growth Factor A
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85. Yamashita R, Yamaguchi R, Yuen K, Niwakawa M, Tobisu K: Urothelial carcinoma (clear cell variant) diagnosed with useful immunohistochemistry stain. Int J Urol; 2006 Nov;13(11):1448-50
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  • [Title] Urothelial carcinoma (clear cell variant) diagnosed with useful immunohistochemistry stain.
  • The case is reported of urothelial carcinoma (clear cell variant) that was diagnosed with useful immunohistochemistry stain.
  • A 70-year-old man, who had undergone left radical nephrectomy for renal cell carcinoma in August 2003 and partial lobectomy for pulmonary metastasis in May 2005, complained of hematuria in June 2005.
  • The pathological diagnosis was difficult due to diffuse clear cell appearance.
  • Immunohistochemistry stain showed urothelial carcinoma, not metastasis of the renal cell carcinoma.
  • Finally it was diagnosed as urothelial carcinoma clear cell variant.
  • Urothelial carcinoma has many variants that show a variety of appearances and characteristics.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Immunohistochemistry / methods. Urinary Bladder Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Keratin-7 / analysis. Male. Reproducibility of Results. Sensitivity and Specificity. Urothelium / chemistry. Urothelium / pathology

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  • (PMID = 17083402.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Keratin-7
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86. Coosemans A, Moerman P, Verbist G, Maes W, Neven P, Vergote I, Van Gool SW, Amant F: Wilms' tumor gene 1 (WT1) in endometrial carcinoma. Gynecol Oncol; 2008 Dec;111(3):502-8
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  • [Title] Wilms' tumor gene 1 (WT1) in endometrial carcinoma.
  • To expand the knowledge on the biological role of WT1 in other uterine cancers, we focused on its detection in endometrial carcinoma.
  • METHODS: In total, 36 paraffin-embedded tumors were available for WT1 immunohistochemical (IHC) analysis including endometrial endometrioid carcinoma (n=24), serous carcinoma (n=9) and clear cell carcinoma (n=3).
  • Of these tumors, 32 snap frozen tissue samples were available for RT-PCR (endometrioid carcinoma (23), serous carcinoma (7) and clear cell carcinoma (2)).
  • CONCLUSION: Although WT1 is expressed in a majority of endometrial carcinomas, a heterogeneous staining pattern is observed.
  • [MeSH-minor] Adenocarcinoma, Clear Cell / genetics. Adenocarcinoma, Clear Cell / metabolism. Adenocarcinoma, Clear Cell / pathology. Aged. Biopsy. Carcinoma, Endometrioid / genetics. Carcinoma, Endometrioid / metabolism. Carcinoma, Endometrioid / pathology. Cystadenocarcinoma, Serous / genetics. Cystadenocarcinoma, Serous / metabolism. Cystadenocarcinoma, Serous / pathology. Female. Humans. Immunohistochemistry. Neoplasm Staging. Reverse Transcriptase Polymerase Chain Reaction. WT1 Proteins / biosynthesis. WT1 Proteins / genetics

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  • (PMID = 18929401.001).
  • [ISSN] 1095-6859
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / WT1 Proteins
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87. Uharcek P: Prognostic factors in endometrial carcinoma. J Obstet Gynaecol Res; 2008 Oct;34(5):776-83
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  • [Title] Prognostic factors in endometrial carcinoma.
  • Endometrial carcinoma is the most common malignancy of the female genital tract in industrialized countries, and occurs predominantly after the menopause.
  • Although most endometrial carcinomas are detected at low stage, there is still a significant mortality from the disease.
  • In order to improve treatment and follow-up of endometrial carcinoma patients, the importance of various prognostic factors has been extensively studied.
  • Over the past few decades, several studies have demonstrated the prognostic importance of different parameters including lymph node status, histological type of carcinoma (serous carcinoma and clear cell carcinomas are poor prognostic types), histological grade, stage of disease, depth of myometrial invasion, lymphovascular space involvement and cervical involvement.
  • [MeSH-major] Carcinoma, Endometrioid / pathology. Endometrial Neoplasms / pathology


88. Fujiu K, Miyamoto H, Hashimoto S, Suzuki N, Takano Y, Teranishi Y, Sakuma H, Suzuki H: A case of diaphragmatic clear cell carcinoma in a patient with a medical history of ovarian endometriosis. Int J Clin Oncol; 2010 Oct;15(5):489-92
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  • [Title] A case of diaphragmatic clear cell carcinoma in a patient with a medical history of ovarian endometriosis.
  • We present a case of clear cell carcinoma located in the diaphragm in a patient with a medical history of ovarian endometriosis.
  • Histopathological examination revealed the presence of clear cells and hobnail cells.
  • The clear cells contained pale or eosinophilic cytoplasm and were arranged in a solid pattern.
  • The findings were compatible with those of ovarian clear cell carcinoma.

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  • (PMID = 20221659.001).
  • [ISSN] 1437-7772
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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89. Nagase S, Katabuchi H, Hiura M, Sakuragi N, Aoki Y, Kigawa J, Saito T, Hachisuga T, Ito K, Uno T, Katsumata N, Komiyama S, Susumu N, Emoto M, Kobayashi H, Metoki H, Konishi I, Ochiai K, Mikami M, Sugiyama T, Mukai M, Sagae S, Hoshiai H, Aoki D, Ohmichi M, Yoshikawa H, Iwasaka T, Udagawa Y, Yaegashi N, Japan Society of Gynecologic Oncology: Evidence-based guidelines for treatment of uterine body neoplasm in Japan: Japan Society of Gynecologic Oncology (JSGO) 2009 edition. Int J Clin Oncol; 2010 Dec;15(6):531-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Endometrial carcinoma is one of the most common gynecologic malignancies in Japan and its incidence has increased recently.
  • Although surgery is the cornerstone of the management of patients with endometrial cancer, there is significant variation in Japan with regard to the type of hysterectomy employed.
  • The 2009 edition included topics not addressed in the previous edition including the treatment of mesenchymal tumors, for example leiomyosarcoma, and sections covering the treatment of serous and clear-cell adenocarcinoma.
  • [MeSH-major] Adenocarcinoma, Clear Cell / therapy. Endometrial Neoplasms / therapy. Uterine Neoplasms / therapy

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  • (PMID = 21069552.001).
  • [ISSN] 1437-7772
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Practice Guideline; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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90. Kobayashi H, Kajiwara H, Kanayama S, Yamada Y, Furukawa N, Noguchi T, Haruta S, Yoshida S, Sakata M, Sado T, Oi H: Molecular pathogenesis of endometriosis-associated clear cell carcinoma of the ovary (review). Oncol Rep; 2009 Aug;22(2):233-40
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  • [Title] Molecular pathogenesis of endometriosis-associated clear cell carcinoma of the ovary (review).
  • Among EOC, clear cell carcinoma (CCC) and endometrioid adenocarcinoma (EAC) differ from the other histological types with respect to their clinical characteristics and carcinogenesis.
  • [MeSH-major] Adenocarcinoma, Clear Cell / etiology. Endometriosis / complications. Ovarian Neoplasms / etiology
  • [MeSH-minor] Cell Cycle Proteins / physiology. F-Box Proteins / physiology. Female. Genes, Tumor Suppressor. Hepatocyte Nuclear Factor 1-beta / physiology. Humans. Loss of Heterozygosity. Microsatellite Instability. Oxidative Stress. Protein Kinases / physiology. TOR Serine-Threonine Kinases


91. Hajj P, Ferlicot S, Massoud W, Awad A, Hammoudi Y, Charpentier B, Durrbach A, Droupy S, Benoît G: Prevalence of renal cell carcinoma in patients with autosomal dominant polycystic kidney disease and chronic renal failure. Urology; 2009 Sep;74(3):631-4
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  • [Title] Prevalence of renal cell carcinoma in patients with autosomal dominant polycystic kidney disease and chronic renal failure.
  • OBJECTIVES: To study the prevalence and the characteristics of renal cell carcinoma (RCC) in patients with autosomal dominant polycystic kidney disease (ADPKD) in our series.
  • Of 79 patients, 50 had end-stage renal disease (ESRD) and were on hemodialysis or had received a transplant for >1 year.
  • On histologic examination, 11 of 89 kidneys were diagnosed with carcinomas.
  • Regarding the histologic type, there were 7 of 12 (58.3%) clear cell carcinomas and the remaining 5 (41.7%) were tubulopapillary carcinomas.
  • [MeSH-major] Carcinoma, Renal Cell / complications. Carcinoma, Renal Cell / epidemiology. Kidney Failure, Chronic / complications. Kidney Neoplasms / complications. Kidney Neoplasms / epidemiology. Polycystic Kidney, Autosomal Dominant / complications


92. Yoshioka N, Suzuki N, Uekawa A, Kiguchi K, Ishizuka B: POU6F1 is the transcription factor that might be involved in cell proliferation of clear cell adenocarcinoma of the ovary. Hum Cell; 2009 Nov;22(4):94-100
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  • [Title] POU6F1 is the transcription factor that might be involved in cell proliferation of clear cell adenocarcinoma of the ovary.
  • Clear cell adenocarcinoma of the ovary often shows resistance to anticancer agents.
  • We investigated new molecules to use when developing molecular-targeting therapy for clear cell adenocarcinoma of the ovary.
  • RMG-I cells without invasive potential and RMG-V cells with invasive potential (derived from clear cell adenocarcinoma of the ovary) were subjected to complementary deoxyribonucleic acid microarray analysis.
  • Caveolin-1, a molecule involved in cellular motility and invasion, showed differing expression between the two cell lines.
  • The results showed suppression of RMG-V cell infiltration by siRNA, but proliferation of the cancer cells was also suppressed.
  • In other words, RMG-V cell infiltration may have been suppressed simply because cell proliferation was suppressed by RNA interference.
  • Clear cell adenocarcinoma of the ovary shows little response to standard therapy.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Cell Proliferation. Ovarian Neoplasms / pathology. POU Domain Factors / physiology. Transcription Factors / physiology
  • [MeSH-minor] Caveolin 1 / metabolism. Caveolin 1 / physiology. Cell Line, Tumor. Female. Humans. Neoplasm Invasiveness. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 19874398.001).
  • [ISSN] 1749-0774
  • [Journal-full-title] Human cell
  • [ISO-abbreviation] Hum. Cell
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Caveolin 1; 0 / POU Domain Factors; 0 / POU6F1 protein, human; 0 / Transcription Factors
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93. Shepherd ES, Lowe DA, Shepherd JH: Targeted selective trachelo-colpectomy for preservation of fertility in a young woman with vaginal clear cell carcinoma. J Obstet Gynaecol; 2010 May;30(4):420-1
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  • [Title] Targeted selective trachelo-colpectomy for preservation of fertility in a young woman with vaginal clear cell carcinoma.
  • [MeSH-major] Adenocarcinoma, Clear Cell / surgery. Fertility. Vaginal Neoplasms / surgery

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  • (PMID = 20455712.001).
  • [ISSN] 1364-6893
  • [Journal-full-title] Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
  • [ISO-abbreviation] J Obstet Gynaecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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94. Gimm T, Wiese M, Teschemacher B, Deggerich A, Schödel J, Knaup KX, Hackenbeck T, Hellerbrand C, Amann K, Wiesener MS, Höning S, Eckardt KU, Warnecke C: Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1. FASEB J; 2010 Nov;24(11):4443-58
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  • The potential link between hypoxia and an oncogenic signaling pathway might play a pivotal role in renal clear-cell carcinoma characterized by constitutive activation of hypoxia-inducible factors (HIFs), and hence prompted us to analyze HIG2 regulation and function in detail.
  • HIG2 was up-regulated by hypoxia and HIF inducers in all cell types and mouse organs investigated and abundantly expressed in renal clear-cell carcinomas.
  • HIG2 could be detected in atherosclerotic arteries and fatty liver disease, suggesting that this ubiquitously inducible HIF-1 target gene may play an important functional role in diseases associated with pathological lipid accumulation.
  • [MeSH-major] Carcinoma, Renal Cell / metabolism. Hypoxia-Inducible Factor 1, alpha Subunit / metabolism. Kidney Neoplasms / metabolism. Neoplasm Proteins / metabolism
  • [MeSH-minor] Animals. Anoxia / physiopathology. Cell Line. Cell Line, Tumor. Cell Proliferation. Cytokines / metabolism. Gene Expression Regulation. HeLa Cells. Humans. Lipid Metabolism. Mice. Mice, Inbred BALB C. Mice, Transgenic. Promoter Regions, Genetic / genetics. Protein Binding. Signal Transduction. Transcriptional Activation / genetics. Wnt1 Protein / metabolism

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  • (PMID = 20624928.001).
  • [ISSN] 1530-6860
  • [Journal-full-title] FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • [ISO-abbreviation] FASEB J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cytokines; 0 / HIF1A protein, human; 0 / HIG2 protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / Neoplasm Proteins; 0 / Wnt1 Protein
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95. Alshumrani G, O'Malley M, Ghai S, Metser U, Kachura J, Finelli A, Mattar K, Panzarella T: Small (&lt; or = 4 cm) cortical renal tumors: characterization with multidetector CT. Abdom Imaging; 2010 Aug;35(4):488-93
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  • Two radiologists reviewed CT studies blinded to pathology results and recorded the morphologic and enhancement features of the tumors.
  • RESULTS: The 47 tumors (median diameter, 2.5 cm; range, 0.6-4.0 cm) included: 26 (55%) clear cell renal cell carcinomas; 9 (19%) oncocytomas; 7 (15%) papillary renal cell carcinomas; 2 (4%) chromophobe renal cell carcinomas; 2 (4%) inflammatory pseudotumors; and 1 (2%) angiomyolipoma with minimal fat.
  • Amongst the three commonest tumors, heterogeneity was seen in 23/26 (88%) clear cell renal cell carcinomas, 6/9 (67%) oncocytomas, and 2/7 (29%) papillary renal cell cancer.
  • Median (minimum-maximum) absolute nephrographic phase enhancement (nephrographic minus unenhanced phase) was: clear cell renal cell carcinomas 65 HU (34-120), oncocytomas 80 HU (51-111), and papillary renal cell carcinomas 16 HU (7-32).
  • CONCLUSION: Absolute nephrographic phase enhancement of < or = 32 HU distinguished papillary renal cell carcinomas from clear cell renal cell carcinomas and oncocytomas.
  • [MeSH-minor] Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / radiography. Adult. Aged. Aged, 80 and over. Angiomyolipoma / pathology. Angiomyolipoma / radiography. Carcinoma, Renal Cell / pathology. Carcinoma, Renal Cell / radiography. Female. Granuloma, Plasma Cell / pathology. Granuloma, Plasma Cell / radiography. Humans. Kidney Diseases / pathology. Kidney Diseases / radiography. Male. Middle Aged

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  • (PMID = 19536589.001).
  • [ISSN] 1432-0509
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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96. Chan CC, Collins AB, Chew EY: Molecular pathology of eyes with von Hippel-Lindau (VHL) Disease: a review. Retina; 2007 Jan;27(1):1-7
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  • [Title] Molecular pathology of eyes with von Hippel-Lindau (VHL) Disease: a review.
  • BACKGROUND: von Hippel-Lindau Disease (VHL) is an autosomal dominant inherited systemic cancer syndrome.
  • This finding is in line with similar findings in VHL-associated CNS hemangioblastoma and renal clear cell carcinomas.
  • Increases of vascular endothelial growth factor (VEGF), hypoxia induced factor (HIF), and ubiquitin are found in ocular hemangioblastomas.Interestingly, tumorlet cells, which are composed of poorly differentiated small cells with prominent dark nuclei and little cytoplasm, as well as several stem cell markers, such as erythropoietin (Epo), Epo receptor (EpoR), and CD133, are present in ocular VHL lesions.
  • [MeSH-major] Hemangioblastoma / pathology. Optic Nerve Neoplasms / pathology. Retinal Neoplasms / pathology. von Hippel-Lindau Disease / pathology

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  • (PMID = 17218907.001).
  • [ISSN] 0275-004X
  • [Journal-full-title] Retina (Philadelphia, Pa.)
  • [ISO-abbreviation] Retina (Philadelphia, Pa.)
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 EY000222-22; United States / Intramural NIH HHS / / Z99 EY999999
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] EC 6.3.2.19 / VHL protein, human; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
  • [Number-of-references] 56
  • [Other-IDs] NLM/ NIHMS22186; NLM/ PMC1971131
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97. Kapur R, Sugar J, Edward DP: Conjunctival mucoepidermoid carcinoma: clear cell variant. Arch Ophthalmol; 2005 Sep;123(9):1265-8
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  • [Title] Conjunctival mucoepidermoid carcinoma: clear cell variant.
  • [MeSH-major] Carcinoma, Mucoepidermoid / pathology. Conjunctival Neoplasms / pathology

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  • (PMID = 16157811.001).
  • [ISSN] 0003-9950
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY 01792
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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98. Brown LA, Irving J, Parker R, Kim H, Press JZ, Longacre TA, Chia S, Magliocco A, Makretsov N, Gilks B, Pollack J, Huntsman D: Amplification of EMSY, a novel oncogene on 11q13, in high grade ovarian surface epithelial carcinomas. Gynecol Oncol; 2006 Feb;100(2):264-70
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  • [Title] Amplification of EMSY, a novel oncogene on 11q13, in high grade ovarian surface epithelial carcinomas.
  • EMSY maps to 11q13.5 and is amplified in 13% of breast and 17% of ovarian carcinomas.
  • To further characterize the role of EMSY within this amplicon, we evaluated both the amplification profiles and RNA expression levels of EMSY and two other genes from the 11q13 amplicon in an additional series of 22 ovarian carcinomas.
  • RESULTS: EMSY amplification was seen in 52/285 (18%) high grade papillary serous carcinomas, 4/27 (15%) high grade endometrioid carcinomas, 3/38 (8%) clear cell carcinomas, and 3/10 (30%) undifferentiated carcinomas. aCGH mapping of 11q13 in ovarian cancer showed that EMSY localized to the region with the highest frequency of copy number gain.


99. Shibata K, Kajiyama H, Mizokami Y, Ino K, Nomura S, Mizutani S, Terauchi M, Kikkawa F: Placental leucine aminopeptidase (P-LAP) and glucose transporter 4 (GLUT4) expression in benign, borderline, and malignant ovarian epithelia. Gynecol Oncol; 2005 Jul;98(1):11-8
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  • [Title] Placental leucine aminopeptidase (P-LAP) and glucose transporter 4 (GLUT4) expression in benign, borderline, and malignant ovarian epithelia.
  • OBJECTIVE: Increased glucose consumption is a characteristic of malignant cells.
  • Glucose is transported into the cell via facilitative glucose transporters, which are known to be members of a supergene family.
  • P-LAP is a cell surface aminopeptidase, and is a synonym for oxytocinase.
  • The authors evaluated P-LAP and GLUT4 expression in benign, borderline, and malignant ovarian epithelia.
  • METHODS: Histologic sections of formalin-fixed, paraffin-embedded specimens from 11 patients with benign serous or mucinous cystadenomas, 14 patients with serous or mucinous borderline tumors, and 80 patients with epithelial-ovarian adenocarcinomas (29 serous, 17 endometrioid, 14 mucinous, and 20 clear cell adenocarcinomas) were stained for P-LAP and GLUT4 using each polyclonal antibody.
  • P-LAP was expressed in 23 of 29 in serous, 15 of 17 endometrioid, 13 of 14 mucinous, and all clear-cell adenocarcinomas.
  • The tendency toward increased P-LAP expression with advancing grade was observed in serous adenocarcinomas.
  • GLUT4 was expressed in 13 of 29 serous, 13 of 17 endometrioid, 13 of 14 mucinous, and 18 of 20 clear-cell adenocarcinomas.
  • In invasive carcinomas, there was a direct correlation between P-LAP immunoreactivity and GLUT4 immunoreactivity (correlation coefficient [r] = 0.58; P < 0.01).
  • Further study to investigate the roles of P-LAP and GLUT4 in ovarian carcinoma is needed.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Growth Processes / physiology. Cell Line, Tumor. Epithelium / enzymology. Epithelium / metabolism. Female. Glucose Transporter Type 4. Humans. Middle Aged. Neoplasm Invasiveness. Ovarian Diseases / enzymology. Ovarian Diseases / metabolism. Ovarian Diseases / pathology. Transfection

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  • (PMID = 15907336.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glucose Transporter Type 4; 0 / Monosaccharide Transport Proteins; 0 / Muscle Proteins; 0 / SLC2A4 protein, human; EC 3.4.11.3 / Cystinyl Aminopeptidase; EC 3.4.11.3 / leucyl-cystinyl aminopeptidase
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100. Lindahl B, Persson J, Ranstam J, Willén R: Long-term survival in uterine clear cell carcinoma and uterine papillary serous carcinoma. Anticancer Res; 2010 Sep;30(9):3727-30
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  • [Title] Long-term survival in uterine clear cell carcinoma and uterine papillary serous carcinoma.
  • Uterine clear cell carcinoma (UCC) and uterine papillary serous carcinoma (UPSC) are rare entities that differ in clinical behavior from endometrial adenocarcinoma.
  • Compared with endometrioid adenocarcinoma, they more often metastasize early and more commonly in the upper abdomen including the omentum.
  • In stage Ia, 2/46 patients died of their disease and amongst all the stages, 30/109 patients died of their disease.
  • [MeSH-major] Adenocarcinoma, Clear Cell / mortality. Cystadenocarcinoma, Serous / mortality. Uterine Neoplasms / mortality

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  • (PMID = 20944161.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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