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1. Takagi M, Akiba T: [A case of surgically treated primary lung cancer with myasthenia gravis]. Nihon Kokyuki Gakkai Zasshi; 2007 Feb;45(2):198-201
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  • [Title] [A case of surgically treated primary lung cancer with myasthenia gravis].
  • A 62-year-old woman, who had received immunosuppressive treatment for myasthenia gravis, was admitted to our hospital for the treatment of a right pulmonary tumor.
  • In October 2003, a chest computed tomography showed a nodule-like lesion in the right lung.
  • A tumor biopsy showed histological features of bronchioloalveolar carcinoma.
  • It has been reported that malignant tumors occur more frequently in patients with myasthenia gravis with concurrent thymoma.
  • Therefore, such patients need to be followed closely for a long period of time for any possible malignant tumor occurring in different organs.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / surgery. Lung Neoplasms / surgery. Myasthenia Gravis / complications. Pneumonectomy / methods. Thymectomy

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  • (PMID = 17352181.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
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2. Yamaguchi Y, Ishii G, Kojima M, Yoh K, Otsuka H, Otaki Y, Aokage K, Yanagi S, Nagai K, Nishiwaki Y, Ochiai A: Histopathologic features of the tumor budding in adenocarcinoma of the lung: tumor budding as an index to predict the potential aggressiveness. J Thorac Oncol; 2010 Sep;5(9):1361-8
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  • [Title] Histopathologic features of the tumor budding in adenocarcinoma of the lung: tumor budding as an index to predict the potential aggressiveness.
  • This morphologic feature is increasingly being recognized as an adverse prognostic factor.
  • The purpose of this study was to evaluate the clinicopathologic significance of tumor budding in adenocarcinomas of the lung.
  • METHODS: We investigated the relationship between tumor budding and clinicopathologic parameters of adenocarcinomas of the lung and the prognostic significance of tumor budding by reviewing the cases of 201 consecutive patients who had undergone complete resection of adenocarcinoma of the lung measuring 30 mm or less in diameter.
  • RESULTS: Tumor budding was observed in 78 (43.1%) of the 181 cases with invasive adenocarcinoma.
  • Examination of the relation between the presence of tumor budding and the predominant histologic subtype revealed that the predominant papillary subtype was significantly associated with the presence of tumor budding (p = 0.0023), whereas the predominant bronchioloalveolar carcinoma subtype was significantly associated with the absence of tumor budding (p < 0.001).
  • Compared with cancer cells forming nests, BCs displayed reduced expression of cellular adhesion molecule, E-cadherin, and beta-catenin (p < 0.05 and p < 0.05, respectively) and increased expression of laminin5-gamma2 (p < 0.05).
  • Multivariate analysis revealed that tumor budding was significant independent prognostic factor of the small-sized adenocarcinoma of the lung.
  • CONCLUSIONS: Our data showed that tumor budding in adenocarcinoma of the lung is a distinct morphologic feature that has biologic and prognostic significance.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma, Bronchiolo-Alveolar / pathology. Biomarkers, Tumor / metabolism. Carcinoma, Papillary / pathology. Lung Neoplasms / pathology. Pleural Neoplasms / pathology
  • [MeSH-minor] Cadherins / metabolism. Cell Adhesion Molecules / metabolism. Follow-Up Studies. Humans. Immunoenzyme Techniques. Lymphatic Metastasis. Neoplasm Invasiveness. Neoplasm Staging. Prognosis. Survival Rate. Tissue Array Analysis. beta Catenin / metabolism

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  • (PMID = 20631633.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins; 0 / Cell Adhesion Molecules; 0 / beta Catenin; 0 / kalinin
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3. Khan S, Ng ML, Tan YJ: Expression of the severe acute respiratory syndrome coronavirus 3a protein and the assembly of coronavirus-like particles in the baculovirus expression system. Methods Mol Biol; 2007;379:35-50
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  • The Bac-to-Bac Baculovirus expression system was used to generate a recombinant baculovirus capable of expressing the severe acute respiratory syndrome (SARS)-coronavirus (CoV) 3a protein.
  • Using the same expression system, two structural proteins, membrane (M) and envelope (E), were co-expressed to form SARS-CoV virus-like particles (VLPs) within an insect cell.
  • [MeSH-minor] Animals. Baculoviridae. Cell Line. Gene Expression. Humans. Spodoptera / cytology

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  • (PMID = 17502669.001).
  • [ISSN] 1064-3745
  • [Journal-full-title] Methods in molecular biology (Clifton, N.J.)
  • [ISO-abbreviation] Methods Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 3a protein, severe acute respiratory syndrome coronavirus; 0 / Recombinant Proteins; 0 / Viral Proteins
  • [Number-of-references] 38
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4. Bubeck SS, Cantwell AM, Dube PH: Delayed inflammatory response to primary pneumonic plague occurs in both outbred and inbred mice. Infect Immun; 2007 Feb;75(2):697-705
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  • Yersinia pestis is the causative agent of plague, a disease that can manifest as either bubonic or pneumonic plague.
  • An interesting feature of plague is that it is a rapidly progressive disease, suggesting that Y. pestis either evades and/or suppresses the innate immune response to infection.
  • A comparative analysis of the course of disease in these two strains of mice indicated that they are susceptible to intranasal Y. pestis CO92 infection and have similar 50% lethal doses and kinetics of infection with respect to colonization of the lung, liver, and spleen.
  • Significantly, in both strains of mice, robust neutrophil recruitment to the lungs was not observed until 48 h after infection, suggesting that there was a delay in inflammatory cell recruitment to the site of infection.
  • In addition, proinflammatory cytokines (interleukin-6 [IL-6], tumor necrosis factor alpha, gamma interferon, IL-12p70, monocyte chemoattractant protein 1) and chemokines (KC, MIP-2) in the bronchoalveolar lavage fluids were not readily detected until 48 h after infection, which coincided with the increase in polymorphonuclear leukocyte (PMN) recruitment to the lungs.
  • In comparison, CD1 mice with gram-negative pneumonia caused by Klebsiella pneumoniae exhibited strong inflammatory responses early in infection, with PMNs comprising the majority of the cells in the bronchoalveolar lavage fluid 24 h postinfection, indicating that PMN recruitment to the lungs could occur earlier in this infection than in Y. pestis infection.
  • [MeSH-major] Cytokines / metabolism. Lung / immunology. Neutrophil Infiltration. Neutrophils / immunology. Plague / immunology. Yersinia pestis / immunology
  • [MeSH-minor] Animals. Bronchoalveolar Lavage Fluid / cytology. Bronchoalveolar Lavage Fluid / immunology. Chemokines / metabolism. Disease Models, Animal. Female. Histocytochemistry. Klebsiella Infections / immunology. Klebsiella pneumoniae / immunology. Lethal Dose 50. Liver / microbiology. Mice. Mice, Inbred C57BL. Spleen / microbiology. Time Factors

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  • (PMID = 17101642.001).
  • [ISSN] 0019-9567
  • [Journal-full-title] Infection and immunity
  • [ISO-abbreviation] Infect. Immun.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chemokines; 0 / Cytokines
  • [Other-IDs] NLM/ PMC1828510
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5. Silvestris N, Di Palma T, Rabitti C, Pericoli MN, Pisani L, D'Aprile M: Rapidly progressive coma in leptomeningeal carcinomatosis from undiagnosed bronchioloalveolar carcinoma. J Clin Oncol; 2009 Aug 20;27(24):e65-6
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  • [Title] Rapidly progressive coma in leptomeningeal carcinomatosis from undiagnosed bronchioloalveolar carcinoma.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / complications. Coma / etiology. Lung Neoplasms / complications. Meningeal Carcinomatosis / complications. Meningeal Carcinomatosis / secondary

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  • (PMID = 19506157.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. Slaney JM, Curtis MA: Mechanisms of evasion of complement by Porphyromonas gingivalis. Front Biosci; 2008 Jan 01;13:188-96
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  • Activation leads to deposition on the bacterial surface of C3b and its' inactivation products and phagocytosis of the opsonised bacteria by host cells.
  • Alternatively the entire complement pathway including terminal components C5b-9 may be activated on the cell surface which gives rise to generation and insertion of the membrane attack complex into the bacterial membrane and cell lysis.
  • Bacterial resistance to complement may be by enzyme digestion of complement components or by the generation or acquisition from the host of cell surface molecules which allow the organism to adopt host complement control proteins.
  • The proteases of Porphyromonas gingivalis breakdown C3 and C5 and prevent the deposition of C3b on the bacterial cell surface.
  • Instead, complement resistance in P. gingivalis is associated with the presence on the cell surface of an anionic branched mannan and appears independent of capsule serotype.
  • [MeSH-major] Cell Membrane / metabolism. Complement System Proteins / physiology. Polysaccharides / metabolism. Porphyromonas gingivalis / metabolism
  • [MeSH-minor] Bacterial Outer Membrane Proteins / metabolism. Complement Activation. Humans. Lipopolysaccharides / chemistry. Models, Biological. O Antigens / chemistry. Phagocytosis. Pseudomonas aeruginosa / metabolism

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  • (PMID = 17981537.001).
  • [ISSN] 1093-9946
  • [Journal-full-title] Frontiers in bioscience : a journal and virtual library
  • [ISO-abbreviation] Front. Biosci.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0501478
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Outer Membrane Proteins; 0 / Lipopolysaccharides; 0 / O Antigens; 0 / Polysaccharides; 9007-36-7 / Complement System Proteins
  • [Number-of-references] 66
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7. Kim TH, Kim SJ, Ryu YH, Chung SY, Seo JS, Kim YJ, Choi BW, Lee SH, Cho SH: Differential CT features of infectious pneumonia versus bronchioloalveolar carcinoma (BAC) mimicking pneumonia. Eur Radiol; 2006 Aug;16(8):1763-8
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  • [Title] Differential CT features of infectious pneumonia versus bronchioloalveolar carcinoma (BAC) mimicking pneumonia.
  • The purpose of this study was to evaluate retrospectively the differential CT features of bronchioloalveolar carcinoma (BAC) mimicking pneumonia and infectious pneumonia at the lung periphery.
  • CT images were reviewed in 47 patients with focal areas of parenchymal opacification at the lung periphery.
  • We evaluated the presence of ground-glass attenuation, marginal conspicuity of the lesion, CT angiogram sign, air-bronchogram sign, a bubble-like low-attenuation area within the lesion, presence of pleural thickening and retraction associated with the lesion, presence of pleural effusion and extra-pleural fatty hypertrophy, presence of bronchial wall thickening proximal to the lesion, and air-trapping in the normal lung near the lesion.
  • BAC (n=18) depicted the presence of a bubble-like low-attenuation area within the lesion, whereas infectious pneumonia (n=29) represented the pleural thickening associated with the lesion and bronchial wall thickening proximal to the lesion (P<0.05).
  • The focal areas of the parenchymal opacification on the CT images may suggest infectious pneumonia rather than BAC when they show bronchial wall thickening proximal to the lesion and pleural thickening associated with the lesion, whereas BAC is characterized as the presence of a bubble-like low attenuation area within the tumor.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnostic imaging. Lung Neoplasms / diagnostic imaging. Pneumonia / diagnostic imaging. Tomography, Spiral Computed / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Contrast Media. Diagnosis, Differential. Female. Humans. Iohexol / analogs & derivatives. Male. Middle Aged. Predictive Value of Tests. Radiography, Thoracic. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 16418864.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article
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8. Gundersen H, Grüner R, Specht K, Hugdahl K: The effects of alcohol intoxication on neuronal activation at different levels of cognitive load. Open Neuroimag J; 2008;2:65-72
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  • The aim of this study was to investigate how alcohol intoxication at two blood alcohol concentrations (BAC) affected neuronal activation during increasing levels of cognitive load.
  • Participants in the control group (N=13) were scanned after drinking a soft-drink at both scanning sessions, while participants in the alcohol group (N=12) were scanned once after drinking an alcoholic beverage resulting in a BAC of 0.02%, and once after drinking an alcoholic beverage resulting in a BAC of 0.08%.
  • A decrease in neuronal activation was seen in the dorsal anterior cingulate cortex (dACC) and in the cerebellum in the alcohol group at the BAC of 0.08% when the participants performed the most demanding task.
  • The results have revealed that the effect of alcohol intoxication on brain activity is dependent on BAC and of cognitive load.

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  • (PMID = 19018317.001).
  • [ISSN] 1874-4400
  • [Journal-full-title] The open neuroimaging journal
  • [ISO-abbreviation] Open Neuroimag J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC2577939
  • [Keywords] NOTNLM ; Alcohol intoxication / brain function / cognitive load / different blood alcohol concentrations
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9. Rogatcheva MB, Chen K, Larkin DM, Meyers SN, Marron BM, He W, Schook LB, Beever JE: Piggy-BACing the human genome I: constructing a porcine BAC physical map through comparative genomics. Anim Biotechnol; 2008;19(1):28-42
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  • [Title] Piggy-BACing the human genome I: constructing a porcine BAC physical map through comparative genomics.
  • Availability of the human genome sequence and high similarity between humans and pigs at the molecular level provides an opportunity to use a comparative mapping approach to piggy-BAC the human genome.
  • In order to advance the pig genome sequencing initiative, sequence similarity between large-scale porcine BAC-end sequences (BESs) and human genome sequence was used to construct a comparatively-anchored porcine physical map that is a first step towards sequencing the pig genome.
  • A total of 50,300 porcine BAC clones were end-sequenced, yielding 76,906 BESs after trimming with an average read length of 538 bp.
  • To anchor the porcine BACs on the human genome, these BESs were subjected to BLAST analysis using the human draft sequence, revealing 31.5% significant hits (E < e(-5)).
  • The strategy of piggy-BACing the human genome described in this study demonstrates that through a directed, targeted comparative genomics approach construction of a high-resolution anchored physical map of the pig genome can be achieved.
  • This map supports the selection of BACs to construct a minimal tiling path for genome sequencing and targeted gap filling.
  • [MeSH-minor] Animals. Chromosome Mapping. Chromosomes, Artificial, Bacterial / genetics. DNA / genetics. DNA / isolation & purification. Genome. Genomic Library. Humans. Nucleic Acid Hybridization

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  • (PMID = 18228174.001).
  • [ISSN] 1532-2378
  • [Journal-full-title] Animal biotechnology
  • [ISO-abbreviation] Anim. Biotechnol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-49-2 / DNA
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10. Liu D, Kojima T, Ouchi M, Kuroda S, Watanabe Y, Hashimoto Y, Onimatsu H, Urata Y, Fujiwara T: Preclinical evaluation of synergistic effect of telomerase-specific oncolytic virotherapy and gemcitabine for human lung cancer. Mol Cancer Ther; 2009 Apr;8(4):980-7
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  • [Title] Preclinical evaluation of synergistic effect of telomerase-specific oncolytic virotherapy and gemcitabine for human lung cancer.
  • The present preclinical study investigates whether OBP-301 and a chemotherapeutic agent that is commonly used for lung cancer treatment, gemcitabine, are able to enhance antitumor effects in vitro and in vivo.
  • In vivo antitumor effects of intratumoral injection of OBP-301 in combination with systemic administration of gemcitabine were assessed on nu/nu mice s.c. xenografted with human lung tumors.
  • OBP-301 infection combined with gemcitabine resulted in very potent synergistic cytotoxicity in human lung cancer cells.
  • The three human lung cancer cell lines treated with OBP-301 for 24 hours tended to accumulate in S phase compared with controls.
  • Intratumoral injection of OBP-301 combined with systemic administration of gemcitabine showed therapeutic synergism in human lung tumor xenografts.
  • Our data suggest that the combination of OBP-301 and gemcitabine enhances the antitumor effects against human lung cancer.
  • We also found that the synergistic mechanism may be due to OBP-301-mediated cell cycle accumulation in S phase.
  • These results have important implications for the treatment of human lung cancer.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / therapy. Antimetabolites, Antineoplastic / therapeutic use. Carcinoma, Large Cell / therapy. Deoxycytidine / analogs & derivatives. Lung Neoplasms / therapy. Oncolytic Virotherapy. Telomerase / metabolism
  • [MeSH-minor] Adenovirus E1A Proteins / metabolism. Animals. Blotting, Western. Cell Proliferation / drug effects. Combined Modality Therapy. Drug Evaluation, Preclinical. Female. Humans. Immunoenzyme Techniques. Mice. Mice, Inbred BALB C. Mice, Nude. Ribonucleotide Reductases / antagonists & inhibitors. S Phase / drug effects. S Phase / physiology. Signal Transduction. Tumor Cells, Cultured. Virus Replication / drug effects. Xenograft Model Antitumor Assays

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  • (PMID = 19372571.001).
  • [ISSN] 1535-7163
  • [Journal-full-title] Molecular cancer therapeutics
  • [ISO-abbreviation] Mol. Cancer Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adenovirus E1A Proteins; 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine; EC 1.17.4.- / Ribonucleotide Reductases; EC 2.7.7.49 / Telomerase
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11. Douglas VC, Tong DC, Gillum LA, Zhao S, Brass LM, Dostal J, Johnston SC: Do the Brain Attack Coalition's criteria for stroke centers improve care for ischemic stroke? Neurology; 2005 Feb 8;64(3):422-7
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  • BACKGROUND: In 2000, the Brain Attack Coalition (BAC) recommended 11 major criteria for the establishment of primary stroke centers.
  • The BAC relied heavily on expert opinion because evidence supporting the criteria was sparse.
  • OBJECTIVE: To assess primary stroke center elements, based on the criteria proposed by the BAC, with a questionnaire at 34 academic medical centers.
  • CONCLUSIONS: Of the 11 stroke center elements recommended by the BAC, 7 were associated with increased tPA use.

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  • (PMID = 15699369.001).
  • [ISSN] 1526-632X
  • [Journal-full-title] Neurology
  • [ISO-abbreviation] Neurology
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS02254
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.4.21.68 / Tissue Plasminogen Activator
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12. Nord H, Hartmann C, Andersson R, Menzel U, Pfeifer S, Piotrowski A, Bogdan A, Kloc W, Sandgren J, Olofsson T, Hesselager G, Blomquist E, Komorowski J, von Deimling A, Bruder CE, Dumanski JP, Díaz de Ståhl T: Characterization of novel and complex genomic aberrations in glioblastoma using a 32K BAC array. Neuro Oncol; 2009 Dec;11(6):803-18
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  • [Title] Characterization of novel and complex genomic aberrations in glioblastoma using a 32K BAC array.
  • Glioblastomas (GBs) are malignant CNS tumors often associated with devastating symptoms.
  • Patients with GB have a very poor prognosis, and despite treatment, most of them die within 12 months from diagnosis.
  • Several pathways, such as the RAS, tumor protein 53 (TP53), and phosphoinositide kinase 3 (PIK3) pathways, as well as the cell cycle control pathway, have been identified to be disrupted in this tumor.
  • In this study, we have applied a 32K clone-based genomic array, covering 99% of the current assembly of the human genome, to the detailed genetic profiling of a set of 78 GBs.
  • Complex patterns of aberrations, including high and narrow copy number amplicons, as well as a number of homozygously deleted loci, were identified.
  • Many of these genes are already linked to several forms of cancer; others represent new candidate genes that may serve as prognostic markers or even as therapeutic targets in the future.
  • The large individual variation observed between the samples demonstrates the underlying complexity of the disease and strengthens the demand for an individualized therapy based on the genetic profile of the patient.
  • [MeSH-major] Brain Neoplasms / genetics. Chromosome Aberrations. Chromosomes, Artificial, Bacterial. Gene Expression Profiling. Genes, Neoplasm. Glioblastoma / genetics


13. Ciesielski S, Cydzik-Kwiatkowska A, Pokoj T, Klimiuk E: Molecular detection and diversity of medium-chain-length polyhydroxyalkanoates-producing bacteria enriched from activated sludge. J Appl Microbiol; 2006 Jul;101(1):190-9
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  • AIMS: Knowledge of the species composition of complex bacterial communities is still very limited.
  • The results of a 16S rDNA sequence analysis revealed that three strains belonged to Pseudomonas species and the fourth one was characterized as Comamonas testosteroni.
  • The results of a comparative phylogenetic analysis revealed that mcl-PHA-synthesizing bacteria can be divided into Pseudomonas fluorescens and Pseudomonas aeruginosa groups.
  • [MeSH-major] Bacteria / genetics. DNA, Bacterial / analysis. Ecosystem. Genetic Variation. Water Microbiology

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  • (PMID = 16834606.001).
  • [ISSN] 1364-5072
  • [Journal-full-title] Journal of applied microbiology
  • [ISO-abbreviation] J. Appl. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Bacterial; EC 2.3.- / Acyltransferases; EC 2.3.1.- / poly(3-hydroxyalkanoic acid) synthase; Y4S76JWI15 / Methanol
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14. Mömke S, Drögemüller C, Distl O: A high-resolution radiation hybrid map of bovine chromosome 5q1.3-q2.5 compared with human chromosome 12q. Anim Genet; 2005 Jun;36(3):248-53
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  • In this study we present a comprehensive 3000-rad radiation hybrid map on bovine chromosome 5 (BTA5) of a region between 12.8 and 74.0 cM according to the linkage map, which contains a quantitative trait loci for ovulation rate.
  • We mapped 28 gene-associated sequence tagged site markers derived from sequences of bovine BAC clones and 10 microsatellite markers to the BTA5 region.

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  • (PMID = 15932408.001).
  • [ISSN] 0268-9146
  • [Journal-full-title] Animal genetics
  • [ISO-abbreviation] Anim. Genet.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA Primers
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15. Xia Z, Watanabe S, Chen Q, Sato S, Harada K: A novel manual pooling system for preparing three-dimensional pools of a deep coverage soybean bacterial artificial chromosome library. Mol Ecol Resour; 2009 Mar;9(2):516-24
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  • [Title] A novel manual pooling system for preparing three-dimensional pools of a deep coverage soybean bacterial artificial chromosome library.
  • It is time-consuming and labourious to prepare three-dimensional pools for a deep coverage bacterial artificial chromosome (BAC) library of soybean (1.12 × 10(9)  bp) in the absence of robotic facility.
  • In the present study, we describe a novel manual pooling system for preparing three-dimensional pools of a soybean BAC library.
  • This simple technique enables a single researcher to construct three-dimensional pools for a deep-coverage (12 haploid genome equivalents) BAC library of soybean in less than 2 months without any robotic manipulation.
  • This efficient pooling system could be applied to any other BAC libraries without the need for robotic manipulation.

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  • [Copyright] © 2009 The Authors. Journal compilation © 2009 Blackwell Publishing Ltd.
  • (PMID = 21564681.001).
  • [ISSN] 1755-098X
  • [Journal-full-title] Molecular ecology resources
  • [ISO-abbreviation] Mol Ecol Resour
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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16. Hien NT, Ushijima H: Frequency of prenatal care visits by ethnic minority mothers and association with infant birthweight in Bac Kan Province, Vietnam. Trop Doct; 2005 Apr;35(2):103-4
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  • [Title] Frequency of prenatal care visits by ethnic minority mothers and association with infant birthweight in Bac Kan Province, Vietnam.
  • The objective of this cross-sectional study was to evaluate the association between prenatal care visits and infant birthweight among ethnic minority mothers in the mountainous Bac Kan province.
  • The frequency of prenatal care visit are probably associated with a decreased risk of LBW among ethnic minority mothers in Bac Kan province.

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  • (PMID = 15970037.001).
  • [ISSN] 0049-4755
  • [Journal-full-title] Tropical doctor
  • [ISO-abbreviation] Trop Doct
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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17. De Preter K, Menten B, De Brouwer S, Kumps C, Michels E, Van Roy N, Vandesompele J, Speleman F: Low-cost dedicated mini-arrays for high-throughput analysis of DNA copy-number alterations in neuroblastoma. Cancer Lett; 2008 Sep 28;269(1):111-6
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  • For this purpose, we have constructed a dedicated mini-array that is enriched for BAC/PAC clones in the prognostic important regions for neuroblastoma and that only covers a small area on the slide, allowing down-scaling of the labelling and hybridisation reagents and hence reducing the price.

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  • (PMID = 18555593.001).
  • [ISSN] 1872-7980
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
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18. McMillan D, Miethke P, Alsop AE, Rens W, O'Brien P, Trifonov V, Veyrunes F, Schatzkamer K, Kremitzki CL, Graves T, Warren W, Grützner F, Ferguson-Smith MA, Graves JA: Characterizing the chromosomes of the platypus (Ornithorhynchus anatinus). Chromosome Res; 2007;15(8):961-74
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  • Like the unique platypus itself, the platypus genome is extraordinary because of its complex sex chromosome system, and is controversial because of difficulties in identification of small autosomes and sex chromosomes.
  • We have established an agreed nomenclature and identified anchor BAC clones for each chromosome that will ensure unambiguous gene localizations.
  • [MeSH-minor] Animals. Cells, Cultured. Chromosome Banding. Chromosome Mapping. Chromosome Painting. Chromosomes, Artificial, Bacterial. Female. Fibroblasts. Genome. In Situ Hybridization, Fluorescence. Karyotyping. Male. Metaphase

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  • (PMID = 18185982.001).
  • [ISSN] 0967-3849
  • [Journal-full-title] Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology
  • [ISO-abbreviation] Chromosome Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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19. Kim Y, Kim HS, Cui ZY, Lee HS, Ahn JS, Park CK, Park K, Ahn MJ: Clinicopathological implications of EpCAM expression in adenocarcinoma of the lung. Anticancer Res; 2009 May;29(5):1817-22
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  • [Title] Clinicopathological implications of EpCAM expression in adenocarcinoma of the lung.
  • BACKGROUND: The frequency of epithelial cell adhesion molecule (EpCAM) expression was investigated in non-small cell lung cancer (NSCLC) cells and human tissues, and its clinicopathological significance in adenocarcinoma of the lung was evaluated.
  • MATERIALS AND METHODS: EpCAM expression was analysed by reverse transcription-polymerase chain reaction (RT-PCR) and flow cytometry in human NSCLC cells.
  • EpCAM protein expression was evaluated in 234 adenocarcinoma tissues using immunohistochemistry.
  • RESULTS: A high expression level of EpCAM was observed in human NSCLC cells by flow cytometry and RT-PCR.
  • EpCAM overexpression was detected in 120/234 (51.3%) surgically resected adenocarcinoma tissues.
  • EpCAM overexpression occurred significantly more frequently in adenocarcinoma than in bronchioloalveolar carcinoma (p=0.02).
  • CONCLUSION: These findings suggest EpCAM plays a role in the carcinogenesis of adenocarcinoma of the lung and might provide a promising molecule for targeted therapy in NSCLC.
  • [MeSH-major] Adenocarcinoma / metabolism. Antigens, Neoplasm / metabolism. Cell Adhesion Molecules / metabolism. Lung Neoplasms / metabolism
  • [MeSH-minor] Base Sequence. Cell Line, Tumor. DNA Primers. Flow Cytometry. Humans. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 19443410.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Cell Adhesion Molecules; 0 / DNA Primers; 0 / EPCAM protein, human
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20. Buffart TE, Carvalho B, Hopmans E, Brehm V, Kranenbarg EK, Schaaij-Visser TB, Eijk PP, van Grieken NC, Ylstra B, van de Velde CJ, Meijer GA: Gastric cancers in young and elderly patients show different genomic profiles. J Pathol; 2007 Jan;211(1):45-51
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  • Although most gastric cancers occur in elderly patients, a substantial number of cases of this common disease occur in young patients.
  • Gastric cancer is a heterogeneous disease at the genomic level and different patterns of DNA copy number alterations are associated with different clinical behaviour.
  • The aim of the present study was to explore differences in DNA copy number alterations in relation to age of onset of gastric cancer.
  • DNA isolated from 46 paraffin-embedded gastric cancer tissue samples from 17 patients less than 50 years of age [median 43 (21-49) years] and 29 patients greater than or equal to 70 years of age [median 75 (70-83) years] was analysed by genome-wide microarray comparative genomic hybridization (array CGH) using an array of 5000 BAC clones.
  • Gastric cancers of young and old patients belong to groups with different genomic profiles, which likely reflect different pathogenic mechanisms of the disease.
  • [MeSH-major] Carcinoma / genetics. Gene Expression Profiling. Genes, Neoplasm. Oligonucleotide Array Sequence Analysis. Stomach Neoplasms / genetics

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  • [Copyright] Copyright (c) 2006 Pathological Society of Great Britain and Ireland.
  • (PMID = 17117405.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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21. Stipcevic T, Piljac A, Piljac G: Enhanced healing of full-thickness burn wounds using di-rhamnolipid. Burns; 2006 Feb;32(1):24-34
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  • The aim of this study was to investigate the properties of di-rhamnolipid [alpha-L-rhamnopyranosyl-(1-2)-alpha-L-rhamnopyranosyl-3-hydroxydecanoyl-3-hydroxydecanoic acid, also referred to as di-rhamnolipid BAC-3] relating to the process of cutaneous wound healing.

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  • (PMID = 16380213.001).
  • [ISSN] 0305-4179
  • [Journal-full-title] Burns : journal of the International Society for Burn Injuries
  • [ISO-abbreviation] Burns
  • [Language] ENG
  • [Grant] United States / NIAMS NIH HHS / AR / A1 R43 AR44443-01A1; United States / NIAMS NIH HHS / AR / R43 AR044443-01A1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Glycolipids; 0 / Ointments; 0 / rhamnolipid
  • [Other-IDs] NLM/ NIHMS8983; NLM/ PMC1586221
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22. Goidts V, Szamalek JM, de Jong PJ, Cooper DN, Chuzhanova N, Hameister H, Kehrer-Sawatzki H: Independent intrachromosomal recombination events underlie the pericentric inversions of chimpanzee and gorilla chromosomes homologous to human chromosome 16. Genome Res; 2005 Sep;15(9):1232-42
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  • The p- and q-arm breakpoints of the inversions in PTR XVI and GGO XVI were found to occur at slightly different locations, consistent with their independent origin.
  • Further, FISH studies of the homologous chromosomal regions in macaque and orangutan revealed that the region represented by HSA BAC RP11-696P19, which spans the inversion breakpoint on HSA 16q11-12, was derived from the ancestral primate chromosome homologous to HSA 1.
  • [MeSH-minor] Animals. Base Sequence. Biological Evolution. Cell Line. Chromosome Breakage. Chromosomes, Artificial, Bacterial / genetics. DNA / genetics. Humans. In Situ Hybridization, Fluorescence. Models, Genetic. Molecular Sequence Data. Species Specificity

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  • (PMID = 16140991.001).
  • [ISSN] 1088-9051
  • [Journal-full-title] Genome research
  • [ISO-abbreviation] Genome Res.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ AY822675/ AY822676/ AY822677
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-49-2 / DNA
  • [Other-IDs] NLM/ PMC1199537
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23. Braun RJ, Kinkl N, Zischka H, Ueffing M: 16-BAC/SDS-PAGE analysis of membrane proteins of yeast mitochondria purified by free flow electrophoresis. Methods Mol Biol; 2009;528:83-107
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  • [Title] 16-BAC/SDS-PAGE analysis of membrane proteins of yeast mitochondria purified by free flow electrophoresis.
  • Especially the inner membrane comprises a high content of proteins, for example, the protein complexes of the respiratory chain.
  • High-resolution separation and analysis of such membrane proteins, for example, by two-dimensional gel electrophoresis (2-DE), is hampered by their hydrophobicity and tendency for aggregation.
  • Here, we describe the separation of mitochondrial membrane proteins of Saccharomyces cerevisiae by 16-benzyldimethyl-n-hexadecylammonium chloride/sodium dodecyl sulfate polyacrylamide gel electrophoresis (16-BAC/SDS-PAGE).
  • This method enables the separation of membrane proteins owing to the solubilizing power of the ionic detergents 16-BAC and SDS, respectively.
  • Subsequently, membrane proteins from ZE-FFE-purified mitochondria were enriched by carbonate extraction and subjected to 16-BAC/SDS-PAGE.

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  • (PMID = 19153686.001).
  • [ISSN] 1064-3745
  • [Journal-full-title] Methods in molecular biology (Clifton, N.J.)
  • [ISO-abbreviation] Methods Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carbonates; 0 / Fatty Alcohols; 0 / Fluorescent Dyes; 0 / Membrane Proteins; 0 / Quaternary Ammonium Compounds; 0 / Saccharomyces cerevisiae Proteins; 368GB5141J / Sodium Dodecyl Sulfate; 45P3261C7T / sodium carbonate; 7UI0TKC3U5 / Ruthenium; 85474O1N9D / cetalkonium chloride
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24. Xiong Z, Kim JS, Pires JC: Integration of genetic, physical, and cytogenetic maps for Brassica rapa chromosome A7. Cytogenet Genome Res; 2010 Jul;129(1-3):190-8
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  • Bacterial artificial chromosome (BAC) contigs have been genetically mapped to the 10 linkage groups of Brassica rapa by BAC end sequences (BES).
  • To integrate the genetic, physical, and cytogenetic maps, fluorescence in situ hybridization (FISH) was used to anchor the assembly of BAC contigs onto Brassica chromosomes using representative BACs.
  • This BAC-FISH approach can be used to identify chromosome arms on separate mitotic metaphase chromosomes or to map multiple BACs to single long pachytene chromosomes.
  • As part of an international consortium that is sequencing the B. rapa genome, we integrated the linkage and physical maps with the B. rapa cytogenetic map for chromosome A7 by hybridizing BACs to mitotic chromosomes and along the length of pachytene chromosome spreads.
  • A total of 31 BACs that were putatively located on A7 were used as probes for FISH analyses; however, only 19 BACs mapped unambiguously to A7 while the remaining BACs either mapped to other chromosomes or hybridized to multiple locations.
  • We then created a multicolor FISH cocktail of 16 BAC probes to simultaneously hybridize the entire length of the A7 chromosome.
  • We successfully applied the 16 A7 BAC probe mix to B. rapa, B. oleracea, and domesticated and resynthesized genotypes of B. napus to demonstrate that this approach can facilitate studies of genome evolution by integrating the genetic, physical, and cytogenetic maps among closely related species of Brassica.
  • [MeSH-minor] Chromosome Mapping. Chromosomes, Artificial, Bacterial / genetics. Contig Mapping. Genetic Markers. In Situ Hybridization, Fluorescence. Physical Chromosome Mapping

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20628251.001).
  • [ISSN] 1424-859X
  • [Journal-full-title] Cytogenetic and genome research
  • [ISO-abbreviation] Cytogenet. Genome Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Genetic Markers
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25. Kriegova E, Arakelyan A, Fillerova R, Zatloukal J, Mrazek F, Navratilova Z, Kolek V, du Bois RM, Petrek M: PSMB2 and RPL32 are suitable denominators to normalize gene expression profiles in bronchoalveolar cells. BMC Mol Biol; 2008;9:69
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  • [Title] PSMB2 and RPL32 are suitable denominators to normalize gene expression profiles in bronchoalveolar cells.
  • To date, no reference genes have been validated for expression studies of bronchoalveolar (BAL) cells.
  • The aims of this study were to identify gene(s) with stable mRNA expression in BAL cells irrespective of gender, smoking, BAL cellular composition, lung pathology, treatment; and to assess the influence of reference genes on target gene expression data.
  • RESULTS: The mRNA expression of ten housekeeping genes (ACTB, ARF1, CANX, G6PD, GAPDH, GPS1, GNB2L1, PSMB2, PSMD2, RPL32) was investigated by qRT-PCR in BAL cells from 71 subjects across a spectrum of lung diseases.
  • CONCLUSION: PSMB2 and RPL32 are, therefore, suitable reference genes to normalize qRT-PCR in BAL cells in sarcoidosis, and other interstitial lung disease.
  • [MeSH-minor] Adolescent. Adult. Animals. Case-Control Studies. Female. Humans. Lung Diseases / genetics. Male. Middle Aged. RNA, Messenger / analysis. Reference Standards. Reverse Transcriptase Polymerase Chain Reaction / standards. Smoking / genetics

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  • (PMID = 18671841.001).
  • [ISSN] 1471-2199
  • [Journal-full-title] BMC molecular biology
  • [ISO-abbreviation] BMC Mol. Biol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Messenger
  • [Other-IDs] NLM/ PMC2529339
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26. Herbst RS, O'Neill VJ, Fehrenbacher L, Belani CP, Bonomi PD, Hart L, Melnyk O, Ramies D, Lin M, Sandler A: Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancer. J Clin Oncol; 2007 Oct 20;25(30):4743-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancer.
  • PURPOSE: Bevacizumab, a humanized anti-vascular endothelial growth factor monoclonal antibody, and erlotinib, a reversible, orally available epidermal growth factor receptor tyrosine kinase inhibitor, have demonstrated evidence of a survival benefit in the treatment of non-small-cell lung cancer (NSCLC).
  • Although not statistically significant, relative to chemotherapy alone, the risk of disease progression or death was 0.66 (95% CI, 0.38 to 1.16) among patients treated with bevacizumab-chemotherapy and 0.72 (95% CI, 0.42 to 1.23) among patients treated with bevacizumab-erlotinib.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Non-Small-Cell Lung / drug therapy. Lung Neoplasms / drug therapy. Neoplasm Recurrence, Local / drug therapy
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / pathology. Adenocarcinoma, Bronchiolo-Alveolar / drug therapy. Adenocarcinoma, Bronchiolo-Alveolar / pathology. Adult. Aged. Aged, 80 and over. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Humanized. Bevacizumab. Carcinoma, Large Cell / drug therapy. Carcinoma, Large Cell / pathology. Disease-Free Survival. Erlotinib Hydrochloride. Female. Glutamates / administration & dosage. Guanine / administration & dosage. Guanine / analogs & derivatives. Humans. Male. Middle Aged. Neoplasm Staging. Pemetrexed. Quinazolines / administration & dosage. Survival Rate. Taxoids / administration & dosage. Treatment Outcome

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  • (PMID = 17909199.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Glutamates; 0 / Quinazolines; 0 / Taxoids; 04Q9AIZ7NO / Pemetrexed; 15H5577CQD / docetaxel; 2S9ZZM9Q9V / Bevacizumab; 5Z93L87A1R / Guanine; DA87705X9K / Erlotinib Hydrochloride
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27. Kim HK, Choi YS, Kim K, Shim YM, Jeong SY, Lee KS, Kwon OJ, Kim J: Management of ground-glass opacity lesions detected in patients with otherwise operable non-small cell lung cancer. J Thorac Oncol; 2009 Oct;4(10):1242-6
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  • [Title] Management of ground-glass opacity lesions detected in patients with otherwise operable non-small cell lung cancer.
  • INTRODUCTION: When pure ground-glass opacity (GGO) lesions are detected in patients with otherwise operable non-small cell lung cancer, it is controversial whether to resect them simultaneously with the primary tumor or not.
  • METHODS: We retrospectively reviewed radiologic features and pathologic diagnoses of pure GGO lesions detected in otherwise operable non-small cell lung cancer.
  • Four of the eight lesions that were simultaneously resected at surgery for the primary tumor turned out to be malignant.
  • All the lesions were divided into nonmalignant (n = 32) and malignant groups (n = 8), and their clinical and radiologic features were compared.
  • Median size of the lesions in the nonmalignant group (5 mm) was significantly smaller than in the malignant group (11 mm) (p = 0.001).
  • We tried to predict whether a lesion is benign or malignant based on its size.
  • CONCLUSIONS: When a pure GGO is detected in otherwise operable lung cancer, it should be resected to rule out the possibility of malignancy if the size is greater than 8 mm.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / pathology. Carcinoma, Non-Small-Cell Lung / radiography. Lung Neoplasms / pathology. Lung Neoplasms / radiography
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / radiography. Adenocarcinoma / surgery. Adenocarcinoma, Bronchiolo-Alveolar / pathology. Adenocarcinoma, Bronchiolo-Alveolar / radiography. Adenocarcinoma, Bronchiolo-Alveolar / surgery. Adult. Aged. Carcinoma, Adenosquamous / pathology. Carcinoma, Adenosquamous / radiography. Carcinoma, Adenosquamous / surgery. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / radiography. Carcinoma, Squamous Cell / surgery. Female. Humans. Male. Middle Aged. Neoplasm Staging. Radiography, Interventional. Retrospective Studies. Sensitivity and Specificity. Survival Rate. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19687762.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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28. Zhang J, Liang ZY, Zeng X, Wu SF, Gao J, Liu TH: [Detection of epidermal growth factor receptor gene mutations in non-small cell lung cancers by real-time polymerase chain reaction using scorpion amplification refractory mutation system]. Zhonghua Bing Li Xue Za Zhi; 2008 May;37(5):294-9
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  • [Title] [Detection of epidermal growth factor receptor gene mutations in non-small cell lung cancers by real-time polymerase chain reaction using scorpion amplification refractory mutation system].
  • OBJECTIVE: To investigate mutations of EGFR gene in non-small cell lung cancers (NSCLC) using scorpions amplification refractory mutation system (Scorpions ARMS) is in comparing the detection sensitivity with that by PCR-direct sequencing method, and in addition to study the correlation between the mutations and the clinicopathological characteristics of the patients.
  • METHODS: Tumor cells were collected by microdissection from paraffin embedded tumor specimens and adjacent normal lung tissues of 82 NSCLC patients.
  • Mutations were more common in female, non-smoking patients with adenocarcinoma and bronchioloalveolar carcinoma histology.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / genetics. Codon / genetics. Exons / genetics. Genes, erbB-1 / genetics. Lung Neoplasms / genetics. Receptor, Epidermal Growth Factor / genetics. Scorpion Venoms / chemistry
  • [MeSH-minor] Adenocarcinoma / genetics. Female. Gene Amplification. Humans. Mutation. Point Mutation. Polymerase Chain Reaction / methods. Sensitivity and Specificity. Sequence Deletion

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  • (PMID = 18956645.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Codon; 0 / Scorpion Venoms; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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29. Shahin H, Gopinath SP, Robertson CS: Influence of alcohol on early Glasgow Coma Scale in head-injured patients. J Trauma; 2010 Nov;69(5):1176-81; discussion 1181
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  • The remaining 188 patients were further divided into an intoxicated group (blood alcohol concentration [BAC] ≥ 0.08%, n = 100 [53%]) and a nonintoxicated group (BAC <0.08%, n = 88 [47%]).
  • To assess whether these results were directly related to the BAC%, piecewise regression using a general linear model was used to assess the intercept and slope of alcohol on the changes of GCS with cutting point at BAC% = 0.08.
  • But in the intoxicated range, BAC% was significantly positively related to the changes of GCS.

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  • (PMID = 21068620.001).
  • [ISSN] 1529-8809
  • [Journal-full-title] The Journal of trauma
  • [ISO-abbreviation] J Trauma
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / P01 NS038660; United States / NINDS NIH HHS / NS / P01 NS038660-10S1; United States / NINDS NIH HHS / NS / P01-NS38660
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS366060; NLM/ PMC3485579
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30. Stuster J: Validation of the standardized field sobriety test battery at 0.08% blood alcohol concentration. Hum Factors; 2006;48(3):608-14
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  • OBJECTIVE: A field study was conducted to evaluate the accuracy of the Standardized Field Sobriety Test (SFST) battery to assist officers in making arrest decisions at blood alcohol concentrations (BACs) below 0.10%.
  • BACKGROUND: The SFST Battery was validated at 0.10% BAC in 1981, but since then many states have reduced statutory limits for driving while intoxicated to 0.08% BAC.
  • RESULTS: Overall, officers' decisions were correct in more than 91% of the cases at the 0.08% BAC level.
  • CONCLUSION: The results of this study provide evidence of the validity of the SFST Battery as an accurate and reliable decision aid for discriminating between BACs above and below 0.08%.
  • [MeSH-major] Alcoholic Intoxication / diagnosis. Automobile Driving. Police

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  • (PMID = 17063973.001).
  • [ISSN] 0018-7208
  • [Journal-full-title] Human factors
  • [ISO-abbreviation] Hum Factors
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Validation Studies
  • [Publication-country] United States
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31. Sakuma Y, Matsukuma S, Yoshihara M, Nakamura Y, Nakayama H, Kameda Y, Tsuchiya E, Miyagi Y: Epidermal growth factor receptor gene mutations in atypical adenomatous hyperplasias of the lung. Mod Pathol; 2007 Sep;20(9):967-73
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  • [Title] Epidermal growth factor receptor gene mutations in atypical adenomatous hyperplasias of the lung.
  • Activating epidermal growth factor receptor (EGFR) gene mutations are frequently detected in lung adenocarcinomas, especially adenocarcinomas with a nonmucinous bronchioloalveolar carcinoma component.
  • EGFR-mutated lung adenocarcinomas respond well to EGFR tyrosine kinase inhibitors.
  • We previously found that most (88%) pure nonmucinous bronchioloalveolar carcinomas (adenocarcinoma in situ) already harbor EGFR mutations, indicating that the mutations are an early genetic event in the pathogenesis.
  • We examined 54 atypical adenomatous hyperplasias, precursor lesions of lung adenocarcinomas, obtained from 28 Japanese patients for the hotspot mutations of EGFR exons 19 and 21 and K-ras codon 12.
  • As EGFR mutational frequency of atypical adenomatous hyperplasias was much lower than that of nonmucinous bronchioloalveolar carcinomas, we surmise that EGFR-mutated atypical adenomatous hyperplasias, but not atypical adenomatous hyperplasias with wild-type EGFR, are likely to progress to nonmucinous bronchioloalveolar carcinomas.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / genetics. Adenomatosis, Pulmonary / genetics. Gene Expression Regulation, Neoplastic. Lung Neoplasms / genetics. Mutation. Receptor, Epidermal Growth Factor / genetics
  • [MeSH-minor] Adult. Aged. Asian Continental Ancestry Group / genetics. Codon. DNA Mutational Analysis. Disease Progression. Exons. Female. Genes, ras. Humans. Hyperplasia. Japan. Male. Middle Aged

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  • (PMID = 17618248.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Codon; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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32. Oda S, Awai K, Liu D, Nakaura T, Yanaga Y, Nomori H, Yamashita Y: Ground-glass opacities on thin-section helical CT: differentiation between bronchioloalveolar carcinoma and atypical adenomatous hyperplasia. AJR Am J Roentgenol; 2008 May;190(5):1363-8
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  • [Title] Ground-glass opacities on thin-section helical CT: differentiation between bronchioloalveolar carcinoma and atypical adenomatous hyperplasia.
  • OBJECTIVE: The purpose of our study was to investigate the differentiation between bronchioloalveolar carcinoma and atypical adenomatous hyperplasia manifesting pure ground-glass opacity (GGO) based on selected features on thin-section helical CT scans.
  • MATERIALS AND METHODS: We evaluated 35 bronchioloalveolar carcinomas and 17 atypical adenomatous hyperplasias that were histologically confirmed and that manifested pure GGO on thin-section helical CT scans.
  • CT findings of atypical adenomatous hyperplasia and bronchioloalveolar carcinoma were compared using univariate and multivariate logistic regression analysis; the odds ratio was computed using the atypical adenomatous hyperplasia group as the reference group.
  • RESULTS: By univariate analysis, the patient age, nodular maximum diameter, mean attenuation value, and findings of an internal air bronchogram were statistically significantly associated with bronchioloalveolar carcinoma (odds ratio [OR] = 1.10 [p = 0.012], OR = 1.27 [p < 0.01], OR = 1.01 [p = 0.023], and OR = 25.30 [p < 0.001], respectively), and sphericity was significantly associated with atypical adenomatous hyperplasia (OR = 0.059, p < 0.001).
  • By multivariate analysis, sphericity was significantly associated with atypical adenomatous hyperplasia (OR = 0.125, p = 0.042) and findings of an internal air bronchogram were associated with bronchioloalveolar carcinoma (OR = 16.10, p = 0.007).
  • CONCLUSION: Nodular sphericity and an internal air bronchogram were useful at thin-section helical CT performed to differentiate between bronchioloalveolar carcinoma and atypical adenomatous hyperplasia.
  • Interobserver agreement was high for each finding.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / radiography. Lung Neoplasms / radiography. Solitary Pulmonary Nodule / radiography. Tomography, Spiral Computed
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Hyperplasia / radiography. Male. Middle Aged. Observer Variation. Retrospective Studies

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  • (PMID = 18430856.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Hajirasouliha I, Hormozdiari F, Sahinalp SC, Birol I: Optimal pooling for genome re-sequencing with ultra-high-throughput short-read technologies. Bioinformatics; 2008 Jul 1;24(13):i32-40
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  • In this article, we focus on re-sequencing experiments using the Solexa technology, based on bacterial artificial chromosome (BAC) clones, and address an experimental design problem.
  • In these specific experiments, approximate coordinates of the BACs on a reference genome are known, and fine-scale differences between the BAC sequences and the reference are of interest.
  • The high-throughput characteristics of the sequencing technology makes it possible to multiplex BAC sequencing experiments by pooling BACs for a cost-effective operation.
  • However, the way BACs are pooled in such re-sequencing experiments has an effect on the downstream analysis of the generated data, mostly due to subsequences common to multiple BACs.
  • [MeSH-major] Algorithms. Chromosome Mapping / methods. Chromosomes, Artificial, Bacterial / genetics. Sequence Alignment / methods. Sequence Analysis, DNA / methods

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  • (PMID = 18586730.001).
  • [ISSN] 1367-4811
  • [Journal-full-title] Bioinformatics (Oxford, England)
  • [ISO-abbreviation] Bioinformatics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2718651
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34. Kramer ML: A new multiphasic buffer system for benzyldimethyl-n-hexadecylammonium chloride polyacrylamide gel electrophoresis of proteins providing efficient stacking. Electrophoresis; 2006 Feb;27(2):347-56
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  • Acidic PAGE systems using cationic detergents such as benzyldimethyl-n-hexadecylammonium chloride (16-BAC) or CTAB have proven useful for the detection of methoxy esters sensitive to alkaline pH, resolving basic proteins such as histones and membrane proteins.
  • Therefore, a new 16-BAC PAGE system based on the theory of moving boundary electrophoresis with properties comparable to the classical SDS-PAGE system was designed.
  • As a result a new multiphasic analytical 16-BAC PAGE system providing efficient stacking and significantly shorter running times is presented here.
  • Furthermore, the concentration of 16-BAC was optimized by determining its previously unknown CMC.

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  • (PMID = 16331586.001).
  • [ISSN] 0173-0835
  • [Journal-full-title] Electrophoresis
  • [ISO-abbreviation] Electrophoresis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Buffers; 0 / Coloring Agents; 0 / Detergents; 0 / Fatty Alcohols; 0 / Proteins; 0 / Quaternary Ammonium Compounds; 0 / alpha-Synuclein; 85474O1N9D / cetalkonium chloride
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35. Lai JM, Chang JT, Wen CL, Hsu SL: Emodin induces a reactive oxygen species-dependent and ATM-p53-Bax mediated cytotoxicity in lung cancer cells. Eur J Pharmacol; 2009 Nov 25;623(1-3):1-9
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  • [Title] Emodin induces a reactive oxygen species-dependent and ATM-p53-Bax mediated cytotoxicity in lung cancer cells.
  • Here, we demonstrate that emodin induces apoptosis in human lung adenocarcinoma A549 cells by activating a reactive oxygen species-elicited ATM-p53-Bax signaling pathway.
  • Co-treating cells with either a p53 inhibitor or respectively knocking down the expression of p53 and Bax by shRNA extensively diminished emodin-induced cell viability, caspase 3 activation and the release of cytochrome c from the mitochondria, indicating the crucial role for p53/Bax in emodin-mediated cytotoxicity.
  • Taken together, our results demonstrate that emodin-induced reactive oxygen species generation activates an ATM-p53-Bax-dependent signaling pathway, which consequently leads to mitochondria-dependent apoptotic cell death in human lung adenocarcinoma A549 cells.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Cell Cycle Proteins / metabolism. Cell Survival / drug effects. DNA-Binding Proteins / metabolism. Emodin / pharmacology. Protein-Serine-Threonine Kinases / metabolism. Reactive Oxygen Species / metabolism. Tumor Suppressor Protein p53 / metabolism. Tumor Suppressor Proteins / metabolism. bcl-2-Associated X Protein / metabolism
  • [MeSH-minor] Adenocarcinoma, Bronchiolo-Alveolar / enzymology. Adenocarcinoma, Bronchiolo-Alveolar / metabolism. Apoptosis / drug effects. Ataxia Telangiectasia Mutated Proteins. Caspase 3 / metabolism. Cell Line, Tumor. Enzyme Activation / drug effects. Humans. Inhibitor of Apoptosis Proteins. Microtubule-Associated Proteins / genetics. Microtubule-Associated Proteins / metabolism. Mitochondria / drug effects. Mitochondria / enzymology. Mitochondria / metabolism. Phosphorylation / drug effects. RNA Interference. Signal Transduction / drug effects

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  • (PMID = 19744477.001).
  • [ISSN] 1879-0712
  • [Journal-full-title] European journal of pharmacology
  • [ISO-abbreviation] Eur. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / BIRC5 protein, human; 0 / Cell Cycle Proteins; 0 / DNA-Binding Proteins; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins; 0 / Reactive Oxygen Species; 0 / Tumor Suppressor Protein p53; 0 / Tumor Suppressor Proteins; 0 / bcl-2-Associated X Protein; EC 2.7.11.1 / ATM protein, human; EC 2.7.11.1 / Ataxia Telangiectasia Mutated Proteins; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 3.4.22.- / Caspase 3; KA46RNI6HN / Emodin
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36. Gunn SR, Bolla AR, Barron LL, Gorre ME, Mohammed MS, Bahler DW, Mellink CH, van Oers MH, Keating MJ, Ferrajoli A, Coombes KR, Abruzzo LV, Robetorye RS: Array CGH analysis of chronic lymphocytic leukemia reveals frequent cryptic monoallelic and biallelic deletions of chromosome 22q11 that include the PRAME gene. Leuk Res; 2009 Sep;33(9):1276-81
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  • We used BAC array-based CGH to detect genomic imbalances in 187 CLL cases.
  • [MeSH-major] Alleles. Antigens, Neoplasm / genetics. Chromosome Deletion. Chromosomes, Human, Pair 22. Leukemia, Lymphocytic, Chronic, B-Cell / genetics. Nucleic Acid Hybridization

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  • (PMID = 19027161.001).
  • [ISSN] 1873-5835
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / PRAME protein, human
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37. Perham N, Moore SC, Shepherd J, Cusens B: Identifying drunkenness in the night-time economy. Addiction; 2007 Mar;102(3):377-80
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  • AIMS: To assess the relationship between blood alcohol concentration (BAC) and indicators used in field sobriety tests putatively associated with intoxication.
  • Breath analysis was used to determine respondents' BAC.
  • FINDINGS: Combinations of slurred speech, staggering gait and glazed eyes significantly predicted levels of BAC with a staggering gait indicating highest levels of intoxication.
  • CONCLUSIONS: Subjective ratings of drunkenness by trained observers corresponded with BAC.
  • Transition BACs denoting observable behaviour change associated with intoxication have been identified.
  • [MeSH-major] Alcoholic Intoxication / diagnosis

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  • (PMID = 17298644.001).
  • [ISSN] 0965-2140
  • [Journal-full-title] Addiction (Abingdon, England)
  • [ISO-abbreviation] Addiction
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 3K9958V90M / Ethanol
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38. Shi G, Wu X, Xiong F, Zhou Y, Liu Z, Deng J, Chen H: [A successive three-step 'Gap-repair' method to generate the mWAP-hLF hybrid gene locus]. Sheng Wu Gong Cheng Xue Bao; 2008 Sep;24(9):1538-44
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  • Then using 'Gap-repair 'method mediated by Red recombination system of lambda-prophage in Escherichia coli, in the first step, the 8 kb 3' flanking region of the mWAP gene was subcloned from the Bacterial artificial chromosome which harbors the mWAP gene locus(mWAP BAC) into the gap-repair vector; in the second step, the 29 kb hLF genomic sequence from the ATG code to the TAA code was subcloned from the hLF BAC; in the third step, the 12 kb 5' flanking region of the mWAP gene was subcloned from the mWAP BAC.

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  • (PMID = 19160834.001).
  • [ISSN] 1000-3061
  • [Journal-full-title] Sheng wu gong cheng xue bao = Chinese journal of biotechnology
  • [ISO-abbreviation] Sheng Wu Gong Cheng Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Milk Proteins; 0 / whey acidic proteins; EC 3.4.21.- / Lactoferrin
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39. Andrieux J: [Array-CGH for routine diagnosis of cryptic chromosomal imbalances]. Pathol Biol (Paris); 2008 Sep;56(6):368-74
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  • [Title] [Array-CGH for routine diagnosis of cryptic chromosomal imbalances].
  • [Transliterated title] Puces à ADN (CGH-array) : application pour le diagnostic de déséquilibres cytogénétiques cryptiques.
  • BAC/PAC and oligonucleotides array-CGH have transformed the field of genetics and are useful for constitutional, hematological and solid tumors cytogenetics.
  • [MeSH-major] Chromosome Disorders / diagnosis. Molecular Diagnostic Techniques / methods. Nucleic Acid Hybridization / methods. Oligonucleotide Array Sequence Analysis
  • [MeSH-minor] Chromosomes, Artificial, Bacterial / genetics. Gene Dosage. Genetic Testing / methods. Humans. Karyotyping / methods. Molecular Weight. Oligonucleotide Probes

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  • (PMID = 18514435.001).
  • [ISSN] 0369-8114
  • [Journal-full-title] Pathologie-biologie
  • [ISO-abbreviation] Pathol. Biol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Oligonucleotide Probes
  • [Number-of-references] 82
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40. Bhatt S, Moradkhani K, Mrasek K, Puechberty J, Lefort G, Lespinasse J, Sarda P, Liehr T, Hamamah S, Pellestor F: Breakpoint characterization: a new approach for segregation analysis of paracentric inversion in human sperm. Mol Hum Reprod; 2007 Oct;13(10):751-6
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  • In order to improve the assessment of meiotic segregation in PAI, we present a new strategy based on the use of bacterial artificial chromosome (BAC) probes which allow a precise localization of chromosome breakpoints and the identification of all meiotic products in human sperm.

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  • (PMID = 17913851.001).
  • [ISSN] 1360-9947
  • [Journal-full-title] Molecular human reproduction
  • [ISO-abbreviation] Mol. Hum. Reprod.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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41. Calafat A, Juan M, Duch MA: Preventive interventions in nightlife: a review. Adicciones; 2009;21(4):387-413
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  • 'Classical' measures (taxation, reduced BAC limits, minimum legal purchasing age...) are also evidence-based and effective.

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  • (PMID = 20011993.001).
  • [ISSN] 0214-4840
  • [Journal-full-title] Adicciones
  • [ISO-abbreviation] Adicciones
  • [Language] eng; spa
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Spain
  • [Number-of-references] 103
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42. Yin BL, Guo L, Zhang DF, Terzaghi W, Wang XF, Liu TT, He H, Cheng ZK, Deng XW: Integration of cytological features with molecular and epigenetic properties of rice chromosome 4. Mol Plant; 2008 Sep;1(5):816-29
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  • Fluorescence in-situ hybridization (FISH) experiments using a set of bacterial artificial chromosome (BAC) clones from chromosome 4 placed all 18 clones in the region predicted by the model.
  • [MeSH-minor] Base Sequence. Chromosomes, Artificial, Bacterial / genetics. DNA Methylation / genetics. DNA Transposable Elements / genetics. Euchromatin / genetics. Genes, Plant. Genetic Loci / genetics. Heterochromatin / genetics. Histones / metabolism. In Situ Hybridization, Fluorescence. Oligonucleotide Array Sequence Analysis. Protein Processing, Post-Translational. RNA, Plant / metabolism. Transcription, Genetic

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  • (PMID = 19825584.001).
  • [ISSN] 1674-2052
  • [Journal-full-title] Molecular plant
  • [ISO-abbreviation] Mol Plant
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA Transposable Elements; 0 / Euchromatin; 0 / Heterochromatin; 0 / Histones; 0 / RNA, Plant
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43. Tang LF, Du LZ, Chen ZM, Zou CC: Levels of matrix metalloproteinase-9 and its inhibitor in bronchoalveolar lavage cells of asthmatic children. Fetal Pediatr Pathol; 2006 Jan-Feb;25(1):1-7
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  • [Title] Levels of matrix metalloproteinase-9 and its inhibitor in bronchoalveolar lavage cells of asthmatic children.
  • The levels of MMP-9 and TIMP-1 in bronchoalveolar lavage (BAL) cells of asthmatic children were measured immunocytochemically.
  • The percentages of eosinophils and mast cells in bronchoalveolar lavage fluid (BALF) of asthmatic children were increased.
  • Levels of MMP-9 and TIMP-1 in BAL cell of asthmatic children were increased significantly at about 30- and 35-fold relative to the controls, respectively.
  • [MeSH-minor] Bronchoalveolar Lavage. Case-Control Studies. Cell Count. Child, Preschool. Eosinophils / chemistry. Eosinophils / pathology. Extracellular Matrix / chemistry. Extracellular Matrix / pathology. Female. Humans. Immunohistochemistry. Infant. Male. Mast Cells / chemistry. Mast Cells / pathology

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  • (PMID = 16754484.001).
  • [ISSN] 1551-3815
  • [Journal-full-title] Fetal and pediatric pathology
  • [ISO-abbreviation] Fetal Pediatr Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tissue Inhibitor of Metalloproteinase-1; EC 3.4.24.35 / Matrix Metalloproteinase 9
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44. Suemitsu R, Takeo S, Matsuzawa H, Yamaguchi M, Momosaki S, Uesugi N: Can a thoracic surgeon identify lymph node metastases during surgery based on their size? Analysis of 844 metastatic and 10,462 nonmetastatic lymph nodes. J Thorac Oncol; 2010 Mar;5(3):349-53
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  • METHODS: The size of dissected lymph node was quantified in a total of 848 nodes with metastasis and 10,462 nodes without metastasis from 454 patients with lung cancer who underwent a pulmonary resection with lymph node dissection.
  • The smaller the lymph node, the less frequently the lymph nodes were metastatic; however, the ratios of nodes smaller than the fifth largest lymph node with metastasis of adenocarcinoma and squamous cell carcinoma were 21.8 to 26.2%, respectively.
  • When the hilar and mediastinal lymph node stations were examined, 1.14 to 4.00% of the lung cancer patients had lymph node metastasis in small lymph node despite having no metastases in the largest and second largest lymph nodes.
  • CONCLUSIONS: The small lymph nodes in the hilar or mediastinal stations frequently had metastases of carcinoma even though largest and second largest lymph nodes were negative for metastases, especially in adenocarcinoma cases.
  • Surgical oncologists should, therefore, perform systemic lymph node dissection, and not sampling, during a pulmonary resection of lung cancer.
  • [MeSH-major] Carcinoma, Large Cell / surgery. Carcinoma, Non-Small-Cell Lung / secondary. Lung Neoplasms / pathology. Lymph Nodes / pathology. Small Cell Lung Carcinoma / secondary
  • [MeSH-minor] Adenocarcinoma / secondary. Adenocarcinoma / surgery. Adenocarcinoma, Bronchiolo-Alveolar / secondary. Adenocarcinoma, Bronchiolo-Alveolar / surgery. Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / surgery. Female. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Mediastinal Neoplasms / secondary. Mediastinal Neoplasms / surgery. Middle Aged. Neoplasm Staging. Prognosis. Survival Rate

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  • (PMID = 20009772.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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45. Bayou N, M'rad R, Belhaj A, Daoud H, Ben Jemaa L, Zemni R, Briault S, Helayem MB, Chaabouni H: De novo balanced translocation t (7;16) (p22.1; p11.2) associated with autistic disorder. J Biomed Biotechnol; 2008;2008:231904
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  • [Title] De novo balanced translocation t (7;16) (p22.1; p11.2) associated with autistic disorder.
  • The high incidence of de novo chromosomal aberrations in a population of persons with autism suggests a causal relationship between certain chromosomal aberrations and the occurrence of isolated idiopathic autism.
  • We report on the clinical and cytogenetic findings in a male patient with autism, no physical abnormalities and a de novo balanced (7;16)(p22.1;p16.2) translocation.
  • FISH with specific RP11-BAC clones mapping near 7p22.1 and 16p11.2 was used to refine the location of the breakpoints.
  • [MeSH-major] Abnormalities, Multiple. Autistic Disorder / genetics. Chromosomes, Human, Pair 16 / ultrastructure. Chromosomes, Human, Pair 7 / ultrastructure. Translocation, Genetic
  • [MeSH-minor] Arachnoid Cysts. Child. Child Behavior Disorders. Chromosome Banding. Chromosome Disorders / genetics. Chromosome Disorders / pathology. Chromosome Disorders / physiopathology. Chromosomes, Artificial, Bacterial. Cisterna Magna / pathology. Humans. In Situ Hybridization, Fluorescence. Karyotyping. Male. Psychomotor Disorders

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  • (PMID = 18475318.001).
  • [ISSN] 1110-7251
  • [Journal-full-title] Journal of biomedicine & biotechnology
  • [ISO-abbreviation] J. Biomed. Biotechnol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2373955
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46. Courtens W, Wuyts W, Scheers S, Van Luijk R, Reyniers E, Rooms L, Ceulemans B, Kooy F, Wauters J: A de novo subterminal trisomy 10p and monosomy 18q in a girl with MCA/MR: case report and review. Eur J Med Genet; 2006 Sep-Oct;49(5):402-13
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  • [Title] A de novo subterminal trisomy 10p and monosomy 18q in a girl with MCA/MR: case report and review.
  • We report on a 3-year-old girl with psychomotor retardation, cardiopathy, strabismus, umbilical hernia, and facial dysmorphism in whom a de novo unbalanced submicroscopic translocation (10p;18q) was found by MLPA (Multiplex Ligation dependent Probe Amplification) and FISH analyses.
  • Additional FISH studies with locus specific RP11 BAC probes and analyses with microsatellites revealed that the translocation resulted in a deletion estimated between 6 and 9 Mb on the maternal chromosome 18 and a subtelomeric 10p duplication of approximately 6.9 Mb.

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  • (PMID = 16488200.001).
  • [ISSN] 1769-7212
  • [Journal-full-title] European journal of medical genetics
  • [ISO-abbreviation] Eur J Med Genet
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 34
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47. Augulyte L, Kliaugaite D, Racys V, Jankunaite D, Zaliauskiene A, Bergqvist PA, Andersson PL: Multivariate analysis of a biologically activated carbon (BAC) system and its efficiency for removing PAHs and aliphatic hydrocarbons from wastewater polluted with petroleum products. J Hazard Mater; 2009 Oct 15;170(1):103-10
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  • [Title] Multivariate analysis of a biologically activated carbon (BAC) system and its efficiency for removing PAHs and aliphatic hydrocarbons from wastewater polluted with petroleum products.
  • The efficiency of a biologically activated carbon system for treating wastewater polluted with petroleum products was examined and the effects of process parameters on its efficacy were evaluated.

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  • (PMID = 19482425.001).
  • [ISSN] 1873-3336
  • [Journal-full-title] Journal of hazardous materials
  • [ISO-abbreviation] J. Hazard. Mater.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Industrial Waste; 0 / Membranes, Artificial; 0 / Petroleum; 0 / Polycyclic Hydrocarbons, Aromatic; 0 / Water Pollutants, Chemical; 7440-44-0 / Carbon
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48. Grabner B, Blaas L, Musteanu M, Hoffmann T, Birbach A, Eferl R, Casanova E: A mouse tool for conditional mutagenesis in ovarian granulosa cells. Genesis; 2010 Oct 1;48(10):612-7
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  • We have expressed the tamoxifen inducible CreER(T)² fusion protein from a Bacterial Artificial Chromosome (BAC) containing the regulatory elements of the hydroxysteroid (17-beta) dehydrogenase 1 (Hsd17b1) gene.
  • [MeSH-minor] Alleles. Animals. Chromosomes, Artificial, Bacterial / genetics. Escherichia coli / genetics. Female. Genes, Reporter. Humans. In Situ Hybridization. Mice. Mice, Transgenic. RNA, Messenger / metabolism. Receptors, Estrogen / genetics. Recombinant Fusion Proteins / biosynthesis. Recombination, Genetic / drug effects. Tamoxifen / pharmacology


49. Datema E, Mueller LA, Buels R, Giovannoni JJ, Visser RG, Stiekema WJ, van Ham RC: Comparative BAC end sequence analysis of tomato and potato reveals overrepresentation of specific gene families in potato. BMC Plant Biol; 2008;8:34
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  • [Title] Comparative BAC end sequence analysis of tomato and potato reveals overrepresentation of specific gene families in potato.
  • This study presents a first genome-wide analysis of these two species, based on two large collections of BAC end sequences representing approximately 19% of the tomato genome and 10% of the potato genome.

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  • (PMID = 18405374.001).
  • [ISSN] 1471-2229
  • [Journal-full-title] BMC plant biology
  • [ISO-abbreviation] BMC Plant Biol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Plant Proteins
  • [Other-IDs] NLM/ PMC2324086
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50. Kiss AJ, Cheng CH: Molecular diversity and genomic organisation of the alpha, beta and gamma eye lens crystallins from the Antarctic toothfish Dissostichus mawsoni. Comp Biochem Physiol Part D Genomics Proteomics; 2008 Jun;3(2):155-71
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  • A preliminary Fingerprinted Contig analysis of clones containing crystallin genes screened from a toothfish BAC library indicated alpha crystallin genes occurred in a single genomic region of ~266 kbp, beta crystallin genes in ~273 kbp, while the gamma crystallin gene family occurred in two separate regions of ~180 and ~296 kbp.

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  • (PMID = 20483216.001).
  • [ISSN] 1878-0407
  • [Journal-full-title] Comparative biochemistry and physiology. Part D, Genomics & proteomics
  • [ISO-abbreviation] Comp. Biochem. Physiol. Part D Genomics Proteomics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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51. Bentivegna A, Milani D, Gervasini C, Castronovo P, Mottadelli F, Manzini S, Colapietro P, Giordano L, Atzeri F, Divizia MT, Uzielli ML, Neri G, Bedeschi MF, Faravelli F, Selicorni A, Larizza L: Rubinstein-Taybi Syndrome: spectrum of CREBBP mutations in Italian patients. BMC Med Genet; 2006;7:77
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  • BACKGROUND: Rubinstein-Taybi Syndrome (RSTS, MIM 180849) is a rare congenital disorder characterized by mental and growth retardation, broad and duplicated distal phalanges of thumbs and halluces, facial dysmorphisms and increased risk of tumors.
  • METHODS: Our study is based on the mutation analysis of CREBBP in 31 Italian RSTS patients using segregation analysis of intragenic microsatellites, BAC FISH and direct sequencing of PCR and RT-PCR fragments.
  • By direct sequencing a total of 14 de novo mutations were identified: 10 truncating (5 frameshift and 5 nonsense), one splice site, and three novel missense mutations.
  • Identification of the p.Asn1978Ser in the healthy mother of a patient also carrying a de novo frameshift mutation, questions the pathogenetic significance of the missense change reported as recurrent mutation.

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  • [ISSN] 1471-2350
  • [Journal-full-title] BMC medical genetics
  • [ISO-abbreviation] BMC Med. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CREBBP protein, human; 0 / Nuclear Localization Signals; EC 2.3.1.48 / CREB-Binding Protein
  • [Other-IDs] NLM/ PMC1626071
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52. Borg K, Bocian E, Bernaciak J, Nowakowska B, Derwińska K, Obersztyn E, Szczałuba K, Smigiel R, Kostyk E, Mazurczak T: [Balanced chromosomal rearrangements resulting in intellectual disability. An analysis of 22 cases with application of CGH and FISH methods]. Med Wieku Rozwoj; 2009 Apr-Jun;13(2):81-93
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  • The abnormal phenotype might be the result of genomic imbalance or aberrant expression caused by direct breakage of a dosage sensitive gene.
  • Molecular karyotyping was performed in all patients using FISH with region-specific BAC clones, high resolution comparative genomic hybridization (HR-CGH) or array CGH (aCGH).
  • Three rearrangements had more complex structure than conventional methods demonstrated.

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  • (PMID = 19837989.001).
  • [Journal-full-title] Medycyna wieku rozwojowego
  • [ISO-abbreviation] Med Wieku Rozwoj
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Poland
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53. Monnot S, Giuliano F, Massol C, Fossoud C, Cossée M, Lambert JC, Karmous-Benailly H: Partial Xp11.23-p11.4 duplication with random X inactivation: clinical report and molecular cytogenetic characterization. Am J Med Genet A; 2008 May 15;146A(10):1325-9
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  • The karyotype completed by cytogenetic analysis with the Whole Chromosome Painting probe of chromosome X revealed a de novo partial duplication of the short arm of an X chromosome.
  • In order to further characterize the duplicated segment, we used a series of BAC probes extending from band Xp11.22 to Xp22.1.
  • BACs from Xp11.23 to Xp11.4 were duplicated.


54. Han HD, Zhou YW, He WJ, Wang DS: [Comparative study on the organic matter removal in polluted raw water by different techniques at integrated pilot plant]. Huan Jing Ke Xue; 2006 Nov;27(11):2251-4
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  • The waterworks that adopted the Grade II source raw water were suggested to use the conventional techniques and seasonal preozonation techniques, while the others were suggested to alternatively select GAC or BAC technique to meet the request of new water quality criterion.

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  • (PMID = 17326435.001).
  • [ISSN] 0250-3301
  • [Journal-full-title] Huan jing ke xue= Huanjing kexue
  • [ISO-abbreviation] Huan Jing Ke Xue
  • [Language] CHI
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Organic Chemicals; 0 / Water Pollutants, Chemical; 16291-96-6 / Charcoal; 66H7ZZK23N / Ozone
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55. Frendewey D, Chernomorsky R, Esau L, Om J, Xue Y, Murphy AJ, Yancopoulos GD, Valenzuela DM: The loss-of-allele assay for ES cell screening and mouse genotyping. Methods Enzymol; 2010;476:295-307
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  • [Title] The loss-of-allele assay for ES cell screening and mouse genotyping.
  • Targeting vectors used to create directed mutations in mouse embryonic stem (ES) cells consist, in their simplest form, of a gene for drug selection flanked by mouse genomic sequences, the so-called homology arms that promote site-directed homologous recombination between the vector and the target gene.
  • The VelociGene method for the creation of targeted mutations in ES cells employs targeting vectors, called BACVecs, that are based on bacterial artificial chromosomes.
  • In a correctly targeted ES cell clone, the LOA assay detects one of the two native alleles (for genes not on the X or Y chromosome), the other allele being disrupted by the targeted modification.
  • We have designed qPCR LOA assays for deletions, insertions, point mutations, domain swaps, conditional, and humanized alleles and have used the insert assays to quantify the copy number of random insertion BAC transgenics.
  • Because of its quantitative precision, specificity, and compatibility with high throughput robotic operations, the LOA assay eliminates bottlenecks in ES cell screening and mouse genotyping and facilitates maximal speed and throughput for knockout mouse production.

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  • [Copyright] Copyright (c) 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20691873.001).
  • [ISSN] 1557-7988
  • [Journal-full-title] Methods in enzymology
  • [ISO-abbreviation] Meth. Enzymol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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56. Nagano N, Nagano Y, Nakano R, Okamoto R, Inoue M: Genetic diversity of the C protein beta-antigen gene and its upstream regions within clonally related groups of type Ia and Ib group B streptococci. Microbiology; 2006 Mar;152(Pt 3):771-8
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  • [Title] Genetic diversity of the C protein beta-antigen gene and its upstream regions within clonally related groups of type Ia and Ib group B streptococci.
  • C protein beta antigen (Bac), a surface protein of group B streptococci (GBS), is known to concurrently bind the Fc portion of IgA and factor H (FH).
  • The authors' previous work has demonstrated that mRNA expression levels show diversity among clonally related strains containing genes (bac) encoding Bac, with high expression noted in invasive strains.
  • In this study, the bac gene and upstream regions containing putative promoters, three ORFs and an IS1381 insertion sequence were characterized.
  • Three invasive strains showed high bac expression levels and did not show any notable mutations except one strain producing Bac that was able to bind FH but not IgA.
  • A deletion of 51 amino acid residues, including part of the Bac IgA-binding region, was identified and hypothesized to contribute to the loss of the IgA-binding ability of this strain.
  • A vaginal strain that showed somewhat higher bac expression levels and produced Bac lacking immunoreactivity contained an 11 bp deletion, which generated a premature termination codon, in the region preceding the IgA-binding region.
  • In another vaginal strain that did not express bac, disruption of the upstream ORFs of the sensor histidine kinase and DNA-binding response regulator, due to frameshift mutations, was noted although it is not known whether these proteins directly affect bac expression levels.
  • An IS1381 insertion into the promoter region was found in another vaginal strain that showed low expression levels and produced Bac with a significantly larger proline-rich repeat region.
  • These results demonstrate considerable genetic diversity of the bac and upstream regions of invasive and noninvasive GBS, which may contribute to the variability of bac expression levels among those strains.
  • [MeSH-major] Antigens, Bacterial / genetics. Antigens, Surface / genetics. Bacterial Proteins / genetics. Genetic Variation. Streptococcus agalactiae / classification. Streptococcus agalactiae / genetics

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  • (PMID = 16514156.001).
  • [ISSN] 1350-0872
  • [Journal-full-title] Microbiology (Reading, England)
  • [ISO-abbreviation] Microbiology (Reading, Engl.)
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ AB121739/ AB221536/ X58470/ X59771
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Bacterial; 0 / Antigens, Surface; 0 / Bacterial Proteins; 0 / Immunoglobulin A; 80295-65-4 / Complement Factor H
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57. Ronen A, Chassidim HS, Gershon P, Parmet Y, Rabinovich A, Bar-Hamburger R, Cassuto Y, Shinar D: The effect of alcohol, THC and their combination on perceived effects, willingness to drive and performance of driving and non-driving tasks. Accid Anal Prev; 2010 Nov;42(6):1855-65
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  • 1) to investigate the effect of alcohol (BAC=0.05%), THC (13 mg) and their combination on driving and non-driving tasks.

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  • [Copyright] 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20728636.001).
  • [ISSN] 1879-2057
  • [Journal-full-title] Accident; analysis and prevention
  • [ISO-abbreviation] Accid Anal Prev
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 3K9958V90M / Ethanol; 7J8897W37S / Dronabinol
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58. Massion PP, Zou Y, Chen H, Jiang A, Coulson P, Amos CI, Wu X, Wistuba I, Wei Q, Shyr Y, Spitz MR: Smoking-related genomic signatures in non-small cell lung cancer. Am J Respir Crit Care Med; 2008 Dec 1;178(11):1164-72
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  • [Title] Smoking-related genomic signatures in non-small cell lung cancer.
  • RATIONALE: Tobacco smoking is responsible for 85% of all lung cancers.
  • To further our understanding of the molecular pathogenesis of lung cancer, we determined whether smoking history leads to the emergence of specific genomic alterations found in non-small cell lung cancer (NSCLC).
  • Tissue sections were microdissected, and DNA was extracted, purified, and labeled by random priming before hybridization onto bacterial artificial chromosome (BAC) arrays.
  • Lung tumors arising from current-smokers had the greatest number of copy number alterations.
  • The genomic regions most significantly associated with smoking were located within 60 regions and were functionally associated with genes controlling the M phase of the cell cycle, the segregation of chromosomes, and the methylation of DNA.
  • CONCLUSIONS: These findings indicate that smoking history leaves a specific genomic signature in the DNA of lung tumors and suggest that these alterations may reflect new molecular pathways to cancer development.

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  • (PMID = 18776155.001).
  • [ISSN] 1535-4970
  • [Journal-full-title] American journal of respiratory and critical care medicine
  • [ISO-abbreviation] Am. J. Respir. Crit. Care Med.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA55769; United States / NCI NIH HHS / CA / CA102353; United States / NCI NIH HHS / CA / CA90949; United States / NCI NIH HHS / CA / CA70907; United States / NCI NIH HHS / CA / P50 CA070907
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2720147
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59. Cuzon VC, Yeh PW, Yanagawa Y, Obata K, Yeh HH: Ethanol consumption during early pregnancy alters the disposition of tangentially migrating GABAergic interneurons in the fetal cortex. J Neurosci; 2008 Feb 20;28(8):1854-64
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  • This ethanol-induced effect was evident in vivo at embryonic day 14.5 (E14.5) in GAD67 knock-in and BAC-Lhx6 embryos, as well as in vitro in isotypic telencephalic slice cocultures obtained from E14.5 embryos exposed to ethanol in utero.
  • Analysis of heterotypic cocultures indicated that both cell-intrinsic and -extrinsic factors contribute to the aberrant migratory profile of MGE-derived cells.
  • [MeSH-major] Cell Movement / drug effects. Cerebral Cortex / drug effects. Cerebral Cortex / embryology. Ethanol / administration & dosage. Interneurons / drug effects. gamma-Aminobutyric Acid / physiology

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  • (PMID = 18287502.001).
  • [ISSN] 1529-2401
  • [Journal-full-title] The Journal of neuroscience : the official journal of the Society for Neuroscience
  • [ISO-abbreviation] J. Neurosci.
  • [Language] eng
  • [Grant] United States / NIAAA NIH HHS / AA / F31 AA014698; United States / NIMH NIH HHS / MH / R01 MH069826
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 3K9958V90M / Ethanol; 56-12-2 / gamma-Aminobutyric Acid
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60. Sone S, Matsumoto T, Honda T, Tsushima K, Takayama F, Hanaoka T, Kondo R, Haniuda M: HRCT features of small peripheral lung carcinomas detected in a low-dose CT screening program. Acad Radiol; 2010 Jan;17(1):75-83
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  • [Title] HRCT features of small peripheral lung carcinomas detected in a low-dose CT screening program.
  • RATIONALE AND OBJECTIVES: To define high-resolution computed tomography (HRCT) features of lung cancers detected by computed tomography (CT) screening according to histopathology and prognosis.
  • METHODS AND MATERIALS: Tumor size, CT value, morphology, and tumor volume doubling time (TVDT) were determined for 10 atypical adenomatous hyperplasias (AAH) and 50 lung cancers followed between 1996 and 1998 to 2007.
  • Focal bronchioloalveolar cell carcinomas (BAC) were denser (mean, -537 HU) than AAH and mostly less dense than -350 HU; all patients remain alive.
  • All 22 adenocarcinomas (ADC) were denser than -450 HU (mean, -186 HU); 6 were problematic and measured >-150HU and >10 mm or had >10 mm of central denser zone (CDZ) (partly solid tumors) or tumor size (solid tumor).
  • Two of four squamous cell carcinomas (SCC) measuring 15 and 10 mm, respectively, were problematic.
  • Two patients with small-cell lung carcinomas (SCLC) measuring 15 and 23 mm, respectively, remain alive.
  • AAH, BAC, ADC, and SCC lesions were in general polygonal in shape.
  • The mean TVDT for AAH, BAC, ADC, SCC, and SCLC was 1278, 557, 466, 212, and 103 days, respectively.
  • [MeSH-major] Body Burden. Lung Neoplasms / radiography. Mass Screening / methods. Radiographic Image Enhancement / methods. Radiography, Thoracic / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 19879779.001).
  • [ISSN] 1878-4046
  • [Journal-full-title] Academic radiology
  • [ISO-abbreviation] Acad Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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61. Murai J, Ikegami D, Okamoto M, Yoshikawa H, Tsumaki N: Insulation of the ubiquitous Rxrb promoter from the cartilage-specific adjacent gene, Col11a2. J Biol Chem; 2008 Oct 10;283(41):27677-87
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  • To examine the function of these elements, we prepared bacterial artificial chromosome (BAC) transgene constructs containing a 142-kb genomic DNA insert with RXRB and COL11A2 sequences in the middle.
  • In transgenic mouse assays, the wild-type BAC transgene partly recapitulated endogenous Rxrb expression patterns.
  • A 507-bp deletion mutation including 11P enhanced the cartilage-specific activity of the RXRB promoter in BAC transgenic mice.
  • [MeSH-minor] Animals. Cell Line, Tumor. Chromosomes, Artificial, Bacterial / genetics. Enhancer Elements, Genetic / genetics. Introns / genetics. Mice. Mice, Transgenic. Mutation. Rats

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  • (PMID = 18682388.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Col11a2 protein, mouse; 0 / Collagen Type XI; 0 / DNA-Binding Proteins; 0 / Rxrb protein, mouse
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62. González VM, Garcia-Mas J, Arús P, Puigdomènech P: Generation of a BAC-based physical map of the melon genome. BMC Genomics; 2010;11:339
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  • [Title] Generation of a BAC-based physical map of the melon genome.
  • Melon has high intra-specific genetic variation, morphologic diversity and a small genome size (450 Mb), which make this species suitable for a great variety of molecular and genetic studies that can lead to the development of tools for breeding varieties of the species.
  • A number of genetic and genomic resources have already been developed, such as several genetic maps and BAC genomic libraries.
  • These tools are essential for the construction of a physical map, a valuable resource for map-based cloning, comparative genomics and assembly of whole genome sequencing data.
  • A BAC-based melon physical map will be a useful tool to help assemble and refine the draft genome data that is being produced.
  • RESULTS: A melon physical map was constructed using a 5.7 x BAC library and a genetic map previously developed in our laboratories.
  • High-information-content fingerprinting (HICF) was carried out on 23,040 BAC clones, digesting with five restriction enzymes and SNaPshot labeling, followed by contig assembly with FPC software.
  • The anchoring of 845 BAC clones to 178 genetic markers (100 RFLPs, 76 SNPs and 2 SSRs) also allowed the genetic positioning of 183 physical map contigs/singletons, representing 55 Mb (12%) of the melon genome, to individual chromosomal loci.
  • CONCLUSIONS: Here we report the construction of the first physical map of a Cucurbitaceae species described so far.
  • The data presented is already helping to improve the quality of the melon genomic sequence available as a result of a project currently being carried out in Spain, adopting a whole genome shotgun approach based on 454 sequencing data.
  • [MeSH-major] Chromosomes, Artificial, Bacterial / genetics. Cucumis melo / genetics. Genome, Plant / genetics. Physical Chromosome Mapping / methods

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  • (PMID = 20509895.001).
  • [ISSN] 1471-2164
  • [Journal-full-title] BMC genomics
  • [ISO-abbreviation] BMC Genomics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2894041
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63. Ma L, Vu GT, Schubert V, Watanabe K, Stein N, Houben A, Schubert I: Synteny between Brachypodium distachyon and Hordeum vulgare as revealed by FISH. Chromosome Res; 2010 Nov;18(7):841-50
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  • Of 13 BAC clones with inserts from different B. distachyon chromosomes, only two belonging to chromosome 1 yielded hybridization signals on a barley metaphase chromosome (on 7HS and 7HL, respectively), confirming synteny between both chromosomes.
  • Two of four Brachypodium sylvaticum BACs spanning a 223-kb interval homologous to the region of barley that harbors a gibberellic-acid-insensitive semi-dwarfing gene, sdw3, hybridized specifically to a central position of B. distachyon chromosome 1 short arm but not to the homologous region of the barley genome.
  • Repeat-free sequences PCR amplified from four non-overlapping barley BACs linked to the core of Sdw3 region yielded signals at distinct positions in the middle of barley chromosome arm 2HS.
  • [MeSH-minor] Chromosomes, Artificial, Bacterial. Chromosomes, Plant / ultrastructure. Genetic Loci. In Situ Hybridization, Fluorescence

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  • (PMID = 21104310.001).
  • [ISSN] 1573-6849
  • [Journal-full-title] Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology
  • [ISO-abbreviation] Chromosome Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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64. Kasper K, Kremling C, Geerling G: [Toxicity of a new moistening agent and preservative in vitro]. Ophthalmologe; 2008 Jun;105(6):557-62
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  • [Title] [Toxicity of a new moistening agent and preservative in vitro].
  • PURPOSE: The use of preservatives such as benzalkonium chloride (BAC) usually increases the toxicity of pharmaceutical tear substitutes.
  • We therefore examined the effect of preserved (cetrimide 0.01%) and unpreserved HPMC (hydroxypropylmethyl cellulose) and HP-guar in dose and time-response experiments in a human corneal and conjunctival epithelial cell culture model.
  • The ATP content was quantified by means of a luminescence-based ATP assay, intracellular esterase activity by double fluorescent viability staining (calcein AM/ethidium homodimer D-1) and cell migration by a colony dispersion assay.
  • [MeSH-major] Cell Movement / drug effects. Cell Survival / drug effects. Cetrimonium Compounds / toxicity. Conjunctiva / drug effects. Contact Lens Solutions / toxicity. Epithelial Cells / drug effects. Epithelium, Corneal / drug effects. Methylcellulose / analogs & derivatives. Ophthalmic Solutions / toxicity. Polymers / toxicity. Polysaccharides / toxicity. Preservatives, Pharmaceutical / toxicity

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  • (PMID = 18214492.001).
  • [ISSN] 0941-293X
  • [Journal-full-title] Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
  • [ISO-abbreviation] Ophthalmologe
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Cetrimonium Compounds; 0 / Contact Lens Solutions; 0 / Ophthalmic Solutions; 0 / Polymers; 0 / Polysaccharides; 0 / Preservatives, Pharmaceutical; 0 / hydroxypropyl guar; 3NXW29V3WO / Hypromellose Derivatives; 75345-27-6 / polyquaternium 1; 8L70Q75FXE / Adenosine Triphosphate; 9004-67-5 / Methylcellulose; EC 3.1.- / Esterases; Z7FF1XKL7A / cetrimonium
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65. Luo SJ, Johnson WE, David VA, Menotti-Raymond M, Stanyon R, Cai QX, Beck T, Yuhki N, Pecon-Slattery J, Smith JL, O'Brien SJ: Development of Y chromosome intraspecific polymorphic markers in the Felidae. J Hered; 2007;98(5):400-13
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  • We were able to identify new male-specific polymorphisms in the domestic cat Felis catus and 6 additional Felidae species with a combination of molecular genetic and cytogenetic approaches including 1) identifying domestic cat male-specific microsatellites from markers generated from a male cat microsatellite-enriched genomic library, a flow-sorted Y cosmid library, or a Y-specific cat bacteria artificial chromosome (BAC) clone, (2) constructing microsatellite-enriched libraries from flow-sorted Y chromosomes isolated directly from focal wildcat species, and (3) screening Y chromosome conserved anchored tagged sequences primers in Felidae species.

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  • (PMID = 17646273.001).
  • [ISSN] 0022-1503
  • [Journal-full-title] The Journal of heredity
  • [ISO-abbreviation] J. Hered.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CO / N01-CO-12400
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers
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66. Van Keuren ML, Gavrilina GB, Filipiak WE, Zeidler MG, Saunders TL: Generating transgenic mice from bacterial artificial chromosomes: transgenesis efficiency, integration and expression outcomes. Transgenic Res; 2009 Oct;18(5):769-85
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  • [Title] Generating transgenic mice from bacterial artificial chromosomes: transgenesis efficiency, integration and expression outcomes.
  • Bacterial artificial chromosome (BAC) transgenes direct gene expression at physiological levels with the same developmental timing and expression patterns as endogenous genes in transgenic animal models.
  • We generated 707 transgenic founders from 86 BAC transgenes purified by three different methods.
  • Transgenesis efficiency was the same for all BAC DNA purification methods.
  • Polyamine microinjection buffer was essential for successful integration of intact BAC transgenes.
  • There was no correlation between BAC size and transgenic rate, birth rate, or transgenic efficiency.
  • Founders with complete BAC integrations were observed in all 47 BACs for which multiple markers were tested.
  • Additional founders with BAC fragment integrations were observed for 65% of these BACs.
  • Expression data was available for 79 BAC transgenes and expression was observed in transgenic founders from 63 BACs (80%).
  • Consistent and reproducible success in BAC transgenesis required the combination of careful DNA purification, the use of polyamine buffer, and sensitive genotyping assays.

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  • (PMID = 19396621.001).
  • [ISSN] 1573-9368
  • [Journal-full-title] Transgenic research
  • [ISO-abbreviation] Transgenic Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA046592; United States / NCI NIH HHS / CA / CA046592-14; United States / NIDDK NIH HHS / DK / DK034933; United States / NIDDK NIH HHS / DK / P30 DK034933; United States / NIAMS NIH HHS / AR / AR048310; United States / NCI NIH HHS / CA / P30 CA046592-14; United States / NIAMS NIH HHS / AR / P30 AR048310; United States / NIA NIH HHS / AG / P30 AG013283; United States / NCI NIH HHS / CA / CA046592; United States / NIA NIH HHS / AG / AG013283
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA, Bacterial
  • [Other-IDs] NLM/ NIHMS243268; NLM/ PMC3016422
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67. Dhingra A, Folta KM: ASAP: amplification, sequencing & annotation of plastomes. BMC Genomics; 2005;6:176
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  • Traditionally, the first step in mining the valuable information within a chloroplast genome requires sequencing a chloroplast plasmid library or BAC clones.
  • These activities involve complicated preparatory procedures like chloroplast DNA isolation or identification of the appropriate BAC clones to be sequenced.

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  • [ISSN] 1471-2164
  • [Journal-full-title] BMC genomics
  • [ISO-abbreviation] BMC Genomics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA Primers; 0 / DNA, Chloroplast; 0 / DNA, Plant
  • [Other-IDs] NLM/ PMC1318494
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68. Tjia WM, Hu L, Zhang MY, Guan XY: Characterization of rearrangements involving 4q, 13q and 16q in hepatocellular carcinoma cell lines using region-specific multiplex-FISH probes. Cancer Lett; 2007 May 18;250(1):92-9
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  • [Title] Characterization of rearrangements involving 4q, 13q and 16q in hepatocellular carcinoma cell lines using region-specific multiplex-FISH probes.
  • Deletions in 4q, 13q and 16q were frequently detected in hepatocellular carcinoma (HCC) by comparative genomic hybridization (CGH) studies.
  • Using CGH combined with multiplex-color FISH (M-FISH) with chromosome region-specific probes (CRPs), chromosome structural aberrations in 4q, 13q and 16q in six HCC cell lines were studied.
  • FISH with BAC probes was used to further characterize translocation breakpoints and deletions.
  • A breakpoint at 16q22 was localized at a BAC clone (RP11-341K23) and another breakpoint at 4q28 was localized within a 620 kb-region.
  • A minimal deleted region at 13q21 was found between BAC clones RP11-240M20 and RP11-435P18.
  • This study demonstrated that the combination of CGH, M-FISH and BAC-FISH is a very useful tool to detect and characterize translocation breakpoint.
  • [MeSH-major] Carcinoma, Hepatocellular / genetics. Chromosome Aberrations. Chromosomes, Human, Pair 13. Chromosomes, Human, Pair 16. Chromosomes, Human, Pair 4. In Situ Hybridization, Fluorescence / methods. Liver Neoplasms / genetics
  • [MeSH-minor] Cell Line, Tumor. Humans. Translocation, Genetic

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  • (PMID = 17098359.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
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69. Guo W, Cai C, Wang C, Zhao L, Wang L, Zhang T: A preliminary analysis of genome structure and composition in Gossypium hirsutum. BMC Genomics; 2008;9:314
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  • Here, we employed GeneTrek and BAC tagging information approaches to predict the general composition and structure of the allotetraploid cotton genome.
  • RESULTS: 142 BAC sequences from Gossypium hirsutum cv.
  • These BAC sequence analysis revealed that the tetraploid cotton genome contains over 70,000 candidate genes with duplicated gene copies in homoeologous A- and D-subgenome regions.
  • Twenty-one percent of the 142 BACs lacked genes.
  • BAC gene density ranged from 0 to 33.2 per 100 kb, whereas most gene islands contained only one gene with an average of 1.5 genes per island.
  • In addition, 166 polymorphic loci amplified with SSRs developed from 70 BAC clones were tagged on our backbone genetic map.
  • Hai7124, and diploid G. herbaceum var. africanum and G. raimondii, 37 BACs, 12 from the A- and 25 from the D-subgenome, were further anchored to their corresponding subgenome chromosomes.
  • After a large amount of genes sequence comparison from different subgenome BACs, the result showed that introns might have no contribution to different subgenome size in Gossypium.
  • [MeSH-major] Chromosomes, Artificial, Bacterial. Genome, Plant. Gossypium / genetics. Polyploidy. Sequence Analysis, DNA

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  • (PMID = 18590573.001).
  • [ISSN] 1471-2164
  • [Journal-full-title] BMC genomics
  • [ISO-abbreviation] BMC Genomics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Genetic Markers; 0 / Retroelements
  • [Other-IDs] NLM/ PMC2481271
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70. Vorstman JA, Jalali GR, Rappaport EF, Hacker AM, Scott C, Emanuel BS: MLPA: a rapid, reliable, and sensitive method for detection and analysis of abnormalities of 22q. Hum Mutat; 2006 Aug;27(8):814-21
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  • All samples in the training set have been previously characterized by fluorescence in situ hybridization (FISH) with cosmid or BAC clones and/or cytogenetic studies.
  • Given that MLPA is likely to be used as an initial screening method, a higher sensitivity, at the cost of a lower specificity, was deemed more appropriate.

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  • (PMID = 16791841.001).
  • [ISSN] 1098-1004
  • [Journal-full-title] Human mutation
  • [ISO-abbreviation] Hum. Mutat.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA 39926; United States / NICHD NIH HHS / HD / HD26979; United States / NICHD NIH HHS / HD / P30 HD026979; United States / NCI NIH HHS / CA / R01 CA039926-18; United States / NCI NIH HHS / CA / CA039926-18; United States / NIDCD NIH HHS / DC / DC02027; United States / NCI NIH HHS / CA / R01 CA039926; United States / NIDCD NIH HHS / DC / P01 DC002027
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS160121; NLM/ PMC2814414
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71. Kim YT, Kim TY, Lee DS, Park SJ, Park JY, Seo SJ, Choi HS, Kang HJ, Hahn S, Kang CH, Sung SW, Kim JH: Molecular changes of epidermal growth factor receptor (EGFR) and KRAS and their impact on the clinical outcomes in surgically resected adenocarcinoma of the lung. Lung Cancer; 2008 Jan;59(1):111-8
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  • [Title] Molecular changes of epidermal growth factor receptor (EGFR) and KRAS and their impact on the clinical outcomes in surgically resected adenocarcinoma of the lung.
  • Recent studies have reported that clinical response to epidermal growth factor receptor (EGFR) inhibitors is associated with somatic changes of EGFR in the advanced stage of lung cancer.
  • However, there is no clear data demonstrating whether such molecular changes of EGFR per se can affect the clinical outcome of early stage cancer after surgical resection.
  • DNA mutations of EGFR and KRAS were investigated in 71 adenocarcinoma patients who received surgical resection.
  • EGFR mutation was more frequently found in cases with BAC features (13/22 (59.1%):13/49 (26.5%); p=0.008) and in non-smokers (19/41 (46.3%):7/30 (23.3%); p=0.047).
  • KRAS mutations (p=0.000), male gender (p=0.001), absence of BAC feature (p=0.003), advanced stage (p=0.039), and smoking history (p=0.030) were poor prognostic factors for overall survival, whereas EGFR mutation (p=0.184) and amplification (p=0.756) were not.
  • The presence of EGFR mutation was not a prognostic factor of the clinical outcome of early lung cancer after surgical resection.
  • This result provides an important message for the protocol design of future trials of EGFR inhibitors in early lung cancer.
  • DNA mutations of EGFR and KRAS were investigated in 71 adenocarcinoma patients who received surgical resection.
  • Whereas KRAS mutation was a poor prognostic factor, EGFR mutation was not, and its presence per se did not affect the clinical outcome of early lung cancer after surgical resection.
  • [MeSH-major] Adenocarcinoma / genetics. Genes, ras. Lung Neoplasms / genetics. Mutation. Receptor, Epidermal Growth Factor / genetics

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  • (PMID = 17904685.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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72. Domi A, Moss B: Engineering of a vaccinia virus bacterial artificial chromosome in Escherichia coli by bacteriophage lambda-based recombination. Nat Methods; 2005 Feb;2(2):95-7
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  • [Title] Engineering of a vaccinia virus bacterial artificial chromosome in Escherichia coli by bacteriophage lambda-based recombination.
  • Here we describe how a bacterial artificial chromosome (BAC) containing the entire VAC genome can be engineered in Escherichia coli by homologous recombination using bacteriophage lambda-encoded enzymes.
  • [MeSH-major] Bacteriophage lambda / genetics. Chromosomes, Artificial, Bacterial / genetics. Escherichia coli / genetics. Escherichia coli / virology. Genetic Engineering / methods. Transfection / methods. Vaccinia / genetics
  • [MeSH-minor] Cloning, Molecular / methods. Genome, Bacterial. Genome, Viral. Recombination, Genetic / genetics. Transformation, Bacterial / genetics

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  • (PMID = 15782205.001).
  • [ISSN] 1548-7091
  • [Journal-full-title] Nature methods
  • [ISO-abbreviation] Nat. Methods
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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73. Serikawa T, Mashimo T, Takizawa A, Okajima R, Maedomari N, Kumafuji K, Tagami F, Neoda Y, Otsuki M, Nakanishi S, Yamasaki K, Voigt B, Kuramoto T: National BioResource Project-Rat and related activities. Exp Anim; 2009 Jul;58(4):333-41
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  • This review article introduces NBRP-Rat and highlights the phenome project, recombinant inbred strains, BAC clone libraries, and the ENU-mutant archive, named the Kyoto University Rat Mutant Archive (KURMA).

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  • (PMID = 19654430.001).
  • [ISSN] 1881-7122
  • [Journal-full-title] Experimental animals
  • [ISO-abbreviation] Exp. Anim.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Japan
  • [Number-of-references] 29
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74. Pérez López ME, García Mata J, García Gómez J, Salgado Fernández M, Fírvida Pérez JL: [Prostate adenocarcinoma and synchcronous multiple myeloma: a case report]. Actas Urol Esp; 2007 Feb;31(2):157-9
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  • [Title] [Prostate adenocarcinoma and synchcronous multiple myeloma: a case report].
  • [Transliterated title] Adenocarcinoma prostático y mieloma múltiple sincrónicos: a propósito de un caso.
  • PURPOSE: To report a case of synchronous prostatic cancer with multiple myeloma as inusual neoplasm presentation.
  • To indicate the clinical data that they help to suspect the myeloma presence in the prostate bone metastatic disease.
  • CASE REPORT: Patient 63 years old diagnosed of prostatic carcinoma with bone metastasis and BAC good responsive, who have clinical deterioration, hypercalcemia and renal insufficiency.
  • [MeSH-major] Adenocarcinoma / diagnosis. Multiple Myeloma / diagnosis. Neoplasms, Multiple Primary / diagnosis. Prostatic Neoplasms / diagnosis

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  • (PMID = 17645096.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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75. Fan ZC, Bird RC: Generation and characterization of an Npro-disrupted marker bovine viral diarrhea virus derived from a BAC cDNA. J Virol Methods; 2008 Aug;151(2):257-63
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  • [Title] Generation and characterization of an Npro-disrupted marker bovine viral diarrhea virus derived from a BAC cDNA.
  • In this study, an N(pro)-disrupted cDNA, pBSD1-N(pro)/eGFP2A, was constructed based on an infectious full-length BAC cDNA clone of NCP BVDV strain SD1, pBSD1.
  • In this clone, whole N(pro) gene except its first 57 nucleotides (nt) was in frame substituted with an eGFP2A sequence. eGFP2A was constructed by in frame fusing a foot-and-mouth disease virus 2A protease (FMDV 2A(pro)) to C-terminus of eGFP.
  • Intramolecular cleavage of FMDV 2A(pro) at its C-terminal glycine-proline dipeptide will release the viral nucleocapsid protein from the nascent viral polyprotein and the processed eGFP2A protein will then act as a marker protein.
  • The resulting BAC cDNA clone was propagated stably for at least 10 passages in E. coli strain XL1-blue as determined by sequencing the progeny plasmids.
  • [MeSH-minor] Animals. Bovine Virus Diarrhea-Mucosal Disease / epidemiology. Cattle. Cell Line. DNA Primers. DNA, Complementary. Genes, Reporter. Genetic Markers. Immunoblotting. Kidney. United States / epidemiology

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  • (PMID = 18555541.001).
  • [ISSN] 0166-0934
  • [Journal-full-title] Journal of virological methods
  • [ISO-abbreviation] J. Virol. Methods
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA Primers; 0 / DNA, Complementary; 0 / DNA, Viral; 0 / Genetic Markers; 0 / Npro protein, bovine viral diarrhea virus; 0 / Viral Proteins
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76. Devaux B, Rosenstingl S, Bardet M, Coldea L, Gatfosse M: [Abnormalities of hand skin]. Rev Med Interne; 2009 May;30(5):434-5
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  • [Transliterated title] Des anomalies de la peau des mains.

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  • (PMID = 19264380.001).
  • [ISSN] 0248-8663
  • [Journal-full-title] La Revue de medecine interne
  • [ISO-abbreviation] Rev Med Interne
  • [Language] FRE
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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77. Pelosi G, Rosai J: Invited commentary. Ann Thorac Surg; 2007 Jan;83(1):214-5
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  • [MeSH-major] Adenocarcinoma / classification. Adenocarcinoma, Bronchiolo-Alveolar / classification. Lung Neoplasms / classification

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  • [CommentOn] Ann Thorac Surg. 2007 Jan;83(1):209-14 [17184664.001]
  • (PMID = 17184665.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Comment; Journal Article
  • [Publication-country] Netherlands
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78. Ulmeanu R, Mihăltan F, Crişan E, Alexe M, Grigore P, Andreescu I, Galbenu P, Leonte D: [Practical issues of transbronchial lung biopsy (TLB) in pneumology]. Pneumologia; 2007 Apr-Jun;56(2):59-67
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  • [Title] [Practical issues of transbronchial lung biopsy (TLB) in pneumology].
  • METHOD: We present a survey of 78 TLB which have been performed in Bronchology Service (during 2003-2005) for diffuse interstitial lung diseases--70 cases or located diseases--8 cases; TLB was not performed for solitary peripherally opacities because we have no radiological device with mobile arm (for good position of forceps).
  • RESULTS: In 78% of cases we obtained illustrative lung tissue and in 22% of cases we prelevated just bronchial wall.
  • Histological confirmation was obtained for 53% of cases; 47% of cases have as result lung tissue without significant modifications.
  • Histological diagnosis was obtain in 41% of cases.
  • The diagnosis of lung pathology was: diffuse lung fibrosis, tuberculosis, sarcoidosis stage II-III, malignant lymphoma, carcinomatosis, undifferentiated carcinoma, bronchioloalveolar carcinoma, squamous carcinoma, adenocarcinoma.
  • The international guidelines request that the TLB has to be made before the thoracoscopy or the thoracotomy; because of the small size of prelevated fragments the diagnosis sensibility is variable.
  • Our results for the 78 cases are comparable with the international data from literature both from the point of view of the diagnosis and the complications.
  • [MeSH-major] Biopsy, Needle / methods. Bronchoscopy. Lung Diseases / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma, Bronchiolo-Alveolar / pathology. Aged. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Female. Granulomatosis with Polyangiitis / pathology. Health Surveys. Humans. Lung Neoplasms / pathology. Lymphoma, Non-Hodgkin / pathology. Male. Middle Aged. Practice Guidelines as Topic. Pulmonary Fibrosis / pathology. Sarcoidosis, Pulmonary / pathology. Sensitivity and Specificity. Tuberculosis, Pulmonary / pathology

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  • (PMID = 18019749.001).
  • [ISSN] 2067-2993
  • [Journal-full-title] Pneumologia (Bucharest, Romania)
  • [ISO-abbreviation] Pneumologia
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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79. Oldenburg RA, Kroeze-Jansema KH, Houwing-Duistermaat JJ, Bayley JP, Dambrot C, van Asperen CJ, van den Ouweland AM, Bakker B, van Beers EH, Nederlof PM, Vasen H, Hoogerbrugge N, Cornelisse CJ, Meijers-Heijboer H, Devilee P: Genome-wide linkage scan in Dutch hereditary non-BRCA1/2 breast cancer families identifies 9q21-22 as a putative breast cancer susceptibility locus. Genes Chromosomes Cancer; 2008 Nov;47(11):947-56
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  • [Title] Genome-wide linkage scan in Dutch hereditary non-BRCA1/2 breast cancer families identifies 9q21-22 as a putative breast cancer susceptibility locus.
  • Breast cancer accounts for over 20% of all female cancers.
  • A positive family history remains one of the most important risk factors for the disease, with first-degree relatives of patients having a twofold elevated risk.
  • Known breast cancer susceptibility genes such as BRCA1 and BRCA2 explain only 20-25% of this risk, suggesting the existence of other breast cancer susceptibility genes.
  • Here, we report the results of a genome-wide linkage scan in 55 high-risk Dutch breast cancer families with no mutations in BRCA1 and BRCA2.
  • Twenty-two of these families were also part of a previous linkage study by the Breast Cancer Linkage Consortium.
  • With CGH analyses we observed preferential copy number loss at BAC RP11-276H19, containing D9S167 in familial tumors as compared to sporadic tumors (P < 0.001).
  • [MeSH-major] Breast Neoplasms / genetics. Chromosomes, Human, Pair 9 / genetics. Genetic Linkage. Genetic Predisposition to Disease. Genome, Human


80. Qiu SQ, Liu K, Jiang JX, Song X, Xu CG, Li XH, Zhang Q: Delimitation of the rice wide compatibility gene S5 ( n ) to a 40-kb DNA fragment. Theor Appl Genet; 2005 Oct;111(6):1080-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A physical map consisting of six overlapping BAC clones was formed, spanning a genomic region of 540-kb in length.
  • [MeSH-minor] Aspartic Acid Endopeptidases / genetics. Chromosomes, Artificial, Bacterial. Crosses, Genetic. Fertility / genetics. Fucosyltransferases / genetics. Heat-Shock Proteins / genetics. Molecular Chaperones / genetics. Polymorphism, Restriction Fragment Length. Sequence Analysis, DNA

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  • (PMID = 16177904.001).
  • [ISSN] 0040-5752
  • [Journal-full-title] TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik
  • [ISO-abbreviation] Theor. Appl. Genet.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Heat-Shock Proteins; 0 / Molecular Chaperones; 0 / molecular chaperone GRP78; EC 2.4.1.- / Fucosyltransferases; EC 2.4.1.- / xyloglucan 2-fucosyltransferase; EC 3.4.23.- / Aspartic Acid Endopeptidases
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81. Rajamohan F, Harris MS, Frisbie RK, Hoth LR, Geoghegan KF, Valentine JJ, Reyes AR, Landro JA, Qiu X, Kurumbail RG: Escherichia coli expression, purification and characterization of functional full-length recombinant alpha2beta2gamma3 heterotrimeric complex of human AMP-activated protein kinase. Protein Expr Purif; 2010 Oct;73(2):189-97
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  • [Title] Escherichia coli expression, purification and characterization of functional full-length recombinant alpha2beta2gamma3 heterotrimeric complex of human AMP-activated protein kinase.
  • The muscle-specific AMPK heterotrimeric complex (alpha2beta2gamma3) is involved in glucose and fat metabolism in skeletal muscle and therefore has emerged as an attractive target for drug development for diabetes and metabolic syndrome.
  • Here we describe the expression, purification and biochemical characterization of functional full-length AMPK alpha2beta2gamma3 heterotrimeric complex using an Escherichia coli expression system.
  • All three subunits of AMPK alpha2beta2gamma3 were transcribed as a single tricistronic transcript driven by the T7 RNA polymerase promoter, allowing spontaneous formation of the heterotrimeric complex in the bacterial cytosol.
  • The self-assembled trimeric complex was purified from the cell lysate by nickel-ion chromatography using the hexahistidine tag fused exclusively at the N-terminus of the alpha 2 domain.
  • The final yield of the recombinant AMPK alpha2beta2gamma3 complex was 1.1mg/L culture in shaker flasks.
  • The kinase activity of activated AMPK alpha2beta2gamma3 complex was significantly enhanced by AMP (an allosteric activator) but not by thienopyridone A-769662, a known small molecule activator of AMPK.
  • Mass spectrometric characterization of recombinant AMPK alpha2beta2gamma3 showed significant heterogeneity before and after activation that could potentially hamper crystallographic studies of this complex.

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20451617.001).
  • [ISSN] 1096-0279
  • [Journal-full-title] Protein expression and purification
  • [ISO-abbreviation] Protein Expr. Purif.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / A 769662; 0 / Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit; 0 / Protein Subunits; 0 / Pyrones; 0 / Recombinant Proteins; 0 / Thiophenes; 415SHH325A / Adenosine Monophosphate; EC 2.7.11.1 / AMP-Activated Protein Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.17 / Calcium-Calmodulin-Dependent Protein Kinase Kinase
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82. Khandani AH, Whitney KD, Keller SM, Isasi CR, Donald Blaufox M: Sensitivity of FDG PET, GLUT1 expression and proliferative index in bronchioloalveolar lung cancer. Nucl Med Commun; 2007 Mar;28(3):173-7
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  • [Title] Sensitivity of FDG PET, GLUT1 expression and proliferative index in bronchioloalveolar lung cancer.
  • OBJECTIVE: To estimate the sensitivity of [F] fluorodeoxyglucose (FDG) positron emission tomography (PET) and to assess the expression of glucose transporter 1 (GLUT1) and proliferative index (PI) in bronchioloalveolar lung cancer (BAC).
  • METHODS: Twenty-four patients with resected BAC underwent preoperative PET between October 1996 and February 2003.
  • The surgical specimens were re-examined, and 18 patients who fulfilled the 1999 WHO definition for BAC were included in the study.
  • The pathology slides were stained with antibodies to GLUT1 and Proliferating cell nuclear antigen (PCNA) in order to determine GLUT1 expression and PI, respectively.
  • RESULTS: There were 13 cases of PET+ BAC (sensitivity, 72%; confidence interval, 52-93%); seven of them were GLUT1+ cases and six were GLUT1-.
  • The stromal cell PI was significantly higher in GLUT1+ BAC compared to GLUT- BAC (50.9+/-17.1 vs. 33.2+/-14.2, P=0.0286), and higher in PET+ BAC compared to PET- BAC (45.5+/-15.3 vs. 29.6+/-19.6, P=0.0854).
  • CONCLUSION: After applying the 1999 WHO criteria, the sensitivity of PET for detecting BAC is still relatively low.
  • Other glucose transporters such as GLUT3 likely play a role in FDG uptake in BAC.
  • GLUT1+ or PET+ BAC tumours have a higher stromal cell PI when compared to GLUT1- BAC or PET- BAC tumours, respectively.
  • [MeSH-major] Bronchial Neoplasms / diagnosis. Glucose Transporter Type 1 / biosynthesis. Lung Neoplasms / diagnosis
  • [MeSH-minor] Cell Proliferation. Cesium. Epithelial Cells / pathology. Fluorodeoxyglucose F18. Humans. Lung / pathology. Positron-Emission Tomography. Proliferating Cell Nuclear Antigen / biosynthesis. Proliferating Cell Nuclear Antigen / genetics. Radiopharmaceuticals. Stromal Cells / pathology. Tomography, X-Ray Computed


83. Yang Y, Gozen O, Vidensky S, Robinson MB, Rothstein JD: Epigenetic regulation of neuron-dependent induction of astroglial synaptic protein GLT1. Glia; 2010 Feb;58(3):277-86
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  • In this study, we established a procedure to selectively isolate a pure astrocyte population in vitro and in vivo from BAC GLT1 eGFP mice using an eGFP-based fluorescence-activated cell sorting approach.

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
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  • (PMID = 19672971.001).
  • [ISSN] 1098-1136
  • [Journal-full-title] Glia
  • [ISO-abbreviation] Glia
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / R01 NS036465; United States / NINDS NIH HHS / NS / R01 NS052179; United States / NINDS NIH HHS / NS / NS33958; United States / NINDS NIH HHS / NS / NS036465; United States / NINDS NIH HHS / NS / NS052179-05; United States / NINDS NIH HHS / NS / R01 NS033958-09; United States / NINDS NIH HHS / NS / R01 NS033958; United States / NINDS NIH HHS / NS / R01 NS052179-05; United States / NINDS NIH HHS / NS / NS033958-09
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Excitatory Amino Acid Transporter 2; 0 / Neurotoxins; 0 / Repressor Proteins; 3KX376GY7L / Glutamic Acid
  • [Other-IDs] NLM/ NIHMS136480; NLM/ PMC2794958
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84. Bonnet C, Grégoire MJ, Vibert M, Raffo E, Leheup B, Jonveaux P: Cryptic 7q21 and 9p23 deletions in a patient with apparently balanced de novo reciprocal translocation t(7;9)(q21;p23) associated with a dystonia-plus syndrome: paternal deletion of the epsilon-sarcoglycan (SGCE) gene. J Hum Genet; 2008;53(10):876-85
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  • [Title] Cryptic 7q21 and 9p23 deletions in a patient with apparently balanced de novo reciprocal translocation t(7;9)(q21;p23) associated with a dystonia-plus syndrome: paternal deletion of the epsilon-sarcoglycan (SGCE) gene.
  • Genetic investigations allowed the identification of an apparently balanced de novo reciprocal translocation, t(7;9)(q21;p23).
  • Breakpoint-region mapping using fluorescent in situ hybridization (FISH) analysis of bacterial artificial chromosome (BAC) clone probes identified microdeletions of 3.7 and 5.2 Mb within 7q21 and 9p23 breakpoint regions, respectively.
  • These results emphasize that the phenotypic abnormalities of apparently balanced de novo translocations can be due to cryptic deletions and that the precise mapping of these aneusomies may improve clinical management.

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  • (PMID = 18651096.001).
  • [ISSN] 1434-5161
  • [Journal-full-title] Journal of human genetics
  • [ISO-abbreviation] J. Hum. Genet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / SGCE protein, human; 0 / Sarcoglycans
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85. Rossi MR, Laduca J, Cowell JK, Srivastava BI, Matsui S: Genomic analysis of CD8+ NK/T cell line, 'SRIK-NKL', with array-based CGH (aCGH), SKY/FISH and molecular mapping. Leuk Res; 2008 Mar;32(3):455-63
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  • [Title] Genomic analysis of CD8+ NK/T cell line, 'SRIK-NKL', with array-based CGH (aCGH), SKY/FISH and molecular mapping.
  • We performed aCGH, SKY/FISH, molecular mapping and expression analyses on a permanent CD8+ NK/T cell line, 'SRIK-NKL' established from a lymphoma (ALL) patient, in attempt to define the fundamental genetic profile of its unique NK phenotypes. aCGH revealed hemizygous deletion of 6p containing genes responsible for hematopoietic functions.
  • The FISH analysis using a BAC which contains TRA@ and its flanking region further revealed a approximately 231kb deletion within 14q11 in the der(5) but not in the normal homologue of no. 14.
  • The RT-PCR analysis detected mRNA for TRA@ transcripts which were extending across, but not including, the deleted region.
  • In addition to rcpt(5;14), aCGH identified novel copy number abnormalities suggesting that the unique phenotype of the SRIK-NKL cell line is not solely due to the TRA@ rearrangement.

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  • (PMID = 17640729.001).
  • [ISSN] 0145-2126
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA016056-31; United States / NCI NIH HHS / CA / P30 CA016056; United States / NCI NIH HHS / CA / CA 16056; United States / NCI NIH HHS / CA / P30 CA016056-31
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD8
  • [Other-IDs] NLM/ NIHMS42920; NLM/ PMC2855542
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86. Komura D, Shen F, Ishikawa S, Fitch KR, Chen W, Zhang J, Liu G, Ihara S, Nakamura H, Hurles ME, Lee C, Scherer SW, Jones KW, Shapero MH, Huang J, Aburatani H: Genome-wide detection of human copy number variations using high-density DNA oligonucleotide arrays. Genome Res; 2006 Dec;16(12):1575-84
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  • In addition, the contribution of CNVs to human disease susceptibility may be greater than previously expected, although a complete understanding of the phenotypic consequences of CNVs is incomplete.
  • We have recently reported a comprehensive view of CNVs among 270 HapMap samples using high-density SNP genotyping arrays and BAC array CGH.
  • Independent testing of a subset of CNVs by quantitative PCR and mass spectrometry demonstrated a >90% verification rate.

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  • (PMID = 17122084.001).
  • [ISSN] 1088-9051
  • [Journal-full-title] Genome research
  • [ISO-abbreviation] Genome Res.
  • [Language] eng
  • [Databank-accession-numbers] GEO/ GSE5013/ GSE5173
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-49-2 / DNA
  • [Other-IDs] NLM/ PMC1665641
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87. Szamalek JM, Goidts V, Chuzhanova N, Hameister H, Cooper DN, Kehrer-Sawatzki H: Molecular characterisation of the pericentric inversion that distinguishes human chromosome 5 from the homologous chimpanzee chromosome. Hum Genet; 2005 Jul;117(2-3):168-76
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  • Breakpoint-spanning BAC clones were identified from both the human and chimpanzee genomes by fluorescence in situ hybridisation, and the precise locations of the breakpoints were determined by sequence comparisons.
  • [MeSH-minor] Animals. Cell Line, Tumor. Humans. Karyotyping

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  • (PMID = 15883840.001).
  • [ISSN] 0340-6717
  • [Journal-full-title] Human genetics
  • [ISO-abbreviation] Hum. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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88. Li L, Zhu W, Zhang P, Zhang Q, Zhang Z: AC/O3-BAC processes for removing refractory and hazardous pollutants in raw water. J Hazard Mater; 2006 Jul 31;135(1-3):129-33
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  • [Title] AC/O3-BAC processes for removing refractory and hazardous pollutants in raw water.
  • Granular activated carbon (AC)/O(3)-biological activated carbon (BAC) process was employed to treat raw water and compared to O(3)-BAC process in its optimum parameters (3 mg/L ozone dosage with 15 min oxidation time and 15 min empty bed contact time in BAC).
  • For dissolved organic carbon (DOC) removal, AC/O(3)-BAC was more efficient than O(3)-BAC and its synergetic effect could be noticed.
  • GC/MS analysis showed that AC/O(3)-BAC process was effective in removing phthalate esters (PAEs) and persistent organic pollutants (POPs).

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  • (PMID = 16386361.001).
  • [ISSN] 0304-3894
  • [Journal-full-title] Journal of hazardous materials
  • [ISO-abbreviation] J. Hazard. Mater.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Water Pollutants, Chemical; 66H7ZZK23N / Ozone; 7440-44-0 / Carbon
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89. Chaves LD, Harry DE, Reed KM: Genome-wide genetic diversity of 'Nici', the DNA source for the CHORI-260 turkey BAC library and candidate for whole genome sequencing. Anim Genet; 2009 Jun;40(3):348-52
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  • [Title] Genome-wide genetic diversity of 'Nici', the DNA source for the CHORI-260 turkey BAC library and candidate for whole genome sequencing.
  • Here we examined the source DNA [Nicholas inbred (Nici)] of the CHORI-260 turkey bacterial artificial chromosome (BAC) library through analysis of microsatellites and BAC sequences.
  • [MeSH-major] Chromosomes, Artificial, Bacterial / genetics. DNA / genetics. Turkeys / genetics

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  • (PMID = 19292710.001).
  • [ISSN] 1365-2052
  • [Journal-full-title] Animal genetics
  • [ISO-abbreviation] Anim. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 9007-49-2 / DNA
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90. Ng HY, Lee LY, Ong SL, Tao G, Viawanath B, Kekre K, Lay W, Seah H: Treatment of RO brine-towards sustainable water reclamation practice. Water Sci Technol; 2008;58(4):931-6
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  • The proposed treatment consists of biological activated carbon (BAC) column followed by capacitive deionization (CDI) process for organic and inorganic removals, respectively.
  • Preliminary bench-scale study demonstrated about 20% TOC removal efficiency was achieved using BAC at 40 mins empty bed contact time (EBCT) while the CDI process was able to remove more than 90% conductivity reducing it from 2.19 mS/cm to only about 164 microS/cm.
  • More than 90% cations and anions in the BAC effluent were removed using CDI process.

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  • [Copyright] Copyright IWA Publishing 2008.
  • (PMID = 18776632.001).
  • [ISSN] 0273-1223
  • [Journal-full-title] Water science and technology : a journal of the International Association on Water Pollution Research
  • [ISO-abbreviation] Water Sci. Technol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Inorganic Chemicals; 0 / Organic Chemicals; 0 / Water Pollutants, Chemical; 7440-44-0 / Carbon
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91. Lux R, Shi W: A novel bacterial signalling system with a combination of a Ser/Thr kinase cascade and a His/Asp two-component system. Mol Microbiol; 2005 Oct;58(2):345-8
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  • [Title] A novel bacterial signalling system with a combination of a Ser/Thr kinase cascade and a His/Asp two-component system.
  • Prokaryotes and eukaryotes have long been thought to use very different types of kinases (the His kinases of the 'bacterial' two-component systems versus the 'eukaryotic' Ser/Thr/Tyr kinases) to carry out signal transduction.
  • Pioneering work on bacterial protein serine threonine kinases (PSTKs) has been performed in Myxococcus xanthus, a soil bacterium with a complex life cycle that possesses orthologues of signalling-related kinases 'typical' of both the prokaryotic and the eukaryotic kingdoms.
  • In the work reported in this volume of Molecular Microbiology, Nariya and Inouye describe a PSTK cascade that modulates the biochemical activity of MrpC, a CRP-like transcriptional regulator for essential developmental signalling pathways in M. xanthus whose transcription is under the control of a two-component system.
  • This is the first report of both a functional PSTK cascade in bacteria and the use of both PSTK and two-component systems to control a single complex bacterial signalling event.
  • [MeSH-minor] Bacterial Proteins / genetics. Bacterial Proteins / metabolism. Gene Expression Regulation, Bacterial. Transcription Factors / genetics. Transcription Factors / metabolism

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  • [CommentOn] Mol Microbiol. 2005 Oct;58(2):367-79 [16194226.001]
  • (PMID = 16194223.001).
  • [ISSN] 0950-382X
  • [Journal-full-title] Molecular microbiology
  • [ISO-abbreviation] Mol. Microbiol.
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / GM54666
  • [Publication-type] Comment; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / MrpC protein, Myxococcus xanthus; 0 / Transcription Factors; EC 2.7.- / Protein Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.2.4 / Aspartate Kinase; EC 2.7.3.- / protein-histidine kinase
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92. Zhu ZY, Wang CM, Feng F, Yue GH: Isolation and characterization of 51 microsatellites from BAC clones in Asian seabass, Lates calcarifer. Anim Genet; 2009 Feb;40(1):125-6
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  • [Title] Isolation and characterization of 51 microsatellites from BAC clones in Asian seabass, Lates calcarifer.
  • [MeSH-minor] Animals. Chromosomes, Artificial, Bacterial

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  • (PMID = 18945291.001).
  • [ISSN] 1365-2052
  • [Journal-full-title] Animal genetics
  • [ISO-abbreviation] Anim. Genet.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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93. Aida S, Ohara I, Shimazaki H, Dai Y, Ogata S, Ozeki Y, Tamai S: Solitary peripheral ciliated glandular papillomas of the lung: a report of 3 cases. Am J Surg Pathol; 2008 Oct;32(10):1489-94
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  • [Title] Solitary peripheral ciliated glandular papillomas of the lung: a report of 3 cases.
  • We report 3 cases of solitary papillomas located in peripheral regions of the lung that are extremely rare in the literature.
  • The neoplastic epithelium extended to the alveolar region and showed a similar appearance to bronchioloalveolar or papillary type adenocarcinomas.
  • For differential diagnosis, it is noteworthy that endobronchiolar papillomatous fronds constantly exist and spreading along alveolar walls is limited in adjacent alveoli in peripheral papillomas.
  • The presence of ciliated cells and basal cells is considered an important finding to suggest benign character of the lesion.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / pathology. Bronchial Neoplasms / pathology. Lung Neoplasms / pathology. Neoplasms, Glandular and Epithelial / pathology. Papilloma / pathology. Solitary Pulmonary Nodule / pathology
  • [MeSH-minor] Aged. Bronchi / pathology. Cilia / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged. Pulmonary Alveoli / pathology. Respiratory Mucosa / pathology

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  • (PMID = 18708941.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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94. Mormino EC, Kluth JT, Madison CM, Rabinovici GD, Baker SL, Miller BL, Koeppe RA, Mathis CA, Weiner MW, Jagust WJ, Alzheimer's Disease Neuroimaging Initiative: Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects. Brain; 2009 May;132(Pt 5):1310-23
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  • Although beta-amyloid (Abeta) plaques are a primary diagnostic criterion for Alzheimer's disease, this pathology is commonly observed in the brains of non-demented older individuals.
  • To explore the importance of this pathology in the absence of dementia, we compared levels of amyloid deposition (via 'Pittsburgh Compound-B' (PIB) positron emission tomography (PET) imaging) to hippocampus volume (HV) and episodic memory (EM) in three groups: (i) normal controls (NC) from the Berkeley Aging Cohort (BAC NC, n = 20);.
  • (ii) normal controls (NC) from the Alzheimer's disease neuroimaging initiative (ADNI NC, n = 17); and (iii) PIB+ mild cognitive impairment subjects from the ADNI (ADNI PIB+ MCI, n = 39).
  • In BAC NC, elevated PIB uptake was significantly associated with smaller aHV (P = 0.0016) and worse EM (P = 0.0086).
  • [MeSH-minor] Age Factors. Aged. Aging / physiology. Alzheimer Disease / diagnostic imaging. Alzheimer Disease / pathology. Alzheimer Disease / psychology. Aniline Compounds. Atrophy. Carbon Radioisotopes. Case-Control Studies. Educational Status. Female. Humans. Linear Models. Magnetic Resonance Imaging. Male. Middle Aged. Multivariate Analysis. Organ Size. Positron-Emission Tomography / methods. Psychiatric Status Rating Scales. Radiopharmaceuticals. Sex Factors. Thiazoles

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  • (PMID = 19042931.001).
  • [ISSN] 1460-2156
  • [Journal-full-title] Brain : a journal of neurology
  • [ISO-abbreviation] Brain
  • [Language] eng
  • [Grant] United States / NIA NIH HHS / AG / R01 AG034570; United States / NIA NIH HHS / AG / P50 AG023501; United States / NIA NIH HHS / AG / AG024904; United States / NIA NIH HHS / AG / R01 AG027342; United States / NIA NIH HHS / AG / U01 AG024904; United States / NIA NIH HHS / AG / U19 AG010483; United States / NIA NIH HHS / AG / R01 AG027859; United States / NIA NIH HHS / AG / K23 AG031861; United States / NIA NIH HHS / AG / AG027859; United Kingdom / Medical Research Council / / G0601846; United States / NIA NIH HHS / AG / P01 AG010491-14; United States / NIA NIH HHS / AG / P01 AG010491; United States / NIA NIH HHS / AG / P30 AG019610; United States / NIA NIH HHS / AG / R01 AG027859-02
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; 0 / Amyloid beta-Peptides; 0 / Aniline Compounds; 0 / Carbon Radioisotopes; 0 / Radiopharmaceuticals; 0 / Thiazoles
  • [Other-IDs] NLM/ PMC2677792
  • [Investigator] Weiner M; Thal L; Weiner M; Thal L; Petersen R; Jack CR Jr; Jagust W; Trojanowki J; Toga AW; Beckett L; Green RC; Gamst A; Potter WZ; Green RC; Montine T; Petersen R; Thal L; Jack CR Jr; Anders D; Bernstein M; Felmlee J; Fox N; Thompson P; Schuff N; Alexander G; Jagust W; Bandy D; Koeppe RA; Foster N; Reiman EM; Chen K; Trojanowki J; Shaw L; Lee VM; Korecka M; Toga AW; Crawford K; Neu S; Beckett L; Harvey D; Gamst A; Kornak J; Kachaturian Z; Frank R; Snyder PJ; Molchan S; Kaye J; Vorobik R; Quinn J; Schneider L; Pawluczyk S; Spann B; Fleisher AS; Vanderswag H; Heidebrink JL; Lord JL; Petersen R; Johnson K; Doody RS; Villanueva-Meyer J; Chowdhury M; Stern Y; Honig LS; Bell KL; Morris JC; Mintun MA; Schneider S; Marson D; Griffith R; Badger B; Grossman H; Tang C; Stern J; deToledo-Morrell L; Shah RC; Bach J; Duara R; Isaacson R; Strauman S; Albert MS; Pedroso J; Toroney J; Rusinek H; de Leon MJ; De Santi SM; Doraiswamy PM; Petrella JR; Aiello M; Clark CM; Pham C; Nunez J; Smith CD; Given CA 2nd; Hardy P; DeKosky ST; Oakley M; Simpson DM; Ismail MS; Porsteinsson A; McCallum C; Cramer SC; Mulnard RA; McAdams-Ortiz C; Diaz-Arrastia R; Martin-Cook K; DeVous M; Levey AI; Lah JJ; Cellar JS; Burns JM; Anderson HS; Laubinger MM; Bartzokis G; Silverman DH; Lu PH; Fletcher R; Parfitt F; Johnson H; Farlow M; Herring S; Hake AM; van Dyck CH; MacAvoy MG; Bifano LA; Chertkow H; Bergman H; Hosein C; Black S; Graham S; Caldwell C; Feldman H; Assaly M; Hsiung GY; Kertesz A; Rogers J; Trost D; Bernick C; Gitelman D; Johnson N; Mesulam M; Sadowsky C; Villena T; Mesner S; Aisen PS; Johnson KB; Behan KE; Sperling RA; Rentz DM; Johnson KA; Rosen A; Tinklenberg J; Ashford W; Sabbagh M; Connor D; Obradov S; Green RC; Killiany R; Norbash A; Obisesan TO; Jayam-Trouth A; Wang P; Auchus AP; Huang J; Friedland RP; DeCarli C; Fletcher E; Carmichael O; Kittur S; Mirje S; Johnson SC; Borrie M; Lee TY; Asthana S; Carlsson CM; Potkin SG; Highum D; Preda A; Nguyen D; Tariot PN; Reiman EM; Hendin BA; Scharre DW; Kataki M; Beversdorf DQ; Zimmerman EA; Celmins D; Brown AD; Gandy S; Marenberg ME; Rovner BW; Pearlson G; Blank K; Anderson K; Saykin AJ; Santulli RB; Pare N; Williamson JD; Sink KM; Potter H; Raj BA; Giordano A; Ott BR; Wu CK; Cohen R; Wilks KL; Safirstein BE
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95. Kim HB, Ahn S, Jang HJ, Sim SB, Kim KW: Evaluation of corrosion behaviors and surface profiles of platinum-coated electrodes by electrochemistry and complementary microscopy: biomedical implications for anticancer therapy. Micron; 2007;38(7):747-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Furthermore, nude mice inoculated with a bronchoalveolar cancer cell line and exposed to direct electric field showed the deterioration of proliferated tumor cells, proving the efficacy of electrochemical treatment.

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  • (PMID = 17493825.001).
  • [ISSN] 0968-4328
  • [Journal-full-title] Micron (Oxford, England : 1993)
  • [ISO-abbreviation] Micron
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 49DFR088MY / Platinum
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96. Inoue K, Wakakura M, Miyanaga Y, Tomita G: [Microbial contamination of nipradiol with and without benzalkonium chloride]. Nippon Ganka Gakkai Zasshi; 2010 Jul;114(7):604-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: To compare microbial contamination of nipradiol both with and without benzalkonium chloride (BAC).
  • SUBJECTS AND METHODS: Twenty primary open angle glaucoma patients treated with nipradiol with BAC were studied.
  • The nipradiol with BAC was switched to nipradiol without BAC.
  • Four weeks after switching, the nipradiol without BAC was once again switched to nipradiol with BAC.
  • RESULTS: In nipradiol without BAC microorganisms were isolated from caps (30%), nozzles (50%), solutions (0%), and filters (15%), whereas in nipradiol with BAC they were isolated from caps (35%), nozzles (40%), and solutions (25%).
  • The microorganisms in the nipradiol without BAC were coagulase-negative Staphylococci (38.2%) and Propionibacterium acnes (29.4%), and in the nipradiol with BAC they were coagulase-negative Staphylococci (20.5%), Alcaligenes xylosoxidans (12.8%).
  • CONCLUSIONS: In nipradiol without BAC, the bacteria were detected outside the filters, but not in the solution.
  • The rate of microbial contamination of the nipradiol without BAC was similar to that of the nipradiol with BAC.
  • Both the bacteria detected from the nipradiol with and those detected in the solution without BAC consisted only of bacterial flora of the cul-de-sac and skin.

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  • (PMID = 20681256.001).
  • [ISSN] 0029-0203
  • [Journal-full-title] Nippon Ganka Gakkai zasshi
  • [ISO-abbreviation] Nippon Ganka Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anti-Infective Agents, Local; 0 / Benzalkonium Compounds; 0 / Ophthalmic Solutions; 0 / Propanolamines; FVM336I71Y / nipradilol
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97. McCartt AT, Hellinga LA, Wells JK: Effects of a college community campaign on drinking and driving with a strong enforcement component. Traffic Inj Prev; 2009 Apr;10(2):141-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effects of a college community campaign on drinking and driving with a strong enforcement component.
  • The effects on driving at various blood alcohol concentrations (BACs) were evaluated, particularly for drivers ages 16-24 targeted by the program.
  • METHODS: Objective measures of driver BACs were collected through nighttime roadside surveys before and during the program in the experimental college community and a comparison college community.
  • Logistic regression models estimated the program's effects on the likelihood of driving at various BAC thresholds in the program community, after accounting for BAC patterns in the comparison community.
  • RESULTS: Relative to the comparison community, consistent reductions in driving at various BAC levels (positive BAC and BAC at least 0.02, 0.05, or 0.08%) were achieved in the experimental community.
  • Reductions were greatest for 16- to 20-year-olds (from 66% for positive BAC to 94% for BAC > or = 0.05%), followed by 21- to 24-year-olds (from 32% for positive BAC to 71% for BAC > or = 0.08%) and drivers 25 and older (from 23% for positive BAC to 53% for BAC > or = 0.08%).
  • All reductions for 16- to 20-year-olds were significant (p < 0.05), and all except the reduction for BAC > or = 0.08 percent were significantly greater than the corresponding reductions for drivers 25 and older.
  • Reductions for 21- to 24-year-olds were significant for BACs at least 0.02, 0.05, and 0.08 percent, but they were not significantly greater than the corresponding reductions for drivers 25 and older.

  • MedlinePlus Health Information. consumer health - Alcohol.
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  • (PMID = 19333826.001).
  • [ISSN] 1538-957X
  • [Journal-full-title] Traffic injury prevention
  • [ISO-abbreviation] Traffic Inj Prev
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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98.