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3. Shin JA, An M, Choi JI, Kim SH, Lee WJ, Park SJ, Park JW, Hong EK: [A case of hepatectomy for liver metastasis after pancreatoduodenectomy for carcinoma of ampulla of Vater]. Korean J Gastroenterol; 2006 Dec;48(6):434-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of hepatectomy for liver metastasis after pancreatoduodenectomy for carcinoma of ampulla of Vater].
  • Two major causes of the treatment failure are local recurrence and liver metastasis.
  • Liver metastases are often multiple and are associated with poor prognosis.
  • There have been few reports on long-term survivors after hepatectomy for metastatic liver tumors from carcinoma of ampulla of Vater.
  • Histologic examination of the resected specimen had revealed stage IB moderately-differentiated, intestinal type adenocarcinoma (T2N0M0).
  • Since neither local recurrence or distant metastasis were detected, the patient underwent liver segmentectomy.
  • Histologic study confirmed the presence of metastatic liver tumor from carcinoma of ampulla of Vater.
  • [MeSH-major] Ampulla of Vater. Carcinoma / diagnosis. Carcinoma / surgery. Common Bile Duct Neoplasms / pathology. Hepatectomy. Liver Neoplasms / diagnosis. Liver Neoplasms / surgery

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  • (PMID = 17189929.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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4. Chaudhary HB, Bhanot P, Logroño R: Phenotypic diversity of intrahepatic and extrahepatic cholangiocarcinoma on aspiration cytology and core needle biopsy: case series and review of the literature. Cancer; 2005 Aug 25;105(4):220-8
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  • BACKGROUND: Cholangiocarcinoma (CC) represents approximately 10% of primary liver malignancies and can mimic metastatic adenocarcinoma.
  • The phenotypic distribution of CC according to the World Health Organization (WHO) histologic classification was 9 adenocarcinoma (intrahepatic), not otherwise specified (NOS) (69%); 2 gastric foveolar type (extrahepatic) CCs (15%); 1 intestinal type (extrahepatic) CC (8%); and 1 sarcomatous/spindle cell type (intrahepatic) CC (8%).
  • One adenocarcinoma, NOS was well differentiated CC with bland tubular architecture, and one was pleomorphic.
  • The 1 sarcomatous/spindle cell type CC was chromogranin-negative and low molecular weight keratin (cell adhesion molecule 5.2)-positive, which excluded metastatic carcinoid.
  • Special types of CC with bland nuclear features posed a diagnostic challenge on cytologic evaluation, particularly the well differentiated CC with tubular architecture and the gastric foveolar type CC with mucin-producing tumor cells.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts, Extrahepatic / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / pathology. Liver Neoplasms / pathology

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  • [Copyright] Copyright (c) 2005 American Cancer Society.
  • (PMID = 15952192.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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5. Yoon YS, Kim SW, Jang JY, Park YH: Curative reoperation for recurrent cancer of the extrahepatic bile duct: report of two cases. Hepatogastroenterology; 2005 Mar-Apr;52(62):381-4
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  • [Title] Curative reoperation for recurrent cancer of the extrahepatic bile duct: report of two cases.
  • Local recurrence, following a resection for cancer of the extrahepatic bile duct, is usually incurable with second curative surgery being almost impossible.
  • The medical records and clinical outcomes of two patients that underwent a re-resection for recurrent cancer of the extrahepatic bile duct were retrospectively reviewed.
  • A 50-year-old female patient that had a recurrent disease at the intrahepatic and intrapancreatic bile duct, 66 months after a segmental resection of the bile duct for common bile duct (CBD) cancer, underwent a hepatopancreatoduodenectomy.
  • A 29-year-old female patient had a recurrent tumor mass in the distal CBD, 28 months after a right hemihepatectomy and Roux-en-Y hepaticojejenostomy for a type IIIa Klatskin tumor, and underwent a segmental resection of the bile duct.
  • The gross type of the above two cases was a papillary tumor.
  • It is concluded that a surgical re-resection is possible in selected patients with recurrent bile duct cancer, mostly of the papillary type.
  • A primary operation for bile duct cancer should be performed with a wide surgical margin, and secondary curative surgery should be considered whenever possible in cases of recurrence.
  • [MeSH-major] Adenocarcinoma, Papillary / surgery. Bile Duct Neoplasms / surgery. Bile Ducts, Extrahepatic. Klatskin Tumor / surgery
  • [MeSH-minor] Adult. Cholangiography. Female. Hepatectomy. Humans. Jejunostomy. Liver / surgery. Middle Aged. Neoplasm Recurrence, Local. Pancreaticoduodenectomy. Reoperation. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 15816441.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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6. Koswara T, Marwoto W, Siregar NC, Gumay S, Azis H, Abdullah M, Himawan S: Hepatoid carcinoma of the gallbladder. Acta Med Indones; 2007 Oct-Dec;39(4):179-82
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  • Hepatoid carcinoma is a special type of extrahepatic tumor associated with hepatic differentiation, and has the morphological and functional features of hepatocellular carcinoma.
  • The microscopic findings of the gallbladder after cholecystectomy showed an area of tumor with polygonal cells, eosinophilic cytoplasm, distinct cell borders, round vesicular nuclei and prominent nucleoli, arranged in trabecular pattern resembling hepatocellular carcinoma intermingled with areas of adenocarcinoma or cholangiocarcinoma.
  • The specimen from the pancreas also showed the same type of tumor cells.
  • The immunohistochemistry for alpha-fetoprotein (AFP) showed strong intra cytoplasmic positivity, both in tumor cells with hepatic differentiation and tumor cells with bile duct epithelium differentiation.
  • [MeSH-minor] Adenocarcinoma / secondary. Aged. Cholangiocarcinoma / secondary. Cholecystectomy. Fatal Outcome. Fatty Liver / pathology. Female. Humans. Immunohistochemistry. Necrosis. alpha-Fetoproteins / metabolism

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  • (PMID = 18046064.001).
  • [ISSN] 0125-9326
  • [Journal-full-title] Acta medica Indonesiana
  • [ISO-abbreviation] Acta Med Indones
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Indonesia
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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7. Abdullah A, Jenkins-Mosure K, Lewis T, Patel Y, Strobel S, Pepe L: Primary hepatoid carcinoma of the biliary tree: a radiologic mimicker of Klatskin-type tumor. Cancer Imaging; 2010;10:198-201
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  • [Title] Primary hepatoid carcinoma of the biliary tree: a radiologic mimicker of Klatskin-type tumor.
  • We report a unique case in the literature of a 67-year-old Caucasian female who presented with obstructive jaundice due to an obstructing mass seen at the common hepatic duct on imaging with no preceding history of cirrhosis and increased serum α-fetoprotein (AFP), in whom a differential diagnosis from cholangiocarcinoma in a non-cirrhotic liver was particularly difficult given the combination of tumor location and solitary nature.
  • [MeSH-major] Adenocarcinoma / radiography. Common Bile Duct Neoplasms / radiography

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  • [Cites] Radiographics. 2001 Oct;21 Spec No:S97-S116 [11598251.001]
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  • (PMID = 20934950.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Other-IDs] NLM/ PMC2999407
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8. Kumar S, Masood N, Shaikh AJ, Valimuhammad AT, Haider G, Lal A, Niamatullah N: Clinical presentation and outcomes of patients with biliary malignancies: the Aga Khan University experience. Asian Pac J Cancer Prev; 2009 Jul-Sep;10(3):463-6
Hazardous Substances Data Bank. FLUOROURACIL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pathological diagnosis was confirmed in 155 (63.2%) patients, adenocarcinoma (94.8%) being the predominant type.
  • Metastasis was seen in 204 (83.3%) patients, with liver and abdominal lymph nodes being the frequent sites of metastasis.
  • Common bile duct stricture was seen in 78 patients and stenting was successful in 73 patients.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bile Duct Neoplasms / drug therapy. Bile Ducts, Intrahepatic / drug effects. Cholangiocarcinoma / drug therapy. Gallbladder Neoplasms / drug therapy. Liver Neoplasms / drug therapy

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  • (PMID = 19640192.001).
  • [ISSN] 2476-762X
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; B76N6SBZ8R / gemcitabine; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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11. Mannai S, Kraïem T, Gharbi L, Haoues N, Mestiri H, Khalfallah MT: [Congenital cystic dilatation of bile ducts]. Ann Chir; 2006 Jul-Aug;131(6-7):369-74
MedlinePlus Health Information. consumer health - Bile Duct Diseases.

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  • [Title] [Congenital cystic dilatation of bile ducts].
  • Congenital cystic dilatation of bile ducts is a rare condition.
  • We report a retrospective study about 18 patients having congenital bile duct cysts.
  • According to Todani's classification, 11 cases were type I and 7 were type V.
  • A total resection of the cyst was conducted in the type I cysts.
  • Anatomopathologic examination showed an adenocarcinoma of a common bile duct cyst.
  • In one case, a cancer of the gall bladder associated to a common bile duct cyst in another case.
  • Three patients with segmental dilatation of intrahepatic bile ducts (type V) underwent liver resection.
  • Congenital cystic dilatation of bile ducts is considered to be a precancer state.
  • [MeSH-major] Bile Duct Diseases / congenital. Bile Ducts / abnormalities. Choledochal Cyst. Cysts / congenital
  • [MeSH-minor] Acute Disease. Adolescent. Adult. Aged. Aged, 80 and over. Anastomosis, Surgical. Bile Ducts, Intrahepatic / abnormalities. Caroli Disease / diagnosis. Caroli Disease / surgery. Child. Child, Preschool. Cholangitis / etiology. Cholecystitis / complications. Dilatation. Dilatation, Pathologic / congenital. Drainage. Female. Hepatectomy. Humans. Jejunum / surgery. Liver / surgery. Male. Middle Aged. Postoperative Complications. Retrospective Studies

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  • (PMID = 16630531.001).
  • [ISSN] 0003-3944
  • [Journal-full-title] Annales de chirurgie
  • [ISO-abbreviation] Ann Chir
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
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12. Lim JH, Jang KT, Choi D: Biliary intraductal papillary-mucinous neoplasm manifesting only as dilatation of the hepatic lobar or segmental bile ducts: imaging features in six patients. AJR Am J Roentgenol; 2008 Sep;191(3):778-82
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  • [Title] Biliary intraductal papillary-mucinous neoplasm manifesting only as dilatation of the hepatic lobar or segmental bile ducts: imaging features in six patients.
  • OBJECTIVE: The purpose of this study was to evaluate the imaging features of intrahepatic biliary intraductal papillary-mucinous neoplasm manifesting only as dilatation of the lobar or segmental bile ducts without a visible mass to determine whether this type of cholangiocarcinoma can be recognized on the basis of distinct imaging features.
  • Severe dilatation of the lobar or segmental intrahepatic bile ducts with crowding and severe atrophy of the hepatic parenchyma are helpful imaging findings.
  • [MeSH-major] Adenocarcinoma, Mucinous / radiography. Adenoma / radiography. Bile Duct Neoplasms / radiography. Liver Diseases / radiography. Tomography, X-Ray Computed / methods

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  • (PMID = 18716109.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Fumino S, Ono S, Shimadera S, Kimura O, Iwai N: Impact of age at diagnosis on clinical features in children with anomalous arrangement of the pancreaticobiliary duct. Eur J Pediatr Surg; 2010 Sep;20(5):325-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Impact of age at diagnosis on clinical features in children with anomalous arrangement of the pancreaticobiliary duct.
  • AIMS: In patients with an anomalous arrangement of the pancreaticobiliary duct (AAPBD), clinical presentations may differ between infants and older children.
  • They included 46 with the cystic type, 33 with the fusiform type, and 6 with the non-dilatation type.
  • In terms of liver histology, liver cirrhosis was observed in 2 infants, one of whom was a 3-month-old girl with severe jaundice resulting in living-donor liver transplantation, despite bile drainage.
  • A single postoperative death occurred due to an adenocarcinoma arising in a choledochal cyst in a 12-year-old girl.
  • CONCLUSIONS: Problems characteristic of infantile AAPBD were a severe bleeding tendency and irreversible liver cirrhosis, which could develop as young as 3 months old.
  • The surgical recommendation for infantile AAPBD is thus early surgery before the age of 3 months to prevent liver failure.
  • [MeSH-major] Bile Ducts / abnormalities. Pancreatic Ducts / abnormalities
  • [MeSH-minor] Age Factors. Age of Onset. Cholangitis / surgery. Choledochal Cyst / diagnosis. Dilatation, Pathologic. Female. Humans. Infant. Infant, Newborn. Liver Cirrhosis / epidemiology. Male. Retrospective Studies

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  • [Copyright] © Georg Thieme Verlag KG Stuttgart · New York.
  • (PMID = 20623446.001).
  • [ISSN] 1439-359X
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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14. Chu PG, Schwarz RE, Lau SK, Yen Y, Weiss LM: Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2. Am J Surg Pathol; 2005 Mar;29(3):359-67
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  • [Title] Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2.
  • Pancreatobiliary and ampulla of Vater adenocarcinomas frequently metastasize to regional lymph nodes, liver, or lung and are difficult to diagnose because they lack specific immunohistochemical markers.
  • The expression of MUC2 and CDX2 was restricted to the intestinal, mucinous, and signet-ring cell-type adenocarcinomas of duodenal papillary origin (9 of 11, 82%; 11 of 11, 100%, respectively).
  • In contrast, all 11 cases of the intestinal, mucinous, and signet-ring cell-type adenocarcinomas of duodenal papillary origin showed homogeneous CDX2 nuclear positivity.
  • MUC2+/CDX2+ can be used as positive markers for the intestinal-type adenocarcinoma of duodenal papillary origin with a positive predictive value of 82%.
  • [MeSH-major] Ampulla of Vater / pathology. Bile Ducts, Intrahepatic / pathology. Carcinoma, Pancreatic Ductal / pathology. Cholangiocarcinoma / pathology. Common Bile Duct Neoplasms / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Biomarkers, Tumor / metabolism. Female. Homeodomain Proteins / metabolism. Humans. Immunohistochemistry. Keratins / metabolism. Male. Mucins / metabolism. Neoplasm Proteins / metabolism

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  • (PMID = 15725805.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / Mucins; 0 / Neoplasm Proteins; 68238-35-7 / Keratins
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15. Shimamura K, Kurosaki I, Sato D, Takano K, Yokoyama N, Sato Y, Hatakeyama K, Nakadaira K, Yagi M: Intrahepatic cholangiocarcinoma arising 34 years after excision of a type IV-A congenital choledochal cyst: report of a case. Surg Today; 2009;39(3):247-51
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  • [Title] Intrahepatic cholangiocarcinoma arising 34 years after excision of a type IV-A congenital choledochal cyst: report of a case.
  • We report a rare case of intrahepatic cholangiocarcinoma (IHCC) arising many years after excision of a type IV-A congenital choledochal cyst.
  • Imaging showed a huge tumor in the left medial section of the liver, extending to the porta hepatis.
  • Although he had no jaundice, the intrahepatic bile ducts showed cylinder-like dilatation with narrowing of the hilar bile duct.
  • At surgery, the tumor was found to arise from the dilated intrahepatic bile duct just above the narrow portion.
  • Microscopically, the tumor was confirmed to be moderate-to-well-differentiated tubular adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / etiology. Bile Duct Neoplasms / diagnosis. Bile Duct Neoplasms / etiology. Bile Ducts, Intrahepatic. Cholangiocarcinoma / etiology. Choledochal Cyst / complications. Choledochal Cyst / surgery

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  • (PMID = 19280286.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 31
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16. Hashimoto T, Minagawa M, Aoki T, Hasegawa K, Sano K, Imamura H, Sugawara Y, Makuuchi M, Kokudo N: Caval invasion by liver tumor is limited. J Am Coll Surg; 2008 Sep;207(3):383-92
MedlinePlus Health Information. consumer health - Liver Cancer.

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  • [Title] Caval invasion by liver tumor is limited.
  • Patient survival rates were examined according to type of tumor and the operative procedure.
  • For adenocarcinoma lesions, several CT findings, including extent of the IVC circumference attached to the tumor compared with the whole IVC circumference (E(IVC)), were evaluated in conjunction with IVC resection.
  • RESULTS: Among 162 lesions, 18 adenocarcinoma lesions were resected in combination with an IVC resection.
  • Overall 5-year survival rate of the patients who underwent concomitant liver and IVC resections was 33.1%.
  • Among the adenocarcinoma lesions, the positive predictive factors for IVC resection were an E(IVC) value > 25% and a peaked deformity of the IVC wall, according to a multivariate analysis.
  • E(IVC) and deformity of the IVC on CT can be useful indicators for a concomitant liver and IVC resection.
  • Careful separation of the liver and IVC is a key point for minimizing the size of the resected IVC and to avoid unnecessary IVC resection.
  • [MeSH-major] Adenocarcinoma / pathology. Bile Duct Neoplasms / pathology. Carcinoma, Hepatocellular / pathology. Cholangiocarcinoma / pathology. Cystadenocarcinoma / pathology. Liver Neoplasms / pathology. Vena Cava, Inferior / pathology

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  • (PMID = 18722944.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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17. Miwa S, Miyagawa S, Kobayashi A, Akahane Y, Nakata T, Mihara M, Kusama K, Soeda J, Ogawa S: Predictive factors for intrahepatic cholangiocarcinoma recurrence in the liver following surgery. J Gastroenterol; 2006 Sep;41(9):893-900
MedlinePlus Health Information. consumer health - Bile Duct Cancer.

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  • [Title] Predictive factors for intrahepatic cholangiocarcinoma recurrence in the liver following surgery.
  • BACKGROUND: We performed hepatectomy without lymph node (LN) dissection for intrahepatic cholangiocarcinoma (ICC) limited to the peripheral region of the liver, and hepatectomy with extrahepatic bile duct resection and regional LN dissection for any types of ICC extending to the hepatic hilum.
  • RESULTS: Significant risk factors for poorer survival included preoperative jaundice (P = 0.0115), serum CA19-9 levels >37 U/ml (P = 0.0089), tumor diameter >4.5 cm (P = 0.017), ICC extending to the hepatic hilum (P = 0.0065), mass-forming with periductal-infiltrating type (P = 0.003), poorly differentiated adenocarcinoma, portal vein involvement (P = 0.0785), LN metastasis at initial hepatectomy (P < 0.0001), and positive surgical margin (P = 0.023).
  • [MeSH-major] Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic. Cholangiocarcinoma / surgery. Hepatectomy. Neoplasm Recurrence, Local / epidemiology

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  • [CommentIn] J Gastroenterol. 2006 Sep;41(9):925-6 [17048061.001]
  • (PMID = 17048054.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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18. Shirabe K, Mano Y, Taketomi A, Soejima Y, Uchiyama H, Aishima S, Kayashima H, Ninomiya M, Maehara Y: Clinicopathological prognostic factors after hepatectomy for patients with mass-forming type intrahepatic cholangiocarcinoma: relevance of the lymphatic invasion index. Ann Surg Oncol; 2010 Jul;17(7):1816-22
MedlinePlus Health Information. consumer health - Liver Cancer.

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  • [Title] Clinicopathological prognostic factors after hepatectomy for patients with mass-forming type intrahepatic cholangiocarcinoma: relevance of the lymphatic invasion index.
  • BACKGROUND: The present study was conducted to clarify the pathological factors in patients who underwent surgery for mass-forming type intrahepatic cholangiocarcinoma (IHC).
  • METHODS: From 1982 to July 2004, a total of 60 liver resections for mass-forming type IHC were performed at Kyushu University and its affiliated institutions.
  • The lymphatic invasion (LI) index was defined as follows: LI0, lymphatic duct invasion (-) and lymph node metastasis (-); LI1, intrahepatic lymphatic duct invasion (+) or lymph node metastasis (+); LI2, intrahepatic lymphatic duct invasion (+) and lymph node metastasis (+).
  • CONCLUSIONS: In patients with mass-forming type IHC, lymphatic invasion is the most important invasion pathway, compared with serosal and portal and hepatic venous invasion.
  • Stratification of the lymphatic invasion pathway by lymphatic invasion, including intrahepatic lymphatic duct invasion and lymph node metastasis, is a good predictor for prognosis in patients after hepatectomy for mass-forming type IHC.
  • [MeSH-major] Adenocarcinoma / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / pathology. Hepatectomy. Liver Neoplasms / secondary

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  • (PMID = 20135355.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Chiu CT, Chiang JM, Yeh TS, Tseng JH, Chen TC, Jan YY, Chen MF: Clinicopathological analysis of colorectal cancer liver metastasis and intrahepatic cholangiocarcinoma: are they just apples and oranges? Dig Liver Dis; 2008 Sep;40(9):749-54
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  • [Title] Clinicopathological analysis of colorectal cancer liver metastasis and intrahepatic cholangiocarcinoma: are they just apples and oranges?
  • BACKGROUNDS/AIMS: Intrahepatic cholangiocarcinoma and colorectal cancer liver metastasis are the most primary and secondary adenocarcinoma of the liver, respectively.
  • METHODS: A total of 166 colorectal cancer liver metastasis patients and 206 intrahepatic cholangiocarcinoma patients who had undergone curative liver resection were retrospectively analysed.
  • Among 206 intrahepatic cholangiocarcinoma, there were 47 intraductal growth type-intrahepatic cholangiocarcinoma and 159 non-intraductal growth type-intrahepatic cholangiocarcinoma.
  • RESULTS: The intrahepatic cholangiocarcinoma patients were more female-predominated, associated with hepatolithiasis, symptomatic, jaundiced, and with larger tumour size compared with those of colorectal cancer liver metastasis.
  • Prognostic factors of intrahepatic cholangiocarcinoma were pathologic staging, histologic pattern and section margin; whereas prognostic factors of colorectal cancer liver metastasis were rectal origin, differentiation, section margin and bilobar distribution.
  • CK7 and CK20 differentiated majority of intrahepatic cholangiocarcinoma from colorectal cancer liver metastasis, while CDX2 and MUC5AC helped to differentiate inconclusive cases.
  • The 1-, 3-, 5- and 10-year survival rates of colorectal cancer liver metastasis were 77%, 31%, 20% and 14%, compared to 53%, 21%, 13% and 7% of intrahepatic cholangiocarcinoma (p=.0001).
  • Furthermore, the survival of colorectal cancer liver metastasis was comparable to staged II intrahepatic cholangiocarcinoma (p=.8866) and intraductal growth type-intrahepatic cholangiocarcinoma (p=.1915).
  • CONCLUSIONS: Demographics, precipitating factor, clinical manifestations, and prognostic factors of colorectal cancer liver metastasis and intrahepatic cholangiocarcinoma differed remarkably.
  • High incidence of CDX2 and MUC2 expression in colorectal cancer liver metastasis and intraductal growth type-intrahepatic cholangiocarcinoma might explain their similar cytoarchitecture and survival.
  • [MeSH-major] Adenocarcinoma / secondary. Bile Duct Neoplasms / pathology. Biomarkers, Tumor / analysis. Cholangiocarcinoma / pathology. Colorectal Neoplasms / pathology. Liver Neoplasms / secondary
  • [MeSH-minor] Aged. Bile Ducts, Intrahepatic. Biopsy, Needle. Cohort Studies. Female. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Probability. Prognosis. Retrospective Studies. Risk Assessment. Statistics, Nonparametric. Survival Analysis


20. Shimizu T, Shigemasa Y, Kajiwara K, Sasaki N, Ikari H, Kunizaki T, Yonemitsu N: [A case of radiation therapy successfully treated liver and lung tumors arising from postoperative cecum cancer]. Gan To Kagaku Ryoho; 2009 Nov;36(12):2149-51
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  • [Title] [A case of radiation therapy successfully treated liver and lung tumors arising from postoperative cecum cancer].
  • The patient was an 85-year-old man who underwent a rt-hemicolectomy, cholecystectomy and choledocholithotomy for cecum cancer and bile duct stone.
  • The tumor was a well differentiated adenocarcinoma, type 2 in the Japanese classification of colorectal carcinoma.
  • We diagnosed with liver metastasis of the cecum cancer.
  • We chose radiotherapy for liver metastasis.
  • There has been no liver recurrence.
  • If the case was made a good choice, radiation therapy appears to be effective for liver and lung tumors from the colorectal cancer.
  • [MeSH-major] Adenocarcinoma / surgery. Cecal Neoplasms / surgery. Liver Neoplasms / radiotherapy. Liver Neoplasms / secondary. Lung Neoplasms / radiotherapy. Lung Neoplasms / secondary

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  • (PMID = 20037352.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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21. Testoni PA, Mangiavillano B, Mariani A, Carrara S, Notaristefano C, Arcidiacono PG: Investigation of Oddi sphincter structure by optical coherence tomography in patients with biliary-type 1 dysfunction: a pilot in vivo study. Dig Liver Dis; 2009 Dec;41(12):907-12

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  • [Title] Investigation of Oddi sphincter structure by optical coherence tomography in patients with biliary-type 1 dysfunction: a pilot in vivo study.
  • BACKGROUND: Type 1 sphincter of Oddi dysfunction is a clinical entity characterised by biliary-type pain, elevated liver biochemical tests, and common bile duct dilation.
  • Sphincter fibrosis is a common finding in this type of dysfunction and may require in some cases a differential diagnosis with a malignant intra-papillary disease.
  • Optical coherence tomography permits high-resolution, real-time imaging of the sphincter of Oddi microstructure by a probe inserted into the common bile duct through an ERCP catheter.
  • OBJECTIVE: To assess the feasibility of optical coherence tomography investigation of the sphincter of Oddi structure and assess its potential for diagnosing type 1 sphincter of Oddi dysfunction.
  • PATIENTS: Ten consecutive patients, five with biliary-type 1 sphincter of Oddi dysfunction and five with pancreatic head/mid-body adenocarcinoma not involving the papillary region, who underwent both endoscopic ultrasound and therapeutic ERCP, were investigated by optical coherence tomography immediately before biliary sphincterotomy or stenting.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / physiopathology. Aged. Cholangiopancreatography, Endoscopic Retrograde. Diagnosis, Differential. Feasibility Studies. Female. Humans. Male. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / physiopathology. Pilot Projects

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  • (PMID = 19403347.001).
  • [ISSN] 1878-3562
  • [Journal-full-title] Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • [ISO-abbreviation] Dig Liver Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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22. Ishibashi Y, Ojima H, Hiraoka N, Sano T, Kosuge T, Kanai Y: Invasive biliary cystic tumor without ovarian-like stroma. Pathol Int; 2007 Dec;57(12):794-8
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  • A 54-year-old woman was incidentally diagnosed as having a cystic tumor in segment VIII of the liver, and central bisegmentectomy was performed.
  • Microscopically the tumor showed three types of neoplasia: adenoma and tubulopapillary adenocarcinoma in the cystic area, and invasive adenocarcinoma in the solid area.
  • Moreover, transitional zones between adenoma and tubulopapillary adenocarcinoma, and between tubulopapillary adenocarcinoma and invasive adenocarcinoma were noted.
  • The immunohistochemical expression of Ki-67 and p53 increased gradually from adenoma through to tubulopapillary adenocarcinoma, and was highest in invasive adenocarcinoma.
  • No ovarian-like stroma or communication with the bile ducts around the tumor was found in any area of the specimen.
  • On the basis of the World Health Organization histological classification and these pathological findings, the present case was diagnosed as invasive-type biliary cystadenocarcinoma.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Cell Transformation, Neoplastic / pathology. Cystadenocarcinoma / pathology. Ovary / pathology. Stromal Cells / pathology
  • [MeSH-minor] Adenocarcinoma, Papillary / metabolism. Adenocarcinoma, Papillary / pathology. Adenoma / metabolism. Adenoma / pathology. Female. Humans. Hypertension / pathology. Immunohistochemistry. Incidental Findings. Ki-67 Antigen / biosynthesis. Middle Aged. Mucin-1 / biosynthesis. Tumor Suppressor Protein p53 / biosynthesis

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  • (PMID = 17988281.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Mucin-1; 0 / Tumor Suppressor Protein p53
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23. Itatsu K, Zen Y, Ohira S, Ishikawa A, Sato Y, Harada K, Ikeda H, Sasaki M, Nimura Y, Nakanuma Y: Immunohistochemical analysis of the progression of flat and papillary preneoplastic lesions in intrahepatic cholangiocarcinogenesis in hepatolithiasis. Liver Int; 2007 Nov;27(9):1174-84
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  • BACKGROUND: Two types of precursor lesions, flat-type 'biliary intraepithelial neoplasia (BilIN)' and papillary-type 'intraductal papillary neoplasm of the bile duct (IPNB)', are proposed in the tumorigenesis of intrahepatic cholangiocarcinoma (ICC) in hepatolithiasis.
  • The expression of E-cadherin, beta-catenin, matrix metalloproteinase-7 (MMP-7), membrane type 1-MMP (MT1-MMP), cyclin D1 and c-myc was immunohistochemically examined.
  • [MeSH-major] Adenocarcinoma, Papillary / metabolism. Bile Duct Neoplasms / metabolism. Biomarkers, Tumor / metabolism. Cholangiocarcinoma / metabolism. Cholelithiasis / metabolism. Precancerous Conditions / metabolism
  • [MeSH-minor] Aged. Aged, 80 and over. Bile Ducts, Intrahepatic / metabolism. Bile Ducts, Intrahepatic / pathology. Cadherins / metabolism. Cyclin D. Cyclins / metabolism. Disease Progression. Disease-Free Survival. Female. Humans. Immunoenzyme Techniques. Male. Matrix Metalloproteinase 14 / metabolism. Matrix Metalloproteinase 7 / metabolism. Middle Aged. Proto-Oncogene Proteins c-myc / metabolism. beta Catenin / metabolism

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  • (PMID = 17919228.001).
  • [ISSN] 1478-3223
  • [Journal-full-title] Liver international : official journal of the International Association for the Study of the Liver
  • [ISO-abbreviation] Liver Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins; 0 / Cyclin D; 0 / Cyclins; 0 / MYC protein, human; 0 / Proto-Oncogene Proteins c-myc; 0 / beta Catenin; EC 3.4.24.23 / MMP7 protein, human; EC 3.4.24.23 / Matrix Metalloproteinase 7; EC 3.4.24.80 / MMP14 protein, human; EC 3.4.24.80 / Matrix Metalloproteinase 14
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24. Kitami CE, Kurosaki I, Koyama Y, Makino H, Hatakeyama K: Long-term survival after hepatectomy for hepatic recurrence of carcinoma of the papilla of Vater. J Hepatobiliary Pancreat Surg; 2005;12(4):321-3
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  • We present herein a rare case of a long-term survivor after major hepatectomy performed for a metastatic liver tumor from carcinoma of the papilla of Vater.
  • Histologically, an exposed mass-forming type of tumor, measuring 40 x 30 mm, was composed of mucinous and papillary adenocarcinoma, invading into the muscularis propria of the duodenum, without lymph node metastases.
  • The patient did not receive any type of chemotherapy.
  • In September 1999, a solitary hepatic tumor, 3.5 cm in diameter, was detected in segment VIII of the liver by computed tomography.
  • [MeSH-major] Adenocarcinoma, Mucinous / surgery. Adenocarcinoma, Papillary / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / pathology. Hepatectomy. Liver Neoplasms / secondary. Liver Neoplasms / surgery

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  • (PMID = 16133701.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; 1-UFT protocol
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25. Khunamornpong S, Siriaunkgul S, Suprasert P, Pojchamarnwiputh S, Na Chiangmai W, Young RH: Intrahepatic cholangiocarcinoma metastatic to the ovary: a report of 16 cases of an underemphasized form of secondary tumor in the ovary that may mimic primary neoplasia. Am J Surg Pathol; 2007 Dec;31(12):1788-99
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  • The potential for adenocarcinoma metastatic to the ovary to mimic primary mucinous neoplasms is a well-known issue to surgical pathologists, most of the recent literature emphasizing pancreatic and various other origins for the ovarian metastases.
  • Although an origin in the gallbladder or extrahepatic bile ducts is acknowledged for some cases little information exists on tumors originating within the intrahepatic bile ducts.
  • Sixteen cases of this type were retrieved from the surgical pathology files of the Chiang Mai University Hospital between January 1992 and December 2006.
  • Foci often mimicked mucinous borderline tumors of typical type or with intraepithelial carcinoma and benign-appearing mucinous epithelium was seen in 62% of tumors.
  • Intrahepatic cholangiocarcinoma should be included in the list of origins of possible ovarian metastatic tumors that mimic primary ovarian mucinous neoplasia, particularly in parts of the world where cholangiocarcinoma of the liver is relatively common.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Cholangiocarcinoma / secondary. Ovarian Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Bile Ducts, Intrahepatic / pathology. Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 18043033.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Ishimura N, Bronk SF, Gores GJ: Inducible nitric oxide synthase up-regulates Notch-1 in mouse cholangiocytes: implications for carcinogenesis. Gastroenterology; 2005 May;128(5):1354-68
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  • METHODS: Notch receptor and ligand expression in human liver was evaluated by immunohistochemistry.
  • The colocalization of Notch-1 and iNOS also was observed in large bile ducts from the hilar region of primary sclerosing cholangitis patients.
  • [MeSH-major] Adenocarcinoma / metabolism. Bile Duct Neoplasms / metabolism. Nitric Oxide Synthase / metabolism. Receptors, Cell Surface / genetics. Transcription Factors / genetics
  • [MeSH-minor] Amyloid Precursor Protein Secretases. Animals. Aspartic Acid Endopeptidases. Bile Ducts / cytology. Cell Line, Transformed. Cholangitis, Sclerosing / metabolism. Cholangitis, Sclerosing / physiopathology. Endopeptidases / metabolism. Gene Expression Regulation, Enzymologic. Gene Expression Regulation, Neoplastic. Humans. Mice. Mitogen-Activated Protein Kinase 8 / metabolism. Mitogen-Activated Protein Kinase 9 / metabolism. Nitric Oxide Donors / pharmacology. Nitric Oxide Synthase Type II. Phenotype. Receptor, Notch1. S-Nitrosoglutathione / pharmacology. Signal Transduction / physiology. Up-Regulation

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  • (PMID = 15887117.001).
  • [ISSN] 0016-5085
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / NOTCH1 protein, human; 0 / Nitric Oxide Donors; 0 / Notch1 protein, mouse; 0 / Receptor, Notch1; 0 / Receptors, Cell Surface; 0 / Transcription Factors; 57564-91-7 / S-Nitrosoglutathione; EC 1.14.13.39 / NOS2 protein, human; EC 1.14.13.39 / Nitric Oxide Synthase; EC 1.14.13.39 / Nitric Oxide Synthase Type II; EC 1.14.13.39 / Nos2 protein, mouse; EC 2.7.1.24 / Mitogen-Activated Protein Kinase 9; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 8; EC 3.4.- / Amyloid Precursor Protein Secretases; EC 3.4.- / Endopeptidases; EC 3.4.23.- / Aspartic Acid Endopeptidases; EC 3.4.23.46 / BACE1 protein, human; EC 3.4.23.46 / Bace1 protein, mouse
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27. Robles R, Marín C, Abellán B, López-Conesa A, Ramírez P, Parrilla P: [Right hepatectomy and left hepatectomy performed via hand-assisted laparoscopic surgery. Description of an original technique]. Cir Esp; 2006 Nov;80(5):326-30
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  • INTRODUCTION: Laparoscopic liver surgery in solid tumors presents a number of difficulties.
  • This type of surgery is indicated especially in tumors of less than 5 cm located in the left lobe and in anterior segments of the right lobe.
  • Access to posterior lesions of the right lobe (segments VII and VIII) and performing major regulated hepatectomies (more than 3 segments) are at present difficult for liver surgeons.
  • PATIENTS AND METHOD: RH was performed in a 70-year-old man with hepatic metastases from colorectal carcinoma (pT2N0M1 sigmoid adenocarcinoma).
  • Division of the bile duct and suprahepatic veins was performed with a vascular endostapler.
  • CONCLUSIONS: HALS allows major liver resections to be performed with low morbidity and mortality and with the advantages of laparoscopic surgery.
  • [MeSH-major] Adenocarcinoma / secondary. Colorectal Neoplasms / pathology. Hemangioma / pathology. Hepatectomy / methods. Liver Neoplasms / secondary

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  • (PMID = 17192208.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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28. Kitagawa D, Taketomi A, Aishima S, Kuroda Y, Gion T, Shirabe K, Shimada M, Maehara Y: Recurrence of intrahepatic cholangiocarcinoma nine years after surgical resection. Hepatogastroenterology; 2008 May-Jun;55(84):1085-8
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  • The patient underwent right hepatic trisegmentectomy with lymph node dissection and biliary tract reconstruction for a tumor in the right lobe of the liver.
  • The patient was diagnosed with ICC, intraductal growth (IG) type.
  • Nine years after the operation a rise of tumor markers and a recurrent lesion in the remnant liver were recognized and the patient underwent S2 subsegmentectomy with tumor thrombectomy and biliary tract reconstruction.
  • The resected specimen showed well differentiated adenocarcinoma, which consisted of chiefly intraductal growth component.
  • It is important to observe the patient carefully cosidering that it is possible for an IG type cholangiocarcinoma to recur a long time after surgical treatment, and surgical treatment for the recurrent tumor should be tried for long survival.
  • [MeSH-major] Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic / surgery. Cholangiocarcinoma / surgery. Neoplasm Recurrence, Local / surgery
  • [MeSH-minor] Antigens, Neoplasm / blood. Biomarkers, Tumor / blood. Diagnosis, Differential. Female. Follow-Up Studies. Hepatectomy. Humans. Liver Function Tests. Lymph Node Excision. Middle Aged. Reoperation. Tomography, X-Ray Computed

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  • (PMID = 18705334.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / DU-PAN-2 antigen, human; 0 / pancreatic associated antigen, SPan-1
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29. Ushiku T, Shinozaki A, Shibahara J, Iwasaki Y, Tateishi Y, Funata N, Fukayama M: SALL4 represents fetal gut differentiation of gastric cancer, and is diagnostically useful in distinguishing hepatoid gastric carcinoma from hepatocellular carcinoma. Am J Surg Pathol; 2010 Apr;34(4):533-40
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  • It was also identified by tissue microarray study in a fraction of gastric carcinomas (51 of 338, 15%), associated with older age (P=0.0001), male sex (P=0.0033), intestinal-type histology (P=0.0001), and synchronous liver metastasis (P=0.0047).
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Hepatocellular / diagnosis. Hepatoblastoma / diagnosis. Liver Neoplasms / diagnosis. Stomach Neoplasms / diagnosis. Transcription Factors / metabolism
  • [MeSH-minor] Aged. Bile Duct Neoplasms / diagnosis. Bile Duct Neoplasms / metabolism. Bile Ducts, Intrahepatic / pathology. Biomarkers, Tumor / metabolism. Cholangiocarcinoma / diagnosis. Cholangiocarcinoma / metabolism. Diagnosis, Differential. Female. Fetus / embryology. Fetus / metabolism. Gestational Age. Glypicans / metabolism. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Stomach / embryology. Stomach / metabolism. Tissue Array Analysis. alpha-Fetoproteins / metabolism

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  • (PMID = 20182341.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glypicans; 0 / SALL4 protein, human; 0 / Transcription Factors; 0 / alpha-Fetoproteins
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30. Okamura N, Yoshida M, Shibuya A, Sugiura H, Okayasu I, Ohbu M: Cellular and stromal characteristics in the scirrhous hepatocellular carcinoma: comparison with hepatocellular carcinomas and intrahepatic cholangiocarcinomas. Pathol Int; 2005 Nov;55(11):724-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma, Scirrhous / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Carcinoma, Hepatocellular / pathology. Cholangiocarcinoma / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Aged. Apoptosis. Cell Proliferation. Collagen Type I / analysis. Collagen Type I / immunology. Collagen Type III / analysis. Collagen Type III / immunology. Female. Fibroblast Growth Factor 2 / analysis. Fibroblast Growth Factor 2 / immunology. Humans. Keratins / analysis. Keratins / immunology. Laminin / analysis. Laminin / immunology. Male. Matrix Metalloproteinase 7 / analysis. Matrix Metalloproteinase 7 / immunology. Middle Aged. Tenascin / analysis. Tenascin / immunology

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  • (PMID = 16271085.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Collagen Type I; 0 / Collagen Type III; 0 / Laminin; 0 / Tenascin; 103107-01-3 / Fibroblast Growth Factor 2; 68238-35-7 / Keratins; EC 3.4.24.23 / Matrix Metalloproteinase 7
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31. Zong GQ, Liu XS, Wang F, Gong CH: [Surgical treatment result of hilar cholangiocarcinoma: report of 84 patients]. Zhonghua Zhong Liu Za Zhi; 2007 Apr;29(4):312-5
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  • RESULTS: According to the Bismuth-Corlette staging system, 7 were type I, 18 type II, 22 type II a, 12 type IlI b, 20 type IV and 5 unclassified.
  • Skeletonization of hepatoduodenal ligament with partial liver resection can improve the rate of radical resection for hilar cholangiocarcinoma.
  • [MeSH-major] Adenocarcinoma / surgery. Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic. Biliary Tract Surgical Procedures / methods. Cholangiocarcinoma / surgery
  • [MeSH-minor] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / surgery. Adult. Aged. Aged, 80 and over. Drainage / methods. Female. Humans. Male. Middle Aged. Retrospective Studies. Survival Analysis

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  • (PMID = 17760264.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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32. Yaman B, Nart D, Yilmaz F, Coker A, Zeytunlu M, Kilic M: Biliary intraductal papillary mucinous neoplasia: three case reports. Virchows Arch; 2009 May;454(5):589-94
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  • Intraductal-growing type is an entity described in recent years as mucin-producing intrahepatic cholangiocarcinoma or intrahepatic (biliary) intraductal papillary mucinous neoplasia (b-IPMN).
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Carcinoma, Papillary / pathology. Cholangiocarcinoma / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Carcinoma in Situ / metabolism. Carcinoma in Situ / pathology. Carcinoma in Situ / surgery. Disease-Free Survival. Hepatitis B / complications. Hepatitis B / surgery. Humans. Immunoenzyme Techniques. Liver Cirrhosis / surgery. Liver Cirrhosis / virology. Liver Transplantation. Male. Middle Aged. Mucin 5AC / metabolism. Mucin-1 / metabolism. Pancreatic Neoplasms / metabolism. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / surgery. Treatment Outcome

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  • (PMID = 19347361.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MUC1 protein, human; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucin-1
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33. Weston BR, Ross WA, Wolff RA, Evans D, Lee JE, Wang X, Xiao LC, Lee JH: Rate of bilirubin regression after stenting in malignant biliary obstruction for the initiation of chemotherapy: how soon should we repeat endoscopic retrograde cholangiopancreatography? Cancer; 2008 Jun;112(11):2417-23
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  • Patient variables included type of cancer, liver metastasis, recent chemotherapy, baseline creatinine, and international normalized ratio (INR).
  • Stent variables included type, dimension, stricture location, and sphincterotomy.
  • The following variables were identified as statistically significant: prestent bilirubin level, stricture location, liver metastasis, and INR.
  • The cancer type, recent chemotherapy, stent type and diameter, and sphincterotomy were not statistically significant variables.
  • Independent variables, such as diffuse liver metastases, stricture outside the common bile duct, and elevated INR had predictive value for bilirubin normalization.
  • [MeSH-minor] Adenocarcinoma / blood. Adenocarcinoma / secondary. Adult. Aged. Aged, 80 and over. Cholangiocarcinoma / blood. Cholangiocarcinoma / secondary. Female. Humans. Liver Neoplasms / secondary. Male. Middle Aged. Prognosis. Retrospective Studies

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  • [Copyright] (c) 2008 American Cancer Society.
  • (PMID = 18404695.001).
  • [ISSN] 1097-0142
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] RFM9X3LJ49 / Bilirubin
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34. Nishino R, Honda M, Yamashita T, Takatori H, Minato H, Zen Y, Sasaki M, Takamura H, Horimoto K, Ohta T, Nakanuma Y, Kaneko S: Identification of novel candidate tumour marker genes for intrahepatic cholangiocarcinoma. J Hepatol; 2008 Aug;49(2):207-16
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  • RESULTS: A comparison of the two libraries revealed distinct gene expression patterns for each type of liver cancer.
  • Moreover, discrimination analysis revealed that a combination of these genes could be used to distinguish ICC from HCC or metastatic adenocarcinoma.
  • CONCLUSIONS: We identified novel marker genes of ICC that are potentially useful for the diagnosis of liver cancer.
  • [MeSH-major] Bile Duct Neoplasms / genetics. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Biomarkers, Tumor / genetics. Cholangiocarcinoma / genetics. Cholangiocarcinoma / pathology

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  • [CommentIn] J Hepatol. 2008 Aug;49(2):160-2 [18538440.001]
  • (PMID = 18490072.001).
  • [ISSN] 0168-8278
  • [Journal-full-title] Journal of hepatology
  • [ISO-abbreviation] J. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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35. Wernicke J, Pangallo B, Wang F, Murray I, Henck JW, Knadler MP, D'Souza DN, Uetrecht JP: Hepatic effects of duloxetine-I: non-clinical and clinical trial data. Curr Drug Saf; 2008 May;3(2):132-42
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  • Seven of 23,000 duloxetine- and 2/6000 placebo-treated patients met criteria for modified Hy's rule (significant elevation of both ALT and total bilirubin) but were complicated by contributing factors such as excessive alcohol consumption (n=3), gall stones, common bile duct calculus, hepatitis C, and liver adenocarcinoma (n=1 each).
  • CONCLUSIONS: Duloxetine has an effect on the liver, manifested by transient, self-limiting transaminase elevations.
  • Rare events characterized as hepatocellular injury, cholestatic injury, or mixed type of hepatic injury have been reported.
  • The pattern of liver effects was different from that in laboratory animals.
  • [MeSH-major] Adrenergic Uptake Inhibitors / adverse effects. Drug-Induced Liver Injury. Liver / drug effects. Serotonin Uptake Inhibitors / adverse effects. Thiophenes / adverse effects
  • [MeSH-minor] Alanine Transaminase / blood. Alkaline Phosphatase / blood. Animals. Aspartate Aminotransferases / blood. Bilirubin / blood. Biomarkers / blood. Clinical Trials as Topic. Consumer Product Safety. Drug Evaluation, Preclinical. Duloxetine Hydrochloride. Humans. Liver Diseases / enzymology. Risk Assessment. Risk Factors. Species Specificity

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  • [ErratumIn] Curr Drug Saf. 2009 Jan;4(1):94
  • (PMID = 18690991.001).
  • [ISSN] 2212-3911
  • [Journal-full-title] Current drug safety
  • [ISO-abbreviation] Curr Drug Saf
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United Arab Emirates
  • [Chemical-registry-number] 0 / Adrenergic Uptake Inhibitors; 0 / Biomarkers; 0 / Serotonin Uptake Inhibitors; 0 / Thiophenes; 9044SC542W / Duloxetine Hydrochloride; EC 2.6.1.1 / Aspartate Aminotransferases; EC 2.6.1.2 / Alanine Transaminase; EC 3.1.3.1 / Alkaline Phosphatase; RFM9X3LJ49 / Bilirubin
  • [Number-of-references] 30
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36. Morak MJ, van der Gaast A, Incrocci L, van Dekken H, Hermans JJ, Jeekel J, Hop WC, Kazemier G, van Eijck CH: Adjuvant intra-arterial chemotherapy and radiotherapy versus surgery alone in resectable pancreatic and periampullary cancer: a prospective randomized controlled trial. Ann Surg; 2008 Dec;248(6):1031-41
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  • Groups were stratified for tumor type (pancreatic vs. periampullary tumors).
  • Subgroup analysis showed significantly less liver metastases after adjuvant treatment in periampullary tumors (log-rank P < 0.03) without effect on local recurrence.
  • In patients with pancreatic cancer, CAI/RT had no significant effect on local recurrence (log-rank P = 0.12) neither on the development of liver metastases (log-rank P = 0.76) and consequently, no effect on overall survival.
  • For periampullary tumors, CAI/RT induced a significant reduction in the development of liver metastases, with a possible effect on overall survival.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / therapy. Ampulla of Vater. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Common Bile Duct Neoplasms / mortality. Common Bile Duct Neoplasms / surgery. Common Bile Duct Neoplasms / therapy. Fluorouracil / administration & dosage. Mitoxantrone / administration & dosage. Pancreatic Neoplasms / mortality. Pancreatic Neoplasms / therapy

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  • (PMID = 19092348.001).
  • [ISSN] 1528-1140
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Sulfides; 0TQU7668EI / Cycloleucine; 2425D15SYM / lead sulfide; 2P299V784P / Lead; 3814-46-8 / cispentacin; BZ114NVM5P / Mitoxantrone; U3P01618RT / Fluorouracil
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37. Esposito I, Schirmacher P: Pathological aspects of cholangiocarcinoma. HPB (Oxford); 2008;10(2):83-6
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  • Cholangiocarcinoma (CC) arises from the biliary epithelium and in most cases represents adenocarcinoma.
  • Morphological subtyping (histotype; hilar vs peripheral type), TNM classification, lymphatic spread, and resection margin status are of prognostic relevance.

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  • (PMID = 18773061.001).
  • [ISSN] 1365-182X
  • [Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association
  • [ISO-abbreviation] HPB (Oxford)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2504382
  • [Keywords] NOTNLM ; Bile duct / bile duct cancer / cholangiocarcinoma / histopathology / resection margin
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