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The genetic resources include cloned DNAs, gene libraries (e.g., cDNA and genomic DNA cloned into phage, cosmid, BAC, phosmid, and YAC), vectors, hosts, recombinant viruses, and ordered library sets derived from animal cells, including human and mouse cells, microorganisms, and viruses.

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(PMID = 20484845.001).

[ISSN] 1881-7122

[Journal-full-title] Experimental animals

[ISO-abbreviation] Exp. Anim.

[Language] ENG

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review

[Publication-country] Japan

[Number-of-references] 34

   

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Two TLR1 loci were identified from a rainbow trout bacterial artificial chromosome (BAC) library using DNA sequencing and genetic linkage analyses.

Full length cDNA clone and direct sequencing of four BACs revealed an intact omTLR1 open reading frame (ORF) located on chromosome 14 and a second locus on chromosome 25 that contains a TLR1 pseudogene.

However, due to the lack of TLR6 and 10 genes in teleost genomes and up-regulation of TLR1 mRNA in response to LPS and bacterial infection in other fish species we hypothesize an important role for omTLR1 in anti-microbial immunity.

Therefore, the identification of a TLR2 ortholog in rainbow trout and the development of assays to measure ligand binding and downstream signaling are critical for future elucidation of omTLR1 functions.

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ZFIN. ZFIN .

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[Copyright] Published by Elsevier Ltd.

(PMID = 20153434.001).

[ISSN] 1095-9947

[Journal-full-title] Fish & shellfish immunology

[ISO-abbreviation] Fish Shellfish Immunol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Chemical-registry-number] 0 / RNA, Messenger; 0 / Toll-Like Receptor 1

   

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The basic helix-loop-helix (bHLH) transcription factor Math5 (Atoh7) is required for retinal ganglion cell (RGC) and optic nerve development.

Math5 expression in the CN was verified by mRNA in situ hybridization, and the identity of positive neurons was confirmed morphologically using a Math5-Cre BAC transgene with an alkaline phosphatase reporter.

These temporal changes are consistent with a higher-level auditory processing disorder involving the CN, potentially affecting the integration of binaural sensory information.

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(PMID = 17977745.001).

[ISSN] 1044-7431

[Journal-full-title] Molecular and cellular neurosciences

[ISO-abbreviation] Mol. Cell. Neurosci.

[Language] ENG

[Grant] United States / NIGMS NIH HHS / GM / R01 GM067840-04; United States / NIDDK NIH HHS / DK / P60 DK20572; United States / NIDCD NIH HHS / DC / R01 DC04825; United States / NEI NIH HHS / EY / T32 EY013934; United States / NIGMS NIH HHS / GM / T32 GM07544; United States / NIDCD NIH HHS / DC / P30 DC005188; United States / NIGMS NIH HHS / GM / R01 GM067840; United States / NIDDK NIH HHS / DK / P60 DK020572; United States / NEI NIH HHS / EY / R01 EY14259; United States / NEI NIH HHS / EY / R01 EY014259-03; United States / NEI NIH HHS / EY / EY014259-03; United States / NIGMS NIH HHS / GM / GM067840-04; United States / NIDCD NIH HHS / DC / T32 DC00011; United States / NIGMS NIH HHS / GM / T32 GM007544; United States / NEI NIH HHS / EY / R01 EY014259; United States / NIDCD NIH HHS / DC / P30 DC05188; United States / NIDCD NIH HHS / DC / T32 DC000011; United States / NIDCD NIH HHS / DC / R01 DC004825

[Publication-type] Journal Article; Research Support, N.I.H., Extramural

[Publication-country] United States

[Chemical-registry-number] 0 / 2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt; 0 / Atoh7 protein, mouse; 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Nerve Tissue Proteins; 0 / RNA, Messenger; 0 / Stilbamidines; EC 3.2.1.23 / beta-Galactosidase; G34N38R2N1 / Bromodeoxyuridine

[Other-IDs] NLM/ NIHMS38894; NLM/ PMC2266824

   

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The aims of present study were to clinically and molecularly characterize the syndrome further in seven subjects with de novo 18p deletions and to perform genotype-phenotype correlation.

All seven subjects had terminal deletions and no interstitial deletion was observed with subtelomeric FISH analyses.

To define the extent of the 18p deletions and the parental origin of the deletion microsatellite- and FISH analyses were performed on genomic DNA and on lymphoblastoid cell lines of the study participants.

Totally 19 chromosomes, 18 specific polymorphic microsatellite markers, and 5 BAC clones were used.

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[Copyright] Copyright 2006 Wiley-Liss, Inc.

(PMID = 16691587.001).

[ISSN] 1552-4825

[Journal-full-title] American journal of medical genetics. Part A

[ISO-abbreviation] Am. J. Med. Genet. A

[Language] eng

[Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

   

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[Title] Vorinostat increases carboplatin and paclitaxel activity in non-small-cell lung cancer cells.

We observed a 53% response rate in non-small cell lung cancer (NSCLC) patients treated with vorinostat plus paclitaxel/carboplatin in a Phase I trial.

Vorinostat addition to carboplatin or paclitaxel led to significantly greater growth inhibition than chemotherapy alone in all 4 cell lines.

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(PMID = 19621389.001).

[ISSN] 1097-0215

[Journal-full-title] International journal of cancer

[ISO-abbreviation] Int. J. Cancer

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / CA090440-08; United States / NCI NIH HHS / CA / P50 CA090440; United States / NCI NIH HHS / CA / R01 CA132844-01A2; United States / NCI NIH HHS / CA / P50 CA90440; United States / NCI NIH HHS / CA / CA132844-01A2; United States / NCI NIH HHS / CA / P50 CA090440-08; United States / NCI NIH HHS / CA / R01 CA132844

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Histone Deacetylase Inhibitors; 0 / Histones; 0 / Hydroxamic Acids; 0 / Neoplasm Proteins; 0 / Tubulin; 58IFB293JI / vorinostat; BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel

[Other-IDs] NLM/ NIHMS137936; NLM/ PMC2795066

   

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[Title] Non-mucinous and mucinous subtypes of adenocarcinoma with bronchioloalveolar carcinoma features differ by biomarker expression and in the response to gefitinib.

There is no optimal established therapy for treating advanced or recurrent adenocarcinoma with bronchioloalveolar carcinoma features (ADC-BAC), and it remains unclear whether chemotherapy achieves therapeutic results comparable to those seen in the more common non-small lung carcinoma subtypes.

In order to improve the decisions made during the treatment of advanced ADC-BAC, we attempted to better characterize the mucinous and non-mucinous ADC-BAC subtypes.

Fifty pathological samples were obtained from 62 patients included in a multicenter prospective phase II trial (IFCT0401) conducted to evaluate gefitinib as a first-line therapy for non-resectable ADC-BAC.

We demonstrated that demographic data, clinical characteristics and stage at presentation (extrathoracic versus lung metastasis, as well as TNM staging) did not distinguish between the two subtypes.

In contrast, three biological markers (PAS staining, TTF-1 expression and EGFR genomic gain combined with mutation analysis) enabled us to independently segregate all but 2 of the 50 patients into the mucinous and non-mucinous ADC-BAC subtypes.

[MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Adenocarcinoma, Mucinous / diagnosis. DNA-Binding Proteins / metabolism. Lung Neoplasms / diagnosis. Receptor, Epidermal Growth Factor / genetics

[MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. DNA Mutational Analysis. Disease Progression. Drug Resistance, Neoplasm. Female. Humans. Male. Middle Aged. Quinazolines / therapeutic use

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[Copyright] Copyright 2009 Elsevier Ireland Ltd. All rights reserved.

(PMID = 19581016.001).

[ISSN] 1872-8332

[Journal-full-title] Lung cancer (Amsterdam, Netherlands)

[ISO-abbreviation] Lung Cancer

[Language] eng

[Publication-type] Clinical Trial, Phase II; Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't

[Publication-country] Ireland

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Quinazolines; 0 / TTF1 protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; S65743JHBS / gefitinib

   

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[Title] Primary hyperparathyroidism and metastatic carcinoma within parathyroid gland.

[MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / secondary. Hyperparathyroidism, Primary / complications. Lung Neoplasms. Parathyroid Neoplasms / secondary

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(PMID = 17761743.001).

[ISSN] 0021-9746

[Journal-full-title] Journal of clinical pathology

[ISO-abbreviation] J. Clin. Pathol.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] England

[Other-IDs] NLM/ PMC1972420

   

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[Title] In vitro toxicity of silica nanoparticles in human lung cancer cells.

The cytotoxicity of 15-nm and 46-nm silica nanoparticles was investigated by using crystalline silica (Min-U-Sil 5) as a positive control in cultured human bronchoalveolar carcinoma-derived cells.

Exposure to 15-nm or 46-nm SiO(2) nanoparticles for 48 h at dosage levels between 10 and 100 microg/ml decreased cell viability in a dose-dependent manner.

Cell viability decreased significantly as a function of both nanoparticle dosage (10-100 microg/ml) and exposure time (24 h, 48 h, and 72 h).

In summary, exposure to SiO(2) nanoparticles results in a dose-dependent cytotoxicity in cultural human bronchoalveolar carcinoma-derived cells that is closely correlated to increased oxidative stress.

[MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / drug therapy. Lung Neoplasms / drug therapy. Nanoparticles / toxicity. Silicon Dioxide / toxicity

[MeSH-minor] Cell Line, Tumor. Cell Survival / drug effects. Chromatography, High Pressure Liquid. Dose-Response Relationship, Drug. Glutathione / metabolism. Humans. L-Lactate Dehydrogenase / metabolism. Lipid Peroxidation / drug effects. Malondialdehyde / metabolism. Oxidative Stress / drug effects. Particle Size. Reactive Oxygen Species / metabolism

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[CommentIn] Toxicol Appl Pharmacol. 2007 Apr 15;220(2):225; author reply 226 [17350663.001]

(PMID = 17112558.001).

[ISSN] 0041-008X

[Journal-full-title] Toxicology and applied pharmacology

[ISO-abbreviation] Toxicol. Appl. Pharmacol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Reactive Oxygen Species; 4Y8F71G49Q / Malondialdehyde; 7631-86-9 / Silicon Dioxide; EC 1.1.1.27 / L-Lactate Dehydrogenase; GAN16C9B8O / Glutathione

   

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[Title] Sequence analysis of bacterial artificial chromosome clones from the apospory-specific genomic region of Pennisetum and Cenchrus.

Thirty-two ASGR bacterial artificial chromosomes (BACs) isolated from both species and one ASGR-recombining BAC from P. squamulatum, which together cover approximately 2.7 Mb of DNA, were used to investigate the genomic structure of this region.

Phrap assembly of 4,521 high-quality reads generated 1,341 contiguous sequences (contigs; 730 from the ASGR and 30 from the ASGR-recombining BAC in P. squamulatum, plus 580 from the C. ciliaris ASGR).

These putative coding regions were further analyzed in silico with reference to the rice (Oryza sativa) and sorghum (Sorghum bicolor) genomes using the resources at Gramene (www.gramene.org) and Phytozome (www.phytozome.net) and by hybridization against sorghum BAC filters.

[MeSH-minor] Arabidopsis Proteins / genetics. Chromosomes, Artificial, Bacterial. Cloning, Molecular. DNA Transposable Elements. Gene Duplication. Genome, Plant. Molecular Sequence Data. Oryza / genetics. Sequence Analysis, DNA. Sorghum / genetics. Synteny. Transcription Factors / genetics

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(PMID = 18508959.001).

[ISSN] 0032-0889

[Journal-full-title] Plant physiology

[ISO-abbreviation] Plant Physiol.

[Language] eng

[Databank-accession-numbers] GENBANK/ ED544199/ ED548719/ EU559277/ EU559280

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

[Publication-country] United States

[Chemical-registry-number] 0 / Arabidopsis Proteins; 0 / BABY BOOM protein, Arabidopsis; 0 / DNA Transposable Elements; 0 / Transcription Factors

[Other-IDs] NLM/ PMC2442526

   

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[Title] Construction and application of a full-coverage, high-resolution, human chromosome 8q genomic microarray for comparative genomic hybridization.

METHODS: A minimal tiling path contig of 702 8q-specific bacterial artificial chromosome (BAC) clones was generated with a novel computational tool (BAC Contig Assembler).

BAC clones were amplified by degenerative oligonucleotide primer (DOP) polymerase chain reaction and subsequently printed onto glass slides.

For validation of the array DNA samples of gastroesophageal and prostate cancer cell lines, and chronic myeloid leukemia specimens were used, which were previously characterized by multicolor fluorescence in situ hybridization and conventional CGH.

The 8q array was further tested with paraffin-embedded prostate cancer specimens.

In comparison with conventional CGH, the resolution of the detected changes was much improved, which was demonstrated by an amplicon of 0.7 Mb and a deletion of 0.6 Mb, both spanned by only six BAC clones.

[MeSH-minor] Adenocarcinoma / genetics. Cardia. Chromosome Aberrations. Fixatives. Formaldehyde. Humans. In Situ Hybridization, Fluorescence. Male. Nucleic Acid Hybridization. Oligonucleotide Array Sequence Analysis. Prostatic Neoplasms / genetics. Stomach Neoplasms / genetics. Tumor Cells, Cultured

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(PMID = 15619731.001).

[ISSN] 1552-4922

[Journal-full-title] Cytometry. Part A : the journal of the International Society for Analytical Cytology

[ISO-abbreviation] Cytometry A

[Language] eng

[Grant] United States / NCI NIH HHS / CA / CA89520

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

[Publication-country] United States

[Chemical-registry-number] 0 / Fixatives; 1HG84L3525 / Formaldehyde

   

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The biological activated carbon (BAC) filter could effectively reduce CHCl3FP and CHCl2BrFP, but increase CHClBr2FP.

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(PMID = 17672213.001).

[ISSN] 0895-3988

[Journal-full-title] Biomedical and environmental sciences : BES

[ISO-abbreviation] Biomed. Environ. Sci.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Bromates; 0 / Trihalomethanes; 4R7X1O2820 / Chlorine; 66H7ZZK23N / Ozone

   

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[Title] Highly B lymphocyte-specific tamoxifen inducible transgene expression of CreER T2 by using the LC-1 locus BAC vector.

The generation of cell type specific inducible Cre transgenic mice is the most challenging and limiting part in the development of spatio-temporally controlled knockout mouse models.

Here we report the generation and characterization of a B lymphocyte-specific tamoxifen-inducible Cre transgenic mouse strain, LC-1-hCD19-CreER(T2).

[MeSH-major] B-Lymphocytes / metabolism. Chromosomes, Artificial, Bacterial. Gene Expression Regulation / drug effects. Integrases / genetics. Tamoxifen / pharmacology. Transgenes

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[Copyright] (c) 2009 Wiley-Liss, Inc.

(PMID = 19621440.001).

[ISSN] 1526-968X

[Journal-full-title] Genesis (New York, N.Y. : 2000)

[ISO-abbreviation] Genesis

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Antigens, CD19; 0 / DNA Primers; 094ZI81Y45 / Tamoxifen; EC 2.7.7.- / Cre recombinase; EC 2.7.7.- / Integrases

   

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Micronodular pneumocyte hyperplasia (MNPH) is often associated with tuberous sclerosis complex and/or lymphangioleiomyomatosis.

We present the case of a 45-year-old woman with MNPH without evidence of either.

A preoperative high-resolution chest computed topographic scan demonstrated a ground-glass opacity 8 mm in diameter that revealed the possibility of atypical adenomatous hyperplasia (AAH) or bronchioloalveolar carcinoma (BAC).

Therefore an S3 segmentectomy of the right lung was performed, and the specimens revealed the characteristic histological and immunohistological features of MNPH.

Solitary MNPH is extremely rare and requires to be distinguished from AAH or BAC on a computed tomographic scan; therefore surgical resection may be required to definitely rule out malignancy.

[MeSH-major] Pneumocytes / pathology. Solitary Pulmonary Nodule / diagnosis

[MeSH-minor] Biopsy. Diagnosis, Differential. Female. Humans. Hyperplasia. Immunohistochemistry. Middle Aged. Predictive Value of Tests. Tomography, X-Ray Computed

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(PMID = 20190710.001).

[ISSN] 2186-1005

[Journal-full-title] Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia

[ISO-abbreviation] Ann Thorac Cardiovasc Surg

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Japan

   

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[Title] Precursor lesions of adenocarcinoma lung--two case reports.

Although precursor lesions of bronchogenic squamous cell carcinoma are well documented, the preinvasive lesions of pulmonary adenocarcinoma are seen very rarely.

It has been hypothesized that there is a stepwise progression of alveolar epithelial hyperplasia to atypical alveolar hyperplasia and subsequently to malignancy in the pathogenesis of peripheral adenocarcinoma of the lung.

In the present paper we would like to share our experience of two cases of pulmonary adenocarcinoma with their precursor lesions in the form of atypical alveolar hyperplasia.

[MeSH-major] Adenocarcinoma / pathology. Lung Diseases, Interstitial / pathology. Lung Neoplasms / pathology. Precancerous Conditions / pathology. Pulmonary Alveoli / pathology

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(PMID = 16761769.001).

[ISSN] 0377-4929

[Journal-full-title] Indian journal of pathology & microbiology

[ISO-abbreviation] Indian J Pathol Microbiol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] India

   

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The development of a universal soybean (Glycine max [L.

We used genetically anchored BAC clones both to identify individual chromosomes in metaphase spreads and to complete a FISH-based karyotyping cocktail that permitted simultaneous identification of all 20 chromosome pairs.

These studies led to the identification and characterization of a reciprocal chromosome translocation between chromosomes 11 and 13 in two accessions of wild soybean.

[MeSH-minor] Base Sequence. Chromosomes, Artificial, Bacterial. DNA, Plant. Molecular Sequence Data. Nucleic Acid Hybridization

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(PMID = 20421607.001).

[ISSN] 1943-2631

[Journal-full-title] Genetics

[ISO-abbreviation] Genetics

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

[Publication-country] United States

[Chemical-registry-number] 0 / DNA, Plant

[Other-IDs] NLM/ PMC2907198

   

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The system uses sufficient VUV radiation (16J cm(-2)) to significantly enhance the production of biologically degradable moieties prior to treatment with biologically activated carbon (BAC).

The VUV-BAC process decreased the overall dissolved organic carbon (DOC) concentration of a natural water sample by 54% and 44% for the virgin carbon and previously used BAC, respectively.

Furthermore, VUV-BAC treatment decreased the trihalomethane (THM) formation potential (THMFP) by 60-70% and the haloacetic acid (HAA) formation potential (HAAFP) by 74%.

The BAC systems effectively removed the hydrogen peroxide residual produced by VUV irradiation.

Although nitrite formation can result from VUV treatment of natural organic matter (NOM), none was detected before or after BAC treatment.

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(PMID = 18502470.001).

[ISSN] 0043-1354

[Journal-full-title] Water research

[ISO-abbreviation] Water Res.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Biological Products; 0 / Nitrates; 0 / Organic Chemicals; 7440-44-0 / Carbon; BBX060AN9V / Hydrogen Peroxide

   

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[Title] Validation study of the proposed IASLC staging revisions of the T4 and M non-small cell lung cancer descriptors using data from 23,583 patients in the California Cancer Registry.

BACKGROUND: We performed a validation study of the proposed International Association for the Study of Lung Cancer (IASLC) tumor, node, metastasis (TNM) and stage grouping revisions on advanced nonbronchioloalveolar carcinoma (non-BAC) non-small cell lung cancer (NSCLC).

METHODS: Twenty-three thousand five hundred eighty-three patients from the California Cancer Registry between 1999 and 2003 with histologically confirmed non-BAC NSCLC and complete TNM staging were identified and reclassified according to the IASLC proposed TNM revisions and new stage groupings.

Surveillance, Epidemiology, and End Results extent of disease codes were used to identify various T4 and M descriptors.

T4 due to additional nodules had significant survival advantage over other T4 and M descriptors among non-BAC NSCLC and individual histology and warrants down-staging to T3.

CONCLUSIONS: IASLC has greatly improved the T4 and M descriptors allowing better prognostication of advanced non-BAC NSCLC.

[MeSH-major] Carcinoma, Non-Small-Cell Lung / secondary. Heart Neoplasms / secondary. Lung Neoplasms / pathology. Neoplasm Staging / methods. Pleural Neoplasms / secondary. Registries / statistics & numerical data

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(PMID = 18317063.001).

[ISSN] 1556-1380

[Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

[ISO-abbreviation] J Thorac Oncol

[Language] eng

[Grant] United States / NCCDPHP CDC HHS / DP / 1U58DP00807-01; United States / NCI NIH HHS / PC / N01-PC-35136; United States / NCI NIH HHS / PC / N01-PC-35139; United States / NCI NIH HHS / PC / N01-PC-54404

[Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Validation Studies

[Publication-country] United States

   

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In incubations with ruminal microbial fractions (bacterial fraction (BAC), protozoal fraction (PRO)), LA metabolism was very similar in strained ruminal fluid (SRF) and in the BAC, while the PRO had LA-metabolising activity an order of magnitude lower.

The absence of an alternative route of VA/CLA formation via desaturation of stearate was confirmed by incubations of SRF, BAC or PRO with [14C]stearate.

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(PMID = 17010229.001).

[ISSN] 0007-1145

[Journal-full-title] The British journal of nutrition

[ISO-abbreviation] Br. J. Nutr.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Linoleic Acids, Conjugated; 0 / Oleic Acids; 0 / Stearic Acids; 143-25-9 / 11-octadecenoic acid; 4ELV7Z65AP / stearic acid; 9KJL21T0QJ / Linoleic Acid

   

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[Title] Tgf-beta signaling pathway in lung adenocarcinoma invasion.

The histologic distinction between bronchioloalveolar carcinoma and other adenocarcinomas is tissue invasion.

The clinical importance of lung adenocarcinoma invasion is supported by several recent studies indicating that the risk of death in nonmucinous bronchioloalveolar carcinoma is significantly lower than that of pure invasive tumors and in tumors with greater than 0.5 cm of fibrosis or linear invasion.

Subsequent studies showed that the CC chemokine regulated on activation, normal T cell expressed, and presumably secreted was up-regulated in invasive tumors and was required for invasion in cells with repressed levels of the transforming growth factor-beta type II receptor.

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(PMID = 20101143.001).

[ISSN] 1556-1380

[Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

[ISO-abbreviation] J Thorac Oncol

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / CA120174-04; United States / NCI NIH HHS / CA / R01 CA120174; United States / NCI NIH HHS / CA / R01 CA120174-04

[Publication-type] Journal Article; Review

[Publication-country] United States

[Chemical-registry-number] 0 / Chemokine CCL5; 0 / Transforming Growth Factor beta

[Number-of-references] 81

[Other-IDs] NLM/ NIHMS251531; NLM/ PMC2992959

   

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[Title] Cloning and expression of manganese superoxide dismutase of the silkworm, Bombyx mori by Bac-to-Bac/BmNPV Baculovirus expression system.

In this paper, we used the total fat body RNA of silkworm, Bombyx mori L. to clone and sequence a 648-bp Mn-SOD cDNA fragment through RT-PCR.

Furthermore, a newly established Bac-to-Bac/BmNPV Baculovirus expression system was used to overexpress the recombinant Mn-SOD enzyme in silkworm larvae.

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(PMID = 16804693.001).

[ISSN] 0175-7598

[Journal-full-title] Applied microbiology and biotechnology

[ISO-abbreviation] Appl. Microbiol. Biotechnol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Germany

[Chemical-registry-number] 0 / DNA, Complementary; 63231-63-0 / RNA; EC 1.15.1.1 / Superoxide Dismutase

   

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The authors compare the benzalconium chloride (BAC) concentrations in individual drug used for glaucoma treating.

The daily dose of BAC was calculated according to the drop's size and BAC concentration.

The daily dose of BAC differs depending on the selected therapy markedly--doses in the range from 0 to 10 micrograms were found.

The BAC concentration is one of important factors affecting the patient's compliance in the treatment of the primary open angle glaucoma.

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(PMID = 16895060.001).

[ISSN] 1211-9059

[Journal-full-title] Ceská a slovenská oftalmologie : casopis Ceské oftalmologické spolecnosti a Slovenské oftalmologické spolecnosti

[ISO-abbreviation] Cesk Slov Oftalmol

[Language] cze

[Publication-type] English Abstract; Journal Article

[Publication-country] Czech Republic

[Chemical-registry-number] 0 / Benzalkonium Compounds; 0 / Ophthalmic Solutions; 0 / Preservatives, Pharmaceutical

   

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[Title] Development of a novel ozone- and photo-stable HyPer5 red fluorescent dye for array CGH and microarray gene expression analysis with consistent performance irrespective of environmental conditions.

In high resolution array CGH experiments, HyPer5 is demonstrated to detect chromosomal aberrations at loci 2p21-16.3 and 15q26.3-26.2 from three patient sample using bacterial artificial chromosome (BAC) arrays.

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[Cites] Biotechniques. 2002 Sep;33(3):620-8, 630 [12238772.001]

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(PMID = 19014508.001).

[ISSN] 1472-6750

[Journal-full-title] BMC biotechnology

[ISO-abbreviation] BMC Biotechnol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Chemical-registry-number] 0 / Carbocyanines; 0 / DNA, Complementary; 0 / Fluorescent Dyes; 66H7ZZK23N / Ozone

[Other-IDs] NLM/ PMC2613886

   

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[Title] Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.

The N-terminal 17 amino acids of huntingtin (NT17) can be phosphorylated on serines 13 and 16; however, the significance of these modifications in Huntington's disease pathogenesis remains unknown.

In this study, we developed BAC transgenic mice expressing full-length mutant huntingtin (fl-mhtt) with serines 13 and 16 mutated to either aspartate (phosphomimetic or SD) or alanine (phosphoresistant or SA).

However, fl-mhtt-induced disease pathogenesis, including motor and psychiatric-like behavioral deficits, mhtt aggregation, and selective neurodegeneration are abolished in SD but preserved in SA mice.

Together, our findings demonstrate that serines 13 and 16 are critical determinants of fl-mhtt-induced disease pathogenesis in vivo, supporting the targeting of huntingtin NT17 domain and its modifications in HD therapy.

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[Copyright] 2009 Elsevier Inc. All rights reserved.

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(PMID = 20064390.001).

[ISSN] 1097-4199

[Journal-full-title] Neuron

[ISO-abbreviation] Neuron

[Language] ENG

[Grant] United States / NINDS NIH HHS / NS / NS049501-04; United States / NINDS NIH HHS / NS / R01 NS049501; United States / NINDS NIH HHS / NS / NS049501-05; United States / NINDS NIH HHS / NS / 2R01NS45491; United States / NINDS NIH HHS / NS / R24 NS045491; United States / NINDS NIH HHS / NS / R01 NS049501-04; United States / NINDS NIH HHS / NS / R01 NS039074; United States / NIA NIH HHS / AG / R01AG019322; United States / NINDS NIH HHS / NS / R01NS049501; United States / NINDS NIH HHS / NS / NS049501-03; United States / NINDS NIH HHS / NS / R01 NS049501-01; United States / NINDS NIH HHS / NS / NS045283; United States / NINDS NIH HHS / NS / R01 NS049501-05; United States / NINDS NIH HHS / NS / 3R01NS049501-05S1; United States / NINDS NIH HHS / NS / 2R01NS39074; United States / NINDS NIH HHS / NS / NS049501-02; United States / NINDS NIH HHS / NS / R01 NS049501-03; United States / NINDS NIH HHS / NS / R01 NS045283; United States / NINDS NIH HHS / NS / R01 NS052789; United States / NIA NIH HHS / AG / R01 AG019322; United States / NIA NIH HHS / AG / P01 AG022074; United States / NINDS NIH HHS / NS / R01 NS049501-02; United States / NINDS NIH HHS / NS / NS049501-05S1; United States / NINDS NIH HHS / NS / NS049501-01; United States / NINDS NIH HHS / NS / NS52789; United States / NINDS NIH HHS / NS / R01 NS049501-05S1; United States / NIA NIH HHS / AG / 2P01AG022074

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Amyloid; 0 / HTT protein, human; 0 / Nerve Tissue Proteins; 0 / Nuclear Proteins; 30KYC7MIAI / Aspartic Acid; 452VLY9402 / Serine; OF5P57N2ZX / Alanine

[Other-IDs] NLM/ NIHMS161315; NLM/ PMC2807408

   

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A complete genomic nucleotide sequence for porcine pTalpha gene was obtained from a BAC clone, which revealed a novel exon 2 missing in human and murine counterparts.

Using thymocyte RNA and RT-PCR, three types of porcine pTalpha-chain cDNA sequences, pTalpha1, pTalpha2 and pTalpha3, were obtained.

Using RT-PCR, pTalpha3 appeared expressed predominantly in the thymocyte RNA.

[MeSH-major] Alternative Splicing. Genome. Membrane Glycoproteins / genetics. Receptors, Antigen, T-Cell, alpha-beta / genetics. Swine / genetics

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(PMID = 16712934.001).

[ISSN] 0161-5890

[Journal-full-title] Molecular immunology

[ISO-abbreviation] Mol. Immunol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Chemical-registry-number] 0 / Membrane Glycoproteins; 0 / Receptors, Antigen, T-Cell, alpha-beta; 0 / pre-T cell receptor alpha

   

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In order to understand their potential significance and to facilitate interpretation of array-CGH findings in constitutional disorders and cancers, we studied 27 normal individuals (9 Caucasian; 9 African American; 9 Hispanic) using commercially available 1 Mb resolution BAC array (Spectral Genomics).

A selection of CNVs was further analyzed by FISH and real-time quantitative PCR (RT-qPCR).

FISH analysis of 6 CNVs (4 previously reported and 2 novel CNVs) in normal subjects resulted in the confirmation of copy number changes for 1 of 2 novel CNVs and 2 of 4 known CNvs. Three CNVs tested by FISH were further validated by RT-qPCR and comparable data were obtained.

This included the lack of copy number change by both RT-qPCR and FISH for clone RP11-100C24, one of the most common known copy number variants, as well as confirmation of deletions for clones RP11-89M16 and RP5-1011O17.

Further study of a small selection of CNVs indicated concordant and discordant array vs. FISH/RT-qPCR results.

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(PMID = 17565693.001).

[ISSN] 1471-2164

[Journal-full-title] BMC genomics

[ISO-abbreviation] BMC Genomics

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Other-IDs] NLM/ PMC1920519

   

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Available BAC and BAC-end sequences and their naming and mapping information, all obtained from SangerInstitute FTP site, served as a rough assembly of a reference genome.

[MeSH-minor] Animals. Chromosomes, Artificial, Bacterial. Cluster Analysis. Genetic Markers. Sequence Alignment. Sequence Analysis, DNA / methods

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(PMID = 19126189.001).

[ISSN] 1471-2164

[Journal-full-title] BMC genomics

[ISO-abbreviation] BMC Genomics

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Genetic Markers

[Other-IDs] NLM/ PMC2637895

   

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LS-GR shows high recombination efficiency for medium copy number vector and single copy number BAC vector modifications.

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(PMID = 20618864.001).

[ISSN] 1574-6968

[Journal-full-title] FEMS microbiology letters

[ISO-abbreviation] FEMS Microbiol. Lett.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Recombinases; 0 / Viral Proteins

   

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We have developed a clinically validated, targeted BAC clone array as a platform for comparative genomic hybridization (aCGH) to enable detection of a wide range of pathologic copy number changes in DNA.

This enhanced ability of aCGH to detect mosaicism missed by routine chromosome analysis may be due to some combination of testing multiple cell lineages and/or failure of cytogenetically abnormal T lymphocytes to respond to mitogens.

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[Copyright] (c) 2007 Wiley-Liss, Inc.

(PMID = 17607705.001).

[ISSN] 1552-4833

[Journal-full-title] American journal of medical genetics. Part A

[ISO-abbreviation] Am. J. Med. Genet. A

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

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Using fluorescence in situ hybridization and BAC clones, the supernumerary marker chromosome was found to be a highly deleted chromosome 7 with breakpoints within the pericentric euchromatin (partial trisomy 7).

Considering that the SMC(7) contributed very little, if any, to the phenotype of this boy, we propose that UPD7 studies should be carried out in children with pre- and postnatal growth retardation of unknown cause even in the absence of a SMC.

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(PMID = 16317300.001).

[ISSN] 0962-8827

[Journal-full-title] Clinical dysmorphology

[ISO-abbreviation] Clin. Dysmorphol.

[Language] eng

[Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Euchromatin

   

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Benzalkonium chloride (BAC) exerts toxic effects on microorganisms.

Various BAC-containing preparations used by people may induce a number of adverse effects on the human body.

Bearing in mind that BAC is widely used in different branches of the national economy, its toxic effect may cause a health problem of significant importance to humans.

The authors describe BAC toxic effects exerted on humans and laboratory animals as well as relevant hazards resulting from the use of BAC-contained preparations.

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(PMID = 17926503.001).

[ISSN] 0465-5893

[Journal-full-title] Medycyna pracy

[ISO-abbreviation] Med Pr

[Language] pol

[Publication-type] English Abstract; Journal Article; Review

[Publication-country] Poland

[Chemical-registry-number] 0 / Benzalkonium Compounds; 0 / Preservatives, Pharmaceutical

[Number-of-references] 25

   

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[Title] Mucinous adenocarcinoma of the lung in association with congenital pulmonary airway malformation.

Congenital pulmonary airway malformation (CPAM) is a rare developmental abnormality of the lung that has been associated with the presence of rhabdomyosarcoma, pleuropulmonary blastoma, and most commonly bronchioalveolar carcinoma (BAC) of the lung.

Here, we report the case of an 8-year-old patient who developed KRAS mutation positive stage IV mucinous adenocarcinoma of the lung in association with CPAM.

This case reflects the previously recognized progression of CPAM to malignancy and suggests that BAC arising in CPAM may take a more aggressive course than previously recognized.

[MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Cystic Adenomatoid Malformation of Lung, Congenital / diagnosis. Lung Neoplasms / diagnosis. Precancerous Conditions

[MeSH-minor] Bronchoscopy. Child. Diagnosis, Differential. Female. Humans. Pneumonectomy / methods. Tomography, X-Ray Computed

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[Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.

(PMID = 21034957.001).

[ISSN] 1531-5037

[Journal-full-title] Journal of pediatric surgery

[ISO-abbreviation] J. Pediatr. Surg.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

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Both class switch recombination (CSR) and somatic hypermutation (SHM) require transcription and the trans-acting factor activation-induced cytidine deaminase (AID), and must be up-regulated during antigen-dependent differentiation of B lymphocytes.

To test the role of the heavy chain 3' enhancers in both CSR and SHM, we used a BAC transgene of the entire heavy chain constant region locus.

Using Cre-loxP recombination to delete a 28-kb region that contains the four known 3' heavy chain enhancers, we isolated lines of BAC transgenic mice with an intact heavy chain locus and paired lines in the same chromosomal insertion site lacking the 3' enhancers.

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(PMID = 19887393.001).

[ISSN] 1540-9538

[Journal-full-title] The Journal of experimental medicine

[ISO-abbreviation] J. Exp. Med.

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / P30 CA046592; United States / NIAID NIH HHS / AI / AI076057; United States / NCI NIH HHS / CA / CA46592; United States / NCI NIH HHS / CA / R01 CA098495; United States / NIAID NIH HHS / AI / R01 AI076057; United States / NCI NIH HHS / CA / CA098495

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / 3' Untranslated Regions; 0 / Immunoglobulin Heavy Chains; EC 2.7.7.- / Cre recombinase; EC 2.7.7.- / Integrases; EC 3.5.4.5 / Cytidine Deaminase

[Other-IDs] NLM/ PMC2806627

   

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Herein we describe the development of a versatile Escherichia coli-Streptomyces shuttle Bacterial Artificial Chromosomal (BAC) conjugation vector, pSBAC, to facilitate the cloning, genetic manipulation, and heterologous expression of actinomycetes secondary metabolite biosynthetic gene clusters.

The success of heterologous expression of such a giant gene cluster demonstrates the versatility of BAC cloning technology and paves the road for future exploration of expression of the meridamycin biosynthetic pathway in various hosts, including strains that have been optimized for polyketide production.

[MeSH-major] Escherichia coli / genetics. Genes, Bacterial / genetics. Macrolides / chemical synthesis. Macrolides / metabolism. Polyketide Synthases / metabolism. Streptomyces / genetics

[MeSH-minor] Chromosomes, Artificial. Chromosomes, Artificial, Bacterial / metabolism. Cloning, Molecular. Genetic Vectors / chemical synthesis. Genetic Vectors / genetics. Molecular Structure

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(PMID = 19191550.001).

[ISSN] 1520-6025

[Journal-full-title] Journal of natural products

[ISO-abbreviation] J. Nat. Prod.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / 3-normeridamycin; 0 / Macrolides; 0 / meridamycin; 79956-01-7 / Polyketide Synthases

   

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Disc biacuplasty (D-BAC) is a novel procedure that uses two water-cooled radiofrequency electrodes in a bipolar configuration to heat a large volume of the posterior annulus fibrosus.

METHODS: Seven porcine lumbar discs were treated with D-BAC to assess acute effects on the treated tissue in a "worst-case"in vivo model.

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(PMID = 18254764.001).

[ISSN] 1526-2375

[Journal-full-title] Pain medicine (Malden, Mass.)

[ISO-abbreviation] Pain Med

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

   

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Primer pairs were designed for 15 loci around each candidate gene, in a region of about 20 megabases and were used to screen a bovine Bacterial Artificial Chromosome (BAC) library.

Eighteen microsatellites were found in the identified BAC clones, 11 on BTA24 and seven on BTA16.

[MeSH-major] Arthrogryposis / veterinary. Ataxia / veterinary. Cattle Diseases / genetics. Cattle Diseases / pathology. Genetic Predisposition to Disease / genetics

[MeSH-minor] Animals. Cattle. Chromosomes, Artificial, Bacterial. DNA Primers. Humans. Mice. Microsatellite Repeats / genetics. Radiation Hybrid Mapping / veterinary. Rats

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(PMID = 16130454.001).

[ISSN] 0931-2668

[Journal-full-title] Journal of animal breeding and genetics = Zeitschrift für Tierzüchtung und Züchtungsbiologie

[ISO-abbreviation] J. Anim. Breed. Genet.

[Language] eng

[Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Germany

[Chemical-registry-number] 0 / DNA Primers

   

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[Title] Unusual chemosensitivity of advanced bronchioalveolar carcinoma after gefitinib response and progression: a case report.

Bronchioalveolar carcinoma of the lung represents increasingly recognized clinical entity with relatively high probability of response to epidermal growth factor receptor tyrosine kinase inhibitors.

[MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / drug therapy. Antineoplastic Agents / therapeutic use. Lung Neoplasms / drug therapy. Protein Kinase Inhibitors / therapeutic use. Quinazolines / therapeutic use. Receptor, Epidermal Growth Factor / genetics

[MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Disease Progression. Female. Humans

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(PMID = 17410018.001).

[ISSN] 1556-1380

[Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

[ISO-abbreviation] J Thorac Oncol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Protein Kinase Inhibitors; 0 / Quinazolines; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; S65743JHBS / gefitinib

   

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In the present study, a bacterial artificial chromosome (BAC) clone, mps01, was screened from the BAC library constructed from Monascus pilosus BCRC38072 genomic DNA.

[MeSH-minor] Amino Acid Sequence. Chromosomes, Artificial, Bacterial. Molecular Sequence Data. Phylogeny. Polyketide Synthases / genetics. Polyketide Synthases / metabolism

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(PMID = 18578535.001).

[ISSN] 1520-5118

[Journal-full-title] Journal of agricultural and food chemistry

[ISO-abbreviation] J. Agric. Food Chem.

[Language] eng

[Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 79956-01-7 / Polyketide Synthases; 9LHU78OQFD / Lovastatin

   

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[Title] Rapid identification of non-essential genes for in vitro replication of Marek's disease virus by random transposon mutagenesis.

Marek's disease virus (MDV) is a highly oncogenic alphaherpesvirus that induces rapid-onset T-cell lymphomas in poultry.

The construction of an infectious bacterial artificial chromosome (BAC) clone of the highly oncogenic RB-1B strain of MDV has been described previously.

Virus reconstituted from the BAC clone induced rapid-onset lymphomas in chickens very similar to the wildtype viruses.

In this paper, the construction of a high-density random transposon-insertion mutant library of the RB-1B BAC clone using a high throughput in vitro transposon mutagenesis technique is described.

[MeSH-minor] Chromosomes, Artificial, Bacterial. Open Reading Frames

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(PMID = 16650486.001).

[ISSN] 0166-0934

[Journal-full-title] Journal of virological methods

[ISO-abbreviation] J. Virol. Methods

[Language] eng

[Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / / BBS/B/10544

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Netherlands

[Chemical-registry-number] 0 / DNA Transposable Elements

   

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Magnetite iron nanoparticles have been widely used as contrast agents and in thermal therapy for cancer.

When mice were treated with iron oxide nanoparticles (250 microg/kg, 500 microg/kg, and 1mg/kg) by a single intratracheal instillation, the level of intracellular reduced glutathione (GSH) was decreased in the cells of bronchoalveolar lavage (BAL) fluid.

The arrest of cell cycles in G1 phase was observed, but S-phase was significantly decreased.

Formation of microgranuloma, which is one of the indicators for chronic inflammatory response, was observed in the alveolar space.

In addition, distribution of B cell and CD8+ T cell in blood lymphocytes was increased at day 28.

[MeSH-major] Ferric Compounds / toxicity. Inflammation Mediators / toxicity. Lung / drug effects. Lung / metabolism. Nanoparticles / toxicity. Trachea / drug effects

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[Copyright] (c) 2010 Elsevier Ireland Ltd. All rights reserved.

(PMID = 20540983.001).

[ISSN] 1879-3185

[Journal-full-title] Toxicology

[ISO-abbreviation] Toxicology

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] Ireland

[Chemical-registry-number] 0 / Ferric Compounds; 0 / Inflammation Mediators; 1K09F3G675 / ferric oxide

   

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BACKGROUND AND AIM OF THE WORK: Reduced expression and activity of the peroxisome proliferator-activated receptor gamma (PPARG) have been measured in cells of bronchoalveolar lavage fluid in sarcoidosis patients.

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(PMID = 19070258.001).

[ISSN] 1124-0490

[Journal-full-title] Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG

[ISO-abbreviation] Sarcoidosis Vasc Diffuse Lung Dis

[Language] ENG

[Publication-type] Comparative Study; Journal Article

[Publication-country] Italy

[Chemical-registry-number] 0 / Heat-Shock Proteins; 0 / PPAR gamma; 0 / PPARGC1A protein, human; 0 / Transcription Factors; 9007-49-2 / DNA

   

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[Title] Lung cancer in octogenarians: factors affecting morbidity and mortality after pulmonary resection.

BACKGROUND: Predictors of morbidity and mortality after pulmonary resection for lung cancer in patients 80 years of age or older are unknown.

METHODS: The medical records of all patients 80 years of age or older who had pulmonary resection for lung cancer from January 1985 through September 2004 were reviewed.

The cancer was squamous cell carcinoma in 143 patients (37.7%), adenocarcinoma in 166 (43.8%), bronchoalveolar cell carcinoma in 47 (12.4%), and other in 23 (6.1%).

CONCLUSIONS: Pulmonary resection for lung cancer in octogenarians is feasible.

[MeSH-major] Adenocarcinoma / surgery. Carcinoma, Squamous Cell / surgery. Lung Neoplasms / surgery. Pneumonectomy / statistics & numerical data

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(PMID = 16996903.001).

[ISSN] 1552-6259

[Journal-full-title] The Annals of thoracic surgery

[ISO-abbreviation] Ann. Thorac. Surg.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Netherlands

   

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BACKGROUND: Eosinophil-epithelial cell interactions make a major contribution to asthmatic airway inflammation.

Neurotrophin levels are increased in bronchoalveolar lavage fluid during allergic asthma.

OBJECTIVE: We sought to investigate the role of neurotrophins as inflammatory mediators in eosinophil-epithelial cell interactions during the allergic immune response.

METHODS: Neurotrophin expression in the lung was investigated by means of immunohistochemistry and ELISA in a mouse model of chronic experimental asthma.

Coculture experiments were performed with airway epithelial cells and bronchoalveolar lavage fluid eosinophils.

RESULTS: Neurotrophin levels increased continuously during chronic allergic airway inflammation, and airway epithelial cells were the major source of NGF and BDNF within the inflamed lung.

Lung eosinophils expressed the BDNF and NGF receptors tropomyosin-related kinase (Trk) A and TrkB, and coculture with airway epithelial cells resulted in enhanced epithelial neurotrophin production, as well as in prolonged survival of eosinophils.

[MeSH-minor] Animals. Asthma / etiology. Asthma / pathology. Asthma / physiopathology. Base Sequence. Brain-Derived Neurotrophic Factor / biosynthesis. Cell Survival. Cytokines / pharmacology. Epithelial Cells / drug effects. Epithelial Cells / physiology. Female. Inflammation Mediators / metabolism. Mice. Mice, Inbred BALB C. Models, Biological. RNA, Messenger / genetics. RNA, Messenger / metabolism. Receptor, trkA / biosynthesis. Receptor, trkB / biosynthesis

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(PMID = 16630935.001).

[ISSN] 0091-6749

[Journal-full-title] The Journal of allergy and clinical immunology

[ISO-abbreviation] J. Allergy Clin. Immunol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Brain-Derived Neurotrophic Factor; 0 / Cytokines; 0 / Inflammation Mediators; 0 / Nerve Growth Factors; 0 / RNA, Messenger; EC 2.7.10.1 / Receptor, trkA; EC 2.7.10.1 / Receptor, trkB

   

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[Title] Deregulated expression of hnRNP A/B proteins in human non-small cell lung cancer: parallel assessment of protein and mRNA levels in paired tumour/non-tumour tissues.

The altered expression pattern of hnRNP A2/B1 and/or splicing variant B1 alone in human lung cancer and their potential to serve as molecular markers for early diagnosis remain issues of intense investigation.

The main objective of the present study was to use paired tumour/non-tumour biopsies from patients with non-small cell lung cancer (NSCLC) to investigate the expression profiles of hnRNP A1, A2/B1 and A3 in conjunction with ASF/SF2.

METHODS: We combined western blotting of tissue homogenates with immunohistochemical examination of fixed tissue sections and quantification of mRNA expression levels in tumour versus adjacent normal-looking areas of the lung in the same patient.

[MeSH-major] Carcinoma, Non-Small-Cell Lung / genetics. Carcinoma, Non-Small-Cell Lung / metabolism. Heterogeneous-Nuclear Ribonucleoprotein Group A-B / metabolism. Lung / metabolism. RNA, Messenger / genetics

[MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / metabolism. Adenocarcinoma / secondary. Adenocarcinoma, Bronchiolo-Alveolar / genetics. Adenocarcinoma, Bronchiolo-Alveolar / metabolism. Adenocarcinoma, Bronchiolo-Alveolar / secondary. Aged. Blotting, Western. Carcinoma, Large Cell / genetics. Carcinoma, Large Cell / metabolism. Carcinoma, Large Cell / secondary. Carcinoma, Squamous Cell / genetics. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / secondary. Female. Humans. Immunoenzyme Techniques. Lung Neoplasms / genetics. Lung Neoplasms / metabolism. Lung Neoplasms / pathology. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Nuclear Proteins / genetics. Nuclear Proteins / metabolism. RNA-Binding Proteins / genetics. RNA-Binding Proteins / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Serine-Arginine Splicing Factors. Survival Rate. Treatment Outcome

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(PMID = 20716340.001).

[ISSN] 1471-2407

[Journal-full-title] BMC cancer

[ISO-abbreviation] BMC Cancer

[Language] eng

[Publication-type] Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / HNRNPA3 protein, human; 0 / Heterogeneous-Nuclear Ribonucleoprotein Group A-B; 0 / Nuclear Proteins; 0 / RNA, Messenger; 0 / RNA-Binding Proteins; 0 / hnRNP A1; 170974-22-8 / Serine-Arginine Splicing Factors

[Other-IDs] NLM/ PMC2933625

   

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In order to improve the spatial resolution of Biosusceptometry of Alternate Current (BAC), we are suggesting the coupling of a Doppler ultrasonic transducer with the BAC system.

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(PMID = 19964487.001).

[ISSN] 1557-170X

[Journal-full-title] Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

[ISO-abbreviation] Conf Proc IEEE Eng Med Biol Soc

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

   

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[Title] Toll like receptor 2 mediates bleomycin-induced acute lung injury, inflammation and fibrosis in mice.

Anti-cancer drug bleomycin (BLM) can cause acute lung injury (ALI) which often results in pulmonary fibrosis due to a failure of resolving acute inflammatory response.

TLR2 inhibition attenuated BLM-induced increase of inflammatory cells in bronchoalveolar lavage fluid (BALF), and reversed the immunosuppressive microenvironment by enhancing TH1 response (P<0.05) and inhibiting TH2 (P<0.001), Treg (P<0.01) and TH17 (P<0.01) responses.

[MeSH-major] Acute Lung Injury / metabolism. Cytokines / secretion. Inflammation / metabolism. Pulmonary Fibrosis / metabolism. Toll-Like Receptor 2 / metabolism

[MeSH-minor] Animals. Bleomycin / toxicity. Bronchoalveolar Lavage Fluid. Cells, Cultured. Dendritic Cells / cytology. Dendritic Cells / metabolism. Interleukin-17 / secretion. Interleukin-23 / secretion. Interleukin-6 / secretion. Lung / metabolism. MAP Kinase Signaling System. Male. Mice. Mice, Inbred C57BL. T-Lymphocytes, Regulatory / drug effects. Th1 Cells / drug effects. Th2 Cells / drug effects

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(PMID = 21348427.001).

[ISSN] 0513-4870

[Journal-full-title] Yao xue xue bao = Acta pharmaceutica Sinica

[ISO-abbreviation] Yao Xue Xue Bao

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] China

[Chemical-registry-number] 0 / Cytokines; 0 / Interleukin-17; 0 / Interleukin-23; 0 / Interleukin-6; 0 / Tlr2 protein, mouse; 0 / Toll-Like Receptor 2; 11056-06-7 / Bleomycin

   

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The vitreous alcohol concentration (VAC) exceeded the blood alcohol concentration (BAC) in 209 cases (71%).

In casework where the VAC > BAC, linear regression analysis indicated an R2 value of 0.958 (n = 209) and a VAC approximately 16% higher than the BAC.

The VAC/BAC ratio was more variable at lower BACs (< 0.1 g/100 mL).

Although VAC/BAC ratios were more consistent at concentrations of 0.1 g/100 mL and above, the overall ratio ranged from 1.01 to 2.20.

Of the 81 cases where BAC > VAC, a total of 24 cases indicated no vitreous alcohol.

Unlike the VAC/BAC data set which consisted of 97% femoral blood, the source of blood in the BAC > VAC data set was slightly more variable.

Of the 81 cases where BAC > VAC the blood source consisted of femoral (n = 68), heart (n = 8), pleural cavity (n = 2), carotid (n = 1), jugular (n = 1), and chest blood (n = 1).

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(PMID = 16105262.001).

[ISSN] 0146-4760

[Journal-full-title] Journal of analytical toxicology

[ISO-abbreviation] J Anal Toxicol

[Language] eng

[Publication-type] Case Reports; Comparative Study; Journal Article

[Publication-country] United States

[Chemical-registry-number] 3K9958V90M / Ethanol

   

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[Title] [Identification of a cryptic 1p36.3 microdeletion in a patient with Prader-Willi-like syndrome features].

OBJECTIVE: To determine the karyotype of a patient with Prader-Willi-like syndrome features.

RESULTS: No abnormality was discovered by high resolution karyotype analysis and methylation-specific PCR studies.

The deleted region was shown within a 4.2 Mb in the distal 1p by 3 BAC FISH probes of 1p36 combined with real-time PCR technique.

Family pedigree investigation showed the chromosome abnormality was de novo.

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(PMID = 20931530.001).

[ISSN] 1003-9406

[Journal-full-title] Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

[ISO-abbreviation] Zhonghua Yi Xue Yi Chuan Xue Za Zhi

[Language] chi

[Publication-type] Case Reports; English Abstract; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] China