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1. Gonçalves R, Saad Junior R, Dorgan Neto V, Botter M: [A rare case of pneumothorax: metastatic adamantinoma]. J Bras Pneumol; 2008 Jun;34(6):425-9
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  • [Title] [A rare case of pneumothorax: metastatic adamantinoma].
  • [Transliterated title] Caso raro de pneumotórax: adamantinoma metastático.
  • Here, we describe two cases of lung metastasis of adamantinoma of long bones, a low-grade bone neoplasm that rarely metastasizes.
  • [MeSH-major] Adamantinoma / secondary. Bone Neoplasms / pathology. Lung Neoplasms / secondary. Pneumothorax / etiology

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  • (PMID = 18622511.001).
  • [ISSN] 1806-3756
  • [Journal-full-title] Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia
  • [ISO-abbreviation] J Bras Pneumol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Brazil
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2. Jain D, Jain VK, Vasishta RK, Ranjan P, Kumar Y: Adamantinoma: a clinicopathological review and update. Diagn Pathol; 2008;3:8

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  • [Title] Adamantinoma: a clinicopathological review and update.
  • Adamantinoma is a primary low-grade, malignant bone tumor that is predominantly located in the mid-portion of the tibia.
  • The initial symptoms of adamantinoma are often indolent and nonspecific and depend on location and extent of the disease.
  • Histologically, classic adamantinoma is a biphasic tumor characterized by epithelial and osteofibrous components that may be intermingled with each other in various proportions and differentiating patterns.
  • To assure the histological diagnosis, pathologists should employ immunohistochemistry for demonstrating the sometimes sparse epithelial cell nests when the radiological features are suggestive of adamantinoma.
  • There is paucity of compiled data over adamantinoma in the literature, hence authors tried to make a comprehensive review which must be of use to beginners and trained pathologists.
  • Our objective is to further define the clinicoradiologic features and pathologic spectra of adamantinoma.

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  • (PMID = 18279517.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2276480
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3. Kanakaraddi SV, Nagaraj G, Ravinath TM: Adamantinoma of the tibia with late skeletal metastasis: an unusual presentation. J Bone Joint Surg Br; 2007 Mar;89(3):388-9
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  • [Title] Adamantinoma of the tibia with late skeletal metastasis: an unusual presentation.
  • Adamantinoma is a rare tumour of long bones that occurs most commonly in the tibia.
  • [MeSH-major] Adamantinoma / secondary. Bone Neoplasms / pathology. Femoral Neoplasms / secondary. Tibia

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  • (PMID = 17356156.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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4. Hatori M, Watanabe M, Hosaka M, Sasano H, Narita M, Kokubun S: A classic adamantinoma arising from osteofibrous dysplasia-like adamantinoma in the lower leg: a case report and review of the literature. Tohoku J Exp Med; 2006 May;209(1):53-9

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  • [Title] A classic adamantinoma arising from osteofibrous dysplasia-like adamantinoma in the lower leg: a case report and review of the literature.
  • Adamantinoma is known as a low-grade malignant biphasic tumor.
  • Classic adamantinoma is in general characterized by admixture of both epithelial and osteofibrous components that are associated with various proportions and differentiation patterns.
  • OFD-like adamantinoma is characterized by predominance of osteofibrous tissues, in which small groups of epithelial cells are only detected by careful search or immunohistochemistry.
  • There have been controversies as to the potential correlation among OFD, OFD-like adamantinoma and classic adamantinoma.
  • We report an unusual case of adamantinoma arising in the tibia, with an extensive review of the literature.
  • The present findings suggest a direct correlation between OFD-like adamantinoma and classic adamantinoma.
  • The biopsy lesion was diagnosed as classic adamantinoma.
  • The primary lesion was retrospectively diagnosed as OFD-like adamantinoma because of presence of keratin-positive epithelial cells within the stroma.
  • The retrospective histological findings of OFD-like adamantinoma in the original biopsy and of a classic adamantinoma in all sections of the later resection specimen raised the possibility of an unusual progression of OFD-like adamantinoma to a classic adamantinoma.
  • The present case and the literature review suggest that an OFD-like adamantinoma may be a precursor lesion of classic adamantinoma.
  • Therefore, the possibility of progression of OFD-like adamantinoma to a classic adamantinoma should be kept in mind, particularly when the destructive changes are seen radiologically.
  • [MeSH-major] Adamantinoma / physiopathology. Bone Diseases, Developmental / physiopathology. Leg

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  • (PMID = 16636523.001).
  • [ISSN] 0040-8727
  • [Journal-full-title] The Tohoku journal of experimental medicine
  • [ISO-abbreviation] Tohoku J. Exp. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 19
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5. Park YK, Ryu KN, Han CS: Synchronous intracortical adamantinomas with keratin cyst formation. Skeletal Radiol; 2006 Mar;35(3):185-9
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  • [Title] Synchronous intracortical adamantinomas with keratin cyst formation.
  • Adamantinoma of the long bones is a rare primary bone tumor of uncertain embryogenesis.
  • We report on adamantinomas occurring in a 16-year-old male patient, with synchronous tibial and fibular lesions.
  • This keratin cyst formation is quite an unusual finding in classic adamantinoma.
  • [MeSH-major] Adamantinoma / diagnosis. Bone Cysts / diagnosis. Bone Neoplasms / diagnosis. Fibula / pathology. Keratins / analysis. Magnetic Resonance Imaging. Tibia / pathology

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  • (PMID = 16217667.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 68238-35-7 / Keratins
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6. Dini LI, Mendonça R, Adamy CA, Saraiva GA: Adamantinoma of the Spine: Case Report. Neurosurgery; 2006 Aug 01;59(2):E426

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  • [Title] Adamantinoma of the Spine: Case Report.

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  • (PMID = 28180646.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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7. Ulmar B, Delling G, Werner M, Huch K, Reichel H: Classical and atypical location of adamantinomas--presentation of two cases. Onkologie; 2006 Jun;29(6):276-8
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  • [Title] Classical and atypical location of adamantinomas--presentation of two cases.
  • BACKGROUND: Adamantinomas are rare low-grade primary bone tumors of unknown histological origin.
  • The diagnostic work-up including biopsy verified an adamantinoma in both cases.
  • CONCLUSION: Adamantinomas of the short bones are rarely reported.
  • [MeSH-major] Adamantinoma / diagnosis. Adamantinoma / surgery. Bone Neoplasms / diagnosis. Bone Neoplasms / surgery. Metatarsal Bones / surgery. Tibia / surgery

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  • (PMID = 16783903.001).
  • [ISSN] 0378-584X
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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8. Namba Y, Kimata Y, Koshima I, Sugihara S, Sato T: Fibular osteoadiposal flap for treatment of tibial adamantinoma: a case report. Acta Med Okayama; 2006 Aug;60(4):233-6
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  • [Title] Fibular osteoadiposal flap for treatment of tibial adamantinoma: a case report.
  • We treated a case with left tibial adamantinoma by use of a contralateral fibular osteoadiposal flap.
  • [MeSH-major] Adamantinoma / surgery. Bone Neoplasms / surgery. Fibula / surgery. Skin Transplantation. Surgical Flaps. Tibia / surgery

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  • (PMID = 16943861.001).
  • [ISSN] 0386-300X
  • [Journal-full-title] Acta medica Okayama
  • [ISO-abbreviation] Acta Med. Okayama
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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9. Piña-Oviedo S, Del Valle L, Padilla-Longoria R, Mendoza-Ramón H, Ortiz-Hidalgo C: Primary adamantinoma of the rib. Unusual presentation for a bone neoplasm of uncertain origin. Pathol Oncol Res; 2008 Dec;14(4):497-502
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  • [Title] Primary adamantinoma of the rib. Unusual presentation for a bone neoplasm of uncertain origin.
  • Adamantinomas are rare, low-grade malignant intra-osseous tumors composed of epithelial and mesenchymal elements, which show a marked predilection for the tibia and fibula of young adult male patients.
  • Although cases of adamantinoma located to the axial skeleton have been reported either as recurrent or metastatic disease, only two cases of primary adamantinoma located to the thoracic wall have been previously described.
  • In this study we present the clinical, radiological and histopathological features of a 24-year-old male with a slow growing, solid-cystic, painful mass, located to the right 11th rib, which was morphological and immunohistochemically diagnosed as a primary classic adamantinoma.
  • Primary affection of the rib is an unusual feature of classic adamantinomas.
  • [MeSH-major] Adamantinoma / pathology. Ribs / pathology

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  • (PMID = 18409022.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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10. Gleason BC, Liegl-Atzwanger B, Kozakewich HP, Connolly S, Gebhardt MC, Fletcher JA, Perez-Atayde AR: Osteofibrous dysplasia and adamantinoma in children and adolescents: a clinicopathologic reappraisal. Am J Surg Pathol; 2008 Mar;32(3):363-76
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  • [Title] Osteofibrous dysplasia and adamantinoma in children and adolescents: a clinicopathologic reappraisal.
  • Osteofibrous dysplasia (OFD) and adamantinoma are rare and most commonly arise in the tibia of young individuals.
  • Although OFD has typical histopathologic features, areas resembling OFD have often been noted at the periphery of otherwise classic adamantinomas, and some have suggested that OFD may be either a precursor to or a regressive phase of adamantinoma.
  • The so-called OFD-like adamantinoma encompasses some features of both OFD and adamantinoma.
  • We studied the clinical, imaging, histopathologic, immunohistochemical, ultrastructural, and molecular features of 16 OFD and 8 adamantinomas (5 OFD-like and 3 classic) in an attempt to further define their morphology, clinical course, and relationship.
  • Patients with OFD were generally younger than those with adamantinoma.
  • Osteoblastic and osteoclastic activity was more prominent in OFD than in OFD-like adamantinoma.
  • In addition to the inconspicuous small clusters of epithelial cells in OFD-like adamantinoma, isolated keratin-positive cells with a unique ultrastructural hybrid fibroblastic-epithelial phenotype were found in the stroma of all OFD and OFD-like adamantinomas.
  • Fluorescence in situ hybridization analysis revealed trisomies 7, 8, and/or 12 in the spindle cell stroma of OFD, OFD-like, and classic adamantinoma, supporting a neoplastic origin of OFD and a common histogenesis for all 3 lesions.
  • Of the 11 OFD patients with follow-up (median, 4.5 y), all 3 who underwent incisional biopsy had persistent, nonprogressive disease and 2 of 8 who underwent curettage or wide excision had recurrence; none developed adamantinoma.
  • All 6 adamantinoma patients with follow-up (3 classic and 3 OFD-like) were treated with wide excision.
  • One with classic adamantinoma died of pulmonary metastases 9 years after presentation; the other 5 were free of disease with a median follow-up of 12 years.
  • None of the classic adamantinomas evolved into OFD-like adamantinoma or OFD.
  • Although the histopathology, immunohistochemistry, ultrastructure, and cytogenetics indicate that these lesions are closely related, our data and the literature suggest that only classic adamantinoma has malignant potential.
  • OFD, OFD-like adamantinoma, and classic adamantinoma appear to show a progressive complexity of cytogenetic aberrations, perhaps indicative of a multistep neoplastic transformation.
  • [MeSH-major] Adamantinoma / pathology. Bone Neoplasms / pathology. Fibrous Dysplasia of Bone / pathology

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  • (PMID = 18300815.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Izquierdo FM, Ramos LR, Sánchez-Herráez S, Hernández T, de Alava E, Hazelbag HM: Dedifferentiated classic adamantinoma of the tibia: a report of a case with eventual complete revertant mesenchymal phenotype. Am J Surg Pathol; 2010 Sep;34(9):1388-92
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  • [Title] Dedifferentiated classic adamantinoma of the tibia: a report of a case with eventual complete revertant mesenchymal phenotype.
  • Adamantinomas of the long bones are low-grade malignant tumours.
  • We report a case of an adamantinoma with a revertant sarcomatoid transformation that showed a complete loss of epithelial differentiation.
  • On the en bloc resection specimen, areas of classic adamantinoma were found but most of the tumor corresponded to a high-grade neoplasm with 2 histologic patterns: one made up by epithelial nests with a basaloid arrangement and positive for pankeratins and so-called glandular keratins, and a second sarcomatoid component, negative for these epithelial markers.
  • Five months after surgery the patient had a massive relapse that consisted solely of the second sarcomatous component also negative for epithelial antibodies.Three cases of adamantinomas with sarcomatoid transformation of the epithelial component have been described but the tumours still preserved an epithelial immunophenotype.
  • However, our case represents the extreme end of the sarcomatoid dedifferentiation of a classic adamantinoma with complete sarcomatoid transformation and total loss of epithelial markers.
  • [MeSH-major] Adamantinoma / pathology. Bone Neoplasms / pathology. Sarcoma / pathology. Tibia / pathology

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  • (PMID = 20717000.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Biomarkers, Tumor; 0 / CAM 5.2 antigen; 68238-35-7 / Keratins
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12. Roque P, Mankin HJ, Rosenberg A: Adamantinoma: an unusual bone tumour. Chir Organi Mov; 2008 Dec;92(3):149-54
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  • [Title] Adamantinoma: an unusual bone tumour.
  • Adamantinoma is a rare tumour, which most often affects the tibia and produces lytic and sometimes destructive lesions, which can cause fractures.
  • Our institution has treated 42 patients with adamantinomas since 1972 and has evaluated them by imaging studies and histology.
  • Only three of the patients died of disease with the time until death ranging from 10 to 17 years.
  • [MeSH-major] Adamantinoma / pathology. Adamantinoma / radiography. Bone Neoplasms / pathology. Bone Neoplasms / radiography. Tibia / pathology. Tibia / radiography

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  • (PMID = 19030952.001).
  • [ISSN] 1973-2538
  • [Journal-full-title] La Chirurgia degli organi di movimento
  • [ISO-abbreviation] Chir Organi Mov
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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13. Khanna M, Delaney D, Tirabosco R, Saifuddin A: Osteofibrous dysplasia, osteofibrous dysplasia-like adamantinoma and adamantinoma: correlation of radiological imaging features with surgical histology and assessment of the use of radiology in contributing to needle biopsy diagnosis. Skeletal Radiol; 2008 Dec;37(12):1077-84

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  • [Title] Osteofibrous dysplasia, osteofibrous dysplasia-like adamantinoma and adamantinoma: correlation of radiological imaging features with surgical histology and assessment of the use of radiology in contributing to needle biopsy diagnosis.
  • OBJECTIVES: The aim of this study was to correlate the imaging features with surgical histology for tibial osteofibrous dysplasia (OFD), osteofibrous dysplasia-like adamantinoma (OFD/LA) and classical adamantinoma and to determine the additional role of imaging in suggesting a correct diagnosis in cases of needle biopsy misdiagnosis.
  • RESULTS: The 24 cases comprised five OFD, 11 OFD/LA and eight adamantinoma based on surgical resection histology.
  • The mean length of OFD was 6.1 cm (range 2-8.5 cm), for OFD/LA was 6.5 cm (range 2-13 cm) and for adamantinoma was 13.2 cm (range 6.5-26 cm).
  • Seven of eight adamantinomas had moth-eaten margins compared to five of 11 OFD/LA and two of five OFDs.
  • Three of eight adamantinomas demonstrated cortical destruction, with seven of eight cases completely involving the marrow cavity.
  • Four of 19 cases had a different needle biopsy result compared to the final histology, three cases being upgraded from an OFD/LA or OFD to classical adamantinoma.
  • The radiological features of these three cases were more in keeping with a diagnosis of adamantinoma.
  • CONCLUSIONS: A diagnosis of classical adamantinoma is suggested by an extensive lesion with moth-eaten margins and complete involvement of the medullary cavity on axial MR imaging.
  • [MeSH-major] Adamantinoma / diagnosis. Adamantinoma / surgery. Fibrous Dysplasia of Bone / diagnosis. Fibrous Dysplasia of Bone / surgery

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  • (PMID = 18690429.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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14. Frey SP, Hardes J, Ahrens H, Winkelmann W, Gosheger G: Total tibia replacement using an allograft (in a patient with adamantinoma). Case report and review of literature. J Cancer Res Clin Oncol; 2008 Apr;134(4):427-31

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Total tibia replacement using an allograft (in a patient with adamantinoma). Case report and review of literature.
  • INTRODUCTION: Adamantinoma is a very rare, low-grade, malignant bone tumour that accounts for approximately 0.4% of all primary bone tumours.
  • Radiographically, adamantinomas vary in length, have a clearly defined outline, with a bubbly appearance and increase the width of the bone.
  • CASE PRESENTATION: We present a case of adamantinoma of the tibia, in which a resection of the whole tibia and reconstruction with a total tibia allograft was necessary.
  • It is often difficult to distinguish an adamantinoma from other tumours.
  • The most frequent described method to treat adamantinoma is wide resection and the use of an allograft.
  • [MeSH-major] Adamantinoma / surgery. Tibia / surgery

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  • (PMID = 18060426.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 16
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15. van den Berg H, Slaar A, Kroon HM, Taminiau AH, Hogendoorn P: Results of diagnostic review in pediatric bone tumors and tumorlike lesions. J Pediatr Orthop; 2008 Jul-Aug;28(5):561-4
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  • Thirteen of the 60 malignant tumors were not recognized as malignant.
  • Seven of 198 benign lesions were reclassified as malignant.
  • Adamantinomas were not recognized in non-bone tumor centers.

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  • (PMID = 18580373.001).
  • [ISSN] 0271-6798
  • [Journal-full-title] Journal of pediatric orthopedics
  • [ISO-abbreviation] J Pediatr Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Makhson AN, Bulycheva IV, Kuz'min IV, Pavlenko TV: [Adamantinoma of long tubal bones]. Arkh Patol; 2006 Jan-Feb;68(1):14-8

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  • [Title] [Adamantinoma of long tubal bones].
  • Four cases of adamantinomas of the long tubular bones, ulna and femur among them which rarely occur in patients aged 18-64 years (one female) are reported.
  • [MeSH-major] Adamantinoma / ultrastructure. Femoral Neoplasms / ultrastructure. Tibia / ultrastructure

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  • (PMID = 16544529.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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17. Van Rijn R, Bras J, Schaap G, van den Berg H, Maas M: Adamantinoma in childhood: report of six cases and review of the literature. Pediatr Radiol; 2006 Oct;36(10):1068-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adamantinoma in childhood: report of six cases and review of the literature.
  • BACKGROUND: Adamantinoma is a rare slow-growing malignant bone tumour.
  • MATERIALS AND METHODS: The database of the Working Group on Paediatric Oncology, Academic Medical Centre/Emma Children's Hospital Amsterdam, was searched for cases of adamantinoma.
  • Additionally a literature study was performed to identify cases of adamantinoma in childhood.
  • RESULTS: We identified six local cases of adamantinoma of the long bones, two boys (age 3 and 8 years) and four girls (mean age 8.8 years, range 3.0-14.0 years).
  • On follow-up (mean 6.1 years, range 1.6-12.0 years) all children remained disease-free.
  • Besides a discussion of our six patients, imaging features, histopathology, surgical approach and a literature review of childhood adamantinomas is presented.
  • CONCLUSION: Although the incidence of adamantinoma is low, it is important to recognize this rare bone tumour, since in the early stages of the disease adequate treatment will result in an excellent prognosis.
  • [MeSH-major] Adamantinoma / diagnosis

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  • (PMID = 16906392.001).
  • [ISSN] 0301-0449
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 59
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18. Kitsoulis P, Charchanti A, Paraskevas G, Marini A, Karatzias G: Adamantinoma. Acta Orthop Belg; 2007 Aug;73(4):425-31
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  • [Title] Adamantinoma.
  • Adamantinoma is one of the rarest low-grade malignant bone tumours, representing less than 1% of them.
  • Fisher in 1913 named this tumour adamantinoma because of its similarity to ameloblastoma of the jaw.
  • Young males are more prone to develop adamantinoma than females.
  • [MeSH-major] Adamantinoma. Bone Neoplasms

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  • (PMID = 17939469.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 58
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19. A J, Kc BR, Basnet SB, Panth R, Shrestha RL, Chand P, Thapa BB: Adamantinoma of tibial shaft. JNMA J Nepal Med Assoc; 2009 Oct-Dec;48(176):331-4
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  • [Title] Adamantinoma of tibial shaft.
  • Adamantinoma is an extremely rare primary bony neoplasm.
  • Because of its malignant nature, accurate and early diagnosis is very important.
  • On the other hand adamantinoma mimics many benign conditions, so it is doubly important to establish correct tissue diagnosis to avoid radical surgery with morbidities.
  • Because of its rarity, diagnosing adamantinoma still remains difficult, even if when it occurs in classical sites.
  • We report a case of adamantinoma of tibial shaft diaphysis in a 23 year male.
  • In this case, because of classic clinic-radiological features, we were suspecting adamantinoma from very beginning but final diagnosis was delayed for nine months.
  • [MeSH-major] Adamantinoma / diagnosis. Bone Neoplasms / diagnosis. Tibia

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  • (PMID = 21105562.001).
  • [ISSN] 0028-2715
  • [Journal-full-title] JNMA; journal of the Nepal Medical Association
  • [ISO-abbreviation] JNMA J Nepal Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nepal
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20. Most MJ, Sim FH, Inwards CY: Osteofibrous dysplasia and adamantinoma. J Am Acad Orthop Surg; 2010 Jun;18(6):358-66
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  • [Title] Osteofibrous dysplasia and adamantinoma.
  • Adamantinoma (AD) is a rare, low-grade malignant primary bone tumor that occurs most often in the tibia and/or fibula of adolescent persons and young adults; however, it has been reported in other long bones, as well.
  • More recently, published reports have described another clinical entity-differentiated or OFD-like AD-that appears to lie between OFD and AD along a spectrum of disease.
  • [MeSH-major] Adamantinoma / pathology. Adamantinoma / surgery. Bone Neoplasms / pathology. Bone Neoplasms / surgery. Fibrous Dysplasia of Bone / pathology. Fibrous Dysplasia of Bone / surgery

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  • (PMID = 20511441.001).
  • [ISSN] 1067-151X
  • [Journal-full-title] The Journal of the American Academy of Orthopaedic Surgeons
  • [ISO-abbreviation] J Am Acad Orthop Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 46
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21. Cappuccio M, Montalti M, Bosco G, Gasbarrini A, Boriani S: Unusual radiographic appearance of adamantinoma. Orthopedics; 2009 Dec;32(12):926
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual radiographic appearance of adamantinoma.
  • Adamantinoma is a rare tumor with an indolent course that occurs most commonly in the tibia.
  • Microscopically, adamantinoma consists of islands of epithelial cells in a fibrous stroma.
  • Diagnosis of adamantinoma was performed.
  • At 2-year follow-up, there were no clinical or radiological signs of recurrence of disease.
  • [MeSH-major] Adamantinoma / radiography. Adamantinoma / surgery. Bone Neoplasms / radiography. Bone Neoplasms / surgery. Tibia / radiography. Tibia / surgery

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  • [Copyright] Copyright 2009, SLACK Incorporated.
  • (PMID = 19968233.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Dini LI, Mendonça R, Adamy CA, Saraiva GA: Adamantinoma of the spine: case report. Neurosurgery; 2006 Aug;59(2):E426; discussion E426
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  • [Title] Adamantinoma of the spine: case report.
  • OBJECTIVE: We report a patient with a cervicothoracic spinal and a mandibular adamantinoma.
  • Adamantinoma is a rare malignant neoplasm of bone and, to our knowledge, there have been only five cases of spinal adamantinoma reported.
  • The pathogenesis of the adamantinoma, as well as the management of this extremely rare spinal tumor, is reviewed.
  • CONCLUSION: Adamantinoma, an extremely rare lesion, is a locally aggressive tumor with slow growth and the potential to metastasize.
  • Although it is an extremely rare occurrence in the spine, adamantinoma should be considered on the diagnosis of tumors of the vertebrae.
  • This fact, coupled with the limited experience that most physicians in general have in dealing with this tumor, makes the diagnosis and treatment of adamantinoma challenging.
  • [MeSH-major] Adamantinoma / diagnosis. Cervical Vertebrae / pathology. Radiculopathy / etiology. Spinal Neoplasms / diagnosis

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  • (PMID = 16883154.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Napp M, Stengel BA, Buschmann J, Döhler JR: [Osteofibrous dysplasia campanacci of the tibia. A 12-year follow-up]. Chirurg; 2009 Mar;80(3):241-4
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  • Despite the controversial indication, we recommend this method due to the disorder's putative relationship with malignant adamantinoma.

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  • [Cites] Z Orthop Ihre Grenzgeb. 1993 Jan-Feb;131(1):42-50 [8480439.001]
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  • (PMID = 18690418.001).
  • [ISSN] 1433-0385
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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24. Bishop JA, Ali SZ: Primary tibial adamantinoma diagnosed by fine needle aspiration. Diagn Cytopathol; 2010 Mar;38(3):198-201
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary tibial adamantinoma diagnosed by fine needle aspiration.
  • Adamantinoma is one of the rarest primary bone tumors and is almost exclusively found in the tibia.
  • Because of its scarcity, there are only a handful of reported cases of adamantinoma diagnosed by fine needle aspiration (FNA).
  • An immunostain for cytokeratin was positive, supporting the diagnosis of adamantinoma.
  • Due primarily to its rarity, the diagnosis of adamantinoma on FNA can be challenging and must be made in the context of its characteristic clinical and radiographic setting.
  • [MeSH-major] Adamantinoma / diagnosis. Bone Neoplasms / diagnosis. Tibia / pathology

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  • (PMID = 19774617.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
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25. Kitsoulis P, Mantellos G, Xenakis T: Adamantinoma of the tibia: local resection and distraction osteogenesis. Acta Chir Belg; 2009 Jan-Feb;109(1):126-9
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  • [Title] Adamantinoma of the tibia: local resection and distraction osteogenesis.
  • We describe a case of adamantinoma of the distal tibia in a 31-year-old woman.
  • [MeSH-major] Adamantinoma / surgery. Bone Neoplasms / surgery. Osteogenesis, Distraction. Tibia

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  • (PMID = 19341216.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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26. Mathew M, Joseph B: Differentiated adamantinoma: a case report and review of literature. Indian J Pathol Microbiol; 2007 Jul;50(3):565-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differentiated adamantinoma: a case report and review of literature.
  • Adamantinoma of the long bones are uncommon, slow growing tumors with a predilection for the tibia.
  • A special rare variant known as the osteofibrous dysplasia-like adamantinoma or differentiated adamantinoma is thought to be a precursor of the classic adamantinoma.
  • [MeSH-major] Adamantinoma / diagnosis. Bone Neoplasms / diagnosis. Tibia / pathology

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  • (PMID = 17883137.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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27. Chandrasekar CR, Mohammed R, Rafalla AA, Grimer RJ: Adamantinoma of the calcaneum--a case report. Foot (Edinb); 2009 Mar;19(1):58-61
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  • [Title] Adamantinoma of the calcaneum--a case report.
  • Adamantinoma is rare, representing less than 1% of all primary malignant bone tumours.
  • It is a slow growing low grade malignant tumour which is often clinically, radiologically and histologically mistaken for many other tumours like Ewing's sarcoma, synovial sarcoma, fibrosarcoma, metastatic carcinoma, fibrous cortical defect and osteofibrous dysplasia.
  • Adamantinoma commonly occurs in the tibia.
  • Adamantinoma of the foot is extremely rare.
  • To our knowledge adamantinoma of the calcaneum has not been previously reported in the literature.
  • We report the case of a male patient, aged 33 years, who was treated for adamantinoma of the calcaneum and followed for 16 years highlighting the difficulty in diagnosis and management of this rare tumor occurring at a rare site.
  • [MeSH-major] Adamantinoma / pathology. Bone Neoplasms / pathology. Calcaneus / pathology

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  • (PMID = 20307451.001).
  • [ISSN] 1532-2963
  • [Journal-full-title] Foot (Edinburgh, Scotland)
  • [ISO-abbreviation] Foot (Edinb)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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28. Mavrogenis AF, Galanakos S, Savvidou OD, Papagelopoulos PJ: Adamantinoma of the tibia mimicking a benign cystic lesion: a case report. Clin Podiatr Med Surg; 2010 Jan;27(1):157-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adamantinoma of the tibia mimicking a benign cystic lesion: a case report.
  • Adamantinoma of the long bones is a rare primary malignant bone tumor accounting for less than 1% of all primary malignant bone tumors.
  • In this article, the authors present a case report of a patient with a distal tibia adamantinoma mimicking a benign cystic lesion.
  • [MeSH-major] Adamantinoma / diagnosis. Bone Cysts / diagnosis. Bone Neoplasms / diagnosis. Tibia

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  • (PMID = 19963177.001).
  • [ISSN] 1558-2302
  • [Journal-full-title] Clinics in podiatric medicine and surgery
  • [ISO-abbreviation] Clin Podiatr Med Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Al-Daraji WI, Al-Daraji UW, Al-Mahmoud RM: Adamantinoma associated with botryomycosis: the first report of this rare association after trauma. Clin Exp Dermatol; 2008 Jul;33(4):433-6

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  • [Title] Adamantinoma associated with botryomycosis: the first report of this rare association after trauma.
  • We report for the first time to our knowledge a unique case of both botryomycosis and adamantinoma in the right tibia of the same patient at an area of previous trauma.
  • Although both botryomycosis and adamantinoma usually have a history of trauma, as in our patient, a causal relationship will need more cases to establish a possible link.
  • [MeSH-major] Adamantinoma / complications. Granulomatous Disease, Chronic / complications. Staphylococcal Skin Infections / complications. Tibia. Wounds, Nonpenetrating / complications

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  • (PMID = 18312455.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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30. Flowers R, Baliga M, Guo M, Liu SS: Tibial adamantinoma with local recurrence and pulmonary metastasis: report of a case with histocytologic findings. Acta Cytol; 2006 Sep-Oct;50(5):567-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tibial adamantinoma with local recurrence and pulmonary metastasis: report of a case with histocytologic findings.
  • BACKGROUND: Adamantinoma is a rare primary bone neoplasm of low malignant potential that may recur or metastasize in a mall percentage of patients.
  • CASE: A 32-year-old man presented with a mass in the distal side of the left leg that was diagnosed as classic adamantinoma by open biopsy.
  • CONCLUSION: The diagnosis of adamantinoma requires knowledge of compatible clinical and radiologic studies as well as understanding of the variable histologic patterns that one may encounter.
  • Fine needle aspiration biopsy is particularly useful in the diagnosis of recurrent and metastatic adamantinoma.
  • This case report describes a distinctive cytomorphologic feature of nuclear grooves that may be a useful aid in distinguishing the tumor cells of adamantinoma from other cell types.
  • [MeSH-major] Adamantinoma / diagnosis. Bone Neoplasms / diagnosis. Lung / pathology. Lung Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis. Tibia / pathology
  • [MeSH-minor] Adult. Amputation. Biomarkers, Tumor / analysis. Biomarkers, Tumor / biosynthesis. Biopsy, Fine-Needle. Cell Shape. Diagnosis, Differential. Disease Progression. Epithelial Cells / pathology. Humans. Magnetic Resonance Imaging. Male. Nuclear Envelope / pathology. Prognosis

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  • (PMID = 17017449.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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31. Panchwagh Y, Puri A, Agarwal M, Chinoy R, Jambhekar N: Case report: metastatic adamantinoma of the tibia--an unusual presentation. Skeletal Radiol; 2006 Mar;35(3):190-3
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  • [Title] Case report: metastatic adamantinoma of the tibia--an unusual presentation.
  • A 26-year-old female with a tibial lesion diagnosed as an adamantinoma was treated with intra-lesional curettage, bone grafting and intra-medullary nailing.
  • Although cases of local recurrences and pulmonary metastases in adamantinoma are reported, this case is unusual in presenting without a local recurrence but with simultaneous skeletal and pulmonary metastases.
  • [MeSH-major] Adamantinoma / secondary. Bone Neoplasms / pathology. Femoral Neoplasms / secondary. Lung Neoplasms / secondary. Tibia

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  • (PMID = 16402219.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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32. Fujii H, Honoki K, Enomoto Y, Kasai T, Kido A, Amano I, Kumamoto M, Morishita T, Mii Y, Nonomura A, Takakura Y: Adamantinoma-like Ewing's sarcoma with EWS-FLI1 fusion gene: a case report. Virchows Arch; 2006 Nov;449(5):579-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adamantinoma-like Ewing's sarcoma with EWS-FLI1 fusion gene: a case report.
  • Recent studies have advocated the genotypic and phenotypic delineation of a novel Ewing's sarcoma histologic variant showing epithelial features defined as "adamantinoma-like Ewing's sarcoma".
  • The diagnosis of the lesion was confirmed as Ewing's sarcoma by the presence of the EWS-FLI1 fusion transcript, and could be defined as the so-called "adamantinoma-like Ewing's sarcoma".
  • [MeSH-major] Adamantinoma / pathology. Bone Neoplasms / pathology. Oncogene Proteins, Fusion / genetics. Proto-Oncogene Protein c-fli-1 / genetics. Sarcoma, Ewing / pathology

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  • (PMID = 17016721.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / EWS-FLI fusion protein; 0 / Oncogene Proteins, Fusion; 0 / Proto-Oncogene Protein c-fli-1; 0 / RNA-Binding Protein EWS
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33. Desai SS, Jambhekar N, Agarwal M, Puri A, Merchant N: Adamantinoma of tibia: a study of 12 cases. J Surg Oncol; 2006 Apr 1;93(5):429-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adamantinoma of tibia: a study of 12 cases.
  • BACKGROUND: Adamantinoma is a rare tumor of long bones that can be mistaken for a carcinoma, and numerous other lesions such as myoepithelial tumor, malignant mixed tumor of bone, fibrous dysplasia/osteofibrous dysplasia, and vascular tumors.
  • DISCUSSION: In this article, an attempt is made to study the morphology, biology, and the differential diagnoses of adamantinoma of long bones.
  • [MeSH-major] Adamantinoma. Bone Neoplasms. Tibia

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16550582.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 30
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34. Mavrogenis AF, Sakellariou VI, Tsibidakis H, Papagelopoulos PJ: Adamantinoma of the tibia treated with a new intramedullary diaphyseal segmental defect implant. J Int Med Res; 2009 Jul-Aug;37(4):1238-45

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  • [Title] Adamantinoma of the tibia treated with a new intramedullary diaphyseal segmental defect implant.
  • Histological diagnosis was consistent with adamantinoma, a rare primary bone tumour.
  • [MeSH-major] Adamantinoma / pathology. Adamantinoma / surgery. Limb Salvage / methods. Tibia / pathology. Tibia / surgery

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  • (PMID = 19761710.001).
  • [ISSN] 0300-0605
  • [Journal-full-title] The Journal of international medical research
  • [ISO-abbreviation] J. Int. Med. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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35. Szendroi M, Antal I, Arató G: Adamantinoma of long bones: a long-term follow-up study of 11 cases. Pathol Oncol Res; 2009 Jun;15(2):209-16
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  • [Title] Adamantinoma of long bones: a long-term follow-up study of 11 cases.
  • The aim of this study was to evaluate the clinicopathological features and prognostic significances of 11 histologically proven adamantinoma cases based on an average 12,7 year long follow-up.
  • The initial diagnosis at referral was other than adamantinoma in six patients (fibrous dysplasia, carcinoma metastasis, osteofibrous dysplasia, bone cyst, non-ossifying fibroma), referring to the differential diagnostic problems.
  • All adamantinoma were positive for cytokeratins often in coexpression with vimentin.
  • Adamantinoma of the long bones is a low grade malignant tumor, which clinical outcome is difficult to predict based on histology or surgical stage of the tumor.
  • [MeSH-major] Adamantinoma / pathology. Bone Neoplasms / pathology. Tibia

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  • (PMID = 19048403.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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36. Spiegelberg BG, Sewell MD, Coltman T, Blunn GW, Flanagan AM, Cannon SR, Briggs TW: Below-knee amputation through a joint-sparing proximal tibial replacement for recurrent tumour. J Bone Joint Surg Br; 2009 Jun;91(6):815-9
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  • We report a case which highlights the progression of osteofibrous dysplasia to adamantinoma and questions whether intralesional curettage is the appropriate treatment.
  • [MeSH-major] Adamantinoma / surgery. Amputation / methods. Bone Diseases, Developmental / surgery. Bone Neoplasms / surgery. Neoplasm Recurrence, Local / surgery
  • [MeSH-minor] Adult. Diagnosis, Differential. Disease Progression. Female. Humans. Pain / surgery. Skiing / injuries. Tibial Fractures / complications

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  • [ErratumIn] J Bone Joint Surg Br. 2009 Aug;91(8):1120. Speigelberg, B G I [corrected to Spiegelberg B G I]
  • (PMID = 19483239.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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37. Requena L, Kutzner H: Seborrheic keratosis with pseudorosettes and adamantinoid seborrheic keratosis: two new histopathologic variants. J Cutan Pathol; 2006 Sep;33 Suppl 2:42-5
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  • RESULTS: One lesion showed abundant intercellular mucin, closely resembling to adamantinoma, and therefore was named adamantinoid seborrheic keratosis.
  • [MeSH-major] Adamantinoma / pathology. Keratinocytes / pathology. Keratosis, Seborrheic / pathology. Skin Neoplasms / pathology

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  • (PMID = 16972954.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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38. Weber K, Damron TA, Frassica FJ, Sim FH: Malignant bone tumors. Instr Course Lect; 2008;57:673-88
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  • [Title] Malignant bone tumors.
  • Malignant bone tumors represent a small percentage of cancers nationwide and also are much less common than malignant soft-tissue tumors.
  • The most common primary malignant bone tumors, osteosarcoma and Ewing's sarcoma, occur in childhood.
  • Rare tumors such as chordoma and adamantinoma have anatomic predilections for the sacrum and tibia, respectively.
  • The primary symptom of a patient with a malignant bone tumor is pain, which often occurs at rest or at night.
  • Patients with a likely malignancy require thorough staging to determine the extent of disease and a well-planned biopsy for accurate diagnosis.
  • Knowledge of specific tumor characteristics and treatment options for osteosarcoma, Ewing's sarcoma, chondrosarcoma, malignant fibrous histiocytoma, chordoma, and adamantinoma is important.
  • Specific techniques are available for the resection of malignant bone tumors from the upper extremities, lower extremities, pelvis, and spine.
  • The care of patients with primary malignant bone tumors requires a multidisciplinary approach to treatment.

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  • (PMID = 18399615.001).
  • [ISSN] 0065-6895
  • [Journal-full-title] Instructional course lectures
  • [ISO-abbreviation] Instr Course Lect
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 42
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39. Hahn SB, Kim SH, Cho NH, Choi CJ, Kim BS, Kang HJ: Treatment of osteofibrous dysplasia and associated lesions. Yonsei Med J; 2007 Jun 30;48(3):502-10

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  • PURPOSE: To report long term treatment outcomes of osteofibrous dysplasia and association with adamantinoma.
  • After the initial pathology slides of the 13 patients were reviewed with immunohistochemical cytokeratin staining, one patient diagnosis was changed from osteofibrous dysplasia to osteofibrous dysplasia-like adamantinoma.
  • CONCLUSION: Some patients with osteofibrous dysplasia require close observation because of the high association risk between osteofibrous dysplasia and adamantinoma, Immunohistochemical staining may be helpful in differentiating these two diagnoses.
  • [MeSH-major] Adamantinoma / surgery. Fibrous Dysplasia of Bone / surgery

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  • [Cites] J Bone Joint Surg Am. 1981 Mar;63(3):483-8 [7204453.001]
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  • (PMID = 17594160.001).
  • [ISSN] 0513-5796
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 68238-35-7 / Keratins
  • [Other-IDs] NLM/ PMC2628088
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40. Folpe AL, Goldblum JR, Rubin BP, Shehata BM, Liu W, Dei Tos AP, Weiss SW: Morphologic and immunophenotypic diversity in Ewing family tumors: a study of 66 genetically confirmed cases. Am J Surg Pathol; 2005 Aug;29(8):1025-33
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  • Histologically, 46 cases (73%) showed only typical features of ES, 9 cases (16%) showed features of PNET, 3 cases (5%) showed "adamantinoma-like" features, 3 cases (5%) corresponded to "atypical Ewing sarcoma," 3 cases (5%) showed principally intersecting fascicles of spindled cells, and 2 cases had abundant hyalinized matrix.
  • HMWCK was expressed only in "adamantinoma-like" EFTs, none of which expressed DES.
  • However, genetic confirmation remains essential for the diagnosis of unusual morphologic variants of EFT, including "adamantinoma-like," spindled, sclerosing, and clear cell/anaplastic variants.

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  • (PMID = 16006796.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Desmin; 0 / FLII protein, human; 0 / Gelsolin; 0 / Microfilament Proteins; 0 / Receptors, Cytoplasmic and Nuclear; 68238-35-7 / Keratins; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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41. Jeon DG, Lee SY, Kim JW: Bone primary sarcomas undergone unplanned intralesional procedures - the possibility of limb salvage and their oncologic results. J Surg Oncol; 2006 Dec 1;94(7):592-8
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  • There were 22 (88%) cases of osteosarcomas, 2 (8%) MFH of bone and 1 (4%) adamantinoma.

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 17066433.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Łapienis M, Kaczmarczyk D, Zimmer-Nowicka J, Niedźwiecka I, Jesionek-Kupnicka D, Morawiec-Bajda A: [Ameloblastoma of the maxillary sinus--a case report]. Otolaryngol Pol; 2008;62(6):784-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Szkliwiak zatoki szczekowej--opis przypadku.
  • Ameloblastoma (adamantinoma) is a benign neoplasm deriving from the enamel organ.

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  • (PMID = 19205533.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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43. Lee RS, Weitzel S, Eastwood DM, Monsell F, Pringle J, Cannon SR, Briggs TW: Osteofibrous dysplasia of the tibia. Is there a need for a radical surgical approach? J Bone Joint Surg Br; 2006 May;88(5):658-64
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  • The possible link with adamantinoma is controversial and some authors believe that they are part of one histological process.
  • There were three confirmed cases of adamantinoma.
  • [MeSH-minor] Adamantinoma / pathology. Adamantinoma / radiography. Adamantinoma / surgery. Adolescent. Adult. Child. Child, Preschool. Curettage / methods. Diagnosis, Differential. Female. Fibula / transplantation. Humans. Male. Orthopedic Procedures / methods. Recurrence. Retrospective Studies

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  • [CommentIn] J Bone Joint Surg Br. 2007 Jan;89(1):141 [17259434.001]
  • (PMID = 16645116.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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44. Almeida Herrero F, Silvestre Muñoz A, Martinez Rodriguez M, Gomar Sancho F: Ossifying fibroma of long bones in adults: a case report. Acta Orthop Belg; 2006 Dec;72(6):786-9
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  • No epitheloid cells are found as in adamantinoma.

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  • (PMID = 17260623.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Bone Substitutes
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45. Papagelopoulos PJ, Savvidou OD, Mavrogenis AF, Galanis EC, Shaughnessy WJ, Unni KK, Sim FH: Lateral malleolus en bloc resection and ankle reconstruction for malignant tumors. Clin Orthop Relat Res; 2005 Aug;(437):209-18
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  • [Title] Lateral malleolus en bloc resection and ankle reconstruction for malignant tumors.
  • Four children and six adults required en bloc resection of the lateral malleolus for malignant tumors.
  • There were four osteosarcomas, three chondrosarcomas, two Ewing's sarcomas, and one adamantinoma.
  • At the latest followup, all 10 patients showed no evidence of disease.

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  • (PMID = 16056051.001).
  • [ISSN] 0009-921X
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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46. Deyrup AT, Montag AG: Epithelioid and epithelial neoplasms of bone. Arch Pathol Lab Med; 2007 Feb;131(2):205-16
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  • CONTEXT: Epithelioid and epithelial neoplasms seen in bone are rare and include epithelioid variants of vascular lesions, osteoblastoma, osteosarcoma, chordoma, and chondroblastoma as well as adamantinoma and metastatic carcinoma.

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  • (PMID = 17284104.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 86
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47. Weinreb I, Goldstein D, Perez-Ordoñez B: Primary extraskeletal Ewing family tumor with complex epithelial differentiation: a unique case arising in the lateral neck presenting with Horner syndrome. Am J Surg Pathol; 2008 Nov;32(11):1742-8
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  • An open biopsy demonstrated a high-grade malignant neoplasm with sheets of undifferentiated round cells infiltrating soft tissues and a large peripheral branch of the vagus nerve.
  • This tumor is related to, if not an example of the recently described "adamantinoma-like" EFT and demonstrates a potential diagnostic pitfall.

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  • (PMID = 18769338.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / EWS-FLI fusion protein; 0 / Membrane Proteins; 0 / Oncogene Proteins, Fusion; 0 / Proto-Oncogene Protein c-fli-1; 0 / RNA-Binding Protein EWS; 68238-35-7 / Keratins
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48. Ramseier LE, Malinin TI, Temple HT, Mnaymneh WA, Exner GU: Allograft reconstruction for bone sarcoma of the tibia in the growing child. J Bone Joint Surg Br; 2006 Jan;88(1):95-9
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  • Two had Ewing's sarcoma, one an adamantinoma and 16 osteosarcoma, one with multifocal disease.
  • Five patients have died; the other 14 were free from disease at the time of follow-up.
  • [MeSH-minor] Adamantinoma / surgery. Adolescent. Child. Female. Follow-Up Studies. Humans. Leg Length Inequality / etiology. Male. Reoperation / methods. Sarcoma, Ewing / surgery. Treatment Outcome. Wound Healing

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  • (PMID = 16365128.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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49. Ieni A, Barresi V, Grosso M, Rosa MA, Tuccari G: Lactoferrin immuno-expression in human normal and neoplastic bone tissue. J Bone Miner Metab; 2009;27(3):364-71

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  • Lactoferrin (Lf) expression was investigated by using a Lf monoclonal antibody in 50 formalin-fixed and paraffin-embedded human bone tumours [10 giant cell tumours (GCTs), 7 osteoid osteomas, 6 ossifying fibromas, 19 enchondromas, 2 chondroblastomas, 2 chondrosarcomas, 2 chondroblastic osteosarcomas, 1 myeloma and 1 adamantinoma] as well as in 8 samples of adult and foetal human normal bone specimens.
  • Lf immuno-expression with a variable ID score was encountered in 19/50 tumours and specifically in 10/10 GCTs, in 5/7 osteoid osteomas, in 2/2 chondroblastomas as well as in the adamantinoma and in the myeloma.

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  • (PMID = 19240970.001).
  • [ISSN] 0914-8779
  • [Journal-full-title] Journal of bone and mineral metabolism
  • [ISO-abbreviation] J. Bone Miner. Metab.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] EC 3.4.21.- / Lactoferrin
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50. Sakellariou VI, Mavrogenis AF, Papagelopoulos PJ: Limb salvage surgery using the intramedullary diaphyseal segmental defect fixation system. J Long Term Eff Med Implants; 2008;18(1):59-67
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  • Histological diagnosis included adamantinoma, synovial sarcoma, multiple myeloma, metastatic renal cell carcinoma, myeloid carcinoma of the thyroid gland, and adenocarcinoma of the stomach.
  • At the latest examination, five patients were free of local or distant disease and one patient had deceased with distant disease, without evidence of local recurrence.

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  • (PMID = 19348612.001).
  • [ISSN] 1050-6934
  • [Journal-full-title] Journal of long-term effects of medical implants
  • [ISO-abbreviation] J Long Term Eff Med Implants
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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51. Llombart-Bosch A, Machado I, Navarro S, Bertoni F, Bacchini P, Alberghini M, Karzeladze A, Savelov N, Petrov S, Alvarado-Cabrero I, Mihaila D, Terrier P, Lopez-Guerrero JA, Picci P: Histological heterogeneity of Ewing's sarcoma/PNET: an immunohistochemical analysis of 415 genetically confirmed cases with clinical support. Virchows Arch; 2009 Nov;455(5):397-411
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  • Ewing's sarcoma (ES)/peripheral neuroectodermal tumor (PNET) are malignant neoplasms affecting children and young adults.
  • This study confirms the structural heterogeneity of ES/PNET, distinguishing three major subtypes: conventional ES (280 cases); PNET (53 cases); and atypical ES/PNET (80), including large cells, vascular-like patterns, spindle pattern, and adamantinoma-like configuration.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD / biosynthesis. Antigens, CD57 / biosynthesis. Caveolin 1 / biosynthesis. Cell Adhesion Molecules / biosynthesis. Child. Child, Preschool. Disease Progression. Female. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Infant. Kaplan-Meier Estimate. Male. Middle Aged. Prognosis. Proto-Oncogene Protein c-fli-1 / biosynthesis. Young Adult

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  • (PMID = 19841938.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies; 0 / Antigens, CD; 0 / Antigens, CD57; 0 / Biomarkers, Tumor; 0 / CAV1 protein, human; 0 / CD99 protein, human; 0 / Caveolin 1; 0 / Cell Adhesion Molecules; 0 / FLI1 protein, human; 0 / Proto-Oncogene Protein c-fli-1
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52. Choi E, Wert M, Guerrieri C, Tucci J: A pathologic fracture of an intracortical chondroma masking as an osteoid osteoma. Orthopedics; 2010 Nov;33(11):845
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  • The differential diagnosis of a tibial intracortical diaphyseal lesion includes osteoid osteoma, periosteal chondroma, nonossifying fibroma, osteofibrous dysplasia, and adamantinoma.

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  • [Copyright] Copyright 2010, SLACK Incorporated.
  • (PMID = 21053879.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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53. Wang J, Zhang RY: [Ectopic hamartomatous thymoma: a clinicopathological and immunohistochemical study of two cases]. Zhonghua Bing Li Xue Za Zhi; 2005 Jul;34(7):397-401
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  • They formed small solid islands and adamantinoma-like "nastomosing cords", or appeared as lining cells in large cystic spaces.

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  • (PMID = 16251042.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Anion Exchange Protein 1, Erythrocyte; 0 / Keratins, Type II; 0 / Mucin-1; 0 / Vimentin
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54. Hoshi M, Matsumoto S, Manabe J, Tanizawa T, Shigemitsu T, Izawa N, Shi X, Kawaguchi N: Surgical treatment for adamantinoma arising from the tibia. J Orthop Sci; 2005 Nov;10(6):665-70
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  • [Title] Surgical treatment for adamantinoma arising from the tibia.
  • [MeSH-major] Adamantinoma / surgery. Bone Neoplasms / surgery. Tibia

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  • (PMID = 16307196.001).
  • [ISSN] 0949-2658
  • [Journal-full-title] Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
  • [ISO-abbreviation] J Orthop Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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55. Camp MD, Tompkins RK, Spanier SS, Bridge JA, Bush CH: Best cases from the AFIP: Adamantinoma of the tibia and fibula with cytogenetic analysis. Radiographics; 2008 Jul-Aug;28(4):1215-20

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  • [Title] Best cases from the AFIP: Adamantinoma of the tibia and fibula with cytogenetic analysis.
  • [MeSH-major] Adamantinoma / diagnosis. Chromosome Aberrations. Fibula / pathology. Fibula / radiography. Tibia / pathology. Tibia / radiography
  • [MeSH-minor] Adolescent. Female. Genetic Predisposition to Disease / genetics. Humans

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  • (PMID = 18635638.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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56. Kiral A, Pehlivan O, Cilli F, Akmaz I, Rodop O, Solakoglu C: Reconstruction of intercalary gap after wide surgical resection of adamantinoma of the tibia. Orthopedics; 2008 Nov;31(11):1143
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  • [Title] Reconstruction of intercalary gap after wide surgical resection of adamantinoma of the tibia.
  • [MeSH-major] Adamantinoma / surgery. Bone Neoplasms / surgery. Bone Transplantation. Limb Salvage / methods. Tibia / surgery

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  • (PMID = 19226080.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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57. Dudek AZ, Murthaiah PK, Franklin M, Truskinovsky AM: Metastatic adamantinoma responds to treatment with receptor tyrosine kinase inhibitor. Acta Oncol; 2010;49(1):101-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic adamantinoma responds to treatment with receptor tyrosine kinase inhibitor.
  • [MeSH-major] Adamantinoma / drug therapy. Adamantinoma / pathology. Antineoplastic Agents / therapeutic use. Indoles / therapeutic use. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Pyrroles / therapeutic use

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  • (PMID = 19412810.001).
  • [ISSN] 1651-226X
  • [Journal-full-title] Acta oncologica (Stockholm, Sweden)
  • [ISO-abbreviation] Acta Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Enzyme Inhibitors; 0 / Indoles; 0 / Pyrroles; 0 / sunitinib; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases
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58. Papagelopoulos PJ, Mavrogenis AF, Galanis EC, Savvidou OD, Inwards CY, Sim FH: Clinicopathological features, diagnosis, and treatment of adamantinoma of the long bones. Orthopedics; 2007 Mar;30(3):211-5; quiz 216-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathological features, diagnosis, and treatment of adamantinoma of the long bones.
  • [MeSH-major] Adamantinoma / diagnosis. Adamantinoma / therapy. Bone Neoplasms / diagnosis. Bone Neoplasms / therapy. Tibia / pathology

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  • (PMID = 17375547.001).
  • [ISSN] 0147-7447
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Review
  • [Publication-country] United States
  • [Number-of-references] 57
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