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1. Namba Y, Kimata Y, Koshima I, Sugihara S, Sato T: Fibular osteoadiposal flap for treatment of tibial adamantinoma: a case report. Acta Med Okayama; 2006 Aug;60(4):233-6
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  • [Title] Fibular osteoadiposal flap for treatment of tibial adamantinoma: a case report.
  • We treated a case with left tibial adamantinoma by use of a contralateral fibular osteoadiposal flap.
  • We present herein the utility of the osteoadiposal flap and show the value of a skin-sparing approach with a minimal aesthetic defect.
  • [MeSH-major] Adamantinoma / surgery. Bone Neoplasms / surgery. Fibula / surgery. Skin Transplantation. Surgical Flaps. Tibia / surgery

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  • (PMID = 16943861.001).
  • [ISSN] 0386-300X
  • [Journal-full-title] Acta medica Okayama
  • [ISO-abbreviation] Acta Med. Okayama
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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2. Kanakaraddi SV, Nagaraj G, Ravinath TM: Adamantinoma of the tibia with late skeletal metastasis: an unusual presentation. J Bone Joint Surg Br; 2007 Mar;89(3):388-9
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  • [Title] Adamantinoma of the tibia with late skeletal metastasis: an unusual presentation.
  • Adamantinoma is a rare tumour of long bones that occurs most commonly in the tibia.
  • [MeSH-major] Adamantinoma / secondary. Bone Neoplasms / pathology. Femoral Neoplasms / secondary. Tibia

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  • (PMID = 17356156.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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3. Hatori M, Watanabe M, Hosaka M, Sasano H, Narita M, Kokubun S: A classic adamantinoma arising from osteofibrous dysplasia-like adamantinoma in the lower leg: a case report and review of the literature. Tohoku J Exp Med; 2006 May;209(1):53-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A classic adamantinoma arising from osteofibrous dysplasia-like adamantinoma in the lower leg: a case report and review of the literature.
  • Adamantinoma is known as a low-grade malignant biphasic tumor.
  • Classic adamantinoma is in general characterized by admixture of both epithelial and osteofibrous components that are associated with various proportions and differentiation patterns.
  • Osteofibrous dysplasia (OFD) is a self-limited benign fibro-osseous lesion of bone during infancy and childhood.
  • OFD-like adamantinoma is characterized by predominance of osteofibrous tissues, in which small groups of epithelial cells are only detected by careful search or immunohistochemistry.
  • There have been controversies as to the potential correlation among OFD, OFD-like adamantinoma and classic adamantinoma.
  • We report an unusual case of adamantinoma arising in the tibia, with an extensive review of the literature.
  • The present findings suggest a direct correlation between OFD-like adamantinoma and classic adamantinoma.
  • At the age of 12 years, the tibial biopsy lesion was diagnosed as OFD.
  • The biopsy lesion was diagnosed as classic adamantinoma.
  • The primary lesion was retrospectively diagnosed as OFD-like adamantinoma because of presence of keratin-positive epithelial cells within the stroma.
  • The retrospective histological findings of OFD-like adamantinoma in the original biopsy and of a classic adamantinoma in all sections of the later resection specimen raised the possibility of an unusual progression of OFD-like adamantinoma to a classic adamantinoma.
  • The present case and the literature review suggest that an OFD-like adamantinoma may be a precursor lesion of classic adamantinoma.
  • Therefore, the possibility of progression of OFD-like adamantinoma to a classic adamantinoma should be kept in mind, particularly when the destructive changes are seen radiologically.
  • [MeSH-major] Adamantinoma / physiopathology. Bone Diseases, Developmental / physiopathology. Leg
  • [MeSH-minor] Adult. Child. Diagnosis, Differential. Female. Humans. Retrospective Studies

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  • (PMID = 16636523.001).
  • [ISSN] 0040-8727
  • [Journal-full-title] The Tohoku journal of experimental medicine
  • [ISO-abbreviation] Tohoku J. Exp. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 19
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4. Jain D, Jain VK, Vasishta RK, Ranjan P, Kumar Y: Adamantinoma: a clinicopathological review and update. Diagn Pathol; 2008;3:8

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  • [Title] Adamantinoma: a clinicopathological review and update.
  • Adamantinoma is a primary low-grade, malignant bone tumor that is predominantly located in the mid-portion of the tibia.
  • The initial symptoms of adamantinoma are often indolent and nonspecific and depend on location and extent of the disease.
  • Histologically, classic adamantinoma is a biphasic tumor characterized by epithelial and osteofibrous components that may be intermingled with each other in various proportions and differentiating patterns.
  • To assure the histological diagnosis, pathologists should employ immunohistochemistry for demonstrating the sometimes sparse epithelial cell nests when the radiological features are suggestive of adamantinoma.
  • There is paucity of compiled data over adamantinoma in the literature, hence authors tried to make a comprehensive review which must be of use to beginners and trained pathologists.
  • Our objective is to further define the clinicoradiologic features and pathologic spectra of adamantinoma.

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  • (PMID = 18279517.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2276480
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5. Lee RS, Weitzel S, Eastwood DM, Monsell F, Pringle J, Cannon SR, Briggs TW: Osteofibrous dysplasia of the tibia. Is there a need for a radical surgical approach? J Bone Joint Surg Br; 2006 May;88(5):658-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Osteofibrous dysplasia of the tibia. Is there a need for a radical surgical approach?
  • Osteofibrous dysplasia is an unusual developmental condition of childhood, which almost exclusively affects the tibia.
  • The possible link with adamantinoma is controversial and some authors believe that they are part of one histological process.
  • Extensive lesions were treated by segmental excision and fibular autograft in six patients, external fixation and bone transport in four and proximal tibial replacement in one.
  • One patient who had a fibular autograft required further excision and bone transport for recurrence.
  • There were no recurrences after localised extraperiosteal excision or bone transport.
  • There were three confirmed cases of adamantinoma.
  • [MeSH-major] Bone Diseases, Developmental / surgery. Tibia / surgery
  • [MeSH-minor] Adamantinoma / pathology. Adamantinoma / radiography. Adamantinoma / surgery. Adolescent. Adult. Child. Child, Preschool. Curettage / methods. Diagnosis, Differential. Female. Fibula / transplantation. Humans. Male. Orthopedic Procedures / methods. Recurrence. Retrospective Studies

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  • [CommentIn] J Bone Joint Surg Br. 2007 Jan;89(1):141 [17259434.001]
  • (PMID = 16645116.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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6. A J, Kc BR, Basnet SB, Panth R, Shrestha RL, Chand P, Thapa BB: Adamantinoma of tibial shaft. JNMA J Nepal Med Assoc; 2009 Oct-Dec;48(176):331-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adamantinoma of tibial shaft.
  • Adamantinoma is an extremely rare primary bony neoplasm.
  • Because of its malignant nature, accurate and early diagnosis is very important.
  • On the other hand adamantinoma mimics many benign conditions, so it is doubly important to establish correct tissue diagnosis to avoid radical surgery with morbidities.
  • Because of its rarity, diagnosing adamantinoma still remains difficult, even if when it occurs in classical sites.
  • We report a case of adamantinoma of tibial shaft diaphysis in a 23 year male.
  • In this case, because of classic clinic-radiological features, we were suspecting adamantinoma from very beginning but final diagnosis was delayed for nine months.
  • [MeSH-major] Adamantinoma / diagnosis. Bone Neoplasms / diagnosis. Tibia

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  • (PMID = 21105562.001).
  • [ISSN] 0028-2715
  • [Journal-full-title] JNMA; journal of the Nepal Medical Association
  • [ISO-abbreviation] JNMA J Nepal Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nepal
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7. Desai SS, Jambhekar N, Agarwal M, Puri A, Merchant N: Adamantinoma of tibia: a study of 12 cases. J Surg Oncol; 2006 Apr 1;93(5):429-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adamantinoma of tibia: a study of 12 cases.
  • BACKGROUND: Adamantinoma is a rare tumor of long bones that can be mistaken for a carcinoma, and numerous other lesions such as myoepithelial tumor, malignant mixed tumor of bone, fibrous dysplasia/osteofibrous dysplasia, and vascular tumors.
  • Radiologically the tumor presented as a lytic, eccentric, intracortical lesion in the tibia.
  • DISCUSSION: In this article, an attempt is made to study the morphology, biology, and the differential diagnoses of adamantinoma of long bones.
  • [MeSH-major] Adamantinoma. Bone Neoplasms. Tibia
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Fibrous Dysplasia of Bone / diagnosis. Fibula / pathology. Humans. Male. Treatment Outcome

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16550582.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 30
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8. Mavrogenis AF, Galanakos S, Savvidou OD, Papagelopoulos PJ: Adamantinoma of the tibia mimicking a benign cystic lesion: a case report. Clin Podiatr Med Surg; 2010 Jan;27(1):157-65
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  • [Title] Adamantinoma of the tibia mimicking a benign cystic lesion: a case report.
  • Adamantinoma of the long bones is a rare primary malignant bone tumor accounting for less than 1% of all primary malignant bone tumors.
  • Most typical imaging findings include heterogeneous osteolytic cortical lesions showing multiple sharply circumscribed lucent zones of various sizes with sclerotic bone surroundings, interspersing between, and extending above and below the lucent zones by the thinning and bulging cortex.
  • In this article, the authors present a case report of a patient with a distal tibia adamantinoma mimicking a benign cystic lesion.
  • [MeSH-major] Adamantinoma / diagnosis. Bone Cysts / diagnosis. Bone Neoplasms / diagnosis. Tibia
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male

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  • (PMID = 19963177.001).
  • [ISSN] 1558-2302
  • [Journal-full-title] Clinics in podiatric medicine and surgery
  • [ISO-abbreviation] Clin Podiatr Med Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. Bishop JA, Ali SZ: Primary tibial adamantinoma diagnosed by fine needle aspiration. Diagn Cytopathol; 2010 Mar;38(3):198-201
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  • [Title] Primary tibial adamantinoma diagnosed by fine needle aspiration.
  • Adamantinoma is one of the rarest primary bone tumors and is almost exclusively found in the tibia.
  • Because of its scarcity, there are only a handful of reported cases of adamantinoma diagnosed by fine needle aspiration (FNA).
  • We report a case of a 30-year-old woman seen at The Johns Hopkins Hospital for a 2.5-cm lytic lesion in the distal diaphysis of the tibia.
  • A computed tomography-guided FNA of the lesion revealed a moderately cellular lesion consisting of a biphasic admixture of epithelioid cells seen singly and in fragments.
  • An immunostain for cytokeratin was positive, supporting the diagnosis of adamantinoma.
  • Due primarily to its rarity, the diagnosis of adamantinoma on FNA can be challenging and must be made in the context of its characteristic clinical and radiographic setting.
  • [MeSH-major] Adamantinoma / diagnosis. Bone Neoplasms / diagnosis. Tibia / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Biopsy, Fine-Needle. Bone Transplantation. Female. Humans. Immunohistochemistry. Keratins / analysis

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  • (PMID = 19774617.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
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10. Flowers R, Baliga M, Guo M, Liu SS: Tibial adamantinoma with local recurrence and pulmonary metastasis: report of a case with histocytologic findings. Acta Cytol; 2006 Sep-Oct;50(5):567-73
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  • [Title] Tibial adamantinoma with local recurrence and pulmonary metastasis: report of a case with histocytologic findings.
  • BACKGROUND: Adamantinoma is a rare primary bone neoplasm of low malignant potential that may recur or metastasize in a mall percentage of patients.
  • CASE: A 32-year-old man presented with a mass in the distal side of the left leg that was diagnosed as classic adamantinoma by open biopsy.
  • CONCLUSION: The diagnosis of adamantinoma requires knowledge of compatible clinical and radiologic studies as well as understanding of the variable histologic patterns that one may encounter.
  • Fine needle aspiration biopsy is particularly useful in the diagnosis of recurrent and metastatic adamantinoma.
  • This case report describes a distinctive cytomorphologic feature of nuclear grooves that may be a useful aid in distinguishing the tumor cells of adamantinoma from other cell types.
  • [MeSH-major] Adamantinoma / diagnosis. Bone Neoplasms / diagnosis. Lung / pathology. Lung Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis. Tibia / pathology
  • [MeSH-minor] Adult. Amputation. Biomarkers, Tumor / analysis. Biomarkers, Tumor / biosynthesis. Biopsy, Fine-Needle. Cell Shape. Diagnosis, Differential. Disease Progression. Epithelial Cells / pathology. Humans. Magnetic Resonance Imaging. Male. Nuclear Envelope / pathology. Prognosis

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  • (PMID = 17017449.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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11. Kitsoulis P, Mantellos G, Xenakis T: Adamantinoma of the tibia: local resection and distraction osteogenesis. Acta Chir Belg; 2009 Jan-Feb;109(1):126-9
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  • [Title] Adamantinoma of the tibia: local resection and distraction osteogenesis.
  • We describe a case of adamantinoma of the distal tibia in a 31-year-old woman.
  • Segmental resection of the part of the tibia containing the tumour in normal bone was done and the bone defect was bridged with bone transport and external fixation.
  • The tibia healed uneventfully and one year after the operation the patient resumed full activity.
  • [MeSH-major] Adamantinoma / surgery. Bone Neoplasms / surgery. Osteogenesis, Distraction. Tibia

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  • (PMID = 19341216.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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12. Most MJ, Sim FH, Inwards CY: Osteofibrous dysplasia and adamantinoma. J Am Acad Orthop Surg; 2010 Jun;18(6):358-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Osteofibrous dysplasia and adamantinoma.
  • Osteofibrous dysplasia (OFD) is a rare, benign, fibro-osseous lesion that typically is seen within the cortex of the tibia in children.
  • Adamantinoma (AD) is a rare, low-grade malignant primary bone tumor that occurs most often in the tibia and/or fibula of adolescent persons and young adults; however, it has been reported in other long bones, as well.
  • [MeSH-major] Adamantinoma / pathology. Adamantinoma / surgery. Bone Neoplasms / pathology. Bone Neoplasms / surgery. Fibrous Dysplasia of Bone / pathology. Fibrous Dysplasia of Bone / surgery
  • [MeSH-minor] Diagnosis, Differential. Humans. Neoplasm Staging. Prognosis

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  • (PMID = 20511441.001).
  • [ISSN] 1067-151X
  • [Journal-full-title] The Journal of the American Academy of Orthopaedic Surgeons
  • [ISO-abbreviation] J Am Acad Orthop Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 46
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13. Cappuccio M, Montalti M, Bosco G, Gasbarrini A, Boriani S: Unusual radiographic appearance of adamantinoma. Orthopedics; 2009 Dec;32(12):926
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual radiographic appearance of adamantinoma.
  • Adamantinoma is a rare tumor with an indolent course that occurs most commonly in the tibia.
  • Microscopically, adamantinoma consists of islands of epithelial cells in a fibrous stroma.
  • The most common radiographic appearance is that of multiple sharply demarcated radiolucent lesions surrounded by areas of dense, sclerotic bone.
  • This tumor most often affects the tibial diaphysis and produces lytic lesions that can cause fractures.
  • A 31-year-old man presented with a rapidly growing lytic lesion of the distal tibia.
  • Diagnosis of adamantinoma was performed.
  • The lesion was treated with en bloc resection and reconstruction with distal tibia allograft and ankle arthrodesis with retrograde nail.
  • [MeSH-major] Adamantinoma / radiography. Adamantinoma / surgery. Bone Neoplasms / radiography. Bone Neoplasms / surgery. Tibia / radiography. Tibia / surgery

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  • [Copyright] Copyright 2009, SLACK Incorporated.
  • (PMID = 19968233.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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14. Roque P, Mankin HJ, Rosenberg A: Adamantinoma: an unusual bone tumour. Chir Organi Mov; 2008 Dec;92(3):149-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adamantinoma: an unusual bone tumour.
  • Adamantinoma is a rare tumour, which most often affects the tibia and produces lytic and sometimes destructive lesions, which can cause fractures.
  • [MeSH-major] Adamantinoma / pathology. Adamantinoma / radiography. Bone Neoplasms / pathology. Bone Neoplasms / radiography. Tibia / pathology. Tibia / radiography

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  • (PMID = 19030952.001).
  • [ISSN] 1973-2538
  • [Journal-full-title] La Chirurgia degli organi di movimento
  • [ISO-abbreviation] Chir Organi Mov
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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15. Izquierdo FM, Ramos LR, Sánchez-Herráez S, Hernández T, de Alava E, Hazelbag HM: Dedifferentiated classic adamantinoma of the tibia: a report of a case with eventual complete revertant mesenchymal phenotype. Am J Surg Pathol; 2010 Sep;34(9):1388-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dedifferentiated classic adamantinoma of the tibia: a report of a case with eventual complete revertant mesenchymal phenotype.
  • Adamantinomas of the long bones are low-grade malignant tumours.
  • We report a case of an adamantinoma with a revertant sarcomatoid transformation that showed a complete loss of epithelial differentiation.
  • It corresponded to a 41-year-old male presented with an 8-cm multilobated lesion in the centre of the distal tibia.
  • On the en bloc resection specimen, areas of classic adamantinoma were found but most of the tumor corresponded to a high-grade neoplasm with 2 histologic patterns: one made up by epithelial nests with a basaloid arrangement and positive for pankeratins and so-called glandular keratins, and a second sarcomatoid component, negative for these epithelial markers.
  • However, our case represents the extreme end of the sarcomatoid dedifferentiation of a classic adamantinoma with complete sarcomatoid transformation and total loss of epithelial markers.
  • [MeSH-major] Adamantinoma / pathology. Bone Neoplasms / pathology. Sarcoma / pathology. Tibia / pathology

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  • (PMID = 20717000.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Biomarkers, Tumor; 0 / CAM 5.2 antigen; 68238-35-7 / Keratins
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16. Panchwagh Y, Puri A, Agarwal M, Chinoy R, Jambhekar N: Case report: metastatic adamantinoma of the tibia--an unusual presentation. Skeletal Radiol; 2006 Mar;35(3):190-3
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  • [Title] Case report: metastatic adamantinoma of the tibia--an unusual presentation.
  • A 26-year-old female with a tibial lesion diagnosed as an adamantinoma was treated with intra-lesional curettage, bone grafting and intra-medullary nailing.
  • Although cases of local recurrences and pulmonary metastases in adamantinoma are reported, this case is unusual in presenting without a local recurrence but with simultaneous skeletal and pulmonary metastases.
  • [MeSH-major] Adamantinoma / secondary. Bone Neoplasms / pathology. Femoral Neoplasms / secondary. Lung Neoplasms / secondary. Tibia

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  • (PMID = 16402219.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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17. Mavrogenis AF, Sakellariou VI, Tsibidakis H, Papagelopoulos PJ: Adamantinoma of the tibia treated with a new intramedullary diaphyseal segmental defect implant. J Int Med Res; 2009 Jul-Aug;37(4):1238-45

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adamantinoma of the tibia treated with a new intramedullary diaphyseal segmental defect implant.
  • In this case report, a 75-year old male presented with a mass on the anterior surface of the mid-shaft of the right tibia.
  • Imaging studies showed a well-circumscribed radiolucent lesion in the anterior tibial cortex, without soft tissue extension.
  • Histological diagnosis was consistent with adamantinoma, a rare primary bone tumour.
  • Wide tumour resection of approximately 16 cm of the tibial diaphysis with a surrounding cuff of normal tissue was performed.
  • The bone defect was reconstructed using an intramedullary diaphyseal segmental defect fixation system.
  • [MeSH-major] Adamantinoma / pathology. Adamantinoma / surgery. Limb Salvage / methods. Tibia / pathology. Tibia / surgery

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  • (PMID = 19761710.001).
  • [ISSN] 0300-0605
  • [Journal-full-title] The Journal of international medical research
  • [ISO-abbreviation] J. Int. Med. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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18. Frey SP, Hardes J, Ahrens H, Winkelmann W, Gosheger G: Total tibia replacement using an allograft (in a patient with adamantinoma). Case report and review of literature. J Cancer Res Clin Oncol; 2008 Apr;134(4):427-31

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Total tibia replacement using an allograft (in a patient with adamantinoma). Case report and review of literature.
  • INTRODUCTION: Adamantinoma is a very rare, low-grade, malignant bone tumour that accounts for approximately 0.4% of all primary bone tumours.
  • Radiographically, adamantinomas vary in length, have a clearly defined outline, with a bubbly appearance and increase the width of the bone.
  • CASE PRESENTATION: We present a case of adamantinoma of the tibia, in which a resection of the whole tibia and reconstruction with a total tibia allograft was necessary.
  • DISCUSSION: The histological diagnosis is sophisticated.
  • It is often difficult to distinguish an adamantinoma from other tumours.
  • The most frequent described method to treat adamantinoma is wide resection and the use of an allograft.
  • CONCLUSION: A total tibia allograft as presented in our case is not described in the literature.
  • Using a prosthesis system instead of the allograft might have saved the limb of our patient.
  • [MeSH-major] Adamantinoma / surgery. Tibia / surgery

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  • (PMID = 18060426.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 16
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19. Napp M, Stengel BA, Buschmann J, Döhler JR: [Osteofibrous dysplasia campanacci of the tibia. A 12-year follow-up]. Chirurg; 2009 Mar;80(3):241-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Osteofibrous dysplasia campanacci of the tibia. A 12-year follow-up].
  • [Transliterated title] Osteofibröse Dysplasie Campanacci der Tibia : Ein 12-Jahres-Follow-up.
  • This article concerns a rare tumor-like lesion primarily in the tibial diaphysis in young patients.
  • The case is presented of a girl with stress fracture, distinct antecurvation, relapse, and refracture.
  • Despite the controversial indication, we recommend this method due to the disorder's putative relationship with malignant adamantinoma.
  • [MeSH-major] Fibrous Dysplasia of Bone / surgery. Fractures, Spontaneous / surgery. Tibial Fractures / surgery
  • [MeSH-minor] Bone Transplantation. Child. Diagnosis, Differential. Female. Follow-Up Studies. Fracture Fixation, Internal / methods. Fracture Healing / physiology. Humans. Osteoblasts / pathology. Postoperative Complications / pathology. Postoperative Complications / radiography. Postoperative Complications / surgery. Recurrence. Tibia / pathology. Tibia / surgery

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  • (PMID = 18690418.001).
  • [ISSN] 1433-0385
  • [Journal-full-title] Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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20. Van Rijn R, Bras J, Schaap G, van den Berg H, Maas M: Adamantinoma in childhood: report of six cases and review of the literature. Pediatr Radiol; 2006 Oct;36(10):1068-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adamantinoma in childhood: report of six cases and review of the literature.
  • BACKGROUND: Adamantinoma is a rare slow-growing malignant bone tumour.
  • MATERIALS AND METHODS: The database of the Working Group on Paediatric Oncology, Academic Medical Centre/Emma Children's Hospital Amsterdam, was searched for cases of adamantinoma.
  • Additionally a literature study was performed to identify cases of adamantinoma in childhood.
  • RESULTS: We identified six local cases of adamantinoma of the long bones, two boys (age 3 and 8 years) and four girls (mean age 8.8 years, range 3.0-14.0 years).
  • The location of the tumour was the tibia in five and the tibia and fibula in one patient.
  • In two patients initially a different diagnosis was made, which led to a delay in appropriate treatment.
  • CONCLUSION: Although the incidence of adamantinoma is low, it is important to recognize this rare bone tumour, since in the early stages of the disease adequate treatment will result in an excellent prognosis.
  • [MeSH-major] Adamantinoma / diagnosis
  • [MeSH-minor] Adolescent. Child. Diagnosis, Differential. Female. Humans. Leg. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 16906392.001).
  • [ISSN] 0301-0449
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 59
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21. Al-Daraji WI, Al-Daraji UW, Al-Mahmoud RM: Adamantinoma associated with botryomycosis: the first report of this rare association after trauma. Clin Exp Dermatol; 2008 Jul;33(4):433-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adamantinoma associated with botryomycosis: the first report of this rare association after trauma.
  • A 27-year-old man presented with swelling and inflammation of his right tibia, which had been present for nearly 3 years.
  • The right tibia was swollen to twice the size of the left and the skin was indurated with numerous crusted lesions and some sinus-like areas, but no ulceration of the skin surface was apparent.
  • We report for the first time to our knowledge a unique case of both botryomycosis and adamantinoma in the right tibia of the same patient at an area of previous trauma.
  • Although both botryomycosis and adamantinoma usually have a history of trauma, as in our patient, a causal relationship will need more cases to establish a possible link.
  • [MeSH-major] Adamantinoma / complications. Granulomatous Disease, Chronic / complications. Staphylococcal Skin Infections / complications. Tibia. Wounds, Nonpenetrating / complications

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  • (PMID = 18312455.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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22. Mathew M, Joseph B: Differentiated adamantinoma: a case report and review of literature. Indian J Pathol Microbiol; 2007 Jul;50(3):565-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differentiated adamantinoma: a case report and review of literature.
  • Adamantinoma of the long bones are uncommon, slow growing tumors with a predilection for the tibia.
  • A special rare variant known as the osteofibrous dysplasia-like adamantinoma or differentiated adamantinoma is thought to be a precursor of the classic adamantinoma.
  • We report a case in a 24 year old female who presented with pain and lytic lesion of the left tibia.
  • [MeSH-major] Adamantinoma / diagnosis. Bone Neoplasms / diagnosis. Tibia / pathology
  • [MeSH-minor] Adult. Female. Fibrous Dysplasia of Bone / pathology. Humans

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  • (PMID = 17883137.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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23. Gleason BC, Liegl-Atzwanger B, Kozakewich HP, Connolly S, Gebhardt MC, Fletcher JA, Perez-Atayde AR: Osteofibrous dysplasia and adamantinoma in children and adolescents: a clinicopathologic reappraisal. Am J Surg Pathol; 2008 Mar;32(3):363-76
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Osteofibrous dysplasia and adamantinoma in children and adolescents: a clinicopathologic reappraisal.
  • Osteofibrous dysplasia (OFD) and adamantinoma are rare and most commonly arise in the tibia of young individuals.
  • Although OFD has typical histopathologic features, areas resembling OFD have often been noted at the periphery of otherwise classic adamantinomas, and some have suggested that OFD may be either a precursor to or a regressive phase of adamantinoma.
  • The so-called OFD-like adamantinoma encompasses some features of both OFD and adamantinoma.
  • We studied the clinical, imaging, histopathologic, immunohistochemical, ultrastructural, and molecular features of 16 OFD and 8 adamantinomas (5 OFD-like and 3 classic) in an attempt to further define their morphology, clinical course, and relationship.
  • Patients with OFD were generally younger than those with adamantinoma.
  • Osteoblastic and osteoclastic activity was more prominent in OFD than in OFD-like adamantinoma.
  • In addition to the inconspicuous small clusters of epithelial cells in OFD-like adamantinoma, isolated keratin-positive cells with a unique ultrastructural hybrid fibroblastic-epithelial phenotype were found in the stroma of all OFD and OFD-like adamantinomas.
  • Fluorescence in situ hybridization analysis revealed trisomies 7, 8, and/or 12 in the spindle cell stroma of OFD, OFD-like, and classic adamantinoma, supporting a neoplastic origin of OFD and a common histogenesis for all 3 lesions.
  • Of the 11 OFD patients with follow-up (median, 4.5 y), all 3 who underwent incisional biopsy had persistent, nonprogressive disease and 2 of 8 who underwent curettage or wide excision had recurrence; none developed adamantinoma.
  • All 6 adamantinoma patients with follow-up (3 classic and 3 OFD-like) were treated with wide excision.
  • One with classic adamantinoma died of pulmonary metastases 9 years after presentation; the other 5 were free of disease with a median follow-up of 12 years.
  • None of the classic adamantinomas evolved into OFD-like adamantinoma or OFD.
  • Although the histopathology, immunohistochemistry, ultrastructure, and cytogenetics indicate that these lesions are closely related, our data and the literature suggest that only classic adamantinoma has malignant potential.
  • OFD, OFD-like adamantinoma, and classic adamantinoma appear to show a progressive complexity of cytogenetic aberrations, perhaps indicative of a multistep neoplastic transformation.
  • [MeSH-major] Adamantinoma / pathology. Bone Neoplasms / pathology. Fibrous Dysplasia of Bone / pathology

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  • (PMID = 18300815.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Makhson AN, Bulycheva IV, Kuz'min IV, Pavlenko TV: [Adamantinoma of long tubal bones]. Arkh Patol; 2006 Jan-Feb;68(1):14-8

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  • [Title] [Adamantinoma of long tubal bones].
  • Four cases of adamantinomas of the long tubular bones, ulna and femur among them which rarely occur in patients aged 18-64 years (one female) are reported.
  • Immunohistochemistry helps in differential diagnosis of this tumor.
  • [MeSH-major] Adamantinoma / ultrastructure. Femoral Neoplasms / ultrastructure. Tibia / ultrastructure

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  • (PMID = 16544529.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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25. Piña-Oviedo S, Del Valle L, Padilla-Longoria R, Mendoza-Ramón H, Ortiz-Hidalgo C: Primary adamantinoma of the rib. Unusual presentation for a bone neoplasm of uncertain origin. Pathol Oncol Res; 2008 Dec;14(4):497-502
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary adamantinoma of the rib. Unusual presentation for a bone neoplasm of uncertain origin.
  • Adamantinomas are rare, low-grade malignant intra-osseous tumors composed of epithelial and mesenchymal elements, which show a marked predilection for the tibia and fibula of young adult male patients.
  • Although cases of adamantinoma located to the axial skeleton have been reported either as recurrent or metastatic disease, only two cases of primary adamantinoma located to the thoracic wall have been previously described.
  • In this study we present the clinical, radiological and histopathological features of a 24-year-old male with a slow growing, solid-cystic, painful mass, located to the right 11th rib, which was morphological and immunohistochemically diagnosed as a primary classic adamantinoma.
  • [MeSH-major] Adamantinoma / pathology. Ribs / pathology

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  • (PMID = 18409022.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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26. Szendroi M, Antal I, Arató G: Adamantinoma of long bones: a long-term follow-up study of 11 cases. Pathol Oncol Res; 2009 Jun;15(2):209-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adamantinoma of long bones: a long-term follow-up study of 11 cases.
  • The aim of this study was to evaluate the clinicopathological features and prognostic significances of 11 histologically proven adamantinoma cases based on an average 12,7 year long follow-up.
  • The initial diagnosis at referral was other than adamantinoma in six patients (fibrous dysplasia, carcinoma metastasis, osteofibrous dysplasia, bone cyst, non-ossifying fibroma), referring to the differential diagnostic problems.
  • All tumors were localized to the mid part of tibia.
  • All adamantinoma were positive for cytokeratins often in coexpression with vimentin.
  • Adamantinoma of the long bones is a low grade malignant tumor, which clinical outcome is difficult to predict based on histology or surgical stage of the tumor.
  • This study underlines that recurrences do occur even decades after recognition the tumor, therefore a life-long follow-up of the patient is necessary.
  • [MeSH-major] Adamantinoma / pathology. Bone Neoplasms / pathology. Tibia
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / surgery. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Prognosis. Survival Rate. Young Adult

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  • (PMID = 19048403.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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27. Khanna M, Delaney D, Tirabosco R, Saifuddin A: Osteofibrous dysplasia, osteofibrous dysplasia-like adamantinoma and adamantinoma: correlation of radiological imaging features with surgical histology and assessment of the use of radiology in contributing to needle biopsy diagnosis. Skeletal Radiol; 2008 Dec;37(12):1077-84

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Osteofibrous dysplasia, osteofibrous dysplasia-like adamantinoma and adamantinoma: correlation of radiological imaging features with surgical histology and assessment of the use of radiology in contributing to needle biopsy diagnosis.
  • OBJECTIVES: The aim of this study was to correlate the imaging features with surgical histology for tibial osteofibrous dysplasia (OFD), osteofibrous dysplasia-like adamantinoma (OFD/LA) and classical adamantinoma and to determine the additional role of imaging in suggesting a correct diagnosis in cases of needle biopsy misdiagnosis.
  • The needle biopsy diagnosis and resection specimen histological diagnoses were retrospectively reviewed and compared with the imaging findings.
  • RESULTS: The 24 cases comprised five OFD, 11 OFD/LA and eight adamantinoma based on surgical resection histology.
  • The mean length of OFD was 6.1 cm (range 2-8.5 cm), for OFD/LA was 6.5 cm (range 2-13 cm) and for adamantinoma was 13.2 cm (range 6.5-26 cm).
  • Four of 19 cases had a different needle biopsy result compared to the final histology, three cases being upgraded from an OFD/LA or OFD to classical adamantinoma.
  • The radiological features of these three cases were more in keeping with a diagnosis of adamantinoma.
  • CONCLUSIONS: A diagnosis of classical adamantinoma is suggested by an extensive lesion with moth-eaten margins and complete involvement of the medullary cavity on axial MR imaging.
  • Misdiagnosis on needle biopsy may occur in up to one fifth of cases, and radiological features can assist in making the correct diagnosis.
  • [MeSH-major] Adamantinoma / diagnosis. Adamantinoma / surgery. Fibrous Dysplasia of Bone / diagnosis. Fibrous Dysplasia of Bone / surgery
  • [MeSH-minor] Adolescent. Adult. Biopsy, Needle. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Middle Aged. Observer Variation. Retrospective Studies. Tibia / pathology. Tibia / radiography. Tibia / surgery. Young Adult

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  • (PMID = 18690429.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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28. Chandrasekar CR, Mohammed R, Rafalla AA, Grimer RJ: Adamantinoma of the calcaneum--a case report. Foot (Edinb); 2009 Mar;19(1):58-61
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  • [Title] Adamantinoma of the calcaneum--a case report.
  • Adamantinoma is rare, representing less than 1% of all primary malignant bone tumours.
  • It is a slow growing low grade malignant tumour which is often clinically, radiologically and histologically mistaken for many other tumours like Ewing's sarcoma, synovial sarcoma, fibrosarcoma, metastatic carcinoma, fibrous cortical defect and osteofibrous dysplasia.
  • Adamantinoma commonly occurs in the tibia.
  • Adamantinoma of the foot is extremely rare.
  • There are few reported cases of metatarsal and cuneiform bone involvement.
  • To our knowledge adamantinoma of the calcaneum has not been previously reported in the literature.
  • We report the case of a male patient, aged 33 years, who was treated for adamantinoma of the calcaneum and followed for 16 years highlighting the difficulty in diagnosis and management of this rare tumor occurring at a rare site.
  • [MeSH-major] Adamantinoma / pathology. Bone Neoplasms / pathology. Calcaneus / pathology

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  • (PMID = 20307451.001).
  • [ISSN] 1532-2963
  • [Journal-full-title] Foot (Edinburgh, Scotland)
  • [ISO-abbreviation] Foot (Edinb)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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29. Fujii H, Honoki K, Enomoto Y, Kasai T, Kido A, Amano I, Kumamoto M, Morishita T, Mii Y, Nonomura A, Takakura Y: Adamantinoma-like Ewing's sarcoma with EWS-FLI1 fusion gene: a case report. Virchows Arch; 2006 Nov;449(5):579-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adamantinoma-like Ewing's sarcoma with EWS-FLI1 fusion gene: a case report.
  • Recent studies have advocated the genotypic and phenotypic delineation of a novel Ewing's sarcoma histologic variant showing epithelial features defined as "adamantinoma-like Ewing's sarcoma".
  • We described an 18-year-old girl with a primary small round-cell sarcoma of the right tibia showing polyphenotypic differentiation with epithelioid features.
  • The diagnosis of the lesion was confirmed as Ewing's sarcoma by the presence of the EWS-FLI1 fusion transcript, and could be defined as the so-called "adamantinoma-like Ewing's sarcoma".
  • After wide excision and high-dose chemotherapy with peripheral blood stem cell transfusion, the patient has been well and continuously event-free for 3 years since the initial diagnosis.
  • [MeSH-major] Adamantinoma / pathology. Bone Neoplasms / pathology. Oncogene Proteins, Fusion / genetics. Proto-Oncogene Protein c-fli-1 / genetics. Sarcoma, Ewing / pathology

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  • (PMID = 17016721.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / EWS-FLI fusion protein; 0 / Oncogene Proteins, Fusion; 0 / Proto-Oncogene Protein c-fli-1; 0 / RNA-Binding Protein EWS
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30. Zamzam MM: Congenital osteofibrous dysplasia of the tibia, associated with pseudoarthrosis of the ipsilateral fibula. Saudi Med J; 2008 Oct;29(10):1507-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Congenital osteofibrous dysplasia of the tibia, associated with pseudoarthrosis of the ipsilateral fibula.
  • We describe an otherwise normal male neonate who presented shortly after birth with rare congenital osteofibrous dysplasia of the right tibia associated with pseudoarthrosis of the ipsilateral fibula.
  • The lesion was curetted, and the defect was packed with a fibular bone graft from the other leg.
  • The case is a new presentation of congenital osteofibrous dysplasia, and is presented to draw attention to this rare condition that must be considered in the differential diagnosis of congenital lesions of the tibia.
  • [MeSH-major] Bone Neoplasms / congenital. Fibroma, Ossifying / congenital. Fibula. Pseudarthrosis / congenital. Tibia
  • [MeSH-minor] Adamantinoma / pathology. Bone Transplantation. Diagnosis, Differential. Fibrous Dysplasia, Monostotic / pathology. Humans. Infant, Newborn. Magnetic Resonance Imaging. Male

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  • (PMID = 18946584.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Saudi Arabia
  • [Number-of-references] 14
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31. Ramseier LE, Malinin TI, Temple HT, Mnaymneh WA, Exner GU: Allograft reconstruction for bone sarcoma of the tibia in the growing child. J Bone Joint Surg Br; 2006 Jan;88(1):95-9
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  • [Title] Allograft reconstruction for bone sarcoma of the tibia in the growing child.
  • The outcome of tibial allograft reconstruction after resection of a tumour is inconsistent and has a high rate of failure.
  • There are few reports on the use of tibial allografts in children with open growth plates.
  • Two had Ewing's sarcoma, one an adamantinoma and 16 osteosarcoma, one with multifocal disease.
  • Although our results remain inconsistent, tibial allograft reconstruction in selected patients may restore complete and durable function of the limb.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Transplantation / methods. Osteosarcoma / surgery. Tibia / surgery
  • [MeSH-minor] Adamantinoma / surgery. Adolescent. Child. Female. Follow-Up Studies. Humans. Leg Length Inequality / etiology. Male. Reoperation / methods. Sarcoma, Ewing / surgery. Treatment Outcome. Wound Healing

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  • (PMID = 16365128.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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32. Almeida Herrero F, Silvestre Muñoz A, Martinez Rodriguez M, Gomar Sancho F: Ossifying fibroma of long bones in adults: a case report. Acta Orthop Belg; 2006 Dec;72(6):786-9
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  • [Title] Ossifying fibroma of long bones in adults: a case report.
  • Ossifying fibroma (osteofibrous dysplasia) is a rare fibro-osseous lesion made up of fibrous tissue with woven bone formation.
  • It is most commonly found in the tibia and fibula of children ten years of age or younger.
  • The most important differential diagnosis is monostotic fibrous dysplasia, which is radiologically similar but without woven bone rimmed by active osteoblasts like ossifying fibroma on histological examination.
  • No epitheloid cells are found as in adamantinoma.
  • We report the case of a 45-year-old woman who had a 12-month history of pain and slight swelling.
  • Radiographs showed a multilocular radiolucent lesion with sclerotic rim in the proximal tibia.
  • The lesion was curetted and the defect was packed with bone graft and acrylic cement.
  • Microscopic examination showed active osteoblasts rimming the irregulary woven bone.
  • [MeSH-major] Bone Neoplasms / diagnosis. Fibroma, Ossifying / diagnosis. Tibia
  • [MeSH-minor] Bone Substitutes / therapeutic use. Curettage. Female. Humans. Middle Aged

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  • (PMID = 17260623.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Bone Substitutes
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33. Ulmar B, Delling G, Werner M, Huch K, Reichel H: Classical and atypical location of adamantinomas--presentation of two cases. Onkologie; 2006 Jun;29(6):276-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Adamantinomas are rare low-grade primary bone tumors of unknown histological origin.
  • They typically develop in the diaphyses and metaphyses of long bones, prevalently the tibia.
  • CASE REPORTS: The cases of 2 female patients, one with localized swelling of the lateral metatarsals and one with pain of the tibia are being reported.
  • The diagnostic work-up including biopsy verified an adamantinoma in both cases.
  • In the younger patient, the tumor was located in the metatarsals 4 and 5, in the older patient in the left tibial diaphyses.
  • CONCLUSION: Adamantinomas of the short bones are rarely reported.
  • [MeSH-major] Adamantinoma / diagnosis. Adamantinoma / surgery. Bone Neoplasms / diagnosis. Bone Neoplasms / surgery. Metatarsal Bones / surgery. Tibia / surgery
  • [MeSH-minor] Adolescent. Female. Humans. Middle Aged. Rare Diseases / diagnosis. Rare Diseases / surgery

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  • (PMID = 16783903.001).
  • [ISSN] 0378-584X
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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34. Park YK, Ryu KN, Han CS: Synchronous intracortical adamantinomas with keratin cyst formation. Skeletal Radiol; 2006 Mar;35(3):185-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Adamantinoma of the long bones is a rare primary bone tumor of uncertain embryogenesis.
  • It tends to involve the tibia almost exclusively.
  • We report on adamantinomas occurring in a 16-year-old male patient, with synchronous tibial and fibular lesions.
  • This keratin cyst formation is quite an unusual finding in classic adamantinoma.
  • [MeSH-major] Adamantinoma / diagnosis. Bone Cysts / diagnosis. Bone Neoplasms / diagnosis. Fibula / pathology. Keratins / analysis. Magnetic Resonance Imaging. Tibia / pathology
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Humans. Male. Neoplasms, Multiple Primary

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  • (PMID = 16217667.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 68238-35-7 / Keratins
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35. Hahn SB, Kim SH, Cho NH, Choi CJ, Kim BS, Kang HJ: Treatment of osteofibrous dysplasia and associated lesions. Yonsei Med J; 2007 Jun 30;48(3):502-10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: To report long term treatment outcomes of osteofibrous dysplasia and association with adamantinoma.
  • RESULTS: Thirteen patients had a lesion in the tibia, while one patient had lesions in both the tibia and the fibula.
  • Initial treatments were observation after biopsy (6 patients), curettage with or without a bone graft (3 patients), resection followed by a free vascularized fibular bone graft (4 patients), or resection and regeneration with the Ilizarov external fixation (1 patient).
  • After the initial pathology slides of the 13 patients were reviewed with immunohistochemical cytokeratin staining, one patient diagnosis was changed from osteofibrous dysplasia to osteofibrous dysplasia-like adamantinoma.
  • CONCLUSION: Some patients with osteofibrous dysplasia require close observation because of the high association risk between osteofibrous dysplasia and adamantinoma, Immunohistochemical staining may be helpful in differentiating these two diagnoses.
  • [MeSH-major] Adamantinoma / surgery. Fibrous Dysplasia of Bone / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Fibula / chemistry. Fibula / radiography. Fibula / surgery. Humans. Immunohistochemistry. Keratins / analysis. Male. Middle Aged. Tibia / chemistry. Tibia / radiography. Tibia / surgery

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  • [Cites] J Bone Joint Surg Am. 1981 Mar;63(3):483-8 [7204453.001]
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  • (PMID = 17594160.001).
  • [ISSN] 0513-5796
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 68238-35-7 / Keratins
  • [Other-IDs] NLM/ PMC2628088
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36. Weber K, Damron TA, Frassica FJ, Sim FH: Malignant bone tumors. Instr Course Lect; 2008;57:673-88
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant bone tumors.
  • Malignant bone tumors represent a small percentage of cancers nationwide and also are much less common than malignant soft-tissue tumors.
  • The most common primary malignant bone tumors, osteosarcoma and Ewing's sarcoma, occur in childhood.
  • Rare tumors such as chordoma and adamantinoma have anatomic predilections for the sacrum and tibia, respectively.
  • The primary symptom of a patient with a malignant bone tumor is pain, which often occurs at rest or at night.
  • Patients with a likely malignancy require thorough staging to determine the extent of disease and a well-planned biopsy for accurate diagnosis.
  • Knowledge of specific tumor characteristics and treatment options for osteosarcoma, Ewing's sarcoma, chondrosarcoma, malignant fibrous histiocytoma, chordoma, and adamantinoma is important.
  • Secondary sarcomas can occur in previously benign bone lesions and require aggressive treatment.
  • Specific techniques are available for the resection of malignant bone tumors from the upper extremities, lower extremities, pelvis, and spine.
  • The care of patients with primary malignant bone tumors requires a multidisciplinary approach to treatment.
  • The orthopaedic oncologist is a vital member of a team composed of musculoskeletal radiologists and pathologists, radiation oncologists, medical and pediatric oncologists, and microvascular surgeons.
  • [MeSH-major] Bone Neoplasms. Orthopedic Procedures / methods
  • [MeSH-minor] Global Health. Humans. Morbidity. Neoplasm Staging / methods. Prognosis

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  • (PMID = 18399615.001).
  • [ISSN] 0065-6895
  • [Journal-full-title] Instructional course lectures
  • [ISO-abbreviation] Instr Course Lect
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 42
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37. Sakellariou VI, Mavrogenis AF, Papagelopoulos PJ: Limb salvage surgery using the intramedullary diaphyseal segmental defect fixation system. J Long Term Eff Med Implants; 2008;18(1):59-67
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Limb salvage surgery using the intramedullary diaphyseal segmental defect fixation system.
  • Six patients underwent segmental bone resection and limb salvage surgery for primary or metastatic bone tumors involving the diaphysis of the femur, the tibia, and the humerus using a modular intramedullary diaphyseal segmental defect fixation system.
  • Histological diagnosis included adamantinoma, synovial sarcoma, multiple myeloma, metastatic renal cell carcinoma, myeloid carcinoma of the thyroid gland, and adenocarcinoma of the stomach.
  • The intramedullary diaphyseal segmental defect fixation system used herein is associated with a satisfactory functional and oncological outcome after wide resection of diaphyseal bone tumors.
  • [MeSH-major] Bone Neoplasms / surgery. Fracture Fixation, Intramedullary / methods. Internal Fixators. Limb Salvage / instrumentation. Limb Salvage / methods. Prosthesis Implantation / instrumentation. Prosthesis Implantation / methods

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  • (PMID = 19348612.001).
  • [ISSN] 1050-6934
  • [Journal-full-title] Journal of long-term effects of medical implants
  • [ISO-abbreviation] J Long Term Eff Med Implants
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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38. Choi E, Wert M, Guerrieri C, Tucci J: A pathologic fracture of an intracortical chondroma masking as an osteoid osteoma. Orthopedics; 2010 Nov;33(11):845
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The differential diagnosis of a tibial intracortical diaphyseal lesion includes osteoid osteoma, periosteal chondroma, nonossifying fibroma, osteofibrous dysplasia, and adamantinoma.
  • While osteoid osteomas represent 5% of all primary bone tumors, little is understood about intracortical chondromas.
  • This article presents the first reported case of a pathologic fracture of an intracortical lesion in a child that shared radiographic and clinical features similar to those of osteoid osteoma, but on histopathologic examination revealed an intracortical chondroma.
  • Our patient exhibited radiographic features of a poorly circumscribed cortical bone sclerosis, a centralized radiolucent nidus on computed tomography, and a hot bone scan of a lesion <1 cm in size that was consistent with an osteoid osteoma.
  • An excision of the bone lesion was performed.
  • The histopathology of the lesion revealed nodules of benign hyaline cartilage in cortical bone, consistent with an intracortical chondroma.
  • Demarcated by cortical bone with mature Haversian systems rather than periosteum or cancellous bone, intracortical chondroma differs from the other 2 chondroma variants, periosteal chondroma and enchondroma, by its relationship to the surrounding bone.
  • [MeSH-major] Bone Neoplasms / diagnosis. Chondroma / diagnosis. Osteoma, Osteoid / diagnosis. Tibial Fractures / pathology
  • [MeSH-minor] Child. Diagnosis, Differential. Humans. Male. Radionuclide Imaging. Tibia / pathology. Tomography, X-Ray Computed. Treatment Outcome

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  • [Copyright] Copyright 2010, SLACK Incorporated.
  • (PMID = 21053879.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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39. Kiral A, Pehlivan O, Cilli F, Akmaz I, Rodop O, Solakoglu C: Reconstruction of intercalary gap after wide surgical resection of adamantinoma of the tibia. Orthopedics; 2008 Nov;31(11):1143
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reconstruction of intercalary gap after wide surgical resection of adamantinoma of the tibia.
  • [MeSH-major] Adamantinoma / surgery. Bone Neoplasms / surgery. Bone Transplantation. Limb Salvage / methods. Tibia / surgery

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  • (PMID = 19226080.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Hoshi M, Matsumoto S, Manabe J, Tanizawa T, Shigemitsu T, Izawa N, Shi X, Kawaguchi N: Surgical treatment for adamantinoma arising from the tibia. J Orthop Sci; 2005 Nov;10(6):665-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment for adamantinoma arising from the tibia.
  • [MeSH-major] Adamantinoma / surgery. Bone Neoplasms / surgery. Tibia

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  • (PMID = 16307196.001).
  • [ISSN] 0949-2658
  • [Journal-full-title] Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
  • [ISO-abbreviation] J Orthop Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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41. Camp MD, Tompkins RK, Spanier SS, Bridge JA, Bush CH: Best cases from the AFIP: Adamantinoma of the tibia and fibula with cytogenetic analysis. Radiographics; 2008 Jul-Aug;28(4):1215-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Best cases from the AFIP: Adamantinoma of the tibia and fibula with cytogenetic analysis.
  • [MeSH-major] Adamantinoma / diagnosis. Chromosome Aberrations. Fibula / pathology. Fibula / radiography. Tibia / pathology. Tibia / radiography

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  • (PMID = 18635638.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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42. Grimer RJ, Carter SR, Tillman RM, Abudu A: Osteofibrous dysplasia of the tibia. J Bone Joint Surg Br; 2007 Jan;89(1):141

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Osteofibrous dysplasia of the tibia.
  • [MeSH-major] Fibrous Dysplasia of Bone / surgery. Tibia / surgery
  • [MeSH-minor] Adamantinoma / diagnosis. Diagnosis, Differential. Humans. Prognosis

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  • [CommentOn] J Bone Joint Surg Br. 2006 May;88(5):658-64 [16645116.001]
  • (PMID = 17259434.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] England
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43. Papagelopoulos PJ, Mavrogenis AF, Galanis EC, Savvidou OD, Inwards CY, Sim FH: Clinicopathological features, diagnosis, and treatment of adamantinoma of the long bones. Orthopedics; 2007 Mar;30(3):211-5; quiz 216-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathological features, diagnosis, and treatment of adamantinoma of the long bones.
  • [MeSH-major] Adamantinoma / diagnosis. Adamantinoma / therapy. Bone Neoplasms / diagnosis. Bone Neoplasms / therapy. Tibia / pathology
  • [MeSH-minor] Diagnosis, Differential. Fibroma / diagnosis. Fibrous Dysplasia of Bone / diagnosis. Hemangioendothelioma / diagnosis. Hemangiosarcoma / diagnosis. Humans. Prognosis. Survival Rate

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  • (PMID = 17375547.001).
  • [ISSN] 0147-7447
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Review
  • [Publication-country] United States
  • [Number-of-references] 57
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44. Khan MH, Darji R, Rao U, McGough R: Leg pain and swelling in a 22-year-old man. Clin Orthop Relat Res; 2006 Jul;448:259-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adamantinoma / diagnosis. Edema / etiology. Leg. Pain / etiology
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Tibia / pathology. Tibia / radiography. Tomography, X-Ray Computed

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  • (PMID = 16826129.001).
  • [ISSN] 0009-921X
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Clinical Conference; Journal Article
  • [Publication-country] United States
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45. Alemdaroğlu KB, Iltar S, Pulat H, Atlihan D: Intermittent leg pain and swelling in a 30-year-old man. Clin Orthop Relat Res; 2007 Sep;462:248-54
Hazardous Substances Data Bank. ALBENDAZOLE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Echinococcosis / diagnosis. Edema / diagnosis. Leg. Pain / diagnosis
  • [MeSH-minor] Adamantinoma / diagnosis. Adult. Albendazole / therapeutic use. Animals. Anticestodal Agents / therapeutic use. Bone Neoplasms / diagnosis. Diagnosis, Differential. Fibroma, Desmoplastic / diagnosis. Fibrous Dysplasia of Bone / diagnosis. Humans. Male. Sarcoma, Ewing / diagnosis. Spleen / parasitology. Spleen / pathology. Spleen / surgery. Taenia / cytology. Taenia / isolation & purification. Tibia / parasitology. Tibia / pathology. Tibia / radiography. Tomography, X-Ray Computed. Treatment Outcome

  • MedlinePlus Health Information. consumer health - Edema.
  • MedlinePlus Health Information. consumer health - Pain.
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  • (PMID = 17308475.001).
  • [ISSN] 0009-921X
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticestodal Agents; F4216019LN / Albendazole
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