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1. Koral K, Weprin B, Rollins NK: Sphenoid sinus craniopharyngioma simulating mucocele. Acta Radiol; 2006 Jun;47(5):494-6
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  • [Title] Sphenoid sinus craniopharyngioma simulating mucocele.
  • We present a case of extracranial craniopharyngioma simulating a sphenoid sinus mucocele in a 12-year-old female who presented with progressive subacute left-sided visual disturbance.
  • Although infrasellar craniopharyngioma is a rare entity, the presence of foci of calcification within the lesion is a useful finding for diagnosis.
  • [MeSH-major] Craniopharyngioma / diagnosis. Mucocele / diagnosis. Pituitary Neoplasms / diagnosis. Sphenoid Sinus
  • [MeSH-minor] Child. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 16796313.001).
  • [ISSN] 0284-1851
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
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2. Yan Y, Tang WY, Yang G, Zhong D: Isolated cerebellopontine angle craniopharyngioma. J Clin Neurosci; 2009 Dec;16(12):1655-7
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  • [Title] Isolated cerebellopontine angle craniopharyngioma.
  • Primary cerebellopontine angle craniopharyngioma is rare; only 5 surgically treated patients have been reported.
  • We report a 54-year-old female with craniopharyngioma occurring in isolation in the cerebellopontine angle and compare this patient with previously published reports.
  • The origin of and surgical strategy for such tumors are discussed.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellopontine Angle / pathology. Craniopharyngioma / pathology

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  • (PMID = 19773170.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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3. Mohanty S, Balakrishnan S: Management of extra sellar craniopharyngioma masquerading as hypertrophied adenoid tissue in a 6-year-old boy. Int J Pediatr Otorhinolaryngol; 2008 Sep;72(9):1441-4
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  • [Title] Management of extra sellar craniopharyngioma masquerading as hypertrophied adenoid tissue in a 6-year-old boy.
  • Described here is a rare case of a craniopharyngioma of the nasopharynx and the sphenoid sinus and its surgical resection via an endoscopic, transnasal, transphenoidal approach.
  • Craniopharyngiomas are histologically benign, extra-axial slow growing tumours of the sellar and the supra sellar space.
  • Possibility of the occurrence of such rare tumours needs to be always kept in mind while dealing with nasopharyngeal masses.
  • Long term follow up of these patients is mandatory, because of the tendency of craniopharyngioma's to recur.
  • Here, the patient was a 10-year-old boy, who had none of the above symptoms and was operated upon previously for the same complaints, with no relief in symptoms.
  • [MeSH-major] Craniopharyngioma / diagnosis. Nasopharyngeal Neoplasms / diagnosis. Paranasal Sinus Neoplasms / diagnosis. Sphenoid Sinus
  • [MeSH-minor] Adenoidectomy. Adenoids / pathology. Child. Diagnosis, Differential. Endoscopy. Humans. Male

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  • (PMID = 18620758.001).
  • [ISSN] 0165-5876
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
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4. Rudnik A, Zawadzki T, Wojtacha M, Bazowski P, Gamrot J, Galuszka-Ignasiak B, Duda I: Endoscopic transnasal transsphenoidal treatment of pathology of the sellar region. Minim Invasive Neurosurg; 2005 Apr;48(2):101-7
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  • In 63 cases the operation was done because of pituitary gland adenomas.
  • In one case the diagnosis was craniopharyngioma, in 1 chordoma of the clivus, in one glioma of the optic nerve, in 1 the reason for an operation was an empty sella syndrome and in 3 cases the pathological diagnosis was an amorphous masses.
  • In all cases of adenomas the total removal of the tumour was obtained in 71.4 %.
  • [MeSH-major] Endoscopy / methods. Nasal Cavity / surgery. Optic Nerve Glioma / surgery. Pituitary Diseases / surgery. Skull Base Neoplasms / surgery. Sphenoid Sinus / surgery

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  • (PMID = 15906205.001).
  • [ISSN] 0946-7211
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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5. Kobayashi T: Treatment strategy and pathological background of radiosurgery for craniopharyngiomas. Prog Neurol Surg; 2007;20:180-91
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  • [Title] Treatment strategy and pathological background of radiosurgery for craniopharyngiomas.
  • In this paper, pathological aspects of diagnosis, classification, treatment strategy and interstitial radiotherapy for craniopharyngiomas have been discussed and reviewed.
  • Two pathological patterns, adamantinomatous and squamous cell types, are well correlated to the age of the patient, nature and response of tumor to radiation therapy.
  • The originating portion of tumor (so called 'R site') at the retrochiasmal and anterior part of the stalk showed close contact of tumor with hypothalamic neurons without arachnoid membrane or glial cleavage.
  • This means that the total removal of the tumor is difficult without damage to the stalk and optic pathway.
  • A new concept of strategy can be proposed that a small tumor at this portion is intentionally left behind and is treated by gamma radiosurgery.
  • The treatment strategy for large cystic tumor has been important and two methods can be recommended.
  • [MeSH-major] Craniopharyngioma / pathology. Craniopharyngioma / surgery. Pituitary Neoplasms / pathology. Pituitary Neoplasms / surgery. Radiosurgery / methods

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  • (PMID = 17317986.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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6. Dallago CM, Oliveira MC, Barbosa-Coutinho LM, Ferreira NP: Angiogenesis in craniopharyngiomas: Microvascular density and tissue expression of the vascular endothelial growth factor (VEGF) and endostatin. Endocr Pathol; 2005;16(4):355-62
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  • [Title] Angiogenesis in craniopharyngiomas: Microvascular density and tissue expression of the vascular endothelial growth factor (VEGF) and endostatin.
  • Craniopharyngiomas are benign tumors of the sellar region generally associated with endocrine abnormality and often locally aggressive.
  • The microvascular density (MVD) of craniopharyngiomas was determined in tumor tissue samples from a reference neurosurgery center located in southern Brazil using immunohistochemical methods for two endothelial markers, CD34 and CD105 (endoglin).
  • There was no association between the two endothelial markers and tumor extension.
  • We were not able to establish a relationship between angiogenesis in craniopharyngiomas and tumor extension with the endothelial markers used in this study.
  • We believe that CD105 antigen can be a more specific endothelial marker for tumor angiogenesis than CD34 antigen.
  • [MeSH-major] Craniopharyngioma / blood supply. Endostatins / metabolism. Neovascularization, Pathologic / pathology. Pituitary Neoplasms / blood supply. Vascular Endothelial Growth Factor A / metabolism

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  • (PMID = 16627922.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34; 0 / ENG protein, human; 0 / Endoglin; 0 / Endostatins; 0 / Receptors, Cell Surface; 0 / Vascular Endothelial Growth Factor A
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7. Yonekawa Y: [Operative neurosurgery: personal view and historical backgrounds (7) reappraisal of approaches]. No Shinkei Geka; 2010 Nov;38(11):1031-45
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  • Selective extradural anterior clinoidectomy SEAC was once more discussed: 1. the origin of en bloc removal has originated, 2. meaning of an en bloc replacement, if any, and 3. further development of this procedure for low lying upper basilar aneurysms.
  • 2. Trans-sulcus circularis insulae approach TSCIA, which is a part of the selective amygdalohippocampectomy approach SAHEA was applied for removal of a ganglioglioma originating from the head of the hippocampus (cause of intractable temporal lobe epilepsy) of the dominant hemisphere without performing SAHE due to a positive selective Wada test and the full SAHEA for P2 or P2-3 junction aneurysms (Fig. 1, 2, 3).
  • 3. Trans-rostrum corporis callosi-lamina terminalis approach TRCLA revealed to be less invasive and helpful for removal of a small recurrent craniopharyngioma located between the chiasma opticum and the AcomA complex with the use of a small craniotomy, avoiding previous craniotomy routes, both pterional and subfrontal, for fear of structural adhesion (Fig. 4, 5, 6).
  • 4. Within the scope of the trans-lobulus quadrangularis approach TLQA, the paramedian supracerebellar transtentorial approach SCTTA revealed to be useful for removal of a cavernous angioma located at the parahippocampal gyrus corresponding to the head of the hippocampus of the dominant hemisphere, so that the possible impairment of cognitive function could be avoided, because the incision to the temporal stem and to the hippocampus involved in the above mentioned SAHEA could be avoided.
  • [MeSH-minor] Brain Neoplasms / surgery. Humans. Intracranial Aneurysm / surgery

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  • (PMID = 21081816.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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8. Mehrazin M, Rahmat H, Yavari P: Epidemiology of primary intracranial tumors in Iran, 1978-2003. Asian Pac J Cancer Prev; 2006 Apr-Jun;7(2):283-8
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  • [Title] Epidemiology of primary intracranial tumors in Iran, 1978-2003.
  • The pattern of primary brain tumors have not been reported in Iran and the etiology remains largely unknown.
  • The purpose of this study was to review cases of brain tumors treated in Shariatti hospital, a neurosurgical center, over the twenty five years from 1978 to 2003.
  • A descriptive, retrospective study was made of 3,437 cases who were hospitalized with brain tumors.
  • Data abstracted from the patients' clinical records included age at the time of admission , sex, histological diagnosis and tumor location.
  • The frequency distribution of brain tumors by age and sex, and histology was calculated for comparison with the literature.
  • The average age of the patients at the diagnosis was 33.9 years (SD = 18.1) with a median of 34 years and a ranged from 1 to 95 years.
  • Of recorded series cases, 20.1% brain tumors occurred in children 15 years and younger, with a mean + sd of 8.7 + 3.9 years, and 79.9 % of cases in adults with the mean + sd of 40.2 + 14.4.
  • The five most common histological types in both sexes were meningioma in 892 cases (26%) followed by astrocytoma in 805 cases (23.4%), pituitary adenoma in 488 cases (14.2%), glioblasomaoma in 278 cases (5.1%) and ependymoma in 166 cases (4.8%).
  • These accounted for 84 % of all brain tumors.
  • The 10 most frequent brain tumors were ranked separately by sex and age groups.
  • Male predominance was observed for the astrocytoma group, craniopharyngiomas, ependymomas, glioblastomas, medulloblastomas, and pituitary adenomas.
  • Meningiomas were the only tumors with a significant excess in females (p<0.05)-- some 28% of cases occurred in patients younger than 20 years of age; 45% cases 21- 45 years of age; 25% cases 46-65 years of age, and 2% cases in patients older than 65 years of age.
  • In conclusion, the results present an important epidemiological basis for understanding of the brain tumor burden in Iran.
  • Wider epidemiological studies of a prospective nature are now required .
  • [MeSH-major] Brain Neoplasms / epidemiology. Brain Neoplasms / pathology

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  • (PMID = 16839224.001).
  • [ISSN] 1513-7368
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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9. Hargrave DR: Does chemotherapy have a role in the management of craniopharyngioma? J Pediatr Endocrinol Metab; 2006 Apr;19 Suppl 1:407-12
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  • [Title] Does chemotherapy have a role in the management of craniopharyngioma?
  • Craniopharyngiomas are classified as histologically benign tumours that are usually treated by surgery alone or in combination with radiotherapy.
  • However, the difficulty in managing recurrent tumours and the desire to try to avoid treatment-related morbidity from both surgery and irradiation has led to exploration of the role of chemotherapy in this tumour.
  • In the majority of cases this has involved the application of intratumoral bleomycin in cystic craniopharyngiomas.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Craniopharyngioma / drug therapy. Pituitary Neoplasms / drug therapy

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  • (PMID = 16700318.001).
  • [ISSN] 0334-018X
  • [Journal-full-title] Journal of pediatric endocrinology & metabolism : JPEM
  • [ISO-abbreviation] J. Pediatr. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents; 11056-06-7 / Bleomycin
  • [Number-of-references] 29
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10. Kawamata T, Harashima S, Kubo O, Hori T: Intrasellar remote metastasis from adenoid cystic carcinoma of parotid gland: case report. Endocr J; 2006 Oct;53(5):659-63
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  • Adenoid cystic carcinoma is a tumor of exocrine glands originating primarily from the minor and major salivary glands, lacrimal gland, bronchus, breast, and intestinal and genital tracts.
  • Intracranial remote metastasis from adenoid cystic carcinoma in salivary gland is quite rare.
  • Histopathological examination of the tumor specimens revealed adenoid cystic carcinoma, which had identical histological findings as those of the painful superficial cervical lymph nodes resected in the same operation.
  • Tumors such as the present case are easily confused with pituitary adenoma or craniopharyngioma.
  • Although rare, metastasis from tumors including those of salivary gland origin should be considered in the differential diagnosis of unusual pituitary tumors.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Parotid Neoplasms / pathology. Pituitary Neoplasms / secondary. Sella Turcica

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  • (PMID = 16902261.001).
  • [ISSN] 0918-8959
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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11. Olowoyeye OA, Bankole OB: Craniopharyngioma causing visual loss in an adult. Nig Q J Hosp Med; 2008 Jan-Mar;18(1):30-1
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  • [Title] Craniopharyngioma causing visual loss in an adult.
  • Craniopharyngiomas are usually benign tumours, commonly seen in children.
  • This is a case of craniopharyngioma resulting in visual loss in an adult.
  • [MeSH-major] Blindness / etiology. Craniopharyngioma / complications. Pituitary Neoplasms / complications

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  • (PMID = 19062468.001).
  • [ISSN] 0189-2657
  • [Journal-full-title] Nigerian quarterly journal of hospital medicine
  • [ISO-abbreviation] Nig Q J Hosp Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nigeria
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12. Taguchi T, Takao T, Iwasaki Y, Pooh K, Okazaki M, Hashimoto K, Terada Y: Rapid recurrence of craniopharyngioma following recombinant human growth hormone replacement. J Neurooncol; 2010 Nov;100(2):321-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rapid recurrence of craniopharyngioma following recombinant human growth hormone replacement.
  • [MeSH-major] Craniopharyngioma / pathology. Human Growth Hormone / adverse effects. Neoplasm Recurrence, Local / chemically induced. Pituitary Neoplasms / pathology

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  • (PMID = 20349266.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Recombinant Proteins; 12629-01-5 / Human Growth Hormone
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13. Chaney M, Vajtai I: Late development of third ventricular subependymoma following surgery for craniopharyngioma. Clin Neuropathol; 2007 Jan-Feb;26(1):37-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Late development of third ventricular subependymoma following surgery for craniopharyngioma.
  • [MeSH-major] Brain Neoplasms / pathology. Craniopharyngioma / surgery. Glioma, Subependymal / pathology. Pituitary Neoplasms / surgery. Postoperative Complications. Third Ventricle


14. Polezhaev AV, Cherebillo VIu, Savello AV, Svistov DV: [Therapeutic management for iatrogenic injury of great arteries during transnasal surgery of tumors of the hypophysis]. Vestn Khir Im I I Grek; 2008;167(6):71-6
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  • [Title] [Therapeutic management for iatrogenic injury of great arteries during transnasal surgery of tumors of the hypophysis].
  • Results of clinical examination and surgical treatment of 1022 patients with tumors of the hypophysis were analyzed.
  • Most serious of them were: intraoperative mechanical injury of the right internal carotid artery and contact rupture of a large aneurysm of the internal carotid artery falsely diagnosed as craniopharyngioma.
  • [MeSH-major] Carotid Artery Injuries / therapy. Carotid Artery, Internal. Cerebral Arteries / injuries. Embolization, Therapeutic / methods. Endoscopy / adverse effects. Neurosurgical Procedures / adverse effects. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Follow-Up Studies. Humans. Iatrogenic Disease. Magnetic Resonance Imaging. Nose. Tomography, Spiral Computed

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  • (PMID = 19241822.001).
  • [ISSN] 0042-4625
  • [Journal-full-title] Vestnik khirurgii imeni I. I. Grekova
  • [ISO-abbreviation] Vestn. Khir. Im. I. I. Grek.
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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15. Bauchet L, Rigau V, Mathieu-Daudé H, Fabbro-Peray P, Palenzuela G, Figarella-Branger D, Moritz J, Puget S, Bauchet F, Pallusseau L, Duffau H, Coubes P, Trétarre B, Labrousse F, Dhellemmes P, Société Française de Neurochirurgie Pédiatrique, Société Française de Neurochirurgie, Société Française de Neuropathologie, Association des Neuro-Oncologues d'Expression Française: Clinical epidemiology for childhood primary central nervous system tumors. J Neurooncol; 2009 Mar;92(1):87-98
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical epidemiology for childhood primary central nervous system tumors.
  • This work was conducted by the French Brain Tumor Data Bank (FBTDB) and aims to prospectively record all primary central nervous system tumors (PCNST), in France, for which histological diagnosis is available.
  • The Tumor Registry from Herault was authorized to compile the data files with personal identifiers.
  • About 1,017 cases (533 boys and 484 girls) of newly diagnosed childhood PCNST have been recorded (gliomas: 52%, all other neuroepithelial tumors: 31%, craniopharyngioma: 5%, germ cell tumors, meningioma and neurinoma: approximately 3% each, all histological subtypes have been detailed).
  • Tumor resections were performed in 83.3%, and biopsies in 16.7%.
  • The distributions by histology, cryopreservation of the samples, age, sex, tumor site and surgery have been detailed.

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  • (PMID = 19020806.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Investigator] Aghakhani N; Ali Benali M; Alliez B; Amat D; Amlashi A; Arbez-Gindre F; Arbion F; Assaker R; Aubriot Lorton MH; Auque J; Autricque A; Auvigne I; Averous G; Baldet P; Bataille B; Bazin A; Beaurain J; Benezech J; Bergemer Fouquet A; Besson G; Beuvon F; Billotet C; Blond S; Boetto S; Boissonnet H; Bonyhay G; Bouillot P; Bourgeois P; Bouvier C; Brassier G; Broche C; Brunon J; Cabal P; Cahn V; Caire F; Calvet P; Cazals-Hatem D; Chapon F; Chazal J; Civit T; Colnat S; Colombat M; Comoy J; Couvelard A; Czorny A; Dam Hieu P; Daumas-Duport C; Dautheribes M; David P; Debono B; Delage Corre M; Delhaye M; Delisle MB; Delsol G; Derlon JM; Desenclos C; Desplat A; Devaux B; Di Rocco F; Diaz A; Diebold MD; Dorfmuller G; Dran G; Dufour T; Dumas B; Dumollard JM; Durand L; Duthel R; Eimer S; El Fertit H; Emery E; Espagno C; Esposito P; Etchandy MP; Eyremandi RP; Faillot T; Felix S; Fernandez C; Fesselet J; Fontaine D; Fournier D; François P; Froelich S; Fuentes JM; Fuentes S; Gadan R; Gaspard C; Gay G; Gigaud M; Gil Robles S; Godard J; Gontier MF; Goujon JM; Gray F; Grignon Y; Grisoli F; Guarnieri J; Guyotat J; Hallacq P; Hamlat A; Hayek G; Heitzmann A; Hennequin V; Huot JC; Irthum B; Jacquet G; Jan M; Jaubert F; Jouanneau E; Jouvet A; Justrabo E; Kalamarides M; Kehrli P; Kemeny JL; Keravel Y; Kerdraon R; Khalil T; Khouri K; Khouri S; Klein O; Kujas M; Lacroix C; Lagarrigue J; Langlois O; Lapierre F; Laquerriere A; Laurent MC; Le Gall F; Le Guerinel C; Le Houcq M; Lechapt E; Legars D; Lemaire JJ; Lena G; Lepeintre JF; Leriche B; Lescure JP; Levillain P; Liguoro D; Lioret E; Listrat A; Loiseau H; Lonjon M; Lopes M; Lot G; Louis E; Maheut-Lourmière J; Maillard A; Maitre F; Maitrot D; Majek-Zakine E; Mandonnet E; Manzo N; Marchal JC; Marie B; Maurage CA; Menei P; Mercier P; Mergey E; Metellus P; Michalak S; Michiels JF; Milinkevitch S; Mineo JF; Miquel C; Mireau E; Mohr M; Mokhtari K; Morandi X; Morar S; Moreau JJ; Moreno S; Mourier KL; Mottolese C; Nataf F; Neuville A; Nogues L; Noudel R; Nuti C; Page P; Paquis P; Parent M; Parker F; Pasqualini F; Patey M; Pelissou-Guyotat I; Peoc'h M; Peragut JC; Peruzzi P; Pierre-Kahn A; Pinelli C; Polivka M; Pommepuy I; Ponnelle T; Porhiel V; Proust F; Quintin-Roue I; Ragragui O; Rasendrarijao D; Raynaud P; Redondo A; Renjard L; Reyns N; Richard S; Richaud J; Riem T; Riffaud L; Ringenbach F; Robert G; Roche PH; Rodriguez MA; Roujeau T; Rousseaux P; Rousselet MC; Roux FE; Roux FX; Ruchoux MM; Sabatier J; Sabatier P; Saïkali S; Saint Andre JP; Saint Pierre G; Saint-Rose C; San Galli F; Sautreaux JL; Sawan B; Scavarda D; Segnarbieux F; Seigneuret E; Sindou M; Sorbara R; Sorin A; Stilhart B; Straub P; Taha S; Ternier JP; Tortel MC; Toussaint P; Touzet G; Tremoulet M; Trouillas J; Tubiana A; Uro-Coste E; Vandenbos F; Varlet P; Velut S; Vidal J; Viennet G; Vignaud JM; Vignes JR; Vinchon M; Vital A; Wager M; Weinbreck N; Zerah M
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16. Bellil S, Limaiem F, Mahfoudhi H, Bellil K, Chelly I, Mekni A, Jemel H, Khaldi M, Haouet S, Zitouna M, Kchir N: Descriptive epidemiology of childhood central nervous system tumours in Tunisia. experience of a single institution over a 15-year period (1990-2004). Pediatr Neurosurg; 2008;44(5):382-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Descriptive epidemiology of childhood central nervous system tumours in Tunisia. experience of a single institution over a 15-year period (1990-2004).
  • INTRODUCTION: Central nervous system tumours represent 20% of all childhood cancers, and are the second most common group of neoplasms after leukaemias.
  • OBJECTIVE: To describe epidemiological characteristics of central nervous system tumours in a paediatric Tunisian population.
  • PATIENTS AND METHODS: A retrospective study of 492 childhood central nervous system tumours operated between 1990 and 2004 was undertaken.
  • We investigated the age-related location, gender distribution and the histology of all tumours, and adopted the latest WHO classification (2007) in grouping all the tumours.
  • RESULTS: There were 488 primary and 4 secondary tumours; 426 (86.6%) were intracranial and 66 (13.4%) were intraspinal.
  • Of the 426 intracranial tumours, 214 (50.24%) were supratentorial and 212 (49.76%) were infratentorial.
  • The median age at diagnosis was 8 years, with a male:female ratio of 1.14:1.
  • Low-grade tumours (WHO I/II) constituted 67.3% of all lesions and the rest (32.7%) were high-grade tumours (WHO III/IV).
  • The most common tumour found in our series was astrocytoma (38%), followed by medulloblastoma (16.2%), then ependymoma (6.9%), cystic tumours (6.3%) and craniopharyngioma (5.3%).
  • CONCLUSION: In our patient population, the incidence and distribution of central nervous system tumours were similar to those reported in literature.
  • Overall survival rates varied according to tumour location and histopathology.

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  • [Copyright] (c) 2008 S. Karger AG, Basel.
  • (PMID = 18703884.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Switzerland
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17. Binder G, Weber S, Ehrismann M, Zaiser N, Meisner C, Ranke MB, Maier L, Wudy SA, Hartmann MF, Heinrich U, Bettendorf M, Doerr HG, Pfaeffle RW, Keller E, South German Working Group for Pediatric Endocrinology: Effects of dehydroepiandrosterone therapy on pubic hair growth and psychological well-being in adolescent girls and young women with central adrenal insufficiency: a double-blind, randomized, placebo-controlled phase III trial. J Clin Endocrinol Metab; 2009 Apr;94(4):1182-90
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  • Inclusion criteria were ACTH deficiency plus two or more additional pituitary deficiencies, serum DHEA less than 400 ng/ml, and pubertal stage more than B2.
  • Exclusion criteria were cerebral radiation with more than 30 Gy, tumor remission less than 1 yr, amaurosis, hypothalamic obesity, psychiatric disorders, and unstable hormone medication.
  • INTERVENTION: Patients were randomized to placebo (n = 12) or 25 mg HPLC-purified DHEA/d (n = 11) orally for 12 months after stratification into a nontumor (n = 7) and a tumor group (n = 16).
  • RESULTS: In the placebo group, four patients dropped out because of recurrence of craniopharyngioma, manifestation of type 1 diabetes, and change of residence (n = 2); in the DHEA group, one patient dropped out because of recurrent anxiety attacks.
  • [MeSH-minor] Adolescent. Adult. Blood Pressure / drug effects. Blood Pressure / physiology. Brain Neoplasms / epidemiology. Double-Blind Method. Female. Humans. Hydrocortisone / therapeutic use. Obesity / epidemiology. Young Adult

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  • (PMID = 19126625.001).
  • [ISSN] 1945-7197
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 459AG36T1B / Dehydroepiandrosterone; 9002-60-2 / Adrenocorticotropic Hormone; WI4X0X7BPJ / Hydrocortisone
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18. Kendall-Taylor P, Jönsson PJ, Abs R, Erfurth EM, Koltowska-Häggström M, Price DA, Verhelst J: The clinical, metabolic and endocrine features and the quality of life in adults with childhood-onset craniopharyngioma compared with adult-onset craniopharyngioma. Eur J Endocrinol; 2005 Apr;152(4):557-67
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The clinical, metabolic and endocrine features and the quality of life in adults with childhood-onset craniopharyngioma compared with adult-onset craniopharyngioma.
  • BACKGROUND: Craniopharyngioma is a parasellar tumour that, although benign, tends to behave aggressively.
  • OBJECTIVES: To investigate the frequency and severity of problems associated with craniopharyngioma, using the large international database (KIMS) for adult patients with GH deficiency (GHD), and to assess the differences between the adult onset (AO, aged 18 or above) disease and adults with childhood onset (CO) craniopharyngioma.
  • DESIGN: Inclusion criteria were: an established diagnosis of craniopharyngioma, severe GHD and no recent GH treatment.
  • These criteria were fulfilled by 393 (184 female, 209 male) patients; 241 had AO (mean age 28.7 +/- 8.7 years) and 152 had CO disease (age 42.0 +/- 12.3 years).
  • Disease history, clinical features and anthropometric data were recorded at the time of enrolment in the database, and body composition, serum IGF-I, serum lipids and quality of life (QoL) were assessed.
  • RESULTS: Peak age at onset of craniopharyngioma was 15-20 years.
  • Quality of life, assessed by Quality of Life-Assessment of Growth Hormone Deficiency in Adults (QoL-AGHDA) and the Nottingham Health Profile, was markedly reduced in all groups with no significant differences between them; the QoL-AGHDA score correlated with age at onset of both craniopharyngioma and GHD, and also with BMI in AO patients.
  • CONCLUSIONS: These data emphasise the generally poor state of health of patients treated for craniopharyngioma, with respect to endocrine and metabolic function, and also the markedly reduced quality of life.
  • Adults with CO craniopharyngioma were shorter, had lower IGF-I, lower BMI, less obesity and slightly lower blood lipid levels than patients with AO craniopharyngioma.

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  • (PMID = 15817911.001).
  • [ISSN] 0804-4643
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Lipids; 12629-01-5 / Human Growth Hormone; 67763-96-6 / Insulin-Like Growth Factor I
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19. Rudnick EF, DiNardo LJ: Image-guided endoscopic endonasal resection of a recurrent craniopharyngioma. Am J Otolaryngol; 2006 Jul-Aug;27(4):266-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Image-guided endoscopic endonasal resection of a recurrent craniopharyngioma.
  • [MeSH-major] Craniopharyngioma / surgery. Endoscopy. Neoplasm Recurrence, Local / surgery. Otorhinolaryngologic Surgical Procedures. Pituitary Neoplasms / surgery. Surgery, Computer-Assisted

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  • (PMID = 16798405.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Joseph V, Chacko AG: Suprabrow minicraniotomy for suprasellar tumours. Br J Neurosurg; 2005 Feb;19(1):33-7
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  • [Title] Suprabrow minicraniotomy for suprasellar tumours.
  • We present our experience with suprabow minicraniotomy in the excision of 18 suprasellar tumours between May 2001 and September 2003.
  • The tumours included one epidermoid cyst, 10 meningiomas, five craniopharyngiomas and two optico-chiasmatico-hypothalamic (OCHG) gliomas.
  • Both OCHGs were biopsied; one craniopharyngioma was totally excised, the remaining craniopharyngiomas and epidermoid cyst were subtotally excised.
  • The patient with a craniopharyngioma that had a radical excision died of hypothalamic dysfunction.
  • This basal approach through a small craniotomy provided good surgical access to suprasellar tumours with minimal brain retraction.
  • [MeSH-minor] Adolescent. Adult. Child. Craniopharyngioma / radiography. Craniopharyngioma / surgery. Female. Glioma / radiography. Glioma / surgery. Humans. Male. Meningioma / radiography. Meningioma / surgery. Middle Aged. Minimally Invasive Surgical Procedures / methods. Postoperative Complications. Tomography, X-Ray Computed / methods. Treatment Outcome

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  • (PMID = 16147580.001).
  • [ISSN] 0268-8697
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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21. Gupta DK, Ojha BK, Sarkar C, Mahapatra AK, Mehta VS: Recurrence in craniopharyngiomas: analysis of clinical and histological features. J Clin Neurosci; 2006 May;13(4):438-42
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  • [Title] Recurrence in craniopharyngiomas: analysis of clinical and histological features.
  • The aim of this study was to investigate the recurrence patterns and significance of various clinical and histological features as predictors of recurrence in craniopharyngiomas.
  • A series of 234 craniopharyngiomas (156 males, 78 females; age range 1.6-65 years) was reviewed.
  • Peri-operative mortality was 7.4% and tumor recurrence was observed in 26 patients (20.3%).
  • Of the patients with recurrence, one had total tumor excision (recurrence-free survival (RFS) 14 months), four had near-total excision (mean RFS 18.2 months) and 21 had subtotal tumor excision (RFS for symptomatic recurrence 7.1 months).
  • Brain tissue was included in 67 cases and brain invasion was noted in 44 (all were of adamantinous histology).
  • No correlation was noted between histopathological subtyping or brain invasion and recurrence.
  • The significant clinical factors predictive of recurrence included the extent of resection, tumor size greater than 4 cm and cystic tumors.
  • [MeSH-major] Brain Neoplasms / pathology. Craniopharyngioma / pathology. Neoplasm Recurrence, Local / pathology

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  • (PMID = 16678722.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Scotland
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22. Wisoff JH, Jane JA Jr, Selman W, Fahlbusch R: Introduction: Craniopharyngioma. Neurosurg Focus; 2010 Apr;28(4):1 p preceding E1
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  • [Title] Introduction: Craniopharyngioma.
  • [MeSH-major] Craniopharyngioma / therapy. Pituitary Neoplasms / therapy
  • [MeSH-minor] Adult. Child. Humans. Neurosurgical Procedures / methods. Pituitary Irradiation / methods. Risk Assessment

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  • (PMID = 20369435.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Introductory Journal Article
  • [Publication-country] United States
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23. Roth CL, Enriori PJ, Gebhardt U, Hinney A, Müller HL, Hebebrand J, Reinehr T, Cowley MA: Changes of peripheral alpha-melanocyte-stimulating hormone in childhood obesity. Metabolism; 2010 Feb;59(2):186-94
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  • We examined serum alpha-MSH in 52 otherwise healthy children with childhood obesity (Ob; mean age, 11 years; 32 girls/20 boys), 27 normal-weight children of same age, 7 additional obese patients with reduced melanocortin-4 receptor function (MC4Rmut), and 22 patients with craniopharyngioma (CP).
  • Persistently low alpha-MSH levels in CP patients are suspected to be due to pituitary or hypothalamic damage.
  • [MeSH-minor] Adolescent. Body Mass Index. Body Weight. Child. Craniopharyngioma / blood. Female. Genotype. Humans. Hydrocortisone / blood. Insulin / blood. Insulin Resistance. Leptin / blood. Male. Mutation. Pituitary Neoplasms / blood. Receptor, Melanocortin, Type 4 / genetics

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19766264.001).
  • [ISSN] 1532-8600
  • [Journal-full-title] Metabolism: clinical and experimental
  • [ISO-abbreviation] Metab. Clin. Exp.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00258453/ NCT00435734
  • [Grant] United States / NIDDK NIH HHS / DK / DK 62202; United States / NCRR NIH HHS / RR / RR 0163
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Insulin; 0 / Leptin; 0 / Receptor, Melanocortin, Type 4; 581-05-5 / alpha-MSH; WI4X0X7BPJ / Hydrocortisone
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24. Cavallo LM, Messina A, Esposito F, de Divitiis O, Dal Fabbro M, de Divitiis E, Cappabianca P: Skull base reconstruction in the extended endoscopic transsphenoidal approach for suprasellar lesions. J Neurosurg; 2007 Oct;107(4):713-20
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  • OBJECT: The extended transsphenoidal approach to the suprasellar region has the advantages of minimal invasiveness and brain manipulation in the surgical treatment of small to medium lesions.
  • CONCLUSIONS: The rate of postoperative CSF leakage after an extended approach to the suprasellar area is higher compared with that following standard pituitary surgery.
  • Reconstruction after craniopharyngioma surgery exposes patients to an increased risk of postoperative CSF leaks.
  • [MeSH-major] Craniopharyngioma / surgery. Endoscopy / methods. Pituitary Neoplasms / surgery. Reconstructive Surgical Procedures / methods. Skull Base / surgery

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  • (PMID = 17937213.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Bone Substitutes; 0 / Polymers; 0 / polylactic acid-polyglycolic acid copolymer; 26009-03-0 / Polyglycolic Acid; 33X04XA5AT / Lactic Acid
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25. Kamal K, Ozgönenel B, Rabah R, Bhambhani K, Savaşan S: Uncommon presentation of craniopharyngioma with anemia in an adolescent. Pediatr Blood Cancer; 2006 Jan;46(1):117-8
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  • [Title] Uncommon presentation of craniopharyngioma with anemia in an adolescent.
  • [MeSH-major] Anemia / etiology. Craniopharyngioma / diagnosis. Hypopituitarism / etiology. Pituitary Neoplasms / diagnosis


26. Srimanee D, Bhidayasiri R, Phanthumchinda K: Extrapontine myelinolysis in preoperative sellar region tumor: report of two cases. J Med Assoc Thai; 2009 Nov;92(11):1548-53
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  • [Title] Extrapontine myelinolysis in preoperative sellar region tumor: report of two cases.
  • Osmotic demyelination syndrome (ODS) is a well-known disorder caused by rapid correction of serum sodium.
  • Many conditions including hormonal abnormality are associated with this syndrome.
  • The authors describe two cases of preoperative sellar region tumor associated with hypopituitarism and secondary adrenal insufficiency.
  • The first case was a 35-year-old man with craniopharyngioma who developed generalized dystonia after rapid correction of hyponatremia.
  • The second case was a 24-year-old man with gonadotroph pituitary adenoma who developed generalized dystonia, dysarthria, and dysphagia in the course of hyponatremia.
  • Patients with sellar region tumors are at risk of developing ODS and correction of hyponatremia in these cases should be closely monitored.
  • [MeSH-major] Craniopharyngioma / diagnosis. Myelinolysis, Central Pontine / diagnosis. Pituitary Neoplasms / diagnosis
  • [MeSH-minor] Adrenal Insufficiency / complications. Adult. Diagnosis, Differential. Fatal Outcome. Humans. Hyponatremia / complications. Hypopituitarism / complications. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 19938750.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Thailand
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27. Nakajima K, Hashimoto E, Kaneda H, Tokushige K, Shiratori K, Hizuka N, Takano K: Pediatric nonalcoholic steatohepatitis associated with hypopituitarism. J Gastroenterol; 2005 Mar;40(3):312-5
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  • The first patient was diagnosed with a craniopharyngioma at 5 years of age.
  • The second patient was diagnosed, at 10 years of age, as having pituitary dysfunction due to fetal asphyxia, and he was started on hormone replacement therapy.
  • It is important for both hepatologists and endocrinologists to be aware of the association between pituitary dysfunction and NASH.
  • [MeSH-minor] Adiponectin. Adolescent. Biopsy. Diagnosis, Differential. Disease Progression. Follow-Up Studies. Hormone Replacement Therapy. Humans. Intercellular Signaling Peptides and Proteins / blood. Leptin / blood. Liver / pathology. Liver / radiography. Liver / ultrasonography. Male. Obesity / complications. Pituitary Hormones / blood. Pituitary Hormones / deficiency. Tomography, X-Ray Computed

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  • (PMID = 15830293.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Adiponectin; 0 / Intercellular Signaling Peptides and Proteins; 0 / Leptin; 0 / Pituitary Hormones
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28. Andaluz N, Romano A, Reddy LV, Zuccarello M: Eyelid approach to the anterior cranial base. J Neurosurg; 2008 Aug;109(2):341-6
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  • The eyelid approach has evolved from the orbitopterional osteotomy into a more effective and targeted approach to disease of the anterior cranial fossa.
  • A MacCarty bur hole is drilled, and a frontal osteotomy is fashioned medial to the supraorbital notch and extending through the orbital roof back toward the orbital half of the MacCarty bur hole, exposing the frontobasal brain.
  • A conventional microsurgical technique is used to treat tumors and aneurysms of the anterior cranial fossa under the operative microscope.
  • Three tumors in the anterior fossa (2 suprasellar pituitary adenomas and 1 craniopharyngioma) were also excised using this approach.
  • The eyelid approach may be considered as an effective, cosmetically beneficial, and minimally invasive skull base approach to selected aneurysms and tumors of the anterior circulation.
  • [MeSH-major] Eyelids / surgery. Intracranial Aneurysm / surgery. Minimally Invasive Surgical Procedures. Neurosurgical Procedures. Skull Base / surgery
  • [MeSH-minor] Adenoma / surgery. Craniopharyngioma / surgery. Female. Humans. Male. Middle Aged. Ophthalmic Artery. Orbit / surgery. Pituitary Neoplasms / surgery. Treatment Outcome

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  • (PMID = 18671651.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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29. Makino K, Nakamura H, Yano S, Kuratsu J, Kumamoto Brain Tumor Group: Population-based epidemiological study of primary intracranial tumors in childhood. Childs Nerv Syst; 2010 Aug;26(8):1029-34
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  • [Title] Population-based epidemiological study of primary intracranial tumors in childhood.
  • OBJECT: Brain tumors are the most common solid tumors in children and their prognosis is poor.
  • Epidemiologic data from a population-based cancer registry provide the information necessary to determine the incidence rate of pediatric brain tumors.
  • The aim of this study was to determine the epidemiology of childhood primary intracranial tumors in Kumamoto Prefecture, Japan.
  • METHODS: We surveyed 210 patients younger than 15 years who were diagnosed with primary intracranial tumors between 1989 and 2008; 159 (75.7%) of the tumors were confirmed microscopically.
  • The most common tumor was astrocytoma (35.7%) with an annual incidence rate of 13.2 per million, followed by germ cell tumor (14.3%, 5.0 per million), craniopharyngioma (10.5%, 3.8 per million), medulloblastoma (10.0%, 3.7 per million), and ependymoma (4.8%, 1.5 per million).
  • The distribution of the tumor type varied with the patient age and gender.
  • Although there were no germ cell tumors in 0- to 4-year-old boys, they were the second-most common tumor in 10- to 14-year-old boys.
  • CONCLUSIONS: In this Kumamoto survey, the incidence rate of primary intracranial tumors in children was similar to that in Western countries.
  • However, the incidence and relative frequency of particular histological types of childhood brain tumors such as germ cell tumors and craniopharyngiomas were different between Japan and Western countries.
  • [MeSH-major] Brain Neoplasms / epidemiology. Brain Neoplasms / pathology

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  • (PMID = 20349186.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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30. Zhang YQ, Ma ZY, Wu ZB, Luo SQ, Wang ZC: Radical resection of 202 pediatric craniopharyngiomas with special reference to the surgical approaches and hypothalamic protection. Pediatr Neurosurg; 2008;44(6):435-43
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  • [Title] Radical resection of 202 pediatric craniopharyngiomas with special reference to the surgical approaches and hypothalamic protection.
  • OBJECTIVE: The goal of this study was to disclose the appropriate surgical approaches to radically removing pediatric craniopharyngiomas with optimal hypothalamic protection.
  • METHODS: In 202 patients undergoing primary surgery from April 1997 to December 2002, eight approaches were used to remove craniopharyngiomas in the sellar region and the third ventricle.
  • RESULTS: Of the 202 cases, 184 tumors were totally or nearly totally removed (91.1%); 89 cases were resected with the transcallosal-interseptal-interforniceal approach with a total and subtotal removal rate of 92.1%, and 68 cases were removed with the unilateral transfrontal interhemispheric approach with a total and subtotal removal rate of 95.6%.
  • The major postoperative complications included diabetes insipidus in 81.7% of the cases, permanent diabetes insipidus in 11.4%, electrolyte disorder in 74.8%, and seizures in 9.4%.
  • CONCLUSIONS: Appropriate approaches with direct tumor exposure should be determined in order to remove the craniopharyngioma as much as possible, while at the same time carefully protecting the anteroinferolateral wall of the third ventricle (hypothalamus).
  • Active measurements to manage blood sodium disorder and seizures could help to ensure the safety of the operation.
  • [MeSH-major] Craniopharyngioma / surgery. Hypothalamus / surgery. Neurosurgical Procedures / methods. Pituitary Neoplasms / surgery

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 19018151.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Switzerland
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31. Kim SD, Park JY, Park J, Lee JB, Kim SH, Lim DJ: Radiological findings following postsurgical intratumoral bleomycin injection for cystic craniopharyngioma. Clin Neurol Neurosurg; 2007 Apr;109(3):236-41
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  • [Title] Radiological findings following postsurgical intratumoral bleomycin injection for cystic craniopharyngioma.
  • OBJECTIVES: The purpose of this study was to compare the radiological findings before and after intratumoral bleomycin injection in patients with cystic craniopharyngioma so as to define the role of adjuvant intracavitary bleomycin chemotherapy for cystic craniopharyngiomas.
  • PATIENTS AND METHODS: Eleven patients whose craniopharyngioma was confirmed cytologically and/or histologically were retrospectively reviewed.
  • Only the solid portion of the cystic craniopharyngiomas was excised before repeated injections of bleomycin (15-180 mg in total) into the cystic portion through an Ommaya reservoir were given.
  • RESULTS: After the completion of all treatment cycles, the disappearance or shrinkage of the tumor was initially noted in all cases on follow-up CT and/or MR imaging studies.
  • However, tumor recurrence was seen in four cases with a mixed tumor type.
  • CONCLUSION: Postoperative bleomycin injection in cystic craniopharyngioma does not appear to totally eradicate the tumor and does not stop tumor recurrence unless the cyst is the only portion of the craniopharyngioma that is left.
  • Nevertheless, postoperative bleomycin injection decreases and stabilizes tumor size, and thus may be considered as an option of treatment modalities in patients with predominantly cystic craniopharyngiomas.
  • [MeSH-major] Antibiotics, Antineoplastic / therapeutic use. Bleomycin / therapeutic use. Craniopharyngioma. Cysts. Magnetic Resonance Imaging. Pituitary Neoplasms. Tomography, X-Ray Computed
  • [MeSH-minor] Adolescent. Adult. Aged. Brain / pathology. Brain / radiography. Brain / surgery. Child. Combined Modality Therapy. Female. Humans. Injections. Male. Middle Aged. Neurosurgical Procedures. Postoperative Care

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  • (PMID = 17046151.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 11056-06-7 / Bleomycin
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32. Combs SE, Thilmann C, Huber PE, Hoess A, Debus J, Schulz-Ertner D: Achievement of long-term local control in patients with craniopharyngiomas using high precision stereotactic radiotherapy. Cancer; 2007 Jun 1;109(11):2308-14
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  • [Title] Achievement of long-term local control in patients with craniopharyngiomas using high precision stereotactic radiotherapy.
  • BACKGROUND: The long-term outcome in patients with craniopharyngiomas treated with fractionated stereotactic radiotherapy (FSRT) was evaluated.
  • METHODS: A total of 40 patients with craniopharyngiomas were treated between May 1989 and July 2006 with FSRT.
  • Most patients were treated for tumor progression after surgery.
  • Eleven patients presented with stable disease during follow-up.
  • CONCLUSIONS: The long-term outcome of FSRT for craniopharyngiomas is excellent with regard to local control as well as treatment-related side effects.
  • [MeSH-major] Craniopharyngioma / radiotherapy. Pituitary Neoplasms / radiotherapy. Radiotherapy / methods. Stereotaxic Techniques

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  • [Copyright] (c) 2007 American Cancer Society.
  • (PMID = 17469176.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Müller HL: More or less? Treatment strategies in childhood craniopharyngioma. Childs Nerv Syst; 2006 Feb;22(2):156-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] More or less? Treatment strategies in childhood craniopharyngioma.
  • [MeSH-major] Craniopharyngioma / therapy. Pituitary Neoplasms / therapy
  • [MeSH-minor] Child. Disease Management. Humans

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  • [CommentOn] Childs Nerv Syst. 2006 Feb;22(2):151-5; discussion 158-63 [16320025.001]
  • [Cites] Klin Padiatr. 2003 Nov-Dec;215(6):310-4 [14677094.001]
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  • (PMID = 16320024.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Comment; Journal Article
  • [Publication-country] Germany
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34. Frangou EM, Tynan JR, Robinson CA, Ogieglo LM, Vitali AM: Metastatic craniopharyngioma: case report and literature review. Childs Nerv Syst; 2009 Sep;25(9):1143-7
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  • [Title] Metastatic craniopharyngioma: case report and literature review.
  • BACKGROUND: Distant spread of craniopharyngioma is a rare but important complication.
  • We describe a rare case of metastatic leptomeningeal craniopharyngioma as a result of dissemination along CSF pathways in a child.
  • CASE PRESENTATION: A 14-year-old male was diagnosed with metastatic craniopharyngioma on routine follow-up imaging after multiple surgeries and radiation for locally recurrent craniopharyngioma.
  • Histopathology confirmed adamantinomatous craniopharyngioma.
  • DISCUSSION: A review of reported cases suggests that leptomeningeal implantation may be an important step in metastases of craniopharyngioma, although the mechanism is poorly understood.
  • Attention to tumor spillage at the time of surgery may be important in preventing distant recurrences.
  • [MeSH-major] Brain Neoplasms. Craniopharyngioma / secondary. Neoplasm Metastasis
  • [MeSH-minor] Adolescent. Brain / pathology. Brain / surgery. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 19517118.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 39
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35. Kim RJ, Shah R, Tershakovec AM, Zemel BS, Sutton LN, Grimberg A, Moshang T: Energy expenditure in obesity associated with craniopharyngioma. Childs Nerv Syst; 2010 Jul;26(7):913-7
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  • [Title] Energy expenditure in obesity associated with craniopharyngioma.
  • BACKGROUND AND PURPOSE: Obesity is a common yet incompletely understood complication of childhood craniopharyngioma.
  • We hypothesized that craniopharyngioma is associated with specific defects in energy balance compared to obese control children.
  • METHODS: Eleven craniopharyngioma patients were recruited for a study on body composition and energy balance.
  • The obese craniopharyngioma patients had a mean age (+/-SD) of 11.2 +/- 1.7 years.
  • RESULTS: Obese craniopharyngioma patient subjects had increased mean (+/-standard error) fat-free mass compared to obese controls (57% +/- 0.88 % vs 50.0% +/- 0.87%, p = 0.02).
  • The obese craniopharyngioma patients had a 17% lower REE compared to values expected from the World Health Organization equation (1,541 +/- 112.6 vs 1,809 +/- 151.8 kcal; p = 0.01).
  • CONCLUSIONS: Lower REE may be a factor contributing to obesity in children with craniopharyngioma.
  • Further study is needed into the mechanisms for reduced energy expenditure in patients with craniopharyngioma.

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  • (PMID = 20107994.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / DK080644-01A1; United States / NIDDK NIH HHS / DK / K12 DK063682; United States / NCRR NIH HHS / RR / UL1RR024134; United States / NIDDK NIH HHS / DK / K23 DK080644-01A1; United States / NCRR NIH HHS / RR / UL1 RR024134
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Other-IDs] NLM/ NIHMS189864; NLM/ PMC2883002
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36. Cama A, Ravegnani M, Piatelli G, Rossi A, Gandolfo C, Garre ML: Conservative surgical approach in treatment strategy of craniopharyngioma: experience at a single institution in Italy. J Pediatr Endocrinol Metab; 2006 Apr;19 Suppl 1:337-40
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  • [Title] Conservative surgical approach in treatment strategy of craniopharyngioma: experience at a single institution in Italy.
  • [MeSH-major] Craniopharyngioma / surgery. Neurosurgical Procedures. Pituitary Neoplasms / surgery
  • [MeSH-minor] Child. Combined Modality Therapy. Female. Humans. Italy. Neoplasm Recurrence, Local. Quality of Life. Survival. Treatment Outcome

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  • (PMID = 16700309.001).
  • [ISSN] 0334-018X
  • [Journal-full-title] Journal of pediatric endocrinology & metabolism : JPEM
  • [ISO-abbreviation] J. Pediatr. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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37. Honegger J, Tatagiba M: Craniopharyngioma surgery. Pituitary; 2008;11(4):361-73
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  • [Title] Craniopharyngioma surgery.
  • Ideal surgical treatment of craniopharyngiomas remains a major challenge for neurosurgeons.
  • Craniopharyngiomas grow in the deep-seated hypothalamic area that is paramount for vegetative, emotional and endocrine function, and for maintaining worthwhile life.
  • The benign histological nature of craniopharyngiomas belies their biological behavior and the propensity to recur is a major threat.
  • Surgical treatment has to weigh the risk of hypothalamic damage against the risk of tumor recurrence or progression.
  • The contemporary neurosurgical strategy of treating craniopharyngiomas with early and late outcome data is presented.
  • [MeSH-major] Craniopharyngioma / surgery. Neurosurgical Procedures. Pituitary Neoplasms / surgery

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  • (PMID = 18636330.001).
  • [ISSN] 1386-341X
  • [Journal-full-title] Pituitary
  • [ISO-abbreviation] Pituitary
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 11056-06-7 / Bleomycin
  • [Number-of-references] 65
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38. Reith W: [Tumors in the region of the sella turcica]. Radiologe; 2009 Jul;49(7):624-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Tumors in the region of the sella turcica].
  • Tumors of the pituitary gland can lead to limitation of hypophysis function (hypophysis insufficiency) or hypersecretion of different hormones (acromegaly, Cushing's syndrome, prolactinoma, TSH-secreting adenoma).
  • The optic chiasma lies in close proximity to the pituitary gland and can be compressed by tumors leading to visual disturbances (bilateral hemianopsia).
  • Tumors can be separated into hormone secreting and hormone inactive tumors, as well as into microadenoma with a diameter <10 mm and macroadenomas >10 mm.
  • A rare group of tumors of the hypophysis region are craniopharyngiomas, meningiomas, germinomas, gliomas, metastases and granulomotous inflammations, such as sarcoidosis and tuberculosis.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Pituitary Neoplasms / diagnosis. Sella Turcica / diagnostic imaging. Sella Turcica / pathology. Skull Neoplasms / diagnosis. Tomography, X-Ray Computed / methods

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  • (PMID = 19568729.001).
  • [ISSN] 1432-2102
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 17
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39. Puget S, Garnett M, Wray A, Grill J, Habrand JL, Bodaert N, Zerah M, Bezerra M, Renier D, Pierre-Kahn A, Sainte-Rose C: Pediatric craniopharyngiomas: classification and treatment according to the degree of hypothalamic involvement. J Neurosurg; 2007 Jan;106(1 Suppl):3-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pediatric craniopharyngiomas: classification and treatment according to the degree of hypothalamic involvement.
  • OBJECT: The current treatment of craniopharyngiomas is evolving into one of a multimodal approach in which the aim is disease control and improved preservation of quality of life (QOL).
  • The objectives of this study were to identify preoperative prognostic factors in patients with craniopharyngiomas and to develop a risk-based treatment algorithm.
  • METHODS: The authors reviewed data obtained in a retrospective cohort of 66 children (mean age 7.4 years, mean follow-up period 7 years) who underwent resection between 1984 and 2001.
  • The preoperative magnetic resonance imaging grade, clinically assessed hypothalamic function, and the sugeon's operative experience (p = 0.007, p = 0.047, p = 0.035, respectively) significantly predicted poor outcome.
  • In cases in which residual disease was present, the patient underwent radiotherapy.
  • CONCLUSIONS: For many children with craniopharyngiomas, the cost of resection is hypothalamic dysfunction and a poor QOL.
  • By using a preoperative classification system to grade hypothalamic involvement and stratify treatment, the authors were able to minimize devastating morbidity.
  • This was achieved by identifying subgroups in which complete resection or STR, performed by an experienced craniopharyngioma surgeon and with postoperative radiotherapy when necessary, yielded better overall results than the traditional GTR.
  • [MeSH-major] Craniopharyngioma / surgery. Hypothalamic Neoplasms / surgery. Postoperative Complications / etiology
  • [MeSH-minor] Adolescent. Algorithms. Child. Child, Preschool. Cohort Studies. Female. Humans. Hypothalamo-Hypophyseal System / pathology. Hypothalamo-Hypophyseal System / surgery. Infant. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / classification. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / surgery. Neurologic Examination. Prognosis. Prospective Studies. Quality of Life. Retrospective Studies. Risk Factors

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  • [CommentIn] J Neurosurg. 2007 Jun;106(6 Suppl):517-9; author reply 519 [17571327.001]
  • [CommentIn] J Neurosurg. 2007 Jan;106(1 Suppl):1-2; discussion 2 [17233304.001]
  • (PMID = 17233305.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 48
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40. Ghirardello S, Garrè ML, Rossi A, Maghnie M: The diagnosis of children with central diabetes insipidus. J Pediatr Endocrinol Metab; 2007 Mar;20(3):359-75
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  • [Title] The diagnosis of children with central diabetes insipidus.
  • Central diabetes insipidus is the end result of a number of different diseases that affect the hypothalamic-neurohypophyseal system.
  • The known causes of these lesions include germinoma or craniopharyngioma; Langerhans cell histiocytosis; local inflammatory, autoimmune or vascular diseases; trauma resulting from surgery or an accident; sarcoidosis; metastases; and midline cerebral and cranial malformations.
  • Accurate diagnostic differentiation is essential for both safe and effective disease management.
  • Proper etiological diagnosis can be achieved via a series of steps that start with clinical observations and then progress, as needed, to more sophisticated methods.
  • Indeed, magnetic resonance imaging (MRI) represents the examination method of choice for evaluating hypothalamic-pituitary-related endocrine diseases due to its ability to provide strongly-contrasted high-resolution multi-planar and spatial images.
  • Specifically, MRI allows a detailed and precise anatomical study of the pituitary gland by differentiating between the anterior and posterior pituitary lobes.
  • MRI identification of pituitary hyperintensity in the posterior part of the sella, now considered to be a clear marker of neurohypophyseal functional integrity, together with careful analysis of pituitary stalk shape and size, have provided the most striking recent findings contributing to the diagnosis and understanding of some forms of 'idiopathic' central diabetes insipidus.
  • [MeSH-major] Brain Neoplasms / pathology. Craniopharyngioma / pathology. Diabetes Insipidus, Neurogenic / pathology. Germinoma / pathology. Magnetic Resonance Imaging


41. Frazier JL, Chaichana K, Jallo GI, Quiñones-Hinojosa A: Combined endoscopic and microscopic management of pediatric pituitary region tumors through one nostril: technical note with case illustrations. Childs Nerv Syst; 2008 Dec;24(12):1469-78
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  • [Title] Combined endoscopic and microscopic management of pediatric pituitary region tumors through one nostril: technical note with case illustrations.
  • MATERIALS AND METHODS: Five craniopharyngiomas, one Rathke's cleft cyst, and two pituitary tumors were treated via endonasal endoscopic-assisted microsurgery.
  • Histopathologic examination revealed lymphocytic hypophysitis in one patient with an enhancing lesion in the pituitary stalk.
  • [MeSH-major] Craniopharyngioma / surgery. Endoscopy / methods. Microsurgery / methods. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Central Nervous System Cysts / diagnosis. Central Nervous System Cysts / surgery. Child. Child, Preschool. Female. Humans. Male. Nasal Cavity. Nasal Septum / surgery. Neurosurgical Procedures / methods. Sella Turcica / surgery. Treatment Outcome. Turbinates / surgery

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  • (PMID = 18769925.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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42. Rossi A, Cama A, Consales A, Gandolfo C, Garrè ML, Milanaccio C, Pavanello M, Piatelli G, Ravegnani M, Tortori-Donati P: Neuroimaging of pediatric craniopharyngiomas: a pictorial essay. J Pediatr Endocrinol Metab; 2006 Apr;19 Suppl 1:299-319
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neuroimaging of pediatric craniopharyngiomas: a pictorial essay.
  • Craniopharyngiomas are benign, partly cystic epithelial tumors that account for 5-13% of all intracranial tumors and 50% of all suprasellar masses in children.
  • This paper aims to focus on the main issues regarding the neuroradiological diagnosis and follow-up after treatment.
  • (iv) the differential diagnosis with other tumoral and non-tumoral entities occurring in the sellar/suprasellar area; and (v) post-treatment imaging issues.
  • [MeSH-major] Craniopharyngioma / pathology. Pituitary Neoplasms / pathology
  • [MeSH-minor] Brain / pathology. Child. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 16700305.001).
  • [ISSN] 0334-018X
  • [Journal-full-title] Journal of pediatric endocrinology & metabolism : JPEM
  • [ISO-abbreviation] J. Pediatr. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 24
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43. Miller ML, Kaufman BA, Lew SM: Modified osteoplastic orbitozygomatic craniotomy in the pediatric population. Childs Nerv Syst; 2008 Jul;24(7):845-50
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  • OBJECT: Anterior and anterolateral skull base approaches offer the advantages of improved visualization and minimal brain retraction for lesions involving the orbital apex, parasellar regions, and anterior and middle fossa floors.
  • Pathology included craniopharyngioma (three), frontal epidural abscess-subdural empyema with intraorbital extension (one), hypothalamic hamartoma (one), and optic pathway glioma (one).
  • (2) superior exposure and therefore less brain retraction;.
  • [MeSH-minor] Adolescent. Brain Diseases / surgery. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Male. Osteogenesis. Treatment Outcome

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  • (PMID = 18236050.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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44. Di Dio G, Zanetta F, Zanetta S, Petri A, Bellone S, Bona G: [Polyuria and polydipsia in a 5 year-old child: diagnostic problems]. Minerva Pediatr; 2007 Dec;59(6):813-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Esordio di poliuria e polidipsia in una bambina di 5 anni: le problematiche della diagnosi differenziale.
  • In particular, CDI can be caused by lesions like germinoma and craniopharyngioma, Langerhans'cell histiocytosis, inflammatory, autoimmune and vascular diseases, trauma resulting from surgery or an accident; and in rare cases, genetic defects in the synthesis of vasopressin that are inherited as autosomal dominant or X-linked recessive traits.
  • Here we present the case of a 5.5 year-old female patient, referred to our Department of Endocrinology Surgery for polyuria and polydipsia.
  • Hormonal tests demonstrated the presence of CDI with normal anterior pituitary function.
  • Magnetic resonance imaging showed the lack of hyperintensity of posterior pituitary.
  • Pituitary stalk was median and of regular volume.
  • Diagnosis of CDI has been confirmed and therapy has been started with desmopressin (Minirin) 0.2 mg/die.
  • Anterior pituitary function was normal and MR remained stable.
  • This case report highlights problems concerning differential diagnosis and the importance of a careful follow-up which must involve the whole family.
  • [MeSH-major] Diabetes Insipidus / diagnosis. Drinking Behavior. Polyuria / diagnosis. Water
  • [MeSH-minor] Child, Preschool. Diagnosis, Differential. Female. Humans

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  • (PMID = 17978791.001).
  • [ISSN] 0026-4946
  • [Journal-full-title] Minerva pediatrica
  • [ISO-abbreviation] Minerva Pediatr.
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 059QF0KO0R / Water
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45. Tanaka Y, Takemae T, Kobayashi S, Sakai K, Miyahara T, Ishizaka S, Kodama K, Kobayashi T, Ichikawa Y, Tsutsumi K, Hongo K: [Clinical analysis of treatment and long-term outcome in 56 craniopharyngiomas]. No Shinkei Geka; 2007 Sep;35(9):887-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical analysis of treatment and long-term outcome in 56 craniopharyngiomas].
  • In order to improve QOL in patients with craniopharyngioma, retrospective analysis was performed to discover factors for influencing functional outcome and the best treatment strategy.
  • Subtotal tumor resection with prophylactic radiation was performed in 8 patients (Group D).
  • Tumor recurrence was noted in 19 patients and stereotactic radiation or 2nd operation was performed in 11 patients (Group B).
  • Factors leading to poor outcome included extrasellar origin, solid tumor, bad score before treatment, 2nd surgery for recurrence.
  • Maximum tumor removal should be attempted with functional preservation.
  • [MeSH-major] Craniopharyngioma / surgery. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Treatment Outcome

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  • (PMID = 17867308.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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46. Fraioli MF, Contratti F, Fraioli C: Craniopharyngioma. J Neurosurg; 2007 Jun;106(6 Suppl):517-9; author reply 519
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Craniopharyngioma.
  • [MeSH-major] Craniopharyngioma / classification. Craniopharyngioma / surgery. Hypothalamus / physiopathology. Neurosurgical Procedures. Pituitary Neoplasms / classification. Pituitary Neoplasms / surgery

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  • [CommentOn] J Neurosurg. 2007 Jan;106(1 Suppl):3-12 [17233305.001]
  • (PMID = 17571327.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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47. Mazumdar A: Imaging of the pituitary and sella turcica. Expert Rev Anticancer Ther; 2006 Sep;6 Suppl 9:S15-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imaging of the pituitary and sella turcica.
  • The pituitary gland is housed in the sella turcica and has vital endocrinologic functions.
  • An understanding of the function, anatomy and embryology of the pituitary gland and its surrounding structures is vital to understanding its normal appearance, as well as in evaluating the broad spectrum of pathology that can involve the pituitary gland.
  • Imaging of pathology in the sellar region, including pituitary adenomas, meningiomas, craniopharyngiomas and aneurysms, plays an important role in guiding treatment decisions.
  • Modern imaging techniques are also important in evaluating the pituitary gland after surgery.
  • [MeSH-major] Pituitary Gland / radiography. Sella Turcica / radiography
  • [MeSH-minor] Animals. Humans. Magnetic Resonance Imaging / methods. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / pathology. Pituitary Neoplasms / radiography. Tomography, X-Ray Computed / methods

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  • (PMID = 17004852.001).
  • [ISSN] 1744-8328
  • [Journal-full-title] Expert review of anticancer therapy
  • [ISO-abbreviation] Expert Rev Anticancer Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 51
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48. Pascual JM, Carrasco R, Prieto R, Gonzalez-Llanos F, Alvarez F, Roda JM: Craniopharyngioma classification. J Neurosurg; 2008 Dec;109(6):1180-2; author reply 1182-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Craniopharyngioma classification.
  • [MeSH-major] Craniopharyngioma / classification. Pituitary Neoplasms / classification
  • [MeSH-minor] Endoscopy / methods. Humans. Neurosurgical Procedures / methods. Pituitary Gland, Posterior / pathology. Pituitary Gland, Posterior / surgery. Treatment Outcome

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  • [CommentOn] J Neurosurg. 2008 Apr;108(4):715-28 [18377251.001]
  • (PMID = 19035739.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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49. Qiu SJ, Guo YL, Zhang XL, Zhang F, Zhang YZ, Wen G, Hu BS: [Imaging findings of craniopharyngioma in relation to its surgical management: a retrospective analysis]. Nan Fang Yi Ke Da Xue Xue Bao; 2007 Jul;27(7):980-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Imaging findings of craniopharyngioma in relation to its surgical management: a retrospective analysis].
  • OBJECTIVE: To analyze the CT and magnetic resonance imaging (MRI) findings of craniopharygioma and explore the correlation between the pathological findings and clinical features of the disease.
  • Of the 123 craniopharyngioma patients, 59 were found to have adamantinous craniopharyngiomas, 41 had papillary squamous craniopharyngiomas, and 23 had mixed tumors.
  • Solid tumor was found in 18 cases, cystic tumor in 38 cases, and calcification in 78 cases; in 23 cases, the posterior of the tumor did not exhibit clear boundary from the wall of the three cerebral ventricles, and in 11 cases CT and MRI displayed hypophysial stalk, which was found intraoperatively in 53 cases.
  • CONCLUSIONS: MRI allows clear vision of the range of craniopharyngioma involvement and the anatomical structures surrounding the tumor.
  • Accurate identification of the site, dimension, calcification patterns and relation between the hypophysial stalk and hypothalamus by the imaging modalities significantly benefits the optimization of the surgical plan for the tumor.
  • [MeSH-major] Craniopharyngioma / diagnosis. Craniopharyngioma / surgery. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 17666331.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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50. Sadeghi M, Moradi S, Shahzadi S, Pourbeigi H: Dosimetry of (32)P radiocolloid for treatment of cystic craniopharyngioma. Appl Radiat Isot; 2007 May;65(5):519-23
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  • [Title] Dosimetry of (32)P radiocolloid for treatment of cystic craniopharyngioma.
  • In Tajrish Shohada Hospital, patients with either cystic craniopharyngiomas or cystic astrocytomas have been treated with (32)P radiocolloid by stereotactic procedure.
  • [MeSH-major] Computer Simulation. Craniopharyngioma / radiotherapy. Cysts / radiotherapy

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  • (PMID = 17350270.001).
  • [ISSN] 0969-8043
  • [Journal-full-title] Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
  • [ISO-abbreviation] Appl Radiat Isot
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Colloids; 0 / Phosphorus Radioisotopes; 0 / Radiopharmaceuticals
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51. Sun HI, Akgun E, Bicer A, Ozkan A, Bozkurt SU, Kurtkaya O, Koc DY, Pamir MN, Kilic T: Expression of angiogenic factors in craniopharyngiomas: implications for tumor recurrence. Neurosurgery; 2010 Apr;66(4):744-50; discussion 750
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of angiogenic factors in craniopharyngiomas: implications for tumor recurrence.
  • BACKGROUND: The primary treatment for craniopharyngiomas is total excision, but recurrence is common.
  • OBJECTIVE: We hypothesized that recurrence is linked to the angiogenesis of the tumor.
  • Recurrent and nonrecurrent tumor samples were compared with regard to expression of angiogenesis-related factors and angiogenic capacity in a corneal angiogenesis model.
  • METHODS: Specimens of 4 recurrent and 6 nonrecurrent tumors were selected from 57 patients with adamantinomatous craniopharyngiomas.
  • RESULTS: Expression of PDGFR-alpha and FGF-2 were significantly higher for recurrent tumors (P = .02 and P = .01).
  • However, recurrent and nonrecurrent tumors did not differ in the expressions of other ligands and receptors (PDGF-A, PDGF-B, and PDGFR-beta).
  • Recurrent tumors displayed a higher angiogenic potential starting from the fifth day of corneal angiogenesis assay.
  • CONCLUSION: These findings suggest a relationship between recurrence of craniopharyngiomas and angiogenesis.
  • New treatment modalities with selective PDGFR-alpha blockers may represent a novel and effective therapeutic option for the treatment of craniopharyngiomas.
  • [MeSH-major] Angiogenesis Inducing Agents / metabolism. Craniopharyngioma / metabolism. Gene Expression Regulation, Neoplastic / physiology. Neoplasm Recurrence, Local / metabolism. Pituitary Neoplasms / metabolism
  • [MeSH-minor] Adult. Animals. Cornea / metabolism. Cornea / pathology. Disease Models, Animal. Female. Fibroblast Growth Factor 2 / metabolism. Fibronectins / metabolism. Humans. Male. Middle Aged. Neoplasm Transplantation. Platelet-Derived Growth Factor / metabolism. Rats. Rats, Sprague-Dawley. Retrospective Studies. Statistics, Nonparametric. Time Factors. Vascular Endothelial Growth Factor A / metabolism. Young Adult

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  • (PMID = 20190664.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inducing Agents; 0 / Fibronectins; 0 / Platelet-Derived Growth Factor; 0 / Vascular Endothelial Growth Factor A; 103107-01-3 / Fibroblast Growth Factor 2
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52. Jagannathan J, Dumont AS, Jane JA Jr, Laws ER Jr: Pediatric sellar tumors: diagnostic procedures and management. Neurosurg Focus; 2005 Jun 15;18(6A):E6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pediatric sellar tumors: diagnostic procedures and management.
  • The diagnosis and management of pediatric sellar lesions is discussed in this paper.
  • Craniopharyngiomas account for the majority of pediatric sellar masses, and pituitary adenomas are extremely uncommon during childhood.
  • The diagnosis of sellar lesions involves a multidisciplinary effort, and detailed endocrinological, ophthalmological, and neurological testing is critical in the evaluation of a new sellar mass.
  • The management of pituitary adenomas varies depending on the entity.
  • For most tumors other than prolactinomas, transsphenoidal resection remains the mainstay of treatment.
  • [MeSH-major] Craniopharyngioma / diagnosis. Craniopharyngioma / therapy. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / therapy. Sella Turcica / pathology

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  • (PMID = 16048292.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 57
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53. Campanini ML, Colli LM, Paixao BM, Cabral TP, Amaral FC, Machado HR, Neder LS, Saggioro F, Moreira AC, Antonini SR, de Castro M: CTNNB1 gene mutations, pituitary transcription factors, and MicroRNA expression involvement in the pathogenesis of adamantinomatous craniopharyngiomas. Horm Cancer; 2010 Aug;1(4):187-96
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  • [Title] CTNNB1 gene mutations, pituitary transcription factors, and MicroRNA expression involvement in the pathogenesis of adamantinomatous craniopharyngiomas.
  • Genes involved in formation/development of the adenohypophysis, CTNNB1 gene, and microRNAs might be implicated in the craniopharyngioma pathogenesis.
  • The objective of this study is to perform the molecular analysis of HESX1, PROP1, POU1F1, and CTNNB1 genes and evaluate a panel of miRNA expression in craniopharyngioma.
  • The study included 16 patients with adamantinomatous craniopharyngioma (nine children and seven adults; eight females and eight males; 6-55 years, median 15.5 years).
  • DNA, RNA, and cDNA were obtained from craniopharyngioma and normal pituitaries.
  • We found no mutations in HESX1, PROP1, and POU1F1 genes and four polymorphisms in PROP1 gene which were in Hardy-Weinberg equilibrium and had similar allelic frequencies in craniopharyngioma and controls.
  • We observed hyperexpression of miR-150 (1.7-fold); no different expression of miR-16-1, miR-21, and miR23a; and an underexpression of miR-141, let-7a, miR-16, miR-449, miR-145, miR-143, miR-23b, miR-15a, and miR-24-2 (ranging from -7.5 to -2.5-fold; p = 0.02) in craniopharyngioma.
  • There was no association between tumor size or the recurrence and the presence of CTNNB1mutations. miR-16 and miR-141 were underexpressed in craniopharyngioma presenting CTNNB1 mutations. miR-23a and miR24-2 were hyperexpressed in patients who underwent only one surgery.
  • Mutations or polymorphisms in pituitary transcription factors are unlikely to contribute to the adamantinomatous craniopharyngioma pathogenesis, differently of CTNNB1 mutations.
  • Our data suggest the potential involvement of the deregulation of miRNA expression in the craniopharyngioma pathogenesis and outcome and also that the miRNA could modulate the Wnt signaling pathway in craniopharyngioma tumorigenesis.
  • [MeSH-major] Craniopharyngioma / genetics. MicroRNAs / genetics. Pituitary Neoplasms / genetics. Transcription Factors / genetics. beta Catenin / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Gene Frequency. Genetic Predisposition to Disease. Genotype. Homeodomain Proteins / genetics. Humans. Male. Middle Aged. Mutation. Pituitary Gland / metabolism. Pituitary Gland / pathology. Polymorphism, Single Nucleotide. Transcription Factor Pit-1 / genetics. Young Adult

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  • (PMID = 21761366.001).
  • [ISSN] 1868-8500
  • [Journal-full-title] Hormones & cancer
  • [ISO-abbreviation] Horm Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / HESX1 protein, human; 0 / Homeodomain Proteins; 0 / MicroRNAs; 0 / POU1F1 protein, human; 0 / Prophet of Pit-1 protein; 0 / Transcription Factor Pit-1; 0 / Transcription Factors; 0 / beta Catenin
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54. Li GM, Sun XJ, Shao P: Postoperative pituitary hormonal disturbances and hormone replacement therapy time and dosage in children with craniopharyngiomas. Chin Med J (Engl); 2008 Oct 20;121(20):2077-82
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  • [Title] Postoperative pituitary hormonal disturbances and hormone replacement therapy time and dosage in children with craniopharyngiomas.
  • BACKGROUND: The proliferative activity and penetration into the hypothalamic structures in children craniopharyngiomas (CP) often make radical resection difficult.
  • Therefore, complete resection of CP often results in permanent multiple pituitary hormone deficiency (MPHD).
  • This study aimed to elucidate the postoperative pituitary hormonal disturbances, and hormone replacement therapy (HRT) time and dosage in children with CP.
  • The serum IGF-1 concentration increased to the normal level after 3 months of rhGH therapy; the serum FSH, LH, and T levels were significantly decreased (P < 0.001); however, E2 and PRL were significantly increased (P < 0.001) in Group B compared with the control Group B; 18 cases were found to have central diabetes insipidus (DI) by water deprivation test and MRI.
  • [MeSH-major] Craniopharyngioma / surgery. Hormone Replacement Therapy. Pituitary Hormones / blood. Pituitary Neoplasms / surgery

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  • (PMID = 19080279.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Pituitary Hormones; 12629-01-5 / Human Growth Hormone; 67763-96-6 / Insulin-Like Growth Factor I; 9002-71-5 / Thyrotropin; Q51BO43MG4 / Thyroxine; WI4X0X7BPJ / Hydrocortisone
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55. Oertel J, Gen M, Krauss JK, Zumkeller M, Gaab MR: The use of waterjet dissection in endoscopic neurosurgery. Technical note. J Neurosurg; 2006 Dec;105(6):928-31
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  • In two patients the hydrocephalus was due to intraventricular hemorrhage, in one a posterior fossa tumor, and in one a cystic craniopharyngioma.
  • Using a pressure setting of 10 bars, the waterjet device successfully perforated the cyst wall of the craniopharyngioma in one patient and the floor of the third ventricle in three patients.
  • [MeSH-major] Brain / surgery. Dissection / instrumentation. Neuroendoscopes
  • [MeSH-minor] Animals. Cerebellar Neoplasms / surgery. Cerebral Hemorrhage / surgery. Craniopharyngioma / surgery. Equipment Design. Hemostasis, Surgical. Humans. Hydrocephalus / surgery. Hydrostatic Pressure. Pituitary Neoplasms / surgery. Swine. Ventriculostomy / instrumentation

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  • (PMID = 17405269.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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56. Guo CJ, Wang YC, Zhou ZH, Zhu JX, Li ZM, Guo CL: [Curative effect of stereotactic 186Re endocavitary irradiation on cystic craniopharyngioma]. Zhonghua Zhong Liu Za Zhi; 2010 Jul;32(7):548-50
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  • [Title] [Curative effect of stereotactic 186Re endocavitary irradiation on cystic craniopharyngioma].
  • OBJECTIVE: To evaluate the treatment results of stereotactic (186)Re intracavitary irradiation in the patients with craniopharyngioma.
  • The mean volume of the cystic portion of the tumor before irradiation was 8390 mm(3).
  • No hypopituitarism occurred in patients with normal pituitary function before treatment.
  • CONCLUSION: Stereotactic (186)Re endocavitary irradiation for the treatment of cystic craniopharyngioma is a safe and effective procedure.
  • [MeSH-major] Brachytherapy / methods. Craniopharyngioma / radiotherapy. Pituitary Neoplasms / radiotherapy. Radioisotopes / therapeutic use. Rhenium / therapeutic use

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  • (PMID = 21029702.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Radioisotopes; 7440-15-5 / Rhenium
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57. Jung TY, Jung S, Moon KS, Kim IY, Kang SS, Kim JH: Endocrinological outcomes of pediatric craniopharyngiomas with anatomical pituitary stalk preservation: preliminary study. Pediatr Neurosurg; 2010;46(3):205-12
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  • [Title] Endocrinological outcomes of pediatric craniopharyngiomas with anatomical pituitary stalk preservation: preliminary study.
  • OBJECTIVE: We reviewed 17 pediatric craniopharyngioma patients, with a special focus on endocrinological outcomes and tumor recurrence with pituitary stalk preservation.
  • The most frequent major presenting symptom was increased intracranial pressure (in 76.5%), followed by visual disturbance (in 23.5%).
  • Tumors were totally removed in 70.6% of patients, subtotally removed in 23.5% and partially removed in 5.9%.
  • The overall tumor recurrence and re-growth rate were 52.9%.
  • In patients who did not receive radiotherapy immediately after their first operation, the recurrence-free survival rate differed between those with pituitary stalk preservation and those with stalk section (p = 0.04).
  • Two patients who had undergone a second operation for recurrences died.
  • CONCLUSIONS: Pediatric craniopharyngiomas had high recurrence rates and low pituitary functional preservation despite anatomical stalk preservation.
  • Therefore, maximal tumor resection might be more important than anatomical stalk preservation in pediatric craniopharyngiomas.
  • [MeSH-major] Craniopharyngioma. Neoplasm Recurrence, Local / epidemiology. Neurosurgical Procedures / methods. Pituitary Gland / physiology. Pituitary Neoplasms
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Disease-Free Survival. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Male. Pilot Projects. Postoperative Complications / epidemiology. Postoperative Complications / physiopathology. Risk Factors. Treatment Outcome. Vision Disorders / epidemiology

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  • [Copyright] Copyright © 2010 S. Karger AG, Basel.
  • (PMID = 20962554.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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58. Cappabianca P, Esposito F, Magro F, Cavallo LM, Solari D, Stella L, de Divitiis O: Natura abhorret a vacuo--use of fibrin glue as a filler and sealant in neurosurgical "dead spaces". Technical note. Acta Neurochir (Wien); 2010 May;152(5):897-904
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  • METHODS: In a 3-year period, 40 subjects underwent endoscopic endonasal approach for different sellar and skull base lesions (three tuberculum sellae meningiomas, six craniopharyngiomas, three Rathke's cleft cysts and 28 pituitary macroadenomas), in which an intraoperative CSF leakage was evident.
  • Furthermore, ten other patients, who had undergone transsphenoidal (four cases), spinal (two cases), posterior fossa (three cases) and transcortical intraventricular tumour removal (one case) neurosurgical procedures and developed CSF leaks or collections, were conservatively treated by single or repeated in situ injections of "modified" fibrin glue under local anaesthesia according to different described techniques.
  • TECHNIQUE: In the cases where the fibrin glue was used during the reconstruction phase of the procedure (40 cases), the glue was injected inside the tumour cavity to fill the dead space left by the removal of the lesion.

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  • (PMID = 20049488.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Fibrin Tissue Adhesive; 0 / Tissue Adhesives
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59. Ohmori K, Collins J, Fukushima T: Craniopharyngiomas in children. Pediatr Neurosurg; 2007;43(4):265-78
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  • [Title] Craniopharyngiomas in children.
  • BACKGROUND: The modern era of pediatric craniopharyngioma treatment includes multiple modalities including microsurgical resection, irradiation, brachytherapy or chemotherapy.
  • The aim of this study was to describe the techniques and strategies for the treatment of pediatric craniopharyngiomas in light of a literature review with particular attention to the incidence of adverse postoperative effects.
  • METHODS: Twenty-seven pediatric patients (median age 9.0 years) who were surgically treated for craniopharyngiomas were evaluated.
  • We reviewed the recent literature for clinical features of craniopharyngiomas in children, including the present cases.
  • CONCLUSIONS: For patients in whom early postoperative MRI reveals complete craniopharyngioma removal, a very low rate of recurrence is anticipated.
  • In the authors' experience, radiographically total excision of even large craniopharyngiomas can be safely achieved by one or a combination of several advanced microsurgical techniques, sometimes by a staged strategy.
  • [MeSH-major] Craniopharyngioma / surgery. Neurosurgical Procedures / methods. Pituitary Neoplasms / surgery

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  • [Copyright] Copyright (c) 2007 S. Karger AG, Basel.
  • (PMID = 17627142.001).
  • [ISSN] 1016-2291
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 61
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60. Zhou L, Li Q, Luo L, Xu J, Zhang Y, Chen T, Wei Y, You C: Radiological features of craniopharyngiomas located in the posterior fossa. J Neurol Sci; 2009 Dec 15;287(1-2):119-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiological features of craniopharyngiomas located in the posterior fossa.
  • BACKGROUND AND PURPOSE: Posterior fossa craniopharyngiomas (PFCP) constitute 1.6-4% of all craniopharyngiomas and have long been neglected.
  • METHODS: CT and/or MR imaging features (with and without contrast enhancement) of 7 patients who underwent craniotomies for histologically proved PFCP were reviewed and analyzed retrospectively.
  • Seven tumors were of retrochiasmatic origin and 5 of 7 were of retrostalk growth pattern with location in the ventral area of brain stem.
  • On CT scans, tumors were isodense in solid component and hypodense in cystic component with (4/7) or without calcification (3 /7) and destruction in sellae turcia (2/7).
  • Tumors demonstrated cyst formation (7/7) with hypointense on T1-weighted imaging and hyperintense on T2-weighted imaging in 5 cases, hyperintense both on T1- and T2-weighted imaging in 2 cases.
  • Total tumor removal was accomplished in 5 cases, subtotal removal and partial removal in 1 case respectively.
  • CONCLUSIONS: PFCPs are well demarcated, contrast-enhanced tumors, typically with cystic parts or purely cyst.
  • Tumor with cystic component arises from sellar region and then extends to posterior fossa, which should be strongly suspected as a PFCP.
  • [MeSH-major] Cranial Fossa, Posterior / pathology. Craniopharyngioma / pathology. Infratentorial Neoplasms / pathology. Pituitary Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Central Nervous System Cysts / etiology. Central Nervous System Cysts / pathology. Central Nervous System Cysts / radiography. Child. Cohort Studies. Craniotomy / methods. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Neurosurgical Procedures. Pituitary Gland / pathology. Pituitary Gland / radiography. Pituitary Gland / surgery. Sella Turcica / pathology. Sella Turcica / radiography. Sella Turcica / surgery. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19758604.001).
  • [ISSN] 1878-5883
  • [Journal-full-title] Journal of the neurological sciences
  • [ISO-abbreviation] J. Neurol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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61. Bawden HN, Salisbury S, Eskes G, Morehouse R: Neuropsychological functioning following craniopharyngioma removal. J Clin Exp Neuropsychol; 2009 Jan;31(1):140-4
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  • [Title] Neuropsychological functioning following craniopharyngioma removal.
  • The neuropsychological functioning of patients who had undergone surgical removal of craniopharyngiomas was compared to that of an endocrine control group composed of patients with nontumor hypopituitarism, an obese control group, and a normal control group.
  • The craniopharyngioma group had lower Performance IQ than did the normal control group, but their Performance IQ was comparable to that of the hypopituitarism and obese control groups.
  • The craniopharyngioma patients did not differ in Verbal or Full Scale IQs from the remaining groups.
  • The group mean scores on the measures of intelligence and neuropsychological abilities for the craniopharyngioma patients were in the low-average to average range.
  • While craniopharyngioma patients can have significant morbidity including endocrine and visual deficits as well as obesity resulting from hyperphagia, neuropsychological deficits are not always present.
  • Their neuropsychological outcome is more benign than some previous studies have suggested.
  • [MeSH-major] Craniopharyngioma / physiopathology. Neuropsychological Tests. Pituitary Neoplasms / physiopathology

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  • (PMID = 18608690.001).
  • [ISSN] 1744-411X
  • [Journal-full-title] Journal of clinical and experimental neuropsychology
  • [ISO-abbreviation] J Clin Exp Neuropsychol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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62. Lehman NL: The ubiquitin proteasome system in neuropathology. Acta Neuropathol; 2009 Sep;118(3):329-47
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  • In neuropathology, alteration of the UPS, or mutations in UPS target proteins may result in signaling abnormalities leading to the initiation or progression of tumors such as astrocytomas, hemangioblastomas, craniopharyngiomas, pituitary adenomas, and medulloblastomas.
  • Dysregulation of the UPS may also contribute to tumor progression by perturbation of DNA replication and mitotic control mechanisms, leading to genomic instability.
  • In neurodegenerative diseases caused by the expression of mutant proteins, the cellular accumulation of these proteins may overload the UPS, indirectly contributing to the disease process, e.g., sporadic Parkinsonism and prion diseases.
  • [MeSH-minor] Brain Diseases / metabolism. Brain Neoplasms / metabolism. Humans. Neurodegenerative Diseases / metabolism. Substrate Specificity

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  • (PMID = 19597829.001).
  • [ISSN] 1432-0533
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / K08 NS045077
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Ubiquitin; EC 3.4.25.1 / Proteasome Endopeptidase Complex
  • [Number-of-references] 149
  • [Other-IDs] NLM/ PMC2716447
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63. Dhellemmes P, Vinchon M: Radical resection for craniopharyngiomas in children: surgical technique and clinical results. J Pediatr Endocrinol Metab; 2006 Apr;19 Suppl 1:329-35
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  • [Title] Radical resection for craniopharyngiomas in children: surgical technique and clinical results.
  • Craniopharyngiomas are benign suprasellar tumors; however, their tendency to recur after resection and the risks associated with aggressive tumor resection pose a surgical dilemma.
  • We reviewed our series of operated craniopharyngiomas and selected pediatric cases operated as first-hand cases and followed in our institution.
  • Tumor progression occurred in 93% of cases after subtotal resection versus 43% after total resection.
  • Visual deficits were often stabilized or improved after surgery, but worsened in 30% because of surgical damage or tumor recurrence.
  • All patients have some degree of pituitary hormonal replacement and 48% have obesity.
  • Hypothalamic damage was generally associated with intraventricular extension of the tumor recurrence and re-operations, especially through combined approaches.
  • Craniopharyngiomas in children are particularly aggressive tumors.
  • [MeSH-major] Craniopharyngioma / surgery. Neurosurgical Procedures / methods. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Combined Modality Therapy. Female. Hormone Replacement Therapy. Humans. Male. Neoplasm Recurrence, Local / therapy. Neuropsychological Tests. Postoperative Care. Radiosurgery. Retrospective Studies. Rhenium / therapeutic use. Tomography, X-Ray Computed. Treatment Outcome. Visual Acuity

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  • (PMID = 16700308.001).
  • [ISSN] 0334-018X
  • [Journal-full-title] Journal of pediatric endocrinology & metabolism : JPEM
  • [ISO-abbreviation] J. Pediatr. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 7440-15-5 / Rhenium
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64. Dehdashti AR, Ganna A, Witterick I, Gentili F: Expanded endoscopic endonasal approach for anterior cranial base and suprasellar lesions: indications and limitations. Neurosurgery; 2009 Apr;64(4):677-87; discussion 687-9
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  • The introduction of endoscopy to transsphenoidal surgery, with its improved illumination and wider field of view, has added significant further potential for the resection of a variety of cranial base lesions.
  • METHODS: From June 2005 to June 2007, the expanded endoscopic endonasal approach was used in 22 patients with the following pathologies: 6 craniopharyngiomas; 4 esthesioneuroblastomas; 3 giant pituitary macroadenomas; 2 suprasellar Rathke's pouch cysts; 2 angiofibromas; and 1 each of suprasellar meningioma, germinoma, ethmoidal carcinoma, adenoid cystic carcinoma, and large suprasellar arachnoid cyst.
  • RESULTS: Gross total tumor removal, as assessed by postoperative magnetic resonance imaging, was possible in the majority of patients (73%), with the exception of the craniopharyngioma group, in which only 1 lesion was completely removed.
  • Large lesions, significant lateral extension, encasement of neurovascular structures, and brain invasion in malignant lesions are considered some of the contraindications for this technique.
  • The avoidance of craniotomy and brain retraction and reduced neurovascular manipulation with less morbidity are potential advantages.
  • [MeSH-major] Brain Neoplasms / surgery. Nasal Cavity / surgery. Neuroendoscopy / methods. Neurosurgical Procedures / methods. Sella Turcica / surgery. Skull Base / surgery
  • [MeSH-minor] Adult. Aged. Craniopharyngioma / surgery. Esthesioneuroblastoma, Olfactory / surgery. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Neurofibroma / surgery. Retrospective Studies. Young Adult

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  • (PMID = 19349826.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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65. Karavitaki N, Scheithauer BW, Watt J, Ansorge O, Moschopoulos M, Llaguno AV, Wass JA: Collision lesions of the sella: co-existence of craniopharyngioma with gonadotroph adenoma and of Rathke's cleft cyst with corticotroph adenoma. Pituitary; 2008;11(3):317-23
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  • [Title] Collision lesions of the sella: co-existence of craniopharyngioma with gonadotroph adenoma and of Rathke's cleft cyst with corticotroph adenoma.
  • Most contributions include a pituitary adenoma or a cyst/cystic tumor, particularly a Rathke cleft cyst.
  • The association of craniopharyngioma with an adenoma is particularly rare.
  • Among reported cases, some have included secondary prolactin cell hyperplasia due to pituitary stalk section effect.
  • Herein, we report two collision lesions, including a gonadotroph adenoma with adamantinomatous craniopharyngioma and a corticotroph adenoma with Rathke's cleft cyst.
  • [MeSH-major] ACTH-Secreting Pituitary Adenoma / complications. Adenoma / complications. Central Nervous System Cysts / complications. Corticotrophs / pathology. Craniopharyngioma / complications. Gonadotrophs / pathology. Pituitary Neoplasms / complications. Sella Turcica / pathology

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  • (PMID = 17917812.001).
  • [ISSN] 1386-341X
  • [Journal-full-title] Pituitary
  • [ISO-abbreviation] Pituitary
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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66. Goto T, Maeshima A, Oyamada Y, Kato R: Esophageal cyst producing CA19-9 and CA125. Interact Cardiovasc Thorac Surg; 2010 Mar;10(3):448-50
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  • The patient was a 59-year-old woman in whom computed tomography revealed a posterior mediastinal cyst and ovarian cystoma at a medical check-up in March 2007.
  • She underwent left adnexectomy for ovarian cystoma in July 2008 and histopathological examination led to a diagnosis of dermoid cyst.
  • These findings led to a diagnosis of esophageal cyst.

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  • (PMID = 20008896.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / CA-125 Antigen; 0 / CA-19-9 Antigen; 0 / MUC16 protein, human; 0 / Membrane Proteins
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67. Aquilina K, O'Brien DF, Farrell MA, Bolger C: Primary cerebellopontine angle craniopharyngioma in a patient with gardner syndrome. Case report and review of the literature. J Neurosurg; 2006 Aug;105(2):330-3
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  • [Title] Primary cerebellopontine angle craniopharyngioma in a patient with gardner syndrome. Case report and review of the literature.
  • The authors report on the case of a craniopharyngioma arising in the cerebellopontine angle (CPA) in a patient with Gardner syndrome.
  • Although familial adenomatous polyposis (FAP) is associated with intracranial neoplasms, the current case is only the third reported craniopharyngioma in a patient with Gardner syndrome.
  • Two of these tumors, including that of the current case, originated in the CPA, an unusual location for craniopharyngiomas.
  • The literature concerning FAP and its associations with intracranial neoplasia, as well as the pathogenesis of craniopharyngiomas in the posterior fossa, is discussed.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Cerebellar Neoplasms / surgery. Cerebellopontine Angle / pathology. Cerebellopontine Angle / surgery. Craniopharyngioma / surgery. Gardner Syndrome / surgery
  • [MeSH-minor] Adult. Cerebellum / pathology. Cerebellum / surgery. Diagnosis, Differential. Fibroma / diagnosis. Fibroma / genetics. Fibroma / pathology. Fibroma / surgery. Humans. Magnetic Resonance Imaging. Male. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / genetics. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / surgery. Scalp / pathology. Scalp / surgery. Skin Neoplasms / diagnosis. Skin Neoplasms / genetics. Skin Neoplasms / pathology. Skin Neoplasms / surgery

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  • (PMID = 17219843.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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68. Furtado SV, Dash PK, Reddy K, Hegde AS: Budd-Chiari syndrome, ascites and shunt malfunction due to hyperosmolar hypernatremia in operated pediatric craniopharyngiomas: a red herring. Childs Nerv Syst; 2008 Sep;24(9):1051-5
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  • [Title] Budd-Chiari syndrome, ascites and shunt malfunction due to hyperosmolar hypernatremia in operated pediatric craniopharyngiomas: a red herring.
  • Complications of a chronic hypernatremic state can lead to severe morbidity and mortality.
  • CASES: The authors present two cases of craniopharyngioma who developed inferior vena cava thrombosis, Budd-Chiari syndrome, and shunt malfunction postoperatively.
  • [MeSH-major] Budd-Chiari Syndrome / etiology. Craniopharyngioma / complications. Hypernatremia / complications. Pituitary Neoplasms / complications. Ventriculoperitoneal Shunt

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  • (PMID = 18350304.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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69. Madorskiĭ SV, Parfenov AL, Voronina IA, Shovikova OA, Safin AM: [Specific features of cerebral blood flow changes after surgical removal of chiasmatic-sellar region tumors using data of transcranial duplex sonography]. Zh Vopr Neirokhir Im N N Burdenko; 2008 Jul-Sep;(3):35-41
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  • [Title] [Specific features of cerebral blood flow changes after surgical removal of chiasmatic-sellar region tumors using data of transcranial duplex sonography].
  • Aim of the study was to discover specific features of linear blood velocity in early postoperative period in patients with tumors of chiasmatic-sellar region.
  • Measurement of linear blood velocity using transcranial duplex sonography was performed in 294 patients with tumors of hypothalamo-hypophyseal area (149 suprasellar pituitary adenomas, 145 endosuprasellar, hypophyseal and ventricular craniopharyngiomas).
  • It was found that vasospasm of different severity was present in 62% cases after surgical removal of chiasmatic-sellar region tumors.
  • [MeSH-major] Adenoma / surgery. Cerebrovascular Circulation / physiology. Craniopharyngioma / surgery. Neurosurgical Procedures. Pituitary Neoplasms / surgery. Ultrasonography, Doppler, Transcranial
  • [MeSH-minor] Humans. Subarachnoid Hemorrhage / etiology. Subarachnoid Hemorrhage / physiopathology. Subarachnoid Hemorrhage / ultrasonography. Vasospasm, Intracranial / etiology. Vasospasm, Intracranial / physiopathology. Vasospasm, Intracranial / ultrasonography

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  • (PMID = 19062593.001).
  • [ISSN] 0042-8817
  • [Journal-full-title] Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko
  • [ISO-abbreviation] Zh Vopr Neirokhir Im N N Burdenko
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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70. Sievers C, Schneider HJ, Stalla GK: [The genetics of hypogonadotropic hypogonadism in the male]. MMW Fortschr Med; 2005 Nov 10;147(45):32-4, 36
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  • Underlying causes of hypogonadotropic hypogonadism are acquired or congenital disorders of the hypothalamus or pituitary (e.g. pituitary adenoma, craniopharyngioma, prior radiotherapy, trauma, severe general diseases, extreme stress, genetic mutations).
  • Where indicated, investigation of pituitary function, the use of imaging procedures, possibly an olfactory test, a GnRH stimulation test or genetic analyses may be added.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Female. Gonadotropin-Releasing Hormone / administration & dosage. Gonadotropin-Releasing Hormone / therapeutic use. Gonadotropins / administration & dosage. Gonadotropins / therapeutic use. Humans. Leptin / genetics. Male. Mutation. Olfaction Disorders / diagnosis. Olfaction Disorders / etiology. Pregnancy. Puberty, Delayed / diagnosis. Receptors, Cell Surface / genetics. Receptors, Leptin. Spermatogenesis. Testosterone / administration & dosage. Testosterone / therapeutic use. Time Factors

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  • (PMID = 16320650.001).
  • [ISSN] 1438-3276
  • [Journal-full-title] MMW Fortschritte der Medizin
  • [ISO-abbreviation] MMW Fortschr Med
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Gonadotropins; 0 / Leptin; 0 / Receptors, Cell Surface; 0 / Receptors, Leptin; 33515-09-2 / Gonadotropin-Releasing Hormone; 3XMK78S47O / Testosterone
  • [Number-of-references] 0
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71. Maruno M, Yoshimine T: [Craniopharyngioma]. Nihon Rinsho; 2005 Sep;63 Suppl 9:188-92
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  • [Title] [Craniopharyngioma].
  • [MeSH-major] Craniopharyngioma. Pituitary Neoplasms

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  • (PMID = 16201522.001).
  • [ISSN] 0047-1852
  • [Journal-full-title] Nihon rinsho. Japanese journal of clinical medicine
  • [ISO-abbreviation] Nippon Rinsho
  • [Language] jpn
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 13
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72. Saeki N, Murai H, Hasegawa Y, Horiguchi K, Hanazawa T, Fukuda K: [Endoscopic endonasal surgery for extrasellar tumors: case presentation and its future perspective]. No Shinkei Geka; 2009 Mar;37(3):229-46
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  • [Title] [Endoscopic endonasal surgery for extrasellar tumors: case presentation and its future perspective].
  • BACKGROUND AND OBJECTIVES: Endoscopic endonasal transsphenoidal surgery has been performed because of its advantages such as less invasive surgical management and more aggressive tumor removal of extrasellar lesions.
  • Today, we report endoscopic pituitary and skull base surgery in our institute.
  • In cases with meningiomas, craniopharyngiomas and giant pituitary adenomas, which needed intra-dural procedure, nasal procedures such as middle nasal conchotomy, posterior ethmoidectomy and skull base techniques such as optic canal decompression and removal of the planum sphenoidale were carried out to gain the wider operative field toward anterior skull base and lower clivus.
  • Angled endoscope attained more successful removal of tumor under direct visualization extending into the cavernous sinus (GH secreting ademomas) and lower clivus (chordoma).
  • Endonasal endoscopic pituitary surgery has resulted in less invasive transsphenoidal surgery since no postoperative nasal packing is needed and there is less dependency on lumbar drainage.
  • Although better techniques to prevent postoperative CSF leakage needs to be developed, this endoscopic pituitary surgery will become more common and will become a standard procedure.
  • Endoscopic skull base surgery has enabled more aggressive removal of extrasellar tumors with the aid of nasal and skull base techniques.
  • [MeSH-major] Adenoma / surgery. Craniopharyngioma / surgery. Meningioma / surgery. Pituitary Neoplasms / surgery

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  • (PMID = 19306643.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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73. Cáceres A: Intracavitary therapeutic options in the management of cystic craniopharyngioma. Childs Nerv Syst; 2005 Aug;21(8-9):705-18
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  • [Title] Intracavitary therapeutic options in the management of cystic craniopharyngioma.
  • BACKGROUND: Craniopharyngioma remains an entity of controversial management due to its critical anatomical relationships and its well-known recurrence tendency.
  • CONCLUSION: Overall, these newer options stand out as valid alternatives in the controversial management of these challenging tumors.
  • [MeSH-major] Craniopharyngioma / therapy. Cysts / therapy. Pituitary Neoplasms / therapy
  • [MeSH-minor] Antibiotics, Antineoplastic / therapeutic use. Bleomycin / therapeutic use. Combined Modality Therapy. Humans. Hypophysectomy / methods. Magnetic Resonance Imaging / methods. Pituitary Irradiation / methods. Radiosurgery / methods. Sella Turcica / surgery. Tomography, X-Ray Computed / methods

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  • (PMID = 16028088.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 11056-06-7 / Bleomycin
  • [Number-of-references] 75
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74. Darendeliler F, Karagiannis G, Wilton P: Headache, idiopathic intracranial hypertension and slipped capital femoral epiphysis during growth hormone treatment: a safety update from the KIGS database. Horm Res; 2007;68 Suppl 5:41-7
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  • [Title] Headache, idiopathic intracranial hypertension and slipped capital femoral epiphysis during growth hormone treatment: a safety update from the KIGS database.
  • Three potential side effects, headache, idiopathic intracranial hypertension (IIH) and slipped capital femoral epiphysis (SCFE), will be discussed.
  • The diagnostic groups were idiopathic GH deficiency (IGHD) (n = 27,690), congenital GHD (CGHD) (n = 2,547), craniopharyngioma (n = 1,155), cranial tumours (n = 2,203), Turner syndrome (TS) (n = 6,092), idiopathic short stature (ISS) (n = 5,286), small for gestational age (SGA) (n = 2,973), chronic renal insufficiency (CRI) (n = 1,753) and Prader-Willi syndrome (PWS) (n = 1,368).
  • The incidence was significantly higher in the groups of patients with craniopharyngiomas, CGHD and cranial tumours than in the other diagnostic groups (p < 0.05 for all).
  • The incidence (per 100,000 treatment years) was significantly lower in patients with IGHD (18.3) and in those children with ISS (14.5) than in the TS (84.5), cranial tumours (86.1) and craniopharyngioma groups (120.5) (p < 0.05 for all).

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  • (PMID = 18174706.001).
  • [ISSN] 1423-0046
  • [Journal-full-title] Hormone research
  • [ISO-abbreviation] Horm. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Recombinant Proteins; 12629-01-5 / Human Growth Hormone
  • [Number-of-references] 48
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75. Golshani KJ, Lalwani K, Delashaw JB, Selden NR: Modified orbitozygomatic craniotomy for craniopharyngioma resection in children. J Neurosurg Pediatr; 2009 Oct;4(4):345-52
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  • [Title] Modified orbitozygomatic craniotomy for craniopharyngioma resection in children.
  • OBJECT: In this study, the authors evaluated the efficacy and safety of modified orbitozygomatic craniotomy for resection of craniopharyngioma in children.
  • METHODS: A prospective, institutional review board-approved database was retrospectively reviewed for pediatric patients undergoing craniopharyngioma resection performed by a single surgeon.
  • RESULTS: Ten patients underwent craniopharyngioma resection surgery between July 2000 and January 2006 (4 girls and 6 boys, ages 1.5-17 years).
  • Eight patients had large tumors that significantly displaced the optic chiasm and hypothalamus.
  • One patient required a staged transsphenoidal operation to remove residual tumor in the sella turcica, and 1 patient underwent a contralateral subtemporal approach to resect a daughter lesion in the prepontine cistern.
  • CONCLUSIONS: Modified orbitozygomatic craniotomy provides excellent exposure of the suprasellar region with minimal brain retraction, allowing complete resection of craniopharyngiomas with good visual and neurological results.
  • [MeSH-major] Craniopharyngioma / surgery. Craniotomy / methods. Orbit / surgery. Pituitary Neoplasms / surgery. Zygoma / surgery
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Male. Neoplasm, Residual / diagnosis. Neoplasm, Residual / surgery. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / surgery. Postoperative Complications / etiology. Reoperation. Retrospective Studies. Skull Base / surgery. Sphenoid Sinus / surgery. Treatment Outcome

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  • (PMID = 19795966.001).
  • [ISSN] 1933-0715
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Haque MZ, Karim ME, Al-Azad S, Mahmood-uz-jahan: Role of computed tomography in the evaluation of pediatric brain tumor. Bangladesh Med Res Counc Bull; 2010 Dec;36(3):89-92
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  • [Title] Role of computed tomography in the evaluation of pediatric brain tumor.
  • A total of forty two clinically diagnosed pediatric brain tumors were studied over a period of two years.
  • The study was aimed to evaluate the efficacy of computed tomography (CT) in pre-operative diagnosis of pediatric brain tumors by correlating the imaging findings with postoperative histopathological findings.
  • In the present study, the common pediatric brain tumors were astrocytoma, medulloblastoma, craniopharyngioma and ependymoma.
  • In 18(42.9%) cases the tumors were supratentorial and in 24 (57.1%), they were infratentorial in location.
  • The findings of CT scan in different intracranial neoplasm strongly correlated with those of histopathology.
  • For craniopharyngioma the values were 85.7%, 100% and 97.7% respectively.
  • The study concludes that CT is an invaluable imaging modality in preoperative diagnosis of pediatric brain tumor due to its excellent characterization of tumors.
  • [MeSH-major] Brain Neoplasms / radiography. Tomography, X-Ray Computed

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  • (PMID = 21548545.001).
  • [ISSN] 0377-9238
  • [Journal-full-title] Bangladesh Medical Research Council bulletin
  • [ISO-abbreviation] Bangladesh Med Res Counc Bull
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Bangladesh
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77. Lee M, Kalani MY, Cheshier S, Gibbs IC, Adler JR, Chang SD: Radiation therapy and CyberKnife radiosurgery in the management of craniopharyngiomas. Neurosurg Focus; 2008;24(5):E4
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  • [Title] Radiation therapy and CyberKnife radiosurgery in the management of craniopharyngiomas.
  • OBJECT: Many benign intracranial tumors are amenable to radiotherapy treatment including meningiomas, schwannomas, pituitary tumors, and craniopharyngiomas.
  • The authors present their experience in the treatment of craniopharyngiomas in 16 patients using frameless CyberKnife stereotactic radiosurgery (SRS).
  • The authors discuss the role of radiation therapy in the management of these tumors, and more specifically, the role of CyberKnife SRS.
  • METHODS: Sixteen patients were treated for residual or recurrent craniopharyngioma between 2000 and 2007 with CyberKnife SRS at Stanford University Medical Center.
  • Tumor shrinkage was achieved in 7 of these 11 patients, and tumor control in another 3.
  • One patient had cystic enlargement of the residual tumor.
  • CONCLUSIONS: The authors' early experience with the application of CyberKnife SRS to residual or recurrent craniopharyngiomas has been positive; control or shrinkage of the tumor was achieved in 91% of patients, with no visual or neuroendocrine complications.
  • [MeSH-major] Cranial Irradiation. Craniopharyngioma / radiotherapy. Craniopharyngioma / surgery. Hypophysectomy / methods. Pituitary Neoplasms / radiotherapy. Pituitary Neoplasms / surgery. Radiosurgery
  • [MeSH-minor] Adolescent. Adult. Aged. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / surgery. Optic Nerve Diseases / etiology. Remission Induction. Retrospective Studies. Salvage Therapy. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18447743.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 55
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78. Kawamata T, Hori T, Amano K, Aihara Y, Kubo O, Okada Y: [Clinical standard of neurosurgical disorder (15) parasellar tumor including craniopharyngioma]. No Shinkei Geka; 2010 Feb;38(2):185-93
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  • [Title] [Clinical standard of neurosurgical disorder (15) parasellar tumor including craniopharyngioma].
  • [MeSH-major] Craniopharyngioma / surgery. Pituitary Neoplasms / surgery

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  • (PMID = 20166532.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 52
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79. Jeong IH, Lee JK, Moon KS, Joo SP, Kwak HJ, Kim TS, Kim JH, Kim SH: Ectopic recurrence of craniopharyngioma: a case report and review of the literature. J Neurooncol; 2006 Sep;79(2):191-5
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  • [Title] Ectopic recurrence of craniopharyngioma: a case report and review of the literature.
  • The ectopic recurrence of craniopharyngioma is a rare postoperative complication, for which there are fifteen reported cases that have been surgically verified.
  • A 12-year-old girl, who had undergone total removal of a suprasellar craniopharyngioma 4 years previously, presented with a generalized tonic-clonic seizure.
  • Magnetic resonance imaging revealed a strongly enhancing cystic tumor in the right frontal lobe, under the bone flap used for the previous craniotomy.
  • The intraoperative findings revealed that the recurrent tumor was anatomically related to the previous surgical tract, suggesting dissemination along the operative tract.
  • The histopathological features of the mass were the same as those of the previous suprasellar craniopharyngioma.
  • The case presented here and a review of the reports on the previous instances of ectopic recurrence of craniopharyngioma suggest that meticulous protection of the surgical field and careful handling of the tumor during the operation are required.
  • It should be emphasized that long-term follow-up is mandatory, even in patients who underwent a gross total removal.
  • [MeSH-major] Brain Neoplasms / pathology. Choristoma. Craniopharyngioma / pathology. Neoplasm Recurrence, Local / pathology. Neoplasm Seeding

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  • (PMID = 16850111.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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80. Shantaram M, Rao A, Aroor AR, Raja A, Rao S, Monteiro F: Assessment of total sialic acid and lipid-bound sialic acid in management of brain tumors. Ann Indian Acad Neurol; 2009 Jul;12(3):162-6
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  • [Title] Assessment of total sialic acid and lipid-bound sialic acid in management of brain tumors.
  • BACKGROUND: Glycoconjugate molecules expressed at the plasma membrane of mammalian cells have been reported to be associated with tumor progression.
  • The measurement of total sialic acid (TSA) and lipid-bound sialic acid (LBSA) in the cerebrospinal fluid (CSF) is suggested to be useful for the diagnosis of brain tumors.
  • But there are very few reports available on the serum glycoconjugate levels in patients with brain tumors.
  • OBJECTIVE: The objective of this study is to check the feasibility of using serum glycoconjugates such as TSA and LBSA as tumor markers in brain tumor patients.
  • MATERIALS AND METHODS: Colorimetric estimation of TSA using diphenylamine was done on 100 patients with intracranial tumors; follow-up study was carried out in 24 cases.
  • The LBSA fraction was isolated from the serum of 68 brain tumor patients and evaluated using phosphotungstic acid and resorcinol; follow-up study was done on 23 patients.
  • The various types of brain tumors included in this study were glioma, meningioma, and acoustic neurinoma as well as some other types such as medulloblastoma, secondary tumors, and craniopharyngioma.
  • DISCUSSION: TSA and LBSA do not have the ability to discriminate between benign and malignant brain tumors.
  • TSA and LBSA appear to be tumor markers of very limited value in patients with brain tumors.

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  • (PMID = 20174496.001).
  • [ISSN] 1998-3549
  • [Journal-full-title] Annals of Indian Academy of Neurology
  • [ISO-abbreviation] Ann Indian Acad Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2824932
  • [Keywords] NOTNLM ; Brain tumors / lipid-bound sialic acid / total sialic acid / tumor markers
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81. Gardner PA, Prevedello DM, Kassam AB, Snyderman CH, Carrau RL, Mintz AH: The evolution of the endonasal approach for craniopharyngiomas. J Neurosurg; 2008 May;108(5):1043-7
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  • [Title] The evolution of the endonasal approach for craniopharyngiomas.
  • Craniopharyngiomas have always been an extremely challenging type of tumor to treat.
  • The authors present a historical review of the literature from the introduction of the endonasal route for resection of craniopharyngiomas until the present.
  • The progression from the use of headlights, to microscopy, to endoscopy and fluoroscopy, and finally to modern intraoperative magnetic resonance-guided techniques, combined with collaboration between otolaryngologists and neurosurgeons, has provided the framework for the development of current techniques for the resection of sellar and suprasellar craniopharyngiomas.
  • [MeSH-major] Craniopharyngioma / history. Pituitary Neoplasms / history

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  • (PMID = 18447729.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article
  • [Publication-country] United States
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82. Sadeghi M, Karimi E, Hosseini SH: Dosimetric comparison of 90Y, 32P, and 186Re radiocolloids in craniopharyngioma treatments. Med Phys; 2009 Nov;36(11):5022-6
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  • [Title] Dosimetric comparison of 90Y, 32P, and 186Re radiocolloids in craniopharyngioma treatments.
  • PURPOSE: In the radionuclide treatment of some forms of brain tumors such as craniopharyngiomas, the selection of the appropriate radionuclide for therapy is a key element in treatment planning.
  • The aim was to study the influence by considering the beta-emitter radionuclide dose rate in an intracranial cyst.
  • [MeSH-major] Craniopharyngioma / radiotherapy. Radiotherapy / methods. Radiotherapy Dosage. Radiotherapy Planning, Computer-Assisted / methods

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  • (PMID = 19994512.001).
  • [ISSN] 0094-2405
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Phosphorus Radioisotopes; 0 / Radioisotopes; 0 / Yttrium Radioisotopes; 7440-15-5 / Rhenium
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83. Puget S, Grill J, Habrand JL, Sainte-Rose C: Multimodal treatment of craniopharyngioma: defining a risk-adapted strategy. J Pediatr Endocrinol Metab; 2006 Apr;19 Suppl 1:367-70
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  • [Title] Multimodal treatment of craniopharyngioma: defining a risk-adapted strategy.
  • Craniopharyngiomas remain a therapeutic challenge in terms of treatment-related morbidity.
  • The fact that they are rare, that they are histologically benign, and that anatomically they are located in a challenging area, made them worthy surgical prizes.
  • [MeSH-major] Craniopharyngioma / therapy. Pituitary Neoplasms / therapy

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  • (PMID = 16700312.001).
  • [ISSN] 0334-018X
  • [Journal-full-title] Journal of pediatric endocrinology & metabolism : JPEM
  • [ISO-abbreviation] J. Pediatr. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 15
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84. Vinchon M, Weill J, Delestret I, Dhellemmes P: Craniopharyngioma and hypothalamic obesity in children. Childs Nerv Syst; 2009 Mar;25(3):347-52
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  • [Title] Craniopharyngioma and hypothalamic obesity in children.
  • BACKGROUND AND PURPOSE: Obesity is a major concern in children treated for craniopharyngioma and is caused by hypothalamic damage.
  • In order to test this hypothesis, we decided to study obesity in craniopharyngioma and the factors related to it.
  • MATERIALS AND METHODS: We reviewed retrospectively our series of pediatric craniopharyngiomas operated since 1981.
  • No patient died because of surgery or tumor progression; two died with delay presumably because of endocrine failure.
  • Subtotal tumor resection was significantly associated with obesity at last control.
  • Reoperation for tumor recurrence was associated with a significantly higher BMI.
  • CONCLUSIONS: Our results suggest that obesity results from hypothalamic lesions caused by the tumor rather than by surgery.
  • The high rate of tumor recurrence in children, with the risk of additional damage to the hypothalamus, incites us to recommend total resection whenever it appears safe during initial surgery.
  • [MeSH-major] Craniopharyngioma / complications. Craniopharyngioma / surgery. Hypothalamus / physiopathology. Obesity / etiology. Pituitary Neoplasms / complications. Pituitary Neoplasms / surgery

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  • (PMID = 19057910.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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85. Hitier M, Hibon R, Candelier G, Guarnieri J, Moreau S, Babin E: The uses of computer-assisted surgical navigation in trans-nasal pituitary gland surgery. Rev Laryngol Otol Rhinol (Bord); 2009;130(3):151-7
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  • [Title] The uses of computer-assisted surgical navigation in trans-nasal pituitary gland surgery.
  • OBJECTIVES: To examine the use of computer-assisted surgery in transnasal pituitary gland surgery.
  • PATIENTS AND METHODS: Twenty cases of transnasal pituitary gland surgery using a computer-assisted navigation system, carried out between 2002 and 2004, were retrospectively studied.
  • The pituitary tumours included 18 macroadenomas, a microadenoma and a craniopharyngioma.
  • RESULTS: Tumour removal was complete in 50% of cases and partial, as judged by MRI 3 months after the procedure, in 45% of the cases.
  • Peroperative complications were limited to two breaches of the meninges and one peroperative hemorrhage during the excision of a macroadenoma invading the cavernous sinus, necessitating the suspension of the operation.
  • CONCLUSION: In our experience, the use of a computer-assisted system in transseptal pituitary surgery gives reliable millimetric surgical precision in the localization of vital internal anatomical structures, optimizes surgical resection and increases levels of safety.
  • [MeSH-major] Adenoma / surgery. Pituitary Neoplasms / surgery. Surgery, Computer-Assisted

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  • (PMID = 20345070.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
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86. Tena-Suck ML, Moreno-Reyes I, Rembao D, Vega R, Moreno-Jiménez S, Castillejos-López Mde J, Fernández-Plata R, Martínez-Briseño D, Salinas-Lara C: [Clinical pathological study of craniopharyngioma. Fifteen years at the National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez"]. Gac Med Mex; 2009 Sep-Oct;145(5):361-8
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  • [Title] [Clinical pathological study of craniopharyngioma. Fifteen years at the National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez"].
  • [Transliterated title] Craneofaringioma, estudio clínico-patológico. Quince años del Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez".
  • BACKGROUND: Craniopharyngioma is a sellar region benign cyst It's frequency ranges from 1.2% to 4.6% of all brain tumors.
  • OBJECTIVE: To carry out a clinical pathological correlation of craniopharyngioma among adults and describe the tumor's biological characteristics.
  • METHODS: We included 115 craniopharyngiomas; 100 were adamantimomatous and 15 were papillary type.
  • The mean patient age for recurrent tumors was 50.46+/-14.13yrs and 48.65+/-11.95 for non recurrent tumors.
  • Follow-up was longer among females than males and in suprasellar tumor location, papillary type, external epithelium cysts and laxo stellate reticulum.
  • CONCLUSIONS: However a good prognostic factor in craniopharyngiomas was observed in older female patients with complete exeresis, small tumors, external epithelium cysts, edematous stroma, inflammation, and absence of atypical cell and mitosis.
  • [MeSH-major] Craniopharyngioma / pathology. Pituitary Neoplasms / pathology

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  • (PMID = 20073441.001).
  • [ISSN] 0016-3813
  • [Journal-full-title] Gaceta médica de México
  • [ISO-abbreviation] Gac Med Mex
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
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87. Caldarelli M, Massimi L, Tamburrini G, Cappa M, Di Rocco C: Long-term results of the surgical treatment of craniopharyngioma: the experience at the Policlinico Gemelli, Catholic University, Rome. Childs Nerv Syst; 2005 Aug;21(8-9):747-57
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  • [Title] Long-term results of the surgical treatment of craniopharyngioma: the experience at the Policlinico Gemelli, Catholic University, Rome.
  • BACKGROUND: Craniopharyngioma (CP) is the most common intracranial non-glial tumour observed in pediatric age.
  • Although histologically benign and amenable to surgical treatment, its location and relation with vital nervous and vascular structures makes the feasibility of a radical resection difficult even in the microneurosurgery era.
  • Beside the difficulties experienced when performing tumour resection, post-operative complications, such as endocrinological imbalance, represent another point that makes CP total excision a challenge.
  • In order to avoid such complications, some authors have suggested to renounce to radical resection and to rely on post-operative radiation therapy to minimise the risk of residual tumour progression.
  • The most common presenting signs were related to endocrinological imbalance (35 cases), increased intracranial pressure (32 cases), and to a lesser extent, visual compromise (17 cases).
  • The tumour was managed by means of a single surgical approach in 47 cases and with a two-stage operation in the remaining five cases.
  • In 11 cases of intrasellar or intra/suprasellar midline location, the first surgical approach was done through the transsphenoidal route (which represented the first step of a staged operation in five instances); in the remaining 41 patients, craniotomy was the first surgical procedure.
  • Radical tumour resection was achieved in 40 cases, subtotal (only small tumour remnants adherent to the carotid arteries, 3rd ventricle floor or visual pathways) in nine, and only partial in the remaining three cases RESULTS: Histology demonstrated the adamantinous variant in all cases.
  • Nine recurrences occurred 1-8 years after surgery (three true recurrences, and six re-growths of incompletely resected tumours) that required re-operation.
  • Twelve patients underwent radiotherapy, six after an initially incomplete tumour resection and six following relapse.
  • Although not insignificant, post-operative mortality and morbidity do not seem to represent a major contraindication in attempting a radical tumour resection whenever possible.
  • [MeSH-major] Craniopharyngioma / surgery. Pituitary Neoplasms / surgery. Treatment Outcome

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  • (PMID = 15995885.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Germany
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88. Chang CV, Nunes Vdos S, Felicio AC, Zanini MA, Cunha-Neto MB, de Castro AV: Mixed germ cell tumor of the pituitary-hypothalamic region presenting as craniopharyngioma: case report and review of the literature. Arq Bras Endocrinol Metabol; 2008 Dec;52(9):1501-4
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  • [Title] Mixed germ cell tumor of the pituitary-hypothalamic region presenting as craniopharyngioma: case report and review of the literature.
  • Craniopharyngiomas and germ cell tumors (GCT) may affect the pituitary-hypothalamic region during childhood.
  • In this article we present a 5-year-old girl with clinical and radiological findings (computer tomography calcification) that were initially considered as craniopharyngioma.
  • This case report highlights that some clinical features and radiological findings of pituitary-hypothalamic tumors may be misdiagnosed as craniopharyngioma mainly when there is a mature teratoma with cartilaginous tissue differentiation.
  • [MeSH-major] Craniopharyngioma / pathology. Hypothalamic Neoplasms / pathology. Neoplasms, Germ Cell and Embryonal / pathology. Pituitary Neoplasms / pathology
  • [MeSH-minor] Child, Preschool. Diagnosis, Differential. Female. Humans. Teratoma / pathology. Teratoma / radiography. Teratoma / surgery


89. Prabhakar H, Bithal PK, Pandia MP, Gupta MM, Rath GP: Bradycardia due to hydrogen peroxide irrigation during craniotomy for craniopharyngioma. J Clin Neurosci; 2007 May;14(5):488-90
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  • [Title] Bradycardia due to hydrogen peroxide irrigation during craniotomy for craniopharyngioma.
  • We report a 15-year-old male patient undergoing right frontal craniotomy and excision of craniopharyngioma.
  • Stimulation of the anterior hypothalamus after removal of the tumor and hydrogen peroxide irrigation may have triggered intense parasympathetic activity leading to bradycardia.
  • [MeSH-major] Bradycardia / chemically induced. Craniopharyngioma / surgery. Craniotomy / methods. Hydrogen Peroxide / adverse effects

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  • (PMID = 17336531.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] BBX060AN9V / Hydrogen Peroxide
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90. Zhou L, You C: Craniopharyngioma classification. J Neurosurg; 2009 Jul;111(1):197-9; author reply 199
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  • [Title] Craniopharyngioma classification.
  • [MeSH-major] Craniopharyngioma / classification. Craniopharyngioma / surgery. Neuroendoscopy. Pituitary Neoplasms / classification. Pituitary Neoplasms / surgery

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  • [CommentOn] J Neurosurg. 2008 Apr;108(4):715-28 [18377251.001]
  • (PMID = 19569961.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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91. Hargrave DR, Hargrave UA, Bouffet E: Quality of health information on the Internet in pediatric neuro-oncology. Neuro Oncol; 2006 Apr;8(2):175-82
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  • The Internet is now the single largest source of health information and is used by many patients and their families who are affected by childhood brain tumors.
  • To assess the quality of pediatric neuro-oncology information on the Internet, we used search engines to look for information on five common tumor types (brain stem glioma, craniopharyngioma, ependymoma, low-grade glioma, and medulloblastoma).
  • Few sites offered information in languages other than English, and readability statistics showed an average required reading level of U.S. grade 12+ (the suggested level being grades 6-8 for an adult audience).
  • [MeSH-major] Brain Neoplasms. Internet / standards. Medical Informatics / standards. Medical Oncology. Neurology


92. Al-Mefty O, Ayoubi S, Kadri PA: The petrosal approach for the resection of retrochiasmatic craniopharyngiomas. Neurosurgery; 2008 May;62(5 Suppl 2):ONS331-5; discussion ONS335-6
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  • [Title] The petrosal approach for the resection of retrochiasmatic craniopharyngiomas.
  • THE PETROSAL (PRESIGMOID transtentorial) approach has been advocated for resecting retrochiasmatic craniopharyngiomas.
  • The projection of the surgical corridor, posterior to anterior and inferior upward, is particularly valuable in dissecting the upper pole of the tumor, which projects high into the third ventricle.
  • This approach allows direct visualization for dissecting the hypothalamus and the pituitary stalk, and maintaining their blood supply and functional integrity.
  • With a web site video presentation, we demonstrate the operative nuances of the approach to these tumors.
  • We recommend this approach for patients with large and giant retrochiasmatic craniopharyngiomas.
  • [MeSH-major] Cranial Sinuses / surgery. Craniopharyngioma / surgery. Optic Chiasm / surgery. Pituitary Neoplasms / surgery

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  • (PMID = 18596512.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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93. Tabaee A, Anand VK, Brown SM, Lin JW, Schwartz TH: Algorithm for reconstruction after endoscopic pituitary and skull base surgery. Laryngoscope; 2007 Jul;117(7):1133-7
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  • [Title] Algorithm for reconstruction after endoscopic pituitary and skull base surgery.
  • STUDY DESIGN AND METHODS: Patients undergoing endoscopic skull base surgery underwent an algorithmic approach to reconstruction based on tumor location, defect size, and presence of intraoperative cerebrospinal fluid (CSF) leak.
  • RESULTS: The diagnosis in the 127 patients in this series included pituitary tumor in 70 (55%) patients, encephalocele in 16 (12.6%) patients, meningioma in 11 (8.7%) patients, craniopharyngioma in 9 (7.1%) patients, and chordoma in 6 (4.7%) patients.
  • Correlation between postoperative CSF leak and study variables revealed a statistically significant longer duration of surgery (243 vs. 178 min, P = .008) and hospitalization (12.1 vs. 4.5 days, P < .0001) and a trend toward larger tumors (mean, 3.2 vs. 2.3 cm; P = .058) in patients experiencing postoperative CSF leak.
  • [MeSH-major] Adenoma / surgery. Algorithms. Central Nervous System Cysts / surgery. Endoscopy / methods. Meningeal Neoplasms / surgery. Pituitary Neoplasms / surgery. Reconstructive Surgical Procedures / methods. Skull Base Neoplasms / surgery


94. Wong TT, Ho DM, Chang KP, Yen SH, Guo WY, Chang FC, Liang ML, Pan HC, Chung WY: Primary pediatric brain tumors: statistics of Taipei VGH, Taiwan (1975-2004). Cancer; 2005 Nov 15;104(10):2156-67
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  • [Title] Primary pediatric brain tumors: statistics of Taipei VGH, Taiwan (1975-2004).
  • BACKGROUND: The purpose of the current study was to investigate a hospital series of 986 cases of primary pediatric brain tumors in Taiwan.
  • METHODS: The authors reviewed the database of primary pediatric brain tumors in patients < 18 years of age collected in Taipei Veterans General Hospital (Taipei VGH) from 1975 to May 2004.
  • Age and gender distribution, location, and classification of brain tumors were analyzed.
  • Intracranial tumors with diagnostic imaging were included.
  • Supratentorial (including pineal-quadrigeminal) located tumors (58.3%) was predominant to infratentorial tumors (41.1%).
  • In these series, 886 patients had either histologic diagnosis (842 patients) or clinical diagnosis (44 patients).
  • The most common 5 categories of tumors were astrocytic tumors (31.1%), germ cell tumors (14.0%), medulloblastomas (13.3%), craniopharyngiomas (8.3%), and ependymal tumors (5.8%).
  • Atypical teratoid/rhabdoid tumors (AT/RTs), a rare but highly malignant tumor, were 2.1%.
  • The high incidence of primary intracranial germ cell tumors correlated with reported series from Japan and Korea.
  • For the remaining 100 patients without diagnostic classifications, the majority were most likely astrocytic tumors in brain stem.
  • CONCLUSIONS: The authors analyzed a large hospital series of primary brain tumors in children.
  • Both histologically verified and unverified tumors were recruited to avoid selective bias.
  • Although it was not a study of a population-based brain tumor registry, it could still be representative of primary pediatric brain tumors in Taiwan.
  • [MeSH-major] Brain Neoplasms / classification. Brain Neoplasms / pathology

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  • [Copyright] Copyright 2005 American Cancer Society
  • (PMID = 16220552.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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95. Gapstur R, Gross CR, Ness K: Factors associated with sleep-wake disturbances in child and adult survivors of pediatric brain tumors: a review. Oncol Nurs Forum; 2009 Nov;36(6):723-31
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  • [Title] Factors associated with sleep-wake disturbances in child and adult survivors of pediatric brain tumors: a review.
  • PURPOSE/OBJECTIVES: To identify factors associated with sleep-wake disturbances in pediatric and adult survivors (aged older than 18 years) of pediatric brain tumors.
  • The search and a personal communication with one author discovered 25 English-language research articles and case reports describing sleep-wake patterns in brain tumor survivors from 1966-2008.
  • DATA SYNTHESIS: Disease- and treatment-related factors from direct injury to the hypothalamus results in irregular melatonin secretion and low hypocretin levels.
  • This contributes to decreased daytime alertness, which remains the most reported sleep-wake disturbance in brain tumor survivors.
  • Patients with craniopharyngiomas, radiation dose more than 3,500 cGy, and younger age at time of treatment experienced more severe sleep dysfunction.
  • CONCLUSIONS: Patients with brain tumors experience a disruption of sleep-wake patterns associated with major dysfunction in the hypothalamic-pituitary axis, affecting both Process S (homeostasis) and Process C (circadian) from the Two-Process Model of Sleep Regulation.
  • Various demographic-, disease-, and treatment-related variables are involved in driving the onset of sleep disturbances.
  • IMPLICATIONS FOR NURSING: Current sleep literature has identified patterns of sleep disturbances in cross-sectional studies of brain tumor survivors.
  • [MeSH-major] Brain Neoplasms / nursing. Oncology Nursing. Pediatric Nursing. Sleep Disorders, Circadian Rhythm / nursing

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  • (PMID = 19887361.001).
  • [ISSN] 1538-0688
  • [Journal-full-title] Oncology nursing forum
  • [ISO-abbreviation] Oncol Nurs Forum
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 50
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96. Kitano M, Taneda M: Extended transsphenoidal surgery for suprasellar craniopharyngiomas: infrachiasmatic radical resection combined with or without a suprachiasmatic trans-lamina terminalis approach. Surg Neurol; 2009 Mar;71(3):290-8, discussion 298
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  • [Title] Extended transsphenoidal surgery for suprasellar craniopharyngiomas: infrachiasmatic radical resection combined with or without a suprachiasmatic trans-lamina terminalis approach.
  • BACKGROUND: An extended transsphenoidal approach allowed for direct midline exposure of the parasellar structures such as the hypothalamic-pituitary axis and the third ventricle.
  • To evaluate the capability of this approach for removal of suprasellar craniopharyngiomas, surgical outcomes were retrospectively analyzed.
  • METHODS: During a 9-year period, 20 consecutive patients with suprasellar craniopharyngioma underwent transsphenoidal tumor resection.
  • No patient had a purely intrasellar tumor, 9 had prechiasmatic tumors, 9 had retrochiasmatic tumors, and 2 had purely intraventricular tumors.
  • Visual improvement and preservation of the pituitary stalk were achieved in 84% and 95% of cases, respectively.
  • New postoperative deterioration of pituitary function occurred in about 65% of cases, and no patient resolved their preoperative hormonal disturbance after surgery.
  • Recurrence after total resection occurred in 2 (11%) patients with retrochiasmatic tumors.
  • CONCLUSIONS: Reasonable surgical results in this study suggest that the extended transsphenoidal approach is safe and effective for removal of craniopharyngiomas.
  • Although preservation of the pituitary stalk can be achieved in a high percentage of patients, postoperative endocrinopathy still remains as a significant problem after radical removal of the craniopharyngioma.
  • [MeSH-major] Craniopharyngioma / surgery. Neurosurgical Procedures / methods. Optic Chiasm. Pituitary Neoplasms / surgery. Sella Turcica
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Follow-Up Studies. Humans. Male. Middle Aged. Pituitary Gland / surgery. Postoperative Complications. Retrospective Studies. Sphenoid Bone / surgery. Young Adult

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  • (PMID = 18291485.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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97. Yamada S, Fukuhara N, Oyama K, Takeshita A, Takeuchi Y, Ito J, Inoshita N: Surgical outcome in 90 patients with craniopharyngioma: an evaluation of transsphenoidal surgery. World Neurosurg; 2010 Aug-Sep;74(2-3):320-30
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  • [Title] Surgical outcome in 90 patients with craniopharyngioma: an evaluation of transsphenoidal surgery.
  • OBJECTIVE: To analyze surgical outcomes in 90 patients with craniopharyngioma treated by standard transsphenoidal surgery (TSS) or extended transsphenoidal surgery (eTSS).
  • METHODS: From 1990-2008, 90 patients (64 adults and 26 children) underwent TSS for craniopharyngioma (34 subdiaphragmatic and 56 supradiaphragmatic).
  • RESULTS: Total tumor removal was achieved in 70 (77.8%) patients, subtotal removal was achieved in 17 (18.9%), and partial removal was achieved in 3 (3.3%).
  • Postoperative deterioration of anterior pituitary hormones developed in 31 of 47 (66.0%) patients with preoperative normal function or partial anterior pituitary loss.
  • New-onset postoperative diabetes insipidus (DI) developed in 35 of 67 (52.2%) patients.
  • Tumor recurrence was observed in seven (7.8%) patients during a mean follow-up period of 4.6 years.
  • CONCLUSIONS: Most craniopharyngiomas including the supradiaphragmatic type can be removed safely by TSS with a good outcome, although endocrine function frequently worsens after surgery.
  • [MeSH-major] Craniopharyngioma / surgery. Neurosurgical Procedures / methods. Pituitary Neoplasms / surgery. Sphenoid Bone / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Follow-Up Studies. Hormones / blood. Humans. Image Interpretation, Computer-Assisted. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local. Pituitary Gland / pathology. Postoperative Complications / mortality. Postoperative Complications / pathology. Tomography, X-Ray Computed. Treatment Outcome. Vision Disorders / etiology. Vision Tests. Vision, Ocular. Young Adult

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • [CommentIn] World Neurosurg. 2010 Aug-Sep;74(2-3):256-8 [21492550.001]
  • [CommentIn] World Neurosurg. 2010 Aug-Sep;74(2-3):254-5 [21492549.001]
  • (PMID = 21492566.001).
  • [ISSN] 1878-8769
  • [Journal-full-title] World neurosurgery
  • [ISO-abbreviation] World Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hormones
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98. Kostrzewa JP, Sunde J, Riley KO, Woodworth BA: Radiofrequency coblation decreases blood loss during endoscopic sinonasal and skull base tumor removal. ORL J Otorhinolaryngol Relat Spec; 2010;72(1):38-43
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  • [Title] Radiofrequency coblation decreases blood loss during endoscopic sinonasal and skull base tumor removal.
  • BACKGROUND/AIMS: Minimizing bleeding during transnasal resections of sinonasal tumors is imperative for optimizing visualization and decreasing complications.
  • The purpose of the present study was to determine whether radiofrequency coblation decreases blood loss during endoscopic tumor removal.
  • METHODS: Sinonasal/skull base tumors treated in 2008 with endoscopic techniques were reviewed.
  • RESULTS: Twenty-three patients (average age: 46 years) with sinonasal or skull base tumors treated with transnasal endoscopic techniques were identified.
  • The sinus/skull base tumors included were esthesioneuroblastoma (n = 6), melanoma (n = 3), squamous cell carcinoma (n = 3), inverted papilloma (n = 3), adenocarcinoma (n = 2), intracranial dermoid cyst (n = 2), adenoid cystic carcinoma (n = 1), craniopharyngioma (n = 1), fibromyxosarcoma (n = 1) and undifferentiated carcinoma (n = 1).
  • The use of the coblation device was associated with a significant decrease in all categories including EBL (350 vs. 1,000 ml; p = 0.0001), EBL per operative time (66 vs. 166 ml/h; p = 0.0001) and Wormald grade (3.3 vs. 6.4; p = 0.0001).
  • CONCLUSION: Radiofrequency coblation significantly decreased blood loss during endoscopic tumor removal and is a useful tool in the armamentarium of the endoscopic skull base surgeon.

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  • (PMID = 20299815.001).
  • [ISSN] 1423-0275
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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99. May JA, Krieger MD, Bowen I, Geffner ME: Craniopharyngioma in childhood. Adv Pediatr; 2006;53:183-209
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Craniopharyngioma in childhood.
  • In summary, much progress has been made in our understanding of childhood craniopharyngiomas.
  • These histologically benign but "geographically malignant" tumors are challenging to treat and require experienced clinicians from multiple disciplines including neurosurgery, radiology, hematology/oncology, ophthalmology, endocrinology, and general pediatrics to address the multiple issues that arise with diagnosis, treatment, and long-term follow-up of affected children.
  • The study and close observation of patients who have craniopharyngiomas may also be beneficial for our general understanding of pathophysiologic processes such as the observed "growth without growth hormone" phenomenon or the well-described and studied hypothalamic obesity phenotypes.
  • [MeSH-major] Craniopharyngioma. Pituitary Neoplasms

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  • (PMID = 17089867.001).
  • [ISSN] 0065-3101
  • [Journal-full-title] Advances in pediatrics
  • [ISO-abbreviation] Adv Pediatr
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Wnt Proteins; 9002-72-6 / Growth Hormone
  • [Number-of-references] 102
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100. Lindholm J, Nielsen EH: Craniopharyngioma: historical notes. Pituitary; 2009;12(4):352-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Craniopharyngioma: historical notes.
  • For centuries tumors have been described which today with some confidence can be diagnosed as craniopharyngiomas.
  • It was not until 1904 Erdheim described what he called 'hypophysial duct tumors', and which Cushing later gave the name craniopharyngioma.
  • The first operation for this neoplasm took place in 1909.
  • This paper presents a short survey of the accumulation of knowledge of craniopharyngiomas.
  • [MeSH-major] Craniopharyngioma / history. Pituitary Neoplasms / history

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  • (PMID = 19130248.001).
  • [ISSN] 1573-7403
  • [Journal-full-title] Pituitary
  • [ISO-abbreviation] Pituitary
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 61
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