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1. Ortega-Valin F, Caminero A: [SUNCT-type headache and Rathke's cleft cyst: a controversial relation]. Rev Neurol; 2010 Jan 16-31;50(2):84-8
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  • [Title] [SUNCT-type headache and Rathke's cleft cyst: a controversial relation].
  • [Transliterated title] Cefalea tipo SUNCT y quiste de la bolsa de Rathke: controversias sobre su relación.
  • INTRODUCTION: SUNCT is a primary headache, although in a small percentage of cases it is associated with intracranial lesions, generally in the pituitary area or in the posterior fossa.
  • CASE REPORT: A 69 years-old woman with SUNCT whose magnetic resonance imaging showed chronic bleeding in a Rathke's cleft cyst.
  • [MeSH-major] Central Nervous System Cysts / complications. Headache / etiology. Pituitary Neoplasms / complications
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging

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  • (PMID = 20112216.001).
  • [ISSN] 1576-6578
  • [Journal-full-title] Revista de neurologia
  • [ISO-abbreviation] Rev Neurol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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2. Nishimoto S, Yamawaki M, Akiyama K, Kakinuma Y, Kitamura S, Sugahara T: Severe abnormalities in the reproductive organs of mice caused by chemical substances contained in heavy oil. J Toxicol Sci; 2009 Apr;34(2):239-44
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  • In the WSF administrated group, cystoma-like formation was observed in the ovary in approximately 80% of female mice.
  • Continuous administration of WSF for 28 days resulted in continued hypertrophy of the cystoma around the ovary and atrophy in the prostate gland.
  • It is likely that the cystoma-like formation in female mice and atrophy of prostate gland in male resulted of estrogenic substances present in the WSF which might be the PAHs.
  • [MeSH-minor] Administration, Oral. Animals. Cell Line, Tumor. Chemical Fractionation. Estrogens, Non-Steroidal / analysis. Estrogens, Non-Steroidal / toxicity. Female. Genes, Reporter / drug effects. Luciferases / genetics. Luciferases / metabolism. Male. Mice. Specific Pathogen-Free Organisms. Water / chemistry

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  • (PMID = 19336982.001).
  • [ISSN] 1880-3989
  • [Journal-full-title] The Journal of toxicological sciences
  • [ISO-abbreviation] J Toxicol Sci
  • [Language] eng
  • [Publication-type] Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Complex Mixtures; 0 / Estrogens, Non-Steroidal; 0 / Fuel Oils; 0 / Water Pollutants, Chemical; 059QF0KO0R / Water; EC 1.13.12.- / Luciferases
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3. Nishizawa S, Ohta S, Oki Y: Spontaneous resolution of diabetes insipidus after pituitary stalk sectioning during surgery for large craniopharyngioma. Endocrinological evaluation and clinical implications for surgical strategy. Neurol Med Chir (Tokyo); 2006 Mar;46(3):126-34; discussion 134-5
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  • [Title] Spontaneous resolution of diabetes insipidus after pituitary stalk sectioning during surgery for large craniopharyngioma. Endocrinological evaluation and clinical implications for surgical strategy.
  • The mechanism of spontaneous resolution of diabetes insipidus (DI) was investigated after surgery for large craniopharyngioma.
  • Twenty-two adult patients (mean age 48.9 years old), who underwent surgery via the anterior interhemispheric trans-lamina terminalis approach, were divided into three groups: Group I, the entire pituitary stalk was preserved (n = 2); Group II, the stalk was dissected distally from the tumor but ultimately sacrificed (n = 9); Group III, the stalk was not identified and was sacrificed (n = 11).
  • Four patients underwent gamma-knife treatment for residual tumor or recurrence.
  • Hormonal replacement for pan-hypopituitarism and DI was necessary in Groups II and III (mean follow-up period 5.9 years).
  • DI resolved at 2.7 +/- 1.3 years after surgery in four patients in Group II, and a hypertonic saline infusion test revealed production of small amounts of intrinsic antidiuretic hormone (ADH).
  • Recovery from DI can be expected, despite permanent impairment of anterior pituitary function, if the pituitary stalk is dissected as distally as possible.
  • [MeSH-major] Craniopharyngioma / surgery. Diabetes Insipidus / surgery. Pituitary Gland / surgery. Pituitary Neoplasms / surgery


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4. Ulfarsson E, Karström A, Yin S, Girnita A, Vasilcanu D, Thoren M, Kratz G, Hillman J, Axelson M, Larsson O, Girnita L: Expression and growth dependency of the insulin-like growth factor I receptor in craniopharyngioma cells: a novel therapeutic approach. Clin Cancer Res; 2005 Jul 1;11(13):4674-80
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  • [Title] Expression and growth dependency of the insulin-like growth factor I receptor in craniopharyngioma cells: a novel therapeutic approach.
  • Craniopharyngioma is a rare benign intracranial epithelial tumor that, however, often recurs and sometimes kills the affected patients, one-third of which are children.
  • Together, these circumstances raise the question whether IGF-IR may be involved in craniopharyngioma growth.
  • To address this issue, we analyzed phenotypically well-characterized primary low-passage craniopharyngioma cell lines from nine different patients for IGF-IR expression and IGF-I dependency.
  • Taken together, our data suggest that IGF-IR may be involved in the growth of a subset of craniopharyngiomas and points to the possibility of the involvement of IGF-IR inhibitors as a treatment modality to obtain complete tumor-free conditions before growth hormone substitution.
  • [MeSH-major] Craniopharyngioma / pathology. Pituitary Neoplasms / pathology. Receptor, IGF Type 1 / biosynthesis
  • [MeSH-minor] Adolescent. Adult. Cell Proliferation / drug effects. Child. Dose-Response Relationship, Drug. Humans. Immunohistochemistry. Inhibitory Concentration 50. Insulin-Like Growth Factor I / pharmacology. Middle Aged. Phosphorylation / drug effects. Podophyllotoxin / analogs & derivatives. Podophyllotoxin / pharmacology. Tumor Cells, Cultured

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  • (PMID = 16000560.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0F35AOI227 / picropodophyllin; 67763-96-6 / Insulin-Like Growth Factor I; EC 2.7.10.1 / Receptor, IGF Type 1; L36H50F353 / Podophyllotoxin
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5. Lee CH, Seo EK, Cho YJ, Kim SJ: Large Ossified Rathke's Cleft Cyst - A Case Report and Review of the Literature -. J Korean Neurosurg Soc; 2008 Oct;44(4):256-8

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  • [Title] Large Ossified Rathke's Cleft Cyst - A Case Report and Review of the Literature -.
  • We report a rare case of symptomatic Rathke's cleft cyst with thick calcified wall.
  • Brain CT scans revealed a large cystic mass with round thick calcified wall.
  • In this case, we selected the pterional approach instead of transsphenoidal approach due to the possibility of cystic craniopharyngioma.
  • Histopathologically, it was calcified Rathke's cleft cyst with focal epithelial metaplasia.
  • This case illustrates that calcification of the suprasellar cyst does not always suggest craniopharyngioma and the calcification pattern of Rathke's cleft cyst is different from that of the craniopharyngioma.

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  • (PMID = 19096687.001).
  • [ISSN] 2005-3711
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2588325
  • [Keywords] NOTNLM ; Calcification / Rathke's cleft cyst
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6. Prevedello DM, Jagannathan J, Jane JA, Laws ER: Transsphenoidal Surgery in the Treatment of Pediatric Craniopharyngiomas 865. Neurosurgery; 2006 Aug 01;59(2):475-476

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  • [Title] Transsphenoidal Surgery in the Treatment of Pediatric Craniopharyngiomas 865.

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  • (PMID = 28180739.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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7. Sadeghi M, Karimi E, Hosseini SH: Dosimetric comparison of Y90, P32, and Re186 radiocolloids in craniopharyngioma treatments. Med Phys; 2009 Nov;36(11):5022-5026

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  • [Title] Dosimetric comparison of Y90, P32, and Re186 radiocolloids in craniopharyngioma treatments.
  • PURPOSE: In the radionuclide treatment of some forms of brain tumors such as craniopharyngiomas, the selection of the appropriate radionuclide for therapy is a key element in treatment planning.
  • The aim was to study the influence by considering the beta-emitter radionuclide dose rate in an intracranial cyst.

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  • [Copyright] © 2009 American Association of Physicists in Medicine.
  • (PMID = 28525091.001).
  • [ISSN] 2473-4209
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; 186Re / 32P / 90Y / Beta decay / Brain / Cancer / Colloids / Dosimetry / Dosimetry/exposure assessment / Gamma transitions / Gold / Monte Carlo methods / Neutron transport / Photons / Radiation treatment / Therapeutic applications, including brachytherapy / Tissues / brain / cancer / colloids / craniopharyngioma / dosimetry / phosphorus / radiation therapy / radiative transfer / radiocolloid / radioisotopes / rhenium / tumours / yttrium
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8. Stienen MN, Cadosch D, Bilz S, Hildebrandt G, Gautschi OP: [Craniopharyngioma--a "geographical malignant" tumour]. Praxis (Bern 1994); 2010 Jul 28;99(15):911-21
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  • [Title] [Craniopharyngioma--a "geographical malignant" tumour].
  • [Transliterated title] Das Kraniopharyngeom--ein "geographisch maligner" Tumor.
  • The craniopharyngioma is a rare dysontogenetic tumour that originates from either scattered cells of the craniopharyngeal duct or from metaplastically mutated anterior pituitary parenchyma cells.
  • Despite being classified as a WHO-Class-I tumour, the histologically benign craniopharyngioma may display an aggressive behaviour.
  • Like other congenital tumours, it usually becomes manifest within the first two decades of life.
  • Patients typically complain of headache and a chiasma syndrome with bitemporal hemianopsy may develop depending on tumour localisation.
  • In children, anterior pituitary insufficiency often manifests as growth restriction.
  • In cystic tumors, stereotactic cyst drainage and adjuvant radiation may be a possible alternative.
  • The prognosis is best in patients who are diagnosed early.
  • [MeSH-major] Craniopharyngioma / diagnosis. Pituitary Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Child. Combined Modality Therapy. Cranial Irradiation. Diagnosis, Differential. Female. Humans. Hypophysectomy. Magnetic Resonance Imaging. Male. Pituitary Gland / pathology. Practice Guidelines as Topic. Prognosis. Radiosurgery. Tomography, X-Ray Computed

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  • (PMID = 20715005.001).
  • [ISSN] 1661-8157
  • [Journal-full-title] Praxis
  • [ISO-abbreviation] Praxis (Bern 1994)
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 54
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9. Hashizume C, Mori Y, Kobayashi T, Shibamoto Y, Nagai A, Hayashi N: Stereotactic radiotherapy using Novalis for craniopharyngioma adjacent to optic pathways. J Neurooncol; 2010 Jun;98(2):239-47
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  • [Title] Stereotactic radiotherapy using Novalis for craniopharyngioma adjacent to optic pathways.
  • Craniopharyngioma has benign histological character.
  • However, because of proximity to optic pathways, pituitary gland, and hypothalamus, it may cause severe and permanent damage to such critical structures and can even be life threatening.
  • This study aims to evaluate treatment results of Novalis stereotactic radiotherapy (SRT) for craniopharyngioma adjacent to optic pathways.
  • Ten patients (six men, four women) with craniopharyngioma and median age of 56.5 years (range 10-74 years) were treated by SRT using Novalis from July 2006 through March 2009.
  • Median volume of tumor was 7.9 ml (range 1.1-21 ml).
  • SRT for craniopharyngioma may be a safe and effective treatment.
  • Longer follow-up is necessary to determine long-term tumor control or late complications.
  • [MeSH-major] Craniopharyngioma / surgery. Optic Nerve Diseases / surgery. Pituitary Neoplasms / surgery. Radiosurgery / methods

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  • (PMID = 20422439.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Kakizawa H, Toyota N, Hieda M, Hirai N, Tachikake T, Matsuura N, Fujimura Y, Kodama I, Hirata E, Hara T, Ito K: Gynecologic abscess: CT-guided percutaneous drainage. Hiroshima J Med Sci; 2006 Sep;55(3):97-100
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  • A 42-year-old woman with recurrent bilateral endometrial ovarian cystoma presented with fever and pelvic pain caused by a tubo-ovarian abscess (TOA), which was resistant to several varieties of intravenous and oral antibiotics for 2 weeks (Case 1).
  • Computed tomography (CT)-guided diagnostic aspiration for a rapid enlarged right ovarian cystoma through a transabdominal route confirmed that it had developed into a TOA.

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  • (PMID = 16995496.001).
  • [ISSN] 0018-2052
  • [Journal-full-title] Hiroshima journal of medical sciences
  • [ISO-abbreviation] Hiroshima J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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11. Goto T, Maeshima A, Oyamada Y, Kato R: Esophageal cyst producing CA19-9 and CA125. Interact Cardiovasc Thorac Surg; 2010 Mar;10(3):448-50
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  • The patient was a 59-year-old woman in whom computed tomography revealed a posterior mediastinal cyst and ovarian cystoma at a medical check-up in March 2007.
  • She underwent left adnexectomy for ovarian cystoma in July 2008 and histopathological examination led to a diagnosis of dermoid cyst.
  • These findings led to a diagnosis of esophageal cyst.

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  • (PMID = 20008896.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / CA-125 Antigen; 0 / CA-19-9 Antigen; 0 / MUC16 protein, human; 0 / Membrane Proteins
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12. Koridze LT, Dzhangidze MA: [Combined usage of duphaston and reaferon for infertility treatment in patients with endometriosis]. Georgian Med News; 2005 Nov;(128):21-4
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  • There were 114 patients under observation who suffered from endometriosis and infertility.
  • The treatment was successful among the patients who got the combination of reaferon and dufaston, the frequency of pregnancy in the study group reached 52% vs. 27.3% in the control group (p>0.05).
  • Those patients who had so called "small form" of endometriosis became pregnant in 34% cases in the study group and in 22.7% cases in the control group.
  • Patients who had endometriosal cystoma became pregnant in 18.7% in the study group, but only in 9.4% in the test group, which shows that the treatment is less effective among these categories of patients.


13. Okońska M, Birkholz D, Korpal-Szczyrska M, Adamkiewicz-Drozyńska E, Alska A, Magnuszewska H: [The evaluation of the influence of growth hormone therapy on growing process and metabolic functions in patients after treatment of craniopharyngioma]. Pediatr Endocrinol Diabetes Metab; 2010;16(1):19-24
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  • [Title] [The evaluation of the influence of growth hormone therapy on growing process and metabolic functions in patients after treatment of craniopharyngioma].
  • [Transliterated title] Ocena wpływu terapii hormonem wzrostu na przebieg wzrastania i funkcje metaboliczne u pacjentów po leczeniu craniopharyngioma.
  • INTRODUCTION: Craniopharyngioma (CP) is a tumor, which damages pituitary function because of its localization.
  • Pituitary GH-function was assessed.
  • During rGH therapy neither tumor recurrence nor severe side effects were observed.
  • [MeSH-major] Craniopharyngioma / complications. Growth Disorders / drug therapy. Human Growth Hormone / therapeutic use. Pituitary Neoplasms / complications

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  • (PMID = 20529601.001).
  • [ISSN] 2081-237X
  • [Journal-full-title] Pediatric endocrinology, diabetes, and metabolism
  • [ISO-abbreviation] Pediatr Endocrinol Diabetes Metab
  • [Language] pol
  • [Publication-type] Clinical Trial; English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Recombinant Proteins; 12629-01-5 / Human Growth Hormone
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14. Defoort-Dhellemmes S, Moritz F, Bouacha I, Vinchon M: Craniopharyngioma: ophthalmological aspects at diagnosis. J Pediatr Endocrinol Metab; 2006 Apr;19 Suppl 1:321-4
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  • [Title] Craniopharyngioma: ophthalmological aspects at diagnosis.
  • AIM: We studied ophthalmological signs at diagnosis in children with craniopharyngioma.
  • RESULTS: Visual signs were present at diagnosis in 96% of patients in our series, but were the circumstances of diagnosis of craniopharyngioma in only 34.5%.
  • Loss of visual acuity was present at diagnosis in 15 patients (51.7%), strabismus in eight (27.6%), papilloedema in ten (34.4%), and optic nerve atrophy in 11 patients (37.9%).
  • A visual field defect was present at diagnosis in all 18 children who were able to perform an instrumental visual field and in three of the children who were tested by attraction visual field.
  • CONCLUSIONS: In children, ophthalmological signs are not the main circumstance of diagnosis of craniopharyngioma because children do not complain of a mild or unilateral reduction in visual acuity.
  • Because of the infiltrating nature of craniopharyngiomas, visual field defects are sometimes atypical and do not indicate a chiasmal problem.
  • [MeSH-major] Craniopharyngioma / complications. Eye Diseases / etiology. Pituitary Neoplasms / complications

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  • (PMID = 16700306.001).
  • [ISSN] 0334-018X
  • [Journal-full-title] Journal of pediatric endocrinology & metabolism : JPEM
  • [ISO-abbreviation] J. Pediatr. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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15. Mottolese C, Szathmari A, Berlier P, Hermier M: Craniopharyngiomas: our experience in Lyon. Childs Nerv Syst; 2005 Aug;21(8-9):790-8
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  • [Title] Craniopharyngiomas: our experience in Lyon.
  • OBJECTIVE: We reviewed our experience in surgical treatment of craniopharyngiomas.
  • Surgical treatment of craniopharyngiomas in children represents a challenge for neurosurgeons because it presents a different set of surgical problems.
  • All patients presented ante-pituitary insufficiency and diabetes insipidus, which required substitutive treatment.
  • In the group treated with bleomycin, 18 patients presented a primary cystic or a mixed form of craniopharyngioma and six patients showed a cystic recurrence.
  • In cases of cystic craniopharyngiomas, we considered bleomycin as the treatment of choice.
  • [MeSH-major] Craniopharyngioma / surgery. Cysts / surgery. Pituitary Neoplasms / surgery

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  • (PMID = 15971075.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 46
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16. Okada T, Fujitsu K, Miyahara K, Ichikawa T, Takemoto Y, Niino H, Yagishita S, Shiina T: Ciliated craniopharyngioma--case report and pathological study. Acta Neurochir (Wien); 2010 Feb;152(2):303-6; discussion 307
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  • [Title] Ciliated craniopharyngioma--case report and pathological study.
  • BACKGROUND: Craniopharyngioma has two subtypes: adamantinomatous and squamous-papillary.
  • Squamous-papillary craniopharyngioma may develop from remnants of the craniopharyngeal duct, anterior pituitary cells with squamous metaplasia, suprasellar epidermoid cyst, or Rathke cleft cyst.
  • AIM: While ciliated craniopharyngioma is considered to represent a transitional stage between Rathke cleft cyst and squamous-papillary craniopharyngioma, ciliated craniopharyngioma following Rathke cleft cyst at the same site has not previously been described.
  • RESULTS: We report a case of ciliated craniopharyngioma developing from Rathke cleft cyst.
  • CONCLUSION: The clinical course for this case is discussed together with a review of the pathological literature for ciliated craniopharyngioma.
  • [MeSH-major] Central Nervous System Cysts / complications. Central Nervous System Cysts / pathology. Craniopharyngioma / etiology. Craniopharyngioma / pathology. Pituitary Gland / pathology. Pituitary Neoplasms / pathology
  • [MeSH-minor] Cell Transformation, Neoplastic / pathology. Cerebrospinal Fluid Rhinorrhea / etiology. Cerebrospinal Fluid Rhinorrhea / pathology. Cerebrospinal Fluid Rhinorrhea / surgery. Cilia / pathology. Craniotomy. Epithelial Cells / pathology. Hemianopsia / etiology. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / prevention & control. Neoplasm Recurrence, Local / surgery. Neurosurgical Procedures. Optic Chiasm / pathology. Pituitary Hormones / blood. Pituitary Hormones / secretion. Postoperative Complications / etiology. Postoperative Complications / pathology. Postoperative Complications / surgery. Reoperation. Sella Turcica / pathology. Treatment Outcome

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  • (PMID = 19626269.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Pituitary Hormones
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17. Bahuleyan B, Menon G, Nair S: Immediate postoperative death due to hypothalamic injury following surgery for craniopharyngioma. J Clin Neurosci; 2009 Jun;16(6):850-1
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  • [Title] Immediate postoperative death due to hypothalamic injury following surgery for craniopharyngioma.
  • Autonomic disturbances due to hypothalamic injury that result in postoperative death are rare complications following surgery for craniopharyngioma.
  • We discuss the case of a child who died due to hypothalamic injury following radical excision of a multi-compartmental craniopharyngioma.
  • [MeSH-major] Autonomic Nervous System Diseases / etiology. Craniopharyngioma / surgery. Hypothalamus / injuries. Neurosurgical Procedures / adverse effects. Pituitary Neoplasms / surgery. Postoperative Complications / etiology


18. Banczerowski P, Bálint K, Sipos L: Temporal extradural ectopic craniopharyngioma. Case report. J Neurosurg; 2007 Jul;107(1):178-80
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  • [Title] Temporal extradural ectopic craniopharyngioma. Case report.
  • A rare case of histologically confirmed primary craniopharyngioma at an ectopic location is presented.
  • This cystic tumor, which had a small solid portion, was located extradurally at the right temporobasal region, and pyramidal bone erosion was observed.
  • The neuroimaging findings, surgical intervention, and histopathological features of the tumor are discussed.
  • The authors' hypothesis regarding the extradural location of the tumor is that mismigration of squamous epithelial cell remnants of the obliterated craniopharyngeal canal had occurred.
  • [MeSH-major] Bone Diseases / complications. Bone Diseases / pathology. Craniopharyngioma / complications. Craniopharyngioma / pathology. Pituitary Gland. Pituitary Neoplasms / pathology. Temporal Bone / pathology

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  • (PMID = 17639891.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Thompson D, Phipps K, Hayward R: Craniopharyngioma in childhood: our evidence-based approach to management. Childs Nerv Syst; 2005 Aug;21(8-9):660-8
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  • [Title] Craniopharyngioma in childhood: our evidence-based approach to management.
  • OBJECTIVES: In 1996 we published our results for treatment of childhood craniopharyngioma.
  • That study did not only reveal that there was a significant morbidity associated with our then policy of attempted radical removal followed by post-operative radiotherapy in those cases with residual disease, but also that risk factors for poor outcome could be identified based on the clinical and radiological findings at presentation.
  • As result of that study, we redefined the role of radical surgery in the treatment of craniopharyngioma and developed a new treatment strategy in an attempt to improve the quality of outcome without compromising tumour control.
  • METHODS: A detailed assessment of the treatment pathway and outcome was undertaken for children treated for craniopharyngioma in our unit from 1996 to 2004.
  • RESULTS: Forty-eight children with craniopharyngioma presented in the study period.
  • Radiotherapy was used in patients over the age of 5 years where residual tumour was present or progressed after the initial surgical intervention(s).
  • CONCLUSIONS: A treatment paradigm for childhood craniopharyngioma is presented which improves the quality of outcome without compromising tumour control.
  • [MeSH-major] Craniopharyngioma / therapy. Evidence-Based Medicine. Pituitary Neoplasms / therapy

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  • (PMID = 15959733.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Germany
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20. Albright AL, Hadjipanayis CG, Lunsford LD, Kondziolka D, Pollack IF, Adelson PD: Individualized treatment of pediatric craniopharyngiomas. Childs Nerv Syst; 2005 Aug;21(8-9):649-54
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  • [Title] Individualized treatment of pediatric craniopharyngiomas.
  • OBJECTIVE: The treatment of children with craniopharyngiomas should be individualized because of their heterogeneous clinical and radiographic characteristics.
  • METHODS: Medical records were reviewed for children with craniopharyngiomas who presented to the Children's Hospital of Pittsburgh for their initial management between 1983 and 2004.
  • Children were treated with microsurgical tumor resections (27), intracavitary irradiation with phosphorus 32 (32P) (12), and with gamma knife stereotactic radiosurgery (GKSR) (5).
  • There was no morbidity or mortality from GKSR, which achieved tumor stabilization or shrinkage in 4 of 5 cases.
  • Resections, 32P, and GKSR are complimentary treatment modalities for children with craniopharyngiomas.
  • [MeSH-major] Craniopharyngioma / therapy. Pituitary Neoplasms / therapy

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  • (PMID = 15931512.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 16
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21. Alvarez M: Craniopharyngiomas. J Neurosci Nurs; 2006 Oct;38(5):362-8
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  • [Title] Craniopharyngiomas.
  • Craniopharyngiomas are rare, benign, suprasellar brain tumors that account for 1%-3% of all intracranial tumors.
  • Pituitary gland involvement causes loss of pituitary function, which makes endocrine evaluation necessary before and after surgery.
  • Symptoms of intracranial mass effect, including visual field loss, obstructive hydrocephalus, and extraocular palsy of the cranial nerves, may occur.
  • Nurses play a major role in caring for patients with a craniopharyngioma by preventing and identifying complications, educating patients and families about the importance of long-term follow-up, and collaborating with multidisciplinary teams.
  • [MeSH-major] Craniopharyngioma. Pituitary Neoplasms

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  • (PMID = 17069265.001).
  • [ISSN] 0888-0395
  • [Journal-full-title] The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses
  • [ISO-abbreviation] J Neurosci Nurs
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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22. Bianco Ade M, Madeira LV, Rosemberg S, Shibata MK: Cortical seeding of a craniopharyngioma after craniotomy: Case report. Surg Neurol; 2006 Oct;66(4):437-40; discussion 440
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  • [Title] Cortical seeding of a craniopharyngioma after craniotomy: Case report.
  • BACKGROUND: Cortical seeding of a craniopharyngioma has been rarely reported.
  • We present a case that ectopically recurred along the tract of a previous surgical route.
  • METHODS: A 27-year-old woman presented earlier with a suprasellar craniopharyngioma.
  • A left frontotemporal craniotomy was done with subtotal resection of the tumor because it was strongly adhered to the optic chiasm.
  • Histopathology confirmed the diagnosis of craniopharyngioma.
  • Magnetic resonance imaging revealed a contrast-enhancing tumor with cystic and solid components on the left temporal lobe cortex.
  • The primary tumor bed was intact.
  • The patient was reoperated, and the temporal lobe tumor was totally removed.
  • Histologic studies showed an adamantinomatous craniopharyngioma.
  • CONCLUSIONS: Although craniopharyngiomas exhibit a benign histopathologic pattern, a total resection combined with careful inspection and irrigation of the surgical field is the optimal treatment for preventing local and ectopic recurrences.
  • [MeSH-major] Brain Neoplasms / secondary. Craniopharyngioma / secondary. Neoplasm Seeding. Pituitary Neoplasms / pathology. Temporal Lobe / pathology
  • [MeSH-minor] Adult. Craniotomy. Female. Humans. Magnetic Resonance Imaging. Neoplasm Recurrence, Local. Neurosurgical Procedures / methods. Neurosurgical Procedures / standards. Optic Chiasm / pathology. Optic Chiasm / physiopathology. Seizures / etiology. Seizures / physiopathology. Treatment Outcome. Vision, Low / etiology. Vision, Low / physiopathology

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  • (PMID = 17015135.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Pekmezci M, Louie J, Gupta N, Bloomer MM, Tihan T: Clinicopathological characteristics of adamantinomatous and papillary craniopharyngiomas: University of California, San Francisco experience 1985-2005. Neurosurgery; 2010 Nov;67(5):1341-9; discussion 1349
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  • [Title] Clinicopathological characteristics of adamantinomatous and papillary craniopharyngiomas: University of California, San Francisco experience 1985-2005.
  • BACKGROUND: Craniopharyngiomas are rare epithelial tumors that are presumed to arise from the remnants of Rathke's pouch.
  • OBJECTIVE: This study was designed to evaluate the outcome characteristics of craniopharyngiomas treated in a single institution and to determine whether the adamantinomatous craniopharyngioma should be considered more aggressive than a World Health Organization (WHO) grade I neoplasm.
  • METHODS: We identified all patients with craniopharyngioma given their diagnoses at University of California, San Francisco in a 20-year period and performed a retrospective analysis of clinicopathological and outcome characteristics.
  • Sixty-nine tumors were adamantinomatous, 9 were papillary, and 2 were unclassified.
  • All pediatric tumors were adamantinomatous.
  • During a median follow-up of 82 months, 38 tumors recurred.
  • CONCLUSION: Adamantinomatous craniopharyngioma is a locally aggressive neoplasm with a significant rate of recurrence.
  • This is not in keeping with the current designation of a WHO grade I neoplasm.
  • Given the high numbers of "silent" defects, formal visual field testing should be performed in all patients with craniopharyngiomas.
  • [MeSH-major] Craniopharyngioma / mortality. Craniopharyngioma / surgery. Neoplasm Recurrence, Local / mortality. Pituitary Neoplasms / mortality. Pituitary Neoplasms / surgery. Postoperative Complications / mortality

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  • (PMID = 20871436.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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24. Hölsken A, Buchfelder M, Fahlbusch R, Blümcke I, Buslei R: Tumour cell migration in adamantinomatous craniopharyngiomas is promoted by activated Wnt-signalling. Acta Neuropathol; 2010 May;119(5):631-9
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  • [Title] Tumour cell migration in adamantinomatous craniopharyngiomas is promoted by activated Wnt-signalling.
  • Activating beta-catenin mutations with aberrant cytoplasmic and nuclear protein accumulation are hallmarks of adamantinomatous craniopharyngiomas (adaCP).
  • These tumours tend to be associated with unfavourable and occasionally disastrous sequelae, as they invade adjacent brain structures such as the hypothalamus.
  • The tips of invading adaCP epithelium harbour cell clusters with nuclear beta-catenin accumulations, suggesting an influence of beta-catenin-dependent signal transduction on the tumour migratory capacity.
  • Tumour cell migration was significantly reduced in Boyden chamber and wound-healing experiments following siRNA treatment.
  • We further showed that fascin, a target gene of beta-catenin TCF signalling in colorectal cancer cells and a key component of filopodia, is also involved in this process. beta-Catenin accumulating tumour cells co-express fascin and fascin mRNA levels can be significantly down-regulated in adaCP cultures treated with CTNNB1 siRNA.
  • Furthermore, migration experiments showed a significantly lower cell motility of adaCP tumour cells in vitro when transfected with fascin siRNA.
  • This suggests that activated Wnt-signalling serves as a promoter of the epithelial migration machinery by regulating target molecules such as fascin in adaCP tumour cells.
  • [MeSH-major] Cell Movement / physiology. Craniopharyngioma / pathology. Pituitary Neoplasms / pathology. Signal Transduction / physiology. Wnt Proteins / genetics

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  • (PMID = 20131060.001).
  • [ISSN] 1432-0533
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / Microfilament Proteins; 0 / RNA, Small Interfering; 0 / Wnt Proteins; 0 / beta Catenin; 146808-54-0 / fascin
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25. Schmalisch K, Beschorner R, Psaras T, Honegger J: Postoperative intracranial seeding of craniopharyngiomas--report of three cases and review of the literature. Acta Neurochir (Wien); 2010 Feb;152(2):313-9; discussion 319
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  • [Title] Postoperative intracranial seeding of craniopharyngiomas--report of three cases and review of the literature.
  • PURPOSE: Seeding of craniopharyngioma has been rarely reported.
  • METHODS: The first patient was a 13-year-old boy who had initially undergone radical excision of a suprasellar and retrosellar craniopharyngioma by a right pterional approach.
  • Postoperative MRI showed no evidence of residual tumor.
  • Two years later, MRI revealed a local recurrence and in addition a separated cystic tumor on the right side adjacent to the middle cerebral artery consistent with seeding along the surgical route.
  • Both tumors were removed by re-operation.
  • On histopathological examination, both, the local recurrent tumor and the distant deposit turned out to be adamantinomatous craniopharyngiomas.
  • The second patient was a 27-year-old woman who was operated on for the first time via a right pterional and 1 year later for a recurrent craniopharyngioma via a transsphenoidal approach.
  • Two years later, MRI revealed a right fronto-lateral intracranial metastasis at the site of the former craniotomy, which was removed by re-craniotomy.
  • This deposit in the operative pathway was found to be an adamantinomatous craniopharyngioma, as was the initial tumor.
  • The third patient was a 42-year-old man who was operated on 10 years ago for the first time via a right fronto-temporal approach.
  • The recent control MRT revealed a right parietal intracranial tumor with peripheral contrast enhancement, which was located distant to the former craniotomy.
  • The tumor was removed and histopathological examination revealed an adamantinomatous craniopharyngioma in accordance with the initial tumor.
  • CONCLUSION: Although craniopharyngiomas exhibit a benign histopathological pattern, cerebrospinal fluid seeding along the surgical route or along the CSF pathways has been observed.
  • Ectopic recurrence of craniopharyngioma suggests that meticulous protection of the whole surgical field and careful handling of the tumor during the operation are required.
  • [MeSH-major] Brain Neoplasms / secondary. Craniopharyngioma / secondary. Neoplasm Metastasis / pathology. Neoplasm Seeding. Pituitary Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Craniotomy. Female. Frontal Bone / pathology. Frontal Bone / surgery. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Parietal Bone / pathology. Parietal Bone / surgery. Reoperation. Treatment Outcome

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  • (PMID = 19859655.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Austria
  • [Number-of-references] 31
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26. Golshani KJ, Lalwani K, Delashaw JB, Selden NR: Modified orbitozygomatic craniotomy for craniopharyngioma resection in children. J Neurosurg Pediatr; 2009 Oct;4(4):345-52
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  • [Title] Modified orbitozygomatic craniotomy for craniopharyngioma resection in children.
  • OBJECT: In this study, the authors evaluated the efficacy and safety of modified orbitozygomatic craniotomy for resection of craniopharyngioma in children.
  • METHODS: A prospective, institutional review board-approved database was retrospectively reviewed for pediatric patients undergoing craniopharyngioma resection performed by a single surgeon.
  • RESULTS: Ten patients underwent craniopharyngioma resection surgery between July 2000 and January 2006 (4 girls and 6 boys, ages 1.5-17 years).
  • Eight patients had large tumors that significantly displaced the optic chiasm and hypothalamus.
  • One patient required a staged transsphenoidal operation to remove residual tumor in the sella turcica, and 1 patient underwent a contralateral subtemporal approach to resect a daughter lesion in the prepontine cistern.
  • CONCLUSIONS: Modified orbitozygomatic craniotomy provides excellent exposure of the suprasellar region with minimal brain retraction, allowing complete resection of craniopharyngiomas with good visual and neurological results.
  • [MeSH-major] Craniopharyngioma / surgery. Craniotomy / methods. Orbit / surgery. Pituitary Neoplasms / surgery. Zygoma / surgery
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Male. Neoplasm, Residual / diagnosis. Neoplasm, Residual / surgery. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / surgery. Postoperative Complications / etiology. Reoperation. Retrospective Studies. Skull Base / surgery. Sphenoid Sinus / surgery. Treatment Outcome

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  • (PMID = 19795966.001).
  • [ISSN] 1933-0715
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Frangou EM, Tynan JR, Robinson CA, Ogieglo LM, Vitali AM: Metastatic craniopharyngioma: case report and literature review. Childs Nerv Syst; 2009 Sep;25(9):1143-7
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  • [Title] Metastatic craniopharyngioma: case report and literature review.
  • BACKGROUND: Distant spread of craniopharyngioma is a rare but important complication.
  • We describe a rare case of metastatic leptomeningeal craniopharyngioma as a result of dissemination along CSF pathways in a child.
  • CASE PRESENTATION: A 14-year-old male was diagnosed with metastatic craniopharyngioma on routine follow-up imaging after multiple surgeries and radiation for locally recurrent craniopharyngioma.
  • Histopathology confirmed adamantinomatous craniopharyngioma.
  • DISCUSSION: A review of reported cases suggests that leptomeningeal implantation may be an important step in metastases of craniopharyngioma, although the mechanism is poorly understood.
  • Attention to tumor spillage at the time of surgery may be important in preventing distant recurrences.
  • [MeSH-major] Brain Neoplasms. Craniopharyngioma / secondary. Neoplasm Metastasis
  • [MeSH-minor] Adolescent. Brain / pathology. Brain / surgery. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 19517118.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 39
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28. Kwon JW, Cho BK, Kim EC, Wang KC, Kim SK: Herpes simplex encephalitis after craniopharyngioma surgery. J Neurosurg Pediatr; 2008 Nov;2(5):355-8
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  • [Title] Herpes simplex encephalitis after craniopharyngioma surgery.
  • A 13-year-old girl exhibited rapid deterioration in mental status 15 days after surgery for craniopharyngioma.
  • Serial CT scanning detected progression of a low-density lesion on the left frontotemporal lobe.
  • Early diagnosis and active treatment of herpes simplex encephalitis is essential for improving prognosis and saving lives.
  • [MeSH-major] Craniopharyngioma / surgery. Encephalitis, Herpes Simplex / diagnosis. Encephalitis, Herpes Simplex / etiology. Pituitary Neoplasms / surgery. Postoperative Complications
  • [MeSH-minor] Adolescent. Antiviral Agents / therapeutic use. Early Diagnosis. Female. Humans

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  • (PMID = 18976107.001).
  • [ISSN] 1933-0707
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antiviral Agents
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29. Hofman R, Rosingh HJ: Unilateral hearing loss as primary symptom of craniopharyngioma in a six-year-old girl. J Laryngol Otol; 2008 Mar;122(3):e10
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  • [Title] Unilateral hearing loss as primary symptom of craniopharyngioma in a six-year-old girl.
  • OBJECTIVE: We report a rare case of otological presentation of craniopharyngioma.
  • METHOD: Case report and review of world literature concerning presentations of craniopharyngioma.
  • Magnetic resonance scanning revealed a massive, cystic craniopharyngioma exerting pressure on the patient's ventricular system and brainstem and also invading the internal acoustic canal.
  • Craniopharyngioma have a prevalence of 0.13-2:100,000.
  • CONCLUSION: Craniopharyngioma is a rare disease.
  • [MeSH-major] Craniopharyngioma / complications. Hearing Loss, Unilateral / etiology. Pituitary Neoplasms / complications

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  • (PMID = 18252012.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 6
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30. Choi SH, Kwon BJ, Na DG, Kim JH, Han MH, Chang KH: Pituitary adenoma, craniopharyngioma, and Rathke cleft cyst involving both intrasellar and suprasellar regions: differentiation using MRI. Clin Radiol; 2007 May;62(5):453-62
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  • [Title] Pituitary adenoma, craniopharyngioma, and Rathke cleft cyst involving both intrasellar and suprasellar regions: differentiation using MRI.
  • AIMS: To determine the differential magnetic resonance imaging (MRI) features of pituitary adenoma, craniopharyngioma, and Rathke cleft cyst involving both intrasellar and suprasellar regions.
  • MATERIALS AND METHODS: The MRI images of 64 patients with pituitary adenoma (n=38), craniopharyngioma (n=13), or Rathke cleft cyst (n=13) were retrospectively reviewed by three neuroradiologists.
  • The following characteristics were evaluated: shape, volume, extent, component characteristics, signal intensities of solid portions on T2-weighted images, signal intensities of cystic portions on T1-weighted images, and enhancement patterns of solid portions and cyst walls of tumours.
  • A flowchart for differential diagnosis was constructed based on statistical analysis of the results.
  • RESULTS: A snowman shape, solid characteristics, and homogeneous enhancement of the solid portion were more common in pituitary adenomas (p<0.017).
  • A superiorly lobulated shape, third ventricle compression by superior tumour extension, mixed solid and cystic characteristics, and reticular enhancement of the solid portion were more common in craniopharyngiomas (p<0.017).
  • Finally, an ovoid shape, a small tumour volume, cystic characteristics, and no or thin cyst wall enhancement were more common in Rathke cleft cysts (p<0.017).
  • The flowchart yielded diagnostic accuracies as follows: 92.1% in pituitary adenoma; 92.3% in craniopharyngioma; 92.3% in Rathke cleft cyst; and 92.2% overall.
  • CONCLUSION: A combination of MRI findings is helpful in the differential diagnosis of the three tumours involving both intrasellar and suprasellar regions.
  • [MeSH-major] Adenoma / pathology. Central Nervous System Cysts / pathology. Craniopharyngioma / pathology. Magnetic Resonance Imaging / methods. Pituitary Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Radiology Information Systems. Retrospective Studies

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  • (PMID = 17398271.001).
  • [ISSN] 0009-9260
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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31. Masri AT, Bakri FG, Al-Hadidy AM, Musharbash AF, Al-Hussaini M: Ataxia-telangiectasia complicated by craniopharyngioma--a new observation. Pediatr Neurol; 2006 Oct;35(4):287-8
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  • [Title] Ataxia-telangiectasia complicated by craniopharyngioma--a new observation.
  • Ataxia-telangiectasia is a rare autosomal recessive neurodegenerative disorder with high incidence of malignancy including leukemias, lymphomas, and solid tumors.
  • Central nervous system tumors in ataxia telangiectasia include medulloblastomas and gliomas.
  • We describe a 13-year-old girl with ataxia telangiectasia who developed craniopharyngioma and non-Hodgkin's lymphoma.
  • To our knowledge, this is the first case of ataxia telangiectasia complicated by craniopharyngioma in the English literature.
  • [MeSH-major] Ataxia Telangiectasia / complications. Craniopharyngioma / complications. Pituitary Neoplasms / complications
  • [MeSH-minor] Adolescent. Brain / pathology. Consanguinity. Fatal Outcome. Female. Humans. Hypophysectomy. Lymphoma, Non-Hodgkin / complications. Lymphoma, Non-Hodgkin / diagnosis. Lymphoma, Non-Hodgkin / genetics. Magnetic Resonance Imaging. Neoplasms, Multiple Primary / complications. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / genetics. Neurologic Examination


32. Zona G, Spaziante R: Management of cystic craniopharyngiomas in childhood by a transsphenoidal approach. J Pediatr Endocrinol Metab; 2006 Apr;19 Suppl 1:381-8
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  • [Title] Management of cystic craniopharyngiomas in childhood by a transsphenoidal approach.
  • The transsphenoidal approach has specific indications in the management of craniopharyngiomas.
  • Usually, it is best reserved for patients with preferably cystic extra-arachnoid-infradiaphragmatic tumors with small suprasellar extension.
  • When possible, radical removal of these tumours must be the goal of surgery, but this attitude, which reduces but not eliminates the risk of relapse, has to be counterbalanced by heavy morbidity and even mortality, especially in children.
  • In this view, many neurosurgeons favour a more 'conservative' approach with subtotal removal followed by radiotherapy whose dramatic efficacy on craniopharyngiomas is well known.
  • With these premises, a transsphenoidal approach is realistically applicable to a greater number of large cystic craniopharyngiomas if the aim is not radical removal, but is to drain them into the sphenoid sinus to relieve mass effect symptoms (cystosphenoidostomy), and delay radiotherapy and its detrimental effects on visual and pituitary function, especially in younger patients, to a more suitable time after surgery.
  • [MeSH-major] Craniopharyngioma / surgery. Neurosurgical Procedures. Pituitary Neoplasms / surgery. Sphenoid Bone

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  • (PMID = 16700314.001).
  • [ISSN] 0334-018X
  • [Journal-full-title] Journal of pediatric endocrinology & metabolism : JPEM
  • [ISO-abbreviation] J. Pediatr. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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33. Cavalheiro S, Dastoli PA, Silva NS, Toledo S, Lederman H, da Silva MC: Use of interferon alpha in intratumoral chemotherapy for cystic craniopharyngioma. Childs Nerv Syst; 2005 Aug;21(8-9):719-24
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  • [Title] Use of interferon alpha in intratumoral chemotherapy for cystic craniopharyngioma.
  • OBJECTIVES: This study analyzed the intratumoral activity of interferon alpha (IFN-alpha) in the treatment of cystic craniopharyngiomas.
  • PATIENTS AND METHODS: From January 2000 to January 2004, nine patients presenting with cystic craniopharyngiomas were treated with intratumoral injection of IFN-alpha at the Pediatric Oncology Institute of the Federal University of São Paulo-Escola Paulista de Medicina.
  • In two cases, partial reduction of tumor size was observed at follow-up.
  • CONCLUSIONS: IFN-alpha proved to be an effective drug in the control of cystic craniopharyngiomas.
  • Additional studies should be carried out to determine the optimal dose of IFN-alpha in the treatment of cystic craniopharyngioma.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Craniopharyngioma / drug therapy. Cysts / drug therapy. Interferon-alpha / therapeutic use. Pituitary Neoplasms / drug therapy

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  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
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34. Marchal JC, Klein O, Thouvenot P, Bernier V, Moret C, Chastagner P: Individualized treatment of craniopharyngioma in children: ways and means. Childs Nerv Syst; 2005 Aug;21(8-9):655-9
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  • [Title] Individualized treatment of craniopharyngioma in children: ways and means.
  • BACKGROUND: Medium- and long-term prognosis of craniopharyngioma is overwhelmed by the risks of hypothalamic and visual impairment.
  • This problem has been underestimated for a long time because the major concern for the neurosurgeon was the risk of recurrences, their best prevention being thought to be complete tumour resection.
  • [MeSH-major] Craniopharyngioma / radiotherapy. Pituitary Neoplasms / radiotherapy

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  • (PMID = 15952028.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Isotopes; 7440-15-5 / Rhenium
  • [Number-of-references] 31
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35. Takahashi H, Yamaguchi F, Teramoto A: Long-term outcome and reconsideration of intracystic chemotherapy with bleomycin for craniopharyngioma in children. Childs Nerv Syst; 2005 Aug;21(8-9):701-4
Hazardous Substances Data Bank. BLEOMYCIN .

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  • [Title] Long-term outcome and reconsideration of intracystic chemotherapy with bleomycin for craniopharyngioma in children.
  • OBJECT: We first reported postoperative intratumoral chemotherapy with bleomycin for craniopharyngiomas in 1985.
  • A total of 11 pediatric patients with recurrent cystic craniopharyngioma was treated by intracystic injection of bleomycin after 1988 and followed up from 3 to 16 years.
  • This patient has never had recurrent tumor until now.
  • [MeSH-major] Antibiotics, Antineoplastic / therapeutic use. Bleomycin / therapeutic use. Craniopharyngioma / drug therapy. Cysts / drug therapy. Drug Therapy / methods. Pituitary Neoplasms / drug therapy

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  • (PMID = 15928963.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 11056-06-7 / Bleomycin
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36. Srinivasan KG, Ramprabananth S, Ushanandhini KP, Srividya S, Praveen Kumar M: Radiation-induced mineralizing microangiopathy in a case of recurrent craniopharyngioma. A case report. Neuroradiol J; 2010 Sep;23(4):412-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiation-induced mineralizing microangiopathy in a case of recurrent craniopharyngioma. A case report.
  • Mineralizing microangiopathy is a late complication of radiation-induced brain injury that occurs during the treatment of CNS malignancies in children and adults.
  • Early diagnosis of the radiation-induced brain injury helps to tailor the radiation dose and prevent further complications.
  • Here we describe an operated oatient with craniopharyngioma who underwent external beam radiotherapy.
  • The patient developed gradual loss of vision after two years and a review CT scan revealed the local recurrence of tumour with dystrophic calcification of the basal ganglia, frontal and temporal subcortical regions representing recurrent craniopharyngioma with radiation-induced mineralizing microangiopathy.

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  • (PMID = 24148629.001).
  • [ISSN] 1971-4009
  • [Journal-full-title] The neuroradiology journal
  • [ISO-abbreviation] Neuroradiol J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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37. Ishida M, Hotta M, Tsukamura A, Taga T, Kato H, Ohta S, Takeuchi Y, Nakasu S, Okabe H: Malignant transformation in craniopharyngioma after radiation therapy: a case report and review of the literature. Clin Neuropathol; 2010 Jan-Feb;29(1):2-8
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  • [Title] Malignant transformation in craniopharyngioma after radiation therapy: a case report and review of the literature.
  • OBJECTIVE: Craniopharyngioma is a benign epithelial tumor that is thought to arise from the remnant of the Rathke pouch.
  • Malignant transformation in craniopharyngioma is extremely rare.
  • Herein, we report a case of malignant transformation in craniopharyngioma after radiation therapy.
  • MATERIALS AND METHODS: Histopathological and immunohistochemical analyses were carried out for specimens of the suprasellar tumor (from three resections, with the third surgery performed after radiation therapy).
  • RESULTS: The resected tumors from the first and second surgeries comprised islands of loosely cohesive aggregates of epithelial cells, so-called stellate reticulum.
  • Accordingly, the diagnosis of malignant transformation in craniopharyngioma was made.
  • Immunohistochemical studies revealed that the p53 protein was over-expressed in the malignant component, whereas its expression was much lower in the benign component.
  • CONCLUSIONS: Similar to the ten previously reported cases of malignant transformation in craniopharyngioma, the present case occurred after radiation therapy. p53 protein overexpression was also observed in the earlier cases of malignant craniopharyngioma as well as in the present case (6/6 cases).
  • We concluded that radiation therapy and p53 mutations could be involved in malignant transformation in craniopharyngioma.
  • [MeSH-major] Brain Neoplasms / pathology. Brain Neoplasms / radiotherapy. Craniopharyngioma / pathology. Craniopharyngioma / radiotherapy. Neoplasms, Radiation-Induced / pathology
  • [MeSH-minor] Brain / pathology. Brain / radiation effects. Brain / surgery. Cell Transformation, Neoplastic. Child. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Radiotherapy / adverse effects

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  • (PMID = 20040326.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 17
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38. Park YS, Ahn JY, Kim DS, Kim TS, Kim SH: Late development of craniopharyngioma following surgery for Rathke's cleft cyst. Clin Neuropathol; 2009 May-Jun;28(3):177-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Late development of craniopharyngioma following surgery for Rathke's cleft cyst.
  • OBJECTIVE: Rathke's cleft cyst (RCC) may transform to papillary type craniopharyngioma (CP) after squamous metaplasia: this is referred to as ciliated CP.
  • We encountered a case involving a patient who had late development of adamantinomatous CP following surgery for RCC, the details of which may shed light on the histogenesis of CP in general.
  • 34 months after the initial surgery, the patient revisited our hospital for a rapidly aggravating visual disturbance and underwent neuroendoscopic biopsy and tumor removal via a bifrontal craniotomy.
  • Histologically, the tumor was shown to be an adamantinomatous CP.
  • [MeSH-major] Central Nervous System Cysts / pathology. Craniopharyngioma / pathology. Neoplasms, Second Primary / pathology. Pituitary Neoplasms / pathology

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  • (PMID = 19537134.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / beta Catenin
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39. Belen D, Er U, Yigitkanli K, Bolay H: Delayed neurotoxic complication of intracavitary bleomycin therapy for craniopharyngioma in a child who had previously undergone radiosurgery. Case report. J Neurosurg; 2007 May;106(5 Suppl):391-3
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  • [Title] Delayed neurotoxic complication of intracavitary bleomycin therapy for craniopharyngioma in a child who had previously undergone radiosurgery. Case report.
  • Local administration of bleomycin for the treatment of craniopharyngioma is occasionally associated with serious regional complications.
  • The authors report a case of a delayed neurotoxic complication associated with bleomycin treatment in a patient who had previously undergone radiosurgery.
  • A 14-year-old boy presented with a cyst recurrence of mixed-type craniopharyngioma.
  • The reason for this delayed complication could have been previous radiotherapy or hypersensitivity of the tumor capsule to the drug.
  • [MeSH-major] Antibiotics, Antineoplastic / adverse effects. Bleomycin / adverse effects. Brain Edema / chemically induced. Craniopharyngioma / drug therapy. Pituitary Neoplasms / drug therapy
  • [MeSH-minor] Adolescent. Catheters, Indwelling. Humans. Injections, Intralesional. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / drug therapy. Radiosurgery. Tomography, X-Ray Computed

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  • (PMID = 17566208.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 11056-06-7 / Bleomycin
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40. Merchant TE, Kiehna EN, Kun LE, Mulhern RK, Li C, Xiong X, Boop FA, Sanford RA: Phase II trial of conformal radiation therapy for pediatric patients with craniopharyngioma and correlation of surgical factors and radiation dosimetry with change in cognitive function. J Neurosurg; 2006 Feb;104(2 Suppl):94-102
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phase II trial of conformal radiation therapy for pediatric patients with craniopharyngioma and correlation of surgical factors and radiation dosimetry with change in cognitive function.
  • OBJECT: A Phase II trial of conformal radiation therapy (CRT) for craniopharyngioma was conducted to determine whether the irradiated volume could be safely reduced to decrease effects on cognitive function.
  • METHODS: Between July 1997 and January 2003, 28 pediatric patients (median age 7.3 +/- 4.12 years) received CRT in whom doses (54-55.8 Gy) were administered to the gross tumor volume (solid and cystic components) surrounded by a 1-cm clinical target volume margin.
  • Three patients experienced local disease progression.
  • Cognitive outcome for patients was adversely affected by the following factors: age younger than 7.4 years (p = 0.001), an interval between symptoms and diagnosis of more than 73 days (p = 0.06), more extensive surgery (p = 0.014), multiple surgical procedures (p = 0.002), diabetes insipidus (p = 0.02), hydrocephalus at diagnosis (p = 0.009), a cerebrospinal fluid shunt (p = 0.005), shunt revisions (p = 0.01), Ommaya reservoir laterality (p = 0.005), and cyst aspirations (p = 0.02).
  • The percentage of total brain, supratentorial brain, or left temporal lobe volumes receiving a dose in excess of 45 Gy had a significant impact on longitudinal IQ.
  • CONCLUSIONS: The use of CRT with a 1-cm margin for clinical target volume results in tumor control equivalent to that achieved using conventionally planned radiation therapy.
  • Surgical morbidity and a volume-receiving dose more than 45 Gy are factors affecting longitudinal IQ after CRT in patients treated for craniopharyngioma.
  • [MeSH-major] Cognition Disorders / etiology. Craniopharyngioma / radiotherapy. Pituitary Neoplasms / radiotherapy. Radiation Injuries / psychology. Radiotherapy, Conformal
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Disease Progression. Dose-Response Relationship, Radiation. Female. Humans. Intelligence. Male. Morbidity. Postoperative Complications. Psychometrics. Survival Analysis. Treatment Outcome

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  • (PMID = 16506496.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R25 CA023944; United States / NCI NIH HHS / CA / CA21765
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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41. Moon SH, Kim IH, Park SW, Kim I, Hong S, Park CI, Wang KC, Cho BK: Early adjuvant radiotherapy toward long-term survival and better quality of life for craniopharyngiomas--a study in single institute. Childs Nerv Syst; 2005 Aug;21(8-9):799-807
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  • [Title] Early adjuvant radiotherapy toward long-term survival and better quality of life for craniopharyngiomas--a study in single institute.
  • OBJECTIVES: The objective of the study is to compare survival and quality of life (QoL) by the delivery time of adjuvant radiotherapy (RT), early or late, for craniopharyngiomas.
  • Initial tumor size was the only prognostic factor (p=0.034) for progression-free survival in univariate analysis.
  • Better visual acuity or field was maintained, and diabetes insipidus was partly improved with early RT, but all were deteriorated as tumor progressed without early RT.
  • Poor QoL with late RT resulted from relapsed tumor and repeated surgery but was not associated with RT itself.
  • [MeSH-major] Craniopharyngioma / radiotherapy. Pituitary Neoplasms / radiotherapy. Quality of Life
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Disease Progression. Disease-Free Survival. Female. Follow-Up Studies. Humans. Imaging, Three-Dimensional. Infant. Male. Middle Aged. Postoperative Complications. Radiosurgery. Radiotherapy Dosage. Radiotherapy, Adjuvant / methods. Retrospective Studies. Time Factors. Treatment Outcome. Vision Disorders / etiology

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  • [Cites] J Neurosurg. 1986 Jul;65(1):22-7 [3712025.001]
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  • (PMID = 15959734.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Germany
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42. Rohrer TR, Fahlbusch R, Buchfelder M, Dörr HG: Craniopharyngioma in a female adolescent presenting with symptoms of anorexia nervosa. Klin Padiatr; 2006 Mar-Apr;218(2):67-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Craniopharyngioma in a female adolescent presenting with symptoms of anorexia nervosa.
  • BACKGROUND: Tumours of the central nervous system mostly present with neurological symptoms and signs of intracranial hypertension.
  • Several reports of cerebral tumors in adolescents outline initial symptoms of anorexia and emaciation, leading to the diagnosis of anorexia nervosa.
  • PATIENT: We report on a 15.5-year-old girl with a craniopharyngioma.
  • These symptoms had led initially to the clinical diagnoses of migraine and anorexia nervosa, since unenhanced computed tomography of the brain was normal.
  • The diagnosis of craniopharyngioma was made by repeated imaging, depicting an intrasellar and parasellar mass, which was totally removed by neurosurgery.
  • CONCLUSIONS: The reported case illustrates that the diagnosis of craniopharyngioma is often delayed due to unspecific clinical symptoms.
  • Careful evaluation of anthropometrics, ophthalmologic, and endocrine data in patients with suspected eating disorders may give additional clues to the diagnosis of a craniopharyngioma.
  • [MeSH-major] Anorexia Nervosa / diagnosis. Craniopharyngioma. Pituitary Neoplasms
  • [MeSH-minor] Adolescent. Body Mass Index. Diagnosis, Differential. Female. Follow-Up Studies. Growth Disorders / diagnosis. Growth Disorders / etiology. Humans. Time Factors. Treatment Outcome

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  • (PMID = 16506105.001).
  • [ISSN] 0300-8630
  • [Journal-full-title] Klinische Pädiatrie
  • [ISO-abbreviation] Klin Padiatr
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Germany
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43. Tajima T, Sawamura Y, Ishizu K, Tsubaki J: Two children with xanthogranuloma of the sellar region. Clin Pediatr Endocrinol; 2006;15(3):85-91

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report the cases of two Japanese children with cystic pituitary enlargement on magnetic resonance imaging (MRI) causing central diabetes insipidus (DI).
  • In the first patient, endocrinological examination demonstrated slightly impaired growth hormone and thyroid stimulating hormone secretions, but normal responses of other anterior pituitary hormones.
  • The second patient had normal basal levels of anterior pituitary hormones.
  • Transsphenoidal resection of the tumors was performed in both patients.
  • Histological analysis of the tumor sections demonstrated granulomatous tissue with cholesterol clefts, foamy macrophages, multinucleated giant cells and no epithelial component.
  • Thus, these tumors were pathologically diagnosed as xanthogranuloma of the sellar region, different from adamantinomatous craniopharyngioma.
  • Post-operatively, the two patients continue to have DI, however other hormone replacement therapy after one year of follow-up has not been required.
  • Although, to our knowledge, a clinical report of xanthogranuloma of the sellar region has not been reported at pediatric age, it would be included in the differential diagnosis of the sellar region.

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  • (PMID = 24790326.001).
  • [ISSN] 0918-5739
  • [Journal-full-title] Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology
  • [ISO-abbreviation] Clin Pediatr Endocrinol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Other-IDs] NLM/ PMC4004838
  • [Keywords] NOTNLM ; craniopharyngioma / pituitary / xanthogranuloma
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44. Pavón de Paz I, Peñalver Talavera D, Olivar Roldán J, Carlos Gómez-Angulo Giner J, Santonja Garriga C, Monereo Megías S: Sellar xanthogranuloma. Endocrinol Nutr; 2008 Feb;55(2):102-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report the case of a 16-year-old girl with a history of idiopathic precocious puberty and normal results on pituitary imaging scan.
  • Ten years later, a new cranial magnetic resonance imaging scan was performed due to worsening of episodes resembling Horton's headache and a lesion suggestive of pituitary bleeding was detected.
  • Surgical treatment and pathological study of the lesion led to the differential diagnosis between craniopharyngyoma and xanthogranuloma of the sella turcica.
  • The clinical progression of the tumor (not visualized 10 years previously), together with preservation of pituitary and visual function both before and after surgery, gross total removal of the tumor (difficult to achieve with craniopharyngioma) and the absence of recurrence provide strong support for the diagnosis of xanthogranuloma of the sella turcica.

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  • [Copyright] Copyright © 2008 Sociedad Española de Endocrinología y Nutrición. Published by Elsevier Espana. All rights reserved.
  • (PMID = 22964104.001).
  • [ISSN] 1575-0922
  • [Journal-full-title] Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición
  • [ISO-abbreviation] Endocrinol Nutr
  • [Language] eng; spa
  • [Publication-type] Journal Article
  • [Publication-country] Spain
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45. Das S, Bhansali A, Upreti V, Dutta P, Gupta SK, Ananthraman R, Walia R: A child with suprasellar mass and ascites. BMJ Case Rep; 2010;2010
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  • MRI of the brain showed a sellar and suprasellar mass suggestive of craniopharyngioma with hydrocephalus.
  • He underwent a right ventriculo-peritoneal (V-P) shunting followed by a subtotal resection of the tumour.
  • A diagnosis of cerebrospinal fluid ascites (shunt ascites) was made and he underwent ventriculo-atrial shunting.
  • [MeSH-major] Ascites / etiology. Cerebrospinal Fluid. Craniopharyngioma / diagnosis. Craniopharyngioma / surgery. Hydrocephalus / diagnosis. Hydrocephalus / surgery. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / surgery. Postoperative Complications / etiology. Ventriculoperitoneal Shunt / adverse effects

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  • [Cites] N Engl J Med. 2001 Jul 26;345(4):297-8 [11474683.001]
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  • (PMID = 22789693.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3029972
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46. Yonekawa Y: [Operative neurosurgery: personal view and historical backgrounds (7) reappraisal of approaches]. No Shinkei Geka; 2010 Nov;38(11):1031-45

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Selective extradural anterior clinoidectomy SEAC was once more discussed: 1. the origin of en bloc removal has originated, 2. meaning of an en bloc replacement, if any, and 3. further development of this procedure for low lying upper basilar aneurysms.
  • 2. Trans-sulcus circularis insulae approach TSCIA, which is a part of the selective amygdalohippocampectomy approach SAHEA was applied for removal of a ganglioglioma originating from the head of the hippocampus (cause of intractable temporal lobe epilepsy) of the dominant hemisphere without performing SAHE due to a positive selective Wada test and the full SAHEA for P2 or P2-3 junction aneurysms (Fig. 1, 2, 3).
  • 3. Trans-rostrum corporis callosi-lamina terminalis approach TRCLA revealed to be less invasive and helpful for removal of a small recurrent craniopharyngioma located between the chiasma opticum and the AcomA complex with the use of a small craniotomy, avoiding previous craniotomy routes, both pterional and subfrontal, for fear of structural adhesion (Fig. 4, 5, 6).
  • 4. Within the scope of the trans-lobulus quadrangularis approach TLQA, the paramedian supracerebellar transtentorial approach SCTTA revealed to be useful for removal of a cavernous angioma located at the parahippocampal gyrus corresponding to the head of the hippocampus of the dominant hemisphere, so that the possible impairment of cognitive function could be avoided, because the incision to the temporal stem and to the hippocampus involved in the above mentioned SAHEA could be avoided.
  • [MeSH-minor] Brain Neoplasms / surgery. Humans. Intracranial Aneurysm / surgery

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  • (PMID = 21081816.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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47. Saito N, Aoki K, Sakurai T, Ito K, Hayashi M, Hirata Y, Sato K, Harashina J, Akahata M, Iwabuchi S: Linezolid treatment for intracranial abscesses caused by methicillin-resistant Staphylococcus aureus--two case reports. Neurol Med Chir (Tokyo); 2010;50(6):515-7
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  • [Title] Linezolid treatment for intracranial abscesses caused by methicillin-resistant Staphylococcus aureus--two case reports.
  • Two patients were treated for intracranial infections involving methicillin-resistant Staphylococcus aureus (MRSA).
  • A 53-year-old woman had previously undergone 3 operations for craniopharyngioma before the age of 35 years.
  • Magnetic resonance imaging with contrast medium revealed a brain abscess caused by MRSA.
  • LZD has good CNS penetration, so should be considered for secondline antibiotic therapy for VCM-resistant intracranial MRSA infection.
  • [MeSH-major] Acetamides / administration & dosage. Brain Abscess / drug therapy. Brain Abscess / microbiology. Epidural Abscess / drug therapy. Epidural Abscess / microbiology. Methicillin-Resistant Staphylococcus aureus / drug effects. Oxazolidinones / administration & dosage. Staphylococcal Infections / drug therapy

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  • (PMID = 20587984.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Acetamides; 0 / Oxazolidinones; 0 / Protein Synthesis Inhibitors; ISQ9I6J12J / Linezolid
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48. Roth CL, Enriori PJ, Gebhardt U, Hinney A, Müller HL, Hebebrand J, Reinehr T, Cowley MA: Changes of peripheral alpha-melanocyte-stimulating hormone in childhood obesity. Metabolism; 2010 Feb;59(2):186-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We examined serum alpha-MSH in 52 otherwise healthy children with childhood obesity (Ob; mean age, 11 years; 32 girls/20 boys), 27 normal-weight children of same age, 7 additional obese patients with reduced melanocortin-4 receptor function (MC4Rmut), and 22 patients with craniopharyngioma (CP).
  • Persistently low alpha-MSH levels in CP patients are suspected to be due to pituitary or hypothalamic damage.
  • [MeSH-minor] Adolescent. Body Mass Index. Body Weight. Child. Craniopharyngioma / blood. Female. Genotype. Humans. Hydrocortisone / blood. Insulin / blood. Insulin Resistance. Leptin / blood. Male. Mutation. Pituitary Neoplasms / blood. Receptor, Melanocortin, Type 4 / genetics

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19766264.001).
  • [ISSN] 1532-8600
  • [Journal-full-title] Metabolism: clinical and experimental
  • [ISO-abbreviation] Metab. Clin. Exp.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00258453/ NCT00435734
  • [Grant] United States / NIDDK NIH HHS / DK / DK 62202; United States / NCRR NIH HHS / RR / RR 0163
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Insulin; 0 / Leptin; 0 / Receptor, Melanocortin, Type 4; 581-05-5 / alpha-MSH; WI4X0X7BPJ / Hydrocortisone
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49. Reith W: [Tumors in the region of the sella turcica]. Radiologe; 2009 Jul;49(7):624-31
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  • [Title] [Tumors in the region of the sella turcica].
  • Tumors of the pituitary gland can lead to limitation of hypophysis function (hypophysis insufficiency) or hypersecretion of different hormones (acromegaly, Cushing's syndrome, prolactinoma, TSH-secreting adenoma).
  • The optic chiasma lies in close proximity to the pituitary gland and can be compressed by tumors leading to visual disturbances (bilateral hemianopsia).
  • Tumors can be separated into hormone secreting and hormone inactive tumors, as well as into microadenoma with a diameter <10 mm and macroadenomas >10 mm.
  • A rare group of tumors of the hypophysis region are craniopharyngiomas, meningiomas, germinomas, gliomas, metastases and granulomotous inflammations, such as sarcoidosis and tuberculosis.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Pituitary Neoplasms / diagnosis. Sella Turcica / diagnostic imaging. Sella Turcica / pathology. Skull Neoplasms / diagnosis. Tomography, X-Ray Computed / methods

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  • [Cites] Clin Radiol. 2007 May;62(5):453-62 [17398271.001]
  • [Cites] Eur Radiol. 1999;9(5):918-23 [10369991.001]
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  • (PMID = 19568729.001).
  • [ISSN] 1432-2102
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 17
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50. Madorskiĭ SV, Parfenov AL, Voronina IA, Shovikova OA, Safin AM: [Specific features of cerebral blood flow changes after surgical removal of chiasmatic-sellar region tumors using data of transcranial duplex sonography]. Zh Vopr Neirokhir Im N N Burdenko; 2008 Jul-Sep;(3):35-41
MedlinePlus Health Information. consumer health - Pituitary Tumors.

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  • [Title] [Specific features of cerebral blood flow changes after surgical removal of chiasmatic-sellar region tumors using data of transcranial duplex sonography].
  • Aim of the study was to discover specific features of linear blood velocity in early postoperative period in patients with tumors of chiasmatic-sellar region.
  • Measurement of linear blood velocity using transcranial duplex sonography was performed in 294 patients with tumors of hypothalamo-hypophyseal area (149 suprasellar pituitary adenomas, 145 endosuprasellar, hypophyseal and ventricular craniopharyngiomas).
  • It was found that vasospasm of different severity was present in 62% cases after surgical removal of chiasmatic-sellar region tumors.
  • [MeSH-major] Adenoma / surgery. Cerebrovascular Circulation / physiology. Craniopharyngioma / surgery. Neurosurgical Procedures. Pituitary Neoplasms / surgery. Ultrasonography, Doppler, Transcranial
  • [MeSH-minor] Humans. Subarachnoid Hemorrhage / etiology. Subarachnoid Hemorrhage / physiopathology. Subarachnoid Hemorrhage / ultrasonography. Vasospasm, Intracranial / etiology. Vasospasm, Intracranial / physiopathology. Vasospasm, Intracranial / ultrasonography

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  • (PMID = 19062593.001).
  • [ISSN] 0042-8817
  • [Journal-full-title] Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko
  • [ISO-abbreviation] Zh Vopr Neirokhir Im N N Burdenko
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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51. Webb SM, Strasburger CJ, Mo D, Hartman ML, Melmed S, Jung H, Blum WF, Attanasio AF, HypoCCS International Advisory Board: Changing patterns of the adult growth hormone deficiency diagnosis documented in a decade-long global surveillance database. J Clin Endocrinol Metab; 2009 Feb;94(2):392-9
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  • [Title] Changing patterns of the adult growth hormone deficiency diagnosis documented in a decade-long global surveillance database.
  • Trends for change over time in diagnosis, GH stimulation test data, and IGF-I measurements were analyzed at 2-yr intervals by linear regression models, with entry year as the predictive variable.
  • RESULTS: Over the decade, there was a decrease in patients enrolled with diagnoses of pituitary adenoma (50.2 to 38.6%; P < 0.001), craniopharyngioma (13.3 to 8.4%; P = 0.005) and pituitary hemorrhage (5.8 to 2.8%; P = 0.001); increases in idiopathic GHD (13.9 to 19.3%; P < 0.001), less common diagnoses (7.4 to 15.8%; P < 0.001), and undefined/unknown diagnoses (1.3 to 8.6%; P < 0.001) were observed.
  • [MeSH-major] Databases, Factual. Growth Disorders / diagnosis. Human Growth Hormone / deficiency. Population Surveillance. Professional Practice / trends
  • [MeSH-minor] Adult. Age of Onset. Arginine / analysis. Diagnostic Techniques, Endocrine / trends. Female. Growth Hormone-Releasing Hormone / analysis. Humans. Insulin Resistance / physiology. Male. Middle Aged. Pituitary Diseases / complications. Pituitary Diseases / diagnosis

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  • (PMID = 19001512.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 12629-01-5 / Human Growth Hormone; 9034-39-3 / Growth Hormone-Releasing Hormone; 94ZLA3W45F / Arginine
  • [Investigator] Attanasio AF; Terme A; Beck-Peccoz P; Blum WF; Bouillon R; Chanson P; Kremlin-Bicêtre L; Chihara K; Clemmons DR; Cutler GB; Erfurth EM; Hartman M; Ho KY; Jung H; Kleinberg D; Lamberts SW; Melmed S; Robinson LL; Ross RJ; Shimatsu A; Strasburger CJ; Webb SM; Woodmansee W; Zimmermann A
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52. Frazier JL, Chaichana K, Jallo GI, Quiñones-Hinojosa A: Combined endoscopic and microscopic management of pediatric pituitary region tumors through one nostril: technical note with case illustrations. Childs Nerv Syst; 2008 Dec;24(12):1469-78
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  • [Title] Combined endoscopic and microscopic management of pediatric pituitary region tumors through one nostril: technical note with case illustrations.
  • MATERIALS AND METHODS: Five craniopharyngiomas, one Rathke's cleft cyst, and two pituitary tumors were treated via endonasal endoscopic-assisted microsurgery.
  • Histopathologic examination revealed lymphocytic hypophysitis in one patient with an enhancing lesion in the pituitary stalk.
  • [MeSH-major] Craniopharyngioma / surgery. Endoscopy / methods. Microsurgery / methods. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Central Nervous System Cysts / diagnosis. Central Nervous System Cysts / surgery. Child. Child, Preschool. Female. Humans. Male. Nasal Cavity. Nasal Septum / surgery. Neurosurgical Procedures / methods. Sella Turcica / surgery. Treatment Outcome. Turbinates / surgery

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  • (PMID = 18769925.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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53. Reynolds GM, Peet AC, Arvanitis TN: Generating prior probabilities for classifiers of brain tumours using belief networks. BMC Med Inform Decis Mak; 2007 Sep 18;7:27
MedlinePlus Health Information. consumer health - Childhood Brain Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Generating prior probabilities for classifiers of brain tumours using belief networks.
  • BACKGROUND: Numerous methods for classifying brain tumours based on magnetic resonance spectra and imaging have been presented in the last 15 years.
  • Generally, these methods use supervised machine learning to develop a classifier from a database of cases for which the diagnosis is already known.
  • In this work a method of generating probabilities of tumour class from anatomical location is presented.
  • METHODS: The method of "belief networks" is introduced as a means of generating probabilities that a tumour is any given type.
  • The belief networks are constructed using a database of paediatric tumour cases consisting of data collected over five decades; the problems associated with using this data are discussed.
  • To verify the usefulness of the networks, an application of the method is presented in which prior probabilities were generated and combined with a classification of tumours based solely on MRS data.
  • These can be used to generate a probability that a tumour is any given type.
  • Networks are presented for astrocytoma grades I and II, astrocytoma grades III and IV, ependymoma, pineoblastoma, primitive neuroectodermal tumour (PNET), germinoma, medulloblastoma, craniopharyngioma and a group representing rare tumours, "other".
  • Inclusion of a priori knowledge is an effective way of improving classification of brain tumours by non-invasive methods.
  • [MeSH-major] Bayes Theorem. Brain Neoplasms / classification. Decision Support Techniques. Diagnosis, Computer-Assisted. Germinoma / classification. Neuroectodermal Tumors / classification
  • [MeSH-minor] Child. Databases, Factual. Diagnosis, Differential. Humans. Magnetic Resonance Spectroscopy. Neoplasm Staging. Probability

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  • (PMID = 17877822.001).
  • [ISSN] 1472-6947
  • [Journal-full-title] BMC medical informatics and decision making
  • [ISO-abbreviation] BMC Med Inform Decis Mak
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0601327
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2040142
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54. Longatti P, Fiorindi A, Perin A, Martinuzzi A: Endoscopic anatomy of the cerebral aqueduct. Neurosurgery; 2007 Sep;61(3 Suppl):1-5; discussion 5-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • They include 21 patients with communicating normal pressure hydrocephalus, 6 patients with intraventricular hemorrhage, 5 patients with membranous obstruction of the foramen of Magendie, 5 patients with trapped fourth ventricle as evidenced after aqueductoplasty, 3 patients with colloid cysts, and 1 patient with craniopharyngioma with apparently normal aqueduct, which was navigated to aspirate small fragments of colloid and tiny clots.

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  • (PMID = 17876227.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 17
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55. Al-Brahim NY, Asa SL: My approach to pathology of the pituitary gland. J Clin Pathol; 2006 Dec;59(12):1245-53
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  • [Title] My approach to pathology of the pituitary gland.
  • The sellar region is the site of a large number of pathological entities arising from the pituitary and adjacent anatomical structures, including brain, blood vessels, nerves and meninges.
  • The surgical pathology of this area requires the accurate identification of neoplastic lesions, including pituitary adenoma and carcinoma, craniopharyngioma, neurological neoplasms, germ cell tumours, haematological malignancies and metastases, as well as non-neoplastic lesions such as cysts, hyperplasias and inflammatory disorders.
  • This review provides a practical approach to the diagnosis of pituitary specimens that are sent to the pathologist at the time of surgery.
  • The most common lesions resected surgically are pituitary adenomas.
  • The complex subclassification of pituitary adenomas is now recognised to reflect specific clinical features and genetic changes that predict targeted treatments for patients with pituitary disorders.
  • [MeSH-major] Adenoma / pathology. Pituitary Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Hyperplasia. Pituitary Gland / pathology. Prognosis

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  • (PMID = 17142570.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 56
  • [Other-IDs] NLM/ PMC1860551
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56. Teo WY, Tan HK, Goh BC, Putti TC: Postirradiation sarcoma of the sphenoid bone--a case report. Ann Acad Med Singapore; 2006 Feb;35(2):104-7
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  • INTRODUCTION: The development of secondary tumours as a result of radiation therapy is a rare but serious complication.
  • CLINICAL PICTURE: This is a case report of a 45-year-old Chinese male who developed postirradiation sarcoma of the sphenoid bone in less than 5 years after radiation therapy for Stage T3N1M0 nasopharyngeal carcinoma.
  • DISCUSSION: In the literature, the only case of postirradiation osteosarcoma of the sphenoid bone was after radiation therapy for craniopharyngioma.
  • Of about 3000 patients treated with radiotherapy for nasopharyngeal carcinoma over a 10-year period in Singapore, only 1 patient developed postirradiation tumour of the sphenoid bone.

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  • (PMID = 16565764.001).
  • [ISSN] 0304-4602
  • [Journal-full-title] Annals of the Academy of Medicine, Singapore
  • [ISO-abbreviation] Ann. Acad. Med. Singap.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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57. Chung TT, Drake WM, Evanson J, Walker D, Plowman PN, Chew SL, Grossman AB, Besser GM, Monson JP: Tumour surveillance imaging in patients with extrapituitary tumours receiving growth hormone replacement. Clin Endocrinol (Oxf); 2005 Sep;63(3):274-9
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  • [Title] Tumour surveillance imaging in patients with extrapituitary tumours receiving growth hormone replacement.
  • In most cases, AO-GHD arises as a result of pituitary/peripituitary tumours and/or their treatment, but the effect of GH replacement on recurrence/regrowth of these tumours is unknown.
  • The aim of this study was to examine the effect of GH replacement in a group of patients with primary tumours of the parasellar region, many of which (e.g. craniopharyngioma, glioma or germ cell tumours) might be anticipated to have a higher recurrence rate than secretory and nonsecretory anterior pituitary tumours.
  • PATIENTS AND DESIGN: We report here our experience of prospective imaging in 50 consecutive patients (21 males; mean age 45.9 years) with nonanterior pituitary parasellar tumours treated with GH.
  • The primary diagnoses were: craniopharyngioma (28), germ cell tumour (8), arachnoid cyst (4), meningioma (4), glioma (4) and mensenchymal tumour (2).
  • External pituitary irradiation had been given to 37 (74%) of patients.
  • RESULTS: Four patients had an apparent increase in tumour volume but in only one patient was it considered necessary to abandon GH replacement.
  • In two of the four cases marginal increases in cystic parasellar tumours were not progressive; and in the fourth case apparent recurrence of a suprasellar germ cell tumour was shown to be acellular fibrous tissue only on biopsy.
  • CONCLUSIONS: Overall, GH appears safe with respect to tumour recurrence over this time period in this patient group.
  • [MeSH-major] Brain / pathology. Growth Hormone / therapeutic use. Hormone Replacement Therapy. Hypopituitarism / drug therapy. Magnetic Resonance Imaging. Neoplasm Recurrence, Local / diagnosis
  • [MeSH-minor] Adult. Brain Neoplasms / complications. Brain Neoplasms / therapy. Combined Modality Therapy. Craniopharyngioma / complications. Craniopharyngioma / therapy. Female. Follow-Up Studies. Germinoma / complications. Germinoma / therapy. Glioma / complications. Glioma / therapy. Humans. Male. Middle Aged. Pituitary Irradiation

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  • (PMID = 16117814.001).
  • [ISSN] 0300-0664
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 9002-72-6 / Growth Hormone
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58. Karavitaki N: Hypopituitarism oddities: craniopharyngiomas. Horm Res; 2007;68 Suppl 5:151-3
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  • [Title] Hypopituitarism oddities: craniopharyngiomas.
  • Craniopharyngiomas are tumours associated with significant long-term pituitary dysfunction.
  • The rates of anterior pituitary hormone deficits are not influenced by treatment modality and do not differ between childhood- and adult-onset disease.
  • The apparent paradox of growth in the absence of growth hormone (GH) has been reported in children with this tumour and is not, as yet, completely understood.
  • Based on results of retrospective studies, GH therapy does not seem to increase the risk of tumour recurrence.
  • [MeSH-major] Craniopharyngioma / complications. Hypopituitarism / etiology. Pituitary Neoplasms / complications
  • [MeSH-minor] Growth Hormone / therapeutic use. Hormone Replacement Therapy. Hormones / deficiency. Humans. Neoplasm Recurrence, Local. Risk Assessment

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  • [Copyright] Copyright (c) 2007 S. Karger AG, Basel.
  • (PMID = 18174734.001).
  • [ISSN] 1423-0046
  • [Journal-full-title] Hormone research
  • [ISO-abbreviation] Horm. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Hormones; 9002-72-6 / Growth Hormone
  • [Number-of-references] 13
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59. Karavitaki N, Wass JA: Craniopharyngiomas. Endocrinol Metab Clin North Am; 2008 Mar;37(1):173-93, ix-x
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  • [Title] Craniopharyngiomas.
  • Craniopharyngiomas are epithelial tumors arising along the path of the craniopharyngeal duct and presenting with a variety of manifestations.
  • Craniopharyngiomas are associated with significant long-term morbidity and mortality rates.
  • [MeSH-major] Craniopharyngioma / pathology. Pituitary Neoplasms / pathology

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  • (PMID = 18226736.001).
  • [ISSN] 0889-8529
  • [Journal-full-title] Endocrinology and metabolism clinics of North America
  • [ISO-abbreviation] Endocrinol. Metab. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 132
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60. Jane JA Jr, Laws ER: Craniopharyngioma. Pituitary; 2006;9(4):323-6
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  • [Title] Craniopharyngioma.
  • Craniopharyngiomas are benign tumors of the parasellar region.
  • These tumors may be cystic, solid, or combinations of the two.
  • Patients may present with endocrinopathy or symptoms related to mass effect from the growing tumor.
  • The specific surgical approach must be tailored to the specific clinical situation and depends on the patient age, endocrine status, and the geometry and consistency of the tumor.
  • Whereas most solid tumors will require craniotomy or transsphenoidal surgery, some cystic tumors may be adequately managed with intracavitary therapies.
  • Subtotally resected or residual tumors often require adjuvant radiation therapy or radiosurgery.
  • [MeSH-major] Craniopharyngioma / diagnosis. Craniopharyngioma / therapy. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / therapy

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  • (PMID = 17080265.001).
  • [ISSN] 1573-7403
  • [Journal-full-title] Pituitary
  • [ISO-abbreviation] Pituitary
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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61. Sainte-Rose C, Puget S, Wray A, Zerah M, Grill J, Brauner R, Boddaert N, Pierre-Kahn A: Craniopharyngioma: the pendulum of surgical management. Childs Nerv Syst; 2005 Aug;21(8-9):691-5
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  • [Title] Craniopharyngioma: the pendulum of surgical management.
  • BACKGROUND: For a long time, craniopharyngiomas have been considered surgically attractive tumours.
  • The fact that they are rare, histologically benign, and located in a challenging (but considered accessible) area made them worthy surgical prizes.
  • METHODS: As we have saved vision and "cured" many of these tumours, the insidious and devastating effects on quality of life for these children has become evident.
  • DISCUSSION: The state-of-the-art in the surgical management of craniopharyngioma is now turning to multi-modality treatment strategies (combination surgery and radiotherapy) aiming to limit morbidity.
  • We review a series of craniopharyngiomas looking for variables that correlated with outcome as perceived in terms of quality of life and we review briefly the history of craniopharyngioma surgery and the relevant literature.
  • [MeSH-major] Craniopharyngioma / therapy. Pituitary Neoplasms / therapy. Radiotherapy / methods

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  • (PMID = 16078079.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 26
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62. Filis AK, Moon K, Cohen AR: Synchronous ventriculoscopic and microsurgical resection of complex craniopharyngiomas. Pediatr Neurosurg; 2009;45(6):434-6
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  • [Title] Synchronous ventriculoscopic and microsurgical resection of complex craniopharyngiomas.
  • BACKGROUND: Surgical resection of craniopharyngiomas may be challenging sometimes because of the size, location and tenacity.
  • The aim of this report is to discuss the usefulness of combined endoscopic and microsurgical approaches in treating complex craniopharyngiomas along with a review of the literature.
  • METHODS: A child with hydrocephalus and a large suprasellar craniopharyngioma underwent synchronous endoscopic and microsurgical resection of the lesion.
  • RESULTS: Gross total resection of the tumor was achieved.
  • CONCLUSIONS: Neuroendoscopy can complement microsurgery in approaching complex craniopharyngiomas particularly when these tumors are large and accompanied by hydrocephalus.
  • [MeSH-major] Craniopharyngioma / surgery. Microsurgery / methods. Neuroendoscopy / methods. Pituitary Neoplasms / surgery
  • [MeSH-minor] Child. Combined Modality Therapy. Contrast Media. Craniotomy / methods. Female. Follow-Up Studies. Headache / diagnosis. Headache / etiology. Humans. Magnetic Resonance Imaging / methods. Risk Assessment. Treatment Outcome. Ventriculostomy

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20110755.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 9
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63. Sadeghi M, Karimi E, Hosseini SH: Dosimetric comparison of 90Y, 32P, and 186Re radiocolloids in craniopharyngioma treatments. Med Phys; 2009 Nov;36(11):5022-6
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  • [Title] Dosimetric comparison of 90Y, 32P, and 186Re radiocolloids in craniopharyngioma treatments.
  • PURPOSE: In the radionuclide treatment of some forms of brain tumors such as craniopharyngiomas, the selection of the appropriate radionuclide for therapy is a key element in treatment planning.
  • The aim was to study the influence by considering the beta-emitter radionuclide dose rate in an intracranial cyst.
  • [MeSH-major] Craniopharyngioma / radiotherapy. Radiotherapy / methods. Radiotherapy Dosage. Radiotherapy Planning, Computer-Assisted / methods

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  • (PMID = 19994512.001).
  • [ISSN] 0094-2405
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Phosphorus Radioisotopes; 0 / Radioisotopes; 0 / Yttrium Radioisotopes; 7440-15-5 / Rhenium
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64. Garrè ML, Cama A: Craniopharyngioma: modern concepts in pathogenesis and treatment. Curr Opin Pediatr; 2007 Aug;19(4):471-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Craniopharyngioma: modern concepts in pathogenesis and treatment.
  • PURPOSE OF REVIEW: Craniopharyngioma is a benign tumour.
  • Its tendency to recur after excision and the high surgical risk due to involvement of the most vital structures of the brain mean that alternatives to radical surgery should be considered, namely limited surgical procedures followed by radiotherapy.
  • Since both options present inherent risks, optimal craniopharyngioma treatment remains controversial.
  • This paper aims to critically review the recent literature on craniopharyngioma.
  • RECENT FINDINGS: The management of children with craniopharyngioma has benefited from concerted efforts by national and international groups to improve outcome and reduce morbidity.
  • Biological markers are under investigation and this will increase our knowledge on craniopharyngioma.
  • SUMMARY: Studies on treatment, biology and pathogenesis of craniopharyngioma, available in the current literature, grew considerably in the last year.
  • Although a consensus has not been reached on all aspects of this complex disease, there is a trend in the field to move quickly towards a better understanding of the disease to improve treatment strategies and to produce clinical cooperative trials.
  • [MeSH-major] Craniopharyngioma / etiology. Craniopharyngioma / therapy. Pituitary Neoplasms / etiology. Pituitary Neoplasms / therapy

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  • (PMID = 17630614.001).
  • [ISSN] 1040-8703
  • [Journal-full-title] Current opinion in pediatrics
  • [ISO-abbreviation] Curr. Opin. Pediatr.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 58
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65. Vidal S, Scheithauer BW, Kovacs K, Lloyd RV: Angiogenesis and the growth potential of craniopharyngiomas. Endocr Pathol; 2005;16(3):219-28
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  • [Title] Angiogenesis and the growth potential of craniopharyngiomas.
  • The present study was performed to evaluate the role of neovascularization on the behavior of craniopharyngiomas as well as the contribution of endothelial cell proliferation and migration in the remodeling and expansion of the vascular network associated with angiogenesis.
  • Fourteen primary tumors were studied, all of the adamantinomatous type.
  • Immunohistochemistry demonstrated that integrin alphavbeta3 expression was restricted to tumor vasculature; the tumor cells were immunonegative.
  • More studies are needed to assess whether integrin alphavbeta3 antagonists or drugs that arrest the cell cycle of endothelial cells can inhibit angiogenesis in craniopharyngiomas.
  • [MeSH-major] Craniopharyngioma / blood supply. Neovascularization, Pathologic / pathology. Pituitary Neoplasms / blood supply
  • [MeSH-minor] Adolescent. Antigens, CD34 / metabolism. Biomarkers, Tumor / metabolism. Cell Count. Child. Child, Preschool. Female. Humans. Immunoenzyme Techniques. Integrin alphaVbeta3 / metabolism. Ki-67 Antigen / metabolism. Male. Microcirculation. Retrospective Studies

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  • (PMID = 16299405.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Integrin alphaVbeta3; 0 / Ki-67 Antigen
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66. Shirane R, Hayashi T, Tominaga T: Fronto-basal interhemispheric approach for craniopharyngiomas extending outside the suprasellar cistern. Childs Nerv Syst; 2005 Aug;21(8-9):669-78
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  • [Title] Fronto-basal interhemispheric approach for craniopharyngiomas extending outside the suprasellar cistern.
  • OBJECTIVE: The aim of the present study was to establish the usefulness of the fronto-basal approach with a relatively small craniotomy window for the removal of tumors protruding from the sellar-suprasellar region to the third and basal cistern.
  • METHOD: Forty-two patients who were surgically treated for craniopharyngiomas extending outside the sellar-suprasellar region were evaluated.
  • CONCLUSION: In our experience, the fronto-basal interhemispheric approach, even through a small craniotomy window, is a valid choice for the removal of craniopharyngiomas extending outside the sellar-suprasellar region.
  • Using this approach, tumors can be removed without significant sequelae related to surgical technique due to easy preservation of the pituitary stalk, hypothalamic structures, and perforators.
  • This approach offers a safe and minimally invasive means of treating craniopharyngiomas.
  • [MeSH-major] Craniopharyngioma / surgery. Frontal Lobe / surgery. Neurosurgical Procedures. Pituitary Neoplasms / surgery. Sella Turcica / surgery

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  • (PMID = 16034620.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Germany
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67. Sun HI, Akgun E, Bicer A, Ozkan A, Bozkurt SU, Kurtkaya O, Koc DY, Pamir MN, Kilic T: Expression of angiogenic factors in craniopharyngiomas: implications for tumor recurrence. Neurosurgery; 2010 Apr;66(4):744-50; discussion 750
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  • [Title] Expression of angiogenic factors in craniopharyngiomas: implications for tumor recurrence.
  • BACKGROUND: The primary treatment for craniopharyngiomas is total excision, but recurrence is common.
  • OBJECTIVE: We hypothesized that recurrence is linked to the angiogenesis of the tumor.
  • Recurrent and nonrecurrent tumor samples were compared with regard to expression of angiogenesis-related factors and angiogenic capacity in a corneal angiogenesis model.
  • METHODS: Specimens of 4 recurrent and 6 nonrecurrent tumors were selected from 57 patients with adamantinomatous craniopharyngiomas.
  • RESULTS: Expression of PDGFR-alpha and FGF-2 were significantly higher for recurrent tumors (P = .02 and P = .01).
  • However, recurrent and nonrecurrent tumors did not differ in the expressions of other ligands and receptors (PDGF-A, PDGF-B, and PDGFR-beta).
  • Recurrent tumors displayed a higher angiogenic potential starting from the fifth day of corneal angiogenesis assay.
  • CONCLUSION: These findings suggest a relationship between recurrence of craniopharyngiomas and angiogenesis.
  • New treatment modalities with selective PDGFR-alpha blockers may represent a novel and effective therapeutic option for the treatment of craniopharyngiomas.
  • [MeSH-major] Angiogenesis Inducing Agents / metabolism. Craniopharyngioma / metabolism. Gene Expression Regulation, Neoplastic / physiology. Neoplasm Recurrence, Local / metabolism. Pituitary Neoplasms / metabolism
  • [MeSH-minor] Adult. Animals. Cornea / metabolism. Cornea / pathology. Disease Models, Animal. Female. Fibroblast Growth Factor 2 / metabolism. Fibronectins / metabolism. Humans. Male. Middle Aged. Neoplasm Transplantation. Platelet-Derived Growth Factor / metabolism. Rats. Rats, Sprague-Dawley. Retrospective Studies. Statistics, Nonparametric. Time Factors. Vascular Endothelial Growth Factor A / metabolism. Young Adult

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  • (PMID = 20190664.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inducing Agents; 0 / Fibronectins; 0 / Platelet-Derived Growth Factor; 0 / Vascular Endothelial Growth Factor A; 103107-01-3 / Fibroblast Growth Factor 2
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68. Elliott RE, Moshel YA, Wisoff JH: Surgical treatment of ectopic recurrence of craniopharyngioma. Report of 4 cases. J Neurosurg Pediatr; 2009 Aug;4(2):105-12
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  • [Title] Surgical treatment of ectopic recurrence of craniopharyngioma. Report of 4 cases.
  • Local recurrence following radical resection is one of the most common complications of pediatric craniopharyngioma.
  • Only 28 cases of ectopic recurrence of craniopharyngioma have been reported in the literature, and only 13 cases occurred in patients originally treated as children.
  • In this consecutive series of 86 children who underwent radical resection of primary and recurrent craniopharyngiomas, 4 patients (4.7%) experienced ectopic tumor recurrence, accounting for 27% of all recurrences after gross-total resection.
  • The authors report on the successful surgical treatment of these 4 patients and the impact of ectopic craniopharyngioma recurrence on survival.
  • [MeSH-major] Craniopharyngioma / secondary. Craniopharyngioma / surgery. Neoplasm Recurrence, Local / surgery. Pituitary Neoplasms / pathology. Pituitary Neoplasms / surgery

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  • (PMID = 19645541.001).
  • [ISSN] 1933-0707
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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69. Shuman AG, Heth JA, Marentette LJ, Blaivas M, Muraszko KM: Extracranial nasopharyngeal craniopharyngioma: case report. Neurosurgery; 2007 Apr;60(4):E780-1; discussion E781
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  • [Title] Extracranial nasopharyngeal craniopharyngioma: case report.
  • OBJECTIVE: Craniopharyngiomas (CPs) are benign tumors that almost always occur in a suprasellar location, making complete resection difficult and often necessitating radiotherapy.
  • Magnetic resonance imaging further revealed tumor invading the sphenoid body and the clivus and that the tumor had no intracranial extension.
  • CONCLUSION: CP with no intracranial extension is a very rare but benign tumor.
  • We recommend vigorous attempts to resect such tumors completely to minimize the chance of recurrence and the possible need for radiotherapy.
  • [MeSH-major] Craniopharyngioma / diagnosis. Craniopharyngioma / surgery. Nasopharyngeal Neoplasms / diagnosis. Nasopharyngeal Neoplasms / surgery. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / surgery

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  • (PMID = 17415187.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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70. Meuric S, Brauner R, Trivin C, Souberbielle JC, Zerah M, Sainte-Rose C: Influence of tumor location on the presentation and evolution of craniopharyngiomas. J Neurosurg; 2005 Nov;103(5 Suppl):421-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Influence of tumor location on the presentation and evolution of craniopharyngiomas.
  • OBJECT: This study was performed to optimize the management of craniopharyngiomas, particularly by identifying factors predicting weight changes to prevent obesity.
  • METHODS: A series of 35 patients who had undergone surgery at a mean age of 7.4 +/- 3.7 years (standard deviation [SD]) and had been followed up until 14.9 +/- 5 years of age by the same endocrinologist were assigned to one of three groups according to their hypothalamic involvement: Group 1 (10 patients) had no involvement, Group 2 (eight patients) had compression without involvement, and Group 3 (17 patients) had severe involvement.
  • Abnormal height and/or weight evolution indicated the craniopharyngioma in only 17% of the patients, although these elements were present at diagnosis in 85%.
  • All had complete hypothalamic-pituitary deficiencies after surgery.
  • CONCLUSIONS: The degree of hypothalamic involvement by the craniopharyngioma determines the presentation and predicts weight changes after surgery.
  • [MeSH-major] Craniopharyngioma / pathology. Craniopharyngioma / surgery. Hypothalamus / pathology. Pituitary Neoplasms / pathology. Pituitary Neoplasms / surgery
  • [MeSH-minor] Body Height. Body Mass Index. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Male. Neoplasm Invasiveness. Prognosis. Retrospective Studies. Weight Gain

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  • (PMID = 16302613.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. Caceres A, Reitman AJ, Tomita T: Craniopharyngioma and Cushing disease: case report. J Neurosurg; 2005 Apr;102(3 Suppl):318-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Craniopharyngioma and Cushing disease: case report.
  • Craniopharyngioma is a common sellar region tumor occurring in children.
  • Patients with craniopharyngioma commonly present with visual deficits and hydrocephalus.
  • The authors present the case of a child who presented with short stature and clinical evidence of Cushing disease (CD) associated with a suprasellar tumor.
  • The patient underwent insertion of an Ommaya reservoir into the tumor's cystic portion.
  • After adequate decompression of the tumor, the patient underwent total resection.
  • The tumor pathology was compatible with an adamantinomatous craniopharyngioma and immunohistochemical studies failed to show staining for ACTH.
  • [MeSH-major] Central Nervous System Cysts / surgery. Craniopharyngioma / surgery. Pituitary ACTH Hypersecretion / surgery. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adrenocorticotropic Hormone / blood. Adult. Child. Cyst Fluid / chemistry. Diagnosis, Differential. Dwarfism, Pituitary / etiology. Follow-Up Studies. Hemianopsia / etiology. Humans. Hypophysectomy. Hypopituitarism / etiology. Magnetic Resonance Imaging. Male. Obesity / etiology. Postoperative Complications / etiology. Tomography, X-Ray Computed

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  • (PMID = 15881759.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9002-60-2 / Adrenocorticotropic Hormone
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72. Pettorini BL, Inzitari R, Massimi L, Tamburrini G, Caldarelli M, Fanali C, Cabras T, Messana I, Castagnola M, Di Rocco C: The role of inflammation in the genesis of the cystic component of craniopharyngiomas. Childs Nerv Syst; 2010 Dec;26(12):1779-84
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  • [Title] The role of inflammation in the genesis of the cystic component of craniopharyngiomas.
  • BACKGROUND: Craniopharyngioma accounts for 5-10% of childhood tumors and, despite of the benign histological features, its clinical course can be malignant because of critical anatomical relationships with neural and vascular structures and the possible morbidity associated to resection.
  • METHODS: The acidic soluble proteins contained in the cystic fluid of six patients with cystic craniopharyngioma, three of them treated with intratumoral interferon-α, were analyzed.
  • INTERPRETATION: Detection of α-defensins 1-3 excludes that cyst fluid formation can derive from disruption of blood-brain barrier and suggests the involvement of innate immune response in pathology of craniopharyngioma cyst formation.
  • The reduction of α-defensins could derive both from direct antitumoral effect of interferon-α on squamous epithelial cells of craniopharyngioma cyst and from its immuno-modulatory effects on the recruitment of cells of innate immune systems.
  • Additional studies will be necessary to establish the role of these molecules in the pathogenesis of craniopharyngioma, and further investigations will be necessary to confirm the efficacy of the antitumoral activity of interferon-α.
  • [MeSH-major] Craniopharyngioma / immunology. Cysts / immunology. Inflammation / immunology. Pituitary Neoplasms / immunology

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  • (PMID = 20668862.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Immunologic Factors; 0 / Interferon-alpha; 0 / alpha-Defensins
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73. Zada G, Laws ER: Surgical management of craniopharyngiomas in the pediatric population. Horm Res Paediatr; 2010;74(1):62-6
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  • [Title] Surgical management of craniopharyngiomas in the pediatric population.
  • BACKGROUND: Craniopharyngiomas (CPs) are benign, locally aggressive neoplasms that comprise approximately 10% of pediatric brain tumors.
  • CONCLUSION: Consistent longitudinal management by an interdisciplinary team can alter the treatment course in patients with CPs from a debilitating, morbid or lethal condition to a chronic, survivable disease with functional adult livelihood.
  • [MeSH-major] Craniopharyngioma / surgery. Pituitary Neoplasms / surgery

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20453478.001).
  • [ISSN] 1663-2826
  • [Journal-full-title] Hormone research in pædiatrics
  • [ISO-abbreviation] Horm Res Paediatr
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
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74. Müller HL: Childhood craniopharyngioma: current controversies on management in diagnostics, treatment and follow-up. Expert Rev Neurother; 2010 Apr;10(4):515-24
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  • [Title] Childhood craniopharyngioma: current controversies on management in diagnostics, treatment and follow-up.
  • Craniopharyngiomas are embryogenic malformations of the sellar region of low histological malignancy, thought to be derived from Rathke's pouch epithelium.
  • However, quality of survival is substantially reduced in many survivors, owing to long-term sequelae, such as extreme obesity caused by hypothalamic tumor involvement, which occurs in up to 40% of all cases.
  • The treatment of craniopharyngioma remains controversial.
  • Radical surgical strategies are associated with poor outcome in craniopharyngioma with hypothalamic involvement.
  • [MeSH-major] Craniopharyngioma / diagnosis. Craniopharyngioma / therapy. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / therapy

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  • (PMID = 20367205.001).
  • [ISSN] 1744-8360
  • [Journal-full-title] Expert review of neurotherapeutics
  • [ISO-abbreviation] Expert Rev Neurother
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 56
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75. Müller HL, Gebhardt U, Schröder S, Pohl F, Kortmann RD, Faldum A, Zwiener I, Warmuth-Metz M, Pietsch T, Calaminus G, Kolb R, Wiegand C, Sörensen N, study committee of KRANIOPHARYNGEOM 2000/2007: Analyses of treatment variables for patients with childhood craniopharyngioma--results of the multicenter prospective trial KRANIOPHARYNGEOM 2000 after three years of follow-up. Horm Res Paediatr; 2010;73(3):175-80
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  • [Title] Analyses of treatment variables for patients with childhood craniopharyngioma--results of the multicenter prospective trial KRANIOPHARYNGEOM 2000 after three years of follow-up.
  • BACKGROUND: Controversies surround various treatment variables for patients with childhood craniopharyngioma such as growth hormone (GH) replacement, which some believe can exacerbate recurrence/progression.
  • We prospectively assessed the risk of tumor recurrence/progression in survivors of childhood craniopharyngioma.
  • METHODS: Multivariable analyses of risk factors (age at diagnosis, degree of resection, irradiation, GH treatment and gender) and descriptive analyses of overall survival (OS) and event-free survival (EFS) rates were performed in 117 patients, recruited prospectively and evaluated after 3 years of follow-up in the German, Austrian and Swiss multicenter trial KRANIOPHARYNGEOM 2000.
  • CONCLUSIONS: Tumor recurrences/progressions are frequent and occur early after initial treatment of childhood craniopharyngioma.
  • A radical resection preserving the integrity of hypothalamic structures appears optimal at original diagnosis.
  • However, further conclusions on the influence of GH on recurrence rates have to be refined to long-term follow-up studies of patients with childhood craniopharyngioma.
  • [MeSH-major] Craniopharyngioma / therapy. Pituitary Neoplasms / therapy
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Disease Progression. Disease-Free Survival. Female. Follow-Up Studies. Human Growth Hormone / therapeutic use. Humans. Infant. Male. Multivariate Analysis. Neoplasm Recurrence, Local / prevention & control. Prospective Studies. Risk Factors. Treatment Outcome

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20197669.001).
  • [ISSN] 1663-2826
  • [Journal-full-title] Hormone research in pædiatrics
  • [ISO-abbreviation] Horm Res Paediatr
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 12629-01-5 / Human Growth Hormone
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76. Lee YH, Kim SD, Lim DJ, Park JY, Chung YG, Kim YS: Isolated petroclival craniopharyngioma with aggressive skull base destruction. Yonsei Med J; 2009 Oct 31;50(5):729-31
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  • [Title] Isolated petroclival craniopharyngioma with aggressive skull base destruction.
  • We report a rare case of petroclival craniopharyngioma with no connection to the sellar or suprasellar region.
  • Here, we report the clinical features and radiographic investigation of this uncommon craniopharyngioma arising primarily in the petroclival region.
  • [MeSH-major] Cranial Fossa, Posterior / pathology. Craniopharyngioma / diagnosis. Pituitary Neoplasms / diagnosis. Skull Base Neoplasms / diagnosis

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  • (PMID = 19881982.001).
  • [ISSN] 1976-2437
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2768253
  • [Keywords] NOTNLM ; Craniopharyngioma / petroclival / skull base
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77. Schubert T, Trippel M, Tacke U, van Velthoven V, Gumpp V, Bartelt S, Ostertag C, Nikkhah G: Neurosurgical treatment strategies in childhood craniopharyngiomas: is less more? Childs Nerv Syst; 2009 Nov;25(11):1419-27
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  • [Title] Neurosurgical treatment strategies in childhood craniopharyngiomas: is less more?
  • OBJECTIVE: Craniopharyngiomas in children are typically present in combination with heterogeneous clinical and neuroradiological findings.
  • It has remained highly challenging to choose the optimal treatment strategy with regard to local tumor control and clinical outcome.
  • METHODS: We performed a detailed retrospective evaluation of 32 children <18 years old treated for craniopharyngioma between 1990 and 2008 at the University Hospital Freiburg.
  • Two of seven patients in this group have tumor recurrences.
  • Fourteen of the 17 children treated with microsurgical resection show tumor recurrences (p=0.02).
  • [MeSH-major] Brain Neoplasms / surgery. Craniopharyngioma / surgery. Neurosurgical Procedures / methods
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Cohort Studies. Cysts / radiotherapy. Cysts / surgery. Female. Follow-Up Studies. Humans. Infant. Male. Microsurgery / methods. Neoplasm Recurrence, Local. Radiotherapy / methods. Retrospective Studies. Stereotaxic Techniques. Treatment Outcome

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  • (PMID = 19714341.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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78. Kyrgiannis K, Mourgela S, Karamanakos PN, Liaropoulos K, Papadakis N: Optimal treatment of a recurrent giant craniopharyngioma: lessons from a case. J BUON; 2008 Oct-Dec;13(4):593-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Optimal treatment of a recurrent giant craniopharyngioma: lessons from a case.
  • A case of a 33-year-old man presented with symptoms of dramatic deterioration of the level of consciousness because of a recurrence of a previously aspirated and irradiated craniopharyngioma is described.
  • The tumor had grown enormously in dimensions and was extending in the region of hypothalamus, third ventricle and brain stem, with signs of local compression and obstructive hydrocephalus.
  • We conclude that in expert hands, microsurgery aiming at total removal should be the therapeutic option for the treatment of recurrent as well as primary craniopharyngiomas.
  • [MeSH-major] Craniopharyngioma / surgery. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male. Microsurgery. Neoplasm Recurrence, Local. Tomography, X-Ray Computed

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  • (PMID = 19145689.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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79. Gupta DK, Ojha BK, Sarkar C, Mahapatra AK, Mehta VS: Recurrence in craniopharyngiomas: analysis of clinical and histological features. J Clin Neurosci; 2006 May;13(4):438-42
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  • [Title] Recurrence in craniopharyngiomas: analysis of clinical and histological features.
  • The aim of this study was to investigate the recurrence patterns and significance of various clinical and histological features as predictors of recurrence in craniopharyngiomas.
  • A series of 234 craniopharyngiomas (156 males, 78 females; age range 1.6-65 years) was reviewed.
  • Peri-operative mortality was 7.4% and tumor recurrence was observed in 26 patients (20.3%).
  • Of the patients with recurrence, one had total tumor excision (recurrence-free survival (RFS) 14 months), four had near-total excision (mean RFS 18.2 months) and 21 had subtotal tumor excision (RFS for symptomatic recurrence 7.1 months).
  • Brain tissue was included in 67 cases and brain invasion was noted in 44 (all were of adamantinous histology).
  • No correlation was noted between histopathological subtyping or brain invasion and recurrence.
  • The significant clinical factors predictive of recurrence included the extent of resection, tumor size greater than 4 cm and cystic tumors.
  • [MeSH-major] Brain Neoplasms / pathology. Craniopharyngioma / pathology. Neoplasm Recurrence, Local / pathology

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  • (PMID = 16678722.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Scotland
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80. Müller HL: Childhood craniopharyngioma--current concepts in diagnosis, therapy and follow-up. Nat Rev Endocrinol; 2010 Nov;6(11):609-18
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  • [Title] Childhood craniopharyngioma--current concepts in diagnosis, therapy and follow-up.
  • Craniopharyngiomas have an overall incidence of 0.5-2.0 new cases per million of the population per year, and ∼30-50% of all cases represent childhood craniopharyngioma.
  • These partly cystic embryogenic malformations of the sellar region are presumably derived from Rathke cleft epithelium.
  • Many of the typical manifestations at primary diagnosis are nonspecific and include headache, visual impairment, polyuria and/or polydypsia, growth retardation and weight gain.
  • Total resection is the treatment of choice in patients with favorable tumor localization, with the intention to maintain hypothalamic-pituitary and optical nerve functions.
  • When the tumor localization is unfavorable, a limited resection followed by local irradiation is recommended.
  • Irradiation of the tumor is protective and the appropriate time point of irradiation after incomplete resection is currently under investigation in a randomized trial.
  • [MeSH-major] Craniopharyngioma / diagnosis. Craniopharyngioma / surgery. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / therapy
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Diagnosis, Differential. Growth Disorders. Headache. Humans. Infant. Magnetic Resonance Imaging. Neoplasm Recurrence, Local / epidemiology. Obesity / epidemiology. Obesity / surgery. Polyuria. Radiotherapy, Adjuvant. Tomography, X-Ray Computed. Vision Disorders

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  • (PMID = 20877295.001).
  • [ISSN] 1759-5037
  • [Journal-full-title] Nature reviews. Endocrinology
  • [ISO-abbreviation] Nat Rev Endocrinol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
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81. Burghaus S, Hölsken A, Buchfelder M, Fahlbusch R, Riederer BM, Hans V, Blümcke I, Buslei R: A tumor-specific cellular environment at the brain invasion border of adamantinomatous craniopharyngiomas. Virchows Arch; 2010 Mar;456(3):287-300
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  • [Title] A tumor-specific cellular environment at the brain invasion border of adamantinomatous craniopharyngiomas.
  • Craniopharyngiomas (CP) are benign epithelial tumors of the sellar region and can be clinicopathologically distinguished into adamantinomatous (adaCP) and papillary (papCP) variants.
  • Both subtypes are classified according to the World Health Organization grade I, but their irregular digitate brain infiltration makes any complete surgical resection difficult to obtain.
  • Herein, we characterized the cellular interface between the tumor and the surrounding brain tissue in 48 CP (41 adaCP and seven papCP) compared to non-neuroepithelial tumors, i.e., 12 cavernous hemangiomas, 10 meningiomas, and 14 metastases using antibodies directed against glial fibrillary acid protein (GFAP), vimentin, nestin, microtubule-associated protein 2 (MAP2) splice variants, and tenascin-C.
  • Furthermore, the outer tumor cell layer of adaCP showed a distinct expression of MAP2, a novel finding helpful in the differential diagnosis of epithelial tumors in the sellar region.
  • Our data support the hypothesis that adaCP, unlike other non-neuroepithelial tumors of the central nervous system, create a tumor-specific cellular environment at the tumor-brain junction.
  • Whether this facilitates the characteristic infiltrative growth pattern or is the consequence of an activated Wnt signaling pathway, detectable in 90% of these tumors, will need further consideration.
  • [MeSH-major] Craniopharyngioma / pathology. Pituitary Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Brain / metabolism. Child. Child, Preschool. Female. Gene Expression Regulation, Neoplastic. Glial Fibrillary Acidic Protein / metabolism. Humans. Intermediate Filament Proteins / metabolism. Male. Microtubule-Associated Proteins / metabolism. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Invasiveness / physiopathology. Neoplasm Metastasis / pathology. Neoplasm Metastasis / physiopathology. Nerve Tissue Proteins / metabolism. Nestin. Tenascin / metabolism. Vimentin / metabolism

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  • (PMID = 20069432.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein; 0 / Intermediate Filament Proteins; 0 / Microtubule-Associated Proteins; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin; 0 / Tenascin; 0 / Vimentin
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82. Zhou L, Luo L, Xu J, Li Q, Chen J, Jiang S, Cai B, You C: Craniopharyngiomas in the posterior fossa: a rare subgroup, diagnosis, management and outcomes. J Neurol Neurosurg Psychiatry; 2009 Oct;80(10):1150-4
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  • [Title] Craniopharyngiomas in the posterior fossa: a rare subgroup, diagnosis, management and outcomes.
  • OBJECTIVE: Craniopharyngiomas with predominant pars in the posterior fossa are very rare and extremely overlooked.
  • The clinical features, diagnosis and management are different from their sellar/suprasellar counterparts.
  • The purpose of this study was to explore the differing characteristics of posterior fossa craniopharyngiomas.
  • METHODS: Seven patients with pathologically proven craniopharyngiomas located in the posterior fossa were retrospectively investigated.
  • All tumours were located in the retrochiasmatic area, and five of seven displayed a retroinfundibulum growth pattern.
  • The predominant components of the tumours were located in the unilateral cerebellopontine angle (CPA) in six cases, and the bilateral CPA in one case.
  • Total tumour resection was accomplished in five patients.
  • Six patients fully recovered to normal conditions, but one patient had tumour regrowth and had to undergo a secondary resection.
  • CONCLUSIONS: Posterior fossa craniopharyngiomas are rare and may be considered an independent subgroup of classifications.
  • Tumours arising from the sellar region and extending to the posterior fossa present with their own unusual set of characteristics.
  • These tumours can be radically and safely removed with a combined supra- and intratentorial approach.
  • [MeSH-major] Craniopharyngioma / diagnosis. Craniopharyngioma / surgery. Infratentorial Neoplasms / diagnosis. Infratentorial Neoplasms / surgery. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / surgery

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  • [RetractionIn] J Neurol Neurosurg Psychiatry. 2010 Aug;81(8):942 [20682723.001]
  • (PMID = 19762904.001).
  • [ISSN] 1468-330X
  • [Journal-full-title] Journal of neurology, neurosurgery, and psychiatry
  • [ISO-abbreviation] J. Neurol. Neurosurg. Psychiatry
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Retracted Publication
  • [Publication-country] England
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83. Cannavò S, Marini F, Trimarchi F: Patients with craniopharyngiomas: therapeutical difficulties with growth hormone. J Endocrinol Invest; 2008 Sep;31(9 Suppl):56-60
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  • [Title] Patients with craniopharyngiomas: therapeutical difficulties with growth hormone.
  • Craniopharyngioma (CP) is a rare and benign tumor of the pituitary region.
  • Multiple pituitary deficiencies or panhypopituitarism and diabetes insipidus are very frequent and their prevalence increases significantly after neurosurgery.
  • In patients with GH deficiency (GHD), recombinant GH (rGH) replacement is recommended, after a near complete surgical excision of CP and exclusion of tumor progression.
  • [MeSH-major] Craniopharyngioma / drug therapy. Human Growth Hormone / adverse effects. Human Growth Hormone / therapeutic use. Pituitary Neoplasms / drug therapy

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  • (PMID = 19020388.001).
  • [ISSN] 0391-4097
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 12629-01-5 / Human Growth Hormone
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84. Gardner PA, Kassam AB, Snyderman CH, Carrau RL, Mintz AH, Grahovac S, Stefko S: Outcomes following endoscopic, expanded endonasal resection of suprasellar craniopharyngiomas: a case series. J Neurosurg; 2008 Jul;109(1):6-16
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  • [Title] Outcomes following endoscopic, expanded endonasal resection of suprasellar craniopharyngiomas: a case series.
  • OBJECT: Craniopharyngiomas are challenging tumors that most frequently occur in the sellar or suprasellar regions.
  • METHODS: The authors performed a retrospective review of all patients who underwent a purely endoscopic, expanded endonasal approach (EEA) for the resection of craniopharyngiomas at their institution between June 1999 and February 2006.
  • RESULTS: Sixteen patients underwent endoscopic EEA for the resection of craniopharyngiomas.
  • Five patients (31%) presented with recurrent disease.
  • Three elderly patients with vision loss underwent planned debulking, 1 patient with vision loss and a moderate-sized tumor had express wishes for debulking, and 1 patient had a separate, third ventricular nodule that was not resected.
  • No patient who underwent gross-total resection suffered a recurrence.
  • Of the 14 patients who presented with vision loss, 93% had improvement or complete recovery and 1 patient's condition remained stable.
  • CONCLUSIONS: Endoscopic EEA for the resection of craniopharyngiomas provides acceptable results and holds the potential to improve outcomes.
  • [MeSH-major] Craniopharyngioma / pathology. Craniopharyngioma / surgery. Endoscopy. Pituitary Neoplasms / pathology. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cohort Studies. Female. Humans. Male. Middle Aged. Nasal Cavity. Neoplasm Invasiveness. Retrospective Studies. Treatment Outcome

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  • [CommentIn] J Neurosurg. 2008 Jul;109(1):1; reply 3-5 [18590425.001]
  • [CommentIn] J Neurosurg. 2008 Jul;109(1):1-3; reply 3-5 [18590426.001]
  • (PMID = 18590427.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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85. Hölsken A, Kreutzer J, Hofmann BM, Hans V, Oppel F, Buchfelder M, Fahlbusch R, Blümcke I, Buslei R: Target gene activation of the Wnt signaling pathway in nuclear beta-catenin accumulating cells of adamantinomatous craniopharyngiomas. Brain Pathol; 2009 Jul;19(3):357-64

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  • [Title] Target gene activation of the Wnt signaling pathway in nuclear beta-catenin accumulating cells of adamantinomatous craniopharyngiomas.
  • Activating beta-catenin (CTNNB1) mutations can be identified in the majority of adamantinomatous craniopharyngiomas (adaCP), suggesting an aberrant Wnt signaling pathway in this histopathologically peculiar tumor entity.
  • We performed a laser-microdissection-based study comparing beta-catenin accumulating vs. non-accumulating tumor cells.
  • Mutational analysis and gene expression profiling using real-time polymerase chain reaction were conducted in adamantinomatous and papillary tumor specimens.
  • Target gene activation, that is, over-expression of Axin2 could be detected in adaCP, especially in tumor cells with nuclear beta-catenin accumulation.
  • Interestingly, accumulating and non-accumulating tumor cell populations carried CTNNB1 mutations within exon 3.
  • [MeSH-major] Craniopharyngioma / genetics. Signal Transduction / physiology. Transcriptional Activation. Wnt Proteins / metabolism. beta Catenin / metabolism
  • [MeSH-minor] Adolescent. Adult. Axin Protein. Bone Morphogenetic Protein 4 / genetics. Cell Nucleus / metabolism. Cell Nucleus / pathology. Child. Child, Preschool. Cytoskeletal Proteins / genetics. DNA Mutational Analysis. Female. Gene Expression. Humans. Immunohistochemistry. Male. Microdissection. Pituitary Neoplasms / genetics. Pituitary Neoplasms / metabolism. Pituitary Neoplasms / pathology. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 18540944.001).
  • [ISSN] 1750-3639
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / AXIN2 protein, human; 0 / Axin Protein; 0 / Bone Morphogenetic Protein 4; 0 / Cytoskeletal Proteins; 0 / Wnt Proteins; 0 / beta Catenin
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86. Kassam AB, Gardner PA, Snyderman CH, Carrau RL, Mintz AH, Prevedello DM: Expanded endonasal approach, a fully endoscopic transnasal approach for the resection of midline suprasellar craniopharyngiomas: a new classification based on the infundibulum. J Neurosurg; 2008 Apr;108(4):715-28
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  • [Title] Expanded endonasal approach, a fully endoscopic transnasal approach for the resection of midline suprasellar craniopharyngiomas: a new classification based on the infundibulum.
  • OBJECT: Craniopharyngiomas are notoriously difficult to treat.
  • Because of their parasellar location, often extending well beyond the sella, these tumors challenge vision and pituitary and hypothalamic function.
  • New techniques are needed to improve outcomes in patients with these tumors while decreasing treatment morbidity.
  • The authors explain the techniques and approach used for the endoscopic endonasal resection of suprasellar craniopharyngiomas and introduce a tumor classification scheme.
  • METHODS: The techniques and approach used for the endoscopic, endonasal resection of suprasellar craniopharyngiomas is explained, including the introduction of a tumor classification scheme.
  • RESULTS: The classification scheme divides tumors according to their suprasellar extension: Type I is preinfundibular; Type II is transinfundibular (extending into the stalk); Type III is retroinfundibular, extending behind the gland and stalk, and has 2 subdivisions (IIIa, extending into the third ventricle; and IIIb, extending into the interpeduncular cistern); and Type IV is isolated to the third ventricle and/or optic recess and is not accessible via an endonasal approach.
  • Moreover, in its application for craniopharyngiomas, an understanding of tumor growth and extension with respect to the optic chiasm and infundibulum is critical to safely approach the lesion via an endonasal route.
  • [MeSH-major] Craniopharyngioma / classification. Craniopharyngioma / surgery. Neuroendoscopy / methods. Pituitary Gland, Posterior / pathology. Pituitary Neoplasms / classification. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Nasal Cavity / surgery. Neoplasm Recurrence, Local / prevention & control

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  • [CommentIn] J Neurosurg. 2009 Jul;111(1):197-9; author reply 199 [19569961.001]
  • [CommentIn] J Neurosurg. 2008 Dec;109(6):1180-2; author reply 1182-3 [19035739.001]
  • (PMID = 18377251.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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87. Müller HL, Gebhardt U, Wessel V, Schröder S, Kolb R, Sörensen N, Maroske J, Hanisch E: First experiences with laparoscopic adjustable gastric banding (LAGB) in the treatment of patients with childhood craniopharyngioma and morbid obesity. Klin Padiatr; 2007 Nov-Dec;219(6):323-5
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  • [Title] First experiences with laparoscopic adjustable gastric banding (LAGB) in the treatment of patients with childhood craniopharyngioma and morbid obesity.
  • Craniopharyngiomas are embryogenic malformations which lead to eating disorders and morbid obesity due to hypothalamic involvement in about 50% of all patients with pediatric craniopharyngioma.
  • The experience with laparoscopic adjustable gastric banding (LAGB) in obese craniopharyngioma patients is limited.
  • We are reporting on four patients with childhood craniopharyngioma diagnosed at age 2, 11, 12, and 21 years.
  • BMI-SDS at diagnosis was +0.9, +4.5, +4.7 and -0.1 SD.
  • During follow-up, all patients developed morbid obesity (BMI-SDS: +13.9, +10.3, +11.4, +7.3) so that 11, 6, 9 and 3 years after diagnosis LAGB were performed.
  • We conclude that LAGB could be effective in weight reduction of obese craniopharyngioma patients with hypothalamic syndrome.
  • Close follow-up is necessary in order to analyze long-term effects and complications of LAGB in patients with childhood craniopharyngioma and morbid obesity.
  • [MeSH-major] Craniopharyngioma / complications. Gastroplasty. Laparoscopy. Obesity, Morbid / etiology. Obesity, Morbid / surgery. Pituitary Neoplasms / complications

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  • (PMID = 18050042.001).
  • [ISSN] 0300-8630
  • [Journal-full-title] Klinische Pädiatrie
  • [ISO-abbreviation] Klin Padiatr
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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88. Julow J, Backlund EO, Lányi F, Hajda M, Bálint K, Nyáry I, Szeifert GT: Long-term results and late complications after intracavitary yttrium-90 colloid irradiation of recurrent cystic craniopharyngiomas. Neurosurgery; 2007 Aug;61(2):288-95; discussion 295-6
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  • [Title] Long-term results and late complications after intracavitary yttrium-90 colloid irradiation of recurrent cystic craniopharyngiomas.
  • OBJECTIVE: Data were analyzed to assess the value of stereotactically applied intracystic colloidal yttrium-90 (YTx) for the treatment of recurrent cystic craniopharyngiomas during a 30-year period.
  • The treatment of retrosellar (retrochiasmatic, suprasellar) tumors occasionally induced hypothalamic and/or pontomesencephalothalamic damage obviously by untoward radiation to the so-called perforating arteries.
  • CONCLUSION: Despite sporadic complications, intracavitary YTx irradiation is a valuable treatment alternative for craniopharyngioma cysts, sometimes as part of a multimodality management in these tumors, especially in precarious surgical cases.
  • [MeSH-major] Brachytherapy / methods. Craniopharyngioma / radiotherapy. Cysts / radiotherapy. Pituitary Neoplasms / radiotherapy. Yttrium Radioisotopes / administration & dosage

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  • (PMID = 17762741.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Colloids; 0 / Yttrium Radioisotopes
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89. Pedreira CC, Stargatt R, Maroulis H, Rosenfeld J, Maixner W, Warne GL, Zacharin MR: Health related quality of life and psychological outcome in patients treated for craniopharyngioma in childhood. J Pediatr Endocrinol Metab; 2006 Jan;19(1):15-24
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  • [Title] Health related quality of life and psychological outcome in patients treated for craniopharyngioma in childhood.
  • Patients with craniopharyngioma are at risk for many adverse effects related to the tumour's invasive behaviour and its proximity to many vital structures.
  • Profound psychosocial problems, memory impairment, pituitary and hypothalamic dysfunction in addition to the physical handicap of visual loss are frequently recognized sequelae of craniopharyngioma treatment.
  • OBJECTIVES: To examine health related quality of life (QoL) and psychological outcomes of patients treated for craniopharyngioma at the Royal Children's Hospital, Melbourne, between January 1980 and September 2003.
  • Eighteen of 30 (8 male), mean age 21.2 +/- 6.7 years, agreed to evaluation, of whom 16/18 (88.9%) had three or more pituitary hormone deficiencies, 11/18 had visual impairment and 9/18 obesity.
  • The General Health score of patients was significantly worse than for controls on PGWB (p = 0.025), anxiety was higher in those who had surgery alone (p = 0.008) and subjective QoL associated with GHD using AGHDA was lower (p = 0.006).
  • Few craniopharyngioma survivors (18/30) were available for evaluation, demonstrating difficulties in attempts to assess this complex group.
  • CONCLUSIONS: Craniopharyngioma and its treatment result in significant, complex medical, social, psychological and emotional difficulties.
  • [MeSH-major] Craniopharyngioma / psychology. Hypothalamus / physiopathology. Pituitary Neoplasms / psychology. Quality of Life / psychology

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  • [CommentIn] J Pediatr Endocrinol Metab. 2006 Jan;19(1):11-3 [16509523.001]
  • (PMID = 16509524.001).
  • [ISSN] 0334-018X
  • [Journal-full-title] Journal of pediatric endocrinology & metabolism : JPEM
  • [ISO-abbreviation] J. Pediatr. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] England
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90. Hirunpat S, Tanomkiat W, Sriprung H, Chetpaophan J: Optic tract edema: a highly specific magnetic resonance imaging finding for the diagnosis of craniopharyngiomas. Acta Radiol; 2005 Jul;46(4):419-23
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  • [Title] Optic tract edema: a highly specific magnetic resonance imaging finding for the diagnosis of craniopharyngiomas.
  • PURPOSE: To clarify the accuracy, sensitivity, and specificity of optic tract edema in the diagnosis of craniopharyngiomas.
  • MATERIAL AND METHODS: Preoperative magnetic resonance images (MRIs) of 49 patients (between May 1996 and March 2003) who had a diagnosis of parasellar masses were blindly reviewed by two radiologists.
  • The spread of edema surrounding the tumor on the coronal TSE T2-weighted images was analyzed.
  • RESULTS: Edema along the optic tracts was detected in 7 of 11 craniopharyngiomas, giving a sensitivity of 63.6% (95% CI = 30.8-89.1) for our series and 66.7% (95% CI = 47.2-82.7) for the pooled numbers.
  • None of the 28 pituitary macroadenomas, 4 meningiomas, 2 hypothalamic astrocytomas, 2 germinomas, 1 mixed-germ cell tumor and 1 arachnoid cyst in our study showed edema of the optic pathways.
  • CONCLUSION: Optic tract edema, commonly seen in craniopharyngiomas, is a useful MR finding for distinguishing craniopharyngiomas from other parasellar tumors with considerable sensitivity and high specificity.
  • [MeSH-major] Craniopharyngioma / diagnosis. Edema / diagnosis. Magnetic Resonance Imaging / methods. Pituitary Neoplasms / diagnosis. Visual Pathways / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Male. Middle Aged. Observer Variation. Predictive Value of Tests. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 16134321.001).
  • [ISSN] 0284-1851
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
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91. Kusama K, Katayama Y, Oba K, Ishige T, Kebusa Y, Okazawa J, Fukushima T, Yoshino A: Expression of hard alpha-keratins in pilomatrixoma, craniopharyngioma, and calcifying odontogenic cyst. Am J Clin Pathol; 2005 Mar;123(3):376-81
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  • [Title] Expression of hard alpha-keratins in pilomatrixoma, craniopharyngioma, and calcifying odontogenic cyst.
  • To examine the properties of shadow and ghost cells, 3 kinds of antibodies were raised against human hair proteins and their immunoreactivity was examined in tumors expressing those cells: pilomatrixoma, 14 cases; craniopharyngioma, 17 cases; and calcifying odontogenic cyst (COC), 14 cases.
  • Positive reactions were found only in shadow cells of all 13 adamantinomatous craniopharyngiomas.
  • The appearance of shadow or ghost cells might represent differentiation into hair in these 3 kinds of tumors.
  • [MeSH-major] Craniopharyngioma / metabolism. Hair Diseases / metabolism. Keratins / metabolism. Neoplasm Proteins / metabolism. Neoplasms / metabolism. Odontogenic Cyst, Calcifying / metabolism. Pilomatrixoma / metabolism
  • [MeSH-minor] Animals. Biomarkers, Tumor / immunology. Biomarkers, Tumor / metabolism. Blotting, Western. Cells, Cultured. Hair / chemistry. Humans. Hybridomas. Immunoenzyme Techniques. Jaw Neoplasms / metabolism. Jaw Neoplasms / pathology. Mice. Mice, Inbred BALB C. Pituitary Neoplasms / metabolism. Pituitary Neoplasms / pathology. Skin Neoplasms / metabolism. Skin Neoplasms / pathology

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  • (PMID = 15716233.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 68238-35-7 / Keratins
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92. Metzler-Baddeley C, Jones RW: Brief communication: cognitive rehabilitation of executive functioning in a case of craniopharyngioma. Appl Neuropsychol; 2010 Oct;17(4):299-304
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  • [Title] Brief communication: cognitive rehabilitation of executive functioning in a case of craniopharyngioma.
  • Craniopharyngiomas are rare brain tumors within the area of the craniopharyngeal duct.
  • This single-case report describes a brief investigation into the effectiveness of goal management training for dysexecutive problems following the removal and treatment of a craniopharyngioma in a young woman.
  • Thus, the exploitation of naturally occurring external distractions as periodic alerts to facilitate goal management can be an effective and easy-to-adopt cognitive rehabilitation strategy for dysexecutive problems associated with craniopharyngioma.
  • [MeSH-major] Cognition Disorders / rehabilitation. Cognitive Therapy / methods. Craniopharyngioma / complications. Craniopharyngioma / rehabilitation. Executive Function / physiology

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  • (PMID = 21154044.001).
  • [ISSN] 1532-4826
  • [Journal-full-title] Applied neuropsychology
  • [ISO-abbreviation] Appl Neuropsychol
  • [Language] eng
  • [Publication-type] Case Reports; Clinical Conference; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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93. Tena-Suck ML, Ortiz-Plata A, Galán F, Sánchez A: Expression of epithelial cell adhesion molecule and pituitary tumor transforming gene in adamantinomatous craniopharyngioma and its correlation with recurrence of the tumor. Ann Diagn Pathol; 2009 Apr;13(2):82-8
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  • [Title] Expression of epithelial cell adhesion molecule and pituitary tumor transforming gene in adamantinomatous craniopharyngioma and its correlation with recurrence of the tumor.
  • Craniopharyngiomas are benign tumors of the sellar region generally associated with endocrine disorders and often locally aggressive.
  • The reliable criteria for predicting the tumor behavior are still lacking.
  • It has been suggested that proliferative potential of the tumor cells is necessary for recurrence.
  • The aim of this study was to evaluate the activity and correlation of epithelial cell adhesion molecule (Ep-CAM) and pituitary tumor transforming gene (PTTG-1) immunoexpression that is possibly related to relapse in 40 patients with adamantinomatous craniopharyngioma.
  • Both were higher in recurrence/regrowth tumors than in primary one.
  • The PTGG-1 expression in craniopharyngioma may suggest hypophyseal metaplasia.
  • The Ep-CAM and PTTG-1 expression in craniopharyngioma could be used as prediction markers of relapsing tumor.
  • It has been suggested that proliferative potential of the tumor cells is necessary for recurrence.
  • [MeSH-major] Antigens, Neoplasm / biosynthesis. Cell Adhesion Molecules / biosynthesis. Craniopharyngioma / metabolism. Neoplasm Proteins / biosynthesis. Neoplasm Recurrence, Local / metabolism. Pituitary Neoplasms / metabolism
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Female. Gene Expression. Humans. Immunohistochemistry. Male. Securin

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  • [CommentIn] Ann Diagn Pathol. 2009 Dec;13(6):428-9 [19917481.001]
  • (PMID = 19302955.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Cell Adhesion Molecules; 0 / EPCAM protein, human; 0 / Neoplasm Proteins; 0 / Securin; 0 / pituitary tumor-transforming protein 1, human
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94. Tsutsumi S, Yasumoto Y, Ito M: Central pontine and extrapontine myelinolysis in an infant associated with the treatment of craniopharyngioma: case report. Neurol Med Chir (Tokyo); 2008 Aug;48(8):351-4
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  • [Title] Central pontine and extrapontine myelinolysis in an infant associated with the treatment of craniopharyngioma: case report.
  • A 3-year-old girl presented with osmotic demyelination syndrome after undergoing uneventful neuroendoscopic cystostomy for a growing cystic suprasellar craniopharyngioma following microscopic subtotal resection 1 year previously.
  • Suprasellar craniopharyngioma with long-standing hypothalamic dysfunction may be associated with severe osmotic demyelination syndrome even after less invasive surgery, so serum sodium derangement after surgery should be promptly corrected even if only subtle signs are present.
  • [MeSH-major] Craniopharyngioma / surgery. Hyponatremia / complications. Myelinolysis, Central Pontine / etiology. Neurosurgical Procedures / adverse effects. Postoperative Complications / etiology. Water-Electrolyte Balance / physiology
  • [MeSH-minor] Brain / pathology. Brain / physiopathology. Child, Preschool. Consciousness Disorders / etiology. Consciousness Disorders / pathology. Consciousness Disorders / physiopathology. Disease Progression. Female. Fever / complications. Fever / etiology. Hormone Replacement Therapy. Humans. Hypothalamus / injuries. Hypothalamus / pathology. Hypothalamus / physiopathology. Magnetic Resonance Imaging. Nerve Fibers, Myelinated / pathology. Pons / pathology. Pons / physiopathology. Vasopressins / agonists


95. Karavitaki N, Scheithauer BW, Watt J, Ansorge O, Moschopoulos M, Llaguno AV, Wass JA: Collision lesions of the sella: co-existence of craniopharyngioma with gonadotroph adenoma and of Rathke's cleft cyst with corticotroph adenoma. Pituitary; 2008;11(3):317-23
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  • [Title] Collision lesions of the sella: co-existence of craniopharyngioma with gonadotroph adenoma and of Rathke's cleft cyst with corticotroph adenoma.
  • Most contributions include a pituitary adenoma or a cyst/cystic tumor, particularly a Rathke cleft cyst.
  • The association of craniopharyngioma with an adenoma is particularly rare.
  • Among reported cases, some have included secondary prolactin cell hyperplasia due to pituitary stalk section effect.
  • Herein, we report two collision lesions, including a gonadotroph adenoma with adamantinomatous craniopharyngioma and a corticotroph adenoma with Rathke's cleft cyst.
  • [MeSH-major] ACTH-Secreting Pituitary Adenoma / complications. Adenoma / complications. Central Nervous System Cysts / complications. Corticotrophs / pathology. Craniopharyngioma / complications. Gonadotrophs / pathology. Pituitary Neoplasms / complications. Sella Turcica / pathology

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  • (PMID = 17917812.001).
  • [ISSN] 1386-341X
  • [Journal-full-title] Pituitary
  • [ISO-abbreviation] Pituitary
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 65
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96. Qiu SJ, Guo YL, Zhang XL, Zhang F, Zhang YZ, Wen G, Hu BS: [Imaging findings of craniopharyngioma in relation to its surgical management: a retrospective analysis]. Nan Fang Yi Ke Da Xue Xue Bao; 2007 Jul;27(7):980-2
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  • [Title] [Imaging findings of craniopharyngioma in relation to its surgical management: a retrospective analysis].
  • OBJECTIVE: To analyze the CT and magnetic resonance imaging (MRI) findings of craniopharygioma and explore the correlation between the pathological findings and clinical features of the disease.
  • Of the 123 craniopharyngioma patients, 59 were found to have adamantinous craniopharyngiomas, 41 had papillary squamous craniopharyngiomas, and 23 had mixed tumors.
  • Solid tumor was found in 18 cases, cystic tumor in 38 cases, and calcification in 78 cases; in 23 cases, the posterior of the tumor did not exhibit clear boundary from the wall of the three cerebral ventricles, and in 11 cases CT and MRI displayed hypophysial stalk, which was found intraoperatively in 53 cases.
  • CONCLUSIONS: MRI allows clear vision of the range of craniopharyngioma involvement and the anatomical structures surrounding the tumor.
  • Accurate identification of the site, dimension, calcification patterns and relation between the hypophysial stalk and hypothalamus by the imaging modalities significantly benefits the optimization of the surgical plan for the tumor.
  • [MeSH-major] Craniopharyngioma / diagnosis. Craniopharyngioma / surgery. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 17666331.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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97. Kalapurakal JA: Radiation therapy in the management of pediatric craniopharyngiomas--a review. Childs Nerv Syst; 2005 Aug;21(8-9):808-16
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  • [Title] Radiation therapy in the management of pediatric craniopharyngiomas--a review.
  • Craniopharyngiomas are benign suprasellar tumors that arise from epithelial remnants of the Rathke's pouch.
  • Optic neuropathy and brain necrosis are rare in modern radiation therapy series.
  • In children with recurrent craniopharyngiomas following radical surgery, the recommended salvage treatment is radiation therapy, as further surgical attempts at salvage are associated with high relapse rates and increased morbidity and mortality.
  • There have been significant technological advances in the field of radiation treatment planning and delivery that have great potential for reducing the incidence of long-term irradiation sequelae in the developing brain.
  • The general availability of megavoltage linear accelerators and modern radiotherapy innovations such as three-dimensional conformal radiation treatment (3D CRT), stereotactic radiosurgery (SRS), stereotactic radiotherapy (SRT), and intensity modulated radiation therapy (IMRT) should further limit the rate of complications and improve cure rates in children with primary or recurrent craniopharyngioma.
  • [MeSH-major] Craniopharyngioma / radiotherapy. Pituitary Neoplasms / radiotherapy. Radiosurgery / methods

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  • (PMID = 16075214.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 66
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98. Pierre-Kahn A, Recassens C, Pinto G, Thalassinos C, Chokron S, Soubervielle JC, Brauner R, Zerah M, Sainte Rose C: Social and psycho-intellectual outcome following radical removal of craniopharyngiomas in childhood. A prospective series. Childs Nerv Syst; 2005 Aug;21(8-9):817-24
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  • [Title] Social and psycho-intellectual outcome following radical removal of craniopharyngiomas in childhood. A prospective series.
  • BACKGROUND: A prospective study on childhood craniopharyngiomas (CPs) was conducted from 1994 to 1998 to appreciate the pre- and postoperative clinical, endocrine, mental, and intellectual status of the patients and to determine the incidence and severity of the postoperative hypothalamic syndrome.
  • CONCLUSION: At 2-year follow-up, the two children with an extraventricular CP and a "total" tumor removal were intellectually normal, had no hypothalamic syndrome, and attended normal school with good results.
  • [MeSH-major] Craniopharyngioma / surgery. Intelligence / physiology. Pituitary Neoplasms / surgery. Postoperative Period. Social Behavior

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  • (PMID = 16049724.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Germany
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99. Pereira AM, Schmid EM, Schutte PJ, Voormolen JH, Biermasz NR, van Thiel SW, Corssmit EP, Smit JW, Roelfsema F, Romijn JA: High prevalence of long-term cardiovascular, neurological and psychosocial morbidity after treatment for craniopharyngioma. Clin Endocrinol (Oxf); 2005 Feb;62(2):197-204
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  • [Title] High prevalence of long-term cardiovascular, neurological and psychosocial morbidity after treatment for craniopharyngioma.
  • INTRODUCTION: The treatment of craniopharyngiomas is associated with long-term morbidity.
  • AIM OF THE STUDY: To assess the long-term functional outcome and mortality rates after treatment for craniopharyngiomas, we audited our data with special focus on cardiovascular, neurological and psychosocial morbidity.
  • PATIENTS AND METHODS: Between 1965 and 2002, 54 consecutive patients underwent surgery for craniopharyngiomas at the Leiden University Medical Centre (LUMC).
  • CONCLUSION: Craniopharyngioma is associated with excessive long-term multisystem morbidity and mortality, especially in female patients, despite a high cure rate.
  • The purpose of the follow-up should be: first, to look for recurrences and to ensure appropriate endocrine replacement, especially oestrogen replacement in premenopausal females; and second, to achieve intensive control of glucose, lipids, blood pressure and weight, as in any other patient with increased risk for cardiovascular disease.
  • [MeSH-major] Craniopharyngioma / therapy. Pituitary Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Cardiovascular Diseases / etiology. Child. Child, Preschool. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Morbidity. Neoplasm Recurrence, Local. Nervous System Diseases / etiology. Prevalence. Risk. Sex Factors. Survival Rate. Time Factors. Visual Acuity. Visual Fields

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  • (PMID = 15670196.001).
  • [ISSN] 0300-0664
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 30
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100. Moschovi M, Alexiou GA, Dastamani A, Stefanaki K, Prodromou N, Hatzigiorgi H, Karamolegou K, Tzortzatou-Stathopoulou F: Alpha-fetoprotein secretion in a craniopharyngioma. Are craniopharyngiomas part of the germ cell tumor family? Acta Neurol Belg; 2010 Sep;110(3):272-5
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  • [Title] Alpha-fetoprotein secretion in a craniopharyngioma. Are craniopharyngiomas part of the germ cell tumor family?
  • Brain CT and MRI revealed a suprasellar cystic and partially solid mass with calcifications.
  • These findings were suggestive for a brain germ cell tumor.
  • After two courses there was a reduction in the levels of AFP but the tumor size remained unchanged.
  • Subtotal tumor excision was performed that revealed the presence of a craniopharyngioma.
  • One month later there was enlargement of the cystic part of the tumor, while serum AFP was elevated.
  • The child received again systemic chemotherapy and placement of a reservoir into the cystic part of the tumor.
  • These observations support the theory of a germ cell tumor family, in which craniopharyngioma and germ cell tumor present the two sides of the same entity, while between them a wide variety of tumors, with variable type of secretion of AFP and/or beta-HCG, may exist.
  • [MeSH-major] Craniopharyngioma. Neoplasms, Germ Cell and Embryonal / classification. Pituitary Neoplasms. alpha-Fetoproteins / secretion

  • Genetic Alliance. consumer health - Craniopharyngioma.
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  • (PMID = 21114138.001).
  • [ISSN] 0300-9009
  • [Journal-full-title] Acta neurologica Belgica
  • [ISO-abbreviation] Acta Neurol Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / AFP protein, human; 0 / alpha-Fetoproteins
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