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6. Kamath KP, Vidya M, Shetty N, Karkera BV, Jogi H: Nucleolar organizing regions and alpha-smooth muscle actin expression in a case of ameloblastic carcinoma. Head Neck Pathol; 2010 Jun;4(2):157-62
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  • It is defined as a malignant epithelial odontogenic tumor that histologically has retained the features of ameloblastic differentiation and also exhibits cytologic features of malignancy, like atypia and mitotic activity.
  • Although this lesion represents a separate entity, differentiating it from ameloblastoma has been often challenging to pathologists.
  • In this case study reporting a case of ameloblastic carcinoma, we have attempted to verify the previous findings on the use of Argyrophilic nucleolar organizing regions (AgNORs) and immunohistochemical staining for the alpha-smooth muscle actin (alpha-SMA) in differentiating ameloblastic carcinoma from ameloblastoma.
  • It was observed that AgNORs was found to be almost twice in ameloblastic carcinoma as it was in ameloblastoma.
  • A difference between the two lesions in the pattern of expression of alpha-SMA was also observed, with alpha-SMA being expressed in the odontogenic epithelium and the stroma of ameloblastic carcinoma whereas, in the case of ameloblastoma, it was found only in the stromal part.
  • These findings suggest that AgNORs and alpha-SMA expression may be used as adjuncts to the routine histopathologic examination to differentiate ameloblastic carcinoma and ameloblastoma.
  • [MeSH-major] Actins / metabolism. Ameloblastoma / pathology. Carcinoma / pathology. Mandibular Neoplasms / pathology. Nucleolus Organizer Region / pathology
  • [MeSH-minor] Antigens, Nuclear / analysis. Antigens, Nuclear / genetics. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Mandible / pathology. Mandible / surgery. Middle Aged

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  • (PMID = 20333560.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ACTA2 protein, human; 0 / Actins; 0 / Antigens, Nuclear; 0 / Biomarkers, Tumor; 0 / nucleolar organizer region associated proteins
  • [Other-IDs] NLM/ PMC2878627
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7. Kitsoulis P, Charchanti A, Paraskevas G, Marini A, Karatzias G: Adamantinoma. Acta Orthop Belg; 2007 Aug;73(4):425-31
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  • [Title] Adamantinoma.
  • Adamantinoma is one of the rarest low-grade malignant bone tumours, representing less than 1% of them.
  • Fisher in 1913 named this tumour adamantinoma because of its similarity to ameloblastoma of the jaw.
  • Young males are more prone to develop adamantinoma than females.
  • [MeSH-major] Adamantinoma. Bone Neoplasms

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  • (PMID = 17939469.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 58
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8. Hatori M, Watanabe M, Hosaka M, Sasano H, Narita M, Kokubun S: A classic adamantinoma arising from osteofibrous dysplasia-like adamantinoma in the lower leg: a case report and review of the literature. Tohoku J Exp Med; 2006 May;209(1):53-9
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  • [Title] A classic adamantinoma arising from osteofibrous dysplasia-like adamantinoma in the lower leg: a case report and review of the literature.
  • Adamantinoma is known as a low-grade malignant biphasic tumor.
  • Classic adamantinoma is in general characterized by admixture of both epithelial and osteofibrous components that are associated with various proportions and differentiation patterns.
  • OFD-like adamantinoma is characterized by predominance of osteofibrous tissues, in which small groups of epithelial cells are only detected by careful search or immunohistochemistry.
  • There have been controversies as to the potential correlation among OFD, OFD-like adamantinoma and classic adamantinoma.
  • We report an unusual case of adamantinoma arising in the tibia, with an extensive review of the literature.
  • The present findings suggest a direct correlation between OFD-like adamantinoma and classic adamantinoma.
  • The biopsy lesion was diagnosed as classic adamantinoma.
  • The primary lesion was retrospectively diagnosed as OFD-like adamantinoma because of presence of keratin-positive epithelial cells within the stroma.
  • The retrospective histological findings of OFD-like adamantinoma in the original biopsy and of a classic adamantinoma in all sections of the later resection specimen raised the possibility of an unusual progression of OFD-like adamantinoma to a classic adamantinoma.
  • The present case and the literature review suggest that an OFD-like adamantinoma may be a precursor lesion of classic adamantinoma.
  • Therefore, the possibility of progression of OFD-like adamantinoma to a classic adamantinoma should be kept in mind, particularly when the destructive changes are seen radiologically.
  • [MeSH-major] Adamantinoma / physiopathology. Bone Diseases, Developmental / physiopathology. Leg

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  • (PMID = 16636523.001).
  • [ISSN] 0040-8727
  • [Journal-full-title] The Tohoku journal of experimental medicine
  • [ISO-abbreviation] Tohoku J. Exp. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 19
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9. Jundt G, Reichart PA: [Malignant odontogenic tumors]. Pathologe; 2008 May;29(3):205-13
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  • [Title] [Malignant odontogenic tumors].
  • [Transliterated title] Maligne odontogene Tumoren.
  • Malignant odontogenic tumors are extremely rare.
  • As with benign odontogenic tumors, malignant epithelial odontogenic tumors or odontogenic carcinomas are distinguished from the even rarer mesenchymal ones, the odontogenic sarcomas.
  • Odontogenic carcinomas comprise ameloblastic carcinoma (AmCa), primary intraosseous carcinoma (PIOC), clear cell odontogenic carcinoma, odontogenic ghost cell carcinoma (OGCC), and the special case of metastasizing ameloblastoma.
  • Whereas metastasizing ameloblastoma can be diagnosed only after having metastasized, all other malignant odontogenic tumors present with atypia, increased cellularity and mitoses, and invasion.
  • [MeSH-minor] Ameloblastoma / classification. Ameloblastoma / pathology. Carcinoma / classification. Carcinoma / pathology. Carcinosarcoma / classification. Carcinosarcoma / pathology. Diagnosis, Differential. Humans. Jaw / pathology. Neoplasm Invasiveness. Sarcoma / classification. Sarcoma / pathology

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  • (PMID = 18392827.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
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10. Yoon HJ, Hong SP, Lee JI, Lee SS, Hong SD: Ameloblastic carcinoma: an analysis of 6 cases with review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Dec;108(6):904-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Microscopically, our cases showed malignant cytologic features with some histologic features of ameloblastoma.
  • Malignant cytologic features included nuclear pleomorphism, hyperchromatism, and high mitotic activity (33.3%).
  • [MeSH-major] Ameloblastoma / pathology. Carcinoma / pathology. Jaw Neoplasms / pathology. Neoplasm Recurrence, Local / pathology

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  • (PMID = 19800270.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 44
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11. Adeline VL, Dimba EA, Wakoli KA, Njiru AK, Awange DO, Onyango JF, Chindia ML: Clinicopathologic features of ameloblastoma in Kenya: a 10-year audit. J Craniofac Surg; 2008 Nov;19(6):1589-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathologic features of ameloblastoma in Kenya: a 10-year audit.
  • This study describes the clinical and pathologic features of ameloblastomas seen in the 2 main craniofacial treatment centers in Kenya in the 10-year period between January 1995 and December 2005.
  • There was no significant difference in gender presentation of ameloblastomas, although females presented at a slightly older age.
  • Most of the ameloblastomas (n = 172; 93.5%) were located in the mandible, 11 (6.0%) were in the maxilla, and 1 (0.5%) was in the soft tissues.
  • The posterior mandible was the most commonly affected site, whereas maxillary ameloblastomas tended to occur in anterior sites.
  • One hundred fifty-three ameloblastomas (83.2%) were of the solid/multicystic subtype; 8 (5.3%) were unicystic; 1 (0.5%) was of extraosseous origin; 1 (0.5%) was desmoplastic; 9 (6.0%) were malignant, and 12 of the records had no histopathologic pattern specified.
  • [MeSH-major] Ameloblastoma / epidemiology. Jaw Neoplasms / epidemiology. Medical Audit

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  • (PMID = 19098557.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Kumamoto H, Ooya K: Immunohistochemical detection of insulin-like growth factors, platelet-derived growth factor, and their receptors in ameloblastic tumors. J Oral Pathol Med; 2007 Apr;36(4):198-206
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Tissue specimens of 10 tooth germs, 47 ameloblastomas, and five malignant ameloblastic tumors were examined immunohistochemically with the use of antibodies against IGF-I, IGF-II, IGF-I receptor (IGF-IR), PDGF A-chain, PDGF B-chain, PDGF alpha-receptor, and PDGF beta-receptor.
  • RESULTS: Immunohistochemical reactivity for IGFs, PDGF chains, and their receptors was detected predominantly in odontogenic epithelial cells near the basement membrane in tooth germs and in benign and malignant ameloblastic tumors.
  • Malignant ameloblastic tumors showed higher reactivity for PDGF chains than benign ameloblastomas and higher reactivity for platelet-derived growth factor receptors than tooth germs.
  • The expression levels of PDGF chains were significantly higher in follicular ameloblastomas than in plexiform ameloblastomas.
  • Desmoplastic ameloblastomas showed higher expression of IGFs and IGF-IR when compared with other ameloblastoma subtypes.
  • Altered expression of the ligands and receptors in ameloblastic tumors may be involved in oncogenesis, malignant potential, and tumor cell differentiation.
  • [MeSH-major] Ameloblastoma / metabolism. Insulin-Like Growth Factor I / biosynthesis. Insulin-Like Growth Factor II / biosynthesis. Jaw Neoplasms / metabolism. Platelet-Derived Growth Factor / biosynthesis. Tooth Germ / metabolism

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  • (PMID = 17391297.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Platelet-Derived Growth Factor; 0 / Proto-Oncogene Proteins c-sis; 0 / Receptors, Somatomedin; 0 / platelet-derived growth factor A; 67763-96-6 / Insulin-Like Growth Factor I; 67763-97-7 / Insulin-Like Growth Factor II; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor beta; EC 2.7.10.1 / Receptors, Platelet-Derived Growth Factor
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13. Dimba EA, Gichana J, Limo AK, Wakoli KA, Chindia ML, Awange DO: An audit of oral diseases at a Nairobi centre, 2000-2004. Int Dent J; 2007 Dec;57(6):439-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The most common benign tumour was the ameloblastoma (50.23%: n = 109), which predominantly affected the mandible, and also occurred in male patients at a younger age (p = 0.023).
  • Peak incidences for malignant disease were observed in the sixth decade (mean age +/- SD = 46.94 +/- 18.99 years).
  • Oral squamous cell carcinoma (OSCC) was the most common malignant tumour (59.55%; n = 187); occurring in the tongue, floor of the mouth, buccal mucosa and palate.
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Aged, 80 and over. Ameloblastoma / epidemiology. Carcinoma, Squamous Cell / epidemiology. Child. Child, Preschool. Cysts / epidemiology. Female. Humans. Hyperplasia / epidemiology. Incidence. Infant. Infant, Newborn. Kenya / epidemiology. Male. Middle Aged. Mouth Neoplasms / epidemiology. Retrospective Studies. Sex Distribution

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  • (PMID = 18265777.001).
  • [ISSN] 0020-6539
  • [Journal-full-title] International dental journal
  • [ISO-abbreviation] Int Dent J
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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1
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4. Tincani AJ, Del Negro A, Araújo PP, Akashi HK, Neves Fda S, Martins AS: Head and neck reconstruction using infrahyoid myocutaneous flaps. Sao Paulo Med J; 2006 Sep 7;124(5):271-4
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  • Here we describe our experience with infrahyoid flaps (IHFs) employed to cover surgical defects in the oral cavity and oropharynx in patients with benign and malignant tumors.
  • Thirteen patients (92.8%) had squamous cell carcinoma (SCC) and one (7.2%) ameloblastoma.
  • The disease stage was T3 in eight (61.5%) of the SCC cases and T4 in five (38.5%).


15. Van Dam SD, Unni KK, Keller EE: Metastasizing (malignant) ameloblastoma: review of a unique histopathologic entity and report of Mayo Clinic experience. J Oral Maxillofac Surg; 2010 Dec;68(12):2962-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastasizing (malignant) ameloblastoma: review of a unique histopathologic entity and report of Mayo Clinic experience.
  • PURPOSE: To provide a comprehensive review of metastasizing (malignant) ameloblastoma, establish a new baseline of valid cases using histologic criteria and minimum documentation, and report 3 cases from the Mayo Clinic files.
  • PATIENTS AND METHODS: Ninety-eight original reports of "metastasizing," "malignant," or "atypical" ameloblastoma were reviewed.
  • The following data were gathered for reports that demonstrated well-differentiated ameloblastoma at the metastatic site: gender, ethnicity, age at time of primary tumor diagnosis, histologic pattern of primary tumor, anatomic sites of primary and metastatic tumors, interval from diagnosis of primary to diagnosis of metastasis, number of recurrences preceding metastasis, treatment responses to radiation and/or chemotherapy, presence of hypercalcemia, and length of survival after metastasis.
  • RESULTS: Twenty-seven valid reports of metastasizing (malignant) ameloblastoma were identified; 81% originated in the mandible, recurring on average 4 times before metastasis.
  • Those patients who had succumbed to their disease had an average survival time of 3 years after diagnosis of metastasis.
  • CONCLUSIONS: Metastasis of well-differentiated ameloblastoma occurs more rarely than previously believed.
  • Metastasis to the lungs bilaterally, by the hematogenous route, usually follows multiple failed attempts at primary tumor control.
  • The absence of malignant cytologic transformation correlates with relatively indolent metastatic site growth.
  • Treatment of metastasizing (malignant) ameloblastoma should include close observation, thoracotomy with wedge resections, or experimental chemotherapeutic combinations.
  • [MeSH-major] Ameloblastoma / secondary. Lung Neoplasms / secondary. Mandibular Neoplasms / pathology. Maxillary Neoplasms / pathology

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  • [Copyright] Copyright © 2010 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20970910.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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16. Jain D, Jain VK, Vasishta RK, Ranjan P, Kumar Y: Adamantinoma: a clinicopathological review and update. Diagn Pathol; 2008;3:8
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  • [Title] Adamantinoma: a clinicopathological review and update.
  • Adamantinoma is a primary low-grade, malignant bone tumor that is predominantly located in the mid-portion of the tibia.
  • The etiology of the tumor is still a matter of debate.
  • The initial symptoms of adamantinoma are often indolent and nonspecific and depend on location and extent of the disease.
  • Histologically, classic adamantinoma is a biphasic tumor characterized by epithelial and osteofibrous components that may be intermingled with each other in various proportions and differentiating patterns.
  • To assure the histological diagnosis, pathologists should employ immunohistochemistry for demonstrating the sometimes sparse epithelial cell nests when the radiological features are suggestive of adamantinoma.
  • There is paucity of compiled data over adamantinoma in the literature, hence authors tried to make a comprehensive review which must be of use to beginners and trained pathologists.
  • Our objective is to further define the clinicoradiologic features and pathologic spectra of adamantinoma.

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  • (PMID = 18279517.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2276480
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17. Lin C, Li J, Lu N: [Analysis of 2161 cases of neoplasm in oral maxillofacial region in Xinjiang]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2010 Sep;45(9):553-5
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  • METHODS: A total of 2161 patients with benign or malignant oral-maxillofacial tumors diagnosed in Department of Dentofacial Surgery of the First Affiliated Hospital of Xinjiang Medical College from 1995 to 2009 were analyzed retrospectively.
  • RESULTS: Of the 2161 cases, 58.49% (1264/2161) was benign tumors, 33.13% (716/2161) malignant tumors, and 8.38% (181/2161) tumor-like lesions.
  • The most common benign tumors were pleomorphic adenoma, hemangioma, papilloma, adenolymphoma and ameloblastoma.
  • Squamous cell carcinoma constituted the majority of the malignant tumors.
  • The most common malignant tumors of salivary gland were adenoid cystic carcinoma.
  • The most common odontogenic tumors was ameloblastoma.
  • The most common sites of malignant tumors were tongue, lip, parotiod gland and buccal mucosa.
  • There was more malignant tumors in Uygur nationality than in Han living in the same region.
  • [MeSH-minor] Adenolymphoma. Adenoma, Pleomorphic. Ameloblastoma. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / pathology. China / epidemiology. Face. Humans. Incidence. Mouth Mucosa. Odontogenic Tumors. Retrospective Studies. Salivary Gland Neoplasms

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  • (PMID = 21122451.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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18. van den Berg H, Slaar A, Kroon HM, Taminiau AH, Hogendoorn P: Results of diagnostic review in pediatric bone tumors and tumorlike lesions. J Pediatr Orthop; 2008 Jul-Aug;28(5):561-4
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  • PROCEDURE: All 262 bone tumor specimens of children up to the age of 19 years reviewed from 1999 to 2003 by the Netherlands Committee on Bone Tumors were included.
  • Thirteen of the 60 malignant tumors were not recognized as malignant.
  • Seven of 198 benign lesions were reclassified as malignant.
  • Kappa values were indicative for good agreement in the (by the Ministry of Health designated) bone tumor centers.
  • Adamantinomas were not recognized in non-bone tumor centers.
  • Specifically in non-bone tumor centers, the correctness of the initial diagnosis can be questioned.

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  • (PMID = 18580373.001).
  • [ISSN] 0271-6798
  • [Journal-full-title] Journal of pediatric orthopedics
  • [ISO-abbreviation] J Pediatr Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Parkins GE, Armah G, Ampofo P: Tumours and tumour-like lesions of the lower face at Korle Bu Teaching Hospital, Ghana--an eight year study. World J Surg Oncol; 2007;5:48
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  • Seventy eight (45.6%) of the patients presented with lesions that were classified as malignant of which 54 (62%) were diagnosed as squamous cell carcinoma (SCC).
  • Fifty-four (62%) of malignant tumours were squamous cell carcinoma; 58 (93.6%) of the benign odontogenic tumours were classified as ameloblastoma.
  • Malignant tumours were more commonly detected in patients between 41 and 70 years (63%).
  • Both malignant and benign tumours are seen in the Ghanaian population.
  • In the present study, SCC and ameloblastoma were the commonest malignant and benign odontogenic tumours seen respectively; the two representing more than 65% of all tumours.

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  • (PMID = 17484780.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1885260
  • [General-notes] NLM/ Original DateCompleted: 20070813
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20. Gleason BC, Liegl-Atzwanger B, Kozakewich HP, Connolly S, Gebhardt MC, Fletcher JA, Perez-Atayde AR: Osteofibrous dysplasia and adamantinoma in children and adolescents: a clinicopathologic reappraisal. Am J Surg Pathol; 2008 Mar;32(3):363-76
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  • [Title] Osteofibrous dysplasia and adamantinoma in children and adolescents: a clinicopathologic reappraisal.
  • Osteofibrous dysplasia (OFD) and adamantinoma are rare and most commonly arise in the tibia of young individuals.
  • Although OFD has typical histopathologic features, areas resembling OFD have often been noted at the periphery of otherwise classic adamantinomas, and some have suggested that OFD may be either a precursor to or a regressive phase of adamantinoma.
  • The so-called OFD-like adamantinoma encompasses some features of both OFD and adamantinoma.
  • We studied the clinical, imaging, histopathologic, immunohistochemical, ultrastructural, and molecular features of 16 OFD and 8 adamantinomas (5 OFD-like and 3 classic) in an attempt to further define their morphology, clinical course, and relationship.
  • Patients with OFD were generally younger than those with adamantinoma.
  • Osteoblastic and osteoclastic activity was more prominent in OFD than in OFD-like adamantinoma.
  • In addition to the inconspicuous small clusters of epithelial cells in OFD-like adamantinoma, isolated keratin-positive cells with a unique ultrastructural hybrid fibroblastic-epithelial phenotype were found in the stroma of all OFD and OFD-like adamantinomas.
  • Fluorescence in situ hybridization analysis revealed trisomies 7, 8, and/or 12 in the spindle cell stroma of OFD, OFD-like, and classic adamantinoma, supporting a neoplastic origin of OFD and a common histogenesis for all 3 lesions.
  • Of the 11 OFD patients with follow-up (median, 4.5 y), all 3 who underwent incisional biopsy had persistent, nonprogressive disease and 2 of 8 who underwent curettage or wide excision had recurrence; none developed adamantinoma.
  • All 6 adamantinoma patients with follow-up (3 classic and 3 OFD-like) were treated with wide excision.
  • One with classic adamantinoma died of pulmonary metastases 9 years after presentation; the other 5 were free of disease with a median follow-up of 12 years.
  • None of the classic adamantinomas evolved into OFD-like adamantinoma or OFD.
  • Although the histopathology, immunohistochemistry, ultrastructure, and cytogenetics indicate that these lesions are closely related, our data and the literature suggest that only classic adamantinoma has malignant potential.
  • OFD, OFD-like adamantinoma, and classic adamantinoma appear to show a progressive complexity of cytogenetic aberrations, perhaps indicative of a multistep neoplastic transformation.
  • [MeSH-major] Adamantinoma / pathology. Bone Neoplasms / pathology. Fibrous Dysplasia of Bone / pathology

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  • (PMID = 18300815.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Zhong M, Liu J, Gong YB, Liu JD, Wang J, Zhang B: [Expression of p21WAF1, p27KIP1 and cyclin E in ameloblastoma]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2005 Jul;40(4):306-9
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  • [Title] [Expression of p21WAF1, p27KIP1 and cyclin E in ameloblastoma].
  • OBJECTIVE: To investigate the expression of cyclin E mRNA, p21(WAF1) mRNA and p27(KIP1) protein in human ameloblastoma (AB), and to explore the clinical and biological characteristics of AB.
  • The expression of cyclin E mRNA increased with AB recurrence and malignant transformation, and the difference of expression among primary AB, recurrent AB, and malignant AB, was statistically significant.
  • [MeSH-major] Ameloblastoma / metabolism. Cyclin E / metabolism. Cyclin-Dependent Kinase Inhibitor p21 / metabolism. Intracellular Signaling Peptides and Proteins / metabolism. Jaw Neoplasms / metabolism. Oncogene Proteins / metabolism

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  • (PMID = 16191374.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / CCNE1 protein, human; 0 / CDKN1A protein, human; 0 / CDKN1B protein, human; 0 / Cyclin E; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Intracellular Signaling Peptides and Proteins; 0 / Oncogene Proteins; 0 / RNA, Messenger; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
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22. Nakano K, Siar CH, Tsujigiwa H, Nagatsuka H, Nagai N, Kawakami T: Notch signaling in benign and malignant ameloblastic neoplasms. Eur J Med Res; 2008 Oct 27;13(10):476-80
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  • [Title] Notch signaling in benign and malignant ameloblastic neoplasms.
  • BACKGROUND: In general, Notch is a representative signal which controls morphosis and differentiation of cells, but its role in human odontogenic neoplasms, especially in ameloblastoma and its malignant counterpart, ameloblastic carcinoma, is not known.
  • METHODS: We examined Notch1 peptide and its gene (mRNA) in an ameloblastoma (case 1: 27-year-old female, right mandibular tumor) and an ameloblastic carcinoma (case 2: 93-year-old female, right mandibular tumor), using immunohistochemistry (IHC) and in situ hybridization (ISH) techniques.
  • RESULTS: Notch1 intracellular domain (NICD) positive products were observed in the cells at the peripheral layer of most proliferating epithelial tumor nests in case 1.
  • CONCLUSIONS: Notch signaling plays some role in cytological differentiation or acquisition of tissue specific characteristics in neoplastic cells of odontogenic neoplasms, including ameloblastoma and ameloblastic carcinoma.
  • [MeSH-major] Ameloblastoma / genetics. Ameloblastoma / metabolism. Mandibular Neoplasms / genetics. Mandibular Neoplasms / metabolism. Receptor, Notch1 / genetics. Receptor, Notch1 / metabolism

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  • (PMID = 19008176.001).
  • [ISSN] 0949-2321
  • [Journal-full-title] European journal of medical research
  • [ISO-abbreviation] Eur. J. Med. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / NOTCH1 protein, human; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / Receptor, Notch1
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23. Yoshida K, Kawase T, Tomita T, Ogawa K, Kawana H, Yago K, Asanami S: Surgical strategy for tumors located in or extending from the intracranial space to the infratemporal fossa-Advantages of the transcranial approach (zygomatic infratemporal fossa approach) and the indications for a combined transcranial and transcervical approach-. Neurol Med Chir (Tokyo); 2009 Dec;49(12):580-6
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  • The inferior margin of infratemporal tumor could be accessed via the transcranial route with zygomatic or orbitozygomatic osteotomy without complications including facial nerve injury in nine cases, and the lowest level of the infratemporal tumors was approximately 4.5 cm below the outer surface of the middle cranial base.
  • In five of these 9 cases (2 schwannomas, 1 myxoma, 1 chondrosarcoma, and 1 malignant peripheral nerve sheath tumor), the tumors were localized in the infratemporal fossa, and in the other 4 cases (2 meningiomas, 1 glioblastoma, and 1 ameloblastoma), the tumors extended to both the intracranial space and the infratemporal fossa.
  • [MeSH-minor] Adult. Aged. Cranial Nerve Neoplasms / pathology. Cranial Nerve Neoplasms / radiography. Cranial Nerve Neoplasms / surgery. Cranial Nerves / anatomy & histology. Cranial Nerves / pathology. Cranial Nerves / surgery. Disease Progression. Female. Humans. Magnetic Resonance Imaging. Male. Meningioma / pathology. Meningioma / radiography. Meningioma / surgery. Middle Aged. Neck / anatomy & histology. Neck / surgery. Neoplasm Invasiveness / pathology. Neoplasm Invasiveness / physiopathology. Orbit / anatomy & histology. Orbit / surgery. Osteotomy / methods. Postoperative Complications / prevention & control. Retrospective Studies. Sarcoma / pathology. Sarcoma / radiography. Sarcoma / surgery. Skull Base Neoplasms / pathology. Skull Base Neoplasms / radiography. Skull Base Neoplasms / surgery. Tomography, X-Ray Computed. Treatment Outcome. Young Adult. Zygoma / anatomy & histology. Zygoma / surgery


24. Zhang Y, Ma XL, Zheng Y: [A case with malignant ameloblastoma of larynx]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 May;43(5):389-90
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  • [Title] [A case with malignant ameloblastoma of larynx].
  • [MeSH-major] Ameloblastoma. Laryngeal Neoplasms

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  • (PMID = 18717322.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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25. Papagelopoulos PJ, Savvidou OD, Mavrogenis AF, Galanis EC, Shaughnessy WJ, Unni KK, Sim FH: Lateral malleolus en bloc resection and ankle reconstruction for malignant tumors. Clin Orthop Relat Res; 2005 Aug;(437):209-18
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  • [Title] Lateral malleolus en bloc resection and ankle reconstruction for malignant tumors.
  • Four children and six adults required en bloc resection of the lateral malleolus for malignant tumors.
  • There were four osteosarcomas, three chondrosarcomas, two Ewing's sarcomas, and one adamantinoma.
  • At the latest followup, all 10 patients showed no evidence of disease.
  • Five patients who had primary or late ankle arthrodesis had a Musculoskeletal Tumor Society and International Society of Limb Salvage functional score of 28 points (92%), and two adolescents who had postoperative bracing alone had a functional score of 24 points (80%).

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  • (PMID = 16056051.001).
  • [ISSN] 0009-921X
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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26. Kumamoto H, Ooya K: Immunohistochemical detection of phosphorylated Akt, PI3K, and PTEN in ameloblastic tumors. Oral Dis; 2007 Sep;13(5):461-7
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  • METHODS: 11 tooth germs, 40 ameloblastomas, and 5 malignant ameloblastic tumors were examined immunohistochemically with antibodies against pAkt, PI3K, and PTEN.
  • Plexiform ameloblastomas showed significantly higher expression of PI3K than follicular ameloblastomas, and PI3K immunoreactivity in ameloblastomas without cellular variation was significantly higher than that in acanthomatous ameloblastomas.
  • The level of PTEN immunoreactivity was significantly lower in ameloblastomas than in tooth germs.
  • [MeSH-major] Ameloblastoma / chemistry. Jaw Neoplasms / chemistry. Membrane Proteins / analysis. Oncogene Protein v-akt / analysis. PTEN Phosphohydrolase / analysis

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  • (PMID = 17714348.001).
  • [ISSN] 1354-523X
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Membrane Proteins; EC 2.7.11.1 / Oncogene Protein v-akt; EC 3.1.3.48 / TPTE protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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27. Weinreb I, Goldstein D, Perez-Ordoñez B: Primary extraskeletal Ewing family tumor with complex epithelial differentiation: a unique case arising in the lateral neck presenting with Horner syndrome. Am J Surg Pathol; 2008 Nov;32(11):1742-8
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  • [Title] Primary extraskeletal Ewing family tumor with complex epithelial differentiation: a unique case arising in the lateral neck presenting with Horner syndrome.
  • An open biopsy demonstrated a high-grade malignant neoplasm with sheets of undifferentiated round cells infiltrating soft tissues and a large peripheral branch of the vagus nerve.
  • Focally, the tumor abruptly produced keratinizing cells and frank squamous pearls.
  • The tumor showed diffuse expression of CD99, high molecular weight keratin, p63, cytokeratin (CK) 5/6, AE1/AE3, CAM5.2, CK19, and focal CK14.
  • Subsequently, the tumor was shown to harbor the t(11;22) involving EWSR1 and FLI-1 by reverse transcription-polymerase chain reaction, characteristic of EFT's, which was confirmed by dual color break apart fluorescence in-situ hybridization analysis.
  • This tumor is related to, if not an example of the recently described "adamantinoma-like" EFT and demonstrates a potential diagnostic pitfall.
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Keratins / biosynthesis. Male. Membrane Proteins / biosynthesis. Oncogene Proteins, Fusion / genetics. Proto-Oncogene Protein c-fli-1 / genetics. RNA-Binding Protein EWS. Reverse Transcriptase Polymerase Chain Reaction. Translocation, Genetic. Vagus Nerve / pathology

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  • (PMID = 18769338.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / EWS-FLI fusion protein; 0 / Membrane Proteins; 0 / Oncogene Proteins, Fusion; 0 / Proto-Oncogene Protein c-fli-1; 0 / RNA-Binding Protein EWS; 68238-35-7 / Keratins
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28. Dao TV, Bastidas JA, Kelsch R, Kraut RA: Malignant ameloblastoma: a case report of a recent onset of neck swelling in a patient with a previously treated ameloblastoma. J Oral Maxillofac Surg; 2009 Dec;67(12):2685-9
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  • [Title] Malignant ameloblastoma: a case report of a recent onset of neck swelling in a patient with a previously treated ameloblastoma.
  • [MeSH-major] Ameloblastoma / diagnosis. Mandibular Neoplasms / diagnosis. Submandibular Gland Diseases / diagnosis

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  • (PMID = 19925992.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Kruse AL, Zwahlen RA, Grätz KW: New classification of maxillary ameloblastic carcinoma based on an evidence-based literature review over the last 60 years. Head Neck Oncol; 2009;1:31
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  • BACKGROUND: The ameloblastic carcinoma is a rare malignant odontogenic tumor which rather occurs in the mandible than in the maxilla.
  • Current classifications do not consider benign histopathological features at the primary and malignant features at the metastatic tumour site.
  • Whereas two cases did not reveal malignant histopathology at the primary, they revealed malignant features at their metastatic sites.
  • Nineteen of 26 patients (73,1%) were controlled during a median follow-up time of 54,3 months (6 to 156 months); 6 patients died of disease after a median time of 62,7 months (7 to 156 months) after initial diagnosis.
  • CONCLUSION: It is of utmost importance to be aware of that ameloblastomas may be capable to degenerate into a "malignant" disease with recurrence and metastasis.
  • [MeSH-major] Ameloblastoma / classification. Maxillary Neoplasms / classification

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  • (PMID = 19674470.001).
  • [ISSN] 1758-3284
  • [Journal-full-title] Head & neck oncology
  • [ISO-abbreviation] Head Neck Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2733136
  • [General-notes] NLM/ Original DateCompleted: 20100629
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30. Ohtsuru M: Expression of parathyroid hormone-related protein in ameloblastomas. Tokai J Exp Clin Med; 2005 Dec;30(4):233-9
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  • [Title] Expression of parathyroid hormone-related protein in ameloblastomas.
  • Parathyroid hormone-related protein (PTHrP) was first discovered as a causative protein for hypercalcemia, which is often seen in the malignant tumor.
  • The present study, therefore, sought to clarify the expression of PTHrP, parathyroid hormone (PTH) and PTH1R in ameloblastoma, using RT-PCR (N = 8), immunohistochemistry (N = 23) and ELISA (N = 11) techniques.
  • Expression of PTHrP was also seen in all of the 23 cases in ameloblastoma by immunohistochemistry.
  • PTH1R was observed on osteoblasts in bone around the tumor but no expression was observed on ameloblastoma cells in tumor parenchyma by immunohistochemistry.
  • PTH was not detected in ameloblastoma by RT-PCR, immunohistochemistory as well as ELISA.
  • In addition, hypercalcemia and increase of serum PTHrP level was observed in one case of 8 ameloblastomas.
  • It was suggested that PTHrP level may be associated with local bone infiltration and hypercalcemia in ameloblastoma.
  • [MeSH-major] Ameloblastoma / genetics. Ameloblastoma / metabolism. Jaw Neoplasms / genetics. Jaw Neoplasms / metabolism. Parathyroid Hormone-Related Protein / genetics. Parathyroid Hormone-Related Protein / metabolism

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  • (PMID = 16482944.001).
  • [ISSN] 0385-0005
  • [Journal-full-title] The Tokai journal of experimental and clinical medicine
  • [ISO-abbreviation] Tokai J. Exp. Clin. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / PTH1R protein, human; 0 / Parathyroid Hormone; 0 / Parathyroid Hormone-Related Protein; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / Receptor, Parathyroid Hormone, Type 1; 0 / Receptors, Parathyroid Hormone; SY7Q814VUP / Calcium
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31. Naik V, Kale AD: Ameloblastic carcinoma: a case report. Quintessence Int; 2007 Nov-Dec;38(10):873-9
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  • Ameloblastic carcinoma is a rare malignant lesion with characteristic histologic features and behavior that dictate a more radical surgical approach than does a simple ameloblastoma.
  • Clinically, ameloblastic carcinoma is more aggressive than most typical ameloblastomas with extensive local destruction, perforation of the cortical plate, extension into surrounding soft tissues, numerous recurrent lesions, and metastasis, usually to cervical lymph nodes.
  • The radiographic appearance of ameloblastic carcinoma is consistent with that of ameloblastoma except for occasional presence of some focal radiopacities, apparently reflecting dystrophic calcification.
  • Histologically, the tumor cells resemble cells seen in ameloblastoma but show cytologic atypia, cellular pleomorphism, nuclear hyperchromatism, mitoses, and vascular and neural invasion.
  • It is probable that ameloblastoma, like other tumors (such as carcinoid tumors and epithelial tumors of the ovary), shows a spectrum of histologic and biologic behavior ranging from benignity at one end to frank malignancy at the other.

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  • (PMID = 18197328.001).
  • [ISSN] 1936-7163
  • [Journal-full-title] Quintessence international (Berlin, Germany : 1985)
  • [ISO-abbreviation] Quintessence Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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32. Martano M, Damiano S, Restucci B, Paciello O, Russo V, Maiolino P: Nuclear morphometry in canine acanthomatous ameloblastomas and squamous cell carcinomas. Eur J Histochem; 2006 Apr-Jun;50(2):125-30
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  • [Title] Nuclear morphometry in canine acanthomatous ameloblastomas and squamous cell carcinomas.
  • The aim of this study was to evaluate whether morphometrical analysis can be of diagnostic value for canine acanthomatous ameloblastoma.
  • We calculated, by means of an automated image analyser, some morphometric nuclear parameters, in particular: mean nuclear area (MNA), mean nuclear perimeter (MNP), maximum and minimum diameters (MDx and MDm) coefficient of variation of the nuclear area (NACV), largest to smallest dimension ratio (LS ratio), and form factor (FF), in 8 canine acanthomatous ameloblastomas, and we compared these morphometric data to those of 13 squamous cell carcinomas of canine gingiva.
  • The results indicated a progressive increase of the MNA, NACV, MNP and MDm proceeding from acanthomatous ameloblastomas (MNA: 42.11+/-8.74; NACV: 28,36+/-7,23; MNP: 24.18+/- 2.68; MDm: 5.69+/-0.49) to squamous cell carcinomas (MNA:49,69+/-9,10; NACV: 30,89+/-7,75; MNP: 25.63+/-2.54; MDm: 6.64+/-0.73).
  • On the contrary, the LS ratio and the FF resulted greater in acanthomatous ameloblastomas (LS ratio: 1,63+/-0,12; FF: 1,13+/-0,002) than in SCCs (LS ratio: 1,40+/-0,12; FF:0.91+/-0.38).
  • Moreover, the MNA, MNP,MDx and MDm resulted similar (MNA: p=0.89; MNP: p=0,65; MDm: p=0,16; MDx: p=0,13) in a subset of four acanthomatous ameloblastomas with cellular atypia (MNA:49,01+/-6,88; MNP: 26,28+/-1,99; MDm: 6.08+/-0.41; MDx: 10.18+/-0.88) and in squamous cell carcinomas (MNA:49.69+/-9,10; MNP: 25.63+/-2.54; MDm: 6.64+/-0.73; MDx: 9.26+/-1.05).
  • While the NACV values resulted higher in typical acanthomatous ameloblastoma (29,99+/-6,06) than in atypical acanthomatous ameloblastoma (26,74+/-8,84) and similar to those of the SCCs (30,89+/-7,75).
  • These results seem to confirm that acanthomatous ameloblastoma is a malignant or potentially malignant lesion and emphasizes that nuclear morphometry analysis can be an useful diagnostic and prognostic method in canine oral pathology.
  • [MeSH-major] Ameloblastoma / veterinary. Carcinoma, Squamous Cell / veterinary. Cell Nucleus / pathology. Dog Diseases / diagnosis. Gingiva / pathology. Jaw Neoplasms / veterinary

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  • (PMID = 16864123.001).
  • [ISSN] 1121-760X
  • [Journal-full-title] European journal of histochemistry : EJH
  • [ISO-abbreviation] Eur J Histochem
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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33. Reid-Nicholson M, Teague D, White B, Ramalingam P, Abdelsayed R: Fine needle aspiration findings in malignant ameloblastoma: a case report and differential diagnosis. Diagn Cytopathol; 2009 Aug;37(8):586-91
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  • [Title] Fine needle aspiration findings in malignant ameloblastoma: a case report and differential diagnosis.
  • We present a case of malignant ameloblastoma presenting in the posterior mandible and cervical lymph nodes of an African American child.
  • This case is somewhat unusual in that the patient was an adolescent and presented with metastatic disease.
  • This partly clinical as well as cytologic diagnosis was facilitated by the presence of typical ameloblastoma cytology in multiple cervical lymph nodes adjacent to the histologically confirmed intraosseous ameloblastoma.
  • Although cytology is helpful in diagnosing ameloblastoma, its features are by no means definitive as there are several cytologic mimics.
  • A high index of suspicion is therefore necessary to confirm or exclude ameloblastoma when evaluating any jaw lesion and/or adjacent enlarged lymph nodes by cytologic examination.
  • Adequate sampling is paramount to accurate diagnosis, and is especially important when attempting to distinguish ameloblastoma from ameloblastic carcinoma.
  • [MeSH-major] Ameloblastoma / diagnosis. Ameloblastoma / pathology. Mandibular Neoplasms / diagnosis. Mandibular Neoplasms / pathology

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  • (PMID = 19373909.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. DeVilliers P, Liu H, Suggs C, Simmons D, Daly B, Zhang S, Raubenheimer E, Larsson A, Wright T: Calretinin expression in the differential diagnosis of human ameloblastoma and keratocystic odontogenic tumor. Am J Surg Pathol; 2008 Feb;32(2):256-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Calretinin expression in the differential diagnosis of human ameloblastoma and keratocystic odontogenic tumor.
  • Ameloblastoma is a benign, locally aggressive epithelial odontogenic tumor that has the potential to become malignant and produce metastasis to distant sites such as lungs and kidneys.
  • The histologic presentation can be, in some instances, mistaken for keratocystic odontogenic tumor (KCOT) (formerly known as odontogenic keratocyst).
  • The expression of calretinin [calbindin2 (CALB2)] was investigated on both ameloblastoma and KCOT.
  • Nineteen cases of ameloblastoma and 17 cases of KCOT were stained with calretinin antiserum 18-0211 (Zymed, San Francisco, CA).
  • All cases (100%) of ameloblastoma showed positive calretinin staining, restricted to the neoplastic epithelial component and none (0%) of the 17 KCOTs showed positive calretinin staining.
  • Gene expression profiling of ameloblastomas showed CALB2 expressed in the basal cell layer of columnar cells resembling preameloblasts, in all 5 of the ameloblastomas evaluated.
  • Taken together, the results of this study strongly support calretinin as a useful immunohistochemical marker for ameloblastoma and malignant ameloblastoma and it can also be used in the differential diagnosis of KCOT.
  • [MeSH-major] Ameloblastoma / diagnosis. Biomarkers, Tumor / metabolism. Jaw Neoplasms / diagnosis. Odontogenic Cysts / diagnosis. Odontogenic Tumors / diagnosis. S100 Calcium Binding Protein G / metabolism

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  • (PMID = 18223328.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / DE016079
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / S100 Calcium Binding Protein G
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35. Fujita S, Seki S, Fujiwara M, Ikeda T: Midkine expression correlating with growth activity and tooth morphogenesis in odontogenic tumors. Hum Pathol; 2008 May;39(5):694-700
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  • There was no difference in positive rate and intensity of MK between benign odontogenic tumors and their malignant counterparts.
  • Ameloblastoma showed MK localization in the peripheral columnar cells in budding processes from the parenchyma, which frequently expressed proliferating cell nuclear antigen.
  • MK was also preferentially expressed in keratinized cells in acanthomatous ameloblastoma and keratocystic odontogenic tumor.
  • No expression was found in tumor cells associated with production of dental hard tissues in odontogenic mixed tumors including odontoma.
  • [MeSH-minor] Adolescent. Adult. Aged. Ameloblastoma / pathology. Ameloblastoma / physiopathology. Female. Humans. Male. Middle Aged. Odontoma / pathology. Odontoma / physiopathology

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  • (PMID = 18329695.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MDK protein, human; 0 / Nerve Growth Factors
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36. Ram R: Ameloblastoma relapse after 16 years of resection in symphysis of mandible sparing the bone graft. Natl J Maxillofac Surg; 2010 Jul;1(2):190-3
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  • [Title] Ameloblastoma relapse after 16 years of resection in symphysis of mandible sparing the bone graft.
  • Ameloblastoma is a tumor derived from epithelium involved in odontogenesis.
  • Although it is considered a benign tumor, its clinical behavior may be regarded as lying between benign and malignant.
  • Diagnosis mainly from tissue biopsy and characteristic finding on plain X-rays does assist in differentiating between types of ameloblastoma.
  • The challenges in the management of this tumor are to provide complete excision as recurrence may occur in incomplete removal and also to reconstruct the bony defect in order to give reasonable cosmetic and functional outcome to the patient.

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  • (PMID = 22442598.001).
  • [ISSN] 2229-3418
  • [Journal-full-title] National journal of maxillofacial surgery
  • [ISO-abbreviation] Natl J Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3304200
  • [Keywords] NOTNLM ; Ameloblastoma relapse / epithelial odontogenic tumor / mandibular reconstruction
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37. Chandrasekar CR, Mohammed R, Rafalla AA, Grimer RJ: Adamantinoma of the calcaneum--a case report. Foot (Edinb); 2009 Mar;19(1):58-61
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  • [Title] Adamantinoma of the calcaneum--a case report.
  • Adamantinoma is rare, representing less than 1% of all primary malignant bone tumours.
  • It is a slow growing low grade malignant tumour which is often clinically, radiologically and histologically mistaken for many other tumours like Ewing's sarcoma, synovial sarcoma, fibrosarcoma, metastatic carcinoma, fibrous cortical defect and osteofibrous dysplasia.
  • Adamantinoma commonly occurs in the tibia.
  • Adamantinoma of the foot is extremely rare.
  • To our knowledge adamantinoma of the calcaneum has not been previously reported in the literature.
  • We report the case of a male patient, aged 33 years, who was treated for adamantinoma of the calcaneum and followed for 16 years highlighting the difficulty in diagnosis and management of this rare tumor occurring at a rare site.
  • [MeSH-major] Adamantinoma / pathology. Bone Neoplasms / pathology. Calcaneus / pathology

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  • (PMID = 20307451.001).
  • [ISSN] 1532-2963
  • [Journal-full-title] Foot (Edinburgh, Scotland)
  • [ISO-abbreviation] Foot (Edinb)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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38. Abada RL, Kadiri F, Tawfik N, Benchakroun N, Bouchbika Z, Chekkoury AI, Benchakroun Y, Benider A: [Multiple metastases of a mandibular ameloblastoma]. Rev Stomatol Chir Maxillofac; 2005 Jun;106(3):177-80
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  • [Title] [Multiple metastases of a mandibular ameloblastoma].
  • INTRODUCTION: Ameloblastoma is a benign odontogenic tumor which can be locally aggressive and invasive.
  • Metastases are rare but possible and must be considered as a malignant form of the tumor.
  • OBSERVATION: A 50-year-old woman presented a jugal metastasis of a mandibular ameloblastom which had been treated several times 28 years earlier.
  • DISCUSSION: The absence of any histological sign of malignity in the primary tumor and in the metastases, as observed in our patient, is remarkable.
  • Progression is very slow, like for the primary tumor.
  • Several factors predictive of metastasis have been described: female gender, age at onset of primary tumor (2nd to 3rd decade) and multiple local recurrences.
  • [MeSH-major] Ameloblastoma / secondary. Mandibular Neoplasms / pathology

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  • (PMID = 15976707.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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39. Szendroi M, Antal I, Arató G: Adamantinoma of long bones: a long-term follow-up study of 11 cases. Pathol Oncol Res; 2009 Jun;15(2):209-16
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  • [Title] Adamantinoma of long bones: a long-term follow-up study of 11 cases.
  • The aim of this study was to evaluate the clinicopathological features and prognostic significances of 11 histologically proven adamantinoma cases based on an average 12,7 year long follow-up.
  • The initial diagnosis at referral was other than adamantinoma in six patients (fibrous dysplasia, carcinoma metastasis, osteofibrous dysplasia, bone cyst, non-ossifying fibroma), referring to the differential diagnostic problems.
  • All adamantinoma were positive for cytokeratins often in coexpression with vimentin.
  • Intralesional curettage (2 pts) was followed by recurrence of the tumor.
  • One patient died 9 years after recognition of the tumor of pulmonary metastases.
  • Adamantinoma of the long bones is a low grade malignant tumor, which clinical outcome is difficult to predict based on histology or surgical stage of the tumor.
  • Wide surgical margin, e.g. resection the tumor reduces the rate of recurrence.
  • This study underlines that recurrences do occur even decades after recognition the tumor, therefore a life-long follow-up of the patient is necessary.
  • [MeSH-major] Adamantinoma / pathology. Bone Neoplasms / pathology. Tibia

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  • (PMID = 19048403.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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40. Roy Chowdhury SK, Ramen S, Chattopadhyay PK, Moorchung N, Rajkumar K: Ameloblastic Carcinoma of the mandible. J Maxillofac Oral Surg; 2010 Jun;9(2):198-201
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  • Odontogenic carcinomas are rare lesions arising from dental embryogenic residues and have been designated by a variety of terms like malignant ameloblastoma, ameloblastic carcinoma, metastatic ameloblastoma or primary intra-alveolar epidermoid carcinoma.
  • Ameloblastic carcinoma combines the histological features of ameloblastoma with cytological atypia, even in the absence of metastasis.
  • The lesion has been reported to arise either from the odontogenic cyst or the ameloblastoma.
  • Majority originate de novo and the remaining are malignant transformation of an ameloblastoma.

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  • (PMID = 22190787.001).
  • [ISSN] 0974-942X
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3244098
  • [Keywords] NOTNLM ; Ameloblastic carcinoma / Odontogenic malignancies
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41. Kumamoto H, Ooya K: Expression of tumor necrosis factor alpha, TNF-related apoptosis-inducing ligand, and their associated molecules in ameloblastomas. J Oral Pathol Med; 2005 May;34(5):287-94
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  • [Title] Expression of tumor necrosis factor alpha, TNF-related apoptosis-inducing ligand, and their associated molecules in ameloblastomas.
  • BACKGROUND: To clarify the roles of the apoptosis signaling pathway mediated by death receptors in oncogenesis and cytodifferentiation of odontogenic tumors, expression of tumor necrosis factor alpha (TNFalpha), TNF-related apoptosis-inducing ligand (TRAIL), and their associated molecules was analyzed in ameloblastomas as well as in tooth germs.
  • METHODS: Tissue specimens of 10 tooth germs, 40 benign ameloblastomas, and five malignant ameloblastomas were examined by reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry to determine the expression of TNFalpha, TNF receptor I (TNFRI), TRAIL, TRAIL receptor 1 (TRAIL-R1), TRAIL-R2, caspase-8, and nuclear factor-kappaB (NF-kappaB).
  • Expression of caspase-8 mRNA was identified in six of 33 ameloblastomas, but not in 10 tooth germs or one malignant ameloblastoma.
  • Epithelial expression of TNFalpha was focal in about 50% of tooth germs and ameloblastomas, and TNFalpha expression in neoplastic cells was significantly higher in follicular ameloblastomas than in plexiform ameloblastomas.
  • Expression of caspase-8 was found in some neoplastic cells in three of 37 ameloblastomas, but not in 10 tooth germs or five malignant ameloblastomas.
  • CONCLUSION: Expression of TNFalpha, TRAIL, and their receptors in tooth germs and ameloblastomas suggests that these death factors might be involved in cytodifferentiation of odontogenic epithelium and tissue structuring of ameloblastomas.
  • [MeSH-major] Ameloblastoma / metabolism. Apoptosis. Jaw Neoplasms / metabolism. Membrane Glycoproteins / biosynthesis. Tumor Necrosis Factor-alpha / biosynthesis
  • [MeSH-minor] Apoptosis Regulatory Proteins. Caspase 8. Caspases / biosynthesis. Humans. Immunoenzyme Techniques. NF-kappa B / biosynthesis. RNA, Messenger / analysis. Receptors, TNF-Related Apoptosis-Inducing Ligand. Receptors, Tumor Necrosis Factor / biosynthesis. Reverse Transcriptase Polymerase Chain Reaction. Signal Transduction. Statistics, Nonparametric. TNF-Related Apoptosis-Inducing Ligand. Tooth Germ / metabolism. Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / metabolism

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  • (PMID = 15817072.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / Membrane Glycoproteins; 0 / NF-kappa B; 0 / RNA, Messenger; 0 / Receptors, TNF-Related Apoptosis-Inducing Ligand; 0 / Receptors, Tumor Necrosis Factor; 0 / TNF-Related Apoptosis-Inducing Ligand; 0 / TNFRSF10A protein, human; 0 / TNFRSF10B protein, human; 0 / TNFSF10 protein, human; 0 / Tumor Necrosis Factor Receptor-Associated Peptides and Proteins; 0 / Tumor Necrosis Factor-alpha; EC 3.4.22.- / CASP8 protein, human; EC 3.4.22.- / Caspase 8; EC 3.4.22.- / Caspases
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42. Kumamoto H, Ooya K: Immunohistochemical detection of phosphorylated JNK, p38 MAPK, and ERK5 in ameloblastic tumors. J Oral Pathol Med; 2007 Oct;36(9):543-9
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  • METHODS: Ten tooth germs, 47 ameloblastomas, and 5 malignant ameloblastic tumors were examined immunohistochemically with the antibodies against p-JNK, p-p38 MAPK, and p-ERK5.
  • RESULTS: Immunoreactivity for p-JNK was detected in epithelial or neoplastic cells detached from the basement membrane in 7 tooth germs and 7 ameloblastomas, and the expression levels of p-JNK in ameloblastic tumors were significantly lower than that in tooth germs.
  • Expression of p-p38 MAPK was found in epithelial or neoplastic cells in tooth germs and ameloblastic tumors except for two ameloblastomas, and increased expression was found in keratinizing cells of acanthomatous ameloblastomas.
  • The expression level of p-p38 MAPK in ameloblastomas was significantly higher than the levels in tooth germs and malignant ameloblastic tumors.
  • The expression levels of p-ERK5 in ameloblastic tumors were slightly higher than that in tooth germs, and plexiform ameloblastomas showed significantly higher p-ERK5 expression than follicular ameloblastomas.
  • Altered expression of these phosphorylated MAPKs in ameloblastic tumors may be involved in oncogenesis and tumor cell differentiation.
  • [MeSH-major] Ameloblastoma / enzymology. Jaw Neoplasms / enzymology. Mitogen-Activated Protein Kinases / metabolism. Tooth Germ / enzymology

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  • (PMID = 17850438.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] EC 2.7.11.24 / JNK Mitogen-Activated Protein Kinases; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 7; EC 2.7.11.24 / Mitogen-Activated Protein Kinases; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases
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43. Kumamoto H, Ooya K: Immunohistochemical detection of BH3-only proteins in ameloblastic tumors. Oral Dis; 2008 Sep;14(6):550-5
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  • METHODS: Nine tooth germs, 37 ameloblastomas, and five malignant ameloblastic tumors were examined immunohistochemically with antibodies against Bid, Bim, Bad, Noxa, and Puma.
  • Acanthomatous ameloblastomas showed no reactivity for Bid, Bim, Bad, Noxa, or Puma in keratinizing cells, whereas granular cells in granular cell ameloblastomas reacted with these BH3-only proteins.
  • Basal and desmoplastic ameloblastomas and ameloblastic carcinomas showed immunoreactivity for the BH3-only proteins in most neoplastic cells.
  • Distinctive expression patterns of these BH3-only proteins in ameloblastoma variants suggest that the BH3-only proteins might be involved in tumor cell differentiation of ameloblastomas.
  • [MeSH-major] Ameloblastoma / pathology. Apoptosis Regulatory Proteins / analysis. Proto-Oncogene Proteins c-bcl-2 / analysis

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  • (PMID = 18826384.001).
  • [ISSN] 1601-0825
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / BAD protein, human; 0 / BBC3 protein, human; 0 / BH3 Interacting Domain Death Agonist Protein; 0 / BID protein, human; 0 / Bcl-2-like protein 11; 0 / Membrane Proteins; 0 / PMAIP1 protein, human; 0 / Proto-Oncogene Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / bcl-Associated Death Protein; 68238-35-7 / Keratins
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44. Fiaschetti V, Fanucci E, Rascioni M, Ottria L, Barlattani A, Simonetti G: Jaw expansive lesions: population incidence and CT dentalscan role. Oral Implantol (Rome); 2010 Jul;3(3):2-10
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  • THE TECHNIQUE SENSITIVITY WAS ASSESSED FOR TWO IMPORTANT CLASSES: benign and malignant lesions.
  • 656 patients (93.1 %) out of 704 examined for a suspicious lesion on the orthopantomography had a benign lesion: (127 follicular cysts (18.2 %), 181 radicular cysts (25.1%), 93 non odontogenic cysts (13.2%), 29 fibroma (4.2%), 198 odontomes (28.2%), 24 ameloblastoma (3.6%), 4 brown tumors (0.7%), 47 (6.9%) had malignant lesions: (12 carcinoma (1.7%), 29 metastasis (4.3%), 6 sarcoma (0.8%), 1 Dentascan CT resulted to be negative (1 false positive of digital OPT).

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  • (PMID = 23285385.001).
  • [ISSN] 1974-5648
  • [Journal-full-title] ORAL & implantology
  • [ISO-abbreviation] Oral Implantol (Rome)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC3399186
  • [Keywords] NOTNLM ; dentalscan / expansive lesions
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45. Kim K, Velez I, Kaltman SI, Lopez E, Stern D: Odontogenic carcinoma differentiation into rhabdomyosarcoma: report of a rare case. Quintessence Int; 2009 Nov-Dec;40(10):837-42
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  • Within the English-language literature, only 2 cases are reported of an odontogenic tumor with muscle differentiation: a benign odontogenic tumor (ameloblastoma) with differentiation into a rhabdomyosarcoma and an odontogenic sarcoma with smooth-muscle differentiation.
  • The general practitioner should be aware that odontogenic lesions may be malignant, even though this is extremely rare, and all tissue removed from the oral cavity should be submitted for biopsy.

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  • (PMID = 19898715.001).
  • [ISSN] 1936-7163
  • [Journal-full-title] Quintessence international (Berlin, Germany : 1985)
  • [ISO-abbreviation] Quintessence Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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51. Rastogi V, Pandilwar PK, Maitra S: Ameloblastoma: an evidence based study. J Maxillofac Oral Surg; 2010 Jun;9(2):173-7
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  • [Title] Ameloblastoma: an evidence based study.
  • OBJECTIVE: The purpose of this study is to present a series of 46 cases of ameloblastoma-38 in mandible and 8 in maxilla treated in the Oral and Maxillofacial Surgery Department of Government Dental College and Hospital, Nagpur during 1997-2006 with emphasis on various treatment modalities used in treating different types of ameloblastoma and how to define the safe margin for different clinical and histopathological types of ameloblastoma with their follow-up.
  • RESULT: In a follow-up period of 1-9 years recurrence was observed in six cases, two in patients treated with enucleation and curettage, three in patients treated with segmental resection and one in patient with peripheral ameloblastoma treated with soft tissue resection.

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  • (PMID = 22190781.001).
  • [ISSN] 0974-942X
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3244084
  • [Keywords] NOTNLM ; Ameloblastoma / Biopsy / Malignant / Mandible / Multicystic
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52. Abiko Y, Nagayasu H, Takeshima M, Yamazaki M, Nishimura M, Kusano K, Kitajo H, Saitoh M, Kawakami T, Chiba I, Kaku T: Ameloblastic carcinoma ex ameloblastoma: report of a case-possible involvement of CpG island hypermethylation of the p16 gene in malignant transformation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Jan;103(1):72-6
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  • [Title] Ameloblastic carcinoma ex ameloblastoma: report of a case-possible involvement of CpG island hypermethylation of the p16 gene in malignant transformation.
  • Ameloblastic carcinoma is described in the updated World Health Organization (WHO) classification as a rare malignant lesion.
  • Ameloblastic carcinoma meeting the WHO criteria may arise either as a result of malignant change in a pre-existing benign ameloblastoma (carcinoma ex ameloblastoma) or as a primary malignant ameloblastoma not preceded by an ordinary ameloblastoma (de novo carcinoma).
  • We report a case of ameloblastic carcinoma ex ameloblastoma and examine how this case underwent malignant transformation.
  • The DNA was extracted separately from benign and malignant areas in paraffin sections of the tumor.
  • Hypermethylation of CpG islands of the p16 gene was detected in the malignant parts of the tumor.
  • The results indicate that hypermethylation of p16 may have been involved in the malignant transformation of the ameloblastoma in the present case.
  • [MeSH-major] Ameloblastoma / genetics. Cell Transformation, Neoplastic / genetics. CpG Islands / genetics. DNA Methylation. Genes, p16. Mandibular Neoplasms / genetics

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  • (PMID = 17178497.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cadherins; 0 / DNA, Neoplasm; 0 / DNA-Binding Proteins; 0 / PDRG1 protein, human
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53. Donkor P, Bankas DO, Boakye G, Ansah S, Acheampong A: The use of free autogenous rib grafts in maxillofacial reconstruction. Ghana Med J; 2006;40(4):127-31
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  • The indications for grafting included ameloblastoma, malignant disease, cyst, ankylosis, and trauma.

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  • (PMID = 17568822.001).
  • [ISSN] 0016-9560
  • [Journal-full-title] Ghana medical journal
  • [ISO-abbreviation] Ghana Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ghana
  • [Other-IDs] NLM/ PMC1891270
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54. Flowers R, Baliga M, Guo M, Liu SS: Tibial adamantinoma with local recurrence and pulmonary metastasis: report of a case with histocytologic findings. Acta Cytol; 2006 Sep-Oct;50(5):567-73
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  • [Title] Tibial adamantinoma with local recurrence and pulmonary metastasis: report of a case with histocytologic findings.
  • BACKGROUND: Adamantinoma is a rare primary bone neoplasm of low malignant potential that may recur or metastasize in a mall percentage of patients.
  • The myriad histologic patterns may cause difficulty in distinguishing this tumor from other primary or metastatic neoplasms.
  • CASE: A 32-year-old man presented with a mass in the distal side of the left leg that was diagnosed as classic adamantinoma by open biopsy.
  • CONCLUSION: The diagnosis of adamantinoma requires knowledge of compatible clinical and radiologic studies as well as understanding of the variable histologic patterns that one may encounter.
  • Fine needle aspiration biopsy is particularly useful in the diagnosis of recurrent and metastatic adamantinoma.
  • This case report describes a distinctive cytomorphologic feature of nuclear grooves that may be a useful aid in distinguishing the tumor cells of adamantinoma from other cell types.
  • [MeSH-major] Adamantinoma / diagnosis. Bone Neoplasms / diagnosis. Lung / pathology. Lung Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis. Tibia / pathology
  • [MeSH-minor] Adult. Amputation. Biomarkers, Tumor / analysis. Biomarkers, Tumor / biosynthesis. Biopsy, Fine-Needle. Cell Shape. Diagnosis, Differential. Disease Progression. Epithelial Cells / pathology. Humans. Magnetic Resonance Imaging. Male. Nuclear Envelope / pathology. Prognosis

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  • (PMID = 17017449.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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55. Zhang L, Chen XM, Sun ZJ, Bian Z, Fan MW, Chen Z: Epithelial expression of SHH signaling pathway in odontogenic tumors. Oral Oncol; 2006 Apr;42(4):398-408
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  • Recent studies indicate that SHH signaling pathway activation occurs both in the odontogenic cyst and ameloblastoma.
  • However, the association of SHH pathway with other subtypes of odontogenic tumor is not well documented.
  • Odontogenic tumor tissues including 34 epithelial derived, 24 epithelial-mesenchymal derived, and 26 mesenchymal derived were examined by immunohistochemistry for SHH, PTC, SMO and GLI1.
  • Mesenchymal derived odontogenic tumors showed no positive staining except for the focal epithelial cells in island or cord forms within the central portion of the tumor.
  • The protein expression of SHH signaling pathway in malignant odontogenic tumors was no stronger than that in benign tumors.
  • Each of the genes in the pathway was expressed in similar patterns in the same tumor subtype.
  • Immunoreactivity for GLI1 was also detected in the base membrane of the tumor cells.

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  • (PMID = 16376138.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Hedgehog Proteins; 0 / Neoplasm Proteins
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56. Devenney-Cakir B, Dunfee B, Subramaniam R, Sundararajan D, Mehra P, Spiegel J, Sakai O: Ameloblastic carcinoma of the mandible with metastasis to the skull and lung: advanced imaging appearance including computed tomography, magnetic resonance imaging and positron emission tomography computed tomography. Dentomaxillofac Radiol; 2010 Oct;39(7):449-53
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  • Ameloblastic carcinoma is a very rare malignant odontogenic tumour with characteristic histopathological and clinical features, which requires aggressive surgical treatment and surveillance and, therefore, differs from ameloblastoma.

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  • (PMID = 20841465.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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  • [Other-IDs] NLM/ PMC3520182
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57. Piña-Oviedo S, Del Valle L, Padilla-Longoria R, Mendoza-Ramón H, Ortiz-Hidalgo C: Primary adamantinoma of the rib. Unusual presentation for a bone neoplasm of uncertain origin. Pathol Oncol Res; 2008 Dec;14(4):497-502
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  • [Title] Primary adamantinoma of the rib. Unusual presentation for a bone neoplasm of uncertain origin.
  • Adamantinomas are rare, low-grade malignant intra-osseous tumors composed of epithelial and mesenchymal elements, which show a marked predilection for the tibia and fibula of young adult male patients.
  • Although cases of adamantinoma located to the axial skeleton have been reported either as recurrent or metastatic disease, only two cases of primary adamantinoma located to the thoracic wall have been previously described.
  • In this study we present the clinical, radiological and histopathological features of a 24-year-old male with a slow growing, solid-cystic, painful mass, located to the right 11th rib, which was morphological and immunohistochemically diagnosed as a primary classic adamantinoma.
  • Primary affection of the rib is an unusual feature of classic adamantinomas.
  • [MeSH-major] Adamantinoma / pathology. Ribs / pathology

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  • (PMID = 18409022.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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58. Sharma S, Kumar D, Vashistha A, Bihani U, Trehan M: Recurrent unicystic ameloblastoma of the infratemporal and temporal fossa. Int J Clin Pediatr Dent; 2009 Jan;2(1):33-8
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  • [Title] Recurrent unicystic ameloblastoma of the infratemporal and temporal fossa.
  • The ameloblastoma has been described as benign but locally invasive; benign and locally invasive with strong tendency to recur; and locally malignant.

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  • (PMID = 25206097.001).
  • [ISSN] 0974-7052
  • [Journal-full-title] International journal of clinical pediatric dentistry
  • [ISO-abbreviation] Int J Clin Pediatr Dent
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC4086554
  • [Keywords] NOTNLM ; Unicystic / ameloblastoma / infratemporal temporal.
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59. Aregbesola SB, Ugboko VI, Akinwande JA, Arole GF, Fagade OO: Orofacial tumours in suburban Nigerian children and adolescents. Br J Oral Maxillofac Surg; 2005 Jun;43(3):226-31
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  • Of the 146 tumours 74 (51%) were malignant and 72 (49%) were benign.
  • The most common benign soft tissue and jaw tumours were gingival epulis and ameloblastoma respectively.
  • Of the malignant tumours 67 were lymphomas, 5 sarcomas and 2 carcinomas.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Ameloblastoma / epidemiology. Burkitt Lymphoma / epidemiology. Carcinoma / epidemiology. Child. Child, Preschool. Female. Fibrous Dysplasia of Bone / epidemiology. Gingival Diseases / epidemiology. Hemangioma / epidemiology. Humans. Infant. Infant, Newborn. Jaw Diseases / epidemiology. Jaw Neoplasms / epidemiology. Male. Nigeria / epidemiology. Odontogenic Tumors / epidemiology. Retrospective Studies. Sarcoma / epidemiology

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  • (PMID = 15888358.001).
  • [ISSN] 0266-4356
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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60. Fernandes AM, Duarte EC, Pimenta FJ, Souza LN, Santos VR, Mesquita RA, de Aguiar MC: Odontogenic tumors: a study of 340 cases in a Brazilian population. J Oral Pathol Med; 2005 Nov;34(10):583-7
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  • The most frequent tumor was ameloblastoma (45.2%), followed by odontomas (24.91%), and myxomas (9.1%).
  • CONCLUSIONS: Odontogenic tumors are uncommon lesions in this Brazilian population and malignant OTs are very rare.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Ameloblastoma / epidemiology. Brazil / epidemiology. Child. Child, Preschool. Female. Humans. Infant. Male. Mandibular Neoplasms / epidemiology. Maxillary Neoplasms / epidemiology. Middle Aged. Odontogenic Cyst, Calcifying / epidemiology. Odontoma / epidemiology. Retrospective Studies. Sex Factors

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  • (PMID = 16202077.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
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61. Van Rijn R, Bras J, Schaap G, van den Berg H, Maas M: Adamantinoma in childhood: report of six cases and review of the literature. Pediatr Radiol; 2006 Oct;36(10):1068-74
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  • [Title] Adamantinoma in childhood: report of six cases and review of the literature.
  • BACKGROUND: Adamantinoma is a rare slow-growing malignant bone tumour.
  • MATERIALS AND METHODS: The database of the Working Group on Paediatric Oncology, Academic Medical Centre/Emma Children's Hospital Amsterdam, was searched for cases of adamantinoma.
  • Additionally a literature study was performed to identify cases of adamantinoma in childhood.
  • RESULTS: We identified six local cases of adamantinoma of the long bones, two boys (age 3 and 8 years) and four girls (mean age 8.8 years, range 3.0-14.0 years).
  • On follow-up (mean 6.1 years, range 1.6-12.0 years) all children remained disease-free.
  • Besides a discussion of our six patients, imaging features, histopathology, surgical approach and a literature review of childhood adamantinomas is presented.
  • CONCLUSION: Although the incidence of adamantinoma is low, it is important to recognize this rare bone tumour, since in the early stages of the disease adequate treatment will result in an excellent prognosis.
  • [MeSH-major] Adamantinoma / diagnosis

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  • (PMID = 16906392.001).
  • [ISSN] 0301-0449
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 59
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62. Mukhopadhyay S, Raha K, Mondal SC: Huge ameloblastoma of jaw-A case report. Indian J Otolaryngol Head Neck Surg; 2005 Jul;57(3):247-8
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  • [Title] Huge ameloblastoma of jaw-A case report.
  • Ameloblastoma is a tumor of odontogenic epithelium.
  • It is a tumour of intermediate malignant potential which lies in the gray zone between benign and malignant neoplasm.
  • A huge ameloblastoma revealing benign cytological features in FNAC is being reported.Ameloblastoma arises from odontogenic epithelium.
  • This tumor can occur at any age.
  • This tumor shows invasive property and a remarkable tendency of recurrence.
  • The cases showing distant metastasis are recognized as malignant ameloblastoma.
  • Ameloblastic carcinoma is a tumor with microscopic features of ameloblastoma that displays malignant features at cytological level.([2]) It usually has aggressive course.
  • A case of large ameloblastoma with slow clinical course and benign cytological as well as histological features is being reported.

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  • [Cites] Oral Surg Oral Med Oral Pathol. 1984 Feb;57(2):168-76 [6366686.001]
  • (PMID = 23120181.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3451340
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63. Zhong M, Wang J, Gong YB, Li JC, Zhang B, Hou L: [Expression of HOXC13 in ameloblastoma]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2007 Jan;42(1):43-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Expression of HOXC13 in ameloblastoma].
  • OBJECTIVE: To study the expression of HOXC13 mRNA in ameloblastoma (AB), and to investigate its biological significance.
  • METHODS: HOXC13 mRNA was examined in 47 cases of AB (primary AB 29 cases, recurrent AB 14 cases, malignant AB 4 cases).
  • 2 cases of fibrous dysplasia of bone, 10 cases of keratocystic odontogenic tumor (KCOT) and 7 cases of normal oral mucosa were selected as control.
  • [MeSH-major] Ameloblastoma / genetics. Homeodomain Proteins / metabolism

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  • (PMID = 17331444.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / HOXC13 protein, human; 0 / Homeodomain Proteins; 0 / RNA, Messenger
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64. Ladeinde AL, Ogunlewe MO, Bamgbose BO, Adeyemo WL, Ajayi OF, Arotiba GT, Akinwande JA: Ameloblastoma: analysis of 207 cases in a Nigerian teaching hospital. Quintessence Int; 2006 Jan;37(1):69-74
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  • [Title] Ameloblastoma: analysis of 207 cases in a Nigerian teaching hospital.
  • OBJECTIVE: The aim of the study was to review all the cases of ameloblastoma seen at the Oral and Maxillofacial Surgery Clinic of the Lagos University Teaching Hospital, Nigeria, between 1980 and 2003.
  • METHODS AND MATERIALS: In this retrospective study, case files and biopsy reports of new cases of ameloblastoma covering a 24-year period were retrieved and analyzed for sex, age on presentation, histologic type, and site distribution.
  • RESULTS: A total of 207 cases of ameloblastoma were seen in the given period.
  • One hundred and ninety-eight (95.7%) were benign, and 9 (4.3%) were malignant.
  • The average ages on presentation for ameloblastoma and ameloblastic carcinoma were 31.67 and 46.44 years, respectively.
  • The most common histologic type was follicular ameloblastoma (25.1%).
  • CONCLUSIONS: Ameloblastoma with a predilection for the posterior mandibular region is relatively common in our environment.
  • [MeSH-major] Ameloblastoma / epidemiology. Mandibular Neoplasms / epidemiology

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  • (PMID = 16429706.001).
  • [ISSN] 0033-6572
  • [Journal-full-title] Quintessence international (Berlin, Germany : 1985)
  • [ISO-abbreviation] Quintessence Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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65. Senra GS, Pereira AC, Murilo dos Santos L, Carvalho YR, Brandão AA: Malignant ameloblastoma metastasis to the lung: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2008 Feb;105(2):e42-6
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  • [Title] Malignant ameloblastoma metastasis to the lung: a case report.
  • Ameloblastoma is an odontogenic tumor, usually benign, which rarely metastasizes to distant organs.
  • The case of a 27-year-old white woman is described, who presented a metastatic pulmonary ameloblastoma 7 years after the removal of a mandibular ameloblastoma.
  • Computed tomography (CT) revealed a 2-cm well-defined solitary round nodule without calcifications, leading to the hypothesis of a metastatic tumor.
  • Clinical and CT investigation confirmed no ameloblastoma recurrence in the jaw and no other primary tumor.
  • The diagnosis of metastatic ameloblastoma was confirmed by microscopic evaluation of the pulmonary nodule.
  • [MeSH-major] Ameloblastoma / secondary. Lung Neoplasms / secondary. Mandibular Neoplasms / pathology

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  • (PMID = 18230377.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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66. Geha H, Boland FX, Francois A, Tardif A, Peron JM: [Polymorphous low-grade adenocarcinoma of the maxilla simulating an odontogenic cyst]. Rev Stomatol Chir Maxillofac; 2010 Apr;111(2):105-7
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  • INTRODUCTION: In 1990, the WHO classified Polymorphous Low Grade Adenocarcinoma as a low-grade malignant tumor of the minor salivary glands.
  • This tumor often originates from the hard or soft palate minor salivary glands.
  • Ameloblastoma was suggested on macroscopic findings; nevertheless, the pathologic end diagnosis was Polymorphic Low-Grade Adenocarcinoma of minor salivary gland origin.

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  • (PMID = 20347466.001).
  • [ISSN] 1776-257X
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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67. Suomalainen A, Hietanen J, Robinson S, Peltola JS: Ameloblastic carcinoma of the mandible resembling odontogenic cyst in a panoramic radiograph. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006 May;101(5):638-42
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  • Ameloblastic carcinoma is a rare odontogenic tumor exhibiting histologic evidence of malignancy in the primary or recurrent tumor, regardless of whether it has metastasized or not.
  • Most ameloblastic carcinomas are presumed to have arisen de novo, with few cases of malignant transformation of ameloblastoma being apparent.

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  • (PMID = 16632277.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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68. Ladeinde AL, Ajayi OF, Ogunlewe MO, Adeyemo WL, Arotiba GT, Bamgbose BO, Akinwande JA: Odontogenic tumors: a review of 319 cases in a Nigerian teaching hospital. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2005 Feb;99(2):191-5
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  • Three hundred and eight (96.6%) were intraosseous, and 11 (3.4%) were peripheral (peripheral odontogenic fibroma=7; peripheral myxoma=3; peripheral ameloblastoma=1).
  • Among these cases, 96.6% of the tumors were benign and 3.4% were malignant.
  • Ameloblastoma with predilection for the mandible was the most frequent odontogenic tumor (63%), followed by adenomatoid odontogenic tumor (AOT) (7.5%), myxoma (6.5%), calcifying epithelial odontogenic cyst (5.3%), and odontogenic fibroma (5.3%).
  • More cases of malignant odontogenic tumors were seen than cases of calcifying epithelial odontogenic tumor and odontomas.
  • The mean ages of patients with AOT, ameloblastic fibroma, and odontoma were significantly lower than those with ameloblastoma ( P<.05).
  • No significant difference was found between the mean ages of patients with benign odontogenic tumors and those with malignant odontogenic tumors ( P=.058).
  • CONCLUSIONS: Odontogenic tumors, especially ameloblastoma, are not considered rare among Nigerians, whereas odontoma, regarded as the most frequent odontogenic tumor in North and South America, is rare.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Ameloblastoma / epidemiology. Child. Child, Preschool. Female. Hospitals, Teaching / statistics & numerical data. Humans. Jaw Neoplasms / epidemiology. Male. Mandibular Neoplasms / epidemiology. Middle Aged. Myxoma / epidemiology. Nigeria / epidemiology. Odontogenic Cyst, Calcifying / epidemiology. Odontoma / epidemiology. Retrospective Studies

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  • (PMID = 15660091.001).
  • [ISSN] 1079-2104
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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69. Izquierdo FM, Ramos LR, Sánchez-Herráez S, Hernández T, de Alava E, Hazelbag HM: Dedifferentiated classic adamantinoma of the tibia: a report of a case with eventual complete revertant mesenchymal phenotype. Am J Surg Pathol; 2010 Sep;34(9):1388-92
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  • [Title] Dedifferentiated classic adamantinoma of the tibia: a report of a case with eventual complete revertant mesenchymal phenotype.
  • Adamantinomas of the long bones are low-grade malignant tumours.
  • We report a case of an adamantinoma with a revertant sarcomatoid transformation that showed a complete loss of epithelial differentiation.
  • On the en bloc resection specimen, areas of classic adamantinoma were found but most of the tumor corresponded to a high-grade neoplasm with 2 histologic patterns: one made up by epithelial nests with a basaloid arrangement and positive for pankeratins and so-called glandular keratins, and a second sarcomatoid component, negative for these epithelial markers.
  • Five months after surgery the patient had a massive relapse that consisted solely of the second sarcomatous component also negative for epithelial antibodies.Three cases of adamantinomas with sarcomatoid transformation of the epithelial component have been described but the tumours still preserved an epithelial immunophenotype.
  • However, our case represents the extreme end of the sarcomatoid dedifferentiation of a classic adamantinoma with complete sarcomatoid transformation and total loss of epithelial markers.
  • [MeSH-major] Adamantinoma / pathology. Bone Neoplasms / pathology. Sarcoma / pathology. Tibia / pathology
  • [MeSH-minor] Adult. Biomarkers / metabolism. Biomarkers, Tumor / metabolism. Cell Transformation, Neoplastic. Humans. Keratins / metabolism. Male. Mesoderm / pathology. Neoplasms, Second Primary. Phenotype. Treatment Outcome

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  • (PMID = 20717000.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Biomarkers, Tumor; 0 / CAM 5.2 antigen; 68238-35-7 / Keratins
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70. Yuan XP, Xie BK, Lin XF, Liang BL, Zhang F, Li JT: [Value of multi-slice spiral CT with three-dimensional reconstruction in the diagnosis of neoplastic lesions in the jawbones]. Nan Fang Yi Ke Da Xue Xue Bao; 2008 Aug;28(9):1700-2, 1706
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  • [Title] [Value of multi-slice spiral CT with three-dimensional reconstruction in the diagnosis of neoplastic lesions in the jawbones].
  • OBJECTIVE: To assess the value of multi-slice spiral CT (MSCT) with three dimensional (3D) reconstruction in the diagnosis of neoplastic lesions in the jawbones.
  • Of these patients, 14 had ameloblastoma, 8 had hemangioma, 3 had osteosarcoma, 3 had ossifying fibroma, 2 had chondrosarcoma, 2 had fibrosarcoma, and 1 had odontogenic myxoma.
  • Benign tumors were most visualized as bone expansion changes with well defined ovoid or lobulated borderlines, and malignant ones often resulted in adjacent bony destruction and soft tissue masses.
  • CONCLUSION: MSCT examination is useful in defining the scope of tumor involvement and bony changes to help in the definite diagnosis, differential diagnosis and choice of clinical treatment.
  • Two-dimensional imaging, MPR, VRT and CRP have their respective advantages and limitations in showing jawbone tumor, and their combination can be of great clinical value.
  • [MeSH-minor] Adolescent. Adult. Ameloblastoma / diagnosis. Female. Hemangioma / diagnosis. Humans. Male. Middle Aged. Reproducibility of Results. Sensitivity and Specificity. Young Adult

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  • (PMID = 18819902.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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71. Miyake T, Tanaka Y, Kato K, Tanaka M, Sato Y, Ijiri R, Inayama Y, Ito Y, Aoki S, Kawabe R, Tohnai I: Gene mutation analysis and immunohistochemical study of beta-catenin in odontogenic tumors. Pathol Int; 2006 Dec;56(12):732-7
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  • Six ameloblastomas (five follicular ameloblastomas and one plexiform ameloblastoma) and three malignant odontogenic tumors (one metastasizing ameloblastoma, one ameloblastic carcinoma, and one primary intraosseous odontogenic carcinoma) were investigated for CTNNB1 expression and CTNNB1 mutation.
  • Immunohistochemically, all follicular ameloblastomas and one primary intraosseous odontogenic carcinoma exhibited focal and moderate nuclear/cytoplasmic expression of CTNNB1, whereas the plexiform ameloblastoma and the remaining two malignant odontogenic tumors had entirely membranous expression.
  • CTNNB1 mutation at codon 40 of exon 3 was found in one of the six follicular ameloblastomas.
  • The other five follicular ameloblastomas, the plexiform ameloblastoma, and the three malignant odontogenic tumors did not show mutation in exon 3 of CTNNB1.
  • These findings further confirmed that CTNNB1 mutation is not frequent in ameloblastoma and malignant odontogenic tumors, although the abnormality of Wnt signaling may be associated with some of these tumors.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Ameloblastoma / genetics. Ameloblastoma / pathology. Base Sequence. Child. DNA Mutational Analysis. Female. Humans. Immunohistochemistry. Male. Middle Aged. Molecular Sequence Data. Polymerase Chain Reaction

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  • (PMID = 17096730.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / beta Catenin
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72. Frey SP, Hardes J, Ahrens H, Winkelmann W, Gosheger G: Total tibia replacement using an allograft (in a patient with adamantinoma). Case report and review of literature. J Cancer Res Clin Oncol; 2008 Apr;134(4):427-31
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  • [Title] Total tibia replacement using an allograft (in a patient with adamantinoma). Case report and review of literature.
  • INTRODUCTION: Adamantinoma is a very rare, low-grade, malignant bone tumour that accounts for approximately 0.4% of all primary bone tumours.
  • Radiographically, adamantinomas vary in length, have a clearly defined outline, with a bubbly appearance and increase the width of the bone.
  • CASE PRESENTATION: We present a case of adamantinoma of the tibia, in which a resection of the whole tibia and reconstruction with a total tibia allograft was necessary.
  • It is often difficult to distinguish an adamantinoma from other tumours.
  • The most frequent described method to treat adamantinoma is wide resection and the use of an allograft.
  • [MeSH-major] Adamantinoma / surgery. Tibia / surgery

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  • (PMID = 18060426.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 16
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73. Most MJ, Sim FH, Inwards CY: Osteofibrous dysplasia and adamantinoma. J Am Acad Orthop Surg; 2010 Jun;18(6):358-66
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  • [Title] Osteofibrous dysplasia and adamantinoma.
  • Adamantinoma (AD) is a rare, low-grade malignant primary bone tumor that occurs most often in the tibia and/or fibula of adolescent persons and young adults; however, it has been reported in other long bones, as well.
  • More recently, published reports have described another clinical entity-differentiated or OFD-like AD-that appears to lie between OFD and AD along a spectrum of disease.
  • [MeSH-major] Adamantinoma / pathology. Adamantinoma / surgery. Bone Neoplasms / pathology. Bone Neoplasms / surgery. Fibrous Dysplasia of Bone / pathology. Fibrous Dysplasia of Bone / surgery

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  • (PMID = 20511441.001).
  • [ISSN] 1067-151X
  • [Journal-full-title] The Journal of the American Academy of Orthopaedic Surgeons
  • [ISO-abbreviation] J Am Acad Orthop Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 46
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74. Luo HY, Li TJ: Odontogenic tumors: a study of 1309 cases in a Chinese population. Oral Oncol; 2009 Aug;45(8):706-11
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  • Of the 1309 OTs, 94.04% were benign and 5.06% were malignant.
  • The most frequent benign tumor was keratocystic odontogenic tumor (38.73%), followed by ameloblastoma (36.52%) and odontomas (6.11%).
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Ameloblastoma / epidemiology. Child. Child, Preschool. China / epidemiology. Female. Humans. Infant. Male. Mandibular Diseases / epidemiology. Maxillary Diseases / epidemiology. Middle Aged. Odontogenic Cysts / epidemiology. Odontoma / epidemiology. Prevalence. Young Adult

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  • (PMID = 19147397.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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75. Essaadi M, Sif A, Benzaouia A, Rouadi S, Abada RL, Mahtar M, Roubal M, Janah A, Kadiri F, Rifki A: [Recurrent ameloblastoma on a rib graft after 33 years (a case report and review of the literature)]. Rev Laryngol Otol Rhinol (Bord); 2010;131(4-5):303-6
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  • [Title] [Recurrent ameloblastoma on a rib graft after 33 years (a case report and review of the literature)].
  • INTRODUCTION: The recurrence of an ameloblastoma is generally due to insufficient margins of resection or to the aggressiveness of the tumour which is regarded as locally malignant.
  • We report the case of a recurrent ameloblastoma on autologus rib graft which occurred 33 years after the surgery.
  • The histopathologic diagnosis was an ameloblastoma with healthy limits and without invasion of the soft tissues.
  • CONCLUSION: The pathogenesis of the recurrence of an ameloblastoma on autologus osseous graft is still not well understood.
  • [MeSH-major] Ameloblastoma / pathology. Mandibular Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Ribs / transplantation

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  • (PMID = 21866745.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
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76. Angiero F, Borloni R, Macchi M, Stefani M: Ameloblastic carcinoma of the maxillary sinus. Anticancer Res; 2008 Nov-Dec;28(6B):3847-54
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  • Ameloblastic carcinoma is a very rare malignant odontogenic neoplasm of the mandible and maxilla, accounting for some 66 reported cases.
  • The initial microscopic evaluation of the biopsy and radiographic findings were consistent with benign peripheral ameloblastoma without cellular atypia and extensive fields of acantomatous pattern, but immunohistochemical investigation found strong positivity for Bcl-2, cytokeratins CAM 5 and 6, and for Ki-67/MIB-1, changing our diagnosis.
  • [MeSH-major] Ameloblastoma / diagnosis. Maxillary Sinus Neoplasms / diagnosis

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  • (PMID = 19192639.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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77. Weber K, Damron TA, Frassica FJ, Sim FH: Malignant bone tumors. Instr Course Lect; 2008;57:673-88
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  • [Title] Malignant bone tumors.
  • Malignant bone tumors represent a small percentage of cancers nationwide and also are much less common than malignant soft-tissue tumors.
  • The most common primary malignant bone tumors, osteosarcoma and Ewing's sarcoma, occur in childhood.
  • Rare tumors such as chordoma and adamantinoma have anatomic predilections for the sacrum and tibia, respectively.
  • The primary symptom of a patient with a malignant bone tumor is pain, which often occurs at rest or at night.
  • Patients with a likely malignancy require thorough staging to determine the extent of disease and a well-planned biopsy for accurate diagnosis.
  • Knowledge of specific tumor characteristics and treatment options for osteosarcoma, Ewing's sarcoma, chondrosarcoma, malignant fibrous histiocytoma, chordoma, and adamantinoma is important.
  • Specific techniques are available for the resection of malignant bone tumors from the upper extremities, lower extremities, pelvis, and spine.
  • The care of patients with primary malignant bone tumors requires a multidisciplinary approach to treatment.

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  • (PMID = 18399615.001).
  • [ISSN] 0065-6895
  • [Journal-full-title] Instructional course lectures
  • [ISO-abbreviation] Instr Course Lect
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 42
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78. Niu CH, Li TJ: [Mutation and polymorphism of the ameloblastin gene in ameloblastomas]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2006 Nov;41(11):678-81
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  • [Title] [Mutation and polymorphism of the ameloblastin gene in ameloblastomas].
  • OBJECTIVE: To investigate the presence of mutation or polymorphism of ameloblastin (AMBN) gene in ameloblastomas.
  • METHODS: Genomic DNA was extracted from frozen tissues of 10 ameloblastomas and one malignant ameloblastoma.
  • Restriction fragment length polymorphism (RFLP) analysis was used to further determine the nature of the changes in AMBN detected in tumor samples in comparison to 100 control samples.
  • RESULTS: AMBN mutation was not identified in all 11 tumor samples.
  • CONCLUSIONS: AMBN gene mutation is not identified in the present group of ameloblastomas.
  • The frequently detected AMBN alterations in ameloblastomas are polymorphisms, which appear to be unrelated to the occurrence of ameloblastomas.
  • [MeSH-major] Ameloblastoma / genetics. Dental Enamel Proteins / genetics. Jaw Neoplasms / genetics. Polymorphism, Genetic

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  • (PMID = 17331365.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / AMBN protein, human; 0 / Dental Enamel Proteins
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79. Ozlugedik S, Ozcan M, Basturk O, Deren O, Kaptanoglu E, Adanali G, Unal A: Ameloblastic carcinoma arising from anterior skull base. Skull Base; 2005 Nov;15(4):269-72; discussion 273
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  • Ameloblastic carcinoma (AC) is an aggressive malignant epithelial odontogenic tumor.
  • It may appear de novo or originate from a pre-existing ameloblastoma or odontogenic cyst.

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  • (PMID = 16648889.001).
  • [ISSN] 1531-5010
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1380266
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80. Ram H, Mohammad S, Husain N, Gupta PN: Ameloblastic carcinoma. J Maxillofac Oral Surg; 2010 Dec;9(4):415-9
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  • Ameloblastic carcinoma (AC) is a rare aggressive malignant epithelial odontogenic tumor of the maxillofacial skeleton with a distinct predilection in the mandible.
  • It may appear de novo or originate from a pre-existing ameloblastoma or odontogenic cyst.
  • It exhibits cytological features of ameloblastoma and carcinoma.

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  • (PMID = 22190836.001).
  • [ISSN] 0974-942X
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3177477
  • [Keywords] NOTNLM ; Ameloblastic carcinoma / Ameloblastoma / Odontogenic tumor
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81. Kumamoto H, Ooya K: Immunohistochemical detection of retinoblastoma protein and E2 promoter-binding factor-1 in ameloblastomas. J Oral Pathol Med; 2006 Mar;35(3):183-9
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  • [Title] Immunohistochemical detection of retinoblastoma protein and E2 promoter-binding factor-1 in ameloblastomas.
  • BACKGROUND: To clarify the roles of cell cycle regulation in oncogenesis and cytodifferentiation of odontogenic tumors, expression of retinoblastoma protein (RB) and E2 promoter-binding factor-1 (E2F-1) was analyzed in ameloblastomas as well as in tooth germs.
  • METHODS: Tissue specimens of 10 tooth germs, 40 benign ameloblastomas, and five malignant ameloblastomas were examined immunohistochemically with the use of antibodies against RB, E2F-1, and phosphorylated RB.
  • RESULTS: Immunohistochemical reactivity for RB, E2F-1, phosphorylated RB, and Ki-67 was detected in the nuclei of odontogenic epithelial cells near the basement membrane in tooth germs and benign and malignant ameloblastomas.
  • The levels of immunoreactivity for RB, E2F-1, phosphorylated RB, and Ki-67 were slightly higher in benign and malignant ameloblastomas than in tooth germs.
  • Plexiform ameloblastomas showed significantly higher expression of RB than follicular ameloblastomas.
  • Ki-67 immunoreactivity was significantly higher in ameloblastic carcinomas than in metastasizing ameloblastomas.
  • CONCLUSION: Similar immunoreactivity for RB, E2F-1, phosphorylated RB, and Ki-67 in tooth germs and ameloblastomas indicated cellular expression of phosphorylated RB and active-free E2F-1 in both normal and neoplastic odontogenic tissues.
  • [MeSH-major] Ameloblastoma / chemistry. E2F1 Transcription Factor / analysis. Retinoblastoma Protein / analysis

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  • (PMID = 16454815.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / E2F1 Transcription Factor; 0 / Ki-67 Antigen; 0 / Retinoblastoma Protein
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82. Olgac V, Koseoglu BG, Aksakalli N: Odontogenic tumours in Istanbul: 527 cases. Br J Oral Maxillofac Surg; 2006 Oct;44(5):386-8
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  • Of these 527 tumours, 521 were benign and 6 were malignant.
  • The most common lesions were ameloblastomas (n=133) followed by odontomas (n=109), odontogenic myxomas (n=83) and others.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Ameloblastoma / epidemiology. Child. Child, Preschool. Female. Fibroma, Ossifying / epidemiology. Humans. Male. Middle Aged. Myxoma / epidemiology. Odontoma / epidemiology. Turkey / epidemiology

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  • (PMID = 16182417.001).
  • [ISSN] 0266-4356
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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83. Akhtar K, Khan N, Zaheer S, Sherwani R, Hasan A: Pindborg tumor in an adolescent. Oman Med J; 2010 Jan;25(1):47-8
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  • [Title] Pindborg tumor in an adolescent.
  • Calcifying epithelial odontogenic tumor (Pindborg tumor), is a rare benign odontogenic neoplasm representing about 0.4-3% of all odontogenic tumors.
  • This tumor more frequently affects adults in the age range of 20-60 years, with a peak incidence in the 5th decade of life.
  • Calcifying epithelial odontogenic tumour has a much lower recurrence rate than ameloblastoma and malignant transformation, and metastasis is rare.

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  • (PMID = 22125699.001).
  • [ISSN] 2070-5204
  • [Journal-full-title] Oman medical journal
  • [ISO-abbreviation] Oman Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Oman
  • [Other-IDs] NLM/ PMC3215391
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84. Kumamoto H, Ooya K: Immunohistochemical detection of uPA, uPAR, PAI-1, and maspin in ameloblastic tumors. J Oral Pathol Med; 2007 Sep;36(8):488-94
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  • METHODS: Tissue specimens of 10 tooth germs, 45 ameloblastomas, and 5 malignant ameloblastic tumors were examined immunohistochemically with the use of antibodies against uPA, uPAR, PAI-1, and maspin.
  • The levels of uPA and uPAR immunoreactivity in ameloblastic tumors were slightly higher than the levels in tooth germs, while PAI-1 reactivity in ameloblastomas tended to be lower than that in tooth germs.
  • The level of maspin immunoreactivity in ameloblastomas was significantly higher than that in tooth germs, and ameloblastic carcinoma showed decreased maspin reactivity.
  • CONCLUSION: Expression of uPA, uPAR, PAI-1, and maspin in tooth germs and ameloblastic tumors suggests that interactions among these molecules contribute to ECM degradation and cell migration during tooth development and tumor progression.
  • [MeSH-major] Ameloblastoma / pathology. Enzyme Precursors / analysis. Plasminogen Activator Inhibitor 1 / analysis. Receptors, Cell Surface / analysis. Serine Proteinase Inhibitors / analysis. Serpins / analysis. Urokinase-Type Plasminogen Activator / analysis

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  • (PMID = 17686008.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Enzyme Precursors; 0 / PLAUR protein, human; 0 / Plasminogen Activator Inhibitor 1; 0 / Receptors, Cell Surface; 0 / Receptors, Urokinase Plasminogen Activator; 0 / SERPIN-B5; 0 / Serine Proteinase Inhibitors; 0 / Serpins; EC 3.4.21.73 / Urokinase-Type Plasminogen Activator
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85. Kumamoto H, Ooya K: Immunohistochemical detection of platelet-derived endothelial cell growth factor/thymidine phosphorylase and angiopoietins in ameloblastic tumors. J Oral Pathol Med; 2006 Nov;35(10):606-12
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  • METHODS: Tissue specimens of 11 tooth germs, 44 ameloblastomas, and five malignant ameloblastic tumors were examined immunohistochemically with the use of antibodies against PD-ECGF/TP and angiopoietin-1 and -2.
  • RESULTS: Immunohistochemical reactivity for PD-ECGF/TP was detected in mesenchymal cells in tooth germs and stromal cells in ameloblastic tumors, and the level of immunoreactivity for PD-ECGF/TP was significantly higher in ameloblastomas than in tooth germs.
  • Granular cell ameloblastomas showed PD-ECGF/TP reactivity in granular neoplastic cells as well as in stromal cells.
  • Immunoreactivity for angiopoietin-1 and -2 was detected predominantly in odontogenic epithelial cells near the basement membrane in tooth germs and in benign and malignant ameloblastic tumors.
  • Malignant ameloblastic tumors had decreased angiopoietin-1 reactivity and ameloblastic carcinomas had increased angiopoietin-2 reactivity as compared with the respective levels in tooth germs and ameloblastomas.
  • Immunohistochemical reactivity for angiopoietin-2 was slightly higher in follicular ameloblastomas than in plexiform ameloblastomas.
  • CONCLUSION: Expression of PD-ECGF/TP and angiopoietin-1 and -2 in tooth germs and ameloblastic tumors suggests that these angiogenic factors participate in tooth development and odontogenic tumor progression by regulating angiogenesis.
  • Altered expression of PD-ECGF/TP and angiopoietins in ameloblastic tumors may be involved in oncogenesis, malignant potential, and tumor cell differentiation.
  • [MeSH-major] Ameloblastoma / chemistry. Angiopoietin-1 / analysis. Angiopoietin-2 / analysis. Jaw Neoplasms / chemistry. Thymidine Phosphorylase / analysis

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  • (PMID = 17032393.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / ANGPT1 protein, human; 0 / Angiopoietin-1; 0 / Angiopoietin-2; EC 2.4.2.4 / Thymidine Phosphorylase
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86. Chen WL, Ouyang KX, Li HG, Huang ZQ, Li JS, Wang JG: Expression of inducible nitric oxide synthase and vascular endothelial growth factor in ameloblastoma. J Craniofac Surg; 2009 Jan;20(1):171-5; discussion 176-7
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  • [Title] Expression of inducible nitric oxide synthase and vascular endothelial growth factor in ameloblastoma.
  • The purposes of this study were to determine the correlation between the expression of inducible nitric oxide synthase (iNOS) and vascular endothelial growth factor (VEGF) in ameloblastoma and to examine the relationships of this expression to angiogenesis and the clinical and biological behaviors of the tumor.
  • Immunohistochemical staining with streptavidin peroxidase was used to analyze iNOS and VEGF expression, and CD34 was used to evaluate microvascular density (MVD) in 35 ameloblastomas (24 primary tumors and 11 recurrences) and 5 malignant ameloblastomas.
  • On relational analysis, positive and VEGF expression and MVD counts increased in this order: OKCs, primary ameloblastoma, recurrent ameloblastoma, and malignant ameloblastoma.
  • Differences between the ameloblastomas and OKCs were significant (P < 0.05).
  • Among ameloblastomas, MVD counts increased with increasing expression of iNOS and VEGF (P < 0.05), and iNOS expression and VEGF expression were positively correlated (r = 0.66, P < 0.05).
  • Inducible nitric oxide synthase expression and VEGF expression may be closely related to the angiogenesis and invasive biological behavior of ameloblastomas.
  • [MeSH-major] Ameloblastoma / pathology. Neovascularization, Pathologic / pathology. Nitric Oxide Synthase Type II / analysis. Vascular Endothelial Growth Factor A / analysis

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  • (PMID = 19165019.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; EC 1.14.13.39 / NOS2 protein, human; EC 1.14.13.39 / Nitric Oxide Synthase Type II
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87. Zhang B, Zhang J, Xu ZY, Xie HL: Expression of RECK and matrix metalloproteinase-2 in ameloblastoma. BMC Cancer; 2009;9:427
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  • [Title] Expression of RECK and matrix metalloproteinase-2 in ameloblastoma.
  • BACKGROUND: Ameloblastoma is a frequent odontogenic benign tumor characterized by local invasiveness, high risk of recurrence and occasional metastasis and malignant transformation.
  • Matrix metalloproteinase-2 (MMP-2) promotes tumor invasion and progression by destroying the extracellular matrix (ECM) and basement membrane.
  • The aim of this study was to characterize the relationship between RECK and MMP-2 expression and the clinical manifestation of ameloblastoma.
  • METHODS: Immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR) were employed to detect the protein and mRNA expression of RECK and MMP-2 in keratocystic odontogenic tumor (KCOT), ameloblastoma and ameloblastic carcinoma.
  • RESULTS: RECK protein expression was significantly reduced in KCOT (87.5%), ameloblastoma (56.5%) and ameloblastic carcinoma (0%) (P < 0.01), and was significantly lower in recurrent ameloblastoma compared with primary ameloblastoma (P < 0.01), but did not differ by histological type of ameloblastoma.
  • MMP-2 protein expression was significantly higher in ameloblastoma and ameloblastic carcinoma compared with KCOT (P < 0.01).
  • RECK mRNA expression was significantly lower in ameloblastoma than in KCOT (P < 0.01), lower in recurrent ameloblastoma than in primary ameloblastoma, and was negative in ameloblastic carcinoma.
  • MMP-2 mRNA expression was significantly higher in ameloblastoma compared with KCOT (P < 0.01), but was no different in recurrent ameloblastoma versus primary ameloblastoma.
  • RECK protein expression was negatively associated with MMP-2 protein expression in ameloblastoma (r = -0.431, P < 0.01).
  • CONCLUSION: Low or no RECK expression and increased MMP-2 expression may be associated with negative clinical findings in ameloblastoma.
  • RECK may participate in the invasion, recurrence and malignant transformation of ameloblastoma by regulating MMP-2 at the post-transcriptional level.
  • [MeSH-major] Ameloblastoma / metabolism. Jaw Neoplasms / metabolism. Matrix Metalloproteinase 2 / biosynthesis. Membrane Glycoproteins / biosynthesis

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  • (PMID = 19995435.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / GPI-Linked Proteins; 0 / Membrane Glycoproteins; 0 / RECK protein, human; 0 / RNA, Messenger; EC 3.4.24.24 / Matrix Metalloproteinase 2
  • [Other-IDs] NLM/ PMC2794878
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88. Karakida K, Aoki T, Sakamoto H, Takahashi M, Akamatsu T, Ogura G, Sekido Y, Ota Y: Ameloblastic carcinoma, secondary type: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Dec;110(6):e33-7
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  • Malignant variants of ameloblastoma include metastasizing ameloblastoma, which microscopically appears benign but has metastasized and ameloblastic carcinoma that exhibits malignant histopathologic features.
  • Ameloblastic carcinoma is classified into 2 types: a primary odontogenic malignancy and a secondary type resulting from malignant transformation of ameloblastoma.
  • Most secondary ameloblastic carcinomas result from malignant transformation of a primary lesion after repeated postsurgical recurrences.
  • Therefore it is rare to find an untreated secondary type presenting with histologic features of malignant transformation from an earlier benign lesion.
  • We experienced a rare case of ameloblastic carcinoma, secondary type which might arise in an untreated ameloblastoma.
  • The mechanism by which a preexisting benign ameloblastoma goes through a malignant transformation is also described.
  • [MeSH-major] Ameloblastoma / pathology. Cell Transformation, Neoplastic / pathology. Mandibular Neoplasms / pathology. Odontogenic Tumors / pathology
  • [MeSH-minor] Adult. Biopsy. Humans. Ki-67 Antigen / analysis. Male. Radiography, Panoramic. Tomography, X-Ray Computed. Tumor Suppressor Protein p53 / analysis

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  • [Copyright] Crown Copyright © 2010. Published by Mosby, Inc. All rights reserved.
  • (PMID = 21112523.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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89. Mavrogenis AF, Galanakos S, Savvidou OD, Papagelopoulos PJ: Adamantinoma of the tibia mimicking a benign cystic lesion: a case report. Clin Podiatr Med Surg; 2010 Jan;27(1):157-65
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  • [Title] Adamantinoma of the tibia mimicking a benign cystic lesion: a case report.
  • Adamantinoma of the long bones is a rare primary malignant bone tumor accounting for less than 1% of all primary malignant bone tumors.
  • In this article, the authors present a case report of a patient with a distal tibia adamantinoma mimicking a benign cystic lesion.
  • [MeSH-major] Adamantinoma / diagnosis. Bone Cysts / diagnosis. Bone Neoplasms / diagnosis. Tibia

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  • (PMID = 19963177.001).
  • [ISSN] 1558-2302
  • [Journal-full-title] Clinics in podiatric medicine and surgery
  • [ISO-abbreviation] Clin Podiatr Med Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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90. Bello IO, Soini Y, Slootweg PJ, Salo T: Claudins 1, 4, 5, 7 and occludin in ameloblastomas and developing human teeth. J Oral Pathol Med; 2007 Jan;36(1):48-54
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  • [Title] Claudins 1, 4, 5, 7 and occludin in ameloblastomas and developing human teeth.
  • BACKGROUND: To analyze the distribution pattern of claudins 1, 4, 5, 7 and occludin in benign and malignant ameloblastomas and developing human teeth.
  • METHODS: Paraffin-embedded tissue specimens of 25 benign and four malignant ameloblastomas and two developing human teeth were examined immunohistochemically using antibodies against claudins 1, 4, 5, 7 and occludin.
  • RESULTS: In ameloblastomas strongest expression was seen for claudins 1 and 7 while claudin 4 was expressed less frequently.
  • There were no evident differences in the expression of claudins or occludin neither between different histologic subtypes of ameloblastomas nor between benign or malignant cases.
  • The strongest expression for claudins was present in the central stellatum reticulum-like cells surrounding the microcysts and in the areas with squamous differentiation of the ameloblastomas.
  • Claudin 5 was preferentially expressed only in vessels, and occludin staining ranged from negative to weak in ameloblastomas and teeth germs.
  • CONCLUSION: There were no clear differences in the expression levels between benign and malignant ameloblastic tumors.
  • [MeSH-major] Ameloblastoma / pathology. Membrane Proteins / analysis. Odontogenesis / physiology. Tight Junctions / pathology. Tooth Germ / pathology

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  • (PMID = 17181742.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / CLDN1 protein, human; 0 / CLDN4 protein, human; 0 / CLDN5 protein, human; 0 / CLDN7 protein, human; 0 / Claudin-1; 0 / Claudin-4; 0 / Claudin-5; 0 / Claudins; 0 / Membrane Proteins; 0 / OCLN protein, human; 0 / Occludin
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91. A J, Kc BR, Basnet SB, Panth R, Shrestha RL, Chand P, Thapa BB: Adamantinoma of tibial shaft. JNMA J Nepal Med Assoc; 2009 Oct-Dec;48(176):331-4
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  • [Title] Adamantinoma of tibial shaft.
  • Adamantinoma is an extremely rare primary bony neoplasm.
  • Because of its malignant nature, accurate and early diagnosis is very important.
  • On the other hand adamantinoma mimics many benign conditions, so it is doubly important to establish correct tissue diagnosis to avoid radical surgery with morbidities.
  • Because of its rarity, diagnosing adamantinoma still remains difficult, even if when it occurs in classical sites.
  • We report a case of adamantinoma of tibial shaft diaphysis in a 23 year male.
  • In this case, because of classic clinic-radiological features, we were suspecting adamantinoma from very beginning but final diagnosis was delayed for nine months.
  • [MeSH-major] Adamantinoma / diagnosis. Bone Neoplasms / diagnosis. Tibia

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  • (PMID = 21105562.001).
  • [ISSN] 0028-2715
  • [Journal-full-title] JNMA; journal of the Nepal Medical Association
  • [ISO-abbreviation] JNMA J Nepal Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nepal
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92. Desai SS, Jambhekar N, Agarwal M, Puri A, Merchant N: Adamantinoma of tibia: a study of 12 cases. J Surg Oncol; 2006 Apr 1;93(5):429-33
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  • [Title] Adamantinoma of tibia: a study of 12 cases.
  • BACKGROUND: Adamantinoma is a rare tumor of long bones that can be mistaken for a carcinoma, and numerous other lesions such as myoepithelial tumor, malignant mixed tumor of bone, fibrous dysplasia/osteofibrous dysplasia, and vascular tumors.
  • Radiologically the tumor presented as a lytic, eccentric, intracortical lesion in the tibia.
  • DISCUSSION: In this article, an attempt is made to study the morphology, biology, and the differential diagnoses of adamantinoma of long bones.
  • [MeSH-major] Adamantinoma. Bone Neoplasms. Tibia

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16550582.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 30
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93. Powers J, Zhao Y, Lin S, McCabe ER: The expression of nr0b1, the earliest gene in zebrafish tooth development, is a marker for human tooth and ameloblastoma formation. Dev Genes Evol; 2009 Aug;219(8):419-25
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  • [Title] The expression of nr0b1, the earliest gene in zebrafish tooth development, is a marker for human tooth and ameloblastoma formation.
  • Based on the zebrafish observations, we demonstrated novel DAX1 expression in normal human dental, benign ameloblastoma, and malignant ameloblastoma tissues.
  • The association of NR0B1 and its protein product DAX1 with primary tooth development and ameloblastoma tumorigenesis is an association not previously described.
  • [MeSH-minor] Ameloblastoma / genetics. Animals. Embryo, Nonmammalian / metabolism. Gene Expression Regulation, Developmental. Homeodomain Proteins. Humans. Tooth / embryology

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  • (PMID = 19826837.001).
  • [ISSN] 1432-041X
  • [Journal-full-title] Development genes and evolution
  • [ISO-abbreviation] Dev. Genes Evol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DAX-1 Orphan Nuclear Receptor; 0 / Homeodomain Proteins; 0 / NR0B1 protein, human; 0 / Zebrafish Proteins
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94. Jing W, Xuan M, Lin Y, Wu L, Liu L, Zheng X, Tang W, Qiao J, Tian W: Odontogenic tumours: a retrospective study of 1642 cases in a Chinese population. Int J Oral Maxillofac Surg; 2007 Jan;36(1):20-5
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  • Of these tumours 1592 (97.0%) were benign and 50 (3.0%) were malignant.
  • Ameloblastoma (40.3%) was the most frequent type, followed by keratocystic odontogenic tumour (35.8%), odontoma (4.7%) and odontogenic myxoma (4.6%).
  • Ameloblastoma and keratocystic odontogenic tumours, important indications of extensive surgical procedures, are not considered rare in this Chinese population, whereas odontoma is uncommon.
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Aged, 80 and over. Ameloblastoma / epidemiology. Ameloblastoma / pathology. Child. Child, Preschool. China / epidemiology. Female. Humans. Male. Middle Aged. Retrospective Studies. Sex Ratio

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  • (PMID = 17156974.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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95. Kumamoto H, Ooya K: Detection of mitochondria-mediated apoptosis signaling molecules in ameloblastomas. J Oral Pathol Med; 2005 Oct;34(9):565-72
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  • [Title] Detection of mitochondria-mediated apoptosis signaling molecules in ameloblastomas.
  • BACKGROUND: To investigate the roles of the apoptosis signaling pathway mediated by mitochondria in oncogenesis and cytodifferentiation of odontogenic tumors, expression of pathway signaling molecules was analyzed in ameloblastomas as well as in tooth germs.
  • METHODS: Tissue specimens of 12 tooth germs, 41 benign ameloblastomas, and five malignant ameloblastomas were examined by reverse transcriptase polymerase chain reaction (RT-PCR) and immunohistochemistry to determine the expression of cytochrome c, apoptotic protease-activating factor-1 (APAF-1), caspase-9, and apoptosis-inducing factor (AIF).
  • Immunoreactivity for cytochrome c in tooth germs was slightly weaker than that in benign and malignant ameloblastomas.
  • Keratinizing cells in acanthomatous ameloblastomas and granular cells in granular cell ameloblastomas showed a decrease or loss of immunoreactivity for these mitochondria-mediated apoptosis signaling molecules.
  • CONCLUSION: Expression of cytochrome c, APAF-1, caspase-9, and AIF in tooth germs and ameloblastomas suggests that the mitochondria-mediated apoptotic pathway has a role in apoptotic cell death of normal and neoplastic odontogenic epithelium.
  • Expression of these mitochondrial apoptosis signaling molecules might be involved in oncogenesis, cytodifferentiation, and malignant transformation of odontogenic epithelium.
  • [MeSH-major] Ameloblastoma / pathology. Apoptosis / physiology. Intracellular Signaling Peptides and Proteins / analysis. Mitochondria / physiology. Signal Transduction / physiology

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  • (PMID = 16138896.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / AIFM1 protein, human; 0 / APAF1 protein, human; 0 / Apoptosis Inducing Factor; 0 / Apoptotic Protease-Activating Factor 1; 0 / Flavoproteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / Membrane Proteins; 0 / Proteins; 9007-43-6 / Cytochromes c; EC 3.4.22.- / CASP9 protein, human; EC 3.4.22.- / Caspase 9; EC 3.4.22.- / Caspases
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96. Llombart-Bosch A, Machado I, Navarro S, Bertoni F, Bacchini P, Alberghini M, Karzeladze A, Savelov N, Petrov S, Alvarado-Cabrero I, Mihaila D, Terrier P, Lopez-Guerrero JA, Picci P: Histological heterogeneity of Ewing's sarcoma/PNET: an immunohistochemical analysis of 415 genetically confirmed cases with clinical support. Virchows Arch; 2009 Nov;455(5):397-411
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  • Ewing's sarcoma (ES)/peripheral neuroectodermal tumor (PNET) are malignant neoplasms affecting children and young adults.
  • This study confirms the structural heterogeneity of ES/PNET, distinguishing three major subtypes: conventional ES (280 cases); PNET (53 cases); and atypical ES/PNET (80), including large cells, vascular-like patterns, spindle pattern, and adamantinoma-like configuration.
  • Hence, the immunohistochemical analysis confirmed the diagnostic value of all four antibodies, which together cover more than 99% of the tumors, independently of the histological variety.
  • [MeSH-major] Antibodies. Biomarkers, Tumor / analysis. Bone Neoplasms / pathology. Neuroectodermal Tumors, Primitive, Peripheral / pathology. Sarcoma, Ewing / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD / biosynthesis. Antigens, CD57 / biosynthesis. Antigens, CD99. Caveolin 1 / biosynthesis. Cell Adhesion Molecules / biosynthesis. Child. Child, Preschool. Disease Progression. Female. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Infant. Kaplan-Meier Estimate. Male. Middle Aged. Prognosis. Proto-Oncogene Protein c-fli-1 / biosynthesis. Young Adult

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  • (PMID = 19841938.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies; 0 / Antigens, CD; 0 / Antigens, CD57; 0 / Antigens, CD99; 0 / Biomarkers, Tumor; 0 / CAV1 protein, human; 0 / CD99 protein, human; 0 / Caveolin 1; 0 / Cell Adhesion Molecules; 0 / FLI1 protein, human; 0 / Proto-Oncogene Protein c-fli-1
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97. Kumamoto H, Ooya K: Immunohistochemical detection of MT1-MMP, RECK, and EMMPRIN in ameloblastic tumors. J Oral Pathol Med; 2006 Jul;35(6):345-51
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  • METHODS: Tissue specimens of 11 tooth germs, 40 ameloblastomas, and five malignant ameloblastic tumors were examined immunohistochemically with the use of antibodies against MT1-MMP, RECK, and EMMPRIN.
  • RESULTS: Immunohistochemical reactivity for MT1-MMP, RECK and EMMPRIN was detected predominantly in odontogenic epithelial cells near the basement membrane in tooth germs and benign and malignant ameloblastic tumors.
  • The level of immunoreactivity for MT1-MMP was slightly higher in benign and malignant ameloblastic tumors than in tooth germs.
  • RECK expression was lower in ameloblastomas than in tooth germs.
  • Follicular ameloblastomas showed significantly lower expression of RECK than plexiform ameloblastomas, and immunoreactivity for RECK in acanthomatous ameloblastomas was slightly lower than that in other cellular variants.
  • CONCLUSION: Expression of MT1-MMP, RECK and EMMPRIN in tooth germs and ameloblastic tumors suggests that these normal and neoplastic epithelial components control MMP-dependent extracellular matrix (ECM) degradation during tooth development and tumor progression via epithelial-mesenchymal interactions.
  • [MeSH-major] Ameloblastoma / chemistry. Antigens, CD147 / analysis. Jaw Neoplasms / chemistry. Matrix Metalloproteinases / analysis. Membrane Glycoproteins / analysis. Tooth Germ / chemistry

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  • (PMID = 16762015.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / GPI-Linked Proteins; 0 / Membrane Glycoproteins; 0 / RECK protein, human; 136894-56-9 / Antigens, CD147; EC 3.4.24.- / Matrix Metalloproteinases; EC 3.4.24.- / Matrix Metalloproteinases, Membrane-Associated
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98. Zhang ZH, Lu YC, Meng QF, Wu PH: [CT diagnosis of various subtypes of ameloblastoma in the maxillomandibular region]. Ai Zheng; 2006 Oct;25(10):1266-70
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  • [Title] [CT diagnosis of various subtypes of ameloblastoma in the maxillomandibular region].
  • BACKGROUND & OBJECTIVE: Based on biological behavior and histopathologic characteristics, ameloblastomas in the maxillomandibular region can be divided into several subtypes with different prognosis.
  • This study was to explore the clinical and CT imaging features of solid or multicystic ameloblastoma (SMA), unicystic ameloblastoma (UA), and malignant ameloblastoma (MA), and thus to improve the CT diagnostic accuracy for these diseases.
  • METHODS: Clinical and CT features of 25 histologically proven ameloblastomas in the maxillomandibular region, including 14 SMAs, 6 UAs, and 5 MAs were analyzed retrospectively.
  • Combined analysis of CT images and clinical data is helpful in differentiating these 3 subtypes of ameloblastoma.
  • [MeSH-major] Ameloblastoma / radiography. Mandibular Neoplasms / radiography. Maxillary Neoplasms / radiography. Tomography, X-Ray Computed / methods

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  • (PMID = 17059773.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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99. Tao Q, Lv B, Qiao B, Zheng CQ, Chen ZF: Immortalization of ameloblastoma cells via reactivation of telomerase function: Phenotypic and molecular characteristics. Oral Oncol; 2009 Dec;45(12):e239-44
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  • [Title] Immortalization of ameloblastoma cells via reactivation of telomerase function: Phenotypic and molecular characteristics.
  • Ameloblastoma (AM) is recognized as a benign tumour but locally invasive with a high risk of recurrence.
  • In vitro model systems for studying AM are limited due to the fact that AM cells grow poorly and begin to senesce early.
  • Japanese researchers have reported the construction of an AM cell line, AM-1, by exposing cells to human papillomavirus 16 (HPV16) but retaining the potential of transformation.
  • In this study, we used a retroviral infection method to over-express the human telomerase reverse transcriptase (hTERT) gene to acquire immortality of hTERT(+)-AM cells.
  • Also, there was no evidence indicating that the hTERT(+)-AM cells underwent malignant transformation by the nude mouse tumorigenicity assay.
  • Taken together, this hTERT-immortalized cell line may be a potentially valuable and reliable cell model for further study of the invasive properties of AM in vitro.
  • [MeSH-major] Ameloblastoma / pathology. Jaw Neoplasms / pathology. Neoplasm Proteins / metabolism. Telomerase / metabolism
  • [MeSH-minor] Blotting, Western. Cell Culture Techniques. Cell Line, Transformed / virology. Cell Line, Tumor. Cell Proliferation. Cell Transformation, Viral. Enzyme Activation. Epigenesis, Genetic. Human papillomavirus 16. Humans. Male. Middle Aged. Reverse Transcriptase Polymerase Chain Reaction. Transfection / methods

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  • (PMID = 19833545.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; EC 2.7.7.49 / TERT protein, human; EC 2.7.7.49 / Telomerase
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100. Nguyen BD: Malignant ameloblastoma with thoracic vertebral metastasis: PET/CT and MR imaging. Clin Nucl Med; 2005 Jun;30(6):450-2
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  • [Title] Malignant ameloblastoma with thoracic vertebral metastasis: PET/CT and MR imaging.
  • [MeSH-major] Ameloblastoma / diagnosis. Ameloblastoma / secondary. Fluorodeoxyglucose F18. Mandibular Neoplasms / diagnosis. Mandibular Neoplasms / secondary. Spinal Neoplasms / diagnosis. Spinal Neoplasms / secondary. Thoracic Vertebrae

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  • (PMID = 15891309.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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