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86. Katsnel'son BA, Kuz'min SV, Gurvich VB: [The concept of acceptable risk is the key debatable issue of the assessment and management of a risk to the population's health]. Gig Sanit; 2007 May-Jun;(3):76-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The concept of acceptable risk is the key debatable issue of the assessment and management of a risk to the population's health].
  • They criticize the sociostatistical and socioeconomic concepts of risk acceptability as both amoral and impracticable and propose an approach based on the use of the Russian standards of permissible exposure levels (maximum permissible concentrations in particular) and on the exposure-response relationships established by epidemiological studies for the computation of responses (i.e. risk levels) corresponding to the permissible exposures.
  • In some cases that such standards of an acceptable risk are too strict in existing technological or economic practice may be introduced in a stepwise fashion, but the risks that exceed the acceptable level should be compensated for.

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  • (PMID = 17658052.001).
  • [ISSN] 0016-9900
  • [Journal-full-title] Gigiena i sanitariia
  • [ISO-abbreviation] Gig Sanit
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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87. Leto TL, Lavigne MC, Homoyounpour N, Lekstrom K, Linton G, Malech HL, de Mendez I: The K-562 cell model for analysis of neutrophil NADPH oxidase function. Methods Mol Biol; 2007;412:365-83
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  • Polymorphonuclear neutrophils (PMN) have a remarkable capacity for generation of large amounts of reactive oxygen species in response to a variety of infectious or inflammatory stimuli, a process known as the respiratory burst that involves activation of a multicomponent NADPH oxidase.
  • We have explored a variety of methods for introduction of components of the phagocytic oxidase (phox system) into the promyelocytic erythroleukemia cell line, K-562.
  • These versatile lines can be used to examine effects of genetic polymorphisms or mutations in phox components associated with chronic granulomatous disease, to serve as a system for testing gene therapy vectors designed to correct the defective oxidase, to study cross-functioning with recently described phox component homologs, or to explore signaling components involved in regulation of the respiratory burst.

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  • (PMID = 18453124.001).
  • [ISSN] 1064-3745
  • [Journal-full-title] Methods in molecular biology (Clifton, N.J.)
  • [ISO-abbreviation] Methods Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.6.3.1 / NADPH Oxidase
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88. Santiago-Doménech N, Jiménez-Bemúdez S, Matas AJ, Rose JK, Muñoz-Blanco J, Mercado JA, Quesada MA: Antisense inhibition of a pectate lyase gene supports a role for pectin depolymerization in strawberry fruit softening. J Exp Bot; 2008;59(10):2769-79
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  • [Title] Antisense inhibition of a pectate lyase gene supports a role for pectin depolymerization in strawberry fruit softening.
  • It has been reported previously that inhibiting the expression of pectate lyase genes by antisense technology in strawberry (Fragaria x ananassa Duch.) fruit resulted in prolonged fruit firmness.
  • In this present study, three independent transgenic lines were identified exhibiting a greater than 90% reduction in pectate lyase transcript abundance.
  • These results indicate that pectate lyase plays an important degradative role in the primary wall and middle lamella in ripening strawberry fruit, and should be included in synergistic models of cell wall disassembly.

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  • (PMID = 18522930.001).
  • [ISSN] 1460-2431
  • [Journal-full-title] Journal of experimental botany
  • [ISO-abbreviation] J. Exp. Bot.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Pectins; 0 / Plant Proteins; 9000-69-5 / pectin; EC 4.2.2.- / Polysaccharide-Lyases; EC 4.2.2.2 / pectate lyase
  • [Other-IDs] NLM/ PMC2486476
  • [Keywords] NOTNLM ; Cell wall / Fragaria / fruit ripening / pectate lyase / pectinases / strawberry
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89. Wang Y, Fiskus W, Chong DG, Buckley KM, Natarajan K, Rao R, Joshi A, Balusu R, Koul S, Chen J, Savoie A, Ustun C, Jillella AP, Atadja P, Levine RL, Bhalla KN: Cotreatment with panobinostat and JAK2 inhibitor TG101209 attenuates JAK2V617F levels and signaling and exerts synergistic cytotoxic effects against human myeloproliferative neoplastic cells. Blood; 2009 Dec 3;114(24):5024-33
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  • [Title] Cotreatment with panobinostat and JAK2 inhibitor TG101209 attenuates JAK2V617F levels and signaling and exerts synergistic cytotoxic effects against human myeloproliferative neoplastic cells.
  • PS also induced apoptosis of the cultured JAK2V617F-expressing human erythroleukemia HEL92.1.7 and Ba/F3-JAK2V617F cells.

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  • (PMID = 19828702.001).
  • [ISSN] 1528-0020
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA116629; United States / NCI NIH HHS / CA / R01 CA123207
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; 0 / Hydroxamic Acids; 0 / Indoles; 0 / Pyrimidines; 0 / Sulfonamides; 0 / TG101209; 9647FM7Y3Z / panobinostat; EC 2.7.10.2 / JAK2 protein, human; EC 2.7.10.2 / Janus Kinase 2
  • [Other-IDs] NLM/ PMC2788976
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90. Ambrose EC, Kornbluth J: Downregulation of uridine-cytidine kinase like-1 decreases proliferation and enhances tumor susceptibility to lysis by apoptotic agents and natural killer cells. Apoptosis; 2009 Oct;14(10):1227-36
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Here we use RNA interference to downregulate UCKL-1 expression in K562 erythroleukemia cells.
  • [MeSH-minor] Caspase 3 / metabolism. Caspase 7 / metabolism. Cell Cycle / drug effects. Cell Proliferation / drug effects. Etoposide / pharmacology. Gene Expression Regulation, Neoplastic / drug effects. Gene Silencing / drug effects. Green Fluorescent Proteins / metabolism. Humans. K562 Cells. RNA, Messenger / genetics. RNA, Messenger / metabolism. RNA, Small Interfering / metabolism. Staurosporine / pharmacology. Time Factors

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  • (PMID = 19653100.001).
  • [ISSN] 1573-675X
  • [Journal-full-title] Apoptosis : an international journal on programmed cell death
  • [ISO-abbreviation] Apoptosis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / RNA, Small Interfering; 147336-22-9 / Green Fluorescent Proteins; 6PLQ3CP4P3 / Etoposide; EC 2.7.1.48 / UCKL-1 protein, human; EC 2.7.1.48 / Uridine Kinase; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspase 7; H88EPA0A3N / Staurosporine
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91. Chen H, Ding XY, Gao Y, Liu XL, Gao JE, Sun QH: [Recombinant human VEGF-D induces the angiogenesis of the chick embryo chorioallantoic membrane]. Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2007 Apr;15(2):364-8
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  • The soluble GST-VEGF-D fusion protein could interact with VEGFR-3/Fc and was able to stimulate the proliferation of human erythroleukemia cell line (HEL) cells.

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  • (PMID = 17493348.001).
  • [ISSN] 1009-2137
  • [Journal-full-title] Zhongguo shi yan xue ye xue za zhi
  • [ISO-abbreviation] Zhongguo Shi Yan Xue Ye Xue Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Recombinant Proteins; 0 / Vascular Endothelial Growth Factor D
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92. Saar K, Lindgren M, Hansen M, Eiríksdóttir E, Jiang Y, Rosenthal-Aizman K, Sassian M, Langel U: Cell-penetrating peptides: a comparative membrane toxicity study. Anal Biochem; 2005 Oct 1;345(1):55-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Therefore, we investigated membrane toxicity of five peptides with well-documented cell-penetrating properties, pAntp(43-58), pTAT(48-60), pVEC(615-632), model amphipathic peptide (MAP), and transportan 10, on two human cancer cell lines, K562 (erythroleukemia) and MDA-MB-231 (breast cancer), as well as on immortalized aortic endothelial cells.
  • MAP and transportan 10 caused significant leakage; in K562 and MDA-MB-231 cells, 40% of total lactate dehydrogenase leaked out during 10 min exposure to 10 microM of transportan 10 and MAP, accompanied by a significant increase in bis-oxonol fluorescence.

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  • (PMID = 16137634.001).
  • [ISSN] 0003-2697
  • [Journal-full-title] Analytical biochemistry
  • [ISO-abbreviation] Anal. Biochem.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Drug Carriers; 0 / Peptides
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93. Shaked Y, Emmenegger U, Francia G, Chen L, Lee CR, Man S, Paraghamian A, Ben-David Y, Kerbel RS: Low-dose metronomic combined with intermittent bolus-dose cyclophosphamide is an effective long-term chemotherapy treatment strategy. Cancer Res; 2005 Aug 15;65(16):7045-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • However, whereas surprisingly durable and potent tumor responses have been observed in a number of preclinical tumor models, relapses usually eventually occur using this type of treatment strategy.
  • Here, we show that repeated administration of bolus doses (BDs) of cyclophosphamide every 3 or 6 weeks, combined with a daily oral low-dose metronomic (LDM) regimen (20 mg/kg/d cyclophosphamide), improves efficacy and significantly delays progression of transplanted PC-3 human prostate cancer xenografts, syngeneic transplanted EMT-6 breast tumors, and "spontaneous" murine erythroleukemia.
  • Efficacy was superior whereas toxicity was mild and comparable to the LDM regimen, the latter assessed by body weight, neutrophil, lymphocyte, and total white blood counts.
  • [MeSH-major] Antineoplastic Agents, Alkylating / administration & dosage. Cyclophosphamide / administration & dosage. Leukemia, Erythroblastic, Acute / drug therapy. Mammary Neoplasms, Experimental / drug therapy. Prostatic Neoplasms / drug therapy

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  • (PMID = 16103050.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-41233
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 8N3DW7272P / Cyclophosphamide
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9
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4. Eilertsen GØ, Nossent JC: Erythroleukaemia complicating ANA-negative systemic lupus erythematosus. Scand J Rheumatol; 2007 Nov-Dec;36(6):478-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Erythroleukaemia complicating ANA-negative systemic lupus erythematosus.
  • [MeSH-major] Antibodies, Antinuclear / blood. Leukemia, Erythroblastic, Acute / etiology. Lupus Erythematosus, Systemic / complications

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  • (PMID = 18092272.001).
  • [ISSN] 0300-9742
  • [Journal-full-title] Scandinavian journal of rheumatology
  • [ISO-abbreviation] Scand. J. Rheumatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Antibodies, Antinuclear
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95. Parry TE: On the pathogenesis of erythroleukaemia (H0493). Leuk Res; 2005 Feb;29(2):119-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] On the pathogenesis of erythroleukaemia (H0493).
  • In erythroleukaemia megaloblastic changes can co-exist with leukaemic changes in the marrow.
  • The cause of the disease must therefore be such as can cause megaloblastosis and at the same time be mutagenic.
  • Failure of the thymidylate synthelase reaction, the commonest cause of megaloblastic anaemia, can be eliminated in erythroleukaemia because (a) the dU suppression test is normal in the disease and (b) failure of the thymidylate synthelase reaction is not mutagenic.
  • The deamination of both cytosine and adenine is mutagenic but the deamination of cytosine alone is apparent and the nucleotide of cytosine is the prime mutagenic nucleotide in leukaemia and cancer.
  • Megaloblastic changes can result from an inadequate supply of any one of the four nucleotides that enter into the composition of DNA and it is suggested that an inadequate supply of the mutagenic nucleotide of cytosine, possibly through impaired synthesis, could cause both the megaloblastic and leukaemic changes in erythroleukaemia.
  • [MeSH-major] Leukemia, Erythroblastic, Acute / etiology

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  • (PMID = 15607356.001).
  • [ISSN] 0145-2126
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Nucleotides; 9007-49-2 / DNA; EC 2.1.1.45 / Thymidylate Synthase
  • [Number-of-references] 22
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96. Mohan SV, Mouli PC: Assessment of aerosol (PM10) and trace elemental interactions by Taguchi experimental design approach. Ecotoxicol Environ Saf; 2008 Mar;69(3):562-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Seven toxic trace metals (Cu, Cd, As, Pb, Cr, Co and Ni) along with aerosol mass (PM(10)) at three different concentration levels were considered for this study.
  • The annual mean concentrations of PM(10) and its trace components observed at Tirupati, southern peninsular India, and 50% lower and 50% higher values to the permissible exposure limit (PEL) of each factor in air were considered for level 1, level 2, and level 3 respectively.
  • Interactions between the factors have been estimated by orthogonal array design of experiments with eighteen sets of experimental trial (L18) and varied combinations of factor levels.

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  • (PMID = 17490743.001).
  • [ISSN] 0147-6513
  • [Journal-full-title] Ecotoxicology and environmental safety
  • [ISO-abbreviation] Ecotoxicol. Environ. Saf.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aerosols; 0 / Trace Elements; 0R0008Q3JB / Chromium; 2P299V784P / Lead; 3G0H8C9362 / Cobalt; 789U1901C5 / Copper; 7OV03QG267 / Nickel; N712M78A8G / Arsenic
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97. Bavelloni A, Faenza I, Cioffi G, Piazzi M, Parisi D, Matic I, Maraldi NM, Cocco L: Proteomic-based analysis of nuclear signaling: PLCbeta1 affects the expression of the splicing factor SRp20 in Friend erythroleukemia cells. Proteomics; 2006 Nov;6(21):5725-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Proteomic-based analysis of nuclear signaling: PLCbeta1 affects the expression of the splicing factor SRp20 in Friend erythroleukemia cells.
  • Constitutive overexpression of nuclear PLCbeta(1) has been previously shown to inhibit Friend erythroleukemia cells differentiation and to induce cell cycle progression targeting cyclin D3.
  • To identify novel downstream effectors of nuclear PLCbeta(1)-dependent signaling in Friend erythroleukemia cells, we performed the high-resolution 2-DE-based proteomic analysis.
  • Using a proteomic approach we found that SRp20, a member of the highly conserved SR family of splicing regulators, was down-regulated in cells overexpressing nuclear PLCbeta(1) as compared with wild-type cells.
  • Here we show the existence of a PLCbeta(1)-specific target, the splicing factor SRp20, whose expression is specifically down-regulated by the nuclear signaling evoked by PLCbeta(1).
  • [MeSH-major] Cell Nucleus / metabolism. Isoenzymes / metabolism. Leukemia, Erythroblastic, Acute / metabolism. Proteomics / methods. RNA-Binding Proteins / metabolism. Signal Transduction. Type C Phospholipases / metabolism
  • [MeSH-minor] Animals. Blotting, Western. Cells, Cultured. Down-Regulation. Electrophoresis, Gel, Two-Dimensional. Fluorescein-5-isothiocyanate. Fluorescent Antibody Technique, Direct. Fluorescent Dyes. Gene Expression Regulation, Neoplastic. Isoelectric Focusing. Mice. Microscopy, Fluorescence. Peptide Mapping. Phospholipase C beta. Precipitin Tests. Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization. Subcellular Fractions / metabolism


98. Rongies W, Bak A, Lazar A, Dolecki W, Kolanowska-Kenczew T, Sierdziński J, Spychała A, Krakowiecki A: A trial of the use of pedobarography in the assessment of the effectiveness of rehabilitation in patients with coxarthrosis. Ortop Traumatol Rehabil; 2009 May-Jun;11(3):242-52
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  • The aim of the study was to assess the progress of a selected model of rehabilitation on the basis of subpedal pressure distribution and centre of gravity sway in pedobarographic examination as well as to evaluate changes in pain intensity in patients with a history of coxarthrosis.
  • A postural pedobarographic examination was performed immediately before and after a 15-day course of rehabilitation with a PEL 38 electronic pedobarograph and computer image analyser with TWINN 99 software, version 2.08.
  • 2. The pedobarographic examination may become a new method of diagnosis and follow-up in rehabilitation.

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  • (PMID = 19620742.001).
  • [ISSN] 1509-3492
  • [Journal-full-title] Ortopedia, traumatologia, rehabilitacja
  • [ISO-abbreviation] Ortop Traumatol Rehabil
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Poland
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99. Rimmelé P, Kosmider O, Mayeux P, Moreau-Gachelin F, Guillouf C: Spi-1/PU.1 participates in erythroleukemogenesis by inhibiting apoptosis in cooperation with Epo signaling and by blocking erythroid differentiation. Blood; 2007 Apr 1;109(7):3007-14
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  • [Title] Spi-1/PU.1 participates in erythroleukemogenesis by inhibiting apoptosis in cooperation with Epo signaling and by blocking erythroid differentiation.
  • Overexpression of the transcription factor Spi-1/PU.1 in mice leads to acute erythroleukemia characterized by a differentiation block at the proerythroblastic stage.
  • In this study, we made use of a new cellular system allowing us to reach graded expression of Spi-1 in preleukemic cells to dissect mechanisms of Spi-1/ PU-1 in erythroleukemogenesis.
  • We show that Spi-1 knock-down was sufficient to reinstate the erythroid differentiation program.
  • Evidence is provided that in the presence of erythropoietin (Epo), Spi-1 displays an antiapoptotic role that is independent of its function in blocking erythroid differentiation.
  • Furthermore, we found that reducing the Spi-1 level yields to ERK dephosphorylation and increased phosphorylation of AKT and STAT5, suggesting that Spi-1 may affect major signaling pathways downstream of the EpoR in erythroid cells.
  • These findings reveal 2 distinct roles for Spi-1 during erythroleukemogenesis: Spi-1 blocks the erythroid differentiation program and acts to impair apoptotic death in cooperation with an Epo signaling.
  • [MeSH-major] Erythropoietin / physiology. Leukemia, Erythroblastic, Acute / etiology. Proto-Oncogene Proteins / physiology. Trans-Activators / physiology

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  • (PMID = 17132716.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins; 0 / RNA, Small Interfering; 0 / Receptors, Erythropoietin; 0 / Trans-Activators; 0 / proto-oncogene protein Spi-1; 11096-26-7 / Erythropoietin
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100. Kakooei H, Sameti M, Kakooei AA: Asbestos exposure during routine brake lining manufacture. Ind Health; 2007 Dec;45(6):787-92
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  • [Title] Asbestos exposure during routine brake lining manufacture.
  • Occupational exposure to asbestos fiber and total dust of workers of a major brake lining manufacture plant in a developing country were examined and compared with those in developed countries.
  • Time weighted average of total dust and asbestos fiber concentration in the potential sources of exposure were monitored.
  • All personal air sampling were collected on membrane filters and analyzed by phase contrast optical microscopy (PCM) for comparison with the occupational safety and health administration (OSHA) permissible exposure limit (PEL) of 0.1 f/cc, 8-h time--weighted average.
  • This study demonstrates that routine mixing, polishing and beveling process in the brake lining production can result in elevated levels of airborne asbestos.
  • The results also showed that the employees working in the process had the exposure to total dust concentrations ranging from 2.08 to 16.32 mg/m(3) that is higher than OSHA, recommendation.
  • During an 8-h shift, the average asbestos fiber exposure (0.78 f/cc) were 7.8 time in excess of OSHA PEL.
  • Additional studies in occupational exposure to asbestos are needed.
  • [MeSH-major] Air Pollutants, Occupational / analysis. Asbestos / analysis. Dust / analysis. Environmental Monitoring / methods. Manufactured Materials. Occupational Exposure / analysis

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  • (PMID = 18212474.001).
  • [ISSN] 0019-8366
  • [Journal-full-title] Industrial health
  • [ISO-abbreviation] Ind Health
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Air Pollutants, Occupational; 0 / Dust; 1332-21-4 / Asbestos
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