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1. Sung CO, Ko YH, Park CK, Jang KT, Heo JS: Isolated biliary granulocytic sarcoma followed by acute myelogeneous leukemia with multilineage dysplasia: a case report and literature review. J Korean Med Sci; 2006 Jun;21(3):550-4
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  • [Title] Isolated biliary granulocytic sarcoma followed by acute myelogeneous leukemia with multilineage dysplasia: a case report and literature review.
  • However, five months after the diagnosis, he developed acute myelogenous leukemia with multilineage dysplasia and chromosomal abnormality.
  • A rare possibility of biliary granulocytic sarcoma should be considered as a differential diagnosis in patients with obstructive jaundice.
  • [MeSH-major] Bile Duct Neoplasms / complications. Bile Duct Neoplasms / pathology. Leukemia, Myeloid, Acute / diagnosis. Leukemia, Myeloid, Acute / pathology. Sarcoma, Myeloid / complications. Sarcoma, Myeloid / pathology

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  • (PMID = 16778404.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2729966
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2. McElreath DP, Angtuaco TL, Staggs B, Malik AH: T cell prolymphocytic leukemia: a rare cause of acute liver failure. Dig Dis Sci; 2006 Apr;51(4):819-21
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  • [Title] T cell prolymphocytic leukemia: a rare cause of acute liver failure.
  • [MeSH-major] Leukemia, Prolymphocytic / complications. Leukemia, Prolymphocytic / diagnosis. Liver Failure, Acute / etiology. Multiple Organ Failure / diagnosis
  • [MeSH-minor] Abdominal Pain / diagnosis. Abdominal Pain / etiology. Biopsy, Needle. Combined Modality Therapy. Disease Progression. Fatal Outcome. Humans. Immunohistochemistry. Liver Function Tests. Male. Middle Aged. Rare Diseases. Risk Assessment. Severity of Illness Index

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  • (PMID = 16615010.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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3. Nau KC, Lewis WD: Multiple myeloma: diagnosis and treatment. Am Fam Physician; 2008 Oct 1;78(7):853-9
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  • [Title] Multiple myeloma: diagnosis and treatment.
  • Magnetic resonance imaging and positron emission tomography or computed tomography are emerging as useful tools in the evaluation of patients with myeloma; magnetic resonance imaging is preferred for evaluating acute spinal compression.
  • Nuclear bone scans and dual energy x-ray absorptiometry have no role in the diagnosis and staging of myeloma.
  • The differential diagnosis of monoclonal gammopathies includes monoclonal gammopathy of uncertain significance, smoldering (asymptomatic) and symptomatic multiple myeloma, amyloidosis, B-cell non-Hodgkin lymphoma, Waldenström macroglobulinemia, and rare plasma cell leukemia and heavy chain diseases.
  • [MeSH-major] Multiple Myeloma / diagnosis. Multiple Myeloma / therapy

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  • (PMID = 18841734.001).
  • [ISSN] 0002-838X
  • [Journal-full-title] American family physician
  • [ISO-abbreviation] Am Fam Physician
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Myeloma Proteins; 0 / multiple myeloma M-proteins
  • [Number-of-references] 29
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4. Brisco MJ, Latham S, Sutton R, Hughes E, Wilczek V, van Zanten K, Budgen B, Bahar AY, Malec M, Sykes PJ, Kuss BJ, Waters K, Venn NC, Giles JE, Haber M, Norris MD, Marshall GM, Morley AA: Determining the repertoire of IGH gene rearrangements to develop molecular markers for minimal residual disease in B-lineage acute lymphoblastic leukemia. J Mol Diagn; 2009 May;11(3):194-200
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  • [Title] Determining the repertoire of IGH gene rearrangements to develop molecular markers for minimal residual disease in B-lineage acute lymphoblastic leukemia.
  • Molecular markers for minimal residual disease in B-lineage acute lymphoblastic leukemia were identified by determining, at the time of diagnosis, the repertoire of rearrangements of the immunoglobulin heavy chain (IGH) gene using segment-specific variable (V), diversity (D), and junctional (J) primers in two different studies that involved a total study population of 75 children and 18 adults.
  • IGH repertoire analysis at diagnosis has potential advantages for the identification of molecular markers for the quantification of minimal residual disease in acute lymphoblastic leukemia cases.
  • [MeSH-major] Cell Lineage. Gene Rearrangement, B-Lymphocyte. Immunoglobulin Heavy Chains / genetics. Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / genetics

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  • (PMID = 19324994.001).
  • [ISSN] 1943-7811
  • [Journal-full-title] The Journal of molecular diagnostics : JMD
  • [ISO-abbreviation] J Mol Diagn
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Genetic Markers; 0 / Immunoglobulin Heavy Chains
  • [Other-IDs] NLM/ PMC2671336
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5. Hah JO: Anaplastic oligodendroglioma after childhood acute lymphoblastic leukemia: chemotherapy and autologous peripheral blood stem cell transplantation. J Pediatr Hematol Oncol; 2008 Oct;30(10):764-7
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  • [Title] Anaplastic oligodendroglioma after childhood acute lymphoblastic leukemia: chemotherapy and autologous peripheral blood stem cell transplantation.
  • Secondary brain tumors after cranial irradiation occur in survivors of childhood acute lymphoblastic leukemia (ALL).
  • We report a case of anaplastic oligodendroglioma with recurrence occurring in a 15-year-old girl, 8 years after the diagnosis of ALL.
  • [MeSH-major] Neoplasms, Second Primary / therapy. Oligodendroglioma / therapy. Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications


6. Meyer C, Ansorge N, Siglienti I, Salmen S, Stroet A, Nückel H, Dührsen U, Ritter PR, Schmidt WE, Gold R, Chan A: [Mitoxantrone-related acute leukemia by multiple sclerosis. Case report and practical approach by unclear cytopenia]. Nervenarzt; 2010 Dec;81(12):1483-9
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  • [Title] [Mitoxantrone-related acute leukemia by multiple sclerosis. Case report and practical approach by unclear cytopenia].
  • Mitoxantrone therapy-related acute leukemia (TRAL) has recently become the focus of interest.
  • METHODS: A case report of fatal TRAL following mitoxantrone therapy is presented with a discussion on the differential diagnosis and risk factors.
  • The risks are controllable under close surveillance and early diagnosis is important for prognosis.

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  • (PMID = 21079910.001).
  • [ISSN] 1433-0407
  • [Journal-full-title] Der Nervenarzt
  • [ISO-abbreviation] Nervenarzt
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Analgesics; BZ114NVM5P / Mitoxantrone
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7. Kitszel A, Krawczuk-Rybak M: Are elevated serum levels of IGFBP-2 after intensive chemotherapy of childhood acute lymphoblastic leukemia a risk factor of relapse? Adv Med Sci; 2007;52:147-53
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  • [Title] Are elevated serum levels of IGFBP-2 after intensive chemotherapy of childhood acute lymphoblastic leukemia a risk factor of relapse?
  • We studied the serum levels IGF-I, IGF-II, IGFBP-3 and IGFBP-2 (expressed in SDS) in a subgroup with relapse (A) and in a subgroup without relapse (B) at diagnosis (1), after induction of remission (2) and after intensive chemotherapy (3).
  • However, at diagnosis we obserwed a negative correlation between IGFBP-2 and hemoglobin (r = -0.57 p = 0.0001).
  • The negative correlation between values of hemoglobin and IGFBP-2 observed at diagnosis might further suggest the involvement of this protein in the process of leukemogenesis in children.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Gene Expression Regulation, Leukemic. Insulin-Like Growth Factor Binding Protein 2 / blood. Precursor Cell Lymphoblastic Leukemia-Lymphoma / blood. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy


8. Miketova P, Kaemingk K, Hockenberry M, Pasvogel A, Hutter J, Krull K, Moore IM: Oxidative changes in cerebral spinal fluid phosphatidylcholine during treatment for acute lymphoblastic leukemia. Biol Res Nurs; 2005 Jan;6(3):187-95
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  • [Title] Oxidative changes in cerebral spinal fluid phosphatidylcholine during treatment for acute lymphoblastic leukemia.
  • Central nervous system (CNS) treatment contributes to improved long-term disease-free survival from childhood acute lymphoblastic leukemia (ALL) by significantly decreasing the rate of disease relapse.
  • Phospholipids were extracted from CSF samples obtained at diagnosis and during the induction, consolidation, and continuation treatment phases.
  • [MeSH-major] Antimetabolites, Antineoplastic / adverse effects. Methotrexate / adverse effects. Phosphatidylcholines / cerebrospinal fluid. Precursor Cell Lymphoblastic Leukemia-Lymphoma / cerebrospinal fluid. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy

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  • (PMID = 15583359.001).
  • [ISSN] 1099-8004
  • [Journal-full-title] Biological research for nursing
  • [ISO-abbreviation] Biol Res Nurs
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Phosphatidylcholines; YL5FZ2Y5U1 / Methotrexate
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9. Murase T, Fujita A, Ueno H, Park JW, Yano T, Hoshikawa M, Takagi M, Kuramochi S: A case of age-related EBV-associated B-cell lymphoproliferative disorder metachronously showing two distinct morphologic appearances, one of a polymorphic disease resembling classical Hodgkin lymphoma, and the other of a large-cell lymphoma. Int J Hematol; 2009 Jan;89(1):80-5
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  • [Title] A case of age-related EBV-associated B-cell lymphoproliferative disorder metachronously showing two distinct morphologic appearances, one of a polymorphic disease resembling classical Hodgkin lymphoma, and the other of a large-cell lymphoma.
  • We report a case of age-related EBV-associated B-cell lymphoproliferative disorder (age-related EBV+ B-cell LPD) metachronously showing two distinct morphologic appearances: one of a polymorphic disease resembling classical Hodgkin lymphoma (CHL), and the other of a large-cell lymphoma.
  • Right axillary lymph node biopsy revealed mixed cellularity classical Hodgkin lymphoma (MCHL).
  • Biopsy of the right cervical mass revealed a diagnosis of diffuse large B-cell lymphoma.
  • Two years later, the patient developed acute myeloid leukemia (AML).
  • The biopsy again revealed diagnosis of MCHL.
  • Both HRS-like cells at the time of diagnosis of Hodgkin lymphoma and lymphoma cells at the time of diagnosis of non-Hodgkin lymphoma were positive for CD20 and EBV-encoded small RNAs.
  • [MeSH-major] Lymphoma, B-Cell / pathology
  • [MeSH-minor] Aged. Herpesvirus 4, Human. Hodgkin Disease / pathology. Humans. Lymph Nodes / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Male

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  • (PMID = 19093168.001).
  • [ISSN] 1865-3774
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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10. Gao F, Nordin P, Krantz I, Chia KS, Machin D: Variation in the seasonal diagnosis of acute lymphoblastic leukemia: evidence from Singapore, the United States, and Sweden. Am J Epidemiol; 2005 Oct 15;162(8):753-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Variation in the seasonal diagnosis of acute lymphoblastic leukemia: evidence from Singapore, the United States, and Sweden.
  • This study investigated, by summing data over successive years, the evidence for the seasonal diagnosis of acute lymphoblastic leukemia.
  • To do so, the authors estimated the dates of peak diagnosis over a range of geographic locations including Singapore (1968-1999), Hawaii and mainland United States (1973-1999), and western Sweden (1977-1994) at latitudes of 1.16 degrees N to 58.24 degrees N.
  • Thus, despite a wide geographic range of localities, there is little evidence of any seasonality in the diagnosis of acute lymphoblastic leukemia in most populations studied and no strong evidence of any influence of climate (as expressed by latitude).
  • [MeSH-major] Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis. Seasons

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  • (PMID = 16135507.001).
  • [ISSN] 0002-9262
  • [Journal-full-title] American journal of epidemiology
  • [ISO-abbreviation] Am. J. Epidemiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] United States
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11. Tsai MH, Yang CP, Chung HT, Shih LY: Acute myeloid leukemia in a young girl presenting with mediastinal granulocytic sarcoma invading pericardium and causing superior vena cava syndrome. J Pediatr Hematol Oncol; 2009 Dec;31(12):980-2
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  • [Title] Acute myeloid leukemia in a young girl presenting with mediastinal granulocytic sarcoma invading pericardium and causing superior vena cava syndrome.
  • A 1-year-4-month-old girl who presented with pericardial effusion and superior vena cava (SVC) syndrome caused by a mediastinal mass was later proved to be a case of acute myeloid leukemia (AML) with mixed-lineage leukemia-gene translocation.
  • The unusual presentation and the giant blasts with basophilic vacuolated cytoplasm had led to initial misdiagnosis of mediastinal lymphoma.
  • To our knowledge, this is the first reported case of childhood acute myeloid leukemia presenting with mediastinal granulocytic sarcoma causing pericardium invasion and SVC syndrome.
  • [MeSH-major] Leukemia, Myeloid, Acute / pathology. Mediastinal Neoplasms / diagnosis. Pericardium / pathology. Sarcoma, Myeloid / diagnosis. Superior Vena Cava Syndrome / diagnosis
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Diagnosis, Differential. Fatal Outcome. Female. Humans. Infant. Pericardial Effusion / etiology


12. Higashida T, Kawasaki T, Sakata K, Tanabe Y, Kanno H, Yamamoto I: Acute lymphocytic leukemia recurring in the spinal epidural space. Neurol Med Chir (Tokyo); 2007 Aug;47(8):375-8
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  • [Title] Acute lymphocytic leukemia recurring in the spinal epidural space.
  • A 27-year-old man presented with a very rare spinal epidural mass associated with recurrence of acute lymphocytic leukemia (ALL) manifesting as acute progressive neurological deficits.
  • Leukemic mass must be considered in the differential diagnosis of spinal epidural mass, even in patients with ALL.
  • [MeSH-major] Epidural Neoplasms / secondary. Epidural Space / pathology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology. Spinal Cord Compression / etiology. Spinal Neoplasms / secondary

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  • (PMID = 17721056.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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13. Carroll WL, Bhojwani D, Min DJ, Moskowitz N, Raetz EA: Childhood acute lymphoblastic leukemia in the age of genomics. Pediatr Blood Cancer; 2006 May 1;46(5):570-8
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  • [Title] Childhood acute lymphoblastic leukemia in the age of genomics.
  • Mechanistic insights into treatment failure have come from the definition of mRNA signatures that predict in vitro chemoresistance, as well as differences between blasts at relapse and new diagnosis.
  • [MeSH-major] Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics

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  • (PMID = 16365862.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / U01CA114762
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neoplasm Proteins
  • [Number-of-references] 44
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14. Schmidmaier R, Baumann P: ANTI-ADHESION evolves to a promising therapeutic concept in oncology. Curr Med Chem; 2008;15(10):978-90
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  • Furthermore, cell adhesion mediates drug resistance (CAM-DR) in multiple myeloma, malignant lymphoma, acute and chronic leukaemias, as well as in pancreatic cancer, neuroblastoma, small cell and non-small cell lung cancer, mesothelioma, colorectal carcinoma, and breast cancer.


15. Roncador G, García Verdes-Montenegro JF, Tedoldi S, Paterson JC, Klapper W, Ballabio E, Maestre L, Pileri S, Hansmann ML, Piris MA, Mason DY, Marafioti T: Expression of two markers of germinal center T cells (SAP and PD-1) in angioimmunoblastic T-cell lymphoma. Haematologica; 2007 Aug;92(8):1059-66
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  • [Title] Expression of two markers of germinal center T cells (SAP and PD-1) in angioimmunoblastic T-cell lymphoma.
  • We document its expression, and also that of PD-1 (another recently described marker of germinal center T cells to which a new antibody has been raised), in normal and neoplastic lymphoid tissue to evaluate the suggestion that helper T cells within the germinal centers of human lymphoid tissue are the cell of origin of angioimmunoblastic T-cell lymphoma (AITL), and to assess the diagnostic value of these two markers.
  • RESULTS Screening on more than 500 lymphoma biopsies showed that 95% (40/42) of cases of AITL expressed at least one of these markers.
  • SAP was also expressed on many cases (15/21) of acute T lymphoblastic leukemia, in keeping with its presence in cortical thymocytes.
  • However, PD-1 and SAP were also found in a minority of cases of peripheral T-cell lymphoma other than AITL, in contrast to a report that the former marker is specific for AITL.
  • They may also prove of value in the diagnosis of this disease since a negative reaction was rarely observed in this disorder.
  • [MeSH-major] Adaptor Proteins, Signal Transducing / analysis. Antigens, CD / analysis. Antigens, Differentiation, T-Lymphocyte / analysis. Apoptosis Regulatory Proteins / analysis. Germinal Center / pathology. Immunoblastic Lymphadenopathy / pathology. Intracellular Signaling Peptides and Proteins / analysis. Lymphoma, T-Cell / pathology. Neoplasm Proteins / analysis. T-Lymphocytes / chemistry
  • [MeSH-minor] Hodgkin Disease / metabolism. Hodgkin Disease / pathology. Humans. Lymphocytes, Tumor-Infiltrating / chemistry. Lymphocytes, Tumor-Infiltrating / pathology. Lymphoma, B-Cell / chemistry. Lymphoma, B-Cell / pathology. Palatine Tonsil / pathology. Programmed Cell Death 1 Receptor. Spleen / pathology. Thymus Gland / pathology

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  • (PMID = 17640856.001).
  • [ISSN] 1592-8721
  • [Journal-full-title] Haematologica
  • [ISO-abbreviation] Haematologica
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Antigens, CD; 0 / Antigens, Differentiation, T-Lymphocyte; 0 / Apoptosis Regulatory Proteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / Neoplasm Proteins; 0 / PDCD1 protein, human; 0 / Programmed Cell Death 1 Receptor; 0 / SH2D1A protein, human
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16. Szawarski P, Chapman CS: A woman who couldn't speak: report of methotrexate neurotoxicity. Postgrad Med J; 2005 Mar;81(953):194-5
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  • This case illustrates the importance of considering the diagnosis of methotrexate toxicity in an adult patient with behavioural and speech disturbances, who received it by intrathecal route only and in whom the only indicator was an abnormal electroencephalographic study.
  • [MeSH-minor] Acute Disease. Adult. Female. Humans. Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy

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  • (PMID = 15749798.001).
  • [ISSN] 1469-0756
  • [Journal-full-title] Postgraduate medical journal
  • [ISO-abbreviation] Postgrad Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; YL5FZ2Y5U1 / Methotrexate
  • [Other-IDs] NLM/ PMC1743219
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17. Järvelä LS, Niinikoski H, Lähteenmäki PM, Heinonen OJ, Kapanen J, Arola M, Kemppainen J: Physical activity and fitness in adolescent and young adult long-term survivors of childhood acute lymphoblastic leukaemia. J Cancer Surviv; 2010 Dec;4(4):339-45
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  • [Title] Physical activity and fitness in adolescent and young adult long-term survivors of childhood acute lymphoblastic leukaemia.
  • INTRODUCTION: There is a lack of data on physical activity (PA) and fitness of adolescent and young adult very long-term survivors of childhood acute lymphoblastic leukemia (ALL).
  • METHODS: We studied 21 childhood ALL long-term survivors (aged 16-30 years, median time since diagnosis 15.9 y), diagnosed in 1986-1996, with age- and sex-matched controls.
  • [MeSH-major] Motor Activity. Physical Fitness. Precursor Cell Lymphoblastic Leukemia-Lymphoma / rehabilitation. Survivors / statistics & numerical data

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  • (PMID = 20552291.001).
  • [ISSN] 1932-2267
  • [Journal-full-title] Journal of cancer survivorship : research and practice
  • [ISO-abbreviation] J Cancer Surviv
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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18. Yin HQ, Qiao ZH, Zhu L, Zhang L, Su LP, Lu YJ: [Levels of intracellular IL-6 and IFN-gamma in children with acute lymphoblastic leukemia]. Zhongguo Dang Dai Er Ke Za Zhi; 2006 Dec;8(6):461-3
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  • [Title] [Levels of intracellular IL-6 and IFN-gamma in children with acute lymphoblastic leukemia].
  • OBJECTIVE: To study the changes of intracellular interleukin-6 (IL-6) and interferon-gamma (IFN-gamma) expressions in children with acute lymphoblastic leukemia (ALL) at different stages, and to examine the correlation between IL-6 and IFN-gamma in ALL children.
  • METHODS: The levels of intracellular IL-6 and IFN-gamma in venous blood lymphocytes were detected by flow cytometry in 42 children with ALL at diagnosis and at remission stage.
  • RESULTS: The intracellular IL-6 level in ALL children at diagnosis was 81.74+/-9.31, which was much higher than that in the Control group (5.67 +/- 0.96 ) (P < 0.01).
  • In contrast, the intracellular IFN-gamma level (1.97 +/- 0.72) increased noticeably in ALL patients at remission stage, which was higher than that at diagnosis and the Control group (P < 0.01).
  • [MeSH-major] Interferon-gamma / blood. Interleukin-6 / blood. Leukocytes, Mononuclear / chemistry. Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology

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  • (PMID = 17178034.001).
  • [ISSN] 1008-8830
  • [Journal-full-title] Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
  • [ISO-abbreviation] Zhongguo Dang Dai Er Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Interleukin-6; 82115-62-6 / Interferon-gamma
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19. Saito T, Usui N, Asai O, Yano S, Sugiyama K, Hisatomi M, Ueda K, Dobashi N, Kobayashi M: Toxicity and outcome of intensive chemotherapy for acute lymphoblastic leukemia complicated with Turner's syndrome. Intern Med; 2005 Feb;44(2):145-8
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  • [Title] Toxicity and outcome of intensive chemotherapy for acute lymphoblastic leukemia complicated with Turner's syndrome.
  • A 17-year-old woman was diagnosed as acute lymphoblastic leukemia (ALL).
  • As she had chromosomal abnormalities of 44, XO, der(9)t(3;9)(q11;p13), der(10;19)(q10;p10), del(15)(q15), -16, -19, +22 with the presence of ovarian dysplasia and abnormal physical features, a diagnosis of Turner's syndrome was made.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / adverse effects. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Turner Syndrome / complications
  • [MeSH-minor] Adolescent. Chromosomes, Human, X / genetics. Diagnosis, Differential. Dose-Response Relationship, Drug. Female. Follow-Up Studies. Humans. Karyotyping. Liver / drug effects. Remission Induction. Sex Chromosome Aberrations. Treatment Outcome

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  • (PMID = 15750276.001).
  • [ISSN] 0918-2918
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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20. Waber DP, Turek J, Catania L, Stevenson K, Robaey P, Romero I, Adams H, Alyman C, Jandet-Brunet C, Neuberg DS, Sallan SE, Silverman LB: Neuropsychological outcomes from a randomized trial of triple intrathecal chemotherapy compared with 18 Gy cranial radiation as CNS treatment in acute lymphoblastic leukemia: findings from Dana-Farber Cancer Institute ALL Consortium Protocol 95-01. J Clin Oncol; 2007 Nov 1;25(31):4914-21
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  • [Title] Neuropsychological outcomes from a randomized trial of triple intrathecal chemotherapy compared with 18 Gy cranial radiation as CNS treatment in acute lymphoblastic leukemia: findings from Dana-Farber Cancer Institute ALL Consortium Protocol 95-01.
  • PURPOSE: We evaluated late neuropsychological toxicity in children treated for standard-risk acute lymphoblastic leukemia (ALL) who were randomly assigned to receive either cranial radiation therapy (CRT) with double intrathecal (IT) chemotherapy or intensive triple IT chemotherapy (no CRT) as CNS-directed therapy.
  • CONCLUSION: This randomized trial revealed only subtle differences 6 years after diagnosis between children who received CNS therapy as CRT plus double IT drug or as intensive triple IT drug.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / adverse effects. Central Nervous System Diseases / diagnosis. Central Nervous System Neoplasms / therapy. Cranial Irradiation / adverse effects. Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy

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  • [ErratumIn] J Clin Oncol. 2008 Feb 1;26(4):694. Dosage error in published abstract; MEDLINE/PubMed abstract corrected; Dosage error in article text
  • (PMID = 17971588.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glucocorticoids; 04079A1RDZ / Cytarabine; WI4X0X7BPJ / Hydrocortisone; YL5FZ2Y5U1 / Methotrexate
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21. Gonçalves M, Terreri MT, Barbosa CM, Len CA, Lee L, Hilário MO: Diagnosis of malignancies in children with musculoskeletal complaints. Sao Paulo Med J; 2005 Jan 2;123(1):21-3
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  • [Title] Diagnosis of malignancies in children with musculoskeletal complaints.
  • When these symptoms predominate at the onset of the disease, the differential diagnosis includes several rheumatic diseases.
  • METHODS: The medical records of patients with musculoskeletal complaints and final diagnosis of malignant disease were reviewed.
  • The data collected were: age when symptoms initially presented, age at diagnosis, clinical features presented, laboratory findings, and the initial and final diagnoses.
  • RESULTS: A final diagnosis of cancer was found in nine out of 3,528 patients (0.25%) whose initial symptom was musculoskeletal pain.
  • The mean time between disease onset and final diagnosis was five months.
  • Juvenile rheumatoid arthritis was the most frequent initial diagnosis, in four out of nine patients.
  • The malignancies found included acute lymphocytic leukemia, acute myeloid leukemia, lymphoma, neuroblastoma and Ewing's sarcoma.
  • Uncharacteristic clinical manifestations and nonspecific laboratory tests may cause difficulty in the final diagnosis, and rigorous investigation should be performed.

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  • [ErratumIn] Sao Paulo Med J. 2005 Mar 2;123(2):49
  • (PMID = 15821811.001).
  • [ISSN] 1516-3180
  • [Journal-full-title] São Paulo medical journal = Revista paulista de medicina
  • [ISO-abbreviation] Sao Paulo Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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22. Oztürkmen S, Akyay A, Biçakçi Z, Karakoç Y, Arikan SM, Celebi-Tayfur A, Ağladioğlu S, Olcay L: Delayed diagnosis of acute leukemia in a patient with bone pain and fracture. Turk J Pediatr; 2010 Sep-Oct;52(5):552-5
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  • [Title] Delayed diagnosis of acute leukemia in a patient with bone pain and fracture.
  • In childhood acute lymphoblastic leukemia (ALL), non-hematological manifestations involving the musculoskeletal system can also be encountered.
  • These manifestations may cause a delay in the diagnosis of leukemia.
  • [MeSH-major] Bone Diseases, Metabolic / etiology. Fractures, Spontaneous / etiology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications. Radius Fractures / etiology
  • [MeSH-minor] Child. Delayed Diagnosis. Humans. Male

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  • (PMID = 21434546.001).
  • [ISSN] 0041-4301
  • [Journal-full-title] The Turkish journal of pediatrics
  • [ISO-abbreviation] Turk. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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23. Ibrahim K, Daud SS, Seah YL, Yeoh AE, Ariffin H, Malaysia-Singapore Leukemia Study Group: Rapid detection of prognostically important childhood acute lymphoblastic leukemia chimeric transcripts using multiplex SYBR green real-time reverse transcription PCR. Ann Clin Lab Sci; 2008;38(4):338-43
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  • [Title] Rapid detection of prognostically important childhood acute lymphoblastic leukemia chimeric transcripts using multiplex SYBR green real-time reverse transcription PCR.
  • Childhood acute lymphoblastic leukaemia (ALL) is a heterogenous disease in which oncogene fusion transcripts are known to influence the biological behaviour of the different ALL subtypes.
  • [MeSH-major] Core Binding Factor Alpha 2 Subunit / genetics. Fusion Proteins, bcr-abl / genetics. Homeodomain Proteins / genetics. Myeloid-Lymphoid Leukemia Protein / genetics. Oncogene Proteins, Fusion / genetics. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics. Reverse Transcriptase Polymerase Chain Reaction / methods
  • [MeSH-minor] Child. Female. Humans. Karyotyping. Male. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / genetics. RNA, Messenger / metabolism. RNA, Neoplasm / metabolism. Translocation, Genetic

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  • (PMID = 18988926.001).
  • [ISSN] 1550-8080
  • [Journal-full-title] Annals of clinical and laboratory science
  • [ISO-abbreviation] Ann. Clin. Lab. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Core Binding Factor Alpha 2 Subunit; 0 / Homeodomain Proteins; 0 / MLL-AF4 fusion protein, human; 0 / Oncogene Proteins, Fusion; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / TEL-AML1 fusion protein; 146150-85-8 / E2A-Pbx1 fusion protein; 149025-06-9 / Myeloid-Lymphoid Leukemia Protein; EC 2.7.10.2 / Fusion Proteins, bcr-abl
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24. Bidegain F, Berry A, Alvarez M, Verhille O, Huguet F, Brousset P, Pris J, Marchou B, Magnaval JF: Acute Plasmodium falciparum malaria following splenectomy for suspected lymphoma in 2 patients. Clin Infect Dis; 2005 Jun 1;40(11):e97-100
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  • [Title] Acute Plasmodium falciparum malaria following splenectomy for suspected lymphoma in 2 patients.
  • Two black African immigrants, with no history of recent travel outside France, received a diagnosis of a malignant lymphoproliferative disorder and splenomegaly, and they subsequently underwent splenectomy.
  • A few weeks after surgery, both patients experienced an acute episode of Plasmodium falciparum malaria, so the initial diagnosis was corrected retrospectively and changed to hyperreactive malarial splenomegaly.
  • [MeSH-major] Malaria, Falciparum / diagnosis. Splenectomy
  • [MeSH-minor] Adult. Cameroon. Central African Republic. Emigration and Immigration. France. Humans. Splenomegaly / diagnosis. Splenomegaly / parasitology. Splenomegaly / surgery

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  • (PMID = 15889352.001).
  • [ISSN] 1537-6591
  • [Journal-full-title] Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • [ISO-abbreviation] Clin. Infect. Dis.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Gorsane I, Bourkhis L, Laatiri MA, Aloui S, Letaif A, Haouala F, Ben Dhia N, Frih A, Zakhama A, Elmay M, Skhiri H: [Acute renal failure caused by renal lymphoma. A case report]. Nephrol Ther; 2010 Apr;6(2):132-6
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  • [Title] [Acute renal failure caused by renal lymphoma. A case report].
  • Acute renal failure, as the initial manifestation of lymphoma, has been reported only in a few cases.
  • In this work, we report the case of a 28-year-old women admitted for acute renal failure.
  • A diagnosis of diffuse large B-cell type non-Hodgkin lymphoma was made.
  • However, investigations revealed the presence of two others sites of lymphoma: gastric and ophthalmic.
  • The patient's renal function and kidney size as well as the other lymphoma locations were normalized after the initiation of chemotherapy.
  • [MeSH-major] Acute Kidney Injury / etiology. Eye Neoplasms / diagnosis. Kidney Neoplasms / diagnosis. Lymphoma, Large B-Cell, Diffuse / diagnosis. Neoplasms, Multiple Primary / diagnosis. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Adult. Antigens, CD20 / blood. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / blood. Diagnosis, Differential. Female. Humans. Treatment Outcome

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  • [Copyright] Copyright 2010 Association Société de néphrologie. Published by Elsevier SAS. All rights reserved.
  • (PMID = 20299297.001).
  • [ISSN] 1872-9177
  • [Journal-full-title] Néphrologie & thérapeutique
  • [ISO-abbreviation] Nephrol. Ther.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / Biomarkers, Tumor
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26. Burmeister T, Gökbuget N, Schwartz S, Fischer L, Hubert D, Sindram A, Hoelzer D, Thiel E: Clinical features and prognostic implications of TCF3-PBX1 and ETV6-RUNX1 in adult acute lymphoblastic leukemia. Haematologica; 2010 Feb;95(2):241-6
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  • [Title] Clinical features and prognostic implications of TCF3-PBX1 and ETV6-RUNX1 in adult acute lymphoblastic leukemia.
  • BACKGROUND: The t(9;22) and t(4;11) chromosomal translocations, which generate the BCR-ABL and MLL-AF4 fusion genes, define high-risk subtypes of acute lymphoblastic leukemia in adults.
  • However, the prognostic impact of other rarer fusion genes is less well established in adult acute lymphoblastic leukemia than in the childhood form.
  • DESIGN AND METHODS: In the context of the German Multicenter Therapy Study Group for Adult Acute Lymphoblastic Leukemia (GMALL) we used reverse transcriptase polymerase chain reaction to investigate 441 cases of BCR-ABL- and MLL-AF4-negative B-precursor acute lymphoblastic leukemia for the TCF3-PBX1 (E2A-PBX1) and ETV6-RUNX1 (TEL-AML1) fusion transcripts generated by the t(1;19)(q23;p13.3) and t(12;21)(p13;q22) translocations.
  • Both are well-known molecular alterations in pediatric acute lymphoblastic leukemia in which they have favorable prognostic implications.
  • At 2 years after diagnosis all the ETV6-RUNX1-positive patients were alive and in continuous complete remission, but their long-term outcome was negatively affected by late relapses.
  • CONCLUSIONS: In contrast to previous suggestions, adult patients with TCF3-PBX1-positive acute lymphoblastic leukemia do not appear to have a worse outcome than their negative counterparts.
  • [MeSH-major] Oncogene Proteins, Fusion. Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis

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  • (PMID = 19713226.001).
  • [ISSN] 1592-8721
  • [Journal-full-title] Haematologica
  • [ISO-abbreviation] Haematologica
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Core Binding Factor Alpha 2 Subunit; 0 / MLL-AF4 fusion protein, human; 0 / Oncogene Proteins, Fusion; 0 / TCF3-PBX1 fusion protein, human; 0 / TEL-AML1 fusion protein; 0 / abl-bcr fusion protein, human; 149025-06-9 / Myeloid-Lymphoid Leukemia Protein; EC 2.7.10.2 / Fusion Proteins, bcr-abl
  • [Other-IDs] NLM/ PMC2817026
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27. Kars MC, Duijnstee MS, Pool A, van Delden JJ, Grypdonck MH: Being there: parenting the child with acute lymphoblastic leukaemia. J Clin Nurs; 2008 Jun;17(12):1553-62
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  • [Title] Being there: parenting the child with acute lymphoblastic leukaemia.
  • BACKGROUND: Diagnosis of leukaemia in children leads to an existential shock for parents and a reversal of normal family life.
  • Today, in the Netherlands, after diagnosis, children stay at home most of the time.
  • RELEVANCE TO CLINICAL PRACTICE: The concept offers an essential insight into parenting the child with acute lymphoblastic leukaemia and has relevance for nursing practice and education.
  • [MeSH-major] Attitude to Health. Parent-Child Relations. Parenting / psychology. Parents / psychology. Precursor Cell Lymphoblastic Leukemia-Lymphoma

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  • (PMID = 18482117.001).
  • [ISSN] 1365-2702
  • [Journal-full-title] Journal of clinical nursing
  • [ISO-abbreviation] J Clin Nurs
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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28. Matutes E: Adult T-cell leukaemia/lymphoma. J Clin Pathol; 2007 Dec;60(12):1373-7
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  • [Title] Adult T-cell leukaemia/lymphoma.
  • Adult T-cell leukaemia/lymphoma (ATLL) is a mature T-cell neoplasm of post-thymic lymphocytes aetiologically linked to the human T-cell lymphotropic virus, HTLV-I, and with a distinct geographical distribution.
  • According to the disease manifestations, various forms which differ in clinical course and prognosis have been recognised: acute, chronic, smouldering and lymphoma.
  • The diagnosis should be based on a constellation of clinical features and laboratory investigations.
  • The latter comprise: lymphocyte morphology, immunophenotype, histology of the tissues affected in the pure lymphoma forms and serology or DNA analysis for HTLV-I.
  • The differential diagnosis of ATLL includes other mature T-cell neoplasms such as T-cell prolymphocytic leukaemia (T-PLL), Sézary syndrome (SS), peripheral T-cell lymphomas and occasionally healthy carriers of the virus or Hodgkin disease.
  • The clinical course is aggressive with a median survival of less than 12 months in the acute and lymphoma forms.
  • [MeSH-major] Leukemia-Lymphoma, Adult T-Cell / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Antiviral Agents / therapeutic use. Biomarkers, Tumor / blood. Diagnosis, Differential. Drug Therapy, Combination. Humans. Immunophenotyping. Prognosis

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  • (PMID = 18042693.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antiviral Agents; 0 / Biomarkers, Tumor
  • [Number-of-references] 42
  • [Other-IDs] NLM/ PMC2095573
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29. Cleaver AL, Beesley AH, Firth MJ, Sturges NC, O'Leary RA, Hunger SP, Baker DL, Kees UR: Gene-based outcome prediction in multiple cohorts of pediatric T-cell acute lymphoblastic leukemia: a Children's Oncology Group study. Mol Cancer; 2010 May 12;9:105
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  • [Title] Gene-based outcome prediction in multiple cohorts of pediatric T-cell acute lymphoblastic leukemia: a Children's Oncology Group study.
  • BACKGROUND: Continuous complete clinical remission in T-cell acute lymphoblastic leukemia (T-ALL) is now approaching 80% due to the implementation of aggressive chemotherapy protocols but patients that relapse continue to have a poor prognosis.
  • Such patients could benefit from augmented therapy if their clinical outcome could be more accurately predicted at the time of diagnosis.
  • CONCLUSIONS: We have used two different approaches to identify, for the first time, robust gene signatures that can successfully discriminate relapse and CCR patients at the time of diagnosis across multiple patient cohorts and platforms.

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  • (PMID = 20459861.001).
  • [ISSN] 1476-4598
  • [Journal-full-title] Molecular cancer
  • [ISO-abbreviation] Mol. Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA114766; United States / NCI NIH HHS / CA / CA95475; United States / NCI NIH HHS / CA / CA98543
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / NF-kappa B; 0 / Receptors, Interleukin-7; 0 / Wnt Proteins
  • [Other-IDs] NLM/ PMC2879253
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30. Miron I, Mihăilă D, Aprodu G, Miron L, Plămădeală P, Moisă SM: Immunoproliferative small intestinal disease versus colonic monoblastic sarcoma in a 2-year-old boy. Rom J Morphol Embryol; 2009;50(4):733-8
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  • Important similitudes with immunoproliferative small intestinal disease (IPSID) lymphoma were demonstrated for this patient (male, 2-year-old).
  • Some particularities of this case are the young age and the extremely rapid development of the malignant disease in a patient with no previous signs of acute non-lymphoblastic leukemia.
  • The initial diagnosis was of malabsorbtion syndrome, based on the clinical exam at presentation, and then the patient was thought to have a form of Hirschprung's disease, due to a functional intestinal disorder (slow transit).
  • [MeSH-major] Colonic Neoplasms / diagnosis. Immunoproliferative Small Intestinal Disease / diagnosis. Sarcoma / diagnosis
  • [MeSH-minor] Child, Preschool. Diagnosis, Differential. Hirschsprung Disease / diagnosis. Humans. Malabsorption Syndromes / diagnosis. Male

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  • (PMID = 19942975.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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31. Advani AS, Jin T, Ramsingh G, Tiu R, Saber W, Theil K, Sobecks R, Sekeres M, Copelan E, Sungren S, Tripp B, Kalaycio M: Time to post-remission therapy is an independent prognostic factor in adults with acute lymphoblastic leukemia. Leuk Lymphoma; 2008 Aug;49(8):1560-6
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  • [Title] Time to post-remission therapy is an independent prognostic factor in adults with acute lymphoblastic leukemia.
  • On univariate analysis, significant prognostic factors included: age at diagnosis (per 10-year increase), poor risk cytogenetics, time to white blood count recovery, and time from induction chemotherapy (IC) to post-remission therapy (PRT).
  • [MeSH-major] Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis. Precursor Cell Lymphoblastic Leukemia-Lymphoma / mortality

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  • (PMID = 18766970.001).
  • [ISSN] 1029-2403
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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32. Niparuck P, Kanoksil W, Chuncharunee S, Boonsakan P, Ungkanont A, Angchaisuksiri P, Karntisaviwat K, Apilugsanachit A, Rerkamnuatchoke B, Jootar S, Nitiyanant P, Atichartakarn V: Therapy-related myelodysplastic syndrome/acute myeloid leukemia following fludarabine therapy for non-Hodgkin lymphoma and chronic lymphocytic leukemia in Thai patients. Leuk Lymphoma; 2010 Nov;51(11):2120-5
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  • [Title] Therapy-related myelodysplastic syndrome/acute myeloid leukemia following fludarabine therapy for non-Hodgkin lymphoma and chronic lymphocytic leukemia in Thai patients.
  • [MeSH-major] Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy. Leukemia, Myeloid, Acute / chemically induced. Lymphoma, Non-Hodgkin / drug therapy. Myelodysplastic Syndromes / chemically induced. Vidarabine / analogs & derivatives
  • [MeSH-minor] Adult. Aged. Antineoplastic Agents / adverse effects. Antineoplastic Agents / therapeutic use. Female. Humans. Male. Middle Aged. Neoplasms, Second Primary / chemically induced. Neoplasms, Second Primary / diagnosis. Neoplasms, Second Primary / epidemiology. Prognosis. Retrospective Studies. Thailand / epidemiology. Young Adult


33. von Stackelberg A, Hartmann R, Bührer C, Fengler R, Janka-Schaub G, Reiter A, Mann G, Schmiegelow K, Ratei R, Klingebiel T, Ritter J, Henze G, ALL-REZ BFM Study Group: High-dose compared with intermediate-dose methotrexate in children with a first relapse of acute lymphoblastic leukemia. Blood; 2008 Mar 1;111(5):2573-80
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  • [Title] High-dose compared with intermediate-dose methotrexate in children with a first relapse of acute lymphoblastic leukemia.
  • High-dose methotrexate (MTX) has been extensively used for treatment of acute lymphoblastic leukemia (ALL).
  • A total of 269 children with a first early/late isolated (n = 156) or combined (n = 68) bone marrow or any isolated extramedullary relapse (n = 45) of precursor B-cell (PBC) ALL (excluding very early marrow relapse within 18 months after initial diagnosis) were registered at the ALL-REZ BFM90 trial and randomized to receive methotrexate infusions at either 1 g/m(2) over 36 hours (intermediate dose, ID) or 5 g/m(2) over 24 hours (high dose, HD) during 6 (or 4) intensive polychemotherapy courses.
  • In conclusion, methotrexate infusions at 5 g/m(2) per 24 hours, compared with 1 g/m(2) per 36 hours, are not associated with increased disease control in relapsed childhood PBC acute lymphoblastic leukemia.
  • [MeSH-major] Methotrexate / administration & dosage. Methotrexate / therapeutic use. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Precursor Cell Lymphoblastic Leukemia-Lymphoma / prevention & control

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  • [CommentIn] Blood. 2008 Aug 1;112(3):910 [18650464.001]
  • (PMID = 18089849.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; YL5FZ2Y5U1 / Methotrexate
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34. Koschmann C, Thomson B, Hawkins DS: No evidence of a trial effect in newly diagnosed pediatric acute lymphoblastic leukemia. Arch Pediatr Adolesc Med; 2010 Mar;164(3):214-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] No evidence of a trial effect in newly diagnosed pediatric acute lymphoblastic leukemia.
  • PARTICIPANTS: Data were drawn from 322 patients with newly diagnosed acute lymphoblastic leukemia.
  • (1) Demographic variables associated with trial participation. (2) Event-free survival, which was defined as the time from initial diagnosis to either leukemia recurrence or death from any cause.
  • CONCLUSIONS: Clinical trial participation does not, by itself, lead to improved outcome for pediatric patients with acute lymphoblastic leukemia in the current era.
  • [MeSH-major] Clinical Trials as Topic. Health Knowledge, Attitudes, Practice. Precursor Cell Lymphoblastic Leukemia-Lymphoma / mortality. Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy

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  • [CommentIn] Arch Pediatr Adolesc Med. 2010 Mar;164(3):293-4 [20194266.001]
  • [CommentIn] Arch Pediatr Adolesc Med. 2010 Sep;164(9):882; author reply 882-3 [20819974.001]
  • (PMID = 20194252.001).
  • [ISSN] 1538-3628
  • [Journal-full-title] Archives of pediatrics & adolescent medicine
  • [ISO-abbreviation] Arch Pediatr Adolesc Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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35. Uozumi K: Treatment of adult T-cell leukemia. J Clin Exp Hematop; 2010;50(1):9-25
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  • Treatment of the aggressive forms (acute and lymphoma types) of ATL remains inadequate, as most ATL patients receive conventional chemotherapy without stem cell rescue.
  • [MeSH-major] Hematopoietic Stem Cell Transplantation. Leukemia-Lymphoma, Adult T-Cell / therapy

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  • (PMID = 20505272.001).
  • [ISSN] 1880-9952
  • [Journal-full-title] Journal of clinical and experimental hematopathology : JCEH
  • [ISO-abbreviation] J Clin Exp Hematop
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
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36. Fatimi S, Sheikh S, Shah Z, Shafiq M: Intra-cardiac Burkitt's lymphoma mimicking acute pulmonary embolism. J Coll Physicians Surg Pak; 2006 Aug;16(8):536-7
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  • [Title] Intra-cardiac Burkitt's lymphoma mimicking acute pulmonary embolism.
  • Primary cardiac lymphoma is a rare clinical entity with poor prognosis and delayed diagnosis is often due to variable and non-specific clinical presentation.
  • The case of an elderly male is reported with multiple co-morbidities, who had undergone a spinal laminectomy two weeks prior to presentation, later presented to the emergency room (E.R.) with acute chest pain, dyspnea and hypoxemia.
  • A diagnosis of intracardiac thrombus was made, based on the clinical picture and echocardiography findings but per-operatively, he was found to have an extensive, non-resectable cardiac tumor.
  • [MeSH-major] Burkitt Lymphoma / diagnosis. Heart Neoplasms / diagnosis. Pulmonary Embolism / diagnosis
  • [MeSH-minor] Acute Disease. Aged. Cardiopulmonary Bypass. Diagnosis, Differential. Echocardiography. Embolectomy. Fatal Outcome. Heart Ventricles / pathology. Humans. Male. Pulmonary Veins / pathology

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  • (PMID = 16899184.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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37. López-Vicente J, Pérez-Carreras M, Idrovo F: [Acute cholestasis in an immunosuppressed patient with renal transplantation and chronic hepatitis C]. Med Clin (Barc); 2010 Apr 10;134(10):457-61
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  • [Title] [Acute cholestasis in an immunosuppressed patient with renal transplantation and chronic hepatitis C].
  • [MeSH-major] Burkitt Lymphoma. Cholestasis, Extrahepatic. Hepatitis, Chronic. Kidney Transplantation
  • [MeSH-minor] Acute Disease. Biopsy. Cholangiopancreatography, Endoscopic Retrograde. Diagnosis, Differential. Humans. Immunocompromised Host. Liver / pathology. Radiography, Abdominal. Remission Induction. Tomography, X-Ray Computed. Viral Load


38. Elsayes KM, Oliveira EP, Narra VR, El-Merhi FM, Brown JJ: Magnetic resonance imaging of the gallbladder: spectrum of abnormalities. Acta Radiol; 2007 Jun;48(5):476-82
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  • Various pathologies involving the gallbladder can manifest clinically, producing nonspecific clinical symptoms and making diagnosis difficult and challenging.
  • Understanding the basic patterns of various disease manifestations and appearance on MRI is the key to making an accurate diagnosis.
  • Gallbladder pathology can be classified into congenital (such as absence), inflammatory (acute, hemorrhagic, and chronic cholecystitis), traumatic, benign (polyps) and malignant tumors (gallbladder carcinoma and lymphoma), and other disease processes can be seen in cholelithiasis, cholesterosis, thickened gallbladder wall, and Mirrizzi syndrome.
  • [MeSH-major] Cholangiopancreatography, Magnetic Resonance. Gallbladder Diseases / diagnosis. Magnetic Resonance Imaging
  • [MeSH-minor] Acute Disease. Adenomyoma. Carcinoma / diagnosis. Cholecystitis / diagnosis. Cholelithiasis / diagnosis. Chronic Disease. Cystadenoma / diagnosis. Gallbladder / abnormalities. Gallbladder Neoplasms / diagnosis. Hemorrhage / diagnosis. Humans. Lymphoma / diagnosis. Polyps / diagnosis

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  • (PMID = 17520421.001).
  • [ISSN] 0284-1851
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
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39. Testini M, Vacca A, Lissidini G, Di Venere B, Gurrado A, Loizzi M: Acute intrathoracic gastric volvulus from a diaphragmatic hernia after left splenopancreatectomy: Report of a case. Surg Today; 2006;36(11):981-4
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  • [Title] Acute intrathoracic gastric volvulus from a diaphragmatic hernia after left splenopancreatectomy: Report of a case.
  • A delay in diagnosis and treatment can result in fatal complications such as gastric ischemia, perforation, and hemorrhage.
  • We report a case of intrathoracic localization of an acute and incarcerated organoaxial gastric volvulus caused by a left-sided diaphragmatic hernia resulting from a diaphragmatic injury.
  • The patient had undergone a left splenopancreatectomy 4 years earlier for non-Hodgkin's lymphoma.
  • We performed an emergency left thoracotomy with reduction of the acute volvulus, resection of the adhesions, and exeresis of an inflammatory mass from the omentum, with good results.
  • [MeSH-minor] Endoscopy, Gastrointestinal. Humans. Lymphoma, Non-Hodgkin / surgery. Male. Middle Aged. Postoperative Complications. Thoracotomy / methods. Tomography, X-Ray Computed

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  • (PMID = 17072719.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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40. Muszynska-Roslan K, Konstantynowicz J, Panasiuk A, Krawczuk-Rybak M: Is the treatment for childhood solid tumors associated with lower bone mass than that for leukemia and Hodgkin disease? Pediatr Hematol Oncol; 2009 Jan;26(1):36-47
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  • PROCEDURES: To identify factors associated with reduced bone mineral density (BMD) in survivors of childhood cancer the authors examined 114 patients (70 males) who had been treated for acute lymphoblastic leukemia (ALL; n = 43), Hodgkin disease (HD; n = 35), and solid tumors (ST; n = 36) twice.
  • Median age at diagnosis was 8.4 years; at the consecutive examinations it was 12.8 and 16.3 years, respectively.
  • [MeSH-major] Antineoplastic Agents / adverse effects. Bone Density / drug effects. Hodgkin Disease / physiopathology. Neoplasms / physiopathology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / physiopathology

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  • (PMID = 19206007.001).
  • [ISSN] 1521-0669
  • [Journal-full-title] Pediatric hematology and oncology
  • [ISO-abbreviation] Pediatr Hematol Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Steroids
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41. Colella G, Tirelli A, Capone R, Rubini C, Guastafierro S: Myeloid sarcoma occurring in the maxillary gingiva: a case without leukemic manifestations. Int J Hematol; 2005 Feb;81(2):138-41
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  • Myeloid sarcoma (MS) is a localized extramedullary mass of immature granulocytic cells that usually occurs in patients with acute myeloid leukemia (AML) or myeloproliferative disorders.
  • The histologic specimen was first interpreted as non-Hodgkin's lymphoma.
  • The correct diagnosis was reached after extensive immunohistologic studies.
  • The present case indicates the importance of a correct initial diagnosis for adequate therapy, which is often delayed because of a high misdiagnosis rate.

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  • (PMID = 15765782.001).
  • [ISSN] 0925-5710
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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42. Pradeep R, Madhumathi DS, Lakshmidevi V, Premalata CS, Appaji L, Patil SA, Swapnil B: Bilateral nephromegaly simulating wilms tumor: a rare initial manifestation of acute lymphoblastic leukemia. J Pediatr Hematol Oncol; 2008 Jun;30(6):471-3
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  • [Title] Bilateral nephromegaly simulating wilms tumor: a rare initial manifestation of acute lymphoblastic leukemia.
  • A 7-year-old boy was referred with a provisional diagnosis of bilateral Wilms tumor.
  • Immunohistochemistry on paraffin sections showed a pre-B phenotype of acute lymphoblastic leukemia.
  • Finally, a diagnosis of pre-B acute lymphoblastic leukemia infiltrating both the kidneys was made.
  • [MeSH-major] Kidney Diseases / etiology. Kidney Neoplasms / pathology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications. Wilms Tumor / pathology
  • [MeSH-minor] Biopsy, Fine-Needle. Child. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Tomography, X-Ray Computed


43. Tageja N, Valent J, Bentley G, Zonder J: Precursor T cell acute lymphoblastic lymphoma presenting as bilateral facial nerve palsy. Chemotherapy; 2010;56(3):258-60
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  • [Title] Precursor T cell acute lymphoblastic lymphoma presenting as bilateral facial nerve palsy.
  • [MeSH-major] Facial Nerve Diseases / diagnosis. Facial Paralysis / diagnosis. Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Stem Cells / pathology

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  • (PMID = 20551643.001).
  • [ISSN] 1421-9794
  • [Journal-full-title] Chemotherapy
  • [ISO-abbreviation] Chemotherapy
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Switzerland
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44. De Braekeleer E, Douet-Guilbert N, Morel F, Le Bris MJ, Basinko A, Berthou C, Morice P, Férec C, De Braekeleer M: Philadelphia chromosome-positive acute lymphoblastic leukemia: a cytogenetic study of 33 patients diagnosed between 1981 and 2008. Anticancer Res; 2010 Feb;30(2):569-73
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  • [Title] Philadelphia chromosome-positive acute lymphoblastic leukemia: a cytogenetic study of 33 patients diagnosed between 1981 and 2008.
  • BACKGROUND: The Philadelphia (Ph) chromosome, resulting from a t(9;22)(q34;q11), is one of the most frequent chromosomal abnormalities observed among patients with acute lymphoblastic leukemia (ALL).
  • PATIENTS AND METHODS: Conventional cytogenetic analysis was performed on bone marrow cells at the time of diagnosis and/or relapse of 208 patients shown to have B-cell ALL.
  • [MeSH-major] Fusion Proteins, bcr-abl / genetics. Leukemia, B-Cell / diagnosis. Leukemia, B-Cell / genetics. Philadelphia Chromosome. Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics

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  • (PMID = 20332472.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] EC 2.7.10.2 / Fusion Proteins, bcr-abl
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45. Grand S, Lefournier V, Krainik A, Bessou P, Tropres I, Chabardes S, Hoffmann D, Le Bas JF: [MR and CT perfusion imaging of the brain: principles and clinical applications]. J Radiol; 2007 Mar;88(3 Pt 2):444-71
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  • MR and recently CT perfusion have substantially modified the treatment of acute stroke.
  • Both are also helpful for the diagnosis of brain tumors and the assessment of treatment effects.
  • [MeSH-major] Brain Diseases / diagnosis. Brain Diseases / radiography. Magnetic Resonance Imaging / methods. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Acute Disease. Adult. Aged. Astrocytoma / diagnosis. Astrocytoma / radiography. Brain Abscess / diagnosis. Brain Abscess / radiography. Brain Ischemia / diagnosis. Brain Ischemia / radiography. Brain Neoplasms / diagnosis. Brain Neoplasms / radiography. Cerebral Hemorrhage / diagnosis. Cerebral Hemorrhage / radiography. Cerebrovascular Disorders / diagnosis. Cerebrovascular Disorders / radiography. Child, Preschool. Female. Follow-Up Studies. Gadolinium. Glioma / diagnosis. Glioma / radiography. Humans. Lymphoma / diagnosis. Lymphoma / radiography. Male. Melanoma / diagnosis. Melanoma / radiography. Meningeal Neoplasms / diagnosis. Meningeal Neoplasms / radiography. Meningioma / diagnosis. Meningioma / radiography. Middle Aged. Oligodendroglioma / diagnosis. Oligodendroglioma / radiography. Perfusion

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  • (PMID = 17457257.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] AU0V1LM3JT / Gadolinium
  • [Number-of-references] 34
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46. Stewart AK, Bergsagel PL, Greipp PR, Dispenzieri A, Gertz MA, Hayman SR, Kumar S, Lacy MQ, Lust JA, Russell SJ, Witzig TE, Zeldenrust SR, Dingli D, Reeder CB, Roy V, Kyle RA, Rajkumar SV, Fonseca R: A practical guide to defining high-risk myeloma for clinical trials, patient counseling and choice of therapy. Leukemia; 2007 Mar;21(3):529-34
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  • Indeed, as in acute leukemias and non-hodgkins lymphoma, we believe it is no longer acceptable to consider MM a single disease entity.
  • As such, the accurate diagnosis of MM subtypes and the adoption of common criteria for the identification and stratification of MM patients has become critical.

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  • (PMID = 17230230.001).
  • [ISSN] 0887-6924
  • [Journal-full-title] Leukemia
  • [ISO-abbreviation] Leukemia
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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47. Candoni A, Michelutti A, Simeone E, Damiani D, Baccarani M, Fanin R: Efficacy of liposomal daunorubicin and cytarabine as reinduction chemotherapy in relapsed acute lymphoblastic leukaemia despite expression of multidrug resistance-related proteins. Eur J Haematol; 2006 Oct;77(4):293-9
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  • [Title] Efficacy of liposomal daunorubicin and cytarabine as reinduction chemotherapy in relapsed acute lymphoblastic leukaemia despite expression of multidrug resistance-related proteins.
  • The treatment of relapsed adult acute lymphoblastic leukaemia (ALL) is frequently unsuccessful with current chemotherapy regimens, and often there is an overexpression of multidrug resistance (MDR)-related proteins.
  • Before the start of DNX therapy, 18/25 (72%) cases overexpressed at least one MDR-related protein compared with 9/25 (36%) cases with MDR overexpression at diagnosis (P = 0.01).
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Multidrug Resistance-Associated Proteins / metabolism. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy

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  • (PMID = 16856922.001).
  • [ISSN] 0902-4441
  • [Journal-full-title] European journal of haematology
  • [ISO-abbreviation] Eur. J. Haematol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Liposomes; 0 / Multidrug Resistance-Associated Proteins; 04079A1RDZ / Cytarabine; ZS7284E0ZP / Daunorubicin
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48. Parovichnikova EN, Savchenko VG, Verniuk MA, Vinogradova OA, Misiurin AV, Vorob'ev IA, Domracheva EV, Tikhonova LIu, Rukavitsyn OA, Rossiev VA, Kliasova GA, Turkina AG, Liubimova LS, Mendeleeva LP, Isaev VG: [Acute lymphoblastic leukemias with aberrations of BCR-ABL genes]. Ter Arkh; 2005;77(7):11-6
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  • [Title] [Acute lymphoblastic leukemias with aberrations of BCR-ABL genes].
  • AIM: To develop an original therapeutic strategy in Ph-positive acute lymphoblastic leukemia (ALL).
  • The diagnosis of Ph-positive ALL was established in detection of translocation t(9;22) by standard cytogenetic test or fluorescent hibridization in situ with double signal (D-FISH), or by polymerase chain reaction with reverse transcription (RT-PCR).
  • [MeSH-major] Fusion Proteins, bcr-abl / genetics. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics

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  • (PMID = 16116902.001).
  • [ISSN] 0040-3660
  • [Journal-full-title] Terapevticheskiĭ arkhiv
  • [ISO-abbreviation] Ter. Arkh.
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.2 / Fusion Proteins, bcr-abl
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49. Dasgupta N, Gelber AC, Racke F, Fine DM: Central nervous system lymphoma associated with mycophenolate mofetil in lupus nephritis. Lupus; 2005;14(11):910-3
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  • [Title] Central nervous system lymphoma associated with mycophenolate mofetil in lupus nephritis.
  • We describe a 58-year old Korean woman with SLE who presented with acute headache and confusion in the setting of prednisone and mycophenolate mofetil (MMF) therapy used to treat focal proliferative and membranous lupus nephritis.
  • A brain biopsy revealed an Epstein-Barr virus (EBV)-positive diffuse large B cell lymphoma.
  • This is the first description of CNS lymphoma in a patient treated with MMF for lupus nephritis.
  • While intracerebral lymphoma in the immunocompromised patient with lupus is rare, this disorder should be considered in the differential diagnosis of new-onset neurological symptoms among such patients.
  • [MeSH-major] Brain Neoplasms / etiology. Immunosuppressive Agents / administration & dosage. Lupus Nephritis / drug therapy. Lymphoma, B-Cell / etiology. Mycophenolic Acid / analogs & derivatives

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  • (PMID = 16335585.001).
  • [ISSN] 0961-2033
  • [Journal-full-title] Lupus
  • [ISO-abbreviation] Lupus
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; HU9DX48N0T / Mycophenolic Acid
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50. Ortín X, Rodríguez-Luaces M, Bosch R, Lejeune M, Font L: Acute liver failure as the first manifestation of very late relapsing of Hodgkin's disease. Hematol Rep; 2010 Jan 26;2(1):e5
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  • [Title] Acute liver failure as the first manifestation of very late relapsing of Hodgkin's disease.
  • There have been sporadic case reports of acute liver failure caused by hematological malignancies.
  • Generally, liver failure is a feature of stage IV end-stage disease, when it occurs in lymphoma.
  • Thus, hepatic involvement usually occurs late in the course of Hodgkin's disease or with advanced-stage disease, and primary presentation in the liver with acute liver failure is extremely rare.
  • In most cases, the diagnosis was made at autopsy.
  • We describe a patient with Hodgkin's disease presenting with acute liver failure.
  • This is a very unusual Hodgkin's disease form of presentation, because the acute liver failure was the presenting feature of the disease.
  • Furthermore, the lymphoma occurred as a very late relapse, twenty years after the first diagnosis.

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  • (PMID = 22184518.001).
  • [ISSN] 2038-8330
  • [Journal-full-title] Hematology reports
  • [ISO-abbreviation] Hematol Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC3222269
  • [Keywords] NOTNLM ; Hodgkin's disease. / acute liver failure
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51. Hagedorn N, Acquaviva C, Fronkova E, von Stackelberg A, Barth A, zur Stadt U, Schrauder A, Trka J, Gaspar N, Seeger K, Henze G, Cavé H, Eckert C, Resistant Disease Committee of the International BFM study group: Submicroscopic bone marrow involvement in isolated extramedullary relapses in childhood acute lymphoblastic leukemia: a more precise definition of "isolated" and its possible clinical implications, a collaborative study of the Resistant Disease Committee of the International BFM study group. Blood; 2007 Dec 1;110(12):4022-9
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  • [Title] Submicroscopic bone marrow involvement in isolated extramedullary relapses in childhood acute lymphoblastic leukemia: a more precise definition of "isolated" and its possible clinical implications, a collaborative study of the Resistant Disease Committee of the International BFM study group.
  • This study investigates the extent of bone marrow (BM) involvement at diagnosis of apparent isolated extramedullary (AIEM) relapses of childhood acute lymphoblastic leukemia (ALL) and its relation to prognosis.
  • In summary, we show marked heterogeneity of submicroscopic BM involvement at first AIEM relapse diagnosis in children with ALL, and demonstrate its possible prognostic relevance.
  • [MeSH-major] Bone Marrow. Gene Rearrangement, B-Lymphocyte / genetics. Polymerase Chain Reaction. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics. Receptors, Antigen, T-Cell / genetics


52. Gopal M, Fisher R: A case report of B-cell lymphoma masquerading as superior mesenteric artery syndrome. J Pediatr Surg; 2007 Nov;42(11):1926-7
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  • [Title] A case report of B-cell lymphoma masquerading as superior mesenteric artery syndrome.
  • We report the case of a child, who after an episode of acute weight loss presented with features suggestive of SMA syndrome.
  • This child subsequently was shown at operation to have disseminated lymphoma causing a secondary high jejunal intussusception and tumor involvement of retroperitoneal lymph nodes causing compression of the third part of the duodenum.
  • This case emphasizes that the SMA syndrome should be considered a sign rather than a diagnosis in itself.
  • [MeSH-major] Intestinal Obstruction / diagnosis. Intussusception / diagnosis. Jejunal Diseases / diagnosis. Lymphoma, B-Cell / diagnosis. Superior Mesenteric Artery Syndrome / diagnosis
  • [MeSH-minor] Anastomosis, Surgical. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Diagnosis, Differential. Digestive System Surgical Procedures / methods. Female. Follow-Up Studies. Humans. Laparotomy / methods. Treatment Outcome


53. Asgarian Omran H, Shabani M, Vossough P, Sharifian R, Tabrizi M, Khoshnoodi J, Jeddi-Tehrani M, Rabbani H, Shokri F: Cross-sectional monitoring of Wilms' tumor gene 1 (WT1) expression in Iranian patients with acute lymphoblastic leukemia at diagnosis, relapse and remission. Leuk Lymphoma; 2008 Feb;49(2):281-90
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  • [Title] Cross-sectional monitoring of Wilms' tumor gene 1 (WT1) expression in Iranian patients with acute lymphoblastic leukemia at diagnosis, relapse and remission.
  • High WT1 mRNA expression has been detected in the majority of acute leukemias and has been identified as a convenient marker for disease monitoring.
  • The aim of this study was to evaluate WT1 expression in Iranian ALL patients at diagnosis, relapse and remission.
  • WT1 mRNA was detected in leukemic cells of ALL patients obtained at diagnosis (n = 62), relapse (n = 19) and remission (n = 35) using a semi-quantitative RT-PCR method.
  • [MeSH-major] Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis. RNA, Messenger / blood. WT1 Proteins / genetics

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  • [ErratumIn] Leuk Lymphoma. 2008 Mar;49(3):598. Omran, Hossein [corrected to Asgarian Omran, Hossein]
  • (PMID = 18231915.001).
  • [ISSN] 1029-2403
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA, Messenger; 0 / WT1 Proteins
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54. Shin HJ, Chung JS, Cho GJ: Imatinib interim therapy between chemotherapeutic cycles and in vivo purging prior to autologous stem cell transplantation, followed by maintenance therapy is a feasible treatment strategy in Philadelphia chromosome-positive acute lymphoblastic leukemia. Bone Marrow Transplant; 2005 Nov;36(10):917-8
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  • [Title] Imatinib interim therapy between chemotherapeutic cycles and in vivo purging prior to autologous stem cell transplantation, followed by maintenance therapy is a feasible treatment strategy in Philadelphia chromosome-positive acute lymphoblastic leukemia.
  • [MeSH-major] Bone Marrow Purging / methods. Hematopoietic Stem Cell Transplantation / methods. Piperazines / therapeutic use. Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy. Pyrimidines / therapeutic use
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Benzamides. Female. Humans. Imatinib Mesylate. Neoplasm, Residual / diagnosis. Neoplasm, Residual / drug therapy. Transplantation, Autologous

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  • (PMID = 16113662.001).
  • [ISSN] 0268-3369
  • [Journal-full-title] Bone marrow transplantation
  • [ISO-abbreviation] Bone Marrow Transplant.
  • [Language] eng
  • [Publication-type] Clinical Trial; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
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55. Miller JS, Lee TK, Epstein JI, Ulbright TM: The utility of microscopic findings and immunohistochemistry in the classification of necrotic testicular tumors: a study of 11 cases. Am J Surg Pathol; 2009 Sep;33(9):1293-8
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  • Because of differing treatments for seminomas versus nonseminomas, accurate diagnosis is critical.
  • The submitting pathologists favored benign processes in 4 cases, Leydig cell tumor in 1, and lymphoma in 1.
  • All patients presented with unilateral testicular masses (6 right, 5 left); 2 also had acute pain.

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  • (PMID = 19461507.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD30; 0 / Biomarkers, Tumor; 0 / Octamer Transcription Factor-3; 0 / POU5F1 protein, human; 0 / alpha-Fetoproteins; 68238-35-7 / Keratins; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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56. Dilek I, Ayakta H, Demir C, Meral C, Ozturk M: CA 125 levels in patients with non-Hodgkin lymphoma and other hematologic malignancies. Clin Lab Haematol; 2005 Feb;27(1):51-5
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  • [Title] CA 125 levels in patients with non-Hodgkin lymphoma and other hematologic malignancies.
  • The study group included 69 non-Hodgkin lymphomas (NHL), 25 Hodgkin disease (HD), 20 acute myelocytic leukemia (AML), 14 chronic lymphocytic leukemia (CLL), 12 chronic myelocytic leukemia (CML), and nine multiple myeloma (MM) patients.
  • [MeSH-major] CA-125 Antigen / blood. Hematologic Neoplasms / blood. Hematologic Neoplasms / diagnosis. Lymphoma, Non-Hodgkin / blood. Lymphoma, Non-Hodgkin / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Leukemia / blood. Leukemia / classification. Leukemia / diagnosis. Male. Middle Aged

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  • (PMID = 15686508.001).
  • [ISSN] 0141-9854
  • [Journal-full-title] Clinical and laboratory haematology
  • [ISO-abbreviation] Clin Lab Haematol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CA-125 Antigen
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57. Nakase K, Tsuji K, Tamaki S, Tanigawa M, Ikeda T, Miyanishi E, Shiku H: Elevated levels of soluble interleukin-2 receptor in serum of patients with hematological or non-hematological malignancies. Cancer Detect Prev; 2005;29(3):256-9
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  • We measured the levels of soluble interleukin-2 receptor (sIL-2R) in the serum of 53 patients with hematological malignancies (14 with acute leukemia, 10 myeloproliferative disorders, 21 non-Hodgkin's lymphoma and 8 multiple myeloma), 40 with non-hematological solid malignancies (24 with lung cancer, 11 digestive system cancer and 5 other cancers) and 95 healthy subjects as a control using an enzyme-linked immunosorbent assay.
  • These results seem to suggest that sIL-2R levels may serve as one of non-invasive markers of differential diagnosis for patients with bulky mass lesions between hematological and solid malignancy.
  • [MeSH-major] Biomarkers, Tumor / blood. Hematologic Neoplasms / diagnosis. Hematologic Neoplasms / pathology. Receptors, Interleukin-2 / blood
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Case-Control Studies. Diagnosis, Differential. Enzyme-Linked Immunosorbent Assay. Female. Humans. Male. Middle Aged

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  • (PMID = 15899555.001).
  • [ISSN] 0361-090X
  • [Journal-full-title] Cancer detection and prevention
  • [ISO-abbreviation] Cancer Detect. Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptors, Interleukin-2
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58. Gao C, Li ZG, Zhao W, Wu MY: [Correlation of E2a-pbx1 expression level with clinical characteristics and early response to treatment in children with acute lymphoblastic leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2008 Jun;16(3):569-73
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  • [Title] [Correlation of E2a-pbx1 expression level with clinical characteristics and early response to treatment in children with acute lymphoblastic leukemia].
  • This study purposed to investigate the correlation of expression level of e2a-pbx1 (immunoglobulin enhancer binding factor-Pre-B leukemia) with clinical characteristics and early response to treatment in children patients with acute lymphoblastic leukemia (ALL).
  • The expression level of e2a-pbx1 at primary diagnosis in 45 children with ALL, and on day 33 after induction of remission in 23 children with ALL were detected by real-time quantitative polymerase chain reaction (RQ-PCR).
  • The corelation of e2a-pbx1 expression level at primary diagnosis, MRD level with clinical characteristics and early response to treatment were all observed and explored.
  • The expression level of e2a-pbx1 and clinical characteristics at primary diagnosis were compared between MRD negative and MRD positive patients.
  • The results showed that the expression level of e2a-pbx1 was correlated with the blast percentage in peripheral blood at primary diagnosis.
  • The MRD level at day 33 after induction of remission in 23 children were not related to the expression level of e2a-pbx1 at primary diagnosis and the clinical characteristics.
  • The expression level of e2a-pbx1 at primary diagnosis in MRD positive patients was higher than that in MRD negative patients, while their age was significantly lower than that of patients with MRD negative.
  • The blast percentage in peripheral blood at diagnosis of patients with presenting leukocyte count < 25 x 10(9)/L was significantly lower than that of patients with presenting leukocyte count >or= 25 x 10(9)/L, while the platelet count was higher.
  • It is concluded that the expression level of e2a-pbx1 at primary diagnosis indicates the load of tumor in patients.
  • In patients whose MRD were positive, the expression level of e2a-pbx1 at primary diagnosis is high and their age is young.
  • The platelet count is low in the patients with high load of tumor at primary diagnosis.

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  • (PMID = 18549631.001).
  • [ISSN] 1009-2137
  • [Journal-full-title] Zhongguo shi yan xue ye xue za zhi
  • [ISO-abbreviation] Zhongguo Shi Yan Xue Ye Xue Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / Oncogene Proteins, Fusion; 146150-85-8 / E2A-Pbx1 fusion protein
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59. Stark B, Avigad S, Luria D, Manor S, Reshef-Ronen T, Avrahami G, Yaniv I: Bone marrow minimal disseminated disease (MDD) and minimal residual disease (MRD) in childhood T-cell lymphoblastic lymphoma stage III, detected by flow cytometry (FC) and real-time quantitative polymerase chain reaction (RQ-PCR). Pediatr Blood Cancer; 2009 Jan;52(1):20-5
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  • [Title] Bone marrow minimal disseminated disease (MDD) and minimal residual disease (MRD) in childhood T-cell lymphoblastic lymphoma stage III, detected by flow cytometry (FC) and real-time quantitative polymerase chain reaction (RQ-PCR).
  • BACKGROUND: Despite overlapping features of T-cell lymphoblastic lymphoma (T-LLy) and T-cell acute lymphoblastic leukemia (T-ALL), which respond favorably to T-ALL treatment, clinical and biological differences exist.
  • We retrospectively assessed the prevalence of submicroscopic bone marrow (BM) minimal disseminated disease (MDD) at diagnosis and the early response to treatment (minimal residual disease--MRD) and their prognostic significance in 17 children with stage III T-LLy treated according to Berlin-Frankfurt-Munster (BFM) non-Hodgkin lymphoma protocols.
  • PROCEDURE: Four-color flow cytometry (FC) was used for lymphoma associated immunophenotype and real-time quantitative polymerase chain reaction (RQ-PCR) for T-cell receptor (TCR beta/delta/gamma) gene rearrangements with at least 0.01% sensitivity.
  • BM MDD at diagnosis of >or=0.01% was detected by FC and RQ-PCR in 88% and 80% of patients, respectively, and by at least one of the methods in all patients.
  • [MeSH-major] Bone Marrow Diseases / diagnosis. Neoplasm, Residual / diagnosis. Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / diagnosis

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  • (PMID = 19006253.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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60. Kunsdorf-Wnuk A, Marzec-Lewenstein E, Arct-Danielak D, Musioł E, Bohatyrewicz R, Becht R: The use of recombinant human activated protein C (rhAPC) in the treatment of severe sepsis in immunosuppressed patients in the course of hematological diseases. Med Sci Monit; 2005 Aug;11(8):CS49-55
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  • We present two cases of treating severe sepsis utilizing recombinant human activated protein C (rhAPC) in the course of bilateral pneumonia in patients with hairy cell leukemia (HCL) and T-cell acute lymphoblastic leukemia (ALL).
  • CONCLUSIONS: Patient survival in severe sepsis directly depends on early diagnosis and institution of treatment.
  • [MeSH-major] Immune Tolerance. Leukemia, Hairy Cell / complications. Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications. Protein C / therapeutic use. Sepsis / complications. Sepsis / drug therapy

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  • (PMID = 16049385.001).
  • [ISSN] 1234-1010
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Protein C; 0 / Recombinant Proteins
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61. Stabell N, Nordal E, Stensvold E, Gammelsrud KW, Lund B, Taxt A, Buhring F, Greve-Isdahl M, Fornebo HP, Simonsen GS, Klingenberg C: Febrile neutropenia in children with cancer: a retrospective Norwegian multicentre study of clinical and microbiological outcome. Scand J Infect Dis; 2008;40(4):301-7
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  • Acute lymphoblastic leukaemia was the most common diagnosis (49 patients).
  • [MeSH-minor] Anti-Bacterial Agents / therapeutic use. Antineoplastic Agents / adverse effects. Antineoplastic Agents / therapeutic use. Bacterial Infections / drug therapy. Bacterial Infections / microbiology. Child. Child, Preschool. Female. Gram-Negative Bacteria / drug effects. Gram-Positive Bacteria / drug effects. Humans. Incidence. Male. Norway / epidemiology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Precursor Cell Lymphoblastic Leukemia-Lymphoma / epidemiology. Prognosis. Treatment Outcome

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  • (PMID = 17918015.001).
  • [ISSN] 0036-5548
  • [Journal-full-title] Scandinavian journal of infectious diseases
  • [ISO-abbreviation] Scand. J. Infect. Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Antineoplastic Agents
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62. Smith HA, Fuchs DC, Pandharipande PP, Barr FE, Ely EW: Delirium: an emerging frontier in the management of critically ill children. Crit Care Clin; 2009 Jul;25(3):593-614, x
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  • The objectives of this article are (1) to introduce pediatric delirium and provide understanding of acute brain dysfunction with its classification and clinical presentations (2) to understand how delirium is diagnosed and discuss current modes of delirium diagnosis in the critically ill adult population and translation to pediatrics (3) to understand the prevalence and prognostic significance of delirium in the adult and pediatric critically ill population (4) to discuss the pathophysiology of delirium as currently understood, and (5) to provide general management guidelines for delirium.

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  • (PMID = 19576533.001).
  • [ISSN] 1557-8232
  • [Journal-full-title] Critical care clinics
  • [ISO-abbreviation] Crit Care Clin
  • [Language] ENG
  • [Grant] United States / NIA NIH HHS / AG / AG001023-01A1; United States / NIA NIH HHS / AG / K23 AG001023; United States / NIA NIH HHS / AG / AG001023; United States / NIA NIH HHS / AG / K23 AG001023-01A1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] United States
  • [Number-of-references] 143
  • [Other-IDs] NLM/ NIHMS135370; NLM/ PMC2793079
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63. Kaste SC, Thomas NA, Rai SN, Cheon K, McCammon E, Chesney R, Jones D, Pui CH, Hudson MM: Asymptomatic kidney stones in long-term survivors of childhood acute lymphoblastic leukemia. Leukemia; 2009 Jan;23(1):104-8
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  • [Title] Asymptomatic kidney stones in long-term survivors of childhood acute lymphoblastic leukemia.
  • We hypothesized an association between renal calculi and bone mineral density (BMD) deficits, shown in adults, exists in survivors of childhood acute lymphoblastic leukemia (ALL).
  • Thus, we analyzed the associations between quantitative computed tomography (QCT)-determined renal calcifications and clinical parameters (gender, race, age at diagnosis and age at the time of QCT), BMD, treatment exposures and Tanner stage.
  • Most (n=270; 63.7%) were >or=3.5 years at ALL diagnosis.


64. Medeiros BC, Minden MD, Schuh AC, Schimmer AD, Yee K, Lipton JH, Messner HA, Gupta V, Chun K, Xu W, Das P, Kamel-Reid S, Brandwein JM: Characteristics and outcomes of acute myelogenous leukemia patients with very late relapse (&gt;5 years). Leuk Lymphoma; 2007 Jan;48(1):65-71
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  • [Title] Characteristics and outcomes of acute myelogenous leukemia patients with very late relapse (>5 years).
  • The clinical characteristics and outcome of 15 patients with acute myelogenous leukemia (AML) who experienced relapse at least 5 years after induction of complete remission (very late-relapse AML) are described.
  • There were eight males in this cohort and the median age at diagnosis was 48 years (range 13 - 77 years).
  • [MeSH-major] Leukemia, Myeloid, Acute / diagnosis


65. Wills BS: Coping with a child with acute lymphocytic leukemia: the experiences of Chinese fathers in Hong Kong. Cancer Nurs; 2009 Mar-Apr;32(2):E8-E14
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  • [Title] Coping with a child with acute lymphocytic leukemia: the experiences of Chinese fathers in Hong Kong.
  • Using a qualitative approach, this article aims to describe the experiences of Hong Kong Chinese fathers whose children were diagnosed with acute lymphocytic leukemia.
  • Two in-depth interviews scheduled to coincide with the disease trajectory of acute lymphocytic leukemia were conducted with 9 fathers, and data were analyzed using the matrix system described by Miles and Huberman.
  • Four categories were identified, including fathers' initial reactions to the child's confirmed diagnosis, the decision to disclose the child's diagnosis to others, social support of the fathers, and their effective coping mechanisms.
  • Findings from this study indicate that Hong Kong Chinese fathers need emotional support especially at the onset of the child's diagnosis.
  • [MeSH-major] Adaptation, Psychological. Fathers / psychology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / psychology

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  • (PMID = 19125122.001).
  • [ISSN] 1538-9804
  • [Journal-full-title] Cancer nursing
  • [ISO-abbreviation] Cancer Nurs
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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66. Fukushima T, Miyazaki Y, Honda S, Kawano F, Moriuchi Y, Masuda M, Tanosaki R, Utsunomiya A, Uike N, Yoshida S, Okamura J, Tomonaga M: Allogeneic hematopoietic stem cell transplantation provides sustained long-term survival for patients with adult T-cell leukemia/lymphoma. Leukemia; 2005 May;19(5):829-34
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  • [Title] Allogeneic hematopoietic stem cell transplantation provides sustained long-term survival for patients with adult T-cell leukemia/lymphoma.
  • Adult T-cell leukemia/lymphoma (ATLL) is a distinct peripheral T-cell neoplasm that is highly resistant to chemotherapy.
  • To confirm our previous report and to establish the basis for a phase II clinical study, we analyzed 40 allo-HSCT for acute and lymphoma types of ATLL in seven institutions in Japan between 1997 and 2002.
  • [MeSH-major] Hematopoietic Stem Cell Transplantation / adverse effects. Leukemia-Lymphoma, Adult T-Cell / therapy

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  • (PMID = 15744352.001).
  • [ISSN] 0887-6924
  • [Journal-full-title] Leukemia
  • [ISO-abbreviation] Leukemia
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
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67. Tektonidou MG, Skopouli FN: Visceral leishmaniasis in a patient with psoriatic arthritis treated with infliximab: reactivation of a latent infection? Clin Rheumatol; 2008 Apr;27(4):541-2
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  • We report the case of a 45-year-old man with psoriatic arthritis, receiving treatment with infliximab, who presented with high-grade fever, rigor, splenomegaly, acute reactive proteins, and pancytopenia.
  • The diagnosis of visceral leishmaniasis was established.
  • [MeSH-major] Antibodies, Monoclonal / adverse effects. Antirheumatic Agents / adverse effects. Arthritis, Psoriatic / drug therapy. Leishmaniasis, Visceral / diagnosis. Opportunistic Infections / diagnosis


68. Agnani S, Gupta R, Atray NK, Vachharajani TJ: Marked hyperuricemia with acute renal failure: need to consider occult malignancy and spontaneous tumour lysis syndrome. Int J Clin Pract; 2006 Mar;60(3):364-6
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  • [Title] Marked hyperuricemia with acute renal failure: need to consider occult malignancy and spontaneous tumour lysis syndrome.
  • Spontaneous tumour lysis syndrome (TLS) is an extremely uncommon cause for acute renal failure (ARF).
  • We describe two cases of lymphoma presenting with ARF secondary to spontaneous TLS.
  • The ARF in the first case appeared to be due to intravenous volume depletion but eventually lead to the diagnosis of gastric lymphoma.
  • The second patient is interesting as he is probably the first reported case of lymphoma with HIV infection presenting as spontaneous TLS.
  • Early diagnosis and prompt renal replacement therapy does not necessarily reverse the ARF.
  • [MeSH-major] Acute Kidney Injury / etiology. Hyperuricemia / etiology. Tumor Lysis Syndrome / etiology
  • [MeSH-minor] Aged. HIV Seropositivity / complications. Humans. Lymphoma, B-Cell / complications. Lymphoma, Large B-Cell, Diffuse / complications. Male. Middle Aged. Renal Dialysis. Skin Neoplasms / complications. Stomach Neoplasms / complications

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  • (PMID = 16494656.001).
  • [ISSN] 1368-5031
  • [Journal-full-title] International journal of clinical practice
  • [ISO-abbreviation] Int. J. Clin. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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69. Roongpoovapatr P, Suankratay C: Causative pathogens of fever in neutropenic patients at King Chulalongkorn Memorial Hospital. J Med Assoc Thai; 2010 Jul;93(7):776-83
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  • The three most common primary diseases associated with neutropenia were acute myeloid leukemia, non-Hodgkin's lymphoma, and acute lymphoblastic leukemia (36.6%, 33.1%, and 10.5%).

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  • (PMID = 20649055.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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70. Gadó J, Schlick B, Bárány O, Németh J, Müller J, Csóka M, Constantin T, Vonnák E, Böcskei R, Hauser P, Kovács G: [The function of the immune system after the treatment of pediatric malignant diseases]. Orv Hetil; 2006 Sep 10;147(36):1731-8
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  • PATIENTS: 88 long-term survivors (51 boys, 37 girls) were investigated (43 acute lymphoid leukemia, 15 lymphoma, 20 bone tumors, 10 other solid tumors).
  • Mean age at the time of diagnosis was 7.8 years (1 mo-17.7 years).

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  • (PMID = 17087017.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Immunoglobulin A; 0 / Immunoglobulin G; 0 / Immunoglobulin M
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71. Bien E, Maciejka-Kapuscinska L, Niedzwiecki M, Stefanowicz J, Szolkiewicz A, Krawczyk M, Maldyk J, Izycka-Swieszewska E, Tokarska B, Balcerska A: Childhood rhabdomyosarcoma metastatic to bone marrow presenting with disseminated intravascular coagulation and acute tumour lysis syndrome: review of the literature apropos of two cases. Clin Exp Metastasis; 2010 Aug;27(6):399-407
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  • [Title] Childhood rhabdomyosarcoma metastatic to bone marrow presenting with disseminated intravascular coagulation and acute tumour lysis syndrome: review of the literature apropos of two cases.
  • The paper presents diagnostic and therapeutic difficulties in two adolescents with widespread rhabdomyosarcoma (RMS) presenting with severe haemorrhages resulting from disseminated intravascular coagulation (DIC) and with laboratory features of acute tumour lysis syndrome (ATLS).
  • It has been concluded that the clinical picture of a widespread RMS in children may resemble acute hematologic malignancy and pose a big diagnostic problem.
  • That is why the presence of small blue round cells morphologically similar to lymphoblasts and/or myeloblasts in bone marrow (BM), lacking hematopoietic makers, should prompt the pathologist to consider possible diagnosis of RMS.
  • When the representative histopathological tumour specimens are difficult to obtain, the flow cytometric immunophenotyping of BM metastases could help the standard morphological/immunohistological diagnostic procedures and advance the diagnosis.
  • [MeSH-minor] Acute Disease. Adolescent. Female. Humans. Male. Prognosis

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  • (PMID = 20517638.001).
  • [ISSN] 1573-7276
  • [Journal-full-title] Clinical & experimental metastasis
  • [ISO-abbreviation] Clin. Exp. Metastasis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 44
  • [Other-IDs] NLM/ PMC2910884
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72. Gurney JG, Ness KK, Sibley SD, O'Leary M, Dengel DR, Lee JM, Youngren NM, Glasser SP, Baker KS: Metabolic syndrome and growth hormone deficiency in adult survivors of childhood acute lymphoblastic leukemia. Cancer; 2006 Sep 15;107(6):1303-12
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  • [Title] Metabolic syndrome and growth hormone deficiency in adult survivors of childhood acute lymphoblastic leukemia.
  • BACKGROUND: The purpose of the study was to determine the prevalence of metabolic syndrome, growth hormone deficiency, and cardiovascular risk factors among adult survivors of childhood acute lymphoblastic leukemia (ALL) treated with or without cranial irradiation.
  • RESULTS: The mean subject age was 30 years and the mean time since ALL diagnosis was 25 years.
  • [MeSH-major] Cranial Irradiation / adverse effects. Growth Hormone / deficiency. Metabolic Syndrome X / blood. Precursor Cell Lymphoblastic Leukemia-Lymphoma / radiotherapy


73. Lad EM, Jain A, Lad SP, Lin RC, Alcorn DM, Moshfeghi DM: Orbital recurrence of B-progenitor acute lymphoblastic leukemia in a child. J Pediatr Ophthalmol Strabismus; 2010 Jan-Feb;47(1):46-50
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  • [Title] Orbital recurrence of B-progenitor acute lymphoblastic leukemia in a child.
  • Orbital mass is an exceedingly rare presentation of acute lymphoblastic leukemia.
  • This report describes a 12-year-old boy with recurrent orbital pre-B-cell acute lymphoblastic leukemia and reviews the literature on the incidence, presentation, prognosis, and management of orbital tumors in acute lymphoblastic leukemia.
  • Early diagnosis and treatment of orbital acute lymphoblastic leukemia with a multidisciplinary approach is essential to minimize or prevent deterioration of vision and optimize clinical outcomes.
  • [MeSH-major] Neoplasm Recurrence, Local / diagnosis. Orbital Neoplasms / diagnosis. Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
  • [MeSH-minor] Acute Disease. Biopsy. Bone Marrow / pathology. Child. Combined Modality Therapy. Diagnosis, Differential. Disease Progression. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male

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  • [Copyright] Copyright 2010, SLACK Incorporated.
  • (PMID = 20128555.001).
  • [ISSN] 0191-3913
  • [Journal-full-title] Journal of pediatric ophthalmology and strabismus
  • [ISO-abbreviation] J Pediatr Ophthalmol Strabismus
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Tomizawa D, Koh K, Hirayama M, Miyamura T, Hatanaka M, Saikawa Y, Ishii E: Outcome of recurrent or refractory acute lymphoblastic leukemia in infants with MLL gene rearrangements: A report from the Japan Infant Leukemia Study Group. Pediatr Blood Cancer; 2009 Jul;52(7):808-13
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  • [Title] Outcome of recurrent or refractory acute lymphoblastic leukemia in infants with MLL gene rearrangements: A report from the Japan Infant Leukemia Study Group.
  • BACKGROUND: Despite the poor outcome of recurrent or refractory acute lymphoblastic leukemia (ALL) in infants with MLL gene rearrangement, few studies have focused on this specific group.
  • Young age (<3 months) and central nervous system involvement at initial diagnosis were associated with poor outcome; however, failure to achieve remission after salvage therapy was the sole independent poor prognostic factor in multivariate analysis (P = 0.01).
  • [MeSH-major] Drug Resistance, Neoplasm. Myeloid-Lymphoid Leukemia Protein / genetics. Neoplasm Recurrence, Local / genetics. Neoplasm Recurrence, Local / therapy. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics. Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19229974.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MLL protein, human; 149025-06-9 / Myeloid-Lymphoid Leukemia Protein; EC 2.1.1.43 / Histone-Lysine N-Methyltransferase
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75. Rabin K, Man TK, Lau CC: Personalized care of pediatric cancer patients. Nestle Nutr Workshop Ser Pediatr Program; 2008;62:173-85; discussion 185-8
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  • One of the great success stories of clinical oncology is the improvement in the cure rates of pediatric acute lymphoblastic leukemia (ALL) from around 10% in the 1960s to nearly 90% today.
  • These encouraging results suggest that the genomic approach will revolutionize the diagnosis and prognosis of pediatric cancer patients and improve their outcome through predictive, personalized care.
  • [MeSH-major] Bone Neoplasms / drug therapy. Drug Resistance, Neoplasm / genetics. Gene Expression Profiling. Osteosarcoma / drug therapy. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy

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  • (PMID = 18626200.001).
  • [ISSN] 1661-6677
  • [Journal-full-title] Nestlé Nutrition workshop series. Paediatric programme
  • [ISO-abbreviation] Nestle Nutr Workshop Ser Pediatr Program
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA109467; United States / NCI NIH HHS / CA / CA114757; United States / NCI NIH HHS / CA / CA88126; United States / NCI NIH HHS / CA / CA97874
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Genetic Markers
  • [Number-of-references] 31
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76. Buonuomo PS, Maurizi P, Bracaglia C, Margani G, Riccardi R: Primary Sjögren's syndrome mimicking lymphoma in a pediatric patient. A rare and possibly misdiagnosed condition. Minerva Pediatr; 2009 Feb;61(1):119-22
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  • [Title] Primary Sjögren's syndrome mimicking lymphoma in a pediatric patient. A rare and possibly misdiagnosed condition.
  • A 12-year-old girl presented at the Oncoemato-logic Department with an acute onset of generalized lymphadenopathy.
  • Revaluating the diagnosis, anamnestic data revealed multiple episodes of bilateral parotid swelling since age one, without systemic symptoms.
  • [MeSH-major] Diagnostic Errors. Lymphoma / diagnosis. Sjogren's Syndrome / diagnosis
  • [MeSH-minor] Child. Diagnosis, Differential. Female. Humans

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  • (PMID = 19180009.001).
  • [ISSN] 0026-4946
  • [Journal-full-title] Minerva pediatrica
  • [ISO-abbreviation] Minerva Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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77. Konn ZJ, Wright SL, Barber KE, Harrison CJ: Fluorescence In situ hybridization (FISH) as a tool for the detection of significant chromosomal abnormalities in childhood leukaemia. Methods Mol Biol; 2009;538:29-55
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  • Cytogenetics is integral to the diagnosis of childhood leukaemia, particularly in relation to the risk stratification of patients for treatment.
  • The range of procedures necessary for the successful application of FISH in the accurate detection of significant chromosomal abnormalities in childhood acute leukaemia is described here.
  • [MeSH-major] Chromosome Aberrations. In Situ Hybridization, Fluorescence / methods. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics

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  • (PMID = 19277578.001).
  • [ISSN] 1064-3745
  • [Journal-full-title] Methods in molecular biology (Clifton, N.J.)
  • [ISO-abbreviation] Methods Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Probes
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78. Ramos CA, Saliba RM, de Pádua L, Khorshid O, Shpall EJ, Giralt S, Patah PA, Hosing CM, Popat UR, Rondon G, Khouri IF, Nieto YL, Champlin RE, de Lima M: Impact of hepatitis C virus seropositivity on survival after allogeneic hematopoietic stem cell transplantation for hematologic malignancies. Haematologica; 2009 Feb;94(2):249-57
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  • Matched controls (N=31) were seronegative for viral hepatitides and were paired according to age, diagnosis, disease stage, conditioning regimen and donor type.
  • RESULTS: The median age of the seropositive patients was 49 (range 26-72); 15 had acute myeloid leukemia/myelodysplastic syndrome, 6 had chronic myeloid leukemia/myeloproliferative disease, 6 non-Hodgkin's lymphoma, 2 myeloma, 1 acute lymphocytic leukemia and 1 Hodgkin's lymphoma; 61% had poor risk disease; 68% had related donors; 68% received reduced intensity conditioning; 7 patients had mildly abnormal alanine transaminase levels (all less than three times the upper limit of normal) and 1 patient had minimally elevated bilirubin.

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  • (PMID = 19144658.001).
  • [ISSN] 1592-8721
  • [Journal-full-title] Haematologica
  • [ISO-abbreviation] Haematologica
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2635398
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79. Erduran E, Tekelioglu Y, Karakas T, Gedik Y, Mert FM: Comparision of the apoptotic effects on lymphoblasts and on increase of myeloid lineage cells of a short-time, high-dose methylprednisolone and the conventional-dose prednisolone treatments in children with acute lymphoblastic leukemia. Pediatr Hematol Oncol; 2006 Oct-Nov;23(7):587-98
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  • [Title] Comparision of the apoptotic effects on lymphoblasts and on increase of myeloid lineage cells of a short-time, high-dose methylprednisolone and the conventional-dose prednisolone treatments in children with acute lymphoblastic leukemia.
  • The authors compare the apoptotic effect on the lymphoblasts and the proliferative effect on the myeloid lineage cells of a short-course high-dose methylprednisolone (HDMP) and the conventional-dose prednisolone treatments in children with acute lymphoblastic leukemia (ALL).
  • The apoptotic percentages of lymphpblasts and the percentages of blasts and myeloid lineage cells were determined after performing the bone marrow aspiration (BMA) at diagnosis on the 0th, 3rd, and 7th days of the treatments in all patients.
  • [MeSH-major] Apoptosis / drug effects. Lymphocytes / drug effects. Methylprednisolone / administration & dosage. Myeloid Cells / drug effects. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Prednisolone / administration & dosage

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  • (PMID = 16928654.001).
  • [ISSN] 1521-0669
  • [Journal-full-title] Pediatric hematology and oncology
  • [ISO-abbreviation] Pediatr Hematol Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD33 protein, human; 0 / Sialic Acid Binding Ig-like Lectin 3; 9PHQ9Y1OLM / Prednisolone; EC 3.4.11.2 / Antigens, CD13; X4W7ZR7023 / Methylprednisolone
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80. Monfared A, Orangpoor RO, Fakheri TF, Falahatkar S: Acute renal failure and bilateral kidney infiltration as the first presentation of non-Hodgkin lymphoma. Iran J Kidney Dis; 2009 Jan;3(1):50-3
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  • [Title] Acute renal failure and bilateral kidney infiltration as the first presentation of non-Hodgkin lymphoma.
  • Diffuse bilateral infiltration of the kidneys by lymphoma is probably the rarest cause of renal insufficiency.
  • Moreover, acute renal failure as the initial manifestation of the lymphoma is reported only in a few cases.
  • A 44-year-old man complaining of bilateral flank pain and weakness for 2 months was admitted with acute renal failure.
  • Open kidney biopsy was performed and infiltrated cells positive for CD20 and negative for CD3 markers were observed based upon which diagnosis of diffuse large B-cell type non-Hodgkin lymphoma was made.
  • [MeSH-major] Acute Kidney Injury / etiology. Kidney / pathology. Lymphoma, Non-Hodgkin / diagnosis

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  • (PMID = 19377260.001).
  • [ISSN] 1735-8582
  • [Journal-full-title] Iranian journal of kidney diseases
  • [ISO-abbreviation] Iran J Kidney Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Iran
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81. Medyouf H, Gao X, Armstrong F, Gusscott S, Liu Q, Gedman AL, Matherly LH, Schultz KR, Pflumio F, You MJ, Weng AP: Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss. Blood; 2010 Feb 11;115(6):1175-84
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  • [Title] Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss.
  • NOTCH1 is activated by mutation in more than 50% of human T-cell acute lymphoblastic leukemias (T-ALLs) and inhibition of Notch signaling causes cell-cycle/growth arrest, providing rationale for NOTCH1 as a therapeutic target.
  • We also examined 13 primary human T-ALL samples obtained at diagnosis and found no correlation between PTEN status and resistance to Notch inhibition.

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  • (PMID = 20008304.001).
  • [ISSN] 1528-0020
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / K22 CA112538; United States / NCI NIH HHS / CA / R01 CA076641; United States / NCI NIH HHS / CA / T32 CA009531; United States / NCI NIH HHS / CA / CA76641
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cdkn2a protein, mouse; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Enzyme Inhibitors; 0 / Il2rg protein, mouse; 0 / Interleukin Receptor Common gamma Subunit; 0 / RNA, Messenger; 0 / Receptor, Notch1; EC 3.1.3.67 / PTEN Phosphohydrolase; EC 3.4.- / Amyloid Precursor Protein Secretases
  • [Other-IDs] NLM/ PMC2826229
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82. Sekiguchi N, Watanabe T, Kobayashi Y, Inokuchi C, Kim SW, Yokota Y, Tanimoto K, Matsuno Y, Tobinai K: The application of molecular analyses for primary granulocytic sarcoma with a specific chromosomal translocation. Int J Hematol; 2005 Oct;82(3):210-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Immunohistochemical staining for myeloperoxidase is necessary for a definite diagnosis.
  • Otherwise, primary GS is often misdiagnosed as a malignant lymphoma or other malignancies.
  • Primary GS is well known to frequently develop into acute myeloid leukemia (AML).
  • These molecular analyses provide a precise method of diagnosis, especially with respect to the French-American-British AML classification, according to the characteristic karyotypic alterations, and a patient consequently can quickly be given appropriate systemic chemotherapy as induction therapy.

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  • (PMID = 16207593.001).
  • [ISSN] 0925-5710
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / AML1-ETO fusion protein, human; 0 / Antimetabolites, Antineoplastic; 0 / Core Binding Factor Alpha 2 Subunit; 0 / Oncogene Proteins, Fusion; 04079A1RDZ / Cytarabine
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83. Chow EJ, Friedman DL, Stovall M, Yasui Y, Whitton JA, Robison LL, Sklar CA: Risk of thyroid dysfunction and subsequent thyroid cancer among survivors of acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. Pediatr Blood Cancer; 2009 Sep;53(3):432-7
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  • [Title] Risk of thyroid dysfunction and subsequent thyroid cancer among survivors of acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study.
  • BACKGROUND: To determine the risk of thyroid dysfunction and subsequent thyroid cancer among childhood acute lymphoblastic leukemia (ALL) survivors.
  • RESULTS: The cumulative incidence of hypo- and hyperthyroidism among survivors 15 years following leukemia diagnosis was 1.6% (95% CI 1.1, 2.1) and 0.6% (95% CI 0.3, 1.1), respectively, both significantly increased compared with siblings.


84. Xu R, Anagnostopoulos GC, Wunsch DC 2nd: Multiclass cancer classification using semisupervised ellipsoid ARTMAP and particle swarm optimization with gene expression data. IEEE/ACM Trans Comput Biol Bioinform; 2007 Jan-Mar;4(1):65-77
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  • It is crucial for cancer diagnosis and treatment to accurately identify the site of origin of a tumor.
  • The effectiveness of ssEAM/PSO for multiclass cancer diagnosis is demonstrated by testing it on three publicly available multiple-class cancer data sets. ssEAM/PSO achieves competitive performance on all these data sets, with results comparable to or better than those obtained by other classifiers.

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  • (PMID = 17277414.001).
  • [ISSN] 1545-5963
  • [Journal-full-title] IEEE/ACM transactions on computational biology and bioinformatics
  • [ISO-abbreviation] IEEE/ACM Trans Comput Biol Bioinform
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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85. Hori T, Suzuki N, Mizue N, Hatakeyama N, Takamuro M, Tsutsumi H: Relapse of T-cell all after stem cell transplant presenting as hypertrophic cardiomyopathy: the value of non-invasive diagnostic imaging in detecting cardiac leukemia. Pediatr Blood Cancer; 2006 Jan;46(1):108-11
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  • We describe a 14-year-old female with acute lymphoblastic leukemia (ALL) with a mediastinal mass at diagnosis who developed hypertrophic cardiomyopathy (HC) after stem cell transplantation (SCT).
  • [MeSH-major] Cardiomyopathy, Hypertrophic / etiology. Diagnostic Imaging. Leukemia-Lymphoma, Adult T-Cell / pathology. Leukemic Infiltration. Myocardium / pathology


86. Karanth M, Taniere P, Barraclough J, Murray JA: A rare presentation of zygomycosis (mucormycosis) and review of the literature. J Clin Pathol; 2005 Aug;58(8):879-81
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  • This report describes a 56 year old woman who developed this infection while receiving chemotherapy for acute lymphoblastic leukaemia.
  • Medical and surgical measures proved unsuccessful because there was a delay in diagnosis and institution of appropriate treatment.
  • [MeSH-major] Intestinal Diseases / diagnosis. Mucormycosis / diagnosis. Opportunistic Infections / diagnosis
  • [MeSH-minor] Female. Humans. Immunocompromised Host. Middle Aged. Neutropenia / complications. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy

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  • (PMID = 16049294.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 17
  • [Other-IDs] NLM/ PMC1770885
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87. Zhou PY, Li WJ, Wei CX, Zhou Z: [Expression of PRAME gene in adult acute leukemia and its significance in prognosis]. Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2007 Dec;15(6):1177-81
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  • [Title] [Expression of PRAME gene in adult acute leukemia and its significance in prognosis].
  • The study was aimed to investigate the expression of preferentially expressed antigen of melanoma (PRAME) gene in adult acute leukemia and its clinical significance.
  • The expression of the PRAME gene of bone marrow was measured by reverse transcriptase polymerase chain reaction (RT-PCR) in 73 adult newly diagnosed acute leukemia patients, 3 relapsed patients, 7 patients with idiopathic thrombocytopenic purpura (ITP) and 8 healthy donors, as well as two AL cell-lines (K562 and U937).
  • PRAME expression not correlated to the white blood count, hemoglobin level, platelet count and the percentage of blasts at diagnosis, yet independent of age, sex, and FAB type.
  • PRAME gene was overexpressed in adult acute leukemia patients and leukemia cell-lines.
  • It is concluded that the expression of PRAME is an indicator of favorable prognosis and can be a useful tool for monitoring minimal residual disease (MRD) in adult acute leukemia.
  • Differential expression between adult acute leukemia patients and healthy volunteers suggests that the immunogenic antigens PRAME are potential candidates for immunotherapy in adult acute leukemia.

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  • (PMID = 18088461.001).
  • [ISSN] 1009-2137
  • [Journal-full-title] Zhongguo shi yan xue ye xue za zhi
  • [ISO-abbreviation] Zhongguo Shi Yan Xue Ye Xue Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / PRAME protein, human; 0 / RNA, Messenger
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88. Dixit A, Kannan M, Mahapatra M, Choudhry VP, Saxena R: Roles of protein C, protein S, and antithrombin III in acute leukemia. Am J Hematol; 2006 Mar;81(3):171-4
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  • [Title] Roles of protein C, protein S, and antithrombin III in acute leukemia.
  • Protein C, protein S, and antithrombin III were measured in 35 patients with acute leukemia (13 with AML and 22 with ALL).
  • The low levels of protein C and ATIII found at diagnosis had risen to normal levels at the end of the induction therapy, while low =levels of protein S remained in 75% of the patients.
  • Whether the low protein C, protein S, or antithrombin levels predispose patients with acute leukemia to thrombosis in the absence of DIC is not known.
  • [MeSH-major] Antithrombin III / analysis. Leukemia, Myeloid, Acute / blood. Precursor Cell Lymphoblastic Leukemia-Lymphoma / blood. Protein C / analysis. Protein S / analysis

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  • (PMID = 16493609.001).
  • [ISSN] 0361-8609
  • [Journal-full-title] American journal of hematology
  • [ISO-abbreviation] Am. J. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protein C; 0 / Protein S; 04079A1RDZ / Cytarabine; 5J49Q6B70F / Vincristine; 8N3DW7272P / Cyclophosphamide; 9000-94-6 / Antithrombin III; E7WED276I5 / 6-Mercaptopurine; EC 3.5.1.1 / Asparaginase; VB0R961HZT / Prednisone; YL5FZ2Y5U1 / Methotrexate; BFM-86 protocol
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89. Vilela MI, Viana MB: Longitudinal growth and risk factors for growth deficiency in children treated for acute lymphoblastic leukemia. Pediatr Blood Cancer; 2007 Jan;48(1):86-92
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  • [Title] Longitudinal growth and risk factors for growth deficiency in children treated for acute lymphoblastic leukemia.
  • BACKGROUND: Growth deficit has been reported as a frequent complication of the treatment of acute lymphoblastic leukemia (ALL).
  • Only girls younger than 10 and boys younger than 12 years old at diagnosis were included.
  • Patients were aggregated into five non-excluding groups according to availability of height data at diagnosis, during the treatment, at the end of it, and several years after; 35 children reached their final height.
  • Multivariate analysis demonstrated that growth impairment was more severe in children younger than 4 years at diagnosis and in those who received cranial irradiation.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / adverse effects. Cranial Irradiation / adverse effects. Growth Disorders / etiology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16700045.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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90. Wanschitz J, Dichtl W, Budka H, Löscher WN, Boesch S: Acute motor and sensory axonal neuropathy in Burkitt-like lymphoma. Muscle Nerve; 2006 Oct;34(4):494-8
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  • [Title] Acute motor and sensory axonal neuropathy in Burkitt-like lymphoma.
  • Immune-mediated neuropathies associated with non-Hodgkin's lymphoma are rare and can be difficult to delineate from neuropathies of other etiologies.
  • We report the clinical and pathological findings of a 36-year-old patient with fulminant quadriplegic neuropathy, left facial nerve palsy, and Burkitt-like lymphoma.
  • We hypothesize that immune mechanisms triggered by the lymphoma initiated damage to the peripheral nervous system and enhanced its vulnerability to the toxic effects of vincristine.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / adverse effects. Burkitt Lymphoma / drug therapy. Peripheral Nervous System Diseases / chemically induced. Vincristine / adverse effects
  • [MeSH-minor] Acute Disease. Adult. Axons / drug effects. Axons / pathology. Diagnosis, Differential. Female. Guillain-Barre Syndrome / chemically induced. Guillain-Barre Syndrome / diagnosis. Humans. Quadriplegia / chemically induced

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  • (PMID = 16671108.001).
  • [ISSN] 0148-639X
  • [Journal-full-title] Muscle & nerve
  • [ISO-abbreviation] Muscle Nerve
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 5J49Q6B70F / Vincristine
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91. Caillard S, Moulin B: [Transplant patient monitoring]. Rev Prat; 2007 Feb 15;57(3):299-308
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  • Acute or chronic graft dysfunctions should be identified very soon in order to confirm diagnosis by pathologic analyses and to adapt the immunosuppressive treatment.
  • [MeSH-minor] Dyslipidemias / prevention & control. Follow-Up Studies. France. Graft Rejection / prevention & control. Graft Survival. Heart Diseases / prevention & control. Humans. Hypertension / prevention & control. Immunosuppressive Agents / adverse effects. Immunosuppressive Agents / therapeutic use. Lymphoma / prevention & control. Neoplasms / prevention & control. Opportunistic Infections / prevention & control. Postoperative Complications / prevention & control. Skin Neoplasms / prevention & control. Surgical Wound Infection / prevention & control

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  • (PMID = 17578031.001).
  • [ISSN] 0035-2640
  • [Journal-full-title] La Revue du praticien
  • [ISO-abbreviation] Rev Prat
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
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92. Tsuji H, Mochiduki A, Hosaka A, Yoshizawa T, Tamaoka A: [Intravascular lymphomatosis manifesting clinically as subacute encephalopathy]. Rinsho Shinkeigaku; 2008 May;48(5):328-32
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  • To make an appropriate diagnosis of the lesions on the brain MRI, the open brain biopsy was performed.
  • Microscopic examination showed that many small vessels were occluded by lymphoma cells (B-lymphocytes) with hemorrhage, and IVL was diagnosed.
  • IVL is a rare disease, and the prognosis is generally poor, with a rapidly fatal outcome, leading to a postmortem diagnosis.
  • [MeSH-major] Cerebral Infarction / etiology. Lymphoma, B-Cell / complications. Unconsciousness / etiology. Vascular Neoplasms / complications
  • [MeSH-minor] Acute Disease. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Murine-Derived. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers / analysis. C-Reactive Protein / analysis. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Prednisolone / administration & dosage. Receptors, Interleukin-2 / analysis. Rituximab. Vincristine / administration & dosage

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  • (PMID = 18540379.001).
  • [ISSN] 0009-918X
  • [Journal-full-title] Rinshō shinkeigaku = Clinical neurology
  • [ISO-abbreviation] Rinsho Shinkeigaku
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers; 0 / Receptors, Interleukin-2; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9007-41-4 / C-Reactive Protein; 9PHQ9Y1OLM / Prednisolone; VAP-cyclo protocol
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93. Tan S, Wang G, Peng M, Zhang X, Shen G, Jiang J, Chen F: Detection of myeloperoxidase activity in primary leukemic cells by an enhanced chemiluminescent assay for differentiation between acute lymphoblastic and non-lymphoblastic leukemia. Clin Chim Acta; 2009 May;403(1-2):216-8
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  • [Title] Detection of myeloperoxidase activity in primary leukemic cells by an enhanced chemiluminescent assay for differentiation between acute lymphoblastic and non-lymphoblastic leukemia.
  • BACKGROUND: Myeloperoxidase (MPO) plays a crucial role in the differentiation of acute lymphoblastic leukemia (ALL) and acute non-lymphoblastic leukemia (ANLL).
  • In this report, we proposed the application of the enhanced chemiluminescent (ECL) technique to the determination of MPO activity in blasts of acute leukemia (AL).
  • [MeSH-major] Leukemia, Myeloid, Acute / enzymology. Leukemia, Myeloid, Acute / pathology. Luminescent Measurements / methods. Peroxidase / metabolism. Precursor Cell Lymphoblastic Leukemia-Lymphoma / enzymology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Diagnosis, Differential. Female. HL-60 Cells. Humans. Infant. Male. Middle Aged


94. Cho YU, Park CJ, Cha CH, Chi HS, Jang S, Kim MJ, Lee KH, Lee JH, Lee JH, Seo JJ, Im HJ: [Minimal residual disease detection in acute leukemia patients by flow cytometric assay of cross-lineage antigen expression]. Korean J Lab Med; 2010 Dec;30(6):533-9
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  • [Title] [Minimal residual disease detection in acute leukemia patients by flow cytometric assay of cross-lineage antigen expression].
  • BACKGROUND: It has been demonstrated that flow cytometric detection of minimal residual disease (MRD) has a prognostic significance in the treatment of patients with acute leukemia.
  • METHODS: We analyzed the results of MRD detection in morphologically complete remission bone marrow aspirates from 89 patients with newly-diagnosed or relapsed acute leukemia, in which leukemic cells had cross-lineage antigen expression.
  • [MeSH-major] Antigens / metabolism. Flow Cytometry. Leukemia, Myeloid, Acute / diagnosis. Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
  • [MeSH-minor] Acute Disease. Adolescent. Adult. Aged. Antigens, CD / metabolism. Bone Marrow / metabolism. Child. Child, Preschool. Disease-Free Survival. Female. Humans. Infant. Male. Middle Aged. Neoplasm, Residual / diagnosis. Recurrence. Survival Rate

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  • (PMID = 21157135.001).
  • [ISSN] 1598-6535
  • [Journal-full-title] The Korean journal of laboratory medicine
  • [ISO-abbreviation] Korean J Lab Med
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Antigens; 0 / Antigens, CD
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95. Malbora B, Avci Z, Alioglu B, Tutar NU, Ozbek N: A case with mature B-cell acute lymphoblastic leukemia and pancreatic involvement at the time of diagnosis. J Pediatr Hematol Oncol; 2008 Jan;30(1):87-9
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  • [Title] A case with mature B-cell acute lymphoblastic leukemia and pancreatic involvement at the time of diagnosis.
  • Pancreatic infiltration with leukemic cells is a rare manifestation of acute lymphoblastic leukemia.
  • We report the clinical and radiologic findings of a 4-year-old boy with mature B-cell acute lymphoblastic leukemia and pancreatic involvement.
  • [MeSH-major] Leukemia, B-Cell / drug therapy. Leukemia, B-Cell / radiography. Pancreatic Neoplasms / drug therapy. Pancreatic Neoplasms / radiography. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Precursor Cell Lymphoblastic Leukemia-Lymphoma / radiography
  • [MeSH-minor] Acute Disease. Amylases / blood. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Child, Preschool. Diagnosis, Differential. Humans. Kidney Neoplasms / blood. Kidney Neoplasms / drug therapy. Kidney Neoplasms / radiography. Kidney Neoplasms / secondary. Lipase / blood. Liver Neoplasms / blood. Liver Neoplasms / drug therapy. Liver Neoplasms / radiography. Liver Neoplasms / secondary. Male. Pancreatitis / blood. Pancreatitis / drug therapy. Pancreatitis / radiography. Tomography, X-Ray Computed

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  • (PMID = 18176191.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.1.1.3 / Lipase; EC 3.2.1.- / Amylases
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96. Medlicott SA, Cox H, Dupre M, Lategan J, Auer I, Hollaar G, Debru E, Conly J: Systemic illnesses unexpectedly presenting as acute appendicitis: case studies. Can J Surg; 2008 Feb;51(1):73-4
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  • [Title] Systemic illnesses unexpectedly presenting as acute appendicitis: case studies.
  • [MeSH-major] Appendicitis / diagnosis. Leukemia, Myeloid, Acute / complications. Lymphoma, Large B-Cell, Diffuse / complications
  • [MeSH-minor] Acute Disease. Adult. Amphotericin B / therapeutic use. Antifungal Agents / therapeutic use. Candidiasis / diagnosis. Candidiasis / drug therapy. Female. Fluconazole / therapeutic use. Humans. Liver Diseases / microbiology. Middle Aged. Splenic Diseases / microbiology

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  • (PMID = 18248709.001).
  • [ISSN] 1488-2310
  • [Journal-full-title] Canadian journal of surgery. Journal canadien de chirurgie
  • [ISO-abbreviation] Can J Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Antifungal Agents; 7XU7A7DROE / Amphotericin B; 8VZV102JFY / Fluconazole
  • [Other-IDs] NLM/ PMC2386311
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97. Kim MK, Cho HS, Bae YK, Lee KH, Ki CS, Lee ST, Hyun MS: Therapy-related myeloid neoplasm in a patient with TP53 mutation: a dilemma in allogeneic stem cell transplant. Leuk Lymphoma; 2010 Jun;51(6):1144-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Leukemia, Myeloid / diagnosis. Mutation. Neoplasms, Second Primary / diagnosis. Tumor Suppressor Protein p53 / genetics
  • [MeSH-minor] Acute Disease. Adult. Base Sequence. Diagnosis, Differential. Female. Humans. Risk Assessment. Sequence Analysis, DNA. Stem Cell Transplantation / methods. Transplantation, Homologous

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  • (PMID = 20443677.001).
  • [ISSN] 1029-2403
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53
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98. Rehbinder B, Wullstein Ch, Bechstein WO, Probst M, Engels K, Kriener S, Döbert N, Schwarz W, Brixner V, Steffan D, Gauer S, Geiger H, Hauser IA: Epstein-barr virus-associated posttransplant lymphoproliferative disorder of donor origin after simultaneous pancreas-kidney transplantation limited to pancreas allograft: A case report. Am J Transplant; 2006 Oct;6(10):2506-11
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  • However, screening for EBV-associated lymphoma was negative.
  • After an 18F-Fluorodeoxyglucose positron emission tomography positive signal and an abnormal computed tomography scan of the pancreas transplant, a biopsy revealed a diffuse large monomorphic B-cell lymphoma, which was confined to the grafted organ.
  • After 10 weeks, the patient developed an acute hemolytic uremic syndrome which required explantation of the allografts.
  • Subsequent to the intervention, fever disappeared, EBV DNA became undetectable and lymphoma screening remained negative.
  • [MeSH-major] Burkitt Lymphoma / etiology. Kidney Transplantation / adverse effects. Pancreas Transplantation / adverse effects
  • [MeSH-minor] Adult. Biopsy. DNA, Viral / analysis. Diabetes Mellitus, Type 1 / surgery. Diagnosis, Differential. Follow-Up Studies. Herpesvirus 4, Human / genetics. Humans. Male. Middle Aged. Positron-Emission Tomography. Tomography, X-Ray Computed. Transplantation, Homologous

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  • (PMID = 16869797.001).
  • [ISSN] 1600-6135
  • [Journal-full-title] American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • [ISO-abbreviation] Am. J. Transplant.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / DNA, Viral
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99. Cole PD, Kamen BA: Delayed neurotoxicity associated with therapy for children with acute lymphoblastic leukemia. Ment Retard Dev Disabil Res Rev; 2006;12(3):174-83
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  • [Title] Delayed neurotoxicity associated with therapy for children with acute lymphoblastic leukemia.
  • Most children diagnosed today with acute lymphoblastic leukemia (ALL) will be cured.
  • [MeSH-major] Antineoplastic Agents / adverse effects. Brain / drug effects. Brain / radiation effects. Cranial Irradiation / adverse effects. Developmental Disabilities / etiology. Intellectual Disability / etiology. Neurotoxicity Syndromes / etiology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Precursor Cell Lymphoblastic Leukemia-Lymphoma / radiotherapy. Radiation Injuries / etiology
  • [MeSH-minor] Child. Demyelinating Diseases / diagnosis. Demyelinating Diseases / etiology. Folic Acid / physiology. Humans. Neuropsychological Tests. Risk Factors

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 17061283.001).
  • [ISSN] 1080-4013
  • [Journal-full-title] Mental retardation and developmental disabilities research reviews
  • [ISO-abbreviation] Ment Retard Dev Disabil Res Rev
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 935E97BOY8 / Folic Acid
  • [Number-of-references] 165
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100. Choi J, Hwang YK, Sung KW, Kim DH, Yoo KH, Jung HL, Koo HH: Aven overexpression: association with poor prognosis in childhood acute lymphoblastic leukemia. Leuk Res; 2006 Aug;30(8):1019-25
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  • [Title] Aven overexpression: association with poor prognosis in childhood acute lymphoblastic leukemia.
  • In this study, Aven expression in 91 children with acute lymphoblastic leukemia (ALL) was investigated for possible correlation with clinical features at diagnosis and treatment outcome.
  • [MeSH-major] Adaptor Proteins, Signal Transducing / biosynthesis. Adaptor Proteins, Signal Transducing / genetics. Apoptosis Regulatory Proteins / biosynthesis. Apoptosis Regulatory Proteins / genetics. Gene Expression Profiling. Membrane Proteins / biosynthesis. Membrane Proteins / genetics. Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics

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  • (PMID = 16388850.001).
  • [ISSN] 0145-2126
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / AVEN protein, human; 0 / Adaptor Proteins, Signal Transducing; 0 / Apoptosis Regulatory Proteins; 0 / Membrane Proteins
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