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11. Voll R: [A rare differential diagnosis of a somatoform autonomous disorder of the gastro-intestinal tract: the hepatocellular liver carcinoma in childhood]. Z Kinder Jugendpsychiatr Psychother; 2008 Jul;36(4):275-8
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  • [Title] [A rare differential diagnosis of a somatoform autonomous disorder of the gastro-intestinal tract: the hepatocellular liver carcinoma in childhood].
  • [Transliterated title] Eine seltene Differenzialdiagnose somatoformer autonomer Funktionsstörung des Abdominaltraktes: das hepatozelluläre Leberkarzinom in der Kindheit.
  • OBJECTIVES: A severely ill 11-year-old boy came to the child psychiatric outpatient department of the Fachkrankenhaus Neckargemünd with the diagnosis of a somatoform disorder.
  • CONCLUSIONS: The symptoms of the hepatocellular carcinoma, which rarely occurs in childhood, can perfectly mimic those of a somatoform disorder of the gastro-intestinal tract.
  • [MeSH-minor] Child. Child Reactive Disorders / diagnosis. Child Reactive Disorders / psychology. Child Reactive Disorders / therapy. Combined Modality Therapy. Diagnosis, Differential. Family Therapy. Follow-Up Studies. Hepatectomy / psychology. Humans. Male. Neuropsychological Tests. Psychotherapy. Referral and Consultation. Sick Role

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  • (PMID = 18654959.001).
  • [ISSN] 1422-4917
  • [Journal-full-title] Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie
  • [ISO-abbreviation] Z Kinder Jugendpsychiatr Psychother
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Switzerland
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12. Brainin E, Teicher S: [The terror from the outside--child survivors of the Spiegelgrund traumatic experiences in childhood and their effects]. Prax Kinderpsychol Kinderpsychiatr; 2009;58(7):530-52
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  • [Title] [The terror from the outside--child survivors of the Spiegelgrund traumatic experiences in childhood and their effects].
  • [Transliterated title] Terror von aussen am Beispiel Spiegelgrund Traumatische Erfahrungen in der Kindheit und deren Folgen.
  • The overcoming and dealing with the terrible past during childhood were discussed as well as the reactions to the interviews of the members of the study group.
  • The theoretical frame was Anna Freud's work on child survivors of the Theresienstadt concentration camp: "An Experiment in Group Upbringing": Different factors for the survival and the working through afterwards are discussed as well as the different psychoanalytical trauma concepts.
  • The former experiences of the children in institutions of the social administration in Austria differ from the experiences of Jewish child survivors.
  • [MeSH-minor] Adolescent. Austria. Child. Germany. History, 20th Century. Humans

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  • (PMID = 19911766.001).
  • [ISSN] 0032-7034
  • [Journal-full-title] Praxis der Kinderpsychologie und Kinderpsychiatrie
  • [ISO-abbreviation] Prax Kinderpsychol Kinderpsychiatr
  • [Language] ger
  • [Publication-type] English Abstract; Historical Article; Journal Article
  • [Publication-country] Germany
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13. Schmidt-Bacher AE, Kahlert C, Kolling G: [Accuracy of two autorefractors--Pediatric Autorefractor plusoptiX and Retinomax--in cycloplegic children in comparison to retinoscopy]. Klin Monbl Augenheilkd; 2010 Oct;227(10):792-7
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  • [Title] [Accuracy of two autorefractors--Pediatric Autorefractor plusoptiX and Retinomax--in cycloplegic children in comparison to retinoscopy].
  • [Transliterated title] Zur Messung der objektiven Refraktion in Zykloplegie im Kindesalter mit Skiaskopie und automatischer Refraktometrie mit dem Pediatric Autorefractor und dem Retinomax.
  • In a prospective study we compared readings from two hand-held photorefractors, the Pediatric Autorefractor and the Retinomax, to those from retinoscopy.
  • All patients underwent standardised cycloplegia measurements first by the Pediatric Autorefractor plusoptiX A 08 in 1 metre working distance, then adding an infrared filter to reduce interferences, followed by the Retinomax K-plus 3 in 5 cm working distance and retinoscopy as reference on the right eye.
  • RESULTS: Spherical equivalents measured by the Pediatric Autorefractor plusoptiX A 08 coincided in 51.2% with retinoscopy (± 0.5 D).
  • The Pediatric Autorefractor is not suited for everyday clinical routine due to a low success rate of 50% and tight measuring range of + 5.0 to -7.0 D in spherical equivalents.
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Equipment Design. Female. Humans. Infant. Male. Ophthalmic Solutions. Sensitivity and Specificity

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  • [Copyright] © Georg Thieme Verlag KG Stuttgart · New York.
  • [CommentIn] Klin Monbl Augenheilkd. 2012 Oct;229(10):1045; author reply 1046 [23096147.001]
  • (PMID = 20963682.001).
  • [ISSN] 1439-3999
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Mydriatics; 0 / Ophthalmic Solutions; I76F4SHP7J / Cyclopentolate
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4. Lampert T: [Setting the course early: relevance of childhood and adolescence for health in later life]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz; 2010 May;53(5):486-97
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  • [Title] [Setting the course early: relevance of childhood and adolescence for health in later life].
  • [Transliterated title] Frühe Weichenstellung: Zur Bedeutung der Kindheit und Jugend für die Gesundheit im späteren Leben.
  • The article examines the importance of childhood and adolescence for health in later life against the background of the population-aging process and the debate on the social challenges expected to result from this process.
  • [MeSH-major] Adolescent Development. Child Development. Chronic Disease / epidemiology. Disabled Persons / statistics & numerical data. Population Dynamics
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Forecasting. Germany. Health Promotion / trends. Health Services Needs and Demand / trends. Humans. Infant. Infant, Newborn. Middle Aged. Pregnancy. Primary Prevention / trends. Risk Factors. Young Adult


15. Hardt J, Hoffmann SO: [Childhood in flux--Part I: Ancient world until modern times]. Prax Kinderpsychol Kinderpsychiatr; 2006;55(4):271-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Childhood in flux--Part I: Ancient world until modern times].
  • [Transliterated title] Kindheit im Wandel--Teil I: Antike bis zur Neuzeit.
  • Scientific research on childhood constitutes a relatively new field.
  • Until medieval times, a child's life did not count for much, that is, as long as the child was not the beneficiary of an inheritance.
  • Despite Rousseau's idealistic concept of education as a kind of identification process for the child, he put his own five children into the foundling hospital of Paris; he was bothered by them when writing.
  • Up to the beginning of the 19th century, the value of a child was determined by his or her ability to work.
  • [MeSH-major] Child Abuse / history. Child Care / history. Child, Abandoned / history. Employment / history. Infanticide / history. Social Values
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Europe. Female. History, 15th Century. History, 16th Century. History, 17th Century. History, 18th Century. History, 19th Century. History, Ancient. History, Medieval. Humans. Infant. Male. United States

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  • (PMID = 17436560.001).
  • [ISSN] 0032-7034
  • [Journal-full-title] Praxis der Kinderpsychologie und Kinderpsychiatrie
  • [ISO-abbreviation] Prax Kinderpsychol Kinderpsychiatr
  • [Language] ger
  • [Publication-type] English Abstract; Historical Article; Journal Article
  • [Publication-country] Germany
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16. Fauzdar A, Mahajan A, Jain D, Mishra M, Raina V: Amplification of RUNX1 gene in two new cases of childhood B-cell precursor acute lymphoblastic leukemia: A case report. J Clin Oncol; 2009 May 20;27(15_suppl):e21000

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Amplification of RUNX1 gene in two new cases of childhood B-cell precursor acute lymphoblastic leukemia: A case report.
  • : e21000 Background: Chromosome abnormalities of leukemia cells have important prognostic significance in childhood acute lymphoblastic leukemia (ALL).
  • B-cell precursor acute lymphoblastic leukemia (BCP-ALL) ETV6/RUNX1 (alias TEL/AML1) is most frequent i.e.
  • Bone marrow karyotype in combination with molecular cytogenetic techniques like FISH should be done for improvement in sensitivity and accurate cytogenetic analysis in childhood ALL patients for proper identification of prognostic group for optimum treatment.
  • This is one of the few reported studies worldwide for amplification of RUNX1 gene from Indian subcontinent in childhood BCP-ALL.

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  • (PMID = 27960689.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Meyer LH, Zangrando A, Eckhoff SM, Queudeville M, Vendramini E, Basso G, Te Kronnie G, Debatin K: Association of time to leukemia (TTL) in NOD/SCID mice with expression of apoptosis regulators in pediatric ALL. J Clin Oncol; 2009 May 20;27(15_suppl):10042

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association of time to leukemia (TTL) in NOD/SCID mice with expression of apoptosis regulators in pediatric ALL.
  • : 10042 Background: Acute lymphoblastic leukemia (ALL) is the most frequent malignant disease in childhood.
  • In a recent study we transplanted pediatric leukemia samples from newly diagnosed BCP-ALL patients into NOD/SCID mice.
  • Time to leukemia (TTL) was analyzed for each patient sample as time from transplant to overt leukemia in the recipients.
  • Patients whose leukemia cells engrafted rapidly showed a clearly inferior relapse free survival in contrast to patient samples with prolonged in vivo growth.
  • METHODS: Gene expression profiles of ALL samples (N = 14) with short versus long TTL in the xenograft model were analyzed using a human whole genome array (Affymetrix U133 Plus 2.0) correlating gene expression values (relative expression) to the time from transplant to manifestation of leukemia in the NOD/SCID mice (TTL, in weeks) by quantitative traits analysis (QTA).
  • Patient samples exhibiting a short time to overt leukemia in the xenotransplant model associated with poor relapse free survival showed down-regulated XAF1 and impaired caspase-3 activation leading to decreased apoptosis of the leukemia cells.
  • CONCLUSIONS: Taken together, we used a novel approach directly correlating gene expression values to time from transplant to overt leukemia (TTL) identifying the apoptosis regulator XAF1 to be associated with poor outcome of patients.
  • Small XIAP-inhibiting molecules can be used to substitute the lacking inhibitory effect of down-regulated XAF1 in these poor responding pediatric ALL patients.

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  • (PMID = 27962468.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Mukhopadhyay A, Gupta P, Mukhopadhyay S, Dey S, Basak J, Pandey R: Result of adolescent acute lymphoblastic leukemia protocol (MCP 841) from a developing country. J Clin Oncol; 2009 May 20;27(15_suppl):10046

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Result of adolescent acute lymphoblastic leukemia protocol (MCP 841) from a developing country.
  • : 10046 Background: Acute Lymphatic Leukemia is a curable disease in the range of 80 - 90% in developed countries by aggressive protocol like BFM, St. Judes' but result is much less in adolescence age group (60-70%).
  • As compared to our all pediatric ALL group the outcome is much less and complications are much more.
  • CONCLUSIONS: The data of acute lymphatic leukemia in adolescent is not satisfactory as compared to other pediatric patients.

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  • (PMID = 27962472.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Queudeville M, Eckhoff SM, Debatin K, Meyer LH: Correlatoin of apoptosis signaling in primary pediatric BCP-ALL xenograft cells with the kinetics of engraftment in vivo in a NOD/SCID model and patient outcome. J Clin Oncol; 2009 May 20;27(15_suppl):10043

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Correlatoin of apoptosis signaling in primary pediatric BCP-ALL xenograft cells with the kinetics of engraftment in vivo in a NOD/SCID model and patient outcome.
  • : 10043 Background: We previously identified the importance of intact apoptosis signaling for treatment response in pediatric ALL and AML by analyzing two key apoptogenic events, caspase-3 activation and cytochrome c release.
  • Using a NOD/SCID mouse model for pediatric BCP-ALL we found that short time from transplant to overt leukemia in the recipient mice (short time to leukemia, TTLshort) determines poor patient outcome.
  • METHODS: In this study we investigated the importance of deficient apoptosis signaling for leukemia engraftment in this model.
  • CONCLUSIONS: Our finding in the NOD/SCID/huALL model matches our results in pediatric ALL and AML to conclude that the functional integrity of a downstream apoptotic checkpoint is an important feature regulating leukemia biology.
  • Thus, deficient apoptosis signaling appears to determine rapid engraftment of leukemia cells in the NOD/SCID model in vivo and consequently poor patient outcome.

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  • (PMID = 27962469.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Abdalla DM, Hamza MA, Kandil AE, Younes LK, Sorrour AF: MYCN gene amplification and DNA ploidy in peripheral neuroblastic tumors. J Clin Oncol; 2009 May 20;27(15_suppl):e22123

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : e22123 Background: Neuroblastoma is a neuroblastic tumor of the primordial crest cells which are precursors of the sympathetic nervous system and is the most common extracranial solid tumor of childhood comprising between 8 and 10% of all childhood cancers.

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  • (PMID = 27963561.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Khattab TM, Jastaniah WA, Felimban SK, Elemam N, Abdullah K, Ahmed B: How could improvement in the management of T-cell acute lymphoblastic leukemia be achieved? Experience of Princess Nourah Oncology Center, National Guard Hospital, Jeddah, Saudi Arabia. J Clin Oncol; 2009 May 20;27(15_suppl):10048

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] How could improvement in the management of T-cell acute lymphoblastic leukemia be achieved? Experience of Princess Nourah Oncology Center, National Guard Hospital, Jeddah, Saudi Arabia.
  • : 10048 Background: T-cell acute lymphoblastic leukemia (T-ALL) is representing 10-15% of pediatric ALL.
  • Our published data showed that T-ALL phenotype patients fared poorly with 5 year survival of 27% versus 83% for precursor B-ALL (Recent Advances Research Update: 2006, 7; 1, P 51-56).
  • OBJECTIVES: We reviewed all patients diagnosed with T-ALL to assess risk classification according to NCI criteria, type of therapy received, overall survival and causes of mortality.
  • METHODS: Retrospective review of all patients files diagnosed with T-ALL from 1989 until now with data collection including; sex, age, white cell count (WBCs), CNS disease, type of protocol used, length of survival, overall survival, cause of death (toxic, disease).

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  • (PMID = 27962474.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Gumy-Pause F, Ozsahin H, Khoshbeen-Boudal M, Pardo B, Betts D, Maillet P, Sappino A: ATM gene analysis in neuroblastoma: A report from the COG. J Clin Oncol; 2009 May 20;27(15_suppl):10058

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : 10058 Background: Neuroblastoma (NB) is the most common malignant disease of infancy and accounts for approximately 8% of all childhood cancers.

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  • (PMID = 27962454.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Te Loo DM, van Schie RM, Hoogerbrugge PM: Effect of azole antifungal therapy on vincristine toxicity in childhood acute lymphoblastic leukemia. J Clin Oncol; 2009 May 20;27(15_suppl):10049

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of azole antifungal therapy on vincristine toxicity in childhood acute lymphoblastic leukemia.
  • : 10049 Background: Vincristine is one of the corner stitches in the treatment of children with acute lymphoblastic leukemia (ALL).
  • METHODS: In total, twenty pediatric patients with de novo ALL were included in this study.
  • Three patients (15%) treated with azole therapy developed severe toxicity and needed treatment at the pediatric intensive care unit.

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  • (PMID = 27962456.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Evans WE, Relling MV: Pharmacogenomics of childhood acute lymphoblastic leukemia (ALL). J Clin Oncol; 2009 May 20;27(15_suppl):s3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pharmacogenomics of childhood acute lymphoblastic leukemia (ALL).
  • : s3 Childhood ALL is a model for drug-responsive cancer: it is successfully cured with medications in 85%-90% of patients, but relapse remains unacceptably high for some subgroups, and therapy is complicated by the occurrence of adverse effects.
  • Based on these studies, candidate gene genotyping has been already incorporated into the treatment of childhood ALL and integrated with electronic medical records at St. Jude to optimize use of a few medications.

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  • (PMID = 27962369.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Tai E, Richardson L, Townsend J, Steele B: Differences in length of stay among hospitalized children with acute lymphoblastic leukemia. J Clin Oncol; 2009 May 20;27(15_suppl):10044

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differences in length of stay among hospitalized children with acute lymphoblastic leukemia.
  • : 10044 Background: Acute lymphoblastic leukemia (ALL) is the most common malignancy among children in the United States.
  • METHODS: We used 2000, 2003, and 2006 data from the Healthcare Cost and Utilization Project (HCUP) Kids' Inpatient Database (KID) which contains pediatric discharges from community, non-rehabilitation hospitals.
  • CONCLUSIONS: Race/ethnicity, age, sex, household income, insurance status, admission source, hospital type and region, transfusion, bone marrow transplant, and neutropenia were significantly associated with longer LOS.

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  • (PMID = 27962470.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Smith MA, Morton CL, Carol H, Gorlick RG, Kang MH, Keir ST, Kolb EA, Lock RB, Maris JM, Houghton PJ: Pediatric Preclinical Testing Program (PPTP) testing of the CENP-E inhibitor GSK923295A. J Clin Oncol; 2009 May 20;27(15_suppl):10015

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pediatric Preclinical Testing Program (PPTP) testing of the CENP-E inhibitor GSK923295A.
  • METHODS: The PPTP includes a molecularly characterized in vitro panel of cell lines (n = 27) and in vivo panel of xenografts (n = 60) representing most of the common types of childhood solid tumors and childhood acute lymphoblastic leukemia (ALL).

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  • (PMID = 27962529.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Ikawa Y, Sugimoto N, Koizumi S, Yachie A, Saikawa Y: Promoter DNA methylation of CD10 in infant acute lymphoblastic leukemia with MLL/AF4 fusion gene. J Clin Oncol; 2009 May 20;27(15_suppl):10045

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Promoter DNA methylation of CD10 in infant acute lymphoblastic leukemia with MLL/AF4 fusion gene.
  • METHODS: CD10-negative infant ALL with MLL/AF4, CD10-positive infant ALL with germ-line MLL, CD10-positive pre-B ALL cell line, infant AML (M5) with MLL/AF9 and pediatric AML (M2) with AML1/ETO were analyzed for VDJ<sub>H</sub> status and methylation of CD10 gene promoters.
  • Bisulfite sequencing of CD 10 type 1 and 2 promoters identified more than 84% of methylated CpG dinucleotides in all three CD10-negative infant ALL cases with MLL/AF4.

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  • (PMID = 27962471.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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28. Morris B, Khan R, Ledet D, Howell C, Pui C, Hudson M, Ness K: Neurological morbidity in survivors of childhood acute lymphoblastic leukemia (ALL). J Clin Oncol; 2009 May 20;27(15_suppl):9529

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neurological morbidity in survivors of childhood acute lymphoblastic leukemia (ALL).
  • Because treatment-related neurological morbidity is recognized but poorly characterized, the objective of this cross-sectional study was to estimate the prevalence of neurological symptoms and signs in long-term survivors of childhood ALL.

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  • (PMID = 27964517.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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29. Eichstadt SL, Dahl GV, Fisher PG, Ford JM, Schiffman JD: Correlation of a family history of cancer with risk of relapse and death in pediatric cancer patients. J Clin Oncol; 2009 May 20;27(15_suppl):10029

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Correlation of a family history of cancer with risk of relapse and death in pediatric cancer patients.
  • Such information would be valuable for prognosis, refining treatment protocols, and long-term follow-up in pediatric patients with FHC.
  • METHODS: An historical cohort study of all pediatric patients diagnosed with cancer at Lucile Packard Children's Hospital at Stanford from 1999 - 2002 was performed (n = 363, mean age: 8.4 yrs [0-28 yrs]).
  • RESULTS: 108 (41%) newly diagnosed pediatric patients had reported FHC (1st Degree: n = 14 [5%], 2nd Degree: n = 58 [22%], 3rd Degree: n = 36 [14%]).
  • For patients diagnosed with any pediatric cancer and positive FHC in 1st degree relative, RR of death was significantly elevated (3.74, 95% CI 1.20-11.70).
  • CONCLUSIONS: Pediatric cancer patients with positive FHC among 1st and/or 2nd degree relatives appear to have higher relative risk of relapse compared to those with negative FHC.

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  • (PMID = 27962589.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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30. Wingenfeld K, Spitzer C, Mensebach C, Grabe HJ, Hill A, Gast U, Schlosser N, Höpp H, Beblo T, Driessen M: [The German version of the Childhood Trauma Questionnaire (CTQ): preliminary psychometric properties]. Psychother Psychosom Med Psychol; 2010 Nov;60(11):442-50
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  • [Title] [The German version of the Childhood Trauma Questionnaire (CTQ): preliminary psychometric properties].
  • [Transliterated title] Die deutsche Version des Childhood Trauma Questionnaire (CTQ): Erste Befunde zu den psychometrischen Kennwerten.
  • Given the relevance of child maltreatment for the development and treatment of many mental disorders, the objective of our study was the psychometric evaluation of the German version of the Childhood Trauma Questionnaire (CTQ).
  • The psychometric properties of the German version of the CTQ were similar to the American original; it proved to be a reliable and valid screen for the retrospective assessment of child maltreatment.
  • [MeSH-major] Adult Survivors of Child Abuse / psychology. Child Abuse / psychology. Child Abuse, Sexual / psychology
  • [MeSH-minor] Adult. Checklist. Child. Dissociative Disorders / psychology. Factor Analysis, Statistical. Female. Germany. Humans. Language. Male. Psychometrics. Reproducibility of Results. Stress Disorders, Post-Traumatic / psychology. Surveys and Questionnaires

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  • [Copyright] © Georg Thieme Verlag KG Stuttgart · New York.
  • (PMID = 20200804.001).
  • [ISSN] 0937-2032
  • [Journal-full-title] Psychotherapie, Psychosomatik, medizinische Psychologie
  • [ISO-abbreviation] Psychother Psychosom Med Psychol
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Validation Studies
  • [Publication-country] Germany
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31. Grugel L, Streicher B, Lang-Roth R, Walger M, von Wedel H, Meister H: [Development of a German version of the Functioning After Pediatric Cochlear Implantation (FAPCI) questionnaire]. HNO; 2009 Jul;57(7):678-84
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  • [Title] [Development of a German version of the Functioning After Pediatric Cochlear Implantation (FAPCI) questionnaire].
  • [Transliterated title] Entwicklung einer deutschsprachigen Version des Fragebogens Functioning After Pediatric Cochlear Implantation (FAPCI).
  • BACKGROUND: The Functioning After Pediatric Cochlear Implantation (FAPCI) instrument was recently developed to determine the communicative performance of 2-5-year-old prelingually deafened, cochlear-implanted children.
  • [MeSH-minor] Child, Preschool. Humans. Male. Reproducibility of Results. Sensitivity and Specificity. Treatment Outcome

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  • [Cites] Klin Padiatr. 2007 Mar-Apr;219(2):76-81 [16917789.001]
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  • (PMID = 19517081.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Clinical Trial; English Abstract; Journal Article
  • [Publication-country] Germany
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32. Kosseva M, Schild S, Wilhelm-Schwenk R, Biewer W, Häuser W: [Comorbid depression mediates the association of childhood/adolescent maltreatment and fibromyalgia syndrome. A study with patients from different clinical settings]. Schmerz; 2010 Sep;24(5):474-84
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  • [Title] [Comorbid depression mediates the association of childhood/adolescent maltreatment and fibromyalgia syndrome. A study with patients from different clinical settings].
  • [Transliterated title] Komorbide depressive Störungen als Mediator der Assoziation von Misshandlungen in Kindheit/Jugend und Fibromyalgiesyndrom. Eine Fallserie von Patienten aus unterschiedlichen klinischen Kontexten.
  • BACKGROUND: Emotional and physical abuse and neglect in childhood and adolescence [childhood maltreatments (CMs)] are considered to play a role in the etiology of fibromyalgia syndrome (FMS).
  • METHODS: CMs of consecutive FMS patients from three different clinical settings were assessed by the German version of the Childhood Trauma Questionnaire.
  • RESULTS: Of 328 patients (86% women, mean age 50 years), 293 were analyzed; 16% of the patients reported severe emotional, 9% severe physical, and 11% severe sexual abuse and 25% severe emotional and 13% severe physical neglect during childhood.
  • [MeSH-major] Child Abuse / psychology. Child Abuse / statistics & numerical data. Depressive Disorder / epidemiology. Depressive Disorder / psychology. Fibromyalgia / epidemiology. Fibromyalgia / psychology
  • [MeSH-minor] Adult. Child. Child Abuse, Sexual / diagnosis. Child Abuse, Sexual / psychology. Child Abuse, Sexual / statistics & numerical data. Comorbidity. Disability Evaluation. Female. Germany. Humans. Male. Middle Aged. Pain Measurement. Personality Inventory. Risk Factors

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  • (PMID = 20872126.001).
  • [ISSN] 1432-2129
  • [Journal-full-title] Schmerz (Berlin, Germany)
  • [ISO-abbreviation] Schmerz
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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33. Berkes A, Kiss M, Kemény C, Mogyorósy G: [Hungarian validation of the cardiac module of the Pediatric Quality of Life Inventory]. Orv Hetil; 2008 Nov 30;149(48):2261-8
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  • [Title] [Hungarian validation of the cardiac module of the Pediatric Quality of Life Inventory].
  • [Transliterated title] A Pediatric Quality of Life Inventory (PedsQL) gyermekkori életminoség-méro kérdoív kardiológiai moduljának magyarországi validálása.
  • The authors report the validation process of the cardiac module of the Pediatric Quality of Life Inventory (PedsQL ) into Hungarian.
  • OBJECTIVE: To adapt and to test a pediatric quality of life questionnaire for measuring HRQL in children with heart disease.
  • RESULTS: According to the results of the pilot-study the psychic domains have a negative influence on general HRQL index in both child and parent-proxy reports in all age groups.
  • Parent-child concordance is depending on the age of the child, there was expressed difference in the psychosocial domains.
  • [MeSH-minor] Activities of Daily Living. Adolescent. Anxiety / etiology. Child. Child, Preschool. Cognition. Cognition Disorders / etiology. Communication. Female. Health Status. Humans. Hungary. Male. Pediatrics. Pilot Projects. Psychometrics. Severity of Illness Index. Sickness Impact Profile


34. Cribier B, Lieber-Mbomeyo A, Lipsker D: [Clinical and histological study of a case of facial Afro-Caribbean childhood eruption (FACE)]. Ann Dermatol Venereol; 2008 Oct;135(10):663-7
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  • [Title] [Clinical and histological study of a case of facial Afro-Caribbean childhood eruption (FACE)].
  • [Transliterated title] Etude anatomoclinique d'un cas de dermatite périorale granulomateuse de l'enfant (FACE: facial Afro-Caribbean childhood eruption).
  • BACKGROUND: The term Facial Afro-Caribbean childhood eruption (FACE) was coined in 1990 to describe a perioral granulomatous eruption in black-skinned children.
  • Biopsy revealed a diffuse granulomatous infiltrate of the dermis comprising histiocytes, multinucleated giant cells and a heavy lymphocytic component.
  • DISCUSSION: This particular type of perioral dermatitis is seen chiefly in male children with black skin.
  • [MeSH-minor] African Continental Ancestry Group. Child. Humans. Male

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  • (PMID = 18929915.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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35. Hiermann P, Fries M, Hückel D, Kiess W, Merkenschlager A: [Regulatory disorders in infancy: data of the leipzig counseling service for parents with infants and toddlers]. Klin Padiatr; 2005 Mar-Apr;217(2):61-7
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  • [Transliterated title] Regulationsstörungen in der frühen Kindheit: Ergebnisse der Leipziger Beratungsstelle für Eltern mit Säuglingen und Kleinkindern.
  • CONCLUSIONS: The surveyed data support the assumption, that early childhood intervention provides help briefly and economically.
  • [MeSH-major] Child Behavior Disorders / therapy. Child Guidance / methods. Education / methods
  • [MeSH-minor] Child, Preschool. Follow-Up Studies. Humans. Infant. Infant, Newborn. Outcome Assessment (Health Care). Risk Factors. Single-Parent Family

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  • (PMID = 15770575.001).
  • [ISSN] 0300-8630
  • [Journal-full-title] Klinische Pädiatrie
  • [ISO-abbreviation] Klin Padiatr
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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36. Jenneck C, Foelster-Holst R, Hagemann T, Novak N: [Associated diseases and differential diagnostic considerations in childhood atopic eczema]. Hautarzt; 2007 Feb;58(2):163-74; quiz 175-6
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  • [Title] [Associated diseases and differential diagnostic considerations in childhood atopic eczema].
  • [Transliterated title] Differenzialdiagnose des atopischen Ekzems in der Kindheit. Erkrankungen und Syndrome in Assoziation.
  • [MeSH-minor] Child. Child, Preschool. Chronic Disease. Diagnosis, Differential. Humans. Infant

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  • (PMID = 17268788.001).
  • [ISSN] 0017-8470
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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37. Richter-Appelt H, Brinkmann L, Schützmann K: [Parental bonding in childhood and psychological symptoms in a sample of adults with intersexuality]. Psychother Psychosom Med Psychol; 2006 Aug;56(8):325-35
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  • [Title] [Parental bonding in childhood and psychological symptoms in a sample of adults with intersexuality].
  • [Transliterated title] Elterliche Bindung in der Kindheit und psychische Symptombelastung in einer Stichprobe von Erwachsenen mit Intersexualität.
  • [MeSH-minor] Adult. Child. Child Rearing. Data Collection. Female. Humans. Logistic Models. Male. Psychiatric Status Rating Scales. Surveys and Questionnaires

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  • (PMID = 16721707.001).
  • [ISSN] 0937-2032
  • [Journal-full-title] Psychotherapie, Psychosomatik, medizinische Psychologie
  • [ISO-abbreviation] Psychother Psychosom Med Psychol
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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38. Sodtke D, Armbruster MM: [ELTERN-AG--the low threshold school for parents for the early childhood]. Prax Kinderpsychol Kinderpsychiatr; 2007;56(8):707-20
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  • [Title] [ELTERN-AG--the low threshold school for parents for the early childhood].
  • [Transliterated title] ELTERN-AG-- Die niedrigschwellige Elternschule für die frühe Kindheit.
  • It works with deprived parents from the moment when they plan to get a baby up to their child's school entry.
  • [MeSH-major] Affective Symptoms / prevention & control. Child Abuse / prevention & control. Child Behavior Disorders / prevention & control. Education / methods
  • [MeSH-minor] Adaptation, Psychological. Child. Child, Preschool. Humans. Infant. Object Attachment. Parenting / psychology. Self Efficacy

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  • (PMID = 18051618.001).
  • [ISSN] 0032-7034
  • [Journal-full-title] Praxis der Kinderpsychologie und Kinderpsychiatrie
  • [ISO-abbreviation] Prax Kinderpsychol Kinderpsychiatr
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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39. Hübner B, Hechler T, Dobe M, Damschen U, Kosfelder J, Denecke H, Schroeder S, Zernikow B: [Pain-related disability in adolescents suffering from chronic pain. Preliminary examination of the Pediatric Pain Disability Index (P-PDI)]. Schmerz; 2009 Feb;23(1):20-32
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  • [Title] [Pain-related disability in adolescents suffering from chronic pain. Preliminary examination of the Pediatric Pain Disability Index (P-PDI)].
  • [Transliterated title] Schmerzbezogene Beeinträchtigung bei Jugendlichen mit chronischen Schmerzen. Erste Uberprüfung des Pediatric Pain Disability Index (P-PDI).
  • The aim of this study was to translate the Pediatric Pain Disability Index (P-PDI) of Varni into German and to investigate its psychometric qualities.
  • [MeSH-minor] Adolescent. Child. Chronic Disease. Combined Modality Therapy. Cross-Sectional Studies. Female. Follow-Up Studies. Humans. Male. Pain Management. Pain Measurement / statistics & numerical data. Principal Component Analysis. Recurrence

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  • (PMID = 18941801.001).
  • [ISSN] 1432-2129
  • [Journal-full-title] Schmerz (Berlin, Germany)
  • [ISO-abbreviation] Schmerz
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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40. Hardt J, Hoffmann SO: [Childhood in flux--Part II: Modern times until today]. Prax Kinderpsychol Kinderpsychiatr; 2006;55(4):280-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Childhood in flux--Part II: Modern times until today].
  • [Transliterated title] Kindheit im Wandel--Teil II: Moderne bis heute.
  • Bowlby in the 1950s, it became clear that children of primates need more than air, water and food, namely a relationship between the child and an adult person (attachment).
  • [MeSH-major] Child Abuse / history. Child Care / history. Child Welfare / history. Object Attachment
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Europe. History, 19th Century. History, 20th Century. History, 21st Century. Humans. Infant. United States

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  • (PMID = 17436561.001).
  • [ISSN] 0032-7034
  • [Journal-full-title] Praxis der Kinderpsychologie und Kinderpsychiatrie
  • [ISO-abbreviation] Prax Kinderpsychol Kinderpsychiatr
  • [Language] ger
  • [Publication-type] English Abstract; Historical Article; Journal Article
  • [Publication-country] Germany
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41. Viñas Poch F, Jané Ballabriga MC, Canals Sans J, Esparó Hidalgo G, Ballespí Solà S, Doménech-Llaberia E: [Assessment of psychopathology in preschool age children through the Early Childhood Inventory-4 (ECI-4): agreement among parents and teachers]. Psicothema; 2008 Aug;20(3):481-6
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  • [Title] [Assessment of psychopathology in preschool age children through the Early Childhood Inventory-4 (ECI-4): agreement among parents and teachers].
  • [Transliterated title] Evaluación de la psicopatología del preescolar mediante el Early Childhood Inventory-4 (ECI-4): concordancia entre padres y maestros.
  • The main purpose of this study is to determine the level of agreement among parents and teachers as informants in each one of the dimensions or diagnostic categories of the Early Childhood Inventory-4 (ECI-4).
  • [MeSH-minor] Child. Child, Preschool. Diagnostic and Statistical Manual of Mental Disorders. Female. Humans. Male. Observer Variation. Prevalence

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  • (PMID = 18674447.001).
  • [ISSN] 0214-9915
  • [Journal-full-title] Psicothema
  • [ISO-abbreviation] Psicothema
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] Spain
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42. Meeker ND, Yang JJ, Schiffman JD: Pharmacogenomics of pediatric acute lymphoblastic leukemia. Expert Opin Pharmacother; 2010 Jul;11(10):1621-32
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  • [Title] Pharmacogenomics of pediatric acute lymphoblastic leukemia.
  • IMPORTANCE OF THE FIELD: Pediatric acute lymphoblastic leukemia (ALL) represents one of the best examples of progress in disease treatment and improved outcome based in part upon the incorporation of the principles of pharmacogenomics.
  • Throughout the past several decades, clinical scientists have continued to refine risk stratification in clinical trials with the understanding that individual patients have different subtypes of pediatric ALL that will respond to therapy in different, but predictable ways.
  • AREAS COVERED IN THIS REVIEW: Discussed in this review are the most significant findings from pharmacogenomic studies of pediatric ALL from 1989 to the present.
  • Pharmacogenomic studies related to the drugs commonly used to treat pediatric ALL are covered in detail, including an emphasis on both genome-wide and candidate gene/pathway approaches.
  • TAKE HOME MESSAGE: The outcome for children with pediatric ALL has improved greatly, and this is in part due to the successful integration of data from pharmacogenomic studies into clinical trials.
  • [MeSH-major] Pharmacogenetics. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • [MeSH-minor] Child. Cytochrome P-450 CYP3A / genetics. Glucocorticoids / therapeutic use. Humans. Methotrexate / therapeutic use. Methyltransferases / genetics. Neoplasm, Residual. Vincristine / therapeutic use

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  • (PMID = 20429672.001).
  • [ISSN] 1744-7666
  • [Journal-full-title] Expert opinion on pharmacotherapy
  • [ISO-abbreviation] Expert Opin Pharmacother
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Glucocorticoids; 5J49Q6B70F / Vincristine; EC 1.14.14.1 / CYP3A5 protein, human; EC 1.14.14.1 / Cytochrome P-450 CYP3A; EC 2.1.1.- / Methyltransferases; EC 2.1.1.67 / thiopurine methyltransferase; YL5FZ2Y5U1 / Methotrexate
  • [Number-of-references] 120
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43. Gansz B, Ständer S, Metze D: [Acral pseudolymphomatous angiokeratoma of children (APACHE)]. Hautarzt; 2005 Mar;56(3):270-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Akrale pseudolymphomatöse Angiokeratome der Kindheit (APACHE).

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  • (PMID = 15580454.001).
  • [ISSN] 0017-8470
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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44. Sadawaite S, Jijina F, Nair CK, Seth S, Ghosh K: An unusual presentation of pediatric acute lymphoblastic leukemia. Indian J Hematol Blood Transfus; 2008 Jun;24(2):59-62

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An unusual presentation of pediatric acute lymphoblastic leukemia.
  • Acute lymphoblastic leukemia (ALL) is one of the most common hematological malignancies occurring in children.
  • Pediatric ALL patients usually present with symptoms due to cytopenias, fever and bone pains.

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  • [Cites] Arch Dis Child. 1977 Jul;52(7):530-3 [267448.001]
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  • (PMID = 23100945.001).
  • [ISSN] 0971-4502
  • [Journal-full-title] Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion
  • [ISO-abbreviation] Indian J Hematol Blood Transfus
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3453041
  • [Keywords] NOTNLM ; ALL / Fracture / Osteoporosis
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45. Işik N, Balak N, Silav G, Elmaci I: Pediatric intramedullary teratomas. Neuropediatrics; 2008 Aug;39(4):196-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pediatric intramedullary teratomas.
  • Teratomas account for 3% of all childhood tumors, with the majority occurring in the sacrococcygeal region and in the ovary.
  • [MeSH-minor] Child, Preschool. Female. Humans. Magnetic Resonance Imaging

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  • (PMID = 19165706.001).
  • [ISSN] 0174-304X
  • [Journal-full-title] Neuropediatrics
  • [ISO-abbreviation] Neuropediatrics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 37
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46. Lightfoot T: Aetiology of childhood leukemia. Bioelectromagnetics; 2005;Suppl 7:S5-S11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aetiology of childhood leukemia.
  • Leukemia is the most common cancer to affect children, accounting for approximately a third of all childhood cancers.
  • The major morphological subtypes of leukemia, acute lymphoblastic leukemia (ALL), and acute myeloblastic leukemia (AML), are characterized by chromosomal translocations involving over 200 genes including mixed lineage leukemia (MLL), TEL, and AML1.
  • Chromosomal translocations involving the MLL gene at 11q23 are a common feature of infant acute leukemia, found in up to 80% of all cases, and there is strong evidence that rearrangements involving the MLL gene or the TEL-AML1 gene fusion can originate in utero.
  • As with most other cancers, the mechanism by which leukemia arises is likely to involve gene-environment interactions.
  • Exposures acting before birth and early in life has long been thought to be important determinants of leukemia, and the list of suspected chemical, physical, and biological agents continues to increase.
  • Unfortunately, the evidence regarding the majority of suggested exposures is limited and often contradictory, and there are areas, which clearly warrant further investigation in order to further our understanding of the aetiology of childhood leukemia.
  • [MeSH-major] Electromagnetic Fields / adverse effects. Environmental Exposure / adverse effects. Leukemia, Radiation-Induced / etiology. Leukemia, Radiation-Induced / physiopathology. Prenatal Exposure Delayed Effects / etiology. Prenatal Exposure Delayed Effects / physiopathology
  • [MeSH-minor] Child. Child, Preschool. Female. Humans. Infant. Infant, Newborn. Models, Biological. Pregnancy. Risk Assessment / methods. Risk Factors

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc
  • (PMID = 16059922.001).
  • [ISSN] 0197-8462
  • [Journal-full-title] Bioelectromagnetics
  • [ISO-abbreviation] Bioelectromagnetics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 54
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47. Styczynski J, Kurylak A, Wysocki M: Cytotoxicity of cortivazol in childhood acute lymphoblastic leukemia. Anticancer Res; 2005 May-Jun;25(3B):2253-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytotoxicity of cortivazol in childhood acute lymphoblastic leukemia.
  • BACKGROUND: Glucocorticoids are the most important group of drugs used in the treatment of childhood acute lymphoblastic leukemia (ALL), however, resistance to this group remains the main obstacle in curing the disease.
  • AIM: Analysis of ex vivo sensitivity to cortivazol and other glucocorticoids in childhood acute lymphoblastic leukemia, as well as the relationship to anticancer therapy outcome.
  • CONCLUSION: Cortivazol has potent antileukemic activity in childhood ALL.
  • [MeSH-major] Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Pregnatrienes / pharmacology
  • [MeSH-minor] Adolescent. Cell Cycle / drug effects. Child. Child, Preschool. Drug Resistance, Neoplasm. Female. Glucocorticoids / pharmacology. Humans. Infant. Lymphocytes / drug effects. Lymphocytes / pathology. Male. Prednisolone / pharmacology. Prognosis

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  • (PMID = 16158972.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Glucocorticoids; 0 / Pregnatrienes; 9PHQ9Y1OLM / Prednisolone; YM183K0H63 / cortivazol
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48. Jamroziak K, Robak T: Do polymorphisms in ABC transporter genes influence risk of childhood acute lymphoblastic leukemia? Leuk Res; 2008 Aug;32(8):1173-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Do polymorphisms in ABC transporter genes influence risk of childhood acute lymphoblastic leukemia?
  • It is widely accepted that pathogenesis of childhood acute lymphoblastic leukemia (ALL) is related to the interplay between specific environmental exposure and inherited background.
  • Here, we review several recent reports on potential association between single nucleotide polymorphisms (SNPs) in genes encoding for ABC transporters with predisposition to pediatric ALL.
  • [MeSH-major] ATP-Binding Cassette Transporters / genetics. Polymorphism, Single Nucleotide. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • [MeSH-minor] Child. Child, Preschool. Genetic Predisposition to Disease. Humans. P-Glycoprotein / genetics

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  • [CommentOn] Leuk Res. 2008 Aug;32(8):1214-20 [18243305.001]
  • (PMID = 18294687.001).
  • [ISSN] 0145-2126
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Comment; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / P-Glycoprotein
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49. Aplenc R, Thompson J, Han P, La M, Zhao H, Lange B, Rebbeck T: Methylenetetrahydrofolate reductase polymorphisms and therapy response in pediatric acute lymphoblastic leukemia. Cancer Res; 2005 Mar 15;65(6):2482-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Methylenetetrahydrofolate reductase polymorphisms and therapy response in pediatric acute lymphoblastic leukemia.
  • A significant portion of patients treated for pediatric acute lymphoblastic leukemia (ALL) relapse.
  • Methotrexate (MTX), which interrupts folate metabolism, is a mainstay of pediatric ALL therapy.
  • These data provide evidence that the MTHFR C677T polymorphism is a common genetic variant conferring a moderate relative risk and a high attributable risk for relapse in pediatric ALL patients.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Methotrexate / therapeutic use. Methylenetetrahydrofolate Reductase (NADPH2) / genetics. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Precursor Cell Lymphoblastic Leukemia-Lymphoma / enzymology
  • [MeSH-minor] Alleles. Case-Control Studies. Child, Preschool. Female. Humans. Male. Polymorphism, Genetic


50. Lowas SR, Marks D, Malempati S: Prevalence of transient hyperglycemia during induction chemotherapy for pediatric acute lymphoblastic leukemia. Pediatr Blood Cancer; 2009 Jul;52(7):814-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prevalence of transient hyperglycemia during induction chemotherapy for pediatric acute lymphoblastic leukemia.
  • BACKGROUND: Transient hyperglycemia (TH) is a recognized side effect of the corticosteroids and asparaginase given during induction chemotherapy for pediatric acute lymphoblastic leukemia (ALL).
  • This study examined the prevalence of TH in a cohort of pediatric ALL patients and the impact on TH of type of steroid or asparaginase used and of risk factors such as age, gender, and overweight.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / adverse effects. Hyperglycemia / chemically induced. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • [MeSH-minor] Adolescent. Asparaginase / administration & dosage. Body Mass Index. Child. Child, Preschool. Cohort Studies. Dexamethasone / administration & dosage. Female. Humans. Male. Polyethylene Glycols / administration & dosage. Prednisone / administration & dosage. Prevalence. Remission Induction. Retrospective Studies. Risk Factors

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19260096.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / pegaspargase; 30IQX730WE / Polyethylene Glycols; 7S5I7G3JQL / Dexamethasone; EC 3.5.1.1 / Asparaginase; VB0R961HZT / Prednisone
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51. Sinnett D, Labuda D, Krajinovic M: Challenges identifying genetic determinants of pediatric cancers--the childhood leukemia experience. Fam Cancer; 2006;5(1):35-47
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Challenges identifying genetic determinants of pediatric cancers--the childhood leukemia experience.
  • Pediatric cancers affect approximately 1 in every 500 children before the age of 15.
  • Because of its relatively high prevalence, most of the work done in pediatric oncogenetics has been focused on leukemias, particularly acute lymphoblastic leukemia (ALL).
  • Although it is now well accepted that genetic variation plays a significant role in determining individual's cancer susceptibility, few studies have explored genetic susceptibility to childhood leukemia with respect to common polymorphisms.
  • To evaluate whether candidate genes in these pathways are involved in childhood leukemogenesis, we conducted case-control studies.
  • We also observed that, at least at some loci, the parental genetics might be important in predicting the risk of cancer in this pediatric model of a complex disease.
  • Taken together, these results indicate that the investigation of a single enzyme and/or a single genotype might not be sufficient to explain the etiology of childhood leukemia because of the complexity of the environment and that of the inter-individual variability in cancer susceptibility.
  • [MeSH-major] Cytochrome P-450 Enzyme System / genetics. Genetic Predisposition to Disease / epidemiology. Glutathione Transferase / genetics. Oxidative Stress / physiology. Polymorphism, Genetic. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • [MeSH-minor] Child. Child, Preschool. Confidence Intervals. Female. Gene Expression Regulation, Neoplastic. Genotype. Humans. Incidence. Male. Odds Ratio. Pediatrics. Pedigree. Prognosis. Risk Assessment

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  • (PMID = 16528607.001).
  • [ISSN] 1389-9600
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 9035-51-2 / Cytochrome P-450 Enzyme System; EC 2.5.1.18 / Glutathione Transferase
  • [Number-of-references] 136
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52. Sinnett D, N'Diaye N, Labuda D, Krajinovic M: [Genetic determinants of childhood leukemia]. Bull Cancer; 2006 Sep;93(9):857-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Genetic determinants of childhood leukemia].
  • [Transliterated title] Les déterminants génétiques de la leucémie de l'enfant.
  • Pediatric cancers affect approximately 1 in every 500 children before the age of 15.
  • Because of its relatively high prevalence, most of the work done in pediatric oncogenetics has been focused on leukemias, particularly acute lymphoblastic leukemia (ALL).
  • Although it is now well accepted that genetic variations play a significant role in determining individual's cancer susceptibility, few studies have explored genetic susceptibility to childhood leukemia with respect to common polymorphisms.
  • To evaluate whether candidate genes in these pathways are involved in childhood leukemogenesis, we conducted association studies.
  • We also observed that, at least at some loci, the parental genetics might be important in predicting the risk of cancer in this pediatric model of a complex disease.
  • Taken together, these results indicate that the investigation of a single enzyme and/or a single genotype might not be sufficient to explain the etiology of childhood leukemia because of the complexity of the environment and that of the inter-individual variability in cancer susceptibility.
  • [MeSH-major] Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • [MeSH-minor] Adolescent. Carcinogens / metabolism. Child. Cytochrome P-450 Enzyme System / genetics. Cytochrome P-450 Enzyme System / metabolism. Environment. Female. Folic Acid / metabolism. Genetic Predisposition to Disease. Glutathione Transferase / genetics. Glutathione Transferase / metabolism. Humans. Male. Maternal Exposure / adverse effects. Oxidative Stress. Paternal Exposure / adverse effects

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  • (PMID = 16980228.001).
  • [ISSN] 1769-6917
  • [Journal-full-title] Bulletin du cancer
  • [ISO-abbreviation] Bull Cancer
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Carcinogens; 9035-51-2 / Cytochrome P-450 Enzyme System; 935E97BOY8 / Folic Acid; EC 2.5.1.18 / Glutathione Transferase
  • [Number-of-references] 65
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53. Zweidler-McKay PA: Notch signaling in pediatric malignancies. Curr Oncol Rep; 2008 Nov;10(6):459-68
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Notch signaling in pediatric malignancies.
  • Because many pediatric malignancies arise from dysregulated development, roles for Notch signaling in these cancers are to be expected.
  • Evidence to support this is now emerging as the Notch pathway is being explored in more pediatric cancers.
  • As examples, although activating mutations of Notch1 are found in the majority of T-cell acute lymphoblastic leukemia (ALL) cases, Notch/HES1 signaling appears to play a tumor suppressor role in precursor B-cell ALL; although Notch/HES1 signaling appears to contribute to osteosarcoma metastasis, Notch signaling also promotes medulloblastoma "stem cell" survival and contributes to angiogenesis in neuroblastoma.
  • Further understanding of the roles of Notch signaling in specific pediatric cancers will provide a rationale for Notch-based therapeutic strategies.
  • [MeSH-minor] Animals. Cell Lineage. Cell Survival. Child. Genes, Tumor Suppressor. Humans. Mutation. Neoplasm Metastasis. Osteosarcoma / therapy. Signal Transduction. Stem Cells / cytology

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  • (PMID = 18928660.001).
  • [ISSN] 1534-6269
  • [Journal-full-title] Current oncology reports
  • [ISO-abbreviation] Curr Oncol Rep
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Notch
  • [Number-of-references] 50
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54. Whitley E, Gunnell D, Davey Smith G, Holly JM, Martin RM: Childhood circumstances and anthropometry: the Boyd Orr cohort. Ann Hum Biol; 2008 Sep-Oct;35(5):518-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Childhood circumstances and anthropometry: the Boyd Orr cohort.
  • BACKGROUND: Childhood environment is known to affect stature in childhood and adulthood.
  • Peak growth for different anthropometric measures occurs at different times and so associations with childhood conditions that vary across different components of stature may indicate periods of growth that are particularly influenced by environmental factors.
  • METHODS: The study examined relationships between anthropometric measurements (foot length, shoulder breadth, height, trunk and leg length) and childhood exposures (breast-feeding, birth order, household income, household food expenditure, social class, crowding, number of children in the household, and household diet) in 2376 members of the Boyd Orr cohort aged 2-14 years.
  • RESULTS: All childhood exposures were associated with childhood anthropometric measures to some degree.
  • CONCLUSIONS: The individual components of stature most strongly associated with childhood environment in this age group were leg and foot length.
  • [MeSH-minor] Adolescent. Age Distribution. Child. Child, Preschool. Cohort Studies. Confidence Intervals. Female. Health Surveys. Humans. Male. Sex Characteristics

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  • (PMID = 18821329.001).
  • [ISSN] 1464-5033
  • [Journal-full-title] Annals of human biology
  • [ISO-abbreviation] Ann. Hum. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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55. Okamoto R, Ogawa S, Nowak D, Kawamata N, Akagi T, Kato M, Sanada M, Weiss T, Haferlach C, Dugas M, Ruckert C, Haferlach T, Koeffler HP: Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia. Haematologica; 2010 Sep;95(9):1481-8
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  • [Title] Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia.
  • BACKGROUND: Differences in survival have been reported between pediatric and adult acute lymphoblastic leukemia.
  • The inferior prognosis in adult acute lymphoblastic leukemia is not fully understood but could be attributed, in part, to differences in genomic alterations found in adult as compared to in pediatric acute lymphoblastic leukemia.
  • DESIGN AND METHODS: We compared two different sets of high-density single nucleotide polymorphism array genotyping data from 75 new diagnostic adult and 399 previously published diagnostic pediatric acute lymphoblastic leukemia samples.
  • RESULTS: The high density single nucleotide polymorphism array analysis of 75 samples of adult acute lymphoblastic leukemia led to the identification of numerous cryptic and submicroscopic genomic lesions with a mean of 7.6 genomic alterations per sample.
  • The patterns and frequencies of lesions detected in the adult samples largely reproduced known genomic hallmarks detected in previous single nucleotide polymorphism-array studies of pediatric acute lymphoblastic leukemia, such as common deletions of 3p14.2 (FHIT), 5q33.3 (EBF), 6q, 9p21.3 (CDKN2A/B), 9p13.2 (PAX5), 13q14.2 (RB1) and 17q11.2 (NF1).
  • Some differences between adult and pediatric acute lymphoblastic leukemia were identified when the pediatric data set was partitioned into hyperdiploid and non-hyperdiploid cases and then compared to the nearly exclusively non-hyperdiploid adult samples.
  • CONCLUSIONS: Our analysis of adult acute lymphoblastic leukemia cases led to the identification of new potential target lesions relevant for the pathogenesis of acute lymphoblastic leukemia.
  • However, no unequivocal pattern of submicroscopic genomic alterations was found to separate adult acute lymphoblastic leukemia from pediatric acute lymphoblastic leukemia.
  • Therefore, apart from different therapy regimen, differences of prognosis between adult and pediatric acute lymphoblastic leukemia are probably based on genetic subgroups according to cytogenetically detectable lesions but not focal genomic copy number microlesions.

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  • (PMID = 20435627.001).
  • [ISSN] 1592-8721
  • [Journal-full-title] Haematologica
  • [ISO-abbreviation] Haematologica
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA026038-31; United States / NCI NIH HHS / CA / R01 CA026038-32; United States / NCI NIH HHS / CA / CA026038-30A2; United States / NCI NIH HHS / CA / R01 CA026038; United States / NCI NIH HHS / CA / R01 CA026038-30A2
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2930948
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56. Levine RL: Inherited susceptibility to pediatric acute lymphoblastic leukemia. Nat Genet; 2009 Sep;41(9):957-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Inherited susceptibility to pediatric acute lymphoblastic leukemia.
  • Although genome-wide analyses have identified somatic alterations contributing to the pathogenesis of pediatric acute lymphoblastic leukemia (ALL), few studies have identified germline variants conferring risk of this disease.
  • [MeSH-major] Genetic Predisposition to Disease. Precursor Cell Lymphoblastic Leukemia-Lymphoma / etiology
  • [MeSH-minor] Alleles. CCAAT-Enhancer-Binding Proteins / genetics. Case-Control Studies. Cell Line, Transformed. Cell Transformation, Viral. Child. Child, Preschool. Cohort Studies. Core Binding Factor Alpha 2 Subunit / genetics. DNA-Binding Proteins / genetics. Gene Frequency. Genetic Variation. Genome-Wide Association Study. Germ-Line Mutation. Haplotypes. Herpesvirus 4, Human / physiology. Humans. Ikaros Transcription Factor / genetics. Oncogene Proteins, Fusion / genetics. Polymorphism, Single Nucleotide. Risk Factors. Transcription Factors / genetics

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  • (PMID = 19710713.001).
  • [ISSN] 1546-1718
  • [Journal-full-title] Nature genetics
  • [ISO-abbreviation] Nat. Genet.
  • [Language] eng
  • [Publication-type] News
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ARID5B protein, human; 0 / CCAAT-Enhancer-Binding Proteins; 0 / Core Binding Factor Alpha 2 Subunit; 0 / DNA-Binding Proteins; 0 / IKZF1 protein, human; 0 / Oncogene Proteins, Fusion; 0 / TEL-AML1 fusion protein; 0 / Transcription Factors; 142805-41-2 / CEBPE protein, human; 148971-36-2 / Ikaros Transcription Factor
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57. Janzen LA, Spiegler BJ: Neurodevelopmental sequelae of pediatric acute lymphoblastic leukemia and its treatment. Dev Disabil Res Rev; 2008;14(3):185-95
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neurodevelopmental sequelae of pediatric acute lymphoblastic leukemia and its treatment.
  • This review will describe the neurocognitive outcomes associated with pediatric acute lymphoblastic leukemia (ALL) and its treatment.
  • Preventing or ameliorating treatment-related neuropsychological sequelae represents the next major challenge in pediatric ALL.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / adverse effects. Brain Damage, Chronic / chemically induced. Cognition Disorders / chemically induced. Developmental Disabilities / chemically induced. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Survivors / psychology
  • [MeSH-minor] Adolescent. Adult. Brain / drug effects. Brain / radiation effects. Child. Child, Preschool. Combined Modality Therapy. Cranial Irradiation. Humans. Infant. Prognosis. Radiation Injuries / diagnosis. Radiation Injuries / psychology. Treatment Outcome. Young Adult

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18924154.001).
  • [ISSN] 1940-5529
  • [Journal-full-title] Developmental disabilities research reviews
  • [ISO-abbreviation] Dev Disabil Res Rev
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 120
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58. Wu P, Feng K, Li J, Xie Z, Xue P, Cai T, Cui Z, Chen X, Hou J, Zhang J, Yang F: Discovery and identification of potential biomarkers of pediatric acute lymphoblastic leukemia. Proteome Sci; 2009 Mar 16;7:7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Discovery and identification of potential biomarkers of pediatric acute lymphoblastic leukemia.
  • BACKGROUND: Acute lymphoblastic leukemia (ALL) is a common form of cancer in children.
  • Noninvasive biomarkers for the early diagnosis of pediatric ALL are urgently needed.
  • The aim of this study was to discover potential protein biomarkers for pediatric ALL.
  • METHODS: Ninety-four pediatric ALL patients and 84 controls were randomly divided into a "training" set (45 ALL patients, 34 healthy controls) and a test set (49 ALL patients, 30 healthy controls and 30 pediatric acute myeloid leukemia (AML) patients).
  • RESULTS: A total of 7 protein peaks (9290 m/z, 7769 m/z, 15110 m/z, 7564 m/z, 4469 m/z, 8937 m/z, 8137 m/z) were found with differential expression levels in the sera of pediatric ALL patients and controls using SELDI-TOF-MS and then analyzed by BPS to construct a classification model in the "training" set.
  • Two candidate protein peaks (7769 and 9290 m/z) were found to be down-regulated in ALL patients, where these were identified as platelet factor 4 (PF4) and pro-platelet basic protein precursor (PBP).
  • CONCLUSION: Platelet factor (PF4), connective tissue activating peptide III (CTAP-III) and two fragments of C3a may be potential protein biomarkers of pediatric ALL and used to distinguish pediatric ALL patients from healthy controls and pediatric AML patients.
  • Further studies with additional populations or using pre-diagnostic sera are needed to confirm the importance of these findings as diagnostic markers of pediatric ALL.

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  • [Cites] Cancer. 2006 Apr 1;106(7):1587-94 [16518825.001]
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  • (PMID = 19291297.001).
  • [ISSN] 1477-5956
  • [Journal-full-title] Proteome science
  • [ISO-abbreviation] Proteome Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2662805
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59. Jain N, Brouwers P, Okcu MF, Cirino PT, Krull KR: Sex-specific attention problems in long-term survivors of pediatric acute lymphoblastic leukemia. Cancer; 2009 Sep 15;115(18):4238-45
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sex-specific attention problems in long-term survivors of pediatric acute lymphoblastic leukemia.
  • BACKGROUND: Neurocognitive problems are a frequent outcome of chemotherapy for pediatric leukemia, although individual differences exist in patient outcome.
  • The purpose of this study was to evaluate the pattern of attention problems in male and female long-term survivors of pediatric acute lymphoblastic leukemia (ALL).
  • CONCLUSIONS: The results of this study suggest that children diagnosed with and treated for pediatric ALL perform poorly on select measures of attention and executive control, and that this performance is influenced by sex and treatment intensity.
  • [MeSH-major] Attention. Cognition Disorders / etiology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / psychology. Sex Characteristics. Survivors / psychology
  • [MeSH-minor] Age of Onset. Child. Female. Humans. Male

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  • [Copyright] Copyright (c) 2009 American Cancer Society.
  • (PMID = 19536898.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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60. Riedt T, Ebinger M, Salih HR, Tomiuk J, Handgretinger R, Kanz L, Grünebach F, Lengerke C: Aberrant expression of the homeobox gene CDX2 in pediatric acute lymphoblastic leukemia. Blood; 2009 Apr 23;113(17):4049-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aberrant expression of the homeobox gene CDX2 in pediatric acute lymphoblastic leukemia.
  • Consistent with the notion that embryonic pathways can reactivate during adult oncogenesis, recent studies suggest involvement of CDX2 in human acute myeloid leukemia (AML).
  • Here we study CDX2 in healthy and leukemic human lymphoid cells, and show that a majority of leukemic samples display various degrees of aberrant CDX2 expression.
  • Analysis of a cohort of 37 childhood acute lymphoblastic leukemia (ALL) patients treated in our hospital reveals that high CDX2 expression levels at diagnosis correlate with persistence of minimal residual disease (MRD) during the course of treatment.
  • Thus, CDX2 expression levels may serve as a marker for adverse prognosis in pediatric ALL.
  • [MeSH-major] Gene Expression Regulation, Neoplastic / genetics. Homeodomain Proteins / metabolism. Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism
  • [MeSH-minor] Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Case-Control Studies. Child. Humans. Transcription, Genetic / genetics

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  • (PMID = 19218548.001).
  • [ISSN] 1528-0020
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins
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61. Kulkarni KP, Marwaha RK: Pattern and implications of therapy abandonment in childhood acute lymphoblastic leukemia. Asian Pac J Cancer Prev; 2010;11(5):1435-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pattern and implications of therapy abandonment in childhood acute lymphoblastic leukemia.
  • In this communication we describe the pattern of therapy abandonment and its impact on survival of childhood acute lymphoblastic leukemia at a large tertiary care center in Northern India and discuss remedial measures.
  • [MeSH-major] Medication Therapy Management. Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy. Treatment Refusal. Withholding Treatment

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  • (PMID = 21198307.001).
  • [ISSN] 2476-762X
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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62. Hasanbegovic E, Mehadzic S: [Etiology of lymphadenopathy in childhood]. Med Glas (Zenica); 2010 Aug;7(2):132-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Etiology of lymphadenopathy in childhood].
  • METHODS: One hundred and fifteen children aged 0-15 years with diagnosed lymphadenopathy at the Pediatric Clinic in Sarajevo during 2008 were included in the study.
  • Most frequent causes of malignant lymphadenopathy were acute lymphoblastic leukemia in 11 children (55 %) and acute myeloid leukemia in two (10%) children.
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Humans. Infant. Male

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  • (PMID = 21258308.001).
  • [ISSN] 1840-0132
  • [Journal-full-title] Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina
  • [ISO-abbreviation] Med Glas (Zenica)
  • [Language] bos
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Bosnia and Herzegovina
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63. Kuhn A, Hanneken S, Megahed M, Ruzicka T, Neumann NJ: [Extreme photosensitivity since childhood]. Hautarzt; 2006 Jan;57(1):56-8, 60

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Extreme photosensitivity since childhood].
  • [Transliterated title] Extreme Photosensitivität seit der Kindheit.

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  • [Cites] Br J Dermatol. 2001 Feb;144(2):292-6 [11251561.001]
  • [Cites] Hautarzt. 2003 Oct;54(10):977-9 [14513247.001]
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  • (PMID = 16440239.001).
  • [ISSN] 0017-8470
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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64. Yang YL, Lin SR, Chen JS, Lin SW, Yu SL, Chen HY, Yen CT, Lin CY, Lin JF, Lin KH, Jou ST, Hu CY, Chang SK, Lu MY, Chang HH, Chang WH, Lin KS, Lin DT: Expression and prognostic significance of the apoptotic genes BCL2L13, Livin, and CASP8AP2 in childhood acute lymphoblastic leukemia. Leuk Res; 2010 Jan;34(1):18-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression and prognostic significance of the apoptotic genes BCL2L13, Livin, and CASP8AP2 in childhood acute lymphoblastic leukemia.
  • Improved treatment of childhood acute lymphoblastic leukemia (ALL) depends on the identification of new molecular markers that are able to predict treatment response and clinical outcome.
  • We investigated the expression of three apoptosis related genes, BCL2L13, CASP8AP2, and Livin, as well as their prognostic significance, in a retrospective study of 90 pediatric ALL patients diagnosed between 1996 and 2007 in Taiwan.
  • Multivariate analysis for EFS and OS demonstrated that high expression of BCL2L13 was an independent prognostic factor for childhood ALL in this ethnic group.
  • [MeSH-major] Adaptor Proteins, Signal Transducing / genetics. Apoptosis / genetics. Apoptosis Regulatory Proteins / genetics. Calcium-Binding Proteins / genetics. Inhibitor of Apoptosis Proteins / genetics. Neoplasm Proteins / genetics. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics. Proto-Oncogene Proteins c-bcl-2 / genetics
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Humans. Infant. Infant, Newborn. Male. Prognosis. Proportional Hazards Models. Reverse Transcriptase Polymerase Chain Reaction

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  • [Copyright] 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 20109966.001).
  • [ISSN] 1873-5835
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Apoptosis Regulatory Proteins; 0 / BCL2L13 protein, human; 0 / BIRC7 protein, human; 0 / CASP8AP2 protein, human; 0 / Calcium-Binding Proteins; 0 / Inhibitor of Apoptosis Proteins; 0 / Neoplasm Proteins; 0 / Proto-Oncogene Proteins c-bcl-2
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65. Unal S, Cetin M, Tuncer AM, Gümrük F, Yetgin S: The prognostic impact of myeloid antigen expression in pediatric acute lymphoblastic leukemia patients. Turk J Pediatr; 2008 Nov-Dec;50(6):533-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The prognostic impact of myeloid antigen expression in pediatric acute lymphoblastic leukemia patients.
  • The incidence of mixed-lineage leukemias in the pediatric age group was previously reported as 13.8% for myeloid antigen-positive ALL and 11.1% for lymphoid antigen-positive acute myeloid leukemia (AML).
  • Our study also supports most of the previous data and we postulate that myeloid antigen expression in pediatric ALL cases has insignificant effect on clinical presentation, relapse rates and survival.
  • [MeSH-major] Antigens, CD / immunology. Antigens, Differentiation, Myelomonocytic / immunology. Antigens, Neoplasm / immunology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Flow Cytometry. Humans. Immunophenotyping. Male. Prognosis. Retrospective Studies. Survival Rate

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  • (PMID = 19227415.001).
  • [ISSN] 0041-4301
  • [Journal-full-title] The Turkish journal of pediatrics
  • [ISO-abbreviation] Turk. J. Pediatr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Antigens, Neoplasm
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66. Dunwell TL, Hesson LB, Pavlova T, Zabarovska V, Kashuba V, Catchpoole D, Chiaramonte R, Brini AT, Griffiths M, Maher ER, Zabarovsky E, Latif F: Epigenetic analysis of childhood acute lymphoblastic leukemia. Epigenetics; 2009 Apr 1;4(3):185-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epigenetic analysis of childhood acute lymphoblastic leukemia.
  • We used a chromosome 3 wide NotI microarray for identification of epigenetically inactivated genes in childhood acute lymphoblastic leukemia (ALL).
  • Three novel genes demonstrated frequent methylation in childhood ALL.
  • In our series of childhood ALL BNC1 was frequently methylated in both T (77%) and B-ALL (79%), whilst MSX1 showed T-ALL (25%) specific methylation.
  • The methylation of the above five genes was cancer specific and expression of the genes could be restored in methylated leukemia cell lines treated with 5-aza-2'-deoxycytidine.
  • This is the first report demonstrating frequent epigenetic inactivation of PPP2R3A, FBLN2, THRB, BNC1 and MSX1 in leukemia.
  • [MeSH-major] Chromosomes, Human, Pair 3 / genetics. DNA Methylation. Epigenesis, Genetic. Gene Expression Regulation, Leukemic. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics


67. Nathan PC, Wasilewski-Masker K, Janzen LA: Long-term outcomes in survivors of childhood acute lymphoblastic leukemia. Hematol Oncol Clin North Am; 2009 Oct;23(5):1065-82, vi-vii
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term outcomes in survivors of childhood acute lymphoblastic leukemia.
  • Cure rates for childhood acute lymphoblastic leukemia (ALL) now exceed 80%.
  • Consequently, there is a growing population of survivors of childhood ALL who are at risk for developing late sequelae of their cancer therapy.
  • In this article, the more common, serious late effects of ALL therapy are reviewed, the treatment exposures that predispose some survivors to their development are discussed, and the need for life-long risk-based medical care for all survivors of childhood ALL is emphasized.
  • [MeSH-major] Precursor Cell Lymphoblastic Leukemia-Lymphoma / mortality. Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
  • [MeSH-minor] Child. Humans. Survivors. Time Factors. Treatment Outcome


68. Udayakumar AM, Bashir WA, Pathare AV, Wali YA, Zacharia M, Khan AA, Soliman H, Al-Lamki Z, Raeburn JA: Cytogenetic profile of childhood acute lymphoblastic leukemia in Oman. Arch Med Res; 2007 Apr;38(3):305-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytogenetic profile of childhood acute lymphoblastic leukemia in Oman.
  • BACKGROUND: Chromosomal abnormalities have important diagnostic and prognostic significance in acute lymphoblastic leukemia (ALL).
  • The purpose of this study was to define and classify the frequency and type of chromosomal abnormalities among newly diagnosed children with ALL and compare the results with those reported from other geographical regions of the world.
  • METHODS: Bone marrow chromosomal studies with GTG banding were performed in untreated ALL pediatric patients aged from 7 days to 14 years.
  • To our knowledge, this is the first report from the Middle East of a cytogenetic study on childhood ALL.
  • [MeSH-major] Chromosome Aberrations. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Cytogenetics. Female. Humans. Immunophenotyping. Infant. Infant, Newborn. Male. Oman. Ploidies

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  • (PMID = 17350480.001).
  • [ISSN] 0188-4409
  • [Journal-full-title] Archives of medical research
  • [ISO-abbreviation] Arch. Med. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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69. Maecker B, Mougiakakos D, Zimmermann M, Behrens M, Hollander S, Schrauder A, Schrappe M, Welte K, Klein C: Dendritic cell deficiencies in pediatric acute lymphoblastic leukemia patients. Leukemia; 2006 Apr;20(4):645-9
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  • [Title] Dendritic cell deficiencies in pediatric acute lymphoblastic leukemia patients.
  • Acute lymphoblastic leukemia (ALL) cells are particularly poor at generating anti-leukemia immunity, despite residing in lymphoid organs.
  • To assess a potential role of dendritic cells (DC) in poor anti-leukemia immunity, we analyzed peripheral blood DC in 55 pediatric ALL patients at the time of initial diagnosis and 19 age-matched healthy controls.
  • Thus, depletion of DC in B-lineage ALL patients may contribute to poor anti-leukemia immune responses.
  • [MeSH-major] Antigens, CD11c / biosynthesis. Dendritic Cells / immunology. Lectins, C-Type / biosynthesis. Membrane Glycoproteins / biosynthesis. Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology. Receptors, Immunologic / biosynthesis
  • [MeSH-minor] Adolescent. Antigens, CD / biosynthesis. Antigens, CD13 / biosynthesis. Antigens, Differentiation, Myelomonocytic / biosynthesis. B-Lymphocytes / immunology. B-Lymphocytes / pathology. Cell Count. Child. Child, Preschool. Cohort Studies. Female. Flow Cytometry / methods. Humans. Immunophenotyping. Leukocyte Count. Male. Monocytes / pathology. Neutrophils / pathology. Peroxidase / biosynthesis. Sensitivity and Specificity. Sialic Acid Binding Ig-like Lectin 3

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  • (PMID = 16498391.001).
  • [ISSN] 0887-6924
  • [Journal-full-title] Leukemia
  • [ISO-abbreviation] Leukemia
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD11c; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD33 protein, human; 0 / CLEC4C protein, human; 0 / Lectins, C-Type; 0 / Membrane Glycoproteins; 0 / Receptors, Immunologic; 0 / Sialic Acid Binding Ig-like Lectin 3; EC 1.11.1.7 / Peroxidase; EC 3.4.11.2 / Antigens, CD13
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70. Soldin OP, Nsouli-Maktabi H, Genkinger JM, Loffredo CA, Ortega-Garcia JA, Colantino D, Barr DB, Luban NL, Shad AT, Nelson D: Pediatric acute lymphoblastic leukemia and exposure to pesticides. Ther Drug Monit; 2009 Aug;31(4):495-501
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  • [Title] Pediatric acute lymphoblastic leukemia and exposure to pesticides.
  • Organophosphates are pesticides ubiquitous in the environment and have been hypothesized as one of the risk factors for acute lymphoblastic leukemia (ALL).
  • In this study, we evaluated the associations of pesticide exposure in a residential environment with the risk for pediatric ALL.
  • This is a case-control study of children newly diagnosed with ALL, and their mothers (n = 41 child-mother pairs) recruited from Georgetown University Medical Center and Children's National Medical Center in Washington, DC, between January 2005 and January 2008.

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  • [ErratumIn] Ther Drug Monit. 2009 Oct;31(5):668. Nsouly-Maktabi, Hala [corrected to Nsouli-Maktabi, Hala]
  • (PMID = 19571777.001).
  • [ISSN] 1536-3694
  • [Journal-full-title] Therapeutic drug monitoring
  • [ISO-abbreviation] Ther Drug Monit
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / M01 RR020359; United States / NICHD NIH HHS / HD / U10 HD047890; United States / NCATS NIH HHS / TR / UL1 TR000101; United States / NICHD NIH HHS / HD / 5U10HD047890-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organophosphorus Compounds; 0 / Pesticides
  • [Other-IDs] NLM/ NIHMS444165; NLM/ PMC3622217
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71. Liu Y, Chen J, Tang J, Ni S, Xue H, Pan C: Cost of childhood acute lymphoblastic leukemia care in Shanghai, China. Pediatr Blood Cancer; 2009 Oct;53(4):557-62
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  • [Title] Cost of childhood acute lymphoblastic leukemia care in Shanghai, China.
  • BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most common and curable malignant pediatric disease in children.
  • Here, we analyzed the overall costs for pediatric ALL therapies and their constitutive elements.
  • Forty cases were B-lineage, four were T-lineage, and one was double-lymphoid lineage.
  • Average overall costs for childhood ALL in this study were less than US $11,000, with reasonable clinical results.
  • [MeSH-major] Health Care Costs. Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
  • [MeSH-minor] Adolescent. Child. Child, Preschool. China. Female. Humans. Infant. Male

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  • (PMID = 19526524.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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72. Robinson KE, Livesay KL, Campbell LK, Scaduto M, Cannistraci CJ, Anderson AW, Whitlock JA, Compas BE: Working memory in survivors of childhood acute lymphocytic leukemia: functional neuroimaging analyses. Pediatr Blood Cancer; 2010 Apr;54(4):585-90
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  • [Title] Working memory in survivors of childhood acute lymphocytic leukemia: functional neuroimaging analyses.
  • BACKGROUND: Research on the physical and psychological late effects of treatment of childhood cancer has led to the identification of significant long-term neurocognitive deficits experienced by some survivors, particularly in the areas of memory and executive functioning.
  • PROCEDURE: This study used functional neuroimaging techniques to examine working memory and executive functioning deficits of survivors of childhood acute lymphocytic leukemia (ALL), as compared to age- and gender-matched healthy controls.
  • CONCLUSIONS: These results support the theory of compensatory activation in necessary brain regions in order to complete tasks in pediatric ALL survivors, similar to that observed in multiple sclerosis patients.

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  • (PMID = 19953649.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA068485-13S4; United States / NCI NIH HHS / CA / P30 CA068485; United States / NCI NIH HHS / CA / CA068485; United States / NCI NIH HHS / CA / P30 CA068485-13S4
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 04079A1RDZ / Cytarabine; YL5FZ2Y5U1 / Methotrexate
  • [Other-IDs] NLM/ NIHMS183910; NLM/ PMC2901833
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73. Bachmann PS, Gorman R, Papa RA, Bardell JE, Ford J, Kees UR, Marshall GM, Lock RB: Divergent mechanisms of glucocorticoid resistance in experimental models of pediatric acute lymphoblastic leukemia. Cancer Res; 2007 May 1;67(9):4482-90
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  • [Title] Divergent mechanisms of glucocorticoid resistance in experimental models of pediatric acute lymphoblastic leukemia.
  • Cell line models of glucocorticoid resistance in childhood acute lymphoblastic leukemia (ALL) almost invariably exhibit altered glucocorticoid receptor (GR) function.
  • However, these findings are incongruous with those using specimens derived directly from leukemia patients, in which GR alterations are rarely found.
  • We present a novel paradigm of glucocorticoid resistance in childhood ALL, in which patient biopsies have been directly established as continuous xenografts in immune-deficient mice, without prior in vitro culture.
  • This finding contrasts with five commonly used leukemia cell lines, all of which exhibited defective GRE binding.
  • Furthermore, the receptor tyrosine kinase inhibitor, SU11657, completely reversed dexamethasone resistance in a xenograft expressing functional GR, indicating that pharmacologic reversal of glucocorticoid resistance in childhood ALL is achievable.
  • [MeSH-major] Dexamethasone / pharmacology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Receptors, Glucocorticoid / metabolism
  • [MeSH-minor] Animals. Apoptosis Regulatory Proteins / biosynthesis. Apoptosis Regulatory Proteins / genetics. Child. Gene Expression Regulation, Neoplastic. Humans. Membrane Proteins / biosynthesis. Membrane Proteins / genetics. Mice. Mice, Inbred NOD. Mice, SCID. Organic Chemicals / pharmacology. Proto-Oncogene Proteins / biosynthesis. Proto-Oncogene Proteins / genetics. Receptor Protein-Tyrosine Kinases / antagonists & inhibitors. Transcription Factors / biosynthesis. Transcription Factors / genetics. Transcription, Genetic. Xenograft Model Antitumor Assays

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  • (PMID = 17483364.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / Bcl-2-like protein 11; 0 / Membrane Proteins; 0 / Organic Chemicals; 0 / Proto-Oncogene Proteins; 0 / Receptors, Glucocorticoid; 0 / SU 11657; 0 / TSC22D3 protein, human; 0 / Transcription Factors; 7S5I7G3JQL / Dexamethasone; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases
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74. Watanabe A: [Recent advance in treatment of childhood acute lymphoblastic leukemia]. Gan To Kagaku Ryoho; 2007 Feb;34(2):150-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Recent advance in treatment of childhood acute lymphoblastic leukemia].
  • The five-year event-free survival of nearly 80% in childhood acute lymphoblastic leukemia (ALL) achieved in the 1990 s attested to the effectiveness of risk-directed therapy developed through well-designed clinical trials by 4 groups in clinical study, containing CCLSG, TCCSG, KYCCSG and JACLS.
  • Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) was organized in 2003 and includes all four clinical study groups in Japan.
  • The 2004 ALL protocol of Childhood Cancer and Leukemia Group in Japan (CCLSG) contained a new 2-step stratification based on initial age/WBC count and minimal residual disease at day 91.
  • [MeSH-major] Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
  • [MeSH-minor] Antineoplastic Protocols. Child. Child, Preschool. Humans. Infant. Leukocyte Count. Prognosis. Survival Rate

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  • (PMID = 17301519.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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75. Stanulla M, Schrappe M: Treatment of childhood acute lymphoblastic leukemia. Semin Hematol; 2009 Jan;46(1):52-63
Genetic Alliance. consumer health - Acute Lymphoblastic Leukemia, Childhood.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of childhood acute lymphoblastic leukemia.
  • Childhood acute lymphoblastic leukemia (ALL) is the most common malignancy of childhood.
  • Studies in ALL have been a model for clinical and basic research beyond pediatric hemato-oncology.
  • As a result of sustained and well-organized research efforts since the early 1960s, childhood ALL now can be successfully treated in about 80% of patients by the application of intensive combination chemotherapy regimens, which in specific patient subgroups may need to be supplemented with radiation therapy and/or hematopoietic stem cell transplantation.
  • Thus, future research must extend our molecular understanding of leukemia and host factors in order to even more specifically identify the mechanisms underlying the differences in treatment response and outcome, and to finally address the therapeutic needs of the individual child.
  • [MeSH-major] Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
  • [MeSH-minor] Child. Child, Preschool. Humans. Recurrence. Remission Induction. Treatment Outcome

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  • (PMID = 19100368.001).
  • [ISSN] 0037-1963
  • [Journal-full-title] Seminars in hematology
  • [ISO-abbreviation] Semin. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 101
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76. Golumbek P: Pharmacologic agents for pediatric neuroimmune disorders. Semin Pediatr Neurol; 2010 Dec;17(4):245-53
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  • [Title] Pharmacologic agents for pediatric neuroimmune disorders.
  • Autoimmune diseases make up a significant portion of the acute and chronic caseload of all pediatric neurologists.
  • This article provides an overview of the current therapeutic options as they relate to the more common pediatric neuroimmune disorders.
  • [MeSH-minor] Age Factors. Child. Humans

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 21183131.001).
  • [ISSN] 1558-0776
  • [Journal-full-title] Seminars in pediatric neurology
  • [ISO-abbreviation] Semin Pediatr Neurol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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77. Campbell LK, Scaduto M, Van Slyke D, Niarhos F, Whitlock JA, Compas BE: Executive function, coping, and behavior in survivors of childhood acute lymphocytic leukemia. J Pediatr Psychol; 2009 Apr;34(3):317-27
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Executive function, coping, and behavior in survivors of childhood acute lymphocytic leukemia.
  • OBJECTIVE: To examine the role of executive function in coping and behavioral outcomes in childhood acute lymphocytic leukemia (ALL) survivors.
  • Directions for future research on executive function deficits and coping skills in survivors of pediatric ALL are suggested.
  • [MeSH-major] Adaptation, Psychological. Cognition. Emotions. Precursor Cell Lymphoblastic Leukemia-Lymphoma / psychology. Stress, Psychological / etiology. Survivors / psychology
  • [MeSH-minor] Adolescent. Case-Control Studies. Child. Female. Humans. Male. Neuropsychological Tests / statistics & numerical data. Young Adult

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  • (PMID = 18667478.001).
  • [ISSN] 1465-735X
  • [Journal-full-title] Journal of pediatric psychology
  • [ISO-abbreviation] J Pediatr Psychol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2722127
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78. Harila MJ, Winqvist S, Lanning M, Bloigu R, Harila-Saari AH: Progressive neurocognitive impairment in young adult survivors of childhood acute lymphoblastic leukemia. Pediatr Blood Cancer; 2009 Aug;53(2):156-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Progressive neurocognitive impairment in young adult survivors of childhood acute lymphoblastic leukemia.
  • BACKGROUND: Despite the extensive literature on neuropsychological sequelae after treatment of childhood acute lymphoblastic leukemia (ALL), the very-long-term neurocognitive outcome of the survivors is poorly studied.
  • We assessed neuropsychological functioning in a population-based cohort of young adult childhood ALL survivors.
  • CONCLUSIONS: Survivors of childhood ALL suffer from long-lasting progressive neuropsychological impairment, especially when treatment includes cranial irradiation.
  • [MeSH-major] Brain Neoplasms / complications. Cognition Disorders / epidemiology. Cognition Disorders / etiology. Cranial Irradiation / adverse effects. Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications
  • [MeSH-minor] Adolescent. Adult. Age of Onset. Antineoplastic Agents / adverse effects. Child. Child, Preschool. Combined Modality Therapy. Disease Progression. Female. Humans. Infant. Infant, Newborn. Male. Neuropsychological Tests. Survivors. Young Adult


79. Kikuchi A, Maeda M, Hanada R, Okimoto Y, Ishimoto K, Kaneko T, Ikuta K, Tsuchida M, Tokyo Children's Cancer Study Group (TCCSG): Moyamoya syndrome following childhood acute lymphoblastic leukemia. Pediatr Blood Cancer; 2007 Mar;48(3):268-72
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  • [Title] Moyamoya syndrome following childhood acute lymphoblastic leukemia.
  • BACKGROUND: Long-term survivors of childhood acute lymphoblastic leukemia (ALL) sometimes suffer from adverse long-term sequelae.
  • We analyzed the incidence, clinical course and prognosis of moyamoya syndrome (MoS) following childhood ALL.
  • RESULTS: Six patients with MoS were identified: four boys and two girls whose ages ranged from 2 years and 1 month (abbreviated as "2y1m") to 14y 1 m at diagnosis of ALL.
  • None of the patients had central nervous system (CNS) leukemia.
  • [MeSH-major] Cranial Irradiation / adverse effects. Moyamoya Disease / etiology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications
  • [MeSH-minor] Adolescent. Anthracyclines / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Asparaginase / administration & dosage. Cerebral Infarction / etiology. Child. Child, Preschool. Combined Modality Therapy. Cyclophosphamide / administration & dosage. Dexamethasone / administration & dosage. Disease Susceptibility. Female. Follow-Up Studies. Humans. Incidence. Japan / epidemiology. Male. Prednisolone / administration & dosage. Quality of Life. Remission Induction. Vincristine / administration & dosage

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16615044.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anthracyclines; 5J49Q6B70F / Vincristine; 7S5I7G3JQL / Dexamethasone; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; EC 3.5.1.1 / Asparaginase
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80. Fangusaro J: Pediatric high-grade gliomas and diffuse intrinsic pontine gliomas. J Child Neurol; 2009 Nov;24(11):1409-17
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  • [Title] Pediatric high-grade gliomas and diffuse intrinsic pontine gliomas.
  • Pediatric high-grade gliomas represent approximately 10% of all pediatric brain tumors.
  • In this review, we present an overview of both pediatric high-grade gliomas and diffuse intrinsic pontine gliomas with a focus on their epidemiology, etiology, presentation, prognostic factors, biology, treatment modalities, outcomes, and future research directions.
  • [MeSH-minor] Child. Humans. Models, Neurological. Neoplasm Staging

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  • (PMID = 19638636.001).
  • [ISSN] 1708-8283
  • [Journal-full-title] Journal of child neurology
  • [ISO-abbreviation] J. Child Neurol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 83
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81. Abuidris DO, Ahmed ME, Elgaili EM, Arora RS: Childhood cancer in Sudan: 1999-2007. Trop Doct; 2008 Oct;38(4):208-10
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  • [Title] Childhood cancer in Sudan: 1999-2007.
  • There is paucity of information on childhood cancer from Sudan with the last studies published more than 20 years ago.
  • This study aims to provide a current picture of childhood cancer in Sudan.
  • Lymphomas (111, 35%), leukaemia (83, 26%) and Wilms' tumour (43, 13%) were the three most common groups of tumours.
  • Thirty percent of all lymphomas were Burkitt's lymphoma; 3.4% of all childhood cancer cases were nasopharyngeal carcinomas.
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Humans. Infant. Infant, Newborn. Male. Sudan / epidemiology. Time Factors

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  • (PMID = 18820183.001).
  • [ISSN] 0049-4755
  • [Journal-full-title] Tropical doctor
  • [ISO-abbreviation] Trop Doct
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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82. Dengel DR, Ness KK, Glasser SP, Williamson EB, Baker KS, Gurney JG: Endothelial function in young adult survivors of childhood acute lymphoblastic leukemia. J Pediatr Hematol Oncol; 2008 Jan;30(1):20-5
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  • [Title] Endothelial function in young adult survivors of childhood acute lymphoblastic leukemia.
  • BACKGROUND: Adult survivors of childhood acute lymphoblastic leukemia (ALL) have an earlier than expected mortality from cardiovascular disease.
  • This study examined endothelial function in 75 young (age 30.2+/-7.1 y) adult survivors of childhood ALL who received chemotherapy without cranial radiation (n=25) or chemotherapy combined with cranial radiation (n=50) compared with a healthy control group of similar sex, age, and weight (n=59).
  • CONCLUSIONS: These data suggest that young adults treated for ALL during childhood are at risk for impaired FMD regardless of whether or not they received cranial irradiation.
  • The extent to which this mechanism relates to early development of cardiovascular disease in long-term childhood ALL survivors remains to be determined.
  • [MeSH-major] Brachial Artery / physiopathology. Endothelium, Vascular / physiopathology. Nitroglycerin / administration & dosage. Precursor Cell Lymphoblastic Leukemia-Lymphoma / physiopathology. Vasodilation / drug effects. Vasodilator Agents / administration & dosage
  • [MeSH-minor] Adult. Child. Child, Preschool. Cranial Irradiation. Female. Follow-Up Studies. Humans. Male. Sex Factors. Survivors

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  • (PMID = 18176175.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / M01-RR00400; United States / NCI NIH HHS / CA / R21-CA106778; United States / NCI NIH HHS / CA / U24-CA55727
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vasodilator Agents; G59M7S0WS3 / Nitroglycerin
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83. Butturini AM, Dorey FJ, Lange BJ, Henry DW, Gaynon PS, Fu C, Franklin J, Siegel SE, Seibel NL, Rogers PC, Sather H, Trigg M, Bleyer WA, Carroll WL: Obesity and outcome in pediatric acute lymphoblastic leukemia. J Clin Oncol; 2007 May 20;25(15):2063-9
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  • [Title] Obesity and outcome in pediatric acute lymphoblastic leukemia.
  • PURPOSE: To evaluate the effect of obesity (defined as a body mass index > 95th percentile for age and sex at diagnosis) on outcome of pediatric acute lymphoblastic leukemia (ALL).
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Obesity / complications. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • [MeSH-minor] Adolescent. Adult. Body Mass Index. Child. Child, Preschool. Cohort Studies. Disease-Free Survival. Female. Humans. Male. Retrospective Studies. Treatment Outcome

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  • (PMID = 17513811.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA13539; United States / NCI NIH HHS / CA / CA98543
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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84. Nakamura M, Shimada K, Ishida E, Higuchi T, Nakase H, Sakaki T, Konishi N: Molecular pathogenesis of pediatric astrocytic tumors. Neuro Oncol; 2007 Apr;9(2):113-23
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  • [Title] Molecular pathogenesis of pediatric astrocytic tumors.
  • Astrocytomas are the most common pediatric brain tumors, accounting for 7%-8% of all childhood cancers.
  • Relatively few studies have been performed on their molecular properties; therefore, classification of pediatric astrocytic tumors into genetic subtypes similar to that of adult tumors remains to be defined.
  • Here, we report an extensive characterization of 44 pediatric astrocytomas--16 diffuse astrocytomas (WHO grade II), 10 anaplastic astrocytomas (WHO grade III), and 18 glioblastomas (WHO grade IV)--in terms of genetic alterations frequently observed in adult astrocytomas.
  • Loss of heterozygosity (LOH) on 1p/19q and 10p/10q was less common in pediatric astrocytic tumors than in those seen in adults, but the frequency of LOH on 22q was comparable, occurring in 44% of diffuse astrocytomas, 40% of anaplastic astrocytomas, and 61% of glioblastomas.
  • Our results suggest some differences in children compared to adults in the genetic pathways leading to the formation of de novo astrocytic tumors.
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Chromosomes, Human, Pair 1. Chromosomes, Human, Pair 10. Chromosomes, Human, Pair 19. Chromosomes, Human, Pair 22. DNA Mutational Analysis. Female. Gene Amplification. Genes, p53. Glioblastoma / genetics. Humans. Loss of Heterozygosity. Male. Mutation. PTEN Phosphohydrolase / genetics. Receptor, Epidermal Growth Factor / genetics. Receptor, Platelet-Derived Growth Factor beta / genetics

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  • (PMID = 17327574.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor beta; EC 3.1.3.67 / PTEN Phosphohydrolase
  • [Other-IDs] NLM/ PMC1871665
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85. Haarman EG, Kaspers GJ, Pieters R, Rottier MM, Veerman AJ: Circumvention of glucocorticoid resistance in childhood leukemia. Leuk Res; 2008 Sep;32(9):1417-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Circumvention of glucocorticoid resistance in childhood leukemia.
  • In this study, we determined if in vitro resistance to prednisolone and dexamethasone could be circumvented by cortivazol or methylprednisolone, or reversed by meta-iodobenzylguanidine in pediatric lymphoblastic and myeloid leukemia.
  • As there were strong correlations between the LC50 values (drug concentration inducing 50% leukemic cell kill, LCK) of the different glucocorticoids and median prednisolone/methylprednisolone, prednisolone/dexamethasone and prednisolone/cortivazol LC50 ratios did not differ between the leukemia subtypes, we conclude that none of the glucocorticoids had preferential anti-leukemic activity.
  • Meta-iodobenzylguanidine however, partially reversed glucocorticoid resistance in 19% of the lymphoblastic leukemia samples.
  • [MeSH-major] Drug Resistance, Neoplasm. Glucocorticoids / therapeutic use. Leukemia, Myeloid, Acute / drug therapy. Methylprednisolone / therapeutic use. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Pregnatrienes / therapeutic use
  • [MeSH-minor] Cell Proliferation. Child. Dexamethasone / therapeutic use. Drug Screening Assays, Antitumor. Humans. Prednisolone / therapeutic use. Tumor Cells, Cultured

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  • (PMID = 18395253.001).
  • [ISSN] 0145-2126
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Glucocorticoids; 0 / Pregnatrienes; 7S5I7G3JQL / Dexamethasone; 9PHQ9Y1OLM / Prednisolone; X4W7ZR7023 / Methylprednisolone; YM183K0H63 / cortivazol
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86. Davidsen ML, Dalhoff K, Schmiegelow K: Pharmacogenetics influence treatment efficacy in childhood acute lymphoblastic leukemia. J Pediatr Hematol Oncol; 2008 Nov;30(11):831-49
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  • [Title] Pharmacogenetics influence treatment efficacy in childhood acute lymphoblastic leukemia.
  • As most childhood acute lymphoblastic leukemia treatment protocols include up to 13 different chemotherapeutic agents, the impact of individual SNPs has been difficult to evaluate.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Neoplasm Proteins / genetics. Polymorphism, Genetic. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics


87. Gupta N, Dhawan A, Beri S, D'souza P: Clinical spectrum of pediatric blepharokeratoconjunctivitis. J AAPOS; 2010 Dec;14(6):527-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical spectrum of pediatric blepharokeratoconjunctivitis.
  • METHODS: In this observational, retrospective case series, we reviewed all medical records of pediatric patients presenting to the ophthalmology clinic at the Kalawati Saran Children's Hospital, New Delhi, India from 2003 to 2006.
  • RESULTS: Of 5,012 pediatric patients, 615 (12%) demonstrated features of BKC.
  • CONCLUSIONS: BKC was the commonest diagnosis at consultation among all pediatric referrals.

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  • [Copyright] Copyright © 2010 American Association for Pediatric Ophthalmology and Strabismus. Published by Mosby, Inc. All rights reserved.
  • (PMID = 21093331.001).
  • [ISSN] 1528-3933
  • [Journal-full-title] Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
  • [ISO-abbreviation] J AAPOS
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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88. O'Connor SM, Boneva RS: Infectious etiologies of childhood leukemia: plausibility and challenges to proof. Environ Health Perspect; 2007 Jan;115(1):146-50
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  • [Title] Infectious etiologies of childhood leukemia: plausibility and challenges to proof.
  • Infections as well as environmental exposures are proposed determinants of childhood acute lymphoblastic leukemia (ALL), particularly common precursor B-cell ALL (cALL).
  • Lines of investigation test hypotheses that cALL is a rarer result of common infection, that it results from uncommon infection, or that it ensues from abnormal immune development; perhaps it requires a preceding prenatal or early childhood insult.
  • Ideally, studies should document that particular infections precede leukemiA and induce malignant transformation.
  • Primarily based on surrogate markers of infectious exposure, indirect evidence from ecologic and epidemiologic studies varies widely, but some suggest that infancy or early childhood infectious exposures might protect against childhood ALL or cALL.
  • Other challenges to proof include the likely time lag between infection and diagnosis, the ubiquity of many infections, the influence of age at infection, and the limitations in laboratory assays; small numbers of cases, inaccurate background leukemia rates, and difficulty tracking mobile populations further affect duster investigations.
  • [MeSH-major] Communicable Diseases / complications. Precursor Cell Lymphoblastic Leukemia-Lymphoma / etiology
  • [MeSH-minor] Child. Humans

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  • (PMID = 17366835.001).
  • [ISSN] 0091-6765
  • [Journal-full-title] Environmental health perspectives
  • [ISO-abbreviation] Environ. Health Perspect.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 86
  • [Other-IDs] NLM/ PMC1817664
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89. Schotte D, Chau JC, Sylvester G, Liu G, Chen C, van der Velden VH, Broekhuis MJ, Peters TC, Pieters R, den Boer ML: Identification of new microRNA genes and aberrant microRNA profiles in childhood acute lymphoblastic leukemia. Leukemia; 2009 Feb;23(2):313-22
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  • [Title] Identification of new microRNA genes and aberrant microRNA profiles in childhood acute lymphoblastic leukemia.
  • To identify miRNAs relevant to pediatric acute lymphoblastic leukemia (ALL), we cloned 105 known and 8 new miRNA genes expressed in patients' leukemia cells.
  • Eight miRNAs were differentially expressed between MLL and non-MLL precursor B-ALL cases (P<0.05).
  • Most remarkably, miR-708 was 250- up to 6500-fold higher expressed in 57 TEL-AML1, BCR-ABL, E2A-PBX1, hyperdiploid and B-other cases than in 20 MLL-rearranged and 15 T-ALL cases (0.0001<P<0.01), whereas the expression of miR-196b was 500-fold higher in MLL-rearranged and 800-fold higher in 5 of 15 T-ALL cases as compared with the expression level in the remaining precursor B-ALL cases (P<0.001).
  • The expression did not correlate with the maturation status of leukemia cells based on immunoglobulin and T-cell receptor rearrangements, immunophenotype or MLL-fusion partner.
  • [MeSH-major] MicroRNAs / genetics. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics. RNA, Neoplasm / genetics
  • [MeSH-minor] Cloning, Molecular. Gene Expression Regulation, Neoplastic. Humans. Infant. Infant, Newborn. Myeloid-Lymphoid Leukemia Protein / genetics


90. Pakakasama S, Sirirat T, Kanchanachumpol S, Udomsubpayakul U, Mahasirimongkol S, Kitpoka P, Thithapandha A, Hongeng S: Genetic polymorphisms and haplotypes of DNA repair genes in childhood acute lymphoblastic leukemia. Pediatr Blood Cancer; 2007 Jan;48(1):16-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genetic polymorphisms and haplotypes of DNA repair genes in childhood acute lymphoblastic leukemia.
  • This study was performed to evaluate the effect of the polymorphisms of DNA repair genes on risk of childhood acute lymphoblastic leukemia (ALL).
  • CONCLUSION: The XRCC1 194Trp allele and haplotype B showed a protective effect against development of childhood ALL.
  • [MeSH-major] Alleles. DNA Repair. DNA-Binding Proteins / genetics. Genetic Predisposition to Disease. Polymorphism, Genetic. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Gene Frequency / genetics. Haplotypes. Humans. Infant. Male. Mutation, Missense. Retrospective Studies. Risk Factors

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16435384.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / X-ray repair cross complementing protein 1
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91. Cost NG, Lee J, Snodgrass WT, Harrison CB, Wilcox DT, Baker LA: Hernia after pediatric urological laparoscopy. J Urol; 2010 Mar;183(3):1163-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hernia after pediatric urological laparoscopy.
  • There are no known published reports concerning hernia incidence or related factors after pediatric urological laparoscopic interventions.
  • We present our experience with port site incisional hernias following pediatric urological laparoscopy.
  • MATERIALS AND METHODS: We reviewed all pediatric urological laparoscopic procedures performed at Children's Medical Center Dallas from 2000 to 2008.
  • CONCLUSIONS: The incidence of port site hernia after pediatric urological laparoscopy was 3.2%, similar to the reported incidence in adults.
  • While development of hernia after pediatric urological laparoscopy is rare, it is more likely to occur in infants.
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Humans. Infant. Retrospective Studies

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  • [Copyright] 2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.
  • [CommentIn] J Urol. 2010 Mar;183(3):1167 [20096875.001]
  • (PMID = 20096869.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. Babay HA, Twum-Danso K, Kambal AM, Al-Otaibi FE: Bloodstream infections in pediatric patients. Saudi Med J; 2005 Oct;26(10):1555-61

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bloodstream infections in pediatric patients.
  • OBJECTIVE: Blood stream infection (BSI) is the leading cause of morbidity and mortality in pediatric patients.
  • This study aims to describe the clinical, microbiological characteristics and outcome of BSI in pediatric patients.
  • METHODS: We collected the clinical data from all pediatric patients with positive blood cultures.
  • RESULTS: Two hundred and twenty pediatric patients had BSI, of whom 147 (67%) were males and 71 (32.2%) were from intensive care units (ICUs).
  • Fever was the most common presentation of pediatric patients (26%) with positive blood culture with no apparent focus of infection.
  • Bone and joint infections, cardiac, renal, gastrointestinal diseases, malignancy and surgical cases were other associated clinical diagnoses of BSI in pediatric patients.
  • CONCLUSION: Bloodstream infection is an important cause of morbidity and mortality in pediatric patients.
  • [MeSH-minor] Adolescent. Age Distribution. Child. Child, Preschool. Cohort Studies. Female. Humans. Incidence. Infant. Intensive Care Units, Neonatal. Intensive Care Units, Pediatric. Male. Risk Assessment. Saudi Arabia / epidemiology. Severity of Illness Index. Sex Distribution. Survival Analysis

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  • (PMID = 16228055.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
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93. Ievers-Landis CE, Redline S: Pediatric sleep apnea: implications of the epidemic of childhood overweight. Am J Respir Crit Care Med; 2007 Mar 1;175(5):436-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pediatric sleep apnea: implications of the epidemic of childhood overweight.
  • Over the last 30 years, the prevalence of overweight across all pediatric age groups and ethnicities has increased substantially, with the current prevalence of overweight among adolescents estimated to be approximately 30%.
  • The rising incidence of pediatric overweight likely will impact the prevalence, presentation, and treatment of childhood OSAS.
  • An increased prevalence of overweight also may impact the response to adenotonsillectomy as a primary treatment for childhood OSAS.
  • The high and anticipated increased prevalence of pediatric OSAS mandates assessment of optimal approaches for preventing and treating both OSAS and overweight across the pediatric age range.
  • In this Pulmonary Perspective, the interrelationships between pediatric OSAS and overweight are reviewed, and the implications of the overweight epidemic on childhood OSAS are discussed.

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  • (PMID = 17158283.001).
  • [ISSN] 1073-449X
  • [Journal-full-title] American journal of respiratory and critical care medicine
  • [ISO-abbreviation] Am. J. Respir. Crit. Care Med.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / 1 U54CA116867; United States / NHLBI NIH HHS / HL / HL 070916; United States / NCI NIH HHS / CA / U54CA11687
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Number-of-references] 84
  • [Other-IDs] NLM/ PMC2176093
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94. Ford AM, Martínez-Ramírez A: Therapeutic opportunities and targets in childhood leukemia. Clin Transl Oncol; 2006 Aug;8(8):560-5
MedlinePlus Health Information. consumer health - Leukemia.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Therapeutic opportunities and targets in childhood leukemia.
  • Childhood leukemia is a common pediatric cancer in the developed world, the disease is biologically diverse and there is much discussion as to its causal mechanisms.
  • Acute lymphoblastic leukemia (ALL) is the most common subtype and infants with ALL have a greatly increased risk of treatment failure.
  • [MeSH-major] Leukemia / genetics. Leukemia / therapy
  • [MeSH-minor] Adolescent. Antibodies, Monoclonal / therapeutic use. Child. Child, Preschool. Humans. Immunization, Passive. Immunotherapy, Active. Infant. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics. Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy. Stem Cells

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  • (PMID = 16952844.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal
  • [Number-of-references] 41
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95. Bachmann PS, Piazza RG, Janes ME, Wong NC, Davies C, Mogavero A, Bhadri VA, Szymanska B, Geninson G, Magistroni V, Cazzaniga G, Biondi A, Miranda-Saavedra D, Göttgens B, Saffery R, Craig JM, Marshall GM, Gambacorti-Passerini C, Pimanda JE, Lock RB: Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition. Blood; 2010 Oct 21;116(16):3013-22
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition.
  • Glucocorticoids play a critical role in the therapy of lymphoid malignancies, including pediatric acute lymphoblastic leukemia (ALL), although the mechanisms underlying cellular resistance remain unclear.
  • We report glucocorticoid resistance attributable to epigenetic silencing of the BIM gene in pediatric ALL biopsies and xenografts established in immune-deficient mice from direct patient explants as well as a therapeutic approach to reverse resistance in vivo.
  • These findings provide a novel therapeutic strategy to reverse glucocorticoid resistance and improve outcome for high-risk pediatric ALL.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Apoptosis Regulatory Proteins / genetics. Drug Resistance, Neoplasm. Gene Silencing. Glucocorticoids / therapeutic use. Histone Deacetylase Inhibitors / therapeutic use. Membrane Proteins / genetics. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics. Proto-Oncogene Proteins / genetics
  • [MeSH-minor] Animals. Antineoplastic Agents, Hormonal / pharmacology. Antineoplastic Agents, Hormonal / therapeutic use. Bcl-2-Like Protein 11. Child. Dexamethasone / pharmacology. Dexamethasone / therapeutic use. Genetic Loci. Histone Deacetylases / metabolism. Humans. Hydroxamic Acids / pharmacology. Hydroxamic Acids / therapeutic use. Mice. Mice, SCID

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  • (PMID = 20647567.001).
  • [ISSN] 1528-0020
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / MRC/ G0800784; United Kingdom / National Centre for the Replacement, Refinement and Reduction of Animals in Research / / NC3RS/ G0900729/1
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Hormonal; 0 / Apoptosis Regulatory Proteins; 0 / BCL2L11 protein, human; 0 / Bcl-2-Like Protein 11; 0 / Bcl2l11 protein, mouse; 0 / Glucocorticoids; 0 / Histone Deacetylase Inhibitors; 0 / Hydroxamic Acids; 0 / Membrane Proteins; 0 / Proto-Oncogene Proteins; 58IFB293JI / vorinostat; 7S5I7G3JQL / Dexamethasone; EC 3.5.1.98 / Histone Deacetylases
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96. Harper JD, Shah SK, Baldwin DD, Moorhead JD: Laparoscopic nephrectomy for pediatric giant hydronephrosis. Urology; 2007 Jul;70(1):153-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic nephrectomy for pediatric giant hydronephrosis.
  • OBJECTIVES: To describe our experience with pediatric laparoscopic nephrectomy (LN) and laparoscopic nephroureterectomy (LNU) for giant hydronephrosis.
  • METHODS: A retrospective review was conducted of all pediatric patients undergoing a transperitoneal LN or LNU.
  • CONCLUSIONS: Although pediatric LN and LNU for giant hydronephrosis present unique challenges owing to the large renal volume in a small abdominal cavity, these procedures can be safely performed with careful attention to the altered anatomic relationships.
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Humans. Retrospective Studies

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  • (PMID = 17656227.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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97. Pession A, Masetti R, Kleinschmidt K, Martoni A: Use of clofarabine for acute childhood leukemia. Biologics; 2010;4:111-8
SciCrunch. DrugBank: Data: Chemical .

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  • [Title] Use of clofarabine for acute childhood leukemia.
  • A second-generation of purine nucleoside analogs, starting with clofarabine, has been developed in the course of the search for new therapeutic agents for acute childhood leukemia, especially for refractory or relapsed disease.
  • Clofarabine is a hybrid of fludarabine and cladribine, and has shown to have antileukemic activity in acute lymphoblastic leukemia as well as in myeloid disorders.
  • As the only new antileukemic chemotherapeutic agent to enter clinical use in the last 10 years, clofarabine was approved as an orphan drug with the primary indication of use in pediatric patients.

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  • (PMID = 20631817.001).
  • [ISSN] 1177-5491
  • [Journal-full-title] Biologics : targets & therapy
  • [ISO-abbreviation] Biologics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Other-IDs] NLM/ PMC2898101
  • [Keywords] NOTNLM ; clofarabine / pediatric acute lymphoblastic leukemia / pediatric acute myeloid leukemia
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98. Von Behren J, Reynolds P, Gunier RB, Rull RP, Hertz A, Urayama KY, Kronish D, Buffler PA: Residential traffic density and childhood leukemia risk. Cancer Epidemiol Biomarkers Prev; 2008 Sep;17(9):2298-301
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Residential traffic density and childhood leukemia risk.
  • BACKGROUND: Exposures to carcinogenic compounds from vehicle exhaust may increase childhood leukemia risk, and the timing of this exposure may be important.
  • METHODS: We examined the association between traffic density and childhood leukemia risk for three time periods: birth, time of diagnosis, and lifetime average, based on complete residential history in a case-control study.
  • RESULTS: We included 310 cases of acute lymphocytic leukemias (ALL) and 396 controls in our analysis.
  • CONCLUSIONS: Living in areas of high traffic density during any of the exposure time periods was not associated with increased risk of childhood ALL in this study.

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  • (PMID = 18768496.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA092674-05; United States / NCI NIH HHS / CA / R01-CA92674; United States / NIEHS NIH HHS / ES / R01-ES09137; United States / NIEHS NIH HHS / ES / R01 ES009137; United States / NCI NIH HHS / CA / R01 CA092674-05; United States / NCI NIH HHS / CA / R01 CA092674
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vehicle Emissions
  • [Other-IDs] NLM/ NIHMS93299; NLM/ PMC2706505
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99. Graubner UB, Porzig S, Jorch N, Kolb R, Wessalowski R, Escherich G, Janka GE: Impact of reduction of therapy on infectious complications in childhood acute lymphoblastic leukemia. Pediatr Blood Cancer; 2008 Feb;50(2):259-63
Genetic Alliance. consumer health - Acute Lymphoblastic Leukemia, Childhood.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Impact of reduction of therapy on infectious complications in childhood acute lymphoblastic leukemia.
  • BACKGROUND: Infections are a major cause of morbidity and mortality in childhood acute lymphoblastic leukemia (ALL) and only limited information is available on infectious complications.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Infection / etiology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Precursor Cell Lymphoblastic Leukemia-Lymphoma / microbiology
  • [MeSH-minor] Child. Child, Preschool. Female. Humans. Infant. Male. Risk Factors. Treatment Outcome

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17635005.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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100. Karremann M, Rausche U, Fleischhack G, Nathrath M, Pietsch T, Kramm CM, Wolff JE: Clinical and epidemiological characteristics of pediatric gliosarcomas. J Neurooncol; 2010 Apr;97(2):257-65
MedlinePlus Health Information. consumer health - Childhood Brain Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical and epidemiological characteristics of pediatric gliosarcomas.
  • We studied the clinical relevance of this histological glioblastoma subentity within the pediatric population.
  • We obtained patient data from the German HIT-GBM database, which contains clinical data for more than 600 pediatric patients with centrally reviewed high-grade gliomas.
  • In the whole series of 23 pediatric GS patients, including previously reported cases, the male-to-female-ratio was 1.2:1.
  • GS was found in all pediatric age groups with a median age of 11 years, but there was an unexpectedly high accumulation in infants (6 of 23 <3 years of age, 26%).
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Humans. Infant. Infant, Newborn. Kaplan-Meier Estimate. Male. Young Adult

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  • (PMID = 19806321.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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