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1. Nagatoshi Y, Matsuzaki A, Suminoe A, Inada H, Ueda K, Kawakami K, Yanai F, Nakayama H, Moritake H, Itonaga N, Hotta N, Fujita K, Hidaka Y, Yamanaka T, Kawano Y, Okamura J: Randomized trial to compare LSA2L2-type maintenance therapy to daily 6-mercaptopurine and weekly methotrexate with vincristine and dexamethasone pulse for children with acute lymphoblastic leukemia. Pediatr Blood Cancer; 2010 Aug;55(2):239-47
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  • [Title] Randomized trial to compare LSA2L2-type maintenance therapy to daily 6-mercaptopurine and weekly methotrexate with vincristine and dexamethasone pulse for children with acute lymphoblastic leukemia.
  • BACKGROUND: A total of 201 pediatric cases of acute lymphoblastic leukemia were treated with the ALL-96 protocol by the Kyushu-Yamaguchi Children's Cancer Study Group.
  • All of the patients were classified into standard-risk (SR) or high-risk (HR) groups and were randomly assigned to receive maintenance therapy with either LSA2L2-type or 6-mercaptopurine (6-MP)/methotrexate (MTX) with vincristine (VCR) and dexamethasone (DEX) pulse in both risk groups.
  • [MeSH-major] 6-Mercaptopurine / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy

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  • [Copyright] (c) 2010 Wiley-Liss, Inc.
  • (PMID = 20582970.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 7S5I7G3JQL / Dexamethasone; 8N3DW7272P / Cyclophosphamide; E7WED276I5 / 6-Mercaptopurine; VB0R961HZT / Prednisone; YL5FZ2Y5U1 / Methotrexate; ZS7284E0ZP / Daunorubicin; LSA2-L2 protocol
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2. Sekiguchi Y, Mori S, Aoki K, Higuchi T, Nishida J: [A case of rheumatoid arthritis with acute lymphoblastic leukemia]. Nihon Rinsho Meneki Gakkai Kaishi; 2007 Dec;30(6):461-6
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  • [Title] [A case of rheumatoid arthritis with acute lymphoblastic leukemia].
  • However, since the fever, pancytopenia and liver dysfunction persisted, bone marrow examination was performed and the patient was diagnosed with acute lymphoblastic leukemia (pre B cell type, L2).
  • [MeSH-major] Arthritis, Rheumatoid / complications. Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications


3. Mori A, Toyoshima N, Saito M, Oka T, Irie T, Morioka M: [Hypercalcemia and multiple osteolytic lesions associated with proinflammatory cytokines in a patient with acute lymphoblastic leukemia]. Rinsho Ketsueki; 2007 Jul;48(7):559-64
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  • [Title] [Hypercalcemia and multiple osteolytic lesions associated with proinflammatory cytokines in a patient with acute lymphoblastic leukemia].
  • Bone marrow aspiration revealed increased lymphoblasts (48%), and the patient was diagnosed as having acute lymphoblastic leukemia (ALL, L2).
  • However, he died of acute pneumonia and gastrointestinal bleeding.
  • [MeSH-major] Cytokines / physiology. Hypercalcemia / etiology. Osteolysis. Precursor Cell Lymphoblastic Leukemia-Lymphoma / physiopathology

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  • (PMID = 17695305.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Cytokines; 0 / Interleukin-6; 0 / Parathyroid Hormone-Related Protein; 0 / Tumor Necrosis Factor-alpha
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4. Badowska W: [Analysis of therapy results and prognostic factors in children with acute lymphoblastic leukaemia in Warmia and Mazury region: 17-years experience]. Med Wieku Rozwoj; 2008 Oct-Dec;12(4 Pt 2):1001-7
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  • [Title] [Analysis of therapy results and prognostic factors in children with acute lymphoblastic leukaemia in Warmia and Mazury region: 17-years experience].
  • In the Warmia and Mazury region inhabited by 1.4 mln people, 6-16 new cases od childhood acute leukaemia are reported every year.
  • AIM: Analysis of treatment outcome and identification of prognostic factors in children treated for acute lymphoblastic leukaemia (ALL).
  • Prognostic factors for pEFS by univariate analysis were: male gender (p=0.003), age under 2 year (p=0.004), spleen enlargement (p=0.043), Hgb>10g/dl (p=0.025), WBC>100 G/L (p=0.007), FAB L2 (p<0.001), loss of weight p=0.022 and defects of eyesight (p=0.006) before the diagnosis of ALL, and HBV infection during the therapy (p=0.019).
  • Independent risk factors by multivariate analysis were: male gender (p=0.005), age under 2 year (p=0.052), the spleen enlargement (p=0.028), WBC>100 G/L (p=0.007), FAB L2 (p=0.007), eyesight defects (p=0.009) before the diagnosis of ALL, and infection of HBV during the therapy (p=0.027).
  • CONCLUSIONS: Large progress has been made in the treatment of acute lymphoblastic leukaemia of childhood and adolescence over the analyzed period of 17 years.
  • Treatment results for children with acute lymphoblastic leukaemia in Olsztyn Province are similar to the results in the Polish Paediatric Leukaemia/Lymphoma Study Group.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy

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  • (PMID = 19531816.001).
  • [Journal-full-title] Medycyna wieku rozwojowego
  • [ISO-abbreviation] Med Wieku Rozwoj
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 04079A1RDZ / Cytarabine; 5J49Q6B70F / Vincristine; 8N3DW7272P / Cyclophosphamide; EC 3.5.1.1 / Asparaginase; FTK8U1GZNX / Thioguanine; VB0R961HZT / Prednisone; YL5FZ2Y5U1 / Methotrexate; ZS7284E0ZP / Daunorubicin; New York protocol; PVDA protocol
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5. Specchia G, Albano F, Anelli L, Zagaria A, Liso A, Pannunzio A, Archidiacono N, Liso V, Rocchi M: Molecular cytogenetic study of instability at 1q21 approximately q32 in adult acute lymphoblastic leukemia. Cancer Genet Cytogenet; 2005 Jan 1;156(1):54-8
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  • [Title] Molecular cytogenetic study of instability at 1q21 approximately q32 in adult acute lymphoblastic leukemia.
  • In the present paper, we report a molecular cytogenetic study of 1q abnormalities associated with t(8;14)(q24;q32) in an adult common B acute lymphoblastic leukemia case with FAB-L2 morphology.
  • The use of appropriate molecular cytogenetic probes allowed us to detect 13 different subclones showing heterogeneous chromosome 1 abnormalities.
  • [MeSH-major] Chromosome Aberrations. Chromosomes, Human, Pair 1. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics

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  • (PMID = 15588856.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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6. Qin DD, Qi GF, Yang ZY, Wu JC, Liu YC: Fluorescence and biological evaluation of the La(III) and Eu(III) complexes with 7-methoxychromone-3-carbaldehyde benzoyl hydrazone Schiff base. J Fluoresc; 2009 May;19(3):409-18
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  • The crystal structure of [LaL(2)(NO(3))(3)].H(2)O was characterized by X-ray crystallography.

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  • (PMID = 18937060.001).
  • [ISSN] 1573-4994
  • [Journal-full-title] Journal of fluorescence
  • [ISO-abbreviation] J Fluoresc
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / 7-methoxychromone-3-carbaldehyde-benzoylhydrazone; 0 / Antineoplastic Agents; 0 / Chromones; 0 / Free Radical Scavengers; 0 / Hydrazones; 0 / Intercalating Agents; 0 / Ligands; 0 / Organometallic Compounds; 0 / Solvents; 11062-77-4 / Superoxides; 3352-57-6 / Hydroxyl Radical; 444W947O8O / Europium; 6I3K30563S / Lanthanum; 9007-49-2 / DNA
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7. Pelz AF, Müller G, Wieacker P: Jumping translocation of 1q in a BCR/ABL-positive acute lymphoblastic leukemia. Cancer Genet Cytogenet; 2005 Mar;157(2):157-9
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  • [Title] Jumping translocation of 1q in a BCR/ABL-positive acute lymphoblastic leukemia.
  • Jumping translocations (JT) are rare chromosomal abnormalities in which an identical copy of a chromosomal region (donor) is translocated to a different chromosome (acceptor).
  • Chromosome 1 is often involved as donor chromosome.
  • JTs of the long arm of chromosome 1 (1q) or parts of it are associated with a poor outcome.
  • We report on a 72-year-old male patient with a BCR/ABL1 rearrangement positive acute lymphoblastic leukemia (common ALL, or c-ALL; FAB L2 morphology) and with additional structural and numeric aberrations.
  • To the best of our knowledge, neither JT between 1q and chromosome 3 nor JT between 1q and chromosome 22 have been described in c-ALL.
  • [MeSH-major] Chromosomes, Human, Pair 1. Fusion Proteins, bcr-abl / metabolism. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics. Translocation, Genetic

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  • (PMID = 15721638.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.2 / Fusion Proteins, bcr-abl
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8. Hardianti MS, Tatsumi E, Syampurnawati M, Furuta K, Suzuki A, Saigo K, Kawano S, Takenokuchi M, Kumagai S, Matsuo Y, Koizumi T, Takeuchi M: Presence of somatic hypermutation and activation-induced cytidine deaminase in acute lymphoblastic leukemia L2 with t(14;18)(q32;q21). Eur J Haematol; 2005 Jan;74(1):11-9
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  • [Title] Presence of somatic hypermutation and activation-induced cytidine deaminase in acute lymphoblastic leukemia L2 with t(14;18)(q32;q21).
  • AIM: Acute lymphoblastic leukemia (ALL) with L2 (FAB) morphology has rarely been reported to show t(14;18)(q32;q21).
  • We aimed to delineate the stage at which this type of ALL is derived in B-lineage differentiation.
  • The results here give some insight into the relationship between disease type (ALL or lymphoma) and derivation stage, the overlapping of the early stage phenotype and the mature genomic characteristics, and the probable relationship between the mechanism of the occurrence of t(14;18)(q32;q21) and the machinery causing SHM.
  • [MeSH-major] Cytosine Deaminase / genetics. Precursor Cell Lymphoblastic Leukemia-Lymphoma / enzymology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics. Somatic Hypermutation, Immunoglobulin

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  • (PMID = 15613101.001).
  • [ISSN] 0902-4441
  • [Journal-full-title] European journal of haematology
  • [ISO-abbreviation] Eur. J. Haematol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / DNA-Binding Proteins; 0 / Immunoglobulin Heavy Chains; 0 / Immunoglobulin Variable Region; 0 / Nuclear Proteins; 0 / RAG2 protein, human; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / V(D)J recombination activating protein 2; EC 2.7.7.31 / DNA Nucleotidylexotransferase; EC 3.5.4.- / AICDA (activation-induced cytidine deaminase); EC 3.5.4.1 / Cytosine Deaminase; EC 3.5.4.5 / Cytidine Deaminase
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9. Khan AU, Sheikh MU, Intekhab K: Effect of hypoproteinemia on treatment outcome in children with acute lymphoblastic leukemia. J Ayub Med Coll Abbottabad; 2006 Apr-Jun;18(2):53-6
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  • [Title] Effect of hypoproteinemia on treatment outcome in children with acute lymphoblastic leukemia.
  • METHODS: A prospective study was carried out to assess the effects of hypoproteinemia malnutrition on the treatment outcome of children with acute lymphoblastic leukemia.
  • One hundred and sixty three patients with Acute Lymphoblastic Leukemia (ALL) below the age of 14 years with L1 and L2 FAB morphology were included in this study.
  • CONCLUSION: Hypoproteinemia affects treatment outcome in children with acute Lymphoblastic
  • [MeSH-major] Hypoproteinemia / complications. Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy

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  • (PMID = 16977815.001).
  • [ISSN] 1025-9589
  • [Journal-full-title] Journal of Ayub Medical College, Abbottabad : JAMC
  • [ISO-abbreviation] J Ayub Med Coll Abbottabad
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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10. Toubai T, Tanaka J, Ota S, Fukuhara T, Hashino S, Kondo T, Kasai M, Kakinoki Y, Masauzi N, Morioka M, Kawamura T, Iwasaki H, Asaka M, Imamura M: Minimal residual disease (MRD) monitoring using rearrangement of T-cell receptor and immunoglobulin H gene in the treatment of adult acute lymphoblastic leukemia patients. Am J Hematol; 2005 Nov;80(3):181-7
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  • [Title] Minimal residual disease (MRD) monitoring using rearrangement of T-cell receptor and immunoglobulin H gene in the treatment of adult acute lymphoblastic leukemia patients.
  • All patients had L2 type ALL.
  • Our data provide evidence that molecular MRD status of BM is a strong predictor of outcome in adult ALL.
  • [MeSH-major] Gene Rearrangement. Gene Rearrangement, T-Lymphocyte. Immunoglobulin Heavy Chains / genetics. Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
  • [MeSH-minor] Adult. Aged. Antineoplastic Agents / therapeutic use. Clone Cells. Female. Follow-Up Studies. Gene Rearrangement, delta-Chain T-Cell Antigen Receptor. Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor. Humans. Male. Middle Aged. Molecular Diagnostic Techniques. Neoplasm, Residual / diagnosis. Remission Induction. Survival Analysis

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  • (PMID = 16247752.001).
  • [ISSN] 0361-8609
  • [Journal-full-title] American journal of hematology
  • [ISO-abbreviation] Am. J. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Immunoglobulin Heavy Chains
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11. Jeon IS, Yi DY: Acute lymphoblastic leukemia secondary to chemoradiotherapy for perivascular epithelioid cell tumor of uterus. Pediatr Hematol Oncol; 2009 Mar;26(2):85-8
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  • [Title] Acute lymphoblastic leukemia secondary to chemoradiotherapy for perivascular epithelioid cell tumor of uterus.
  • Acute lymphoblastic leukemia (ALL), a primary hematologic malignancy that is especially common in childhood, occurs relatively rarely as a secondary malignant neoplasm.
  • ALL, FAB L2, and immunophenotypically pro-B developed 16 months after the final chemotherapy treatment.
  • [MeSH-major] Neoplasms, Second Primary / etiology. Perivascular Epithelioid Cell Neoplasms / complications. Precursor Cell Lymphoblastic Leukemia-Lymphoma / etiology. Uterine Neoplasms / complications
  • [MeSH-minor] Anthracyclines / adverse effects. Child. Cytogenetic Analysis. Female. Humans. Precursor Cells, B-Lymphoid / pathology. Topoisomerase II Inhibitors. Translocation, Genetic

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  • (PMID = 19322738.001).
  • [ISSN] 1521-0669
  • [Journal-full-title] Pediatric hematology and oncology
  • [ISO-abbreviation] Pediatr Hematol Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anthracyclines; 0 / Topoisomerase II Inhibitors
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12. Kim J, Park TS, Lyu CJ, Song J, Lee KA, Kim SJ, Lee HJ, Choi JR: BCR/ABL rearrangement with b3a3 fusion transcript in a case of childhood acute lymphoblastic leukemia. Cancer Genet Cytogenet; 2009 Mar;189(2):132-7
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  • [Title] BCR/ABL rearrangement with b3a3 fusion transcript in a case of childhood acute lymphoblastic leukemia.
  • The role of BCR/ABL isoforms and their relationship to leukemia phenotype have been of major concern.
  • Atypical BCR/ABL mRNA transcripts lacking exon a2 have been reported in 12 cases of acute lymphoblastic leukemia (ALL) to date; among them, a b3a3 type transcript has been reported only once in the childhood ALL.
  • Reported here is the case of a patient with Philadelphia-positive (Ph(+)) ALL expressing a b3a3 type transcript, a rare type of BCR/ABL mRNA lacking ABL exon a2 sequences.
  • Bone marrow showed a hypercellular marrow with leukemic blasts positive for CD10, CD19, CD79a, and cytoplasmic mu, which is consistent with pre-B ALL.
  • The G-banding and fluorescence in situ hybridization analyses indicated Ph(+).
  • After the patient was diagnosed with ALL-L2, induction chemotherapy was performed and imatinib mesylate was thereafter given as the maintenance therapy.
  • [MeSH-major] Fusion Proteins, bcr-abl / genetics. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics


13. Monette MY, Yada T, Matey V, McCormick SD: Physiological, molecular, and cellular mechanisms of impaired seawater tolerance following exposure of Atlantic salmon, Salmo salar, smolts to acid and aluminum. Aquat Toxicol; 2010 Aug 1;99(1):17-32
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  • We examined the physiological, molecular, and cellular mechanisms of impaired ion regulation in Atlantic salmon, Salmo salar, smolts following acute acid and aluminum (Al) exposure.
  • Smolts were exposed to: control (pH 6.5, 3.4 micrpg l(-1) Al), acid and low Al (LAl: pH 5.4, 11 microg l(-1) Al), acid and moderate Al (MAl: pH 5.3, 42 microg l(-1) Al), and acid and high Al (HAl: pH 5.4, 56 microg l(-1) Al) for two and six days.
  • Exposure to acid/MAl for six days also led to a decrease in gill mRNA expression of the apical Cl(-) channel (cystic fibrosis transmembrane conductance regulator I), increased apoptosis upon seawater exposure, an increase in the surface expression of mitochondria-rich cells (MRCs) within the filament epithelium of the gill, but reduced abundance of gill NKA-positive MRCs.
  • However, MRCs in the gills of smolts exposed to acid/LAl exhibited morphological alterations including decreased size, staining intensity, and shape factor.
  • We demonstrate that the seawater tolerance of Atlantic salmon smolts is extremely sensitive to acute exposure to acid and low levels of Al, and that the mechanisms underlying this depend on the time-course and severity of Al exposure.

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  • [Copyright] Copyright 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20483493.001).
  • [ISSN] 1879-1514
  • [Journal-full-title] Aquatic toxicology (Amsterdam, Netherlands)
  • [ISO-abbreviation] Aquat. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Acid Rain; 0 / Acids; 0 / Water Pollutants, Chemical; 126880-72-6 / Cystic Fibrosis Transmembrane Conductance Regulator; CPD4NFA903 / Aluminum; EC 3.4.22.- / Caspase 3; EC 3.6.3.9 / Sodium-Potassium-Exchanging ATPase
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14. Velasco-Castrejón O, Rivas-Sánchez B, Gutiérrez E, Chávez L, Duarte P, Chavarria S, Rivera-Reyes HH: [Leptospira, does it simulate or cause leukemia?]. Rev Cubana Med Trop; 2005 Jan-Apr;57(1):17-24
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  • [Title] [Leptospira, does it simulate or cause leukemia?].
  • [Transliterated title] Leptospira simulador o causante de leucemia?
  • They were diagnosed myeloblastic leukemia M3 and acute lymphoblastic leukemia L2 by bone marrow aspiration and they were treated as such at the hematology department of a general hospital.
  • It was reviewed the possibility that leptospira could cause leukemoid syndromes and/or leukemia.
  • [MeSH-major] Leptospirosis / complications. Leukemia, Myeloid, Acute / diagnosis. Leukemia, Myeloid, Acute / etiology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis. Precursor Cell Lymphoblastic Leukemia-Lymphoma / etiology

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  • (PMID = 17966470.001).
  • [ISSN] 0375-0760
  • [Journal-full-title] Revista cubana de medicina tropical
  • [ISO-abbreviation] Rev Cubana Med Trop
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Cuba
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15. Zuo YX, Zhang LP, Lu AD, Wang B, Liu GL: [Clinical characteristics of children with B cell type acute lymphoblastic leukemia carrying different fusion gene]. Zhongguo Dang Dai Er Ke Za Zhi; 2010 Mar;12(3):172-6
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  • [Title] [Clinical characteristics of children with B cell type acute lymphoblastic leukemia carrying different fusion gene].
  • OBJECTIVE: To investigate whether there were differences in the clinical characteristics, cytogenetic characteristics, immunophenotype and prognosis in children with B cell type acute lymphoblastic leukemia (B-ALL) carrying different fusion genes.
  • Eighteen children were positive for TEL/AML1, 14 for E2A/PBX1, 11 for BCR/ABL,and 2 cases for MLL/AF4, and 35 cases were negative for all of the 4 fusion genes.
  • FAB-L2 morphology was commonly observed, but t(12;21) was often absence in these children.
  • Thirteen children showed FAB-L1 morphology.
  • In the 11 children with BCR/ABL+B-ALL, 10 children showed common B type immunophenotype.
  • FAB-L1 and FAB-L2 morphology was found in 4 children respectively.
  • Two children with MLL/AF4 positive B-ALL had high tumor load.
  • Their morphologic diagnosis was FAB-L1.
  • [MeSH-major] Gene Fusion. Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Core Binding Factor Alpha 2 Subunit / genetics. Female. Homeodomain Proteins / genetics. Humans. Immunophenotyping. Infant. Male. Myeloid-Lymphoid Leukemia Protein / genetics. Oncogene Proteins, Fusion / genetics

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  • (PMID = 20350423.001).
  • [ISSN] 1008-8830
  • [Journal-full-title] Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
  • [ISO-abbreviation] Zhongguo Dang Dai Er Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Core Binding Factor Alpha 2 Subunit; 0 / Homeodomain Proteins; 0 / MLL-AF4 fusion protein, human; 0 / Oncogene Proteins, Fusion; 0 / TEL-AML1 fusion protein; 146150-85-8 / E2A-Pbx1 fusion protein; 149025-06-9 / Myeloid-Lymphoid Leukemia Protein
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16. Jancik V, Roesky HW: Unusual Anions [LAl(SH)(S)]- and [LAl(S)2]2- stabilized by weakly coordinating imidazolium cations. synthesis of LAl(SSiMe2)2O (L = HC[C(Me)N(Ar)]2, Ar = 2,6-iPr2C6H3). Inorg Chem; 2005 Aug 8;44(16):5556-8
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  • [Title] Unusual Anions [LAl(SH)(S)]- and [LAl(S)2]2- stabilized by weakly coordinating imidazolium cations. synthesis of LAl(SSiMe2)2O (L = HC[C(Me)N(Ar)]2, Ar = 2,6-iPr2C6H3).
  • Monomeric mono- and bis-imidazolium salts [C(t)H(+)][LAl(SH)(S)](-) ([C(t)H(+)] = N,N'-bis-tert-butylimidazolium), [C(m)H(+)][LAl(SH)(S)](-), and [C(m)H(+)](2)[LAl(S)(2)](2-) ([C(m)H(+)] = N,N'-bismesitylimidazolium), containing unusual anions [LAl(SH)(S)](-) and [LAl(S)(2)](2-), have been synthesized in nearly quantitative yields.
  • Furthermore, [C(m)H(+)](2)[LAl(S)(2)](2-) has been successfully used for the preparation of LAl(SSiMe(2))(2)O containing the [O(Me(2)SiS)(2)](2-) ligand.

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  • (PMID = 16060603.001).
  • [ISSN] 0020-1669
  • [Journal-full-title] Inorganic chemistry
  • [ISO-abbreviation] Inorg Chem
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Hafiz MG, Islam A, Siddique R: Back pain and vertebral compression: an unusual presentation of childhood acute lymphoblastic leukemia. Mymensingh Med J; 2010 Jan;19(1):130-6
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  • [Title] Back pain and vertebral compression: an unusual presentation of childhood acute lymphoblastic leukemia.
  • Two weeks before admission, the hematological findings were suggestive of leukemia of lymphoblastic type.
  • Bone marrow morphology study and the cytochemistry of the aspirated marrow were consistent with acute lymphoblastic leukemia (ALL-L2).


18. Mei L, Chen C, Xue G, He Q, Li T, Xue F, Yang Q, Dong Q: Neural predictors of auditory word learning. Neuroreport; 2008 Jan 22;19(2):215-9
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  • Twenty-four native Chinese speakers were trained to learn a logographic artificial language (LAL) for 2 weeks and their behavioral performance was recorded.
  • [MeSH-minor] Acoustic Stimulation. Adolescent. Adult. Brain Mapping. Female. Frontal Lobe / anatomy & histology. Frontal Lobe / physiology. Functional Laterality / physiology. Humans. Language Tests. Magnetic Resonance Imaging. Male. Neural Pathways / anatomy & histology. Neural Pathways / physiology. Predictive Value of Tests. Reaction Time / physiology. Temporal Lobe / anatomy & histology. Temporal Lobe / physiology

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  • (PMID = 18185111.001).
  • [ISSN] 0959-4965
  • [Journal-full-title] Neuroreport
  • [ISO-abbreviation] Neuroreport
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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19. Lee JH, Kwon BS, Ha IS, Cheong HI, Moon KC, Ahn HS, Choi Y: Nephrotic syndrome in a child after umbilical-cord-blood transplantation. Pediatr Nephrol; 2006 Sep;21(9):1312-7
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  • We report a 12-year-old girl who developed nephrotic syndrome 6 months after umbilical-cord-blood transplantation (UCBT) for acute lymphoblastic leukemia (L2).
  • [MeSH-minor] Adolescent. Adult. Child. Female. Graft vs Host Disease / immunology. Graft vs Host Disease / prevention & control. Humans. Immunosuppressive Agents / pharmacology. Male. Middle Aged. Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy

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  • (PMID = 16791603.001).
  • [ISSN] 0931-041X
  • [Journal-full-title] Pediatric nephrology (Berlin, Germany)
  • [ISO-abbreviation] Pediatr. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
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20. Mkrtchyan H, Glaser M, Gross M, Wedding U, Hoffken K, Liehr T, Karst C, Aroutiounian R: Multicolor-FISH applied to resolve complex chromosomal changes in a case of T-ALL (FAB L2). Cytogenet Genome Res; 2006;114(3-4):270-3
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  • [Title] Multicolor-FISH applied to resolve complex chromosomal changes in a case of T-ALL (FAB L2).
  • We report on a patient with a clinically diagnosed acute lymphoblastic leukemia (ALL) with partial unrecorded complex translocation events especially involving chromosomes 5, 9 and 18.
  • [MeSH-major] Chromosome Aberrations. In Situ Hybridization, Fluorescence / methods. Leukemia-Lymphoma, Adult T-Cell / genetics. Leukemia-Lymphoma, Adult T-Cell / pathology
  • [MeSH-minor] Adolescent. Blast Crisis / genetics. Blast Crisis / pathology. Chromosome Mapping. Humans. Karyotyping. Male. Recurrence

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  • [Copyright] Copyright 2006 S. Karger AG, Basel.
  • (PMID = 16954665.001).
  • [ISSN] 1424-859X
  • [Journal-full-title] Cytogenetic and genome research
  • [ISO-abbreviation] Cytogenet. Genome Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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21. Balamurugan S, Sugapriya D, Shanthi P, Thilaka V, Venkatadesilalu S, Pushpa V, Madhavan M: Multidrug resistance 1 gene expression and AgNOR in childhood acute leukemias. Indian J Hematol Blood Transfus; 2007 Dec;23(3-4):73-8
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  • [Title] Multidrug resistance 1 gene expression and AgNOR in childhood acute leukemias.
  • We have studied MDR1 expression and AgNORS in 41 cases of acute leukemia in children.
  • In this study, AgNOR counts in patients with acute lymphoblastic leukemia (ALL) L2 subtype (FAB classification) were significantly higher as compared to the ALL L1 subtype.
  • Similarly, mean AgNOR count in the acute myeloid Leukemia (AML) M2 subtype was significantly higher as compared to the ALL L1 subtype.
  • However, there was no correlation between AgNOR and treatment outcome or between AgNOR counts and MDR1 expression in any of the subtypes of acute leukemia included in this series.
  • In ALL, our study has shown no difference in remission induction between MDR1 positive and MDR1 negative cases.

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  • (PMID = 23100919.001).
  • [ISSN] 0971-4502
  • [Journal-full-title] Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion
  • [ISO-abbreviation] Indian J Hematol Blood Transfus
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3453125
  • [Keywords] NOTNLM ; Acute leukemia / AgNOR / Multidrug Resistance 1 / P-glycoprotein
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22. Khan AU, Sheikh MU, Intekhab K: Pre-existing malnutrition and treatment outcome in children with acute lymphoblastic leukaemia. J Pak Med Assoc; 2006 Apr;56(4):171-3
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  • [Title] Pre-existing malnutrition and treatment outcome in children with acute lymphoblastic leukaemia.
  • OBJECTIVE: To assess the effects of pre-existing malnutrition on the treatment outcome of children with acute lymphoblastic leukaemia.
  • METHODS: One hundred and sixty three patients with Acute Lymphoblastic Leukaemia (ALL) below the age of 14 years with L1 and L2 FAB morphology were included in this study.
  • CONCLUSION: Pre-Existing malnutrition adversely effects the treatment outcome in children with Acute Lymphoblastic Leukaemia (ALL).
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols. Malnutrition / complications. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Treatment Outcome
  • [MeSH-minor] Acute Disease. Adolescent. Child. Child, Preschool. Humans. Infant. Infant, Newborn. Prospective Studies. Risk Assessment. Time Factors

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  • (PMID = 16711338.001).
  • [ISSN] 0030-9982
  • [Journal-full-title] JPMA. The Journal of the Pakistan Medical Association
  • [ISO-abbreviation] J Pak Med Assoc
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Pakistan
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23. Sucić M, Batinić D, Zadro R, Mrsić S, Labar B: [Cytomorphology of acute mixed leukemia]. Acta Med Croatica; 2008 Oct;62(4):379-85
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  • [Title] [Cytomorphology of acute mixed leukemia].
  • Biphenotypic acute leukemias (AL) with blasts expressing both myeloid and lymphoid antigens are grouped with undifferentiated AL and bilineal AL in the group of AL of ambiguous lineage.
  • Not all AL with myeloid and lymphoid antigens (ALMy+Ly) are true biphenotypic AL.
  • According to EGIL scoring system, true biphenotypic ALMy+Ly are those with a sum of antigens 2 or more points for both myeloid and lymphoid lineage or for B and T lineage.
  • RESULTS AND DISCUSSION: In the group of 169 adult AL patients, 116 were cytomorphologically classified as acute myeloblastic leukemias (AML), 35 as acute lymphoblastic leukemias (ALL) and 18 as acute undifferentiated leukemias (ANLM).
  • In 6 (3.4%) of 169 AL patients, blasts expressed both myeloid and lymphoid antigens.
  • In 64 patients cytomorphologically classified into AML subgroup out of 102 AL patients, there were 15 (14.7%/102; 23.4%/64) AML with lymphoid antigens (AMLLy+).
  • In one ANLM,My+ out of 169 AL and also one ANLM,My+ out of 102 AL, blasts were cytomorphologically undifferentiated; in 3 ALLMy+ of 102 AL blasts expressed lymphoid morphology.
  • According to EGIL scoring system, among 15 AMLLy+ of 102 AL there were 4 true biphenotypic ALMy+Ly (1 M1, 2 M3, 1 M4), and in 4 ALMy+Ly with undifferentiated and lymphoid morphology there were 2 true biphenotypic AL (1 L2; 1 ANLM).
  • These observations are consistent with other studies and WHO determinations indicating that the majority of true biphenotypic leukemias are associated with immature monoblastic or myeloid cytomorphology or with lymphoid or undifferentiated characteristics, but may also express any AML cytomorphology type.
  • [MeSH-major] Leukemia, Biphenotypic, Acute / pathology
  • [MeSH-minor] Acute Disease. Humans. Immunophenotyping. Leukemia, Myeloid, Acute / classification. Leukemia, Myeloid, Acute / immunology. Leukemia, Myeloid, Acute / pathology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / classification. Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology

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  • (PMID = 19205415.001).
  • [ISSN] 1330-0164
  • [Journal-full-title] Acta medica Croatica : c̆asopis Hravatske akademije medicinskih znanosti
  • [ISO-abbreviation] Acta Med Croatica
  • [Language] hrv
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Croatia
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