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6. Feller M, Adam M, Zwahlen M, Brazzola P, Niggli F, Kuehni C, Swiss Pediatric Oncology Group (SPOG), Swiss National Cohort (SNC): Family characteristics as risk factors for childhood acute lymphoblastic leukemia: a population-based case-control study. PLoS One; 2010;5(10)
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  • [Title] Family characteristics as risk factors for childhood acute lymphoblastic leukemia: a population-based case-control study.
  • BACKGROUND: To date, few risk factors for childhood acute lymphoblastic leukemia (ALL) have been confirmed and the scientific literature is full of controversial "evidence."
  • We examined if family characteristics, particularly maternal and paternal age and number of older siblings, were risk factors for childhood acute lymphoblastic leukemia (ALL).
  • METHODOLOGY/PRINCIPAL FINDINGS: In this population-based nationwide matched case-control study, patients 0-14 years of age with ALL diagnosed 1991-2006 and registered in the Swiss Childhood Cancer Registry were linked with their census records of 1990 and 2000.
  • [MeSH-major] Family. Population Surveillance. Precursor Cell Lymphoblastic Leukemia-Lymphoma / epidemiology
  • [MeSH-minor] Adolescent. Case-Control Studies. Child. Child, Preschool. Female. Humans. Infant. Male. Registries. Risk Factors. Switzerland / epidemiology


7. Spasova MI, Stoyanova AA, Moumdjiev IN, Dimitrov HK: Childhood acute lymphoblastic leukemia presenting with osteoarticular syndrome--characteristics and prognosis. Folia Med (Plovdiv); 2009 Jan-Mar;51(1):50-5
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  • [Title] Childhood acute lymphoblastic leukemia presenting with osteoarticular syndrome--characteristics and prognosis.
  • Children with leukemia often present with osteoarticular syndrome as a first complaint thus mimicking juvenile idiopathic arthritis.
  • The objective of the present study was to determine the frequency of osteoarticular syndrome at the onset of acute lymphoblastic leukemia in childhood, the clinical and laboratory specificity of such patients and the prognostic value of osteoarticular syndrome as an initial symptom.
  • PATIENTS AND METHODS: We studied 60 children with acute lymphoblastic leukemia at a mean age of 5 +/- 0.5 years between February 2002 and October 2007.
  • RESULTS: Osteoarticular syndrome was present as an initial symptom of leukemia in 18 (30.5%) patients.
  • Event-free survival in patients with osteoarticular syndrome is comparable to that of the remaining group of acute lymphoblastic leukemia patients.
  • [MeSH-major] Arthritis, Juvenile / diagnosis. Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
  • [MeSH-minor] Adolescent. Bulgaria / epidemiology. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Joints / pathology. Joints / physiopathology. Leukocyte Count. Male. Prognosis. Survival Rate


8. He GS, Zhang XH, Yao L, Zhang R, Chen ZX, Wu DP, Sun AN, Jin ZM, Qiu HY, Hu XH: [Acute T cells lymphoblastic leukemia with a t(1;19)(q23;p13) and E2A-PBX1 in an adult: one case report and literature review]. Zhonghua Xue Ye Xue Za Zhi; 2009 Oct;30(10):675-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Acute T cells lymphoblastic leukemia with a t(1;19)(q23;p13) and E2A-PBX1 in an adult: one case report and literature review].
  • OBJECTIVE: To report a case of T cell acute lymphoblastic leukemia (ALL) with t(1;19)(q23;pl3) and E2A-PBX1 fusion gene, which is a characteristic translocation of childhood B cell ALL (B-ALL).
  • CONCLUSION: t(1;19)E2A-PBX1(+) can be implicated in adult T-ALL, besides childhood B-ALL.
  • [MeSH-major] Homeodomain Proteins / genetics. Oncogene Proteins, Fusion / genetics. Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / genetics. Translocation, Genetic

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  • (PMID = 19954663.001).
  • [ISSN] 0253-2727
  • [Journal-full-title] Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
  • [ISO-abbreviation] Zhonghua Xue Ye Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / Oncogene Proteins, Fusion; 146150-85-8 / E2A-Pbx1 fusion protein
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9. Hamouda F, El-Sissy AH, Radwan AK, Hussein H, Gadallah FH, Al-Sharkawy N, Sedhom E, Ebeid E, Salem SI: Correlation of karyotype and immunophenotype in childhood acute lymphoblastic leukemia; experience at the National Cancer Institute, Cairo University, Egypt. J Egypt Natl Canc Inst; 2007 Jun;19(2):87-95
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  • [Title] Correlation of karyotype and immunophenotype in childhood acute lymphoblastic leukemia; experience at the National Cancer Institute, Cairo University, Egypt.
  • [MeSH-major] Antigens, Neoplasm / analysis. Immunophenotyping / methods. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics. Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology
  • [MeSH-minor] Case-Control Studies. Child. Chromosome Banding. Diploidy. Egypt. Female. Flow Cytometry. Follow-Up Studies. Humans. In Situ Hybridization, Fluorescence. Karyotyping. Male. Prognosis. Retrospective Studies. Universities


10. Yeoh AE, Lu Y, Chan JY, Chan YH, Ariffin H, Kham SK, Quah TC: Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: results from the Malaysia-Singapore ALL Study Group. Leuk Res; 2010 Mar;34(3):276-83
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  • [Title] Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: results from the Malaysia-Singapore ALL Study Group.
  • To study genetic epidemiology of childhood acute lymphoblastic leukemia (ALL) in the Chinese and Malays, we investigated 10 polymorphisms encoding carcinogen- or folate-metabolism and transport.
  • [MeSH-major] Genetic Predisposition to Disease. Precursor Cell Lymphoblastic Leukemia-Lymphoma / ethnology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • [MeSH-minor] Adolescent. Asian Continental Ancestry Group. Child. Child, Preschool. Female. Genotype. Humans. Infant. Infant, Newborn. Malaysia / epidemiology. Male. Polymorphism, Single Nucleotide. Sex Characteristics. Singapore / epidemiology. Young Adult

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  • [Copyright] Copyright (c) 2009 Elsevier Ltd. All rights reserved.
  • [CommentIn] Leuk Res. 2010 Mar;34(3):269-71 [19716175.001]
  • (PMID = 19651439.001).
  • [ISSN] 1873-5835
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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11. Bury J, Hurt C, Roy A, Cheesman L, Bradburn M, Cross S, Fox J, Saha V: LISA: a web-based decision-support system for trial management of childhood acute lymphoblastic leukaemia. Br J Haematol; 2005 Jun;129(6):746-54
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  • [Title] LISA: a web-based decision-support system for trial management of childhood acute lymphoblastic leukaemia.
  • Continuation chemotherapy is a key component of the treatment of childhood acute lymphoblastic leukaemia.
  • A web-based decision-support system (Leukaemia Intervention Scheduling and Advice, 'LISA') was designed to facilitate access to FBC information across geographical locations and to assist with dosage adjustments.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Clinical Trials as Topic / methods. Decision Support Systems, Clinical. Internet. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • [MeSH-minor] Child. Clinical Protocols. Cross-Over Studies. Drug Administration Schedule. Drug Therapy, Computer-Assisted / methods. Guideline Adherence. Humans

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  • (PMID = 15953000.001).
  • [ISSN] 0007-1048
  • [Journal-full-title] British journal of haematology
  • [ISO-abbreviation] Br. J. Haematol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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12. Tham EH, Tay SK, Low PS: Factors predictive of outcome in childhood stroke in an Asian population. Ann Acad Med Singapore; 2009 Oct;38(10):876-81
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  • [Title] Factors predictive of outcome in childhood stroke in an Asian population.
  • The aim of this study was to evaluate the epidemiology of childhood stroke in a tertiary paediatric unit in Singapore and to assess factors influencing outcome in these children.
  • MATERIALS AND METHODS: A retrospective case-note review of all childhood strokes presenting to the Children's Medical Institute (CMI) at the National University Hospital (NUH), Singapore between October 1999 and May 2006.
  • [MeSH-minor] Adolescent. Age Factors. Asian Continental Ancestry Group. Brain Ischemia / epidemiology. Brain Ischemia / etiology. Brain Ischemia / rehabilitation. Cerebral Hemorrhage / etiology. Child. Child, Preschool. Developmental Disabilities / etiology. Female. Humans. Infant. Intracranial Arteriovenous Malformations / complications. Length of Stay / statistics & numerical data. Male. Neuropsychological Tests. Prognosis. Retrospective Studies. Risk Assessment. Risk Factors. Singapore / epidemiology. Treatment Outcome. Vascular Diseases / complications

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  • (PMID = 19890579.001).
  • [ISSN] 0304-4602
  • [Journal-full-title] Annals of the Academy of Medicine, Singapore
  • [ISO-abbreviation] Ann. Acad. Med. Singap.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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13. Jain N, Brouwers P, Okcu MF, Cirino PT, Krull KR: Sex-specific attention problems in long-term survivors of pediatric acute lymphoblastic leukemia. Cancer; 2009 Sep 15;115(18):4238-45
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  • [Title] Sex-specific attention problems in long-term survivors of pediatric acute lymphoblastic leukemia.
  • BACKGROUND: Neurocognitive problems are a frequent outcome of chemotherapy for pediatric leukemia, although individual differences exist in patient outcome.
  • The purpose of this study was to evaluate the pattern of attention problems in male and female long-term survivors of pediatric acute lymphoblastic leukemia (ALL).
  • CONCLUSIONS: The results of this study suggest that children diagnosed with and treated for pediatric ALL perform poorly on select measures of attention and executive control, and that this performance is influenced by sex and treatment intensity.
  • [MeSH-major] Attention. Cognition Disorders / etiology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / psychology. Sex Characteristics. Survivors / psychology
  • [MeSH-minor] Age of Onset. Child. Female. Humans. Male

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  • [Copyright] Copyright (c) 2009 American Cancer Society.
  • (PMID = 19536898.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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4. Hernández Sánchez JE, Gómez Vegas A, Blázquez Izquierdo J, Grimalt Alvarez J, Pérez Contín MJ, Rabadán Marina M, San José Manso L, Alonso Prieto M, Pérez Romero N, Silmi Moyano A: [En bloc transplantation of pediatric donor kidneys to adult receptors]. Arch Esp Urol; 2007 Mar;60(2):137-46
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  • [Title] [En bloc transplantation of pediatric donor kidneys to adult receptors].
  • [Transliterated title] Trasplante en bloque de riñones procedentes de donantes pediatricos en receptores adultos.
  • OBJECTIVES: Analysis of all pediatric donor en bloc transplants to adult receptors performed in our department.
  • RESULTS: There were significant differences in terms of nonfunctioning kidneys and delayed graft function, more frequent in pediatric en bloc and adult transplants, respectively.
  • Pediatric kidneys provided better renal function and less proteinuria.
  • One and five-year graft survivals were 83.56% and 8 1.47% for pediatric donor kidneys, and 91.50% and 86.99% for adult donor kidneys.
  • CONCLUSIONS: Pediatric donor en bloc transplants have an excellent survival and function in the middle and long-term.
  • Vascular complications are the main cause of pediatric donor graft loss.
  • The adoption of a pediatric donor en bloc transplant program increases the transplant activity.
  • [MeSH-minor] Adult. Age Factors. Child. Child, Preschool. Female. Graft Survival. Humans. Immunosuppressive Agents / therapeutic use. Infant. Kaplan-Meier Estimate. Male. Middle Aged. Postoperative Complications / epidemiology. Retrospective Studies. Spain. Survival Analysis. Tissue Donors. Tissue and Organ Procurement. Treatment Outcome

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  • (PMID = 17484481.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
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15. Kamiya H, Nakano T, Inoue M, Kamiya H, Abd TT, Patel M, Orenstein WA, Parashar UD: A retrospective evaluation of hospitalizations for acute gastroenteritis at 2 sentinel hospitals in central Japan to estimate the health burden of rotavirus. J Infect Dis; 2009 Nov 1;200 Suppl 1:S140-6
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  • [Title] A retrospective evaluation of hospitalizations for acute gastroenteritis at 2 sentinel hospitals in central Japan to estimate the health burden of rotavirus.
  • METHODS: To describe the epidemiology of severe rotavirus disease among Japanese children aged <5 years, we examined retrospective demographic, clinical, and laboratory data from the period 2003-2007 for children hospitalized with acute gastroenteritis (AGE) at 2 sentinel hospitals in Japan.
  • RESULTS: At each of the 2 hospitals, 17%-21% of all pediatric hospitalizations were for AGE.
  • [MeSH-minor] Acute Disease. Humans. Japan / epidemiology. Retrospective Studies. Seasons

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  • (PMID = 19817592.001).
  • [ISSN] 1537-6613
  • [Journal-full-title] The Journal of infectious diseases
  • [ISO-abbreviation] J. Infect. Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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