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1. Purtscher K: [Trauma in childhood--risks for the child's development]. Psychiatr Danub; 2008 Dec;20(4):513-20
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  • [Title] [Trauma in childhood--risks for the child's development].
  • [Transliterated title] Traumatisierung in der Kindheit--Folgen für die Entwicklung.
  • Studies of early childhood traumatic experiences have clearly established a causal relationship between the experience of childhood psychic trauma and long-term effects on cognitive emotional und social development.
  • More intermediate-term consequences of childhood trauma are likely to reside in higher rates of risk for the development of conduct disorders, higher rates of teenage pregnancy, school droop out, and involvement with the juvenile court jurisdiction because of law violations.
  • To meet a child needs in daily life after traumatic experience different times of support and therapy are needed and involves parents, teachers, social workers and therapists as well.
  • [MeSH-minor] Adolescent. Child. Conduct Disorder / diagnosis. Conduct Disorder / psychology. Conduct Disorder / therapy. Emotions. Female. Humans. Internal-External Control. Juvenile Delinquency / prevention & control. Juvenile Delinquency / psychology. Male. Patient Care Team. Pregnancy. Pregnancy in Adolescence / prevention & control. Pregnancy in Adolescence / psychology. Risk Factors

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  • (PMID = 19011593.001).
  • [ISSN] 0353-5053
  • [Journal-full-title] Psychiatria Danubina
  • [ISO-abbreviation] Psychiatr Danub
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Croatia
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2. Grassi-Oliveira R, Stein LM, Pezzi JC: [Translation and content validation of the Childhood Trauma Questionnaire into Portuguese language]. Rev Saude Publica; 2006 Apr;40(2):249-55

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Translation and content validation of the Childhood Trauma Questionnaire into Portuguese language].
  • [Transliterated title] Tradução e validação de conteúdo da versão em português do Childhood Trauma Questionnaire.
  • OBJECTIVE: The Childhood Trauma Questionnaire is a self-applied instrument for adolescents and adults to assess childhood abuse.
  • [MeSH-major] Child Abuse / diagnosis. Surveys and Questionnaires

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  • (PMID = 16583035.001).
  • [ISSN] 0034-8910
  • [Journal-full-title] Revista de saúde pública
  • [ISO-abbreviation] Rev Saude Publica
  • [Language] por
  • [Publication-type] English Abstract; Journal Article; Validation Studies
  • [Publication-country] Brazil
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3. Tomás Vila M, Miralles Torres A, Beseler Soto B: [Spanish version of the Pediatric Sleep Questionnaire (PSQ). A useful instrument in investigation of sleep disturbances in childhood. Reliability analysis]. An Pediatr (Barc); 2007 Feb;66(2):121-8
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  • [Title] [Spanish version of the Pediatric Sleep Questionnaire (PSQ). A useful instrument in investigation of sleep disturbances in childhood. Reliability analysis].
  • [Transliterated title] Versión española del Pediatric Sleep Questionnaire. Un instrumento útil en la investigación de los trastornos del sueño en la infancia. Análisis de su fiabilidad.
  • The Pediatric Sleep Questionnaire (PSQ) has two versions: a shorter one, which has been validated for sleep-related breathing disorders, and an extended version, which deals with a wider range of sleep disturbances.
  • [MeSH-minor] Child. Humans. Language. Reproducibility of Results

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  • (PMID = 17306097.001).
  • [ISSN] 1695-4033
  • [Journal-full-title] Anales de pediatría (Barcelona, Spain : 2003)
  • [ISO-abbreviation] An Pediatr (Barc)
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Validation Studies
  • [Publication-country] Spain
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4. Styczynski J, Kurylak A, Wysocki M: Cytotoxicity of cortivazol in childhood acute lymphoblastic leukemia. Anticancer Res; 2005 May-Jun;25(3B):2253-8
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  • [Title] Cytotoxicity of cortivazol in childhood acute lymphoblastic leukemia.
  • BACKGROUND: Glucocorticoids are the most important group of drugs used in the treatment of childhood acute lymphoblastic leukemia (ALL), however, resistance to this group remains the main obstacle in curing the disease.
  • AIM: Analysis of ex vivo sensitivity to cortivazol and other glucocorticoids in childhood acute lymphoblastic leukemia, as well as the relationship to anticancer therapy outcome.
  • CONCLUSION: Cortivazol has potent antileukemic activity in childhood ALL.
  • [MeSH-major] Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Pregnatrienes / pharmacology
  • [MeSH-minor] Adolescent. Cell Cycle / drug effects. Child. Child, Preschool. Drug Resistance, Neoplasm. Female. Glucocorticoids / pharmacology. Humans. Infant. Lymphocytes / drug effects. Lymphocytes / pathology. Male. Prednisolone / pharmacology. Prognosis

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  • (PMID = 16158972.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Glucocorticoids; 0 / Pregnatrienes; 9PHQ9Y1OLM / Prednisolone; YM183K0H63 / cortivazol
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5. Walter U, Kramer S, Röbl M: [Physical (in)activity in childhood and adolescence]. Dtsch Med Wochenschr; 2005 Dec 16;130(50):2876-8
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  • [Title] [Physical (in)activity in childhood and adolescence].
  • [Transliterated title] Körperliche (In)Aktivität in Kindheit und Jugend.
  • Physical inactivity in childhood and youth is related with coronary heart disease risk factors and higher prevalence of obesity.
  • [MeSH-minor] Adolescent. Body Mass Index. Child. Child, Preschool. Germany. Health Services Needs and Demand / trends. Humans. Motor Skills. Physical Education and Training / trends. Physical Endurance. Physical Fitness


6. Carvajal-Urueña I, García-Marcos L, Busquets-Monge R, Morales Suárez-Varela M, García de Andoin N, Batlles-Garrido J, Blanco-Quirós A, López-Silvarrey A, García-Hernández G, Guillén-Grimaj F, González-Díaz C, Bellido-Blasco J: [Geographic variation in the prevalence of asthma symptoms in Spanish children and adolescents. International Study of Asthma and Allergies in Childhood (ISAAC) Phase 3, Spain]. Arch Bronconeumol; 2005 Dec;41(12):659-66
MedlinePlus Health Information. consumer health - Asthma in Children.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Geographic variation in the prevalence of asthma symptoms in Spanish children and adolescents. International Study of Asthma and Allergies in Childhood (ISAAC) Phase 3, Spain].
  • [Transliterated title] Variaciones geograficas en la prevalencia de sintomas de asma en los ninos y adolescentes espanoles. International Study of Asthma and Allergies in Childhood (ISAAC) fase III Espana.
  • POPULATION AND METHODS: In 2001 and 2002, the Spanish arm of the International Study of Asthma and Allergies in Childhood (ISAAC) Phase 3 collected information on 28 445 children in the age bracket of 6-7 years in 10 metropolitan areas (A Coruña, Asturias, Barcelona, Bilbao, Cartagena, Castellón, Madrid, Pamplona, San Sebastián, and Valencia) and on 31 257 adolescents in the bracket 13-14 years in 11 areas (the previously named areas plus Valladolid).
  • [MeSH-minor] Adolescent. Age Distribution. Child. Humans. Prevalence. Spain / epidemiology. Surveys and Questionnaires

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  • (PMID = 16373042.001).
  • [ISSN] 0300-2896
  • [Journal-full-title] Archivos de bronconeumología
  • [ISO-abbreviation] Arch. Bronconeumol.
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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7. Tesch FC, Oliveira BH, Leão A: [Semantic equivalence of the Brazilian version of the Early Childhood Oral Health Impact Scale]. Cad Saude Publica; 2008 Aug;24(8):1897-909
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  • [Title] [Semantic equivalence of the Brazilian version of the Early Childhood Oral Health Impact Scale].
  • [Transliterated title] Equivalência semântica da versão em português do instrumento Early Childhood Oral Health Impact Scale.
  • The North American instrument Early Childhood Oral Health Impact Scale (ECOHIS) was created to assess the oral health-related quality of life of preschool children and their families.
  • [MeSH-minor] Brazil. Child. Child, Preschool. Cross-Cultural Comparison. Cultural Characteristics. Humans

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  • (PMID = 18709230.001).
  • [ISSN] 1678-4464
  • [Journal-full-title] Cadernos de saúde pública
  • [ISO-abbreviation] Cad Saude Publica
  • [Language] por
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] Brazil
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8. La Scala CS, Naspitz CK, Solé D: [Adaptation and validation of the Pediatric Asthma Quality of Life Questionnaire (PAQLQ) in Brazilian asthmatic children and adolescents]. J Pediatr (Rio J); 2005 Jan-Feb;81(1):54-60
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  • [Title] [Adaptation and validation of the Pediatric Asthma Quality of Life Questionnaire (PAQLQ) in Brazilian asthmatic children and adolescents].
  • [Transliterated title] Adaptação e validação do Pediatric Asthma Quality of Life Questionnaire (PAQLQ-A) em crianças e adolescentes brasileiros com asma.
  • OBJECTIVES: To translate the Pediatric Asthma Quality of Life Questionnaire (PAQLQ) into Portuguese and adapt it to the Brazilian context, for use in children and adolescents with asthma and to validate the adapted version of the questionnaire (PAQLQ-A).
  • [MeSH-minor] Adolescent. Brazil. Child. Female. Humans. Male. Reproducibility of Results. Severity of Illness Index. Translating

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  • [CommentIn] J Pediatr (Rio J). 2005 May-Jun;81(3):268-9; author reply 269-70 [15951917.001]
  • (PMID = 15742087.001).
  • [ISSN] 0021-7557
  • [Journal-full-title] Jornal de pediatria
  • [ISO-abbreviation] J Pediatr (Rio J)
  • [Language] por
  • [Publication-type] English Abstract; Journal Article; Validation Studies
  • [Publication-country] Brazil
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9. Nitzko S: [Overweight and obesity in childhood and adolescence]. Prax Kinderpsychol Kinderpsychiatr; 2010;59(10):831-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Overweight and obesity in childhood and adolescence].
  • [Transliterated title] Ubergewicht und Adipositas in Kindheit und Jugend.
  • Firstly, essential developmental aspects of the focused periods of life, namely childhood and adolescence, are discussed.
  • Furthermore, different issues of overweight and obesity in childhood and adolescence are highlighted.
  • Finally, the focus is on the therapy of obesity in childhood and adolescence.
  • [MeSH-minor] Adolescent. Causality. Child. Combined Modality Therapy. Comorbidity. Cooperative Behavior. Cross-Sectional Studies. Female. Germany. Humans. Interdisciplinary Communication. Male. Mental Disorders / epidemiology. Mental Disorders / psychology. Self Concept

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  • (PMID = 21290853.001).
  • [ISSN] 0032-7034
  • [Journal-full-title] Praxis der Kinderpsychologie und Kinderpsychiatrie
  • [ISO-abbreviation] Prax Kinderpsychol Kinderpsychiatr
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
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10. Neumann E, Tress W: [Close relationships in childhood and adulthood from the viewpoint of structural analysis of social behavior (SASB) and attachment theory]. Psychother Psychosom Med Psychol; 2007 Mar-Apr;57(3-4):145-53
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  • [Title] [Close relationships in childhood and adulthood from the viewpoint of structural analysis of social behavior (SASB) and attachment theory].
  • [Transliterated title] Enge Beziehungen in Kindheit und Erwachsenenalter aus der Sicht der Strukturalen Analyse Sozialen Verhaltens (SASB) und der Bindungstheorie.
  • The focus is on the most important relationships during life-span: relationships with mother and father in childhood, which were measured retrospectively, and romantic relationships in adulthood.
  • [MeSH-minor] Adult. Anxiety / psychology. Child. Family Relations. Humans. Personal Autonomy. Psychophysiologic Disorders / psychology. Retrospective Studies. Surveys and Questionnaires

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  • (PMID = 17211774.001).
  • [ISSN] 0937-2032
  • [Journal-full-title] Psychotherapie, Psychosomatik, medizinische Psychologie
  • [ISO-abbreviation] Psychother Psychosom Med Psychol
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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11. Voll R: [A rare differential diagnosis of a somatoform autonomous disorder of the gastro-intestinal tract: the hepatocellular liver carcinoma in childhood]. Z Kinder Jugendpsychiatr Psychother; 2008 Jul;36(4):275-8
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  • [Title] [A rare differential diagnosis of a somatoform autonomous disorder of the gastro-intestinal tract: the hepatocellular liver carcinoma in childhood].
  • [Transliterated title] Eine seltene Differenzialdiagnose somatoformer autonomer Funktionsstörung des Abdominaltraktes: das hepatozelluläre Leberkarzinom in der Kindheit.
  • OBJECTIVES: A severely ill 11-year-old boy came to the child psychiatric outpatient department of the Fachkrankenhaus Neckargemünd with the diagnosis of a somatoform disorder.
  • CONCLUSIONS: The symptoms of the hepatocellular carcinoma, which rarely occurs in childhood, can perfectly mimic those of a somatoform disorder of the gastro-intestinal tract.
  • [MeSH-minor] Child. Child Reactive Disorders / diagnosis. Child Reactive Disorders / psychology. Child Reactive Disorders / therapy. Combined Modality Therapy. Diagnosis, Differential. Family Therapy. Follow-Up Studies. Hepatectomy / psychology. Humans. Male. Neuropsychological Tests. Psychotherapy. Referral and Consultation. Sick Role

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  • (PMID = 18654959.001).
  • [ISSN] 1422-4917
  • [Journal-full-title] Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie
  • [ISO-abbreviation] Z Kinder Jugendpsychiatr Psychother
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Switzerland
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12. Brainin E, Teicher S: [The terror from the outside--child survivors of the Spiegelgrund traumatic experiences in childhood and their effects]. Prax Kinderpsychol Kinderpsychiatr; 2009;58(7):530-52
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  • [Title] [The terror from the outside--child survivors of the Spiegelgrund traumatic experiences in childhood and their effects].
  • [Transliterated title] Terror von aussen am Beispiel Spiegelgrund Traumatische Erfahrungen in der Kindheit und deren Folgen.
  • The overcoming and dealing with the terrible past during childhood were discussed as well as the reactions to the interviews of the members of the study group.
  • The theoretical frame was Anna Freud's work on child survivors of the Theresienstadt concentration camp: "An Experiment in Group Upbringing": Different factors for the survival and the working through afterwards are discussed as well as the different psychoanalytical trauma concepts.
  • The former experiences of the children in institutions of the social administration in Austria differ from the experiences of Jewish child survivors.
  • [MeSH-minor] Adolescent. Austria. Child. Germany. History, 20th Century. Humans

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  • (PMID = 19911766.001).
  • [ISSN] 0032-7034
  • [Journal-full-title] Praxis der Kinderpsychologie und Kinderpsychiatrie
  • [ISO-abbreviation] Prax Kinderpsychol Kinderpsychiatr
  • [Language] ger
  • [Publication-type] English Abstract; Historical Article; Journal Article
  • [Publication-country] Germany
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13. Schmidt-Bacher AE, Kahlert C, Kolling G: [Accuracy of two autorefractors--Pediatric Autorefractor plusoptiX and Retinomax--in cycloplegic children in comparison to retinoscopy]. Klin Monbl Augenheilkd; 2010 Oct;227(10):792-7
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  • [Title] [Accuracy of two autorefractors--Pediatric Autorefractor plusoptiX and Retinomax--in cycloplegic children in comparison to retinoscopy].
  • [Transliterated title] Zur Messung der objektiven Refraktion in Zykloplegie im Kindesalter mit Skiaskopie und automatischer Refraktometrie mit dem Pediatric Autorefractor und dem Retinomax.
  • In a prospective study we compared readings from two hand-held photorefractors, the Pediatric Autorefractor and the Retinomax, to those from retinoscopy.
  • All patients underwent standardised cycloplegia measurements first by the Pediatric Autorefractor plusoptiX A 08 in 1 metre working distance, then adding an infrared filter to reduce interferences, followed by the Retinomax K-plus 3 in 5 cm working distance and retinoscopy as reference on the right eye.
  • RESULTS: Spherical equivalents measured by the Pediatric Autorefractor plusoptiX A 08 coincided in 51.2% with retinoscopy (± 0.5 D).
  • The Pediatric Autorefractor is not suited for everyday clinical routine due to a low success rate of 50% and tight measuring range of + 5.0 to -7.0 D in spherical equivalents.
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Equipment Design. Female. Humans. Infant. Male. Ophthalmic Solutions. Sensitivity and Specificity

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  • [Copyright] © Georg Thieme Verlag KG Stuttgart · New York.
  • [CommentIn] Klin Monbl Augenheilkd. 2012 Oct;229(10):1045; author reply 1046 [23096147.001]
  • (PMID = 20963682.001).
  • [ISSN] 1439-3999
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Mydriatics; 0 / Ophthalmic Solutions; I76F4SHP7J / Cyclopentolate
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14. Lampert T: [Setting the course early: relevance of childhood and adolescence for health in later life]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz; 2010 May;53(5):486-97
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  • [Title] [Setting the course early: relevance of childhood and adolescence for health in later life].
  • [Transliterated title] Frühe Weichenstellung: Zur Bedeutung der Kindheit und Jugend für die Gesundheit im späteren Leben.
  • The article examines the importance of childhood and adolescence for health in later life against the background of the population-aging process and the debate on the social challenges expected to result from this process.
  • [MeSH-major] Adolescent Development. Child Development. Chronic Disease / epidemiology. Disabled Persons / statistics & numerical data. Population Dynamics
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Forecasting. Germany. Health Promotion / trends. Health Services Needs and Demand / trends. Humans. Infant. Infant, Newborn. Middle Aged. Pregnancy. Primary Prevention / trends. Risk Factors. Young Adult


15. Hardt J, Hoffmann SO: [Childhood in flux--Part I: Ancient world until modern times]. Prax Kinderpsychol Kinderpsychiatr; 2006;55(4):271-9
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  • [Title] [Childhood in flux--Part I: Ancient world until modern times].
  • [Transliterated title] Kindheit im Wandel--Teil I: Antike bis zur Neuzeit.
  • Scientific research on childhood constitutes a relatively new field.
  • Until medieval times, a child's life did not count for much, that is, as long as the child was not the beneficiary of an inheritance.
  • Despite Rousseau's idealistic concept of education as a kind of identification process for the child, he put his own five children into the foundling hospital of Paris; he was bothered by them when writing.
  • Up to the beginning of the 19th century, the value of a child was determined by his or her ability to work.
  • [MeSH-major] Child Abuse / history. Child Care / history. Child, Abandoned / history. Employment / history. Infanticide / history. Social Values
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Europe. Female. History, 15th Century. History, 16th Century. History, 17th Century. History, 18th Century. History, 19th Century. History, Ancient. History, Medieval. Humans. Infant. Male. United States

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  • (PMID = 17436560.001).
  • [ISSN] 0032-7034
  • [Journal-full-title] Praxis der Kinderpsychologie und Kinderpsychiatrie
  • [ISO-abbreviation] Prax Kinderpsychol Kinderpsychiatr
  • [Language] ger
  • [Publication-type] English Abstract; Historical Article; Journal Article
  • [Publication-country] Germany
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16. Wingenfeld K, Spitzer C, Mensebach C, Grabe HJ, Hill A, Gast U, Schlosser N, Höpp H, Beblo T, Driessen M: [The German version of the Childhood Trauma Questionnaire (CTQ): preliminary psychometric properties]. Psychother Psychosom Med Psychol; 2010 Nov;60(11):442-50
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  • [Title] [The German version of the Childhood Trauma Questionnaire (CTQ): preliminary psychometric properties].
  • [Transliterated title] Die deutsche Version des Childhood Trauma Questionnaire (CTQ): Erste Befunde zu den psychometrischen Kennwerten.
  • Given the relevance of child maltreatment for the development and treatment of many mental disorders, the objective of our study was the psychometric evaluation of the German version of the Childhood Trauma Questionnaire (CTQ).
  • The psychometric properties of the German version of the CTQ were similar to the American original; it proved to be a reliable and valid screen for the retrospective assessment of child maltreatment.
  • [MeSH-major] Adult Survivors of Child Abuse / psychology. Child Abuse / psychology. Child Abuse, Sexual / psychology
  • [MeSH-minor] Adult. Checklist. Child. Dissociative Disorders / psychology. Factor Analysis, Statistical. Female. Germany. Humans. Language. Male. Psychometrics. Reproducibility of Results. Stress Disorders, Post-Traumatic / psychology. Surveys and Questionnaires

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  • [Copyright] © Georg Thieme Verlag KG Stuttgart · New York.
  • (PMID = 20200804.001).
  • [ISSN] 0937-2032
  • [Journal-full-title] Psychotherapie, Psychosomatik, medizinische Psychologie
  • [ISO-abbreviation] Psychother Psychosom Med Psychol
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Validation Studies
  • [Publication-country] Germany
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17. Morris B, Khan R, Ledet D, Howell C, Pui C, Hudson M, Ness K: Neurological morbidity in survivors of childhood acute lymphoblastic leukemia (ALL). J Clin Oncol; 2009 May 20;27(15_suppl):9529

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neurological morbidity in survivors of childhood acute lymphoblastic leukemia (ALL).
  • Because treatment-related neurological morbidity is recognized but poorly characterized, the objective of this cross-sectional study was to estimate the prevalence of neurological symptoms and signs in long-term survivors of childhood ALL.

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  • (PMID = 27964517.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Queudeville M, Eckhoff SM, Debatin K, Meyer LH: Correlatoin of apoptosis signaling in primary pediatric BCP-ALL xenograft cells with the kinetics of engraftment in vivo in a NOD/SCID model and patient outcome. J Clin Oncol; 2009 May 20;27(15_suppl):10043

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Correlatoin of apoptosis signaling in primary pediatric BCP-ALL xenograft cells with the kinetics of engraftment in vivo in a NOD/SCID model and patient outcome.
  • : 10043 Background: We previously identified the importance of intact apoptosis signaling for treatment response in pediatric ALL and AML by analyzing two key apoptogenic events, caspase-3 activation and cytochrome c release.
  • Using a NOD/SCID mouse model for pediatric BCP-ALL we found that short time from transplant to overt leukemia in the recipient mice (short time to leukemia, TTLshort) determines poor patient outcome.
  • METHODS: In this study we investigated the importance of deficient apoptosis signaling for leukemia engraftment in this model.
  • CONCLUSIONS: Our finding in the NOD/SCID/huALL model matches our results in pediatric ALL and AML to conclude that the functional integrity of a downstream apoptotic checkpoint is an important feature regulating leukemia biology.
  • Thus, deficient apoptosis signaling appears to determine rapid engraftment of leukemia cells in the NOD/SCID model in vivo and consequently poor patient outcome.

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  • (PMID = 27962469.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Evans WE, Relling MV: Pharmacogenomics of childhood acute lymphoblastic leukemia (ALL). J Clin Oncol; 2009 May 20;27(15_suppl):s3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pharmacogenomics of childhood acute lymphoblastic leukemia (ALL).
  • : s3 Childhood ALL is a model for drug-responsive cancer: it is successfully cured with medications in 85%-90% of patients, but relapse remains unacceptably high for some subgroups, and therapy is complicated by the occurrence of adverse effects.
  • Based on these studies, candidate gene genotyping has been already incorporated into the treatment of childhood ALL and integrated with electronic medical records at St. Jude to optimize use of a few medications.

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  • (PMID = 27962369.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Abdalla DM, Hamza MA, Kandil AE, Younes LK, Sorrour AF: MYCN gene amplification and DNA ploidy in peripheral neuroblastic tumors. J Clin Oncol; 2009 May 20;27(15_suppl):e22123

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : e22123 Background: Neuroblastoma is a neuroblastic tumor of the primordial crest cells which are precursors of the sympathetic nervous system and is the most common extracranial solid tumor of childhood comprising between 8 and 10% of all childhood cancers.

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  • (PMID = 27963561.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Khattab TM, Jastaniah WA, Felimban SK, Elemam N, Abdullah K, Ahmed B: How could improvement in the management of T-cell acute lymphoblastic leukemia be achieved? Experience of Princess Nourah Oncology Center, National Guard Hospital, Jeddah, Saudi Arabia. J Clin Oncol; 2009 May 20;27(15_suppl):10048

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] How could improvement in the management of T-cell acute lymphoblastic leukemia be achieved? Experience of Princess Nourah Oncology Center, National Guard Hospital, Jeddah, Saudi Arabia.
  • : 10048 Background: T-cell acute lymphoblastic leukemia (T-ALL) is representing 10-15% of pediatric ALL.
  • Our published data showed that T-ALL phenotype patients fared poorly with 5 year survival of 27% versus 83% for precursor B-ALL (Recent Advances Research Update: 2006, 7; 1, P 51-56).
  • OBJECTIVES: We reviewed all patients diagnosed with T-ALL to assess risk classification according to NCI criteria, type of therapy received, overall survival and causes of mortality.
  • METHODS: Retrospective review of all patients files diagnosed with T-ALL from 1989 until now with data collection including; sex, age, white cell count (WBCs), CNS disease, type of protocol used, length of survival, overall survival, cause of death (toxic, disease).

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  • (PMID = 27962474.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Lipshultz SE, Scully RE, Lipsitz SR, Sallan SE, Silverman LB, Miller TL, Orav EJ, Colan SD: Gender differences in long-term dexrazoxane cardioprotection in doxorubicin-treated children with acute lymphoblastic leukemia. J Clin Oncol; 2009 May 20;27(15_suppl):10005

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gender differences in long-term dexrazoxane cardioprotection in doxorubicin-treated children with acute lymphoblastic leukemia.
  • Adding dexrazoxane (DZR) to DOX treatment resulted in reduced myocardial injury in children with acute lymphoblastic leukemia (ALL) during Dana-Farber Cancer Institute Protocol 95-01.
  • METHODS: We centrally remeasured echocardiograms from childhood high-risk ALL survivors in their first continuous remission who were randomly assigned to treatment with DOX only (n = 66; 30 mg/m<sup>2</sup>/dose for 10 doses) or DOX plus DZR 30 minutes prior (n = 68; 300 mg/m<sup>2</sup>/dose).

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  • (PMID = 27962530.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Fauzdar A, Mahajan A, Jain D, Mishra M, Raina V: Amplification of RUNX1 gene in two new cases of childhood B-cell precursor acute lymphoblastic leukemia: A case report. J Clin Oncol; 2009 May 20;27(15_suppl):e21000

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Amplification of RUNX1 gene in two new cases of childhood B-cell precursor acute lymphoblastic leukemia: A case report.
  • : e21000 Background: Chromosome abnormalities of leukemia cells have important prognostic significance in childhood acute lymphoblastic leukemia (ALL).
  • B-cell precursor acute lymphoblastic leukemia (BCP-ALL) ETV6/RUNX1 (alias TEL/AML1) is most frequent i.e.
  • Bone marrow karyotype in combination with molecular cytogenetic techniques like FISH should be done for improvement in sensitivity and accurate cytogenetic analysis in childhood ALL patients for proper identification of prognostic group for optimum treatment.
  • This is one of the few reported studies worldwide for amplification of RUNX1 gene from Indian subcontinent in childhood BCP-ALL.

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  • (PMID = 27960689.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Eichstadt SL, Dahl GV, Fisher PG, Ford JM, Schiffman JD: Correlation of a family history of cancer with risk of relapse and death in pediatric cancer patients. J Clin Oncol; 2009 May 20;27(15_suppl):10029

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Correlation of a family history of cancer with risk of relapse and death in pediatric cancer patients.
  • Such information would be valuable for prognosis, refining treatment protocols, and long-term follow-up in pediatric patients with FHC.
  • METHODS: An historical cohort study of all pediatric patients diagnosed with cancer at Lucile Packard Children's Hospital at Stanford from 1999 - 2002 was performed (n = 363, mean age: 8.4 yrs [0-28 yrs]).
  • RESULTS: 108 (41%) newly diagnosed pediatric patients had reported FHC (1st Degree: n = 14 [5%], 2nd Degree: n = 58 [22%], 3rd Degree: n = 36 [14%]).
  • For patients diagnosed with any pediatric cancer and positive FHC in 1st degree relative, RR of death was significantly elevated (3.74, 95% CI 1.20-11.70).
  • CONCLUSIONS: Pediatric cancer patients with positive FHC among 1st and/or 2nd degree relatives appear to have higher relative risk of relapse compared to those with negative FHC.

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  • (PMID = 27962589.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Mukhopadhyay A, Gupta P, Mukhopadhyay S, Dey S, Basak J, Pandey R: Result of adolescent acute lymphoblastic leukemia protocol (MCP 841) from a developing country. J Clin Oncol; 2009 May 20;27(15_suppl):10046

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Result of adolescent acute lymphoblastic leukemia protocol (MCP 841) from a developing country.
  • : 10046 Background: Acute Lymphatic Leukemia is a curable disease in the range of 80 - 90% in developed countries by aggressive protocol like BFM, St. Judes' but result is much less in adolescence age group (60-70%).
  • As compared to our all pediatric ALL group the outcome is much less and complications are much more.
  • CONCLUSIONS: The data of acute lymphatic leukemia in adolescent is not satisfactory as compared to other pediatric patients.

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  • (PMID = 27962472.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Smith MA, Morton CL, Carol H, Gorlick RG, Kang MH, Keir ST, Kolb EA, Lock RB, Maris JM, Houghton PJ: Pediatric Preclinical Testing Program (PPTP) testing of the CENP-E inhibitor GSK923295A. J Clin Oncol; 2009 May 20;27(15_suppl):10015

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pediatric Preclinical Testing Program (PPTP) testing of the CENP-E inhibitor GSK923295A.
  • METHODS: The PPTP includes a molecularly characterized in vitro panel of cell lines (n = 27) and in vivo panel of xenografts (n = 60) representing most of the common types of childhood solid tumors and childhood acute lymphoblastic leukemia (ALL).

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  • (PMID = 27962529.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Meyer LH, Zangrando A, Eckhoff SM, Queudeville M, Vendramini E, Basso G, Te Kronnie G, Debatin K: Association of time to leukemia (TTL) in NOD/SCID mice with expression of apoptosis regulators in pediatric ALL. J Clin Oncol; 2009 May 20;27(15_suppl):10042

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association of time to leukemia (TTL) in NOD/SCID mice with expression of apoptosis regulators in pediatric ALL.
  • : 10042 Background: Acute lymphoblastic leukemia (ALL) is the most frequent malignant disease in childhood.
  • In a recent study we transplanted pediatric leukemia samples from newly diagnosed BCP-ALL patients into NOD/SCID mice.
  • Time to leukemia (TTL) was analyzed for each patient sample as time from transplant to overt leukemia in the recipients.
  • Patients whose leukemia cells engrafted rapidly showed a clearly inferior relapse free survival in contrast to patient samples with prolonged in vivo growth.
  • METHODS: Gene expression profiles of ALL samples (N = 14) with short versus long TTL in the xenograft model were analyzed using a human whole genome array (Affymetrix U133 Plus 2.0) correlating gene expression values (relative expression) to the time from transplant to manifestation of leukemia in the NOD/SCID mice (TTL, in weeks) by quantitative traits analysis (QTA).
  • Patient samples exhibiting a short time to overt leukemia in the xenotransplant model associated with poor relapse free survival showed down-regulated XAF1 and impaired caspase-3 activation leading to decreased apoptosis of the leukemia cells.
  • CONCLUSIONS: Taken together, we used a novel approach directly correlating gene expression values to time from transplant to overt leukemia (TTL) identifying the apoptosis regulator XAF1 to be associated with poor outcome of patients.
  • Small XIAP-inhibiting molecules can be used to substitute the lacking inhibitory effect of down-regulated XAF1 in these poor responding pediatric ALL patients.

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  • (PMID = 27962468.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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28. Te Loo DM, van Schie RM, Hoogerbrugge PM: Effect of azole antifungal therapy on vincristine toxicity in childhood acute lymphoblastic leukemia. J Clin Oncol; 2009 May 20;27(15_suppl):10049

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of azole antifungal therapy on vincristine toxicity in childhood acute lymphoblastic leukemia.
  • : 10049 Background: Vincristine is one of the corner stitches in the treatment of children with acute lymphoblastic leukemia (ALL).
  • METHODS: In total, twenty pediatric patients with de novo ALL were included in this study.
  • Three patients (15%) treated with azole therapy developed severe toxicity and needed treatment at the pediatric intensive care unit.

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  • (PMID = 27962456.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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29. Grugel L, Streicher B, Lang-Roth R, Walger M, von Wedel H, Meister H: [Development of a German version of the Functioning After Pediatric Cochlear Implantation (FAPCI) questionnaire]. HNO; 2009 Jul;57(7):678-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Development of a German version of the Functioning After Pediatric Cochlear Implantation (FAPCI) questionnaire].
  • [Transliterated title] Entwicklung einer deutschsprachigen Version des Fragebogens Functioning After Pediatric Cochlear Implantation (FAPCI).
  • BACKGROUND: The Functioning After Pediatric Cochlear Implantation (FAPCI) instrument was recently developed to determine the communicative performance of 2-5-year-old prelingually deafened, cochlear-implanted children.
  • [MeSH-minor] Child, Preschool. Humans. Male. Reproducibility of Results. Sensitivity and Specificity. Treatment Outcome

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  • (PMID = 19517081.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Clinical Trial; English Abstract; Journal Article
  • [Publication-country] Germany
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30. Kosseva M, Schild S, Wilhelm-Schwenk R, Biewer W, Häuser W: [Comorbid depression mediates the association of childhood/adolescent maltreatment and fibromyalgia syndrome. A study with patients from different clinical settings]. Schmerz; 2010 Sep;24(5):474-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Comorbid depression mediates the association of childhood/adolescent maltreatment and fibromyalgia syndrome. A study with patients from different clinical settings].
  • [Transliterated title] Komorbide depressive Störungen als Mediator der Assoziation von Misshandlungen in Kindheit/Jugend und Fibromyalgiesyndrom. Eine Fallserie von Patienten aus unterschiedlichen klinischen Kontexten.
  • BACKGROUND: Emotional and physical abuse and neglect in childhood and adolescence [childhood maltreatments (CMs)] are considered to play a role in the etiology of fibromyalgia syndrome (FMS).
  • METHODS: CMs of consecutive FMS patients from three different clinical settings were assessed by the German version of the Childhood Trauma Questionnaire.
  • RESULTS: Of 328 patients (86% women, mean age 50 years), 293 were analyzed; 16% of the patients reported severe emotional, 9% severe physical, and 11% severe sexual abuse and 25% severe emotional and 13% severe physical neglect during childhood.
  • [MeSH-major] Child Abuse / psychology. Child Abuse / statistics & numerical data. Depressive Disorder / epidemiology. Depressive Disorder / psychology. Fibromyalgia / epidemiology. Fibromyalgia / psychology
  • [MeSH-minor] Adult. Child. Child Abuse, Sexual / diagnosis. Child Abuse, Sexual / psychology. Child Abuse, Sexual / statistics & numerical data. Comorbidity. Disability Evaluation. Female. Germany. Humans. Male. Middle Aged. Pain Measurement. Personality Inventory. Risk Factors

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  • (PMID = 20872126.001).
  • [ISSN] 1432-2129
  • [Journal-full-title] Schmerz (Berlin, Germany)
  • [ISO-abbreviation] Schmerz
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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31. Berkes A, Kiss M, Kemény C, Mogyorósy G: [Hungarian validation of the cardiac module of the Pediatric Quality of Life Inventory]. Orv Hetil; 2008 Nov 30;149(48):2261-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Hungarian validation of the cardiac module of the Pediatric Quality of Life Inventory].
  • [Transliterated title] A Pediatric Quality of Life Inventory (PedsQL) gyermekkori életminoség-méro kérdoív kardiológiai moduljának magyarországi validálása.
  • The authors report the validation process of the cardiac module of the Pediatric Quality of Life Inventory (PedsQL ) into Hungarian.
  • OBJECTIVE: To adapt and to test a pediatric quality of life questionnaire for measuring HRQL in children with heart disease.
  • RESULTS: According to the results of the pilot-study the psychic domains have a negative influence on general HRQL index in both child and parent-proxy reports in all age groups.
  • Parent-child concordance is depending on the age of the child, there was expressed difference in the psychosocial domains.
  • [MeSH-minor] Activities of Daily Living. Adolescent. Anxiety / etiology. Child. Child, Preschool. Cognition. Cognition Disorders / etiology. Communication. Female. Health Status. Humans. Hungary. Male. Pediatrics. Pilot Projects. Psychometrics. Severity of Illness Index. Sickness Impact Profile


32. Cribier B, Lieber-Mbomeyo A, Lipsker D: [Clinical and histological study of a case of facial Afro-Caribbean childhood eruption (FACE)]. Ann Dermatol Venereol; 2008 Oct;135(10):663-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical and histological study of a case of facial Afro-Caribbean childhood eruption (FACE)].
  • [Transliterated title] Etude anatomoclinique d'un cas de dermatite périorale granulomateuse de l'enfant (FACE: facial Afro-Caribbean childhood eruption).
  • BACKGROUND: The term Facial Afro-Caribbean childhood eruption (FACE) was coined in 1990 to describe a perioral granulomatous eruption in black-skinned children.
  • Biopsy revealed a diffuse granulomatous infiltrate of the dermis comprising histiocytes, multinucleated giant cells and a heavy lymphocytic component.
  • DISCUSSION: This particular type of perioral dermatitis is seen chiefly in male children with black skin.
  • [MeSH-minor] African Continental Ancestry Group. Child. Humans. Male

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  • (PMID = 18929915.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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33. Hiermann P, Fries M, Hückel D, Kiess W, Merkenschlager A: [Regulatory disorders in infancy: data of the leipzig counseling service for parents with infants and toddlers]. Klin Padiatr; 2005 Mar-Apr;217(2):61-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Regulationsstörungen in der frühen Kindheit: Ergebnisse der Leipziger Beratungsstelle für Eltern mit Säuglingen und Kleinkindern.
  • CONCLUSIONS: The surveyed data support the assumption, that early childhood intervention provides help briefly and economically.
  • [MeSH-major] Child Behavior Disorders / therapy. Child Guidance / methods. Education / methods
  • [MeSH-minor] Child, Preschool. Follow-Up Studies. Humans. Infant. Infant, Newborn. Outcome Assessment (Health Care). Risk Factors. Single-Parent Family

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  • (PMID = 15770575.001).
  • [ISSN] 0300-8630
  • [Journal-full-title] Klinische Pädiatrie
  • [ISO-abbreviation] Klin Padiatr
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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34. Jenneck C, Foelster-Holst R, Hagemann T, Novak N: [Associated diseases and differential diagnostic considerations in childhood atopic eczema]. Hautarzt; 2007 Feb;58(2):163-74; quiz 175-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Associated diseases and differential diagnostic considerations in childhood atopic eczema].
  • [Transliterated title] Differenzialdiagnose des atopischen Ekzems in der Kindheit. Erkrankungen und Syndrome in Assoziation.
  • [MeSH-minor] Child. Child, Preschool. Chronic Disease. Diagnosis, Differential. Humans. Infant

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  • (PMID = 17268788.001).
  • [ISSN] 0017-8470
  • [Journal-full-title] Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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35. Richter-Appelt H, Brinkmann L, Schützmann K: [Parental bonding in childhood and psychological symptoms in a sample of adults with intersexuality]. Psychother Psychosom Med Psychol; 2006 Aug;56(8):325-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Parental bonding in childhood and psychological symptoms in a sample of adults with intersexuality].
  • [Transliterated title] Elterliche Bindung in der Kindheit und psychische Symptombelastung in einer Stichprobe von Erwachsenen mit Intersexualität.
  • [MeSH-minor] Adult. Child. Child Rearing. Data Collection. Female. Humans. Logistic Models. Male. Psychiatric Status Rating Scales. Surveys and Questionnaires

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  • (PMID = 16721707.001).
  • [ISSN] 0937-2032
  • [Journal-full-title] Psychotherapie, Psychosomatik, medizinische Psychologie
  • [ISO-abbreviation] Psychother Psychosom Med Psychol
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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36. Sodtke D, Armbruster MM: [ELTERN-AG--the low threshold school for parents for the early childhood]. Prax Kinderpsychol Kinderpsychiatr; 2007;56(8):707-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [ELTERN-AG--the low threshold school for parents for the early childhood].
  • [Transliterated title] ELTERN-AG-- Die niedrigschwellige Elternschule für die frühe Kindheit.
  • It works with deprived parents from the moment when they plan to get a baby up to their child's school entry.
  • [MeSH-major] Affective Symptoms / prevention & control. Child Abuse / prevention & control. Child Behavior Disorders / prevention & control. Education / methods
  • [MeSH-minor] Adaptation, Psychological. Child. Child, Preschool. Humans. Infant. Object Attachment. Parenting / psychology. Self Efficacy

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  • (PMID = 18051618.001).
  • [ISSN] 0032-7034
  • [Journal-full-title] Praxis der Kinderpsychologie und Kinderpsychiatrie
  • [ISO-abbreviation] Prax Kinderpsychol Kinderpsychiatr
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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37. Hübner B, Hechler T, Dobe M, Damschen U, Kosfelder J, Denecke H, Schroeder S, Zernikow B: [Pain-related disability in adolescents suffering from chronic pain. Preliminary examination of the Pediatric Pain Disability Index (P-PDI)]. Schmerz; 2009 Feb;23(1):20-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pain-related disability in adolescents suffering from chronic pain. Preliminary examination of the Pediatric Pain Disability Index (P-PDI)].
  • [Transliterated title] Schmerzbezogene Beeinträchtigung bei Jugendlichen mit chronischen Schmerzen. Erste Uberprüfung des Pediatric Pain Disability Index (P-PDI).
  • The aim of this study was to translate the Pediatric Pain Disability Index (P-PDI) of Varni into German and to investigate its psychometric qualities.
  • [MeSH-minor] Adolescent. Child. Chronic Disease. Combined Modality Therapy. Cross-Sectional Studies. Female. Follow-Up Studies. Humans. Male. Pain Management. Pain Measurement / statistics & numerical data. Principal Component Analysis. Recurrence

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  • (PMID = 18941801.001).
  • [ISSN] 1432-2129
  • [Journal-full-title] Schmerz (Berlin, Germany)
  • [ISO-abbreviation] Schmerz
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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38. Hardt J, Hoffmann SO: [Childhood in flux--Part II: Modern times until today]. Prax Kinderpsychol Kinderpsychiatr; 2006;55(4):280-92
MedlinePlus Health Information. consumer health - Children's Health.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Childhood in flux--Part II: Modern times until today].
  • [Transliterated title] Kindheit im Wandel--Teil II: Moderne bis heute.
  • Bowlby in the 1950s, it became clear that children of primates need more than air, water and food, namely a relationship between the child and an adult person (attachment).
  • [MeSH-major] Child Abuse / history. Child Care / history. Child Welfare / history. Object Attachment
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Europe. History, 19th Century. History, 20th Century. History, 21st Century. Humans. Infant. United States

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  • (PMID = 17436561.001).
  • [ISSN] 0032-7034
  • [Journal-full-title] Praxis der Kinderpsychologie und Kinderpsychiatrie
  • [ISO-abbreviation] Prax Kinderpsychol Kinderpsychiatr
  • [Language] ger
  • [Publication-type] English Abstract; Historical Article; Journal Article
  • [Publication-country] Germany
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39. Viñas Poch F, Jané Ballabriga MC, Canals Sans J, Esparó Hidalgo G, Ballespí Solà S, Doménech-Llaberia E: [Assessment of psychopathology in preschool age children through the Early Childhood Inventory-4 (ECI-4): agreement among parents and teachers]. Psicothema; 2008 Aug;20(3):481-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Assessment of psychopathology in preschool age children through the Early Childhood Inventory-4 (ECI-4): agreement among parents and teachers].
  • [Transliterated title] Evaluación de la psicopatología del preescolar mediante el Early Childhood Inventory-4 (ECI-4): concordancia entre padres y maestros.
  • The main purpose of this study is to determine the level of agreement among parents and teachers as informants in each one of the dimensions or diagnostic categories of the Early Childhood Inventory-4 (ECI-4).
  • [MeSH-minor] Child. Child, Preschool. Diagnostic and Statistical Manual of Mental Disorders. Female. Humans. Male. Observer Variation. Prevalence

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  • (PMID = 18674447.001).
  • [ISSN] 0214-9915
  • [Journal-full-title] Psicothema
  • [ISO-abbreviation] Psicothema
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] Spain
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40. Gansz B, Ständer S, Metze D: [Acral pseudolymphomatous angiokeratoma of children (APACHE)]. Hautarzt; 2005 Mar;56(3):270-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Akrale pseudolymphomatöse Angiokeratome der Kindheit (APACHE).

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  • (PMID = 15580454.001).
  • [ISSN] 0017-8470
  • [Journal-full-title] Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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41. Lightfoot T: Aetiology of childhood leukemia. Bioelectromagnetics; 2005;Suppl 7:S5-S11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aetiology of childhood leukemia.
  • Leukemia is the most common cancer to affect children, accounting for approximately a third of all childhood cancers.
  • The major morphological subtypes of leukemia, acute lymphoblastic leukemia (ALL), and acute myeloblastic leukemia (AML), are characterized by chromosomal translocations involving over 200 genes including mixed lineage leukemia (MLL), TEL, and AML1.
  • Chromosomal translocations involving the MLL gene at 11q23 are a common feature of infant acute leukemia, found in up to 80% of all cases, and there is strong evidence that rearrangements involving the MLL gene or the TEL-AML1 gene fusion can originate in utero.
  • As with most other cancers, the mechanism by which leukemia arises is likely to involve gene-environment interactions.
  • Exposures acting before birth and early in life has long been thought to be important determinants of leukemia, and the list of suspected chemical, physical, and biological agents continues to increase.
  • Unfortunately, the evidence regarding the majority of suggested exposures is limited and often contradictory, and there are areas, which clearly warrant further investigation in order to further our understanding of the aetiology of childhood leukemia.
  • [MeSH-major] Electromagnetic Fields / adverse effects. Environmental Exposure / adverse effects. Leukemia, Radiation-Induced / etiology. Leukemia, Radiation-Induced / physiopathology. Prenatal Exposure Delayed Effects / etiology. Prenatal Exposure Delayed Effects / physiopathology
  • [MeSH-minor] Child. Child, Preschool. Female. Humans. Infant. Infant, Newborn. Models, Biological. Pregnancy. Risk Assessment / methods. Risk Factors

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc
  • (PMID = 16059922.001).
  • [ISSN] 0197-8462
  • [Journal-full-title] Bioelectromagnetics
  • [ISO-abbreviation] Bioelectromagnetics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 54
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42. Raaschou-Nielsen O: Indoor radon and childhood leukaemia. Radiat Prot Dosimetry; 2008;132(2):175-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Indoor radon and childhood leukaemia.
  • This paper summarises the epidemiological literature on domestic exposure to radon and risk for childhood leukaemia.
  • The results of 12 ecological studies show a consistent pattern of higher incidence and mortality rates for childhood leukaemia in areas with higher average indoor radon concentrations.
  • The seven available case-control studies of childhood leukaemia with measurement of radon concentrations in the residences of cases and controls gave mixed results, however, with some indication of a weak (relative risk < 2) association with acute lymphoblastic leukaemia.
  • The epidemiological evidence to date suggests that an association between indoor exposure to radon and childhood leukaemia might exist, but is weak.
  • [MeSH-major] Air Pollution, Indoor / analysis. Air Pollution, Indoor / statistics & numerical data. Air Pollution, Radioactive / analysis. Air Pollution, Radioactive / statistics & numerical data. Environmental Exposure / statistics & numerical data. Leukemia, Radiation-Induced / epidemiology. Radon / analysis
  • [MeSH-minor] Body Burden. Child. Humans. Incidence. Radiation Monitoring / statistics & numerical data. Risk Assessment / methods. Risk Factors

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  • (PMID = 19010936.001).
  • [ISSN] 0144-8420
  • [Journal-full-title] Radiation protection dosimetry
  • [ISO-abbreviation] Radiat Prot Dosimetry
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis; Review
  • [Publication-country] England
  • [Chemical-registry-number] Q74S4N8N1G / Radon
  • [Number-of-references] 25
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43. Jamroziak K, Robak T: Do polymorphisms in ABC transporter genes influence risk of childhood acute lymphoblastic leukemia? Leuk Res; 2008 Aug;32(8):1173-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Do polymorphisms in ABC transporter genes influence risk of childhood acute lymphoblastic leukemia?
  • It is widely accepted that pathogenesis of childhood acute lymphoblastic leukemia (ALL) is related to the interplay between specific environmental exposure and inherited background.
  • Here, we review several recent reports on potential association between single nucleotide polymorphisms (SNPs) in genes encoding for ABC transporters with predisposition to pediatric ALL.
  • [MeSH-major] ATP-Binding Cassette Transporters / genetics. Polymorphism, Single Nucleotide. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • [MeSH-minor] Child. Child, Preschool. Genetic Predisposition to Disease. Humans. P-Glycoprotein / genetics

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  • [CommentOn] Leuk Res. 2008 Aug;32(8):1214-20 [18243305.001]
  • (PMID = 18294687.001).
  • [ISSN] 0145-2126
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Comment; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / P-Glycoprotein
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44. Dunwell TL, Hesson LB, Pavlova T, Zabarovska V, Kashuba V, Catchpoole D, Chiaramonte R, Brini AT, Griffiths M, Maher ER, Zabarovsky E, Latif F: Epigenetic analysis of childhood acute lymphoblastic leukemia. Epigenetics; 2009 Apr 1;4(3):185-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epigenetic analysis of childhood acute lymphoblastic leukemia.
  • We used a chromosome 3 wide NotI microarray for identification of epigenetically inactivated genes in childhood acute lymphoblastic leukemia (ALL).
  • Three novel genes demonstrated frequent methylation in childhood ALL.
  • In our series of childhood ALL BNC1 was frequently methylated in both T (77%) and B-ALL (79%), whilst MSX1 showed T-ALL (25%) specific methylation.
  • The methylation of the above five genes was cancer specific and expression of the genes could be restored in methylated leukemia cell lines treated with 5-aza-2'-deoxycytidine.
  • This is the first report demonstrating frequent epigenetic inactivation of PPP2R3A, FBLN2, THRB, BNC1 and MSX1 in leukemia.
  • [MeSH-major] Chromosomes, Human, Pair 3 / genetics. DNA Methylation. Epigenesis, Genetic. Gene Expression Regulation, Leukemic. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics


45. Nathan PC, Wasilewski-Masker K, Janzen LA: Long-term outcomes in survivors of childhood acute lymphoblastic leukemia. Hematol Oncol Clin North Am; 2009 Oct;23(5):1065-82, vi-vii
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term outcomes in survivors of childhood acute lymphoblastic leukemia.
  • Cure rates for childhood acute lymphoblastic leukemia (ALL) now exceed 80%.
  • Consequently, there is a growing population of survivors of childhood ALL who are at risk for developing late sequelae of their cancer therapy.
  • In this article, the more common, serious late effects of ALL therapy are reviewed, the treatment exposures that predispose some survivors to their development are discussed, and the need for life-long risk-based medical care for all survivors of childhood ALL is emphasized.
  • [MeSH-major] Precursor Cell Lymphoblastic Leukemia-Lymphoma / mortality. Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
  • [MeSH-minor] Child. Humans. Survivors. Time Factors. Treatment Outcome


46. Işik N, Balak N, Silav G, Elmaci I: Pediatric intramedullary teratomas. Neuropediatrics; 2008 Aug;39(4):196-9
MedlinePlus Health Information. consumer health - Children's Health.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pediatric intramedullary teratomas.
  • Teratomas account for 3% of all childhood tumors, with the majority occurring in the sacrococcygeal region and in the ovary.
  • [MeSH-minor] Child, Preschool. Female. Humans. Magnetic Resonance Imaging

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  • (PMID = 19165706.001).
  • [ISSN] 0174-304X
  • [Journal-full-title] Neuropediatrics
  • [ISO-abbreviation] Neuropediatrics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 37
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47. Hegedus CM, Gunn L, Skibola CF, Zhang L, Shiao R, Fu S, Dalmasso EA, Metayer C, Dahl GV, Buffler PA, Smith MT: Proteomic analysis of childhood leukemia. Leukemia; 2005 Oct;19(10):1713-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Proteomic analysis of childhood leukemia.
  • Childhood acute lymphoblastic and myeloid leukemias are stratified into molecular and cytogenetic subgroups important for prognosis and therapy.
  • Studies have shown that gene expression profiles can discriminate between leukemia subtypes.
  • Thus, proteome analysis similarly holds the potential for characterizing different subtypes of childhood leukemia.
  • We used surface-enhanced laser desorption/ionization time-of-flight mass spectrometry to analyze cell lysates from childhood leukemia cell lines as well as pretreatment leukemic bone marrow derived from childhood leukemia cases.
  • Comparison of the acute myeloid leukemia (AML) cell line, Kasumi, and the biphenotypic myelomonocytic cell line, MV4;11, with the acute lymphoblastic leukemia (ALL) cell lines, 697 and REH, revealed many differentially expressed proteins.
  • Analysis of childhood leukemia bone marrow showed differentially expressed proteins between AML and ALL, including a similar peak at 8.3 kDa, as well as several proteins that differentiate between the ALL t(12;21) and hyperdiploid subtypes.
  • These results demonstrate the potential for proteome analysis to distinguish between various forms of childhood leukemia.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Leukemia, Myeloid / metabolism. Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism. Proteomics
  • [MeSH-minor] Acute Disease. Adolescent. Bone Marrow Cells / metabolism. Bone Marrow Cells / pathology. Child. Humans. Peptide Mapping. Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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  • (PMID = 16136170.001).
  • [ISSN] 0887-6924
  • [Journal-full-title] Leukemia
  • [ISO-abbreviation] Leukemia
  • [Language] eng
  • [Grant] United States / NIEHS NIH HHS / ES / P42 ES004705; United States / NIEHS NIH HHS / ES / P30 ES01896; United States / NIEHS NIH HHS / ES / P42ES04705; United States / NIEHS NIH HHS / ES / R01 ES09137
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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48. Sinnett D, Labuda D, Krajinovic M: Challenges identifying genetic determinants of pediatric cancers--the childhood leukemia experience. Fam Cancer; 2006;5(1):35-47
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Challenges identifying genetic determinants of pediatric cancers--the childhood leukemia experience.
  • Pediatric cancers affect approximately 1 in every 500 children before the age of 15.
  • Because of its relatively high prevalence, most of the work done in pediatric oncogenetics has been focused on leukemias, particularly acute lymphoblastic leukemia (ALL).
  • Although it is now well accepted that genetic variation plays a significant role in determining individual's cancer susceptibility, few studies have explored genetic susceptibility to childhood leukemia with respect to common polymorphisms.
  • To evaluate whether candidate genes in these pathways are involved in childhood leukemogenesis, we conducted case-control studies.
  • We also observed that, at least at some loci, the parental genetics might be important in predicting the risk of cancer in this pediatric model of a complex disease.
  • Taken together, these results indicate that the investigation of a single enzyme and/or a single genotype might not be sufficient to explain the etiology of childhood leukemia because of the complexity of the environment and that of the inter-individual variability in cancer susceptibility.
  • [MeSH-major] Cytochrome P-450 Enzyme System / genetics. Genetic Predisposition to Disease / epidemiology. Glutathione Transferase / genetics. Oxidative Stress / physiology. Polymorphism, Genetic. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • [MeSH-minor] Child. Child, Preschool. Confidence Intervals. Female. Gene Expression Regulation, Neoplastic. Genotype. Humans. Incidence. Male. Odds Ratio. Pediatrics. Pedigree. Prognosis. Risk Assessment

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  • (PMID = 16528607.001).
  • [ISSN] 1389-9600
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 9035-51-2 / Cytochrome P-450 Enzyme System; EC 2.5.1.18 / Glutathione Transferase
  • [Number-of-references] 136
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49. Sinnett D, N'Diaye N, Labuda D, Krajinovic M: [Genetic determinants of childhood leukemia]. Bull Cancer; 2006 Sep;93(9):857-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Genetic determinants of childhood leukemia].
  • [Transliterated title] Les déterminants génétiques de la leucémie de l'enfant.
  • Pediatric cancers affect approximately 1 in every 500 children before the age of 15.
  • Because of its relatively high prevalence, most of the work done in pediatric oncogenetics has been focused on leukemias, particularly acute lymphoblastic leukemia (ALL).
  • Although it is now well accepted that genetic variations play a significant role in determining individual's cancer susceptibility, few studies have explored genetic susceptibility to childhood leukemia with respect to common polymorphisms.
  • To evaluate whether candidate genes in these pathways are involved in childhood leukemogenesis, we conducted association studies.
  • We also observed that, at least at some loci, the parental genetics might be important in predicting the risk of cancer in this pediatric model of a complex disease.
  • Taken together, these results indicate that the investigation of a single enzyme and/or a single genotype might not be sufficient to explain the etiology of childhood leukemia because of the complexity of the environment and that of the inter-individual variability in cancer susceptibility.
  • [MeSH-major] Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • [MeSH-minor] Adolescent. Carcinogens / metabolism. Child. Cytochrome P-450 Enzyme System / genetics. Cytochrome P-450 Enzyme System / metabolism. Environment. Female. Folic Acid / metabolism. Genetic Predisposition to Disease. Glutathione Transferase / genetics. Glutathione Transferase / metabolism. Humans. Male. Maternal Exposure / adverse effects. Oxidative Stress. Paternal Exposure / adverse effects

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  • (PMID = 16980228.001).
  • [ISSN] 1769-6917
  • [Journal-full-title] Bulletin du cancer
  • [ISO-abbreviation] Bull Cancer
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Carcinogens; 9035-51-2 / Cytochrome P-450 Enzyme System; 935E97BOY8 / Folic Acid; EC 2.5.1.18 / Glutathione Transferase
  • [Number-of-references] 65
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50. Whitley E, Gunnell D, Davey Smith G, Holly JM, Martin RM: Childhood circumstances and anthropometry: the Boyd Orr cohort. Ann Hum Biol; 2008 Sep-Oct;35(5):518-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Childhood circumstances and anthropometry: the Boyd Orr cohort.
  • BACKGROUND: Childhood environment is known to affect stature in childhood and adulthood.
  • Peak growth for different anthropometric measures occurs at different times and so associations with childhood conditions that vary across different components of stature may indicate periods of growth that are particularly influenced by environmental factors.
  • METHODS: The study examined relationships between anthropometric measurements (foot length, shoulder breadth, height, trunk and leg length) and childhood exposures (breast-feeding, birth order, household income, household food expenditure, social class, crowding, number of children in the household, and household diet) in 2376 members of the Boyd Orr cohort aged 2-14 years.
  • RESULTS: All childhood exposures were associated with childhood anthropometric measures to some degree.
  • CONCLUSIONS: The individual components of stature most strongly associated with childhood environment in this age group were leg and foot length.
  • [MeSH-minor] Adolescent. Age Distribution. Child. Child, Preschool. Cohort Studies. Confidence Intervals. Female. Health Surveys. Humans. Male. Sex Characteristics

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  • (PMID = 18821329.001).
  • [ISSN] 1464-5033
  • [Journal-full-title] Annals of human biology
  • [ISO-abbreviation] Ann. Hum. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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51. Yang YL, Lin SR, Chen JS, Lin SW, Yu SL, Chen HY, Yen CT, Lin CY, Lin JF, Lin KH, Jou ST, Hu CY, Chang SK, Lu MY, Chang HH, Chang WH, Lin KS, Lin DT: Expression and prognostic significance of the apoptotic genes BCL2L13, Livin, and CASP8AP2 in childhood acute lymphoblastic leukemia. Leuk Res; 2010 Jan;34(1):18-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression and prognostic significance of the apoptotic genes BCL2L13, Livin, and CASP8AP2 in childhood acute lymphoblastic leukemia.
  • Improved treatment of childhood acute lymphoblastic leukemia (ALL) depends on the identification of new molecular markers that are able to predict treatment response and clinical outcome.
  • We investigated the expression of three apoptosis related genes, BCL2L13, CASP8AP2, and Livin, as well as their prognostic significance, in a retrospective study of 90 pediatric ALL patients diagnosed between 1996 and 2007 in Taiwan.
  • Multivariate analysis for EFS and OS demonstrated that high expression of BCL2L13 was an independent prognostic factor for childhood ALL in this ethnic group.
  • [MeSH-major] Adaptor Proteins, Signal Transducing / genetics. Apoptosis / genetics. Apoptosis Regulatory Proteins / genetics. Calcium-Binding Proteins / genetics. Inhibitor of Apoptosis Proteins / genetics. Neoplasm Proteins / genetics. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics. Proto-Oncogene Proteins c-bcl-2 / genetics
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Humans. Infant. Infant, Newborn. Male. Prognosis. Proportional Hazards Models. Reverse Transcriptase Polymerase Chain Reaction

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  • [Copyright] 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 20109966.001).
  • [ISSN] 1873-5835
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Apoptosis Regulatory Proteins; 0 / BCL2L13 protein, human; 0 / BIRC7 protein, human; 0 / CASP8AP2 protein, human; 0 / Calcium-Binding Proteins; 0 / Inhibitor of Apoptosis Proteins; 0 / Neoplasm Proteins; 0 / Proto-Oncogene Proteins c-bcl-2
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52. Udayakumar AM, Bashir WA, Pathare AV, Wali YA, Zacharia M, Khan AA, Soliman H, Al-Lamki Z, Raeburn JA: Cytogenetic profile of childhood acute lymphoblastic leukemia in Oman. Arch Med Res; 2007 Apr;38(3):305-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytogenetic profile of childhood acute lymphoblastic leukemia in Oman.
  • BACKGROUND: Chromosomal abnormalities have important diagnostic and prognostic significance in acute lymphoblastic leukemia (ALL).
  • The purpose of this study was to define and classify the frequency and type of chromosomal abnormalities among newly diagnosed children with ALL and compare the results with those reported from other geographical regions of the world.
  • METHODS: Bone marrow chromosomal studies with GTG banding were performed in untreated ALL pediatric patients aged from 7 days to 14 years.
  • To our knowledge, this is the first report from the Middle East of a cytogenetic study on childhood ALL.
  • [MeSH-major] Chromosome Aberrations. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Cytogenetics. Female. Humans. Immunophenotyping. Infant. Infant, Newborn. Male. Oman. Ploidies

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  • (PMID = 17350480.001).
  • [ISSN] 0188-4409
  • [Journal-full-title] Archives of medical research
  • [ISO-abbreviation] Arch. Med. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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53. Emerenciano M, Koifman S, Pombo-de-Oliveira MS: Acute leukemia in early childhood. Braz J Med Biol Res; 2007 Jun;40(6):749-60

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acute leukemia in early childhood.
  • Acute leukemia in early childhood is biologically and clinically distinct.
  • The pro-B, CD10 negative immunophenotype is typically found in infant acute leukemia, and the most common genetic alterations are the rearrangements of the MLL gene.
  • The Brazilian Collaborative Study Group of Infant Acute Leukemia has found that mothers exposed to dipyrone, pesticides and hormones had an increased chance to give birth to babies with infant acute leukemia [OR = 1.48 (95%CI = 1.05-2.07), OR = 2.27 (95%CI = 1.56-3.31) and OR = 9.08 (95%CI = 2.95-27.96)], respectively.
  • This review aims to summarize recent clues that have facilitated the elucidation of the biology of early childhood leukemias, with emphasis on infant acute leukemia in the Brazilian population.

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  • (PMID = 17581672.001).
  • [ISSN] 0100-879X
  • [Journal-full-title] Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • [ISO-abbreviation] Braz. J. Med. Biol. Res.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / MLL protein, human; 149025-06-9 / Myeloid-Lymphoid Leukemia Protein; EC 2.1.1.43 / Histone-Lysine N-Methyltransferase
  • [Number-of-references] 60
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54. Kulkarni KP, Marwaha RK: Pattern and implications of therapy abandonment in childhood acute lymphoblastic leukemia. Asian Pac J Cancer Prev; 2010;11(5):1435-6
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  • [Title] Pattern and implications of therapy abandonment in childhood acute lymphoblastic leukemia.
  • In this communication we describe the pattern of therapy abandonment and its impact on survival of childhood acute lymphoblastic leukemia at a large tertiary care center in Northern India and discuss remedial measures.
  • [MeSH-major] Medication Therapy Management. Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy. Treatment Refusal. Withholding Treatment

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  • (PMID = 21198307.001).
  • [ISSN] 2476-762X
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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55. Settin A, Al Haggar M, Al Dosoky T, Al Baz R, Abdelrazik N, Fouda M, Aref S, Al-Tonbary Y: Prognostic cytogenetic markers in childhood acute lymphoblastic leukemia. Indian J Pediatr; 2007 Mar;74(3):255-63
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  • [Title] Prognostic cytogenetic markers in childhood acute lymphoblastic leukemia.
  • OBJECTIVE: To evaluate children with acute lymphoblastic leukemia (ALL) showing resistance to immediate induction chemotherapy in relation to conventional and advanced cytogenetic analysis.
  • CONCLUSION: Some cytogenetic and molecular characterizations of childhood ALL could add prognostic criteria for proper therapy allocation.
  • [MeSH-major] Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Cytogenetic Analysis. Female. Humans. Infant. Male. Prognosis

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  • (PMID = 17401264.001).
  • [ISSN] 0973-7693
  • [Journal-full-title] Indian journal of pediatrics
  • [ISO-abbreviation] Indian J Pediatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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56. Novara F, Beri S, Bernardo ME, Bellazzi R, Malovini A, Ciccone R, Cometa AM, Locatelli F, Giorda R, Zuffardi O: Different molecular mechanisms causing 9p21 deletions in acute lymphoblastic leukemia of childhood. Hum Genet; 2009 Oct;126(4):511-20
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  • [Title] Different molecular mechanisms causing 9p21 deletions in acute lymphoblastic leukemia of childhood.
  • Deletion of chromosome 9p21 is a crucial event for the development of several cancers including acute lymphoblastic leukemia (ALL).
  • We have cloned 23 breakpoint junctions for a total of 46 breakpoints in 17 childhood ALL (9 B- and 8 T-lineages) showing different size deletions at one or both homologous chromosomes 9 to investigate which particular sequences make the region susceptible to interstitial deletion.
  • [MeSH-major] Chromosomes, Human, Pair 9 / genetics. Cyclin-Dependent Kinase Inhibitor p15 / genetics. Cyclin-Dependent Kinase Inhibitor p16 / genetics. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics. Sequence Deletion / genetics
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Chromosome Breakage. Comparative Genomic Hybridization. CpG Islands. DNA Methylation. DNA Primers. Female. Heterozygote. Humans. Infant. Male. Oligonucleotide Array Sequence Analysis. Promoter Regions, Genetic / genetics

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  • (PMID = 19484265.001).
  • [ISSN] 1432-1203
  • [Journal-full-title] Human genetics
  • [ISO-abbreviation] Hum. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CDKN2B protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p15; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA Primers
  • [Other-IDs] NLM/ PMC2762534
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57. Ramchandren S, Leonard M, Mody RJ, Donohue JE, Moyer J, Hutchinson R, Gurney JG: Peripheral neuropathy in survivors of childhood acute lymphoblastic leukemia. J Peripher Nerv Syst; 2009 Sep;14(3):184-9
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  • [Title] Peripheral neuropathy in survivors of childhood acute lymphoblastic leukemia.
  • Acute lymphoblastic leukemia (ALL) is the most common form of cancer in children.
  • Thirty-seven survivors of childhood ALL aged 8-18 underwent evaluation for neuropathy through self-reported symptoms, standardized examinations, and nerve conduction studies (NCS).

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  • (PMID = 19909482.001).
  • [ISSN] 1529-8027
  • [Journal-full-title] Journal of the peripheral nervous system : JPNS
  • [ISO-abbreviation] J. Peripher. Nerv. Syst.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / K23 NS072279; United States / NINDS NIH HHS / NS / T32 NS07222-23; United States / NINDS NIH HHS / NS / T32 NS007222; United States / NHLBI NIH HHS / HL / K03 HL04108; United States / NHLBI NIH HHS / HL / K30 HL004108
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 5J49Q6B70F / Vincristine
  • [Other-IDs] NLM/ NIHMS529407; NLM/ PMC3865985
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58. Meeker ND, Yang JJ, Schiffman JD: Pharmacogenomics of pediatric acute lymphoblastic leukemia. Expert Opin Pharmacother; 2010 Jul;11(10):1621-32
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  • [Title] Pharmacogenomics of pediatric acute lymphoblastic leukemia.
  • IMPORTANCE OF THE FIELD: Pediatric acute lymphoblastic leukemia (ALL) represents one of the best examples of progress in disease treatment and improved outcome based in part upon the incorporation of the principles of pharmacogenomics.
  • Throughout the past several decades, clinical scientists have continued to refine risk stratification in clinical trials with the understanding that individual patients have different subtypes of pediatric ALL that will respond to therapy in different, but predictable ways.
  • AREAS COVERED IN THIS REVIEW: Discussed in this review are the most significant findings from pharmacogenomic studies of pediatric ALL from 1989 to the present.
  • Pharmacogenomic studies related to the drugs commonly used to treat pediatric ALL are covered in detail, including an emphasis on both genome-wide and candidate gene/pathway approaches.
  • TAKE HOME MESSAGE: The outcome for children with pediatric ALL has improved greatly, and this is in part due to the successful integration of data from pharmacogenomic studies into clinical trials.
  • [MeSH-major] Pharmacogenetics. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • [MeSH-minor] Child. Cytochrome P-450 CYP3A / genetics. Glucocorticoids / therapeutic use. Humans. Methotrexate / therapeutic use. Methyltransferases / genetics. Neoplasm, Residual. Vincristine / therapeutic use

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  • (PMID = 20429672.001).
  • [ISSN] 1744-7666
  • [Journal-full-title] Expert opinion on pharmacotherapy
  • [ISO-abbreviation] Expert Opin Pharmacother
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Glucocorticoids; 5J49Q6B70F / Vincristine; EC 1.14.14.1 / CYP3A5 protein, human; EC 1.14.14.1 / Cytochrome P-450 CYP3A; EC 2.1.1.- / Methyltransferases; EC 2.1.1.67 / thiopurine methyltransferase; YL5FZ2Y5U1 / Methotrexate
  • [Number-of-references] 120
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59. Liu Y, Chen J, Tang J, Ni S, Xue H, Pan C: Cost of childhood acute lymphoblastic leukemia care in Shanghai, China. Pediatr Blood Cancer; 2009 Oct;53(4):557-62
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  • [Title] Cost of childhood acute lymphoblastic leukemia care in Shanghai, China.
  • BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most common and curable malignant pediatric disease in children.
  • Here, we analyzed the overall costs for pediatric ALL therapies and their constitutive elements.
  • Forty cases were B-lineage, four were T-lineage, and one was double-lymphoid lineage.
  • Average overall costs for childhood ALL in this study were less than US $11,000, with reasonable clinical results.
  • [MeSH-major] Health Care Costs. Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
  • [MeSH-minor] Adolescent. Child. Child, Preschool. China. Female. Humans. Infant. Male

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  • (PMID = 19526524.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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60. Robinson KE, Livesay KL, Campbell LK, Scaduto M, Cannistraci CJ, Anderson AW, Whitlock JA, Compas BE: Working memory in survivors of childhood acute lymphocytic leukemia: functional neuroimaging analyses. Pediatr Blood Cancer; 2010 Apr;54(4):585-90
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  • [Title] Working memory in survivors of childhood acute lymphocytic leukemia: functional neuroimaging analyses.
  • BACKGROUND: Research on the physical and psychological late effects of treatment of childhood cancer has led to the identification of significant long-term neurocognitive deficits experienced by some survivors, particularly in the areas of memory and executive functioning.
  • PROCEDURE: This study used functional neuroimaging techniques to examine working memory and executive functioning deficits of survivors of childhood acute lymphocytic leukemia (ALL), as compared to age- and gender-matched healthy controls.
  • CONCLUSIONS: These results support the theory of compensatory activation in necessary brain regions in order to complete tasks in pediatric ALL survivors, similar to that observed in multiple sclerosis patients.

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  • (PMID = 19953649.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA068485-13S4; United States / NCI NIH HHS / CA / P30 CA068485; United States / NCI NIH HHS / CA / CA068485; United States / NCI NIH HHS / CA / P30 CA068485-13S4
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 04079A1RDZ / Cytarabine; YL5FZ2Y5U1 / Methotrexate
  • [Other-IDs] NLM/ NIHMS183910; NLM/ PMC2901833
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61. O'Connor SM, Boneva RS: Infectious etiologies of childhood leukemia: plausibility and challenges to proof. Environ Health Perspect; 2007 Jan;115(1):146-50
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  • [Title] Infectious etiologies of childhood leukemia: plausibility and challenges to proof.
  • Infections as well as environmental exposures are proposed determinants of childhood acute lymphoblastic leukemia (ALL), particularly common precursor B-cell ALL (cALL).
  • Lines of investigation test hypotheses that cALL is a rarer result of common infection, that it results from uncommon infection, or that it ensues from abnormal immune development; perhaps it requires a preceding prenatal or early childhood insult.
  • Ideally, studies should document that particular infections precede leukemiA and induce malignant transformation.
  • Primarily based on surrogate markers of infectious exposure, indirect evidence from ecologic and epidemiologic studies varies widely, but some suggest that infancy or early childhood infectious exposures might protect against childhood ALL or cALL.
  • Other challenges to proof include the likely time lag between infection and diagnosis, the ubiquity of many infections, the influence of age at infection, and the limitations in laboratory assays; small numbers of cases, inaccurate background leukemia rates, and difficulty tracking mobile populations further affect duster investigations.
  • [MeSH-major] Communicable Diseases / complications. Precursor Cell Lymphoblastic Leukemia-Lymphoma / etiology
  • [MeSH-minor] Child. Humans

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  • (PMID = 17366835.001).
  • [ISSN] 0091-6765
  • [Journal-full-title] Environmental health perspectives
  • [ISO-abbreviation] Environ. Health Perspect.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 86
  • [Other-IDs] NLM/ PMC1817664
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62. Hasanbegovic E, Mehadzic S: [Etiology of lymphadenopathy in childhood]. Med Glas (Zenica); 2010 Aug;7(2):132-6
MedlinePlus Health Information. consumer health - Lymphatic Diseases.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Etiology of lymphadenopathy in childhood].
  • METHODS: One hundred and fifteen children aged 0-15 years with diagnosed lymphadenopathy at the Pediatric Clinic in Sarajevo during 2008 were included in the study.
  • Most frequent causes of malignant lymphadenopathy were acute lymphoblastic leukemia in 11 children (55 %) and acute myeloid leukemia in two (10%) children.
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Humans. Infant. Male

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  • (PMID = 21258308.001).
  • [ISSN] 1840-0132
  • [Journal-full-title] Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina
  • [ISO-abbreviation] Med Glas (Zenica)
  • [Language] bos
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Bosnia and Herzegovina
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63. Chang JS, Wiemels JL, Chokkalingam AP, Metayer C, Barcellos LF, Hansen HM, Aldrich MC, Guha N, Urayama KY, Scélo G, Green J, May SL, Kiley VA, Wiencke JK, Buffler PA: Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia. Cancer Epidemiol Biomarkers Prev; 2010 Sep;19(9):2152-63
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia.
  • BACKGROUND: Childhood acute lymphoblastic leukemia (ALL) has been hypothesized to have an infection- and immune-related etiology.
  • The lack of immune priming in early childhood may result in abnormal immune responses to infections later in life and increase ALL risk.
  • METHODS: The current analyses examined the association between childhood ALL and 208 single-nucleotide polymorphisms (SNP) of 29 adaptive immune function genes among 377 ALL cases and 448 healthy controls.
  • This increased risk was stronger among firstborn children of all ethnicities and among non-Hispanic children with less day care attendance, consistent with the hypothesis about the role of early immune modulation in the development of childhood ALL.
  • Haplotype analyses identified additional regions of CD28, FCGR2, GATA3, IL2RA, STAT4, and STAT6 associated with childhood ALL.
  • CONCLUSION: Polymorphisms of genes on the adaptive immunity pathway are associated with childhood ALL risk.
  • IMPACT: Results of this study support an immune-related etiology of childhood ALL.

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  • [Copyright] (c) 2010 AACR.
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  • (PMID = 20716621.001).
  • [ISSN] 1538-7755
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / R01 ES009137-08; United States / NIEHS NIH HHS / ES / ES009137-10; United States / NIEHS NIH HHS / ES / P42 ES004705-22S10023; United States / NIEHS NIH HHS / ES / R01 ES009137-01A1; United States / NIEHS NIH HHS / ES / P42 ES004705-22S20023; United States / NIEHS NIH HHS / ES / ES009137-05S1; United States / NIEHS NIH HHS / ES / P42 ES004705-200023; United States / NIEHS NIH HHS / ES / P42 ES004705-220023; United States / NIEHS NIH HHS / ES / ES009137-02; United States / NIEHS NIH HHS / ES / ES009137-05; United States / NIEHS NIH HHS / ES / ES009137-04; United States / NIEHS NIH HHS / ES / ES009137-01A1; United States / NIEHS NIH HHS / ES / R01 ES009137-02; United States / NIEHS NIH HHS / ES / R01 ES009137-03; United States / NIEHS NIH HHS / ES / P42 ES004705; United States / NCI NIH HHS / CA / R25 CA112355; United States / NIEHS NIH HHS / ES / ES004705-22S30023; United States / NIEHS NIH HHS / ES / R01 ES009137-10S1; United States / NIEHS NIH HHS / ES / ES009137-03S1; United States / NIEHS NIH HHS / ES / R01 ES009137-07; United States / NIEHS NIH HHS / ES / ES004705-190023; United States / NIEHS NIH HHS / ES / ES004705-200023; United States / NIEHS NIH HHS / ES / R01 ES009137-05S1; United States / NIEHS NIH HHS / ES / R01 ES009137-10; United States / NIEHS NIH HHS / ES / ES004705-230023; United States / NIEHS NIH HHS / ES / PS42ES04705; United States / NIEHS NIH HHS / ES / ES004705-210023; United States / NIEHS NIH HHS / ES / ES009137-06A1; United States / NIEHS NIH HHS / ES / P42 ES004705-22S30023; United States / NIEHS NIH HHS / ES / P42 ES004705-210023; United States / NIEHS NIH HHS / ES / R01 ES009137-03S1; United States / NIEHS NIH HHS / ES / P42 ES004705-230023; United States / NIEHS NIH HHS / ES / ES009137-07; United States / NIEHS NIH HHS / ES / R01 ES009137-04; United States / NIEHS NIH HHS / ES / ES009137-09; United States / NIEHS NIH HHS / ES / ES004705-220023; United States / NIEHS NIH HHS / ES / R01ES09137; United States / NIEHS NIH HHS / ES / ES004705-22S10023; United States / NIEHS NIH HHS / ES / R01 ES009137-06A1; United States / NIEHS NIH HHS / ES / ES004705-22S20023; United States / NIEHS NIH HHS / ES / R01 ES009137; United States / NIEHS NIH HHS / ES / ES009137-10S1; United States / NIEHS NIH HHS / ES / R01 ES009137-05; United States / NIEHS NIH HHS / ES / ES009137-03; United States / NIEHS NIH HHS / ES / P42 ES004705-190023; United States / NIEHS NIH HHS / ES / R01 ES009137-09
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS220398; NLM/ PMC3257312
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64. Campbell LK, Scaduto M, Van Slyke D, Niarhos F, Whitlock JA, Compas BE: Executive function, coping, and behavior in survivors of childhood acute lymphocytic leukemia. J Pediatr Psychol; 2009 Apr;34(3):317-27
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Executive function, coping, and behavior in survivors of childhood acute lymphocytic leukemia.
  • OBJECTIVE: To examine the role of executive function in coping and behavioral outcomes in childhood acute lymphocytic leukemia (ALL) survivors.
  • Directions for future research on executive function deficits and coping skills in survivors of pediatric ALL are suggested.
  • [MeSH-major] Adaptation, Psychological. Cognition. Emotions. Precursor Cell Lymphoblastic Leukemia-Lymphoma / psychology. Stress, Psychological / etiology. Survivors / psychology
  • [MeSH-minor] Adolescent. Case-Control Studies. Child. Female. Humans. Male. Neuropsychological Tests / statistics & numerical data. Young Adult

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  • (PMID = 18667478.001).
  • [ISSN] 1465-735X
  • [Journal-full-title] Journal of pediatric psychology
  • [ISO-abbreviation] J Pediatr Psychol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2722127
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65. Liu Y: [Prognosis prediction for childhood acute lymphoblastic leukemia--review]. Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2007 Feb;15(1):202-6
Genetic Alliance. consumer health - Acute Lymphoblastic Leukemia, Childhood.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Prognosis prediction for childhood acute lymphoblastic leukemia--review].
  • Contemporary risk-directed therapy has advanced the cure rate for childhood acute lymphoblastic leukemia to near 80%.
  • The risk factors and systems of assessment in prognosis prediction for childhood acute lymphoblastic leukemia were summarised in this review.

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  • (PMID = 17490555.001).
  • [ISSN] 1009-2137
  • [Journal-full-title] Zhongguo shi yan xue ye xue za zhi
  • [ISO-abbreviation] Zhongguo Shi Yan Xue Ye Xue Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 22
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66. Kuhn A, Hanneken S, Megahed M, Ruzicka T, Neumann NJ: [Extreme photosensitivity since childhood]. Hautarzt; 2006 Jan;57(1):56-8, 60

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Extreme photosensitivity since childhood].
  • [Transliterated title] Extreme Photosensitivität seit der Kindheit.

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  • (PMID = 16440239.001).
  • [ISSN] 0017-8470
  • [Journal-full-title] Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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67. Watanabe A: [Recent advance in treatment of childhood acute lymphoblastic leukemia]. Gan To Kagaku Ryoho; 2007 Feb;34(2):150-5
Genetic Alliance. consumer health - Acute Lymphoblastic Leukemia, Childhood.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Recent advance in treatment of childhood acute lymphoblastic leukemia].
  • The five-year event-free survival of nearly 80% in childhood acute lymphoblastic leukemia (ALL) achieved in the 1990 s attested to the effectiveness of risk-directed therapy developed through well-designed clinical trials by 4 groups in clinical study, containing CCLSG, TCCSG, KYCCSG and JACLS.
  • Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) was organized in 2003 and includes all four clinical study groups in Japan.
  • The 2004 ALL protocol of Childhood Cancer and Leukemia Group in Japan (CCLSG) contained a new 2-step stratification based on initial age/WBC count and minimal residual disease at day 91.
  • [MeSH-major] Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
  • [MeSH-minor] Antineoplastic Protocols. Child. Child, Preschool. Humans. Infant. Leukocyte Count. Prognosis. Survival Rate

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  • (PMID = 17301519.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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68. Stanulla M, Schrappe M: Treatment of childhood acute lymphoblastic leukemia. Semin Hematol; 2009 Jan;46(1):52-63
Genetic Alliance. consumer health - Acute Lymphoblastic Leukemia, Childhood.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of childhood acute lymphoblastic leukemia.
  • Childhood acute lymphoblastic leukemia (ALL) is the most common malignancy of childhood.
  • Studies in ALL have been a model for clinical and basic research beyond pediatric hemato-oncology.
  • As a result of sustained and well-organized research efforts since the early 1960s, childhood ALL now can be successfully treated in about 80% of patients by the application of intensive combination chemotherapy regimens, which in specific patient subgroups may need to be supplemented with radiation therapy and/or hematopoietic stem cell transplantation.
  • Thus, future research must extend our molecular understanding of leukemia and host factors in order to even more specifically identify the mechanisms underlying the differences in treatment response and outcome, and to finally address the therapeutic needs of the individual child.
  • [MeSH-major] Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
  • [MeSH-minor] Child. Child, Preschool. Humans. Recurrence. Remission Induction. Treatment Outcome

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  • (PMID = 19100368.001).
  • [ISSN] 0037-1963
  • [Journal-full-title] Seminars in hematology
  • [ISO-abbreviation] Semin. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 101
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69. Nebral K, Denk D, Attarbaschi A, König M, Mann G, Haas OA, Strehl S: Incidence and diversity of PAX5 fusion genes in childhood acute lymphoblastic leukemia. Leukemia; 2009 Jan;23(1):134-43
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Incidence and diversity of PAX5 fusion genes in childhood acute lymphoblastic leukemia.
  • PAX5, a master regulator of B-cell development, was recently shown to be involved in several leukemia-associated rearrangements, which result in fusion genes encoding chimeric proteins that antagonize PAX5 transcriptional activity.
  • In a population-based fluorescence in situ hybridization screening study of 446 childhood acute lymphoblastic leukemia (ALL) patients, we now show that PAX5 rearrangements occur at an incidence of about 2.5% of B-cell precursor ALL.
  • [MeSH-major] B-Cell-Specific Activator Protein / genetics. Oncogene Proteins, Fusion / genetics. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Humans. Infant. Signal Transduction / genetics. Transcription Factors / genetics. Transcription, Genetic. Young Adult

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  • (PMID = 19020546.001).
  • [ISSN] 1476-5551
  • [Journal-full-title] Leukemia
  • [ISO-abbreviation] Leukemia
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / B-Cell-Specific Activator Protein; 0 / Oncogene Proteins, Fusion; 0 / PAX5 protein, human; 0 / Transcription Factors
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70. Teuffel O, Stanulla M, Cario G, Ludwig WD, Rottgers S, Schafer BW, Zimmermann M, Schrappe M, Niggli FK: Anemia and survival in childhood acute lymphoblastic leukemia. Haematologica; 2008 Nov;93(11):1652-7
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  • [Title] Anemia and survival in childhood acute lymphoblastic leukemia.
  • BACKGROUND: Several studies have demonstrated that patients with childhood acute lymphoblastic leukemia presenting with mild anemia at diagnosis have an increased risk of poor outcome compared to patients with more severe anemia.
  • However, it has not been reported whether there is any correlation between degree of anemia and leukemia subtype.
  • DESIGN AND METHODS: In a cohort of 1162 patients with childhood acute lymphoblastic leukemia we analyzed whether there was a correlation between degree of anemia and leukemia subtype.
  • The degree of anemia was significantly different for three distinct groups of patients compared to the remaining patients (mean hemoglobin; T-cell leukemia: 106 g/L versus 76 g/L (precursor B-cell acute lymphoblastic leukemia); within precursor B-cell ALL: TEL-AML1 positive: 68 g/L versus 79 g/L; BCR-ABL positive: 93 g/L versus 76 g/L; each p<0.05).
  • Furthermore, in contrast to the entire study group, patients with T-cell leukemia, TEL-AML1(+), and BCR-ABL(+) precursor B-cell leukemia had a more favorable prognosis if presenting with a higher hemoglobin level (>/=80 g/L).
  • CONCLUSIONS: These observations indicate that the formerly reported direct correlation between severity of anemia and survival in childhood acute lymphoblastic leukemia mainly reflects differences in the degree of anemia between distinct biological subgroups with different treatment outcomes.
  • [MeSH-major] Anemia / epidemiology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications. Precursor Cell Lymphoblastic Leukemia-Lymphoma / mortality
  • [MeSH-minor] Burkitt Lymphoma / complications. Burkitt Lymphoma / genetics. Burkitt Lymphoma / mortality. Child. Cohort Studies. Core Binding Factor Alpha 2 Subunit / genetics. Disease-Free Survival. Fusion Proteins, bcr-abl / genetics. Hemoglobins / metabolism. Homeodomain Proteins / genetics. Humans. Leukemia, T-Cell / complications. Leukemia, T-Cell / genetics. Leukemia, T-Cell / mortality. Leukocyte Count. Mutation. Oncogene Proteins, Fusion / genetics. Risk Factors. Survival Analysis. Treatment Outcome

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  • (PMID = 18815194.001).
  • [ISSN] 1592-8721
  • [Journal-full-title] Haematologica
  • [ISO-abbreviation] Haematologica
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Core Binding Factor Alpha 2 Subunit; 0 / Hemoglobins; 0 / Homeodomain Proteins; 0 / Oncogene Proteins, Fusion; 0 / RUNX1 protein, human; 146150-85-8 / E2A-Pbx1 fusion protein; EC 2.7.10.2 / Fusion Proteins, bcr-abl
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71. Kikuchi A, Maeda M, Hanada R, Okimoto Y, Ishimoto K, Kaneko T, Ikuta K, Tsuchida M, Tokyo Children's Cancer Study Group (TCCSG): Moyamoya syndrome following childhood acute lymphoblastic leukemia. Pediatr Blood Cancer; 2007 Mar;48(3):268-72
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  • [Title] Moyamoya syndrome following childhood acute lymphoblastic leukemia.
  • BACKGROUND: Long-term survivors of childhood acute lymphoblastic leukemia (ALL) sometimes suffer from adverse long-term sequelae.
  • We analyzed the incidence, clinical course and prognosis of moyamoya syndrome (MoS) following childhood ALL.
  • RESULTS: Six patients with MoS were identified: four boys and two girls whose ages ranged from 2 years and 1 month (abbreviated as "2y1m") to 14y 1 m at diagnosis of ALL.
  • None of the patients had central nervous system (CNS) leukemia.
  • [MeSH-major] Cranial Irradiation / adverse effects. Moyamoya Disease / etiology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications
  • [MeSH-minor] Adolescent. Anthracyclines / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Asparaginase / administration & dosage. Cerebral Infarction / etiology. Child. Child, Preschool. Combined Modality Therapy. Cyclophosphamide / administration & dosage. Dexamethasone / administration & dosage. Disease Susceptibility. Female. Follow-Up Studies. Humans. Incidence. Japan / epidemiology. Male. Prednisolone / administration & dosage. Quality of Life. Remission Induction. Vincristine / administration & dosage

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16615044.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anthracyclines; 5J49Q6B70F / Vincristine; 7S5I7G3JQL / Dexamethasone; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; EC 3.5.1.1 / Asparaginase
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72. Pui CH: Recent research advances in childhood acute lymphoblastic leukemia. J Formos Med Assoc; 2010 Nov;109(11):777-87
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  • [Title] Recent research advances in childhood acute lymphoblastic leukemia.
  • Recent progress in risk-adapted treatment for childhood acute lymphoblastic leukemia has secured 5-year event-free survival rates of approximately 80% and 5-year survival rates approaching 90%.
  • As high-resolution, genome-wide analyses of leukemic and normal host cells continue to identify novel subtypes of lymphoblastic leukemia and provide new insights into leukemogenesis, we can look forward to the time when all cases of this disease will be classified according to specific genetic abnormalities, some of which will yield "druggable" targets for more effective and less toxic treatments.
  • Meanwhile, it is sobering to consider that a significant fraction of leukemia survivors will develop serious health problems within 30 years of their initial diagnosis.
  • The ultimate challenge is to gain a clear understanding of the factors that give rise to childhood leukemia in the first place, and enable preventive strategies to be devised and implemented.

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  • [Copyright] Copyright © 2010 Formosan Medical Association & Elsevier. Published by Elsevier B.V. All rights reserved.
  • (PMID = 21126650.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA-21765
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Singapore
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73. Rull RP, Gunier R, Von Behren J, Hertz A, Crouse V, Buffler PA, Reynolds P: Residential proximity to agricultural pesticide applications and childhood acute lymphoblastic leukemia. Environ Res; 2009 Oct;109(7):891-9
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  • [Title] Residential proximity to agricultural pesticide applications and childhood acute lymphoblastic leukemia.
  • Ambient exposure from residential proximity to applications of agricultural pesticides may contribute to the risk of childhood acute lymphoblastic leukemia (ALL).
  • Using residential histories collected from the families of 213 ALL cases and 268 matched controls enrolled in the Northern California Childhood Leukemia Study, the authors assessed residential proximity within a half-mile (804.5m) of pesticide applications by linking address histories with reports of agricultural pesticide use.
  • Proximity was ascertained during different time windows of exposure, including the first year of life and the child's lifetime through the date of diagnosis for cases or reference for controls.
  • These findings suggest future directions for the identification of specific pesticides that may play a role in the etiology of childhood leukemia.

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  • (PMID = 19700145.001).
  • [ISSN] 1096-0953
  • [Journal-full-title] Environmental research
  • [ISO-abbreviation] Environ. Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01-CA92674; United States / NIEHS NIH HHS / ES / R01 ES009137-01A1; United States / NIEHS NIH HHS / ES / ES009137-01A1; United States / NCI NIH HHS / CA / R01 CA092674-01A1; United States / NIEHS NIH HHS / ES / R01-ES09137; United States / NCI NIH HHS / CA / CA092674-01A1; United States / NIEHS NIH HHS / ES / R01 ES009137; United States / NCI NIH HHS / CA / R01 CA092674
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Pesticides
  • [Other-IDs] NLM/ NIHMS138328; NLM/ PMC2748130
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74. Spasova MI, Stoyanova AA, Moumdjiev IN, Dimitrov HK: Childhood acute lymphoblastic leukemia presenting with osteoarticular syndrome--characteristics and prognosis. Folia Med (Plovdiv); 2009 Jan-Mar;51(1):50-5
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  • [Title] Childhood acute lymphoblastic leukemia presenting with osteoarticular syndrome--characteristics and prognosis.
  • Children with leukemia often present with osteoarticular syndrome as a first complaint thus mimicking juvenile idiopathic arthritis.
  • The objective of the present study was to determine the frequency of osteoarticular syndrome at the onset of acute lymphoblastic leukemia in childhood, the clinical and laboratory specificity of such patients and the prognostic value of osteoarticular syndrome as an initial symptom.
  • PATIENTS AND METHODS: We studied 60 children with acute lymphoblastic leukemia at a mean age of 5 +/- 0.5 years between February 2002 and October 2007.
  • RESULTS: Osteoarticular syndrome was present as an initial symptom of leukemia in 18 (30.5%) patients.
  • Event-free survival in patients with osteoarticular syndrome is comparable to that of the remaining group of acute lymphoblastic leukemia patients.
  • [MeSH-major] Arthritis, Juvenile / diagnosis. Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
  • [MeSH-minor] Adolescent. Bulgaria / epidemiology. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Joints / pathology. Joints / physiopathology. Leukocyte Count. Male. Prognosis. Survival Rate


75. Harila MJ, Winqvist S, Lanning M, Bloigu R, Harila-Saari AH: Progressive neurocognitive impairment in young adult survivors of childhood acute lymphoblastic leukemia. Pediatr Blood Cancer; 2009 Aug;53(2):156-61
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  • [Title] Progressive neurocognitive impairment in young adult survivors of childhood acute lymphoblastic leukemia.
  • BACKGROUND: Despite the extensive literature on neuropsychological sequelae after treatment of childhood acute lymphoblastic leukemia (ALL), the very-long-term neurocognitive outcome of the survivors is poorly studied.
  • We assessed neuropsychological functioning in a population-based cohort of young adult childhood ALL survivors.
  • CONCLUSIONS: Survivors of childhood ALL suffer from long-lasting progressive neuropsychological impairment, especially when treatment includes cranial irradiation.
  • [MeSH-major] Brain Neoplasms / complications. Cognition Disorders / epidemiology. Cognition Disorders / etiology. Cranial Irradiation / adverse effects. Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications
  • [MeSH-minor] Adolescent. Adult. Age of Onset. Antineoplastic Agents / adverse effects. Child. Child, Preschool. Combined Modality Therapy. Disease Progression. Female. Humans. Infant. Infant, Newborn. Male. Neuropsychological Tests. Survivors. Young Adult


76. Avellino R, Romano S, Parasole R, Bisogni R, Lamberti A, Poggi V, Venuta S, Romano MF: Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells. Blood; 2005 Aug 15;106(4):1400-6
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  • [Title] Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells.
  • The phosphatidyl-inositol 3 kinase (PI3k)/Akt pathway has been implicated in childhood acute lymphoblastic leukemia (ALL).
  • Using a short interfering (si) RNA approach, we demonstrate that FKBP51, a large immunophilin inhibited by rapamycin, is essential for drug-induced NF-kappaB activation in human leukemia.
  • In conclusion, rapamycin targets 2 pathways that are crucial for cell survival and chemoresistance of malignant lymphoblasts--PI3k/Akt through the mammalian target of rapamycin and NF-kappaB through FKBP51--suggesting that the drug could be beneficial in the treatment of childhood ALL.
  • [MeSH-major] Apoptosis / drug effects. Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology. Signal Transduction. Sirolimus / pharmacology
  • [MeSH-minor] Adolescent. Blast Crisis / drug therapy. Blast Crisis / pathology. Bone Marrow Cells / drug effects. Bone Marrow Cells / pathology. Child. Child, Preschool. Doxorubicin / pharmacology. Drug Synergism. Female. Humans. Infant. Male. NF-kappa B / metabolism. Phosphatidylinositol 3-Kinases / metabolism. Protein-Serine-Threonine Kinases / metabolism. Proto-Oncogene Proteins / metabolism. Proto-Oncogene Proteins c-akt. Tacrolimus Binding Proteins / metabolism. Tumor Cells, Cultured


77. Ivanovski PI, Ivanovski IP: Childhood acute lymphoblastic leukemia is triggered by the introduction of immunization against diphtheria. Med Hypotheses; 2007;68(2):324-7
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  • [Title] Childhood acute lymphoblastic leukemia is triggered by the introduction of immunization against diphtheria.
  • BACKGROUND: Childhood acute lymphoblastic leukemia has prenatal origin.
  • Leukemogenic translocations originating during fetal life are insufficient for overt leukemia.
  • Transgenic TEL-AML1 mice have failed to develop leukemia.
  • Since then, childhood leukemia has almost unchangeable incidence.
  • HYPOTHESIS: Childhood acute lymphoblastic leukemia is triggered by vaccination against diphtheria.
  • TESTING THE HYPOTHESIS: Epidemiological survey for leukemia cases among "exemptors" and unvaccinated cases among ALL children should be done.
  • IMPLICATIONS OF THE HYPOTHESIS: If there is no leukemia among the "exemptors", no unvaccinated among ALL, and some mice develop leukemia upon vaccination childhood leukemia will be prevented by massive neonatal screening for leukemogenic genetics and/or with a new vaccination schedule.
  • [MeSH-major] Diphtheria Toxoid / adverse effects. Precursor Cell Lymphoblastic Leukemia-Lymphoma / etiology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology
  • [MeSH-minor] Animals. Child. Disease Models, Animal. Humans. Incidence. Mice


78. Woo HY, Kim DW, Park H, Seong KW, Koo HH, Kim SH: Molecular cytogenetic analysis of gene rearrangements in childhood acute lymphoblastic leukemia. J Korean Med Sci; 2005 Feb;20(1):36-41
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  • [Title] Molecular cytogenetic analysis of gene rearrangements in childhood acute lymphoblastic leukemia.
  • The aims of this study were to estimate the incidences of BCR/ABL, MLL, TEL/AML1 rearrangements, and p16 deletions in childhood acute lymphoblastic leukemia (ALL), to identify new abnormalities, and to demonstrate the usefulness of interphase fluorescence in situ hybridization (FISH).
  • We performed G-banding analysis and FISH using probes for BCR/ABL, MLL, TEL/AML1 rearrangements, and p16 deletions on 65 childhood ALL patients diagnosed and uniformly treated at a single hospital.
  • We established the rough incidences of gene rearrangements in childhood ALL, found new abnormalities and demonstrated the diagnostic capability of interphase FISH to identify cryptic chromosome aberrations.
  • [MeSH-major] Chromosome Aberrations. Cyclin-Dependent Kinase Inhibitor p16 / genetics. DNA-Binding Proteins / genetics. Fusion Proteins, bcr-abl / genetics. Gene Rearrangement. Oncogene Proteins, Fusion / genetics. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics. Proto-Oncogenes / genetics. Transcription Factors / genetics
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Chromosome Banding. Core Binding Factor Alpha 2 Subunit. Female. Gene Deletion. Histone-Lysine N-Methyltransferase. Humans. In Situ Hybridization, Fluorescence. Infant. Interphase. Male. Myeloid-Lymphoid Leukemia Protein. Treatment Outcome

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  • (PMID = 15716599.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Core Binding Factor Alpha 2 Subunit; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA-Binding Proteins; 0 / MLL protein, human; 0 / Oncogene Proteins, Fusion; 0 / TEL-AML1 fusion protein; 0 / Transcription Factors; 149025-06-9 / Myeloid-Lymphoid Leukemia Protein; EC 2.1.1.43 / Histone-Lysine N-Methyltransferase; EC 2.7.10.2 / Fusion Proteins, bcr-abl
  • [Other-IDs] NLM/ PMC2808572
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79. Dengel DR, Ness KK, Glasser SP, Williamson EB, Baker KS, Gurney JG: Endothelial function in young adult survivors of childhood acute lymphoblastic leukemia. J Pediatr Hematol Oncol; 2008 Jan;30(1):20-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endothelial function in young adult survivors of childhood acute lymphoblastic leukemia.
  • BACKGROUND: Adult survivors of childhood acute lymphoblastic leukemia (ALL) have an earlier than expected mortality from cardiovascular disease.
  • This study examined endothelial function in 75 young (age 30.2+/-7.1 y) adult survivors of childhood ALL who received chemotherapy without cranial radiation (n=25) or chemotherapy combined with cranial radiation (n=50) compared with a healthy control group of similar sex, age, and weight (n=59).
  • CONCLUSIONS: These data suggest that young adults treated for ALL during childhood are at risk for impaired FMD regardless of whether or not they received cranial irradiation.
  • The extent to which this mechanism relates to early development of cardiovascular disease in long-term childhood ALL survivors remains to be determined.
  • [MeSH-major] Brachial Artery / physiopathology. Endothelium, Vascular / physiopathology. Nitroglycerin / administration & dosage. Precursor Cell Lymphoblastic Leukemia-Lymphoma / physiopathology. Vasodilation / drug effects. Vasodilator Agents / administration & dosage
  • [MeSH-minor] Adult. Child. Child, Preschool. Cranial Irradiation. Female. Follow-Up Studies. Humans. Male. Sex Factors. Survivors

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  • (PMID = 18176175.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / M01-RR00400; United States / NCI NIH HHS / CA / R21-CA106778; United States / NCI NIH HHS / CA / U24-CA55727
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vasodilator Agents; G59M7S0WS3 / Nitroglycerin
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80. Olsen M, Hjalgrim LL, Madsen HO, Hjalgrim H, Schmiegelow K: [Chromosome changes associated with childhood leukaemia occur prenatally]. Ugeskr Laeger; 2006 May 29;168(22):2152-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Chromosome changes associated with childhood leukaemia occur prenatally].
  • [Transliterated title] Kromosomforandringer associeret med leukaemi hos børn opstår praenatalt.
  • Leukaemia is the most common cancer in childhood, yet only a few risk factors have been identified.
  • Studies of monozygotic twins with concordant leukaemia and retrospective analyses of neonatal blood spots from children with leukaemia indicate that chromosomal translocations characteristic of childhood leukaemia often occur prenatally.
  • The chromosomal translocations may be initiators of the leukaemia development but per se are insufficient to cause the disease.
  • The findings provide a basic understanding of the natural history of childhood leukaemia and may make the development of preventive measures feasible.
  • [MeSH-major] Chromosome Aberrations / embryology. Leukemia, Monocytic, Acute / genetics. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • [MeSH-minor] Child, Preschool. Chromosome Deletion. Gene Fusion. Humans. Infant. Infant, Newborn. Phenylketonurias / genetics. Preleukemia / embryology. Preleukemia / genetics. Risk Factors. Translocation, Genetic. Twins, Monozygotic / genetics

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  • (PMID = 16768953.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Denmark
  • [Number-of-references] 40
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81. Azevedo-Silva F, Reis Rde S, Santos Mde O, Luiz RR, Pombo-de-Oliveira MS: Evaluation of childhood acute leukemia incidence and underreporting in Brazil by capture-recapture methodology. Cancer Epidemiol; 2009 Dec;33(6):403-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of childhood acute leukemia incidence and underreporting in Brazil by capture-recapture methodology.
  • Childhood acute lymphoblastic leukemia (ALL) is said to have lower incidence in developing countries, which has implications for its pathogenesis, but there are few studies concerning the completeness of cancer registries in developing countries.
  • This study analyzes the number of cases and incidence of childhood acute lymphoblastic leukemia in three different cities in Brazil and estimates underreporting cases and possible PBCR failures.
  • METHODS: We evaluated the completeness of PBCR and the incidence rates of childhood ALL from three different Brazilian cities using the two-source capture-recapture method.
  • The estimated completeness of childhood ALL in PBCRs was 15.5%, 35.4% and 29.2%, respectively, for Salvador, Recife and Belo Horizonte.
  • CONCLUSIONS: There was a high estimated underreporting of childhood leukemia cases in some Brazilian cities.
  • Childhood acute lymphoblastic leukemia incidence rates are similar to those of developed countries.
  • [MeSH-major] Disease Notification / statistics & numerical data. Population Surveillance. Precursor Cell Lymphoblastic Leukemia-Lymphoma / epidemiology
  • [MeSH-minor] Adolescent. Brazil / epidemiology. Child. Child, Preschool. Female. Humans. Incidence. Infant. Male. Registries

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  • [CommentIn] Cancer Epidemiol. 2009 Dec;33(6):401-2 [19932647.001]
  • (PMID = 19833572.001).
  • [ISSN] 1877-783X
  • [Journal-full-title] Cancer epidemiology
  • [ISO-abbreviation] Cancer Epidemiol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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82. Davidsen ML, Dalhoff K, Schmiegelow K: Pharmacogenetics influence treatment efficacy in childhood acute lymphoblastic leukemia. J Pediatr Hematol Oncol; 2008 Nov;30(11):831-49
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pharmacogenetics influence treatment efficacy in childhood acute lymphoblastic leukemia.
  • As most childhood acute lymphoblastic leukemia treatment protocols include up to 13 different chemotherapeutic agents, the impact of individual SNPs has been difficult to evaluate.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Neoplasm Proteins / genetics. Polymorphism, Genetic. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics


83. Golumbek P: Pharmacologic agents for pediatric neuroimmune disorders. Semin Pediatr Neurol; 2010 Dec;17(4):245-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pharmacologic agents for pediatric neuroimmune disorders.
  • Autoimmune diseases make up a significant portion of the acute and chronic caseload of all pediatric neurologists.
  • This article provides an overview of the current therapeutic options as they relate to the more common pediatric neuroimmune disorders.
  • [MeSH-minor] Age Factors. Child. Humans

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 21183131.001).
  • [ISSN] 1558-0776
  • [Journal-full-title] Seminars in pediatric neurology
  • [ISO-abbreviation] Semin Pediatr Neurol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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84. Wang J, Zhan P, Chen B, Zhou R, Yang Y, Ouyang J: MTHFR C677T polymorphisms and childhood acute lymphoblastic leukemia: a meta-analysis. Leuk Res; 2010 Dec;34(12):1596-600
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MTHFR C677T polymorphisms and childhood acute lymphoblastic leukemia: a meta-analysis.
  • To date, case-control studies on the association between methylenetetrahydrofolate reductase (MTHFR) C677T and childhood acute lymphoblastic leukemia have provided either controversial or inconclusive results.
  • To clarify the effect of MTHFR C677T on the risk of childhood acute lymphoblastic leukemia, a meta-analysis of all case-control observational studies was performed.
  • The random effects (RE) model showed that the 677T allele was not associated with a decreased susceptibility risk of childhood acute lymphoblastic leukemia compared with the C allele [OR=0.96, 95% confidence interval (CI) (0.88-1.04), P=0.34].
  • Although MTHFR C677T was associated with increased risks of colorectal cancer, leukemia, and gastric cancer, our pooled data suggest no evidence for a major role of MTHFR C677T in the carcinogenesis of childhood acute lymphoblastic leukemia.
  • [MeSH-major] Alleles. Methylenetetrahydrofolate Dehydrogenase (NADP) / genetics. Models, Biological. Polymorphism, Genetic. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • [MeSH-minor] Adolescent. Case-Control Studies. Child. Child, Preschool. Colorectal Neoplasms / genetics. Female. Homozygote. Humans. Male. Predictive Value of Tests. Risk Factors. Stomach Neoplasms / genetics

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20409583.001).
  • [ISSN] 1873-5835
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] England
  • [Chemical-registry-number] EC 1.5.1.5 / Methylenetetrahydrofolate Dehydrogenase (NADP)
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85. Riedt T, Ebinger M, Salih HR, Tomiuk J, Handgretinger R, Kanz L, Grünebach F, Lengerke C: Aberrant expression of the homeobox gene CDX2 in pediatric acute lymphoblastic leukemia. Blood; 2009 Apr 23;113(17):4049-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aberrant expression of the homeobox gene CDX2 in pediatric acute lymphoblastic leukemia.
  • Consistent with the notion that embryonic pathways can reactivate during adult oncogenesis, recent studies suggest involvement of CDX2 in human acute myeloid leukemia (AML).
  • Here we study CDX2 in healthy and leukemic human lymphoid cells, and show that a majority of leukemic samples display various degrees of aberrant CDX2 expression.
  • Analysis of a cohort of 37 childhood acute lymphoblastic leukemia (ALL) patients treated in our hospital reveals that high CDX2 expression levels at diagnosis correlate with persistence of minimal residual disease (MRD) during the course of treatment.
  • Thus, CDX2 expression levels may serve as a marker for adverse prognosis in pediatric ALL.
  • [MeSH-major] Gene Expression Regulation, Neoplastic / genetics. Homeodomain Proteins / metabolism. Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism
  • [MeSH-minor] Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Case-Control Studies. Child. Humans. Transcription, Genetic / genetics

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  • (PMID = 19218548.001).
  • [ISSN] 1528-0020
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins
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86. Kalmanti L, Dampaki K, Dimitriou H, Stiakaki E, Chaniotis V, Stathopoulos E: A morphometric approach for the evaluation of angiogenesis in acute lymphoblastic leukemia of childhood. Leuk Res; 2005 Jun;29(6):673-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A morphometric approach for the evaluation of angiogenesis in acute lymphoblastic leukemia of childhood.
  • Angiogenesis was estimated in childhood acute lymphoblastic leukemia (ALL) by the use of a novel morphometric method.
  • [MeSH-major] Bone Marrow Cells / pathology. Neovascularization, Pathologic / diagnosis. Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
  • [MeSH-minor] Analysis of Variance. Bone Marrow Examination / methods. Child. Female. Humans. Immunohistochemistry. Male

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  • (PMID = 15863208.001).
  • [ISSN] 0145-2126
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] England
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87. Milne E, Laurvick CL, de Klerk N, Robertson L, Thompson JR, Bower C: Trends in childhood acute lymphoblastic leukemia in Western Australia, 1960-2006. Int J Cancer; 2008 Mar 1;122(5):1130-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Trends in childhood acute lymphoblastic leukemia in Western Australia, 1960-2006.
  • Increases in the incidence of childhood acute lymphoblastic leukemia (ALL) have been reported in some countries, while other reports from similar geographical regions have indicated stable rates.
  • We used population-based data from Western Australia to investigate trends in the incidence of childhood ALL between 1960 and 2006.
  • [MeSH-major] Precursor Cell Lymphoblastic Leukemia-Lymphoma / epidemiology
  • [MeSH-minor] Adolescent. Australia / epidemiology. Child. Child, Preschool. Female. Humans. Incidence. Male. Registries


88. Pakakasama S, Sirirat T, Kanchanachumpol S, Udomsubpayakul U, Mahasirimongkol S, Kitpoka P, Thithapandha A, Hongeng S: Genetic polymorphisms and haplotypes of DNA repair genes in childhood acute lymphoblastic leukemia. Pediatr Blood Cancer; 2007 Jan;48(1):16-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genetic polymorphisms and haplotypes of DNA repair genes in childhood acute lymphoblastic leukemia.
  • This study was performed to evaluate the effect of the polymorphisms of DNA repair genes on risk of childhood acute lymphoblastic leukemia (ALL).
  • CONCLUSION: The XRCC1 194Trp allele and haplotype B showed a protective effect against development of childhood ALL.
  • [MeSH-major] Alleles. DNA Repair. DNA-Binding Proteins / genetics. Genetic Predisposition to Disease. Polymorphism, Genetic. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Gene Frequency / genetics. Haplotypes. Humans. Infant. Male. Mutation, Missense. Retrospective Studies. Risk Factors

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16435384.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / X-ray repair cross complementing protein 1
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89. Milne E, Royle JA, de Klerk NH, Blair E, Bailey H, Cole C, Attia J, Scott RJ, Armstrong BK: Fetal growth and risk of childhood acute lymphoblastic leukemia: results from an Australian case-control study. Am J Epidemiol; 2009 Jul 15;170(2):221-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fetal growth and risk of childhood acute lymphoblastic leukemia: results from an Australian case-control study.
  • The relation between intrauterine growth and risk of childhood acute lymphoblastic leukemia was investigated in an Australian population-based case-control study that included 347 cases and 762 controls aged <15 years recruited from 2003 to 2006.
  • Risk of acute lymphoblastic leukemia was positively associated with proportion of optimal birth weight; the odds ratio for a 1-standard-deviation increase in proportion of optimal birth weight was 1.18 (95% confidence interval: 1.04, 1.35) after adjustment for the matching variables and potential confounders.
  • This association was also present among children who did not have a high birth weight, suggesting that accelerated growth, rather than high birth weight per se, is associated with risk of acute lymphoblastic leukemia.
  • Similar associations between proportion of optimal birth weight and acute lymphoblastic leukemia were observed for both sexes and across age groups and leukemia subtypes.
  • Results of this study confirm earlier findings of a positive association between rapidity of fetal growth and subsequent risk of acute lymphoblastic leukemia in childhood, and they are consistent with a role for insulin-like growth factors in the causal pathway.
  • [MeSH-major] Birth Weight. Fetal Development. Fetal Growth Retardation. Precursor Cell Lymphoblastic Leukemia-Lymphoma / epidemiology


90. Banklau C, Jindadamrongwech S, Sawangpanich R, Apibal S, Hongeng S, Paisooksantivatana K, Pakakasama S: Effect of genetic alterations of cytarabine- metabolizing enzymes in childhood acute lymphoblastic leukemia. Hematol Oncol Stem Cell Ther; 2010;3(3):103-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of genetic alterations of cytarabine- metabolizing enzymes in childhood acute lymphoblastic leukemia.
  • Currently, treatment of childhood acute lymphoblastic leukemia (ALL) includes cytarabine, especially in high-risk patients.
  • PATIENTS AND METHODS: We included children diagnosed with ALL and lymphoblastic lymphoma (LL) stage III and IV.
  • All four SNPs showed predominant wild type alleles.
  • CONCLUSION: The dCK-360G allele was found to increase the risk of mucositis after exposure to low-dose cytarabine in childhood ALL therapy.
  • [MeSH-major] Cytarabine / therapeutic use. Cytidine Deaminase / genetics. Deoxycytidine Kinase / genetics. Polymorphism, Single Nucleotide. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • [MeSH-minor] Adolescent. Alleles. Antigens, CD19 / metabolism. Antigens, CD45 / metabolism. Antimetabolites, Antineoplastic / adverse effects. Antimetabolites, Antineoplastic / metabolism. Antimetabolites, Antineoplastic / therapeutic use. Child. Child, Preschool. Dose-Response Relationship, Drug. Female. Flow Cytometry. Gene Frequency. Genotype. Humans. Infant. Male. Mucositis / chemically induced. Neoplasm Staging. Neoplasm, Residual / diagnosis. Neoplasm, Residual / genetics. Neoplasm, Residual / metabolism. Thrombocytopenia / chemically induced. Treatment Outcome

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  • (PMID = 20890066.001).
  • [ISSN] 1658-3876
  • [Journal-full-title] Hematology/oncology and stem cell therapy
  • [ISO-abbreviation] Hematol Oncol Stem Cell Ther
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Antigens, CD19; 0 / Antimetabolites, Antineoplastic; 04079A1RDZ / Cytarabine; EC 2.7.1.74 / Deoxycytidine Kinase; EC 3.1.3.48 / Antigens, CD45; EC 3.5.4.5 / Cytidine Deaminase
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91. Mullighan CG, Zhang J, Harvey RC, Collins-Underwood JR, Schulman BA, Phillips LA, Tasian SK, Loh ML, Su X, Liu W, Devidas M, Atlas SR, Chen IM, Clifford RJ, Gerhard DS, Carroll WL, Reaman GH, Smith M, Downing JR, Hunger SP, Willman CL: JAK mutations in high-risk childhood acute lymphoblastic leukemia. Proc Natl Acad Sci U S A; 2009 Jun 9;106(23):9414-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] JAK mutations in high-risk childhood acute lymphoblastic leukemia.
  • Pediatric acute lymphoblastic leukemia (ALL) is a heterogeneous disease consisting of distinct clinical and biological subtypes that are characterized by specific chromosomal abnormalities or gene mutations.
  • We recently identified a poor prognostic subgroup of pediatric BCR-ABL1-negative ALL patients characterized by deletion of IKZF1 (encoding the lymphoid transcription factor IKAROS) and a gene expression signature similar to BCR-ABL1-positive ALL, raising the possibility of activated tyrosine kinase signaling within this leukemia subtype.
  • Here, we report activating mutations in the Janus kinases JAK1 (n = 3), JAK2 (n = 16), and JAK3 (n = 1) in 20 (10.7%) of 187 BCR-ABL1-negative, high-risk pediatric ALL cases.
  • The JAK-mutated cases had a gene expression signature similar to BCR-ABL1 pediatric ALL, and they had a poor outcome.

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  • (PMID = 19470474.001).
  • [ISSN] 1091-6490
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA118100; United States / NCI NIH HHS / CA / U10 CA98413; United States / NCI NIH HHS / CA / L40 CA142226; United States / NCI NIH HHS / CA / U01 CA114762; United States / NCI NIH HHS / CA / CA114762; United States / NCI NIH HHS / CA / U10 CA098413; United States / PHS HHS / / N01-C0-12400; United States / NCI NIH HHS / CA / CA098543; United States / Howard Hughes Medical Institute / / ; United States / NICHD NIH HHS / HD / T32 HD044331; United States / NCI NIH HHS / CA / U10 CA098543; United States / NCI NIH HHS / CA / T32 CA128583; United States / NCI NIH HHS / CA / U10 CA98543
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / IKZF1 protein, human; 148971-36-2 / Ikaros Transcription Factor; EC 2.7.10.2 / Janus Kinase 1; EC 2.7.10.2 / Janus Kinase 3; EC 2.7.10.2 / Janus Kinases
  • [Other-IDs] NLM/ PMC2695045
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92. Graubner UB, Porzig S, Jorch N, Kolb R, Wessalowski R, Escherich G, Janka GE: Impact of reduction of therapy on infectious complications in childhood acute lymphoblastic leukemia. Pediatr Blood Cancer; 2008 Feb;50(2):259-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Impact of reduction of therapy on infectious complications in childhood acute lymphoblastic leukemia.
  • BACKGROUND: Infections are a major cause of morbidity and mortality in childhood acute lymphoblastic leukemia (ALL) and only limited information is available on infectious complications.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Infection / etiology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Precursor Cell Lymphoblastic Leukemia-Lymphoma / microbiology
  • [MeSH-minor] Child. Child, Preschool. Female. Humans. Infant. Male. Risk Factors. Treatment Outcome

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17635005.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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93. Bachmann PS, Gorman R, Papa RA, Bardell JE, Ford J, Kees UR, Marshall GM, Lock RB: Divergent mechanisms of glucocorticoid resistance in experimental models of pediatric acute lymphoblastic leukemia. Cancer Res; 2007 May 1;67(9):4482-90
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  • [Title] Divergent mechanisms of glucocorticoid resistance in experimental models of pediatric acute lymphoblastic leukemia.
  • Cell line models of glucocorticoid resistance in childhood acute lymphoblastic leukemia (ALL) almost invariably exhibit altered glucocorticoid receptor (GR) function.
  • However, these findings are incongruous with those using specimens derived directly from leukemia patients, in which GR alterations are rarely found.
  • We present a novel paradigm of glucocorticoid resistance in childhood ALL, in which patient biopsies have been directly established as continuous xenografts in immune-deficient mice, without prior in vitro culture.
  • This finding contrasts with five commonly used leukemia cell lines, all of which exhibited defective GRE binding.
  • Furthermore, the receptor tyrosine kinase inhibitor, SU11657, completely reversed dexamethasone resistance in a xenograft expressing functional GR, indicating that pharmacologic reversal of glucocorticoid resistance in childhood ALL is achievable.
  • [MeSH-major] Dexamethasone / pharmacology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Receptors, Glucocorticoid / metabolism
  • [MeSH-minor] Animals. Apoptosis Regulatory Proteins / biosynthesis. Apoptosis Regulatory Proteins / genetics. Child. Gene Expression Regulation, Neoplastic. Humans. Membrane Proteins / biosynthesis. Membrane Proteins / genetics. Mice. Mice, Inbred NOD. Mice, SCID. Organic Chemicals / pharmacology. Proto-Oncogene Proteins / biosynthesis. Proto-Oncogene Proteins / genetics. Receptor Protein-Tyrosine Kinases / antagonists & inhibitors. Transcription Factors / biosynthesis. Transcription Factors / genetics. Transcription, Genetic. Xenograft Model Antitumor Assays

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  • (PMID = 17483364.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / Bcl-2-like protein 11; 0 / Membrane Proteins; 0 / Organic Chemicals; 0 / Proto-Oncogene Proteins; 0 / Receptors, Glucocorticoid; 0 / SU 11657; 0 / TSC22D3 protein, human; 0 / Transcription Factors; 7S5I7G3JQL / Dexamethasone; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases
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94. Fangusaro J: Pediatric high-grade gliomas and diffuse intrinsic pontine gliomas. J Child Neurol; 2009 Nov;24(11):1409-17
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  • [Title] Pediatric high-grade gliomas and diffuse intrinsic pontine gliomas.
  • Pediatric high-grade gliomas represent approximately 10% of all pediatric brain tumors.
  • In this review, we present an overview of both pediatric high-grade gliomas and diffuse intrinsic pontine gliomas with a focus on their epidemiology, etiology, presentation, prognostic factors, biology, treatment modalities, outcomes, and future research directions.
  • [MeSH-minor] Child. Humans. Models, Neurological. Neoplasm Staging

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  • (PMID = 19638636.001).
  • [ISSN] 1708-8283
  • [Journal-full-title] Journal of child neurology
  • [ISO-abbreviation] J. Child Neurol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 83
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95. Abuidris DO, Ahmed ME, Elgaili EM, Arora RS: Childhood cancer in Sudan: 1999-2007. Trop Doct; 2008 Oct;38(4):208-10
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  • [Title] Childhood cancer in Sudan: 1999-2007.
  • There is paucity of information on childhood cancer from Sudan with the last studies published more than 20 years ago.
  • This study aims to provide a current picture of childhood cancer in Sudan.
  • Lymphomas (111, 35%), leukaemia (83, 26%) and Wilms' tumour (43, 13%) were the three most common groups of tumours.
  • Thirty percent of all lymphomas were Burkitt's lymphoma; 3.4% of all childhood cancer cases were nasopharyngeal carcinomas.
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Humans. Infant. Infant, Newborn. Male. Sudan / epidemiology. Time Factors

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  • (PMID = 18820183.001).
  • [ISSN] 0049-4755
  • [Journal-full-title] Tropical doctor
  • [ISO-abbreviation] Trop Doct
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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96. Maniar TN, Braunstein I, Keefe S, Hussen S, Abrams T, De Michele A, El-Deiry WS: Childhood ALL and second neoplasms. Cancer Biol Ther; 2007 Oct;6(10):1525-31
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  • [Title] Childhood ALL and second neoplasms.
  • Second malignancies are a significant concern for survivors of childhood acute lymphoblastic leukemia (ALL), in particular patients who have been treated with cranial irradiation.
  • Breast cancer can occur in association with meningioma, but is not thought to be a consequence of treatment for childhood ALL.
  • We describe the molecular genetics and therapy of childhood ALL, the molecular genetics of meningioma, as well as the possible association between meningioma and breast cancer.
  • [MeSH-major] Breast Neoplasms / epidemiology. Meningeal Neoplasms / epidemiology. Meningioma / epidemiology. Neoplasms, Second Primary / epidemiology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Humans. Male. Risk

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  • (PMID = 17952026.001).
  • [ISSN] 1555-8576
  • [Journal-full-title] Cancer biology & therapy
  • [ISO-abbreviation] Cancer Biol. Ther.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 96
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97. Asner S, Ammann RA, Ozsahin H, Beck-Popovic M, von der Weid NX: Obesity in long-term survivors of childhood acute lymphoblastic leukemia. Pediatr Blood Cancer; 2008 Jul;51(1):118-22
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  • [Title] Obesity in long-term survivors of childhood acute lymphoblastic leukemia.
  • BACKGROUND: Childhood acute lymphoblastic leukemia (ALL) with current cure rates reaching 80% emphasizes the necessity to determine treatment related long-term effects.
  • [MeSH-major] Obesity / etiology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications. Survivors
  • [MeSH-minor] Child. Child, Preschool. Cohort Studies. Family Health. Female. Follow-Up Studies. Humans. Infant. Male. Overweight / etiology. Prevalence. Retrospective Studies. Risk Factors


98. Schotte D, Chau JC, Sylvester G, Liu G, Chen C, van der Velden VH, Broekhuis MJ, Peters TC, Pieters R, den Boer ML: Identification of new microRNA genes and aberrant microRNA profiles in childhood acute lymphoblastic leukemia. Leukemia; 2009 Feb;23(2):313-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Identification of new microRNA genes and aberrant microRNA profiles in childhood acute lymphoblastic leukemia.
  • To identify miRNAs relevant to pediatric acute lymphoblastic leukemia (ALL), we cloned 105 known and 8 new miRNA genes expressed in patients' leukemia cells.
  • Eight miRNAs were differentially expressed between MLL and non-MLL precursor B-ALL cases (P<0.05).
  • Most remarkably, miR-708 was 250- up to 6500-fold higher expressed in 57 TEL-AML1, BCR-ABL, E2A-PBX1, hyperdiploid and B-other cases than in 20 MLL-rearranged and 15 T-ALL cases (0.0001<P<0.01), whereas the expression of miR-196b was 500-fold higher in MLL-rearranged and 800-fold higher in 5 of 15 T-ALL cases as compared with the expression level in the remaining precursor B-ALL cases (P<0.001).
  • The expression did not correlate with the maturation status of leukemia cells based on immunoglobulin and T-cell receptor rearrangements, immunophenotype or MLL-fusion partner.
  • [MeSH-major] MicroRNAs / genetics. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics. RNA, Neoplasm / genetics
  • [MeSH-minor] Cloning, Molecular. Gene Expression Regulation, Neoplastic. Humans. Infant. Infant, Newborn. Myeloid-Lymphoid Leukemia Protein / genetics

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  • (PMID = 18923441.001).
  • [ISSN] 1476-5551
  • [Journal-full-title] Leukemia
  • [ISO-abbreviation] Leukemia
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / MicroRNAs; 0 / RNA, Neoplasm; 149025-06-9 / Myeloid-Lymphoid Leukemia Protein
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99. Athanassiadou F, Tragiannidis A, Rousso I, Katsos G, Sidi V, Papageorgiou T, Papastergiou C, Tsituridis I, Koliouskas D: Bone mineral density in survivors of childhood acute lymphoblastic leukemia. Turk J Pediatr; 2006 Apr-Jun;48(2):101-4
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  • [Title] Bone mineral density in survivors of childhood acute lymphoblastic leukemia.
  • The aim of our study was to evaluate bone metabolism with measurement of bone mineral density (BMD) after management (chemo-, radiotherapy) for childhood acute lymphoblastic leukemia (ALL).
  • [MeSH-major] Antineoplastic Agents / adverse effects. Bone Diseases, Metabolic / etiology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications
  • [MeSH-minor] Absorptiometry, Photon. Bone Density. Case-Control Studies. Child. Female. Humans. Lumbar Vertebrae / radiography. Male. Osteoporosis / etiology. Osteoporosis / radiography. Survivors

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  • (PMID = 16848106.001).
  • [ISSN] 0041-4301
  • [Journal-full-title] The Turkish journal of pediatrics
  • [ISO-abbreviation] Turk. J. Pediatr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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100. Nakamura M, Shimada K, Ishida E, Higuchi T, Nakase H, Sakaki T, Konishi N: Molecular pathogenesis of pediatric astrocytic tumors. Neuro Oncol; 2007 Apr;9(2):113-23
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  • [Title] Molecular pathogenesis of pediatric astrocytic tumors.
  • Astrocytomas are the most common pediatric brain tumors, accounting for 7%-8% of all childhood cancers.
  • Relatively few studies have been performed on their molecular properties; therefore, classification of pediatric astrocytic tumors into genetic subtypes similar to that of adult tumors remains to be defined.
  • Here, we report an extensive characterization of 44 pediatric astrocytomas--16 diffuse astrocytomas (WHO grade II), 10 anaplastic astrocytomas (WHO grade III), and 18 glioblastomas (WHO grade IV)--in terms of genetic alterations frequently observed in adult astrocytomas.
  • Loss of heterozygosity (LOH) on 1p/19q and 10p/10q was less common in pediatric astrocytic tumors than in those seen in adults, but the frequency of LOH on 22q was comparable, occurring in 44% of diffuse astrocytomas, 40% of anaplastic astrocytomas, and 61% of glioblastomas.
  • Our results suggest some differences in children compared to adults in the genetic pathways leading to the formation of de novo astrocytic tumors.
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Chromosomes, Human, Pair 1. Chromosomes, Human, Pair 10. Chromosomes, Human, Pair 19. Chromosomes, Human, Pair 22. DNA Mutational Analysis. Female. Gene Amplification. Genes, p53. Glioblastoma / genetics. Humans. Loss of Heterozygosity. Male. Mutation. PTEN Phosphohydrolase / genetics. Receptor, Epidermal Growth Factor / genetics. Receptor, Platelet-Derived Growth Factor beta / genetics

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  • (PMID = 17327574.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor beta; EC 3.1.3.67 / PTEN Phosphohydrolase
  • [Other-IDs] NLM/ PMC1871665
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