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6. Cannon M, Cesarman E, Boshoff C: KSHV G protein-coupled receptor inhibits lytic gene transcription in primary-effusion lymphoma cells via p21-mediated inhibition of Cdk2. Blood; 2006 Jan 1;107(1):277-84
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  • [Title] KSHV G protein-coupled receptor inhibits lytic gene transcription in primary-effusion lymphoma cells via p21-mediated inhibition of Cdk2.
  • Infection with Kaposi sarcoma-associated herpesvirus (KSHV) is now known to be an etiologic force behind KS and primary-effusion lymphoma (PEL).
  • Over time, KSHV has pirated many human genes whose products regulate angiogenesis, inflammation, and the cell cycle.
  • Although it is considered a viral oncogene and causes KS-like lesions in mice, vGPCR expression results in cell-cycle arrest of KSHV-infected PEL cells.

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  • (PMID = 16150942.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA068 939; United States / NIAID NIH HHS / AI / K08-AI53 971
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / G protein-coupled receptor, Human herpesvirus 8; 0 / Immediate-Early Proteins; 0 / Receptors, Chemokine; 0 / Rta protein, Human herpesvirus 8; 0 / Trans-Activators; 0 / Viral Proteins; EC 2.7.11.22 / CDK2 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 2
  • [Other-IDs] NLM/ PMC1895347
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7. Ren JG, Seth P, Everett P, Clish CB, Sukhatme VP: Induction of erythroid differentiation in human erythroleukemia cells by depletion of malic enzyme 2. PLoS One; 2010 Sep 02;5(9)
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  • [Title] Induction of erythroid differentiation in human erythroleukemia cells by depletion of malic enzyme 2.
  • Higher expression of this enzyme correlates with the degree of cell de-differentiation.
  • We found that ME2 is expressed in K562 erythroleukemia cells, in which a number of agents have been found to induce differentiation either along the erythroid or the myeloid lineage.
  • These findings were accompanied by differentiation of K562 cells along the erythroid lineage, as confirmed by staining for glycophorin A and hemoglobin production.
  • Increased ROS levels, likely reflecting increased mitochondrial production, and a decreased NADPH/NADP+ ratio were noted but use of a free radical scavenger to decrease inhibition of ROS levels did not reverse the differentiation or apoptotic phenotype, suggesting that ROS production is not causally involved in the resultant phenotype.
  • As might be expected, depletion of ME2 induced an increase in the NAD+/NADH ratio and ATP levels fell significantly.
  • We also examined several intracellular signaling pathways and expression of transcription factors and intermediate filament proteins whose expression is known to be modulated during erythroid differentiation in K562 cells.
  • Metabolomic analysis, conducted to gain insight into intermediary metabolic pathways that ME2 knockdown might affect, showed that ME2 depletion resulted in high orotate levels, suggesting potential impairment of pyrimidine metabolism.
  • Collectively our data point to ME2 as a potentially novel metabolic target for leukemia therapy.

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  • (PMID = 20824065.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / K01 CA104700; United States / NIDDK NIH HHS / DK / T32 DK007199; United States / NCI NIH HHS / CA / K01-CA 104700
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.1.1.37 / Malate Dehydrogenase; EC 1.1.1.37 / malic enzyme 2; human
  • [Other-IDs] NLM/ PMC2932743
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8. Kowalska K, Soscia C, Combe H, Vasseur P, Voulhoux R, Filloux A: The C-terminal amphipathic alpha-helix of Pseudomonas aeruginosa PelC outer membrane protein is required for its function. Biochimie; 2010 Jan;92(1):33-40
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  • Biofilm formation results from the production of a matrix mainly comprised of exopolysaccharides. P. aeruginosa possesses several gene clusters which contribute to the formation of the matrix, including the pel genes.
  • Among the pel genes, pelC encodes an outer membrane protein, which may serve as a transporter of polysaccharide to the bacterial cell surface.

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  • [Copyright] 2009 Elsevier Masson SAS. All rights reserved.
  • (PMID = 19853003.001).
  • [ISSN] 1638-6183
  • [Journal-full-title] Biochimie
  • [ISO-abbreviation] Biochimie
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Bacterial Outer Membrane Proteins
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9. Zhang K, Han W, Zhang R, Xu X, Pan Q, Hu X: Phenylobacterium zucineum sp. nov., a facultative intracellular bacterium isolated from a human erythroleukemia cell line K562. Syst Appl Microbiol; 2007 Apr;30(3):207-12
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  • [Title] Phenylobacterium zucineum sp. nov., a facultative intracellular bacterium isolated from a human erythroleukemia cell line K562.
  • A bacterial strain HLK1(T) was isolated from the human erythroleukemia cell line K562.
  • The type strain is HLK1(T) (=CGMCC 1.3786(T), DSM=18354).

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  • (PMID = 16908113.001).
  • [ISSN] 0723-2020
  • [Journal-full-title] Systematic and applied microbiology
  • [ISO-abbreviation] Syst. Appl. Microbiol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ AY628697/ DQ311665/ DQ311666
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Bacterial; 0 / DNA, Ribosomal; 0 / RNA, Ribosomal, 16S; EC 5.99.1.3 / DNA Gyrase
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10. Abe K, Shimizu R, Pan X, Hamada H, Yoshikawa H, Yamamoto M: Stem cells of GATA1-related leukemia undergo pernicious changes after 5-fluorouracil treatment. Exp Hematol; 2009 Apr;37(4):435-445.e1
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  • [Title] Stem cells of GATA1-related leukemia undergo pernicious changes after 5-fluorouracil treatment.
  • In Gata1.05 gene knockdown mice, Gata1 expression deteriorates to 5% of wild-type allelic expression, a level insufficient for supporting normal erythropoiesis and one that leads to accumulation of erythroid progenitors that are readily transformed into erythroblastic leukemia.
  • To delineate characteristics of leukemic stem cells (LSCs), we analyzed LSCs of Gata1.05 leukemia, which have a potential to reestablish leukemia in mice.
  • MATERIALS AND METHODS: Leukemic cells isolated from the first recipient mice of Gata1.05 leukemia cells were divided into two fractions using Hoechst dye.
  • Fractionated cells were transplanted into second recipient, or analyzed gene expression profiles and cell-cycle status.
  • However, expression of hematopoietic stem cell (HSC)-related genes was upregulated in the LSP cells.
  • CONCLUSION: Based on this observation, distinct self-renewal regulatory mechanisms in LSCs may be considered as one of the causes of worsening of the features of leukemia after injury and relapse.
  • [MeSH-major] Fluorouracil / pharmacology. GATA1 Transcription Factor / metabolism. Leukemia / drug therapy. Stem Cells / drug effects

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  • (PMID = 19302918.001).
  • [ISSN] 1873-2399
  • [Journal-full-title] Experimental hematology
  • [ISO-abbreviation] Exp. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / GATA1 Transcription Factor; 0 / Gata1 protein, mouse; U3P01618RT / Fluorouracil
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11. Garaci E, Favalli C, Pica F, Sinibaldi Vallebona P, Palamara AT, Matteucci C, Pierimarchi P, Serafino A, Mastino A, Bistoni F, Romani L, Rasi G: Thymosin alpha 1: from bench to bedside. Ann N Y Acad Sci; 2007 Sep;1112:225-34
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  • After the initial dramatic effects, observed in a Lewis lung carcinoma animal model, using a combination of thymosin alpha 1 (Talpha1) and interferon (IFN) after cyclophosphamide, a number of other preclinical models in mice (Friend erythroleukemia and B16 melanoma) and in rats (DHD/K12 colorectal cancer liver metastasis) have confirmed the efficacy of the combination therapy with Talpha1 and either IFN or IL-2 plus chemotherapy.
  • [MeSH-minor] Animals. Antineoplastic Agents / therapeutic use. CD4-Positive T-Lymphocytes / drug effects. CD4-Positive T-Lymphocytes / immunology. CD8-Positive T-Lymphocytes / drug effects. CD8-Positive T-Lymphocytes / immunology. Disease Models, Animal. Killer Cells, Natural / drug effects. Killer Cells, Natural / immunology. Mice. Rats

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  • (PMID = 17600290.001).
  • [ISSN] 0077-8923
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / thymalfasin; 61512-21-8 / Thymosin
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12. Talasz H, Lindner HH, Sarg B, Helliger W: Histone H4-lysine 20 monomethylation is increased in promoter and coding regions of active genes and correlates with hyperacetylation. J Biol Chem; 2005 Nov 18;280(46):38814-22
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  • [Title] Histone H4-lysine 20 monomethylation is increased in promoter and coding regions of active genes and correlates with hyperacetylation.
  • In the case of H3-Lys(4), H3-Lys(9), H3-Lys(27), and H4-Lys(20), the degree of methylation was variable from the mono- to the di- or trimethylated state, each of which was presumed to be involved in the organization of chromatin and the activation or repression of genes.
  • Here we investigated the interplay between histone H4-Lys(20) mono- and trim-ethylation and H4 acetylation at induced (beta-major/beta-minor glo-bin), repressed (c-myc), and silent (embryonic beta-globin) genes during in vitro differentiation of mouse erythroleukemia cells.
  • By using chromatin immunoprecipitation, we found that the beta-major and beta-minor promoter and the beta-globin coding regions as well as the promoter and the transcribed exon 2 regions of the highly expressed c-myc gene were hyperacetylated and monomethylated at H4-Lys(20).
  • Although activation of the beta-globin gene resulted in an increase in hyperacetylated, monomethylated H4, down-regulation of the c-myc gene did not cause a decrease in hyperacetylated, monomethylated H4-Lys(20), thus showing a stable pattern of histone modifications.

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  • (PMID = 16166085.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Butyrates; 0 / Chromatin; 0 / Cross-Linking Reagents; 0 / Heterochromatin; 0 / Histones; 0 / Isobutyrates; 0 / Proto-Oncogene Proteins c-myc; 1HG84L3525 / Formaldehyde; 8LL210O1U0 / isobutyric acid; 9004-22-2 / Globins; K3Z4F929H6 / Lysine
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13. Cohen R, Steinmaus C, Quinlan P, Ku R, Cooper M, Roberts T: Development of permissible exposure limits: the California experience. Int J Occup Environ Health; 2006 Jul-Sep;12(3):242-7
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  • [Title] Development of permissible exposure limits: the California experience.
  • The California OSHA Airborne Contaminant Advisory Committee reviewed several hundred substances and recommended occupational exposure limits with the intent of worker and employer protection.
  • [MeSH-major] Advisory Committees / organization & administration. Hazardous Substances / standards. Occupational Exposure / standards. Occupational Health / legislation & jurisprudence
  • [MeSH-minor] Animals. California. Communication. Humans. Maximum Allowable Concentration. National Institute for Occupational Safety and Health (U.S.) / standards. No-Observed-Adverse-Effect Level. Program Development. United States

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  • (PMID = 16967831.001).
  • [ISSN] 1077-3525
  • [Journal-full-title] International journal of occupational and environmental health
  • [ISO-abbreviation] Int J Occup Environ Health
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hazardous Substances
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1
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4. Otsuka Y, Ito D, Katsuoka K, Arashiki N, Komatsu T, Inaba M: Expression of alpha-hemoglobin stabilizing protein and cellular prion protein in a subclone of murine erythroleukemia cell line MEL. Jpn J Vet Res; 2008 Aug;56(2):75-84
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  • [Title] Expression of alpha-hemoglobin stabilizing protein and cellular prion protein in a subclone of murine erythroleukemia cell line MEL.
  • Alpha-Hemoglobin stabilizing protein (AHSP) functions as the erythroid-specific molecular chaperon for alpha-globin.
  • AHSP gene expression has been reported to be downregulated in hematopoietic tissues of animals suffering from prion diseases though the mechanism remains to be clarified.
  • Herein, we demonstrate that MELhipod8 cells, a subclone of murine erythroleukemia (MEL) cells, have prion protein (PrPc) on the cell surface and have highly inducible expression of the AHSP and alpha- and beta-globin genes, resembling the expression pattern of the PrP and AHSP genes in bipotential erythroid- and megakaryocyte-lineage cells followed by erythroid differentiation in normal erythropoiesis.
  • Moreover, MELhipod8 cells exhibit greater effective erythroid differentiation with a population of hemoglobinized normoblast-like cells than that observed for the parental MEL cells.
  • These findings suggest that MELhipod8 cells could provide a mechanism for downregulation of the AHSP gene in prion diseases.
  • [MeSH-minor] Animals. Cell Line, Tumor. Gene Expression Regulation. Leukemia, Erythroblastic, Acute. Mice. Time Factors

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  • (PMID = 18828445.001).
  • [ISSN] 0047-1917
  • [Journal-full-title] The Japanese journal of veterinary research
  • [ISO-abbreviation] Jpn. J. Vet. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Ahsp protein, mouse; 0 / Blood Proteins; 0 / Molecular Chaperones; 0 / PrPC Proteins
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15. Azzini E, Vitaglione P, Intorre F, Napolitano A, Durazzo A, Foddai MS, Fumagalli A, Catasta G, Rossi L, Venneria E, Raguzzini A, Palomba L, Fogliano V, Maiani G: Bioavailability of strawberry antioxidants in human subjects. Br J Nutr; 2010 Oct;104(8):1165-73
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  • No quercetin and ACN were found in plasma, while coumaric acid, 4-hydroxybenzoic acid (4HBA, 56 and 54% of pelargonidin-3-glucoside (Pel-glc) ingested with FS and SS, respectively) and protocatechuic acid (59 and 34% of cyanidin-3-glucoside ingested with FS and SS, respectively) over 8 h from strawberry consumption were retrieved in the plasma.
  • Pelargonidin glucuronide, pelargonidin glucoside and pelargonidin aglycone peaked in urine within 2 h of strawberry consumption, and the 24 h amount excreted was always approximately 0.9% of the Pel-glc dose ingested.
  • Furthermore, in the present study, the metabolism of Pel-glc was elucidated, and, for the first time, 4HBA was suggested to be a major human metabolite of Pel-glc.

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  • (PMID = 20487578.001).
  • [ISSN] 1475-2662
  • [Journal-full-title] The British journal of nutrition
  • [ISO-abbreviation] Br. J. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anthocyanins; 0 / Antioxidants; 0 / Phenols; 36-88-4 / Carotenoids; 45XWE1Z69V / alpha-carotene
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16. Hancock D, Funnell A, Jack B, Johnston J: Introducing undergraduate students to real-time PCR. Biochem Mol Biol Educ; 2010 Sep;38(5):309-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The model used is a murine erythroleukemia cell line (MEL cells).
  • These continuously cycling, immature red blood cells, arrested at an early stage in erythropoiesis, can be induced to progress further through the process by 72 h exposure to 1.8% DMSO.
  • The relative levels of three sequences: β globin, amino levulinate synthase, and carbonic anhydrase-1 are estimated by real-time PCR, using 18S rRNA as the reference sequence.
  • The changes in gene expression are robust and reproducible, enabling students to experience a "cutting edge" research technique in an undergraduate lab setting.
  • While the undergraduate student experience in practical classes with such sensitive techniques is often mixed, the changes in gene expression in this model are sufficiently great that students can gain the satisfaction of consistent results.

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  • [Copyright] Copyright © 2010 International Union of Biochemistry and Molecular Biology, Inc.
  • (PMID = 21567850.001).
  • [ISSN] 1539-3429
  • [Journal-full-title] Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology
  • [ISO-abbreviation] Biochem Mol Biol Educ
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Patnayak R, Paul TR, Uppin SG, K G, Rajappa S, Rao DR: Acute erythroid leukemia (AML-M6) - Is it rare? Turk J Haematol; 2009 Mar 5;26(1):38-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acute erythroid leukemia (AML-M6) - Is it rare?

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  • (PMID = 27265109.001).
  • [ISSN] 1300-7777
  • [Journal-full-title] Turkish journal of haematology : official journal of Turkish Society of Haematology
  • [ISO-abbreviation] Turk J Haematol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
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18. Das KC, Das M, Mohanty D, Jadaon MM, Gupta A, Marouf R, Easow SK: Megaloblastosis: from morphos to molecules. Med Princ Pract; 2005;14 Suppl 1:2-14
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  • OBJECTIVE: Megaloblastosis (i.e., megaloblastic transformation of erythroid precursor cells in the bone marrow) is the cytomorphological hallmark of megaloblastic anemia resulting from vitamin B12 and folate deficiency.
  • RESULTS: Derangement of DNA synthesis occurred due to an impaired de novo pathway of thymidylate synthesis in both vitamin-B12- and folate-deficient human megaloblastic bone marrows as well as in the bone marrows of rhesus monkeys and rats with experimentally induced folate deficiency.
  • On the other hand, megaloblastic changes in the bone marrow of human patients with myelodysplastic syndrome and erythroleukemia were not associated with this DNA synthetic abnormality.

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  • [Copyright] Copyright 2005 S. Karger AG, Basel
  • (PMID = 16103708.001).
  • [ISSN] 1011-7571
  • [Journal-full-title] Medical principles and practice : international journal of the Kuwait University, Health Science Centre
  • [ISO-abbreviation] Med Princ Pract
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Genetic Markers; 0 / Histones; 9007-49-2 / DNA
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19. Moreau-Gachelin F: Multi-stage Friend murine erythroleukemia: molecular insights into oncogenic cooperation. Retrovirology; 2008;5:99
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  • [Title] Multi-stage Friend murine erythroleukemia: molecular insights into oncogenic cooperation.
  • The Friend virus SFFV (Spleen Focus Forming Virus) provokes an acute erythroblastosis in susceptible strains of mice that progresses to overt erythroleukemia by a multi-step process.
  • For virologists, the Friend virus-induced disease has provided deep insights into the host mechanisms influencing susceptibility to retroviral infection and viremia.
  • For cell biologists and oncologists, this leukemia has been a powerful experimental model to identify critical oncogenes involved in a multi-stage process, to understand the contribution of host genes to cancer development, and to investigate the mechanisms leading to cell growth autonomy.
  • This model also provided an example of oncogenic reversion since Friend tumor cells can reinitiate their erythroid differentiation program when exposed in vitro to some chemical inducers.
  • The Friend model of leukemia progression recapitulates the two phases of human acute myeloid leukemia (AML).
  • Coupling of insights from studies on the Friend erythroleukemia with knowledge on AML might allow a better understanding of the molecular mechanisms involved in the evolution of leukemia in mice and men.
  • [MeSH-major] Cell Transformation, Neoplastic. Leukemia, Erythroblastic, Acute / virology. Oncogenes. Spleen Focus-Forming Viruses / pathogenicity
  • [MeSH-minor] Animals. Animals, Newborn. Cell Differentiation. Cell Proliferation. Humans. Leukemia, Myeloid, Acute / pathology. Male. Mice

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  • (PMID = 18983647.001).
  • [ISSN] 1742-4690
  • [Journal-full-title] Retrovirology
  • [ISO-abbreviation] Retrovirology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 132
  • [Other-IDs] NLM/ PMC2585586
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20. Herchel R, Sindelár Z, Trávnícek Z, Zboril R, Vanco J: Novel 1D chain Fe(III)-salen-like complexes involving anionic heterocyclic N-donor ligands. Synthesis, X-ray structure, magnetic, (57)Fe Mössbauer, and biological activity studies. Dalton Trans; 2009 Nov 28;(44):9870-80
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  • The iron(III) salen-type complexes [Fe(salen)(L)](n) (1-6) involving heterocyclic N-donor ligands HL {HL = 1H-imidazole (Himz), 1H-tetrazol-5-amine (Hatz), 5-methyl-1H-tetrazole (Hmtz), 1H-benzimidazole (Hbimz), 1H-1,2,4-triazole (Htriz) and 1H-benzotriazole (Hbtriz)} have been prepared and characterised by elemental analysis, FT IR, CI mass and (57)Fe Mössbauer spectroscopies, and variable temperature magnetic measurements.
  • The compounds have been tested for their SOD-like activity, DNA cleavage activity, and in vitro cytotoxicity against two human cancer cell lines: chronic myelogenous erythroleukemia (K562) and breast adenocarcinoma (MCF7).
  • [MeSH-minor] Adenocarcinoma / metabolism. Breast Neoplasms / metabolism. Cell Line, Tumor. Crystallography, X-Ray. DNA Cleavage. Humans. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism. Ligands. Spectroscopy, Mossbauer. Superoxide Dismutase / pharmacology

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  • (PMID = 19885536.001).
  • [ISSN] 1477-9234
  • [Journal-full-title] Dalton transactions (Cambridge, England : 2003)
  • [ISO-abbreviation] Dalton Trans
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Ferric Compounds; 0 / Ligands; E1UOL152H7 / Iron; EC 1.15.1.1 / Superoxide Dismutase
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21. Drobot L, Husak Z, Ilnytska O, Igumentseva N, Oleksyn H, Kusen' S: Transient activation of Ras-dependent signalling at the early stages of Herbimycin A induced erythroid differentiation of human K562 cells. Exp Oncol; 2005 Mar;27(1):31-7
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  • [Title] Transient activation of Ras-dependent signalling at the early stages of Herbimycin A induced erythroid differentiation of human K562 cells.
  • AIM: To study the dynamics of Ras-dependent signalling in the course of Herbimycin A induced erythroid differentiation of human erythroleukemia K562 cells.
  • Transient rise of Ras-GTP level at 3rd h of incubation in the presence of Herbimycin A correlated with the increase in tyrosine phosphorylation of proteins with apparent molecular weight of 210, 160, 140, 116 and 42 kDa, as well as with the activation of Erk2 and increase of binding of a set of pY-containing proteins with recombinant GST-fusion form of Ras activator, adaptor protein Grb2.
  • CONCLUSION: The obtained results suggest that time-dependent changes in Grb2-mediated network of protein-protein interaction events might define implication of Ras-dependent signalling in Herbimycin A-induced erythroid differentiation of K562 cells.
  • [MeSH-major] Enzyme Inhibitors / pharmacology. Erythroid Cells / cytology. Proto-Oncogene Proteins p21(ras) / metabolism. Quinones / pharmacology. Signal Transduction / physiology

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  • (PMID = 15812354.001).
  • [ISSN] 1812-9269
  • [Journal-full-title] Experimental oncology
  • [ISO-abbreviation] Exp. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ukraine
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Benzoquinones; 0 / Enzyme Inhibitors; 0 / GRB2 Adaptor Protein; 0 / GRB2 protein, human; 0 / Lactams, Macrocyclic; 0 / Quinones; 146-91-8 / Guanosine Diphosphate; 1W306TDA6S / Rifabutin; 42HK56048U / Tyrosine; 70563-58-5 / herbimycin; 86-01-1 / Guanosine Triphosphate; EC 2.5.1.18 / Glutathione Transferase; EC 3.6.5.2 / HRAS protein, human; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras)
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22. Karsten U, Butschak G, Stahn R, Goletz S: A novel series of anti-human glycophorin A (CD235a) antibodies defining five extra- and intracellular epitopes. Int Immunopharmacol; 2010 Nov;10(11):1354-60
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  • Glycophorin A (GPA, CD235a) is a major membrane glycoprotein and marker of cells of the erythroid lineage.
  • The new panel complements the already known anti-glycophorin antibodies and offers several potential applications for, e.g., differential diagnosis of erythroleukemias, lineage analyses of erythroid cells, isolation of senescent erythrocytes, or a highly sensitive neuraminidase assay.

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  • [Copyright] Copyright © 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20727998.001).
  • [ISSN] 1878-1705
  • [Journal-full-title] International immunopharmacology
  • [ISO-abbreviation] Int. Immunopharmacol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Epitopes; 0 / Glycophorin; 0 / Sialoglycoproteins; EC 3.2.1.18 / Neuraminidase
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23. Lesage J, Stanley J, Karoly WJ, Lichtenberg FW: Airborne methylene diphenyl diisocyanate (MDI) concentrations associated with the application of polyurethane spray foam in residential construction. J Occup Environ Hyg; 2007 Feb;4(2):145-55
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  • Spray foam applicators and assistants may be exposed to airborne MDI concentrations above the OSHA permissible exposure limit.
  • At these concentrations, OSHA recommends appropriate respiratory protection during spray foam application to prevent airborne MDI exposures above established limits and to protect against exposure to dichlorofluoroethane (HCFC-141b).
  • After 45 min, airborne concentrations were below the limit of quantitation (LOQ) of 0.036-microg per sample.
  • [MeSH-major] Air Pollutants, Occupational / analysis. Chlorofluorocarbons / analysis. Isocyanates / analysis. Occupational Exposure / analysis. Polyurethanes
  • [MeSH-minor] Canada. Chlorofluorocarbons, Ethane. Facility Design and Construction. Housing. Humans. Particle Size. Threshold Limit Values. United States

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  • (PMID = 17249149.001).
  • [ISSN] 1545-9624
  • [Journal-full-title] Journal of occupational and environmental hygiene
  • [ISO-abbreviation] J Occup Environ Hyg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Air Pollutants, Occupational; 0 / Chlorofluorocarbons; 0 / Chlorofluorocarbons, Ethane; 0 / Isocyanates; 0 / Polyurethanes; 101-68-8 / 4,4'-diphenylmethane diisocyanate; 1717-00-6 / 1,1-dichloro-1-fluoroethane; 9009-54-5 / polyurethane foam
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24. Nadali F, Pourfathollah AA, Alimoghaddam K, Nikougoftar M, Rostami S, Dizaji A, Azizi E, Zomorodipour A, Ghavamzadeh A: Multidrug resistance inhibition by antisense oligonucleotide against MDR1/mRNA in P-glycoprotein expressing leukemic cells. Hematology; 2007 Oct;12(5):393-401
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  • INTRODUCTION: Acute myeloblastic leukemia (AML) is the most common form of acute leukemia in adults.
  • One major problem in this disease is the emergence of leukemic blast cells that are resistant to anticancer drugs.
  • One cause of MDR is the expression of the MDR1 gene and its product, P-glycoprotein (Pgp).
  • MATERIALS AND METHODS: The Pgp expressing cell line was established from a parental K562 (Erythroleukemia) cell line with increasing concentrations of doxorubicin, and named KDI/20.
  • The effect of PS-ODN was assessed at the cellular level by flow cytometry (for Pgp detection), and Rhodamine 123 assay (for functional assessment of Pgp) at the molecular level by RT-PCR (for MDR1/mRNA detection) and MTT assay in order to assess the sensitivity of cell to doxorubicin.
  • Therefore, our data showed that antisense can reverse the MDR phenotype at the transcription level and the PEI vector is more efficient than cationic lipid.
  • [MeSH-major] Drug Resistance, Multiple / drug effects. Leukemia / drug therapy. Oligonucleotides, Antisense / pharmacology. P-Glycoprotein / drug effects. RNA, Messenger / drug effects

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  • (PMID = 17852455.001).
  • [ISSN] 1607-8454
  • [Journal-full-title] Hematology (Amsterdam, Netherlands)
  • [ISO-abbreviation] Hematology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / ABCB1 protein, human; 0 / Oligonucleotides; 0 / Oligonucleotides, Antisense; 0 / P-Glycoprotein; 0 / P-Glycoproteins; 0 / RNA, Messenger; 0 / Thionucleotides; 80168379AG / Doxorubicin
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25. Tan PK, Wang J, Littler PL, Wong KK, Sweetnam TA, Keefe W, Nash NR, Reding EC, Piu F, Brann MR, Schiffer HH: Monitoring interactions between receptor tyrosine kinases and their downstream effector proteins in living cells using bioluminescence resonance energy transfer. Mol Pharmacol; 2007 Dec;72(6):1440-6
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  • A total of 22 BRET assays have been established for nine RTKs derived from four subfamilies [erythroblastic leukemia viral (v-erb-b) oncogene homolog (ErbB), platelet-derived growth factor (PDGF), neurotrophic tyrosine kinase receptor (TRK), vascular endothelial growth factor (VEGF)] monitoring the interactions with five effectors (Grb2, p85, Stat5a, Shc46, PLCgamma1).
  • RTK BRET assays are highly sensitive for quantifying ligand-independent (constitutive), agonist-induced, or antagonist-inhibited RTK activity levels.


26. Selga E, Oleaga C, Ramírez S, de Almagro MC, Noé V, Ciudad CJ: Networking of differentially expressed genes in human cancer cells resistant to methotrexate. Genome Med; 2009;1(9):83
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  • [Title] Networking of differentially expressed genes in human cancer cells resistant to methotrexate.
  • These are especially useful to rationalize how external perturbations propagate through the expression of genes.
  • To address this issue in the case of drug resistance, we constructed biological association networks of genes differentially expressed in cell lines resistant to methotrexate (MTX).
  • METHODS: Seven cell lines representative of different types of cancer, including colon cancer (HT29 and Caco2), breast cancer (MCF-7 and MDA-MB-468), pancreatic cancer (MIA PaCa-2), erythroblastic leukemia (K562) and osteosarcoma (Saos-2), were used.
  • Genes deregulated in common between the different cancer cell lines served to generate biological association networks using the Pathway Architect software.
  • RESULTS: Dikkopf homolog-1 (DKK1) is a highly interconnected node in the network generated with genes in common between the two colon cancer cell lines, and functional validations of this target using small interfering RNAs (siRNAs) showed a chemosensitization toward MTX.
  • Members of the UDP-glucuronosyltransferase 1A (UGT1A) family formed a network of genes differentially expressed in the two breast cancer cell lines. siRNA treatment against UGT1A also showed an increase in MTX sensitivity.
  • Eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) was overexpressed among the pancreatic cancer, leukemia and osteosarcoma cell lines, and siRNA treatment against EEF1A1 produced a chemosensitization toward MTX.
  • CONCLUSIONS: Biological association networks identified DKK1, UGT1As and EEF1A1 as important gene nodes in MTX-resistance.
  • Treatments using siRNA technology against these three genes showed chemosensitization toward MTX.

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  • (PMID = 19732436.001).
  • [ISSN] 1756-994X
  • [Journal-full-title] Genome medicine
  • [ISO-abbreviation] Genome Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2768990
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27. Palusa SG, Golovkin M, Shin SB, Richardson DN, Reddy AS: Organ-specific, developmental, hormonal and stress regulation of expression of putative pectate lyase genes in Arabidopsis. New Phytol; 2007;174(3):537-50
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  • [Title] Organ-specific, developmental, hormonal and stress regulation of expression of putative pectate lyase genes in Arabidopsis.
  • Pectate lyases catalyse the eliminative cleavage of de-esterified homogalacturonan in pectin, a major component of the primary cell walls in higher plants.
  • In the completed genome of Arabidopsis, there are 26 genes (AtPLLs) that encode pectate lyase-like proteins.
  • Interestingly, all PLL genes are expressed in flowers.
  • Analysis of expression of all PLL genes in seedlings treated with hormones, abiotic stresses and elicitors of defense responses revealed significant changes in the expression of some PLLs without affecting the other PLLs.
  • The stability of transcripts of PLLs varied considerably among different genes.
  • [MeSH-major] Arabidopsis / genetics. Arabidopsis Proteins / genetics. Gene Expression Regulation, Plant. Polysaccharide-Lyases / genetics

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  • (PMID = 17447910.001).
  • [ISSN] 0028-646X
  • [Journal-full-title] The New phytologist
  • [ISO-abbreviation] New Phytol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Arabidopsis Proteins; 0 / Deoxyadenosines; 0 / RNA, Messenger; 73-03-0 / cordycepin; EC 4.2.2.- / Polysaccharide-Lyases; EC 4.2.2.2 / pectate lyase
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28. De Filippi R, Iaccarino G, Frigeri F, Di Francia R, Crisci S, Capobianco G, Arcamone M, Becchimanzi C, Amoroso B, De Chiara A, Corazzelli G, Pinto A: Elevation of clonal serum free light chains in patients with HIV-negative primary effusion lymphoma (PEL) and PEL-like lymphoma. Br J Haematol; 2009 Nov;147(3):405-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Elevation of clonal serum free light chains in patients with HIV-negative primary effusion lymphoma (PEL) and PEL-like lymphoma.

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  • (PMID = 19681885.001).
  • [ISSN] 1365-2141
  • [Journal-full-title] British journal of haematology
  • [ISO-abbreviation] Br. J. Haematol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Immunoglobulin Light Chains
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29. Xu R, Shi X, Zhang W, Xu Y, Tian Z, Lu X, Han X, Bao X: Cooperative structure-directing effect in the synthesis of aluminophosphate molecular sieves in ionic liquids. Phys Chem Chem Phys; 2010 Mar 14;12(10):2443-9
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  • Combining with the characterizations of the solid products by solid-state NMR, it is verified that different aggregates of organic amines with imidazolium cations, which is similar to self-assembled supramolecular analogues, could act as the structure-directing agents for selective tuning of the framework topologies such as AEL, AFI and LTA in the final solid products.

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  • (PMID = 20449358.001).
  • [ISSN] 1463-9084
  • [Journal-full-title] Physical chemistry chemical physics : PCCP
  • [ISO-abbreviation] Phys Chem Chem Phys
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Aluminum Compounds; 0 / Ionic Liquids; 0 / Phosphates; F92V3S521O / aluminum phosphate
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30. Prokhorova TA, Rigbolt KT, Johansen PT, Henningsen J, Kratchmarova I, Kassem M, Blagoev B: Stable isotope labeling by amino acids in cell culture (SILAC) and quantitative comparison of the membrane proteomes of self-renewing and differentiating human embryonic stem cells. Mol Cell Proteomics; 2009 May;8(5):959-70
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  • Of the 811 identified membrane proteins, six displayed significantly higher expression levels in the undifferentiated state compared with differentiating cells.
  • This group includes the established marker CD133/Prominin-1 as well as novel candidates for hESC surface markers: Glypican-4, Neuroligin-4, ErbB2, receptor-type tyrosine-protein phosphatase zeta (PTPRZ), and Glycoprotein M6B.
  • Our study also revealed 17 potential markers of hESC differentiation as their corresponding protein expression levels displayed a dramatic increase in differentiated embryonic stem cell populations.
  • [MeSH-minor] Animals. Biomarkers / metabolism. Cell Proliferation. Cells, Cultured. Culture Media, Conditioned. Gene Expression Regulation, Developmental. Humans. Mice. Phosphoproteins / analysis. Pluripotent Stem Cells / cytology. Proteomics. RNA, Messenger / genetics. RNA, Messenger / metabolism

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  • (PMID = 19151416.001).
  • [ISSN] 1535-9484
  • [Journal-full-title] Molecular & cellular proteomics : MCP
  • [ISO-abbreviation] Mol. Cell Proteomics
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amino Acids; 0 / Biomarkers; 0 / Culture Media, Conditioned; 0 / Membrane Proteins; 0 / Phosphoproteins; 0 / Proteome; 0 / RNA, Messenger
  • [Other-IDs] NLM/ PMC2689770
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31. Jost PJ, Ruland J: Aberrant NF-kappaB signaling in lymphoma: mechanisms, consequences, and therapeutic implications. Blood; 2007 Apr 1;109(7):2700-7
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  • However, constitutive NF-kappaB activation can promote continuous lymphocyte proliferation and survival and has recently been recognized as a critical pathogenetic factor in lymphoma.
  • Various molecular events lead to deregulation of NF-kappaB signaling in Hodgkin disease and a variety of T- and B-cell non-Hodgkin lymphomas either up-stream or downstream of the central IkappaB kinase.
  • This review provides an overview of the NF-kappaB pathway and discusses the mechanisms of NF-kappaB deregulation in distinct lymphoma entities with defined aberrant pathways: Hodgkin lymphoma (HL), diffuse large B-cell lymphoma (DLBCL), mucosa-associated lymphoid tissue (MALT) lymphoma, primary effusion lymphoma (PEL), and adult T-cell lymphoma/leukemia (ATL).
  • [MeSH-minor] Hodgkin Disease / physiopathology. Humans. Leukemia-Lymphoma, Adult T-Cell / physiopathology. Lymphocytes / physiology. Lymphoma, B-Cell / physiopathology. Lymphoma, B-Cell, Marginal Zone / genetics. Lymphoma, B-Cell, Marginal Zone / physiopathology. Lymphoma, Large B-Cell, Diffuse / physiopathology. Models, Biological. Oncogene Proteins, Viral / physiology. Prognosis. Signal Transduction / physiology. Translocation, Genetic

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  • (PMID = 17119127.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / NF-kappa B; 0 / Oncogene Proteins, Viral
  • [Number-of-references] 96
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32. Küçükkaya B, Oztürk G, Yalçintepe L: Nitric oxide levels during erythroid differentiation in K562 cell line. Indian J Biochem Biophys; 2006 Aug;43(4):251-3
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  • [Title] Nitric oxide levels during erythroid differentiation in K562 cell line.
  • This study was designed to investigate the possible role of NO during erythroid differentiation in K562 erythroleukemia cells.
  • The chronic myelogenous leukemia (K562) cell line can be triggered in culture to differentiate along the erythrocytic pathway, in response to a variety of stimulatory agents.
  • We investigated NOx (nitrate+nitrite) levels in uninduced (control) and hemin-induced K562 cell lysates during erythroid differentiation.
  • Our results showed that NO levels decreased significantly on fourth and sixth day both in hemin-induced and control cells; the decrease was, however, more in hemin-induced group than in control group.

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  • (PMID = 17133771.001).
  • [ISSN] 0301-1208
  • [Journal-full-title] Indian journal of biochemistry & biophysics
  • [ISO-abbreviation] Indian J. Biochem. Biophys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Hemoglobins; 0 / Nitrates; 0 / Nitrites; 31C4KY9ESH / Nitric Oxide; 743LRP9S7N / Hemin
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33. Towata T, Komizu Y, Suzu S, Ueoka R, Okada S: Highly selective fusion and accumulation of hybrid liposomes into primary effusion lymphoma cells along with induction of apoptosis. Biochem Biophys Res Commun; 2010 Mar 12;393(3):445-8
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  • Primary effusion lymphoma (PEL) is an aggressive neoplasm caused by human herpes virus-8 infection, and is generally resistant to chemotherapy.
  • Hybrid liposomes, composed of dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene (21) dodecyl ether (C12(EO)21) (HL-21), were rapidly accumulated in the membrane of PEL cells.
  • HL-21 also increased membrane fluidity of PEL cells, and induced caspase-3 activation along with cell death.
  • These results suggest that HL-21 should be an effective and attractive regent for PEL treatment.

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  • [Copyright] 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20138834.001).
  • [ISSN] 1090-2104
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Liposomes; 0AWH8BFG9A / polidocanol; 30IQX730WE / Polyethylene Glycols; U86ZGC74V5 / Dimyristoylphosphatidylcholine
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34. Simonelli C, Tedeschi R, Gloghini A, Bortolin MT, Spina M, Bidoli E, Cinelli R, De Paoli P, Carbone A, Tirelli U: Characterization of immunologic and virological parameters in HIV-infected patients with primary effusion lymphoma during antiblastic therapy and highly active antiretroviral therapy. Clin Infect Dis; 2005 Apr 1;40(7):1022-7
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  • BACKGROUND: Primary effusion lymphoma (PEL) represents a peculiar lymphoma infected with human herpesvirus 8 (HHV-8) and occurs predominantly in human immunodeficiency virus (HIV)-infected patients.
  • The aim of the present study was to evaluate the immunologic and virological parameters, including HHV-8 viremia, of 5 HIV-infected patients with PEL whose disease was diagnosed and treated at our institute.
  • Biological parameters, such as latent and lytic HHV-8 antigen levels, plasma HHV-8 load, Epstein-Barr virus plasma DNA load, HIV-1 load, and CD4 cell count, were assessed before treatment, during therapy, and at follow-up.
  • RESULTS: Four patients were treated with chemotherapy and highly active antiretroviral therapy (HAART), and 1 was treated with HAART alone; 3 of 5 patients reached complete remission.
  • HHV-8 levels decreased after therapy in 4 patients.
  • CONCLUSIONS: Our analysis demonstrates that HHV-8 can be detected in the plasma at the onset of PEL; its prognostic role needs to be explored.
  • CD4 cell count seems to be the most important indicator of progression of PEL.
  • [MeSH-minor] Adult. Anti-HIV Agents. CD4 Lymphocyte Count. Disease Progression. Female. Gene Expression Regulation, Viral. Herpesvirus 8, Human. Humans. Male. Viral Load. Viral Proteins / metabolism. Viremia


35. Cui JW, Li YJ, Sarkar A, Brown J, Tan YH, Premyslova M, Michaud C, Iscove N, Wang GJ, Ben-David Y: Retroviral insertional activation of the Fli-3 locus in erythroleukemias encoding a cluster of microRNAs that convert Epo-induced differentiation to proliferation. Blood; 2007 Oct 1;110(7):2631-40
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  • [Title] Retroviral insertional activation of the Fli-3 locus in erythroleukemias encoding a cluster of microRNAs that convert Epo-induced differentiation to proliferation.
  • Friend erythroleukemia has been used as an excellent system for the identification and characterization of oncogenes and tumor suppressor genes involved in neoplastic transformation.
  • Using this model, we have isolated a novel integration site designated Fli-3, from a Friend murine leukemia virus (F-MuLV)-induced erythroleukemia.
  • The Fli-3 transcription unit is a murine homologue of the human gene C13orf25 that includes a region encoding the mir-17-92 miRNA cluster.
  • C13orf25 is the target gene of 13q31 chromosomal amplification in human B-cell lymphomas and other malignancies.
  • The erythroleukemias that have acquired either insertional activation or amplification of Fli-3 express higher levels of the primary or mature miRNAs derived from mir-17-92.
  • The ectopic expression of Fli-3 in an erythroblastic cell line switches erythropoietin (Epo)-induced differentiation to Epo-induced proliferation through activation of the Ras and PI3K pathways.
  • These findings highlight the potential of the Fli-3 encoding mir-17-92 in the development of erythroleukemia and its important role in hematopoiesis.
  • [MeSH-major] Cell Differentiation / drug effects. Erythropoietin / pharmacology. Friend murine leukemia virus / genetics. Leukemia, Erythroblastic, Acute / metabolism. Leukemia, Erythroblastic, Acute / pathology. MicroRNAs / genetics. Viral Proteins / metabolism
  • [MeSH-minor] Animals. Base Sequence. Cell Line. Cell Proliferation / drug effects. Gene Expression Regulation, Neoplastic. Gene Expression Regulation, Viral. Humans. Mice. Multigene Family. Mutagenesis, Insertional / genetics. Transcription, Genetic / genetics

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  • (PMID = 17586726.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MicroRNAs; 0 / Viral Proteins; 11096-26-7 / Erythropoietin
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36. Mardini L, Gasiorek J, Derjuga A, Carrière L, Schranzhofer M, Paw BH, Ponka P, Blank V: Antagonistic roles of the ERK and p38 MAPK signalling pathways in globin expression, haem biosynthesis and iron uptake. Biochem J; 2010 Nov 15;432(1):145-51
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  • Late-stage erythroid cells synthesize large quantities of haemoglobin, a process requiring the co-ordinated regulation of globin and haem synthesis as well as iron uptake.
  • In the present study, we investigated the role of the ERK (extracellular-signal-regulated kinase) and p38 MAPK (mitogen-activated protein kinase) signalling pathways in MEL (mouse erythroleukaemia) cell differentiation.
  • We found that treatment of HMBA (hexamethylene bisacetamide)-induced MEL cells with the ERK pathway inhibitor UO126 results in an increase in intracellular haem and haemoglobin levels.
  • The transcript levels of the genes coding for β(major)-globin, the haem biosynthesis enzyme 5-aminolevulinate synthase 2 and the mitochondrial iron transporter mitoferrin 1 are up-regulated.
  • Reporter assays showed that globin promoter and HS2 enhancer-mediated transcription was under the control of MAPKs, as inhibition of the ERK and p38 MAPK pathways led to increased and decreased gene activity respectively.
  • Our present results suggest that the ERK1/2 and p38α/β MAPKs play antagonistic roles in HMBA-induced globin gene expression and erythroid differentiation.
  • These results provide a novel link between MAPK signalling and the regulation of haem biosynthesis and iron uptake in erythroid cells.

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  • (PMID = 20738258.001).
  • [ISSN] 1470-8728
  • [Journal-full-title] The Biochemical journal
  • [ISO-abbreviation] Biochem. J.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / P01 HL032262; United States / NIDDK NIH HHS / DK / R01 DK070838; Canada / Canadian Institutes of Health Research / / MOP-79361
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole; 0 / Acetamides; 0 / Antineoplastic Agents; 0 / Butadienes; 0 / Enzyme Inhibitors; 0 / Hemoglobins; 0 / Imidazoles; 0 / Nitriles; 0 / Pyridines; 0 / U 0126; 42VZT0U6YR / Heme; 9004-22-2 / Globins; E1UOL152H7 / Iron; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3; EC 2.7.11.24 / Mitogen-Activated Protein Kinases; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases; LA133J59VU / hexamethylene bisacetamide
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37. Chen D, Sandford G, Nicholas J: Intracellular signaling mechanisms and activities of human herpesvirus 8 interleukin-6. J Virol; 2009 Jan;83(2):722-33
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  • While vIL-6 is generally considered to be a lytic gene, several reports have noted its low-level expression in latently infected primary effusion lymphoma (PEL) cultures, in the absence of other lytic gene expression.
  • Knockdown of vIL-6 expression in PEL cells led to markedly reduced cell growth in normal culture, independently of extracellular cytokines.

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  • (PMID = 18987143.001).
  • [ISSN] 1098-5514
  • [Journal-full-title] Journal of virology
  • [ISO-abbreviation] J. Virol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA076445; United States / NCI NIH HHS / CA / R01-CA76445
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / IL6R protein, human; 0 / Interleukin-6; 0 / Receptors, Interleukin-6; 0 / Viral Proteins; 0 / interleukin-6, RRV-HHV-8; 133483-10-0 / Cytokine Receptor gp130
  • [Other-IDs] NLM/ PMC2612405
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38. Matsumoto T, Matsubara M, Oana K, Kasuga E, Suzuki T, Hidaka E, Shigemura T, Yamauchi K, Honda T, Ota H, Kawakami Y: First case of bacteremia due to chromosome-encoded CfxA3-beta-lactamase-producing Capnocytophaga sputigena in a pediatric patient with acute erythroblastic leukemia. Eur J Med Res; 2008 Mar 31;13(3):133-5
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  • [Title] First case of bacteremia due to chromosome-encoded CfxA3-beta-lactamase-producing Capnocytophaga sputigena in a pediatric patient with acute erythroblastic leukemia.
  • Bacteremia due to Capnocytophaga sputigena occurred in a 4-year and 9-month-old Japanese girl patient with acute erythroblastic leukemia in Shinshu University Hospital, Japan.
  • The causative Capnocytophaga sputigena isolate was found to be a beta-lactamase-producer demonstrating to possess cfxA3 gene.
  • The gene responsible for the production of CfxA3-beta-lactamase was proved to be chromosome-encoded, by means of southern hybridization analysis.
  • [MeSH-major] Bacteremia / microbiology. Capnocytophaga / isolation & purification. Chromosomes, Bacterial. Leukemia, Erythroblastic, Acute / complications. beta-Lactamases / biosynthesis

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  • (PMID = 18499560.001).
  • [ISSN] 0949-2321
  • [Journal-full-title] European journal of medical research
  • [ISO-abbreviation] Eur. J. Med. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; EC 3.5.2.6 / beta-Lactamases
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39. Tsai YH, Wu MF, Wu YH, Chang SJ, Lin SF, Sharp TV, Wang HW: The M type K15 protein of Kaposi's sarcoma-associated herpesvirus regulates microRNA expression via its SH2-binding motif to induce cell migration and invasion. J Virol; 2009 Jan;83(2):622-32
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  • [Title] The M type K15 protein of Kaposi's sarcoma-associated herpesvirus regulates microRNA expression via its SH2-binding motif to induce cell migration and invasion.
  • The KSHV open reading frame K15 is a KSHV-specific gene encoding a transmembrane protein.
  • The two K15 alleles resemble the latent membrane protein 2A (LMP2A) gene of Epstein-Barr virus (EBV) in their genomic locations and protein topology.
  • K15 therefore appears to be a hybrid of a distant evolutionary relative of EBV LMP1 and LMP2A.
  • In this study, we show that K15M is latently expressed in KSHV-positive PEL cells and knockdown of K15M in PEL cells reduces cell motility.
  • [MeSH-minor] Cell Line, Tumor. Cell Migration Assays. Gene Knockdown Techniques. Humans. Intracellular Membranes / chemistry. Lysosomes / chemistry. NF-kappa B / biosynthesis

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  • (PMID = 18971265.001).
  • [ISSN] 1098-5514
  • [Journal-full-title] Journal of virology
  • [ISO-abbreviation] J. Virol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / K15 protein, Human herpesvirus 8; 0 / MIRN21 microRNA, human; 0 / MIRN31 microRNA, human; 0 / MicroRNAs; 0 / NF-kappa B; 0 / Viral Proteins
  • [Other-IDs] NLM/ PMC2612383
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40. Dykxhoorn DM, Schlehuber LD, London IM, Lieberman J: Determinants of specific RNA interference-mediated silencing of human beta-globin alleles differing by a single nucleotide polymorphism. Proc Natl Acad Sci U S A; 2006 Apr 11;103(15):5953-8
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  • A single nucleotide polymorphism (SNP) in the sickle beta-globin gene (beta(S)) leads to sickle cell anemia.
  • RNA interference (RNAi) uses small interfering (si)RNAs for sequence-specific gene silencing.
  • A beta(S) siRNA with position 10 of the guide strand designed to align with the targeted beta(S) SNP specifically silences beta(S) gene expression without affecting the expression of the gamma-globin or normal beta-globin (beta(A)) genes.
  • Specific beta(S) silencing was demonstrated by using a luciferase reporter and full-length beta(S) cDNA transfected into HeLa cells and mouse erythroleukemia cells, where it was expressed in the context of the endogenous beta-globin gene promoter and the locus control region enhancers.
  • When this strategy was used to target beta(E), silencing was not limited to the mutant gene but also targeted the normal beta(A) gene. siRNAs, mismatched with their target at position 10, guided mRNA cleavage in all cases except when two bulky purines were aligned.
  • The specific silencing of the beta(S)-globin gene, as compared with beta(E), as well as studies of silencing SNP mutants in other diseases, indicates that siRNAs developed to target a disease-causing SNP will be specific if the mutant residue is a pyrimidine and the normal residue is a purine.

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  • (PMID = 16585504.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / 5 T32 HL007556-19; United States / NHLBI NIH HHS / HL / P01 HL 055435-11; United States / NIAID NIH HHS / AI / U19 AI056900; United States / NIAID NIH HHS / AI / AI056900; United States / NHLBI NIH HHS / HL / P01 HL055435; United States / NHLBI NIH HHS / HL / T32 HL007556
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 9004-22-2 / Globins; EC 1.13.12.5 / Luciferases, Renilla
  • [Other-IDs] NLM/ PMC1458679
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41. Di Donato A, Di Giampaolo L, Reale M, Dadorante V, Alparone F, Stocchi M, Fattorini E, Di Gioacchino M, Magrini A, Boscolo P: Effect of occupational stress and anxiety on natural killer lymphocyte activity of men and women employed in a university. Int J Immunopathol Pharmacol; 2006 Oct-Dec;19(4 Suppl):79-84
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  • [Title] Effect of occupational stress and anxiety on natural killer lymphocyte activity of men and women employed in a university.
  • The aim of this study is the immune response of the staff of a university and a museum (referent group).
  • Blood samples were collected for determining NK cytotoxic activity vs human erythroleukaemia cells and the lymphocyte subsets CD45+, CD45+-CD3+, CD45+-CD3+-CD4+, CD45+-CD3+-CD8+, CD45+-CD3-CD8+, CD3+-CD16+-56+ and CD3+-CD19+.
  • Group F of men showed higher levels of occupational stress and both STAI I and II than groups E and G.
  • The scores of STAI I and II were negatively correlated with the cytotoxic activity expressed per ml of blood and/or total lymphocytes. and/or NK CD45+-CD16+-CD56+ cells.
  • [MeSH-minor] Adult. Female. Humans. Lymphocyte Subsets. Male. Middle Aged. Universities


42. Kettle R, Simmons J, Schindler F, Jones P, Dicker T, Dubois G, Giddings J, Van Heeke G, Jones CE: Regulation of neuregulin 1beta1-induced MUC5AC and MUC5B expression in human airway epithelium. Am J Respir Cell Mol Biol; 2010 Apr;42(4):472-81
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  • The mucins, MUC5AC and MUC5B, contribute to the viscoelastic properties of mucus, and are found at elevated levels in the airways of individuals with chronic respiratory diseases.
  • The T helper type 2 cell cytokine, IL-13, is known to regulate MUC5AC expression in goblet cells of the airways, although much less is known about the regulation of MUC5B expression.
  • NRG1beta1-induced expression of MU5AC and MUC5B was shown to involve v-erb-b2 erythroblastic leukemia viral oncogene homolog (ErbB) and ErbB3 receptors, but not ErbB4 receptors.
  • [MeSH-major] Gene Expression Regulation. Goblet Cells / metabolism. Mucin 5AC / biosynthesis. Mucin-5B / biosynthesis. Neuregulin-1 / metabolism
  • [MeSH-minor] Animals. Cell Line. Cells, Cultured. Chronic Disease. Humans. Interleukin-13 / metabolism. Mice. Mitogen-Activated Protein Kinase 3 / metabolism. Phosphorylation / drug effects. Protein Kinase Inhibitors / pharmacology. Receptor, Epidermal Growth Factor / metabolism. Receptor, ErbB-2 / metabolism. Receptor, ErbB-3 / metabolism. Receptor, ErbB-4. Respiration Disorders / metabolism. Th2 Cells / metabolism. p38 Mitogen-Activated Protein Kinases / metabolism

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  • (PMID = 19556605.001).
  • [ISSN] 1535-4989
  • [Journal-full-title] American journal of respiratory cell and molecular biology
  • [ISO-abbreviation] Am. J. Respir. Cell Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interleukin-13; 0 / MUC5AC protein, human; 0 / MUC5B protein, human; 0 / Mucin 5AC; 0 / Mucin-5B; 0 / NRG1 protein, human; 0 / Neuregulin-1; 0 / Protein Kinase Inhibitors; EC 2.7.10.1 / ERBB2 protein, human; EC 2.7.10.1 / ERBB4 protein, human; EC 2.7.10.1 / Erbb4 protein, mouse; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2; EC 2.7.10.1 / Receptor, ErbB-3; EC 2.7.10.1 / Receptor, ErbB-4; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases
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43. Turner SJ, Zhuang S, Zhang T, Boss GR, Pilz RB: Effects of lovastatin on Rho isoform expression, activity, and association with guanine nucleotide dissociation inhibitors. Biochem Pharmacol; 2008 Jan 15;75(2):405-13
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  • 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (EC1.1.1.88) inhibitors (statins) reduce cholesterol synthesis and prevent cardiovascular disease; they can also inhibit prenylation of Ras and Rho proteins, and have anti-neoplastic effects.
  • We found that the HMG-CoA reductase inhibitor lovastatin markedly induced the expression of RhoA, B, and C in human erythroleukemia (HEL) cells.

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  • (PMID = 17920041.001).
  • [ISSN] 0006-2952
  • [Journal-full-title] Biochemical pharmacology
  • [ISO-abbreviation] Biochem. Pharmacol.
  • [Language] ENG
  • [Grant] United States / NIAMS NIH HHS / AR / R01 AR051300-07; United States / NIAMS NIH HHS / AR / AR051300-07; United States / NIAMS NIH HHS / AR / AR051300-09; United States / NIAMS NIH HHS / AR / R01-AR051300; United States / NIAMS NIH HHS / AR / AR051300-08; United States / NHLBI NIH HHS / HL / 5T32-HL07261; United States / NIAMS NIH HHS / AR / R01 AR051300-09; United States / NHLBI NIH HHS / HL / T32 HL007261; United States / NIAMS NIH HHS / AR / R01 AR051300; United States / NIAMS NIH HHS / AR / R01 AR051300-08
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / ARHGDIA protein, human; 0 / Guanine Nucleotide Dissociation Inhibitors; 0 / Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0 / RHOC protein, human; 0 / rho Guanine Nucleotide Dissociation Inhibitor alpha; 0 / rho-Specific Guanine Nucleotide Dissociation Inhibitors; 124671-05-2 / RHOA protein, human; 86-01-1 / Guanosine Triphosphate; 9LHU78OQFD / Lovastatin; EC 3.6.5.2 / rho GTP-Binding Proteins; EC 3.6.5.2 / rhoA GTP-Binding Protein; EC 3.6.5.2 / rhoB GTP-Binding Protein
  • [Other-IDs] NLM/ NIHMS37750; NLM/ PMC2228324
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44. Einarsdóttir K, Rosenberg LU, Humphreys K, Bonnard C, Palmgren J, Li Y, Li Y, Chia KS, Liu ET, Hall P, Liu J, Wedrén S: Comprehensive analysis of the ATM, CHEK2 and ERBB2 genes in relation to breast tumour characteristics and survival: a population-based case-control and follow-up study. Breast Cancer Res; 2006;8(6):R67
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  • [Title] Comprehensive analysis of the ATM, CHEK2 and ERBB2 genes in relation to breast tumour characteristics and survival: a population-based case-control and follow-up study.
  • BACKGROUND: Mutations in the ataxia-telangiectasia mutated (ATM) and checkpoint kinase 2 (CHEK2) genes and amplification of the v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2) gene have been suggested to have an important role in breast cancer aetiology.
  • However, whether common variation in these genes has a role in the development of breast cancer or breast cancer survival in humans is still not clear.
  • METHODS: We performed a comprehensive haplotype analysis of the ATM, CHEK2 and ERBB2 genes in a Swedish population-based study, which included 1,579 breast cancer cases and 1,516 controls.
  • We selected seven haplotype-tagging SNPs (tagSNPs) in the ATM gene, six tagSNPs in the CHEK2 gene and seven tagSNPs in the ERBB2 gene that predicted both haplotypic and single locus variations in the respective genes with R2 values > or = 0.8.
  • RESULTS: We found no association between any genetic variation in the ATM, CHEK2 or ERBB2 genes and breast cancer survival or the risk of developing tumours with certain characteristics.
  • CONCLUSION: Our results indicate that common variants in the ATM, CHEK2 or ERBB2 genes are not involved in modifying breast cancer survival or the risk of tumour-characteristic-defined breast cancer.

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  • (PMID = 17132159.001).
  • [ISSN] 1465-542X
  • [Journal-full-title] Breast cancer research : BCR
  • [ISO-abbreviation] Breast Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA104021; United States / NCI NIH HHS / CA / R01 CA 104021
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / DNA-Binding Proteins; 0 / Tumor Suppressor Proteins; EC 2.7.1.11 / Checkpoint Kinase 2; EC 2.7.11.1 / ATM protein, human; EC 2.7.11.1 / Ataxia Telangiectasia Mutated Proteins; EC 2.7.11.1 / CHEK2 protein, human; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
  • [Other-IDs] NLM/ PMC1797028
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45. Langebrake C, Creutzig U, Reinhardt D: Immunophenotype of Down syndrome acute myeloid leukemia and transient myeloproliferative disease differs significantly from other diseases with morphologically identical or similar blasts. Klin Padiatr; 2005 May-Jun;217(3):126-34
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  • [Title] Immunophenotype of Down syndrome acute myeloid leukemia and transient myeloproliferative disease differs significantly from other diseases with morphologically identical or similar blasts.
  • BACKGROUND AND OBJECTIVES: Children with Down Syndrome (DS) have a 20-40 fold increased risk of developing acute myeloid leukemia (AML), mainly of the megakaryoblastic subtype (AMKL).
  • Approximately 10 % of newborns with DS show transient myeloproliferative disease (TMD) which normally resolves spontaneously.
  • The blast cells of both entities show megakaryoblastic/erythroblastic features (M7/M6) and cannot be distinguished by morphological characteristics.
  • Non-DS children with morphologically related diseases, i. e. myelodysplastic syndrome (MDS), juvenile myelomonocytic leukemia (JMML), or AML-M6 and AML-M7, did not show this expression profile.
  • The higher amount of CD34 co-expression in TMD may be interpreted to indicate that TMD is a slightly more immature disease than DS-AMKL.
  • [MeSH-major] Down Syndrome / complications. Immunophenotyping. Leukemia, Myeloid / immunology. Myeloproliferative Disorders / immunology
  • [MeSH-minor] Acute Disease. Adolescent. Child. Child, Preschool. Data Interpretation, Statistical. Diagnosis, Differential. Flow Cytometry / methods. Humans. Infant. Infant, Newborn. Leukemia, Megakaryoblastic, Acute / diagnosis. Leukemia, Megakaryoblastic, Acute / immunology. Microscopy, Fluorescence / methods. Sensitivity and Specificity. Time Factors


46. Ratel D, Ravanat JL, Charles MP, Platet N, Breuillaud L, Lunardi J, Berger F, Wion D: Undetectable levels of N6-methyl adenine in mouse DNA: Cloning and analysis of PRED28, a gene coding for a putative mammalian DNA adenine methyltransferase. FEBS Lett; 2006 May 29;580(13):3179-84
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  • [Title] Undetectable levels of N6-methyl adenine in mouse DNA: Cloning and analysis of PRED28, a gene coding for a putative mammalian DNA adenine methyltransferase.
  • Three methylated bases, 5-methylcytosine, N4-methylcytosine and N6-methyladenine (m6A), can be found in DNA.
  • To reinvestigate the presence of m6A in mammalian DNA, we used a highly sensitive method capable of detecting one N6-methyldeoxyadenosine per million nucleosides.
  • Our results suggest that the total mouse genome contains, if any, less than 10(3) m6A.

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  • (PMID = 16684535.001).
  • [ISSN] 0014-5793
  • [Journal-full-title] FEBS letters
  • [ISO-abbreviation] FEBS Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA, Mitochondrial; 5142-22-3 / 1-methyladenine; EC 2.1.1.72 / PRED28 protein, mouse; EC 2.1.1.72 / Site-Specific DNA-Methyltransferase (Adenine-Specific); JAC85A2161 / Adenine
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47. Brimo F, Popradi G, Michel RP, Auger M: Primary effusion lymphoma involving three body cavities. Cytojournal; 2009;6:21
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  • Primary effusion lymphoma (PEL) is a human herpes virus-8 (HHV8)-associated large-cell non-Hodgkin lymphoma localized in body cavities and presenting as pleural, peritoneal, or pericardial lymphomatous effusions.
  • We describe herein a case of PEL affecting three body cavity sites in an immunocompetent patient.
  • An examination of the fluid by cytology showed large atypical lymphocytes with abundant basophilic cytoplasm, either central or eccentric nuclei having irregular outlines, and multiple prominent nucleoli.
  • A diagnosis of PEL was rendered.
  • Despite chemotherapy and valganciclovir, the disease progressed to involve the pleural and pericardial cavities and the patient died 5 months following the initial diagnosis.
  • Although PEL is a B-cell lymphoma, it is usually of null phenotype by immunohistochemistry, and can rarely aberrantly express T-cell markers, as seen in the current case.
  • The key to the diagnosis of PEL rests on identifying HHV8 in the neoplastic cells.
  • Therefore, restricting the term of PEL only to those cases that are HHV8 positive is important in order to differentiate PEL from other lymphomas that can present as serous effusions and that carry, in general, a more favorable prognosis than PEL.

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  • (PMID = 19876384.001).
  • [ISSN] 1742-6413
  • [Journal-full-title] CytoJournal
  • [ISO-abbreviation] Cytojournal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2762694
  • [Keywords] NOTNLM ; Effusion / Epstein–Barr virus / human herpes virus-8 / lymphoma
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48. Wong SS, Vargas J, Thomas A, Fastje C, McLaughlin M, Camponovo R, Lantz RC, Heys J, Witten ML: In vivo comparison of epithelial responses for S-8 versus JP-8 jet fuels below permissible exposure limit. Toxicology; 2008 Dec 5;254(1-2):106-11
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  • [Title] In vivo comparison of epithelial responses for S-8 versus JP-8 jet fuels below permissible exposure limit.
  • This study was designed to characterize and compare the pulmonary effects in distal lung from a low-level exposure to jet propellant-8 fuel (JP-8) and a new synthetic-8 fuel (S-8).
  • A pulmonary function test performed 24h after the final exposure indicated that there was a significant increase in expiratory lung resistance in the S-8 mice, whereas JP-8 mice had significant increases in both inspiratory and expiratory lung resistance compared to control values.

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  • (PMID = 18930109.001).
  • [ISSN] 0300-483X
  • [Journal-full-title] Toxicology
  • [ISO-abbreviation] Toxicology
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / ES006694-14; United States / NIEHS NIH HHS / ES / P30 ES006694; United States / NIEHS NIH HHS / ES / ES06694; United States / NIEHS NIH HHS / ES / P30 ES006694-14
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Hydrocarbons; 0 / JP8 aviation fuel; 0 / S-8 fuel
  • [Other-IDs] NLM/ NIHMS208577; NLM/ PMC2927360
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49. Pilzer D, Saar M, Koya K, Fishelson Z: Mortalin inhibitors sensitize K562 leukemia cells to complement-dependent cytotoxicity. Int J Cancer; 2010 Mar 15;126(6):1428-35
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  • [Title] Mortalin inhibitors sensitize K562 leukemia cells to complement-dependent cytotoxicity.
  • Its elevated expression has been correlated with malignant transformation and poor cancer prognosis.
  • Treatment of human erythroleukemia K562 and colorectal carcinoma HCT116 cells with MKT-077 sensitizes them to cell death mediated by MAC but not by streptolysin O.
  • [MeSH-minor] Animals. Bacterial Proteins / pharmacology. Blotting, Western. Calcimycin / pharmacology. Cell Survival / drug effects. Dose-Response Relationship, Drug. HCT116 Cells. Hemolysis / drug effects. Humans. Ionophores / pharmacology. K562 Cells. Leukemia, Erythroblastic, Acute / genetics. Leukemia, Erythroblastic, Acute / metabolism. Leukemia, Erythroblastic, Acute / pathology. Pyridines / pharmacology. Rabbits. Recombinant Proteins / metabolism. Recombinant Proteins / pharmacology. Streptolysins / pharmacology. Thiazoles / pharmacology

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  • (PMID = 19739077.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Complement C9; 0 / HSP70 Heat-Shock Proteins; 0 / Ionophores; 0 / MKT 077; 0 / Pyridines; 0 / Recombinant Proteins; 0 / Streptolysins; 0 / Thiazoles; 0 / mortalin; 0 / streptolysin O; 37H9VM9WZL / Calcimycin
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50. Rotoli BM, Closs EI, Barilli A, Visigalli R, Simon A, Habermeier A, Bianchi N, Gambari R, Gazzola GC, Bussolati O, Dall'Asta V: Arginine transport in human erythroid cells: discrimination of CAT1 and 4F2hc/y+LAT2 roles. Pflugers Arch; 2009 Oct;458(6):1163-73
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  • [Title] Arginine transport in human erythroid cells: discrimination of CAT1 and 4F2hc/y+LAT2 roles.
  • Since arginine metabolites, such as nitric oxide and polyamines, influence the expression of genes involved in erythroid differentiation, the transport of the cationic amino acid may play an important role in erythroid cells.
  • Using erythroleukemia K562 cells and normal erythroid precursors, we demonstrate here that arginine transport in human erythroid cells is due to the additive contributions of a leucine-sensitive and leucine-insensitive component.
  • Lastly, silencing of SLC7A6, the gene for y(+)LAT2, lowers arginine transport and doubles the intracellular content of the cationic amino acid in K562 cells.
  • We conclude that arginine transport in human erythroid cells is due to both system y(+) (CAT1 transporter) and system y(+)L (4F2hc/y(+)LAT2 isoform), which mainly contribute, respectively, to the influx and to the efflux of the cationic amino acid.
  • [MeSH-major] Antigens, CD98 Heavy Chain / physiology. Erythroid Precursor Cells / metabolism
  • [MeSH-minor] Adaptor Proteins, Signal Transducing / physiology. Amino Acid Transport System y+ / metabolism. Amino Acid Transport Systems, Basic / physiology. Animals. Arginine / metabolism. Cationic Amino Acid Transporter 1 / metabolism. Gene Silencing. Humans. K562 Cells. Large Neutral Amino Acid-Transporter 1 / metabolism. Oocytes / metabolism. Xenopus laevis

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  • (PMID = 19562367.001).
  • [ISSN] 1432-2013
  • [Journal-full-title] Pflugers Archiv : European journal of physiology
  • [ISO-abbreviation] Pflugers Arch.
  • [Language] eng
  • [Grant] Italy / Telethon / / GGP07257
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Amino Acid Transport System y+; 0 / Amino Acid Transport Systems, Basic; 0 / Antigens, CD98 Heavy Chain; 0 / Cationic Amino Acid Transporter 1; 0 / LAT2 protein, human; 0 / Large Neutral Amino Acid-Transporter 1; 0 / SLC3A2 protein, human; 0 / SLC7A6 protein, human; 94ZLA3W45F / Arginine
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56. Chadburn A, Hyjek EM, Tam W, Liu Y, Rengifo T, Cesarman E, Knowles DM: Immunophenotypic analysis of the Kaposi sarcoma herpesvirus (KSHV; HHV-8)-infected B cells in HIV+ multicentric Castleman disease (MCD). Histopathology; 2008 Nov;53(5):513-24
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  • [Title] Immunophenotypic analysis of the Kaposi sarcoma herpesvirus (KSHV; HHV-8)-infected B cells in HIV+ multicentric Castleman disease (MCD).
  • AIMS: Kaposi sarcoma herpesvirus (KSHV) is aetiologically related to Kaposi sarcoma, classical and extracavitary primary effusion lymphoma (PEL; EC-PEL) and multicentric Castleman disease (MCD), entities preferentially occurring in HIV-infected individuals.
  • Characterization of HIV-associated PELs/EC-PELs suggests that the KSHV-infected malignant cells originate from a pre-terminal stage of B-cell differentiation.
  • However, only limited phenotypic studies have been performed on HIV+ MCD, including for PR domain containing 1 with zinc finger domain/B lymphocyte-induced maturation protein 1 (PRDM1/BLIMP1), a key regulator of terminal B-cell differentiation.
  • METHODS AND RESULTS: Double immunohistochemistry and immunohistochemistry-in situ hybridization were used to characterize the KSHV-infected cells in MCD; the results were compared with the phenotypic profiles of 39 PELs/EC-PELs and seven PEL cell lines.
  • Whereas the immunophenotype of KSHV-infected cells in MCD and malignant KSHV+ PEL cells was similar (PAX5, Bcl-6-; PRDM1/BLIMP1, IRF4/MUM1+; Ki67+), the MCD KSHV-infected cells differed, as they expressed OCT2, cytoplasmic lambda immunoglobulin; variably expressed CD27; lacked CD138; and were Epstein-Barr virus negative.
  • CONCLUSIONS: Although both PEL and MCD originate from KSHV-infected pre-terminally differentiated B cells, these findings, with previously reported genetic studies, indicate HIV+ MCD may arise from extrafollicular B cells, whereas PELs may originate from cells that have traversed the germinal centre.
  • [MeSH-major] B-Lymphocytes / virology. Giant Lymph Node Hyperplasia / virology. HIV Infections / complications. Herpesviridae Infections / virology. Herpesvirus 8, Human. Lymphoma, Primary Effusion / virology


57. Lee TL, Shyu YC, Hsu PH, Chang CW, Wen SC, Hsiao WY, Tsai MD, Shen CK: JNK-mediated turnover and stabilization of the transcription factor p45/NF-E2 during differentiation of murine erythroleukemia cells. Proc Natl Acad Sci U S A; 2010 Jan 5;107(1):52-7
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  • [Title] JNK-mediated turnover and stabilization of the transcription factor p45/NF-E2 during differentiation of murine erythroleukemia cells.
  • We have characterized the signal transduction pathways regulating the catabolisis of p45/NF-E2, a bZIP factor activating the erythroid and megakaryocytic gene transcription.
  • Significantly, this regulatory pathway of p45/NF-E2 by P-JNK exists only in uninduced murine erythroleukemia (MEL) cells but not in differentiated MEL cells in which JNK is inactivated on DMSO induction.
  • Based on the above data and analysis of the chromatin-binding kinetics of p45/NF-E2 and the erythroid gene repressor Bach1 during the early phase of MEL differentiation, we suggest a model for the regulation of erythroid maturation.
  • In the model, the posttranslational modifications and turnover of p45/NF-E2, as mediated by P-JNK, contribute to the control of its homeostatic concentration and consequently, its regulatory functions in the progression of erythroid differentiation and erythroid gene expression.
  • [MeSH-major] Cell Differentiation / physiology. Gene Expression Regulation, Developmental. JNK Mitogen-Activated Protein Kinases / metabolism. Leukemia, Erythroblastic, Acute / metabolism. NF-E2 Transcription Factor, p45 Subunit / metabolism. Signal Transduction / physiology
  • [MeSH-minor] Animals. Basic-Leucine Zipper Transcription Factors / genetics. Basic-Leucine Zipper Transcription Factors / metabolism. Cell Line, Tumor. Fanconi Anemia Complementation Group Proteins / genetics. Fanconi Anemia Complementation Group Proteins / metabolism. Gene Expression Regulation, Leukemic. Humans. Mice. Phosphorylation. Proteasome Endopeptidase Complex / metabolism. Recombinant Fusion Proteins / genetics. Recombinant Fusion Proteins / metabolism

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  • (PMID = 19966288.001).
  • [ISSN] 1091-6490
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BACH1 protein, human; 0 / Basic-Leucine Zipper Transcription Factors; 0 / Fanconi Anemia Complementation Group Proteins; 0 / NF-E2 Transcription Factor, p45 Subunit; 0 / Recombinant Fusion Proteins; EC 2.7.11.24 / JNK Mitogen-Activated Protein Kinases; EC 3.4.25.1 / Proteasome Endopeptidase Complex
  • [Other-IDs] NLM/ PMC2806728
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58. Zuclich JA, Lund DJ, Stuck BE: Wavelength dependence of ocular damage thresholds in the near-ir to far-ir transition region: proposed revisions to MPES. Health Phys; 2007 Jan;92(1):15-23
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  • This report summarizes the results of a series of infrared (IR) laser-induced ocular damage studies conducted over the past decade.
  • The studies examined retinal, lens, and corneal effects of laser exposures in the near-IR to far-IR transition region (wavelengths from 1.3-1.4 mum with exposure durations ranging from Q-switched to continuous wave).
  • The corneal and retinal damage thresholds are tabulated for all pulsewidth regimes, and the wavelength dependence of the IR thresholds is discussed and contrasted to laser safety standard maximum permissible exposure limits.
  • The analysis suggests that the current maximum permissible exposure limits could be beneficially revised to (1) relax the IR limits over wavelength ranges where unusually high safety margins may unintentionally hinder applications of recently developed military and telecommunications laser systems;.
  • (2) replace step-function discontinuities in the IR limits by continuously varying analytical functions of wavelength and pulsewidth which more closely follow the trends of the experimental retinal (for point-source laser exposures) and corneal ED50 threshold data; and (3) result in an overall simplification of the permissible exposure limits over the wavelength range from 1.2-2.6 mum.
  • A specific proposal for amending the IR maximum permissible exposure limits over this wavelength range is presented.
  • [MeSH-major] Eye Injuries / diagnosis. Eye Injuries / etiology. Infrared Rays / adverse effects. Radiation Injuries / diagnosis. Radiation Injuries / etiology. Radiation Protection / standards. Radiometry / standards

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  • (PMID = 17164595.001).
  • [ISSN] 0017-9078
  • [Journal-full-title] Health physics
  • [ISO-abbreviation] Health Phys
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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59. Suh HC, Gooya J, Renn K, Friedman AD, Johnson PF, Keller JR: C/EBPalpha determines hematopoietic cell fate in multipotential progenitor cells by inhibiting erythroid differentiation and inducing myeloid differentiation. Blood; 2006 Jun 1;107(11):4308-16
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  • [Title] C/EBPalpha determines hematopoietic cell fate in multipotential progenitor cells by inhibiting erythroid differentiation and inducing myeloid differentiation.
  • C/EBPalpha is an essential transcription factor required for myeloid differentiation.
  • We found increased numbers of erythroid progenitors and erythroid cells in C/EBPalpha(-/-) fetal liver (FL).
  • Also, enforced expression of C/EBPalpha in hematopoietic stem cells resulted in a loss of erythroid progenitors and an increase in myeloid cells by inhibition of erythroid development and inducing myeloid differentiation.
  • Conditional expression of C/EBPalpha in murine erythroleukemia (MEL) cells induced myeloid-specific genes, while inhibiting erythroid-specific gene expression including erythropoietin receptor (EpoR), which suggests a novel mechanism to determine hematopoietic cell fate.
  • Thus, C/EBPalpha functions in hematopoietic cell fate decisions by the dual actions of inhibiting erythroid and inducing myeloid gene expression in multipotential progenitors.

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  • (PMID = 16469877.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CO / N01-CO-12400
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CCAAT-Enhancer-Binding Protein-alpha; 0 / Receptors, Erythropoietin
  • [Other-IDs] NLM/ PMC1895788
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60. Grossmann C, Ganem D: Effects of NFkappaB activation on KSHV latency and lytic reactivation are complex and context-dependent. Virology; 2008 May 25;375(1):94-102
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  • The latent v-FLIP gene is a strong activator of NFkappaB, and in primary effusion lymphoma (PEL) cells, blockade of NFkappaB activation is associated with enhanced lytic gene expression, while overexpression of p65 impairs expression of reporter genes driven by lytic promoters.
  • In accord with earlier work, we find that inhibition of NFkappaB signaling in PEL cells is associated with enhanced lytic reactivation of KSHV.
  • Similarly, in de novo KSHV infection of primary endothelial cells, inhibition of NFkappaB signaling leads to an increase in lytic gene expression and enhanced virion production.
  • Moreover, if NFkappaB activation is always inhibitory to lytic gene expression, one might expect its activation to be suppressed during the lytic cycle.
  • Together these data indicate that (i) the relationship of NFkappaB activation to latency and lytic reactivation is not uniform, but is dependent on the cellular context; and (ii) even though NFkappaB activation is inhibitory to lytic gene expression in some contexts, such inhibition is at least partially bypassed or overridden during lytic growth.

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  • (PMID = 18321555.001).
  • [ISSN] 0042-6822
  • [Journal-full-title] Virology
  • [ISO-abbreviation] Virology
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA073506-10; United States / NCI NIH HHS / CA / R01 CA073506; United States / NCI NIH HHS / CA / R01 CA073506-10
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / NF-kappa B
  • [Other-IDs] NLM/ NIHMS51306; NLM/ PMC2822626
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61. Daesslé LW, Lugo-Ibarra KC, Tobschall HJ, Melo M, Gutiérrez-Galindo EA, García-Hernández J, Alvarez LG: Accumulation of as, pb, and cu associated with the recent sedimentary processes in the colorado delta, South of the United States-Mexico boundary. Arch Environ Contam Toxicol; 2009 May;56(4):680-92
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  • Flushing by river and tide flows appear to be responsible of a lower pollutant deposition in the CR compared to the adjacent Hardy River (HR).
  • Arsenic in the buried clay units of the HR has concentrations above the probable toxic effect level (PEL) for dwelling organisms, with maximum concentrations of 30 microg g(-1).

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  • (PMID = 18797954.001).
  • [ISSN] 1432-0703
  • [Journal-full-title] Archives of environmental contamination and toxicology
  • [ISO-abbreviation] Arch. Environ. Contam. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Arsenicals; 0 / Soil Pollutants; 0 / Water Pollutants, Chemical; 2P299V784P / Lead; 789U1901C5 / Copper
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62. Park KS, Kang SY, Lee WI: [HLA-B27 subtypes in Korean patients with ankylosing spondylitis]. Korean J Lab Med; 2008 Feb;28(1):46-52
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  • Pel-Freez SSP Unitray HLA-B*27 kit (Dynal Biotech, USA) including 16 primers was used to define HLA-B27 subtypes from B*2701 to B*2735.
  • [MeSH-major] HLA-B27 Antigen / genetics. Spondylitis, Ankylosing / diagnosis
  • [MeSH-minor] Adult. Alleles. Female. Gene Frequency. Genotype. Humans. Korea / epidemiology. Male. Polymerase Chain Reaction. Polymorphism, Genetic. Reagent Kits, Diagnostic

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  • (PMID = 18309255.001).
  • [ISSN] 1598-6535
  • [Journal-full-title] The Korean journal of laboratory medicine
  • [ISO-abbreviation] Korean J Lab Med
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / HLA-B27 Antigen; 0 / Reagent Kits, Diagnostic
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63. Watanabe Y, Fukui N, Nunokawa A, Muratake T, Kaneko N, Kitamura H, Someya T: No association between the ERBB3 gene and schizophrenia in a Japanese population. Neurosci Res; 2007 Apr;57(4):574-8
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  • [Title] No association between the ERBB3 gene and schizophrenia in a Japanese population.
  • There is cumulative evidence that neuregulin 1 (NRG1) is a susceptibility gene for schizophrenia.
  • Postmortem studies on brains from schizophrenia patients have revealed changes in the mRNA expression levels of v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (ERBB3), one of the NRG1 receptor genes.
  • To assess whether the ERBB3 gene could be implicated in vulnerability to schizophrenia, we conducted a case-control (399 patients and 438 controls) association study in Japanese subjects.
  • [MeSH-major] Genetic Predisposition to Disease. Receptor, ErbB-3 / genetics. Schizophrenia / genetics
  • [MeSH-minor] Adult. Case-Control Studies. Female. Gene Frequency. Genotype. Humans. Japan / epidemiology. Linkage Disequilibrium. Male. Middle Aged. Polymorphism, Single Nucleotide


64. Gupta P, Gurudutta GU, Verma YK, Kishore V, Gulati S, Sharma RK, Chandra R, Saluja D: PU.1: An ETS family transcription factor that regulates leukemogenesis besides normal hematopoiesis. Stem Cells Dev; 2006 Aug;15(4):609-17
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  • In erythroid progenitors, the integration of spleen focus-forming virus (SFFV) into the PU.1 locus causes its overexpression, which blocks their terminal differentiation into erythrocytes and ultimately leads to the development of erythroleukemia.
  • However, in myeloid lineages, PU.1 promotes granulocytic and monocytic differentiation, and graded reduction in its expression blocks their differentiation or maturation and thereby causes myelogenous leukemia.
  • In the following review, we have consolidated our understanding of the role of transcription factor PU.1 in the development of erythroid as well myeloid leukemia.
  • [MeSH-major] Hematopoiesis / physiology. Leukemia, Erythroblastic, Acute / metabolism. Leukemia, Myeloid, Acute / metabolism. Proto-Oncogene Proteins c-ets / metabolism
  • [MeSH-minor] Animals. Cell Differentiation. Erythroid Cells / cytology. Humans

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  • (PMID = 16978063.001).
  • [ISSN] 1547-3287
  • [Journal-full-title] Stem cells and development
  • [ISO-abbreviation] Stem Cells Dev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins c-ets
  • [Number-of-references] 44
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65. Herok R, Konopacka M, Polanska J, Swierniak A, Rogolinski J, Jaksik R, Hancock R, Rzeszowska-Wolny J: Bystander effects induced by medium from irradiated cells: similar transcriptome responses in irradiated and bystander K562 cells. Int J Radiat Oncol Biol Phys; 2010 May 1;77(1):244-52
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  • This work analyzes and compares changes in global transcript levels induced by direct irradiation and by bystander effects in K562 (human erythroleukemia) cells.
  • RESULTS: The level of the majority (72%) of transcripts changed similarly (increase, decrease, or no change) in cells grown in irradiation-conditioned medium or irradiated, whereas only 0.6% showed an opposite response.
  • Transcript level changes in bystander and irradiated cells were significantly different from those in untreated cells grown for the same amount of time and were confirmed by quantitative reverse transcriptase-polymerase chain reaction for selected genes.
  • [MeSH-major] Bystander Effect / radiation effects. Culture Media, Conditioned / pharmacology. Gene Expression Profiling / methods. K562 Cells / radiation effects. Signal Transduction / radiation effects

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  • (PMID = 20394856.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Culture Media, Conditioned
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66. Cervi D, Shaked Y, Haeri M, Usenko T, Lee CR, Haigh JJ, Nagy A, Kerbel RS, Yefenof E, Ben-David Y: Enhanced natural-killer cell and erythropoietic activities in VEGF-A-overexpressing mice delay F-MuLV-induced erythroleukemia. Blood; 2007 Mar 1;109(5):2139-46
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  • [Title] Enhanced natural-killer cell and erythropoietic activities in VEGF-A-overexpressing mice delay F-MuLV-induced erythroleukemia.
  • We have previously reported that VEGF-A, in combination with MCP-5, contributes to leukemia progression within the splenic microenvironment of mice infected with F-MuLV.
  • To study the influence of constitutively elevated VEGF-A levels on the progression of erythroleukemia, mice heterozygous for a VEGF-A "hypermorphic" allele (Vegfhi/+) were inoculated with F-MuLV.
  • Unexpectedly, a significant delay in erythroleukemia was observed in Vegfhi/+ mice when compared with wild-type controls.
  • These results suggested an altered physiologic response arising from elevated VEGF-A levels that decelerated erythroleukemic progression.
  • Furthermore, higher erythroid progenitors (ie, CD34+, CD36+, and Ter119+ cells) were evident in the bone marrow, spleen, and peripheral blood of Vegfhi/+ mice.
  • The CFU-E levels were significantly elevated in Vegfhi/+ bone marrow cultures, and this elevation was blocked by a neutralizing antibody to VEGF-A receptor (VEGFR-2).
  • Moreover, erythroleukemic mice were treated with recombinant erythropoietin and, similar to diseased Vegfhi/+ mice, showed a delay in disease progression.

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  • (PMID = 17053052.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA041233; United States / NCI NIH HHS / CA / CA-41233
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / Vascular Endothelial Growth Factor A; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2
  • [Other-IDs] NLM/ PMC1801043
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67. Das DK: Serous effusions in malignant lymphomas: a review. Diagn Cytopathol; 2006 May;34(5):335-47
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  • [Title] Serous effusions in malignant lymphomas: a review.
  • Although the frequency of pleural effusion is 20-30% in non-Hodgkin's lymphoma (NHL) and Hodgkin's disease (HD), the involvement of peritoneal and pericardial cavities is uncommon.
  • Cytologic features of specific lymphoma subtypes such as lymphoblastic lymphoma, follicular center cell lymphoma, including Burkitt-type lymphoma, marginal zone lymphoma, MALT lymphoma, and anaplastic large-cell lymphoma, etc., have been described in the literature.
  • ICC not only distinguishes lymphomas from reactive lymphocytoses and SRCTs, it significantly modifies the morphologic diagnosis to achieve a better classification of lymphomas.
  • Morphometry also distinguishes reactive lymphocytoses from malignant lymphoma with a high degree of sensitivity (>85%) and specificity (>95%).
  • Although lymphomas rarely present as serous effusions without the involvement of other thoracic and extrathoracic sites, a small group of lymphomas called primary effusion lymphomas (PEL) exhibit exclusive or dominant involvement of serous cavities, without a detectable solid tumor mass.
  • Cytomorphologically, PEL is usually a large-cell lymphoma, which appears to bridge features of large-cell immunoblastic and anaplastic large-cell lymphoma (ALCL).
  • The presence of pleural effusion at the time of presentation is not only associated with extremely poor outcome of lymphomas, it is also a predictor of disease relapse after chemotherapy and decreased survival.
  • In such situations, cytology along with ancillary studies not only gives a quick diagnosis of lymphoma, but also offers prognostically significant information such as classification of lymphomas, its grade and immunophenotype, and presence/absence of viral DNAs and tumor lysis syndrome.
  • [MeSH-major] Cytodiagnosis / methods. Lymphoma / complications. Pleural Effusion, Malignant / etiology
  • [MeSH-minor] Ascitic Fluid / pathology. Carcinoma, Small Cell / pathology. Diagnosis, Differential. Female. Hodgkin Disease / pathology. Humans. Immunophenotyping. Lymphocytosis / pathology. Male. Pericardial Effusion / etiology. Pericardial Effusion / pathology. Reed-Sternberg Cells / pathology

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  • (PMID = 16604559.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 136
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68. Vizirianakis IS, Tsiftsoglou AS: Blockade of murine erythroleukemia cell differentiation by hypomethylating agents causes accumulation of discrete small poly(A)- RNAs hybridized to 3'-end flanking sequences of beta(major) globin gene. Biochim Biophys Acta; 2005 Mar 22;1743(1-2):101-14
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  • [Title] Blockade of murine erythroleukemia cell differentiation by hypomethylating agents causes accumulation of discrete small poly(A)- RNAs hybridized to 3'-end flanking sequences of beta(major) globin gene.
  • Induction of murine erythroleukemia (MEL) cell differentiation is accompanied by transcriptional activation of globin genes and biosynthesis of hemoglobin.
  • Search within the 3'-end flanking sequences of beta(major) globin gene revealed the presence of a B1 repeat element, several ATG initiation codons, a GATA-1 consensus sequence and sequences recognized by AP-1/NF-E2 and erythroid Krüppel-like factor (EKLF) transcription factors.
  • These data taken together indicate that exposure of MEL cells to hypomethylating agents promotes accumulation of relatively small discrete RNA transcripts lacking poly(A) tail regardless of the presence or absence of inducer dimethylsulfoxide (DMSO).
  • However, the relative steady-state level of small RNAs was comparatively higher in cells co-exposed to inducer and each one of the hypomethylating agents.
  • [MeSH-major] Adenosine / analogs & derivatives. DNA Methylation. Enzyme Inhibitors / pharmacology. Globins / genetics. Leukemia, Erythroblastic, Acute / metabolism. RNA, Messenger / chemistry

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  • (PMID = 15777845.001).
  • [ISSN] 0006-3002
  • [Journal-full-title] Biochimica et biophysica acta
  • [ISO-abbreviation] Biochim. Biophys. Acta
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA Primers; 0 / DNA-Binding Proteins; 0 / Enzyme Inhibitors; 0 / Kruppel-Like Transcription Factors; 0 / RNA, Messenger; 0 / Repressor Proteins; 0 / Transcription Factor AP-1; 0 / Transcription Factors; 0TQU7668EI / Cycloleucine; 102052-95-9 / 3-deazaneplanocin; 24937-83-5 / Poly A; 63231-63-0 / RNA; 72877-50-0 / neplanocin A; 9004-22-2 / Globins; 9007-49-2 / DNA; K72T3FS567 / Adenosine; YOW8V9698H / Dimethyl Sulfoxide
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69. Srinivas U, Kumar R, Pati H, Saxena R, Tyagi S: Sub classification and clinico-hematological correlation of 40 cases of acute erythroleukemia - can proerythroblast/myeloblast and proerythroblast/total erythroid cell ratios help subclassify? Hematology; 2007 Oct;12(5):381-5
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  • [Title] Sub classification and clinico-hematological correlation of 40 cases of acute erythroleukemia - can proerythroblast/myeloblast and proerythroblast/total erythroid cell ratios help subclassify?
  • The clinico-hematological profile of 40 cases of acute erythroleukemia (AEL) was evaluated.
  • These were subclassified into three types, namely AML M6a, M6b and M6c based on the myeloblast and proerythroblast percentages.
  • As AEL is biologically an "erythroid predominant" disease, two ratios (PE/MB, PE/TEC) with proerythroblasts as numerator have been formulated.
  • An attempt has been made to assess the difference in these ratios in subclassified AEL.
  • There were 29 M6a, 2M6b,and 9 M6 c patients, which were subclassified using the criteria proposed by Mazzella et al.
  • The incidence of AEL in our study was 3.7%, predominantly affecting males with a predilection to younger age in contrast to Western studies.
  • Both PE/MB and PE/TEC ratios were higher in M6b and M6c in comparison to M6a.
  • The subclassification of AEL becomes essential especially in the era of lineage-targeted therapies, which can lead to the development and use of erythroid specific treatments in the near future.
  • [MeSH-major] Leukemia, Erythroblastic, Acute / classification
  • [MeSH-minor] Adult. Age Factors. Aged. Cell Count. Erythroblasts. Erythroid Cells. Female. Granulocyte Precursor Cells. Humans. Incidence. Male. Middle Aged. Sex Factors

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  • (PMID = 17852448.001).
  • [ISSN] 1607-8454
  • [Journal-full-title] Hematology (Amsterdam, Netherlands)
  • [ISO-abbreviation] Hematology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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70. Coupland SE, Charlotte F, Mansour G, Maloum K, Hummel M, Stein H: HHV-8-associated T-cell lymphoma in a lymph node with concurrent peritoneal effusion in an HIV-positive man. Am J Surg Pathol; 2005 May;29(5):647-52
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  • [Title] HHV-8-associated T-cell lymphoma in a lymph node with concurrent peritoneal effusion in an HIV-positive man.
  • Primary effusion lymphoma (PEL) is an uncommon large cell lymphoma, usually seen in human immunodeficiency virus (HIV)-infected patients.
  • PEL is characterized by various clinical, histomorphologic, and immunophenotypical features, and is associated with the human herpes virus 8 (HHV-8).
  • PEL may present as either a body cavity-based lymphomatous effusion or a solid tumor mass.
  • Most so-called "solid PEL" usually have an extranodal location; exceptionally rarely, they occur in lymph nodes.
  • The majority of PEL consist of malignant cells of B-cell genotype; seldom they are of T-cell origin.
  • We report a rare case of HHV-8-associated "solid PEL" of T-cell type in a 41-year-old HIV-seropositive man with a concomitant peritoneal effusion.
  • The T-cell lymphoma was diagnosed on the basis of morphologic, immunophenotypic, and molecular findings of a lymph node biopsy.
  • The tumor cells strongly expressed CD45R0, CD7, CD43, MUM1/IRF4, CD30, HHV-8, and EBER, and demonstrated a clonal rearrangement of T-cell receptor-gamma chain gene.
  • The following case provides another example of a lymph node-based "solid" PEL, demonstrating the variety within the spectrum of HHV-8-associated lymphoma.
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Clone Cells. Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor. Humans. Male

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  • (PMID = 15832089.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Clinical Conference; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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71. Yamaguchi T, Koga T, Katsuki S: Water proton spin-lattice relaxation time during the apoptotic process in ultraviolet-irradiated murine erythroleukemia cells. J Physiol Sci; 2009 Mar;59(2):131-6
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  • [Title] Water proton spin-lattice relaxation time during the apoptotic process in ultraviolet-irradiated murine erythroleukemia cells.
  • Thus, we examined the (1)H spin-lattice relaxation time (T1) of intracellular water during apoptosis in murine erythroleukemia (MEL) cells.
  • [MeSH-major] Apoptosis / radiation effects. Leukemia, Erythroblastic, Acute / pathology. Leukemia, Erythroblastic, Acute / radiotherapy. Osmosis / radiation effects. Protons. Water
  • [MeSH-minor] Animals. Caspases / metabolism. Cell Line, Tumor. Cell Membrane / radiation effects. Cell Membrane / ultrastructure. Cell Size / radiation effects. DNA Fragmentation / radiation effects. Disease Models, Animal. Mice. Ultraviolet Rays

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  • (PMID = 19340553.001).
  • [ISSN] 1880-6562
  • [Journal-full-title] The journal of physiological sciences : JPS
  • [ISO-abbreviation] J Physiol Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Protons; 059QF0KO0R / Water; EC 3.4.22.- / Caspases
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72. Dombrowski F, Klotz L, Bannasch P, Evert M: Renal carcinogenesis in models of diabetes in rats: metabolic changes are closely related to neoplastic development. Diabetologia; 2007 Dec;50(12):2580-90
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  • METHODS: Rats (n = 850), which were either spontaneously diabetic, streptozotocin-diabetic or normoglycaemic, were examined with special reference to Armanni-Ebstein lesions (AEL).
  • RESULTS: Irrespective of the cause of diabetes, diabetic but not normoglycaemic rats developed typical glycogenotic clear-cell AEL.
  • AEL showed strong proliferative activity, which was nearly completely inhibited by EGF receptor blockade (Gefitinib treatment).
  • Many findings suggested a stepwise development of RCCs from AEL.
  • In contrast to the proximal tubules, the distal tubular system, including glycogenotic AEL, had the same levels of enzyme activities as RCC (e.g. high glycogen phosphorylase and synthase activity, lack of glucose 6-phosphatase activity) and the same expression patterns of cytokeratin 7 and several growth factors, along with their receptors and signal transduction proteins (TGF-alpha, EGF receptor, IGF-I, IGF-I receptor, IGF-II receptor, insulin receptor substrate 1, v-raf-1 murine leukemia viral oncogene homologue 1 and mitogen activated protein kinase kinase 1).
  • In addition, direct morphological transitions between distal tubules, AEL and RCCs were frequently observed.
  • All these findings indicate a common origin and a precursor-product relationship of AEL and RCCs.
  • [MeSH-minor] Animals. Cell Proliferation. Disease Models, Animal. Disease Progression. Intercellular Signaling Peptides and Proteins / metabolism. Keratin-7 / metabolism. Kidney / pathology. Male. Precancerous Conditions / enzymology. Precancerous Conditions / metabolism. Precancerous Conditions / pathology. Rats. Rats, Inbred Lew. Rats, Sprague-Dawley. Signal Transduction. Streptozocin. Time Factors

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  • (PMID = 17952403.001).
  • [ISSN] 0012-186X
  • [Journal-full-title] Diabetologia
  • [ISO-abbreviation] Diabetologia
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Intercellular Signaling Peptides and Proteins; 0 / Keratin-7; 5W494URQ81 / Streptozocin
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73. Pech D, Vidal-Martínez VM, Aguirre-Macedo ML, Gold-Bouchot G, Herrera-Silveira J, Zapata-Pérez O, Marcogliese DJ: The checkered puffer (Spheroides testudineus) and its helminths as bioindicators of chemical pollution in Yucatan coastal lagoons. Sci Total Environ; 2009 Mar 15;407(7):2315-24
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  • Results from sediment analyses demonstrated the presence of hydrocarbons, organochlorine pesticides and polychlorinated biphenyls at varying concentrations, some of which exceeded the Probability Effect Level (PEL).

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  • (PMID = 19135703.001).
  • [ISSN] 0048-9697
  • [Journal-full-title] The Science of the total environment
  • [ISO-abbreviation] Sci. Total Environ.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Water Pollutants, Chemical; 059QF0KO0R / Water
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74. Patel BB, Gupta D, Elliott AA, Sengupta V, Yu Y, Majumdar AP: Curcumin targets FOLFOX-surviving colon cancer cells via inhibition of EGFRs and IGF-1R. Anticancer Res; 2010 Feb;30(2):319-25
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  • Forty-eight-hour treatment of colon cancer HCT-116 and HT-29 cells with FOLFOX resulted in 60-70% survival, accompanied by a marked activation of insulin like growth factor-1 receptor (IGF-1R) and minor to moderate increase in epidermal growth factor receptor (EGFR), v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 (HER-2) as well as v-akt murine thymoma viral oncogene homolog 1 (AKT), cyclooxygenase-2 (COX-2) and cyclin-D1.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / pharmacology. Colonic Neoplasms / drug therapy. Receptor, Epidermal Growth Factor / metabolism. Receptor, IGF Type 1 / metabolism

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  • (PMID = 20332435.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Grant] United States / NIA NIH HHS / AG / R01 AG014343; United States / NIA NIH HHS / AG / R01 AG014343
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 0 / RNA, Small Interfering; 04ZR38536J / oxaliplatin; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, IGF Type 1; IT942ZTH98 / Curcumin; U3P01618RT / Fluorouracil
  • [Other-IDs] NLM/ NIHMS521056; NLM/ PMC3836443
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75. Schnekenburger M, Morceau F, Henry E, Blasius R, Dicato M, Trentesaux C, Diederich M: Transcriptional and post-transcriptional regulation of glutathione S-transferase P1 expression during butyric acid-induced differentiation of K562 cells. Leuk Res; 2006 May;30(5):561-8
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  • Over-expression of glutathione S-transferase P1 is related to chemotherapeutic drug resistance as well as to differentiation of human erythroleukemia cells.
  • In opposition to previously described differentiating inducers which enhance the GST-resistance phenotype, time- and concentration-dependent activation of both erythroid and megakaryocytic differentiation pathways by butyric acid progressively diminished GSTP1 mRNA expression.
  • [MeSH-major] Butyric Acid / pharmacology. Gene Expression Regulation, Enzymologic / drug effects. Glutathione S-Transferase pi / genetics. Transcription, Genetic

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  • (PMID = 16213016.001).
  • [ISSN] 0145-2126
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Messenger; 107-92-6 / Butyric Acid; EC 2.5.1.18 / GSTP1 protein, human; EC 2.5.1.18 / Glutathione S-Transferase pi
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76. Mitra AK, Krishna M: Radiation-induced bystander effect: activation of signaling molecules in K562 erythroleukemia cells. J Cell Biochem; 2007 Mar 1;100(4):991-7
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  • [Title] Radiation-induced bystander effect: activation of signaling molecules in K562 erythroleukemia cells.
  • Gap junction independent signaling mechanism was investigated using K562 human erythroleukemia cells.
  • [MeSH-minor] Collagen Type XI / metabolism. Cyclin-Dependent Kinase Inhibitor p21 / metabolism. Electrophoresis, Polyacrylamide Gel. Humans. K562 Cells. Leukemia, Erythroblastic, Acute / metabolism. Leukemia, Erythroblastic, Acute / pathology. Leukemia, Erythroblastic, Acute / physiopathology. NF-kappa B / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism. Signal Transduction / radiation effects

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  • (PMID = 17063479.001).
  • [ISSN] 0730-2312
  • [Journal-full-title] Journal of cellular biochemistry
  • [ISO-abbreviation] J. Cell. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / COL11A2 protein, human; 0 / Collagen Type XI; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / NF-kappa B; 0 / Proto-Oncogene Proteins c-bcl-2
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77. Landon P, Breysse P, Chen Y: Noise exposures of rail workers at a North American chemical facility. Am J Ind Med; 2005 Apr;47(4):364-9
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  • Peak and maximum sound levels were also recorded during each sampling period.
  • RESULTS: Full-shift noise exposures were all below the Occupational Safety and Health Administration's (OSHA) permissible exposure limit (PEL) and action level for a 12-hr workday.
  • Peak impact sound levels exceeded 140 dB in 17 of 18 samples (94%) with a mean peak sound level of 143.9 dB.
  • Maximum continuous sound levels were greater than 115 dBA in 4 of 18 samples (22%) with a mean maximum sound level of 113.1 dBA.
  • The source of peak impact sound levels was a daily exposure to a concussion caused by a sudden break in a freight airline.
  • Peak impact and maximum continuous sound levels can be attenuated through the use of hearing protection or by increasing distances from railroad noise sources.
  • [MeSH-major] Chemical Industry. Noise, Occupational. Occupational Exposure / analysis. Railroads

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  • [Copyright] Copyright (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15776466.001).
  • [ISSN] 0271-3586
  • [Journal-full-title] American journal of industrial medicine
  • [ISO-abbreviation] Am. J. Ind. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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78. Hussain AR, Al-Jomah NA, Siraj AK, Manogaran P, Al-Hussein K, Abubaker J, Platanias LC, Al-Kuraya KS, Uddin S: Sanguinarine-dependent induction of apoptosis in primary effusion lymphoma cells. Cancer Res; 2007 Apr 15;67(8):3888-97
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  • Primary effusion lymphoma (PEL) is an incurable, aggressive B-cell malignancy that develops rapid resistance to conventional chemotherapy.
  • In efforts to identify novel approaches to block proliferation of PEL cells, we found that sanguinarine, a natural compound isolated from the root plant Sanguinaria canadendid, inhibits cell proliferation and induces apoptosis in a dose-dependent manner in several PEL cell lines.
  • Our data show that sanguinarine treatment of PEL cells results in up-regulation of death receptor 5 (DR5) expression via generation of reactive oxygen species (ROS) and causes activation of caspase-8 and truncation of Bid (tBid).
  • In addition, we show that pretreatment of PEL cells with carbobenzoxy-Val-Ala-Asp-fluoromethylketone, a universal inhibitor of caspases, abrogates caspase and PARP activation and prevents cell death induced by sanguinarine.
  • Moreover, treatment of PEL cells with sanguinarine down-regulates expression of inhibitor of apoptosis proteins (IAP).
  • Taken together, our findings suggest that sanguinarine is a potent inducer of apoptosis of PEL cells via up-regulation of DR5 and raise the possibility that this agent may be of value in the development of novel therapeutic approaches for the treatment of PEL.
  • [MeSH-minor] BH3 Interacting Domain Death Agonist Protein / metabolism. Caspases / metabolism. Cell Growth Processes / drug effects. Cell Line, Tumor. Collagen Type XI / metabolism. Cytochromes c / metabolism. Dose-Response Relationship, Drug. Enzyme Activation / drug effects. Exudates and Transudates / cytology. Humans. Isoenzymes / metabolism. Membrane Potential, Mitochondrial / drug effects. Mitochondria / drug effects. Mitochondria / metabolism. Mitochondria / physiology. Molecular Conformation. Reactive Oxygen Species / metabolism. Receptors, TNF-Related Apoptosis-Inducing Ligand / biosynthesis. Receptors, TNF-Related Apoptosis-Inducing Ligand / genetics. Signal Transduction / drug effects. Up-Regulation / drug effects. bcl-2-Associated X Protein / metabolism

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  • (PMID = 17440103.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Alkaloids; 0 / BAX protein, human; 0 / BH3 Interacting Domain Death Agonist Protein; 0 / BID protein, human; 0 / Benzophenanthridines; 0 / COL11A2 protein, human; 0 / Collagen Type XI; 0 / Isoenzymes; 0 / Isoquinolines; 0 / Reactive Oxygen Species; 0 / Receptors, TNF-Related Apoptosis-Inducing Ligand; 0 / bcl-2-Associated X Protein; 9007-43-6 / Cytochromes c; AV9VK043SS / sanguinarine; EC 3.4.22.- / Caspases
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79. Kwok KW, Bjorgesaeter A, Leung KM, Lui GC, Gray JS, Shin PK, Lam PK: Deriving site-specific sediment quality guidelines for Hong Kong marine environments using field-based species sensitivity distributions. Environ Toxicol Chem; 2008 Jan;27(1):226-34
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  • As the construction of f-SSDs requires the use of a collection of responses from individual species to a chemical gradient in sediment, data screening criteria on the minimum abundance of the species were evaluated and optimized to ensure sufficient statistical power for estimating these responses.
  • The community-adjusted hazardous concentrations of 5% and 10% of the f-SSDs were adopted to represent the threshold effects level (TEL) and predicted effects level (PEL), respectively.

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  • (PMID = 18092863.001).
  • [ISSN] 0730-7268
  • [Journal-full-title] Environmental toxicology and chemistry
  • [ISO-abbreviation] Environ. Toxicol. Chem.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Environmental Pollutants; 0 / Metals, Heavy; 0 / Polycyclic Hydrocarbons, Aromatic; DFC2HB4I0K / Polychlorinated Biphenyls
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80. Cozma D, Thomas-Tikhonenko A: Kit-activating mutations in AML: lessons from PU.1-induced murine erythroleukemia. Cancer Biol Ther; 2006 Jun;5(6):579-81
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  • [Title] Kit-activating mutations in AML: lessons from PU.1-induced murine erythroleukemia.
  • Gain-of-function mutations in c-Kit have been described in a number of human cancers, including testicular germinomas, acute myeloid leukemia and gastrointestinal stromal tumors.
  • Without Kit mutations, these mice suffer from a benign disease whose hallmark is erythropoietin-dependent expansion of undifferentiated red blood cell precursors.
  • Gleevac), the authors demonstrate that Kit mutations are important for the autonomous expansion of malignant cells via the MEK/Erk1/2 and PI3K/Akt pathways.
  • These findings validate the notion that one differentiation-blocking (e.g., PU.1 activation) and one proliferative (e.g., c-Kit mutations) event are required for the development of frank leukemia.
  • [MeSH-major] Leukemia, Erythroblastic, Acute / genetics. Leukemia, Myeloid, Acute / genetics. Mutation. Proto-Oncogene Proteins / genetics. Proto-Oncogene Proteins c-kit / genetics. Trans-Activators / genetics


81. Yiakoumis X, Pangalis GA, Kyrtsonis MC, Vassilakopoulos TP, Kontopidou FN, Kalpadakis C, Korkolopoulou P, Levidou G, Androulaki A, Siakantaris MP, Sachanas S, Andreopoulos A: Primary effusion lymphoma in two HIV-negative patients successfully treated with pleurodesis as first-line therapy. Anticancer Res; 2010 Jan;30(1):271-6
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  • Primary effusion lymphoma (PEL) is a rare non-Hodgkin's lymphoma (NHL) mostly occurring in HIV-positive patients.
  • We report two HIV-negative, HHV8-positive patients with PEL of the pleural cavity who achieved a durable remission after pleurodesis with bleomycin and no systemic therapy.
  • We also perform a review of the relevant literature regarding the clinical data, treatment, and survival of PEL in HIV-negative patients.

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  • (PMID = 20150647.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 11056-06-7 / Bleomycin
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82. Hasegawa H, Chatterjee A, Cui Y, Chatterjee AK: Elevated temperature enhances virulence of Erwinia carotovora subsp. carotovora strain EC153 to plants and stimulates production of the quorum sensing signal, N-acyl homoserine lactone, and extracellular proteins. Appl Environ Microbiol; 2005 Aug;71(8):4655-63
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  • Erwinia carotovora subsp. atroseptica, E. carotovora subsp. betavasculorum, and E. carotovora subsp. carotovora produce high levels of extracellular enzymes, such as pectate lyase (Pel), polygalacturonase (Peh), cellulase (Cel), and protease (Prt), and the quorum-sensing signal N-acyl-homoserine lactone (AHL) at 28 degrees C.
  • At elevated temperatures these bacteria produce high levels of RsmA, an RNA binding protein that promotes RNA decay. E. carotovora subsp. carotovora strain EC153 is an exception in that it produces higher levels of Pel, Peh, Cel, and Prt at 34.5 degrees C than at 28 degrees C.
  • EC153 also causes extensive maceration of celery petioles and Chinese cabbage leaves at 34.5 degrees C, which correlates with a higher growth rate and higher levels of rRNA and AHL.
  • The lack of pectinase production by E. carotovora subsp. carotovora strain Ecc71 at 34.5 degrees C limits the growth of this organism in plant tissues and consequently impairs its ability to cause tissue maceration.
  • Comparative studies with ahlI (the gene encoding a putative AHL synthase), pel-1, and peh-1 transcripts documented that at 34.5 degrees C the RNAs are more stable in EC153 than in Ecc71.
  • Our data reveal that overall metabolic activity, AHL levels, and mRNA stability are responsible for the higher levels of extracellular protein production and the enhanced virulence of EC153 at 34.5 degrees C compared to 28 degrees C.
  • [MeSH-major] 4-Butyrolactone / analogs & derivatives. Gene Expression Regulation, Bacterial. Pectobacterium carotovorum / enzymology. Pectobacterium carotovorum / pathogenicity. Temperature

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  • (PMID = 16085860.001).
  • [ISSN] 0099-2240
  • [Journal-full-title] Applied and environmental microbiology
  • [ISO-abbreviation] Appl. Environ. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / RNA-Binding Proteins; 0 / Repressor Proteins; 0 / RsmA protein, Erwinia carotovora; 1192-20-7 / homoserine lactone; OL659KIY4X / 4-Butyrolactone
  • [Other-IDs] NLM/ PMC1183306
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83. Katzmann JA, Kyle RA, Benson J, Larson DR, Snyder MR, Lust JA, Rajkumar SV, Dispenzieri A: Screening panels for detection of monoclonal gammopathies. Clin Chem; 2009 Aug;55(8):1517-22
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  • BACKGROUND: The repertoire of serologic tests for identifying a monoclonal gammopathy includes serum and urine protein electrophoresis (PEL), serum and urine immunofixation electrophoresis (IFE), and quantitative serum free light chain (FLC).
  • METHODS: Patients with a PCPD and all 5 assays performed within 30 days of diagnosis were included (n = 1877).
  • The diagnoses were multiple myeloma (MM) (n = 467), smoldering multiple myeloma (SMM) (n = 191), monoclonal gammopathy of undetermined significance (MGUS) (n = 524), plasmacytoma (n = 29), extramedullary plasmacytoma (n = 10), Waldenström macroglobulinemia (WM) (n = 26), primary amyloidosis (AL) (n = 581), light chain deposition disease (LCDD) (n = 18), and POEMS syndrome (n = 31).
  • CONCLUSIONS: The major impact of using a simplified screening panel of serum PEL plus FLC rather than PEL, IFE, and FLC is an 8% reduction in sensitivity for MGUS, 23% for POEMS (7 patients), 4% for plasmacytoma (1 patient), 1% for AL, and 0.5% for SMM.

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  • (PMID = 19520758.001).
  • [ISSN] 1530-8561
  • [Journal-full-title] Clinical chemistry
  • [ISO-abbreviation] Clin. Chem.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P01 CA062242; United States / NCI NIH HHS / CA / R01 CA107476; United States / NCI NIH HHS / CA / CA 107476; United States / NCI NIH HHS / CA / CA 62242
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Blood Proteins; 0 / Immunoglobulin Light Chains
  • [Other-IDs] NLM/ NIHMS498187; NLM/ PMC3773468
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84. Mitsudomi T: Advances in target therapy for lung cancer. Jpn J Clin Oncol; 2010 Feb;40(2):101-6
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  • About half of the Japanese patients with lung cancers harbor an activating mutation of the epidermal growth factor receptor gene and they are very sensitive to epidermal growth factor receptor tyrosine kinase inhibitors.
  • Target therapies against echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase fusion protein or a mutated ERBB2 (v-ERB-B avian erythroblastic leukemia viral oncogene homologue 2) present in approximately 5% and approximately 3% of the Japanese patients with adenocarcinomas, respectively, are currently under development.
  • Through these collaborations among clinicians, basic researchers and pharmaceutical companies, it should be possible to individualize lung cancer treatment to turn this fatal disease into a chronic disorder and, eventually, to cure it.


85. Johnston EI, Beach RA, Waldrop SM, Lawson D, Cohen C: Rapid intraoperative immunohistochemical evaluation of sentinel lymph nodes for metastatic breast carcinoma. Appl Immunohistochem Mol Morphol; 2006 Mar;14(1):57-62
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  • The authors assessed the accuracy and turnaround time of a newly developed RIHC method for pancytokeratin (RIHC-CK).
  • Results were compared with previous intraoperative touch preparations, frozen sections, hematoxylin and eosin (Perm H&E), and AEl/3-immunostained permanent sections (Perm CK).

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  • (PMID = 16540732.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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86. Sipko T, Chantsoulis-Supińska M, Zmuda M, Zwoliński J: Postural balance in the early post-operative period in patients with intervertebral disk disease following surgery. Ortop Traumatol Rehabil; 2008 May-Jun;10(3):226-37
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  • [Title] Postural balance in the early post-operative period in patients with intervertebral disk disease following surgery.
  • BACKGROUND: The authors assumed that advanced lumbar disk disease contributes to disorders of body balance and asymmetry of foot pressure force on the ground.
  • A PEL 38 MEDICAPTEURS platform was used to measure foot pressure forces on the ground.
  • CONCLUSIONS: Herniated disk disease in the lumbar spine causes disturbances of body posture balance, such as transposition of pelvis to the left or right and asymmetry of foot pressure forces on the ground due to pain radiating to one of the lower limbs.

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  • (PMID = 18552760.001).
  • [ISSN] 1509-3492
  • [Journal-full-title] Ortopedia, traumatologia, rehabilitacja
  • [ISO-abbreviation] Ortop Traumatol Rehabil
  • [Language] eng; pol
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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87. Subramanian A, Hegde S, Correll PH, Paulson RF: Mutation of the Lyn tyrosine kinase delays the progression of Friend virus induced erythroleukemia without affecting susceptibility. Leuk Res; 2006 Sep;30(9):1141-9
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  • [Title] Mutation of the Lyn tyrosine kinase delays the progression of Friend virus induced erythroleukemia without affecting susceptibility.
  • During the initial phase of Friend virus (FV) induced erythroleukemia, the interaction between the viral envelope glycoprotein gp55, the Erythropoietin receptor (EpoR) and the naturally occurring truncated version of the Mst1r receptor tyrosine kinase, called Sf-Stk, drives the polyclonal expansion of infected progenitors in an erythropoietin independent manner.
  • Sf-Stk provides signals that cooperate with EpoR signals to effect expansion of erythroid progenitors.
  • The latter phase of disease is characterized by a clonal expansion of transformed leukemic cells causing an acute erythroleukemia in mice.
  • Signaling by Sf-Stk and EpoR mediated by gp55 renders erythroid progenitors Epo independent through the activation of the EpoR downstream pathways such as PI3K, MAPK and JAK/STAT.
  • However, we observe differences in the pathogenesis of Friend erythroleukemia in Lyn-/- mice.
  • Our data show that Lyn signals are not required for susceptibility to Friend erythroleukemia, but Lyn plays a role in later events, the terminal differentiation of infected cells and the expansion of transformed cells.
  • [MeSH-major] Friend murine leukemia virus. Leukemia, Erythroblastic, Acute / genetics. Leukemia, Experimental / genetics. Mutation. Retroviridae Infections / genetics. Tumor Virus Infections / genetics. src-Family Kinases / genetics
  • [MeSH-minor] Animals. Bone Marrow / enzymology. Bone Marrow / virology. Cell Differentiation / genetics. Cell Transformation, Viral / genetics. Erythroid Precursor Cells / metabolism. Erythroid Precursor Cells / virology. MAP Kinase Signaling System / genetics. Mice. Mice, Knockout. Phosphotransferases / genetics. Phosphotransferases / metabolism. Receptors, Erythropoietin / metabolism. Spleen / enzymology. Spleen / virology. Viral Envelope Proteins / metabolism

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  • (PMID = 16527351.001).
  • [ISSN] 0145-2126
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL66471; United States / NHLBI NIH HHS / HL / R01 HL066471; United States / NHLBI NIH HHS / HL / R01 HL70720
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, Erythropoietin; 0 / Viral Envelope Proteins; EC 2.7.- / Phosphotransferases; EC 2.7.10.2 / lyn protein-tyrosine kinase; EC 2.7.10.2 / src-Family Kinases
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88. Teal HE, Ni S, Xu J, Finkelstein LD, Cheng AM, Paulson RF, Feng GS, Correll PH: GRB2-mediated recruitment of GAB2, but not GAB1, to SF-STK supports the expansion of Friend virus-infected erythroid progenitor cells. Oncogene; 2006 Apr 20;25(17):2433-43
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  • [Title] GRB2-mediated recruitment of GAB2, but not GAB1, to SF-STK supports the expansion of Friend virus-infected erythroid progenitor cells.
  • Friend virus induces the development of erythroleukemia in mice through the interaction of a viral glycoprotein, gp55, with a truncated form of the Stk receptor tyrosine kinase, short form-Stk (Sf-Stk), and the EpoR.
  • Here we show that Grb2 heterozygous mice exhibit decreased susceptibility to Friend erythroleukemia and that expansion of erythroid progenitors in response to infection requires the C-terminal SH3 domain of Grb2.
  • Mice with a targeted deletion in Gab2 are less susceptible to Friend erythroleukemia and the expansion of erythroid progenitor cells in response to infection can be rescued by expression of Gab2, but not Gab1.
  • Taken together, these data indicate that a Sf-Stk/Grb2/Gab2 complex mediates the growth of primary erythroid progenitor cells in response to Friend virus.
  • [MeSH-major] Friend murine leukemia virus / pathogenicity. GRB2 Adaptor Protein / physiology. Phosphoproteins / metabolism. Receptor Protein-Tyrosine Kinases / metabolism
  • [MeSH-minor] Animals. Erythroid Precursor Cells / metabolism. Erythroid Precursor Cells / virology. Female. Immunoprecipitation. Male. Mice. Mice, Inbred BALB C. Mice, Inbred C57BL. Mice, Knockout. Signal Transduction. src Homology Domains

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  • (PMID = 16314834.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL066471; United States / NHLBI NIH HHS / HL / R01-HL66208; United States / PHS HHS / / R01-L66471
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / GRB2 Adaptor Protein; 0 / Gab1 protein, mouse; 0 / Gab2 protein, mouse; 0 / Grb2 protein, mouse; 0 / Phosphoproteins; EC 2.7.1.- / RON protein; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases
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89. Martin MJ, Rayner JC, Gagneux P, Barnwell JW, Varki A: Evolution of human-chimpanzee differences in malaria susceptibility: relationship to human genetic loss of N-glycolylneuraminic acid. Proc Natl Acad Sci U S A; 2005 Sep 6;102(36):12819-24
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  • We modified and enhanced traditional methods for measuring sialic acid (Sia)-dependent recognition of glycophorins by merozoite erythrocyte-binding proteins, eliminating interference caused by endogenous Sias on transfected cells, and by using erythroleukemia cells to allow experimental manipulation of Sia content.
  • The surprising ability of P. falciparum to cause disease in New World Aotus monkeys (geographically isolated from P. falciparum until arrival of peoples from the Old World) can be explained by parallel evolution of a human-like Sia expression pattern in these distantly related primates.

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  • (PMID = 16126901.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM032373; United States / NIGMS NIH HHS / GM / R37 GM032373; United States / NIGMS NIH HHS / GM / GM32373
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glycophorin; 0 / Neuraminic Acids; 1113-83-3 / N-glycolylneuraminic acid; EC 3.2.1.18 / Neuraminidase; GZP2782OP0 / N-Acetylneuraminic Acid
  • [Other-IDs] NLM/ PMC1200275
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90. Eilertsen GØ, Nossent JC: Erythroleukaemia complicating ANA-negative systemic lupus erythematosus. Scand J Rheumatol; 2007 Nov-Dec;36(6):478-80
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  • [Title] Erythroleukaemia complicating ANA-negative systemic lupus erythematosus.
  • [MeSH-major] Antibodies, Antinuclear / blood. Leukemia, Erythroblastic, Acute / etiology. Lupus Erythematosus, Systemic / complications

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  • (PMID = 18092272.001).
  • [ISSN] 0300-9742
  • [Journal-full-title] Scandinavian journal of rheumatology
  • [ISO-abbreviation] Scand. J. Rheumatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Antibodies, Antinuclear
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91. Constantinou C, Clemens MJ: Regulation of the phosphorylation and integrity of protein synthesis initiation factor eIF4GI and the translational repressor 4E-BP1 by p53. Oncogene; 2005 Jul 14;24(30):4839-50
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  • Activation of a temperature-sensitive form of mouse p53 in murine erythroleukaemia cells rapidly inhibits protein synthesis and causes early dephosphorylation and cleavage of protein synthesis initiation factor eIF4GI and the eIF4E-binding protein 4E-BP1.

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  • (PMID = 15897901.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / Eif4ebp1 protein, mouse; 0 / Eukaryotic Initiation Factor-4E; 0 / Eukaryotic Initiation Factor-4G; 0 / Phosphoproteins; 0 / Tumor Suppressor Protein p53; EC 2.7.- / Protein Kinases; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.1.1 / mTOR protein, mouse; EC 2.7.11.22 / CDC2 Protein Kinase; W36ZG6FT64 / Sirolimus
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92. Izdebska M, Grzanka A, Ostrowski M, Zuryń A, Grzanka D: Effect of arsenic trioxide (Trisenox) on actin organization in K-562 erythroleukemia cells. Folia Histochem Cytobiol; 2009 Jan;47(3):453-9
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  • [Title] Effect of arsenic trioxide (Trisenox) on actin organization in K-562 erythroleukemia cells.

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  • (PMID = 20164031.001).
  • [ISSN] 1897-5631
  • [Journal-full-title] Folia histochemica et cytobiologica
  • [ISO-abbreviation] Folia Histochem. Cytobiol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Actins; 0 / Arsenicals; 0 / Oxides; S7V92P67HO / arsenic trioxide
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93. Gottwein E, Cullen BR: A human herpesvirus microRNA inhibits p21 expression and attenuates p21-mediated cell cycle arrest. J Virol; 2010 May;84(10):5229-37
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  • Ectopically expressed KSHV miR-K1 specifically inhibited the expression of endogenous p21 in KSHV-negative cells and strongly attenuated the cell cycle arrest that normally occurs upon p53 activation, yet miR-K1 did not prevent the induction of other p53-responsive genes.
  • Stable knockdown of miR-K1 in latently KSHV-infected human primary effusion lymphoma (PEL) B cells revealed a derepression of p21 expression and enhanced cell cycle arrest following activation of p53.

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  • (PMID = 20219912.001).
  • [ISSN] 1098-5514
  • [Journal-full-title] Journal of virology
  • [ISO-abbreviation] J. Virol.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / R01-AI067968; United States / NIAID NIH HHS / AI / R01 AI067968; United States / NCI NIH HHS / CA / K99 CA137860-01A1; United States / NCI NIH HHS / CA / P30 CA014236; United States / NIAID NIH HHS / AI / R01 AI067968-04; United States / NCI NIH HHS / CA / K99 CA137860; United States / NCI NIH HHS / CA / K99-CA137860; United States / NIAID NIH HHS / AI / AI067968-04; United States / NCI NIH HHS / CA / P30-CA14236
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CDKN1A protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / MicroRNAs; 0 / RNA, Viral
  • [Other-IDs] NLM/ PMC2863803
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94. Ljubić N, Sucić M, Vasilj A, Lang N, Dominis M, Batinica AG, Jurković L, Siftar Z: Cytological detection of lymphoma in Douglas aspirate. Diagn Cytopathol; 2008 Oct;36(10):729-33
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  • Except in primary effusion lymphoma (PEL), serous effusions with lymphomatous cells in non-Hodgkin lymphoma (NHL) are not frequently seen as first manifestation of disease.
  • In NHL lymphoplasmacytic lymphoma (LPL) the spleen, lymph nodes, and bone marrow are frequently sites of disease and this type of NHL is usually associated with a serum paraprotein of IgM type accompanied by the clinical syndrome of Waldenström macroglobulinemia.
  • Our patient with NHL LPL type presented in this report had less frequently seen involvement of gastrointestinal tract and clinically was first manifested as effusion in Douglas space.
  • Immunocytochemical and flow cytometry analysis confirmed lymphoid cell differentiation and pathohistological diagnosis of CD20(+) LPL was set after pathohistological analysis of resected ileum.
  • [MeSH-major] Douglas' Pouch / pathology. Ileal Neoplasms / diagnosis. Ileal Neoplasms / pathology. Waldenstrom Macroglobulinemia / diagnosis. Waldenstrom Macroglobulinemia / pathology

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  • (PMID = 18773438.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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95. Yang HY, Jeong DK, Kim SH, Chung KJ, Cho EJ, Yang U, Lee SR, Lee TH: The role of peroxiredoxin III on late stage of proerythrocyte differentiation. Biochem Biophys Res Commun; 2007 Aug 10;359(4):1030-6
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  • Peroxiredoxin III (Prdx III), the mitochondrial peroxidase, was preferentially expressed in murine erythroleukemia (MEL) cells.
  • However, the mechanisms by which Prdx III regulates erythroid differentiation are unknown.
  • The intracellular ROS level of Prdx III O/E cell line was lower than D/N stable cell lines.
  • Finally, the expression level of beta-globin and GATA-1 was dramatically increased in Prdx III O/E cell line.