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1. Arumugam PI, Scholes J, Perelman N, Xia P, Yee JK, Malik P: Improved Human β-globin Expression from Self-inactivating Lentiviral Vectors Carrying the Chicken Hypersensitive Site-4 (cHS4) Insulator Element. Mol Ther; 2007 Oct;15(10):1863-1871
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  • : Effective gene therapy for β-thalassemia major (β-TM) requires consistent, high expression of human β-globin (hβ-globin) in red blood cells (RBCs).
  • Several groups have now shown that lentiviral (LV) vectors stably transmit the hβ/hγ-globin genes and large elements of the locus control region, resulting in correction of the murine thalassemia intermedia (TI) phenotype and survival of mice with the TM phenotype.
  • We observed a consistent twofold-higher hβ expression from insulated vectors in single-copy mouse erythroleukemia cell clones, an increase that resulted from reduced position effect variegation (PEV) and increased probability of expression from individual integrants.
  • These studies have important implications for vector design for clinical trials for gene therapy for hemoglobinopathies.

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  • [Copyright] Copyright © 2007 The American Society of Gene Therapy. Published by Elsevier Inc. All rights reserved.
  • (PMID = 28182916.001).
  • [ISSN] 1525-0024
  • [Journal-full-title] Molecular therapy : the journal of the American Society of Gene Therapy
  • [ISO-abbreviation] Mol. Ther.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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2. Fuchsova B, Fernández ME, Alfonso J, Frasch AC: Cysteine residues in the large extracellular loop (EC2) are essential for the function of the stress-regulated glycoprotein M6a. J Biol Chem; 2009 Nov 13;284(46):32075-88
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  • [Title] Cysteine residues in the large extracellular loop (EC2) are essential for the function of the stress-regulated glycoprotein M6a.
  • Gpm6a was identified as a stress-responsive gene in the hippocampal formation.
  • This gene is down-regulated in the hippocampus of both socially and physically stressed animals, and this effect can be reversed by antidepressant treatment.
  • Previously we showed that the stress-regulated protein M6a is a key modulator for neurite outgrowth and filopodium/spine formation.
  • In the present work, mutational analysis was used to characterize the action of M6a at the molecular level.
  • The presence of cysteines 162 and 202 is essential for the efficient cell surface expression of the M6a protein.
  • In contrast, cysteines 174 and 192, which form a disulfide bridge as shown by biochemical analysis, are not required for the efficient surface expression of M6a.
  • Their mutation to alanine does not interfere with the localization of M6a to filopodial protrusions in primary hippocampal neurons.
  • In non-permeabilized cells, these mutant proteins are not recognized by a function-blocking monoclonal antibody directed to M6a.
  • Taken together, this study demonstrates that cysteines in the EC2 domain are critical for the role of M6a in filopodium outgrowth and synaptogenesis.

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  • (PMID = 19737934.001).
  • [ISSN] 1083-351X
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gpm6a protein, rat; 0 / Membrane Glycoproteins; 0 / Nerve Tissue Proteins; K848JZ4886 / Cysteine
  • [Other-IDs] NLM/ PMC2797278
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3. Zhao J, Iida A, Ouchi Y, Satoh S, Watanabe S: M6a is expressed in the murine neural retina and regulates neurite extension. Mol Vis; 2008;14:1623-30
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  • [Title] M6a is expressed in the murine neural retina and regulates neurite extension.
  • PURPOSE: Glycoprotein m6a (M6a) is a cell-surface glycoprotein that belongs to the myelin proteolipid protein family.
  • M6a is expressed mainly in the nervous system, and its expression and function in mammalian retina have not been described.
  • Using proteomics analysis of mouse retinal membrane fractions, we identified M6a as a retinal membrane protein that is strongly expressed at embryonic stages.
  • Our aim was to reveal the function of M6a in development of mouse retina in this work.
  • METHODS: Detailed expression pattern of M6a was examined by immunostaining using frozen sections of mouse retina obtained at various developmental stages.
  • For functional analysis of M6a in mouse retinal development, we performed retorovirus-mediated overexpression of M6a in mouse retinal explant culture.
  • RESULTS: M6a transcripts were strongly expressed in embryonic retina.
  • After completion of retinal differentiation, the level of expression decreased as mouse development progressed.
  • Immunohistochemistry showed that in the immature mouse retina, M6a was strongly expressed in the axons of retinal ganglion cells.
  • After birth, M6a expression was confined to the inner plexiform layer, and finally, to the inner and outer plexiform layers of adult mouse retina.
  • M6a expression was completely paralleled by that of the synaptic marker, synaptophysin.
  • Mouse retinal progenitor cells that overexpressed M6a following retrovirus-mediated gene transfer were subjected to in vitro explant or monolayer cultures.
  • The neurite outgrowth of M6a-overexpressing retinal cells was strikingly enhanced, although M6a did not affect differentiation and proliferation.
  • CONCLUSIONS: These results suggest that M6a plays a role in retinal development by regulating neurites, and it may also function to modulate synaptic activities in the adult retina.
  • [MeSH-minor] Animals. Biomarkers / metabolism. Cell Differentiation. Cell Lineage. Cell Proliferation. Gene Expression Regulation, Developmental. Mice. Mice, Inbred ICR. Mitosis. Protein Transport. Stem Cells / cytology. Stem Cells / metabolism. Synapses / metabolism

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  • (PMID = 18776950.001).
  • [ISSN] 1090-0535
  • [Journal-full-title] Molecular vision
  • [ISO-abbreviation] Mol. Vis.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Gpm6a protein, mouse; 0 / Membrane Glycoproteins; 0 / Nerve Tissue Proteins
  • [Other-IDs] NLM/ PMC2529470
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4. van Gijn J, Gijselhart J: [Professor Pel and 'glandular fever']. Ned Tijdschr Geneeskd; 2009;153:A1215
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  • [Title] [Professor Pel and 'glandular fever'].
  • [Transliterated title] Professor Pel en 'klierkoorts'.
  • Pieter Klaesz Pel (1852-1919) was professor of internal medicine at the University of Amsterdam, for more than 35 years.
  • It is contested whether the patients in question had Hodgkin's disease.
  • [MeSH-major] Hodgkin Disease / history

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  • (PMID = 20051175.001).
  • [ISSN] 1876-8784
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Biography; English Abstract; Historical Article; Journal Article; Portraits
  • [Publication-country] Netherlands
  • [Personal-name-as-subject] Pel PK
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5. Sharma P, Dhingra KK, Roy S, Singh T: An acute myeloid leukemia M6b blast crisis with giant proerythroblasts in chronic myeloid leukemia. J Pediatr Hematol Oncol; 2009 Mar;31(3):220-1
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  • [Title] An acute myeloid leukemia M6b blast crisis with giant proerythroblasts in chronic myeloid leukemia.
  • The case of a 12 yr old female with bcr-abl positive chronic myeloid leukemia who subsequently developed a fatal AML-M6b (pure erythroleukemia) blast crisis is presented.
  • The case is unique for its rarity of occurrence and for the striking resemblance that the circulating proerythroblasts showed to the giant cells characteristically seen in Parvovirus B19-induced acute pure red cell aplasia.
  • This is, to the best of our knowledge, the first description of such cells in a blast crisis of chronic myeloid leukemia.
  • [MeSH-major] Blast Crisis / pathology. Erythroblasts / pathology. Leukemia, Erythroblastic, Acute / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 19262253.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; X6Q56QN5QC / Hydroxyurea
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6. Feng L, Musto CJ, Kemling JW, Lim SH, Suslick KS: A colorimetric sensor array for identification of toxic gases below permissible exposure limits. Chem Commun (Camb); 2010 Mar 28;46(12):2037-9
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  • [Title] A colorimetric sensor array for identification of toxic gases below permissible exposure limits.
  • A colorimetric sensor array has been developed for the rapid and sensitive detection of 20 toxic industrial chemicals (TICs) at their PELs (permissible exposure limits).

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  • (PMID = 20221484.001).
  • [ISSN] 1364-548X
  • [Journal-full-title] Chemical communications (Cambridge, England)
  • [ISO-abbreviation] Chem. Commun. (Camb.)
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / U01 ES016011; United States / NIEHS NIH HHS / ES / U01 ES016011-04; United States / NIEHS NIH HHS / ES / U01ES016011
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Gases
  • [Other-IDs] NLM/ NIHMS229286; NLM/ PMC2976522
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7. Chung IY, Choi KB, Heo YJ, Cho YH: Effect of PEL exopolysaccharide on the wspF mutant phenotypes in Pseudomonas aeruginosa PA14. J Microbiol Biotechnol; 2008 Jul;18(7):1227-34
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  • [Title] Effect of PEL exopolysaccharide on the wspF mutant phenotypes in Pseudomonas aeruginosa PA14.
  • Here, we characterized the role of cyclic diguanylate (c-di-GMP) and EPS (PEL) overproduction in the wspF mutant phenotypes of P. aeruginosa PA14 (wrinkly appearance, hyperadherence, impaired motilities, and reduced virulence in acute infections).
  • We confirmed that the elevated c-di-GMP level plays a key role in all the wspF mutant phenotypes listed above, as assessed by ectopic expression of a c-di-GMP-degrading phophodiesterase (PvrR) in the wspF mutant.
  • In contrast, PEL EPS, which is overproduced in the wspF mutant, was necessary for wrinkly appearance and hyperadherence, but not for the impaired flagellar motilities and the attenuated virulence of the wspF mutant.

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  • (PMID = 18667850.001).
  • [ISSN] 1017-7825
  • [Journal-full-title] Journal of microbiology and biotechnology
  • [ISO-abbreviation] J. Microbiol. Biotechnol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Polysaccharides, Bacterial; 61093-23-0 / bis(3',5')-cyclic diguanylic acid; EC 3.1.- / Esterases; H2D2X058MU / Cyclic GMP
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8. Liang YJ, Wu DF, Stumm R, Höllt V, Koch T: Membrane glycoprotein M6A promotes mu-opioid receptor endocytosis and facilitates receptor sorting into the recycling pathway. Cell Res; 2008 Jul;18(7):768-79
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  • [Title] Membrane glycoprotein M6A promotes mu-opioid receptor endocytosis and facilitates receptor sorting into the recycling pathway.
  • The interaction of mu-opioid receptor (MOPr) with the neuronal membrane glycoprotein M6a is known to facilitate MOPr endocytosis in human embryonic kidney 293 (HEK293) cells.
  • To further study the role of M6a in the post-endocytotic sorting of MOPr, we investigated the agonist-induced co-internalization of MOPr and M6a and protein targeting after internalization in HEK293 cells that co-expressed HA-tagged MOPr and Myc-tagged M6a.
  • We found that M6a, MOPr, and Rab 11, a marker for recycling endosomes, co-localized in endocytotic vesicles, indicating that MOPr and M6a are primarily targeted to recycling endosomes after endocytosis.
  • Furthermore, co-expression of M6a augmented the post-endocytotic sorting of delta-opioid receptors into the recycling pathway, indicating that M6a might have a more general role in opioid receptor post-endocytotic sorting.
  • The enhanced post-endocytotic sorting of MOPr into the recycling pathway was accompanied by a decrease in agonist-induced receptor down-regulation of M6a in co-expressing cells.
  • We tested the physiological relevance of these findings in primary cultures of cortical neurons and found that co-expression of M6a markedly increased the translocation of MOPrs from the plasma membrane to intracellular vesicles at steady state and significantly enhanced both constitutive and agonist-induced receptor endocytosis.
  • In conclusion, our results strongly indicate that M6a modulates MOPr endocytosis and post-endocytotic sorting and has an important role in receptor regulation.

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  • (PMID = 18574501.001).
  • [ISSN] 1748-7838
  • [Journal-full-title] Cell research
  • [ISO-abbreviation] Cell Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Membrane Glycoproteins; 0 / OPRM1 protein, human; 0 / Receptors, Opioid, mu; EC 2.1.1.- / Methyltransferases; EC 2.1.1.62 / METTL3 protein, human; EC 3.6.1.- / rab GTP-Binding Proteins; EC 3.6.1.- / rab11 protein
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9. Matsumoto T, Matsubara M, Oana K, Kasuga E, Suzuki T, Hidaka E, Shigemura T, Yamauchi K, Honda T, Ota H, Kawakami Y: First case of bacteremia due to chromosome-encoded CfxA3-beta-lactamase-producing Capnocytophaga sputigena in a pediatric patient with acute erythroblastic leukemia. Eur J Med Res; 2008 Mar 31;13(3):133-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] First case of bacteremia due to chromosome-encoded CfxA3-beta-lactamase-producing Capnocytophaga sputigena in a pediatric patient with acute erythroblastic leukemia.
  • Bacteremia due to Capnocytophaga sputigena occurred in a 4-year and 9-month-old Japanese girl patient with acute erythroblastic leukemia in Shinshu University Hospital, Japan.
  • The causative Capnocytophaga sputigena isolate was found to be a beta-lactamase-producer demonstrating to possess cfxA3 gene.
  • The gene responsible for the production of CfxA3-beta-lactamase was proved to be chromosome-encoded, by means of southern hybridization analysis.
  • [MeSH-major] Bacteremia / microbiology. Capnocytophaga / isolation & purification. Chromosomes, Bacterial. Leukemia, Erythroblastic, Acute / complications. beta-Lactamases / biosynthesis

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  • (PMID = 18499560.001).
  • [ISSN] 0949-2321
  • [Journal-full-title] European journal of medical research
  • [ISO-abbreviation] Eur. J. Med. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; EC 3.5.2.6 / beta-Lactamases
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10. Huang G, Dong R, Allen R, Davis EL, Baum TJ, Hussey RS: Developmental expression and molecular analysis of two Meloidogyne incognita pectate lyase genes. Int J Parasitol; 2005 May;35(6):685-92
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  • [Title] Developmental expression and molecular analysis of two Meloidogyne incognita pectate lyase genes.
  • Two cDNAs (designated Mi-pel-1 and Mi-pel-2) encoding pectate lyases were isolated from the root-knot nematode, Meloidogyne incognita, oesophageal gland-cell subtractive cDNA libraries, and the corresponding genomic DNAs were subsequently cloned.
  • Southern blot analyses revealed that homologues to these pectate lyase genes were broadly distributed in Meloidogyne species, and present as members of a small multigene family.
  • Mi-pel-1 and Mi-pel-2 encoded, respectively, predicted proteins of 271 and 280 amino acids, each of which was preceded by a signal peptide for secretion.
  • Interestingly, these pectate lyases showed diversity at the amino acid level, with only 31% identity and 49% similarity.
  • These pectate lyases were classified into the same family of pectate lyases with those of other phytoparasitic nematodes that contain four conserved regions characteristic of the class III pectate lyases of microbes.
  • In situ mRNA hybridisation analyses showed the transcripts of Mi-pel-1 and Mi-pel-2 accumulated exclusively within the subventral oesophageal gland cells of M. incognita.
  • These results indicated that these pectate lyases, like cellulases, could be secreted into plant tissues to facilitate the penetration and intercellular migration of M. incognita during the early stages of plant parasitism.
  • [MeSH-major] Gene Expression Regulation, Developmental / genetics. Polysaccharide-Lyases / genetics. Tylenchoidea / genetics
  • [MeSH-minor] Amino Acid Sequence. Animals. Base Sequence. Blotting, Southern / methods. Cloning, Molecular / methods. DNA, Circular / genetics. DNA, Helminth / genetics. Genes, Helminth / genetics. In Situ Hybridization / methods. Molecular Sequence Data. Phylogeny. Reverse Transcriptase Polymerase Chain Reaction / methods

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  • (PMID = 15862581.001).
  • [ISSN] 0020-7519
  • [Journal-full-title] International journal for parasitology
  • [ISO-abbreviation] Int. J. Parasitol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ AF527788/ AY327873/ AY515702/ AY515703
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Circular; 0 / DNA, Helminth; EC 4.2.2.- / Polysaccharide-Lyases; EC 4.2.2.2 / pectate lyase
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11. Cooper B, Werner HB, Flügge G: Glycoprotein M6a is present in glutamatergic axons in adult rat forebrain and cerebellum. Brain Res; 2008 Mar 4;1197:1-12
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  • [Title] Glycoprotein M6a is present in glutamatergic axons in adult rat forebrain and cerebellum.
  • Glycoprotein M6a is a neuronally expressed member of the proteolipid protein (PLP) family of tetraspans.
  • In vitro studies suggested a potential role in neurite outgrowth and spine formation and previous investigations have identified M6a as a stress-regulated gene.
  • To investigate whether the distribution of M6a correlates with neuronal structures susceptible to alterations in response to stress, we localized M6a expression in neurons of hippocampal formation, prefrontal cortex and cerebellum using in situ hybridization and confocal immunofluorescence microscopy.
  • In situ hybridization confirmed that M6a is expressed in dentate gyrus and cerebellar granule neurons and in hippocampal and cortical pyramidal neurons.
  • Confocal microscopy localized M6a immunoreactivity to distinct sites within axonal membranes, but not in dendrites or neuronal somata.
  • Moreover, M6a colocalized with synaptic markers of glutamatergic, but not GABAergic nerve terminals.
  • M6a expression in the adult brain is particularly strong in unmyelinated axonal fibers, i.e. cerebellar parallel and hippocampal mossy fibers.
  • In contrast, myelinated axons exhibit only minimal M6a immunoreactivity localized exclusively to terminal regions.
  • The present neuroanatomical data demonstrate that M6a is an axonal component of glutamatergic neurons and that it is localized to distinct sites of the axonal plasma membrane of pyramidal and granule cells.
  • [MeSH-minor] Animals. Fluorescent Antibody Technique. Gene Expression. Glutamine. In Situ Hybridization. Male. Microscopy, Confocal. RNA, Messenger / analysis. Rats. Rats, Sprague-Dawley. Vesicular Glutamate Transport Proteins / metabolism

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  • (PMID = 18241840.001).
  • [ISSN] 0006-8993
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Membrane Glycoproteins; 0 / Nerve Tissue Proteins; 0 / RNA, Messenger; 0 / Vesicular Glutamate Transport Proteins; 0RH81L854J / Glutamine
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12. Honda Y, Manabe A, Tsuchida M, Zaike Y, Masunaga A, Inoue M, Kobayashi R, Ohtsuka Y, Kikuchi A, Nakahata T, MDS Committee, the Japanese Society of Pediatric Hematology: Clinicopathological characteristics of erythroblast-rich RAEB and AML M6a in children. Int J Hematol; 2008 Dec;88(5):524-9
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  • [Title] Clinicopathological characteristics of erythroblast-rich RAEB and AML M6a in children.
  • The distinction between RAEB, RAEB-T and AML M6a is difficult when erythroblasts in the bone marrow (BM) exceed 50%.
  • We analyzed 19 children (2 RAEB, 13 RAEB-T and 4 AML M6a) enrolled in a prospective pathological central review in Japan and divided them into two groups according to the myeloblasts percentage among non-erythroid cells in BM: group A (n = 8), 5-19% myeloblasts; group B (n = 11), 20% or more myeloblasts.
  • Six with group A and seven with group B treated with AML type chemotherapy achieved complete remission.
  • Five with group A and seven with group B undergoing SCT are alive at a median of 3 years after diagnosis.
  • Erythroblast-rich RAEB and AML M6a in children have similar characteristics and may belong to a single disease entity.
  • [MeSH-major] Anemia, Refractory, with Excess of Blasts / pathology. Erythroblasts / pathology. Granulocyte Precursor Cells / pathology. Leukemia, Myeloid, Acute / pathology
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Humans. Infant. Japan. Leukocyte Count. Male. Prospective Studies. Remission Induction. Stem Cell Transplantation. Time Factors. Transplantation, Homologous

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  • (PMID = 18951200.001).
  • [ISSN] 1865-3774
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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13. Knoblauch RE, Thompson CB: Targeting tumor metabolism: biguanides as anti-neoplastic agents. J Clin Oncol; 2009 May 20;27(15_suppl):e14592
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  • : e14592 Background: During the process of malignant transformation, the tumor cell adopts a new form of metabolism, characterized by aerobic glycolysis and altered TCA cycle flux, that enable it to meet the energetic and biosynthetic demands of proliferation.
  • METHODS: We have characterized the proliferative and metabolic effects of phenformin, a member of the biguanide family of compounds used in the treatment of diabetes, on the bcr-abl expressing K562 erythroleukemia cell line, and compared the resulting phenotype to those of imatinib and rapamycin, two targeted agents used in the treatment of malignant disease.
  • Phenformin treatment eliminated the mitochondrial contribution to anabolic metabolism, through inhibition of Complex I of the Electron Transport Chain, as demonstrated by reduced oxygen consumption and intracellular ATP levels.
  • CONCLUSIONS: Our results confirm the importance of metabolism to the proliferation of malignant cells, thereby validating anabolic metabolism's potential for therapeutic intervention.

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  • (PMID = 27963742.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Speake G, Klinowska T, Hickinson M, Marshall G, Smith P, Vincent J, Anderton J, Gray N, Smith I, Ogilvie D: Characterization of AZD8931, a potent reversible small molecule inhibitor against epidermal growth factor receptor (EGFR), erythroblastic leukemia viral oncogene homolog 2 (HER2) and 3 (HER3) with a unique and balanced pharmacological profile. J Clin Oncol; 2009 May 20;27(15_suppl):11072
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  • [Title] Characterization of AZD8931, a potent reversible small molecule inhibitor against epidermal growth factor receptor (EGFR), erythroblastic leukemia viral oncogene homolog 2 (HER2) and 3 (HER3) with a unique and balanced pharmacological profile.
  • Characterization of a novel tyrosine kinase inhibitor with a potent and balanced profile against EGFR, HER2 (erbB2), and HER3 (erbB3) has been carried out.
  • These assays have provided unique insights into the pharmacology of these drugs that result from the varying levels of HER and their associated ligands.

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  • (PMID = 27963188.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Fjorback AW, Müller HK, Wiborg O: Membrane glycoprotein M6B interacts with the human serotonin transporter. J Mol Neurosci; 2009 Mar;37(3):191-200
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  • [Title] Membrane glycoprotein M6B interacts with the human serotonin transporter.
  • In the present study, using the yeast two-hybrid system, we identified the membrane glycoprotein M6B as a binding partner of SERT.
  • M6B belongs to a proteolipid protein family, which is expressed in neurons and in oligodendrocytes in the brain.
  • The co-expression of SERT with M6B results in a significant decrease in SERT-mediated serotonin uptake caused by a down-regulation of SERT surface expression.
  • Furthermore, we find, using confocal microscopy, that M6B co-localizes with SERT when transiently expressed in HEK-MSR-293 cells and when endogenously expressed in RN46A cells.
  • Taken together, our data suggest that M6B regulates the serotonin uptake by affecting cellular trafficking of the serotonin transporter.

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  • (PMID = 18581270.001).
  • [ISSN] 0895-8696
  • [Journal-full-title] Journal of molecular neuroscience : MN
  • [ISO-abbreviation] J. Mol. Neurosci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / GPM6A protein, human; 0 / GPM6B protein, human; 0 / Membrane Glycoproteins; 0 / Nerve Tissue Proteins; 0 / Serotonin Plasma Membrane Transport Proteins; 333DO1RDJY / Serotonin
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16. Richetta A, Amoruso GF, Ascoli V, Natale ME, Carboni V, Carlomagno V, Pezza M, Cimillo M, Maiani E, Mattozzi C, Calvieri S: PEL, Kaposi's sarcoma HHV8+ and idiopathic T-lymphocitopenia CD4+. Clin Ter; 2007 Mar-Apr;158(2):151-5
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  • [Title] PEL, Kaposi's sarcoma HHV8+ and idiopathic T-lymphocitopenia CD4+.
  • We described a case report of a 36-year-old woman with a 10-year-history of idiopathic CD4+ T-lymphocitopenia and Kaposi's sarcoma HHV8+ who developed recurrent pleural effusion.
  • Laboratory and instrumental tests with morphologic, immunophenotypic and molecular analysis of pleural sediment suggest us the diagnosis of primary effusion lymphoma (PEL).

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  • (PMID = 17566517.001).
  • [ISSN] 0009-9074
  • [Journal-full-title] La Clinica terapeutica
  • [ISO-abbreviation] Clin Ter
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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17. Brocco MA, Fernández ME, Frasch AC: Filopodial protrusions induced by glycoprotein M6a exhibit high motility and aids synapse formation. Eur J Neurosci; 2010 Jan;31(2):195-202
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  • [Title] Filopodial protrusions induced by glycoprotein M6a exhibit high motility and aids synapse formation.
  • M6a is a neuronal membrane glycoprotein whose expression diminishes during chronic stress.
  • M6a overexpression in rat primary hippocampal neurons induces the formation of filopodial protrusions that could be spine precursors.
  • As the filopodium and spine motility has been associated with synaptogenesis, we analysed the motility of M6a-induced protrusions by time-lapse imaging.
  • Our data demonstrate that the motile protrusions formed by the neurons overexpressing M6a were more abundant and moved faster than those formed in control cells.
  • When different putative M6a phosphorylation sites were mutated, the neurons transfected with a mutant lacking intracellular phosphorylation sites bore filopodia, but these protrusions did not move as fast as those formed by cells overexpressing wild-type M6a.
  • This suggests a role for M6a phosphorylation state in filopodium motility.
  • Furthermore, we show that M6a-induced protrusions could be stabilized upon contact with presynaptic region.
  • The behavior of filopodia from M6a-overexpressing cells and control cells was alike.
  • Thus, M6a-induced protrusions may be spine precursors that move to reach presynaptic membrane.
  • We suggest that M6a is a key molecule for spine formation during development.

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  • (PMID = 20074218.001).
  • [ISSN] 1460-9568
  • [Journal-full-title] The European journal of neuroscience
  • [ISO-abbreviation] Eur. J. Neurosci.
  • [Language] eng
  • [Grant] United States / Howard Hughes Medical Institute / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Gpm6a protein, rat; 0 / Membrane Glycoproteins; 0 / Nerve Tissue Proteins; 0 / Recombinant Fusion Proteins
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18. Sakuragi Y, Kolter R: Quorum-sensing regulation of the biofilm matrix genes (pel) of Pseudomonas aeruginosa. J Bacteriol; 2007 Jul;189(14):5383-6
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  • [Title] Quorum-sensing regulation of the biofilm matrix genes (pel) of Pseudomonas aeruginosa.
  • Although QS regulation of swarming and DNA release has been shown to play important roles in biofilm development, regulation of genes directly involved in biosynthesis of biofilm matrix has not been described.
  • Here, transcription of the pel operon, essential for the production of a glucose-rich matrix exopolysaccharide, is shown to be greatly reduced in lasI and rhlI mutants.
  • Chemical complementation of the lasI mutant with 3-oxo-dodecanoyl homoserine lactone restores pel transcription to the wild-type level and biofilm formation ability.
  • These findings thus connect QS signaling and transcription of genes responsible for biofilm matrix biosynthesis.

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  • (PMID = 17496081.001).
  • [ISSN] 0021-9193
  • [Journal-full-title] Journal of bacteriology
  • [ISO-abbreviation] J. Bacteriol.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM058213; United States / NIGMS NIH HHS / GM / GM58213
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins
  • [Other-IDs] NLM/ PMC1951888
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19. Wu DF, Koch T, Liang YJ, Stumm R, Schulz S, Schröder H, Höllt V: Membrane glycoprotein M6a interacts with the micro-opioid receptor and facilitates receptor endocytosis and recycling. J Biol Chem; 2007 Jul 27;282(30):22239-47
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  • [Title] Membrane glycoprotein M6a interacts with the micro-opioid receptor and facilitates receptor endocytosis and recycling.
  • Using a yeast two-hybrid screen, the neuronal membrane glycoprotein M6a, a member of the proteolipid protein family, was identified to be associated with the mu-opioid receptor (MOPr).
  • Bioluminescence resonance energy transfer and co-immunoprecipitation experiments confirmed that M6a interacts agonist-independently with MOPr in human embryonic kidney 293 cells co-expressing MOPr and M6a.
  • Co-expression of MOPr with M6a, but not with M6b or DM20, exists in many brain regions, further supporting a specific interaction between MOPr and M6a.
  • After opioid treatment M6a co-internalizes and then co-recycles with MOPr to cell surface in transfected human embryonic kidney 293 cells.
  • Moreover, the interaction of M6a and MOPr augments constitutive and agonist-dependent internalization as well as the recycling rate of mu-opioid receptors.
  • On the other hand, overexpression of a M6a-negative mutant prevents mu-opioid receptor endocytosis, demonstrating an essential role of M6a in receptor internalization.
  • In addition, we demonstrated the interaction of M6a with a number of other G protein-coupled receptors (GPCRs) such as the delta-opioid receptor, cannabinoid receptor CB1, and somatostatin receptor sst2A, suggesting that M6a might play a general role in the regulation of certain GPCRs.
  • Taken together, these data provide evidence that M6a may act as a scaffolding molecule in the regulation of GPCR endocytosis and intracellular trafficking.

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  • (PMID = 17548356.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gpm6a protein, rat; 0 / Membrane Glycoproteins; 0 / Nerve Tissue Proteins; 0 / Receptors, Opioid, mu; 0 / Recombinant Proteins
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20. Cooper B, Fuchs E, Flügge G: Expression of the axonal membrane glycoprotein M6a is regulated by chronic stress. PLoS One; 2009;4(1):e3659
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  • [Title] Expression of the axonal membrane glycoprotein M6a is regulated by chronic stress.
  • The present study shows that chronic stress also regulates expression of M6a, a glycoprotein which is localised in axonal membranes.
  • We have previously demonstrated that M6a is a component of glutamatergic axons.
  • The present data reveal that it is the splice variant M6a-Ib, not M6a-Ia, which is strongly expressed in the brain.
  • Chronic stress in male rats (3 weeks daily restraint) has regional effects: quantitative in situ hybridization demonstrated that M6a-Ib mRNA in dentate gyrus granule neurons and in CA3 pyramidal neurons is downregulated, whereas M6a-Ib mRNA in the medial prefrontal cortex is upregulated by chronic stress.
  • Enhanced M6a-Ib expression in the medial prefrontal cortex (in areas prelimbic and infralimbic cortex) might be interpreted as a compensatory mechanism in response to changes in axonal projections from the hippocampus.
  • [MeSH-major] Axons / metabolism. Brain / metabolism. Gene Expression Regulation. Membrane Glycoproteins / genetics. Nerve Tissue Proteins / genetics. Stress, Physiological / physiology
  • [MeSH-minor] Animals. Down-Regulation. Gene Expression. In Situ Hybridization. Kidney / metabolism. Male. Neurons / metabolism. Protein Isoforms. RNA, Messenger / metabolism. Rats. Rats, Sprague-Dawley. Restraint, Physical

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  • (PMID = 19180239.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gpm6a protein, rat; 0 / Membrane Glycoproteins; 0 / Nerve Tissue Proteins; 0 / Protein Isoforms; 0 / RNA, Messenger
  • [Other-IDs] NLM/ PMC2629568
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21. Sin SH, Roy D, Wang L, Staudt MR, Fakhari FD, Patel DD, Henry D, Harrington WJ Jr, Damania BA, Dittmer DP: Rapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signaling. Blood; 2007 Mar 1;109(5):2165-73
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  • [Title] Rapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signaling.
  • Primary effusion lymphoma (PEL) appears as an AIDS-defining lymphoma and like Kaposi sarcoma has been linked to Kaposi sarcoma-associated herpesvirus (KSHV).
  • We find that (1) rapamycin is efficacious against PEL in culture and in a murine xenograft model;.
  • (2) mTOR, its activator Akt, and its target p70S6 kinase are phosphorylated in PEL;.
  • This validates sirolimus as a new treatment option for PEL.

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  • (PMID = 17082322.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / HL083469; United States / NCI NIH HHS / CA / R01 CA109232; United States / NCI NIH HHS / CA / R01 CA163217; United States / NIDCR NIH HHS / DE / R01 DE018304-02; United States / NCI NIH HHS / CA / CA096500; United States / NIDCR NIH HHS / DE / DE018304-01; United States / NIDCR NIH HHS / DE / R01 DE018304; United States / NIAID NIH HHS / AI / AI057157; United States / NIDCR NIH HHS / DE / R01 DE018304-01; United States / NCI NIH HHS / CA / CA098110; United States / NCI NIH HHS / CA / CA109232; United States / NCI NIH HHS / CA / CA112935; United States / NIDCR NIH HHS / DE / R01 DE018304-03; United States / NIDCR NIH HHS / DE / DE018304-02; United States / NCI NIH HHS / CA / R01 CA098110; United States / NHLBI NIH HHS / HL / R01 HL083469; United States / NIDCR NIH HHS / DE / DE018304-03; United States / NIAID NIH HHS / AI / U54 AI057157; United States / NCI NIH HHS / CA / R01 CA096500
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cytokines; 0 / RNA, Messenger; W36ZG6FT64 / Sirolimus
  • [Other-IDs] NLM/ PMC1801055
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22. Vasseur P, Vallet-Gely I, Soscia C, Genin S, Filloux A: The pel genes of the Pseudomonas aeruginosa PAK strain are involved at early and late stages of biofilm formation. Microbiology; 2005 Mar;151(Pt 3):985-97
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The pel genes of the Pseudomonas aeruginosa PAK strain are involved at early and late stages of biofilm formation.
  • Biofilm-deficient P. aeruginosa PAK strains affected in a seven-gene cluster called pel were characterized.
  • The pel genes encode proteins with similarity to components involved in polysaccharide biogenesis, of which PelF is a putative glycosyltransferase.
  • The pel genes were previously identified in the P. aeruginosa PA14 strain as required for the production of a glucose-rich matrix material involved in the formation of a thick pellicle and resistant biofilm.
  • However, in PA14, the pel mutants have no clear phenotype in the initiation phase of attachment.
  • It was shown that pel mutations in the PAK strain had little influence on biofilm initiation but, as in PA14, appeared to generate the least robust and mature biofilms.
  • Strikingly, by constructing pel mutants in a non-piliated P. aeruginosa PAK strain, an unexpected effect of the pel mutation in the early phase of biofilm formation was discovered, since it was observed that these mutants were severely defective in the attachment process on solid surfaces.
  • The pel gene cluster is conserved in other Gram-negative bacteria, and mutation in a Ralstonia solanacearum pelG homologue, ragG, led to an adherence defect.
  • [MeSH-minor] Bacterial Adhesion. Culture Media. DNA Transposable Elements. Gene Expression Regulation, Bacterial. Glycosyltransferases / genetics. Glycosyltransferases / metabolism. Hydrophobic and Hydrophilic Interactions. Multigene Family. Mutation. Polysaccharides, Bacterial / genetics. Polysaccharides, Bacterial / metabolism

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  • (PMID = 15758243.001).
  • [ISSN] 1350-0872
  • [Journal-full-title] Microbiology (Reading, England)
  • [ISO-abbreviation] Microbiology (Reading, Engl.)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Culture Media; 0 / DNA Transposable Elements; 0 / Polysaccharides, Bacterial; EC 2.4.- / Glycosyltransferases
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23. Alarcon F, Bourgain C, Gauthier-Villars M, Planté-Bordeneuve V, Stoppa-Lyonnet D, Bonaïti-Pellié C: PEL: an unbiased method for estimating age-dependent genetic disease risk from pedigree data unselected for family history. Genet Epidemiol; 2009 Jul;33(5):379-85
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  • [Title] PEL: an unbiased method for estimating age-dependent genetic disease risk from pedigree data unselected for family history.
  • Providing valid risk estimates of a genetic disease with variable age of onset is a major challenge for prevention strategies.
  • This article focuses on ascertainment through at least one affected and presents an estimation method based on maximum likelihood, called the Proband's phenotype exclusion likelihood or PEL for estimating age-dependent penetrance using disease status and genotypic information of family members in pedigrees unselected for family history.
  • We studied the properties of the PEL and compared with another method, the prospective likelihood, in terms of bias and efficiency in risk estimate.
  • For that purpose, family samples were simulated under various disease risk models and under various ascertainment patterns.
  • We showed that, whatever the genetic model and the ascertainment scheme, the PEL provided unbiased estimates, whereas the prospective likelihood exhibited some bias in a number of situations.
  • As an illustration, we estimated the disease risk for transthyretin amyloid neuropathy from a French sample and a Portuguese sample and for BRCA1/2 associated breast cancer from a sample ascertained on early-onset breast cancer cases.
  • [MeSH-minor] Age Factors. Amyloid Neuropathies / genetics. Bias (Epidemiology). Breast Neoplasms / genetics. France. Genes, BRCA1. Genes, BRCA2. Humans. Likelihood Functions. Models, Genetic. Models, Statistical. Pedigree. Phenotype. Portugal. Prealbumin / genetics. Risk

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  • [Copyright] 2008 Wiley-Liss, Inc.
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  • (PMID = 19089844.001).
  • [ISSN] 1098-2272
  • [Journal-full-title] Genetic epidemiology
  • [ISO-abbreviation] Genet. Epidemiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Prealbumin
  • [Other-IDs] NLM/ HALMS358140; NLM/ PMC3108000
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24. Alfonso J, Fernández ME, Cooper B, Flugge G, Frasch AC: The stress-regulated protein M6a is a key modulator for neurite outgrowth and filopodium/spine formation. Proc Natl Acad Sci U S A; 2005 Nov 22;102(47):17196-201
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  • [Title] The stress-regulated protein M6a is a key modulator for neurite outgrowth and filopodium/spine formation.
  • We have recently identified the glycoprotein M6a as a stress-responsive gene in the hippocampal formation.
  • This gene is down-regulated in the hippocampus of both socially and physically stressed animals, and this effect can be reversed by antidepressant treatment.
  • In the present work, we analyzed the biological function of the M6a protein.
  • Immunohistochemistry showed that the M6a protein is abundant in all hippocampal subregions, and subcellular analysis in primary hippocampal neurons revealed its presence in membrane protrusions (filopodia/spines).
  • Transfection experiments revealed that M6a overexpression induces neurite formation and increases filopodia density in hippocampal neurons.
  • M6a knockdown with small interference RNA methodology showed that M6a low-expressing neurons display decreased filopodia number and a lower density of synaptophysin clusters.
  • Taken together, our findings indicate that M6a plays an important role in neurite/filopodium outgrowth and synapse formation.
  • Therefore, reduced M6a expression might be responsible for the morphological alterations found in the hippocampus of chronically stressed animals.
  • Potential mechanisms that might explain the biological effects of M6a are discussed.

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  • (PMID = 16286650.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gpm6a protein, rat; 0 / Membrane Glycoproteins; 0 / Nerve Tissue Proteins; 0 / RNA, Small Interfering
  • [Other-IDs] NLM/ PMC1287971
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25. Ueda A, Wood TK: Connecting quorum sensing, c-di-GMP, pel polysaccharide, and biofilm formation in Pseudomonas aeruginosa through tyrosine phosphatase TpbA (PA3885). PLoS Pathog; 2009 Jun;5(6):e1000483
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  • [Title] Connecting quorum sensing, c-di-GMP, pel polysaccharide, and biofilm formation in Pseudomonas aeruginosa through tyrosine phosphatase TpbA (PA3885).
  • This screen identified the PA3885 mutant, which had 147-fold more biofilm than the wild-type strain.
  • Whole transcriptome analysis showed that loss of PA3885 activated expression of the pel locus, an operon that encodes for the synthesis of extracellular matrix polysaccharide.
  • Genetic screening identified that loss of PelABDEG and the PA1120 protein (which contains a GGDEF-motif) suppressed the phenotypes of the PA3885 mutant, suggesting that the function of the PA3885 protein is to regulate 3,5-cyclic diguanylic acid (c-di-GMP) concentrations as a phosphatase since c-di-GMP enhances biofilm formation by activating PelD, and c-di-GMP inhibits swarming.
  • Loss of PA3885 protein increased cellular c-di-GMP concentrations; hence, PA3885 protein is a negative regulator of c-di-GMP production.
  • Las-mediated quorum sensing positively regulates expression of the PA3885 gene.
  • These results show that the PA3885 protein responds to AHL signals and likely dephosphorylates PA1120, which leads to reduced c-di-GMP production.
  • This inhibits matrix exopolysaccharide formation, which leads to reduced biofilm formation; hence, we provide a mechanism for quorum sensing control of biofilm formation through the pel locus and suggest PA3885 should be named TpbA for tyrosine phosphatase related to biofilm formation and PA1120 should be TpbB.

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  • (PMID = 19543378.001).
  • [ISSN] 1553-7374
  • [Journal-full-title] PLoS pathogens
  • [ISO-abbreviation] PLoS Pathog.
  • [Language] ENG
  • [Grant] United States / NIBIB NIH HHS / EB / R01 EB003872
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adhesins, Bacterial; 0 / Bacterial Proteins; 0 / Glycolipids; 0 / Polysaccharides, Bacterial; 0 / rhamnolipid; 42HK56048U / Tyrosine; 61093-23-0 / bis(3',5')-cyclic diguanylic acid; EC 3.1.3.48 / Protein Tyrosine Phosphatases; H2D2X058MU / Cyclic GMP
  • [Other-IDs] NLM/ PMC2691606
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26. Wong SS, Thomas A, Barbaris B, Lantz RC, Witten ML: Pulmonary evaluation of permissible exposure limit of syntroleum S-8 synthetic jet fuel in mice. Toxicol Sci; 2009 Jun;109(2):312-20
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  • [Title] Pulmonary evaluation of permissible exposure limit of syntroleum S-8 synthetic jet fuel in mice.
  • No significant changes in respiratory permeability were exhibited, indicating that there was no loss of epithelial barrier integrity following S-8 exposure.
  • However, morphological examination and morphometric analysis of distal lung tissue, by using transmission electron microscopy, revealed cellular damage in alveolar type II epithelial cells, with significant increases in volume density of lamellar bodies/vacuoles at 352 and 616 S-8 mg/m(3).
  • Moreover, terminal bronchiolar Clara injury, as evidenced by apical membrane blebs, was observed at relatively low concentrations, suggesting if this synthetic jet fuel is utilized, the current permissible exposure limit of 350 mg/m(3) for hydrocarbon fuels should cautiously be applied.

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  • (PMID = 19357071.001).
  • [ISSN] 1096-0929
  • [Journal-full-title] Toxicological sciences : an official journal of the Society of Toxicology
  • [ISO-abbreviation] Toxicol. Sci.
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / P30 ES006694; United States / NIEHS NIH HHS / ES / ES06694
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hydrocarbons; 0 / S-8 fuel
  • [Other-IDs] NLM/ PMC2683924
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27. Arguello M, Paz S, Hernandez E, Corriveau-Bourque C, Fawaz LM, Hiscott J, Lin R: Leukotriene A4 hydrolase expression in PEL cells is regulated at the transcriptional level and leads to increased leukotriene B4 production. J Immunol; 2006 Jun 1;176(11):7051-61
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  • [Title] Leukotriene A4 hydrolase expression in PEL cells is regulated at the transcriptional level and leads to increased leukotriene B4 production.
  • Primary effusion lymphoma (PEL) is a herpesvirus-8-associated lymphoproliferative disease characterized by migration of tumor cells to serous body cavities.
  • PEL cells originate from postgerminal center B cells and share a remarkable alteration in B cell transcription factor expression and/or activation with classical Hodgkin's disease cells.
  • Comparative analysis of gene expression by cDNA microarray of BCBL-1 cells (PEL), L-428 (classical Hodgkin's disease), and BJAB cells revealed a subset of genes that were differentially expressed in BCBL-1 cells.
  • Among these, four genes involved in cell migration and chemotaxis were strongly up-regulated in PEL cells: leukotriene A4 (LTA4) hydrolase (LTA4H), IL-16, thrombospondin-1 (TSP-1), and selectin-P ligand (PSGL-1).
  • Up-regulation of LTA4H was investigated at the transcriptional level.
  • Formation of a specific DNA-protein complex in this region was confirmed by EMSA.
  • [MeSH-minor] Cell Line, Tumor. Enzyme Activation / genetics. Gene Expression Profiling. Hodgkin Disease / genetics. Humans. Inflammation / genetics. Inflammation / immunology. Interleukin-16 / physiology. Membrane Glycoproteins / biosynthesis. Membrane Glycoproteins / genetics. Membrane Glycoproteins / physiology. Promoter Regions, Genetic. RNA, Messenger / biosynthesis. Thrombospondin 1 / biosynthesis. Thrombospondin 1 / genetics. Thrombospondin 1 / physiology. Transcription, Genetic

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  • (PMID = 16709867.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interleukin-16; 0 / Membrane Glycoproteins; 0 / P-selectin ligand protein; 0 / RNA, Messenger; 0 / Thrombospondin 1; 1HGW4DR56D / Leukotriene B4; EC 3.3.2.- / Epoxide Hydrolases; EC 3.3.2.- / leukotriene A4 hydrolase
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28. Ueda K, Ito E, Karayama M, Ohsaki E, Nakano K, Watanabe S: KSHV-infected PEL cell lines exhibit a distinct gene expression profile. Biochem Biophys Res Commun; 2010 Apr 9;394(3):482-7
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  • [Title] KSHV-infected PEL cell lines exhibit a distinct gene expression profile.
  • We analyzed the gene expression profiles of lymphocyte-originated tumor cell lines - primary effusion lymphoma (PEL) cell lines, T-cell leukemia (TCL) cell lines, Burkitt lymphoma (BL) cell lines - and two sets of normal peripheral blood mononuclear cells (PBMCs) - in order to determine characteristic gene expression profiles for each of the former three groups.
  • And we found that these cell lines showed respective typical gene expression profiles and classified into clear four groups, PEL, TCL, BL, and normal PBMCs.
  • Two B lymphocyte-originated tumor cell lines, PEL and BL cell lines, clearly exhibited distinct gene expression profiles, respectively.
  • Even though there was only one line that was co-infected with both Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV), KSHV seemed to govern the gene expression profile of the co-infected line.
  • These data suggested not only that established typical tumor cell lines show a distinct gene expression profile but also that this profile may be governed by certain viruses.
  • [MeSH-major] Gene Expression Regulation, Neoplastic. Gene Expression Regulation, Viral. Herpesvirus 8, Human. Lymphoma, Primary Effusion / genetics. Lymphoma, Primary Effusion / virology
  • [MeSH-minor] Angiopoietin-1 / genetics. Cell Line, Tumor. Gene Expression Profiling. Humans

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20175997.001).
  • [ISSN] 1090-2104
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiopoietin-1
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29. Radlińska M, Piekarowicz A, Galimand M, Bujnicki JM: Cloning and preliminary characterization of a GATC-specific beta2-class DNA:m6A methyltransferase encoded by transposon Tn1549 from Enterococcus spp. Pol J Microbiol; 2005;54(3):249-52
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  • [Title] Cloning and preliminary characterization of a GATC-specific beta2-class DNA:m6A methyltransferase encoded by transposon Tn1549 from Enterococcus spp.
  • A recent study revealed a subfamily of N6-adenine (m6A) methyltransferases that comprises a few functionally studied eukaryotic members acting on mRNA and prokaryotic members acting on DNA as well as numerous uncharacterized open reading frames.
  • Here, we report cloning and functional characterization of a prokaryotic member of this family encoded by transposon Tn1549 from Enterococcus spp.

  • REBASE - The Restriction Enzyme Database. gene/protein/disease-specific - REBASE ref# 9191 .
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  • (PMID = 16450842.001).
  • [ISSN] 1733-1331
  • [Journal-full-title] Polish journal of microbiology
  • [ISO-abbreviation] Pol. J. Microbiol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / DNA Transposable Elements; 0 / DNA, Bacterial; EC 2.1.1.72 / Site-Specific DNA-Methyltransferase (Adenine-Specific)
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30. Metaxa-Mariatou V, Papaioannou D, Loli A, Papadopoulou I, Gazouli M, Mavroudis P, Nasioulas G: Subtype C1 persistent infection of HHV-8 in a PEL patient. Leuk Lymphoma; 2005 Oct;46(10):1507-12
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  • [Title] Subtype C1 persistent infection of HHV-8 in a PEL patient.
  • PEL, a rare type of lymphoma constituting less than 5% of NHLs, has been recently identified as a distinct clinical and pathological entity among the B-cell lymphomas, with characteristic morphologic, immunophenotypic, molecular and viral features.
  • Using a combination of clinical, morphological, immunohistochemical features and molecular biology techniques in this study we document a PEL case with persistent HHV-8 of genotype C1 infection.
  • [MeSH-minor] Adult. Amino Acid Sequence. Base Sequence. Follow-Up Studies. Genotype. Greece / ethnology. Hodgkin Disease. Humans. Male. Molecular Sequence Data. Phylogeny. Sequence Alignment. Viral Proteins / chemistry. Viral Proteins / genetics

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  • (PMID = 16194897.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / K1 protein, Human herpesvirus 8; 0 / Viral Proteins
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31. Liao CH, Fett W, Tzean SS, Hoffman G: Detection and sequence analysis of an altered pectate lyase gene in Pseudomonas syringae pv. glycinea and related bacteria. Can J Microbiol; 2006 Nov;52(11):1051-9
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  • [Title] Detection and sequence analysis of an altered pectate lyase gene in Pseudomonas syringae pv. glycinea and related bacteria.
  • Pectate lyase (PL) is a potent cell wall-degrading enzyme known to play a role in the microbial infection of plants.
  • However, the PL gene (pel) was detected by Southern hybridization in four out of four P. syringae pv. glycinea strains examined.
  • A P. syringae pv. glycinea pel gene was cloned, sequenced, and predicted to encode a protein sharing 70%-90% identity in amino acid sequence with PLs produced by pectolytic pseudomonads and xanthomonads.
  • A series of amino acid and nucleotide sequence analyses reveal that (i) the predicted P. syringae pv. glycinea PL contains two regions in the amino acid sequence that may affect the formation of a beta-helix structure important for the enzyme activity, and (ii) the P. syringae pv. glycinea pel gene contains a single-base insertion, a double-base insertion, and an 18-bp deletion, which can lead to the synthesis of an inactive PL protein.
  • The altered pel sequence was also detected by polymerase chain reaction and nucleotide sequencing in the genomes of other pathovars of P. syringae, including phaseolicola and tagetis.

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  • (PMID = 17215896.001).
  • [ISSN] 0008-4166
  • [Journal-full-title] Canadian journal of microbiology
  • [ISO-abbreviation] Can. J. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] EC 4.2.2.- / Polysaccharide-Lyases; EC 4.2.2.2 / pectate lyase
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32. Lautier T, Blot N, Muskhelishvili G, Nasser W: Integration of two essential virulence modulating signals at the Erwinia chrysanthemi pel gene promoters: a role for Fis in the growth-phase regulation. Mol Microbiol; 2007 Dec;66(6):1491-505
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  • [Title] Integration of two essential virulence modulating signals at the Erwinia chrysanthemi pel gene promoters: a role for Fis in the growth-phase regulation.
  • Production of the essential virulence factors, called pectate lyases (Pels), in the phytopathogenic bacterium Erwinia chrysanthemi is controlled by a complex regulation system and responds to various stimuli, such as the presence of pectin or plant extracts, growth phase, temperature and iron concentration.
  • Eight regulators modulating the expression of the pel genes (encoding Pels) have been characterized.
  • Although many studies have been carried out, the mechanisms of control of Pel production by growth phase have not yet been elucidated.
  • Here we report that a fis mutant of E. chrysanthemi showed a strong increase in transcription of the pel genes during exponential growth whereas induction of expression in the parental strain occurred at the end of exponential growth.
  • This reveals that Fis acts to prevent an efficient transcription of pel genes at the beginning of exponential growth and also provides evidence of the involvement of Fis in the growth-phase regulation of the pel genes.
  • By using in vitro DNA-protein interactions and transcription experiments, we find that Fis directly represses the pel gene expression at the transcription initiation step.
  • In addition, we show that Fis acts in concert with KdgR, the main repressor responding to the presence of pectin compounds, to shut down the pel gene transcription.

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  • (PMID = 18028312.001).
  • [ISSN] 0950-382X
  • [Journal-full-title] Molecular microbiology
  • [ISO-abbreviation] Mol. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / KdgR protein, Erwinia chrysanthemi; 0 / Repressor Proteins; 0 / Transcription Factors; 9007-49-2 / DNA; EC 4.2.2.- / PelE protein, Erwinia chrysanthemi; EC 4.2.2.- / Polysaccharide-Lyases; EC 4.2.2.2 / pectate lyase
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33. Santiago-Doménech N, Jiménez-Bemúdez S, Matas AJ, Rose JK, Muñoz-Blanco J, Mercado JA, Quesada MA: Antisense inhibition of a pectate lyase gene supports a role for pectin depolymerization in strawberry fruit softening. J Exp Bot; 2008;59(10):2769-79
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  • [Title] Antisense inhibition of a pectate lyase gene supports a role for pectin depolymerization in strawberry fruit softening.
  • It has been reported previously that inhibiting the expression of pectate lyase genes by antisense technology in strawberry (Fragaria x ananassa Duch.) fruit resulted in prolonged fruit firmness.
  • In this present study, three independent transgenic lines were identified exhibiting a greater than 90% reduction in pectate lyase transcript abundance.
  • These results indicate that pectate lyase plays an important degradative role in the primary wall and middle lamella in ripening strawberry fruit, and should be included in synergistic models of cell wall disassembly.

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  • (PMID = 18522930.001).
  • [ISSN] 1460-2431
  • [Journal-full-title] Journal of experimental botany
  • [ISO-abbreviation] J. Exp. Bot.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Pectins; 0 / Plant Proteins; 9000-69-5 / pectin; EC 4.2.2.- / Polysaccharide-Lyases; EC 4.2.2.2 / pectate lyase
  • [Other-IDs] NLM/ PMC2486476
  • [Keywords] NOTNLM ; Cell wall / Fragaria / fruit ripening / pectate lyase / pectinases / strawberry
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34. Palusa SG, Golovkin M, Shin SB, Richardson DN, Reddy AS: Organ-specific, developmental, hormonal and stress regulation of expression of putative pectate lyase genes in Arabidopsis. New Phytol; 2007;174(3):537-50
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  • [Title] Organ-specific, developmental, hormonal and stress regulation of expression of putative pectate lyase genes in Arabidopsis.
  • Pectate lyases catalyse the eliminative cleavage of de-esterified homogalacturonan in pectin, a major component of the primary cell walls in higher plants.
  • In the completed genome of Arabidopsis, there are 26 genes (AtPLLs) that encode pectate lyase-like proteins.
  • Interestingly, all PLL genes are expressed in flowers.
  • Analysis of expression of all PLL genes in seedlings treated with hormones, abiotic stresses and elicitors of defense responses revealed significant changes in the expression of some PLLs without affecting the other PLLs.
  • The stability of transcripts of PLLs varied considerably among different genes.
  • [MeSH-major] Arabidopsis / genetics. Arabidopsis Proteins / genetics. Gene Expression Regulation, Plant. Polysaccharide-Lyases / genetics

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  • (PMID = 17447910.001).
  • [ISSN] 0028-646X
  • [Journal-full-title] The New phytologist
  • [ISO-abbreviation] New Phytol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Arabidopsis Proteins; 0 / Deoxyadenosines; 0 / RNA, Messenger; 73-03-0 / cordycepin; EC 4.2.2.- / Polysaccharide-Lyases; EC 4.2.2.2 / pectate lyase
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35. Cohen R, Steinmaus C, Quinlan P, Ku R, Cooper M, Roberts T: Development of permissible exposure limits: the California experience. Int J Occup Environ Health; 2006 Jul-Sep;12(3):242-7
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  • [Title] Development of permissible exposure limits: the California experience.
  • The California OSHA Airborne Contaminant Advisory Committee reviewed several hundred substances and recommended occupational exposure limits with the intent of worker and employer protection.
  • [MeSH-major] Advisory Committees / organization & administration. Hazardous Substances / standards. Occupational Exposure / standards. Occupational Health / legislation & jurisprudence
  • [MeSH-minor] Animals. California. Communication. Humans. Maximum Allowable Concentration. National Institute for Occupational Safety and Health (U.S.) / standards. No-Observed-Adverse-Effect Level. Program Development. United States

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  • (PMID = 16967831.001).
  • [ISSN] 1077-3525
  • [Journal-full-title] International journal of occupational and environmental health
  • [ISO-abbreviation] Int J Occup Environ Health
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hazardous Substances
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36. Srinivas U, Kumar R, Pati H, Saxena R, Tyagi S: Sub classification and clinico-hematological correlation of 40 cases of acute erythroleukemia - can proerythroblast/myeloblast and proerythroblast/total erythroid cell ratios help subclassify? Hematology; 2007 Oct;12(5):381-5
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  • [Title] Sub classification and clinico-hematological correlation of 40 cases of acute erythroleukemia - can proerythroblast/myeloblast and proerythroblast/total erythroid cell ratios help subclassify?
  • The clinico-hematological profile of 40 cases of acute erythroleukemia (AEL) was evaluated.
  • These were subclassified into three types, namely AML M6a, M6b and M6c based on the myeloblast and proerythroblast percentages.
  • As AEL is biologically an "erythroid predominant" disease, two ratios (PE/MB, PE/TEC) with proerythroblasts as numerator have been formulated.
  • An attempt has been made to assess the difference in these ratios in subclassified AEL.
  • There were 29 M6a, 2M6b,and 9 M6 c patients, which were subclassified using the criteria proposed by Mazzella et al.
  • The incidence of AEL in our study was 3.7%, predominantly affecting males with a predilection to younger age in contrast to Western studies.
  • Both PE/MB and PE/TEC ratios were higher in M6b and M6c in comparison to M6a.
  • The subclassification of AEL becomes essential especially in the era of lineage-targeted therapies, which can lead to the development and use of erythroid specific treatments in the near future.
  • [MeSH-major] Leukemia, Erythroblastic, Acute / classification
  • [MeSH-minor] Adult. Age Factors. Aged. Cell Count. Erythroblasts. Erythroid Cells. Female. Granulocyte Precursor Cells. Humans. Incidence. Male. Middle Aged. Sex Factors

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  • (PMID = 17852448.001).
  • [ISSN] 1607-8454
  • [Journal-full-title] Hematology (Amsterdam, Netherlands)
  • [ISO-abbreviation] Hematology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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37. Abraham SK, Schupp N, Schmid U, Stopper H: Antigenotoxic effects of the phytoestrogen pelargonidin chloride and the polyphenol chlorogenic acid. Mol Nutr Food Res; 2007 Jul;51(7):880-7
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  • Pelargonidin (PEL), a common anthocyanidin with estrogenic activity, was tested in HL-60 cells for its genotoxicity and possible antigenotoxic effects against 4-nitroquinoline 1-oxide (NQO), a potent mutagen and carcinogen which induces oxidative stress.
  • To take into account potential interactions between phytochemicals within normal human nutrition, we evaluated a combination of PEL with the nonestrogenic phytochemical chlorogenic acid (CLA), one of the most abundant polyphenols in the human diet.
  • PEL (< or = 2 microM) and CLA (< or = 800 microM) were nongenotoxic in the micronucleus test.
  • We observed significant antigenotoxic effects against NQO with both compounds, but no additive interaction of PEL and CLA.
  • Flow cytometric analysis of oxidative stress revealed significant protection against NQO-induced oxidative stress by PEL, CLA, and their combination.
  • Furthermore, PEL and CLA prevented the NQO-induced reduction in GSH level.
  • In conclusion, the phytoestrogen PEL revealed antioxidative and antigenotoxic properties in HL-60 cells, but no significant additive interaction with the abundant nutritional polyphenol CLA under the tested conditions.

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  • (PMID = 17579891.001).
  • [ISSN] 1613-4125
  • [Journal-full-title] Molecular nutrition & food research
  • [ISO-abbreviation] Mol Nutr Food Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anthocyanins; 0 / Antimutagenic Agents; 0 / Mutagens; 0 / Phytoestrogens; 318ADP12RI / Chlorogenic Acid; 56-57-5 / 4-Nitroquinoline-1-oxide; 7690-51-9 / pelargonidin
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38. Gloux K, Touze T, Pagot Y, Jouan B, Blanco C: Mutations of ousA alter the virulence of Erwinia chrysanthemi. Mol Plant Microbe Interact; 2005 Feb;18(2):150-7
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  • The disruption of the ousA gene encoding the major osmoprotectant uptake system highly enhanced bacterial virulence on potato tubers.
  • In the absence of oxygen, pectate lyase (Pel) production was significantly higher in the tissue macerated with the ousA- strain than with the wild type.
  • In minimal medium, ousA disruption enhanced Pel production and pelE expression only under micro-aerobiosis conditions.
  • The effect on Pel was reversed by reintroduction of the ousA gene.
  • The osmoprotectectants glycine betaine, proline betaine, and pipecolic acid are known to be taken up via OusA and to have an inhibitory effect on Pel production.
  • However, their effects on Pel activity were not (glycine betaine) or only weakly (proline and pipecolic acid) affected by ousA disruption.
  • Furthermore, no correlation was observed between their effects on Pel activities and their osmoprotection efficacies.
  • The evidence indicates that ousA and osmoprotectant effects on Pel are not linked to osmoregulation and that complex regulations exist between Pel production, ousA, and osmoprotection via compounds liberated during the plant infection.
  • [MeSH-minor] Gene Expression Regulation, Bacterial / physiology. Osmosis. Oxygen. Plant Tubers / microbiology. Polysaccharide-Lyases / biosynthesis. Polysaccharide-Lyases / metabolism. Solanum tuberosum / microbiology. Virulence / genetics

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  • (PMID = 15720084.001).
  • [ISSN] 0894-0282
  • [Journal-full-title] Molecular plant-microbe interactions : MPMI
  • [ISO-abbreviation] Mol. Plant Microbe Interact.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Membrane Transport Proteins; 0 / OusA protein, Erwinia chrysanthemi; EC 4.2.2.- / PelE protein, Erwinia chrysanthemi; EC 4.2.2.- / Polysaccharide-Lyases; EC 4.2.2.2 / pectate lyase; S88TT14065 / Oxygen
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39. Wong SS, Vargas J, Thomas A, Fastje C, McLaughlin M, Camponovo R, Lantz RC, Heys J, Witten ML: In vivo comparison of epithelial responses for S-8 versus JP-8 jet fuels below permissible exposure limit. Toxicology; 2008 Dec 5;254(1-2):106-11
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  • [Title] In vivo comparison of epithelial responses for S-8 versus JP-8 jet fuels below permissible exposure limit.
  • This study was designed to characterize and compare the pulmonary effects in distal lung from a low-level exposure to jet propellant-8 fuel (JP-8) and a new synthetic-8 fuel (S-8).
  • A pulmonary function test performed 24h after the final exposure indicated that there was a significant increase in expiratory lung resistance in the S-8 mice, whereas JP-8 mice had significant increases in both inspiratory and expiratory lung resistance compared to control values.

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  • (PMID = 18930109.001).
  • [ISSN] 0300-483X
  • [Journal-full-title] Toxicology
  • [ISO-abbreviation] Toxicology
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / ES006694-14; United States / NIEHS NIH HHS / ES / P30 ES006694; United States / NIEHS NIH HHS / ES / ES06694; United States / NIEHS NIH HHS / ES / P30 ES006694-14
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Hydrocarbons; 0 / JP8 aviation fuel; 0 / S-8 fuel
  • [Other-IDs] NLM/ NIHMS208577; NLM/ PMC2927360
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40. Fernández ME, Alfonso J, Brocco MA, Frasch AC: Conserved cellular function and stress-mediated regulation among members of the proteolipid protein family. J Neurosci Res; 2010 May 1;88(6):1298-308
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  • We have previously identified M6a as a stress responsive gene and shown that M6a is involved in filopodium/spine outgrowth and, likely, synapse formation.
  • M6a belongs to the proteolipid protein (PLP) family, all of their members having four transmembrane domains that allow their localization at the plasma membrane.
  • In the present work, we analyzed other members of this family, the closely related M6b as well as PLP and its splice variant DM20.
  • We found that chronic restraint stress in mice reduces M6b and DM20, but not PLP, mRNA levels in the hippocampus.
  • In addition, M6b and DM20, but again not PLP, induce filopodium formation in primary cultures of hippocampal neurons.
  • Several M6b protein isoforms were studied, all of them having similar effects except for the one lacking the transmembrane domains.
  • [MeSH-minor] Animals. COS Cells. Cell Line, Tumor. Cells, Cultured. Cercopithecus aethiops. Chronic Disease. Disease Models, Animal. Male. Membrane Glycoproteins / metabolism. Mice. Mice, Inbred C57BL. Myelin Proteolipid Protein / metabolism. Nerve Tissue Proteins / metabolism. Protein Isoforms / metabolism. RNA, Messenger / metabolism. Restraint, Physical

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19937804.001).
  • [ISSN] 1097-4547
  • [Journal-full-title] Journal of neuroscience research
  • [ISO-abbreviation] J. Neurosci. Res.
  • [Language] eng
  • [Grant] United States / Howard Hughes Medical Institute / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gpm6a protein, mouse; 0 / Membrane Glycoproteins; 0 / Myelin Proteolipid Protein; 0 / Nerve Tissue Proteins; 0 / Plp1 protein, mouse; 0 / Protein Isoforms; 0 / Proteolipids; 0 / RNA, Messenger
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41. Wong EL, Damania B: Linking KSHV to human cancer. Curr Oncol Rep; 2005 Sep;7(5):349-56
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  • KSHV is the etiologic agent associated with the development of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD).
  • Here, we review the association of KSHV with human cancer, viral genes that may potentially be involved in the neoplastic process, and current therapies used to treat KS, PEL, and MCD.
  • [MeSH-minor] Animals. Biopsy. Cell Transformation, Neoplastic. Cytokines / metabolism. Genes, Viral. Genome, Viral. Giant Lymph Node Hyperplasia / therapy. Giant Lymph Node Hyperplasia / virology. Humans. Lymphoma / therapy. Lymphoma / virology. Sarcoma, Kaposi / therapy. Sarcoma, Kaposi / virology

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  • (PMID = 16091195.001).
  • [ISSN] 1523-3790
  • [Journal-full-title] Current oncology reports
  • [ISO-abbreviation] Curr Oncol Rep
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / 5T32AI007001; United States / NCI NIH HHS / CA / CA096500
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cytokines
  • [Number-of-references] 80
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42. Kitagawa J, Hara T, Tsurumi H, Oyama M, Moriwaki H: Pure erythroid leukemia with hemophagocytosis. Intern Med; 2009;48(18):1695-8
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  • [Title] Pure erythroid leukemia with hemophagocytosis.
  • Biochemistry showed increased ferritin levels.
  • Pure erythroid leukemia with hemophagocytic syndrome (HPS) was diagnosed.
  • Complete remission was attained, and HPS also improved.
  • However, leukemia relapsed during chemotherapy and the patient died.
  • This is the first report of pure erythroid leukemia complicated with HPS.
  • [MeSH-major] Leukemia, Erythroblastic, Acute / complications. Lymphohistiocytosis, Hemophagocytic / etiology

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  • (PMID = 19755777.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 04079A1RDZ / Cytarabine; X4W7ZR7023 / Methylprednisolone; ZRP63D75JW / Idarubicin
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43. Boulanger E, Meignin V, Afonso PV, Duprez R, Oksenhendler E, Agbalika F, Gessain A: Extracavitary tumor after primary effusion lymphoma: relapse or second distinct lymphoma? Haematologica; 2007 Sep;92(9):1275-6
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  • HHV-8-associated solid lymphomas which develop in extracavitary sites during the course of primary effusion lymphoma (PEL) could represent the relapse of original PEL tumors in different anatomical sites, or newly occurring distinct HHV-8-associated lymphomas, such as multicentric Castleman disease-related microlymphomas.
  • [MeSH-major] Herpesviridae Infections / complications. Herpesvirus 8, Human / isolation & purification. Lymphoma / complications. Lymphoma, AIDS-Related / complications. Neoplasm Recurrence, Local / complications. Pleural Effusion, Malignant / complications

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  • (PMID = 17768127.001).
  • [ISSN] 1592-8721
  • [Journal-full-title] Haematologica
  • [ISO-abbreviation] Haematologica
  • [Language] eng
  • [Publication-type] Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
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44. Snozek CL, Saenger AK, Greipp PR, Bryant SC, Kyle RA, Rajkumar SV, Katzmann JA: Comparison of bromcresol green and agarose protein electrophoresis for quantitation of serum albumin in multiple myeloma. Clin Chem; 2007 Jun;53(6):1099-103
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  • Two common albumin assays, bromcresol green (BCG) and agarose gel protein electrophoresis (PEL), frequently yield discordant results, creating confusion regarding which assay is superior for use in myeloma.
  • METHODS: We measured albumin by BCG on a Roche Modular system, by PEL with a Helena SPIFE SPE Vis agarose gel, and by immunonephelometry performed on a Dade Behring BNII nephelometer.
  • BCG and PEL were used to measure albumin in 5777 patient samples, and all 3 methods were used in an additional 252 samples.
  • RESULTS: For sera with zero/low monoclonal immunoglobulin protein (M)-spike (0 to <15 g/L), results for both BCG and PEL correlated well to nephelometry, although median PEL results were 8 g/L lower than corresponding BCG measurements.
  • Correlation between PEL and nephelometry or BCG diminished with increasing M-spike, with PEL eventually overestimating albumin compared with both other assays.
  • For 35% of myeloma patients, discrepancy between BCG and PEL had a potentially clinically significant effect on staging, but no difference in group survival was found.
  • CONCLUSIONS: Both BCG and PEL correlate well to nephelometry in sera with zero/low M-spikes.
  • In the presence of larger M-spikes, PEL correlates poorly to nephelometry or BCG, whereas BCG compares well with nephelometry regardless of M-spike.
  • [MeSH-major] Bromcresol Green. Multiple Myeloma / diagnosis. Serum Albumin / analysis

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  • (PMID = 17463172.001).
  • [ISSN] 0009-9147
  • [Journal-full-title] Clinical chemistry
  • [ISO-abbreviation] Clin. Chem.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA62242
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Indicators and Reagents; 0 / Paraproteins; 0 / Serum Albumin; 8YGN0Y942M / Bromcresol Green
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45. Zhuge B, Du GC, Shen W, Zhuge J, Chen J: Efficient secretory expression of an alkaline pectate lyase gene from Bacillus subtilis in E. coli and the purification and characterization of the protein. Biotechnol Lett; 2007 Mar;29(3):405-10
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  • [Title] Efficient secretory expression of an alkaline pectate lyase gene from Bacillus subtilis in E. coli and the purification and characterization of the protein.
  • The gene encoding pectate lyase (PL) from Bacillus subtilis WSHB04-02 was amplified by PCR, fused with a periplasmic secretion signal peptide sequence, pelB, from pET22b(+), cloned and expressed in Escherichia coli cells using a temperature control vector, pHsh.
  • [MeSH-minor] Enzyme Activation. Enzyme Stability. Gene Expression Regulation, Bacterial / physiology. Gene Expression Regulation, Enzymologic / physiology. Genetic Enhancement / methods. Recombinant Proteins / biosynthesis. Recombinant Proteins / chemistry

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  • (PMID = 17237974.001).
  • [ISSN] 1573-6776
  • [Journal-full-title] Biotechnology letters
  • [ISO-abbreviation] Biotechnol. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Recombinant Proteins; EC 4.2.2.- / Polysaccharide-Lyases; EC 4.2.2.2 / pectate lyase
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46. Suzuki K, Ino K, Sugawara Y, Mizutani M, Sekine T, Katayama N: [Prolonged survival in a patient with human herpesvirus-8-negative primary effusion lymphoma after combination chemotherapy with rituximab]. Gan To Kagaku Ryoho; 2008 Apr;35(4):691-4
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  • Primary effusion lymphoma (PEL) is a unique clinicopathological entity usually associated with human herpesvirus-8 (HHV-8) infection.
  • We presented a rare case of HIV-negative PEL in an elderly HHV-8-negative patient who developed cardiac tamponade due to pericardial effusion.
  • This disease generally has a poor prognosis; however, this patient achieved complete remission and remains without signs of disease 30 months after the last treatment.
  • Because most HIV-negative and HHV-8- negative PEL cases show pan-B-cell markers, there is considerable usage of rituximab, though its optimal usage for PEL is unclear.
  • To the best of our knowledge, there have been five reported cases where rituximab treatment has been used against HIV-negative and HHV-8-negative PEL.
  • HIV-negative and HHV-8-negative PEL appears to be a reasonably new clinicopathological entity.

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  • (PMID = 18408447.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 4F4X42SYQ6 / Rituximab
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47. Cai SL, Lin JH, Wang CM, Lin L: [Improvement of the the thermostability of Penicillium expansum lipase by mutagenesis the random mutant ep8 at K55R]. Sheng Wu Gong Cheng Xue Bao; 2007 Jul;23(4):677-80
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  • In order to improve the thermostability of the Penicillium expansum Lipase (PEL), the lipase encoding genes was mutated by site-directed mutagenesis.
  • A recombinant vector pAO815-ep8-K55R which contain double mutant genes was constructed by overlap extension PCR using the cDNA of a random-mutant lipase ep8 (a single site mutant) as the template and two special primers were used to generate another mutation site K55R.
  • The recombinant vector was transformed into Pichia pastoris GS115 by electroporation and the recombinant mutant GS-pAO815-ep8- K55R can secret double-mutant lipase PEL-ep8-K55R-GS into the medium when it was induced by Methanol.
  • The yield of the double-mutant lipase is 508 u/mL, which is 81% that of the wild type lipase PEL-GS (627 u/mL) and 55% that of random-mutant PEL-ep8-GS (924 u/mL).
  • The specific activity of double-mutant lipase is 2309.1 u/mg, which is similar to random-mutant lipase PEL-ep8-GS and the wild type lipase PEL-GS.
  • The optimum temperature of the double-mutant lipase is same with the wild type lipase PEL-GS and random-mutant lipase PEL-ep8-GS.
  • While the Tm of the double-mutant lipase is 41.0 degrees C, 2.3 degrees C higher than the wild type lipase PEL-GS and 0.8% higher than the random-mutant lipase PEL-ep8-GS, indicating that the double-mutant lipase PEL-ep8-K55R-GS has higher thermostability.

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  • (PMID = 17822043.001).
  • [ISSN] 1000-3061
  • [Journal-full-title] Sheng wu gong cheng xue bao = Chinese journal of biotechnology
  • [ISO-abbreviation] Sheng Wu Gong Cheng Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Mutant Proteins; 0 / Recombinant Proteins; EC 3.1.1.3 / Lipase
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48. Petre CE, Sin SH, Dittmer DP: Functional p53 signaling in Kaposi's sarcoma-associated herpesvirus lymphomas: implications for therapy. J Virol; 2007 Feb;81(4):1912-22
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  • The Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8) is associated with Kaposi's sarcoma (KS) as well as primary effusion lymphomas (PEL).
  • However, DNA-damaging drugs such as doxorubicin are clinically efficacious against PEL and KS, suggesting that p53 signaling remains intact despite the presence of KSHV.
  • To investigate the functionality of p53 in PEL, we examined the response of a large number of PEL cell lines to doxorubicin.
  • Two out of seven (29%) PEL cell lines harbored a mutant p53 allele (BCBL-1 and BCP-1) which led to doxorubicin resistance.
  • In contrast, all other PEL containing wild-type p53 showed DNA damage-induced cell cycle arrest, p53 phosphorylation, and p53 target gene activation.
  • Supporting this finding, chemical inhibition of p53 signaling in PEL led to doxorubicin resistance, and chemical activation of p53 by the Hdm2 antagonist Nutlin-3 led to unimpaired induction of p53 target genes as well as growth inhibition and apoptosis.

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  • (PMID = 17121789.001).
  • [ISSN] 0022-538X
  • [Journal-full-title] Journal of virology
  • [ISO-abbreviation] J. Virol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA109232-05; United States / NCI NIH HHS / CA / CA109232-03S1; United States / NCI NIH HHS / CA / R01 CA109232; United States / NCI NIH HHS / CA / R01 CA163217; United States / NCI NIH HHS / CA / R01 CA109232-04; United States / NCI NIH HHS / CA / CA109232-03; United States / NCI NIH HHS / CA / T32 CA009156; United States / NCI NIH HHS / CA / CA009156; United States / NCI NIH HHS / CA / CA700580; United States / NCI NIH HHS / CA / CA109232-01; United States / NIDCR NIH HHS / DE / R01 DE018304; United States / NCI NIH HHS / CA / CA109232-02; United States / NCI NIH HHS / CA / R01 CA109232-05; United States / NCI NIH HHS / CA / R01 CA109232-02; United States / NCI NIH HHS / CA / CA109232; United States / NCI NIH HHS / CA / R01 CA109232-01; United States / NCI NIH HHS / CA / R01 CA109232-03S1; United States / NCI NIH HHS / CA / R01 CA109232-03; United States / NCI NIH HHS / CA / CA109232-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / Imidazoles; 0 / Piperazines; 0 / Tumor Suppressor Protein p53; 0 / nutlin 3; 80168379AG / Doxorubicin; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
  • [Other-IDs] NLM/ PMC1797584
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49. Muñoz-Fontela C, Marcos-Villar L, Hernandez F, Gallego P, Rodriguez E, Arroyo J, Gao SJ, Avila J, Rivas C: Induction of paclitaxel resistance by the Kaposi's sarcoma-associated herpesvirus latent protein LANA2. J Virol; 2008 Feb;82(3):1518-25
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  • Kaposi's sarcoma-associated herpesvirus (KSHV) is the causal agent of both KS and primary effusion lymphoma (PEL).
  • Although treatment with paclitaxel has significant antitumor activity in KS, drug resistance represents a major obstacle for improving the overall response and survival of PEL patients.
  • This paper focuses on the mechanism of paclitaxel resistance observed in PEL cells.
  • This is the first demonstration of paclitaxel resistance induced by a viral protein and suggests a link between the expression of LANA2 and the resistance of PEL cells to paclitaxel.

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  • (PMID = 18032494.001).
  • [ISSN] 1098-5514
  • [Journal-full-title] Journal of virology
  • [ISO-abbreviation] J. Virol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Viral Proteins; P88XT4IS4D / Paclitaxel
  • [Other-IDs] NLM/ PMC2224414
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50. Wu W, Rochford R, Toomey L, Harrington W Jr, Feuer G: Inhibition of HHV-8/KSHV infected primary effusion lymphomas in NOD/SCID mice by azidothymidine and interferon-alpha. Leuk Res; 2005 May;29(5):545-55
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  • Kaposi's sarcoma-associated herpesvirus/human herpesvirus type-8 (KSHV/HHV-8) is associated with primary effusion lymphomas (PEL), a rare form of B-cell lymphoma.
  • PEL cell lines infected with HHV-8, but negative for Epstein-Barr virus (EBV), were analyzed for their tumorigenic potential in a small animal model system.
  • Inoculation of PEL cell lines into non-obese diabetic/severe combined immunodeficient (NOD/SCID) mice results in efficient engraftment and tumorigenesis in vivo.
  • PEL-engrafted NOD/SCID (PEL/SCID) mice displayed malignant ascites development with notable abdominal distension, consistent with the clinical manifestations of PEL in humans.
  • Azidothymidine (AZT, zidovudine) and interferon-alpha (IFN-alpha) induce apoptosis in HHV-8+/EBV- PEL cells in culture, by induction of a tumor necrosis factor-related apoptosis inducing ligand (TRAIL) mediated suicide program and has been proposed as a therapy for herpesvirus-associated lymphomas.
  • Daily injection of AZT and IFN-alpha significantly increased mean survival time (MST) of PEL/SCID mice suggesting that induction of apoptosis in PEL cells in vivo may be exploited as an effective relatively non-toxic therapy targeting HHV-8 infected PEL.
  • These data demonstrate that the PEL/SCID mouse is an important preclinical model to characterize efficacy and anti-tumor mechanisms of new therapeutic targets in vivo and will be useful in the design and testing of agents in viral lymphoproliferative diseases.

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  • (PMID = 15755507.001).
  • [ISSN] 0145-2126
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Apoptosis Regulatory Proteins; 0 / Interferon-alpha; 0 / Membrane Glycoproteins; 0 / Reverse Transcriptase Inhibitors; 0 / TNF-Related Apoptosis-Inducing Ligand; 0 / TNFSF10 protein, human; 0 / Tnfsf10 protein, mouse; 0 / Tumor Necrosis Factor-alpha; 4B9XT59T7S / Zidovudine
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51. Heuer A, Saksaengwijit A: Properties of ideal Gaussian glass-forming systems. Phys Rev E Stat Nonlin Soft Matter Phys; 2008 Jun;77(6 Pt 1):061507
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  • We introduce the ideal Gaussian glass-forming system as a model to describe the thermodynamics and dynamics of supercooled liquids on a local scale in terms of the properties of the potential energy landscape (PEL).
  • In this way it becomes possible to identify a relevant PEL parameter determining the kinetic fragility.

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  • (PMID = 18643272.001).
  • [ISSN] 1539-3755
  • [Journal-full-title] Physical review. E, Statistical, nonlinear, and soft matter physics
  • [ISO-abbreviation] Phys Rev E Stat Nonlin Soft Matter Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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52. Carbone A, Gloghini A: HHV-8-associated lymphoma: state-of-the-art review. Acta Haematol; 2007;117(3):129-31
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  • During the first decade after the discovery of primary effusion lymphoma (PEL), sporadic and serial reports suggested that Kaposi-sarcoma-associated-herpesvirus/human-herpesvirus-8 (KSHV/HHV-8)-associated lymphomas in their liquid and solid presentation are clinically distinct, representing part of the spectrum of PEL.
  • In HIV-seropositive patients with serous effusions, these solid lymphomas were reported before the development of an effusion lymphoma and following resolution of PEL.

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  • [Copyright] 2007 S. Karger AG, Basel
  • (PMID = 17135725.001).
  • [ISSN] 1421-9662
  • [Journal-full-title] Acta haematologica
  • [ISO-abbreviation] Acta Haematol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 27
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53. Inoue S, Miyamoto T, Yoshino T, Yamadori I, Hagari Y, Yamamoto O: Primary effusion lymphoma with skin involvement. J Clin Pathol; 2006 Nov;59(11):1221-2
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  • Primary effusion lymphoma (PEL) was once defined as a body cavity-based lymphoma without identifiable contiguous tumour mass, but is now recognised as an independent clinicopathological entity.
  • The case of a 67-year-old Japanese woman with PEL is reported, in which the clinical findings showed a pericardial effusion and multiple erythema on the hypogastrium and inguinal region.
  • No tumour mass was observed during the course of her disease.

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  • (PMID = 17071811.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1860519
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54. Youngster I, Vaisben E, Cohen H, Nassar F: An unusual cause of pleural effusion. Age Ageing; 2006 Jan;35(1):94-6
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  • Primary effusion lymphoma (PEL) is a unique clinicopathological entity associated with human herpesvirus-8 (HHV-8) infection, occurring almost exclusively in human immunodeficiency virus (HIV)-infected individuals.
  • We report a rare case of HHV-8-negative PEL in an HIV-negative elderly patient who presented with pleural effusion.
  • As opposed to the general poor outcome of this disease, our patient achieved complete remission and is still without signs of disease 11 months after the last treatment.
  • [MeSH-major] Lymphoma, AIDS-Related / complications. Pleural Effusion, Malignant / etiology
  • [MeSH-minor] Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cyclophosphamide / therapeutic use. Diagnosis, Differential. Doxorubicin / therapeutic use. Follow-Up Studies. HIV. Humans. Male. Prednisone / therapeutic use. Vincristine / therapeutic use

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  • (PMID = 16364944.001).
  • [ISSN] 0002-0729
  • [Journal-full-title] Age and ageing
  • [ISO-abbreviation] Age Ageing
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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55. Stewart CJ, Brennan BA, Crook ML, Russell P: Value of elastin staining in the assessment of peritoneal implants associated with ovarian serous borderline tumours. Histopathology; 2007 Sep;51(3):313-21
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  • [Title] Value of elastin staining in the assessment of peritoneal implants associated with ovarian serous borderline tumours.
  • AIMS: To determine whether elastin stains aid in classifying peritoneal implants associated with ovarian serous borderline tumours (SBT).
  • Elastin stains were performed using histochemical and immunohistochemical methods to demonstrate the peritoneal elastic lamina (PEL), and evaluated with regard to assessment of the subtype of implant.
  • The elastin stains demonstrated the PEL in most anatomical sites other than the omentum and the bladder and were considered helpful in 44/80 (55%) cases.
  • The staining was non-contributory in most of the remaining biopsies, because the PEL was not identified.
  • CONCLUSIONS: Demonstration of the PEL using elastin stains can be useful in the subclassification of implants associated with ovarian SBT and is of most value in confirming the superficial distribution of non-invasive lesions.
  • However, evaluation is limited by the absence of a defined elastic layer in a proportion of biopsy specimens, possibly reflecting their superficial location, as well as absence of a distinct PEL in sites such as the omentum.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Immunohistochemistry. Middle Aged. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / metabolism. Peritoneal Neoplasms / secondary. Predictive Value of Tests

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  • (PMID = 17727474.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 9007-58-3 / Elastin
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56. Heuer A: Exploring the potential energy landscape of glass-forming systems: from inherent structures via metabasins to macroscopic transport. J Phys Condens Matter; 2008 Sep 17;20(37):373101
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  • In this review a systematic analysis of the potential energy landscape (PEL) of glass-forming systems is presented.
  • The relevant energy scales of the PEL can be characterized.
  • The relation to the geometric properties of the PEL is stressed.
  • The emergence of length scales within the PEL approach as well as the nature of finite-size effects is discussed.
  • Furthermore, the PEL view is compared to other approaches describing the glass transition.

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  • (PMID = 21694408.001).
  • [ISSN] 0953-8984
  • [Journal-full-title] Journal of physics. Condensed matter : an Institute of Physics journal
  • [ISO-abbreviation] J Phys Condens Matter
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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57. Towata T, Komizu Y, Suzu S, Ueoka R, Okada S: Highly selective fusion and accumulation of hybrid liposomes into primary effusion lymphoma cells along with induction of apoptosis. Biochem Biophys Res Commun; 2010 Mar 12;393(3):445-8
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  • Primary effusion lymphoma (PEL) is an aggressive neoplasm caused by human herpes virus-8 infection, and is generally resistant to chemotherapy.
  • Hybrid liposomes, composed of dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene (21) dodecyl ether (C12(EO)21) (HL-21), were rapidly accumulated in the membrane of PEL cells.
  • HL-21 also increased membrane fluidity of PEL cells, and induced caspase-3 activation along with cell death.
  • These results suggest that HL-21 should be an effective and attractive regent for PEL treatment.

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  • [Copyright] 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20138834.001).
  • [ISSN] 1090-2104
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Liposomes; 0AWH8BFG9A / polidocanol; 30IQX730WE / Polyethylene Glycols; U86ZGC74V5 / Dimyristoylphosphatidylcholine
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58. Tinari A, Superti F, Ammendolia MG, Chiozzini C, Hohenadl C, Leone P, Nappi F, Nicoletti M, Borsetti A, Marchetti M, Ensoli B, Monini P: Primary effusion lymphoma cells undergoing human herpesvirus type 8 productive infection produce C-type retroviral particles. Int J Immunopathol Pharmacol; 2008 Oct-Dec;21(4):999-1006
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  • [Title] Primary effusion lymphoma cells undergoing human herpesvirus type 8 productive infection produce C-type retroviral particles.
  • Primary effusion lymphomas (PELs) are invariably infected by the human herpesvirus 8 (HHV8)that is present in most PEL cells as latent virus but replicates in a subset of permissive cells to produce infectious progeny.
  • Here we show that productively infected PEL cells release C-type retrovirus-like particles encoding an Mn++-dependent RT activity, which is typical of endogenous retroviruses.
  • Strikingly, C-type particles are produced only in cells showing advanced HHV8 morphogenesis.
  • Phorbol esters, which induce productive HHV8 replication and morphogenesis in PEL cells, increase RLP production.
  • Phosphonoacetic acid, a blocker of HHV8 late gene expression, inhibits the production of C-type particles, whereas neutralizing anti-alphaIFN antibodies, which are known to increase HHV8 assembly, increases C-type particle production.
  • These data suggest that factors expressed in advanced stages of HHV8 reactivation support endogenous C-type particle morphogenesis in PEL cells.

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  • (PMID = 19144286.001).
  • [ISSN] 0394-6320
  • [Journal-full-title] International journal of immunopathology and pharmacology
  • [ISO-abbreviation] Int J Immunopathol Pharmacol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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59. Matta H, Chaudhary PM: The proteasome inhibitor bortezomib (PS-341) inhibits growth and induces apoptosis in primary effusion lymphoma cells. Cancer Biol Ther; 2005 Jan;4(1):77-82
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  • Here we show that Bortezomib (PS-341), a proteasome-inhibitor, inhibits cellular proliferation and induces apoptosis in cell lines derived from Primary Effusion Lymphoma (PEL), a subtype of non-Hodgkin's lymphoma associated with infection by human herpes virus 8 (HHV-8).
  • Bortezomib demonstrated more cytotoxicity against PEL cells than against cell lines derived from multiple myeloma, a disease for which is in current clinical use.
  • Finally, treatment of PEL cells with Bortezomib exerted a synergistic or additive cytotoxic effect in combination with chemotherapeutic drugs or TRAIL.
  • Taken together, these findings suggest that Bortezomib represents a promising agent for the treatment of PEL.

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  • [CommentIn] Cancer Biol Ther. 2005 Apr;4(4):491-2 [15908793.001]
  • (PMID = 15662128.001).
  • [ISSN] 1538-4047
  • [Journal-full-title] Cancer biology & therapy
  • [ISO-abbreviation] Cancer Biol. Ther.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA85177
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Boronic Acids; 0 / Pyrazines; 69G8BD63PP / Bortezomib
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60. Mazzella FM, Smith D, Horn P, Cotelingam JD, Rector JT, Shrit MA, Pesce A, Schumacher HR: Prognostic significance of pronormoblasts in erythrocyte predominant myelodysplastic patients. Am J Hematol; 2006 Jul;81(7):484-91
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  • Recent studies of acute erythroleukemias have reaffirmed DiGuglielmo's syndrome (M6a, myeloblast-predominant) and disease (M6b, pronormoblast-predominant).
  • A 20-year retrospective study was performed to identify cases demonstrating >or=50% erythrocytic component and <30% calculated blasts (FAB exclusion criteria) without underlying cause (96 cases).
  • [MeSH-major] Erythroblasts. Leukemia, Erythroblastic, Acute / pathology. Models, Statistical. Myelodysplastic Syndromes / pathology
  • [MeSH-minor] Age Factors. Disease-Free Survival. Erythrocyte Count. Erythrocytes / pathology. Granulocyte Precursor Cells / pathology. Humans. Male. Middle Aged. Multivariate Analysis. Platelet Count. Predictive Value of Tests. Prognosis. Retrospective Studies


61. Cirone M, Lucania G, Aleandri S, Borgia G, Trivedi P, Cuomo L, Frati L, Faggioni A: Suppression of dendritic cell differentiation through cytokines released by Primary Effusion Lymphoma cells. Immunol Lett; 2008 Oct 30;120(1-2):37-41
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  • Primary effusion lymphoma (PEL) is a Human Herpesvirus-8 (HHV-8)-associated tumor, which releases several cytokines such as IL-6, IL-10 and VEGF and its growth seems to be dependent on them in vitro or in vivo.
  • The iDC obtained in the presence of PEL supernatants showed reduction of FITC-dextran uptake, reduction of MLR allostimulatory activity and altered expression of surface molecules, suggesting that cytokines released by PEL adversely affect DC differentiation.

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  • (PMID = 18680763.001).
  • [ISSN] 0165-2478
  • [Journal-full-title] Immunology letters
  • [ISO-abbreviation] Immunol. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Culture Media, Conditioned; 0 / Cytokines
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62. Deloose ST, Smit LA, Pals FT, Kersten MJ, van Noesel CJ, Pals ST: High incidence of Kaposi sarcoma-associated herpesvirus infection in HIV-related solid immunoblastic/plasmablastic diffuse large B-cell lymphoma. Leukemia; 2005 May;19(5):851-5
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  • Kaposi sarcoma-associated herpesvirus (KSHV) is known to be associated with two distinct lymphoproliferative disorders: primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD)/MCD-associated plasmablastic lymphoma.
  • Our results indicate that KSHV infection is not restricted to PEL and MCD; it is also common (38%) in HIV-related solid immunoblastic/plasmablastic lymphomas.


63. Fujiwara T, Ichinohasama R, Miura I, Sugawara T, Harigae H, Yokoyama H, Takahashi S, Tomiya Y, Yamada M, Ishizawa K, Kameoka J, Sasaki T: Primary effusion lymphoma of the pericardial cavity carrying t(1;22)(q21;q11) and t(14;17)(q32;q23). Cancer Genet Cytogenet; 2005 Jan 1;156(1):49-53
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  • We report a case of primary effusion lymphoma (PEL) in a 75-year-old woman without human immunodeficiency virus or hepatitis C virus, which presented as fever, chest pain, and pericardial effusion.
  • We did not detect C-MYC gene rearrangement or BCL-2 expression.
  • The present case demonstrated a rare category of PEL that is not associated with HHV-8 or C-MYC gene rearrangement.
  • [MeSH-major] Lymphoma, B-Cell / genetics. Pleural Effusion, Malignant / genetics. Translocation, Genetic

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  • (PMID = 15588855.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Hasegawa H, Chatterjee A, Cui Y, Chatterjee AK: Elevated temperature enhances virulence of Erwinia carotovora subsp. carotovora strain EC153 to plants and stimulates production of the quorum sensing signal, N-acyl homoserine lactone, and extracellular proteins. Appl Environ Microbiol; 2005 Aug;71(8):4655-63
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  • Erwinia carotovora subsp. atroseptica, E. carotovora subsp. betavasculorum, and E. carotovora subsp. carotovora produce high levels of extracellular enzymes, such as pectate lyase (Pel), polygalacturonase (Peh), cellulase (Cel), and protease (Prt), and the quorum-sensing signal N-acyl-homoserine lactone (AHL) at 28 degrees C.
  • At elevated temperatures these bacteria produce high levels of RsmA, an RNA binding protein that promotes RNA decay. E. carotovora subsp. carotovora strain EC153 is an exception in that it produces higher levels of Pel, Peh, Cel, and Prt at 34.5 degrees C than at 28 degrees C.
  • EC153 also causes extensive maceration of celery petioles and Chinese cabbage leaves at 34.5 degrees C, which correlates with a higher growth rate and higher levels of rRNA and AHL.
  • The lack of pectinase production by E. carotovora subsp. carotovora strain Ecc71 at 34.5 degrees C limits the growth of this organism in plant tissues and consequently impairs its ability to cause tissue maceration.
  • Comparative studies with ahlI (the gene encoding a putative AHL synthase), pel-1, and peh-1 transcripts documented that at 34.5 degrees C the RNAs are more stable in EC153 than in Ecc71.
  • Our data reveal that overall metabolic activity, AHL levels, and mRNA stability are responsible for the higher levels of extracellular protein production and the enhanced virulence of EC153 at 34.5 degrees C compared to 28 degrees C.
  • [MeSH-major] 4-Butyrolactone / analogs & derivatives. Gene Expression Regulation, Bacterial. Pectobacterium carotovorum / enzymology. Pectobacterium carotovorum / pathogenicity. Temperature

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  • (PMID = 16085860.001).
  • [ISSN] 0099-2240
  • [Journal-full-title] Applied and environmental microbiology
  • [ISO-abbreviation] Appl. Environ. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / RNA-Binding Proteins; 0 / Repressor Proteins; 0 / RsmA protein, Erwinia carotovora; 1192-20-7 / homoserine lactone; OL659KIY4X / 4-Butyrolactone
  • [Other-IDs] NLM/ PMC1183306
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65. Ikebe T, Amemiya Y, Saburi M, Ando T, Kohno K, Ogata M, Hiramatsu K, Kadota J: Rare primary effusion lymphoma associated with HHV-8 in Japan. Intern Med; 2010;49(13):1303-6
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  • We describe a 62-year-old man infected with human immunodeficiency virus (HIV)-1 who developed primary effusion lymphoma (PEL).
  • The patient was administered with highly active anti retroviral therapy (HAART) and THP-COP therapy, resulting in complete remission.
  • Although PEL is extremely rare in Japan, the incidence might increase in the future.
  • [MeSH-major] HIV Infections / complications. Herpesviridae Infections / complications. Herpesvirus 8, Human. Lymphoma, Primary Effusion / diagnosis. Lymphoma, Primary Effusion / virology

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  • (PMID = 20606364.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; VEP-THP protocol
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66. Lim SH, Feng L, Kemling JW, Musto CJ, Suslick KS: An optoelectronic nose for the detection of toxic gases. Nat Chem; 2009 Oct;1(7):562-7
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  • The sensor consists of a disposable array of cross-responsive nanoporous pigments with colours that are changed by diverse chemical interactions with analytes.
  • Clear differentiation among 19 different toxic industrial chemicals (TICs) within two minutes of exposure at concentrations immediately dangerous to life or health were demonstrated.
  • Based on the colour change of the array, quantification of each analyte was accomplished easily, and excellent detection limits were achieved, generally below the permissible exposure limits.

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  • (PMID = 20160982.001).
  • [ISSN] 1755-4349
  • [Journal-full-title] Nature chemistry
  • [ISO-abbreviation] Nat Chem
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / ES016011-03; United States / NIEHS NIH HHS / ES / U01 ES016011; United States / NIEHS NIH HHS / ES / U01 ES016011-03; United States / NIEHS NIH HHS / ES / U01ES016011
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  • [Chemical-registry-number] 0 / Gases
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67. Wilson SJ, Tsao EH, Webb BL, Ye H, Dalton-Griffin L, Tsantoulas C, Gale CV, Du MQ, Whitehouse A, Kellam P: X box binding protein XBP-1s transactivates the Kaposi's sarcoma-associated herpesvirus (KSHV) ORF50 promoter, linking plasma cell differentiation to KSHV reactivation from latency. J Virol; 2007 Dec;81(24):13578-86
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  • Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with the B-cell neoplasm primary effusion lymphoma (PEL), in which the virus remains latent.
  • We have previously shown that PEL cells have the gene expression profile and immunophenotype of cycling preplasma cells (plasmablasts).
  • XBP-1s is normally absent in PEL, but the induction of endoplasmic reticulum stress leads to XBP-1s generation, plasma cell-like differentiation, and lytic reactivation of KSHV.
  • XBP-1s binds to and activates the KSHV immediate-early gene ORF50 and synergizes with the ORF50 gene product RTA to induce a full lytic cycle.

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  • (PMID = 17928342.001).
  • [ISSN] 1098-5514
  • [Journal-full-title] Journal of virology
  • [ISO-abbreviation] J. Virol.
  • [Language] ENG
  • [Databank-accession-numbers] GEO/ GSE9096
  • [Grant] United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Immediate-Early Proteins; 0 / Nuclear Proteins; 0 / Rta protein, Human herpesvirus 8; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Viral Proteins; 0 / regulatory factor X transcription factors
  • [Other-IDs] NLM/ PMC2168861
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68. Wang H, Guo Y, Lv F, Zhu H, Wu S, Jiang Y, Li F, Zhou B, Guo W, Zhang T: The essential role of GhPEL gene, encoding a pectate lyase, in cell wall loosening by depolymerization of the de-esterified pectin during fiber elongation in cotton. Plant Mol Biol; 2010 Mar;72(4-5):397-406
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  • [Title] The essential role of GhPEL gene, encoding a pectate lyase, in cell wall loosening by depolymerization of the de-esterified pectin during fiber elongation in cotton.
  • In this present research, a fiber preferential cDNA encoding a pectate lyase (PEL) which could exclusively degrade the de-esterified pectin was isolated from a cotton (Gossypium hirsutum) fiber cDNA library.
  • Subsequently, the corresponding PEL genes were isolated from four different cotton species and characterized.
  • In vitro enzyme assays indicated that GhPEL really exhibited cleavage-activity against de-esterified pectin.
  • The temporal-spatial expression analyses revealed that the GhPEL gene was preferentially expressed in fibers at 10 days-post anthesis (DPA).
  • Six homozygous lines, each with one or two copies of the transgene inserted as determined by southern blot analysis of the NPTII gene, were selected for further functional analysis.
  • Furthermore, the reduction of GhPEL enzymatic activity by decreasing GhPEL transcripts severely affected the degradation of de-esterified pectin in primary cell walls of transgenic cotton fibers, which consequently blocked cell wall loosening in early fiber development.
  • [MeSH-major] Genes, Plant. Gossypium / enzymology. Gossypium / genetics. Polysaccharide-Lyases / genetics. Polysaccharide-Lyases / metabolism
  • [MeSH-minor] Amino Acid Sequence. Base Sequence. Cell Wall / metabolism. Cotton Fiber. DNA, Complementary / genetics. DNA, Plant / genetics. Gene Expression Regulation, Developmental. Gene Expression Regulation, Plant. Molecular Sequence Data. Pectins / metabolism. Phylogeny. Plants, Genetically Modified. Recombinant Proteins / genetics. Recombinant Proteins / metabolism. Sequence Homology, Amino Acid. Species Specificity

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  • (PMID = 20131110.001).
  • [ISSN] 1573-5028
  • [Journal-full-title] Plant molecular biology
  • [ISO-abbreviation] Plant Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / DNA, Plant; 0 / Pectins; 0 / Recombinant Proteins; 9000-69-5 / pectin; EC 4.2.2.- / Polysaccharide-Lyases; EC 4.2.2.2 / pectate lyase
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69. Lory S, Merighi M, Hyodo M: Multiple activities of c-di-GMP in Pseudomonas aeruginosa. Nucleic Acids Symp Ser (Oxf); 2009;(53):51-2
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  • [Title] Multiple activities of c-di-GMP in Pseudomonas aeruginosa.
  • Formation of various biofilm components, including the synthesis of the extracellular polysaccharide matrix, is controlled at the transcriptional and translational levels and also by a small molecule second messenger bis-(3',5')-cyclic-di-guanidine monophosphate (c-di-GMP).
  • The synthesis of c-di-GMP from GTP and its degradation is controlled by diguanylate cyclases (DGCs) and phosphodiesterases (PDEs), encoded by over thirty genes in the P. aeruginosa genome.
  • We have shown that an increase in the intracellular c-di-GMP levels favors biofilm formation due to its role as a cofactor for the synthesis of several types of extracellular polysaccharides, including PEL and alginate, the two key virulence factors of P. aeruginosa during infection of patients with cystic fibrosis.
  • During biosynthesis of PEL and alginate, c-di-GMP binds to specific receptors, PelD and Alg44, respectively.
  • These atypical cyclic dinucleotides bind c-di-GMP receptors with high affinity, suggesting that intracellular regulation of various biological functions by this group of second messengers may be more complex than previously recognized.

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  • (PMID = 19749255.001).
  • [ISSN] 1746-8272
  • [Journal-full-title] Nucleic acids symposium series (2004)
  • [ISO-abbreviation] Nucleic Acids Symp Ser (Oxf)
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI021451
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Alg44 protein, Pseudomonas aeruginosa; 0 / Alginates; 0 / Bacterial Proteins; 0 / Hexuronic Acids; 0 / Membrane Proteins; 0 / Polysaccharides, Bacterial; 61093-23-0 / bis(3',5')-cyclic diguanylic acid; 8A5D83Q4RW / Glucuronic Acid; 8C3Z4148WZ / alginic acid; H2D2X058MU / Cyclic GMP
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70. Doctor PB, Bhagia LJ, Derasari AY, Vyas JB, Amin RJ, Ghosh SK: A preliminary study on gram-negative bacteria (GNB) and their endotoxins in a gin house in India. J Occup Environ Hyg; 2006 Dec;3(12):707-12
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  • The presence of byssinosis, an occupational disease found among cotton mill workers, has been well documented in different parts of the world.
  • The disease develops due to exposure to environmental cotton dust.
  • Evidence suggests that the causative agent for the disease is gram-negative bacteria (GNB) and their endotoxins present on the cotton fibers.
  • Airborne dust concentrations were very high in the working environment: 2.11 mg/m3 in ginning and 0.95 mg/m3 in the press department (p < 0.05), which was higher than the threshold limit value collected by VE (0.2 mg/m3), and higher than the permissible exposure limit for respirable dust (0.5 mg/m3 for nontextile industries using cotton).
  • The Occupational Safety and Health Administration's cotton dust standard permissible exposure limit for respirable dust is 0.2 mg/m3 in yarn manufacturing, 0.75 mg/m3 in slashing and weaving, and 0.5 mg/m3 in nontextile industries using cotton.
  • Total enumeration of airborne GNB was carried out qualitatively by the petri plate exposure method and quantitatively by an Andersen 6-stage viable sampler and VE.
  • [MeSH-major] Air Pollutants, Occupational / analysis. Endotoxins / analysis. Gram-Negative Bacteria / chemistry. Occupational Exposure. Textile Industry

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  • (PMID = 17133691.001).
  • [ISSN] 1545-9624
  • [Journal-full-title] Journal of occupational and environmental hygiene
  • [ISO-abbreviation] J Occup Environ Hyg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Air Pollutants, Occupational; 0 / Dust; 0 / Endotoxins
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71. Maeder M, Spieler P, Krapf R, Diethelm M: Cytologically malignant lymphoid pericardial effusion with benign clinical outcome. Swiss Med Wkly; 2005 Jun 25;135(25-26):377-81
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  • [Title] Cytologically malignant lymphoid pericardial effusion with benign clinical outcome.
  • BACKGROUND: Isolated malignant pericardial effusion is a manifestation of primary cardiac lymphoma (PCL) and primary effusion lymphoma (PEL), rare types of non-Hodgkin's lymphoma (NHL).
  • The diagnosis is based on different cytological methods and analyses including DNA-image cytometry (ICM-DNA).
  • CONCLUSIONS: Despite the highly atypical cytomorphology including unequivocal DNA aneuploidy, long-term survival in both patients strongly suggests that pronounced reactive lymphocytic changes are probably due to viral pericarditis rather than PCL or PEL as underlying conditions.
  • It seems that DNA-aneuploidy may be not absolutely specific for the detection of malignant lymphoid cells in pericardial fluid.
  • [MeSH-major] Heart Neoplasms / diagnosis. Lymphoma, Non-Hodgkin / diagnosis. Pericardial Effusion / diagnosis

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  • (PMID = 16106328.001).
  • [ISSN] 1424-7860
  • [Journal-full-title] Swiss medical weekly
  • [ISO-abbreviation] Swiss Med Wkly
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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72. Lee JH, Kim HE, Im JH, Bae YM, Choi JS, Huh KM, Lee CS: Preparation of orthogonally functionalized surface using micromolding in capillaries technique for the control of cellular adhesion. Colloids Surf B Biointerfaces; 2008 Jun 15;64(1):126-34
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  • The other region was coated with polyelectrolyte (PEL) to promote the adhesion of biomolecules including proteins and cells.
  • Resistance to the adsorption of proteins increased with the length of PEG and PLA chains because the longer PEG chain increased the PEG layer thickness and the longer PLA chain induced stronger interaction with the PEL surface.
  • The orthogonal functionality of prepared surfaces having PEL regions and background PEG-PLA regions resulted in rapid patterning of biomolecules.
  • Fluorescein isothiocyanate-tagged bovine serum albumin (FITC-BSA) and fibroblast cells successfully adhered to the exposed PEL surfaces.

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  • (PMID = 18304784.001).
  • [ISSN] 0927-7765
  • [Journal-full-title] Colloids and surfaces. B, Biointerfaces
  • [ISO-abbreviation] Colloids Surf B Biointerfaces
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Serum Albumin, Bovine; 0 / fluorescein isothiocyanate bovine serum albumin; 30IQX730WE / Polyethylene Glycols; 9004-74-4 / monomethoxypolyethylene glycol; I223NX31W9 / Fluorescein-5-isothiocyanate
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73. Ryder C, Byrd M, Wozniak DJ: Role of polysaccharides in Pseudomonas aeruginosa biofilm development. Curr Opin Microbiol; 2007 Dec;10(6):644-8
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  • Here, we focus on recent developments regarding the roles of alginate, Psl, and Pel polysaccharides in the biofilm matrix.

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  • (PMID = 17981495.001).
  • [ISSN] 1369-5274
  • [Journal-full-title] Current opinion in microbiology
  • [ISO-abbreviation] Curr. Opin. Microbiol.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / HL058334-09A1; United States / NIAID NIH HHS / AI / R21 AI061396; United States / NIAID NIH HHS / AI / AI061396-03; United States / NIAID NIH HHS / AI / AI061396; United States / NHLBI NIH HHS / HL / R01 HL058334; United States / NHLBI NIH HHS / HL / R01 HL058334-08; United States / NIAID NIH HHS / AI / R56 AI061396; United States / NIAID NIH HHS / AI / R01 AI061396; United States / NHLBI NIH HHS / HL / HL058334-08; United States / NHLBI NIH HHS / HL / R01 HL058334-09A1; United States / NIAID NIH HHS / AI / R01 AI061396-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Alginates; 0 / Bacterial Proteins; 0 / Polysaccharides, Bacterial; 128531-82-8 / exopolysaccharide, Pseudomonas
  • [Number-of-references] 36
  • [Other-IDs] NLM/ NIHMS35932; NLM/ PMC2176169
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74. Zhang YJ, Wang KY, Stein DA, Patel D, Watkins R, Moulton HM, Iversen PL, Matson DO: Inhibition of replication and transcription activator and latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus by morpholino oligomers. Antiviral Res; 2007 Jan;73(1):12-23
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  • Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with Kaposi's sarcoma and primary effusion lymphoma (PEL).
  • In this study, RTA and LANA mRNA in PEL cells were targeted by antisense peptide-conjugated PMO (P-PMO) in an effort to suppress KSHV replication.
  • Highly efficient P-PMO uptake by PEL cells was observed.
  • Treatment of PEL cells with a RTA P-PMO (RP1) reduced RTA expression in a dose-dependent and sequence-specific manner, and also caused a significant decrease in several KSHV early and late gene products, including vIL-6, vIRF-1, and ORF-K8.1A.
  • KSHV viral DNA levels were reduced both in cells and culture supernatants of RP1 P-PMO-treated cells, indicating that KSHV lytic replication was suppressed.

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  • (PMID = 16842866.001).
  • [ISSN] 0166-3542
  • [Journal-full-title] Antiviral research
  • [ISO-abbreviation] Antiviral Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA103612-02; United States / NCI NIH HHS / CA / R21 CA103612-02; United States / NCI NIH HHS / CA / R21 CA103612-01A2; United States / NCI NIH HHS / CA / CA103612-03; United States / NCI NIH HHS / CA / CA103612-01A2; United States / NCI NIH HHS / CA / CA-103612; United States / NCI NIH HHS / CA / R21 CA103612; United States / NCI NIH HHS / CA / R21 CA103612-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, Viral; 0 / Immediate-Early Proteins; 0 / Morpholines; 0 / Morpholinos; 0 / Nuclear Proteins; 0 / Rta protein, Human herpesvirus 8; 0 / Trans-Activators; 0 / Viral Proteins; 0 / latency-associated nuclear antigen
  • [Other-IDs] NLM/ NIHMS44954; NLM/ PMC2390898
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75. Nakashima T, Kaneko K, Goto Y, Abe T, Mitsudo T, Ogata K, Makinouchi A, Tobimatsu S: Early ERP components differentially extract facial features: evidence for spatial frequency-and-contrast detectors. Neurosci Res; 2008 Dec;62(4):225-35
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  • Next, we created physically equiluminant (PEL) face stimuli to eliminate the effects of lower order information, such as luminance and contrast.
  • The occipital P1 amplitude for PEL faces was relatively unaffected compared with that for PEL houses.
  • In addition, the occipital N2 for PEL faces was spatiotemporally separable from N170 in a time-window between P1 and N170.

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  • (PMID = 18809442.001).
  • [ISSN] 0168-0102
  • [Journal-full-title] Neuroscience research
  • [ISO-abbreviation] Neurosci. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
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76. Towata T, Komizu Y, Suzu S, Matsumoto Y, Ueoka R, Okada S: Hybrid liposomes inhibit the growth of primary effusion lymphoma in vitro and in vivo. Leuk Res; 2010 Jul;34(7):906-11
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  • Primary effusion lymphoma (PEL) is an aggressive neoplasm caused by Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV-8) infection.
  • Hybrid liposomes (HL), composed of dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene dodecyl ether, inhibited PEL cell proliferation and induced apoptosis in vitro.
  • Intraperitoneal inoculation of the BCBL-1 PEL cell line into NOD/Scid/Jak3 deficient mice induced massive ascites, which were inhibited by HL21 without significant systemic toxicity in the mice.
  • These results suggest that HL21 is an effective and attractive reagent for PEL treatment.

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  • [Copyright] Copyright 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 20074798.001).
  • [ISSN] 1873-5835
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Liposomes; 0 / polyoxyethylene-10-dodecyl ether; 30IQX730WE / Polyethylene Glycols; EC 2.7.10.2 / Jak3 protein, mouse; EC 2.7.10.2 / Janus Kinase 3; U86ZGC74V5 / Dimyristoylphosphatidylcholine
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77. Davis DA, Singer KE, Reynolds IP, Haque M, Yarchoan R: Hypoxia enhances the phosphorylation and cytotoxicity of ganciclovir and zidovudine in Kaposi's sarcoma-associated herpesvirus infected cells. Cancer Res; 2007 Jul 15;67(14):7003-10
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  • Primary effusion lymphoma (PEL) is a rare B-cell lymphoma caused by Kaposi's sarcoma-associated herpesvirus (KSHV).
  • PEL is poorly responsive to standard cytotoxic chemotherapy and portends a poor survival.
  • It is known that KSHV encodes two lytic genes, ORF36 (phosphotransferase) and KSHV ORF21 (thymidine kinase), which can phosphorylate ganciclovir and azidothymidine, respectively.
  • Here, we have explored whether these genes can be used as therapeutic targets for PEL.
  • PEL arises in pleural spaces and other effusions that provide a hypoxic environment.
  • Based on Northern blot analysis, exposure of PEL cells to hypoxia up-regulated the expression of both ORF36 and ORF21.
  • Using a newly developed nonradioactive reverse-phase high-performance liquid chromatography/mass spectrometry method to separate and quantify the phosphorylated forms of ganciclovir and azidothymidine, we found that PEL cells exposed to hypoxia produced increased amounts of the toxic triphosphates of these drugs.
  • Moreover, we found that hypoxia increased the cell toxicity of ganciclovir and azidothymidine in PEL cells but had no significant effect on the herpesvirus-negative cell line CA46.
  • These findings may have clinical applicability in the development of effective therapies for PEL or other KSHV-related malignancies.

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  • (PMID = 17638913.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antiviral Agents; 4B9XT59T7S / Zidovudine; P9G3CKZ4P5 / Ganciclovir
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78. Ogata N, Shibata T: Protective effect of low-concentration chlorine dioxide gas against influenza A virus infection. J Gen Virol; 2008 Jan;89(Pt 1):60-7
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  • We demonstrate that infection of mice induced by aerosols of influenza A virus was prevented by chlorine dioxide (ClO(2)) gas at an extremely low concentration (below the long-term permissible exposure level to humans, namely 0.1 p.p.m.).
  • Three days after exposure, pulmonary virus titre (TCID(50)) was 10(2.6+/-1.5) in five mice treated with ClO(2), whilst it was 10(6.7+/-0.2) in five mice that had not been treated (P=0.003).
  • Taken together, we conclude that ClO(2) gas is effective at preventing aerosol-induced influenza virus infection in mice by denaturing viral envelope proteins at a concentration well below the permissible exposure level to humans.

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  • (PMID = 18089729.001).
  • [ISSN] 0022-1317
  • [Journal-full-title] The Journal of general virology
  • [ISO-abbreviation] J. Gen. Virol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Aerosols; 0 / Anti-Bacterial Agents; 0 / Chlorine Compounds; 0 / Hemagglutinins, Viral; 0 / Oxides; 8061YMS4RM / chlorine dioxide; EC 3.2.1.18 / Neuraminidase
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79. Mangold C, Clark K, Madl A, Paustenbach D: An exposure study of bystanders and workers during the installation and removal of asbestos gaskets and packing. J Occup Environ Hyg; 2006 Feb;3(2):87-98
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  • [Title] An exposure study of bystanders and workers during the installation and removal of asbestos gaskets and packing.
  • The intent of the studies performed from 1982 through 1991 was to re-create the Navy's work practices in a contaminant-free environment during an 8-hour workday (so the data could be compared with the OSHA permissible exposure limit [PEL]).
  • The results indicate that the 8-hour time-weighted average (TWA) exposures of pipefitters and other tradesmen who performed these activities were below the current PEL and all previous PELs.
  • Likewise, the 8-hour TWA breathing zone concentrations of a worker removing and replacing asbestos valve packing did not exceed 0.016 f/cc.
  • In most cases, the concentrations were not distinguishable from ambient levels of asbestos in the ships or the general environment.
  • [MeSH-major] Air Pollutants / analysis. Asbestos, Serpentine / analysis. Military Personnel. Occupational Exposure

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  • (PMID = 16418082.001).
  • [ISSN] 1545-9624
  • [Journal-full-title] Journal of occupational and environmental hygiene
  • [ISO-abbreviation] J Occup Environ Hyg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Air Pollutants; 0 / Asbestos, Serpentine
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80. Rudra A, Deepa RM, Ghosh MK, Ghosh S, Mukherjee B: Doxorubicin-loaded phosphatidylethanolamine-conjugated nanoliposomes: in vitro characterization and their accumulation in liver, kidneys, and lungs in rats. Int J Nanomedicine; 2010;5:811-23
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  • Doxorubicin-loaded liposomes (DOX-L) and PE-conjugated doxorubicin-loaded liposomes (DOX-PEL) were of smooth surface and homogenously distributed in nanosize range (32-37 nm) with a negative surface charge.
  • Loading efficiencies were 49.25% ± 1.05% and 52.98% ± 3.22% respectively, for DOX-L and DOX-PEL.
  • In vitro drug release study showed 69.91% ± 1.05% and 77.07% ± 1.02% doxorubicin released, from DOX-L and DOX-PEL, respectively, in nine hours.

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  • (PMID = 21042545.001).
  • [ISSN] 1178-2013
  • [Journal-full-title] International journal of nanomedicine
  • [ISO-abbreviation] Int J Nanomedicine
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] New Zealand
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Excipients; 0 / Fluorescent Dyes; 0 / Liposomes; 0 / Nanoconjugates; 0 / Phosphatidylethanolamines; 39382-08-6 / phosphatidylethanolamine; 80168379AG / Doxorubicin; I223NX31W9 / Fluorescein-5-isothiocyanate
  • [Other-IDs] NLM/ PMC2963929
  • [Keywords] NOTNLM ; doxorubicin / phosphatidylethanolamine-conjugated nanoliposomes / tissue accumulation
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81. Zenda T, Tominaga K, Choto S, Okada T, Kaneko S, Minato H: [Diffuse large B-cell lymphoma initially manifested by massive ascites and a small gastric lesion, clinically mimicking primary effusion lymphoma (PEL) in the abdominal cavity: a case report and review of the literature on Japanese PEL patients]. Nihon Shokakibyo Gakkai Zasshi; 2007 Dec;104(12):1772-80
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  • [Title] [Diffuse large B-cell lymphoma initially manifested by massive ascites and a small gastric lesion, clinically mimicking primary effusion lymphoma (PEL) in the abdominal cavity: a case report and review of the literature on Japanese PEL patients].
  • The patient was treated with chemotherapy including rituximab (R-CHOP-ESHAP) and injection of methotrexate and dexamethasone into the medullary cavity as well as radiation to the whole brain, and achieved complete remission 4 months later.
  • [MeSH-major] Lymphoma, Large B-Cell, Diffuse / diagnosis. Lymphoma, Primary Effusion / diagnosis
  • [MeSH-minor] Ascites / complications. Diagnosis, Differential. Humans. Male. Middle Aged. Stomach Neoplasms / pathology


82. Gasperini P, Tosato G: Targeting the mammalian target of Rapamycin to inhibit VEGF and cytokines for the treatment of primary effusion lymphoma. Leukemia; 2009 Oct;23(10):1867-74
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  • Primary effusion lymphoma (PEL) is a fatal malignancy, which typically presents as a lymphomatous effusion that later disseminates.
  • Rapamycin (Rapa), which targets mTOR (mammalian target of Rapa), is currently evaluated as a treatment for PEL, but the recent development of PEL in Rapa-treated post-transplant recipients questions the drug's use in PEL.
  • Here, we used a murine model of PEL effusion that mimics the human disease to investigate the anti-PEL activity of Rapa.
  • Initially, Rapa reduced PEL load compared with control mice, but most mice rapidly showed PEL progression.
  • Levels of VEGF, which promotes vascular permeability contributing to effusion formation, were significantly reduced in ascites of Rapa-treated mice compared with controls.
  • Expression of IL-10, the principal autocrine growth factor for PEL, was initially reduced in PEL from Rapa-treated mice but rapidly increased despite treatment.
  • We found that the hypoxic environment of ascites and Rapa cooperate in stimulating IL-10 expression in PEL, which likely contributes to the emergence of drug resistance.
  • These results identify Rapa an effective drug to reduce PEL effusions but illustrate the rapid development of drug resistance, which likely limits the efficacy of Rapa in PEL.

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  • (PMID = 19554030.001).
  • [ISSN] 1476-5551
  • [Journal-full-title] Leukemia
  • [ISO-abbreviation] Leukemia
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / / NIH0012215497; United States / PHS HHS / / NIH0012215497; United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; 0 / Interleukin-6; 0 / Vascular Endothelial Growth Factors; 130068-27-8 / Interleukin-10; EC 2.7.- / Protein Kinases; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.1.1 / mTOR protein, mouse; W36ZG6FT64 / Sirolimus
  • [Other-IDs] NLM/ NIHMS113595; NLM/ PMC2940422
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83. Salter WB, Kinney K, Wallace WH, Lumley AE, Heimbuch BK, Wander JD: Analysis of residual chemicals on filtering facepiece respirators after decontamination. J Occup Environ Hyg; 2010 Aug;7(8):437-45
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  • Measured amounts of decontaminants retained by the FFRs treated with chemical disinfectants were small enough that exposure to wearers will be below the permissible exposure limit (PEL).

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  • (PMID = 20526947.001).
  • [ISSN] 1545-9632
  • [Journal-full-title] Journal of occupational and environmental hygiene
  • [ISO-abbreviation] J Occup Environ Hyg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Epoxy Compounds; 0 / Oxidants; 74087-85-7 / dimethyldioxirane; BBX060AN9V / Hydrogen Peroxide; DY38VHM5OD / Sodium Hypochlorite
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84. Michibata H, Okuno T, Konishi N, Wakimoto K, Kyono K, Aoki K, Kondo Y, Takata K, Kitamura Y, Taniguchi T: Inhibition of mouse GPM6A expression leads to decreased differentiation of neurons derived from mouse embryonic stem cells. Stem Cells Dev; 2008 Aug;17(4):641-51
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  • Glycoprotein M6A (GPM6A) is known as a transmembrane protein and an abundant cell surface protein on neurons in the central nervous system (CNS).
  • Real-time polymerase chain reaction (real-time PCR) and immunocytochemical analysis showed that expression of shRNA against GPM6A markedly reduced the expression of neuroectodermal-associated genes (OTX1, Lmx1b, En1, Pax2, Pax5, Sox1, Sox2, and Wnt1), and also the number of neural stem cells (NSC) derived from D3mshM6A cells compared to control vector-transfected mouse ES cells (D3m-Mock).
  • Hence, our findings suggest that expression level of GPM6A is directly or indirectly associated with the differentiation of neurons derived from undifferentiated ES cells.
  • [MeSH-major] Antigens, Differentiation / biosynthesis. Cell Differentiation / physiology. Embryonic Stem Cells / metabolism. Gene Expression Regulation / physiology. Membrane Glycoproteins / biosynthesis. Nerve Tissue Proteins / biosynthesis. Neurons / metabolism
  • [MeSH-minor] Animals. COS Cells. Central Nervous System / cytology. Central Nervous System / metabolism. Cercopithecus aethiops. Gene Expression. Mice. Promoter Regions, Genetic / genetics. RNA, Small Nuclear / genetics

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  • (PMID = 18522499.001).
  • [ISSN] 1557-8534
  • [Journal-full-title] Stem cells and development
  • [ISO-abbreviation] Stem Cells Dev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Differentiation; 0 / Gpm6a protein, mouse; 0 / Membrane Glycoproteins; 0 / Nerve Tissue Proteins; 0 / RNA, Small Nuclear; 0 / U6 small nuclear RNA
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85. Lee SH, Choi IA, Lee YA, Park EK, Kim YH, Kim KS, Hong SJ, Yoo MC, Yang HI: Human leukocyte antigen-B*2705 is the predominant subtype in the Korean population with ankylosing spondylitis, unlike in other Asians. Rheumatol Int; 2008 Nov;29(1):43-6
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  • We determined the HLA subtypes of 267 SpA patients who were positive for the B27 antigen (as determined by serology) by using a PEL-FREEZ kit (Dynal Biotech, Wisconsin, USA).
  • We found that HLA-B*2705 was the predominant subtype in Koreans with SpA; this finding is remarkable because other Asians such as the Han or the Japanese exclusively have the B*2704 subtype.
  • [MeSH-minor] Adult. Cross-Sectional Studies. Female. Genetic Predisposition to Disease. Humans. Korea / epidemiology. Male. Young Adult

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  • (PMID = 18493767.001).
  • [ISSN] 0172-8172
  • [Journal-full-title] Rheumatology international
  • [ISO-abbreviation] Rheumatol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / HLA-B27 Antigen
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86. Lv QF, Zhang W, He J, Wang W, Han ZD, Zhu FM, Yan LX: [Sequence analysis of a novel HLA-A*3308 allele]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2006 Jun;23(3):269-71
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  • [Title] [Sequence analysis of a novel HLA-A*3308 allele].
  • METHODS: DNA was extracted from whole blood by PEL-FREEZ DNA extraction kit.

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  • (PMID = 16767661.001).
  • [ISSN] 1003-9406
  • [Journal-full-title] Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
  • [ISO-abbreviation] Zhonghua Yi Xue Yi Chuan Xue Za Zhi
  • [Language] chi
  • [Databank-accession-numbers] GENBANK/ DQ089631/ DQ089632/ DQ089633
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / HLA-A Antigens
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87. Bidwell LA, Bowker RM: Evaluation of changes in architecture of the stratum internum of the hoof wall from fetal, newborn, and yearling horses. Am J Vet Res; 2006 Dec;67(12):1947-55
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  • OBJECTIVE: To evaluate morphologic changes of the stratum internum of hooves from near-term fetal, newborn, and yearling horses.
  • PROCEDURES: Primary epidermal laminae (PEL) of the stratum internum were examined for evidence of architectural changes.
  • RESULTS: In near-term fetuses, the PEL had a homogeneous appearance and symmetric distribution around the hoof wall with no significant differences in PEL density between the toe and quarters.
  • However after birth, branched laminae at the toe formed within the first few weeks, which significantly increased PEL density at the toe, compared with the quarters.
  • In yearlings, morphology of the PEL differed from that in younger foals and the PEL density was significantly greater at the toe than the quarters.
  • The PEL density at the toe and medial and lateral quarters was significantly different from each other, as these PEL densities appeared to have been associated with conformation.
  • No significant differences in PEL densities between forefeet and hind feet were detected in any group.
  • CONCLUSIONS AND CLINICAL RELEVANCE: Findings indicate that the stratum internum of the inner hoof wall undergoes several morphologic changes shortly after birth.
  • The PEL become branched with a greater PEL density at the toe than the quarters.
  • In an asymmetric foot, more PEL were associated with the sloping side than the steep side of the foot.
  • Findings suggested that PEL growth may also occur by bifurcation as well as by mitosis from the coronet and that wall stress may be associated with increased PEL density.

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  • (PMID = 17144792.001).
  • [ISSN] 0002-9645
  • [Journal-full-title] American journal of veterinary research
  • [ISO-abbreviation] Am. J. Vet. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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88. Sirianni MC, Libi F, Campagna M, Rossi D, Capello D, Sciaranghella G, Carbone A, Simonelli C, Monini P, Gaidano G, Ensoli B: Downregulation of the major histocompatibility complex class I molecules by human herpesvirus type 8 and impaired natural killer cell activity in primary effusion lymphoma development. Br J Haematol; 2005 Jul;130(1):92-5
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  • [Title] Downregulation of the major histocompatibility complex class I molecules by human herpesvirus type 8 and impaired natural killer cell activity in primary effusion lymphoma development.
  • Primary effusion lymphomas (PELs) are invariably infected by human herpesvirus type 8 (HHV8) and often co-infected by Epstein-Barr virus (EBV).
  • We found that expression of major histocompatibility complex class I (MHC-I) surface molecules was significantly decreased in PEL cells when compared with HHV8 negative lymphomas, irrespective of EBV infection.
  • MHC-I downregulation rendered PEL cells sensitive to recognition and killing by natural killer (NK) cells.
  • Intriguingly, analysis of MHC-I non-restricted cytotoxicity in two PEL patients indicated a reduced NK cell activity when compared with healthy individuals.
  • These data suggest that PEL outgrowth may require an impaired NK cell function.
  • [MeSH-major] B-Lymphocytes / immunology. Herpesviridae Infections / immunology. Herpesvirus 8, Human. Histocompatibility Antigens Class I / analysis. Killer Cells, Natural / immunology. Lymphoma, B-Cell / immunology. Lymphoma, B-Cell / virology
  • [MeSH-minor] Biomarkers / analysis. Case-Control Studies. Cytotoxicity Tests, Immunologic. DNA, Viral / analysis. Down-Regulation. Epstein-Barr Virus Infections / diagnosis. Epstein-Barr Virus Infections / immunology. Herpesvirus 4, Human / genetics. Humans. Serologic Tests

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  • [ErratumIn] Br J Haematol. 2005 Oct;131(2):282
  • (PMID = 16044583.001).
  • [ISSN] 0007-1048
  • [Journal-full-title] British journal of haematology
  • [ISO-abbreviation] Br. J. Haematol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / DNA, Viral; 0 / Histocompatibility Antigens Class I
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89. Grossmann C, Ganem D: Effects of NFkappaB activation on KSHV latency and lytic reactivation are complex and context-dependent. Virology; 2008 May 25;375(1):94-102
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  • The latent v-FLIP gene is a strong activator of NFkappaB, and in primary effusion lymphoma (PEL) cells, blockade of NFkappaB activation is associated with enhanced lytic gene expression, while overexpression of p65 impairs expression of reporter genes driven by lytic promoters.
  • In accord with earlier work, we find that inhibition of NFkappaB signaling in PEL cells is associated with enhanced lytic reactivation of KSHV.
  • Similarly, in de novo KSHV infection of primary endothelial cells, inhibition of NFkappaB signaling leads to an increase in lytic gene expression and enhanced virion production.
  • Moreover, if NFkappaB activation is always inhibitory to lytic gene expression, one might expect its activation to be suppressed during the lytic cycle.
  • Together these data indicate that (i) the relationship of NFkappaB activation to latency and lytic reactivation is not uniform, but is dependent on the cellular context; and (ii) even though NFkappaB activation is inhibitory to lytic gene expression in some contexts, such inhibition is at least partially bypassed or overridden during lytic growth.

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  • (PMID = 18321555.001).
  • [ISSN] 0042-6822
  • [Journal-full-title] Virology
  • [ISO-abbreviation] Virology
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA073506-10; United States / NCI NIH HHS / CA / R01 CA073506; United States / NCI NIH HHS / CA / R01 CA073506-10
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / NF-kappa B
  • [Other-IDs] NLM/ NIHMS51306; NLM/ PMC2822626
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90. Xu D, Coleman T, Zhang J, Fagot A, Kotalik C, Zhao L, Trivedi P, Jones C, Zhang L: Epstein-Barr virus inhibits Kaposi's sarcoma-associated herpesvirus lytic replication in primary effusion lymphomas. J Virol; 2007 Jun;81(11):6068-78
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  • The majority of AIDS-associated primary effusion lymphomas (PEL) are latently infected with both Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV).
  • We show EBV inhibits chemically induced KSHV lytic replication, in part because of a regulatory loop in which K-RTA induces EBV LMP-1 and LMP-1 in turn inhibits K-RTA expression and furthermore the lytic gene expression of KSHV.
  • Suppression of LMP-1 expression in dually infected PEL cells enhances the expression of K-RTA and lytic replication of KSHV upon chemical induction.
  • Our findings provide evidence that an interaction between EBV and KSHV at molecular levels promotes the maintenance and possibly establishment of viral latency, which may contribute to pathogenesis of PELs.

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  • (PMID = 17376914.001).
  • [ISSN] 0022-538X
  • [Journal-full-title] Journal of virology
  • [ISO-abbreviation] J. Virol.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / T32 AI060547; United States / NCI NIH HHS / CA / R01 CA108951; United States / NIAID NIH HHS / AI / R21AI59132; United States / NIAID NIH HHS / AI / R21 AI059132; United States / NCRR NIH HHS / RR / P20RR15635; United States / NIAID NIH HHS / AI / U54 AI057160; United States / NCRR NIH HHS / RR / P20 RR015635; United States / NCI NIH HHS / CA / R01CA108951
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1900272
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91. Uang SN, Shih TS, Chang CH, Chang SM, Tsai CJ, Deshpande CG: Exposure assessment of organic solvents for aircraft paint stripping and spraying workers. Sci Total Environ; 2006 Mar 1;356(1-3):38-44
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  • [Title] Exposure assessment of organic solvents for aircraft paint stripping and spraying workers.
  • The main objective of this study is to investigate the personal or area exposure of organic solvents during paint stripping and paint spraying.
  • Activated charcoal tubes were used to investigate the personal and area exposure concentration of organic solvents in paint stripping and paint spraying operations.
  • During aircraft paint stripping, experiment results show that methylene chloride personal exposure concentration at the ground area, 42.01+/-31.86 ppm, is higher than that at the working platform 4 M high above the ground, 20.41+/-11.43 ppm.
  • Exposure concentration of methylene chloride in the initial paint stripping operation stage of every workplace is over the PEL (50 ppm) set by the Taiwan Council of Labor Affairs.
  • During paint spraying, concentrations of all organic solvents were found to be below the PEL of OSHA.
  • [MeSH-major] Air Pollutants, Occupational / analysis. Aircraft. Occupational Exposure / analysis. Paint. Solvents / analysis

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  • (PMID = 15885752.001).
  • [ISSN] 0048-9697
  • [Journal-full-title] The Science of the total environment
  • [ISO-abbreviation] Sci. Total Environ.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Air Pollutants, Occupational; 0 / Solvents
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92. Möbius W, Patzig J, Nave KA, Werner HB: Phylogeny of proteolipid proteins: divergence, constraints, and the evolution of novel functions in myelination and neuroprotection. Neuron Glia Biol; 2008 May;4(2):111-27
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  • Three paralog proteolipids (PLP/DM20/DMalpha, M6B/DMgamma and the neuronal glycoprotein M6A/DMbeta) exist in vertebrates from cartilaginous fish to mammals, and one (M6/CG7540) can be traced in invertebrate bilaterians including the planktonic copepod Calanus finmarchicus that possess a functional myelin equivalent.

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  • (PMID = 19497142.001).
  • [ISSN] 1741-0533
  • [Journal-full-title] Neuron glia biology
  • [ISO-abbreviation] Neuron Glia Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Ion Channels; 0 / Myelin Proteolipid Protein; 0 / Nerve Tissue Proteins; 0 / Proteolipids
  • [Number-of-references] 191
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93. Ueda K, Sakakibara S, Ohsaki E, Yada K: Lack of a mechanism for faithful partition and maintenance of the KSHV genome. Virus Res; 2006 Dec;122(1-2):85-94
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  • [Title] Lack of a mechanism for faithful partition and maintenance of the KSHV genome.
  • We cloned a bacmid containing the viral TR region from PEL cells and tested whether TR with LANA were sufficient for viral genome maintenance.
  • KSHV might confer a positive growth effect on infected PEL cells, but not on immortalized or transformed cells previously uninfected by KSHV.
  • [MeSH-minor] Antigens, Viral / physiology. Cell Line. Cloning, Molecular. Genes, Reporter. Genetic Vectors. Green Fluorescent Proteins / biosynthesis. Green Fluorescent Proteins / genetics. Humans. Microscopy, Fluorescence. Nuclear Proteins / physiology

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  • (PMID = 16920214.001).
  • [ISSN] 0168-1702
  • [Journal-full-title] Virus research
  • [ISO-abbreviation] Virus Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, Viral; 0 / DNA, Viral; 0 / Nuclear Proteins; 0 / enhanced green fluorescent protein; 0 / latency-associated nuclear antigen; 147336-22-9 / Green Fluorescent Proteins
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94. Kudla U, Milac AL, Qin L, Overmars H, Roze E, Holterman M, Petrescu AJ, Goverse A, Bakker J, Helder J, Smant G: Structural and functional characterization of a novel, host penetration-related pectate lyase from the potato cyst nematode Globodera rostochiensis. Mol Plant Pathol; 2007 May;8(3):293-305
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  • [Title] Structural and functional characterization of a novel, host penetration-related pectate lyase from the potato cyst nematode Globodera rostochiensis.
  • SUMMARY The cell wall, a strong extraprotoplasmic layer surrounding plant cells that mainly consists of a variety of polysaccharides, constitutes a major barrier for potential parasites.
  • Expression profiling of various life stages of the potato cyst nematode Globodera rostochiensis revealed a novel pectate lyase gene (Gr-pel2, 759 bp).
  • The Gr-PEL2 protein showed highest similarity to pectate lyases from the facultative plant-parasitic nematodes Bursaphelenchus mucronatus and B. xylophilus and the soil-inhabiting saprophytic Streptomyces and Frankia species (i.e.
  • Ca(2+) is known to be essential for pectate lyase activity, and the most likely calcium-binding site was identified in the Gr-PEL2 protein by combining homology modelling of the three-dimensional structure, site-directed mutagenesis and transient expression in leaves.
  • Our results underline the broad spectrum of pectate lyases and cell-wall-degrading enzymes necessary for successful parasitism by cyst nematodes.

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  • (PMID = 20507500.001).
  • [ISSN] 1364-3703
  • [Journal-full-title] Molecular plant pathology
  • [ISO-abbreviation] Mol. Plant Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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95. Brancaleoni GH, Lourenzoni MR, Degrève L: Study of the influence of ethanol on basic fibroblast growth factor structure. Genet Mol Res; 2006;5(2):350-72
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  • In order to better understand the mode of action of bFGF, particularly regarding the influence of ethanol on the biological activity of bFGF, three recombinant bFGF mutants were produced (M6B-bFGF, M1-bFGF and M1Q-bFGF).
  • In the present study, wild bFGF and these mutants were examined by molecular dynamics simulations in systems consisting of a solute molecule in ethanol solution at 298 K and physiological pH over 4.0 ns.

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  • (PMID = 16819715.001).
  • [ISSN] 1676-5680
  • [Journal-full-title] Genetics and molecular research : GMR
  • [ISO-abbreviation] Genet. Mol. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] 103107-01-3 / Fibroblast Growth Factor 2; 3K9958V90M / Ethanol
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96. Cotte-Rodríguez I, Justes DR, Nanita SC, Noll RJ, Mulligan CC, Sanders NL, Cooks RG: Analysis of gaseous toxic industrial compounds and chemical warfare agent simulants by atmospheric pressure ionization mass spectrometry. Analyst; 2006 Apr;131(4):579-89
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  • The suitability of atmospheric pressure chemical ionization mass spectrometry as sensing instrumentation for the real-time monitoring of low levels of toxic compounds is assessed, especially with respect to public safety applications.
  • Tandem MS methods were implemented in selected cases for improved selectivity, sensitivity, and limits of detection.
  • Limits of detection in the parts-per-billion and parts-per-trillion range were achieved for this set of analytes.
  • In all cases detection limits were well below the compounds' permissible exposure limits (PELs), even in the presence of added complex mixtures of alkanes.

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  • (PMID = 16568176.001).
  • [ISSN] 0003-2654
  • [Journal-full-title] The Analyst
  • [ISO-abbreviation] Analyst
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Air Pollutants; 0 / Chemical Warfare Agents
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97. Russo P, Catassi A, Cesario A, Imperatori A, Rotolo N, Fini M, Granone P, Dominioni L: Molecular mechanisms of hexavalent chromium-induced apoptosis in human bronchoalveolar cells. Am J Respir Cell Mol Biol; 2005 Dec;33(6):589-600
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  • Occupational Safety and Health Administration was obliged to reduce the permissible exposure limit (PEL), it was reported that U.S. workers continue to be exposed to dangerously high Cr(VI) levels.
  • In this study, we examined the role of p53 and target genes in a bronchoalveolar carcinoma isogenic cell line system and in primary human bronchial epithelial cells. p53-Negative parental H358 cell line, the same line in which the wild-type p53 expression vector (pC53-SN3) was introduced, and cells obtained from biopsies of human bronchus were exposed to chromate.
  • Induction of DNA strand breaks were evaluated by alkaline elution assay, and apoptosis was analyzed by gel ladder, annexin V-PI staining, and ELISA, whereas p53 and target genes were evaluated by Western blots.

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  • (PMID = 16166740.001).
  • [ISSN] 1044-1549
  • [Journal-full-title] American journal of respiratory cell and molecular biology
  • [ISO-abbreviation] Am. J. Respir. Cell Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / BBC3 protein, human; 0 / Carcinogens, Environmental; 0 / Proto-Oncogene Proteins; 0 / Tumor Suppressor Protein p53; 0 / bcl-2-Associated X Protein; 0R0008Q3JB / Chromium; 18540-29-9 / chromium hexavalent ion; 9007-43-6 / Cytochromes c; EC 3.4.22.- / CASP3 protein, human; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspases
  • [Other-IDs] NLM/ PMC2715333
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98. Adkins JN, Monroe ME, Auberry KJ, Shen Y, Jacobs JM, Camp DG 2nd, Vitzthum F, Rodland KD, Zangar RC, Smith RD, Pounds JG: A proteomic study of the HUPO Plasma Proteome Project's pilot samples using an accurate mass and time tag strategy. Proteomics; 2005 Aug;5(13):3454-66
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  • This analysis highlighted both known differences in serum and citrated plasma such as fibrinogens, and reproducible differences in peptide abundances from proteins such as soluble activin receptor-like kinase 7b and glycoprotein m6b.

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  • (PMID = 16052625.001).
  • [ISSN] 1615-9853
  • [Journal-full-title] Proteomics
  • [ISO-abbreviation] Proteomics
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / P41 RR018522; United States / NCI NIH HHS / CA / CA78722; United States / NCRR NIH HHS / RR / RR18522
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Blood Proteins; 0 / Ions; 0 / Peptides; 0 / Proteins; 0 / Proteome; 9001-32-5 / Fibrinogen; EC 3.4.21.4 / Trypsin
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