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1. Staal-Viliare A, Latger-Cannard V, Rault JP, Didion J, Grégoire MJ, Bologna S, Witz B, Jonveaux P, Lecompte T, Rio Y: [A case of de novo acute basophilic leukaemia: diagnostic criteria and review of the literature]. Ann Biol Clin (Paris); 2006 Jul-Aug;64(4):361-5
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  • [Title] [A case of de novo acute basophilic leukaemia: diagnostic criteria and review of the literature].
  • [Transliterated title] A propos d'un cas de leucémie à basophiles de novo: critères diagnostiques et revue de la littérature.
  • We report a case of a de novo acute basophilic leukaemia, revealed by an infectious pneumopathy in a 73 year old man.
  • The blood and bone marrow smears showed a mixture of undifferentiated blast cells and basophiloblasts (high nucleo-cytoplasmic ratio, coarse basophilic cytoplasmic granules), along with basophilic precursors and basophilic polymorphonuclears.
  • All the blasts were MPO negative but positive for the toluidine blue metachromatic coloration, which is considered as consistent with basophilic lineage.
  • Immunophenotypic studies showed myeloid blasts, without maturity marker, CD 117 negative and CD203 cytoplasmic positive, the latter known to be highly representative of the basophilic lineage.
  • This very clear-cut phenotype, associated with the morphology of cells, were arguments to ascertain the basophilic lineage of the blasts without the need of electron microscopic study.
  • This clinical prompted allows us to review the literature on acute basophilic leukaemia and to state on the different diagnostic criteria of this rare disorder.
  • [MeSH-major] Leukemia, Basophilic, Acute / blood. Leukemia, Basophilic, Acute / diagnosis

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  • (PMID = 16829481.001).
  • [ISSN] 0003-3898
  • [Journal-full-title] Annales de biologie clinique
  • [ISO-abbreviation] Ann. Biol. Clin. (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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2. Harata G, He F, Takahashi K, Hosono A, Kawase M, Kubota A, Hiramatsu M, Kaminogawa S: Bifidobacterium suppresses IgE-mediated degranulation of rat basophilic leukemia (RBL-2H3) cells. Microbiol Immunol; 2010;54(1):54-7
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  • [Title] Bifidobacterium suppresses IgE-mediated degranulation of rat basophilic leukemia (RBL-2H3) cells.
  • Sixteen heat-killed bifidobacteria isolated from human intestine and a probiotic strain Lactobacillus GG were tested for their ability to influence IgE-mediated degranulation of rat basophilic leukemia (RBL-2H3) cells in vitro.
  • [MeSH-major] Basophils / immunology. Bifidobacterium / physiology. Immunoglobulin E / immunology. Leukemia, Basophilic, Acute / immunology

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  • (PMID = 20055943.001).
  • [ISSN] 0385-5600
  • [Journal-full-title] Microbiology and immunology
  • [ISO-abbreviation] Microbiol. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 37341-29-0 / Immunoglobulin E
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3. Kato N, Nakanishi M, Hirashima N: Flotillin-1 regulates IgE receptor-mediated signaling in rat basophilic leukemia (RBL-2H3) cells. J Immunol; 2006 Jul 1;177(1):147-54
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  • [Title] Flotillin-1 regulates IgE receptor-mediated signaling in rat basophilic leukemia (RBL-2H3) cells.
  • Cross-linking of high-affinity IgE receptors by multivalent Ag on mast cells (rat basophilic leukemia (RBL)-2H3) induces the phosphorylation of ITAM motifs of an IgE receptor by Src family tyrosine kinase, Lyn.
  • We obtained flotillin-1 knockdown (KD)(2) rat basophilic leukemia (RBL)-2H3 cells, which express a low level of flotillin-1.
  • [MeSH-minor] Animals. Calcium / metabolism. Calcium Signaling / physiology. Cell Degranulation / physiology. Cell Line, Tumor. Enzyme Activation / physiology. Extracellular Signal-Regulated MAP Kinases / metabolism. Leukemia, Basophilic, Acute / enzymology. Leukemia, Basophilic, Acute / immunology. Leukemia, Basophilic, Acute / metabolism. Membrane Microdomains / enzymology. Membrane Microdomains / immunology. Membrane Microdomains / metabolism. Phosphorylation. Rats. Transfection. Tyrosine / metabolism. src-Family Kinases / metabolism

  • Gene Ontology. gene/protein/disease-specific - Gene Ontology annotations from this paper .
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  • (PMID = 16785509.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / Receptors, IgE; 0 / flotillins; 42HK56048U / Tyrosine; EC 2.7.10.2 / lyn protein-tyrosine kinase; EC 2.7.10.2 / src-Family Kinases; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; SY7Q814VUP / Calcium
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4. Shin SY, Koo SH, Kwon KC, Park JW, Ko CS, Jo DY: Monosomy 7 as the sole abnormality of an acute basophilic leukemia. Cancer Genet Cytogenet; 2007 Jan 15;172(2):168-71
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  • [Title] Monosomy 7 as the sole abnormality of an acute basophilic leukemia.
  • We report the case of a 72-year-old man who had the very rare disease acute basophilic leukemia with the sole chromosomal finding of a monosomy 7.
  • Cytogenetic study revealed monosomy 7 in all metaphase cells, and this finding was confirmed by fluorescence in situ hybridization.
  • To our knowledge, the case reported here is the first to have basophilic leukemia with monosomy 7 as the only chromosome abnormality.
  • [MeSH-major] Chromosomes, Human, Pair 7 / genetics. Leukemia, Basophilic, Acute / genetics. Monosomy / diagnosis. Monosomy / genetics
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male

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  • (PMID = 17213028.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Bitto E, Bingman CA, Robinson H, Allard ST, Wesenberg GE, Phillips GN Jr: The structure at 2.5 A resolution of human basophilic leukemia-expressed protein BLES03. Acta Crystallogr Sect F Struct Biol Cryst Commun; 2005 Sep 1;61(Pt 9):812-7
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  • [Title] The structure at 2.5 A resolution of human basophilic leukemia-expressed protein BLES03.
  • The crystal structure of the human basophilic leukemia-expressed protein (BLES03, p5326, Hs.433573) was determined by single-wavelength anomalous diffraction and refined to an R factor of 18.8% (Rfree = 24.5%) at 2.5 A resolution.

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  • (PMID = 16511166.001).
  • [ISSN] 1744-3091
  • [Journal-full-title] Acta crystallographica. Section F, Structural biology and crystallization communications
  • [ISO-abbreviation] Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / P50 GM064598; United States / NIGMS NIH HHS / GM / P50 GM64598
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / C11orf68 protein, human; 0 / Eukaryotic Initiation Factor-4E; 0 / Neoplasm Proteins
  • [Other-IDs] NLM/ PMC1978119
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6. Spendier K, Carroll-Portillo A, Lidke KA, Wilson BS, Timlin JA, Thomas JL: Distribution and dynamics of rat basophilic leukemia immunoglobulin E receptors (FcepsilonRI) on planar ligand-presenting surfaces. Biophys J; 2010 Jul 21;99(2):388-97
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  • [Title] Distribution and dynamics of rat basophilic leukemia immunoglobulin E receptors (FcepsilonRI) on planar ligand-presenting surfaces.
  • We have quantified the spatiotemporal dynamics of the redistribution of immunoglobulin E-loaded receptors (IgE-FcepsilonRI) on rat basophilic leukemia-2H3 mast cells in contact with fluid and gel-phase membranes displaying ligands for immunoglobulin E, using total internal reflection fluorescence microscopy.
  • [MeSH-major] 1,2-Dipalmitoylphosphatidylcholine / metabolism. Cell Membrane / metabolism. Leukemia, Basophilic, Acute / metabolism. Leukemia, Basophilic, Acute / pathology. Phosphatidylcholines / metabolism. Receptors, IgE / metabolism

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  • [Copyright] Copyright (c) 2010 Biophysical Society. Published by Elsevier Inc. All rights reserved.
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  • (PMID = 20643056.001).
  • [ISSN] 1542-0086
  • [Journal-full-title] Biophysical journal
  • [ISO-abbreviation] Biophys. J.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / R01 AI051575; United States / NIAID NIH HHS / AI / R01 AI051575-08
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ligands; 0 / Phosphatidylcholines; 0 / Receptors, IgE; 2644-64-6 / 1,2-Dipalmitoylphosphatidylcholine; TE895536Y5 / 1-palmitoyl-2-oleoylphosphatidylcholine
  • [Other-IDs] NLM/ PMC2905106
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7. Yasui Y, Sasao E, Sakata M, Matsui N, Fukuishi N, Akagi R, Akagi M: Upregulation of heme oxygenase-1 by degranulation in rat basophilic leukemia cells. Biol Pharm Bull; 2007 Mar;30(3):443-6
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  • [Title] Upregulation of heme oxygenase-1 by degranulation in rat basophilic leukemia cells.
  • To trigger degranulation, rat basophilic leukemia (RBL)-2H3 cells were passively sensitized using an antiserum collected from ovalbumin (OA) immunized-Brown Norway rats, and the cells were stimulated by treatment with OA.
  • [MeSH-major] Cell Degranulation. Heme Oxygenase-1 / metabolism. Leukemia, Basophilic, Acute / metabolism

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  • (PMID = 17329835.001).
  • [ISSN] 0918-6158
  • [Journal-full-title] Biological & pharmaceutical bulletin
  • [ISO-abbreviation] Biol. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / 2',7'-dichlorodihydrofluorescein diacetate; 0 / Azo Compounds; 0 / Enzyme Inhibitors; 0 / Fluoresceins; 0 / Free Radical Scavengers; 0 / Metalloporphyrins; 0 / RNA, Messenger; 0 / Reactive Oxygen Species; 0KAE1U0G7Q / tin mesoporphyrin; 6226-79-5 / ponceau S; 9006-59-1 / Ovalbumin; EC 1.14.99.3 / Heme Oxygenase-1; WYQ7N0BPYC / Acetylcysteine
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8. Pidala J, Pinilla-Ibarz J, Cualing HD: A case of acute basophilic leukemia arising from chronic myelogenous leukemia with development of t(7;8)(q32;q13). Cancer Genet Cytogenet; 2008 Apr 1;182(1):46-9
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  • [Title] A case of acute basophilic leukemia arising from chronic myelogenous leukemia with development of t(7;8)(q32;q13).
  • Acute basophilic leukemia (ABL) is an uncommon form of acute myelogenous leukemia recently recognized as a distinct entity in the World Health Organization classification of myeloid malignancies.
  • A case is presented of ABL arising from chronic myelogenous leukemia with development of t(7;8)(q32;q13).
  • [MeSH-major] Chromosomes, Human, Pair 7. Chromosomes, Human, Pair 8. Leukemia, Basophilic, Acute / genetics. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications. Translocation, Genetic


9. Moser AM, Manor E, Narkis G, Kapelushnik J: Imatinib resistant chronic myelogenous leukemia, BCR-ABL positive by chromosome and FISH analyses but negative by PCR, in a child progressing to acute basophilic leukemia: cytogenetic follow-up. Cancer Genet Cytogenet; 2006 Oct 1;170(1):54-7
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  • [Title] Imatinib resistant chronic myelogenous leukemia, BCR-ABL positive by chromosome and FISH analyses but negative by PCR, in a child progressing to acute basophilic leukemia: cytogenetic follow-up.
  • The case of an 11-year-old child with adult-type chronic myeloid leukemia, Philadelphia (BCR-ABL) positive, reverse transcription-polymerase chain reaction negative for the major, minor, and micro breakpoints is presented.
  • In the course of 3 years, the child failed to respond to treatment with hydroxyurea, refused all therapy for 6 months, was intolerant to alpha-interferon and progressed, while on imatinib, to acute basophilic leukemia.
  • It is not clear to what extent the several factors (undefined BCR-ABL breakpoint, treatment avoidance, and initial treatment choices, alone or in combination) played a role in the imatinib relapse and resistance and in the disease progression.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Genes, abl. Leukemia, Basophilic, Acute / surgery. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics. Piperazines / therapeutic use. Pyrimidines / therapeutic use
  • [MeSH-minor] Benzamides. Bone Marrow Transplantation. Child. Disease Progression. Drug Resistance, Neoplasm. Humans. Imatinib Mesylate. Immunophenotyping. In Situ Hybridization, Fluorescence. Male. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 16965955.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
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10. [Picture in clinical hematology. Acute basophilic leukemia]. Rinsho Ketsueki; 2007 Jan;48(1):1
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  • [Title] [Picture in clinical hematology. Acute basophilic leukemia].
  • [MeSH-major] Leukemia, Basophilic, Acute / pathology

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  • (PMID = 17313070.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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11. Ljubić N, Lang N, Skelin IK, Lasan R, Dominis M, Perković L, Zupanić-Krmek D, Grgurević-Batinica A: Klinefelter syndrome and acute basophilic leukaemia--case report. Coll Antropol; 2010 Jun;34(2):657-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Klinefelter syndrome and acute basophilic leukaemia--case report.
  • Patients with 47, XXY karyotype (Klinefelter syndrome) appear to have increased risk of developing cancer, especially male breast cancer, germ cell tumours and non Hodgkin lymphomas, but rarely acute myeloid leukaemia.
  • We report a patient with acute basophilic leukaemia with 47, XXY karyotype in both the tumour and constitutional cells.
  • Acute basophilic leukaemia is very rare disease comprising less than 1% of all acute myeloid leukaemias.
  • Morphological characteristic of leukaemic blast cells is moderately basophilic cytoplasm containing a variable number of coarse basophilic granules.
  • There is no consistent chromosomal abnormality identified in this leukaemia.
  • This is the first reported case of acute basophilic leukaemia in patient with Klinefelter syndrome.
  • In this article the medical history of the patient is given and the possible connection between Klinefelter syndrome and acute myeloid leukaemia is discussed.
  • [MeSH-major] Klinefelter Syndrome / complications. Leukemia, Basophilic, Acute / complications

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  • (PMID = 20698148.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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12. Lichtman MA, Segel GB: Uncommon phenotypes of acute myelogenous leukemia: basophilic, mast cell, eosinophilic, and myeloid dendritic cell subtypes: a review. Blood Cells Mol Dis; 2005 Nov-Dec;35(3):370-83
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  • [Title] Uncommon phenotypes of acute myelogenous leukemia: basophilic, mast cell, eosinophilic, and myeloid dendritic cell subtypes: a review.
  • The potential of the transformed (leukemic) multipotential hematopoietic cell to differentiate and mature along any myeloid lineage forms the basis for the phenotypic classification of acute and chronic myelogenous leukemia.
  • Although most cases of leukemia can be classified phenotypically by the dominant lineage expressed, the genotype within each phenotype is heterogeneous.
  • The least common AML phenotypes are a reflection of the least common blood or marrow cell lineages: acute basophilic, acute mast cell, acute eosinophilic, and acute myeloid dendritic cell leukemia.
  • We discuss the features of these uncommon phenotypes and review the criteria used for their diagnosis.
  • [MeSH-major] Basophils / pathology. Dendritic Cells / pathology. Eosinophils / pathology. Leukemia, Myeloid, Acute / genetics. Leukemia, Myeloid, Acute / pathology. Mast Cells / pathology. Myeloid Cells / pathology


13. Itoh T, Ohguchi K, Iinuma M, Nozawa Y, Akao Y: Inhibitory effects of polymethoxy flavones isolated from Citrus reticulate on degranulation in rat basophilic leukemia RBL-2H3: enhanced inhibition by their combination. Bioorg Med Chem; 2008 Aug 15;16(16):7592-8
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  • [Title] Inhibitory effects of polymethoxy flavones isolated from Citrus reticulate on degranulation in rat basophilic leukemia RBL-2H3: enhanced inhibition by their combination.
  • It has been reported that flavonoids isolated from several Citrus have been shown to suppress the degranulation as inferred by histamine release in rat basophilic leukemia RBL-2H3 cells.
  • [MeSH-minor] Animals. Calcium / antagonists & inhibitors. Calcium / metabolism. Cell Line, Tumor. Enzyme Activation / drug effects. Histamine Release / drug effects. Immunoblotting. Intracellular Signaling Peptides and Proteins / antagonists & inhibitors. Intracellular Signaling Peptides and Proteins / metabolism. Leukemia, Basophilic, Acute. Phospholipase C gamma / antagonists & inhibitors. Phospholipase C gamma / metabolism. Protein-Tyrosine Kinases / antagonists & inhibitors. Protein-Tyrosine Kinases / metabolism. Rats. Reactive Oxygen Species / metabolism. Receptors, IgG / metabolism. Signal Transduction / drug effects. src-Family Kinases / antagonists & inhibitors. src-Family Kinases / metabolism

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  • (PMID = 18656366.001).
  • [ISSN] 1464-3391
  • [Journal-full-title] Bioorganic & medicinal chemistry
  • [ISO-abbreviation] Bioorg. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Flavones; 0 / Intracellular Signaling Peptides and Proteins; 0 / Reactive Oxygen Species; 0 / Receptors, IgG; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Syk kinase; EC 2.7.10.2 / lyn protein-tyrosine kinase; EC 2.7.10.2 / src-Family Kinases; EC 3.1.4.3 / Phospholipase C gamma; SY7Q814VUP / Calcium
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14. Kokandakar HR, Tembhare PR, Mamoon A, Mulay VM, Bhople KS: Acute basophilic leukaemia: a case report. Indian J Pathol Microbiol; 2007 Apr;50(2):443-6
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  • [Title] Acute basophilic leukaemia: a case report.
  • Acute basophilic leukaemia is an uncommon form of acute leukaemia, rarely occurring as de novo disease.
  • Due to rarity of the disease, consistent diagnostic criteria for the identification of this entity still remain the topic of discussion.
  • We present a case of acute basophilic leukaemia with (11q23)-MLL gene rearrangement, in an 18-year-old male with review of literature and discussion of diagnostic criteria.
  • [MeSH-major] Leukemia, Basophilic, Acute / diagnosis
  • [MeSH-minor] Adolescent. Coloring Agents. Gene Rearrangement. Histone-Lysine N-Methyltransferase. Humans. Male. Myeloid-Lymphoid Leukemia Protein / genetics. Staining and Labeling. Tolonium Chloride

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  • (PMID = 17883105.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / MLL protein, human; 149025-06-9 / Myeloid-Lymphoid Leukemia Protein; 15XUH0X66N / Tolonium Chloride; EC 2.1.1.43 / Histone-Lysine N-Methyltransferase
  • [Number-of-references] 11
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15. Tiede LM, Nichols MG: Photobleaching of reduced nicotinamide adenine dinucleotide and the development of highly fluorescent lesions in rat basophilic leukemia cells during multiphoton microscopy. Photochem Photobiol; 2006 May-Jun;82(3):656-64
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  • [Title] Photobleaching of reduced nicotinamide adenine dinucleotide and the development of highly fluorescent lesions in rat basophilic leukemia cells during multiphoton microscopy.
  • The loss of fluorescence because of multiphoton photobleaching was measured by repetitively imaging individual planes within rat basophilic leukemia cells.
  • [MeSH-major] Leukemia, Basophilic, Acute / pathology. NAD / radiation effects. Photobleaching

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  • (PMID = 16426080.001).
  • [ISSN] 0031-8655
  • [Journal-full-title] Photochemistry and photobiology
  • [ISO-abbreviation] Photochem. Photobiol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / F32 CA 72225; United States / NCRR NIH HHS / RR / RR04224
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0U46U6E8UK / NAD
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16. Yang W, Chen J, Zhou L: Effects of shear stress on intracellular calcium change and histamine release in rat basophilic leukemia (RBL-2H3) cells. J Environ Pathol Toxicol Oncol; 2009;28(3):223-30
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  • [Title] Effects of shear stress on intracellular calcium change and histamine release in rat basophilic leukemia (RBL-2H3) cells.
  • In the present work, a mast cell line (rat basophilic leukemia cells, RBL-2H3) was used in vitro to study cellular responses to the stimulus of shear stress generated by a rotating rotor in a cell dish.
  • [MeSH-minor] Animals. Calcium Channels / drug effects. Calcium Channels / physiology. Calcium Signaling / drug effects. Calcium Signaling / physiology. Cell Line, Tumor. Cell Membrane / drug effects. Cell Membrane / metabolism. Indicators and Reagents / pharmacology. Leukemia, Basophilic, Acute. Microcirculation. Rats. Ruthenium Red / pharmacology. Stress, Mechanical. TRPV Cation Channels / antagonists & inhibitors. TRPV Cation Channels / metabolism

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  • (PMID = 19888909.001).
  • [ISSN] 2162-6537
  • [Journal-full-title] Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer
  • [ISO-abbreviation] J. Environ. Pathol. Toxicol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium Channels; 0 / Indicators and Reagents; 0 / TRPV Cation Channels; 0 / Trpv4 protein, rat; 11103-72-3 / Ruthenium Red; 820484N8I3 / Histamine; SY7Q814VUP / Calcium
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17. Chan JH, Liao W, Lau HY, Wong WS: Gab2 antisense oligonucleotide blocks rat basophilic leukemic cell functions. Int Immunopharmacol; 2007 Jul;7(7):937-44
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  • [Title] Gab2 antisense oligonucleotide blocks rat basophilic leukemic cell functions.
  • The present study aimed to investigate the pharmacological effects of an antisense oligonucleotide (ASO) targeted at Gab2 on the immune responses of rat basophilic leukemic (RBL)-2H3 cells.
  • [MeSH-major] Basophils / immunology. Leukemia, Basophilic, Acute / drug therapy. Leukemia, Basophilic, Acute / immunology. Oligonucleotides, Antisense / pharmacology. Phosphoproteins / genetics. RNA, Messenger / metabolism. Signal Transduction / genetics

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  • (PMID = 17499196.001).
  • [ISSN] 1567-5769
  • [Journal-full-title] International immunopharmacology
  • [ISO-abbreviation] Int. Immunopharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Cytokines; 0 / Fibronectins; 0 / Gab2 protein, rat; 0 / Oligonucleotides, Antisense; 0 / Phosphoproteins; 0 / RNA, Messenger; 0 / Receptors, IgE; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
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18. Itoh T, Ohguchi K, Iinuma M, Nozawa Y, Akao Y: Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation. Bioorg Med Chem; 2008 Apr 15;16(8):4500-8
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  • [Title] Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation.
  • In this study, we examined the effect of xanthones on cell degranulation in rat basophilic leukemia RBL-2H3 cells.
  • [MeSH-major] Cell Degranulation / drug effects. Garcinia mangostana / chemistry. Leukemia, Basophilic, Acute / pathology. Xanthones / chemistry. Xanthones / pharmacology

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  • (PMID = 18328716.001).
  • [ISSN] 1464-3391
  • [Journal-full-title] Bioorganic & medicinal chemistry
  • [ISO-abbreviation] Bioorg. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Intracellular Signaling Peptides and Proteins; 0 / Reactive Oxygen Species; 0 / Receptors, IgE; 0 / Xanthones; 37341-29-0 / Immunoglobulin E; 820484N8I3 / Histamine; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Syk kinase; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; EC 3.1.4.3 / Phospholipase C gamma; SY7Q814VUP / Calcium
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19. Ozawa T, Nakata K, Mizuno K, Yakura H: Negative autoregulation of Src homology region 2-domain-containing phosphatase-1 in rat basophilic leukemia-2H3 cells. Int Immunol; 2007 Sep;19(9):1049-61
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  • [Title] Negative autoregulation of Src homology region 2-domain-containing phosphatase-1 in rat basophilic leukemia-2H3 cells.
  • When phosphatase-inactive SHP-1 was over-expressed in rat basophilic leukemia (RBL)-2H3 cells, tyrosine phosphorylation of a 68-kDa protein was enhanced before and after FcepsilonRI aggregation.
  • [MeSH-major] Leukemia, Basophilic, Acute / immunology. Protein Tyrosine Phosphatase, Non-Receptor Type 6 / immunology

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  • (PMID = 17675340.001).
  • [ISSN] 0953-8178
  • [Journal-full-title] International immunology
  • [ISO-abbreviation] Int. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cytokines; 0 / Intracellular Signaling Peptides and Proteins; 0 / Receptors, IgE; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Syk kinase; EC 2.7.10.2 / lyn protein-tyrosine kinase; EC 2.7.10.2 / src-Family Kinases; EC 2.7.11.24 / Mitogen-Activated Protein Kinases; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 6; EC 3.1.3.48 / Ptpn6 protein, rat
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20. Hanashiro K, Sunagawa M, Nakasone T, Nakamura M, Kosugi T: Inhibition of IgE-mediated phosphorylation of FcepsilonRIgamma protein by antiallergic drugs in rat basophilic leukemia (RBL-2H3) cells: a novel action of antiallergic drugs. Int Immunopharmacol; 2007 Jul;7(7):994-1002
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  • [Title] Inhibition of IgE-mediated phosphorylation of FcepsilonRIgamma protein by antiallergic drugs in rat basophilic leukemia (RBL-2H3) cells: a novel action of antiallergic drugs.
  • We examined the effect of antiallergic drugs, azelastine and epinastine, on the expression of FcepsilonRIalpha, beta, and gamma chains and phosphorylation of the gamma chains in rat basophilic leukemia (RBL-2H3) cells.
  • [MeSH-major] Anti-Allergic Agents / pharmacology. Dibenzazepines / pharmacology. Imidazoles / pharmacology. Immunoglobulin E / metabolism. Leukemia, Basophilic, Acute / metabolism. Phthalazines / pharmacology. Receptors, IgE / drug effects. Receptors, IgE / metabolism

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  • (PMID = 17499203.001).
  • [ISSN] 1567-5769
  • [Journal-full-title] International immunopharmacology
  • [ISO-abbreviation] Int. Immunopharmacol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Dibenzazepines; 0 / Imidazoles; 0 / Phthalazines; 0 / Receptors, IgE; 37341-29-0 / Immunoglobulin E; 42HK56048U / Tyrosine; Q13WX941EF / epinastine; ZQI909440X / azelastine
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21. Okoshi Y, Tahara-Hanaoka S, Nakahashi C, Honda S, Miyamoto A, Kojima H, Nagasawa T, Shibuya K, Shibuya A: Requirement of the tyrosines at residues 258 and 270 of MAIR-I in inhibitory effect on degranulation from basophilic leukemia RBL-2H3. Int Immunol; 2005 Jan;17(1):65-72
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  • [Title] Requirement of the tyrosines at residues 258 and 270 of MAIR-I in inhibitory effect on degranulation from basophilic leukemia RBL-2H3.
  • Here, we demonstrate that the transfectant of rat basophil leukemia RBL-2H3 expressing wild-type MAIR-I is tyrosine phosphorylated and recruits SHP-1 and SHIP upon cross-linking of MAIR-I.
  • [MeSH-minor] Amino Acid Substitution. Animals. Antibodies, Monoclonal / pharmacology. Cell Line, Tumor. Immunoglobulin E / immunology. Leukemia, Basophilic, Acute. Mutation / genetics. Phosphorylation. Protein Tyrosine Phosphatases / metabolism. Rats


22. Olson FJ, Ludowyke RI, Karlsson NG: Discovery and identification of serine and threonine phosphorylated proteins in activated mast cells: implications for regulation of protein synthesis in the rat basophilic leukemia mast cell line RBL-2H3. J Proteome Res; 2009 Jun;8(6):3068-77
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  • [Title] Discovery and identification of serine and threonine phosphorylated proteins in activated mast cells: implications for regulation of protein synthesis in the rat basophilic leukemia mast cell line RBL-2H3.
  • This study aimed to identify proteins phosphorylated by serine or threonine kinases in the early stages of mast cell activation, using the rat basophilic leukemia cell line RBL-2H3 as a model system.
  • [MeSH-major] Leukemia, Basophilic, Acute / metabolism. Mast Cells / metabolism. Phosphoproteins / metabolism. Phosphoserine / metabolism. Phosphothreonine / metabolism

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  • (PMID = 19317463.001).
  • [ISSN] 1535-3893
  • [Journal-full-title] Journal of proteome research
  • [ISO-abbreviation] J. Proteome Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Peptide Elongation Factor 2; 0 / Phosphoproteins; 1114-81-4 / Phosphothreonine; 17885-08-4 / Phosphoserine; EC 3.6.4.1 / Myosins
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23. Yamada P, Zarrouk M, Kawasaki K, Isoda H: Inhibitory effect of various Tunisian olive oils on chemical mediator release and cytokine production by basophilic cells. J Ethnopharmacol; 2008 Mar 5;116(2):279-87
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  • [Title] Inhibitory effect of various Tunisian olive oils on chemical mediator release and cytokine production by basophilic cells.
  • To investigate the antiallergic effect of virgin olive oil samples from five principal olive varieties grown in various regions of Tunisia, we used the type I allergy reaction model using rat basophilic leukemia (RBL-2H3) cells and different dilutions of olive oil samples to determine beta-hexosaminidase release inhibition at two different response stages.
  • Moreover, we investigated the effect of olive oil samples on histamine release and production of cytokines by activated human basophilic (KU812) cells.
  • [MeSH-major] Leukemia, Basophilic, Acute / metabolism. Plant Oils / pharmacology. Tumor Necrosis Factor-alpha / biosynthesis

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  • (PMID = 18178046.001).
  • [ISSN] 0378-8741
  • [Journal-full-title] Journal of ethnopharmacology
  • [ISO-abbreviation] J Ethnopharmacol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Inflammation Mediators; 0 / Olive Oil; 0 / Plant Oils; 0 / Tumor Necrosis Factor-alpha; 207137-56-2 / Interleukin-4; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
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24. Itoh T, Oyama M, Takimoto N, Kato C, Nozawa Y, Akao Y, Iinuma M: Inhibitory effects of sesquiterpene lactones isolated from Eupatorium chinense L. on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice. Bioorg Med Chem; 2009 Apr 15;17(8):3189-97
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  • [Title] Inhibitory effects of sesquiterpene lactones isolated from Eupatorium chinense L. on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice.
  • Sesquiterpene lactones (SQTLs) have been shown to suppress the degranulation as inferred by histamine release in rat basophilic leukemia RBL-2H3 cells.
  • [MeSH-minor] Animals. Basophil Degranulation Test. Calcium / metabolism. Histamine Release / drug effects. Leukemia, Basophilic, Acute / immunology. Leukemia, Basophilic, Acute / pathology. Magnetic Resonance Spectroscopy. Mice. Rats. Reactive Oxygen Species. Signal Transduction / drug effects

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  • (PMID = 19318257.001).
  • [ISSN] 1464-3391
  • [Journal-full-title] Bioorganic & medicinal chemistry
  • [ISO-abbreviation] Bioorg. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Lactones; 0 / Reactive Oxygen Species; 0 / Sesquiterpenes; 37341-29-0 / Immunoglobulin E; SY7Q814VUP / Calcium
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25. Billington RA, Bellomo EA, Floriddia EM, Erriquez J, Distasi C, Genazzani AA: A transport mechanism for NAADP in a rat basophilic cell line. FASEB J; 2006 Mar;20(3):521-3
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  • [Title] A transport mechanism for NAADP in a rat basophilic cell line.
  • Indeed, in RBL-2H3 cells, a rat basophilic cell line, and in SK-N-BE cells, a neuroblastoma cell line, [32P]NAADP is efficiently transported inside cells.
  • [MeSH-minor] Animals. Autocrine Communication. Biological Transport. Calcium / physiology. Calcium Signaling / drug effects. Cell Line, Tumor. Dipyridamole / pharmacology. Leukemia, Basophilic, Acute / pathology. Neuroblastoma / pathology. Paracrine Communication. Rats. Second Messenger Systems. Sodium / physiology

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  • (PMID = 16403787.001).
  • [ISSN] 1530-6860
  • [Journal-full-title] FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • [ISO-abbreviation] FASEB J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / nicotinic acid 1,N(6)-etheno-2-azaadenine dinucleotide phosphate; 53-59-8 / NADP; 5502-96-5 / NAADP; 64ALC7F90C / Dipyridamole; 9NEZ333N27 / Sodium; SY7Q814VUP / Calcium
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26. Chen R, Chen JY, Zhou LW: Metabolic patterns (NAD(P)H) in rat basophilic leukemia (RBL-2H3) cells and human hepatocellular carcinoma (Hep G2) cells with autofluorescence imaging. Ultrastruct Pathol; 2008 Sep-Oct;32(5):193-8
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  • [Title] Metabolic patterns (NAD(P)H) in rat basophilic leukemia (RBL-2H3) cells and human hepatocellular carcinoma (Hep G2) cells with autofluorescence imaging.
  • In this work, the dynamic NAD(P)H distributions in rat basophilic leukemia (RBL-2H3) and human hepatocellular carcinoma (Hep G2) cells were studied by imaging the autofluorescence of cellular NAD(P)H with a sensitive CCD detector in a confocal microscope.
  • [MeSH-major] Carcinoma, Hepatocellular / metabolism. Leukemia, Basophilic, Acute / metabolism. Liver Neoplasms / metabolism. Microscopy, Confocal. NADP / metabolism

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  • (PMID = 18958792.001).
  • [ISSN] 1521-0758
  • [Journal-full-title] Ultrastructural pathology
  • [ISO-abbreviation] Ultrastruct Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 53-59-8 / NADP
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27. Vonakis BM, Gibbons SP Jr, Rotté MJ, Brothers EA, Kim SC, Chichester K, MacDonald SM: Regulation of rat basophilic leukemia-2H3 mast cell secretion by a constitutive Lyn kinase interaction with the high affinity IgE receptor (Fc epsilon RI). J Immunol; 2005 Oct 1;175(7):4543-54
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  • [Title] Regulation of rat basophilic leukemia-2H3 mast cell secretion by a constitutive Lyn kinase interaction with the high affinity IgE receptor (Fc epsilon RI).
  • In the current study, we stably transfected the unique domain of Lyn into rat basophilic leukemia-2H3 mast cells and examined the consequences on Fc epsilonRI-induced signal transduction and mediator secretion to further define the role of the unique domain of Lyn in mast cell secretion.
  • In rat basophilic leukemia-2H3 cells, Lyn thus plays a dual role by positively regulating Fc epsilonRI phosphorylation and degranulation while negatively regulating LTC4 production.
  • [MeSH-minor] Animals. Calcium / metabolism. Cell Line, Tumor. Cell Membrane / physiology. Enzyme Precursors / physiology. Histamine / metabolism. Intracellular Signaling Peptides and Proteins. Kinetics. Leukemia, Basophilic, Acute / metabolism. Mice. Phosphoproteins / physiology. Phosphorylation. Protein Structure, Tertiary / genetics. Protein-Tyrosine Kinases / physiology. Rats. Signal Transduction / physiology. Transfection. Tumor Necrosis Factor-alpha / biosynthesis. Tyrosine / metabolism

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  • (PMID = 16177098.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / K22 AI49288; United States / NIAID NIH HHS / AI / R01 AI32651
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Enzyme Precursors; 0 / Gab2 protein, rat; 0 / Intracellular Signaling Peptides and Proteins; 0 / Phosphoproteins; 0 / Receptors, IgE; 0 / Tumor Necrosis Factor-alpha; 42HK56048U / Tyrosine; 820484N8I3 / Histamine; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Syk kinase; EC 2.7.10.2 / lyn protein-tyrosine kinase; EC 2.7.10.2 / src-Family Kinases; SY7Q814VUP / Calcium
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28. Evans NE, Forth MK, Simpson AK, Mason MJ: Inhibition by calyculin A and okadaic acid of the Ca(2+) release-activated Ca(2+) entry pathway in rat basophilic leukemia cells: evidence for regulation by type 1/2A serine/threonine phosphatase activity. Biochim Biophys Acta; 2005 Dec 10;1718(1-2):32-43
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  • [Title] Inhibition by calyculin A and okadaic acid of the Ca(2+) release-activated Ca(2+) entry pathway in rat basophilic leukemia cells: evidence for regulation by type 1/2A serine/threonine phosphatase activity.
  • Using a combination of fluorescence measurements of intracellular Ca(2+) ion concentration ([Ca(2+)](i)) and membrane potential we have investigated the sensitivity to serine/threonine phosphatase inhibition of Ca(2+) entry stimulated by activation of the Ca(2+) release-activated Ca(2+) (CRAC) entry pathway in rat basophilic leukemia cells.
  • [MeSH-minor] Animals. Boron Compounds / pharmacology. Cations, Divalent / metabolism. Cells, Cultured. Ion Transport / drug effects. Leukemia, Basophilic, Acute. Manganese / metabolism. Membrane Potentials / drug effects. Protein Phosphatase 1. Rats. Thapsigargin / pharmacology

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  • (PMID = 16297373.001).
  • [ISSN] 0006-3002
  • [Journal-full-title] Biochimica et biophysica acta
  • [ISO-abbreviation] Biochim. Biophys. Acta
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / 2-aminoethoxydiphenyl borate; 0 / Boron Compounds; 0 / Cations, Divalent; 0 / Enzyme Inhibitors; 0 / Oxazoles; 101932-71-2 / calyculin A; 1W21G5Q4N2 / Okadaic Acid; 42Z2K6ZL8P / Manganese; 67526-95-8 / Thapsigargin; EC 3.1.3.16 / Phosphoprotein Phosphatases; EC 3.1.3.16 / Protein Phosphatase 1; SY7Q814VUP / Calcium
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29. Kobayashi S, Tanabe S: Evaluation of the anti-allergic activity of Citrus unshiu using rat basophilic leukemia RBL-2H3 cells as well as basophils of patients with seasonal allergic rhinitis to pollen. Int J Mol Med; 2006 Mar;17(3):511-5
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  • [Title] Evaluation of the anti-allergic activity of Citrus unshiu using rat basophilic leukemia RBL-2H3 cells as well as basophils of patients with seasonal allergic rhinitis to pollen.
  • To examine this anti-allergic mechanism in detail, we next used rat basophlilic leukemia RBL-2H3 cells.
  • [MeSH-major] Anti-Allergic Agents / therapeutic use. Basophils / drug effects. Citrus. Leukemia, Basophilic, Acute / immunology. Phytotherapy. Pollen / immunology. Rhinitis, Allergic, Seasonal / drug therapy

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  • (PMID = 16465400.001).
  • [ISSN] 1107-3756
  • [Journal-full-title] International journal of molecular medicine
  • [ISO-abbreviation] Int. J. Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Flavonoids; 0 / Plant Preparations; 37341-29-0 / Immunoglobulin E; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
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30. Qu X, Li Y, Liu J, Xu L, Zhang Y, Hu X, Hou K, Liu Y: Cbl-b promotes chemotherapy-induced apoptosis in rat basophilic leukemia cells by suppressing PI3K/Akt activation and enhancing MEK/ERK activation. Mol Cell Biochem; 2010 Jul;340(1-2):107-14
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  • [Title] Cbl-b promotes chemotherapy-induced apoptosis in rat basophilic leukemia cells by suppressing PI3K/Akt activation and enhancing MEK/ERK activation.
  • [MeSH-major] Adaptor Proteins, Signal Transducing / metabolism. Antimetabolites, Antineoplastic / pharmacology. Antineoplastic Agents, Phytogenic / pharmacology. Apoptosis / drug effects. Extracellular Signal-Regulated MAP Kinases / metabolism. Leukemia, Basophilic, Acute / enzymology. Mitogen-Activated Protein Kinase Kinases / metabolism. Phosphatidylinositol 3-Kinases / metabolism. Proto-Oncogene Proteins c-akt / metabolism. Proto-Oncogene Proteins c-cbl / metabolism

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  • (PMID = 20177738.001).
  • [ISSN] 1573-4919
  • [Journal-full-title] Molecular and cellular biochemistry
  • [ISO-abbreviation] Mol. Cell. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents, Phytogenic; 0 / Enzyme Inhibitors; 04079A1RDZ / Cytarabine; 6PLQ3CP4P3 / Etoposide; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; EC 2.7.12.2 / Mitogen-Activated Protein Kinase Kinases; EC 6.3.2.- / Proto-Oncogene Proteins c-cbl; EC 6.3.2.19 / Cblb protein, rat
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31. Castellani ML, Petrarca C, Frydas S, Conti CM, Salini V, Conti P, Shanmugham LN: Rat basophilic leukemia cells (RBL-2H3) generate prostaglandin D2 (PGD2) after regulated upon activation, normal T-cell expressed and secreted (RANTES) activation. Int J Biol Markers; 2006 Oct-Dec;21(4):211-7
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  • [Title] Rat basophilic leukemia cells (RBL-2H3) generate prostaglandin D2 (PGD2) after regulated upon activation, normal T-cell expressed and secreted (RANTES) activation.
  • [MeSH-major] Chemokine CCL5 / pharmacology. Leukemia, Basophilic, Acute / metabolism. Prostaglandin D2 / biosynthesis

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  • (PMID = 17177158.001).
  • [ISSN] 0393-6155
  • [Journal-full-title] The International journal of biological markers
  • [ISO-abbreviation] Int. J. Biol. Markers
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Chemokine CCL5; RXY07S6CZ2 / Prostaglandin D2; XXE1CET956 / Indomethacin
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32. Kaito K, Otsubo H, Dobashi N, Usui N, Kobayashi M: CD2+ tetraploid acute promyelocytic leukemia variant with double (15;17) translocations. Int J Hematol; 2005 Jan;81(1):29-31
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  • [Title] CD2+ tetraploid acute promyelocytic leukemia variant with double (15;17) translocations.
  • We report a patient with a variant form of CD2+ acute promyelocytic leukemia (APL) who had double translocations (15;17) in a single leukemic cell.
  • The bone marrow showed marked hyperplasia with large leukemic cells that had bizarre nuclear configuration and basophilic, hypogranular cytoplasm.
  • Fluorescence in situ hybridization assay revealed 2 promyelocytic leukemia and retinoic acid receptor alpha (PML/RARA) fusion signals, and reverse transcription-polymerase chain reaction assay revealed short-form PML/RARA fusion transcript.
  • Tetraploidy in APL is a very rare abnormality.
  • Double translocations were an additional abnormality in this case, and this patient's karyotype might have had some influence on morphological characteristics, expression of CD2, and poor clinical outcome.
  • [MeSH-major] Antigens, CD2 / genetics. Chromosomes, Human, Pair 15. Chromosomes, Human, Pair 17. Leukemia, Promyelocytic, Acute / genetics. Translocation, Genetic

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  • (PMID = 15717685.001).
  • [ISSN] 0925-5710
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD2
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33. Venizelos ID, Klonizakis I, Vlahaki E, Haralambidou S, Tatsiou Z, Ioannidou E: Skin relapse of acute myeloid leukemia associated with trisomy 8. Acta Dermatovenerol Alp Pannonica Adriat; 2007 Jun;16(2):77-80
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  • [Title] Skin relapse of acute myeloid leukemia associated with trisomy 8.
  • Acute myeloid leukemia (AML) is a morphologically diverse group of hematopoietic malignancies characterized by proliferation of immature cells that arise in the myeloid progenitor cells of the bone marrow.
  • A skin nodule from the right arm was excised and histology showed a diffuse infiltration of the dermis consisting of large cells with round to oval nuclei and little basophilic cytoplasm.
  • Accordingly, a diagnosis of AML involving the skin was made.
  • [MeSH-major] Chromosomes, Human, Pair 8. Leukemia, Myeloid, Acute / pathology. Skin Neoplasms / pathology. Trisomy

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  • (PMID = 17992463.001).
  • [ISSN] 1318-4458
  • [Journal-full-title] Acta dermatovenerologica Alpina, Pannonica, et Adriatica
  • [ISO-abbreviation] Acta Dermatovenerol Alp Pannonica Adriat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Slovenia
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34. Radaelli E, Marchesi F, Patton V, Scanziani E: Diagnostic exercise: sudden death in a mouse with experimentally induced acute myeloid leukemia. Vet Pathol; 2009 Nov;46(6):1301-5
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  • [Title] Diagnostic exercise: sudden death in a mouse with experimentally induced acute myeloid leukemia.
  • A 22-week-old female 129/SvEv mouse suddenly died in the context of an experiment aimed at defining the efficacy of valproic acid in a mouse model of PML/RARalpha-induced acute myeloid leukemia.
  • Histologic analysis confirmed the mouse as being affected by a progressive myeloid leukemia, with infiltration of the spleen, bone marrow, liver, kidneys, and lungs.
  • Variably sized intravascular clumps (emboli) of dense basophilic material admixed with necrotic or lytic neoplastic cells were also observed in multiple organs.
  • A positive reaction to Feulgen and Hoechst stain confirmed the high content in chromatin of these basophilic emboli.
  • Cleaved caspase-3 activity was demonstrated both in the leukemic infiltrates and among the intravascular necrotic or lytic neoplastic cells accompanying the basophilic emboli.
  • A diagnosis of acute tumor lysis syndrome related to therapy-induced massive necrosis and/or apoptosis of leukemic cells with subsequent dissemination of emboli of chromatin was proposed.
  • [MeSH-major] Leukemia, Myeloid, Acute / chemically induced. Tumor Lysis Syndrome / veterinary
  • [MeSH-minor] Acute Disease. Animals. Antineoplastic Agents / pharmacology. Death, Sudden. Disease Models, Animal. Female. Lung / pathology. Mice. Valproic Acid / pharmacology

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  • (PMID = 19605917.001).
  • [ISSN] 1544-2217
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 614OI1Z5WI / Valproic Acid
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35. Dreger SC, Schulz F, Huelsenbeck J, Gerhard R, Hofmann F, Just I, Genth H: Killing of rat basophilic leukemia cells by lethal toxin from Clostridium sordellii: critical role of phosphatidylinositide 3'-OH kinase/Akt signaling. Biochemistry; 2009 Mar 3;48(8):1785-92
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  • [Title] Killing of rat basophilic leukemia cells by lethal toxin from Clostridium sordellii: critical role of phosphatidylinositide 3'-OH kinase/Akt signaling.
  • [MeSH-major] Bacterial Toxins / toxicity. Leukemia, Basophilic, Acute / pathology. Phosphatidylinositol 3-Kinases / metabolism. Proto-Oncogene Proteins c-akt / metabolism. Signal Transduction / drug effects

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  • (PMID = 19199813.001).
  • [ISSN] 1520-4995
  • [Journal-full-title] Biochemistry
  • [ISO-abbreviation] Biochemistry
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Toxins; 0 / Clostridium difficile lethal toxin B; 0 / lethal toxin LT, Clostridium sordellii; 516-35-8 / Taurochenodeoxycholic Acid; 60EUX8MN5X / tauroursodeoxycholic acid; EC 2.4.- / Glycosyltransferases; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.4.22.- / Caspase 3
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36. Angulo J, Haro R, González-Guerra E, Fariña MC, Martín L, Requena L: Leukemia cutis presenting as localized cutaneous hyperpigmentation. J Cutan Pathol; 2008 Jul;35(7):662-5
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  • [Title] Leukemia cutis presenting as localized cutaneous hyperpigmentation.
  • The usual clinical presentations of leukemia cutis include solitary infiltrated erythematous or violaceous plaques or nodules and multiple localized or generalized papules.
  • On the other hand, cutaneous hyperpigmentation is a frequent finding in patients with malignancies, most of the cases because of chemotherapy or other drugs that the patient is taking.
  • We present a case of cutaneous hyperpigmentation as the presenting sign of leukemia cutis.
  • A 61-year-old male presented with cutaneous hyperpigmentation, which had appeared during the last chemotherapy cycle for treatment for biphenotypic leukemia.
  • This infiltrate was composed of atypical basophilic cells with large hyperchromatic nuclei and scant cytoplasm.
  • A diagnosis of biphenotypic leukemia cutis was established.
  • In our review of the literature we have not found any report of cutaneous hyperpigmentation as the presenting manifestation of leukemia cutis.
  • [MeSH-major] Hyperpigmentation / etiology. Leukemia, Biphenotypic, Acute / pathology. Skin / pathology. Skin Neoplasms / pathology

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  • (PMID = 18422694.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD
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37. Biedermann B, Gil D, Bowen DT, Crocker PR: Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors. Leuk Res; 2007 Feb;31(2):211-20
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  • [Title] Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors.
  • CD33 (Siglec-3) is expressed on most acute myeloid leukemia (AML) cells and is currently being exploited as a therapeutic target.
  • Using primary AML cells or transfected rat basophilic leukemia cells, Siglec-9 mediated rapid endocytosis of anti-Siglec-9 mAb.
  • [MeSH-major] Antigens, CD / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Hematopoietic Stem Cells / immunology. Lectins / analysis. Leukemia, Myeloid / immunology
  • [MeSH-minor] Acute Disease. Biomarkers, Tumor / analysis. Biomarkers, Tumor / biosynthesis. Flow Cytometry / methods. Humans. Sialic Acid Binding Ig-like Lectin 3. Sialic Acid Binding Immunoglobulin-like Lectins

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  • (PMID = 16828866.001).
  • [ISSN] 0145-2126
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CD33 protein, human; 0 / Lectins; 0 / SIGLEC5 protein, human; 0 / SIGLEC7 protein, human; 0 / SIGLEC9 protein, human; 0 / Sialic Acid Binding Ig-like Lectin 3; 0 / Sialic Acid Binding Immunoglobulin-like Lectins
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38. Chang ST, Hsieh YC, Lee LP, Tzeng CC, Chuang SS: Acute myelomonocytic leukemia with abnormal eosinophils: a case report with multi-modality diagnostic work-up. Chang Gung Med J; 2006 Sep-Oct;29(5):532-7
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  • [Title] Acute myelomonocytic leukemia with abnormal eosinophils: a case report with multi-modality diagnostic work-up.
  • Acute myeloid leukemia (AML) with recurrent genetic abnormalities often carries a favorable prognosis.
  • It is referred to as acute myelomonocytic leukemia with abnormal eosinophils (AMML Eo).
  • Marrow aspiration showed 47% blasts and 33% eosinophils, of which 19% were morphologically abnormal with both eosinophilic and basophilic cytoplasmic granules.
  • [MeSH-major] Eosinophils / pathology. Leukemia, Myelomonocytic, Acute / diagnosis

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  • (PMID = 17214400.001).
  • [ISSN] 2072-0939
  • [Journal-full-title] Chang Gung medical journal
  • [ISO-abbreviation] Chang Gung Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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39. Sun X, Zhang W, Ramdas L, Stivers DN, Jones DM, Kantarjian HM, Estey EH, Vadhan-Raj S, Medeiros LJ, Bueso-Ramos CE: Comparative analysis of genes regulated in acute myelomonocytic leukemia with and without inv(16)(p13q22) using microarray techniques, real-time PCR, immunohistochemistry, and flow cytometry immunophenotyping. Mod Pathol; 2007 Aug;20(8):811-20
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  • [Title] Comparative analysis of genes regulated in acute myelomonocytic leukemia with and without inv(16)(p13q22) using microarray techniques, real-time PCR, immunohistochemistry, and flow cytometry immunophenotyping.
  • Acute myeloid leukemia with inv(16)(p13q22), also known as M4Eo, is a distinct type of leukemia with characteristic clinicopathologic and cytogenetic features.
  • Patients with M4Eo have monocytosis, high blast counts, and abnormal bone marrow eosinophils that contain large basophilic granules.
  • Cases of acute myelomonocytic leukemia without CBFbeta-MYH11 (M4) acted as our control.
  • We found that in the gene expression profile of M4Eo, NF-kappaB activators and inhibitors were upregulated and downregulated, respectively, suggesting that the NF-kappaB signaling pathway is activated at a higher level in M4Eo than in acute myelomonocytic leukemia M4.
  • These findings most likely represent the functional consequences of the abnormal chimeric protein CBFbeta-MYH11, which is unique to this disease, and suggest that NF-kappaB is a potential therapeutic target for treating M4Eo patients.
  • [MeSH-major] Chromosomes, Human, Pair 16. Flow Cytometry. Gene Expression Profiling / methods. Immunohistochemistry. Immunophenotyping / methods. Leukemia, Myelomonocytic, Acute / genetics. Oligonucleotide Array Sequence Analysis. Polymerase Chain Reaction

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  • (PMID = 17571080.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 5P30 CA016672-28
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CBFbeta-MYH11 fusion protein; 0 / Oncogene Proteins, Fusion; 0 / Transcription Factor RelA
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40. Tsai MH, Yang CP, Chung HT, Shih LY: Acute myeloid leukemia in a young girl presenting with mediastinal granulocytic sarcoma invading pericardium and causing superior vena cava syndrome. J Pediatr Hematol Oncol; 2009 Dec;31(12):980-2
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  • [Title] Acute myeloid leukemia in a young girl presenting with mediastinal granulocytic sarcoma invading pericardium and causing superior vena cava syndrome.
  • A 1-year-4-month-old girl who presented with pericardial effusion and superior vena cava (SVC) syndrome caused by a mediastinal mass was later proved to be a case of acute myeloid leukemia (AML) with mixed-lineage leukemia-gene translocation.
  • The unusual presentation and the giant blasts with basophilic vacuolated cytoplasm had led to initial misdiagnosis of mediastinal lymphoma.
  • She developed progressive SVC syndrome, unresolved pericardial effusion, and extensive leukemia cutis after initial induction therapy.
  • To our knowledge, this is the first reported case of childhood acute myeloid leukemia presenting with mediastinal granulocytic sarcoma causing pericardium invasion and SVC syndrome.
  • [MeSH-major] Leukemia, Myeloid, Acute / pathology. Mediastinal Neoplasms / diagnosis. Pericardium / pathology. Sarcoma, Myeloid / diagnosis. Superior Vena Cava Syndrome / diagnosis
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Diagnosis, Differential. Fatal Outcome. Female. Humans. Infant. Pericardial Effusion / etiology


41. Braham Jmili N, Omri H, Senana Sendi H, Fekih S, Hizem S, Sriha B, Khelif A, Saad A, Kortas M: Identification of the translocation t(15;17) in acute myeloid leukemia (AML) initially classified as FAB M1: case report and review of the literature. Clin Lab; 2006;52(3-4):125-30
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  • [Title] Identification of the translocation t(15;17) in acute myeloid leukemia (AML) initially classified as FAB M1: case report and review of the literature.
  • The Wright-Giemsa stained bone marrow and peripheral blood smears showed a population of blast cells characterized by cells with high N/C and strongly basophilic cytoplasm without granules.
  • The diagnosis of acute myeloid leukaemia (AML) was then evoked initially.
  • From the biological findings the patient was retrospectively diagnosed as having promyelocytic leukemia (hyperbasophilic form).
  • [MeSH-major] Chromosomes, Human, Pair 15. Chromosomes, Human, Pair 17. Leukemia, Myeloid, Acute / genetics. Leukemia, Promyelocytic, Acute / genetics. Neoplasms, Second Primary / genetics. Translocation, Genetic


42. Rytting ME, Kantarjian H, Albitar M: Acute lymphoblastic leukemia with Burkitt-like morphologic features and high myeloperoxidase activity. Am J Clin Pathol; 2009 Aug;132(2):182-5; quiz 306
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  • [Title] Acute lymphoblastic leukemia with Burkitt-like morphologic features and high myeloperoxidase activity.
  • Expression of a high level of myeloperoxidase (MPO) as a sole myeloid marker in acute leukemias that express typical lymphoblastic markers is unusual.
  • Herein we report 5 cases of MPO+, otherwise typical acute lymphoblastic leukemia (ALL) without the expression of other myeloid markers.
  • The striking feature of most of these cases is a morphologic picture reminiscent of that seen in Burkitt-like B-cell ALL with basophilic cytoplasm and vacuoles but no expression of surface immunoglobulin.
  • All cases responded to ALL therapy and should be distinguished from myeloid leukemia and from Burkitt leukemia/lymphoma.
  • [MeSH-major] Biomarkers, Tumor / analysis. Peroxidase / metabolism. Precursor Cell Lymphoblastic Leukemia-Lymphoma / enzymology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology

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  • (PMID = 19605811.001).
  • [ISSN] 1943-7722
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 1.11.1.7 / Peroxidase
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43. Kawano-Yamamoto C, Muroi K, Nagatsuka Y, Higuchi M, Kikuchi S, Nagai T, Hakomori SI, Ozawa K: Establishment and characterization of a new erythroblastic leukemia cell line, EEB: phosphatidylglucoside-mediated erythroid differentiation and apoptosis. Leuk Res; 2006 Jul;30(7):829-39
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  • [Title] Establishment and characterization of a new erythroblastic leukemia cell line, EEB: phosphatidylglucoside-mediated erythroid differentiation and apoptosis.
  • A new erythroblastic leukemia cell line (EEB) was established from a patient with early erythroblastic leukemia.
  • The cells had features of immature erythroblasts, including an agranular basophilic cytoplasm and CD36, CD71, CD175s (sialyl-Tn) and CD235a (glycophorin A) expression without CD41 expression, myeloperoxidase activity and platelet-peroxidase activity.
  • [MeSH-major] Apoptosis / drug effects. Cell Line, Tumor. Erythroid Cells / drug effects. Glycerophospholipids / pharmacology. Immunoglobulin Fab Fragments / pharmacology. Leukemia, Erythroblastic, Acute / drug therapy. Leukemia, Erythroblastic, Acute / metabolism

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  • (PMID = 16332389.001).
  • [ISSN] 0145-2126
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / GL-7 Fab fragment; 0 / Glycerophospholipids; 0 / Immunoglobulin Fab Fragments; 0 / phosphatidylglucose; 42HK56048U / Tyrosine; 9004-22-2 / Globins
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44. Brink DS: Transient leukemia (transient myeloproliferative disorder, transient abnormal myelopoiesis) of Down syndrome. Adv Anat Pathol; 2006 Sep;13(5):256-62
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  • [Title] Transient leukemia (transient myeloproliferative disorder, transient abnormal myelopoiesis) of Down syndrome.
  • Transient leukemia of Down syndrome (DS-TL), also known as transient myeloproliferative disorder of Down syndrome (DS) and transient abnormal myelopoiesis of DS, occurs in approximately 10% of DS neonates and in phenotypically normal neonates with trisomy 21 mosaicism.
  • Bone marrow characteristics of DS-TL are, likewise, variable, though (in contrast to other leukemias) the bone marrow blast differential can be lower than the peripheral blood blast differential.
  • DS-TL neonates have a approximately 15% risk of developing potentially fatal liver disease and show <10% incidence of hydrops fetalis.
  • Despite its typical transient nature, 20% to 30% of DS-TL patients develop overt (nontransient) acute leukemia, usually within 3 years and typically of the M7 phenotype (acute megakaryoblastic leukemia).
  • The pathogenesis of DS-TL (and of subsequent acute leukemia) involves mutation of GATA1 (on chromosome X), which normally encodes a transcription factor integral to normal development of erythroid, megakaryocytic, and basophilic/mast cell lines.
  • [MeSH-minor] GATA1 Transcription Factor / genetics. Humans. Hydrops Fetalis / etiology. Infant, Newborn. Leukemia / etiology. Liver Diseases / etiology. Mutation

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  • (PMID = 16998319.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / GATA1 Transcription Factor; 0 / GATA1 protein, human
  • [Number-of-references] 81
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45. Wu Y, Slovak ML, Snyder DS, Arber DA: Coexistence of inversion 16 and the Philadelphia chromosome in acute and chronic myeloid leukemias : report of six cases and review of literature. Am J Clin Pathol; 2006 Feb;125(2):260-6
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  • [Title] Coexistence of inversion 16 and the Philadelphia chromosome in acute and chronic myeloid leukemias : report of six cases and review of literature.
  • We report 5 cases of chronic myelogenous leukemia (CML) and 1 case of acute myeloid leukemia (AML) with the dual presence of t(9;22) and inv(16).
  • The CBFbeta-MYH11 fusion gene was confirmed in all 3 CML cases and the 1 AML case tested, and this correlated with the presence of abnormal eosinophils with coarse basophilic granules.
  • [MeSH-major] Chromosome Inversion. Chromosomes, Human, Pair 16. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics. Leukemia, Myeloid, Acute / genetics. Philadelphia Chromosome

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  • (PMID = 16393682.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CBFB protein, human; 0 / Core Binding Factor beta Subunit; 0 / Recombinant Fusion Proteins; EC 3.6.4.1 / Myosin Heavy Chains
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46. Matsushima M, Takagi K, Ogawa M, Hirose E, Ota Y, Abe F, Baba K, Hasegawa T, Hasegawa Y, Kawabe T: Heme oxygenase-1 mediates the anti-allergic actions of quercetin in rodent mast cells. Inflamm Res; 2009 Oct;58(10):705-15
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  • OBJECTIVE AND DESIGN: We investigated the involvement of heme oxygenase (HO)-1 in the anti-allergic action of quercetin against degranulation of rat basophilic leukemia (RBL-2H3) cells, rat peritoneal mast cells, and mouse bone marrow-derived mast cells.
  • [MeSH-minor] Animals. Bilirubin / pharmacology. Carbon Monoxide / pharmacology. Cells, Cultured. Disease Models, Animal. Enzyme Inhibitors / pharmacology. Heme Oxygenase (Decyclizing) / metabolism. Leukemia, Basophilic, Acute / metabolism. Leukemia, Basophilic, Acute / pathology. Metalloporphyrins / pharmacology. Mice. Mice, Inbred BALB C. NF-E2-Related Factor 2 / metabolism. Protoporphyrins / pharmacology. Rats. Rats, Wistar

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  • (PMID = 19390785.001).
  • [ISSN] 1420-908X
  • [Journal-full-title] Inflammation research : official journal of the European Histamine Research Society ... [et al.]
  • [ISO-abbreviation] Inflamm. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Enzyme Inhibitors; 0 / Metalloporphyrins; 0 / NF-E2-Related Factor 2; 0 / Protoporphyrins; 14325-05-4 / tin protoporphyrin IX; 7U1EE4V452 / Carbon Monoxide; 9IKM0I5T1E / Quercetin; EC 1.14.99.3 / Heme Oxygenase (Decyclizing); EC 1.14.99.3 / Heme Oxygenase-1; EC 1.14.99.3 / heme oxygenase-2; RFM9X3LJ49 / Bilirubin
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47. Huang LS, Kim MR, Sok DE: Regulation of lipoxygenase activity by polyunsaturated lysophosphatidylcholines or their oxygenation derivatives. J Agric Food Chem; 2008 Sep 10;56(17):7808-14
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  • Likewise, arachidonoyl lysoPC and docosahexaenoyl lysoPC also inhibited 5-LOX activity from rat basophilic leukemia cells-2H3 (RBL-2H3) with IC50 values (50% inhibitory concentration) of 18.5 +/- 3.06 and 30.6 +/- 1.06 microM, respectively.
  • [MeSH-minor] Animals. Arachidonate 5-Lipoxygenase / metabolism. Cell Line, Tumor. Leukemia, Basophilic, Acute. Lipoxygenase Inhibitors / pharmacology. Rats. Solanum tuberosum / enzymology. Soybeans / enzymology

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  • (PMID = 18680379.001).
  • [ISSN] 1520-5118
  • [Journal-full-title] Journal of agricultural and food chemistry
  • [ISO-abbreviation] J. Agric. Food Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Lipoxygenase Inhibitors; 0 / Lysophosphatidylcholines; EC 1.13.11.12 / Lipoxygenase; EC 1.13.11.34 / Arachidonate 5-Lipoxygenase
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48. Ye N, Wang MW, Qin J, Lin B: Microfluidic devices for characterizing the agonist of formyl peptide receptor in RBL-FPR cells. Biomed Microdevices; 2010 Jun;12(3):513-21
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  • Finding of specific agonists and antagonists of FPR may provide potential therapeutic agents for FPR related disorders.
  • This work proposed a microfluidic-based method to characterize FPR-related cellular events in response to small peptides, N-formyl-Met-Leu-Phe (fMLF), in rat basophilic leukemia cell line RBL-2H3 expressing human FPR (RBL-FPR).
  • [MeSH-major] Drug Evaluation, Preclinical / instrumentation. Immunoassay / instrumentation. Leukemia, Basophilic, Acute / immunology. Microfluidic Analytical Techniques / instrumentation. Protein Interaction Mapping / instrumentation. Receptors, Formyl Peptide / drug effects. Receptors, Formyl Peptide / immunology

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  • (PMID = 20195765.001).
  • [ISSN] 1572-8781
  • [Journal-full-title] Biomedical microdevices
  • [ISO-abbreviation] Biomed Microdevices
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Formyl Peptide
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49. Fujimura Y, Yamada K, Tachibana H: A lipid raft-associated 67kDa laminin receptor mediates suppressive effect of epigallocatechin-3-O-gallate on FcepsilonRI expression. Biochem Biophys Res Commun; 2005 Oct 21;336(2):674-81
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  • Here we show that the 67LR is highly associated with lipid rafts on human basophilic KU812 cells.
  • [MeSH-major] Catechin / analogs & derivatives. Leukemia, Basophilic, Acute / metabolism. Membrane Microdomains / metabolism. Receptors, IgG / metabolism. Receptors, Laminin / metabolism

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  • (PMID = 16140266.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / FCGR1A protein, human; 0 / Receptors, IgG; 0 / Receptors, Laminin; 8R1V1STN48 / Catechin; BQM438CTEL / epigallocatechin gallate
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50. Ye YQ, Koshino H, Onose J, Negishi C, Yoshikawa K, Abe N, Takahashi S: Structural revision of thelephantin G by total synthesis and the inhibitory activity against TNF-alpha production. J Org Chem; 2009 Jun 19;74(12):4642-5
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  • Compound 2 strongly inhibited TNF (tumor necrosis factor)-alpha production in rat basophilic leukemia (RBL-2H3) cells: IC(50) = 3.5 nM, while a mixture of 1 and its regioisomer 15 showed no such activity.
  • [MeSH-minor] Animals. Cell Line, Tumor. Leukemia, Basophilic, Acute / metabolism. Nuclear Magnetic Resonance, Biomolecular. Rats. Stereoisomerism

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  • (PMID = 19453155.001).
  • [ISSN] 1520-6904
  • [Journal-full-title] The Journal of organic chemistry
  • [ISO-abbreviation] J. Org. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Terphenyl Compounds; 0 / Tumor Necrosis Factor-alpha
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51. Ishihara Y, Furuno T, Nakanishi M: The role of phosphatidylinositol 4-kinase type IIalpha in degranulation of RBL-2H3 cells. Inflamm Res; 2006 Nov;55(11):465-8
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  • OBJECTIVE AND DESIGN: We have studied the role of phosphatidylinositol 4-kinase IIalpha (PI4KIIalpha) in activation of rat basophilic leukemia (RBL-2H3) cells.
  • [MeSH-major] Calcium Signaling / physiology. Cell Degranulation / physiology. Leukemia, Basophilic, Acute / pathology. Leukemia, Basophilic, Acute / physiopathology. Phosphotransferases (Alcohol Group Acceptor) / physiology

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  • (PMID = 17122963.001).
  • [ISSN] 1023-3830
  • [Journal-full-title] Inflammation research : official journal of the European Histamine Research Society ... [et al.]
  • [ISO-abbreviation] Inflamm. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antigens; 0 / RNA, Messenger; 0 / Receptors, IgE; EC 2.7.1.- / Phosphotransferases (Alcohol Group Acceptor); EC 2.7.1.67 / phosphatidylinositol phosphate 4-kinase
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52. Chen HJ, Shih CK, Hsu HY, Chiang W: Mast cell-dependent allergic responses are inhibited by ethanolic extract of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) testa. J Agric Food Chem; 2010 Feb 24;58(4):2596-601
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  • The purpose of this study was to investigate the effects of adlay (Job's tears, Coix lachryma-jobi L. var. ma-yuen Stapf) testa against beta-hexosaminidase release as a marker of degranulation in rat basophilic leukemia (RBL)-2H3 cells.
  • [MeSH-minor] Acetophenones / pharmacology. Animals. Cell Line, Tumor / drug effects. Cell Line, Tumor / immunology. Coumaric Acids / pharmacology. Ethanol. Extracellular Signal-Regulated MAP Kinases / antagonists & inhibitors. Extracellular Signal-Regulated MAP Kinases / drug effects. Leukemia, Basophilic, Acute. Phosphorylation / drug effects. Rats. Signal Transduction / drug effects. Signal Transduction / physiology. beta-N-Acetylhexosaminidases / drug effects. beta-N-Acetylhexosaminidases / secretion

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  • (PMID = 20102206.001).
  • [ISSN] 1520-5118
  • [Journal-full-title] Journal of agricultural and food chemistry
  • [ISO-abbreviation] J. Agric. Food Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Acetophenones; 0 / Coumaric Acids; 0 / Plant Extracts; 3K9958V90M / Ethanol; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; EC 3.2.1.52 / beta-N-Acetylhexosaminidases; G1L3HT4CMH / 4-hydroxyacetophenone; IBS9D1EU3J / 4-coumaric acid
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53. Matsuda H, Nakamura S, Fujimoto K, Moriuchi R, Kimura Y, Ikoma N, Hata Y, Muraoka O, Yoshikawa M: Medicinal Flowers. XXXI. Acylated oleanane-type triterpene saponins, Sasanquasaponins I-V, with antiallergic activity from the flower buds of Camellia sasanqua. Chem Pharm Bull (Tokyo); 2010 Dec;58(12):1617-21
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  • The methanolic extract and its 1-butanol-soluble fraction from the flower buds of Camellia sasanqua THUNB. were found to show inhibitory activities on the release of β-hexosaminidase from rat basophile leukemia (RBL-2H3) cells.
  • [MeSH-minor] Animals. Cell Line, Tumor. Flowers / chemistry. Leukemia, Basophilic, Acute / metabolism. Magnetic Resonance Spectroscopy. Molecular Conformation. Rats. Structure-Activity Relationship. beta-N-Acetylhexosaminidases / metabolism

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  • (PMID = 21139265.001).
  • [ISSN] 1347-5223
  • [Journal-full-title] Chemical & pharmaceutical bulletin
  • [ISO-abbreviation] Chem. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Saponins; 0 / Triterpenes; 0 / oleanane; 6SMK8R7TGJ / Oleanolic Acid; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
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54. Nichols MG, Barth EE, Nichols JA: Reduction in DNA synthesis during two-photon microscopy of intrinsic reduced nicotinamide adenine dinucleotide fluorescence. Photochem Photobiol; 2005 Mar-Apr;81(2):259-69
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  • When imaging the punctate mitochondrial fluorescence originating from NAD(P)H in a rat basophilic leukemia (RBL) cell at low laser powers, no morphological changes are evident, and photobleaching is not observed when many images are taken.
  • [MeSH-major] DNA / biosynthesis. Leukemia, Basophilic, Acute / metabolism. Microscopy, Fluorescence, Multiphoton / methods. NADP / metabolism

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  • (PMID = 15647000.001).
  • [ISSN] 0031-8655
  • [Journal-full-title] Photochemistry and photobiology
  • [ISO-abbreviation] Photochem. Photobiol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / F32 CA 72225; United States / NCRR NIH HHS / RR / RR04224
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 53-59-8 / NADP; 9007-49-2 / DNA
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55. Zhu J, Wang O, Ruan L, Hou X, Cui Y, Wang JM, Le Y: The green tea polyphenol (-)-epigallocatechin-3-gallate inhibits leukocyte activation by bacterial formylpeptide through the receptor FPR. Int Immunopharmacol; 2009 Aug;9(9):1126-30
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  • Pretreatment of human monocytic cells or FPR-transfected rat basophilic leukemia cells (ETFR cells) with EGCG significantly inhibited fMLF-induced chemotaxis.
  • [MeSH-minor] Animals. Calcium-Calmodulin-Dependent Protein Kinases / antagonists & inhibitors. Camellia sinensis / immunology. Cell Line, Tumor. Cell Movement / drug effects. Cell Movement / immunology. Flavonoids / pharmacology. Humans. Inflammation. Injections, Intraperitoneal. Leukemia, Basophilic, Acute / blood. Leukemia, Basophilic, Acute / drug therapy. Leukemia, Basophilic, Acute / immunology. Mice. Rats. Receptors, Formyl Peptide / genetics. Receptors, Formyl Peptide / immunology. Receptors, Formyl Peptide / metabolism. Signal Transduction / drug effects. Signal Transduction / immunology. Transfection. Transgenes

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  • (PMID = 19426837.001).
  • [ISSN] 1878-1705
  • [Journal-full-title] International immunopharmacology
  • [ISO-abbreviation] Int. Immunopharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one; 0 / Antioxidants; 0 / Flavonoids; 0 / Receptors, Formyl Peptide; 59880-97-6 / N-Formylmethionine Leucyl-Phenylalanine; 8R1V1STN48 / Catechin; BQM438CTEL / epigallocatechin gallate; EC 2.7.11.17 / Calcium-Calmodulin-Dependent Protein Kinases
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56. Inoue T, Suzuki Y, Yoshimaru T, Ra C: Nitric oxide protects mast cells from activation-induced cell death: the role of the phosphatidylinositol-3 kinase-Akt-endothelial nitric oxide synthase pathway. J Leukoc Biol; 2008 May;83(5):1218-29
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  • [MeSH-minor] Animals. Cell Death. Cell Line, Tumor. Cell Survival. Leukemia, Basophilic, Acute. Mitochondria / pathology. Rats

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  • (PMID = 18285401.001).
  • [ISSN] 0741-5400
  • [Journal-full-title] Journal of leukocyte biology
  • [ISO-abbreviation] J. Leukoc. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 31C4KY9ESH / Nitric Oxide; EC 1.14.13.39 / Nitric Oxide Synthase Type III; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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57. Brock TG: Capturing proteins that bind polyunsaturated fatty acids: demonstration using arachidonic acid and eicosanoids. Lipids; 2008 Feb;43(2):161-9
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  • [MeSH-minor] Animals. Cell Line, Tumor. Electrophoresis, Gel, Two-Dimensional. Hydroxyeicosatetraenoic Acids / chemistry. Hydroxyeicosatetraenoic Acids / metabolism. Leukemia, Basophilic, Acute / metabolism. Rats

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  • (PMID = 18084788.001).
  • [ISSN] 0024-4201
  • [Journal-full-title] Lipids
  • [ISO-abbreviation] Lipids
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / R01 AI43574
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Eicosanoids; 0 / Fatty Acid-Binding Proteins; 0 / Fatty Acids, Unsaturated; 0 / Hydroxyeicosatetraenoic Acids; 27YG812J1I / Arachidonic Acid
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58. Nigro EA, Brini AT, Soprana E, Ambrosi A, Dombrowicz D, Siccardi AG, Vangelista L: Antitumor IgE adjuvanticity: key role of Fc epsilon RI. J Immunol; 2009 Oct 1;183(7):4530-6
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  • This finding suggests that the adjuvant effect of IgE could be exploited for human therapeutics.
  • [MeSH-minor] Adenocarcinoma / immunology. Adenocarcinoma / pathology. Adenocarcinoma / therapy. Animals. Antigens, Neoplasm / immunology. Cancer Vaccines / administration & dosage. Cancer Vaccines / genetics. Cancer Vaccines / immunology. Cell Line, Tumor. Cross-Linking Reagents / administration & dosage. Cross-Linking Reagents / metabolism. Cross-Linking Reagents / therapeutic use. Female. Gene Knock-In Techniques. Humans. Leukemia, Basophilic, Acute / immunology. Leukemia, Basophilic, Acute / pathology. Leukemia, Basophilic, Acute / therapy. Lymphoma, T-Cell / immunology. Lymphoma, T-Cell / pathology. Lymphoma, T-Cell / therapy. Mammary Neoplasms, Experimental / immunology. Mammary Neoplasms, Experimental / pathology. Mammary Neoplasms, Experimental / therapy. Mice. Mice, Inbred BALB C. Mice, Inbred C57BL. Mice, Knockout. Mice, Transgenic. Rats

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  • (PMID = 19748979.001).
  • [ISSN] 1550-6606
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Antigens, Neoplasm; 0 / Antineoplastic Agents; 0 / Cancer Vaccines; 0 / Cross-Linking Reagents; 0 / Receptors, IgE; 37341-29-0 / Immunoglobulin E
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59. Kanamaru Y, Tamouza H, Pfirsch S, El-Mehdi D, Guérin-Marchand C, Pretolani M, Blank U, Monteiro RC: IgA Fc receptor I signals apoptosis through the FcRgamma ITAM and affects tumor growth. Blood; 2007 Jan 1;109(1):203-11
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  • [MeSH-minor] Amino Acid Chloromethyl Ketones / pharmacology. Amino Acid Motifs. Animals. Caspase 3 / metabolism. Cell Line, Tumor. Cells, Cultured. Culture Media, Serum-Free. Cysteine Proteinase Inhibitors / pharmacology. Enzyme Activation. Female. Humans. Immunoglobulin A / immunology. Immunoglobulin Fab Fragments / pharmacology. Inflammation / immunology. Inflammation / pathology. Leukemia, Basophilic, Acute / pathology. Leukemia, Basophilic, Acute / therapy. Mast Cells / physiology. Mast Cells / transplantation. Mice. Mice, Inbred C57BL. Mice, Nude. Mice, Transgenic. Protein Tyrosine Phosphatase, Non-Receptor Type 6 / antagonists & inhibitors. Protein Tyrosine Phosphatase, Non-Receptor Type 6 / genetics. Protein Tyrosine Phosphatase, Non-Receptor Type 6 / physiology. RNA, Small Interfering / pharmacology. Rats. Receptors, IgG / physiology. Recombinant Fusion Proteins / physiology. Skin Transplantation. Transfection

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  • (PMID = 16990604.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amino Acid Chloromethyl Ketones; 0 / Antigens, CD; 0 / Culture Media, Serum-Free; 0 / Cysteine Proteinase Inhibitors; 0 / FCGR1A protein, human; 0 / Fc(alpha) receptor; 0 / Immunoglobulin A; 0 / Immunoglobulin Fab Fragments; 0 / RNA, Small Interfering; 0 / Receptors, Fc; 0 / Receptors, IgG; 0 / Recombinant Fusion Proteins; 0 / benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 6; EC 3.1.3.48 / Ptpn6 protein, rat; EC 3.4.22.- / Caspase 3
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60. Su Z, Guo X, Barker DS, Shoemaker RL, Marchase RB, Blalock JE: A store-operated nonselective cation channel in human lymphocytes. Cell Mol Neurobiol; 2005 Jun;25(3-4):625-47
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  • [MeSH-minor] Animals. Biological Transport / drug effects. Biological Transport / immunology. Calcium / metabolism. Cations / metabolism. Enzyme Inhibitors / pharmacology. Humans. Jurkat Cells. Leukemia, Basophilic, Acute. Membrane Potentials / drug effects. Membrane Potentials / immunology. Rats. Sodium / metabolism. TRPM Cation Channels. Thapsigargin / pharmacology. Transfection

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  • (PMID = 16075382.001).
  • [ISSN] 0272-4340
  • [Journal-full-title] Cellular and molecular neurobiology
  • [ISO-abbreviation] Cell. Mol. Neurobiol.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI37670; United States / NIDDK NIH HHS / DK / DK55647; United States / NHLBI NIH HHS / HL / HL68806
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cations; 0 / Enzyme Inhibitors; 0 / Ion Channels; 0 / Membrane Proteins; 0 / TRPM Cation Channels; 0 / TRPM2 protein, human; 67526-95-8 / Thapsigargin; 9NEZ333N27 / Sodium; SY7Q814VUP / Calcium
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61. Edwards BS, Young SM, Ivnitsky-Steele I, Ye RD, Prossnitz ER, Sklar LA: High-content screening: flow cytometry analysis. Methods Mol Biol; 2009;486:151-65
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  • [Title] High-content screening: flow cytometry analysis.
  • The HyperCyt high-throughput (HT) flow cytometry sampling platform uses a peristaltic pump, in combination with an autosampler, and a novel approach to data collection, to circumvent time-delay bottlenecks of conventional flow cytometry.
  • This approach also dramatically reduces the amount of sample aspirated for each analysis, typically requiring ~2 microL per sample while making quantitative fluorescence measurements of 40 or more samples per minute with thousands to tens of thousands of cells in each sample.
  • Here, we describe a simple robust screening assay that exploits the high-content measurement capabilities of the flow cytometer to simicroltaneously probe the binding of test compounds to two different receptors in a common assay volume, a duplex assay format.
  • The ability of the flow cytometer to distinguish cell-bound from free fluorophore is also exploited to eliminate wash steps during assay setup.
  • HT flow cytometry with this assay has allowed efficient screening of tens of thousands of small molecules from the NIH Small-Molecule Repository to identify selective ligands for two related G-protein-coupled receptors, the formylpeptide receptor and formylpeptide receptor-like 1.

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  • (PMID = 19347622.001).
  • [ISSN] 1064-3745
  • [Journal-full-title] Methods in molecular biology (Clifton, N.J.)
  • [ISO-abbreviation] Methods Mol. Biol.
  • [Language] ENG
  • [Grant] United States / NIMH NIH HHS / MH / R03 MH076381; United States / NIMH NIH HHS / MH / U54 MH074425; United States / NIMH NIH HHS / MH / R03 MH076381-01; United States / NIMH NIH HHS / MH / U54 MH074425-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / FPR2 protein, human; 0 / Ligands; 0 / Receptors, Formyl Peptide; 0 / Receptors, Lipoxin
  • [Other-IDs] NLM/ NIHMS650482; NLM/ PMC4476789
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62. Baik SY, Jung KH, Choi MR, Yang BH, Kim SH, Lee JS, Oh DY, Choi IG, Chung H, Chai YG: Fluoxetine-induced up-regulation of 14-3-3zeta and tryptophan hydroxylase levels in RBL-2H3 cells. Neurosci Lett; 2005 Feb 1;374(1):53-7
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  • [MeSH-major] 14-3-3 Proteins / metabolism. Fluoxetine / pharmacology. Leukemia, Basophilic, Acute / metabolism. Tryptophan Hydroxylase / metabolism

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  • (PMID = 15631896.001).
  • [ISSN] 0304-3940
  • [Journal-full-title] Neuroscience letters
  • [ISO-abbreviation] Neurosci. Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / 14-3-3 Proteins; 0 / Antidepressive Agents, Second-Generation; 01K63SUP8D / Fluoxetine; EC 1.14.16.4 / Tryptophan Hydroxylase
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63. Yamada P, Isoda H, Han JK, Talorete TP, Abe Y: Inhibitory effect of fulvic acid extracted from Canadian sphagnum peat on chemical mediator release by RBL-2H3 and KU812 cells. Biosci Biotechnol Biochem; 2007 May;71(5):1294-305
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  • To investigate the antiallergic effect of CP-FA, we incubated rat basophilic leukemia (RBL-2H3) cells with 0.001-10.0 microg/ml of CP-FA and determined the beta-hexosaminidase release inhibition at different response stages.
  • [MeSH-minor] Animals. Antigen-Antibody Complex / immunology. Antigens / immunology. Calcimycin / pharmacology. Calcium / analysis. Cell Line, Tumor. Dose-Response Relationship, Drug. Fluorescent Dyes. Formazans / metabolism. Humans. Immunoglobulin E / pharmacology. Ionophores / pharmacology. Leukemia, Basophilic, Acute. Leukemia, Experimental. Leukemia, Myelogenous, Chronic, BCR-ABL Positive. Nuclear Magnetic Resonance, Biomolecular. Rats. Spectroscopy, Fourier Transform Infrared. Tetradecanoylphorbol Acetate / pharmacology. Tetrazolium Salts / metabolism. beta-N-Acetylhexosaminidases / antagonists & inhibitors. p-Methoxy-N-methylphenethylamine / pharmacology

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  • [ErratumIn] Biosci Biotechnol Biochem. 2008 Oct;72(10):2008E4
  • (PMID = 17485833.001).
  • [ISSN] 0916-8451
  • [Journal-full-title] Bioscience, biotechnology, and biochemistry
  • [ISO-abbreviation] Biosci. Biotechnol. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Antigen-Antibody Complex; 0 / Antigens; 0 / Benzopyrans; 0 / Fluorescent Dyes; 0 / Formazans; 0 / Ionophores; 0 / Plant Extracts; 0 / Tetrazolium Salts; 23305-68-2 / MTT formazan; 37341-29-0 / Immunoglobulin E; 37H9VM9WZL / Calcimycin; 4091-50-3 / p-Methoxy-N-methylphenethylamine; EC 3.2.1.52 / beta-N-Acetylhexosaminidases; NI40JAQ945 / Tetradecanoylphorbol Acetate; SY7Q814VUP / Calcium; XII14C5FXV / fulvic acid
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64. Kaczocha M, Hermann A, Glaser ST, Bojesen IN, Deutsch DG: Anandamide uptake is consistent with rate-limited diffusion and is regulated by the degree of its hydrolysis by fatty acid amide hydrolase. J Biol Chem; 2006 Apr 7;281(14):9066-75
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  • The uptake of arachidonoyl ethanolamide (anandamide, AEA) in rat basophilic leukemia cells (RBL-2H3) has been proposed to occur via a saturable transporter that is blocked by specific inhibitors.
  • [MeSH-minor] Animals. Cell Culture Techniques. Cell Membrane. Diffusion. Endocannabinoids. Humans. Hydrolysis. Kinetics. Leukemia, Basophilic, Acute. Polyunsaturated Alkamides. Rats. Serum Albumin, Bovine

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  • (PMID = 16461355.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Grant] United States / NIDA NIH HHS / DA / DA16419; United States / NIDA NIH HHS / DA / DA9374
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Arachidonic Acids; 0 / Calcium Channel Blockers; 0 / Endocannabinoids; 0 / Polyunsaturated Alkamides; 0 / Serum Albumin, Bovine; 94421-68-8 / anandamide; EC 3.5.- / Amidohydrolases; EC 3.5.1.- / fatty-acid amide hydrolase
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65. Mazel T, Raymond R, Raymond-Stintz M, Jett S, Wilson BS: Stochastic modeling of calcium in 3D geometry. Biophys J; 2009 Mar 4;96(5):1691-706
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  • [Title] Stochastic modeling of calcium in 3D geometry.
  • Release of inflammatory mediators by mast cells in type 1 immediate-hypersensitivity allergic reactions relies on antigen-dependent increases in cytosolic calcium.
  • Here, we used a series of electron microscopy images to build a 3D reconstruction representing a slice through a rat tumor mast cell, which then served as a basis for stochastic modeling of inositol-trisphosphate-mediated calcium responses.
  • The stochastic approach was verified by reaction-diffusion modeling within the same geometry.
  • Local proximity of the endoplasmic reticulum to either the plasma membrane or mitochondria is predicted to differentially impact local inositol trisphosphate receptor transport.
  • The explicit consideration of organelle spatial relationships represents an important step toward building a comprehensive, realistic model of cellular calcium dynamics.

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  • (PMID = 19254531.001).
  • [ISSN] 1542-0086
  • [Journal-full-title] Biophysical journal
  • [ISO-abbreviation] Biophys. J.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / R01 AI051575; United States / NIAID NIH HHS / AI / R01 AI051575-06A2; United States / FDA HHS / BM / P20 BM0066283
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Inositol 1,4,5-Trisphosphate Receptors; 0 / Inositol Phosphates; 0 / inositol trispyrophosphate; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ PMC2996128
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66. Kumada H, Mitsutake S, Inagaki Y, Mitsunaga S, Tsuchikawa H, Katsumura S, Igarashi Y: Kinetics of the ceramide kinase inhibitor K1, a suppressor of mast-cell activation. Biosci Biotechnol Biochem; 2007 Oct;71(10):2581-4
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  • [MeSH-minor] Animals. Calcimycin / pharmacology. Carbon Radioisotopes / metabolism. Cell Line, Tumor. Chromatography, Thin Layer. Dose-Response Relationship, Drug. Ionophores / pharmacology. Kinetics. Leukemia, Basophilic, Acute / enzymology. Molecular Structure. Rats

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  • (PMID = 17928690.001).
  • [ISSN] 0916-8451
  • [Journal-full-title] Bioscience, biotechnology, and biochemistry
  • [ISO-abbreviation] Biosci. Biotechnol. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Carbon Radioisotopes; 0 / Ionophores; 0 / Protein Kinase Inhibitors; 37H9VM9WZL / Calcimycin; EC 2.7.1.- / Phosphotransferases (Alcohol Group Acceptor); EC 2.7.1.138 / ceramide kinase
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67. Abdullaev IF, Bisaillon JM, Potier M, Gonzalez JC, Motiani RK, Trebak M: Stim1 and Orai1 mediate CRAC currents and store-operated calcium entry important for endothelial cell proliferation. Circ Res; 2008 Nov 21;103(11):1289-99
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  • Using a maneuver that amplifies currents in divalent-free bath solutions, we show that EC CRAC has similar characteristics to that recorded from rat basophilic leukemia cells, namely a similar time course of activation, sensitivity to 2-aminoethoxydiphenyl borate, and low concentrations of lanthanides, and large Na(+) currents displaying the typical depotentiation.
  • Ectopic expression of Stim1 in ECs increased their I(CRAC) to a size comparable to that in rat basophilic leukemia cells.

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  • (PMID = 18845811.001).
  • [ISSN] 1524-4571
  • [Journal-full-title] Circulation research
  • [ISO-abbreviation] Circ. Res.
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / K22ES014729; United States / NIEHS NIH HHS / ES / ES014729-02; United States / NIEHS NIH HHS / ES / ES014729-01; United States / NIEHS NIH HHS / ES / K22 ES014729; United States / NIEHS NIH HHS / ES / K22 ES014729-02; United States / NIEHS NIH HHS / ES / K22 ES014729-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium Channels; 0 / DNA Primers; 0 / Membrane Glycoproteins; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / ORAI1 protein, human; 0 / Orai1 protein, rat; 0 / RNA, Messenger; 0 / RNA, Small Interfering; 0 / STIM1 protein, human; 0 / Stim1 protein, rat; 0 / TRPC Cation Channels; 0 / transient receptor potential cation channel, subfamily C, member 1; 67526-95-8 / Thapsigargin; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ NIHMS85575; NLM/ PMC2682347
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68. Lenman A, Fowler CJ: Interaction of ligands for the peroxisome proliferator-activated receptor gamma with the endocannabinoid system. Br J Pharmacol; 2007 Aug;151(8):1343-51
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  • EXPERIMENTAL APPROACH: Fatty acid amide hydrolase activity was measured in rat brain homogenates, C6 glioma and RBL2H3 basophilic leukaemia cells.
  • [MeSH-minor] Animals. Brain / enzymology. Brain Neoplasms / enzymology. Brain Neoplasms / pathology. Cell Line, Tumor. Dose-Response Relationship, Drug. Drug Design. Glioma / enzymology. Glioma / pathology. Hydrogen-Ion Concentration. Leukemia, Basophilic, Acute / enzymology. Leukemia, Basophilic, Acute / pathology. Ligands. Male. Monoacylglycerol Lipases / drug effects. Monoacylglycerol Lipases / metabolism. Rats. Rats, Sprague-Dawley. Receptor, Cannabinoid, CB1 / drug effects. Receptor, Cannabinoid, CB1 / metabolism. Receptor, Cannabinoid, CB2 / drug effects. Receptor, Cannabinoid, CB2 / metabolism. Thiazolidinediones / administration & dosage. Thiazolidinediones / pharmacology

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  • (PMID = 17592505.001).
  • [ISSN] 0007-1188
  • [Journal-full-title] British journal of pharmacology
  • [ISO-abbreviation] Br. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Cannabinoid Receptor Modulators; 0 / Endocannabinoids; 0 / Ligands; 0 / PPAR gamma; 0 / Receptor, Cannabinoid, CB1; 0 / Receptor, Cannabinoid, CB2; 0 / Thiazolidinediones; 74772-77-3 / ciglitazone; EC 3.1.1.23 / Monoacylglycerol Lipases; EC 3.5.- / Amidohydrolases; EC 3.5.1.- / fatty-acid amide hydrolase
  • [Other-IDs] NLM/ PMC2189817
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69. Mizota K, Yoshida A, Uchida H, Fujita R, Ueda H: Novel type of Gq/11 protein-coupled neurosteroid receptor sensitive to endocrine disrupting chemicals in mast cell line (RBL-2H3). Br J Pharmacol; 2005 Jun;145(4):545-50
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  • [MeSH-minor] Animals. Behavior, Animal / drug effects. Binding, Competitive / drug effects. Cattle. Cell Line, Tumor. Cell Membrane / drug effects. Cell Membrane / metabolism. Dehydroepiandrosterone / pharmacology. Dehydroepiandrosterone Sulfate / pharmacology. Dose-Response Relationship, Drug. Estradiol / pharmacology. Estrenes / pharmacology. Fluorescein-5-isothiocyanate / chemistry. Leukemia, Basophilic, Acute / metabolism. Leukemia, Basophilic, Acute / pathology. Macrocyclic Compounds. Male. Mast Cells / drug effects. Mast Cells / metabolism. Mast Cells / pathology. Mice. Nociceptors / drug effects. Oligonucleotides, Antisense / pharmacology. Oxazoles / pharmacology. Pain / chemically induced. Pain / prevention & control. Pertussis Toxin / pharmacology. Phenols / pharmacology. Phosphodiesterase Inhibitors / pharmacology. Pregnenolone / chemistry. Pregnenolone / metabolism. Pregnenolone / pharmacology. Pyrrolidinones / pharmacology. Serum Albumin, Bovine / chemistry. Type C Phospholipases / antagonists & inhibitors. Type C Phospholipases / metabolism. beta-N-Acetylhexosaminidases / secretion

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  • (PMID = 15821754.001).
  • [ISSN] 0007-1188
  • [Journal-full-title] British journal of pharmacology
  • [ISO-abbreviation] Br. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Estrenes; 0 / Macrocyclic Compounds; 0 / Oligonucleotides, Antisense; 0 / Oxazoles; 0 / Phenols; 0 / Phosphodiesterase Inhibitors; 0 / Pyrrolidinones; 0 / Receptors, Steroid; 0 / Serum Albumin, Bovine; 0 / xestospongin A; 112648-68-7 / 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione; 25154-52-3 / nonylphenol; 459AG36T1B / Dehydroepiandrosterone; 4TI98Z838E / Estradiol; 57B09Q7FJR / Dehydroepiandrosterone Sulfate; 73R90F7MQ8 / Pregnenolone; EC 2.4.2.31 / Pertussis Toxin; EC 3.1.4.- / Type C Phospholipases; EC 3.2.1.52 / beta-N-Acetylhexosaminidases; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gi-Go; I223NX31W9 / Fluorescein-5-isothiocyanate
  • [Other-IDs] NLM/ PMC1576165
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70. Molteni R, Crespo CL, Feigelson S, Moser C, Fabbri M, Grabovsky V, Krombach F, Laudanna C, Alon R, Pardi R: Beta-arrestin 2 is required for the induction and strengthening of integrin-mediated leukocyte adhesion during CXCR2-driven extravasation. Blood; 2009 Jul 30;114(5):1073-82
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  • [MeSH-minor] Animals. Cell Adhesion / physiology. Cell Line, Tumor / drug effects. Cell Line, Tumor / metabolism. DNA, Complementary / genetics. Integrin alpha4beta1 / physiology. Keratinocytes / physiology. Leukemia, Basophilic, Acute / pathology. Male. Mice. Mice, Knockout. Myeloid Cells / metabolism. RNA, Small Interfering / pharmacology. Rats. Recombinant Fusion Proteins / physiology. Shear Strength. Vascular Cell Adhesion Molecule-1 / metabolism. Venules


71. King N, Helm R, Stanley JS, Vieths S, Lüttkopf D, Hatahet L, Sampson H, Pons L, Burks W, Bannon GA: Allergenic characteristics of a modified peanut allergen. Mol Nutr Food Res; 2005 Oct;49(10):963-71
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  • [MeSH-minor] 2S Albumins, Plant. Amino Acid Sequence. Animals. Antigens, Plant. Binding Sites. Cell Line, Tumor. DNA, Complementary. Epitopes / chemistry. Humans. Immunoglobulin E / blood. Immunoglobulin E / immunology. Leukemia, Basophilic, Acute. Lymphocyte Activation. Molecular Sequence Data. Mutagenesis, Site-Directed. Peanut Hypersensitivity / immunology. Polymerase Chain Reaction. Rats. Recombinant Proteins / immunology. T-Lymphocytes / immunology

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  • (PMID = 16189800.001).
  • [ISSN] 1613-4125
  • [Journal-full-title] Molecular nutrition & food research
  • [ISO-abbreviation] Mol Nutr Food Res
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / 5K24 AI 01666
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / 2S Albumins, Plant; 0 / Allergens; 0 / Antigens, Plant; 0 / Ara h 2 allergen, Arachis hypogaea; 0 / DNA, Complementary; 0 / Epitopes; 0 / Glycoproteins; 0 / Plant Proteins; 0 / Recombinant Proteins; 37341-29-0 / Immunoglobulin E
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72. Tefferi A, Elliott MA, Pardanani A: Atypical myeloproliferative disorders: diagnosis and management. Mayo Clin Proc; 2006 Apr;81(4):553-63
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  • [Title] Atypical myeloproliferative disorders: diagnosis and management.
  • The World Health Organization system for classification of tumors of the hematopoietic system divides myeloid disorders into acute myeloid leukemia and chronic myeloid disorders based on the presence or absence, respectively, of acute myeloid leukemia--defining morphological and cytogenetic features including the presence of 20% or more myeloblasts in either the bone marrow or the peripheral blood.
  • Classic MPD includes polycythemia vera, essential thrombocythemia, myelofibrosis with myeloid metaplasia, and chronic myeloid leukemia.
  • The current review focuses on the diagnosis and treatment of both molecularly defined and clinicopathologically assigned categories of atypical MPD: chronic myelomonocytic leukemia, juvenile myelomonocytic leukemia, chronic neutrophilic leukemia, chronic basophilic leukemia, chronic eosinophilic leukemia, idiopathic eosinophilia including hypereosinophilic syndrome, systemic mastocytosis, unclassified MPD, and eosinophilic/mast cell disorders associated with mutations of platelet-derived growth factor receptors alpha (PDGFRA) and beta (PDGFRB), FGFR1, and KIT.
  • [MeSH-minor] Biomarkers, Tumor / genetics. Bone Marrow / pathology. Diagnosis, Differential. Humans

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  • (PMID = 16610578.001).
  • [ISSN] 0025-6196
  • [Journal-full-title] Mayo Clinic proceedings
  • [ISO-abbreviation] Mayo Clin. Proc.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 173
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73. Yoshimaru T, Suzuki Y, Inoue T, Nishida S, Ra C: Extracellular superoxide released from mitochondria mediates mast cell death by advanced glycation end products. Biochim Biophys Acta; 2008 Dec;1783(12):2332-43
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  • [MeSH-minor] Advanced Glycosylation End Product-Specific Receptor. Animals. Bone Marrow / metabolism. Calcium / metabolism. Caspase 3 / metabolism. Caspase 7 / metabolism. Cells, Cultured. Cytochromes c / metabolism. Enzyme Activation / drug effects. Glycosylation. Humans. Leukemia, Basophilic, Acute / metabolism. Leukemia, Basophilic, Acute / pathology. Membrane Potential, Mitochondrial / drug effects. Mice. Mice, Inbred C3H. Mice, Inbred C57BL. Mitochondrial Membrane Transport Proteins / drug effects. RNA, Messenger / genetics. RNA, Messenger / metabolism. RNA, Small Interfering / pharmacology. Rats. Receptors, IgG / metabolism. Receptors, Immunologic / antagonists & inhibitors. Receptors, Immunologic / genetics. Receptors, Immunologic / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 18822320.001).
  • [ISSN] 0006-3002
  • [Journal-full-title] Biochimica et biophysica acta
  • [ISO-abbreviation] Biochim. Biophys. Acta
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Advanced Glycosylation End Product-Specific Receptor; 0 / FCGR1A protein, human; 0 / Fcgr1 protein, mouse; 0 / Glycosylation End Products, Advanced; 0 / Mitochondrial Membrane Transport Proteins; 0 / RNA, Messenger; 0 / RNA, Small Interfering; 0 / Receptors, IgG; 0 / Receptors, Immunologic; 0 / Serum Albumin; 0 / glycosylated serum albumin; 0 / mitochondrial permeability transition pore; 11062-77-4 / Superoxides; 9007-43-6 / Cytochromes c; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspase 7; SY7Q814VUP / Calcium
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74. Mitsutake S, Igarashi Y: Calmodulin is involved in the Ca2+-dependent activation of ceramide kinase as a calcium sensor. J Biol Chem; 2005 Dec 9;280(49):40436-41
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  • [MeSH-minor] Amino Acid Sequence. Animals. Binding Sites. CHO Cells. Calcimycin / pharmacology. Calcium Chloride / pharmacology. Cell Degranulation / physiology. Cell Line, Tumor. Ceramides / metabolism. Cricetinae. Cricetulus. Egtazic Acid / pharmacology. Enzyme Activation / drug effects. Gene Deletion. Immunosorbent Techniques. Leukemia, Basophilic, Acute. Mast Cells / physiology. Mice. Molecular Sequence Data. Mutagenesis. Mutagenesis, Site-Directed. Point Mutation. Rats. Sulfonamides / pharmacology. Transfection

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  • (PMID = 16203736.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calmodulin; 0 / Ceramides; 0 / Sulfonamides; 0 / ceramide 1-phosphate; 37H9VM9WZL / Calcimycin; 526U7A2651 / Egtazic Acid; 65595-90-6 / W 7; EC 2.7.1.- / Phosphotransferases (Alcohol Group Acceptor); EC 2.7.1.138 / ceramide kinase; M4I0D6VV5M / Calcium Chloride; SY7Q814VUP / Calcium
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75. Papapetrou EP, Korkola JE, Sadelain M: A genetic strategy for single and combinatorial analysis of miRNA function in mammalian hematopoietic stem cells. Stem Cells; 2010 Feb;28(2):287-96
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  • These chimeras showed abnormal patterns of erythroid differentiation primarily affecting the proerythroblast to basophilic erythroblast transition, coinciding with the stage where expression of the miRNA cluster is dramatically induced and posttranscriptional gene regulation becomes prominent.
  • [MeSH-minor] Animals. Erythropoiesis / genetics. Erythropoiesis / physiology. Flow Cytometry. Leukemia, Erythroblastic, Acute. Mice. Tumor Cells, Cultured

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  • (PMID = 19911427.001).
  • [ISSN] 1549-4918
  • [Journal-full-title] Stem cells (Dayton, Ohio)
  • [ISO-abbreviation] Stem Cells
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL 57612; United States / NCI NIH HHS / CA / P01 CA059350
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MicroRNAs
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76. Nunomura S, Kitanaka S, Ra C: 3-O-(2,3-dimethylbutanoyl)-13-O-decanoylingenol from Euphorbia kansui suppresses IgE-mediated mast cell activation. Biol Pharm Bull; 2006 Feb;29(2):286-90
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  • Aggregation of the high affinity receptor for IgE (FcepsilonRI) on mast cells by antigen and IgE complex induces release of chemical mediators, leading to acute allergic inflammation.
  • We recently found that 3-O-(2,3-dimethylbutanoyl)-13-O-decanoylingenol (DBDI), purified from the Euphorbia kansui L., inhibits degranulation in rat basophilic leukemia 2H3 cells upon aggregation of the FcepsilonRI.

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  • (PMID = 16462033.001).
  • [ISSN] 0918-6158
  • [Journal-full-title] Biological & pharmaceutical bulletin
  • [ISO-abbreviation] Biol. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / 3-O-(2,3-dimethylbutanoyl)-13-O-decanoylingenol; 0 / Diterpenes; 0 / Eicosanoids; 0 / Receptors, IgE; 37341-29-0 / Immunoglobulin E; EC 3.2.1.52 / beta-N-Acetylhexosaminidases; SY7Q814VUP / Calcium
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77. Takahashi K, Matsumoto C, Ra C: FHL3 negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF-1. Biochem J; 2005 Feb 15;386(Pt 1):191-200
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  • [MeSH-minor] Cell Line, Tumor. Cell Nucleus / chemistry. Chromatography, Gel. DNA, Complementary / genetics. Down-Regulation / drug effects. Down-Regulation / physiology. Genes, Reporter. Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology. Humans. Interleukin-3 / pharmacology. Introns / genetics. Kruppel-Like Transcription Factors. LIM Domain Proteins. Leukemia, Basophilic, Acute / pathology. Molecular Sequence Data. Multigene Family. Promoter Regions, Genetic / genetics. Protein Binding. Protein Interaction Mapping. Protein Structure, Tertiary. Protein Transport. Recombinant Fusion Proteins / physiology. Saccharomyces cerevisiae / metabolism. Transformation, Genetic. Two-Hybrid System Techniques. Zinc Fingers / genetics. Zinc Fingers / physiology

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  • (PMID = 15453830.001).
  • [ISSN] 1470-8728
  • [Journal-full-title] The Biochemical journal
  • [ISO-abbreviation] Biochem. J.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ AB158503
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / DNA-Binding Proteins; 0 / FHL3 protein, human; 0 / Interleukin-3; 0 / Intracellular Signaling Peptides and Proteins; 0 / Kruppel-Like Transcription Factors; 0 / LIM Domain Proteins; 0 / MS4A2 protein, human; 0 / MZF1 protein, human; 0 / Receptors, IgE; 0 / Recombinant Fusion Proteins; 0 / Repressor Proteins; 0 / Transcription Factors; 83869-56-1 / Granulocyte-Macrophage Colony-Stimulating Factor
  • [Other-IDs] NLM/ PMC1134781
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78. Hemmerling J, Nell S, Kipp A, Schumann S, Deubel S, Haack M, Brigelius-Flohé R: alpha-Tocopherol enhances degranulation in RBL-2H3 mast cells. Mol Nutr Food Res; 2010 May;54(5):652-60
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  • [MeSH-minor] Animals. Cathepsin D / drug effects. Cathepsin D / metabolism. Cathepsin D / secretion. Cell Degranulation / drug effects. Cell Line, Tumor. DNA Primers. Hypoxanthine Phosphoribosyltransferase / genetics. Kinetics. Leukemia, Basophilic, Acute / enzymology. Mast Cells / drug effects. Mast Cells / enzymology. Mast Cells / physiology. Mice. RNA, Messenger / drug effects. RNA, Messenger / genetics. RNA, Neoplasm / genetics. RNA, Neoplasm / isolation & purification. Rats. beta-N-Acetylhexosaminidases / drug effects. beta-N-Acetylhexosaminidases / metabolism

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  • (PMID = 20169586.001).
  • [ISSN] 1613-4133
  • [Journal-full-title] Molecular nutrition & food research
  • [ISO-abbreviation] Mol Nutr Food Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA Primers; 0 / RNA, Messenger; 0 / RNA, Neoplasm; EC 2.4.2.8 / Hypoxanthine Phosphoribosyltransferase; EC 3.2.1.52 / beta-N-Acetylhexosaminidases; EC 3.4.23.5 / Cathepsin D; H4N855PNZ1 / alpha-Tocopherol
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79. Zou Z, Schmaier AA, Cheng L, Mericko P, Dickeson SK, Stricker TP, Santoro SA, Kahn ML: Negative regulation of activated alpha-2 integrins during thrombopoiesis. Blood; 2009 Jun 18;113(25):6428-39
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  • [MeSH-minor] Animals. Antigens, CD29 / metabolism. Blood Cells / cytology. Bone Marrow Cells / cytology. Cell Adhesion. Cell Differentiation. Cell Line, Tumor. Cell Movement. Collagen / metabolism. Collagen / pharmacology. Hematopoietic Stem Cell Transplantation. Hematopoietic Stem Cells / cytology. Hematopoietic Stem Cells / metabolism. Leukemia, Basophilic, Acute / pathology. Liver / cytology. Liver / embryology. Mice. Mice, Inbred C57BL. Mice, Knockout. Platelet Membrane Glycoproteins / deficiency. Platelet Membrane Glycoproteins / genetics. Point Mutation. Protein Binding. Radiation Chimera. Rats. Recombinant Fusion Proteins / physiology

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  • [CommentIn] Blood. 2009 Jun 18;113(25):6271-3 [19541834.001]
  • (PMID = 19258597.001).
  • [ISSN] 1528-0020
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD29; 0 / Integrin alpha2; 0 / Platelet Membrane Glycoproteins; 0 / Recombinant Fusion Proteins; 0 / platelet membrane glycoprotein VI; 9007-34-5 / Collagen
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80. Zuccato E, Blott EJ, Holt O, Sigismund S, Shaw M, Bossi G, Griffiths GM: Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation. J Cell Sci; 2007 Jan 1;120(Pt 1):191-9
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  • [MeSH-minor] Amino Acid Sequence. Animals. Endosomes / metabolism. HeLa Cells. Humans. Jurkat Cells. Leukemia, Basophilic, Acute. Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / chemistry. Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / genetics. Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / metabolism. Molecular Sequence Data. Phosphorylation. Protein Structure, Tertiary. Proto-Oncogene Proteins / chemistry. Proto-Oncogene Proteins / genetics. Proto-Oncogene Proteins / metabolism. Proto-Oncogene Proteins c-fyn / chemistry. Proto-Oncogene Proteins c-fyn / genetics. Proto-Oncogene Proteins c-fyn / metabolism. Rats. Signal Transduction / physiology. src Homology Domains / physiology. src-Family Kinases / chemistry. src-Family Kinases / genetics. src-Family Kinases / metabolism

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  • (PMID = 17164290.001).
  • [ISSN] 0021-9533
  • [Journal-full-title] Journal of cell science
  • [ISO-abbreviation] J. Cell. Sci.
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Fas Ligand Protein; 0 / Proto-Oncogene Proteins; 0 / Ubiquitin; EC 2.7.10.2 / FYN protein, human; EC 2.7.10.2 / Lymphocyte Specific Protein Tyrosine Kinase p56(lck); EC 2.7.10.2 / Proto-Oncogene Proteins c-fyn; EC 2.7.10.2 / lyn protein-tyrosine kinase; EC 2.7.10.2 / proto-oncogene proteins c-fgr; EC 2.7.10.2 / src-Family Kinases
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81. Zhang J, Lu W, Li Y, Wu J, Zhang C: Anti-sense RNA inhibits the expression of synaptotagmin II in RBL-2H3 and enhances the exocytosis of lysosomes in RBL-2H3. J Huazhong Univ Sci Technolog Med Sci; 2005;25(2):117-20
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  • [MeSH-major] Exocytosis. Leukemia, Basophilic, Acute / metabolism. Lysosomes / metabolism. RNA, Antisense / pharmacology. Synaptotagmin II / biosynthesis

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  • (PMID = 16116949.001).
  • [ISSN] 1672-0733
  • [Journal-full-title] Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
  • [ISO-abbreviation] J. Huazhong Univ. Sci. Technol. Med. Sci.
  • [Language] eng
  • [Databank-accession-numbers] RefSeq/ NM/ 012665
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / RNA, Antisense; 0 / RNA, Messenger; 0 / Synaptotagmin II; EC 3.4.23.5 / Cathepsin D
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82. Moreau B, Straube S, Fisher RJ, Putney JW Jr, Parekh AB: Ca2+-calmodulin-dependent facilitation and Ca2+ inactivation of Ca2+ release-activated Ca2+ channels. J Biol Chem; 2005 Mar 11;280(10):8776-83
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  • [MeSH-minor] Animals. Biological Transport / drug effects. Calcium-Transporting ATPases / metabolism. Cell Line, Tumor. Cell Membrane / enzymology. Cell Membrane / physiology. Kinetics. Leukemia, Basophilic, Acute. Patch-Clamp Techniques. Rats. Thapsigargin / pharmacology

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  • (PMID = 15611075.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0200218
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium Channels; 0 / Calmodulin; 67526-95-8 / Thapsigargin; EC 3.6.3.8 / Calcium-Transporting ATPases; SY7Q814VUP / Calcium
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83. Gieras A, Focke-Tejkl M, Ball T, Verdino P, Hartl A, Thalhamer J, Valenta R: Molecular determinants of allergen-induced effector cell degranulation. J Allergy Clin Immunol; 2007 Feb;119(2):384-90
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  • METHODS: A hybridoma cell line producing a monoclonal IgE antibody against a Phl p 1-derived peptide, P1, was established by means of immunization of mice and used to sensitize rat basophil leukemia cells, which were exposed to P1 monomer, P1 dimer, and P1 polymer.
  • [MeSH-minor] Amino Acid Sequence. Animals. Antibodies, Monoclonal / immunology. Cell Line, Tumor. Epitopes. Leukemia, Basophilic, Acute / immunology. Molecular Sequence Data. Rats

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  • (PMID = 17291855.001).
  • [ISSN] 0091-6749
  • [Journal-full-title] The Journal of allergy and clinical immunology
  • [ISO-abbreviation] J. Allergy Clin. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Antibodies, Monoclonal; 0 / Epitopes; 0 / Plant Proteins; 160227-82-7 / PHLPI protein, Phleum pratense; 37341-29-0 / Immunoglobulin E
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84. Horny HP, Sotlar K, Stellmacher F, Krokowski M, Agis H, Schwartz LB, Valent P: The tryptase positive compact round cell infiltrate of the bone marrow (TROCI-BM): a novel histopathological finding requiring the application of lineage specific markers. J Clin Pathol; 2006 Mar;59(3):298-302
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  • [Title] The tryptase positive compact round cell infiltrate of the bone marrow (TROCI-BM): a novel histopathological finding requiring the application of lineage specific markers.
  • AIMS: Compact tryptase-positive round cell infiltrates of the bone marrow (TROCI-BM) are very rare histopathological findings and may pose challenging problems with regard to the cell type involved (either mast cells or basophilic granulocytes) and the exact diagnosis.
  • METHODS: A selected panel of immunohistochemical markers against mast cell and basophil related antigens, including CD25, CD34, CD117/Kit, and the 2D7 antigen (which is found only in basophilic granulocytes) on a total of 410 routinely processed bone marrow biopsy specimens (including 88 cases of systemic mastocytosis (SM), 20 cases of chronic myeloid leukaemia (CML), 92 cases of myeloid neoplasms other than CML, and 210 controls with normal/reactive bone marrows).
  • RESULTS: In total, 17 cases with TROCI-BM could be identified: 11 SM (including two cases of well-differentiated SM and two mast cell leukaemias; MCL), 2 myelomastocytic leukaemia (MML), 2 CML with excess of basophils (secondary basophilic leukaemia (CMLba)), and 2 tryptase positive acute myeloid leukaemia (AML).
  • [MeSH-major] Bone Marrow Cells / enzymology. Mastocytosis / diagnosis. Serine Endopeptidases / analysis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Basophils / chemistry. Biomarkers / analysis. Cell Lineage. Female. Humans. Immunohistochemistry / methods. Immunophenotyping. Leukemia, Mast-Cell / diagnosis. Male. Mast Cells / chemistry. Middle Aged. Point Mutation. Proto-Oncogene Proteins c-kit / genetics. Receptors, Interleukin-2 / analysis. Retrospective Studies. Tryptases

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  • (PMID = 16505282.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Receptors, Interleukin-2; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 3.4.21.- / Serine Endopeptidases; EC 3.4.21.59 / Tryptases
  • [Other-IDs] NLM/ PMC1860329
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85. Maruo T, Namikawa K, Kunihiro A, Lynch J, Shida T, Kishikawa S: Large granular lymphocytic leukaemia complicated with histiocytic sarcoma in a dog. J S Afr Vet Assoc; 2009 Dec;80(4):261-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Large granular lymphocytic leukaemia complicated with histiocytic sarcoma in a dog.
  • Seventy-two per cent (81360/ml) of the lymphocytes were found to be 12-17 microm in diameter, containing nuclei with mature clumped chromatin and abundant lightly basophilic cytoplasm with a variable number of fine azurophilic granules.
  • Based on these findings this case was diagnosed as LGL leukaemia.
  • Shortly after diagnosis, the dog developed sudden onset of central nervous system signs and died on day 270.
  • A common outcome of canine LGL is the development of acute blast crisis or lymphoma.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Histiocytic Sarcoma / veterinary. Leukemia, Large Granular Lymphocytic / veterinary

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  • (PMID = 20458870.001).
  • [ISSN] 1019-9128
  • [Journal-full-title] Journal of the South African Veterinary Association
  • [ISO-abbreviation] J S Afr Vet Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] South Africa
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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86. Quan W, Lee HJ, Kim CY, Noh CW, Um BH, Oak MH, Kim KM: Anti-allergic prenylated flavonoids from the roots of Sophora flavescens. Planta Med; 2008 Feb;74(2):168-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Animals. Cell Line, Tumor. Leukemia, Basophilic, Acute. Rats. beta-N-Acetylhexosaminidases / antagonists & inhibitors. beta-N-Acetylhexosaminidases / metabolism

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  • (PMID = 18219599.001).
  • [ISSN] 0032-0943
  • [Journal-full-title] Planta medica
  • [ISO-abbreviation] Planta Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Flavonoids; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
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87. Park YK, Lee JW, Ko YG, Hong S, Park SH: Lipid rafts are required for efficient signal transduction by CD1d. Biochem Biophys Res Commun; 2005 Feb 25;327(4):1143-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Animals. Cell Line. Down-Regulation. Immunity, Active / immunology. Killer Cells, Natural / immunology. Killer Cells, Natural / metabolism. Leukemia, Basophilic, Acute / metabolism. Ligands. Mice. Mice, Knockout. Rats

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  • (PMID = 15652515.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD1; 0 / Ligands
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88. Nag A, Monine MI, Blinov ML, Goldstein B: A detailed mathematical model predicts that serial engagement of IgE-Fc epsilon RI complexes can enhance Syk activation in mast cells. J Immunol; 2010 Sep 15;185(6):3268-76
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A detailed mathematical model predicts that serial engagement of IgE-Fc epsilon RI complexes can enhance Syk activation in mast cells.
  • The term serial engagement was introduced to describe the ability of a single peptide, bound to a MHC molecule, to sequentially interact with TCRs within the contact region between a T cell and an APC.
  • In addition to ligands on surfaces, soluble multivalent ligands can serially engage cell surface receptors with sites on the ligand, binding and dissociating from receptors many times before all ligand sites become free and the ligand leaves the surface.
  • To evaluate the role of serial engagement in Syk activation, we use a detailed mathematical model of the initial signaling cascade that is triggered when FcepsilonRI is aggregated on mast cells by multivalent Ags.
  • Although serial engagement is not required for mast cell signaling, it can influence the recruitment of Syk to the receptor and subsequent Syk phosphorylation.
  • Simulating the response of mast cells to ligands that serially engage receptors at different rates shows that increasing the rate of serial engagement by increasing the rate of dissociation of the ligand-receptor bond decreases Syk phosphorylation.
  • Increasing serial engagement by increasing the rate at which receptors are cross-linked (for example by increasing the forward rate constant for cross-linking or increasing the valence of the ligand) increases Syk phosphorylation.
  • When serial engagement enhances Syk phosphorylation, it does so by partially reversing the effects of kinetic proofreading.
  • Serial engagement rapidly returns receptors that have dissociated from aggregates to new aggregates before the receptors have fully returned to their basal state.

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  • (PMID = 20733205.001).
  • [ISSN] 1550-6606
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / GM035556-27; United States / NIGMS NIH HHS / GM / R37 GM035556-27; United States / NIGMS NIH HHS / GM / R37 GM035556; United States / NIGMS NIH HHS / GM / R01 GM076570; United States / NCRR NIH HHS / RR / U54 RR022232; United States / NIGMS NIH HHS / GM / R37-GM035556
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / FcepsilonRI protein, rat; 0 / Immunoglobulin Fragments; 0 / Intracellular Signaling Peptides and Proteins; 0 / Ligands; 0 / Receptors, IgE; 37341-29-0 / Immunoglobulin E; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Syk kinase
  • [Other-IDs] NLM/ NIHMS292275; NLM/ PMC3102320
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89. Takahashi Y, Yoneyama S, Yamamoto S, Shibahara T, Kadota K: Acute basophilic leukaemia in a calf. Vet Rec; 2006 May 20;158(20):702-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acute basophilic leukaemia in a calf.
  • [MeSH-major] Cattle Diseases / diagnosis. Leukemia, Basophilic, Acute / veterinary
  • [MeSH-minor] Animals. Animals, Newborn. Cattle. Cell Differentiation. Cell Nucleus / ultrastructure. Cytoplasm / ultrastructure. Cytoplasmic Granules / ultrastructure. Diagnosis, Differential. Fatal Outcome. Male. Rumen / cytology

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  • (PMID = 16714438.001).
  • [ISSN] 0042-4900
  • [Journal-full-title] The Veterinary record
  • [ISO-abbreviation] Vet. Rec.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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90. Staal-Viliare A, Latger-Cannard V, Didion J, Grégoire MJ, Lecompte T, Jonveaux P, Rio Y: CD203c /CD117-, an useful phenotype profile for acute basophilic leukaemia diagnosis in cases of undifferentiated blasts. Leuk Lymphoma; 2007 Feb;48(2):439-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CD203c /CD117-, an useful phenotype profile for acute basophilic leukaemia diagnosis in cases of undifferentiated blasts.
  • [MeSH-major] Blast Crisis / diagnosis. Leukemia, Basophilic, Acute / diagnosis. Phosphoric Diester Hydrolases / blood. Proto-Oncogene Proteins c-kit / blood. Pyrophosphatases / blood
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Immunophenotyping. Male. Phenotype

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  • (PMID = 17325915.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / ENPP3 protein, human; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 3.1.4.- / Phosphoric Diester Hydrolases; EC 3.6.1.- / Pyrophosphatases
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91. Grégoire MJ, Latger-Cannard V, Staal A, Bologna S, Leotard B, Rault JP, Béry-Dexheimer M, Jonveaux P: Identification of an acute basophilic leukaemia carrying a rare e6a2 BCR-ABL transcript. Acta Haematol; 2006;116(3):216-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Identification of an acute basophilic leukaemia carrying a rare e6a2 BCR-ABL transcript.
  • [MeSH-major] Fusion Proteins, bcr-abl / genetics. Leukemia, Basophilic, Acute / genetics

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  • (PMID = 17016044.001).
  • [ISSN] 0001-5792
  • [Journal-full-title] Acta haematologica
  • [ISO-abbreviation] Acta Haematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] EC 2.7.10.2 / Fusion Proteins, bcr-abl
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92. Shvidel L, Sigler E, Shtalrid M, Berrebi A, Resnitzky P: Hybrid eosinophilic-basophilic acute myeloid leukaemia diagnosed by electron microscopy. Br J Haematol; 2007 May;137(4):381-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hybrid eosinophilic-basophilic acute myeloid leukaemia diagnosed by electron microscopy.
  • [MeSH-major] Basophils / ultrastructure. Eosinophils / ultrastructure. Leukemia, Myeloid, Acute / pathology

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  • (PMID = 17456060.001).
  • [ISSN] 0007-1048
  • [Journal-full-title] British journal of haematology
  • [ISO-abbreviation] Br. J. Haematol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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93. Masamoto Y, Nannya Y, Arai S, Koike Y, Hangaishi A, Yatomi Y, Kurokawa M: Evidence for basophilic differentiation of acute promyelocytic leukaemia cells during arsenic trioxide therapy. Br J Haematol; 2009 Mar;144(5):798-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evidence for basophilic differentiation of acute promyelocytic leukaemia cells during arsenic trioxide therapy.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Arsenicals / therapeutic use. Basophils / pathology. Leukemia, Promyelocytic, Acute / pathology. Oxides / therapeutic use

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  • (PMID = 19036092.001).
  • [ISSN] 1365-2141
  • [Journal-full-title] British journal of haematology
  • [ISO-abbreviation] Br. J. Haematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Arsenicals; 0 / Oxides; S7V92P67HO / arsenic trioxide
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94. Passante E, Ehrhardt C, Sheridan H, Frankish N: In vitro inhibition of rat basophilic leukaemia mast cell (RBL-2H3) degranulation by novel indane compounds. Inflamm Res; 2008;57 Suppl 1:S15-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] In vitro inhibition of rat basophilic leukaemia mast cell (RBL-2H3) degranulation by novel indane compounds.
  • [MeSH-major] Cell Degranulation / drug effects. Histamine Release / drug effects. Indenes / pharmacology. Leukemia, Basophilic, Acute / immunology. Mast Cells / drug effects

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  • (PMID = 18345510.001).
  • [ISSN] 1023-3830
  • [Journal-full-title] Inflammation research : official journal of the European Histamine Research Society ... [et al.]
  • [ISO-abbreviation] Inflamm. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Histamine H1 Antagonists, Non-Sedating; 0 / Indenes; 7BA5G9Y06Q / Terfenadine; 9IKM0I5T1E / Quercetin; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
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