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1. Kazakov DV, Mikyskova I, Kutzner H, Simpson RH, Hes O, Mukensnabl P, Bouda J, Zamecnik M, Kinkor Z, Michal M: Hidradenoma papilliferum with oxyphilic metaplasia: a clinicopathological study of 18 cases, including detection of human papillomavirus. Am J Dermatopathol; 2005 Apr;27(2):102-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hidradenoma papilliferum with oxyphilic metaplasia: a clinicopathological study of 18 cases, including detection of human papillomavirus.
  • Reported here are 18 cases of hidradenoma papilliferum with oxyphilic metaplasia.
  • This finding could be likened to apocrine metaplasia, a term used in breast pathology.
  • Other histopathological findings observed in this series, analogous to benign breast disease, included sclerosing adenosis-like changes, atypical apocrine adenosis-like changes, changes corresponding to usual ductal epithelial hyperplasia, epitheliomatosis with a streaming growth pattern, lamprocyte-like changes, clear cell change of the myoepithelium, foamy histiocyte reaction, and stromal fibrosis.
  • Using 2 different PCR methods we identified HPV in 4 of 15 cases of hidradenoma with oxyphilic metaplasia.
  • In addition, HPV was detected in 3 of 16 conventional papillary hidradenomas used as a control group.
  • Our observations are consistent with previous publications noting similarities between tumors of the breast and sweat glands.
  • Oxyphilic metaplasia, areas with solid growth, and changes simulating atypical apocrine adenosis are rare and poorly recognized in hidradenoma papilliferum and may cause diagnostic difficulties; in our cases several submitting pathologists suspected malignancy.
  • A causal role for HPV in hidradenoma papilliferum cannot be confirmed from our results, as the detection rate is too low.
  • [MeSH-major] Adnexal Diseases / pathology. Metaplasia / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adenoma, Sweat Gland / pathology. Adult. Aged. Animals. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged. Papillomaviridae. Papillomavirus Infections / complications. Papillomavirus Infections / pathology. Polymerase Chain Reaction

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  • (PMID = 15798433.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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2. Durairaj VD, Bartlett HM, Said S: Malignant hidradenoma of the medial canthus with orbital and intracranial extension. Ophthal Plast Reconstr Surg; 2006 May-Jun;22(3):229-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant hidradenoma of the medial canthus with orbital and intracranial extension.
  • A 70-year-old woman presented with signs and symptoms consistent with nasolacrimal duct obstruction.
  • A diagnosis of malignant hidradenoma of the medial canthus was confirmed by histopathology.
  • Despite aggressive therapy, the patient developed metastatic disease and died within 1 year.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Brain Neoplasms / secondary. Eyelid Neoplasms / pathology. Orbital Neoplasms / secondary. Paranasal Sinus Neoplasms / secondary

  • MedlinePlus Health Information. consumer health - Brain Tumors.
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  • (PMID = 16714943.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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