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36. Ansari NA: Malignant eccrine poroma. Saudi Med J; 2005 Oct;26(10):1665; author reply 1665
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  • [Title] Malignant eccrine poroma.
  • [MeSH-major] Acrospiroma / pathology. Cell Transformation, Neoplastic / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • [CommentOn] Saudi Med J. 2005 May;26(5):859-61 [15951884.001]
  • (PMID = 16228085.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] Saudi Arabia
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37. de Bree E, Volalakis E, Tsetis D, Varthalitis Y, Panagiotidis J, Romanos J, Tsiftsis DD: Treatment of advanced malignant eccrine poroma with locoregional chemotherapy. Br J Dermatol; 2005 May;152(5):1051-5
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  • [Title] Treatment of advanced malignant eccrine poroma with locoregional chemotherapy.
  • Malignant eccrine poroma is a rare disease with approximately 200 cases reported in the literature.
  • We report on a case in which topical 5-fluorouracil application and intra-arterial chemotherapy with docetaxel resulted in a histologically confirmed complete response of multiple regional skin metastases for more than 2 years.
  • Despite intravenous administration of docetaxel, slow progression of systemic disease was observed.
  • [MeSH-major] Acrospiroma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Sweat Gland Neoplasms / drug therapy
  • [MeSH-minor] Aged. Disease Progression. Fluorouracil / administration & dosage. Humans. Leg. Male. Skin Neoplasms / drug therapy. Skin Neoplasms / pathology. Skin Neoplasms / secondary. Taxoids / administration & dosage

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  • (PMID = 15888170.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Taxoids; 15H5577CQD / docetaxel; U3P01618RT / Fluorouracil
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38. Jariwala A, Evans A, McLeod G: Not all stubbed toes are innocuous--A case report of rare malignant eccrine spiradenoma (spiradenocarcinoma) of the toe. Foot Ankle Surg; 2010 Jun;16(2):e32-3
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  • [Title] Not all stubbed toes are innocuous--A case report of rare malignant eccrine spiradenoma (spiradenocarcinoma) of the toe.
  • Malignant eccrine spiradenoma (MES) is a rare adnexal tumour derived from cutaneous sweat glands.
  • [MeSH-major] Acrospiroma / diagnosis. Sweat Gland Neoplasms / diagnosis. Toes

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  • [Copyright] Copyright 2009 European Foot and Ankle Society. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20483125.001).
  • [ISSN] 1460-9584
  • [Journal-full-title] Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons
  • [ISO-abbreviation] Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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39. Canedo T, de Almeida MP, Cuzzi T, Ramos-e-Silva M: Immunophenotypic aspects of cylindroma and nodular hidradenoma. J Eur Acad Dermatol Venereol; 2010 Feb;24(2):178-85
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  • [Title] Immunophenotypic aspects of cylindroma and nodular hidradenoma.
  • OBJECTIVES: To evaluate the eccrine and/or apocrine differentiation phenotype in cases of cylindroma and clear cell hidradenoma with CD15 and p63 antibodies.
  • METHODOLOGY: Slides and blocks of six cases of cylindroma and seven cases of nodular hidradenoma (clear cells) were analyzed by the technique of immunohistochemistry with CD15 and p63 antibodies.
  • In five of seven cases of nodular hidradenoma (clear cell), we could easily observe clear cells between 20% and 50% of tumour cells.
  • In the two other cases, cystic lesions were present and occasional clear cells could be seen.
  • The reaction with CD15 antibody was positive in granular and cytoplasmic pattern in six of seven cases, especially in cells with suggestive clear cytoplasm in lower proportion than this clear cells could be seen in haematoxylin and eosin.
  • CONCLUSIONS: The present study suggests eccrine origin for both tumours: cylindroma and clear cell hidradenoma.
  • [MeSH-major] Acrospiroma / immunology. Carcinoma, Adenoid Cystic / immunology. Immunophenotyping
  • [MeSH-minor] Antigens, CD15 / immunology. Cell Differentiation. Humans. Immunohistochemistry. Membrane Proteins / immunology

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  • (PMID = 19796089.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, CD15; 0 / CKAP4 protein, human; 0 / Membrane Proteins
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40. Joshi RR, Nepal A, Ghimire A, Karki S: Eccrine poroma in neck of a child--a rare presentation. Nepal Med Coll J; 2009 Mar;11(1):73-4
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  • [Title] Eccrine poroma in neck of a child--a rare presentation.
  • An eccrine poroma is a common benign tumour arising from the eccrine sweat gland duct epithelium in the dermo-epidermal region.
  • Here we report a case of an eccrine poroma in the retro-auricular area just below and behind the lobule of the left pinna in a nine years old child.
  • [MeSH-major] Acrospiroma / diagnosis. Head and Neck Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 19769246.001).
  • [Journal-full-title] Nepal Medical College journal : NMCJ
  • [ISO-abbreviation] Nepal Med Coll J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nepal
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41. Lee SY, Hwang SS, Kim HJ, Jung JH: Eccrine acrospiroma of inguinal area: Computed tomography findings. J Comput Assist Tomogr; 2006 Mar-Apr;30(2):223-5
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  • [Title] Eccrine acrospiroma of inguinal area: Computed tomography findings.
  • Eccrine acrospiroma is a tumor originating from the sweat glands.
  • The computed tomography findings of eccrine acrospiroma in the right inguinal area are presented.
  • In our case, the tumor was seen as a well-defined and ovoid-shaped cystic mass with an internal enhancing solid portion and containing calcifications.
  • Eccrine acrospiroma should be considered in the differential diagnosis of a subcutaneous cystic mass with an internal solid nodule.
  • [MeSH-major] Acrospiroma / radiography. Sweat Gland Neoplasms / radiography. Tomography, X-Ray Computed

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  • (PMID = 16628036.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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42. Zhai Z, Yang X, Hao F, Ye Q, Zhong B: Multiple eccrine spiradenomas in a linear or zosteriform distribution involving the right side of the body. Int J Dermatol; 2008 Nov;47(11):1165-7
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  • [Title] Multiple eccrine spiradenomas in a linear or zosteriform distribution involving the right side of the body.
  • [MeSH-major] Acrospiroma / pathology. Neoplasms, Multiple Primary / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18986452.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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43. Goh SG, Dayrit JF, Calonje E: Sarcomatoid eccrine porocarcinoma: report of two cases and a review of the literature. J Cutan Pathol; 2007 Jan;34(1):55-60
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  • [Title] Sarcomatoid eccrine porocarcinoma: report of two cases and a review of the literature.
  • Eccrine porocarcinoma is an uncommon sweat gland malignancy.
  • We present two cases of sarcomatoid eccrine porocarcinoma associated with a benign poroma.
  • Case 1 pertained to an 82-year-old woman with an ulcerated chest wall tumor, and Case 2 was that of a 74-year-old woman who presented with an ulcerated plaque in the lower leg.
  • Case 1 showed an unusual pseudo-angiosarcomatous morphology with spindle cells dissecting through collagen bundles and forming vascular like channels.
  • In both the cases, benign poromatous elements were histologically evident.
  • [MeSH-major] Acrospiroma / pathology. Leg. Sweat Gland Neoplasms / pathology. Thoracic Wall

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  • (PMID = 17214856.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Actins; 0 / Carcinoembryonic Antigen; 0 / Mucin-1; 68238-35-7 / Keratins
  • [Number-of-references] 31
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4. Ben Brahim E, Sfia M, Tangour M, Makhlouf R, Cribier B, Chatti S: Malignant eccrine spiradenoma: a new case report. J Cutan Pathol; 2010 Apr;37(4):478-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant eccrine spiradenoma: a new case report.
  • Malignant eccrine spiradenoma is an extremely rare skin tumor of sweat gland origin.
  • In most cases, it arises in pre-existing benign eccrine spiradenoma.
  • We report an additional case of malignant eccrine spiradenoma.
  • The present case is of a 75-year-old man with malignant eccrine spiradenoma developed in the right shoulder.
  • He had a 6-year history of a recurrent mass that was removed 2 years ago.
  • Microscopically, there were two distinct morphological components: a benign eccrine spiradenoma and a malignant eccrine spiradenoma of low grade with extensive necrosis.
  • Morphological differentiation in malignant eccrine spiradenoma is variable, sometimes with almost complete loss of eccrine differentiation.
  • Extensive sampling to look for a probable previously benign component is necessary.
  • [MeSH-major] Acrospiroma / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19614990.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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45. Gatti A, di Meo N, Trevisan G: Dermoscopy of eccrine acrospiroma masquerading as nodular malignant melanoma. Acta Dermatovenerol Alp Pannonica Adriat; 2010 Dec;19(4):23-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dermoscopy of eccrine acrospiroma masquerading as nodular malignant melanoma.
  • Eccrine acrospiroma, better known as eccrine poroma, is a benign adnexal neoplasm of the skin.
  • Its clinical aspect can masquerade as some other nodular and cystic lesions.
  • Its homogeneous blue pattern suggested the better-known nodular malignant melanoma; in fact, this dermoscopic appearance was due to the Tyndall effect.
  • [MeSH-major] Acrospiroma / pathology. Dermoscopy. Melanoma / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology


46. Gerber PA, Bruch-Gerharz D, Schulte KW, Ruzicka T, Megahed M: [Eccrine porocarcinoma of the head. Report 3 cases]. Hautarzt; 2005 Apr;56(4):366-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Eccrine porocarcinoma of the head. Report 3 cases].
  • [Transliterated title] Ekkrines Porokarzinom des Kopfes. Bericht von 3 Fällen.
  • [MeSH-major] Acrospiroma / pathology. Acrospiroma / surgery. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / surgery. Sweat Gland Neoplasms / pathology. Sweat Gland Neoplasms / surgery

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  • [Cites] J Am Acad Dermatol. 1992 Aug;27(2 Pt 2):306-11 [1325487.001]
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  • (PMID = 15750674.001).
  • [ISSN] 0017-8470
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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47. Navi D, Fung M, Lynch PJ: Poromatosis: the occurrence of multiple eccrine poromas. Dermatol Online J; 2008;14(1):3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Poromatosis: the occurrence of multiple eccrine poromas.
  • Eccrine poromas are rare, benign adnexal tumors derived from the intraepidermal portion of sweat ducts.
  • Historically they were thought to arise from eccrine ducts although today it is thought that they may also have an apocrine origin.
  • They usually appear as solitary, slow-growing, skin-colored papules on acral surfaces.
  • Here we present the unusual situation of a patient with multiple poromas only three of which are located near the distal extremities.
  • [MeSH-major] Acrospiroma / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18319020.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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48. Tanese K, Sato T, Ishiko A: Malignant eccrine spiradenoma: case report and review of the literature, including 15 Japanese cases. Clin Exp Dermatol; 2010 Jan;35(1):51-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant eccrine spiradenoma: case report and review of the literature, including 15 Japanese cases.
  • Malignant eccrine spiradenoma (MES) is an extremely rare cutaneous malignant tumour.
  • An excisional biopsy was taken and histological examination showed a solid island of cells of two distinct types: cells with abundant cytoplasm and oval vesicular nuclei, and small round cells with less cytoplasm and hyperchromatic nuclei with a high frequency of mitosis.
  • We reviewed cases of malignant eccrine spiradenoma in the English and Japanese literature and found that 'sarcomatous' or 'squamous' change in histopathology was significantly correlated with a poorer prognosis.
  • [MeSH-major] Acrospiroma / pathology. Hand. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology


49. Chen SY, Takeuchi S, Urabe K, Kido M, Hayashida S, Tomoeda H, Uchi H, Dainichi T, Takahara M, Shibata S, Furue M, Moroi Y, Tu YT: Overexpression of phosphorylated ATF2 and STAT3 in eccrine porocarcinoma and eccrine poroma. J Dermatol Sci; 2008 Feb;49(2):170-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Overexpression of phosphorylated ATF2 and STAT3 in eccrine porocarcinoma and eccrine poroma.
  • [MeSH-major] Acrospiroma / chemistry. Activating Transcription Factor 2 / analysis. Adenocarcinoma / chemistry. Eccrine Glands / chemistry. Keratinocytes / chemistry. STAT3 Transcription Factor / analysis. Sweat Gland Neoplasms / chemistry
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Nucleus / chemistry. Female. Humans. Male. Middle Aged. Phosphorylation. Up-Regulation

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  • (PMID = 17869487.001).
  • [ISSN] 0923-1811
  • [Journal-full-title] Journal of dermatological science
  • [ISO-abbreviation] J. Dermatol. Sci.
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / ATF2 protein, human; 0 / Activating Transcription Factor 2; 0 / STAT3 Transcription Factor; 0 / STAT3 protein, human
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50. Gangane N, Joshi D, Sharma SM: Cytomorphological diagnosis of malignant eccrine tumors: report of two cases. Diagn Cytopathol; 2008 Nov;36(11):801-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytomorphological diagnosis of malignant eccrine tumors: report of two cases.
  • We hereby describe the cytological features of two histologically confirmed cases of malignant eccrine tumors.
  • Case number 1 presented with an ulcerated infraclavicular swelling whereas case number 2 presented with a cystic swelling over left foot.
  • A cytological diagnosis of low grade papillary adenocarcinoma arising from skin adnexal structures was given in case number 1.
  • Histological examination revealed the presence of malignant eccrine acrospiroma in case number 1 and papillary digital adenocarcinoma in case number 2.
  • Careful cytological examination displayed the characteristic of two cell population seen in eccrine tumors in both the cases.
  • Diagnosis of malignant eccrine tumors cannot be made with certainity on cytology alone, hence the need to document the cytological features of these entities is emphasized.
  • [MeSH-major] Sweat Gland Neoplasms / diagnosis. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Cell Aggregation. Cell Nucleus / pathology. Female. Humans. Male. Middle Aged

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  • (PMID = 18831018.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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51. Nicolino R, Zalaudek I, Ferrara G, Annese P, Giorgio CM, Moscarella E, Sgambato A, Argenziano G: Dermoscopy of eccrine poroma. Dermatology; 2007;215(2):160-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dermoscopy of eccrine poroma.
  • Eccrine poroma (EP) may clinically mimic a number of benign and malignant skin tumors.
  • Dermoscopy improves the clinical diagnosis of many pigmented and nonpigmented skin tumors, but to date little is known about the impact of dermoscopy in the diagnosis of EP.
  • [MeSH-major] Acrospiroma / pathology. Dermoscopy. Skin / pathology. Sweat Gland Neoplasms / pathology

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  • [Copyright] Copyright (c) 2007 S. Karger AG, Basel.
  • (PMID = 17684381.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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52. Chiu HH, Chen PH, Wu CS, Chen GS, Tsai KB, Wen CH, Lan CC: Origin of poroid hidradenoma and pigmentation mechanism of eccrine poroma: critical analysis of an unique presentation. J Eur Acad Dermatol Venereol; 2009 May;23(5):597-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Origin of poroid hidradenoma and pigmentation mechanism of eccrine poroma: critical analysis of an unique presentation.
  • [MeSH-major] Adenoma, Sweat Gland / etiology. Eccrine Glands / pathology. Skin Pigmentation

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  • (PMID = 18783473.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Endothelin-1
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53. Affleck AG, Bong JL, Ostroumova MA, Leach IH, Perks AG, Varma S: Eccrine porocarcinoma. Dermatol Online J; 2006;12(1):17
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eccrine porocarcinoma.
  • We present an unusual case of eccrine porocarcinoma in that diagnosis was delayed for many years after the initial lesion appeared, resulting in relatively large tumor.
  • [MeSH-major] Acrospiroma / pathology. Leg. Sweat Gland Neoplasms / pathology

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  • (PMID = 16638385.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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54. Asghar AH, Mahmood H, Faheem M, Rizvi S, Khan KA, Irfan J: Porocarcinoma: a rare sweat gland malignancy. J Coll Physicians Surg Pak; 2009 Jun;19(6):389-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Porocarcinoma: a rare sweat gland malignancy.
  • Eccrine Porocarcinoma (ECP) is a malignant tumour arising from the intraepithelial ductal parts of the sweat gland.
  • It has also been described as malignant hidroacanthoma simplex, sweat gland carcinoma, malignant intra-epidermal eccrine poroma, eccrine poroepithelioma, dysplastic poroma, malignant syringo acanthoma and porocarcinoma.
  • [MeSH-major] Acrospiroma / diagnosis
  • [MeSH-minor] Antibiotics, Antineoplastic / therapeutic use. Antineoplastic Agents / therapeutic use. Cisplatin / therapeutic use. Doxorubicin / therapeutic use. Humans. Male. Middle Aged. Sweat Gland Neoplasms / diagnosis. Sweat Gland Neoplasms / drug therapy. Sweat Gland Neoplasms / surgery

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  • (PMID = 19486582.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents; 80168379AG / Doxorubicin; Q20Q21Q62J / Cisplatin
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55. Mahomed F, Blok J, Grayson W: The squamous variant of eccrine porocarcinoma: a clinicopathological study of 21 cases. J Clin Pathol; 2008 Mar;61(3):361-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The squamous variant of eccrine porocarcinoma: a clinicopathological study of 21 cases.
  • AIM: Squamous differentiation in eccrine porocarcinoma (EPC) is an unusual phenomenon that has rarely been reported in the literature.
  • The prevalence of other cutaneous lesions and/or underlying systemic disease was also documented.
  • Seven patients developed other sun-induced skin tumours, three patients were renal transplant recipients, and two patients were HIV-positive, one of whom also suffered from albinism.
  • Six of the 11 patients in whom follow-up was available had an adverse outcome: local recurrence developed in one patient, one patient developed nodal metastases, and one patient experienced both local recurrence and nodal metastases, and of the three patients who died of disease, two developed distant metastases.
  • Further reports on this histological variant of EPC are required to determine whether a pathogenetic link does indeed exist or whether these tumours simply represent a unique variant of squamous cell carcinoma with divergent acrosyringial differentiation.
  • [MeSH-major] Acrospiroma / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Immunocompromised Host. Lymphatic Metastasis. Male. Middle Aged. Skin Neoplasms / complications. Skin Neoplasms / etiology. Skin Neoplasms / pathology. Sunlight / adverse effects

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  • (PMID = 17704263.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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56. Mahalingam M, Srivastava A, Hoang MP: Expression of stem-cell markers (cytokeratin 15 and nestin) in primary adnexal neoplasms-clues to etiopathogenesis. Am J Dermatopathol; 2010 Dec;32(8):774-9
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  • [Title] Expression of stem-cell markers (cytokeratin 15 and nestin) in primary adnexal neoplasms-clues to etiopathogenesis.
  • BACKGROUND: The overlap in histopathologic features and immunoprofile of eccrine and apocrine neoplasms confounds basic issues relating to lineage of these entities.
  • METHODS: We evaluated expression of follicular stem-cell markers, cytokeratin (CK) 15 and nestin, in 78 benign and 23 malignant adnexal neoplasms.
  • RESULTS: CK15 and nestin expression were noted in 39 of 78 (50%) and 36 of 78 (46%) cases in the benign group, respectively (8 cutaneous mixed tumor, 10 hidradenoma papilliferum, 9 apocrine cystadenoma, 11 cylindroma and/or spiradenoma, and 9 poroma/dermal duct tumor).
  • CK15 and nestin expression were noted in 11 of 23 (48%) and 7 of 23 (30%) cases in the malignant group, respectively (6 microcystic adnexal carcinoma, 7 porocarcinoma, and 9 eccrine carcinoma).
  • Except 1, both markers were negative in 4 syringocystadenoma papilliferum, 10 hidradenoma, 1 syringofibroadenoma, 10 syringoma, 1 eccrine adenoma, 8 poroma/dermal duct tumor, 5 eccrine hidrocystoma, and 1 apocrine carcinoma.
  • CONCLUSIONS: Given that follicular germinative cells give rise to the folliculosebaceous apocrine unit, expression of CK15 and nestin in the majority of cutaneous mixed tumor, hidradenoma papilliferum, apocrine cystadenoma, and cylindroma/spiradenoma is suggestive of an apocrine origin/differentiation of these neoplasms.
  • Reinforcing this and a novel finding of our study is the preferential expression of nestin in myoepithelial cells of these lesions.
  • [MeSH-major] Apocrine Glands / chemistry. Biomarkers, Tumor / analysis. Eccrine Glands / chemistry. Intermediate Filament Proteins / analysis. Keratin-15 / analysis. Neoplasms, Adnexal and Skin Appendage / chemistry. Neoplastic Stem Cells / chemistry. Nerve Tissue Proteins / analysis. Sweat Gland Neoplasms / chemistry
  • [MeSH-minor] Boston. Cell Lineage. Diagnosis, Differential. Humans. Immunohistochemistry. Nestin. Predictive Value of Tests

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  • (PMID = 20700038.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Intermediate Filament Proteins; 0 / KRT15 protein, human; 0 / Keratin-15; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin
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57. Al Baghli A, Reddy SS, Reddy MA: Malignant nodular hidradenoma of the eyelid: a rare sweat gland tumor. Middle East Afr J Ophthalmol; 2010 Oct;17(4):374-6
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  • [Title] Malignant nodular hidradenoma of the eyelid: a rare sweat gland tumor.
  • We report a case of malignant nodular hidradenoma in a middle-aged man, who presented with a nodular swelling in the eyelid.
  • The tumor was similar to its benign counterpart but had additional features such as surface ulceration, numerous mitiotic figures, and an infiltrative growth pattern.
  • Malignant forms of hidradenomas are unusual and the possibility this variant should be considered in the differential diagnosis of eyelid tumors.

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  • (PMID = 21180442.001).
  • [ISSN] 0975-1599
  • [Journal-full-title] Middle East African journal of ophthalmology
  • [ISO-abbreviation] Middle East Afr J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2991459
  • [Keywords] NOTNLM ; Eccrine Glands / Nodular Hidradenoma / Sweat Gland Tumor
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58. Frerichs O, Raute-Kreinsen U, Brüner S, Fansa H: [Malignant eccrine poroma]. Handchir Mikrochir Plast Chir; 2006 Jun;38(3):185-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Malignant eccrine poroma].
  • INTRODUCTION: Malignant eccrine poroma is a very rare tumour of the sweat glands with high malignancy and presenting with a polymorph clinical and histological picture.
  • CASE REPORT: We describe the case of a 99-year-old patient with a malignant poroma on the buttock.
  • [MeSH-major] Acrospiroma. Sweat Gland Neoplasms
  • [MeSH-minor] Aged. Aged, 80 and over. Buttocks. Diagnosis, Differential. Female. Humans. Skin Transplantation. Sweat Glands / pathology. Treatment Outcome

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  • (PMID = 16883504.001).
  • [ISSN] 0722-1819
  • [Journal-full-title] Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Mikrochirurgie der Peripheren Nerven und Gefässe : Organ der Vereinigung der Deutschen Plastischen Chirurgen
  • [ISO-abbreviation] Handchir Mikrochir Plast Chir
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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59. Kamiya H, Kitajima Y, Ban M: Bowen's disease with invasive adnexal carcinoma: the pluripotential nature of Bowen's disease cells. J Dermatol; 2006 Dec;33(12):858-64
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  • [Title] Bowen's disease with invasive adnexal carcinoma: the pluripotential nature of Bowen's disease cells.
  • Bowen's disease rarely exhibits multiple combinations of premalignant and/or malignant skin lesions.
  • Bowen's disease with invasive adnexal carcinoma was originally described by Kao, but is not well recognized by clinicians due to its rarity and lack of specific clinical features of this condition.
  • Herein, we describe three unusual cases of Bowen's disease with invasive adnexal carcinoma.
  • The plaque lesions possessed clinical features typical of Bowen's disease.
  • In cases 1 and 3, we confirmed the adnexal tumor within tumors of Bowen's disease, the diagnosis of which is eccrine porocarcinoma.
  • Immunohistochemically, the tumor cells of Bowen's disease and the adnexal carcinoma differed in antigenicities.
  • The present cases support a notion that Bowen's disease maintains a pluripotential nature.
  • [MeSH-major] Bowen's Disease / pathology. Carcinoma, Skin Appendage / pathology. Cell Transformation, Neoplastic / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Acrospiroma / pathology. Aged. Aged, 80 and over. Female. Humans. Neoplasm Invasiveness. Neoplasms, Basal Cell / pathology

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  • (PMID = 17169090.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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60. Allende I, Gardeazabal J, Acebo E, Díaz-Pérez JL: [Pigmented eccrine poroma]. Actas Dermosifiliogr; 2008 Jul-Aug;99(6):496-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pigmented eccrine poroma].
  • [Transliterated title] Poroma ecrino pigmentado.
  • [MeSH-major] Acrospiroma / diagnosis. Fingers. Skin Pigmentation. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Melanoma / diagnosis. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 18558065.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
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61. Jagdeo J, Robinson-Bostom L, Long T: Unusual clinical presentation of benign eccrine poroma. J Am Acad Dermatol; 2006 Apr;54(4):733-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual clinical presentation of benign eccrine poroma.
  • [MeSH-major] Acrospiroma / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 16546606.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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62. Mote DG, Ramamurti T, Naveen Babu B: Nodular hidradenoma of the breast: A case report with literature review. Indian J Surg; 2009 Feb;71(1):43-5
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  • [Title] Nodular hidradenoma of the breast: A case report with literature review.
  • Nodular hidradenoma or clear cell hidradenoma is a rare skin adenexal tumor which arises from eccrine sweat glands.
  • Skin adenexal tumors situated in the breast parenchyma are still very rare and is one of the differential diagnoses of breast tumors.
  • Failure to identify its morphologic features may lead to a mistaken diagnosis and over treatment.
  • Final diagnosis of nodular hidradenoma was made only after excision biopsy as fi ne needle aspiration cytology was inconclusive.

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  • [Cites] J Surg Oncol. 1986 Mar;31(3):191-8 [3014220.001]
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  • (PMID = 23133109.001).
  • [ISSN] 0972-2068
  • [Journal-full-title] The Indian journal of surgery
  • [ISO-abbreviation] Indian J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3452564
  • [Keywords] NOTNLM ; Adenexal tumor / Carcinoma breast / Nodular hidradenoma
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63. Jain R, Prabhakaran VC, Huilgol SC, Gehling N, James CL, Selva D: Eccrine porocarcinoma of the upper eyelid. Ophthal Plast Reconstr Surg; 2008 May-Jun;24(3):221-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eccrine porocarcinoma of the upper eyelid.
  • Eccrine porocarcinoma is an unusual, locally aggressive tumor with a significant risk of metastasis and recurrence after surgical excision.
  • We describe a 70-year-old man who was examined for right upper eyelid eccrine porocarcinoma that was treated with Mohs surgery.
  • Eccrine porocarcinoma should be considered in the differential diagnosis of malignant eyelid tumors.
  • [MeSH-major] Acrospiroma / pathology. Eyelid Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18520840.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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64. Battistella M, Langbein L, Peltre B, Cribier B: From hidroacanthoma simplex to poroid hidradenoma: clinicopathologic and immunohistochemic study of poroid neoplasms and reappraisal of their histogenesis. Am J Dermatopathol; 2010 Jul;32(5):459-68
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] From hidroacanthoma simplex to poroid hidradenoma: clinicopathologic and immunohistochemic study of poroid neoplasms and reappraisal of their histogenesis.
  • BACKGROUND: Poroid neoplasms comprise classic poroma (P), hidroacanthoma simplex (HS), dermal duct tumor (DDT), and poroid hidradenoma (PH).
  • Poroid cells in P have recently been identified as keratinocytes of the lowermost acrosyringium and the sweat duct ridge.
  • METHODS: 202 P, 11 HS, 17 DDT, 31 PH, and 5 composite tumors were examined under light microscopy, and 11, 9, 10, 15, and 2, respectively, by immunohistochemistry using anti-keratin antibodies, in particular, anti-K77, specific for luminal cells of the eccrine dermal sweat duct, and Ki-67 antibody.
  • Whereas P, DDT, and PH displayed unspecific clinical aspects, HS had most frequently the aspect of a large seborrheic keratosis with well-defined borders.
  • CONCLUSIONS: Our data demonstrate the common histogenesis of the 4 poroid neoplasms, which seem to derive from the basal keratinocytes of the sweat duct ridge and the lower acrosyringium.
  • The variable length of the sweat duct ridge may account for the variety of poroid neoplasms, according to the site of tumor induction along this structure.
  • [MeSH-major] Acanthoma / pathology. Acrospiroma / pathology. Keratinocytes / pathology. Keratins / metabolism. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Dermis / metabolism. Dermis / pathology. Female. Humans. Immunohistochemistry. Ki-67 Antigen / metabolism. Male. Middle Aged. Necrosis. Retrospective Studies. Sweat Glands / metabolism. Sweat Glands / pathology. Young Adult

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  • (PMID = 20571345.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 68238-35-7 / Keratins
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65. Ohata U, Hara H, Suzuki H: Pigmented eccrine poroma occurring on the scalp: Derivation of melanocytes in the tumor. Am J Dermatopathol; 2006 Apr;28(2):138-41
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  • [Title] Pigmented eccrine poroma occurring on the scalp: Derivation of melanocytes in the tumor.
  • [MeSH-major] Acrospiroma / pathology. Head and Neck Neoplasms / pathology. Melanocytes / pathology. Scalp / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Carcinoembryonic Antigen / analysis. Cell Nucleus / ultrastructure. Cytoplasmic Granules / ultrastructure. Diagnosis, Differential. Humans. Intercellular Junctions / ultrastructure. Male. Melanins / analysis. Nevus, Pigmented / diagnosis

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  • (PMID = 16625076.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Melanins
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66. Souvatzidis P, Sbano P, Mandato F, Fimiani M, Castelli A: Malignant nodular hidradenoma of the skin: report of seven cases. J Eur Acad Dermatol Venereol; 2008 May;22(5):549-54
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  • [Title] Malignant nodular hidradenoma of the skin: report of seven cases.
  • BACKGROUND: Malignant nodular hidradenoma (MNH) is an infrequent, highly malignant, primary skin tumour derived from eccrine sweat glands.
  • MNH has very poor prognosis, high recurrence and a high rate of metastases.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Skin Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Combined Modality Therapy. Fatal Outcome. Female. Humans. Male. Middle Aged. Prognosis. Skin / pathology

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  • (PMID = 18410617.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 29
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67. Thamboo TP, Tan LH, Tan SY: Expression of Bcl-x in normal skin and benign cutaneous adnexal tumors. J Cutan Pathol; 2006 Jan;33(1):27-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of Bcl-x in normal skin and benign cutaneous adnexal tumors.
  • Little is known about the expression of Bcl-x in cutaneous adnexal structures and benign cutaneous adnexal tumors.
  • METHODS: Tissues from 31 cases of benign cutaneous adnexal tumors (five trichofolliculomas, five trichoepitheliomas, two sebaceous adenomas, five apocrine hidradenomas, five eccrine poromas, five eccrine spiradenomas, and four syringomas) were immunostained for Bcl-x.
  • Sebaceous gland cells showed strong staining.
  • Apocrine gland cells showed weak to moderate staining.
  • No staining was seen in eccrine gland cells.
  • In sebaceous adenomas, the sebaceous cells showed strong staining while the basaloid cells were negative.
  • The cells of apocrine hidradenomas showed patchy weak staining.
  • No staining was seen in eccrine poromas, eccrine spiradenomas, and syringomas.
  • CONCLUSIONS: The degree of Bcl-x expression in cutaneous adnexal glandular structures appears to be related to their mode of secretion, being strongest in cells with apoptotic degradation of the entire cell (sebocytes).
  • This pattern is recapitulated in the corresponding benign cutaneous adnexal tumors.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / metabolism. Skin / metabolism. Skin Neoplasms / metabolism. bcl-X Protein / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Epidermis / metabolism. Epidermis / pathology. Humans. Immunoenzyme Techniques. Sebaceous Glands / metabolism. Sebaceous Glands / pathology. Sweat Glands / metabolism. Sweat Glands / pathology

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  • (PMID = 16441408.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / bcl-X Protein
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68. Yamashita H, Kadono T, Tamaki K, Nakagawa K: Interesting response to concurrent chemoradiation in metastatic eccrine porocarcinoma. J Dermatol; 2008 Sep;35(9):606-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Interesting response to concurrent chemoradiation in metastatic eccrine porocarcinoma.
  • [MeSH-major] Acrospiroma / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18837710.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Japan
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69. Kampshoff JL, Cogbill TH: Unusual skin tumors: Merkel cell carcinoma, eccrine carcinoma, glomus tumors, and dermatofibrosarcoma protuberans. Surg Clin North Am; 2009 Jun;89(3):727-38
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual skin tumors: Merkel cell carcinoma, eccrine carcinoma, glomus tumors, and dermatofibrosarcoma protuberans.
  • This article discusses the epidemiology, etiology, presentation, pathology, evaluation and staging, and treatment of unusual skin tumors, such as Merkel cell carcinoma, eccrine carcinoma, glomus tumors, and dermatofibrosarcoma protuberans.
  • [MeSH-major] Acrospiroma. Carcinoma, Merkel Cell. Dermatofibrosarcoma. Glomus Tumor. Skin Neoplasms
  • [MeSH-minor] Combined Modality Therapy. Diagnosis, Differential. Humans. Incidence. Neoplasm Staging / methods. Prognosis. Sweat Gland Neoplasms / diagnosis. Sweat Gland Neoplasms / epidemiology. Sweat Gland Neoplasms / therapy. United States / epidemiology


70. Avilés-Izquierdo JA, Velázquez-Tarjuelo D, Lecona-Echevarría M, Lázaro-Ochaita P: [Dermoscopic features of eccrine poroma]. Actas Dermosifiliogr; 2009 Mar;100(2):133-6
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  • [Title] [Dermoscopic features of eccrine poroma].
  • [Transliterated title] Características dermatoscópicas del poroma ecrino.
  • Eccrine poroma is a benign adnexal neoplasm that clinically may mimic malignant skin tumors such as squamous cell carcinoma and amelanotic melanoma.
  • The dermoscopic features of pigmented and nonpigmented eccrine poroma have recently been described.
  • We present 2 cases of eccrine poroma, with their dermoscopic features.
  • The lesions were characterized by multiple red lacunes and a polymorphous vascular pattern in both cases.
  • Dermoscopy can improve the clinical diagnosis of this benign adnexal skin tumor.
  • [MeSH-major] Acrospiroma / pathology. Dermoscopy. Foot Diseases / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Buttocks. Diagnosis, Differential. Female. Humans. Skin Neoplasms / diagnosis

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  • (PMID = 19445878.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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71. Al-Qattan MM, Al-Turaiki TM, Al-Oudah N, Arab K: Benign eccrine poroma of the dorsum of the hand: predilection for the nail fold and P53 positivity. J Hand Surg Eur Vol; 2009 Jun;34(3):402-3
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  • [Title] Benign eccrine poroma of the dorsum of the hand: predilection for the nail fold and P53 positivity.
  • [MeSH-major] Acrospiroma / pathology. Precancerous Conditions / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Disease Progression. Humans. Male. Middle Aged. Nails. Thumb. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 19457912.001).
  • [ISSN] 2043-6289
  • [Journal-full-title] The Journal of hand surgery, European volume
  • [ISO-abbreviation] J Hand Surg Eur Vol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53
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72. Schadt CR, Boyd AS: Eccrine syringofibroadenoma with co-existent squamous cell carcinoma. J Cutan Pathol; 2007 Dec;34 Suppl 1:71-4
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  • [Title] Eccrine syringofibroadenoma with co-existent squamous cell carcinoma.
  • Eccrine syringofibroadenoma (ESFA) is a rare, benign adnexal tumor arising most often on the extremities of elderly individuals.
  • The cords contain scattered ductal structures lined with cuboidal cells resembling eccrine ducts.
  • The co-existence of ESFA with squamous cell carcinoma has been described, eliciting the term eccrine syringofibroadenoma.
  • The differential diagnosis includes poroma, porocarcinoma, fibroepithelioma of Pinkus and clear cell acanthoma.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Carcinoma, Squamous Cell / pathology. Eccrine Glands / pathology. Fibroadenoma / pathology. Neoplasms, Multiple Primary / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Acanthoma / diagnosis. Acrospiroma / diagnosis. Adenocarcinoma / diagnosis. Diagnosis, Differential. Female. Humans. Middle Aged. Neoplasms, Fibroepithelial / diagnosis

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  • (PMID = 17997744.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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73. Vandeweyer E, Renorte C, Musette S, Gilles A: Eccrine porocarcinoma: a case report. Acta Chir Belg; 2006 Jan-Feb;106(1):121-3
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  • [Title] Eccrine porocarcinoma: a case report.
  • Eccrine porocarcinoma is a rare malignant sweat gland tumour.
  • Diagnosis of eccrine porocarcinoma on clinical observation only is quite impossible.
  • Here we present the case of a 64-year-old female patient with a small reddish nodule of the knee that, on histological evaluation, proved to be an eccrine porocarcinoma.
  • [MeSH-major] Acrospiroma / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 16612934.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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74. Monteagudo B, Iglesias B, de la Torre C, Paredes C, Vázquez-Blanco M, Ginarte M, Labandeira J: [Poroid hidradenoma]. Actas Dermosifiliogr; 2005 Jul-Aug;96(6):398-9
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  • [Title] [Poroid hidradenoma].
  • [Transliterated title] Hidroadenoma poroide.
  • Poroid hidradenoma is a recently described variant of eccrine poroma.
  • This neoplasm presents structural findings of hidradenoma (solid and cystic areas) and cytological characteristics of poromas (poroid and cuticular cells, the latter showing ductal differentiation).
  • We present a case of poroid hidradenoma in a 74-year-old woman, who consulted her physician because of a nodular lesion on the left buttock.
  • [MeSH-major] Acrospiroma / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 16476263.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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75. Mahlberg MJ, McGinnis KS, Draft KS, Fakharzadeh SS: Multiple eccrine poromas in the setting of total body irradiation and immunosuppression. J Am Acad Dermatol; 2006 Aug;55(2 Suppl):S46-9
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  • [Title] Multiple eccrine poromas in the setting of total body irradiation and immunosuppression.
  • Eccrine poromas are benign, adnexal tumors that most often occur as a solitary lesion on the palm or sole.
  • The occurrence of multiple eccrine poromas is extremely rare.
  • In this report, we describe the development of several eccrine poromas in an acral distribution in a 42-year-old man.
  • As a complication of the bone marrow transplant, the patient developed chronic graft-versus-host disease, which was treated with immunosuppressive therapy.
  • We discuss this patient and review the available literature regarding multiple eccrine poromas.
  • [MeSH-major] Acrospiroma / etiology. Graft vs Host Disease / drug therapy. Immunosuppressive Agents / adverse effects. Precursor Cell Lymphoblastic Leukemia-Lymphoma / radiotherapy. Sweat Gland Neoplasms / etiology. Whole-Body Irradiation / adverse effects
  • [MeSH-minor] Adult. Bone Marrow Transplantation / adverse effects. Chronic Disease. Combined Modality Therapy. Humans. Male. Neoplasms, Radiation-Induced / immunology. Neoplasms, Radiation-Induced / pathology

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  • (PMID = 16843124.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
  • [Number-of-references] 21
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76. Chiu HH, Lan CC, Wu CS, Chen GS, Tsai KB, Chen PH: A single lesion showing features of pigmented eccrine poroma and poroid hidradenoma. J Cutan Pathol; 2008 Sep;35(9):861-5
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  • [Title] A single lesion showing features of pigmented eccrine poroma and poroid hidradenoma.
  • Poroid hidradenoma (PH) is a variant of poroma.
  • This neoplasm shows architectural characteristics of hidradenoma (tumor cells confined entirely within the dermis in both solid and cystic components) and cytologic characteristics of poroid neoplasm (poroid and cuticular cells, the latter showing ductal differentiation).
  • We herein document a case of single poroid lesion with the features of both eccrine poroma and PH.
  • The patient was a 55-year-old woman with a pigmented nodular lesion on her upper back for 7 years.
  • The histopathologic features of the lesion were consistent with those of eccrine poroma and PH.
  • Unlike most eccrine poromas, this case was pigmented, clinically and microscopically.
  • [MeSH-major] Acrospiroma / pathology. Pigmentation Disorders / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Cell Nucleus / metabolism. Cell Nucleus / pathology. Female. Humans. Immunohistochemistry. Ki-67 Antigen / metabolism. Melanins / metabolism. Middle Aged. Pigmentation

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  • (PMID = 18422687.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Melanins
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77. Sheff JS, Macdougall DB: Unusual case of porocarcinoma of the foot with no clinically evident dermatologic manifestations. J Foot Ankle Surg; 2005 Sep-Oct;44(5):412-4
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  • Eccrine poromas are solitary nodules that predilect the soles of the foot.
  • When this occurs, the growth is classified as a malignant eccrine poroma, or porocarcinoma.
  • A case of a 39-year-old woman who originally presented with an incidental plantar skin lesion that was later diagnosed as a porocarcinoma is reported.
  • The patient underwent local excision of the lesion and a sentinel node biopsy.
  • This case has been presented to demonstrate that skin lesions with minimal abnormalities of skin texture or color, and slight elevation as the only dermatologic manifestation, can represent a malignancy.
  • [MeSH-major] Acrospiroma / diagnosis. Forefoot, Human / pathology. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 16210163.001).
  • [ISSN] 1067-2516
  • [Journal-full-title] The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
  • [ISO-abbreviation] J Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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78. Nair PS: A clinicopathologic study of skin appendageal tumors. Indian J Dermatol Venereol Leprol; 2008 Sep-Oct;74(5):550
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A clinicopathologic study of skin appendageal tumors.
  • BACKGROUND: Appendageal skin tumors belong to a heterogenous group of tumors with specific histopathology.
  • The aim of this study is to determine the pattern of appendageal tumors in skin biopsies done in our department.
  • METHODS: This is a 3-year retrospective descriptive study of all patients who were diagnosed to have skin appendageal tumors in our department, and the diagnoses were confirmed by histopathology.
  • The tumors were classified as eccrine, hair, sebaceous, and apocrine after a detailed examination of routine hematoxylin and eosin sections.
  • Tumors with eccrine differentiation constituted the maximum, 17 cases (51.5%); followed by tumors with hair differentiation, 12 cases (36.36%); tumors with sebaceous differentiation, 2 cases (6.06%); and apocrine tumors, 2 cases (6.06%).
  • Syringoma constituted the commonest eccrine tumor, 14 cases (42.42%); while trichoepithelioma was the commonest hair tumor, 9 cases (27.27%).
  • The other eccrine tumors were eccrine spiradenoma, 2 cases (6.06%); and nodular hidradenoma, 1 (3.03%).
  • Syringocystadenoma papilliferum, 1 (3.03%); and cylindroma, 1 (3.03%), constituted the apocrine tumors.
  • CONCLUSIONS: Appendageal skin tumors are relatively uncommon.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Skin Neoplasms / pathology

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  • (PMID = 19086136.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] India
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79. Cowden A, Dans M, Militello G, Junkins-Hopkins J, Van Voorhees AS: Eccrine porocarcinoma arising in two African American patients: distinct presentations both treated with Mohs micrographic surgery. Int J Dermatol; 2006 Feb;45(2):146-50
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  • [Title] Eccrine porocarcinoma arising in two African American patients: distinct presentations both treated with Mohs micrographic surgery.
  • Abstract Background Eccrine porocarcinoma (EPC) is a rare, malignant adnexal tumor that has been reported only three times specifically in African American individuals.
  • [MeSH-major] Acrospiroma / pathology. African Continental Ancestry Group. Sweat Gland Neoplasms / pathology

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  • (PMID = 16445507.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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80. Plaza JA, Ortega PF, Stockman DL, Suster S: Value of p63 and podoplanin (D2-40) immunoreactivity in the distinction between primary cutaneous tumors and adenocarcinomas metastatic to the skin: a clinicopathologic and immunohistochemical study of 79 cases. J Cutan Pathol; 2010 Apr;37(4):403-10
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  • [Title] Value of p63 and podoplanin (D2-40) immunoreactivity in the distinction between primary cutaneous tumors and adenocarcinomas metastatic to the skin: a clinicopathologic and immunohistochemical study of 79 cases.
  • The distinction of metastatic carcinomas to the skin from poorly differentiated primary cutaneous carcinomas and sometimes primary benign adnexal tumors can pose a significant diagnostic challenge.
  • The purpose of this study was to evaluate the role of p63 and podoplanin (D2-40) immunoreactivity for separating primary skin tumors vs. cutaneous metastases of carcinomas from internal organs.
  • The 37 primary cutaneous tumors included 14 cases of benign adnexal tumors, 9 malignant skin adnexal neoplasms, and 14 primary squamous and basal cell carcinomas.
  • The 42 metastatic adenocarcinomas all corresponded to metastases from patients with a well-documented history of a primary tumor at another location.
  • We found variable positivity with podoplanin in all primary cutaneous neoplasms including spiradenoma (6/6), hidradenoma (2/4), cylindroma (3/3), desmoplastic trichilemmoma (1/1), poorly differentiated squamous cell carcinoma (4/4), sebaceous carcinoma (1/1), basal cell carcinoma (4/10), trichilemmal carcinoma (2/2), eccrine carcinoma (3/3), microcystic adnexal carcinoma (1/1), adnexal carcinoma NOS (1/1), and porocarcinoma (1/1).
  • Sensitivity, specificity, and positive and negative predictive values of podoplanin and p63 immunoreactivity to separate primary skin neoplasms from metastatic carcinomas were 78.4, 100.0, 100.0 and 84.0% for podoplanin, respectively, and 100.0, 100.0, 100.0 and 100.0% for p63, respectively.
  • The differences in p63 and podoplanin immunohistochemical expression between primary skin tumors and metastatic carcinomas to the skin were statistically significant (p < 0, 0001).
  • The results of our study suggest that the combined expression of p63 and podoplanin are a useful adjunct for the diagnosis of skin tumors in the clinical setting of a questionable metastasis and may be relatively specific for distinguishing primary skin tumors from metastatic carcinomas to the skin.
  • [MeSH-major] Adenocarcinoma / metabolism. Membrane Glycoproteins / metabolism. Membrane Proteins / metabolism. Skin / metabolism. Skin Neoplasms / metabolism

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  • (PMID = 20377670.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / CKAP4 protein, human; 0 / Membrane Glycoproteins; 0 / Membrane Proteins; 0 / PDPN protein, human
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81. Burra UK, Singh A, Saxena S: Eccrine porocarcinoma (malignant eccrine poroma): a case report. Dermatol Online J; 2005;11(2):17
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eccrine porocarcinoma (malignant eccrine poroma): a case report.
  • Eccrine porocarcinoma is a rare malignancy of eccrine sweat gland usually presenting as a long-standing growth on the lower extremity.
  • It may arise in a pre-existing eccrine poroma.
  • A case presenting as nodular swelling over the dorsum of left hand in a 56-year-old man is described.
  • [MeSH-major] Acrospiroma / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 16150225.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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82. Cho SB, Roh MR, Yun M, Yun SK, Lee MG, Chung KY: (18)F-fluorodeoxyglucose positron emission tomography detection of eccrine porocarcinoma. Br J Dermatol; 2005 Feb;152(2):372-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] (18)F-fluorodeoxyglucose positron emission tomography detection of eccrine porocarcinoma.
  • [MeSH-major] Acrospiroma / radionuclide imaging. Sweat Gland Neoplasms / radionuclide imaging

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  • (PMID = 15727659.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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83. Lan CC, Yu HS, Wu CS, Tsai KB, Wen CH, Chen GS: Pigmented eccrine poroma with enhanced endothelin-1 expression: implications for mechanism of hyperpigmentation. Br J Dermatol; 2005 May;152(5):1070-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pigmented eccrine poroma with enhanced endothelin-1 expression: implications for mechanism of hyperpigmentation.
  • [MeSH-major] Acrospiroma / complications. Endothelin-1 / metabolism. Facial Neoplasms / complications. Hyperpigmentation / etiology. Sweat Gland Neoplasms / complications

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  • (PMID = 15888178.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Endothelin-1
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