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1. Almazán-Fernández FM, Fernández-Pugnaire MA, Hernández-Gil J, Arias-Santiago S, Abad-Romero J, Serrano-Ortega S, Naranjo-Sintes R: Homogeneous blue pattern: A rare presentation in an acral congenital melanocytic nevus. Dermatol Online J; 2010;16(8):10
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  • [Title] Homogeneous blue pattern: A rare presentation in an acral congenital melanocytic nevus.
  • Acral melanocytic nevi are relatively frequent in the palmoplantar location.
  • However, there are few reports on the dermoscopic pattern of acral congenital nevi.
  • The homogeneous blue pattern is typical of blue nevus and is not typical of acral localization and metastasis of cutaneous melanoma.
  • However, this pattern should be considered characteristic of acral congenital nevus.
  • [MeSH-major] Nevus, Blue / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 20804687.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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2. Iyatomi H, Oka H, Celebi ME, Ogawa K, Argenziano G, Soyer HP, Koga H, Saida T, Ohara K, Tanaka M: Computer-based classification of dermoscopy images of melanocytic lesions on acral volar skin. J Invest Dermatol; 2008 Aug;128(8):2049-54
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  • [Title] Computer-based classification of dermoscopy images of melanocytic lesions on acral volar skin.
  • We describe a fully automated system for the classification of acral volar melanomas.
  • We used a total of 213 acral dermoscopy images (176 nevi and 37 melanomas).
  • The features used in the melanoma-nevus classifier and the parallel ridge detector have significant overlap.
  • [MeSH-major] Dermoscopy / methods. Diagnosis, Computer-Assisted / methods. Melanoma / classification. Nevus / classification. Skin Neoplasms / classification

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  • (PMID = 18323788.001).
  • [ISSN] 1523-1747
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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3. Lisovsky M, Hoang MP, Dresser KA, Kapur P, Bhawan J, Mahalingam M: Apolipoprotein D in CD34-positive and CD34-negative cutaneous neoplasms: a useful marker in differentiating superficial acral fibromyxoma from dermatofibrosarcoma protuberans. Mod Pathol; 2008 Jan;21(1):31-8
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  • [Title] Apolipoprotein D in CD34-positive and CD34-negative cutaneous neoplasms: a useful marker in differentiating superficial acral fibromyxoma from dermatofibrosarcoma protuberans.
  • To corroborate these results, we sought to ascertain the utility of Apo D by investigating its sensitivity and specificity in a variety of CD34-positive and CD34-negative cutaneous neoplasms including superficial acral fibromyxoma, sclerotic fibromas, and cellular dermatofibromas.
  • Of interest, we found absence of Apo D expression in all four cases of superficial acral fibromyxoma.
  • Its principal use as an immunohistochemical adjunct lies in its utility in differentiating superficial acral fibromyxoma from dermatofibrosarcoma protuberans.
  • [MeSH-major] Antigens, CD34 / analysis. Apolipoproteins D / analysis. Biomarkers, Tumor / analysis. Dermatofibrosarcoma / diagnosis. Fibroma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Giant Cell Tumors / chemistry. Giant Cell Tumors / diagnosis. Giant Cell Tumors / immunology. Histiocytoma, Benign Fibrous / chemistry. Histiocytoma, Benign Fibrous / diagnosis. Histiocytoma, Benign Fibrous / immunology. Humans. Immunohistochemistry. Melanoma / chemistry. Melanoma / diagnosis. Melanoma / immunology. Nevus, Pigmented / chemistry. Nevus, Pigmented / diagnosis. Nevus, Pigmented / immunology. Reproducibility of Results. United States

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  • (PMID = 17885669.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Apolipoproteins D; 0 / Biomarkers, Tumor
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4. Martín Hernández JM, Donat Colomer J, Monteagudo Castro C, Fernández-Delgado Cerdá R, Alonso Usero V, Jordá Cuevas E: [Acral eruptive nevi after chemotherapy in children with acute lymphoblastic leukemia]. An Pediatr (Barc); 2006 Sep;65(3):260-2
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  • [Title] [Acral eruptive nevi after chemotherapy in children with acute lymphoblastic leukemia].
  • [MeSH-major] Antineoplastic Agents / adverse effects. Foot Diseases / chemically induced. Nevus / chemically induced. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Skin Neoplasms / chemically induced


5. Zalaudek I, Zanchini R, Petrillo G, Ruocco E, Soyer HP, Argenziano G: Dermoscopy of an acral congenital melanocytic nevus. Pediatr Dermatol; 2005 May-Jun;22(3):188-91
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  • [Title] Dermoscopy of an acral congenital melanocytic nevus.
  • Dermoscopy improves the early detection of melanoma while reducing the number of unnecessary excisions of benign pigmented skin lesions.
  • Dermoscopically, congenital melanocytic nevi are often characterized by the presence of a cobblestone pattern, but to date, little is known about the dermoscopic features of acral congenital melanocytic nevi.
  • We report an acral congenital melanocytic nevus typified by the presence of three different dermoscopic patterns that are commonly seen in acquired melanocytic nevi of palms and soles.
  • [MeSH-major] Dermoscopy. Melanoma / congenital. Nevus, Pigmented / congenital. Skin Neoplasms / congenital

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  • (PMID = 15916562.001).
  • [ISSN] 0736-8046
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. Elder DE: Precursors to melanoma and their mimics: nevi of special sites. Mod Pathol; 2006 Feb;19 Suppl 2:S4-20
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  • Nevi of special sites have been identified as nevi that may show atypical features suggestive of a dysplastic nevus or of a melanoma.
  • Nevi of genital skin, acral skin, and flexural skin are among the most important 'nevi of special sites'.
  • It is important, in considering the differential diagnosis of a lesion in a special site, to avoid overcalling such a lesion as a melanoma or a dysplastic nevus because this could lead to excessive treatment.
  • Conversely, it is important to avoid undercalling a lesion that is a dysplastic nevus or a melanoma as a nevus of special sites, because in this circumstance a patient could lose the opportunity either for surveillance to recognize a developing melanoma at an early, curable stage, or for definitive treatment of an established malignancy.
  • [MeSH-major] Dysplastic Nevus Syndrome / pathology. Melanoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Melanocytes / pathology. Nevus, Pigmented / pathology

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  • (PMID = 16446715.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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7. Zalaudek I, Docimo G, Argenziano G: Using dermoscopic criteria and patient-related factors for the management of pigmented melanocytic nevi. Arch Dermatol; 2009 Jul;145(7):816-26
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  • STUDY SELECTION: The following relevant terms were used: dermoscopy, dermatoscopy, epiluminescence microscopy (ELM), surface microscopy, digital dermoscopy, digital dermatoscopy, digital epiluminescence microscopy, digital surface microscopy, melanocytic skin lesion, nevi, and pigmented skin lesions.
  • (3) pigment distribution (multifocal, central, eccentric, and uniform); and (4) special sites (face, acral areas, nail, and mucosa).
  • In addition, the following 6 factors related to the patient might influence the pattern of pigmentation of the individual nevi: age, skin type, history of melanoma, UV exposure, pregnancy, and growth dynamics.
  • [MeSH-major] Dermoscopy. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • (PMID = 19620566.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Grant] Austria / Austrian Science Fund FWF / / FWF/ V 9
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 118
  • [Other-IDs] NLM/ PMC2856040; NLM/ UKMS29678
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8. Lu S, Slominski A, Yang SE, Sheehan C, Ross J, Carlson JA: The correlation of TRPM1 (Melastatin) mRNA expression with microphthalmia-associated transcription factor (MITF) and other melanogenesis-related proteins in normal and pathological skin, hair follicles and melanocytic nevi. J Cutan Pathol; 2010 Apr;37 Suppl 1:26-40
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  • [Title] The correlation of TRPM1 (Melastatin) mRNA expression with microphthalmia-associated transcription factor (MITF) and other melanogenesis-related proteins in normal and pathological skin, hair follicles and melanocytic nevi.
  • OBJECTIVE: To assess the relationship between TRPM1 mRNA expression and the expression of MITF and nine other markers of melanocytes and melanin-related proteins by immunohistochemistry in normal skin, scars, hair follicles and ordinary melanocytic nevi.
  • METHODS: Samples of normal skin (n = 102; from tumor excisions and plastic procedures), scars (n = 5; from re-excision specimens) and compound melanocytic nevi (n = 4) were evaluated for the presence of TRPM1 mRNA transcripts as detected by chromogenic in situ hybridization (CISH).
  • Anogenital skin showed the highest and acral skin the lowest LI for TRPM1, MITF, S100 protein, Tyrosinase, Mel5 and HMB45.
  • Sun-damaged skin exhibited significantly increased LI as measured by MITF, S100 protein, Mart1, tyrosinase and HMB-45, but no differences for TRPM1.
  • MITF LI-TRPM1 LI = MITF+TRPM1--melanocytes) was significantly increased in site-matched skin (4.6 +/- 4.4 vs. 1.5 +/- 2.5, p = 0.01).
  • There was a suggestion of reduced LI in normal skin in the proximity of melanoma (from melanoma re-excision specimens) for S100, HMB45 and TRPM1 mRNA.
  • TRPM1 LI was significantly decreased in scars compared to normal skin (5.6 +/- 1.4 vs. 9.7 +/- 4.3, p = 0.02), this was reflected in an increase in the MITF-TRPM1 differential (9.6 +/- 7.5 vs. 3.2 +/- 3.1, p = 0.0001).
  • However, in normal skin, TRPM1 mRNA expression appears to be dynamic, labeling most but not all melanocytes, with variable expression ostensibly related to local environmental factors.

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  • (PMID = 20482673.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] ENG
  • [Grant] United States / NIAMS NIH HHS / AR / R01 AR052190; None / None / / R01 AR052190-04; United States / NIAMS NIH HHS / AR / AR052190; United States / NIAMS NIH HHS / AR / R01 AR052190-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / MITF protein, human; 0 / Microphthalmia-Associated Transcription Factor; 0 / RNA, Messenger; 0 / TRPM Cation Channels; 0 / TRPM1 protein, human; 581-05-5 / alpha-MSH
  • [Other-IDs] NLM/ NIHMS192683; NLM/ PMC2882198
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9. Garrido-Ríos AA, Carrera C, Puig S, Aguilera P, Salerni G, Malvehy J: Homogeneous blue pattern in an acral congenital melanocytic nevus. Dermatology; 2008;217(4):315-7
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  • [Title] Homogeneous blue pattern in an acral congenital melanocytic nevus.
  • Dermoscopy in acquired acral melanocytic nevi has been widely studied.
  • This is in contrast with the little information about the dermoscopic characteristics in congenital acral melanocytic nevi.
  • We report a 46-year-old man who was referred due to a lesion on his right sole present since childhood corresponding to an acral congenital nevus.
  • Dermoscopy showed a homogeneous blue pattern not previously described in acral benign tumors.
  • The homogeneous blue pattern has previously been associated with blue nevus and skin metastasis of melanoma.
  • The recognition of this pattern in benign acral congenital nevi is relevant in the clinical decision making concerning acral tumors.
  • [MeSH-major] Foot. Nevus, Pigmented / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Dermoscopy. Diagnosis, Differential. Humans. Male. Melanocytes / pathology. Middle Aged. Nevus, Blue / pathology

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  • [Copyright] 2008 S. Karger AG, Basel.
  • (PMID = 18714159.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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10. Takata M, Murata H, Saida T: Molecular pathogenesis of malignant melanoma: a different perspective from the studies of melanocytic nevus and acral melanoma. Pigment Cell Melanoma Res; 2010 Feb;23(1):64-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular pathogenesis of malignant melanoma: a different perspective from the studies of melanocytic nevus and acral melanoma.
  • The Clark model for melanoma progression emphasizes a series of histopathological changes beginning from benign melanocytic nevus to melanoma via dysplastic nevus.
  • Furthermore, it is suggested that many melanomas, including acral and mucosal melanomas, arise de novo, not from melanocytic nevus.
  • While mutations of the BRAF gene are frequent in melanomas on non-chronic sun damaged skin which are prevalent in Caucasians, acral and mucosal melanomas harbor mutations of the KIT gene as well as the amplifications of cyclin D1 or cyclin-dependent kinase 4 gene.
  • Amplifications of the cyclin D1 gene are detected in normal-looking 'field melanocytes', which represent a latent progression phase of acral melanoma that precedes the stage of atypical melanocyte proliferation in the epidermis.
  • [MeSH-major] Cell Transformation, Neoplastic / genetics. Gene Expression Regulation, Neoplastic / genetics. Melanoma / genetics. Mutation / genetics. Nevus, Pigmented / genetics. Skin Neoplasms / genetics

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  • (PMID = 19788535.001).
  • [ISSN] 1755-148X
  • [Journal-full-title] Pigment cell & melanoma research
  • [ISO-abbreviation] Pigment Cell Melanoma Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 136601-57-5 / Cyclin D1; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
  • [Number-of-references] 53
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11. Altamura D, Zalaudek I, Sera F, Argenziano G, Fargnoli MC, Rossiello L, Peris K: Dermoscopic changes in acral melanocytic nevi during digital follow-up. Arch Dermatol; 2007 Nov;143(11):1372-6
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  • [Title] Dermoscopic changes in acral melanocytic nevi during digital follow-up.
  • OBJECTIVE: To investigate changes in dermoscopic patterns of acquired acral melanocytic nevi (AAMN) over time.
  • DESIGN: Retrospective analysis of digital dermoscopic follow-up of 230 AAMN located on acral volar skin.
  • [MeSH-major] Dermoscopy. Diagnosis, Computer-Assisted. Extremities. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis

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  • [CommentIn] Arch Dermatol. 2007 Nov;143(11):1423-6 [18025367.001]
  • (PMID = 18025360.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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12. Braun RP, Thomas L, Kolm I, French LE, Marghoob AA: The furrow ink test: a clue for the dermoscopic diagnosis of acral melanoma vs nevus. Arch Dermatol; 2008 Dec;144(12):1618-20
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  • [Title] The furrow ink test: a clue for the dermoscopic diagnosis of acral melanoma vs nevus.
  • BACKGROUND: Dermoscopy is a helpful tool that can assist experienced users improve the diagnostic accuracy for pigmented lesions in acral sites.
  • The ink should be left on the skin for a few seconds to allow the ink to penetrate into the furrows.
  • The ink will at first diffusely color the entire skin surface.
  • The subsequent cotton swab wiping will only remove the ink on the skin overlying the ridges.
  • Conclusion The furrow ink test is a quick and easy method to facilitate the correct identification of furrows and ridges on volar skin and facilitates dermoscopic diagnosis of pigmented lesions in acral sites.
  • [MeSH-major] Dermoscopy / methods. Melanoma / diagnosis. Nevus / diagnosis. Skin Neoplasms / diagnosis


13. Ozdemir F, Karaarslan IK, Akalin T: Variations in the dermoscopic features of acquired acral melanocytic nevi. Arch Dermatol; 2007 Nov;143(11):1378-84
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  • [Title] Variations in the dermoscopic features of acquired acral melanocytic nevi.
  • OBJECTIVE: To investigate the dermoscopic features of acquired acral melanocytic nevi (AAMN) in a white population in Turkey.
  • [MeSH-major] Dermoscopy. Extremities. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis

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  • [CommentIn] Arch Dermatol. 2007 Nov;143(11):1423-6 [18025367.001]
  • (PMID = 18025361.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Ishihara Y, Saida T, Miyazaki A, Koga H, Taniguchi A, Tsuchida T, Toyama M, Ohara K: Early acral melanoma in situ: correlation between the parallel ridge pattern on dermoscopy and microscopic features. Am J Dermatopathol; 2006 Feb;28(1):21-7
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  • [Title] Early acral melanoma in situ: correlation between the parallel ridge pattern on dermoscopy and microscopic features.
  • In non-white populations, acral skin is the most prevalent site of malignant melanoma.
  • Early melanomas of this anatomic site are often misdiagnosed as melanocytic nevi, which are not uncommon on acral skin.
  • In fact, clinical and/or histopathological features of melanocytic nevi occasionally mimic those of early acral melanoma and vice versa, and thus differentiation of early acral melanoma from melanocytic nevus is sometimes very difficult for clinicians as well as for histopathologists.
  • Our dermoscopic investigation has revealed that the parallel ridge pattern, a band-like pigmentation on the ridges of the skin markings, is highly specific to malignant melanoma in situ on acral volar skin.
  • In the present study, we reviewed 22 acral melanocytic lesions that showed the parallel ridge pattern on dermoscopy but had very subtle clinical and/or histopathological presentations.
  • We diagnosed 20 of them as early melanoma in situ by careful histopathological examination, which revealed histopathological features very similar to those seen in macular portions of overt acral melanoma, but fundamentally different from features found in melanocytic nevi on acral skin.
  • In correspondence with their dermoscopic pattern, in these early lesions of acral melanomas, proliferation of solitary arranged melanocytes was mainly detected in the crista profunda intermedia, the epidermal rete ridge underlying the ridge of the skin marking.
  • The two remaining lesions were diagnosed as possible cases of acquired melanocytic nevus because of the formation of well-demarcated nests of melanocytes in the epidermal rete ridges.
  • We propose that a finding of preferential proliferation of solitary arranged melanocytes in the crista profunda intermedia is an important clue for the histopathological diagnosis of early phases of acral melanoma.
  • [MeSH-major] Dermoscopy / methods. Melanoma / pathology. Precancerous Conditions / pathology. Skin Neoplasms / pathology

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  • (PMID = 16456320.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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15. Kimoto M, Sakamoto M, Iyatomi H, Tanaka M: Three-dimensional melanin distribution of acral melanocytic nevi is reflected in dermoscopy features: analysis of the parallel pattern. Dermatology; 2008;216(3):205-12
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  • [Title] Three-dimensional melanin distribution of acral melanocytic nevi is reflected in dermoscopy features: analysis of the parallel pattern.
  • BACKGROUND: Acral melanocytic nevi have parallel patterns on dermoscopy; however, it is not understood why pigment distributions exhibit such patterns.
  • AIM: To clarify the reason why melanin distributions in acral melanocytic nevi exhibit a parallel pattern on dermoscopy.
  • METHODS: A serial sectioning perpendicular to the skin markings was performed, and each section was stained with modified Fontana-Masson staining to pick out melanin granules.
  • RESULTS: Melanin columns in the cornified layer were mainly seen in the dermoscopic images of acral melanocytic nevi.
  • CONCLUSION: Melanin columns in the cornified layer, not melanin in the basal layer, mainly contribute to the dermoscopic pattern of acral melanocytic nevi.
  • [MeSH-major] Dermoscopy. Foot Diseases / pathology. Hand / pathology. Imaging, Three-Dimensional / methods. Melanins / analysis. Nevus, Pigmented / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Humans. Image Processing, Computer-Assisted. Silver Nitrate. Skin / metabolism. Skin / pathology

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  • [CommentIn] Dermatology. 2008;217(4):356-8; author reply 359 [18802351.001]
  • (PMID = 18182811.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Fontana-Masson stain; 0 / Melanins; 95IT3W8JZE / Silver Nitrate
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16. Palicka GA, Rhodes AR: Acral melanocytic nevi: prevalence and distribution of gross morphologic features in white and black adults. Arch Dermatol; 2010 Oct;146(10):1085-94
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  • [Title] Acral melanocytic nevi: prevalence and distribution of gross morphologic features in white and black adults.
  • OBJECTIVE: To determine prevalence and morphologic features of acral melanocytic nevi in white and black adults.
  • Diffusely black acral nevi were uncommon in whites (0 of 343) and blacks (1 of 119).
  • The prevalence of palmar or plantar nevi increased directly with degree of skin pigmentation (P < .001).
  • In whites, this prevalence was greater in women (27.1%, 51 of 188) than in men (18.1%, 28 of 155) (P = .047); in subjects younger than 50 years (30.8%, 57 of 185) than in those 50 years or older (13.9%, 22 of 158) (P < .001); in subjects with a history of atypical nevus removal than in those without (odds ratio [OR], 3.6; 95% confidence interval [CI], 1.9-6.9); in those with at least 1 extant atypical nevus than in those without (OR, 3.2; 95% CI, 1.7-6.0); and in those with at least 20 nevi of 2-mm diameter or larger than in those without (OR, 3.0; 95% CI, 1.6-5.6).
  • CONCLUSIONS: Acral nevi appear to be associated with ethnicity, pigmentation, age, and cutaneous melanoma (CM) risk factors.
  • While relatively large and/or very darkly pigmented acral nevi appear to be more common in blacks than in whites, diffusely black acral nevi are uncommon in both groups.
  • These findings are relevant to the assessment of pigmented lesions in the differential diagnosis of acral CM.
  • [MeSH-major] African Americans. European Continental Ancestry Group. Nevus, Pigmented / epidemiology. Nevus, Pigmented / pathology. Skin Neoplasms / epidemiology. Skin Neoplasms / pathology

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  • (PMID = 20956637.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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17. Altamura D, Altobelli E, Micantonio T, Piccolo D, Fargnoli MC, Peris K: Dermoscopic patterns of acral melanocytic nevi and melanomas in a white population in central Italy. Arch Dermatol; 2006 Sep;142(9):1123-8
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  • [Title] Dermoscopic patterns of acral melanocytic nevi and melanomas in a white population in central Italy.
  • OBJECTIVE: To investigate the dermoscopic features of acral melanocytic lesions in a white population in central Italy.
  • MAIN OUTCOME MEASURES: We retrospectively investigated all digital dermoscopic images of acral melanocytic lesions included in our database from January 1996 to May 2005.
  • RESULTS: We retrieved digital images of 723 benign acral melanocytic lesions in 641 patients (235 males and 406 females; mean age, 26.5 years) and of 10 acral melanomas in 10 patients (7 males and 3 females; mean age, 65 years).
  • Among acral nevi, the parallel furrow (42.1%) was the most common pattern, followed by the latticelike (14.9%), nontypical (13.7%), fibrillar (10.8%), homogeneous (9.3%), globular (5.4%), and reticular (2.1%) patterns.
  • Also, 13 acral nevi (1.8%), mainly located on the fingers, showed a new combined pattern (transition pattern) consisting of a brownish black network associated with a parallel furrow or latticelike pattern.
  • All 10 acral melanomas showed a multicomponent dermoscopic pattern.
  • CONCLUSIONS: In our series of acral nevi, we observed 8 dermoscopic patterns, with varying distribution by anatomical site.
  • Identification of a specific pattern is highly suggestive of the benign or the malignant nature of any given acral melanocytic lesion.
  • [MeSH-major] Dermoscopy / standards. Melanoma / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • [CommentIn] Arch Dermatol. 2006 Sep;142(9):1211-2 [16983009.001]
  • (PMID = 16982999.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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18. Nagore E, Pereda C, Botella-Estrada R, Requena C, Guillén C: Acral lentiginous melanoma presents distinct clinical profile with high cancer susceptibility. Cancer Causes Control; 2009 Feb;20(1):115-9
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  • [Title] Acral lentiginous melanoma presents distinct clinical profile with high cancer susceptibility.
  • BACKGROUND: Acral lentiginous melanoma (ALM) is a distinct histological variant of cutaneous melanoma that presents a genomic profile different from the other variants.
  • Among these, 79 were located on acral sites and 46 presented an ALM.
  • In comparison with the other frequent variants we have shown that ALM has some important differences which emphasize that it is a distinct entity more probably related to certain cancer susceptibility but unrelated to familial melanoma, tendency to developing nevus or sun exposure.
  • [MeSH-major] Melanoma / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 18758972.001).
  • [ISSN] 1573-7225
  • [Journal-full-title] Cancer causes & control : CCC
  • [ISO-abbreviation] Cancer Causes Control
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
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19. Khalifeh I, Taraif S, Reed JA, Lazar AF, Diwan AH, Prieto VG: A subgroup of melanocytic nevi on the distal lower extremity (ankle) shares features of acral nevi, dysplastic nevi, and melanoma in situ: a potential misdiagnosis of melanoma in situ. Am J Surg Pathol; 2007 Jul;31(7):1130-6
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  • [Title] A subgroup of melanocytic nevi on the distal lower extremity (ankle) shares features of acral nevi, dysplastic nevi, and melanoma in situ: a potential misdiagnosis of melanoma in situ.
  • Melanocytic lesions in certain locations (eg, genital, breast, acral) may have histologic and clinical features simulating melanoma.
  • This study highlights a group of melanocytic lesions located on the ankle that share histologic features with acral nevi, DN, and melanoma.
  • [MeSH-major] Diagnostic Errors / prevention & control. Dysplastic Nevus Syndrome / pathology. Hutchinson's Melanotic Freckle / pathology. Nevus, Pigmented / pathology. Precancerous Conditions / pathology. Skin Neoplasms / pathology

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  • (PMID = 17592281.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Melanins
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20. Panasiti V, Devirgiliis V, Borroni RG, Mancini M, Rossi M, Curzio M, Mastrecchia B, Bottoni U, Innocenzi D, Calvieri S: Dermoscopy of a plantar combined blue nevus: a simulator of melanoma. Dermatology; 2007;214(2):174-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dermoscopy of a plantar combined blue nevus: a simulator of melanoma.
  • Dermoscopy allows early detection of melanoma also on acral volar skin.
  • The histopathological examination revealed a combined blue nevus.
  • We present this case to underline that on acral volar skin also intradermal nevi, such as combined blue nevi, may dermoscopically exhibit a parallel ridge pattern, simulating melanoma.
  • [MeSH-major] Foot Diseases / pathology. Melanoma / pathology. Nevus, Blue / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Dermoscopy. Diagnosis, Differential. Female. Humans. Middle Aged. Skin / pathology

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  • [Copyright] Copyright 2007 S. Karger AG, Basel.
  • (PMID = 17341869.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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21. Togawa Y, Nakamura Y, Kamada N, Kambe N, Takahashi Y, Matsue H: Melanoma in association with acquired melanocytic nevus in Japan: a review of cases in the literature. Int J Dermatol; 2010 Dec;49(12):1362-7
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  • [Title] Melanoma in association with acquired melanocytic nevus in Japan: a review of cases in the literature.
  • In Japan, however, over half of all melanomas are acral lentiginous melanomas (ALMs) on the hands and feet; melanomas on sun-exposed areas are seen less frequently in Japanese people than in Caucasians.
  • METHODS: Here we report a case of a superficial spreading melanoma that was formed on a melanocytic nevus on the trunk, and we review for the first time the case reports from the Japanese literature.
  • [MeSH-major] Melanoma / complications. Melanoma / pathology. Nevus, Pigmented / complications. Skin Neoplasms / complications. Skin Neoplasms / pathology

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  • (PMID = 21155082.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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22. Motegi S, Nagai Y, Tamura A, Ishikawa O: Multiple skin cysts in nevoid basal cell carcinoma syndrome: a case report and review of the literature. Dermatology; 2008;216(2):159-62
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  • [Title] Multiple skin cysts in nevoid basal cell carcinoma syndrome: a case report and review of the literature.
  • We report a 72-year-old man with nevoid basal cell carcinoma syndrome (NBCCS) who presented with 25 skin cysts on his trunk and extremities.
  • Fourteen of 25 skin cysts (56%) were observed on his hands.
  • However, 4 skin cysts (4/16; 25%) showed a corrugated or festooned inner surface of wall without a granular cell layer, which resembled an odontogenic keratocyst, a characteristic feature of skin cysts in NBCCS.
  • A review of the literature suggested that acral localization of skin cysts is a distinctive feature of NBCCS.
  • In addition, the histological findings of skin cysts resembling an odontogenic keratocyst might be a hallmark of NBCCS.
  • [MeSH-major] Basal Cell Nevus Syndrome / complications. Cysts / complications. Skin Neoplasms / complications
  • [MeSH-minor] Aged. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Skin Diseases / complications. Skin Diseases / diagnosis


23. Massi G: Melanocytic nevi simulant of melanoma with medicolegal relevance. Virchows Arch; 2007 Sep;451(3):623-47
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  • The nevi are: hyper-cellular form of common nevus to be distinguished from nevoid melanoma, Spitz nevus (vs spitzoid melanoma), Reed nevus (vs melanoma with features of Reed nevus), cellular atypical blue nevus (vs melanoma on blue nevus), acral nevus (vs acral melanoma), Clark dysplastic nevus (vs superficial spreading melanoma), desmoplastic nevi (vs desmoplastic melanoma), benign proliferative nodules in congenital nevi (vs melanoma on congenital nevi), epithelioid blue nevus (vs animal type melanoma) and regressed nevus (vs regressed melanoma).
  • [MeSH-major] Liability, Legal. Melanoma / pathology. Nevus, Pigmented / pathology. Pathology / legislation & jurisprudence. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Child, Preschool. Diagnosis, Differential. Dysplastic Nevus Syndrome / pathology. Humans. Infant. Infant, Newborn. Neoplasms, Second Primary / pathology. Nevus / congenital. Nevus / pathology. Nevus, Blue / pathology. Nevus, Spindle Cell / pathology

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  • [CommentIn] Virchows Arch. 2008 Jan;452(1):113-4 [18026988.001]
  • (PMID = 17653760.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 161
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24. Lan CC, Yu HS, Wu CS, Chen GS: Immotile acral melanocytes? Br J Dermatol; 2006 Dec;155(6):1300-1
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  • [Title] Immotile acral melanocytes?
  • [MeSH-major] Melanocytes / pathology. Melanoma / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • (PMID = 17107411.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] England
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25. Schärer L: [Melanocytic nevi at special anatomical sites]. Pathologe; 2007 Nov;28(6):430-6
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  • Melanocytic nevi at special anatomical sites can evoke a histological picture easily leading to the false diagnosis of a highly atypical, dysplastic nevus or even malignant melanoma.
  • The anatomical regions recognized as "special sites" are the head and neck, especially the ear, the milk line (axilla, mamae, mamillae, umbilicus, groin), acral regions (palms and soles, knee, dorsum of the foot) and flexural sites.
  • [MeSH-major] Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • (PMID = 17874107.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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26. Miyazaki A, Saida T, Koga H, Oguchi S, Suzuki T, Tsuchida T: Anatomical and histopathological correlates of the dermoscopic patterns seen in melanocytic nevi on the sole: a retrospective study. J Am Acad Dermatol; 2005 Aug;53(2):230-6
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  • BACKGROUND: Anatomical and histopathologic correlates of the unique dermoscopic patterns seen in melanocytic nevi on acral volar skin is yet to be clarified.
  • RESULTS: Melanocytic nevi showing the parallel furrow pattern or the fibrillar pattern were located on the portions of the sole with regular parallel skin markings and were not found on the arch areas of the foot.
  • Histopathologically, irrespective of the dermoscopic patterns, nests of nevus cells were mainly located in the epidermal rete ridges underlying the surface sulci.
  • CONCLUSION: Dermoscopic patterns seen in acral melanocytic nevi could be explained by the unique anatomical and histopathological characteristics of the acral skin.
  • [MeSH-major] Dermoscopy. Foot Diseases / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • [CommentIn] J Am Acad Dermatol. 2006 Jul;55(1):162-3 [16781315.001]
  • (PMID = 16021115.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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27. Kogushi-Nishi H, Kawasaki J, Kageshita T, Ishihara T, Ihn H: The prevalence of melanocytic nevi on the soles in the Japanese population. J Am Acad Dermatol; 2009 May;60(5):767-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Acral lentiginous melanoma (ALM) is the most common type of melanoma in Japan.
  • The association between ALM and acral nevus has not been elucidated.
  • OBJECTIVE: To investigate the prevalence and dermatoscopic patterns of plantar melanocytic nevi on the soles in the Japanese and to evaluate the relationship between acral nevi and ALM.
  • [MeSH-major] Foot Diseases / epidemiology. Nevus, Pigmented / epidemiology. Skin Neoplasms / epidemiology

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  • (PMID = 19389519.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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28. Massi G, Vellone VG, Pagliarello C, Fabrizi G: Plantar melanoma that mimics melanocytic nevi: a report of 4 cases with lymph node metastases and with review of positive and negative controls. Am J Dermatopathol; 2009 Apr;31(2):117-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • One case showed inguinal lymph node metastases after a diagnosis of compound nevus made 5 years earlier.
  • The other 3 cases were sent to us in consultation as suspected plantar lesions; a diagnosis of melanoma mimicking compound nevus was proposed: the sentinel lymph node technique was accordingly performed and resulted positive.
  • Histologically, the similarity of areas of these 4 cases of plantar melanoma to compound plantar nevi (namely Miescher, Clark, or acral lentiginous nevus) is so close that it may prove misleading in the diagnostic pathway.
  • In fact, this deceptive form of melanoma mimicking a compound nevus is characterized by patients' advanced age (>45 years), large lateral diameters (>10 mm), and significant depth of the lesion (>1 mm).
  • [MeSH-major] Dermis / pathology. Melanoma / secondary. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • (PMID = 19318796.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Tanaka M: Dermoscopy. J Dermatol; 2006 Aug;33(8):513-7
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  • Acral melanocytic lesions have site-specific dermoscopic patterns, namely parallel furrow pattern or parallel ridge pattern.
  • Benign melanocytes (nevus cells) are mainly found on the tips of crista profunda limitans and supply melanin granules to the furrows of stratum corneum, making a parallel furrow pattern.
  • [MeSH-major] Dermoscopy. Melanoma / diagnosis. Nevus, Pigmented / pathology. Skin Neoplasms / diagnosis

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  • (PMID = 16923131.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 0
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30. Coras B, Landthaler M, Stolz W, Vogt T: Dysplastic melanocytic nevi of the lower leg: sex- and site-specific histopathology. Am J Dermatopathol; 2010 Aug;32(6):599-602
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  • Site-specific histopathology features have been reported for acral, auricular, flexural, and genital melanocytic nevi, however, to the best of our knowledge, site- and sex-specific histology of dysplastic nevi on the lower leg (between knee and ankle) of women (DN-LW) has not been reported.
  • DN-LW compared with DN-LM showed sex-specific differences with (1) pagetoid spread (P < 0.05), (2) cytologic atypia (P < 0.05), (3) presence of large melanocytes (P < 0.05), and (4) band-like pigmentation in the dermis underlying the nevus (54% in DN-LW vs. 15% in DN-LM).
  • [MeSH-major] Diagnostic Errors / prevention & control. Dysplastic Nevus Syndrome / diagnosis. Melanocytes / pathology. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis

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  • [CommentIn] Am J Dermatopathol. 2012 Dec;34(8):853-5 [22481498.001]
  • (PMID = 20534984.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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31. Hosler GA, Moresi JM, Barrett TL: Nevi with site-related atypia: a review of melanocytic nevi with atypical histologic features based on anatomic site. J Cutan Pathol; 2008 Oct;35(10):889-98
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  • We categorize these lesions into four main groups: acral, genital, special site and conjunctival, based on anatomy and relative prevalence of specific atypical histologic features.
  • [MeSH-major] Conjunctiva / pathology. Foot / pathology. Genitalia / pathology. Hand / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • (PMID = 18822061.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 39
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32. Gao HW, Yu CP, Lee HS, Nieh S, Chiang CP, Wang WM, Jin JS: Fascin, cortactin and survivin expression of melanocytic neoplasms and association with clinicopathological parameters and anatomic locations in Chinese people. Eur J Dermatol; 2010 May-Jun;20(3):293-301
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  • We collected 170 melanocytic lesions, including 106 cutaneous malignant melanoma (MM) from acral (AM) and non-acral (NAM) sites, 24 dysplastic nevi (DN), and 40 common melanocytic nevi (CMN).
  • The significantly different expression of immunoreactivities (nuclear survivin) between AM and NAM and the different mortality risks of melanomas on acral versus non-acral sites might change site-specific therapeutic concepts in melanoma.
  • [MeSH-major] Carrier Proteins / biosynthesis. Cortactin / biosynthesis. Microfilament Proteins / biosynthesis. Microtubule-Associated Proteins / biosynthesis. Nevus, Pigmented / metabolism. Skin / pathology. Skin Neoplasms / metabolism

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  • (PMID = 20400386.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Actins; 0 / BIRC5 protein, human; 0 / Carrier Proteins; 0 / Cortactin; 0 / Inhibitor of Apoptosis Proteins; 0 / Microfilament Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; 146808-54-0 / fascin
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33. Lazova R, Lester B, Glusac EJ, Handerson T, McNiff J: The characteristic histopathologic features of nevi on and around the ear. J Cutan Pathol; 2005 Jan;32(1):40-4
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  • BACKGROUND: Nevi on certain areas of the body such as the acral, genital, and flexural regions may exhibit uncommon but characteristic histopathologic features.
  • [MeSH-major] Ear Neoplasms / pathology. Nevus / pathology. Skin Neoplasms / pathology

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  • (PMID = 15660654.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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34. Selim MA, Vollmer RT, Herman CM, Pham TT, Turner JW: Melanocytic nevi with nonsurgical trauma: a histopathologic study. Am J Dermatopathol; 2007 Apr;29(2):134-6
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  • Nevi were present, in order of frequency, on the extremities, trunk, and head/neck, but there were no acral sites.
  • [MeSH-major] Nevus, Pigmented / pathology. Skin / injuries. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Dermatitis / pathology. Female. Fibrosis. Humans. Male. Middle Aged. Parakeratosis / pathology. Skin Ulcer / pathology. Telangiectasis / pathology

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  • (PMID = 17414433.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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35. Nagore E, Botella-Estrada R, Garcia-Casado Z, Requena C, Serra-Guillen C, Llombart B, Sanmartin O, Guillen C: Comparison between familial and sporadic cutaneous melanoma in Valencia, Spain. J Eur Acad Dermatol Venereol; 2008 Aug;22(8):931-6
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  • For this study the following variables were selected: age, sex, melanoma site and presence of solar lentigines on the melanoma surrounding skin, histological subtype, tumor thickness, stage, family and personal history of cutaneous melanoma and of other neoplasias, personal history of non-melanoma skin cancer, past personal history of severe sunburns, cutaneous phenotype (phototype, hair and eyes colors number of common nevus, number of atypical nevi, presence of solar lentigines).
  • Among the multiple variables studied, a younger age at diagnosis (median age of 42 vs 53 years), higher frequency of the presence of at least one clinically atypical nevus (36.1% vs 17.7%), multiple melanomas (12.2% vs 3.4%) and red/blonde hair (33.3% vs 18.9%), and a lower rate of cases with solar lentigines in melanoma site (33.3% vs 56.3%) were found for familial cases.
  • Interestingly, no acral melanomas were found among the familial cases.
  • [MeSH-major] Melanoma / genetics. Melanoma / pathology. Skin Neoplasms / genetics. Skin Neoplasms / pathology

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  • (PMID = 18355200.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
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36. Kolm I, Puig S, Iranzo P, Malvehy J: Dermoscopy in Gorlin-Goltz syndrome. Dermatol Surg; 2006 Jun;32(6):847-51
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  • Acral pits that are often overlooked during physical examination have a characteristic dermoscopy with red globules that are mainly distributed in parallel lines inside flesh-colored, irregular-shaped, and slightly depressed lesions.
  • [MeSH-major] Basal Cell Nevus Syndrome / pathology. Dermoscopy. Skin Neoplasms / pathology

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  • (PMID = 16792654.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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37. Tan KB, Moncrieff M, Thompson JF, McCarthy SW, Shaw HM, Quinn MJ, Li LX, Crotty KA, Stretch JR, Scolyer RA: Subungual melanoma: a study of 124 cases highlighting features of early lesions, potential pitfalls in diagnosis, and guidelines for histologic reporting. Am J Surg Pathol; 2007 Dec;31(12):1902-12
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  • The features of 28 cases of subungual melanoma in situ (MIS), comprising 4 cases of MIS and 24 cases where areas of MIS were present adjacent to dermal-invasive SUMs, were compared with those of a similar number of acral nevi to identify useful distinguishing features.
  • The commonest histogenetic subtype was acral lentiginous (66%), followed by nodular (25%) and desmoplastic (7%).
  • In comparison to acral nevi, MIS more frequently showed lack of circumscription, a prominent lentiginous growth pattern, predominance of single cells over nests, moderate-to-severe cytologic atypia, a dense and haphazard pagetoid intraepidermal spread of melanocytes, and the presence of junctional/subjunctional lymphocytes ("tumor infiltrating lymphocytes").
  • [MeSH-major] Melanoma / pathology. Nail Diseases / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Diagnosis, Differential. Female. Fingers / pathology. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Staging. Nevus, Pigmented / metabolism. Nevus, Pigmented / pathology. Sentinel Lymph Node Biopsy. Survival Rate. Toes / pathology

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  • (PMID = 18043047.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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38. Demirkan NC, Kesen Z, Akdag B, Larue L, Delmas V: The effect of the sun on expression of beta-catenin, p16 and cyclin d1 proteins in melanocytic lesions. Clin Exp Dermatol; 2007 Nov;32(6):733-9
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  • METHODS: We used immunohistochemistry to examine 28 melanocytic naevi (MN; 9 congenital and 19 acquired types) and 24 primary cutaneous malignant melanomas (CMM; 19 nodular melanomas, 3 lentigo maligna melanomas, 1 acral lentiginous melanoma and 1 superficial spreading melanoma) for the presence of p16, cyclin D1 and beta-catenin.
  • [MeSH-major] Cell Cycle Proteins / biosynthesis. Melanoma / metabolism. Neoplasm Proteins / biosynthesis. Nevus, Pigmented / metabolism. Skin Neoplasms / metabolism. Sunlight

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  • (PMID = 17868395.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Neoplasm Proteins; 0 / beta Catenin; 136601-57-5 / Cyclin D1
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39. Aguilera P, Puig S, Guilabert A, Julià M, Romero D, Vicente A, González-Enseñat MA, Malvehy J: Prevalence study of nevi in children from Barcelona. Dermoscopy, constitutional and environmental factors. Dermatology; 2009;218(3):203-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We found that 61.1% of children had nevi on the face and neck, 17.2% on the buttocks, 11.7% on the scalp, 19.4% had acral nevi and 31.7% had congenital nevi.
  • [MeSH-major] Nevus / epidemiology. Skin Neoplasms / epidemiology
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Dermoscopy. Female. Humans. Infant. Male. Neoplasms, Radiation-Induced / epidemiology. Neoplasms, Radiation-Induced / pathology. Nevus, Pigmented / epidemiology. Nevus, Pigmented / etiology. Nevus, Pigmented / pathology. Pigmentation. Prevalence. Spain / epidemiology. Sunburn / complications. Sunlight / adverse effects

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  • [Copyright] 2008 S. Karger AG, Basel
  • [CommentIn] Dermatology. 2010;220(1):53; author reply 54 [19776540.001]
  • (PMID = 19060476.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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40. Forman SB, Ferringer TC, Peckham SJ, Dalton SR, Sasaki GT, Libow LF, Elston DM: Is superficial spreading melanoma still the most common form of malignant melanoma? J Am Acad Dermatol; 2008 Jun;58(6):1013-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Nodular melanoma with no apparent radial growth phase accounted for 27 cases (4%), and there were 23 cases of acral lentiginous melanoma (3%).
  • The remaining 72 specimens (9%) included cutaneous metastases, spitzoid melanoma, melanoma in situ arising within a nevus, nevoid melanoma, desmoplastic melanoma, and patterns that could not be classified.
  • We were not able to perform subgroup analysis based on ethnicity or skin type as such data were not typically submitted with the specimens.
  • [MeSH-major] Melanoma / epidemiology. Melanoma / pathology. Skin Neoplasms / epidemiology. Skin Neoplasms / pathology

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  • [CommentIn] J Am Acad Dermatol. 2008 Jun;58(6):1059-60 [18485988.001]
  • [CommentIn] J Am Acad Dermatol. 2009 May;60(5):876 [19389532.001]
  • [ErratumIn] J Am Acad Dermatol. 2009 Sep;61(3):507
  • (PMID = 18485983.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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41. Takata M, Lin J, Takayanagi S, Suzuki T, Ansai S, Kimura T, Cerroni L, Saida T: Genetic and epigenetic alterations in the differential diagnosis of malignant melanoma and spitzoid lesion. Br J Dermatol; 2007 Jun;156(6):1287-94
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  • RESULTS: Twenty three of 24 conventional melanomas showed at least one of the genetic and epigenetic alterations examined, although one acral melanoma did not show any alteration.
  • [MeSH-major] Melanoma / diagnosis. Mutation / genetics. Nevus, Epithelioid and Spindle Cell / diagnosis. Skin Neoplasms / diagnosis


42. Richards HW, Medrano EE: Epigenetic marks in melanoma. Pigment Cell Melanoma Res; 2009 Feb;22(1):14-29
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  • Melanoma is a highly heterogeneous cancer that comes in different flavors (lentigo maligna melanoma, superficial spreading melanoma, nodular melanoma, acral lentiginous/mucosal melanoma and other less common subtypes including malignant cellular blue nevus, desmoplastic melanoma, nevoid melanoma, and animal-type melanoma) and colors (black/bluish or unpigmented).
  • Here, we review the current data on epigenetic research in melanoma skin cancers, discuss ways to modify the epigenetic landscape of melanoma for inhibiting its growth, and propose strategies for identifying novel melanoma markers.

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  • [ErratumIn] Pigment Cell Melanoma Res. 2009 Apr;22(2):242
  • (PMID = 19040501.001).
  • [ISSN] 1755-1471
  • [Journal-full-title] Pigment cell & melanoma research
  • [ISO-abbreviation] Pigment Cell Melanoma Res
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 2R01 CA84282; United States / NIA NIH HHS / AG / R01 AG032135
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 160
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43. Saida T, Koga H: Dermoscopic patterns of acral melanocytic nevi: their variations, changes, and significance. Arch Dermatol; 2007 Nov;143(11):1423-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dermoscopic patterns of acral melanocytic nevi: their variations, changes, and significance.
  • [MeSH-major] Dermoscopy. Extremities. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis

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  • [CommentOn] Arch Dermatol. 2007 Nov;143(11):1378-84 [18025361.001]
  • [CommentOn] Arch Dermatol. 2007 Nov;143(11):1372-6 [18025360.001]
  • (PMID = 18025367.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Comment; Editorial; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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44. Palleschi GM, Urso C, Torre E, Torchia D: Histopathological correlates of the parallel-furrow pattern seen in acral melanocytic nevi at dermatoscopy. Dermatology; 2008;217(4):356-8; author reply 359
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histopathological correlates of the parallel-furrow pattern seen in acral melanocytic nevi at dermatoscopy.
  • [MeSH-major] Dermoscopy. Foot. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • [CommentOn] Dermatology. 2008;216(3):205-12 [18182811.001]
  • (PMID = 18802351.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] Switzerland
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45. Bowling J: Fibrillar pattern of an acquired plantar acral melanocytic naevus: correspondence between epiluminescence light microscopy and transverse section histology. Clin Exp Dermatol; 2007 Jan;32(1):103
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fibrillar pattern of an acquired plantar acral melanocytic naevus: correspondence between epiluminescence light microscopy and transverse section histology.
  • [MeSH-major] Foot Diseases / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • [CommentOn] Clin Exp Dermatol. 2006 May;31(3):449-51 [16681598.001]
  • (PMID = 16939585.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] England
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