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1. Lin J, Takata M, Murata H, Goto Y, Kido K, Ferrone S, Saida T: Polyclonality of BRAF mutations in acquired melanocytic nevi. J Natl Cancer Inst; 2009 Oct 21;101(20):1423-7
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  • [Title] Polyclonality of BRAF mutations in acquired melanocytic nevi.
  • Melanocytic nevi are thought to be senescent clones of melanocytes that have acquired an oncogenic BRAF mutation.
  • However, using immunomagnetic separation or laser-capture microdissection, we examined BRAF mutations in sets of approximately 50 single cells isolated from acquired melanocytic nevi from 13 patients and found a substantial number of nevus cells that contained wild-type BRAF mixed with nevus cells that contained BRAF(V600E).
  • Furthermore, we simultaneously amplified BRAF exon 15 and a neighboring single nucleotide polymorphism (SNP), rs7801086, from nevus cell samples obtained from four patients who were heterozygous for this SNP.
  • The polyclonality of BRAF mutations in acquired melanocytic nevi suggests that mutation of BRAF may not be an initial event in melanocyte transformation.

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  • (PMID = 19752400.001).
  • [ISSN] 1460-2105
  • [Journal-full-title] Journal of the National Cancer Institute
  • [ISO-abbreviation] J. Natl. Cancer Inst.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA105500
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 3KX376GY7L / Glutamic Acid; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; HG18B9YRS7 / Valine
  • [Other-IDs] NLM/ PMC2765260
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2. Fullen DR, Poynter JN, Lowe L, Su LD, Elder JT, Nair RP, Johnson TM, Gruber SB: BRAF and NRAS mutations in spitzoid melanocytic lesions. Mod Pathol; 2006 Oct;19(10):1324-32
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  • [Title] BRAF and NRAS mutations in spitzoid melanocytic lesions.
  • BRAF mutations are common events in a variety of melanocytic nevi and primary cutaneous melanomas.
  • We have previously found BRAF mutations in 82% of nevi, consisting of congenital, common acquired and dysplastic types, and 33% of primary cutaneous melanomas other than the spitzoid type, similar to other published reports.
  • Only one study included categories of atypical Spitz nevus and borderline lesions suspected to be spitzoid melanomas, along with classic Spitz nevi and spitzoid melanomas.
  • Five of the 10 Spitz nevi with BRAF mutations were altered by more than usual cytologic atypia and/or architectural atypia overlapping with dysplastic nevi, or irritation/inflammation; one desmoplastic Spitz nevus had a BRAF mutation.
  • Therefore, the BRAF mutational status does not separate all Spitz nevi from spitzoid melanomas and non-Spitz types of melanocytic proliferations, contrary to previous reports.
  • [MeSH-major] Melanoma / genetics. Mutation. Nevus, Epithelioid and Spindle Cell / genetics. Proto-Oncogene Proteins B-raf / genetics. Proto-Oncogene Proteins p21(ras) / genetics. Skin Neoplasms / genetics

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  • (PMID = 16799476.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Grant] United States / NHGRI NIH HHS / HG / T32 HG00040; United States / NCI NIH HHS / CA / U01 CA83180
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras)
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3. Zemelman D V, Molina C P, Valenzuela CY, Honeyman M J: [Body distribution and density of acquired melanocytic nevi in adolescents of low socioeconomic status of Santiago, Chile]. Rev Med Chil; 2008 Jun;136(6):747-52
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  • [Title] [Body distribution and density of acquired melanocytic nevi in adolescents of low socioeconomic status of Santiago, Chile].
  • Previous studies have shown that the density and size of acquired melanocytic nevi (AMN) are a risk factor for developing malignant melanoma.
  • AIM: To assess the number and anatomical distribution of acquired melanocytic nevi in Chilean adolescents.
  • [MeSH-major] Melanoma / epidemiology. Neoplasms, Radiation-Induced / epidemiology. Nevus, Pigmented / pathology. Poverty. Skin Neoplasms / epidemiology


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4. Hashimoto Y, Ito Y, Kato T, Motokawa T, Katagiri T, Itoh M: Expression profiles of melanogenesis-related genes and proteins in acquired melanocytic nevus. J Cutan Pathol; 2006 Mar;33(3):207-15
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  • [Title] Expression profiles of melanogenesis-related genes and proteins in acquired melanocytic nevus.
  • CONCLUSIONS: Our results suggest that all nevus cells that constitute AMN tissue originate from melanocytes.
  • Further, there may be differences in the transcription levels of melanogenesis-related genes as well as in their post-transcriptional regulation between nevus cells located in the basal epidermal to upper dermis layer and those in the lower dermis layer.
  • [MeSH-major] Gene Expression Regulation, Neoplastic. Genes, Neoplasm. Neoplasm Proteins / genetics. Nevus, Pigmented / genetics. Skin Neoplasms / genetics

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  • (PMID = 16466507.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MITF protein, human; 0 / Membrane Glycoproteins; 0 / Microphthalmia-Associated Transcription Factor; 0 / Neoplasm Proteins; 0 / PMEL protein, human; 0 / Proteins; 0 / RNA, Messenger; 0 / gp100 Melanoma Antigen; EC 1.- / Oxidoreductases; EC 1.14.18.- / TYRP1 protein, human; EC 5.3.- / Intramolecular Oxidoreductases; EC 5.3.3.12 / dopachrome isomerase
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5. Fullen DR, Zhu W, Thomas D, Su LD: hTERT expression in melanocytic lesions: an immunohistochemical study on paraffin-embedded tissue. J Cutan Pathol; 2005 Nov;32(10):680-4
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  • [Title] hTERT expression in melanocytic lesions: an immunohistochemical study on paraffin-embedded tissue.
  • The aim of this study was to evaluate human telomerase reverse transcriptase (hTERT) staining in melanocytic lesions on paraffin-embedded tissues.
  • METHODS: Paraffin-embedded sections from 12 acquired nevi, seven dysplastic nevi, 11 Spitz nevi, eight primary invasive melanomas, and three metastatic melanomas were studied for staining intensity (0-3+) and percentage of labeled cells with anti-hTERT.
  • Spitz nevi tended to have weaker hTERT staining (mean = 1.7) compared with acquired nevi (mean = 2.2), dysplastic nevi (mean = 2.4), primary melanomas (mean = 2.4), or metastatic melanomas (mean = 3).
  • Thus, hTERT expression does not appear to be a reliable adjunct to the histological diagnosis of primary melanocytic lesions.
  • [MeSH-major] DNA-Binding Proteins / analysis. Melanocytes / enzymology. Melanoma / enzymology. Nevus / chemistry. Nevus, Epithelioid and Spindle Cell / enzymology. Nevus, Pigmented / enzymology. Telomerase / analysis
  • [MeSH-minor] Cell Nucleus / chemistry. Diagnosis, Differential. Dysplastic Nevus Syndrome / diagnosis. Dysplastic Nevus Syndrome / enzymology. Dysplastic Nevus Syndrome / pathology. Humans. Immunohistochemistry. Paraffin Embedding. Reproducibility of Results. Skin / enzymology. Skin / pathology

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  • (PMID = 16293180.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; EC 2.7.7.49 / Telomerase
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6. Kiyohara T, Kouraba S, Takahashi H, Kawasaki T, Takeuchi A, Kumakiri M: Malignant melanoma with preserved hairs: a snap shot could suggest the development from an acquired melanocytic nevus. J Dermatol; 2010 Feb;37(2):167-70
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  • [Title] Malignant melanoma with preserved hairs: a snap shot could suggest the development from an acquired melanocytic nevus.
  • Partially, there were well-circumscribed, oval nests composed of nevus cells in the acanthotic epidermis and follicles.
  • Nevus cells were also seen in the dermal component, presenting a burnt-out appearance.
  • In this case, the small final size, the preserved hairs and the snap shot suggested a preceding, acquired melanocytic nevus.
  • Malignant melanoma could arise from acquired melanocytic nevus.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Melanoma / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • (PMID = 20175852.001).
  • [ISSN] 1346-8138
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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7. Pellacani G, Cesinaro AM, Seidenari S: In vivo assessment of melanocytic nests in nevi and melanomas by reflectance confocal microscopy. Mod Pathol; 2005 Apr;18(4):469-74
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  • [Title] In vivo assessment of melanocytic nests in nevi and melanomas by reflectance confocal microscopy.
  • The aim of this study was to describe and characterize the cytological and architectural aspects of cell clusters in melanocytic lesions observed by confocal microscopy, and to correlate them with routine histopathology.
  • A total of 55 melanocytic lesions comprising 20 melanomas, 25 acquired nevi and 10 Spitz nevi were studied by means of reflectance confocal microscopy, dermoscopy and routine histopathology.
  • Sparse cell clusters were more frequently observable in melanomas, but also sporadically present in one Spitz nevus.
  • Confocal microscopy allowed the in vivo characterization of aspects of melanocytic nests and their exact correlation with histopathology.
  • [MeSH-major] Melanocytes / pathology. Melanoma / pathology. Microscopy, Confocal / methods. Nevus / pathology. Skin Neoplasms / pathology

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  • (PMID = 15529179.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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8. Fernandez-Flores A: Plasma cell infiltrate in common acquired melanocytic nevus. Acta Dermatovenerol Croat; 2008;16(3):158-63
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  • [Title] Plasma cell infiltrate in common acquired melanocytic nevus.
  • The presence of plasma cells in melanocytic lesions has been considered in literature as a sign of concern, when evaluated in the appropriate context.
  • Plasma cells have been evaluated in halo nevus, but they are not frequently reported in non-halo common acquired nevus.
  • No relation between the amount of plasma cells and either the location of the nevus or the location of the inflammatory infiltrate could be established.
  • We conclude that the main point of this study is not to trust the presence of plasma cells as a solid criterion on its own, when evaluating a melanocytic lesion.
  • [MeSH-major] Nevus, Pigmented / pathology. Plasma Cells / pathology

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  • (PMID = 18812067.001).
  • [ISSN] 1330-027X
  • [Journal-full-title] Acta dermatovenerologica Croatica : ADC
  • [ISO-abbreviation] Acta Dermatovenerol Croat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Croatia
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9. Togawa Y, Nakamura Y, Kamada N, Kambe N, Takahashi Y, Matsue H: Melanoma in association with acquired melanocytic nevus in Japan: a review of cases in the literature. Int J Dermatol; 2010 Dec;49(12):1362-7
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  • [Title] Melanoma in association with acquired melanocytic nevus in Japan: a review of cases in the literature.
  • BACKGROUND: Malignant melanomas clinically and/or histologically associated with melanocytic nevi have been reported worldwide.
  • Approximately 20% of malignant melanomas in Caucasians, most of which are found on the trunk and proximal extremities, develop in association with pre-existing melanocytic nevi.
  • As ALMs are not usually accompanied by melanocytic nevi and there have been no reviews of the literature or statistical data regarding Japanese cases of melanomas with melanocytic nevi, dermatologists in Japan have few opportunities to see melanomas associated with pre-existing melanocytic nevi.
  • METHODS: Here we report a case of a superficial spreading melanoma that was formed on a melanocytic nevus on the trunk, and we review for the first time the case reports from the Japanese literature.
  • RESULTS AND CONCLUSIONS: With regard to the reported cases, melanomas associated with melanocytic nevi were mainly superficial spreading melanomas and nodular melanomas on the trunk or extremities; ALMs were rarely associated with nevi, indicating a trend similar to that observed in Caucasians.
  • These findings suggest that the low frequency of associations between melanomas and melanocytic nevi in Japan reflects racial differences in the frequencies of each type of melanoma.
  • [MeSH-major] Melanoma / complications. Melanoma / pathology. Nevus, Pigmented / complications. Skin Neoplasms / complications. Skin Neoplasms / pathology

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  • (PMID = 21155082.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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10. Tanioka M, Kore-Eda S, Utani A, Miyachi Y, Tanaka M: Agminated acquired melanocytic nevus on the sole: clinical, dermoscopic and histopathological correlation. Eur J Dermatol; 2007 Mar-Apr;17(2):174-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Agminated acquired melanocytic nevus on the sole: clinical, dermoscopic and histopathological correlation.
  • [MeSH-major] Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 17337414.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] France
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11. Pizzichetta MA, Massone C, Grandi G, Pelizzo G, Soyer HP: Morphologic changes of acquired melanocytic nevi with eccentric foci of hyperpigmentation ("Bolognia sign") assessed by dermoscopy. Arch Dermatol; 2006 Apr;142(4):479-83
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  • [Title] Morphologic changes of acquired melanocytic nevi with eccentric foci of hyperpigmentation ("Bolognia sign") assessed by dermoscopy.
  • BACKGROUND: Melanocytic nevi with eccentric foci of hyperpigmentation ("Bolognia sign") can be considered as a melanoma-simulating type of acquired melanocytic nevus.
  • We report on the morphologic changes of this type of melanocytic nevus over a 39-month period of dermoscopic follow-up.
  • After 39 months, a globular type of acquired melanocytic nevus was detectable, which clinically and dermoscopically appeared to be completely benign.
  • A nearly identical situation was observed in 5 other melanocytic nevi, underlining the involution of the pigmented foci in these nevi.
  • The histopathologic diagnoses of 2 lesions were consistent with a compound type of acquired melanocytic nevus with eccentric foci of hyperpigmentation.
  • CONCLUSIONS: Dermoscopy allows identification of a morphologic pathway of modifications, probably typical for this type of melanocytic nevus in children, and therefore enables avoidance of surgical excision with attendant hypertrophic scarring in children.
  • Conversely, in adults, when dermoscopic follow-up of melanocytic nevi reveals eccentric foci of hyperpigmentation, surgical excision of the lesion is indicated.
  • [MeSH-major] Hyperpigmentation / diagnosis. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis

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  • [CommentOn] Arch Dermatol. 2006 Apr;142(4):508 [16618873.001]
  • (PMID = 16618868.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Journal Article
  • [Publication-country] United States
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12. Ishihara Y, Saida T, Miyazaki A, Koga H, Taniguchi A, Tsuchida T, Toyama M, Ohara K: Early acral melanoma in situ: correlation between the parallel ridge pattern on dermoscopy and microscopic features. Am J Dermatopathol; 2006 Feb;28(1):21-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Early melanomas of this anatomic site are often misdiagnosed as melanocytic nevi, which are not uncommon on acral skin.
  • In fact, clinical and/or histopathological features of melanocytic nevi occasionally mimic those of early acral melanoma and vice versa, and thus differentiation of early acral melanoma from melanocytic nevus is sometimes very difficult for clinicians as well as for histopathologists.
  • In the present study, we reviewed 22 acral melanocytic lesions that showed the parallel ridge pattern on dermoscopy but had very subtle clinical and/or histopathological presentations.
  • We diagnosed 20 of them as early melanoma in situ by careful histopathological examination, which revealed histopathological features very similar to those seen in macular portions of overt acral melanoma, but fundamentally different from features found in melanocytic nevi on acral skin.
  • The two remaining lesions were diagnosed as possible cases of acquired melanocytic nevus because of the formation of well-demarcated nests of melanocytes in the epidermal rete ridges.

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  • (PMID = 16456320.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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13. Tomasini C, Broganelli P, Pippione M: Targetoid hemosiderotic nevus. A trauma-induced simulator of malignant melanoma. Dermatology; 2005;210(3):200-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Targetoid hemosiderotic nevus. A trauma-induced simulator of malignant melanoma.
  • BACKGROUND: Simulators of malignant melanoma comprise a heterogenous group of melanocytic and nonmelanocytic lesions of the skin.
  • Among frequent clinical mimickers of melanoma are injured melanocytic nevi.
  • Any change in the clinical appearance of a pre-existing nevus should alert the clinician to exclude the possibility of malignant transformation in order to early identify a lesion at a stage when complete cure can still be achieved.
  • OBJECTIVE: The purpose of this study was to present the clinical, dermoscopic and histopathologic findings of a series of acquired melanocytic nevi which abruptly developed a pigmented peripheral halo, presumably following minor trauma.
  • METHODS: A series of 6 cases of acquired melanocytic nevi which suddenly developed a targetoid halo were included in the study.
  • The sudden development of an asymptomatic, targetoid halo on a long-lasting, acquired exophytic nevus was the main presentation.
  • Whereas the central nevus persisted, the ecchymotic halo ultimately disappeared.
  • Histopathologic examination disclosed changes of the traumatized nevus in the central part, whereas the ring showed hemorrhage and hemosiderin deposits.
  • CONCLUSIONS: Targetoid hemosiderotic nevus is a distinctive clinicopathologic variant of traumatized acquired melanocytic nevus which should be included in the list of clinical simulators of melanoma.
  • [MeSH-major] Nevus, Pigmented / diagnosis. Skin / injuries. Skin Neoplasms / diagnosis

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  • (PMID = 15785047.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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14. Requena C, Requena L, Kutzner H, Sánchez Yus E: Spitz nevus: a clinicopathological study of 349 cases. Am J Dermatopathol; 2009 Apr;31(2):107-16
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  • [Title] Spitz nevus: a clinicopathological study of 349 cases.
  • Spitz nevus is an infrequent, usually acquired melanocytic nevus composed of epithelioid and/or spindle melanocytes that can occasionally be confused with melanoma.
  • Currently, there are no immunohistochemical markers or molecular biology techniques that can be used to make an entirely safe diagnosis of Spitz nevus or melanoma in problematic cases.
  • A retrospective study has been carried out that included all the cases diagnosed as Spitz nevus from our files.
  • Spitz nevus was most commonly located on the lower extremities, followed by the trunk in both children and adults.
  • [MeSH-major] Nevus, Epithelioid and Spindle Cell / pathology. Skin / pathology. Skin Neoplasms / pathology


15. Yus ES, del Cerro M, Simón RS, Herrera M, Rueda M: Unna's and Miescher's nevi: two different types of intradermal nevus: hypothesis concerning their histogenesis. Am J Dermatopathol; 2007 Apr;29(2):141-51
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  • [Title] Unna's and Miescher's nevi: two different types of intradermal nevus: hypothesis concerning their histogenesis.
  • In 1991, we tentatively introduced the classification of Ackerman and Magana-García for acquired melanocytic nevi in our laboratory.
  • We soon realized that every acquired intradermal melanocytic nevus might be easily classified into either Unna's or Miescher's patterns and that this classification had both clinical implications and significant histological differences.
  • The decisive discriminative feature between Unna's and Miescher's nevi is that Unna's nevus is an almost purely adventitial lesion confined to expanded papillary dermis and, many times, to the perifollicular dermis too.
  • In Miescher's nevus melanocytes diffusely infiltrate both adventitial and reticular dermis in a wedge-shaped pattern.
  • With these concepts in mind, every acquired intradermal melanocytic nevus can be easily classified as either Unna's or Miescher's.
  • We studied 751 acquired melanocytic nevi; 458 (61%) of them were intradermal; of these, 234 were Unna's nevi and 224 were Miescher's nevi.
  • Only on the scalp was there no clear predominance of one type of intradermal nevus.
  • Unna's nevi had more: junctional nests above the intradermal component (40% versus 20%), a radial pattern of intradermal nests (38% versus 0%), vascular-like clefts lined by nevus cells (48% versus 4%), and in depth maturation (94% versus 0%).
  • Miescher's nevi had more: pilosebaceous follicles within the nevus (100% versus 51%), subnevis folliculitis (12% versus 1%), large isolated melanocytes along the basal epidermal layer (47% versus 11%), multinucleated nevocytes (89% versus 44%), and adipocytes within the nevus (53% versus 11%).
  • In conclusion, Unna's and Miescher's nevi are 2 subsets of acquired melanocytic nevus with clinical implications and significant histological differences.
  • [MeSH-major] Nevus, Intradermal / pathology. Nevus, Pigmented / pathology. Skin / pathology. Skin Neoplasms / pathology

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  • (PMID = 17414435.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Lebeau S, Braun RP, Masouyé I, Perrinaud A, Harms M, Borradori L: Acquired melanocytic naevus in childhood vulval pemphigoid. Dermatology; 2006;213(2):159-62
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  • [Title] Acquired melanocytic naevus in childhood vulval pemphigoid.
  • BACKGROUND: Eruptive epidermolysis bullosa (EB) naevi comprise a subset of melanocytic naevi with atypical features that characteristically occur in areas of former blistering in patients suffering from hereditary EB.
  • In the course of the disease, she developed an atypical melanocytic naevus on the left labium at a site of former blistering.
  • CONCLUSION: This is the first report describing the development of a melanocytic naevus at sites of blistering in an auto-immune subepidermal blistering disease in childhood.
  • Our observation extends the spectrum of disorders, in addition to the group of congenital EB, in which 'eruptive' atypical melanocytic naevi may occur.
  • [MeSH-major] Nevus, Pigmented / complications. Pemphigoid, Bullous / complications. Skin Neoplasms / complications. Vulvar Diseases / complications

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  • [Copyright] Copyright 2006 S. Karger AG, Basel.
  • (PMID = 16902297.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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17. Morales-Callaghan AM, Castrodeza-Sanz J, Martínez-García G, Peral-Martínez I, Miranda-Romero A: [Correlation between clinical, dermatoscopic, and histopathologic variables in atypical melanocytic nevi]. Actas Dermosifiliogr; 2008 Jun;99(5):380-9
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  • [Title] [Correlation between clinical, dermatoscopic, and histopathologic variables in atypical melanocytic nevi].
  • [Transliterated title] Estudio de correlación clínica, dermatoscópica e histopatológica de nevus melanocíticos atípicos.
  • INTRODUCTION: Atypical melanocytic nevi are acquired melanocytic lesions that were described for the first time by Clark in studies of melanocytic nevi in patients with melanomas.
  • Today, the use of dermatoscopy has made identification of this type of nevus much easier.
  • OBJECTIVE: Our aim was to study the correlation between the clinical, dermatoscopic, and histopathologic findings of melanocytic nevi and compare our findings with those of previous studies.
  • We also aimed to investigate the value of dermatoscopy for identifying atypical melanocytic nevi.
  • MATERIAL AND METHODS: In this cross-sectional, observational study, 200 melanocytic lesions were analyzed in 166 patients examined between January 1, 2005 and December 31, 2005.
  • We then determined the agreement between diagnoses and assessed the value of dermatoscopy for identifying atypical melanocytic melanoma.
  • Dermatoscopy improved the accuracy of clinical diagnosis of atypical melanocytic nevus.
  • [MeSH-major] Dermoscopy. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • [CommentIn] Actas Dermosifiliogr. 2009 Apr;100(3):249; author reply 249-50 [19457320.001]
  • (PMID = 18501170.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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18. Palleschi GM, Cipollini EM, Torchia D, Torre E, Urso C: Fibrillar pattern of a plantar acquired melanocytic naevus: correspondence between epiluminescence microscopy and transverse section histology. Clin Exp Dermatol; 2006 May;31(3):449-51
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  • [Title] Fibrillar pattern of a plantar acquired melanocytic naevus: correspondence between epiluminescence microscopy and transverse section histology.
  • The main epiluminescence microscopy (ELM) patterns observed on volar acquired melanocytic naevi are the parallel-furrow, the lattice-like and the fibrillar patterns.
  • To clarify the microscopic features of the fibrillar pattern, we used transverse histological sectioning to study an acquired compound melanocytic naevus of the sole, characterized by a mixed parallel-furrow/fibrillar pattern on ELM.
  • [MeSH-major] Foot Diseases / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • [CommentIn] Clin Exp Dermatol. 2007 Jan;32(1):103 [16939585.001]
  • (PMID = 16681598.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] England
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19. Zalaudek I, Zanchini R, Petrillo G, Ruocco E, Soyer HP, Argenziano G: Dermoscopy of an acral congenital melanocytic nevus. Pediatr Dermatol; 2005 May-Jun;22(3):188-91
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  • [Title] Dermoscopy of an acral congenital melanocytic nevus.
  • Congenital melanocytic nevi carry a risk for malignant transformation into melanoma, therefore early detection of suspicious features is crucial to reduce mortality rates.
  • Dermoscopically, congenital melanocytic nevi are often characterized by the presence of a cobblestone pattern, but to date, little is known about the dermoscopic features of acral congenital melanocytic nevi.
  • We report an acral congenital melanocytic nevus typified by the presence of three different dermoscopic patterns that are commonly seen in acquired melanocytic nevi of palms and soles.
  • [MeSH-major] Dermoscopy. Melanoma / congenital. Nevus, Pigmented / congenital. Skin Neoplasms / congenital

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  • (PMID = 15916562.001).
  • [ISSN] 0736-8046
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Yarak S, Ogawa MM, Hirata S, de Almeida FA: Prevalence of acquired melanocytic naevi in Brazilian schoolchildren. Clin Exp Dermatol; 2010 Aug;35(6):581-7
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  • [Title] Prevalence of acquired melanocytic naevi in Brazilian schoolchildren.
  • BACKGROUND: The prevalence of acquired melanocytic naevi (AMN) is one of the most important known risk factors for malignant melanoma (MM) in homogeneous white populations.
  • [MeSH-major] Melanoma / epidemiology. Nevus, Pigmented / epidemiology. Skin Neoplasms / epidemiology. Sunlight / adverse effects

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  • (PMID = 19874377.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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21. Vaidya DC, Schwartz RA, Janniger CK: Nevus spilus. Cutis; 2007 Dec;80(6):465-8
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  • [Title] Nevus spilus.
  • Nevus spilus (NS), also known as speckled lentiginous nevus (SLN), is a relatively common cutaneous lesion that is characterized by multiple pigmented macules or papules within a pigmented patch.
  • It may be congenital or acquired; however, its etiology remains unknown.
  • NS deserves its own place in the spectrum of classification of important melanocytic nevi; as a lentigo and melanocytic nevus, it has the slight potential to develop into melanoma.
  • [MeSH-major] Nevus, Pigmented. Skin Neoplasms


22. Bragg JW, Swindle L, Halpern AC, Marghoob AA: Agminated acquired melanocytic nevi of the common and dysplastic type. J Am Acad Dermatol; 2005 Jan;52(1):67-73
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  • [Title] Agminated acquired melanocytic nevi of the common and dysplastic type.
  • We previously reported a single case of agminated acquired melanocytic nevi, consisting of a localized clustering of banal and atypical moles.
  • We examined the lesions clinically, with a dermoscope, with a Wood's light, and in 3 cases with UV photography so as to exclude nevus spilus from the differential diagnosis.
  • The presence of an underlying dysplastic nevus syndrome phenotype in 4 of the 5 cases raises the possibility that agminated nevi arise as a consequence of postzygotic loss of heterozygosity and, thus, may represent a type 2 segmental manifestation of the atypical mole syndrome phenotype.
  • [MeSH-major] Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • (PMID = 15627083.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Garrido-Ríos AA, Carrera C, Puig S, Aguilera P, Salerni G, Malvehy J: Homogeneous blue pattern in an acral congenital melanocytic nevus. Dermatology; 2008;217(4):315-7
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  • [Title] Homogeneous blue pattern in an acral congenital melanocytic nevus.
  • Dermoscopy in acquired acral melanocytic nevi has been widely studied.
  • This is in contrast with the little information about the dermoscopic characteristics in congenital acral melanocytic nevi.
  • We report a 46-year-old man who was referred due to a lesion on his right sole present since childhood corresponding to an acral congenital nevus.
  • The homogeneous blue pattern has previously been associated with blue nevus and skin metastasis of melanoma.
  • [MeSH-major] Foot. Nevus, Pigmented / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Dermoscopy. Diagnosis, Differential. Humans. Male. Melanocytes / pathology. Middle Aged. Nevus, Blue / pathology

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  • [Copyright] 2008 S. Karger AG, Basel.
  • (PMID = 18714159.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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24. Zalaudek I, Grinschgl S, Argenziano G, Marghoob AA, Blum A, Richtig E, Wolf IH, Fink-Puches R, Kerl H, Soyer HP, Hofmann-Wellenhof R: Age-related prevalence of dermoscopy patterns in acquired melanocytic naevi. Br J Dermatol; 2006 Feb;154(2):299-304
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Age-related prevalence of dermoscopy patterns in acquired melanocytic naevi.
  • BACKGROUND: Based on the dermoscopic classification of acquired melanocytic naevi, six different dermoscopic types can be distinguished by morphology (globular, globular-reticular, globular-homogeneous, reticular, reticular-homogeneous, homogeneous) and by pigment distribution (uniform, central hyperpigmentation, central hypopigmentation, peripheral hyperpigmentation, peripheral hypopigmentation, multifocal hyper/hypopigmentation).
  • OBJECTIVES: To evaluate whether the age of the patient influences the predominant naevus pattern observed in individuals with multiple acquired melanocytic naevi.
  • Individuals with at least 10 melanocytic naevi were selected consecutively until a total of 10 individuals in each of five age groups was obtained.
  • Digitized images of acquired melanocytic naevi, defined as benign melanocytic proliferations having a diameter of at least 5 mm with a macular component and which were not apparent within the first year of life, were evaluated by dermoscopic criteria.
  • Uniform pigmentation was most common in melanocytic naevi in the youngest age group, while central hyperpigmentation was predominantly seen in the group of individuals aged 16-30 years.
  • CONCLUSIONS: The predominance of dermoscopic types of melanocytic naevi varies according to the individual's age.
  • Awareness of the age-related dermoscopic predominance of melanocytic naevi might allow more accurate recognition of dermoscopic patterns of melanocytic skin lesions that are unusual with respect to the individual's age.
  • Furthermore, the observations made in this study raise interesting questions regarding naevus evolution.
  • [MeSH-major] Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • (PMID = 16433800.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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25. Takata M, Saida T: Genetic alterations in melanocytic tumors. J Dermatol Sci; 2006 Jul;43(1):1-10
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  • [Title] Genetic alterations in melanocytic tumors.
  • In the last decade, significant progress has been made in our understanding of the genetic alterations in melanocytic tumors.
  • The most exciting finding is the discovery of oncogenic BRAF mutations in both malignant melanoma and melanocytic nevi.
  • This finding indicates that activation of the mitogen-activated protein kinase pathway may be a critical initiating step of melanocytic neoplasia, and that the fundamental difference between melanoma and nevi may lie in the inhibitory machinery for this oncogenic signaling.
  • Different patterns of genetic alterations have also been identified among different kinds of melanocytic nevi.
  • While acquired nevi and small congenital nevi show a high frequency of BRAF mutations regardless of their anatomic localization, the mutations were rare in medium-sized congenital nevi and giant congenital nevi.
  • The clear differences in genetic aberration patterns have significant clinical implications in the diagnosis and treatment of melanocytic tumors.
  • [MeSH-major] Melanoma / genetics. Nevus, Pigmented / genetics. Skin Neoplasms / genetics

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  • (PMID = 16750612.001).
  • [ISSN] 0923-1811
  • [Journal-full-title] Journal of dermatological science
  • [ISO-abbreviation] J. Dermatol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / MITF protein, human; 0 / Microphthalmia-Associated Transcription Factor; 0 / Tumor Suppressor Protein p14ARF; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / HRAS protein, human; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras)
  • [Number-of-references] 69
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26. Ozdemir F, Karaarslan IK, Akalin T: Variations in the dermoscopic features of acquired acral melanocytic nevi. Arch Dermatol; 2007 Nov;143(11):1378-84
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  • [Title] Variations in the dermoscopic features of acquired acral melanocytic nevi.
  • OBJECTIVE: To investigate the dermoscopic features of acquired acral melanocytic nevi (AAMN) in a white population in Turkey.
  • [MeSH-major] Dermoscopy. Extremities. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis

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  • [CommentIn] Arch Dermatol. 2007 Nov;143(11):1423-6 [18025367.001]
  • (PMID = 18025361.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. de Maleissye MF, Beauchet A, Aegerter P, Saiag P, Mahé E: Parents' attitudes related to melanocytic nevus count in children. Eur J Cancer Prev; 2010 Nov;19(6):472-7
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  • [Title] Parents' attitudes related to melanocytic nevus count in children.
  • Sun exposure, fair phototype, and a high common melanocytic nevus (MN) count have been identified as the most important risk factors for melanoma.
  • MN are mainly acquired during childhood, and their relationship to sun exposure, sunburn, and light skin complexion is well documented.
  • [MeSH-major] Attitude to Health. Melanoma / prevention & control. Nevus, Pigmented / prevention & control. Skin Neoplasms / prevention & control

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  • (PMID = 20736840.001).
  • [ISSN] 1473-5709
  • [Journal-full-title] European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
  • [ISO-abbreviation] Eur. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Sunscreening Agents
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28. Ferrara G, Brasiello M, Annese P, Francione S, Giorgio CM, Moscarella E, Zalaudek I, Argenziano G: Desmoplastic nevus: clinicopathologic keynotes. Am J Dermatopathol; 2009 Oct;31(7):718-22
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  • [Title] Desmoplastic nevus: clinicopathologic keynotes.
  • We describe 3 cases of desmoplastic nevus with special emphasis on some repetitive dermoscopic and histopathologic features, which-if confirmed on larger series-could allow to identify desmoplastic nevus as a specific clinicopathologic entity within the spectrum of acquired melanocytic nevi.
  • [MeSH-major] Nevus / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Dermoscopy. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / pathology. Humans. Immunohistochemistry. Melanoma / pathology. Middle Aged. Nevus, Epithelioid and Spindle Cell / pathology

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  • (PMID = 19684509.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Moreno-Ramirez D, Ferrandiz L, Rios-Martin JJ, Camacho FM: Dysplastic pointillist nevus. Arch Dermatol; 2005 Jun;141(6):763-4
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  • [Title] Dysplastic pointillist nevus.
  • BACKGROUND: Three cases of pointillist nevus, which is a distinctive clinical type of benign melanocytic nevus with variegated pigment, have been described in the literature to date.
  • OBSERVATIONS: A 24-year-old man presented with an acquired melanocytic lesion composed of multiple tiny pigmented dots.
  • Dermoscopy revealed multiple brown globules on a reddish skin-colored background, and histologic examination demonstrated architectural disorder with cytologic atypia.
  • Conclusion To the best of our knowledge, we report a case of dysplastic pointillist nevus.
  • [MeSH-major] Dysplastic Nevus Syndrome / pathology. Dysplastic Nevus Syndrome / physiopathology

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  • (PMID = 15967924.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Ferrandiz L, Moreno-Ramirez D, Camacho FM: Shave excision of common acquired melanocytic nevi: cosmetic outcome, recurrences, and complications. Dermatol Surg; 2005 Sep;31(9 Pt 1):1112-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Shave excision of common acquired melanocytic nevi: cosmetic outcome, recurrences, and complications.
  • BACKGROUND: Surgical treatment of benign melanocytic lesions demands the application of simple and effective surgical techniques with the possibility of performing a histopathologic examination with an acceptable cosmetic outcome.
  • MATERIAL AND METHODS: Shave excision of common acquired melanocytic nevi was performed.
  • RESULTS: Over a 12-week period, 204 common acquired melanocytic nevi were shaved.
  • DISCUSSION: An acceptable cosmetic result, along with a low rate of recurrence, should be the aim of the surgical treatment of benign melanocytic lesions.
  • [MeSH-major] Nevus, Pigmented / surgery. Postoperative Complications. Skin Neoplasms / surgery

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  • (PMID = 16164859.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Baba M, Bal N: Efficacy and safety of the short-pulse erbium:YAG laser in the treatment of acquired melanocytic nevi. Dermatol Surg; 2006 Feb;32(2):256-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Efficacy and safety of the short-pulse erbium:YAG laser in the treatment of acquired melanocytic nevi.
  • BACKGROUND: Various laser systems have been used in the treatment of acquired melanocytic nevi.
  • To date, no study has evaluated the efficacy and safety of an erbium:yttrium-aluminum-garnet (YAG) laser, with its small penetration depth and fewer adverse effects, in the treatment of acquired melanocytic nevi.
  • OBJECTIVE: To investigate the efficacy and safety of the short-pulse erbium:YAG laser in the treatment of acquired melanocytic nevi.
  • Each specimen was histopathologically and immunohistochemically examined for the presence of nevus cells.
  • CONCLUSIONS: Short-pulse erbium:YAG laser treatment is an effective and safe method for removing acquired melanocytic nevi.
  • [MeSH-major] Laser Therapy / methods. Nevus, Pigmented / surgery. Skin Neoplasms / surgery

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  • (PMID = 16442047.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. Yu X, Nagai H, Nishigori C, Horikawa T: Acquired unilateral melanocytic nevi in otherwise normal skin. Dermatology; 2008;217(1):63-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acquired unilateral melanocytic nevi in otherwise normal skin.
  • We describe a case with numerous melanocytic nevi in otherwise normal skin.
  • Skin biopsy from a pigmented lesion shows a pathological change in compound-type melanocytic nevus without any atypical changes.
  • Speckled lentiginous nevus is known to have multiple melanocytic lesions on the underlying brown macule from birth.
  • Partial unilateral lentiginosis is characterized by unilateral lentigines with histopathological changes in lentigo but not melanocytic proliferation in the dermis.
  • Agminated melanocytic nevi tend to be clustered together in a circumscribed area, whereas in the present case melanocytic nevi were segmentally arranged but not agminated.
  • We consider that this is an unusual type of mosaicism of melanocytic disorders.
  • [MeSH-major] Nevus, Pigmented / pathology. Skin / pathology. Skin Neoplasms / pathology

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • [CommentIn] Dermatology. 2009;218(4):387-8 [18974631.001]
  • (PMID = 18401177.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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33. Zarineh A, Kozovska ME, Brown WG, Elder DE, Rabkin MS: Smooth muscle hamartoma associated with a congenital pattern melanocytic nevus, a case report and review of the literature. J Cutan Pathol; 2008 Oct;35 Suppl 1:83-6
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  • [Title] Smooth muscle hamartoma associated with a congenital pattern melanocytic nevus, a case report and review of the literature.
  • Smooth muscle hamartoma (SMH) is a rare benign congenital or acquired lesion sometimes associated with Becker's nevus (Becker's melanosis).
  • We report an unusual lesion with combined features of SMH and melanocytic nevus.
  • Lesional melanocytes acquired a spindled morphology in the deeper dermis.
  • The melanocytic component strongly expressed melanoma antigen recognized by T-cells-1 (MART-1) and HMB-45.
  • Unlike a recently reported case of SMH combined with a melanocytic nevus and basal cell carcinoma, the current lesion did not occur in association with a Becker's nevus.
  • [MeSH-major] Hamartoma / complications. Hamartoma / pathology. Muscle, Smooth / pathology. Nevus, Pigmented / complications. Nevus, Pigmented / congenital

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  • [Copyright] Copyright Blackwell Munksgaard 2008.
  • (PMID = 18544054.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, Neoplasm; 0 / Calmodulin-Binding Proteins; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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34. Tokuda Y, Saida T, Murata H, Murase S, Oohara K: Histogenesis of congenital and acquired melanocytic nevi based on histological study of lesion size and thickness. J Dermatol; 2010 Dec;37(12):1011-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histogenesis of congenital and acquired melanocytic nevi based on histological study of lesion size and thickness.
  • The histogenesis of melanocytic nevi is poorly understood.
  • It is important to determine the differences and similarities in histogenesis between congenital and acquired nevi.
  • To clarify the histogenic differences between acquired melanocytic nevi (AMN) and congenital melanocytic nevi (CMN), diameter and depth of nevus cells (tumor thickness) were examined in histological specimens from 80 cases of CMN and 71 cases of AMN, and these nevi were classified according to Mark's pathological CMN criteria.
  • In all cases, giant CMN nevus cells were found in the lower marginal portion of excised specimens.
  • (ii) proliferation of nevus cells after arrival at the epidermis, and nevus cell distribution affected by adnexa and dermal differentiation; and (iii) arising after completion of skin development before birth.
  • [MeSH-major] Melanocytes / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • [Copyright] © 2010 Japanese Dermatological Association.
  • (PMID = 21083702.001).
  • [ISSN] 1346-8138
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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35. Perra MT, Colombari R, Maxia C, Zucca I, Piras F, Corbu A, Bravo S, Scarpa A, Sirigu P: Finding of conjunctival melanocytic pigmented lesions within pterygium. Histopathology; 2006 Mar;48(4):387-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Finding of conjunctival melanocytic pigmented lesions within pterygium.
  • Melanocytic pigmented lesions commonly occur in the conjunctiva, although they have not been previously reported in pterygium, a common lesion which originates from conjunctiva.
  • Our aim was to evaluate the possibility of an association between pterygium and conjunctival melanocytic pigmented lesions.
  • Histological sections were evaluated for the presence of melanocytic pigmented lesions.
  • Nine cases of conjunctival melanocytic, pigmented lesions within pterygium were found and were classified according to the histopathological criteria previously published for pigmented lesions of the conjunctiva, as naevi and primary acquired melanosis (PAM) with varying degrees of atypia.
  • Five of the nine cases showed primary acquired melanosis without atypia, while two cases had atypia; one case showed features of compound naevus and one lesion was designated as subepithelial naevus.
  • CONCLUSIONS: Our findings suggest that conjunctival melanocytic, pigmented lesions occasionally occur in pterygium.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Melanosis / pathology. Nevus, Pigmented / pathology. Pterygium / pathology

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  • (PMID = 16487360.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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36. Stefanaki C, Stefanaki K, Antoniou C, Argyrakos T, Stratigos A, Patereli A, Katsambas A: G1 cell cycle regulators in congenital melanocytic nevi. Comparison with acquired nevi and melanomas. J Cutan Pathol; 2008 Sep;35(9):799-808
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] G1 cell cycle regulators in congenital melanocytic nevi. Comparison with acquired nevi and melanomas.
  • METHODS: In order to elucidate the behavior of congenital nevocytes and to define any possible similarities or differences with common nevi and melanomas, we investigated the expression of Ki-67, Rb, p16, cyclin D1, p53 and p21/Waf-1 in 41 congenital nevi, 16 melanomas and 20 acquired common nevi by immunohistochemistry.
  • CONCLUSION: Our data regarding the immunohistochemical expression of Rb, p16, p53, cyclin D1 and Ki-67 in congenital nevi indicate that either the alteration of their expression is not an initiating event in melanoma formation or, alternatively, congenital melanocytic nevi may not be the first step in malignant transformation.
  • [MeSH-major] Cell Cycle Proteins / metabolism. G1 Phase / physiology. Melanoma / metabolism. Nevus, Pigmented / metabolism. Skin Neoplasms / metabolism


37. Goldenberg-Cohen N, Cohen Y, Rosenbaum E, Herscovici Z, Chowers I, Weinberger D, Pe'er J, Sidransky D: T1799A BRAF mutations in conjunctival melanocytic lesions. Invest Ophthalmol Vis Sci; 2005 Sep;46(9):3027-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] T1799A BRAF mutations in conjunctival melanocytic lesions.
  • PURPOSE: To gain a better understanding of the molecular events leading to the development of conjunctival melanocytic lesions and conjunctival melanoma, this study was conducted to investigate the presence of T1799A BRAF oncogenic mutation in these lesions.
  • METHODS: Forty-eight surgically excised conjunctival melanocytic lesions from 48 patients were examined for the presence of the BRAF T1799A mutation.
  • Fifteen lesions were conjunctival primary acquired melanosis (PAM; 11 without atypia and 4 with atypia) and five were conjunctival melanomas.
  • [MeSH-major] Conjunctival Neoplasms / genetics. Melanoma / genetics. Melanosis / genetics. Mutation. Nevus, Pigmented / genetics. Proto-Oncogene Proteins B-raf / genetics

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  • (PMID = 16123397.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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38. Navarini AA, Kolm I, Calvo X, Kamarashev J, Kerl K, Conrad C, French LE, Braun RP: Trauma as triggering factor for development of melanocytic nevi. Dermatology; 2010;220(4):291-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Trauma as triggering factor for development of melanocytic nevi.
  • The mechanisms for the development of acquired melanocytic nevi remain mostly unclear.
  • Here we report a case of eruptive nevi that developed after localized superficial trauma, and review the currently known cellular and triggering factors for acquired melanocytic nevi.
  • Damaged keratinocytes and inflammatory cells can release growth factors inducing nevus cell proliferation, and immunosuppression could end cellular surveillance keeping preexisting nevus cell nests in check.
  • [MeSH-major] Nevus, Pigmented / etiology. Skin / injuries. Skin Neoplasms / etiology

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  • [Copyright] Copyright (c) 2010 S. Karger AG, Basel.
  • (PMID = 20424415.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 51
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39. Batistatou A, Zioga A, Panelos J, Massi D, Agnantis NJ, Charalabopoulos K: A new concept of melanocytic neoplasia pathogenesis based on the phenotype of common acquired nevi. Med Hypotheses; 2007;69(6):1334-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A new concept of melanocytic neoplasia pathogenesis based on the phenotype of common acquired nevi.
  • Common melanocytic nevi are ubiquitous lesions which in some cases constitute a risk factor for the development of melanoma.
  • To date, despite long term research there are no known molecular hallmarks for nevus development.
  • We have observed that common acquired nevi excised from the same individual share remarkable similarity in their microscopic appearance and in the immunohistochemical expression of E-cadherin.
  • Based on these observations, we hypothesize that all melanocytes are genetically similar in the same individual and changes predisposing to neoplasia are a global melanocytic event characteristic for each person and propose a microgenomics/proteomics approach to test this hypothesis.
  • [MeSH-major] Melanocytes / metabolism. Melanoma / etiology. Neoplasms / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / etiology
  • [MeSH-minor] Adolescent. Adult. Cadherins / biosynthesis. Dysplastic Nevus Syndrome / pathology. Female. Humans. Immunohistochemistry / methods. Male. Middle Aged. Precancerous Conditions / pathology. Risk Factors

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  • (PMID = 17459602.001).
  • [ISSN] 0306-9877
  • [Journal-full-title] Medical hypotheses
  • [ISO-abbreviation] Med. Hypotheses
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Cadherins
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40. Valiukeviciene S, Miseviciene I, Gollnick H: The prevalence of common acquired melanocytic nevi and the relationship with skin type characteristics and sun exposure among children in Lithuania. Arch Dermatol; 2005 May;141(5):579-86
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The prevalence of common acquired melanocytic nevi and the relationship with skin type characteristics and sun exposure among children in Lithuania.
  • OBJECTIVE: To evaluate the prevalence of common acquired melanocytic nevi and its relationship with pigmentary characteristics and severe sunburns in children.
  • MAIN OUTCOME MEASURES: Atypical melanocytic nevi were defined according to the clinical criteria of the ABCDE rule.
  • RESULTS: The median number of all common acquired melanocytic nevi was 12 in boys and 11 in girls; the median number of melanocytic nevi 2 mm or larger in boys and girls was 4.
  • After adjustment for age and sex, it was found that children who had severe sunburns in summer and skin type I had a higher density of all melanocytic nevi and melanocytic nevi 2 mm or larger.
  • The prevalence of atypical melanocytic nevi was 7% in all children and was age dependent (age 4-5 years, 1%; 9-10 years, 4%; 14-15 years, 16%).
  • Three percent of children had congenital melanocytic nevi.
  • CONCLUSIONS: The total number of common acquired melanocytic nevi in children increased with age.
  • There was a positive association between severe sunburns, the tendency of the skin to burn, and the number of all melanocytic nevi and nevi 2 mm or larger.
  • [MeSH-major] Environmental Exposure. Nevus, Pigmented / epidemiology. Skin Neoplasms / epidemiology. Skin Pigmentation. Sunlight

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  • (PMID = 15897379.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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41. Valiukeviciene S, Gollnick H, Stang A: Body-site distribution of common acquired melanocytic nevi associated with severe sunburns among children in Lithuania. Int J Dermatol; 2007 Dec;46(12):1242-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Body-site distribution of common acquired melanocytic nevi associated with severe sunburns among children in Lithuania.
  • BACKGROUND: The aim of this cross-sectional study is to provide information on subsite-specific densities of melanocytic nevi by age, sex, and in relation to the history of severe sunburns.
  • Site-specific numbers and densities of melanocytic nevi of all sizes and nevi 2 mm or greater were studied.
  • We used log-linear and Poisson regression models to estimate the effects of age, sex, and severe sunburns on the nevus density.
  • Estimates of the relative nevus densities related to the history of severe sunburns tend to be small with the exception of the legs for nevi 2 mm or greater (relative nevus density = 2.09, 95% CI 1.49-2.93).
  • CONCLUSION: Nevus densities are highest on maximally or intermittently sun-exposed skin areas.
  • With the exception of the legs among women, the subsite-specific ranking of nevus densities among adolescents follows a similar ranking as the skin melanoma incidence in Lithuania.
  • [MeSH-major] Nevus, Pigmented / epidemiology. Skin Neoplasms / epidemiology

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  • (PMID = 18173516.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Seidenari S, Pellacani G, Martella A: Acquired melanocytic lesions and the decision to excise: role of color variegation and distribution as assessed by dermoscopy. Dermatol Surg; 2005 Feb;31(2):184-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acquired melanocytic lesions and the decision to excise: role of color variegation and distribution as assessed by dermoscopy.
  • OBJECTIVE: To assess color type and distribution in dermoscopic melanocytic lesion images and to analyze the influence of color parameters on the diagnostic process and the decision to excise.
  • CONCLUSION: In dermoscopic images, color parameters are essential elements for the diagnosis of atypical nevus, which can be differentiated from both a clearly benign lesion and a melanoma.
  • [MeSH-minor] Decision Support Techniques. Humans. Nevus, Pigmented / diagnosis. Nevus, Pigmented / pathology. Nevus, Pigmented / surgery. Predictive Value of Tests. ROC Curve. Retrospective Studies

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  • (PMID = 15762212.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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43. Altamura D, Zalaudek I, Sera F, Argenziano G, Fargnoli MC, Rossiello L, Peris K: Dermoscopic changes in acral melanocytic nevi during digital follow-up. Arch Dermatol; 2007 Nov;143(11):1372-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dermoscopic changes in acral melanocytic nevi during digital follow-up.
  • OBJECTIVE: To investigate changes in dermoscopic patterns of acquired acral melanocytic nevi (AAMN) over time.
  • [MeSH-major] Dermoscopy. Diagnosis, Computer-Assisted. Extremities. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis

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  • [CommentIn] Arch Dermatol. 2007 Nov;143(11):1423-6 [18025367.001]
  • (PMID = 18025360.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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44. La Placa M, Ambretti S, Bonvicini F, Venturoli S, Bianchi T, Varotti C, Zerbini M, Musiani M: Presence of high-risk mucosal human papillomavirus genotypes in primary melanoma and in acquired dysplastic melanocytic naevi. Br J Dermatol; 2005 May;152(5):909-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Presence of high-risk mucosal human papillomavirus genotypes in primary melanoma and in acquired dysplastic melanocytic naevi.
  • OBJECTIVES: To investigate the presence of HPV DNA and the prevalence of different high-risk mucosal HPV genotypes in primary melanoma (PM) and in acquired dysplastic melanocytic naevi (ADMN).
  • CONCLUSIONS: Using our PCR-ELISA methods, the detection of mucosal high-risk HPV genotypes in 24% of precursor lesions (ADMN) and in 27% of PMs adds to the body of evidence indicating a colocalization of mucosal HPV and tumoral melanocytic pathologies.
  • [MeSH-major] Melanoma / virology. Nevus, Pigmented / virology. Papillomaviridae / isolation & purification. Precancerous Conditions / virology. Skin Neoplasms / virology

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  • [CommentIn] Br J Dermatol. 2006 Mar;154(3):572; author reply 573 [16445807.001]
  • (PMID = 15888145.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Viral
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45. Gallardo F, Toll A, Malvehy J, Mascaró-Galy JM, Lloreta J, Barranco C, Pujol RM: Large atypical melanocytic nevi in recessive dystrophic epidermolysis bullosa: clinicopathological, ultrastructural, and dermoscopic study. Pediatr Dermatol; 2005 Jul-Aug;22(4):338-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Large atypical melanocytic nevi in recessive dystrophic epidermolysis bullosa: clinicopathological, ultrastructural, and dermoscopic study.
  • A 3-year-old boy with recessive dystrophic epidermolysis bullosa developed a rapidly growing, large, acquired irregular melanocytic nevus on the lower aspect of the back.
  • The lesion was clinically atypical and fulfilled the criteria for a malignant melanocytic proliferation.
  • Histopathologic examination disclosed a compound melanocytic nevus without melanocytic atypia.
  • Ultrastructural examination showed melanocytic cells located both at the roof and the floor of the blister.
  • Acquired melanocytic nevi showing atypical clinical features have been reported to occur in areas of blistering in patients with epidermolysis bullosa.
  • Histopathologic examination can show features of compound/junctional nevus as well as persistent/recurrent nevus.
  • The concept of "epidermolysis bullosa nevus" has been proposed to define these peculiar lesions.
  • [MeSH-major] Epidermolysis Bullosa Dystrophica / complications. Nevus, Pigmented / complications. Skin Neoplasms / complications


46. Chiu HH, Chen GS, Wu CS, Ke CL, Cheng ST: Phakomatosis cesioflammea with late-onset glaucoma and acquired nevus spilus-like lesion - 15 years of follow-up. Int J Dermatol; 2009 Apr;48(4):416-8
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  • [Title] Phakomatosis cesioflammea with late-onset glaucoma and acquired nevus spilus-like lesion - 15 years of follow-up.
  • Phakomatosis pigmentovascularis is a very rare disease characterized by coexistence of a capillary malformation with various melanocytic lesions, including dermal melanocytosis (Mongolian spots), nevus spilus, and nevus of Ota.
  • We present a 15-year-old Taiwanese male with phakomatosis cesioflammea who developed, during adolescence, a nevus spilus-like lesion and late-onset open angle glaucoma, suggesting that long-term ophthalmic follow-up is necessary in this type of patient.
  • [MeSH-major] Glaucoma, Open-Angle / complications. Neurocutaneous Syndromes / complications. Nevus, Pigmented / complications. Port-Wine Stain / complications. Skin Neoplasms / complications

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  • (PMID = 19335431.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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47. Sowa J, Kobayashi H, Ishii M, Kimura T: Histopathologic findings in Unna's nevus suggest it is a tardive congenital nevus. Am J Dermatopathol; 2008 Dec;30(6):561-6
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  • [Title] Histopathologic findings in Unna's nevus suggest it is a tardive congenital nevus.
  • Bernard Ackerman's clinical histopathologic classification of nevi, the essential histopathologic finding of an Unna's nevus is localization of melanocytic nevus cells to a markedly thickened papillary dermis of an exophytic lesion.
  • We examined that melanocytic nevus cells were not just localized to the exophytic portion but were also commonly distributed below it (81 lesions, 86.2%).
  • Melanocytic nevus cells were found in a periadnexal distribution in most of the lesions in which they extended below the exophytic part and were most frequently noted around hair follicles (60 lesions, 63.8%), then around eccrine ducts (43 lesions, 45.7%), and least frequently around sebaceous glands or ducts (36 lesions, 38.3%).
  • Nests of melanocytic nevus cells were present in follicular epithelium in 7 lesions, sebaceous ducts in 1 lesion, and eccrine ducts in 1 lesion.
  • Moreover, type A nevus cells containing melanin granules were observed in 16 lesions (17.0%) when they were distributed around hair follicles, in 8 lesions (8.5%) when distributed around sebaceous glands or ducts, and in 1 lesion (1.1%) when distributed around eccrine ducts.
  • Although Unna's nevus is clinically an acquired nevus, it has many histopathologic characteristics of a congenital melanocytic nevus and is therefore likely a tardive congenital lesion.
  • [MeSH-major] Nevus, Pigmented / congenital. Nevus, Pigmented / pathology. Skin Neoplasms / congenital. Skin Neoplasms / pathology

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  • (PMID = 19033929.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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48. Rados J, Pastar Z, Lipozencić J, Ilić I, Stulhofer Buzina D: Halo phenomenon with regression of acquired melanocytic nevi: a case report. Acta Dermatovenerol Croat; 2009;17(2):139-43
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  • [Title] Halo phenomenon with regression of acquired melanocytic nevi: a case report.
  • Dermatologists should be familiar with the possible changes in benign melanocytic nevi, halo reactions and possible complete regression of melanocytic nevi.
  • [MeSH-major] Nevus, Halo / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • (PMID = 19595273.001).
  • [ISSN] 1330-027X
  • [Journal-full-title] Acta dermatovenerologica Croatica : ADC
  • [ISO-abbreviation] Acta Dermatovenerol Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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49. Cho SB, Park SJ, Kim MJ, Bu TS: Treatment of acquired bilateral nevus of Ota-like macules (Hori's nevus) using 1064-nm Q-switched Nd:YAG laser with low fluence. Int J Dermatol; 2009 Dec;48(12):1308-12
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  • [Title] Treatment of acquired bilateral nevus of Ota-like macules (Hori's nevus) using 1064-nm Q-switched Nd:YAG laser with low fluence.
  • BACKGROUND: Acquired bilateral nevus of Ota-like macules (ABNOM), or Hori's nevus, is a common dermal melanocytic hyperpigmentation in Asians.
  • [MeSH-major] Lasers, Solid-State / therapeutic use. Nevus of Ota / surgery. Skin Neoplasms / surgery

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  • (PMID = 20415671.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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50. Hamm H: [Congenital melanocytic nevi--a multifaceted problem]. MMW Fortschr Med; 2007 Feb 8;149(6):33-5
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  • [Title] [Congenital melanocytic nevi--a multifaceted problem].
  • Congenital melanocytic nevi are specific pigmented lesions that differ from acquired melanocytic nevi in terms of the age at which they develop and, usually, also in their clinical and histological features.
  • Their potential for malignant transformation and their association with leptomeningeal seeding of nevomelanocytic cells have long been known, at least in the case of large melanocytic nevi.
  • [MeSH-major] Melanoma / congenital. Nevus, Pigmented / congenital. Skin Neoplasms / congenital

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  • (PMID = 17619400.001).
  • [ISSN] 1438-3276
  • [Journal-full-title] MMW Fortschritte der Medizin
  • [ISO-abbreviation] MMW Fortschr Med
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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51. Demirkan NC, Kesen Z, Akdag B, Larue L, Delmas V: The effect of the sun on expression of beta-catenin, p16 and cyclin d1 proteins in melanocytic lesions. Clin Exp Dermatol; 2007 Nov;32(6):733-9
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  • [Title] The effect of the sun on expression of beta-catenin, p16 and cyclin d1 proteins in melanocytic lesions.
  • AIM: To determine the role of these cell cycle-related proteins and high-risk sun exposure in the biological behaviour of melanocytic lesions.
  • METHODS: We used immunohistochemistry to examine 28 melanocytic naevi (MN; 9 congenital and 19 acquired types) and 24 primary cutaneous malignant melanomas (CMM; 19 nodular melanomas, 3 lentigo maligna melanomas, 1 acral lentiginous melanoma and 1 superficial spreading melanoma) for the presence of p16, cyclin D1 and beta-catenin.
  • The melanocytic lesions were classified into two groups to examine the effects of UVR on these three proteins: high risk of sun exposure (chronically sun damaged; CSD), or low risk of sun exposure (nonchronically sun damaged; non-CSD).
  • Overproduction of beta-catenin was not common in CSD melanocytic lesions, but was more frequent in non-CSD melanocytic lesions (P = 0.027).
  • CONCLUSION: An immunohistochemical panel including melanocytic markers enriched by p16 and cyclin D1 could be used to differentiate some borderline melanocytic lesions.
  • In addition, the Wnt/beta-catenin pathway was more frequently activated in non-CSD than in CSD melanocytic lesions.
  • [MeSH-major] Cell Cycle Proteins / biosynthesis. Melanoma / metabolism. Neoplasm Proteins / biosynthesis. Nevus, Pigmented / metabolism. Skin Neoplasms / metabolism. Sunlight

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  • (PMID = 17868395.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Neoplasm Proteins; 0 / beta Catenin; 136601-57-5 / Cyclin D1
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52. Manganoni AM, Tucci G, Venturini M, Farisoglio C, Calzavara-Pinton PG: Repeated equally effective suberythemogenic exposures to ultraviolet (UV)A1 or narrowband UVB induce similar changes of the dermoscopic pattern of acquired melanocytic nevi that can be prevented by high-protection UVA-UVB sunscreens. J Am Acad Dermatol; 2008 May;58(5):763-8
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  • [Title] Repeated equally effective suberythemogenic exposures to ultraviolet (UV)A1 or narrowband UVB induce similar changes of the dermoscopic pattern of acquired melanocytic nevi that can be prevented by high-protection UVA-UVB sunscreens.
  • BACKGROUND: Sunlight modifies the size and the dermoscopic pattern of acquired melanocytic nevi (AMN).
  • [MeSH-major] Nevus, Pigmented / pathology. Nevus, Pigmented / prevention & control. Skin Neoplasms / pathology. Skin Neoplasms / prevention & control. Sunscreening Agents / therapeutic use. Ultraviolet Rays / adverse effects


53. Gefeller O, Tarantino J, Lederer P, Uter W, Pfahlberg AB: The relation between patterns of vacation sun exposure and the development of acquired melanocytic nevi in German children 6-7 years of age. Am J Epidemiol; 2007 May 15;165(10):1162-9
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  • [Title] The relation between patterns of vacation sun exposure and the development of acquired melanocytic nevi in German children 6-7 years of age.
  • Sun exposure is the main environmental risk factor for the development of melanocytic nevi.
  • Although the general association is not disputed, the interplay between intense intermittent and the cumulative amount of sun exposure in defining the promoting effect on melanocytic nevus development is an area of debate.
  • Trained staff members ascertained total body counts of melanocytic nevi in a cross-sectional study of 2,189 children 6-7 years of age who were recruited in two German centers in 2002.
  • The distribution of melanocytic nevi was skewed markedly to the right; therefore, a negative binomial regression model provided the appropriate framework for a multivariable analysis.
  • A steep gradient with respect to the (adjusted) number of melanocytic nevi was apparent only for the frequency of vacation episodes associated with sun exposure in areas with an intense ultraviolet radiation.
  • This observation supports the hypothesis that intermittent exposure to high doses of ultraviolet radiation plays an especially important role in nevus development.
  • [MeSH-major] Nevus, Pigmented / etiology. Skin Neoplasms / etiology. Sunlight / adverse effects

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  • (PMID = 17337756.001).
  • [ISSN] 0002-9262
  • [Journal-full-title] American journal of epidemiology
  • [ISO-abbreviation] Am. J. Epidemiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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54. Dratviman-Storobinsky O, Cohen Y, Frenkel S, Pe'er J, Goldenberg-Cohen N: Lack of oncogenic GNAQ mutations in melanocytic lesions of the conjunctiva as compared to uveal melanoma. Invest Ophthalmol Vis Sci; 2010 Dec;51(12):6180-2
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  • [Title] Lack of oncogenic GNAQ mutations in melanocytic lesions of the conjunctiva as compared to uveal melanoma.
  • The purpose of this study was to search for GNAQ209 mutations in conjunctival melanocytic lesions.
  • METHODS: Forty archival samples of conjunctival melanocytic lesions (conjunctival nevi, primary acquired melanosis, and conjunctival melanoma), 27 samples of uveal melanoma, and 11 samples of uveal melanoma metastases to the liver (3 of which matched primary uveal melanoma samples)-a total of 78 samples from 75 patients- were examined for the presence of GNAQ209 mutations by using chip-based, matrix-assisted laser-desorption time-of-flight (MALDI-TOF) mass spectrometry.
  • It was not detected in any of the other melanocytic lesions.
  • The lack of GNAQ mutations in conjunctival melanocytic lesions suggests the involvement of a different tumorigenic pathway from that of uveal melanoma.
  • [MeSH-major] Conjunctival Neoplasms / genetics. GTP-Binding Protein alpha Subunits / genetics. Melanoma / genetics. Melanosis / genetics. Mutation. Nevus, Pigmented / genetics. Uveal Neoplasms / genetics

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  • (PMID = 20631239.001).
  • [ISSN] 1552-5783
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers; 0 / DNA, Neoplasm; 0 / GNAQ protein, human; 0 / GTP-Binding Protein alpha Subunits; 0 / Oncogene Proteins
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55. Harrison SL, MacLennan R, Buettner PG: Sun exposure and the incidence of melanocytic nevi in young Australian children. Cancer Epidemiol Biomarkers Prev; 2008 Sep;17(9):2318-24
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  • [Title] Sun exposure and the incidence of melanocytic nevi in young Australian children.
  • The number of melanocytic nevi (MN) is an important risk factor for cutaneous melanoma.
  • The present study further investigated the relationship between sun exposure, the incidence of MN, and the prevalence of large acquired MN (>or=5 mm).
  • Almost all (97.7%) children had acquired new MN (median, 12), with a median incidence rate of 11.0 per year (interquartile range, 7.0-16.5).
  • Lifetime number of sunburns (P < 0.001) and the severity of sunburns experienced during follow-up (P < 0.001) were significantly related to the presence of large acquired MN at follow-up.
  • [MeSH-major] Nevus, Pigmented / etiology. Skin Neoplasms / etiology. Sunburn / complications. Sunlight / adverse effects

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  • (PMID = 18768500.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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56. Meguerditchian AN, Cheney RT, Kane JM 3rd: Nevus spilus with synchronous melanomas: case report and literature review. J Cutan Med Surg; 2009 Mar-Apr;13(2):96-101
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  • [Title] Nevus spilus with synchronous melanomas: case report and literature review.
  • BACKGROUND: Nevus spilus is a rare, acquired, and often large cutaneous lesion consisting of a light brown background macule containing varying numbers of small darker macular or papular areas.
  • OBJECTIVE: Nevus spilus may contain dysplastic melanocytic elements, and there are also reports of melanoma arising from nevus spilus.
  • CONCLUSION: We discuss a case of synchronous melanomas arising from a nevus spilus and potential management recommendations based on a review of the pertinent literature.
  • [MeSH-major] Melanoma / pathology. Neoplasms, Multiple Primary / pathology. Nevus / pathology. Skin Neoplasms / pathology

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  • (PMID = 19298778.001).
  • [ISSN] 1203-4754
  • [Journal-full-title] Journal of cutaneous medicine and surgery
  • [ISO-abbreviation] J Cutan Med Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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57. Wu J, Rosenbaum E, Begum S, Westra WH: Distribution of BRAF T1799A(V600E) mutations across various types of benign nevi: implications for melanocytic tumorigenesis. Am J Dermatopathol; 2007 Dec;29(6):534-7
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  • [Title] Distribution of BRAF T1799A(V600E) mutations across various types of benign nevi: implications for melanocytic tumorigenesis.
  • A description of mutation distribution in nevi could provide insight into the significance of this event in melanocytic tumorigenesis.
  • The nevi were inclusive of congenital (n = 34) and acquired (n = 101) nevi, dysplastic (n = 11) and nondysplastic (n = 124) nevi, and anogenital (n = 24) and common cutaneous (n = 111) nevi.
  • For acquired nevi, there was no association between BRAF mutations and sun exposure as inferred from anatomic site.
  • There were no significant differences in the mutation rates between congenital and acquired nevi (76% versus 81%; P = 0.5).
  • [MeSH-major] Melanocytes / pathology. Mutation. Nevus / genetics. Proto-Oncogene Proteins B-raf / genetics. Skin Neoplasms / genetics

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  • (PMID = 18032947.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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58. Dessars B, De Raeve LE, Morandini R, Lefort A, El Housni H, Ghanem GE, Van den Eynde BJ, Ma W, Roseeuw D, Vassart G, Libert F, Heimann P: Genotypic and gene expression studies in congenital melanocytic nevi: insight into initial steps of melanotumorigenesis. J Invest Dermatol; 2009 Jan;129(1):139-47
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  • [Title] Genotypic and gene expression studies in congenital melanocytic nevi: insight into initial steps of melanotumorigenesis.
  • Large congenital melanocytic nevi (CMNs) are said to have a higher propensity to malignant transformation compared with acquired nevi.
  • [MeSH-major] Gene Expression Regulation, Neoplastic. Melanocytes / metabolism. Nevus, Pigmented / genetics. Nevus, Pigmented / metabolism


59. Tannous ZS, Mihm MC Jr, Sober AJ, Duncan LM: Congenital melanocytic nevi: clinical and histopathologic features, risk of melanoma, and clinical management. J Am Acad Dermatol; 2005 Feb;52(2):197-203
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  • [Title] Congenital melanocytic nevi: clinical and histopathologic features, risk of melanoma, and clinical management.
  • Congenital melanocytic nevi occur in approximately 1% of newborns and are usually classified according to their size.
  • Giant congenital melanocytic nevi are most simply defined as melanocytic nevi that are greater than 20 cm in largest dimension; whereas small congenital nevi are defined as melanocytic nevi less that 1.5 cm in largest dimension.
  • Congenital nevi can exhibit distinctive histologic features that can help in differentiating them from common acquired nevi.
  • Giant congenital melanocytic nevi are associated with an increased risk of the development of melanoma.
  • In large part due to inconsistency in the reported literature describing patients with congenital melanocytic nevi, the risk of melanoma in these patients remains unclear and consistent guidelines for clinical management do not exist.
  • [MeSH-major] Melanoma / epidemiology. Nevus, Pigmented / congenital. Skin Neoplasms / congenital


60. Rodvall Y, Wahlgren CF, Ullén H, Wiklund K: Common melanocytic nevi in 7-year-old schoolchildren residing at different latitudes in Sweden. Cancer Epidemiol Biomarkers Prev; 2007 Jan;16(1):122-7
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  • [Title] Common melanocytic nevi in 7-year-old schoolchildren residing at different latitudes in Sweden.
  • BACKGROUND: Current epidemiologic research shows consistently that increased number of acquired common melanocytic nevi (CMN) is an important risk factor for cutaneous malignant melanoma.
  • [MeSH-major] Melanoma / epidemiology. Nevus, Pigmented / epidemiology. Skin Neoplasms / epidemiology

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  • (PMID = 17220340.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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61. Thomas NE: BRAF somatic mutations in malignant melanoma and melanocytic naevi. Melanoma Res; 2006 Apr;16(2):97-103
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  • [Title] BRAF somatic mutations in malignant melanoma and melanocytic naevi.
  • BRAF somatic mutations are frequently found in primary and metastatic melanomas and melanocytic naevi.
  • The origin of these acquired mutations remains unknown, but melanomas have a different BRAF mutational spectrum from other tumours, possibly resulting from unique environmental exposures.

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  • (PMID = 16567964.001).
  • [ISSN] 0960-8931
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA102096-03; United States / NCI NIH HHS / CA / K07 CA102096-03; United States / NCI NIH HHS / CA / CA102096; United States / NCI NIH HHS / CA / CA112243-03; United States / NCI NIH HHS / CA / K07 CA102096; United States / NCI NIH HHS / CA / R01 CA112243-03; United States / NCI NIH HHS / CA / CA112243; United States / NCI NIH HHS / CA / R01 CA112243
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 2.7.11.1 / raf Kinases; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; EC 2.7.11.25 / MAP Kinase Kinase Kinases
  • [Number-of-references] 110
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62. Furusato E, Hidayat AA, Man YG, Auerbach A, Furusato B, Rushing EJ: WT1 and Bcl2 expression in melanocytic lesions of the conjunctiva: an immunohistochemical study of 123 cases. Arch Ophthalmol; 2009 Aug;127(8):964-9
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  • [Title] WT1 and Bcl2 expression in melanocytic lesions of the conjunctiva: an immunohistochemical study of 123 cases.
  • OBJECTIVE: Recent studies indicate that WT1 and Bcl2 protein are detected in melanocytic lesions of the skin.
  • We examined, for the first time, WT1 and Bcl2 expression in a variety of conjunctival melanocytic lesions to evaluate their diagnostic utility compared with other melanocytic markers.
  • METHODS: Protein expression and localization of WT1 and Bcl2 were studied by means of immunolabeling and semiquantification in 123 conjunctival melanocytic lesions (71 benign nevi, 21 atypical nevi, 11 primary acquired melanosis, and 20 malignant melanomas).
  • WT1 and HMB45 frequently showed diffuse and strong staining in atypical nevi, primary acquired melanosis with atypia, and malignant melanomas compared with benign lesions.
  • CONCLUSIONS: Bcl2 is a highly sensitive immunohistochemical marker for melanocytic tumors of the conjunctiva; HMB45 and WT1 staining distinguishes benign from malignant lesions.
  • CLINICAL RELEVANCE: Our results show that HMB45 and WT1 immunolabeling is helpful in the evaluation of conjunctival melanocytic lesions.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Conjunctival Neoplasms / metabolism. Melanoma / metabolism. Neoplasm Proteins / metabolism. Nevus, Pigmented / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism. WT1 Proteins / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antigens, Neoplasm / metabolism. Child. Child, Preschool. Conjunctival Diseases / metabolism. Dysplastic Nevus Syndrome / metabolism. Dysplastic Nevus Syndrome / pathology. Female. Humans. Immunoenzyme Techniques. MART-1 Antigen. Male. Melanoma-Specific Antigens. Melanosis / metabolism. Melanosis / pathology. Middle Aged. S100 Proteins / metabolism. Young Adult

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  • (PMID = 19667332.001).
  • [ISSN] 1538-3601
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / S100 Proteins; 0 / WT1 Proteins
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63. Lebe B, Pabuççuoğlu U, Ozer E: The significance of Ki-67 proliferative index and cyclin D1 expression of dysplastic nevi in the biologic spectrum of melanocytic lesions. Appl Immunohistochem Mol Morphol; 2007 Jun;15(2):160-4
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  • [Title] The significance of Ki-67 proliferative index and cyclin D1 expression of dysplastic nevi in the biologic spectrum of melanocytic lesions.
  • Familial acquired dysplastic nevi carry a risk for the development of melanoma.
  • The aim of this study is to investigate cyclin D1 expression and Ki67 proliferative index in a group of melanocytic lesions to address the biologic significance of sporadic dysplastic nevi in the progression of melanocytic lesions.
  • Formalin-fixed paraffin-embedded material from 21 common melanocytic nevi, 42 dysplastic nevi, and 17 primary cutaneous MMs were examined.
  • However, there was no significant difference between dysplastic nevi and common melanocytic nevi in terms of cyclin D1 expression.
  • Ki-67 index was significantly higher in dysplastic nevi compared with common melanocytic nevi and to melanoma compared with dysplastic nevi.
  • The present study indicates significant differences in cyclin D1 expressions and Ki-67 indices among melanocytic lesions.
  • We think that dysplastic nevi are biologically separate from common melanocytic nevi in terms of proliferative activity.

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  • (PMID = 17525627.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 136601-57-5 / Cyclin D1
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64. Venesio T, Chiorino G, Balsamo A, Zaccagna A, Petti C, Scatolini M, Pisacane A, Sarotto I, Picciotto F, Risio M: In melanocytic lesions the fraction of BRAF V600E alleles is associated with sun exposure but unrelated to ERK phosphorylation. Mod Pathol; 2008 Jun;21(6):716-26
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  • [Title] In melanocytic lesions the fraction of BRAF V600E alleles is associated with sun exposure but unrelated to ERK phosphorylation.
  • BRAF(V600E) mutation has been frequently reported in different types of melanocytic lesions, but its role in melanomagenesis is poorly understood, having been associated with either the proliferative-induced MAPK pathway activation or the acquisition of oncogene-driven senescence.
  • To elucidate the relationships among BRAF/NRAS alterations, MAPK pathway activation, and sun exposure, we examined 22 acquired nevi and 18 cutaneus melanomas from 38 patients.
  • BRAF(V600E) mutation was detected in 50% of the acquired nevi and in 70% of the cutaneus melanomas in the absence of NRAS alterations.
  • Our findings indicate that in melanocytic lesions, BRAF(V600E) mutation can affect a subset of the cells and is associated with the type and quantity of sun exposure.
  • This mutation is independent of the nevo-melanoma progression and unrelated to ERK phosphorylation, suggesting that alternative mechanisms to the MAPK activation are also involved in this type of transformation.
  • [MeSH-minor] Adult. Aged. Base Sequence. Female. Humans. Male. Microdissection. Middle Aged. Mitogen-Activated Protein Kinase 1 / metabolism. Mitogen-Activated Protein Kinase 3 / metabolism. Molecular Sequence Data. Mutation. Nevus, Pigmented / genetics. Nevus, Pigmented / metabolism. Phosphorylation

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  • (PMID = 18408659.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3
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65. Hofmann UB, Bröcker EB, Hamm H: Simultaneous onset of segmental vitiligo and a halo surrounding a congenital melanocytic naevus. Acta Derm Venereol; 2009;89(4):402-6
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  • [Title] Simultaneous onset of segmental vitiligo and a halo surrounding a congenital melanocytic naevus.
  • Unlike in common melanocytic naevi, an acquired leukoderma (halo) surrounding a congenital melanocytic naevus is a rare phenomenon.
  • A 6-year-old boy developed a depigmentation around a congenital melanocytic naevus on the right thigh.
  • The simultaneous occurrence of a halo phenomenon around a congenital melanocytic naevus and segmental vitiligo, as well as identical histological and immunohistological findings in both pigmented lesions, suggest shared immunological mechanisms.
  • [MeSH-major] Nevus, Pigmented / immunology. Skin Neoplasms / immunology. Skin Pigmentation / immunology. Vitiligo / immunology

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  • (PMID = 19688155.001).
  • [ISSN] 1651-2057
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Neoplasm Proteins
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66. Cash SH, Dever TT, Hyde P, Lee JB: Epidermolysis bullosa nevus: an exception to the clinical and dermoscopic criteria for melanoma. Arch Dermatol; 2007 Sep;143(9):1164-7
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  • [Title] Epidermolysis bullosa nevus: an exception to the clinical and dermoscopic criteria for melanoma.
  • BACKGROUND: Large acquired melanocytic nevi that occur in patients with epidermolysis bullosa (EB), referred to as EB nevi, may pose a diagnostic challenge because of their clinical and dermoscopic resemblance to melanoma.
  • These unconventional melanocytic nevi have been encountered in all categories of hereditary EB, most of them in childhood.
  • Although some of the reported cases have an alarming clinical appearance that is indistinguishable from melanoma, long-term follow-up has confirmed the benign nature of these rarely encountered melanocytic lesions.
  • OBSERVATION: We describe the clinical, dermoscopic, and histopathologic features of a large EB nevus in a toddler.
  • Histopathologically, a pattern of persistent melanocytic neoplasm was observed.
  • CONCLUSION: Epidermolysis bullosa nevi are dynamic melanocytic lesions that may simulate melanoma.
  • [MeSH-major] Dermoscopy. Melanoma / diagnosis. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis


67. Marques YM, de Lima Mde D, Raitz R, Pinto Ddos S Jr, de Sousa SO: Blue nevus: report of a case. Gen Dent; 2009 Jan-Feb;57(1):e1-3
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  • [Title] Blue nevus: report of a case.
  • Blue nevus is a benign, acquired melanocytic lesion that typically manifests as an asymptomatic, slate-blue or blue-black, smooth-surfaced macule or papule.
  • Intraoral melanocytic nevi are uncommon compared to those found in the skin, with the exception of the blue nevus.
  • The blue nevus is proportionally more prevalent in oral mucosa and represents the second most common form of nevus, accounting for 16.5% to 36% of all oral nevi.
  • This paper presents a case of common blue nevus of the hard palate in a 76-year-old woman, describes the clinical and histological aspects of the nevus, and discusses the difference between benign and malignant melanocytic lesion in the palate.
  • [MeSH-major] Mouth Mucosa / pathology. Mouth Neoplasms / pathology. Nevus, Blue / pathology. Skin Neoplasms / pathology

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  • (PMID = 21466995.001).
  • [ISSN] 0363-6771
  • [Journal-full-title] General dentistry
  • [ISO-abbreviation] Gen Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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68. Zalaudek I, Argenziano G, Mordente I, Moscarella E, Corona R, Sera F, Blum A, Cabo H, Di Stefani A, Hofmann-Wellenhof R, Johr R, Langford D, Malvehy J, Kolm I, Sgambato A, Puig S, Soyer HP, Kerl H: Nevus type in dermoscopy is related to skin type in white persons. Arch Dermatol; 2007 Mar;143(3):351-6
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  • [Title] Nevus type in dermoscopy is related to skin type in white persons.
  • BACKGROUND: Dermoscopic classification of acquired melanocytic nevi (AMN) is based on the evaluation of 3 main criteria-global pattern, pigment distribution, and color.
  • RESULTS: Of 680 included patients, dermoscopic analysis revealed significant differences in the prevalent nevus pattern in the 4 ST groups.
  • Light brown AMN with central hypopigmentation were associated with ST I, and ST IV was associated with the so-called black nevus (P<.001), typified by reticular pattern, central hyperpigmentation, and dark brown coloration.
  • CONCLUSIONS: The dermoscopic nevus type varies according to different ST in white people.
  • [MeSH-major] Dermoscopy. European Continental Ancestry Group. Nevus, Pigmented / classification. Nevus, Pigmented / pathology. Skin Neoplasms / classification. Skin Neoplasms / pathology

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  • (PMID = 17372099.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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69. Keijser S, Missotten GS, Bonfrer JM, de Wolff-Rouendaal D, Jager MJ, de Keizer RJ: Immunophenotypic markers to differentiate between benign and malignant melanocytic lesions. Br J Ophthalmol; 2006 Feb;90(2):213-7
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  • [Title] Immunophenotypic markers to differentiate between benign and malignant melanocytic lesions.
  • BACKGROUND/AIMS: The authors investigated the expression of S100A1, S100A6, S100B, MelanA, and CEA in conjunctival naevi, primary acquired melanosis (PAM), conjunctival melanoma, and uveal melanoma in order to assess their potential usefulness in the pathological differential diagnosis of these entities.
  • [MeSH-minor] Biomarkers / analysis. Carcinoembryonic Antigen / analysis. Cell Cycle Proteins / analysis. Conjunctival Neoplasms / diagnosis. Conjunctival Neoplasms / immunology. Diagnosis, Differential. Humans. Immunohistochemistry / methods. MART-1 Antigen. Melanoma / diagnosis. Melanoma / immunology. Melanosis / diagnosis. Melanosis / immunology. Neoplasm Proteins / analysis. Nerve Growth Factors / analysis. Nevus / diagnosis. Nevus / immunology. S100 Calcium Binding Protein beta Subunit. Uveal Neoplasms / diagnosis. Uveal Neoplasms / immunology

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  • (PMID = 16424536.001).
  • [ISSN] 0007-1161
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers; 0 / Carcinoembryonic Antigen; 0 / Cell Cycle Proteins; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Neoplasm Proteins; 0 / Nerve Growth Factors; 0 / S100 Calcium Binding Protein beta Subunit; 0 / S100 Proteins; 0 / S100A1 protein; 0 / S100B protein, human; 105504-00-5 / S100A6 protein, human
  • [Other-IDs] NLM/ PMC1860182
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70. Mahé E, Beauchet A, Aegerter P, Saiag P: Neonatal blue-light phototherapy does not increase nevus count in 9-year-old children. Pediatrics; 2009 May;123(5):e896-900
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  • [Title] Neonatal blue-light phototherapy does not increase nevus count in 9-year-old children.
  • OBJECTIVE: One of the most important risk factors for melanoma is the number of acquired common and atypical nevi in childhood.
  • The role played by neonatal blue-light phototherapy in the increasing incidence of common and atypical melanocytic nevi in childhood or adolescence has been discussed recently with discordant results.
  • PATIENTS AND METHODS: We designed a multicenter study to assess the effects of neonatal blue-light phototherapy on nevus count in a cohort of 9-year-old children.
  • History of neonatal phototherapy, phototype, skin, hair and eye color, and sunburn were assessed through questionnaires to which both parents and children responded, and a nevus count was performed by trained nurses blinded to phototherapy history.
  • RESULTS: Mean nevus count was 16.7 per child.
  • Neonatal phototherapy had no effect on the nevus count irrespective of nevi location, nevi size, or phototype of the children.
  • A light phototype, skin, and hair color; blue/green eyes; and history of sunburn were closely correlated with an increase in nevus count.
  • CONCLUSIONS: This study found no evidence for a major role of blue-light phototherapy on nevus count in 9-year-old children.
  • It underlines the dominant effect of phototype characteristics and history of sunburn in childhood on the early development of melanocytic nevi.
  • [MeSH-major] Nevus, Pigmented / epidemiology. Phototherapy. Skin Neoplasms / epidemiology

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  • (PMID = 19403483.001).
  • [ISSN] 1098-4275
  • [Journal-full-title] Pediatrics
  • [ISO-abbreviation] Pediatrics
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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71. Pache M, Glatz-Krieger K, Sauter G, Meyer P: Expression of sex hormone receptors and cell cycle proteins in melanocytic lesions of the ocular conjunctiva. Graefes Arch Clin Exp Ophthalmol; 2006 Jan;244(1):113-7
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  • [Title] Expression of sex hormone receptors and cell cycle proteins in melanocytic lesions of the ocular conjunctiva.
  • BACKGROUND: Both dermal and ocular melanocytic nevi have been reported to undergo changes during pregnancy.
  • We therefore set out to evaluate the expression of sex hormone receptors and cell cycle proteins in melanocytic lesions of the ocular conjunctiva.
  • METHODS: Formalin-fixed, paraffin-embedded material from 76 tumors--69 conjunctival nevi, 5 specimens of primary acquired melanosis (PAM), and 2 conjunctival melanomas--were included in a tissue microarray (TMA) format.
  • CONCLUSION: Our findings reveal the expression of progesterone, but not estrogen, in melanocytic lesions of the ocular conjunctiva.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cell Count. Child. Child, Preschool. Female. Humans. Immunohistochemistry. Male. Melanosis / metabolism. Middle Aged. Nevus, Pigmented / metabolism

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  • (PMID = 16003514.001).
  • [ISSN] 0721-832X
  • [Journal-full-title] Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie
  • [ISO-abbreviation] Graefes Arch. Clin. Exp. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Ki-67 Antigen; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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72. Novais GA, Fernandes BF, Belfort RN, Castiglione E, Cheema DP, Burnier MN Jr: Incidence of melanocytic lesions of the conjunctiva in a review of 10 675 ophthalmic specimens. Int J Surg Pathol; 2010 Feb;18(1):60-3
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  • [Title] Incidence of melanocytic lesions of the conjunctiva in a review of 10 675 ophthalmic specimens.
  • Of those, 271 were conjunctival lesions (2.5%), with 101 being classified as melanocytic: 50 (49.5%) nevi, 36 (35.6%) primary acquired melanoses, and 15 (14.9%) melanomas.
  • After exclusion of referred cases, 85 lesions were included in the study: 44 (51.7%) nevi, 33 (38.8%) primary acquired melanoses, and 8 (9.4%) melanomas.
  • Conjunctival melanomas were most commonly found in an older age group than primary acquired melanosis or nevi.
  • Primary acquired melanosis were further classified into primary acquired melanosis with atypia (8.2%) and primary acquired melanosis without atypia (30.5%).
  • Primary acquired melanoses was the predisposing lesion in 75% of the cases of melanoma.
  • [MeSH-major] Conjunctiva / pathology. Conjunctival Neoplasms / pathology. Melanoma / pathology. Melanosis / pathology. Nevus, Pigmented / pathology

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  • (PMID = 18611943.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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73. Seidenari S, Pellacani G, Martella A, Giusti F, Argenziano G, Buccini P, Carli P, Catricalà C, De Giorgi V, Ferrari A, Ingordo V, Manganoni AM, Peris K, Piccolo D, Pizzichetta MA: Instrument-, age- and site-dependent variations of dermoscopic patterns of congenital melanocytic naevi: a multicentre study. Br J Dermatol; 2006 Jul;155(1):56-61
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  • [Title] Instrument-, age- and site-dependent variations of dermoscopic patterns of congenital melanocytic naevi: a multicentre study.
  • BACKGROUND: Recently, we identified and described dermoscopic aspects, present with a higher frequency in congenital melanocytic lesions with respect to acquired naevi.
  • OBJECTIVES: Because the recognition of dermoscopic features may be instrument dependent, in this study, we wanted to check whether dermoscopic patterns specific for CN can be identified in digital images acquired by means of different instruments.
  • We also wanted to check the validity of our previously proposed classification and assess possible age- and site-dependent variations of dermoscopic patterns and naevus subtypes.
  • Lesion images were evaluated and checked for the presence of specific dermoscopic criteria, classified, and compared with a database of 350 acquired naevi.
  • RESULTS: Specific and unspecific dermoscopic features were identifiable in images acquired by means of all four instrument types.
  • The variegated naevus type was identified as a highly specific clinical/dermoscopic pattern.
  • Moreover, dermoscopy can be useful both for the classification of lesions already identified as congenital according to definite clinical and anamnestic data and for a possible correlation of naevus phenotype and dermoscopic patterns to the risk of developing a malignant melanoma in prospective studies.
  • [MeSH-major] Dermoscopy / instrumentation. Image Processing, Computer-Assisted. Nevus, Pigmented / pathology. Skin / pathology

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  • (PMID = 16792752.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] England
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74. Gallus S, Naldi L, Oncology Study Group of the Italian Group for Epidemiologic Research in Dermatology: Distribution of congenital melanocytic naevi and congenital naevus-like naevi in a survey of 3406 Italian schoolchildren. Br J Dermatol; 2008 Aug;159(2):433-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Distribution of congenital melanocytic naevi and congenital naevus-like naevi in a survey of 3406 Italian schoolchildren.
  • BACKGROUND: Scanty information is available on the prevalence of congenital melanocytic naevi (CMN) and congenital naevus-like naevi (CNLN), particularly the small ones.
  • CMN/CNLN were more frequent in children with a higher number of common melanocytic naevi (multivariate odds ratio, OR = 7.1 for the highest vs. the lowest quartile), consistent in small (OR = 7.2) and medium/large CMN/CNLN (OR = 6.0).
  • CONCLUSIONS: The association with family history of melanoma, the strong association with acquired melanocytic naevi, and the lack of association with pigmentary traits and sunburns suggest that CMN/CNLN may act as an independent risk marker for subjects at increased risk for cutaneous melanoma later in life.
  • [MeSH-major] Nevus / congenital. Nevus / epidemiology. Skin Neoplasms / congenital. Skin Neoplasms / epidemiology
  • [MeSH-minor] Adolescent. Child. Eye Color. Female. Hair Color. Humans. Italy / epidemiology. Male. Melanoma / epidemiology. Melanoma / genetics. Nevus, Pigmented / congenital. Nevus, Pigmented / epidemiology. Nevus, Pigmented / pathology. Prevalence. Risk Factors. Skin Pigmentation

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  • (PMID = 18547318.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Investigator] Leardini M; Feliciangeli M; Assalve D; Stingeni L; Stanganelli I; Magi S; Cusano F; Sarracco G; Di Landro A; Lo Scocco G; Di Lernia V; Tessari G; Fenizi G; Altobella A; Carli P; Nardini P; De Giorgi V; Pezzarossa E; Morelli R; Frassetto A; Cellini A; Simonetti O; Offidani A; Virgili A; Zampino MR; Villano P; Ausilia A; Ferraiolo S; Flaminio C; Tripodi-Cutri F; Filotico R; Lassandro ME
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75. Nino M, Brunetti B, Delfino S, Brunetti B, Panariello L, Russo D: Spitz nevus: follow-up study of 8 cases of childhood starburst type and proposal for management. Dermatology; 2009;218(1):48-51
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  • [Title] Spitz nevus: follow-up study of 8 cases of childhood starburst type and proposal for management.
  • Spitz nevus is an uncommon, benign melanocytic neoplasm that shares many clinical and histological features with melanoma.
  • We present our experience in the management of Spitz nevus by rigorous dermoscopic long-term follow-up of 8 Spitz nevi in patients younger than 12 years.
  • Dermoscopic images, acquired every 6 months, show evolution and modifications of these lesions.
  • [MeSH-major] Dermoscopy. Nevus, Epithelioid and Spindle Cell / pathology. Skin Neoplasms / pathology


76. Rubegni P, Sbano P, Burroni M, Cevenini G, Bocchi C, Severi FM, Risulo M, Petraglia F, Dell'Eva G, Fimiani M, Andreassi L: Melanocytic skin lesions and pregnancy: digital dermoscopy analysis. Skin Res Technol; 2007 May;13(2):143-7
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  • [Title] Melanocytic skin lesions and pregnancy: digital dermoscopy analysis.
  • Our purpose was to objectively determine, by digital dermoscopy analysis (DDA), any dermoscopic changes of acquired melanocitic nevi during pregnancy and after 1 year from delivery.
  • CONCLUSIONS: The study showed that pregnancy leads to significant modifications in PSL, especially with regard to pigment network, globules and architectural order or disorder.
  • [MeSH-major] Dermoscopy / methods. Image Interpretation, Computer-Assisted / methods. Nevus, Pigmented / pathology. Pregnancy Complications, Neoplastic / pathology. Signal Processing, Computer-Assisted. Skin / pathology. Skin Neoplasms / pathology

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  • (PMID = 17374054.001).
  • [ISSN] 0909-752X
  • [Journal-full-title] Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
  • [ISO-abbreviation] Skin Res Technol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Denmark
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77. Falchi M, Spector TD, Perks U, Kato BS, Bataille V: Genome-wide search for nevus density shows linkage to two melanoma loci on chromosome 9 and identifies a new QTL on 5q31 in an adult twin cohort. Hum Mol Genet; 2006 Oct 15;15(20):2975-9
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  • [Title] Genome-wide search for nevus density shows linkage to two melanoma loci on chromosome 9 and identifies a new QTL on 5q31 in an adult twin cohort.
  • The density of acquired melanocytic nevi represents an important risk factor for malignant melanoma.
  • Total body nevus counts were collected in a cross-sectional study of 1730 healthy females from the UK Adult twin registry comprising 709 dizygous and 156 monozygous pairs.
  • Nevus density (ND) increased up to the age of 35 years and then gradually declined.
  • They provide both novel and replicated QTLs for nevus development, some of which might overlap with those for melanoma and warrant detailed investigation.
  • [MeSH-major] Chromosomes, Human, Pair 5 / genetics. Chromosomes, Human, Pair 9 / genetics. Melanoma / genetics. Nevus / genetics. Quantitative Trait Loci. Skin Neoplasms / genetics


78. Patterson CR, Acland K, Khooshabeh R: Cutaneous malignant melanoma arising in an acquired naevus of Ota. Australas J Dermatol; 2009 Nov;50(4):294-6
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  • [Title] Cutaneous malignant melanoma arising in an acquired naevus of Ota.
  • Naevus of Ota is a dermal melanocytosis most commonly found in black or Asian skin and is usually a benign malformation, but with a low risk of melanoma.
  • We describe a 32-year-old Caucasian man with an acquired naevus of Ota with subtle pigmentation, in which a melanocytic papule developed.
  • [MeSH-major] Melanoma / pathology. Neoplasms, Second Primary / pathology. Nevus of Ota / pathology. Orbital Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 19916976.001).
  • [ISSN] 1440-0960
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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79. Ichii-Nakato N, Takata M, Takayanagi S, Takashima S, Lin J, Murata H, Fujimoto A, Hatta N, Saida T: High frequency of BRAFV600E mutation in acquired nevi and small congenital nevi, but low frequency of mutation in medium-sized congenital nevi. J Invest Dermatol; 2006 Sep;126(9):2111-8
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  • [Title] High frequency of BRAFV600E mutation in acquired nevi and small congenital nevi, but low frequency of mutation in medium-sized congenital nevi.
  • To investigate whether the frequency of the BRAF(V600E) (V-raf murine sarcoma virus oncogene homolog B1) mutation in melanocytic nevi is associated with sun exposure patterns, we examined 120 acquired melanocytic nevi excised from various anatomic sites, including glabrous skin, as well as 62 congenital nevi.
  • We detected the mutation in 105/120 (87.5%) acquired nevi and 43/62 (69.4%) congenital nevi.
  • Notably, we found the mutation in 35/43 (81.4%) acquired nevi excised from glabrous skin and genitalia.
  • Most of these nevi with wild-type BRAF had neroblastoma ras viral oncogene homolog mutations (9/14, 64.3%), suggesting different pathogenesis of medium-sized congenital nevi from acquired nevi and small congenital nevi.
  • [MeSH-major] Nevus / genetics. Point Mutation. Proto-Oncogene Proteins B-raf / genetics. Sunlight / adverse effects

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  • (PMID = 16691193.001).
  • [ISSN] 0022-202X
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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80. Oiso N, Kawara S, Kawada A: Acquired melanocytic naevus in naevus depigmentosus. Clin Exp Dermatol; 2009 Oct;34(7):e311-2
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  • [Title] Acquired melanocytic naevus in naevus depigmentosus.
  • [MeSH-major] Hypopigmentation / complications. Nevus, Pigmented / etiology. Skin Neoplasms / etiology

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  • (PMID = 19456784.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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81. De Panfilis G, Ferrari D, Santoro S, Ricci R, Lombardi M, Pedrazzi G, Pepe C, Cortelazzi C, Santini M: Cytoplasmic beta-catenin is lacking in a subset of melanoma-associated naevi, but is detectable in naevus-associated melanomas: potential implications for melanoma tumorigenesis? Br J Dermatol; 2009 Mar;160(3):600-8
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  • [Title] Cytoplasmic beta-catenin is lacking in a subset of melanoma-associated naevi, but is detectable in naevus-associated melanomas: potential implications for melanoma tumorigenesis?
  • OBJECTIVES: To investigate the role played in vivo by beta-catenin in melanoma tumorigenesis, we compared the cytoplasmic detection of beta-catenin in benign melanocytic cells vs. malignant melanoma cells presumably generated from these benign melanocytic cells.
  • For this purpose, melanocytic naevi occurring in association with melanoma, which were suggested to be melanoma precursors, were compared with their associated melanoma for beta-catenin cytoplasmic immunoreactivity.
  • METHODS: Fifty-seven consecutive cases of primary cutaneous melanoma were considered, and 15 of them were found to be associated with a melanocytic naevus portion.
  • The naevus portion showed features of acquired melanocytic naevus (total 12 cases: five dysplastic, seven intradermal) or congenital growth pattern naevus (total three cases: one superficial, two deep).
  • RESULTS: Virtually all primary cutaneous melanomas, including those associated with a naevus portion, showed cytoplasmic beta-catenin positivity.
  • However, the intradermal naevus portion was consistently cytoplasmic beta-catenin negative, while both the dysplastic and the congenital naevus portions were cytoplasmic beta-catenin positive.
  • CONCLUSIONS: Beta-catenin excess may play a role in melanoma tumorigenesis, because beta-catenin cytoplasmic reactivity was found in primary cutaneous melanoma but not in its associated intradermal naevus precursor.
  • As, however, beta-catenin cytoplasmic reactivity was detected not only in primary cutaneous melanoma but also in its associated dysplastic/congenital naevus precursors, beta-catenin stabilization alone is not sufficient to play a decisive role for melanoma onset.
  • [MeSH-major] Cell Transformation, Neoplastic / metabolism. Melanoma / metabolism. Nevus, Pigmented / metabolism. Skin Neoplasms / metabolism. beta Catenin / metabolism

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  • (PMID = 19183173.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / beta Catenin
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82. Murali R, McCarthy SW, Scolyer RA: Blue nevi and related lesions: a review highlighting atypical and newly described variants, distinguishing features and diagnostic pitfalls. Adv Anat Pathol; 2009 Nov;16(6):365-82
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  • Blue nevi and related entities are a heterogenous group of congenital and acquired melanocytic tumors that includes established entities such as dendritic ("common") blue nevus and cellular blue nevus, and their numerous clinical and pathologic variants, such as deep penetrating nevus.
  • They share several clinical and morphologic features including their blue tinctorial properties, the presence of a dermal proliferation of spindle, fusiform or ovoid cells, associated melanin pigment (both within the melanocytic tumor cells and also within macrophages) and stromal sclerosis and, at least focal positivity for HMB-45 (Gp100).
  • Some variants, such as deep penetrating nevus, often show considerable variation in nuclear size and shape, and, as a consequence, are at risk of being misdiagnosed as melanoma by those unfamiliar with their characteristic morphologic features.
  • The so-called malignant blue nevus is a controversial term denoting melanomas arising in association with or exhibiting some morphologic similarities to blue nevus.
  • [MeSH-major] Nevus, Blue / pathology. Skin Neoplasms / pathology

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  • (PMID = 19851128.001).
  • [ISSN] 1533-4031
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Melanins
  • [Number-of-references] 193
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83. Jen M, Murphy M, Grant-Kels JM: Childhood melanoma. Clin Dermatol; 2009 Nov-Dec;27(6):529-36
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  • Some risk factors for melanoma include xeroderma pigmentosum, giant congenital melanocytic nevi, dysplastic nevus syndrome, atypical nevi, many acquired melanocytic nevi, family history of melanoma, and immunosuppression.
  • [MeSH-major] Melanoma / pathology. Neoplasm Invasiveness / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • (PMID = 19880040.001).
  • [ISSN] 1879-1131
  • [Journal-full-title] Clinics in dermatology
  • [ISO-abbreviation] Clin. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 117
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84. Elder DE: Precursors to melanoma and their mimics: nevi of special sites. Mod Pathol; 2006 Feb;19 Suppl 2:S4-20
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  • Melanocytic nevi, which are benign tumors of melanocytes, may have occasional cosmetic significance but, for the most part, they are important only in relation to melanoma.
  • Dysplastic nevi and, to a lesser extent, common acquired and congenital nevi are among the most important melanoma risk markers.
  • Nevi of special sites have been identified as nevi that may show atypical features suggestive of a dysplastic nevus or of a melanoma.
  • It is important, in considering the differential diagnosis of a lesion in a special site, to avoid overcalling such a lesion as a melanoma or a dysplastic nevus because this could lead to excessive treatment.
  • Conversely, it is important to avoid undercalling a lesion that is a dysplastic nevus or a melanoma as a nevus of special sites, because in this circumstance a patient could lose the opportunity either for surveillance to recognize a developing melanoma at an early, curable stage, or for definitive treatment of an established malignancy.
  • [MeSH-major] Dysplastic Nevus Syndrome / pathology. Melanoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Melanocytes / pathology. Nevus, Pigmented / pathology

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  • (PMID = 16446715.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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85. Krengel S: Nevogenesis--new thoughts regarding a classical problem. Am J Dermatopathol; 2005 Oct;27(5):456-65
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  • The development of melanocytic nevi is a multifactorial and heterogeneous biologic process that involves prenatal and postnatal steps.
  • In this review, dermatopathological studies on congenital and acquired nevi, including studies on age-related and location-dependent changes, are analyzed.
  • Regarding the mechanisms of postnatal nevus development, epidemiological studies demonstrate the importance of constitutional and environmental influences, especially ultraviolet light.
  • [MeSH-major] Cell Transformation, Neoplastic. Nevus / physiopathology. Skin Neoplasms / physiopathology

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  • (PMID = 16148419.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 89
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86. Pellacani G, Grana C, Seidenari S: Algorithmic reproduction of asymmetry and border cut-off parameters according to the ABCD rule for dermoscopy. J Eur Acad Dermatol Venereol; 2006 Nov;20(10):1214-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Three hundred and thirty-one melanocytic lesion images, referring to 113 melanomas and 218 melanocytic nevi, acquired by means of a digital videodermatoscope, were considered.
  • Differences between nevus and melanoma values were evaluated using the chi-square test, while Cohen's Kappa index for agreement was employed for the evaluation of the concordance between human and computer.
  • [MeSH-minor] Dermoscopy. Humans. Image Processing, Computer-Assisted / methods. Microscopy, Video. Nevus, Pigmented / diagnosis

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  • (PMID = 17062034.001).
  • [ISSN] 0926-9959
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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87. Jakobiec FA, Bhat P, Colby KA: Immunohistochemical studies of conjunctival nevi and melanomas. Arch Ophthalmol; 2010 Feb;128(2):174-83
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  • OBJECTIVE: To evaluate the role of immunohistochemical methods in the diagnosis of benign and malignant conjunctival melanocytic proliferations.
  • Melanomas in situ and atypical primary acquired melanoses had more than twice the Ki-67 proliferation counts of intraepithelial junctional nevocytes (P < .001) and more intense HMB-45 cytoplasmic staining than junctional zone nevocytes.
  • Results for nevus cells beneath the junctional zone were overwhelmingly negative for HMB-45 and Ki-67.
  • Immunostaining for HMB-45 and Ki-67 are valuable adjuncts to careful histopathologic evaluation in assessing benign and malignant conjunctival melanocytic tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. Conjunctival Neoplasms / diagnosis. Melanoma / diagnosis. Neoplasm Proteins / analysis. Nevus, Pigmented / diagnosis

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  • (PMID = 20142539.001).
  • [ISSN] 1538-3601
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins; EC 3.1.3.48 / Antigens, CD45; EC 3.1.3.48 / PTPRC protein, human
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88. Schaffer JV: Pigmented lesions in children: when to worry. Curr Opin Pediatr; 2007 Aug;19(4):430-40
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  • It is therefore important for pediatricians to be aware of the natural history and clinical spectrum of melanocytic nevi in children as well as potentially worrisome features of pigmented lesions.
  • RECENT FINDINGS: Recent studies have provided insight into the development, evolution and molecular bases of acquired and congenital melanocytic nevi during childhood.
  • This review summarizes the types of melanocytic nevi that are commonly observed in children, environmental (e.g. sun exposure) and genetic (e.g. the familial atypical mole and melanoma syndrome) factors that can contribute to the development of nevi and future risk of melanoma, and phenotypic markers (e.g. numerous acquired nevi or the 'red hair phenotype') that signal the need for periodic total-body cutaneous examinations.
  • Current concepts of the risks associated with congenital melanocytic nevi of different sizes and strategies for the management of various types of nevi (including congenital, blue and Spitz nevi) are presented, and data on the clinical presentations and biologic behavior of prepubertal melanoma are discussed.
  • SUMMARY: Clinical and molecular investigations have helped to better understand the characteristics of melanocytic nevi and define pathways of melanocytic tumorigenesis.
  • [MeSH-major] Nevus, Pigmented / diagnosis
  • [MeSH-minor] Child. Diagnosis, Differential. Humans. Melanoma / diagnosis. Melanoma / genetics. Melanoma / surgery. Nevus, Blue / diagnosis. Nevus, Blue / surgery. Nevus, Epithelioid and Spindle Cell / diagnosis. Nevus, Epithelioid and Spindle Cell / surgery. Skin Neoplasms / diagnosis. Skin Neoplasms / genetics. Skin Neoplasms / surgery

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  • (PMID = 17630608.001).
  • [ISSN] 1040-8703
  • [Journal-full-title] Current opinion in pediatrics
  • [ISO-abbreviation] Curr. Opin. Pediatr.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 100
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89. Pellacani G, Cesinaro AM, Seidenari S: Reflectance-mode confocal microscopy of pigmented skin lesions--improvement in melanoma diagnostic specificity. J Am Acad Dermatol; 2005 Dec;53(6):979-85
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  • OBJECTIVE: We sought to describe confocal features in melanocytic lesions and to evaluate their diagnostic significance for melanoma (MM) identification.
  • METHODS: Thirty seven MMs, 49 acquired nevi, and 16 Spitz/Reed nevi, presenting equivocal clinicodermoscopic aspects were investigated by confocal microscopy.
  • CONCLUSION: Characterization of confocal microscopy features of MMs and nevi seems to improve diagnostic accuracy for melanocytic lesions that are difficult to diagnose.
  • [MeSH-major] Hyperpigmentation / pathology. Melanoma / pathology. Microscopy, Confocal. Nevus, Epithelioid and Spindle Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 16310058.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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90. Pellacani G, Cesinaro AM, Longo C, Grana C, Seidenari S: Microscopic in vivo description of cellular architecture of dermoscopic pigment network in nevi and melanomas. Arch Dermatol; 2005 Feb;141(2):147-54
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  • DESIGN: Confocal imaging was performed on melanocytic lesions characterized by pigment network at dermoscopy.
  • On the other hand, common acquired nevi were characterized by lack of atypical cells and edged dermal papillae.
  • [MeSH-major] Melanoma / pathology. Microscopy, Confocal. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • [CommentIn] Arch Dermatol. 2005 Feb;141(2):212-5 [15724018.001]
  • (PMID = 15724010.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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91. Wagner N, Panelos J, Massi D, Wagner KD: The Wilms' tumor suppressor WT1 is associated with melanoma proliferation. Pflugers Arch; 2008 Feb;455(5):839-47
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  • In this paper, we show that WT1 is expressed in malignant melanoma in >80% of the tumor cells, but not in normal skin or benign melanocytic nevi in vivo.
  • Furthermore, expression of WT1 in vivo clearly discriminates between benign acquired nevi and malignant melanomas and appears to be correlated with melanocytic atypia and malignancy.
  • [MeSH-minor] Apoptosis / physiology. Biomarkers, Tumor / metabolism. Cell Division / physiology. Cell Line, Tumor. Cytoskeletal Proteins / metabolism. Gene Expression Regulation, Neoplastic. Glycoproteins / metabolism. Humans. Intermediate Filament Proteins / metabolism. Keratinocytes / physiology. Melanocytes / physiology. Nerve Tissue Proteins / metabolism. Nestin. Nevus, Pigmented / metabolism. Nevus, Pigmented / pathology. Nevus, Pigmented / physiopathology. RNA Interference. Transfection. Zyxin

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  • (PMID = 17912546.001).
  • [ISSN] 0031-6768
  • [Journal-full-title] Pflügers Archiv : European journal of physiology
  • [ISO-abbreviation] Pflugers Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cytoskeletal Proteins; 0 / Glycoproteins; 0 / Intermediate Filament Proteins; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin; 0 / WT1 Proteins; 0 / ZYX protein, human; 0 / Zyxin
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92. Vabres P: [What's new in pediatric dermatology?]. Ann Dermatol Venereol; 2008 Dec;135 Suppl 7:S343-53
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  • The main selected articles in pediatric dermatology covered the following topics: development and maturation of the epidermal barrier in the neonate, iatrogenic events in the neonatal ICU, diagnostic value of minor birthmarks, complications, risk factors and treatment of hemangiomas, coagulopathy in venous malformations, epidemiology and dermoscopy of congenital and acquired melanocytic nevi in childhood, growth of the body surface area, new pathogenic concepts and treatment in atopic dermatitis, the impact of filaggrin deficiency, hereditary factors in Kawasaki disease, severe and drug resistant cases, management of juvenile dermatomyositis, treatment of childhood psoriasis with biologics, the new classification of epidermolysis bullosa and therapeutic approach with cell therapy, neurological impairment in xeroderma pigmentosum, behavioural anomalies in X-linked ichthyosis, guidelines for neurofibromatosis type I, the genetics of an hereditary hypotrichosis, infantile acne, rosacea in childhood, mast cell disease management and, last but not least, treatment of hair lice with silicone.
  • [MeSH-minor] Acne Vulgaris / drug therapy. Acne Vulgaris / genetics. Child. Dermatitis, Atopic / drug therapy. Dermatitis, Atopic / genetics. Dermatomyositis / drug therapy. Dermatomyositis / genetics. Epidermolysis Bullosa / drug therapy. Epidermolysis Bullosa / genetics. Hemangioma / drug therapy. Hemangioma / genetics. Humans. Hypotrichosis / drug therapy. Hypotrichosis / genetics. Ichthyosis / drug therapy. Ichthyosis / genetics. Mastocytosis / drug therapy. Mastocytosis / genetics. Mucocutaneous Lymph Node Syndrome / drug therapy. Mucocutaneous Lymph Node Syndrome / genetics. Neurofibromatosis 1 / drug therapy. Neurofibromatosis 1 / genetics. Nevus, Pigmented / drug therapy. Nevus, Pigmented / genetics. Psoriasis / drug therapy. Psoriasis / genetics. Risk Factors. Rosacea / drug therapy. Rosacea / genetics. Xeroderma Pigmentosum / drug therapy. Xeroderma Pigmentosum / genetics

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  • (PMID = 19264210.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Dermatologic Agents
  • [Number-of-references] 90
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93. Cardones AR, Grichnik JM: alpha-Melanocyte-stimulating hormone-induced eruptive nevi. Arch Dermatol; 2009 Apr;145(4):441-4
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  • The preexisting nevi became darker and acquired growth features.
  • CONCLUSIONS: Synthetic alpha-MSH peptides can drive proliferation of neoplastic melanocytic cells in predisposed patients.
  • [MeSH-major] Nevus, Pigmented / chemically induced. Peptides, Cyclic / adverse effects. Skin Neoplasms / chemically induced. alpha-MSH / analogs & derivatives

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  • (PMID = 19380666.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Peptides, Cyclic; 121062-08-6 / melanotan-II; 581-05-5 / alpha-MSH
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94. Prat Acín R, Galeano I: Giant occipital intradiploic epidermoid cyst associated with iatrogenic puncture. Acta Neurochir (Wien); 2008 Apr;150(4):413-4
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  • The origin of cranial epidermoid cysts (EC) remains controversial, and although generally considered to be congenital, acquired origin has been reported.
  • Three years previously, in the same location, she underwent resection of an intradermal melanocytic naevus of the skin under local anaesthesia with lidocaine infiltration of skin and periosteum.
  • Brain CT scan performed at the time of naevus surgery because of associated headache did not show a lesion of the cranial vault.
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Nevus, Pigmented / surgery. Reoperation. Scalp / surgery. Skin Neoplasms / surgery. Tomography, X-Ray Computed

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  • (PMID = 18301860.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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95. Deichmann M, Thome M, Egner U, Hartschuh W, Kurzen H: The chemoresistance gene ABCG2 (MXR/BCRP1/ABCP1) is not expressed in melanomas but in single neuroendocrine carcinomas of the skin. J Cutan Pathol; 2005 Aug;32(7):467-73
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  • METHODS AND RESULTS: Upon semiquantitative reverse transcription polymerase chain reaction, ABCG2 mRNA expression was not upregulated in 18 melanoma resection specimens when compared with 19 acquired melanocytic nevi from which melanomas are known to often arise (Mantel-Haenszel test, p=0.3).
  • At protein level, immunohistochemistry was negative in all 66 investigated melanoma resection specimens (50 primary melanomas and 16 cutaneous/subcutaneous metastases) and in 19 acquired melanocytic nevi.
  • [MeSH-minor] Humans. Immunoenzyme Techniques. Nevus, Pigmented / genetics. Nevus, Pigmented / metabolism. Nevus, Pigmented / pathology. RNA, Messenger / metabolism. RNA, Neoplasm / analysis. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 16008690.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / ABCG2 protein, human; 0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / RNA, Neoplasm
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96. Hammes S, Raulin C, Karsai S, Bernt R, Ockenfels HM: [Treating papillomatous intradermal nevi: lasers - yes or no? A prospective study]. Hautarzt; 2008 Feb;59(2):101-7
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  • BACKGROUND: Papillomatous intradermal nevi are common acquired melanocytic nevi.
  • [MeSH-major] Low-Level Light Therapy / methods. Melanosis / radiotherapy. Nevus, Pigmented / radiotherapy. Papilloma / radiotherapy. Skin Neoplasms / radiotherapy

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  • (PMID = 18219471.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Clinical Trial; English Abstract; Journal Article
  • [Publication-country] Germany
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97. Damato B, Coupland SE: Management of conjunctival melanoma. Expert Rev Anticancer Ther; 2009 Sep;9(9):1227-39
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  • Invasive conjunctival melanoma can arise de novo, from nevus or from melanoma in situ.
  • We propose that the term 'primary acquired melanosis' should only be used clinically, when the histology is not known.
  • We have devised a clinical system for mapping conjunctival melanocytic lesions and a system for scoring the histological grade of atypia of conjunctival melanocytic intra-epithelial neoplasia/melanoma in situ.

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  • (PMID = 19761427.001).
  • [ISSN] 1744-8328
  • [Journal-full-title] Expert review of anticancer therapy
  • [ISO-abbreviation] Expert Rev Anticancer Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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98. Itakura E, Huang RR, Wen DR, Paul E, Wünsch PH, Cochran AJ: RT in situ PCR detection of MART-1 and TRP-2 mRNA in formalin-fixed, paraffin-embedded tissues of melanoma and nevi. Mod Pathol; 2008 Mar;21(3):326-33
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  • Melanoma antigen recognized by T cells 1 (MART-1) and tyrosinase-related protein-2 (TRP-2) are two useful markers for immunohistochemical detection of melanocytic tumors.
  • However, these markers may be passively acquired (phagocytosed) rather than actively synthesized.
  • [MeSH-major] Antigens, Neoplasm / genetics. Intramolecular Oxidoreductases / genetics. Melanoma / genetics. Neoplasm Proteins / genetics. Nevus / genetics. Polymerase Chain Reaction / methods. Skin Neoplasms / genetics

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  • (PMID = 18204435.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P01 CA 29605
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 1HG84L3525 / Formaldehyde; EC 5.3.- / Intramolecular Oxidoreductases; EC 5.3.3.12 / dopachrome isomerase
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99. Bongiorno MR, Lodato G, Affronti A, Aragona F, Aricò M: Amelanotic conjunctival melanoma. Cutis; 2006 Jun;77(6):377-81
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  • We describe a 32-year-old white man with an amelanotic malignant melanoma of the conjunctiva that is not associated with primary acquired melanosis (PAM) or melanocytic nevus.

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  • (PMID = 16838771.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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100. Nakamura Y, Kambe N, Deguchi N, Kawamura T, Shibagaki N, Matsue H, Shimada S: Agminated acquired melanocytic naevus modified by vitiligo vulgaris arising in the elderly. Clin Exp Dermatol; 2009 Oct;34(7):e377-8
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  • [Title] Agminated acquired melanocytic naevus modified by vitiligo vulgaris arising in the elderly.
  • [MeSH-major] Breast Neoplasms / diagnosis. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis. Vitiligo / complications






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