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1. Hofmann UB, Bröcker EB, Hamm H: Simultaneous onset of segmental vitiligo and a halo surrounding a congenital melanocytic naevus. Acta Derm Venereol; 2009;89(4):402-6
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  • [Title] Simultaneous onset of segmental vitiligo and a halo surrounding a congenital melanocytic naevus.
  • Unlike in common melanocytic naevi, an acquired leukoderma (halo) surrounding a congenital melanocytic naevus is a rare phenomenon.
  • A 6-year-old boy developed a depigmentation around a congenital melanocytic naevus on the right thigh.
  • The simultaneous occurrence of a halo phenomenon around a congenital melanocytic naevus and segmental vitiligo, as well as identical histological and immunohistological findings in both pigmented lesions, suggest shared immunological mechanisms.
  • [MeSH-major] Nevus, Pigmented / immunology. Skin Neoplasms / immunology. Skin Pigmentation / immunology. Vitiligo / immunology

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  • (PMID = 19688155.001).
  • [ISSN] 1651-2057
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Neoplasm Proteins
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2. Corradin MT, Alaibac M, Fortina AB: A case of malignant melanoma arising from an acquired agminated melanocytic naevus. Acta Derm Venereol; 2007;87(5):432-3
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  • [Title] A case of malignant melanoma arising from an acquired agminated melanocytic naevus.
  • [MeSH-major] Melanoma / pathology. Neoplasms, Second Primary / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • (PMID = 17721654.001).
  • [ISSN] 0001-5555
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Sweden
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3. Nakamura Y, Kambe N, Deguchi N, Kawamura T, Shibagaki N, Matsue H, Shimada S: Agminated acquired melanocytic naevus modified by vitiligo vulgaris arising in the elderly. Clin Exp Dermatol; 2009 Oct;34(7):e377-8
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  • [Title] Agminated acquired melanocytic naevus modified by vitiligo vulgaris arising in the elderly.
  • [MeSH-major] Breast Neoplasms / diagnosis. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis. Vitiligo / complications

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  • (PMID = 19486045.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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4. De Panfilis G, Ferrari D, Santoro S, Ricci R, Lombardi M, Pedrazzi G, Pepe C, Cortelazzi C, Santini M: Cytoplasmic beta-catenin is lacking in a subset of melanoma-associated naevi, but is detectable in naevus-associated melanomas: potential implications for melanoma tumorigenesis? Br J Dermatol; 2009 Mar;160(3):600-8
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  • [Title] Cytoplasmic beta-catenin is lacking in a subset of melanoma-associated naevi, but is detectable in naevus-associated melanomas: potential implications for melanoma tumorigenesis?
  • OBJECTIVES: To investigate the role played in vivo by beta-catenin in melanoma tumorigenesis, we compared the cytoplasmic detection of beta-catenin in benign melanocytic cells vs. malignant melanoma cells presumably generated from these benign melanocytic cells.
  • For this purpose, melanocytic naevi occurring in association with melanoma, which were suggested to be melanoma precursors, were compared with their associated melanoma for beta-catenin cytoplasmic immunoreactivity.
  • METHODS: Fifty-seven consecutive cases of primary cutaneous melanoma were considered, and 15 of them were found to be associated with a melanocytic naevus portion.
  • The naevus portion showed features of acquired melanocytic naevus (total 12 cases: five dysplastic, seven intradermal) or congenital growth pattern naevus (total three cases: one superficial, two deep).
  • RESULTS: Virtually all primary cutaneous melanomas, including those associated with a naevus portion, showed cytoplasmic beta-catenin positivity.
  • However, the intradermal naevus portion was consistently cytoplasmic beta-catenin negative, while both the dysplastic and the congenital naevus portions were cytoplasmic beta-catenin positive.
  • CONCLUSIONS: Beta-catenin excess may play a role in melanoma tumorigenesis, because beta-catenin cytoplasmic reactivity was found in primary cutaneous melanoma but not in its associated intradermal naevus precursor.
  • As, however, beta-catenin cytoplasmic reactivity was detected not only in primary cutaneous melanoma but also in its associated dysplastic/congenital naevus precursors, beta-catenin stabilization alone is not sufficient to play a decisive role for melanoma onset.
  • [MeSH-major] Cell Transformation, Neoplastic / metabolism. Melanoma / metabolism. Nevus, Pigmented / metabolism. Skin Neoplasms / metabolism. beta Catenin / metabolism

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  • (PMID = 19183173.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / beta Catenin
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5. Zalaudek I, Grinschgl S, Argenziano G, Marghoob AA, Blum A, Richtig E, Wolf IH, Fink-Puches R, Kerl H, Soyer HP, Hofmann-Wellenhof R: Age-related prevalence of dermoscopy patterns in acquired melanocytic naevi. Br J Dermatol; 2006 Feb;154(2):299-304
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  • [Title] Age-related prevalence of dermoscopy patterns in acquired melanocytic naevi.
  • BACKGROUND: Based on the dermoscopic classification of acquired melanocytic naevi, six different dermoscopic types can be distinguished by morphology (globular, globular-reticular, globular-homogeneous, reticular, reticular-homogeneous, homogeneous) and by pigment distribution (uniform, central hyperpigmentation, central hypopigmentation, peripheral hyperpigmentation, peripheral hypopigmentation, multifocal hyper/hypopigmentation).
  • OBJECTIVES: To evaluate whether the age of the patient influences the predominant naevus pattern observed in individuals with multiple acquired melanocytic naevi.
  • Individuals with at least 10 melanocytic naevi were selected consecutively until a total of 10 individuals in each of five age groups was obtained.
  • Digitized images of acquired melanocytic naevi, defined as benign melanocytic proliferations having a diameter of at least 5 mm with a macular component and which were not apparent within the first year of life, were evaluated by dermoscopic criteria.
  • Uniform pigmentation was most common in melanocytic naevi in the youngest age group, while central hyperpigmentation was predominantly seen in the group of individuals aged 16-30 years.
  • CONCLUSIONS: The predominance of dermoscopic types of melanocytic naevi varies according to the individual's age.
  • Awareness of the age-related dermoscopic predominance of melanocytic naevi might allow more accurate recognition of dermoscopic patterns of melanocytic skin lesions that are unusual with respect to the individual's age.
  • Furthermore, the observations made in this study raise interesting questions regarding naevus evolution.
  • [MeSH-major] Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • (PMID = 16433800.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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6. Lebeau S, Braun RP, Masouyé I, Perrinaud A, Harms M, Borradori L: Acquired melanocytic naevus in childhood vulval pemphigoid. Dermatology; 2006;213(2):159-62
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  • [Title] Acquired melanocytic naevus in childhood vulval pemphigoid.
  • BACKGROUND: Eruptive epidermolysis bullosa (EB) naevi comprise a subset of melanocytic naevi with atypical features that characteristically occur in areas of former blistering in patients suffering from hereditary EB.
  • In the course of the disease, she developed an atypical melanocytic naevus on the left labium at a site of former blistering.
  • CONCLUSION: This is the first report describing the development of a melanocytic naevus at sites of blistering in an auto-immune subepidermal blistering disease in childhood.
  • Our observation extends the spectrum of disorders, in addition to the group of congenital EB, in which 'eruptive' atypical melanocytic naevi may occur.
  • [MeSH-major] Nevus, Pigmented / complications. Pemphigoid, Bullous / complications. Skin Neoplasms / complications. Vulvar Diseases / complications

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  • [Copyright] Copyright 2006 S. Karger AG, Basel.
  • (PMID = 16902297.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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7. Palleschi GM, Cipollini EM, Torchia D, Torre E, Urso C: Fibrillar pattern of a plantar acquired melanocytic naevus: correspondence between epiluminescence microscopy and transverse section histology. Clin Exp Dermatol; 2006 May;31(3):449-51
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  • [Title] Fibrillar pattern of a plantar acquired melanocytic naevus: correspondence between epiluminescence microscopy and transverse section histology.
  • The main epiluminescence microscopy (ELM) patterns observed on volar acquired melanocytic naevi are the parallel-furrow, the lattice-like and the fibrillar patterns.
  • To clarify the microscopic features of the fibrillar pattern, we used transverse histological sectioning to study an acquired compound melanocytic naevus of the sole, characterized by a mixed parallel-furrow/fibrillar pattern on ELM.
  • [MeSH-major] Foot Diseases / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • [CommentIn] Clin Exp Dermatol. 2007 Jan;32(1):103 [16939585.001]
  • (PMID = 16681598.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] England
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8. Oiso N, Kawara S, Kawada A: Acquired melanocytic naevus in naevus depigmentosus. Clin Exp Dermatol; 2009 Oct;34(7):e311-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acquired melanocytic naevus in naevus depigmentosus.
  • [MeSH-major] Hypopigmentation / complications. Nevus, Pigmented / etiology. Skin Neoplasms / etiology

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  • (PMID = 19456784.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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9. Patterson CR, Acland K, Khooshabeh R: Cutaneous malignant melanoma arising in an acquired naevus of Ota. Australas J Dermatol; 2009 Nov;50(4):294-6
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  • [Title] Cutaneous malignant melanoma arising in an acquired naevus of Ota.
  • Naevus of Ota is a dermal melanocytosis most commonly found in black or Asian skin and is usually a benign malformation, but with a low risk of melanoma.
  • We describe a 32-year-old Caucasian man with an acquired naevus of Ota with subtle pigmentation, in which a melanocytic papule developed.
  • [MeSH-major] Melanoma / pathology. Neoplasms, Second Primary / pathology. Nevus of Ota / pathology. Orbital Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 19916976.001).
  • [ISSN] 1440-0960
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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10. Gallus S, Naldi L, Oncology Study Group of the Italian Group for Epidemiologic Research in Dermatology: Distribution of congenital melanocytic naevi and congenital naevus-like naevi in a survey of 3406 Italian schoolchildren. Br J Dermatol; 2008 Aug;159(2):433-8
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  • [Title] Distribution of congenital melanocytic naevi and congenital naevus-like naevi in a survey of 3406 Italian schoolchildren.
  • BACKGROUND: Scanty information is available on the prevalence of congenital melanocytic naevi (CMN) and congenital naevus-like naevi (CNLN), particularly the small ones.
  • CMN/CNLN were more frequent in children with a higher number of common melanocytic naevi (multivariate odds ratio, OR = 7.1 for the highest vs. the lowest quartile), consistent in small (OR = 7.2) and medium/large CMN/CNLN (OR = 6.0).
  • CONCLUSIONS: The association with family history of melanoma, the strong association with acquired melanocytic naevi, and the lack of association with pigmentary traits and sunburns suggest that CMN/CNLN may act as an independent risk marker for subjects at increased risk for cutaneous melanoma later in life.
  • [MeSH-major] Nevus / congenital. Nevus / epidemiology. Skin Neoplasms / congenital. Skin Neoplasms / epidemiology
  • [MeSH-minor] Adolescent. Child. Eye Color. Female. Hair Color. Humans. Italy / epidemiology. Male. Melanoma / epidemiology. Melanoma / genetics. Nevus, Pigmented / congenital. Nevus, Pigmented / epidemiology. Nevus, Pigmented / pathology. Prevalence. Risk Factors. Skin Pigmentation

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  • (PMID = 18547318.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Investigator] Leardini M; Feliciangeli M; Assalve D; Stingeni L; Stanganelli I; Magi S; Cusano F; Sarracco G; Di Landro A; Lo Scocco G; Di Lernia V; Tessari G; Fenizi G; Altobella A; Carli P; Nardini P; De Giorgi V; Pezzarossa E; Morelli R; Frassetto A; Cellini A; Simonetti O; Offidani A; Virgili A; Zampino MR; Villano P; Ausilia A; Ferraiolo S; Flaminio C; Tripodi-Cutri F; Filotico R; Lassandro ME
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11. Perra MT, Colombari R, Maxia C, Zucca I, Piras F, Corbu A, Bravo S, Scarpa A, Sirigu P: Finding of conjunctival melanocytic pigmented lesions within pterygium. Histopathology; 2006 Mar;48(4):387-93

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  • [Title] Finding of conjunctival melanocytic pigmented lesions within pterygium.
  • Melanocytic pigmented lesions commonly occur in the conjunctiva, although they have not been previously reported in pterygium, a common lesion which originates from conjunctiva.
  • Our aim was to evaluate the possibility of an association between pterygium and conjunctival melanocytic pigmented lesions.
  • Histological sections were evaluated for the presence of melanocytic pigmented lesions.
  • Nine cases of conjunctival melanocytic, pigmented lesions within pterygium were found and were classified according to the histopathological criteria previously published for pigmented lesions of the conjunctiva, as naevi and primary acquired melanosis (PAM) with varying degrees of atypia.
  • Five of the nine cases showed primary acquired melanosis without atypia, while two cases had atypia; one case showed features of compound naevus and one lesion was designated as subepithelial naevus.
  • CONCLUSIONS: Our findings suggest that conjunctival melanocytic, pigmented lesions occasionally occur in pterygium.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Melanosis / pathology. Nevus, Pigmented / pathology. Pterygium / pathology

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  • (PMID = 16487360.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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12. Maly A, Epstein D, Meir K, Pe'er J: Histological criteria for grading of atypia in melanocytic conjunctival lesions. Pathology; 2008 Dec;40(7):676-81
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  • [Title] Histological criteria for grading of atypia in melanocytic conjunctival lesions.
  • AIMS: To develop a standardised protocol for grading atypia in melanocytic conjunctival lesions (MCL), mainly primary acquired melanosis (PAM) and inflamed juvenile conjunctival naevi (IJCN) and to establish prognostic parameters for progression to malignant melanoma (MM).
  • Histological slides of MCL diagnosed as conjunctival naevus (CN; 222 cases), PAM (42 cases), and IJCN (40 cases) were reviewed.
  • A scoring method of atypia was developed according to the following histological parameters: nest cohesion, melanocytic hyperplasia, nuclear features, and pagetoid spread.
  • IJCN cases showed architectural disorder only.
  • Neither architectural disorder nor cytological atypia were found in the CN.

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  • (PMID = 18985522.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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13. Seidenari S, Pellacani G, Martella A, Giusti F, Argenziano G, Buccini P, Carli P, Catricalà C, De Giorgi V, Ferrari A, Ingordo V, Manganoni AM, Peris K, Piccolo D, Pizzichetta MA: Instrument-, age- and site-dependent variations of dermoscopic patterns of congenital melanocytic naevi: a multicentre study. Br J Dermatol; 2006 Jul;155(1):56-61

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  • [Title] Instrument-, age- and site-dependent variations of dermoscopic patterns of congenital melanocytic naevi: a multicentre study.
  • BACKGROUND: Recently, we identified and described dermoscopic aspects, present with a higher frequency in congenital melanocytic lesions with respect to acquired naevi.
  • OBJECTIVES: Because the recognition of dermoscopic features may be instrument dependent, in this study, we wanted to check whether dermoscopic patterns specific for CN can be identified in digital images acquired by means of different instruments.
  • We also wanted to check the validity of our previously proposed classification and assess possible age- and site-dependent variations of dermoscopic patterns and naevus subtypes.
  • Lesion images were evaluated and checked for the presence of specific dermoscopic criteria, classified, and compared with a database of 350 acquired naevi.
  • RESULTS: Specific and unspecific dermoscopic features were identifiable in images acquired by means of all four instrument types.
  • The variegated naevus type was identified as a highly specific clinical/dermoscopic pattern.
  • Moreover, dermoscopy can be useful both for the classification of lesions already identified as congenital according to definite clinical and anamnestic data and for a possible correlation of naevus phenotype and dermoscopic patterns to the risk of developing a malignant melanoma in prospective studies.
  • [MeSH-major] Dermoscopy / instrumentation. Image Processing, Computer-Assisted. Nevus, Pigmented / pathology. Skin / pathology

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  • (PMID = 16792752.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] England
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14. Kiyohara T, Kouraba S, Takahashi H, Kawasaki T, Takeuchi A, Kumakiri M: Malignant melanoma with preserved hairs: a snap shot could suggest the development from an acquired melanocytic nevus. J Dermatol; 2010 Feb;37(2):167-70
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  • [Title] Malignant melanoma with preserved hairs: a snap shot could suggest the development from an acquired melanocytic nevus.
  • Partially, there were well-circumscribed, oval nests composed of nevus cells in the acanthotic epidermis and follicles.
  • Nevus cells were also seen in the dermal component, presenting a burnt-out appearance.
  • In this case, the small final size, the preserved hairs and the snap shot suggested a preceding, acquired melanocytic nevus.
  • Malignant melanoma could arise from acquired melanocytic nevus.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Melanoma / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • (PMID = 20175852.001).
  • [ISSN] 1346-8138
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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15. Hashimoto Y, Ito Y, Kato T, Motokawa T, Katagiri T, Itoh M: Expression profiles of melanogenesis-related genes and proteins in acquired melanocytic nevus. J Cutan Pathol; 2006 Mar;33(3):207-15
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  • [Title] Expression profiles of melanogenesis-related genes and proteins in acquired melanocytic nevus.
  • CONCLUSIONS: Our results suggest that all nevus cells that constitute AMN tissue originate from melanocytes.
  • Further, there may be differences in the transcription levels of melanogenesis-related genes as well as in their post-transcriptional regulation between nevus cells located in the basal epidermal to upper dermis layer and those in the lower dermis layer.
  • [MeSH-major] Gene Expression Regulation, Neoplastic. Genes, Neoplasm. Neoplasm Proteins / genetics. Nevus, Pigmented / genetics. Skin Neoplasms / genetics

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  • (PMID = 16466507.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MITF protein, human; 0 / Membrane Glycoproteins; 0 / Microphthalmia-Associated Transcription Factor; 0 / Neoplasm Proteins; 0 / PMEL protein, human; 0 / Proteins; 0 / RNA, Messenger; 0 / gp100 Melanoma Antigen; EC 1.- / Oxidoreductases; EC 1.14.18.- / TYRP1 protein, human; EC 5.3.- / Intramolecular Oxidoreductases; EC 5.3.3.12 / dopachrome isomerase
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16. Fernandez-Flores A: Plasma cell infiltrate in common acquired melanocytic nevus. Acta Dermatovenerol Croat; 2008;16(3):158-63
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  • [Title] Plasma cell infiltrate in common acquired melanocytic nevus.
  • The presence of plasma cells in melanocytic lesions has been considered in literature as a sign of concern, when evaluated in the appropriate context.
  • Plasma cells have been evaluated in halo nevus, but they are not frequently reported in non-halo common acquired nevus.
  • No relation between the amount of plasma cells and either the location of the nevus or the location of the inflammatory infiltrate could be established.
  • We conclude that the main point of this study is not to trust the presence of plasma cells as a solid criterion on its own, when evaluating a melanocytic lesion.
  • [MeSH-major] Nevus, Pigmented / pathology. Plasma Cells / pathology

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  • (PMID = 18812067.001).
  • [ISSN] 1330-027X
  • [Journal-full-title] Acta dermatovenerologica Croatica : ADC
  • [ISO-abbreviation] Acta Dermatovenerol Croat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Croatia
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17. Togawa Y, Nakamura Y, Kamada N, Kambe N, Takahashi Y, Matsue H: Melanoma in association with acquired melanocytic nevus in Japan: a review of cases in the literature. Int J Dermatol; 2010 Dec;49(12):1362-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanoma in association with acquired melanocytic nevus in Japan: a review of cases in the literature.
  • BACKGROUND: Malignant melanomas clinically and/or histologically associated with melanocytic nevi have been reported worldwide.
  • Approximately 20% of malignant melanomas in Caucasians, most of which are found on the trunk and proximal extremities, develop in association with pre-existing melanocytic nevi.
  • As ALMs are not usually accompanied by melanocytic nevi and there have been no reviews of the literature or statistical data regarding Japanese cases of melanomas with melanocytic nevi, dermatologists in Japan have few opportunities to see melanomas associated with pre-existing melanocytic nevi.
  • METHODS: Here we report a case of a superficial spreading melanoma that was formed on a melanocytic nevus on the trunk, and we review for the first time the case reports from the Japanese literature.
  • RESULTS AND CONCLUSIONS: With regard to the reported cases, melanomas associated with melanocytic nevi were mainly superficial spreading melanomas and nodular melanomas on the trunk or extremities; ALMs were rarely associated with nevi, indicating a trend similar to that observed in Caucasians.
  • These findings suggest that the low frequency of associations between melanomas and melanocytic nevi in Japan reflects racial differences in the frequencies of each type of melanoma.
  • [MeSH-major] Melanoma / complications. Melanoma / pathology. Nevus, Pigmented / complications. Skin Neoplasms / complications. Skin Neoplasms / pathology

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  • (PMID = 21155082.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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18. Pizzichetta MA, Massone C, Grandi G, Pelizzo G, Soyer HP: Morphologic changes of acquired melanocytic nevi with eccentric foci of hyperpigmentation ("Bolognia sign") assessed by dermoscopy. Arch Dermatol; 2006 Apr;142(4):479-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Morphologic changes of acquired melanocytic nevi with eccentric foci of hyperpigmentation ("Bolognia sign") assessed by dermoscopy.
  • BACKGROUND: Melanocytic nevi with eccentric foci of hyperpigmentation ("Bolognia sign") can be considered as a melanoma-simulating type of acquired melanocytic nevus.
  • We report on the morphologic changes of this type of melanocytic nevus over a 39-month period of dermoscopic follow-up.
  • After 39 months, a globular type of acquired melanocytic nevus was detectable, which clinically and dermoscopically appeared to be completely benign.
  • A nearly identical situation was observed in 5 other melanocytic nevi, underlining the involution of the pigmented foci in these nevi.
  • The histopathologic diagnoses of 2 lesions were consistent with a compound type of acquired melanocytic nevus with eccentric foci of hyperpigmentation.
  • CONCLUSIONS: Dermoscopy allows identification of a morphologic pathway of modifications, probably typical for this type of melanocytic nevus in children, and therefore enables avoidance of surgical excision with attendant hypertrophic scarring in children.
  • Conversely, in adults, when dermoscopic follow-up of melanocytic nevi reveals eccentric foci of hyperpigmentation, surgical excision of the lesion is indicated.
  • [MeSH-major] Hyperpigmentation / diagnosis. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis

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  • [CommentOn] Arch Dermatol. 2006 Apr;142(4):508 [16618873.001]
  • (PMID = 16618868.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Journal Article
  • [Publication-country] United States
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19. Prat Acín R, Galeano I: Giant occipital intradiploic epidermoid cyst associated with iatrogenic puncture. Acta Neurochir (Wien); 2008 Apr;150(4):413-4
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  • The origin of cranial epidermoid cysts (EC) remains controversial, and although generally considered to be congenital, acquired origin has been reported.
  • Three years previously, in the same location, she underwent resection of an intradermal melanocytic naevus of the skin under local anaesthesia with lidocaine infiltration of skin and periosteum.
  • Brain CT scan performed at the time of naevus surgery because of associated headache did not show a lesion of the cranial vault.
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Nevus, Pigmented / surgery. Reoperation. Scalp / surgery. Skin Neoplasms / surgery. Tomography, X-Ray Computed

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  • (PMID = 18301860.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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20. Tomasini C, Broganelli P, Pippione M: Targetoid hemosiderotic nevus. A trauma-induced simulator of malignant melanoma. Dermatology; 2005;210(3):200-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Targetoid hemosiderotic nevus. A trauma-induced simulator of malignant melanoma.
  • BACKGROUND: Simulators of malignant melanoma comprise a heterogenous group of melanocytic and nonmelanocytic lesions of the skin.
  • Among frequent clinical mimickers of melanoma are injured melanocytic nevi.
  • Any change in the clinical appearance of a pre-existing nevus should alert the clinician to exclude the possibility of malignant transformation in order to early identify a lesion at a stage when complete cure can still be achieved.
  • OBJECTIVE: The purpose of this study was to present the clinical, dermoscopic and histopathologic findings of a series of acquired melanocytic nevi which abruptly developed a pigmented peripheral halo, presumably following minor trauma.
  • METHODS: A series of 6 cases of acquired melanocytic nevi which suddenly developed a targetoid halo were included in the study.
  • The sudden development of an asymptomatic, targetoid halo on a long-lasting, acquired exophytic nevus was the main presentation.
  • Whereas the central nevus persisted, the ecchymotic halo ultimately disappeared.
  • Histopathologic examination disclosed changes of the traumatized nevus in the central part, whereas the ring showed hemorrhage and hemosiderin deposits.
  • CONCLUSIONS: Targetoid hemosiderotic nevus is a distinctive clinicopathologic variant of traumatized acquired melanocytic nevus which should be included in the list of clinical simulators of melanoma.
  • [MeSH-major] Nevus, Pigmented / diagnosis. Skin / injuries. Skin Neoplasms / diagnosis

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  • (PMID = 15785047.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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21. Yus ES, del Cerro M, Simón RS, Herrera M, Rueda M: Unna's and Miescher's nevi: two different types of intradermal nevus: hypothesis concerning their histogenesis. Am J Dermatopathol; 2007 Apr;29(2):141-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unna's and Miescher's nevi: two different types of intradermal nevus: hypothesis concerning their histogenesis.
  • In 1991, we tentatively introduced the classification of Ackerman and Magana-García for acquired melanocytic nevi in our laboratory.
  • We soon realized that every acquired intradermal melanocytic nevus might be easily classified into either Unna's or Miescher's patterns and that this classification had both clinical implications and significant histological differences.
  • The decisive discriminative feature between Unna's and Miescher's nevi is that Unna's nevus is an almost purely adventitial lesion confined to expanded papillary dermis and, many times, to the perifollicular dermis too.
  • In Miescher's nevus melanocytes diffusely infiltrate both adventitial and reticular dermis in a wedge-shaped pattern.
  • With these concepts in mind, every acquired intradermal melanocytic nevus can be easily classified as either Unna's or Miescher's.
  • We studied 751 acquired melanocytic nevi; 458 (61%) of them were intradermal; of these, 234 were Unna's nevi and 224 were Miescher's nevi.
  • Only on the scalp was there no clear predominance of one type of intradermal nevus.
  • Unna's nevi had more: junctional nests above the intradermal component (40% versus 20%), a radial pattern of intradermal nests (38% versus 0%), vascular-like clefts lined by nevus cells (48% versus 4%), and in depth maturation (94% versus 0%).
  • Miescher's nevi had more: pilosebaceous follicles within the nevus (100% versus 51%), subnevis folliculitis (12% versus 1%), large isolated melanocytes along the basal epidermal layer (47% versus 11%), multinucleated nevocytes (89% versus 44%), and adipocytes within the nevus (53% versus 11%).
  • In conclusion, Unna's and Miescher's nevi are 2 subsets of acquired melanocytic nevus with clinical implications and significant histological differences.
  • [MeSH-major] Nevus, Intradermal / pathology. Nevus, Pigmented / pathology. Skin / pathology. Skin Neoplasms / pathology

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  • (PMID = 17414435.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Ishihara Y, Saida T, Miyazaki A, Koga H, Taniguchi A, Tsuchida T, Toyama M, Ohara K: Early acral melanoma in situ: correlation between the parallel ridge pattern on dermoscopy and microscopic features. Am J Dermatopathol; 2006 Feb;28(1):21-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Early melanomas of this anatomic site are often misdiagnosed as melanocytic nevi, which are not uncommon on acral skin.
  • In fact, clinical and/or histopathological features of melanocytic nevi occasionally mimic those of early acral melanoma and vice versa, and thus differentiation of early acral melanoma from melanocytic nevus is sometimes very difficult for clinicians as well as for histopathologists.
  • In the present study, we reviewed 22 acral melanocytic lesions that showed the parallel ridge pattern on dermoscopy but had very subtle clinical and/or histopathological presentations.
  • We diagnosed 20 of them as early melanoma in situ by careful histopathological examination, which revealed histopathological features very similar to those seen in macular portions of overt acral melanoma, but fundamentally different from features found in melanocytic nevi on acral skin.
  • The two remaining lesions were diagnosed as possible cases of acquired melanocytic nevus because of the formation of well-demarcated nests of melanocytes in the epidermal rete ridges.

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  • (PMID = 16456320.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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23. Requena C, Requena L, Kutzner H, Sánchez Yus E: Spitz nevus: a clinicopathological study of 349 cases. Am J Dermatopathol; 2009 Apr;31(2):107-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spitz nevus: a clinicopathological study of 349 cases.
  • Spitz nevus is an infrequent, usually acquired melanocytic nevus composed of epithelioid and/or spindle melanocytes that can occasionally be confused with melanoma.
  • Currently, there are no immunohistochemical markers or molecular biology techniques that can be used to make an entirely safe diagnosis of Spitz nevus or melanoma in problematic cases.
  • A retrospective study has been carried out that included all the cases diagnosed as Spitz nevus from our files.
  • Spitz nevus was most commonly located on the lower extremities, followed by the trunk in both children and adults.
  • [MeSH-major] Nevus, Epithelioid and Spindle Cell / pathology. Skin / pathology. Skin Neoplasms / pathology

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  • [CommentIn] Am J Dermatopathol. 2010 Jun;32(4):410-4 [20145536.001]
  • (PMID = 19318795.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Bowling J: Fibrillar pattern of an acquired plantar acral melanocytic naevus: correspondence between epiluminescence light microscopy and transverse section histology. Clin Exp Dermatol; 2007 Jan;32(1):103
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fibrillar pattern of an acquired plantar acral melanocytic naevus: correspondence between epiluminescence light microscopy and transverse section histology.
  • [MeSH-major] Foot Diseases / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • [CommentOn] Clin Exp Dermatol. 2006 May;31(3):449-51 [16681598.001]
  • (PMID = 16939585.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] England
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25. Tanioka M, Kore-Eda S, Utani A, Miyachi Y, Tanaka M: Agminated acquired melanocytic nevus on the sole: clinical, dermoscopic and histopathological correlation. Eur J Dermatol; 2007 Mar-Apr;17(2):174-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Agminated acquired melanocytic nevus on the sole: clinical, dermoscopic and histopathological correlation.
  • [MeSH-major] Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 17337414.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] France
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