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1. Mahrous AK, Kalepu R: Positive findings on MRI in patients with asymmetrical SNHL. Eur Arch Otorhinolaryngol; 2008 Dec;265(12):1471-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The pickup rate was 1% for CPA lesion which was vestibular schwannoma.

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  • (PMID = 18478244.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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2. McClelland S 3rd, Gerbi BJ, Higgins PD, Orner JB, Hall WA: Safety and efficacy of fractionated stereotactic radiotherapy for acoustic neuromas. J Neurooncol; 2008 Jan;86(2):191-4
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  • [Title] Safety and efficacy of fractionated stereotactic radiotherapy for acoustic neuromas.
  • BACKGROUND: The treatment of acoustic neuromas (AN) has historically involved surgical excision or stereotactic radiosurgery, with a relatively limited number of reports available describing the use of fractionated stereotactic radiotherapy (FSRT).
  • Median tumor size (maximum diameter) was 2.1 cm (range, 1.1-3.4 cm).
  • RESULTS: Following FSRT, local tumor control was achieved in every patient, with the treatment well-tolerated by all patients.
  • No patient experienced acute complications or facial nerve weakness.
  • Two patients experienced permanent trigeminal nerve morbidity manifesting as facial numbness.
  • CONCLUSION: In our series of 20 patients with AN, all had local tumor control following FSRT, with minimal morbidity.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / methods. Stereotaxic Techniques
  • [MeSH-minor] Adult. Aged. Dose Fractionation. Female. Follow-Up Studies. Hearing Loss / etiology. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Radiography. Retrospective Studies. Treatment Outcome. Trigeminal Nerve / surgery

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  • (PMID = 17622486.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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3. Rajaraman P, Schwartz BS, Rothman N, Yeager M, Fine HA, Shapiro WR, Selker RG, Black PM, Inskip PD: Delta-aminolevulinic acid dehydratase polymorphism and risk of brain tumors in adults. Environ Health Perspect; 2005 Sep;113(9):1209-11
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  • [Title] Delta-aminolevulinic acid dehydratase polymorphism and risk of brain tumors in adults.
  • The enzyme delta-aminolevulinic acid dehydratase (ALAD), which catalyzes the second step of heme synthesis, can be inhibited by several chemicals, including lead, a potential risk factor for brain tumors, particularly meningioma.
  • In this study we examined whether the ALAD G177C polymorphism in the gene coding for ALAD is associated with risk of intracranial tumors of the brain and nervous system.
  • We use data from a case-control study with 782 incident brain tumor cases and 799 controls frequency matched on hospital, age, sex, race/ethnicity, and residential proximity to the hospital.
  • ALAD genotype was determined for 94% of these samples (355 glioma, 151 meningioma, 67 acoustic neuroma, and 505 controls).
  • No increased risk associated with the ALAD2 variant was observed for glioma or acoustic neuroma.
  • [MeSH-major] Brain Neoplasms / genetics. Genetic Predisposition to Disease. Meningioma / genetics. Porphobilinogen Synthase / genetics

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  • (PMID = 16140629.001).
  • [ISSN] 0091-6765
  • [Journal-full-title] Environmental health perspectives
  • [ISO-abbreviation] Environ. Health Perspect.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 4.2.1.24 / Porphobilinogen Synthase
  • [Other-IDs] NLM/ PMC1280403
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4. Schwarz C, Dang Burgener NP, Dosso AA: [OCT Visante observation of the progression of a perforated neurotrophic cornea ulcer treated with amniotic membrane grafts]. J Fr Ophtalmol; 2008 Apr;31(4):419-21
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  • [Transliterated title] Observation à l'OCT Visante de l'évolution d'un ulcère cornéen neurotrophique perforant traité par greffes de membranes amniotiques.
  • METHODS: A 71-year-old patient with facial nerve paresis secondary to vestibular schwannoma surgery presented with a neurotrophic perforated corneal ulcer.
  • [MeSH-minor] Aged. Disease Progression. Humans. Male

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  • (PMID = 18563043.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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5. Godefroy WP, van der Mey AG, de Bruine FT, Hoekstra ER, Malessy MJ: Surgery for large vestibular schwannoma: residual tumor and outcome. Otol Neurotol; 2009 Aug;30(5):629-34
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  • [Title] Surgery for large vestibular schwannoma: residual tumor and outcome.
  • OBJECTIVE: To evaluate clinical outcome with regard to the amount of residual tumor after surgery for large vestibular schwannoma.
  • PATIENTS: Between January 2000 and December 2005, 51 large vestibular schwannoma tumors with extrameatal diameter of 2.6 cm or greater (mean, 32 mm; median, 30 mm; range, 26-50 mm) were operated using the translabyrinthine approach.
  • The amount of residual tumor was measured, and the shape and localization was scored on gadolinium-enhanced magnetic resonance imaging (MRI).
  • Potential growth of residual tumor was documented with frequent MRI follow-up.
  • Postoperative facial nerve function was classified according to the House-Brackmann classification.
  • Magnetic resonance imaging showed residual tumor in 46% of patients (mean, 16.7 mm; SD, +/-8, range, 5-36 mm).
  • Postoperative facial nerve function was House-Brackmann Grades I to II in 78% of the patients.
  • Postoperative MRI showed either no residual tumor or residue that should actually have been classified as a subtotal resection.
  • CONCLUSION: Tumor control with good facial nerve function could be obtained in most patients.
  • Intraoperative assessment did not correlate with the amount of residual tumor on postoperative MRI.
  • [MeSH-major] Ear Neoplasms / surgery. Neuroma, Acoustic / surgery. Otologic Surgical Procedures
  • [MeSH-minor] Adult. Aged. Facial Nerve / pathology. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Postoperative Complications / epidemiology. Treatment Outcome. Young Adult

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  • (PMID = 19471168.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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6. Fortnum H, O'Neill C, Taylor R, Lenthall R, Nikolopoulos T, Lightfoot G, O'Donoghue G, Mason S, Baguley D, Jones H, Mulvaney C: The role of magnetic resonance imaging in the identification of suspected acoustic neuroma: a systematic review of clinical and cost effectiveness and natural history. Health Technol Assess; 2009 Mar;13(18):iii-iv, ix-xi, 1-154
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  • [Title] The role of magnetic resonance imaging in the identification of suspected acoustic neuroma: a systematic review of clinical and cost effectiveness and natural history.
  • OBJECTIVE(S): To evaluate the clinical effectiveness and cost-effectiveness of a range of diagnostic strategies for investigating patients with unilateral hearing loss and/or tinnitus, with a view to confirming or eliminating a diagnosis of acoustic neuroma, and to describe the natural history of acoustic neuroma.
  • ABR has high sensitivity compared with MR imaging for acoustic neuromas greater than 1 cm in size but not for smaller neuromas.
  • Non-contrast-enhanced MR imaging was found to be a more cost-effective test for acoustic neuroma than GdT1W MR imaging.
  • The incidence of acoustic neuroma has increased over the last 30 years, with the median age at diagnosis remaining at 55 years.
  • The pattern and rate of growth of acoustic neuroma are highly variable and currently unpredictable.
  • Given the recent improvement in resolution and reduction in cost of MR imaging, ABR can no longer be considered appropriate as the primary test used to screen for acoustic neuroma.
  • Based on a cost-effectiveness model developed to reflect UK practice it was concluded that a diagnostic algorithm that deploys non-contrast MR imaging as an initial imaging screen in the investigation of acoustic neuroma is less costly than and likely to be as effective as available contrast MR imaging.
  • [MeSH-major] Neuroma, Acoustic / diagnosis. Neuroma, Acoustic / economics
  • [MeSH-minor] Age Distribution. Cost-Benefit Analysis. Evoked Potentials, Auditory, Brain Stem. Hearing Tests. Humans. Incidence. Magnetic Resonance Imaging. Prevalence. Reproducibility of Results. Technology Assessment, Biomedical

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  • (PMID = 19358774.001).
  • [ISSN] 2046-4924
  • [Journal-full-title] Health technology assessment (Winchester, England)
  • [ISO-abbreviation] Health Technol Assess
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 244
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7. Abram S, Rosenblatt P, Holcomb S: Stereotactic radiation techniques in the treatment of acoustic schwannomas. Otolaryngol Clin North Am; 2007 Jun;40(3):571-88, ix
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  • [Title] Stereotactic radiation techniques in the treatment of acoustic schwannomas.
  • The goals of the treatment of acoustic schwannomas are prohibiting tumor growth and alleviation of symptoms caused by damage to local structures.
  • These symptoms-tinnitus, ataxia, and hearing loss--secondary to eighth nerve dysfunction, as well as symptoms arising from damage to adjacent structures such as the facial nerve, trigeminal nerve, or pons, can be caused by tumor growth or treatment.
  • Determination of optimal therapy must also take into account an understanding of the natural history of the disease, because acoustic schwannomas are slow-growing benign tumors that when left untreated, usually enlarge over time and cause problems.
  • [MeSH-major] Ear Neoplasms / pathology. Ear Neoplasms / radiotherapy. Neuroma, Acoustic / pathology. Neuroma, Acoustic / radiotherapy. Radiosurgery / instrumentation. Stereotaxic Techniques
  • [MeSH-minor] Algorithms. Dose Fractionation. Follow-Up Studies. Humans. Hydrocephalus / epidemiology. Magnetic Resonance Imaging. Neoplasm Invasiveness. Neurofibromatosis 2 / epidemiology. Tinnitus / epidemiology. Vertigo / epidemiology

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  • (PMID = 17544696.001).
  • [ISSN] 0030-6665
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 31
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8. Demetriades AK, Saunders N, Rose P, Fisher C, Rowe J, Tranter R, Hardwidge C: Malignant transformation of acoustic neuroma/vestibular schwannoma 10 years after gamma knife stereotactic radiosurgery. Skull Base; 2010 Sep;20(5):381-7
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  • [Title] Malignant transformation of acoustic neuroma/vestibular schwannoma 10 years after gamma knife stereotactic radiosurgery.
  • Only a handful of cases of de-novo malignancies of the vestibulocochlear nerve have been reported.
  • Even rarer is the malignant transformation of a previously histologically diagnosed benign vestibular schwannoma.
  • We present the case of a young adult who had combined operative/Gamma knife treatment for a benign vestibular schwannoma, followed by further surgery 2 years later.
  • He represented 10 years after original diagnosis with facial numbness and ataxia, MRI showing gross tumor recurrence.
  • After radical resection, histology showed malignant transformation to a malignant peripheral nerve sheath tumor.
  • Histology confirmed further de-differentiation to an anaplastic sarcoma.
  • While awaiting radiotherapy the tumor recurred again, the patient succumbing.
  • In the literature there are 13 other cases of malignant vestibular schwannomata.
  • The tumor biology of vestibular schwannomata as well as the radiobiology in the context of malignant transformation is discussed.

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  • (PMID = 21359005.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3023338
  • [Keywords] NOTNLM ; Gamma knife radiosurgery / Vestibular schwannoma / acoustic neuroma / anaplastic sarcoma / malignant peripheral nerve sheath tumor (MPNST) / malignant transformation / radiotherapy
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9. Sakai T, Vallejo MC, Shannon KT: A parturient with neurofibromatosis type 2: anesthetic and obstetric considerations for delivery. Int J Obstet Anesth; 2005 Oct;14(4):332-5
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  • Neurofibromatosis type 2 is an extremely rare form of neurofibromatosis characterized by central nervous system involvement with bilateral vestibular schwannomas and spinal tumors.
  • Anesthetic management of a parturient with neurofibromatosis type 2 has not been fully reported, and the condition is challenging to obstetric anesthesiologists due to the presence of intracranial and intraspinal canal neurofibromas.


10. Springborg JB, Poulsgaard L, Thomsen J: Nonvestibular schwannoma tumors in the cerebellopontine angle: a structured approach and management guidelines. Skull Base; 2008 Jul;18(4):217-27
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  • [Title] Nonvestibular schwannoma tumors in the cerebellopontine angle: a structured approach and management guidelines.
  • The most common cerebellopontine angle (CPA) tumor is a vestibular schwannoma, but one in five CPA tumors are not vestibular schwannomas.
  • These tumors may require different management strategies.
  • Compared with vestibular schwannomas, symptoms and signs from cranial nerve VIII are less frequent: other cranial nerve and cerebellar symptoms and signs predominate in patients with these less common CPA tumors.
  • This review provides a structured approach to the diagnosis of nonvestibular schwannoma CPA lesions and also management guidelines.

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  • (PMID = 19119337.001).
  • [ISSN] 1531-5010
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2467479
  • [Keywords] NOTNLM ; Cerebellopontine angle / epidermoids / management guidelines / meningiomas / tumors
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11. Saavedra E, Singh AD, Sears JE, Ratliff NB: Plexiform pigmented schwannoma of the uvea. Surv Ophthalmol; 2006 Mar-Apr;51(2):162-8
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  • [Title] Plexiform pigmented schwannoma of the uvea.
  • Schwannoma is a slow growing solitary tumor that preferentially involves spinal nerve roots, and sympathetic, cervical, and vagus nerves.
  • There are several clinico-pathologic variants of schwannoma, including schwannoma with a degenerative change (ancient schwannoma), cellular schwannoma, plexiform schwannoma, epithelioid schwannoma, and melanotic schwannoma.
  • About 10% of cases of schwannomas are associated with multi-system disorders such as neurofibromatosis, schwannomatosis, multiple meningiomas, and Carney complex.
  • Schwannoma rarely present as an intraocular tumor and is often misdiagnosed as malignant melanoma.
  • In this article, we review the clinical and histopathological findings of a sporadic plexiform pigmented schwannoma involving the iris, ciliary body, and the choroid.
  • [MeSH-major] Neurilemmoma / pathology. Uveal Neoplasms / pathology
  • [MeSH-minor] Child. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Iris / pathology. Iris / ultrasonography. Microscopy, Acoustic

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  • (PMID = 16500216.001).
  • [ISSN] 0039-6257
  • [Journal-full-title] Survey of ophthalmology
  • [ISO-abbreviation] Surv Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Karampelas I, Alberico RA, Plunkett RJ, Fenstermaker RA: Intratumoral hemorrhage after remote subtotal microsurgical resection and gamma knife radiosurgery for vestibular schwannoma. Acta Neurochir (Wien); 2007 Mar;149(3):313-6; discussion 316-7
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  • [Title] Intratumoral hemorrhage after remote subtotal microsurgical resection and gamma knife radiosurgery for vestibular schwannoma.
  • Our report describes the occurrence of intratumoral hemorrhage in a vestibular schwannoma, which was treated with microsurgical resection thirteen years and gamma knife surgery (GKS) more than two years prior to the event.
  • Although rare, it is apparent that bleeding into a vestibular schwannoma remains a possibility, even after the tumor has responded favorably to GKS.
  • Long-term followup of patients with vestibular schwannoma who have been treated with GKS is advisable to assess treatment response and to detect adverse events (e.g. hemorrhage) suspected on clinical grounds.
  • [MeSH-major] Cerebral Hemorrhage / diagnosis. Microsurgery. Neuroma, Acoustic / surgery. Postoperative Hemorrhage / diagnosis. Radiosurgery
  • [MeSH-minor] Cerebellopontine Angle / pathology. Follow-Up Studies. Hemosiderin / metabolism. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm, Residual / diagnosis

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  • (PMID = 17273886.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 9011-92-1 / Hemosiderin
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13. Kiratli H, Yildiz S, Soylemezoğlu F: Neurofibromatosis type 2: optic nerve sheath meningioma in one orbit, intramuscular schwannoma in the other. Orbit; 2008;27(6):451-4
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  • [Title] Neurofibromatosis type 2: optic nerve sheath meningioma in one orbit, intramuscular schwannoma in the other.
  • A highly unusual patient with neurofibromatosis type 2 (NF2) presenting with simultaneous bilateral orbital tumors is described.
  • Magnetic resonance imaging studies showed bilateral cerebellopontine angle tumors, a tumor surrounding the right intraorbital optic nerve, and a large left lateral orbital mass mixed with the lateral rectus muscle.
  • The histopathological diagnoses following incisional biopsies were right optic nerve sheath meningioma and left intramuscular schwannoma.
  • The left-sided orbital schwannoma and the right-sided vestibular schwannoma were treated with fractionated stereotactic radiotherapy.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningioma / pathology. Muscle Neoplasms / pathology. Neoplasms, Second Primary / pathology. Neurilemmoma / pathology. Neurofibromatosis 2 / pathology. Orbital Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Child. Female. Functional Laterality. Hamartoma / pathology. Humans. Magnetic Resonance Imaging. Neoplasm Proteins / analysis. Neuroma, Acoustic / chemistry. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Oculomotor Muscles / pathology. Radiosurgery. Radiotherapy, Conformal. Retinal Diseases / pathology


14. Chen S, Xu Y, Ou Y, Zheng Y, Deng Y, Chen B: [Endoscope-assisted surgical resection of acoustic neuroma]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 Aug;22(16):729-31
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  • [Title] [Endoscope-assisted surgical resection of acoustic neuroma].
  • OBJECTIVE: To explore the therapeutic efficacy and complications of endoscope-assisted surgical resection of acoustic neuroma.
  • METHOD: Assisted by hard-tube ear endoscope, 11 patients with acoustic neuroma were operated via labyrinthine approach and retrosigmoid approach.
  • CONCLUSION: The application of ear endoscope in acoustic neuroma surgery can improve the total removal rate of tumors and the salvage rate of vessels and nerves.
  • [MeSH-major] Endoscopy. Neuroma, Acoustic / surgery

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  • (PMID = 18975773.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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15. Izycka-Swieszewska E, Szurowska E, Kloc W, Rzepko R, Dubaniewicz-Wybieralska M, Skorek A, Drozyńska E, Stempniewicz M: Cerebellopontine angle tumours: radiologic-pathologic correlation and diagnostic difficulties. Folia Neuropathol; 2006;44(4):274-81
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  • Histopathologically the material consisted of 77 schwannomas and 42 non-acoustic tumours.
  • In our series non-acoustic tumours made up 37% of CPA lesions.
  • Sharp tumour-pyramis angle and intracanalicular fraction are not exclusive features of schwannomas.

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  • (PMID = 17183454.001).
  • [ISSN] 1641-4640
  • [Journal-full-title] Folia neuropathologica
  • [ISO-abbreviation] Folia Neuropathol
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Poland
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16. Arriaga MA, Chen DA, Burke EL: Hydroxyapatite cement cranioplasty in translabyrinthine acoustic neuroma surgery-update. Otol Neurotol; 2007 Jun;28(4):538-40
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  • [Title] Hydroxyapatite cement cranioplasty in translabyrinthine acoustic neuroma surgery-update.
  • OBJECTIVE: To update the outcome of hydroxyapatite cement cranioplasty in translabyrinthine acoustic neuroma (TLAN) surgery.
  • [MeSH-major] Ear Neoplasms / surgery. Ear, Inner / surgery. Neuroma, Acoustic / surgery. Otologic Surgical Procedures

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  • (PMID = 17414174.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Bone Cements; 91D9GV0Z28 / Durapatite
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17. Khrais T, Sanna M: Hearing preservation surgery in vestibular schwannoma. J Laryngol Otol; 2006 May;120(5):366-70
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  • [Title] Hearing preservation surgery in vestibular schwannoma.
  • OBJECTIVES: To study the effect of pre-operative hearing level and tumour size on the hearing outcome of hearing preservation surgery for vestibular schwannoma.
  • RESULTS: A total of 1993 patients in 16 publications addressing the topic of hearing preservation surgery in vestibular schwannoma were analysed.
  • [MeSH-major] Hearing. Neuroma, Acoustic / surgery

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  • (PMID = 16556349.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 27
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18. Hadfield KD, Smith MJ, Urquhart JE, Wallace AJ, Bowers NL, King AT, Rutherford SA, Trump D, Newman WG, Evans DG: Rates of loss of heterozygosity and mitotic recombination in NF2 schwannomas, sporadic vestibular schwannomas and schwannomatosis schwannomas. Oncogene; 2010 Nov 25;29(47):6216-21
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  • [Title] Rates of loss of heterozygosity and mitotic recombination in NF2 schwannomas, sporadic vestibular schwannomas and schwannomatosis schwannomas.
  • Biallelic inactivation of the NF2 gene occurs in the majority of schwannomas.
  • We have performed DNA sequence and dosage analysis of the NF2 gene in a panel of 239 schwannoma tumours: 97 neurofibromatosis type 2 (NF2)-related schwannomas, 104 sporadic vestibular schwannomas (VS) and 38 schwannomatosis-related schwannomas.
  • LOH was present in 28 out of 34 (82%) schwannomatosis-related schwannomas.
  • This study shows that MR is a mechanism of LOH in NF2 and SMARCB1-negative schwannomatosis-related schwannomas, occurring less frequently in sporadic vs. We found no evidence of MR in SMARCB1-positive schwannomatosis, suggesting that susceptibility to MR varies according to the disease context.
  • [MeSH-minor] Adolescent. Adult. Child. Chromosome Breakpoints. Gene Dosage / genetics. Genes, Neurofibromatosis 2. Homozygote. Humans. Neurilemmoma / genetics. Neurofibromatoses / genetics. Polymorphism, Single Nucleotide / genetics. Skin Neoplasms / genetics. Young Adult

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  • (PMID = 20729918.001).
  • [ISSN] 1476-5594
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] Schwannomatosis
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19. Coca A, Gómez JR, Llorente JL, Rodrigo JP, Núñez F, Sevilla MA, Suárez C: [Complications and sequelae in acoustic neuroma surgery]. Acta Otorrinolaringol Esp; 2007 Dec;58(10):470-5
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  • [Title] [Complications and sequelae in acoustic neuroma surgery].
  • [Transliterated title] Complicaciones y secuelas en la cirugía de los neurinomas del acústico.
  • OBJECTIVE: To evaluate the complications and sequelae of acoustic neuroma surgery, according to tumour size.
  • PATIENTS AND METHOD: A retrospective analysis of 120 patients who underwent microsurgical resection of vestibular schwannomas between November 1994 and September 2006 was undertaken.
  • The facial nerve was anatomically and functionally preserved in 103 cases on long-term follow-up (85.4 %).
  • The cochlear nerve was functionally preserved (Gardner-Robertson class 1 and 2) in 54.4 % of the small tumours with useful preoperative hearing.
  • CONCLUSIONS: Despite the progress in the surgical treatment of acoustic neuromas, a considerable rate of complications and sequelae still remains.
  • [MeSH-major] Neuroma, Acoustic / epidemiology. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / statistics & numerical data. Postoperative Complications / epidemiology


20. Marshall AH, Owen VM, Nikolopoulos TP, O'Donoghue GM: Acoustic schwannomas: awareness of radiologic error will reduce unnecessary treatment. Otol Neurotol; 2005 May;26(3):512-5
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  • [Title] Acoustic schwannomas: awareness of radiologic error will reduce unnecessary treatment.
  • OBJECTIVE: To measure the intra- and interobserver error in size estimation of acoustic schwannomas from magnetic resonance imaging (MRI) scans by experienced radiologists to determine whether small amounts of tumor growth that may affect management (2 mm) could be reliably measured in clinical practice.
  • DESIGN: Duplicated, blinded size estimation of acoustic neuromas (according to American Academy of Otolaryngology-Head and Neck Surgery guidelines, 1995) from MRI scans of patients with acoustic neuromas.
  • PARTICIPANTS: Four radiologists (including 2 dedicated neuroradiologists) measuring positive MRI scans of 26 patients with an acoustic neuroma.
  • MAIN OUTCOME MEASURE: Intraradiologist and inter-radiologist repeatability coefficients in millimeters for the maximal tumor diameter in the anteroposterior (AP) axis, medial-longitudinal (ML) axis, and the square-root of the product of these two measurements.
  • CONCLUSION: The study indicates that, in routine clinical practice, differences in tumor size of the order of 2 mm cannot be reliably measured, even by the same radiologist.
  • Thus, reported growth of acoustic tumors should be interpreted with caution, especially if this is the criterion for recommending treatment.
  • [MeSH-major] Magnetic Resonance Imaging. Neuroma, Acoustic / diagnosis

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  • (PMID = 15891658.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Chung SJ, Im JH, Lee JH, Cho AH, Kwon M, Lee MC: Isolated tongue tremor after gamma knife radiosurgery for acoustic schwannoma. Mov Disord; 2005 Jan;20(1):108-11
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  • [Title] Isolated tongue tremor after gamma knife radiosurgery for acoustic schwannoma.
  • We describe a patient who had an isolated tongue tremor with an audible click after gamma knife radiosurgery for acoustic schwannoma.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / adverse effects. Tongue Diseases / etiology. Tremor / etiology

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  • [Copyright] (c) 2004 Movement Disorder Society.
  • (PMID = 15390040.001).
  • [ISSN] 0885-3185
  • [Journal-full-title] Movement disorders : official journal of the Movement Disorder Society
  • [ISO-abbreviation] Mov. Disord.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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22. Hori T, Okada Y, Maruyama T, Chernov M, Attia W: Endoscope-controlled removal of intrameatal vestibular schwannomas. Minim Invasive Neurosurg; 2006 Feb;49(1):25-9
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  • [Title] Endoscope-controlled removal of intrameatal vestibular schwannomas.
  • The use of endoscopes for surgery of the cerebellopontine angle tumors is steadily obtaining widespread acceptance.
  • The objective of the present study was a laboratory and clinical evaluation of the safety of the endoscope-controlled microneurosurgical removal of the intrameatal vestibular schwannomas through a retrosigmoid approach.
  • Use of the endoscope permitted removal of the neoplasm from the most lateral part of the internal auditory canal and identification of the nerve of tumor origin.
  • In total, 28 tumors underwent total removal, and anatomical preservation of the facial nerve was attained in 31 cases.
  • Damage of the facial nerve by the endoscope was met once.
  • In 8 out of 16 patients, who showed serviceable hearing before surgery, this was preserved after tumor removal.
  • In conclusion, endoscope-controlled removal of the intrameatal vestibular schwannomas seems to be a technically feasible, effective and safe procedure.
  • [MeSH-major] Microsurgery / instrumentation. Neoplasm Recurrence, Local / surgery. Neuroendoscopes. Neuroma, Acoustic / surgery
  • [MeSH-minor] Adult. Aged. Cadaver. Cerebellopontine Angle. Facial Nerve / physiopathology. Feasibility Studies. Female. Hearing / physiology. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 16547878.001).
  • [ISSN] 0946-7211
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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23. Slattery WH 3rd, Fisher LM, Hitselberger W, Friedman RA, Brackmann DE: Hearing preservation surgery for neurofibromatosis Type 2-related vestibular schwannoma in pediatric patients. J Neurosurg; 2007 Apr;106(4 Suppl):255-60
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  • [Title] Hearing preservation surgery for neurofibromatosis Type 2-related vestibular schwannoma in pediatric patients.
  • OBJECT: The authors reviewed the proportion of pediatric patients with neurofibromatosis Type 2 (NF2) in whom hearing was preserved after middle fossa resection of vestibular schwannoma (VS).
  • Speech discrimination scores (SDSs) and pre- and postfacial nerve grades were also recorded.
  • Facial nerve function was good (House-Brackmann Grades I or II) in 81% of the patients.
  • [MeSH-major] Facial Nerve / physiopathology. Hearing / physiology. Neurofibromatosis 2 / surgery. Neuroma, Acoustic / surgery


24. Stojicic MT, Slavik EE, Acimovic GT, Jovanovic MD, Stojmirovic DM, Vujotic LD: Simultaneous surgical treatment of ulcer terebrans with intracranial propagation and acoustic neurinoma on the same side: a case report. J Plast Reconstr Aesthet Surg; 2008 Nov;61(11):e9-11
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  • [Title] Simultaneous surgical treatment of ulcer terebrans with intracranial propagation and acoustic neurinoma on the same side: a case report.
  • This article presents a successful surgical treatment of the patient with aggressive basal cell carcinoma with intracranial propagation (ulcer terebrans) and simultaneous acoustic neurinoma on the same side.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Neoplasms, Multiple Primary / surgery. Neuroma, Acoustic / surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Brain / pathology. Female. Humans. Magnetic Resonance Imaging. Meninges / pathology. Middle Aged. Neoplasm Invasiveness. Reconstructive Surgical Procedures / methods. Scalp / pathology

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  • (PMID = 18718834.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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25. Varughese JK, Wentzel-Larsen T, Vassbotn F, Moen G, Lund-Johansen M: Analysis of vestibular schwannoma size in multiple dimensions: a comparative cohort study of different measurement techniques. Clin Otolaryngol; 2010 Apr;35(2):97-103
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  • [Title] Analysis of vestibular schwannoma size in multiple dimensions: a comparative cohort study of different measurement techniques.
  • OBJECTIVES: In this volumetric study of the vestibular schwannoma, we evaluated the accuracy and reliability of several approximation methods that are in use, and determined the minimum volume difference that needs to be measured for it to be attributable to an actual difference rather than a retest error.
  • [MeSH-major] Ear Neoplasms / pathology. Magnetic Resonance Imaging / methods. Neoplasm Invasiveness. Neuroma, Acoustic / pathology
  • [MeSH-minor] Adult. Aged. Cohort Studies. Female. Gadolinium. Humans. Incidence. Isotopes. Male. Middle Aged. Neoplasm Staging. Observer Variation. Radiosurgery / instrumentation. Reproducibility of Results. Research Design

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  • (PMID = 20500578.001).
  • [ISSN] 1749-4486
  • [Journal-full-title] Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • [ISO-abbreviation] Clin Otolaryngol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Isotopes; AU0V1LM3JT / Gadolinium
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26. Stangerup SE, Caye-Thomasen P, Tos M, Thomsen JC: [Incidence of vestibular schwannoma in Denmark]. Ugeskr Laeger; 2008 Oct 13;170(42):3335-8
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  • [Title] [Incidence of vestibular schwannoma in Denmark].
  • INTRODUCTION: During the last 30 years the number of diagnosed vestibular schwannomas (VS) has increased from 15 in 1976 to 116 in 2006.
  • CONCLUSION: With easier access to MRI, vestibular schwannomas are found earlier when they are still small.
  • [MeSH-major] Neuroma, Acoustic / epidemiology

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  • (PMID = 18940171.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Denmark
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27. Gimsing S: Vestibular schwannoma: when to look for it? J Laryngol Otol; 2010 Mar;124(3):258-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vestibular schwannoma: when to look for it?
  • OBJECTIVES:. (1) To compare audiometric parameters in patients with vestibular schwannoma and in those with asymmetric hearing loss from other causes; and (2) to assess proposed screening criteria by comparing published protocols.
  • METHODS: Audiometric data from 199 vestibular schwannoma patients and 225 non-tumour patients were compared.
  • RESULTS: Vestibular schwannoma and non-tumour patients with little or no hearing loss in the unaffected ear were inseparable; however, vestibular schwannoma patients with hearing loss in the unaffected ear had greater audiometric asymmetry, compared with non-tumour patients with the same pattern of hearing loss.
  • CONCLUSION: As regards vestibular schwannoma screening protocols, the best compromise between sensitivity and screening rate was offered by a criterion comprising either:.
  • [MeSH-major] Audiometry. Hearing Loss, Unilateral / diagnosis. Neuroma, Acoustic / diagnosis

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  • (PMID = 19922702.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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28. Brackmann DE, Green JD Jr: Translabyrinthine approach for acoustic tumor removal. 1992. Neurosurg Clin N Am; 2008 Apr;19(2):251-64, vi
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  • [Title] Translabyrinthine approach for acoustic tumor removal. 1992.
  • It is the preferred approach for removal of all tumors in patients with poor hearing and for large tumors when the likelihood of hearing preservation is slight.
  • This approach offers the advantages of minimum cerebellar retraction, identification of the facial nerve proximally and medially, and the ability to repair immediately the facial nerve if it is severed during acoustic tumor removal.
  • [MeSH-major] Neuroma, Acoustic / history. Neurosurgical Procedures / history. Otologic Surgical Procedures / history

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  • (PMID = 18534338.001).
  • [ISSN] 1558-1349
  • [Journal-full-title] Neurosurgery clinics of North America
  • [ISO-abbreviation] Neurosurg. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Biography; Classical Article; Historical Article; Journal Article
  • [Publication-country] United States
  • [Personal-name-as-subject] Brackmann DE; Green JD Jr
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29. Dagain A, Pouit B, Dutertre G, Dulou R: Role of cystoperitoneal shunt in the setup of cystic vestibular schwannomas drainage. Acta Neurochir (Wien); 2010 Aug;152(8):1441-2
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  • [Title] Role of cystoperitoneal shunt in the setup of cystic vestibular schwannomas drainage.
  • [MeSH-major] Central Nervous System Cysts / etiology. Central Nervous System Cysts / surgery. Cerebrospinal Fluid Shunts / methods. Neuroma, Acoustic / complications. Neuroma, Acoustic / surgery. Neurosurgical Procedures / methods

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  • [CommentOn] Acta Neurochir (Wien). 2010 Jan;152(1):177-80 [19693430.001]
  • (PMID = 20354735.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] Austria
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30. Gong S, Chen G, Zhong G, Yan K, Zhang E, Chen P, Lin N, Nie X: [Neurofibromatosis type 2]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2006 Aug;20(16):721-3
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  • The patient was diagnosed as NF2 according to the National Institutes of Health (NIH) criteria, and received operation on the left acoustic tumor.
  • The tumor was proved to be schwannomas by pathological test.
  • The hearing loss and the facial nerve paralysis (House-Brackmann II) had appeared after operation.
  • CONCLUSION: NF2 is an autosomal dominant, highly penetrant disease which is characterized by bilateral vestibular schwannomas.
  • Early diagnosis and management for tumor is very important for survival and hearing preservation.

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  • (PMID = 17058913.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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31. Darwish BS, Bird PA, Goodisson DW, Bonkowski JA, MacFarlane MR: Facial nerve function and hearing preservation after retrosigmoid excision of vestibular schwannoma: Christchurch Hospital experience with 97 patients. ANZ J Surg; 2005 Oct;75(10):893-6
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  • [Title] Facial nerve function and hearing preservation after retrosigmoid excision of vestibular schwannoma: Christchurch Hospital experience with 97 patients.
  • BACKGROUND: Between January 1988 and December 2002, 97 patients underwent surgery for excision of vestibular schwannoma via the retrosigmoid approach at Christchurch Hospital.
  • METHODS: A retrospective review was undertaken of the clinical notes with emphasis on facial nerve function and hearing preservation postoperatively.
  • RESULTS: Of patients with small and medium-sized tumours, 81% had good facial nerve function at 1 year (House-Brackmann grade 1 and grade 2), 16% had moderate function (grade 3 and grade 4) and 3% had poor function (grade 5).
  • CONCLUSIONS: Tumour size was an important predictor of the postoperative facial and cochlear nerve function.
  • [MeSH-major] Facial Nerve / physiology. Hearing / physiology. Neuroma, Acoustic / surgery
  • [MeSH-minor] Adolescent. Adult. Auditory Threshold. Female. Hearing Loss / etiology. Humans. Male. Neoplasm Recurrence, Local. Neurofibromatosis 2 / surgery. Postoperative Complications. Retrospective Studies. Time Factors. Tinnitus / etiology. Treatment Outcome. Vertigo / etiology

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  • (PMID = 16176235.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Australia
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32. Astner ST, Nieder C, Stock K, Gaa J, Grosu AL: Carcinomatous meningitis appearing as acoustic neuromas: two cases. Strahlenther Onkol; 2007 May;183(5):279-83
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  • [Title] Carcinomatous meningitis appearing as acoustic neuromas: two cases.
  • BACKGROUND: For acoustic neuromas, stereotactic radiotherapy (radiosurgery or stereotactic fractionated radiotherapy) has been established as an important alternative to microsurgery.
  • MRI scan shows a contrast-enhancing tumor within the inner auditory channel.
  • If medical history does not match with acoustic neuroma, further diagnostics are necessary to rule out infectious disease or carcinomatous meningitis.
  • CASE REPORT: Two patients with hearing loss, vertigo and the diagnosis of acoustic neuromas by MRI scan were referred for radiotherapy.
  • In both cases the symptoms progressed very rapidly, not typical of acoustic neuromas, and in both patients repeated liquor puncture finally revealed carcinomatous meningitis.
  • This is especially true for bilateral lesions suspicious for acoustic neuromas and rapid progression and persistence of clinical symptoms where carcinomatous meningitis has to be taken into account.
  • [MeSH-major] Esophageal Neoplasms / diagnosis. Meningeal Neoplasms / secondary. Neoplasms, Multiple Primary / diagnosis. Neuroma, Acoustic / diagnosis

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  • (PMID = 17497100.001).
  • [ISSN] 0179-7158
  • [Journal-full-title] Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
  • [ISO-abbreviation] Strahlenther Onkol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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33. Kondziolka D, Lunsford LD: Future perspectives in acoustic neuroma management. Prog Neurol Surg; 2008;21:247-54
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  • [Title] Future perspectives in acoustic neuroma management.
  • Management options for patients with vestibular schwannomas (acoustic neuromas) include observation, resection, stereotactic radiosurgery, or fractionated radiotherapy.
  • There has been an evolution in available technologies, and an evolution in both patient and physician approaches to the management of this tumor.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / trends

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  • (PMID = 18810226.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 65
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34. Muscat JE, Hinsvark M, Malkin M: Mobile telephones and rates of brain cancer. Neuroepidemiology; 2006;27(1):55-6
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  • [Title] Mobile telephones and rates of brain cancer.
  • The risk of most primary brain cancers including gliomas and acoustic neuromas is unrelated to the use of mobile telephones in several studies.
  • An increased risk caused by short-term mobile phone use was reported for neuroepithelial tumors, a rare histologic subgroup of brain cancers that are characterized by neuronal features.
  • [MeSH-major] Brain Neoplasms / epidemiology. Cell Phones / utilization. Ganglioglioma / epidemiology

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  • (PMID = 16825795.001).
  • [ISSN] 0251-5350
  • [Journal-full-title] Neuroepidemiology
  • [ISO-abbreviation] Neuroepidemiology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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35. Ahlbom A, Feychting M, Green A, Kheifets L, Savitz DA, Swerdlow AJ, ICNIRP (International Commission for Non-Ionizing Radiation Protection) Standing Committee on Epidemiology: Epidemiologic evidence on mobile phones and tumor risk: a review. Epidemiology; 2009 Sep;20(5):639-52
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  • [Title] Epidemiologic evidence on mobile phones and tumor risk: a review.
  • This review summarizes and interprets epidemiologic evidence bearing on a possible causal relation between radiofrequency field exposure from mobile phone use and tumor risk.
  • In the last few years, epidemiologic evidence on mobile phone use and the risk of brain and other tumors of the head in adults has grown in volume, geographic diversity of study settings, and the amount of data on longer-term users.
  • Overall the studies published to date do not demonstrate an increased risk within approximately 10 years of use for any tumor of the brain or any other head tumor.
  • Despite the methodologic shortcomings and the limited data on long latency and long-term use, the available data do not suggest a causal association between mobile phone use and fast-growing tumors such as malignant glioma in adults (at least for tumors with short induction periods).
  • For slow-growing tumors such as meningioma and acoustic neuroma, as well as for glioma among long-term users, the absence of association reported thus far is less conclusive because the observation period has been too short.
  • [MeSH-major] Brain Neoplasms / etiology. Cell Phones. Glioma / etiology. Neoplasms, Radiation-Induced / etiology. Risk Assessment
  • [MeSH-minor] Brain / radiation effects. Humans. Research Design

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  • [CommentIn] Epidemiology. 2009 Sep;20(5):653-5 [19620872.001]
  • (PMID = 19593153.001).
  • [ISSN] 1531-5487
  • [Journal-full-title] Epidemiology (Cambridge, Mass.)
  • [ISO-abbreviation] Epidemiology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 48
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36. Raptis HA, Dannenbaum E, Paquet N, Feldman AG: Vestibular system may provide equivalent motor actions regardless of the number of body segments involved in the task. J Neurophysiol; 2007 Jun;97(6):4069-78
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  • [Title] Vestibular system may provide equivalent motor actions regardless of the number of body segments involved in the task.
  • To test this hypothesis, we compared the ability of healthy subjects and patients with unilateral vestibular lesions (surgical acoustic neuroma resection 0.6 to 6.7 yr before the study) to maintain either the same hand position or the same trajectory of within arm reach movements while flexing the trunk, in the absence of vision.
  • Results suggest that vestibular influences evoked by the head motion during trunk flexion play a major role in maintaining the consistency of arm motor actions in external space despite changes in the number of body segments involved.
  • Our findings also suggest that despite long-term plasticity in the vestibular system and related neural structures, unilateral vestibular lesion may reduce the capacity of the nervous system to achieve motor equivalence.
  • [MeSH-minor] Adult. Analysis of Variance. Electromyography. Female. Functional Laterality. Humans. Male. Middle Aged. Task Performance and Analysis. Upper Extremity / innervation. Vestibular Diseases / physiopathology

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  • (PMID = 17428903.001).
  • [ISSN] 0022-3077
  • [Journal-full-title] Journal of neurophysiology
  • [ISO-abbreviation] J. Neurophysiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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37. Browne JD, Fisch U: Transotic approach to the cerebellopontine angle. 1992. Neurosurg Clin N Am; 2008 Apr;19(2):265-78, vi
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  • The transotic approach to the cerebellopontine angle has been developed at the University of Zurich for the removal of acoustic tumors in an effort to increase operative exposure and enhance facial nerve preservation and reconstruction.
  • Key steps involve the total removal of all pneumatic cell tracts with middle ear and eustachian tube obliteration, followed by complete otic capsule removal for tumor exposure.
  • [MeSH-major] Cerebellar Neoplasms / history. Cerebellopontine Angle. Neuroma, Acoustic / history. Neurosurgical Procedures / history. Otologic Surgical Procedures / history

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  • (PMID = 18534339.001).
  • [ISSN] 1558-1349
  • [Journal-full-title] Neurosurgery clinics of North America
  • [ISO-abbreviation] Neurosurg. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Biography; Classical Article; Historical Article; Journal Article
  • [Publication-country] United States
  • [Personal-name-as-subject] Browne JD; Fisch U
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38. Freeman SR, Ramsden RT, Saeed SR, Alzoubi FQ, Simo R, Rutherford SA, King AT: Revision surgery for residual or recurrent vestibular schwannoma. Otol Neurotol; 2007 Dec;28(8):1076-82
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  • [Title] Revision surgery for residual or recurrent vestibular schwannoma.
  • OBJECTIVE: Assess the requirement for and describe the complication rates of revision surgery for vestibular schwannoma.
  • PATIENTS: Patients undergoing surgery for vestibular schwannoma by the Manchester Neurotology Service between 1978 and 2004.
  • MAIN OUTCOME MEASURE(S): The presence of recurrent or residual tumor; necessity for further treatment; complications from revision surgery.
  • RESULTS: Primary surgery was undertaken on 1,037 tumors, with 866 total (19 recurred), 128 near-total, and 43 subtotal removals.
  • Further treatment was performed for 4 recurrent, 2 near-total, and 11 subtotal excised tumors.
  • Other complications of revision surgery included 3 patients with cerebrospinal fluid leaks, a postoperative hematoma requiring evacuation, 2 cerebrovascular accidents, and 2 patients with new cranial nerve deficits.
  • CONCLUSION: Most residual tumors after primary surgery are successfully managed with watch and rescan.
  • Tumor fragment size is the greatest determinant of revision treatment.
  • After revision surgery, tumor regrowth is much less predictable.
  • Revision surgery is usually considerably more difficult than primary surgery, with a higher complication rate, particularly with regard to the facial nerve.
  • Changing the approach for revision surgery may confer an advantage to facial nerve function.
  • [MeSH-major] Ear Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Neuroma, Acoustic / surgery. Otologic Surgical Procedures
  • [MeSH-minor] Adolescent. Adult. Aged. Databases, Factual. Facial Nerve / pathology. Facial Nerve / physiopathology. Female. Humans. Male. Middle Aged. Postoperative Complications / epidemiology. Reoperation / adverse effects. Sex Ratio

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  • (PMID = 18043433.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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39. Smouha EE, Yoo M, Mohr K, Davis RP: Conservative management of acoustic neuroma: a meta-analysis and proposed treatment algorithm. Laryngoscope; 2005 Mar;115(3):450-4
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  • [Title] Conservative management of acoustic neuroma: a meta-analysis and proposed treatment algorithm.
  • OBJECTIVES/HYPOTHESES: Conservative management is a viable treatment alternative for acoustic neuroma.
  • METHODS: Published studies on conservative management of acoustic neuroma were found using a key word search through PubMed in addition to the bibliographies of these selected studies.
  • A spreadsheet was made to tabulate the selection criteria for conservative management, duration and frequency of follow-up, patient demographics, initial tumor size and rate of growth, change in hearing status, and the need for definitive treatment.
  • The average initial tumor size was 11.8 mm (n = 900); 43% of 1,244 acoustic neuromas showed growth, whereas 57% showed either no growth or tumor regression.
  • CONCLUSIONS: Our meta-analysis supports the role of conservative management of acoustic neuromas in properly selected patients on the basis of a slow overall rate of growth and a substantial incidence of no growth.
  • An algorithm for acoustic neuroma management is proposed based on initial tumor size, patient age, and hearing status.
  • [MeSH-major] Algorithms. Neuroma, Acoustic / therapy

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  • [CommentIn] Laryngoscope. 2005 Sep;115(9):1704; author reply 1704 [16148723.001]
  • (PMID = 15744156.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] United States
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40. Shuto T, Inomori S, Matsunaga S, Fujino H: Microsurgery for vestibular schwannoma after gamma knife radiosurgery. Acta Neurochir (Wien); 2008 Mar;150(3):229-34; discussion 234
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  • [Title] Microsurgery for vestibular schwannoma after gamma knife radiosurgery.
  • BACKGROUND: We evaluated the clinical characteristics of microsurgery for vestibular schwannoma (VS) after failed gamma knife radiosurgery (GKS).
  • Adhesion to the brain stem was severe in 7 patients.
  • Identification of the facial nerve was easy in 5 operations and difficult in 7.
  • Dissection of the tumour from the facial nerve was difficult in most interventions because of severe adhesions or colour change.
  • Severe adhesions between the trigeminal nerve and the tumour was observed in 2 patients.
  • The function of the facial nerve deteriorated in 3 patients, was unchanged in 7, and improved in 2.
  • Dissection of the tumour from the facial nerve or brain stem is likely to be difficult.
  • We recommend subtotal resection without dissection of the facial nerve and tumour, because growth of the residual tumour was rare in our series.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Microsurgery / methods. Neuroma, Acoustic / surgery. Radiosurgery / methods. Vestibulocochlear Nerve Diseases / surgery
  • [MeSH-minor] Adult. Aged. Dissection / methods. Dissection / standards. Ear, Inner / anatomy & histology. Ear, Inner / pathology. Ear, Inner / surgery. Facial Nerve / pathology. Facial Nerve / physiopathology. Facial Nerve / surgery. Facial Nerve Injuries / etiology. Facial Nerve Injuries / physiopathology. Facial Nerve Injuries / prevention & control. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Neurosurgical Procedures / methods. Neurosurgical Procedures / standards. Neurosurgical Procedures / statistics & numerical data. Petrous Bone / anatomy & histology. Petrous Bone / pathology. Petrous Bone / surgery. Postoperative Complications / etiology. Postoperative Complications / physiopathology. Postoperative Complications / prevention & control. Retrospective Studies. Treatment Failure. Treatment Outcome. Trigeminal Nerve / pathology. Trigeminal Nerve / physiopathology. Trigeminal Nerve / surgery

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  • (PMID = 18253695.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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41. Yonekawa Y: [On the occasion of my retirement as head of the Neurochirurgische Universitätsklinik Zürich--changing aspects of treatment modality in modern neurosurgery and of neuroscience research. Presentation of our experience and historical backgrounds]. Brain Nerve; 2008 May;60(5):538-46
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  • Traditionally, carotid endarterectomy belonged to vascular surgeons in our hospital, but the tendency of conversion from conventional carotid endarterectomy to endovascular PTA and/or stenting seemed to be marked, while microvascular revascularization procedure represented by extracranial intracranial EC-IC bypass remained constant (around 20/year) in various occasion (277 times on 203 cases: atherosclerosis 93, Moyamoya angiopathy (MMA) 47, aneurysm 57 and skull base tumour 6, during the last 13 years], in spite of negative results of EC-IC bypass international cooperative study for stroke prevention in 1985.
  • Acoustic neurinoma (just less than 20/year) is one of benign brain tumours whose treatment has changed remarkably.
  • Thanks to development of intaroperative neurophysiological monitoring and of surgical technique, preservation of facial nerve function has improved from 60% to more than 85% in spite of the increase of size.
  • [MeSH-minor] Brain Neoplasms / surgery. Cerebral Revascularization / methods. Cerebral Revascularization / trends. Humans. Hydrocephalus / surgery. Intracranial Aneurysm / surgery. Intracranial Arteriovenous Malformations / surgery. Switzerland. Universities

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  • (PMID = 18516976.001).
  • [ISSN] 1881-6096
  • [Journal-full-title] Brain and nerve = Shinkei kenkyū no shinpo
  • [ISO-abbreviation] Brain Nerve
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 33
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42. Marouf R, Noudel R, Roche PH: Facial nerve outcome after microsurgical resection of vestibular schwannoma. Prog Neurol Surg; 2008;21:103-7
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  • [Title] Facial nerve outcome after microsurgical resection of vestibular schwannoma.
  • The risk of facial nerve palsy after microsurgical removal of vestibular schwannoma cannot be totally eradicated.
  • Taken together, the data from our personal experience and analysis of the literature indicate that the major predictor of postoperative facial deficit is tumor size.
  • When confronted with large tumors, we personally changed our surgical goals and considered that facial nerve conservation and tumor control are interconnected priorities instead of radical removal.
  • [MeSH-major] Facial Nerve Injuries / epidemiology. Facial Nerve Injuries / prevention & control. Facial Paralysis / epidemiology. Facial Paralysis / prevention & control. Microsurgery / adverse effects. Neuroma, Acoustic / surgery

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  • (PMID = 18810207.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 23
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43. Foroughi M, Pitkäniemi J, Nannapaneni R, Nath F: Excision of vestibular schwannomas--is there a learning curve and how best to demonstrate it? Br J Neurosurg; 2010 Oct;24(5):547-54
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  • [Title] Excision of vestibular schwannomas--is there a learning curve and how best to demonstrate it?
  • OBJECTIVE: To demonstrate the existence of a learning curve in a consultant neurosurgeon's performance in excising vestibular schwannomas by plotting the cumulative sum (CUSUM) chart.
  • Also, to evaluate the influence of new technology in the form of the facial nerve monitor (FNM) and the KTP-532 Laser on surgical performance.
  • METHOD: Analysis was carried out on a prospectively collected data series of 102 consecutive cases of vestibular schwannomas excisions between 1986 and 2000 by a single neurosurgeon using the retrosigmoid approach.
  • [MeSH-major] Clinical Competence / standards. Facial Nerve / surgery. Learning Curve. Neuroma, Acoustic / surgery. Neurosurgical Procedures / standards

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  • (PMID = 20868242.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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44. Herwadker A, Vokurka EA, Evans DG, Ramsden RT, Jackson A: Size and growth rate of sporadic vestibular schwannoma: predictive value of information available at presentation. Otol Neurotol; 2005 Jan;26(1):86-92
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  • [Title] Size and growth rate of sporadic vestibular schwannoma: predictive value of information available at presentation.
  • BACKGROUND: The current study examines the hypothesis that tumor growth rate in sporadic vestibular schwannoma could be in part predicted by data available at diagnosis, such as tumor volume, patient age, laterality, and sex.
  • METHODS: Tumor volumes and growth rates were calculated from serial magnetic resonance imaging data in a cohort of 50 patients (26 men and 24 women; mean age at presentation, 64.1 +/- 12.8 yr).
  • Tumor volumes were measured using an algorithm that corrects for partial volume averaging errors and provides accurate estimates of tumor volume with known errors.
  • RESULTS: Examination of presentation data showed no relationship between tumor size at diagnosis and patient age, sex, or tumor laterality.
  • Two measurements of tumor growth--absolute growth per annum and tumor volume doubling time--were studied, and neither showed any relationship with tumor size at presentation, patient age, tumor laterality, or sex.
  • This indicates that the clinical features available at presentation and diagnosis have no power to predict the expected behavior of sporadic vestibular schwannoma.
  • [MeSH-major] Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Neuroma, Acoustic / diagnosis. Tumor Burden / physiology
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Algorithms. Cohort Studies. Disease Progression. Dominance, Cerebral / physiology. Female. Follow-Up Studies. Humans. Male. Middle Aged

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  • (PMID = 15699725.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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45. Tufarelli D, Meli A, Alesii A, De Angelis E, Badaracco C, Falcioni M, Sanna M: Quality of life after acoustic neuroma surgery. Otol Neurotol; 2006 Apr;27(3):403-9
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  • [Title] Quality of life after acoustic neuroma surgery.
  • OBJECTIVE: The aim of this study is to assess patients' quality of life after acoustic neuroma surgery, and if some patients' characteristics, parameters of tumor and surgical parameters affect patients' quality of life.
  • PATIENTS: A group of 386 patients who underwent acoustic neuroma surgery.
  • INTERVENTION: Patients included were derived from a population of 459 subjects operated for acoustic neuroma by the Otologic Group of Piacenza.
  • Our data indicate that an early surgical approach for intrameatal tumor is better than waiting for an increase in the tumor size.
  • A "wait-and-scan" strategy for extrameatal neuromas which do not affect the brainstem is preferable, since these patients have a worsening of their quality of life after surgery independently of the tumor size.
  • [MeSH-major] Neuroma, Acoustic / surgery. Postoperative Complications / psychology. Quality of Life

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  • (PMID = 16639281.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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46. Lagerwaard FJ, Meijer OW, van der Hoorn EA, Verbakel WF, Slotman BJ, Senan S: Volumetric modulated arc radiotherapy for vestibular schwannomas. Int J Radiat Oncol Biol Phys; 2009 Jun 1;74(2):610-5
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  • [Title] Volumetric modulated arc radiotherapy for vestibular schwannomas.
  • PURPOSE: To evaluate volumetric modulated arc radiotherapy (RapidArc [RA]), a novel approach allowing for rapid treatment delivery, for the treatment of vestibular schwannoma (VS).
  • A superior CI was achieved with RA, with a substantial decrease in low-dose irradiation of the normal brain achieved relative to 5DCA plans.
  • [MeSH-major] Neuroma, Acoustic / radiotherapy. Radiotherapy Planning, Computer-Assisted / methods. Radiotherapy, Intensity-Modulated / methods
  • [MeSH-minor] Algorithms. Humans. Neoplasms, Radiation-Induced / prevention & control. Neoplasms, Second Primary / prevention & control. Phantoms, Imaging. Radiosurgery. Radiotherapy Dosage. Trigeminal Nerve / radiation effects. Tumor Burden

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  • (PMID = 19427560.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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47. Plotkin SR, Halpin C, McKenna MJ, Loeffler JS, Batchelor TT, Barker FG 2nd: Erlotinib for progressive vestibular schwannoma in neurofibromatosis 2 patients. Otol Neurotol; 2010 Sep;31(7):1135-43
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  • [Title] Erlotinib for progressive vestibular schwannoma in neurofibromatosis 2 patients.
  • We sought to determine the activity of erlotinib for progressive vestibular schwannoma (VS) associated with neurofibromatosis 2 (NF2).
  • MAIN OUTCOME MEASURES: A radiographic response was defined as >or= 20% decrease in tumor volume compared with baseline.
  • Among 10 evaluable patients, the median time-to-tumor progression was 9.2 months.
  • Three patients with stable disease experienced maximum tumor shrinkage of 4%, 13%, and 14%.
  • The median time-to-progressive hearing loss was 9.2 months and to either tumor growth or progressive hearing loss was 7.1 months.
  • CONCLUSION: Erlotinib treatment was not associated with radiographic or hearing responses in NF2 patients with progressive vs. Because a subset of patients experienced prolonged stable disease, time-to-progression may be more appropriate than radiographic or hearing response for anti-EGFR agents in NF2-associated vs.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Neurofibromatosis 2 / drug therapy. Neuroma, Acoustic / drug therapy. Quinazolines / therapeutic use
  • [MeSH-minor] Adolescent. Adult. Audiometry, Pure-Tone. Disease Progression. Erlotinib Hydrochloride. Female. Hearing Loss, Sensorineural / complications. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Speech Perception / physiology. Treatment Outcome. Young Adult

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  • (PMID = 20736812.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / P01 NS024279; United States / NINDS NIH HHS / NS / P01 NS024279-23; United States / NIDCD NIH HHS / DC / R01 DC009837
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Quinazolines; DA87705X9K / Erlotinib Hydrochloride
  • [Other-IDs] NLM/ NIHMS570073; NLM/ PMC4030413
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48. Aihara N, Murakami S, Watanabe N, Takahashi M, Inagaki A, Tanikawa M, Yamada K: Cochlear nerve action potential monitoring with the microdissector in vestibular schwannoma surgery. Skull Base; 2009 Sep;19(5):325-32
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  • [Title] Cochlear nerve action potential monitoring with the microdissector in vestibular schwannoma surgery.
  • We developed a cochlear nerve action potential (CNAP) monitoring technique using a microdissector and compared the results of CNAP and auditory brainstem response (ABR) monitoring.
  • Thirty-six patients underwent vestibular schwannoma resection via the retrosigmoid approach to preserve hearing.
  • We used the microdissector as an intracranial electrode for CNAP monitoring.
  • At the completion of the tumor resection, the triphasic waveform was observed in 11 patients and the biphasic waveform was observed in 11 patients.

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  • (PMID = 20190942.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2765700
  • [Keywords] NOTNLM ; auditory brainstem response / cochlear nerve action potential / microdissector / vestibular schwannoma
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49. Stieglitz LH, Wrede KH, Gharabaghi A, Gerganov VM, Samii A, Samii M, Luedemann WO: Factors affecting postoperative cerebrospinal fluid leaks after retrosigmoidal craniotomy for vestibular schwannomas. J Neurosurg; 2009 Oct;111(4):874-83
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  • [Title] Factors affecting postoperative cerebrospinal fluid leaks after retrosigmoidal craniotomy for vestibular schwannomas.
  • OBJECT: The aim of this study was to identify patients likely to develop CSF leaks after vestibular schwannoma surgery using a retrospective analysis for the identification of risk factors.
  • METHODS: Between January 2001 and December 2006, 420 patients underwent retrosigmoidal microsurgical tumor removal in a standardized procedure.
  • Of these 420 patients, 363 underwent treatment for the first time, and 27 suffered from recurrent tumors.
  • Twenty-six patients had bilateral tumors due to neurofibromatosis Type 2, and 4 patients had previously undergone radiosurgical treatment.
  • RESULTS: The incidence of CSF leakage was higher in the tumor recurrence group (11.1%) than in patients undergoing surgery for the first time (4.4%).
  • Tumor size was identified as a possible risk factor in a previous study.
  • CONCLUSIONS: Surgery for recurrent tumors is a significant risk factor for the development of CSF leaks.
  • [MeSH-major] Craniotomy / adverse effects. Craniotomy / methods. Neuroma, Acoustic / surgery. Subdural Effusion / etiology

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  • (PMID = 19326990.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 42
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50. Peñarrocha-Diago M, Mora-Escribano E, Bagán JV, Peñarrocha-Diago M: Neoplastic trigeminal neuropathy: presentation of 7 cases. Med Oral Patol Oral Cir Bucal; 2006 Mar;11(2):E106-11
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  • We present 7 cases of trigeminal neuropathy secondary to tumors: in four cases there were antecedents of systemic neoplastic disease, while in the remaining three cases neuropathy was the first manifestation of the tumor.
  • The lesion was located in the mandible in three cases, in the region of the skull base in one patient, and in the brainstem and brain in one case each.
  • Recovery was only recorded in one patient in whom the symptoms were seen to disappear after acoustic nerve neurinoma resection.
  • The lesions underlying neoplastic trigeminal neuropathy can be located at any point along the trajectory of the trigeminal nerve, and their prognosis is very poor.
  • [MeSH-major] Cranial Nerve Neoplasms / complications. Cranial Nerve Neoplasms / diagnosis. Trigeminal Nerve Diseases / diagnosis. Trigeminal Nerve Diseases / etiology

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  • (PMID = 16505784.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Journal Article
  • [Publication-country] Spain
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51. Boisson-Bertrand D, Laxenaire MC, Mertes PM: Recovery after prolonged anaesthesia for acoustic neuroma surgery: desflurane versus isoflurane. Anaesth Intensive Care; 2006 Jun;34(3):338-42
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  • [Title] Recovery after prolonged anaesthesia for acoustic neuroma surgery: desflurane versus isoflurane.
  • In this study, 33 patients were randomly assigned to receive desflurane (D) or isoflurane (I) for acoustic neuroma surgery.
  • The results indicate that desflurane is associated with similar operating conditions and faster postoperative recovery following acoustic neuroma surgery.
  • [MeSH-major] Anesthesia Recovery Period. Anesthesia, Inhalation. Anesthetics, Inhalation. Isoflurane / analogs & derivatives. Neuroma, Acoustic / surgery

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  • (PMID = 16802487.001).
  • [ISSN] 0310-057X
  • [Journal-full-title] Anaesthesia and intensive care
  • [ISO-abbreviation] Anaesth Intensive Care
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Anesthetics, Inhalation; CRS35BZ94Q / desflurane; CYS9AKD70P / Isoflurane
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52. Dublin A: Acoustic neuroma or vestibular schwannoma? Skull Base; 2009 Sep;19(5):375
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  • [Title] Acoustic neuroma or vestibular schwannoma?

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  • (PMID = 20190950.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2765706
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53. Aghi M, Barker FG 2nd: Benign adult brain tumors: an evidence-based medicine review. Prog Neurol Surg; 2006;19:80-96
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign adult brain tumors: an evidence-based medicine review.
  • BACKGROUND: Benign adult brain tumors can be managed conservatively or using surgery, radiation, or medicines.
  • While randomized comparisons assessing tumor recurrence, quality of life, or survival are the ideal means of comparing treatments, it can be difficult to recruit patients to such trials and lengthy follow-up periods are needed because of the slowly progressive natural history of these tumors.
  • METHODS: Review of the literature on benign adult brain tumors using evidence-based standards and focusing on meningiomas, pituitary adenomas, and vestibular schwannomas, which together represent the majority of WHO grade 1 adult brain tumors.
  • RESULTS: Nearly all studies of benign adult brain tumors were of relatively poor quality (level 3 or poorer).
  • Vestibular schwannomas can be conservatively managed, but there are no reliable predictors of growth, so serial imaging is important.
  • Radiosurgery has proven to be a reliable alternative to surgery for small to medium-sized vestibular schwannomas, but followup has been relatively short in most studies to date.
  • CONCLUSIONS: While randomized clinical trials comparing conservative management, surgery, radiation, and medical management of benign adult benign tumors are unlikely to occur, there is some level 3 evidence that can assist in their treatment.
  • [MeSH-major] Brain Neoplasms / therapy. Evidence-Based Medicine
  • [MeSH-minor] Adenoma / therapy. Adult. Humans. Meningeal Neoplasms / therapy. Meningioma / therapy. Neuroma, Acoustic / therapy. Neurosurgical Procedures. Phototherapy. Pituitary Neoplasms / therapy. Radiosurgery

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  • (PMID = 17033148.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 58
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54. Dumas G, De Waele C, Hamann KF, Cohen B, Negrevergne M, Ulmer E, Schmerber S: [Skull vibration induced nystagmus test]. Ann Otolaryngol Chir Cervicofac; 2007 Sep;124(4):173-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Le test vibratoire osseux vestibulaire.
  • Total unilateral peripheral lesions (tUVL: operated vestibular shwannomas, vestibular neurectomies) and partial unilateral peripheral lesions (pUVL: preoperative neuromas, Meniere's disease, vestibular neuritis, chemical labyrinthectomies) were studied.
  • SVINT is positive in 6 to 10% of the normal population, 31% of brain stem lesions and negative in total bilateral vestibular peripheral lesions.
  • CONCLUSIONS: SVINT is an effective, rapid and non invasive test used to detect vestibular asymmetry between 20 to 150 Hz stimulation.
  • SVINT is useful in the diagnosis of labyrinthine hydrops or detection of acoustic neuromas.
  • This test does not precisely point out the level of the lesion on the vestibular pathway.
  • [MeSH-minor] Adult. Aged. Caloric Tests. Edema / diagnosis. Edema / epidemiology. False Positive Reactions. Female. Humans. Male. Mastoid. Meniere Disease / diagnosis. Meniere Disease / epidemiology. Middle Aged. Neuroma, Acoustic / diagnosis. Neuroma, Acoustic / epidemiology. Prevalence. Sensitivity and Specificity. Severity of Illness Index. Skull / physiology. Vestibular Diseases / diagnosis. Vestibular Diseases / epidemiology. Vestibular Neuronitis / diagnosis. Vestibular Neuronitis / epidemiology

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  • (PMID = 17678612.001).
  • [ISSN] 0003-438X
  • [Journal-full-title] Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris
  • [ISO-abbreviation] Ann Otolaryngol Chir Cervicofac
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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55. Cheng S, Naidoo Y, da Cruz M, Dexter M: Quality of life in postoperative vestibular schwannoma patients. Laryngoscope; 2009 Nov;119(11):2252-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Quality of life in postoperative vestibular schwannoma patients.
  • OBJECTIVES/HYPOTHESIS: To quantify the postoperative quality of life (QOL) in patients following vestibular schwannoma surgery in a new multidisciplinary skull base unit.
  • METHODS: The Australian Short Form 36 (SF-36) quality of life health questionnaire was administered to 121 consecutive patients surgically treated for vestibular schwannoma between 1999 and 2007 at Westmead Hospital, New South Wales, Australia.
  • The postoperative QOL in vestibular schwannoma patients was significantly less than the appropriate matched healthy Australian population in one health domain of role physical limitation (P < .05).
  • Analysis of preoperative patient factors (age, gender) and surgical factors such as tumor size (cutoff points of 15 mm or 25 mm) together with, surgical approach (translabyrinthine and retrosigmoid) showed no significant difference in QOL outcomes for each of these variables (P < .05).
  • CONCLUSIONS: Results indicate that patients following vestibular schwannoma surgery reported near equivalent QOL as the healthy population.
  • Advances in surgical techniques and experiences have minimized morbidities associated with vestibular schwannoma surgery.
  • Significant physical role limitation encountered postoperatively may relate to facial nerve dysfunction, vestibular dysfunction, tinnitus or hearing loss that may persist after surgery.
  • A measured approach should still be considered for patients with small, slow growing tumors with minimal symptoms.
  • [MeSH-major] Neuroma, Acoustic / surgery. Quality of Life

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  • (PMID = 19753619.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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56. Lassaletta L, Gavilán J: [An update on the treatment of vestibular schwannoma]. Acta Otorrinolaringol Esp; 2009 Mar-Apr;60(2):131-40
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  • [Title] [An update on the treatment of vestibular schwannoma].
  • [Transliterated title] Actualización en el tratamiento del schwannoma vestibular.
  • The increase in the diagnosis of ever smaller vestibular schwannomas (VS), the fact that many tumours can be observed with serial MRI, and the development of radiosurgery as an alternative to microsurgery have led the neurotologic surgeon to a new global approach to patients with vs. On the other hand, the spread of internet-based information sources, often with biased or incomplete information, makes counselling patients with VS a challenging task.
  • [MeSH-major] Neuroma, Acoustic / therapy
  • [MeSH-minor] Disease Progression. Humans. Otologic Surgical Procedures / methods. Radiosurgery

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  • (PMID = 19401081.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 50
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57. Scarlett A, Bird P, Macfarlane M: Conductive hearing loss after removal of acoustic neuroma. Otol Neurotol; 2008 Jun;29(4):553-6
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  • [Title] Conductive hearing loss after removal of acoustic neuroma.
  • OBJECTIVE: To report 4 patients who have developed a conductive and/or mixed hearing loss due to dehiscence of the inner ear after retrosigmoid approach for removal of acoustic neuroma.
  • PATIENTS: Four patients who presented with conductive and/or mixed hearing loss after retrosigmoid approach for removal of acoustic neuroma.
  • CONCLUSION: The occurrence of conductive hearing loss after the surgical removal of an acoustic neuroma has not previously been documented.
  • Computed tomographic scan of the temporal bones showing inner ear dehiscence may explain this finding.
  • [MeSH-major] Cranial Nerve Neoplasms / complications. Cranial Nerve Neoplasms / surgery. Hearing Loss, Conductive / etiology. Hearing Loss, Conductive / physiopathology. Neuroma, Acoustic / complications. Neuroma, Acoustic / surgery. Postoperative Complications / physiopathology. Vestibulocochlear Nerve Diseases / complications. Vestibulocochlear Nerve Diseases / surgery
  • [MeSH-minor] Acoustic Impedance Tests. Adult. Aged. Audiometry. Female. Hearing Aids. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Otologic Surgical Procedures. Otoscopy. Petrous Bone / pathology. Speech Perception. Tomography, X-Ray Computed


58. Lenarz M, Lim HH, Patrick JF, Anderson DJ, Lenarz T: Electrophysiological validation of a human prototype auditory midbrain implant in a guinea pig model. J Assoc Res Otolaryngol; 2006 Dec;7(4):383-98
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  • This includes neurofibromatosis type II (NF2) patients who, due to development and/or removal of vestibular schwannomas, usually experience complete damage of their auditory nerves.

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  • (PMID = 17075701.001).
  • [ISSN] 1525-3961
  • [Journal-full-title] Journal of the Association for Research in Otolaryngology : JARO
  • [ISO-abbreviation] J. Assoc. Res. Otolaryngol.
  • [Language] ENG
  • [Grant] United States / NIBIB NIH HHS / EB / P41 EB002030; United States / NIDCD NIH HHS / DC / P30 DC005188; United States / NIBIB NIH HHS / EB / P41 EB2030; United States / NIDCD NIH HHS / DC / F31 DC007009; United States / NIDCD NIH HHS / DC / T32 DC00011; United States / NIDCD NIH HHS / DC / P30 DC05188; United States / NIDCD NIH HHS / DC / T32 DC000011
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Validation Studies
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2504634
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59. Browne S, Distel E, Morton RP, Petrie KJ: Patients' quality of life, reported difficulties, and benefits following surgery for acoustic neuroma. J Otolaryngol Head Neck Surg; 2008 Jun;37(3):417-22
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  • [Title] Patients' quality of life, reported difficulties, and benefits following surgery for acoustic neuroma.
  • OBJECTIVES: We compared the quality of life of patients with acoustic neuroma (AN) with general population controls and other chronic illness patients.
  • METHODS: A research questionnaire was sent to all 119 members of the Acoustic Neuroma Association of New Zealand.
  • However, most AN patients do report finding some benefit from their illness experience.
  • [MeSH-major] Hearing / physiology. Neuroma, Acoustic / psychology. Otologic Surgical Procedures / methods. Quality of Life

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  • (PMID = 19128648.001).
  • [ISSN] 1916-0216
  • [Journal-full-title] Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
  • [ISO-abbreviation] J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Canada
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60. Lahkola A, Tokola K, Auvinen A: Meta-analysis of mobile phone use and intracranial tumors. Scand J Work Environ Health; 2006 Jun;32(3):171-7
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  • [Title] Meta-analysis of mobile phone use and intracranial tumors.
  • OBJECTIVES: A summary of epidemiologic evidence regarding the effect of mobile phone use on intracranial tumor risk was obtained by means of a meta-analysis.
  • METHODS: Reports of published studies on mobile phone use and intracranial tumors were sought.
  • A pooled estimate was calculated for all intracranial tumors combined and also separately for different histological tumor types.
  • Separate analyses were conducted also based on the tumor location and type of mobile telephone network (NMT or GSM).
  • RESULTS: Twelve studies with 2780 cases gave a pooled odds ratio (OR) of 0.98 [95% confidence interval (95% CI) 0.83-1.16] for all intracranial tumors related to mobile phone use.
  • For gliomas, the pooled OR was 0.96 (95% CI 0.78-1.18), for meningiomas it was 0.87 (95% CI 0.72-1.05), and for acoustic neuromas it was 1.07 (95% CI 0.89-1.30).
  • Little indication was found for increased risks of analogue or digital phone use or temporal or occipital tumors.
  • CONCLUSIONS: The totality of evidence does not indicate a substantially increased risk of intracranial tumors from mobile phone use for a period of at least 5 years.
  • [MeSH-major] Brain Neoplasms / etiology. Cell Phones

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  • [CommentIn] Scand J Work Environ Health. 2006 Jun;32(3):169-70 [16804617.001]
  • (PMID = 16804618.001).
  • [ISSN] 0355-3140
  • [Journal-full-title] Scandinavian journal of work, environment & health
  • [ISO-abbreviation] Scand J Work Environ Health
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] Finland
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61. Morimoto Y, Sakabe T: [Auditory evoked potentials]. Masui; 2006 Mar;55(3):314-21
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  • Auditory evoked potentials (AEPs) are an electrical manifestation of the brain response to an auditory stimulus.
  • These waves are called the brain stem auditory evoked potentials (BAEPs) or the auditory brain stem response (ABR).
  • The BAEPs are useful during the microvascular decompression of the fifth or seventh cranial nerve, resection of acoustic neuroma and posterior fossa operations.
  • [MeSH-major] Evoked Potentials, Auditory. Evoked Potentials, Auditory, Brain Stem / physiology. Monitoring, Intraoperative / methods
  • [MeSH-minor] Anesthesia. Anesthetics / pharmacology. Auditory Pathways / physiology. Body Temperature. Brain Diseases / surgery. Humans. Reaction Time

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  • (PMID = 16541780.001).
  • [ISSN] 0021-4892
  • [Journal-full-title] Masui. The Japanese journal of anesthesiology
  • [ISO-abbreviation] Masui
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anesthetics
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62. Sandooram D, Hornigold R, Grunfeld B, Thomas N, Kitchen ND, Gleeson M: The Effect of Observation versus Microsurgical Excision on Quality of Life in Unilateral Vestibular Schwannoma: A Prospective Study. Skull Base; 2010 Jan;20(1):47-54
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  • [Title] The Effect of Observation versus Microsurgical Excision on Quality of Life in Unilateral Vestibular Schwannoma: A Prospective Study.
  • With the emergence of three effective management options for vestibular schwannoma and the drastic reduction in mortality rate, the last two decades have seen increasing attention being paid to health-related quality of life.
  • We prospectively assessed quality of life of vestibular schwannoma patients before and after conservative or microsurgical management.
  • The improved quality of life of patients 6 months after microsurgery (relative to preoperatively, and in comparison with an age- and sex- matched population) is a new finding that has not been previously documented in the literature.

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  • (PMID = 20592858.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2853062
  • [Keywords] NOTNLM ; Glasgow Benefit Inventory / SF-36 / Vestibular schwannoma / acoustic neuroma / quality of life
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63. Coez A, Zilbovicius M, Ferrary E, Bouccara D, Mosnier I, Ambert-Dahan E, Kalamarides M, Bizaguet E, Syrota A, Samson Y, Sterkers O: Processing of voices in deafness rehabilitation by auditory brainstem implant. Neuroimage; 2009 Oct 1;47(4):1792-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Profound acquired deafness by post-meningitis ossified cochlea and by bilateral vestibular schwannoma in neurofibromatosis type 2 patients are two indications for auditory brainstem implantation (ABI).
  • ABI allowed the transmission of sound stimuli to temporal brain regions but lacked transmitting the specific cues of the human voice to the TVA.
  • Moreover, among groups, during silent condition, brain visual regions showed higher rCBF in ABI group, although temporal brain regions had higher rCBF in the controls group.
  • [MeSH-major] Auditory Brain Stem Implantation / instrumentation. Auditory Cortex / physiology. Auditory Perception. Brain Mapping / methods. Deafness / physiopathology. Deafness / rehabilitation. Evoked Potentials, Auditory


64. Otto M, von Mühlendahl KE: Electromagnetic fields (EMF): do they play a role in children's environmental health (CEH)? Int J Hyg Environ Health; 2007 Oct;210(5):635-44
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  • Final results of the INTERPHONE study on the risk of brain tumours, acoustic neurinoma and parotid gland tumours associated with the use of mobile phones will be soon available.
  • [MeSH-minor] Cell Phones. Child. Humans. Leukemia, Radiation-Induced / etiology. Microwaves


65. Hours M, Bernard M, Arslan M, Montestrucq L, Richardson L, Deltour I, Cardis E: Can loud noise cause acoustic neuroma? Analysis of the INTERPHONE study in France. Occup Environ Med; 2009 Jul;66(7):480-6
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  • [Title] Can loud noise cause acoustic neuroma? Analysis of the INTERPHONE study in France.
  • OBJECTIVES: To investigate possible associations between risk of acoustic neuroma and exposure to loud noise in leisure and occupational settings.
  • The cases were the 108 subjects diagnosed with acoustic neuroma between 1 June 2000 and 31 August 2003.
  • RESULTS: Acoustic neuroma was found to be associated with loud noise exposure (odds ratio (OR) = 2.55; 95% CI 1.35 to 4.82), both in leisure settings, particularly when listening to loud music (OR = 3.88; 95% CI 1.48 to 10.17) and at work (OR = 2.26; 95% CI 1.08 to 4.72).
  • CONCLUSION: The present results agree with other recent reports implicating loud noise in the risk of acoustic neuroma.
  • [MeSH-major] Environmental Exposure / adverse effects. Neuroma, Acoustic / etiology. Noise / adverse effects


66. Goodwin L: Acoustic neuroma and radiosurgery. J Insur Med; 2007;39(1):44-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acoustic neuroma and radiosurgery.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / methods. Treatment Outcome

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  • (PMID = 17500357.001).
  • [ISSN] 0743-6661
  • [Journal-full-title] Journal of insurance medicine (New York, N.Y.)
  • [ISO-abbreviation] J Insur Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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67. Plaut J, Galloway M, Childerhouse A, Bradford R: Schwannoma with monoclonal plasma cell infiltration. J Neurosurg; 2009 Sep;111(3):509-11
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  • [Title] Schwannoma with monoclonal plasma cell infiltration.
  • The authors report a very rare case of a vestibular schwannoma with an infiltrate of monoclonal plasma cells.
  • A 45-year-old woman underwent routine excision of a presumed vestibular schwannoma.
  • Histological analysis revealed the presence of a distinct lambda light chain restricted plasma cell population within the schwannoma.
  • The light chain restriction and polymerase chain reaction-demonstrated monoclonality of the plasma cell population suggested the co-occurrence of a plasma cell neoplasm within a schwannoma.
  • A search for systemic disease of plasma cell origin was unremarkable.
  • [MeSH-major] Neuroma, Acoustic / pathology. Plasma Cells / pathology

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  • (PMID = 19374503.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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68. Mathai KI, Sengupta SK, Shashivadhanan, Khanna V, Sudumbrekar SM, Sahoo PK: Hearing Preservation in a Case of Acoustic Schwannoma. Med J Armed Forces India; 2009 Jul;65(3):290-1
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  • [Title] Hearing Preservation in a Case of Acoustic Schwannoma.

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  • (PMID = 27408274.001).
  • [ISSN] 0377-1237
  • [Journal-full-title] Medical journal, Armed Forces India
  • [ISO-abbreviation] Med J Armed Forces India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC4921402
  • [Keywords] NOTNLM ; Acoustic schwannoma / Hearing conservation
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69. Park KY, Ahn JY, Lee JW, Chang JH, Huh SK: De novo intracranial aneurysm formation after Gamma Knife radiosurgery for vestibular schwannoma. J Neurosurg; 2009 Mar;110(3):540-2
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  • [Title] De novo intracranial aneurysm formation after Gamma Knife radiosurgery for vestibular schwannoma.
  • Vascular complications, including vessel occlusion and hemorrhage, can arise after radiosurgery; however, hemorrhage due to a ruptured de novo aneurysm after Gamma Knife radiosurgery (GKS) for tumor is extremely rare.
  • To the authors' knowledge, only a single case of de novo aneurysm formation after GKS for vestibular schwannoma has been previously reported.
  • In this study, they describe their experience with the treatment of a 74-year-old woman with subarachnoid hemorrhage limited to the cerebellopontine cistern, who had undergone GKS for vestibular schwannoma 5 years earlier.
  • [MeSH-major] Cerebellar Diseases / etiology. Intracranial Aneurysm / etiology. Neuroma, Acoustic / surgery. Radiosurgery / adverse effects


70. Evans DG, Watson C, King A, Wallace AJ, Baser ME: Multiple meningiomas: differential involvement of the NF2 gene in children and adults. J Med Genet; 2005 Jan;42(1):45-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Lymphocyte or tumour DNA was analysed from 46 individuals from 36 families who presented with a meningioma at age < or =15 years without vestibular schwannoma (VS), or who had multiple meningiomas in adulthood before the diagnosis of vs.
  • [MeSH-major] Genes, Neurofibromatosis 2. Meningioma / genetics. Mutation. Neuroma, Acoustic / genetics. Point Mutation

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  • (PMID = 15635074.001).
  • [ISSN] 1468-6244
  • [Journal-full-title] Journal of medical genetics
  • [ISO-abbreviation] J. Med. Genet.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1735900
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71. Friedman WA, Bradshaw P, Myers A, Bova FJ: Linear accelerator radiosurgery for vestibular schwannomas. J Neurosurg; 2006 Nov;105(5):657-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Linear accelerator radiosurgery for vestibular schwannomas.
  • OBJECT: Radiosurgery has become a popular treatment for small vestibular schwannomas (VSs).
  • Multivariate and actuarial statistics were used to analyze rates of local tumor control and complications, including facial and trigeminal neuropathies, after treatment.
  • Only four patients (1%) required surgery for tumor growth.
  • The risk of these complications rose with increasing tumor volume or increasing radiosurgical dose to the tumor periphery.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery

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  • [CommentIn] J Neurosurg. 2006 Nov;105(5):655-6; discussion 656 [17121122.001]
  • (PMID = 17121123.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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72. Lustgarten L: Use of Bioglue in translabyrinthine vestibular schwannoma surgery. Otol Neurotol; 2007 Oct;28(7):992
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Use of Bioglue in translabyrinthine vestibular schwannoma surgery.
  • [MeSH-major] Bone Cements. Cranial Nerve Neoplasms / surgery. Neuroma, Acoustic / surgery. Otologic Surgical Procedures. Vestibulocochlear Nerve Diseases / surgery

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  • [CommentOn] Otol Neurotol. 2006 Jan;27(1):102-5 [16371855.001]
  • (PMID = 17909439.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Cements
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73. Swartz JD: Pathology of the vestibulocochlear nerve. Neuroimaging Clin N Am; 2008 May;18(2):321-46, x-xi
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  • [Title] Pathology of the vestibulocochlear nerve.
  • Imaging of the vestibulocochlear nerve has evolved dramatically over the past few decades.
  • This article is organized in a conventional way and covers congenital deformity of the internal auditory canal, neoplastic and pseudoneoplastic lesions, with special detailed emphasis on schwannoma of the eight cranial nerves (acoustic neuroma), nonneoplastic IAC/CPA pathology, including vascular loops, and numerous additional differential diagnostic entities, with particular emphasis on non-neoplastic meningeal disease.
  • [MeSH-major] Cranial Nerve Neoplasms / pathology. Magnetic Resonance Imaging. Vestibulocochlear Nerve Diseases / pathology

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  • (PMID = 18466835.001).
  • [ISSN] 1052-5149
  • [Journal-full-title] Neuroimaging clinics of North America
  • [ISO-abbreviation] Neuroimaging Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 84
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74. Chen CC, Cheng PW, Tseng HM, Young YH: Posterior cranial fossa tumors in young adults. Laryngoscope; 2006 Sep;116(9):1678-81
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  • [Title] Posterior cranial fossa tumors in young adults.
  • OBJECTIVE/HYPOTHESIS: This retrospective study presents our experience on the posterior cranial fossa tumors in young adults during the past 15 years.
  • METHODS: From 1991 to 2005, 16 (0.8%) of 2,091 young adults (range, 16-29 years) with dizziness/vertigo, hearing loss, or tinnitus were diagnosed with posterior fossa tumor.
  • Diagnoses consisted of vestibular schwannoma and neurofibromatosis II in eight patients (50%), glial neoplasm (including astrocytoma, ependymoma, glioma) in four patients (25%), epidermoid cyst in three patients, and glomus jugulare tumor in one patient.
  • At study close, excluding one lost patient, three patients died as a result of recurrent or residual tumor at the primary site.
  • CONCLUSIONS: Unlike predominant medulloblastoma in children, the most frequent posterior fossa tumor in young adults is vestibular schwannoma and neurofibroma.
  • However, the second most frequent one in young adults is glial neoplasm as opposed to meningioma in adults.

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  • (PMID = 16955003.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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75. Plotkin SR, Singh MA, O'Donnell CC, Harris GJ, McClatchey AI, Halpin C: Audiologic and radiographic response of NF2-related vestibular schwannoma to erlotinib therapy. Nat Clin Pract Oncol; 2008 Aug;5(8):487-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Audiologic and radiographic response of NF2-related vestibular schwannoma to erlotinib therapy.
  • INVESTIGATIONS: Medical and neurological examination, MRI scan of the brain and spinal cord, pure-tone audiometry, NU-6 monosyllabic word test with phoneme scoring, City University of New York topic-related sentences test, noise/voice test of minimal auditory capability battery.
  • DIAGNOSIS: Progressive neurofibromatosis-type-2-related vestibular schwannomas.
  • MANAGEMENT: Annual cranial MRI and audiology, surgical resection of right vestibular schwannoma, high-power behind-the-ear hearing aid, erlotinib therapy for progressive left vestibular schwannoma.
  • [MeSH-minor] Audiometry, Pure-Tone. Auditory Threshold. Combined Modality Therapy. Erlotinib Hydrochloride. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Protein Kinase Inhibitors / administration & dosage. Treatment Outcome. Vestibular Diseases / complications. Vestibular Diseases / drug therapy. Vestibular Diseases / surgery

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  • (PMID = 18560388.001).
  • [ISSN] 1743-4262
  • [Journal-full-title] Nature clinical practice. Oncology
  • [ISO-abbreviation] Nat Clin Pract Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Protein Kinase Inhibitors; 0 / Quinazolines; DA87705X9K / Erlotinib Hydrochloride
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76. Magliulo G, Parrotto D, Gagliardi M: Vestibular evoked myogenic and periocular potentials after vestibular schwannoma surgery. Ann Otol Rhinol Laryngol; 2008 Jan;117(1):11-4
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  • [Title] Vestibular evoked myogenic and periocular potentials after vestibular schwannoma surgery.
  • OBJECTIVES: We analyzed the behavior of preoperative and postoperative vestibular evoked myogenic potentials (VEMPs) and vestibular evoked periocular potentials (VEPPs) in 3 patients who had vestibular schwannoma and underwent modified translabyrinthine surgery.
  • METHODS: We compared VEMPs and VEPPs, measured with both air-conducted (AC) and bone-conducted (BC) stimulations.
  • Vestibular evoked potentials were measured both in the immediate postoperative period and some months later.
  • RESULTS: At the immediate postoperative examination, VEPPs were preserved in all 3 patients with both AC and BC stimulations.
  • In contrast, VEPPs were absent in 2 of our patients with AC stimulation and in 1 patient with BC stimulation.
  • In 1 patient, who had a schwannoma of the inferior vestibular nerve, the preservation of VEPPs and the absence of VEMPs in the immediate postoperative period confirm that the saccule represents the origin of VEMPs.
  • [MeSH-major] Evoked Potentials, Somatosensory / physiology. Muscle, Skeletal / physiopathology. Neuroma, Acoustic / physiopathology. Vestibule, Labyrinth / physiopathology

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  • (PMID = 18254364.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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77. Cadoni G, Cianfoni A, Agostino S, Scipione S, Tartaglione T, Galli J, Colosimo C: Magnetic resonance imaging findings in sudden sensorineural hearing loss. J Otolaryngol; 2006 Oct;35(5):310-6
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  • METHODS: Fifty-four consecutive patients affected by SSNHL were investigated using brain MRI.
  • MRI was performed with an eight-channel phased-array head coil to study the entire audiovestibular pathway and the whole brain.
  • The rest of the brain was studied with a 4 mm axial T(2)-weighted FLAIR sequence.
  • In 6 of 54 cases, the detected abnormality was directly correlated to the clinical picture (2 labyrinthine hemorrhage, 1 cochlear inflammation, 1 acoustic neuroma, 1 arachnoid cyst of the CPA, and 1 case of white matter lesions in the pons, compatible with demyelinating plaques along the central audiovestibular nervous pathway, as the first expression of multiple sclerosis).
  • CONCLUSIONS: An extensive MRI study of the audiovestibular nervous pathway and of the whole brain, pre- and postparamagnetic contrast administration, is recommended to rule out the wide spectrum of abnormalities that can cause SSNHL.
  • [MeSH-minor] Adult. Aged. Arachnoid Cysts / pathology. Audiometry, Pure-Tone. Brain / pathology. Cerebellum / blood supply. Cochlea / pathology. Female. Gadolinium. Humans. Male. Middle Aged. Multiple Sclerosis / pathology. Neuroma, Acoustic / pathology

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  • (PMID = 17049147.001).
  • [ISSN] 0381-6605
  • [Journal-full-title] The Journal of otolaryngology
  • [ISO-abbreviation] J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] AU0V1LM3JT / Gadolinium
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78. Bozorg Grayeli A, Kalamarides M, Fraysse B, Deguine O, Favre G, Martin C, Mom T, Sterkers O: Comparison between intraoperative observations and electromyographic monitoring data for facial nerve outcome after vestibular schwannoma surgery. Acta Otolaryngol; 2005 Oct;125(10):1069-74
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  • [Title] Comparison between intraoperative observations and electromyographic monitoring data for facial nerve outcome after vestibular schwannoma surgery.
  • Determination of stimulation thresholds (STs) below 0.05 mA improves facial prognostic information after vestibular schwannoma (VS) surgery.
  • Intraoperative observations were made concerning adhesion and nerve stretch, and facial function was graded (House-Brackmann classification) at postoperative Days 1 and 8.Facial function at postoperative Days 1 and 8 was related to the intraoperative nerve STs at the brainstem and in the adhesion zone (range 0.01-3 mA for a response > 100 microV).
  • These STs were related to the degree of tumor adhesion and not to the nerve stretch.
  • [MeSH-major] Electromyography / instrumentation. Facial Nerve / pathology. Facial Nerve / physiopathology. Monitoring, Intraoperative / instrumentation. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery

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  • (PMID = 16298788.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Norway
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79. Goutagny S, Bouccara D, Bozorg-Grayeli A, Sterkers O, Kalamarides M: [Neurofibromatosis type 2]. Rev Neurol (Paris); 2007 Sep;163(8-9):765-77
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] La neurofibromatose de type 2.
  • INTRODUCTION: Neurofibromatosis 2 (NF2) is a rare autosomal dominant disease whose hallmark is the development of bilateral vestibular schwannomas.
  • STATE OF THE ART: Other features of NF2 include schwannomas, meningiomas, ependymomas, localized along the central nervous system, schwannomas of the peripheral nerves, cutaneous and ophthalmological manifestations.
  • NF2 can be diagnosed in patients without bilateral vestibular schwannoma with sets of diagnostic criteria.
  • Disease phenotype is variable among patients.
  • Main negative prognostic factors are a young age at onset of symptoms and a high number of tumors at diagnosis.
  • NF2 tumor suppressor gene encodes Merlin/Schwannomin, and is also involved in most sporadic schwannomas and meningiomas.
  • Some authors advocate an early proactive strategy against vestibular schwannoma in order to preserve hearing.
  • When a treatment is advisable, surgery remains the treatment of choice for tumors.
  • [MeSH-minor] Adolescent. Adult. Brain Neoplasms / genetics. Brain Neoplasms / pathology. Child. Child, Preschool. Diagnosis, Differential. Ependymoma / epidemiology. Ependymoma / genetics. Ependymoma / pathology. Female. Genes, Tumor Suppressor. Humans. Male. Middle Aged. Neurilemmoma / genetics. Neurilemmoma / pathology. Prognosis

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  • (PMID = 17878803.001).
  • [ISSN] 0035-3787
  • [Journal-full-title] Revue neurologique
  • [ISO-abbreviation] Rev. Neurol. (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 65
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80. Tong MC, Lam JM, Hu BH, Sanna M: [Clinical experience in 36 cases of using of the extended translabyrinthine technique for the treatment of large acoustic neuromas]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2005 Sep;40(9):705-7
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  • [Title] [Clinical experience in 36 cases of using of the extended translabyrinthine technique for the treatment of large acoustic neuromas].
  • [MeSH-major] Fenestration, Labyrinth / methods. Neuroma, Acoustic / surgery

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  • (PMID = 16335411.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Journal Article
  • [Publication-country] China
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81. Xu J, Huang W, Liu G, Zhou J, Gao B: [Patterns of hearing disorders in normal otoacoustic emissions]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2005 Nov;19(22):1023-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHOD: Tests of pure tone audiometry, acoustic impedance test, auditory brainstem response (ABR), 40 Hz AERP,spontaneous otoacoustic emissions (SOAE), transient evoked otoacoustic emissions (TEOAE), distortion evoked otoacoustic emissions (DPEOAE)and imaging examinations of CT/MRI scan were performed on all 83 patients with hearing disorders.
  • (2) 2 patients with unilateral acoustic neuroma;.

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  • (PMID = 16468152.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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82. Engh JA, Kostov D, St Martin MB, Yeaney G, Rothfus W, Hirsch B, Kassam AB: Cavernous malformation tumors: a case study and review of the literature. Otol Neurotol; 2010 Feb;31(2):294-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cavernous malformation tumors: a case study and review of the literature.
  • METHODS: A systematic literature review on cavernous malformations of the cerebellopontine angle yielded 14 case reports relevant to the disease.
  • RESULTS: The most common clinical signs associated with this tumor are hearing loss (86.7%), followed by facial paresis (53.8%).
  • Cavernous malformations range from isointense to hyperintense to brain on noncontrasted T1 magnetic resonance imaging.
  • In general, outcomes for patients with this tumor are favorable, with most patients cured by surgical resection.
  • An understanding of the clinical and radiographic differences between this lesion and a vestibular schwannoma helps to minimize perioperative morbidity.
  • Surgical resection should be performed with special attention to preserving facial nerve function.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Cerebellopontine Angle / pathology. Cerebellopontine Angle / surgery. Intracranial Arteriovenous Malformations / pathology. Intracranial Arteriovenous Malformations / surgery. Otologic Surgical Procedures
  • [MeSH-minor] Adolescent. Facial Paralysis / etiology. Female. Hearing Loss, Sensorineural / etiology. Humans. Magnetic Resonance Imaging. Neuroma, Acoustic / pathology. Postoperative Complications / epidemiology. Treatment Outcome

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  • (PMID = 19887972.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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83. Diallo BK, Franco-Vidal V, Vasili D, Négrevergne M, Darrouzet P, Diouf R, Darrouzet V: [The neurotologic evaluation of vestibular schwannomas. Results of audiological and vestibular testing in 100 consecutive cases]. Rev Laryngol Otol Rhinol (Bord); 2006;127(4):203-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The neurotologic evaluation of vestibular schwannomas. Results of audiological and vestibular testing in 100 consecutive cases].
  • [Transliterated title] L' evaluation neurotologique audio-vestibulaire des schwannomes vestibulaires. A propos de 100 cas.
  • OBJECTIVES: To determine the results and sensitivity of a comprehensive audiological and vestibular work-up in patients presenting with vestibular schwannoma (VS).
  • A comprehensive work-up was conducted in all patients, including pure tone and speech audiometry, Brainstem Evoked Audiologic Potentials (BEAP) assessment, Vestibular Evoked Myogenic Potentials (VEMP) examination and bithermal caloric testing using videonystagmography, on both sides.
  • [MeSH-major] Hearing Loss, Sensorineural / diagnosis. Hearing Loss, Sensorineural / etiology. Neuroma, Acoustic / complications. Neuroma, Acoustic / pathology

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  • (PMID = 17315783.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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84. Gönül E, Izci Y, Onguru O: Arachnoid cyst of the cerebellopontine angle associated with gliosis of the eighth cranial nerve. J Clin Neurosci; 2007 Jul;14(7):700-2
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  • [Title] Arachnoid cyst of the cerebellopontine angle associated with gliosis of the eighth cranial nerve.
  • The clinical syndrome produced by a cyst in the cerebellopontine angle (CPA) may closely mimic that of an acoustic neuroma, with sensorineural hearing loss, impaired corneal reflex, and cerebellar signs with increased intracranial pressure.
  • Gliosis of the eighth nerve is common but its association with CPA arachnoid cyst is very rare and not previously reported.
  • We report a patient with a CPA arachnoid cyst associated with gliosis of the eighth cranial nerve.
  • He presented with right peripheral facial palsy, and gliosis of the eighth nerve was diagnosed intraoperatively.
  • CPA arachnoid cysts should be included in the differential diagnosis of peripheral facial palsy and the eighth cranial nerve should be examined during the resection and fenestration of the arachnoid cyst.
  • [MeSH-major] Arachnoid Cysts / complications. Cerebellar Neoplasms / complications. Cerebellopontine Angle / pathology. Cranial Nerve Neoplasms / complications. Gliosis / complications. Vestibulocochlear Nerve / pathology

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  • (PMID = 17475499.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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85. Vogel JJ, Godefroy WP, van der Mey AG, le Cessie S, Kaptein AA: Illness perceptions, coping, and quality of life in vestibular schwannoma patients at diagnosis. Otol Neurotol; 2008 Sep;29(6):839-45
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  • [Title] Illness perceptions, coping, and quality of life in vestibular schwannoma patients at diagnosis.
  • OBJECTIVE: To evaluate illness perceptions, coping behavior, and quality of life (QOL) in patients with vestibular schwannoma (VS) at diagnosis.
  • RESULTS: The 36-Item Short Form Health Survey scores of VS patients at diagnosis were significantly decreased when compared with healthy controls, patients with head and neck cancer, benign prostate hypertrophy, chronic obstructive pulmonary disease, and deaf patients.
  • CONCLUSION: Vestibular schwannoma patients experience impaired QOL compared with healthy controls and reference groups.
  • [MeSH-major] Adaptation, Psychological. Attitude to Health. Ear Neoplasms / diagnosis. Ear Neoplasms / pathology. Neuroma, Acoustic / diagnosis. Neuroma, Acoustic / psychology. Quality of Life / psychology

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  • (PMID = 18636026.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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86. Otto SR, Shannon RV, Wilkinson EP, Hitselberger WE, McCreery DB, Moore JK, Brackmann DE: Audiologic outcomes with the penetrating electrode auditory brainstem implant. Otol Neurotol; 2008 Dec;29(8):1147-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PATIENTS AND PROTOCOL: In a prospective clinical trial, 10 individuals, all with neurofibromatosis type 2, received a PABI after vestibular schwannoma removal via a translabyrinthine approach.
  • [MeSH-major] Auditory Brain Stem Implants. Deafness / surgery. Hearing Aids. Hearing Tests. Neurofibromatosis 2 / complications. Prostheses and Implants
  • [MeSH-minor] Adult. Cochlear Nerve / physiopathology. Electric Stimulation. Electrodes. Equipment Design. Female. Humans. Male. Middle Aged. Pitch Perception. Treatment Outcome. Young Adult

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  • (PMID = 18931643.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Grant] United States / NIDCD NIH HHS / DC / N01-DC-1-2105; United States / NIDCD NIH HHS / DC / N01-DC-4-0005
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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87. Kakigi A, Nakatani H, Takeda T: Electrocochleographic and pure-tone audiometric findings in contralateral ear of unilateral acoustic neurinoma. ORL J Otorhinolaryngol Relat Spec; 2010;71 Suppl 1:78-84
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  • [Title] Electrocochleographic and pure-tone audiometric findings in contralateral ear of unilateral acoustic neurinoma.
  • OBJECTIVE: Auditory disorders of the contralateral ear in patients with unilateral acoustic neurinoma have previously been reported using the auditory brainstem response.
  • From our survey of the literature, there is no reported result about electrocochleography (ECoG) in the contralateral ear of acoustic neurinoma cases.
  • In the present study, we reported ECoG and pure-tone audiometric results of the contralateral ears in cases of unilateral acoustic neurinoma and the relationship between ECoG findings and tumor size was discussed.
  • METHODS: ECoG and pure-tone audiometry were performed for the contralateral ears in 27 cases of unilateral acoustic neurinoma, and the relationships between tumor size and contralateral ECoG findings and between pure-tone threshold and ECoG findings were investigated.
  • The tumor size was assessed by magnetic resonance imaging.
  • Incidences of abnormal -SP/AP ratio were 30.0% in large tumors (n = 10), 33.3% in mid-size tumors (n = 6) and 18.2% in small tumors (n = 11).
  • There was no correlation between the incidences of abnormal -SP/AP ratio and tumor size.
  • CONCLUSION: These results suggest that any size of acoustic neurinoma may affect contralateral electrocochleographic findings.
  • [MeSH-major] Audiometry, Evoked Response / methods. Audiometry, Pure-Tone. Neuroma, Acoustic / physiopathology

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  • (PMID = 20185954.001).
  • [ISSN] 1423-0275
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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88. Lee TX, Packer MD, Huang J, Akhmametyeva EM, Kulp SK, Chen CS, Giovannini M, Jacob A, Welling DB, Chang LS: Growth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells. Eur J Cancer; 2009 Jun;45(9):1709-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Growth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells.
  • BACKGROUND: Vestibular schwannomas (VS) frequently express high levels of activated AKT.
  • Small-molecule inhibitors of AKT signalling may have therapeutic potential in suppressing the growth of benign VS and malignant schwannomas.
  • METHOD: Primary VS and Schwann cells, human malignant schwannoma HMS-97 cells and mouse Nf2(-/-) Schwann cells and schwannoma cells were prepared to investigate the growth inhibitory and anti-tumour activities of OSU-03012, a celecoxib-derived small-molecule inhibitor of phosphoinositide-dependent kinase-1.
  • Cell proliferation assays, apoptosis, Western blot, in vivo xenograft analysis using SCID mice and immunohistochemistry were performed.
  • RESULTS: OSU-03012 inhibited cell proliferation more effectively in both VS and HMS-97 cells than in normal human Schwann cells.
  • The IC5) of OSU-03012 at 48h was approximately 3.1 microM for VS cells and 2.6 microM for HMS-97 cells, compared with the IC(50) of greater than 12 microM for human Schwann cells.
  • Similarly, mouse Nf2(-/-) schwannoma and Nf2(-/-) Schwann cells were more sensitive to growth inhibition by OSU-03012 than wild-type mouse Schwann cells and mouse schwannoma cells established from transgenic mice carrying the NF2 promoter-driven SV40 T-antigen gene.
  • Like VS cells, malignant schwannoma HMS-97 cells expressed high levels of activated AKT.
  • In vivo xenograft analysis showed that OSU-03012 was well tolerated and inhibited the growth of HMS-97 schwannoma xenografts by 55% after 9 weeks of oral treatment.
  • CONCLUSION: OSU-03012 is a potential chemotherapeutic agent for VS and malignant schwannomas.

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  • (PMID = 19359162.001).
  • [ISSN] 1879-0852
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] ENG
  • [Grant] United States / NIDCD NIH HHS / DC / DC005985-04; United States / NIDCD NIH HHS / DC / R01 DC005985; United States / NIDCD NIH HHS / DC / R01 DC005985-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / OSU 03012; 0 / Protein Kinase Inhibitors; 0 / Pyrazoles; 0 / Sulfonamides; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.2 / pyruvate dehydrogenase (acetyl-transferring) kinase
  • [Other-IDs] NLM/ NIHMS103963; NLM/ PMC2692816
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89. Raftopoulos C, Abu Serieh B, Duprez T, Docquier MA, Guérit JM: Microsurgical results with large vestibular schwannomas with preservation of facial and cochlear nerve function as the primary aim. Acta Neurochir (Wien); 2005 Jul;147(7):697-706; discussion 706
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  • [Title] Microsurgical results with large vestibular schwannomas with preservation of facial and cochlear nerve function as the primary aim.
  • OBJECTIVE: To evaluate our microsurgical results in dealing with vestibular schwannomas (VS) greater than or equal to 30 mm when preservation of cranial nerve function was considered more important than total tumour removal.
  • METHODS: Sixteen consecutive cases were operated on by the same neurosurgeon according to a prospective protocol using intraoperative neuro-monitoring (IONM) based on electromyographic and brain stem auditory evoked potential recordings.
  • Facial nerve function was evaluated on the House-Brackmann Scale and cochlear nerve function on the Gardner-Robertson Scale.
  • RESULTS: Fifteen patients showed facial nerve (FN) function of House-Brackmann grade (HBG) I or II at one year postoperatively and one kept the HBG IV she had preoperatively.
  • Two patients of four maintained a cochlear nerve function of Gardner-Robertson grade (GRG) II.
  • CONCLUSION: When dealing with VS greater than or equal to 30 mm, microsurgery guided by IONM, with a rate of total or near-total tumour excision of about 75%, can retain socially acceptable facial nerve function (HBG I or II) in all cases and serviceable hearing (GRG I or II) in two cases out of four.
  • Maintaining serviceable cranial nerve function should take precedence over total tumour excision.
  • [MeSH-major] Electromyography. Evoked Potentials, Auditory, Brain Stem / physiology. Microsurgery. Monitoring, Intraoperative. Neuroma, Acoustic / surgery. Postoperative Complications / physiopathology
  • [MeSH-minor] Adult. Aged. Brain Stem / physiopathology. Child. Cochlear Nerve / physiopathology. Facial Nerve / physiopathology. Female. Follow-Up Studies. Humans. Infant. Magnetic Resonance Imaging. Male. Middle Aged. Neurologic Examination. Prospective Studies

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  • (PMID = 15900399.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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90. Liu D, Xu D, Zhang Z, Zhang Y, Zheng L: Long-term outcomes after Gamma Knife surgery for vestibular schwannomas: a 10-year experience. J Neurosurg; 2006 Dec;105 Suppl:149-53
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  • [Title] Long-term outcomes after Gamma Knife surgery for vestibular schwannomas: a 10-year experience.
  • OBJECT: The authors sought to assess the results of Gamma Knife surgery (GKS) in patients with vestibular schwannomas (VSs).
  • Nineteen patients had undergone resection of their vs. Facial nerve function was normal in 63 patients (85.1%) before GKS, and 63.5% of them had useful hearing.
  • The mean volume of the tumor at GKS was 10.79 +/- 5.52 ml (range 0.11-27.8 ml).
  • At a median follow-up period of 68.3 months (range 30-122 months), tumor shrinkage was observed in 60 patients (81.1%), and the tumor size was stable in 11 (14.8%).
  • CONCLUSIONS: Gamma Knife surgery prevents tumor growth; it achieves excellent neurological function preservation and produces few treatment-related complications.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Neurilemmoma / surgery. Radiosurgery. Vestibular Nerve. Vestibulocochlear Nerve Diseases / surgery
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Survival Analysis. Time Factors. Treatment Outcome. Tumor Burden. Young Adult

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  • (PMID = 18503349.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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91. Liard P, Guyot JP: [A series of tumors of the posterior fossa]. Rev Med Suisse; 2009 Sep 30;5(219):1925-8
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  • [Title] [A series of tumors of the posterior fossa].
  • [Transliterated title] Processus expansifs de la fosse postérieure.
  • This article presents a series of tumors of the posterior fossa.
  • In this series, 23% of vestibular schwannomas manifested by a sudden deafness, with a recovery of hearing in half of them.
  • [MeSH-major] Infratentorial Neoplasms / diagnosis. Neuroma, Acoustic / diagnosis

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  • (PMID = 19946993.001).
  • [ISSN] 1660-9379
  • [Journal-full-title] Revue médicale suisse
  • [ISO-abbreviation] Rev Med Suisse
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Switzerland
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92. Sade B, Mohr G, Dufour JJ: Vascular complications of vestibular schwannoma surgery: a comparison of the suboccipital retrosigmoid and translabyrinthine approaches. J Neurosurg; 2006 Aug;105(2):200-4
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  • [Title] Vascular complications of vestibular schwannoma surgery: a comparison of the suboccipital retrosigmoid and translabyrinthine approaches.
  • OBJECT: Vascular complications of the surgery for vestibular schwannomas (VSs) can have devastating consequences; however, there is scant literature on the systematic analysis of the different types of complications.
  • [MeSH-major] Cerebellar Diseases / etiology. Cerebral Hemorrhage / etiology. Cerebral Infarction / etiology. Craniotomy / methods. Hematoma, Epidural, Cranial / etiology. Neuroma, Acoustic / surgery. Postoperative Complications / etiology


93. Lee HK, Kim IS, Lee WS: New method of identifying the internal auditory canal as seen from the middle cranial fossa approach. Ann Otol Rhinol Laryngol; 2006 Jun;115(6):457-60
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  • OBJECTIVES: The middle cranial fossa approach allows one to remove acoustic tumors and preserve the facial nerve and hearing.

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  • (PMID = 16805378.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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94. Huang X, Zhang J, Yang H, Yu T: Use of intraoperative ultrasonography to monitor surgery for large acoustic neuromas: a pilot study. J Med Ultrason (2001); 2010 Jan;37(1):15-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Use of intraoperative ultrasonography to monitor surgery for large acoustic neuromas: a pilot study.
  • PURPOSE: Operations for large acoustic neuromas were difficult.
  • METHODS: Fifteen patients with large acoustic neuromas underwent surgical interventions.
  • RESULTS: All tumors could be identified in ultrasonic images.
  • A larger tumor volume was seen in the IOUS group but without statistical significance (29.05 ± 15.47 vs. 21.82 ± 14.78 cm(3), P = 0.3718).
  • The use of IOUS did not prolong the operation time (404.29 ± 111.18 vs. 420.00 ± 114.24 min, P = 0.7921) and did not increase the rate of intracranial infections (28.57 vs. 25.00%, P = 1.000).
  • The residual tumor detected with IOUS immediately after the operation was consistent with the data from postoperative CT/MRI scans in all cases.
  • CONCLUSION: IOUS can be used to monitor surgery in real time as a technique to assist microsurgical procedures for large acoustic neuromas with trouble.

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  • [ISSN] 1346-4523
  • [Journal-full-title] Journal of medical ultrasonics (2001)
  • [ISO-abbreviation] J Med Ultrason (2001)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Acoustic neuroma / Intraoperative ultrasonography / Microsurgery
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95. Tringali S, Marzin A, Dubreuil C, Ferber-Viart C: Bone-anchored hearing aid in unilateral inner ear deafness: electrophysiological results in patients following vestibular schwannoma removal. Acta Otolaryngol; 2008 Nov;128(11):1203-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bone-anchored hearing aid in unilateral inner ear deafness: electrophysiological results in patients following vestibular schwannoma removal.
  • This artificial acoustic difference could partly explain 'pseudo' binaural hearing.
  • [MeSH-major] Evoked Potentials, Auditory. Hearing Aids. Hearing Loss, Unilateral / rehabilitation. Neuroma, Acoustic / surgery
  • [MeSH-minor] Aged. Bone Conduction. Evoked Potentials, Auditory, Brain Stem. Female. Humans. Male. Middle Aged


96. Amit A, Achawal S, Dorward N: Pituitary macro adenoma and vestibular schwannoma: a case report of dual intracranial pathologies. Br J Neurosurg; 2008 Oct;22(5):695-6
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  • [Title] Pituitary macro adenoma and vestibular schwannoma: a case report of dual intracranial pathologies.
  • The concurrent presence of multiple primary brain tumours with different histological characteristics is very rare.
  • A case of dual intracranial benign tumours comprising pituitary adenoma and vestibular schwannoma is described.
  • The aetiology and genetic association of these pathologies is explored and the literature of multiple intracranial tumours of different cell types is reviewed.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellopontine Angle / pathology. Neoplasms, Multiple Primary / pathology. Neuroma, Acoustic / pathology. Pituitary Neoplasms / pathology

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  • (PMID = 18661423.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 4
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97. Maruyama T, Muragaki Y, Hori T: [Surgical technique for vestibular schwannoma]. No Shinkei Geka; 2006 Jul;34(7):681-93
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  • [Title] [Surgical technique for vestibular schwannoma].
  • [MeSH-major] Neuroendoscopy / methods. Neuroma, Acoustic / surgery. Neurosurgical Procedures / methods. Radiosurgery

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  • (PMID = 16841704.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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98. Liu BY, Tian YJ, Liu W, Liu SL, Qiao H, Zhang JT, Jia GJ: Intraoperative facial motor evoked potentials monitoring with transcranial electrical stimulation for preservation of facial nerve function in patients with large acoustic neuroma. Chin Med J (Engl); 2007 Feb 20;120(4):323-5
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  • [Title] Intraoperative facial motor evoked potentials monitoring with transcranial electrical stimulation for preservation of facial nerve function in patients with large acoustic neuroma.
  • The aim of this study was to investigate the effect of intraoperative facial motor evoked potentials monitoring with transcranial electrical stimulation on preservation of facial nerve function.
  • METHOD: From January to November 2005, 19 patients with large acoustic neuroma were treated using intraoperative facial motor evoked potentials monitoring with transcranial electrical stimulation (TCEMEP) for preservation of facial nerve function.
  • The relationship between the decrease of MEP amplitude after tumor removal and the postoperative function of the facial nerve was analyzed.
  • CONCLUSIONS: Intraoperative TCEMEP can be used to predict postoperative function of the facial nerve.
  • [MeSH-major] Electric Stimulation Therapy. Evoked Potentials, Motor. Facial Nerve / physiopathology. Monitoring, Intraoperative. Neuroma, Acoustic / physiopathology


99. Springborg LK, Springborg JB, Thomsen J: Hearing preservation after classical translabyrinthine removal of a vestibular schwannoma: case report and literature review. J Laryngol Otol; 2007 Jan;121(1):76-9
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  • [Title] Hearing preservation after classical translabyrinthine removal of a vestibular schwannoma: case report and literature review.
  • The translabyrinthine approach is one of the favoured access routes for removal of vestibular schwannomas; however, total hearing loss in the operated ear is a predictable consequence.
  • Possible explanations for the hearing preservation are discussed, as well as the feasibility of a modified translabyrinthine approach in attempting preservation of hearing following vestibular schwannoma surgery.
  • [MeSH-major] Ear, Inner / surgery. Hearing Loss / prevention & control. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods

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  • (PMID = 17052366.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 30
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100. Huy PT, Sauvaget E: Unilateral rhinorrhea after translabyrinthine surgery due to parasympathetic hypersensitive syndrome: differentiation from cerebrospinal fluid leakage. Otol Neurotol; 2010 Sep;31(7):1160-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Unilateral rhinorrhea after translabyrinthine surgery for vestibular or facial schwannoma usually suggests cerebrospinal fluid (CSF) leakage and requires specific measures, including revision surgery.
  • PATIENTS AND INTERVENTION: For 1 case of intratemporal facial schwannoma and 2 cases of vestibular schwannoma, surgery was by a translabyrinthine approach with sacrifice of the facial nerve and hypoglossofacial anastomosis in the first case.
  • CONCLUSION: With unilateral rhinorrhea after translabyrinthine surgery for vestibular or facial schwannoma, concomitant symptoms such as lacrimation or hypersialorrhea may not be explained by CSF leakage through the eustachian tube.
  • [MeSH-minor] Administration, Intranasal. Adult. Anastomosis, Surgical. Cholinergic Antagonists / administration & dosage. Cholinergic Antagonists / therapeutic use. Cranial Nerve Neoplasms / surgery. Diagnosis, Differential. Facial Nerve / surgery. Facial Nerve Diseases / surgery. Humans. Hypoglossal Nerve / surgery. Male. Middle Aged. Neurilemmoma / surgery. Neuroma, Acoustic / surgery

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  • (PMID = 20657327.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cholinergic Antagonists
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