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1. Agrawal A, Pandit L, Bhandary S, Makannavar JH, Srikrishna U: Glossopharyngeal schwannoma: diagnostic and therapeutic aspects. Singapore Med J; 2007 Jul;48(7):e181-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Glossopharyngeal schwannoma: diagnostic and therapeutic aspects.
  • Among posterior fossa tumours, schwannomas arising from glossopharyngeal nerves are extremely rare, and only 39 cases of glossopharyngeal schwannomas have been described.
  • The clinical and imaging features of glossopharyngeal schwannomas closely resemble that of acoustic schwannomas.
  • Despite its accuracy, magnetic resonance imaging is not diagnostic of a ninth nerve schwannoma.
  • This is because the schwannoma may be primarily localised to the cerebellopontine angle and may not cause enlargement of the jugular foramen.
  • The diagnosis is possible only at surgery, once attachment to the ninth cranial nerve is seen.
  • We review the relevant literature and discuss the clinical presentation, radiological features and surgical findings in a 52-year-old woman with glossopharyngeal schwannoma.
  • [MeSH-major] Glossopharyngeal Nerve Diseases / diagnosis. Glossopharyngeal Nerve Diseases / surgery. Neurilemmoma / diagnosis. Neurilemmoma / surgery

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  • (PMID = 17609810.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Singapore
  • [Number-of-references] 27
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2. Thariat J, Li G, Angellier G, Marchal S, Palamini G, Rucka G, Bénézery K, Castelli J, Trimaud R, Mammar H, Marcie S, Gérard JP, Bondiau PY: [Current indications and ongoing clinical trials with CyberKnife stereotactic radiotherapy in France in 2009]. Bull Cancer; 2009 Sep;96(9):853-64
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  • [Transliterated title] Indications du CyberKnife et essais cliniques en cours en 2009.
  • It is advantageous for radioresistant tumors, re-irradiating lesions, boosting small volumes and treating tumors that move with respiration.
  • These expert Cyberknife centres follow quality assurance programs and work together with the "Haute Autorité de santé" and the French National Cancer Institute (INCa) to promote clinical developments.
  • The CyberKnife has been used to treat intracranial lesions including (but not limited to) meningiomas, acoustic schwannomas, brain oligometastases, as well as skull base tumors like chordomas, or para- or intraspinal tumors, and extracranial tumors such as lung cancers.
  • Currently, extracranial stereotactic radiotherapy is particularly attractive for tumors moving with respiration and is being evaluated in liver, prostate and re-irradiation including head and neck tumors.
  • [MeSH-minor] Brain Neoplasms / surgery. Breast Neoplasms / surgery. Female. France. Humans. Liver Neoplasms / secondary. Liver Neoplasms / surgery. Lung Neoplasms / secondary. Lung Neoplasms / surgery. Male. Otorhinolaryngologic Neoplasms / surgery. Prostatic Neoplasms / surgery. Soft Tissue Neoplasms / surgery

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  • (PMID = 19736172.001).
  • [ISSN] 1769-6917
  • [Journal-full-title] Bulletin du cancer
  • [ISO-abbreviation] Bull Cancer
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 35
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3. Huang CF, Tu HT, Lo HK, Wang KL, Liu WS: Radiosurgery for vestibular schwannomas. J Chin Med Assoc; 2005 Jul;68(7):315-20
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  • [Title] Radiosurgery for vestibular schwannomas.
  • We report our experience with radiosurgery for tumor control and the complications of unilateral vestibular schwannomas.
  • METHODS: We reviewed our early experience regarding clinical presentation, management and outcomes in 45 patients with acoustic schwannomas who underwent gamma knife stereotactic radiosurgery.
  • Median tumor volume was 4.5 mL (range, 0.5-30.0), and median radiotherapy dose was 11.5 Gy (range, 10.5-14.0 Gy).
  • RESULTS: Tumor control was achieved in 43 patients (95.6%).
  • Reduction in tumor size was shown in 15 patients (33.3%).
  • No patients had delayed facial palsy or lower cranial nerve dysfunction, but one had delayed trigeminal sensory loss.
  • CONCLUSION: Radiosurgery achieved a high tumor control rate and a relatively low post-radiosurgical complication rate for acoustic neuromas.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery

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  • (PMID = 16038371.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China (Republic : 1949- )
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4. Coca Pelaz A, Rodrigo JP, Llorente JL, Gómez JR, Suárez C: [Unusual clinical presentations of vestibular schwannomas]. Acta Otorrinolaringol Esp; 2008 Apr;59(4):187-9
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  • [Title] [Unusual clinical presentations of vestibular schwannomas].
  • [Transliterated title] Formas clínicas inusuales de presentación de los neurinomas del acústico.
  • The aim of this study is evaluate the unusual ways of initial presentation of the vestibular schwannomas.
  • We performed a retrospective study of the patients who underwent resection of acoustic neuromas on our service, including for analysis only the cases which initial symptom was not the hearing loss.
  • Tumor size, localization, clinical presentation, and age of the patients were considered.
  • A significant group of patients did not present with the otological symptoms classically associated with vestibular schwannoma.
  • [MeSH-major] Cerebellopontine Angle / pathology. Hearing Loss / etiology. Neuroma, Acoustic / complications. Neuroma, Acoustic / pathology

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  • (PMID = 18447978.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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5. Archibald DJ, Neff BA, Voss SG, Splinter PL, Driscoll CL, Link MJ, Dong H, Kwon ED: B7-H1 expression in vestibular schwannomas. Otol Neurotol; 2010 Aug;31(6):991-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] B7-H1 expression in vestibular schwannomas.
  • HYPOTHESIS: B7-H1 is expressed in vestibular schwannomas.
  • BACKGROUND: Little is known about how benign human vestibular schwannomas interact with antibody-mediated or cell-mediated immunity.
  • We report on the aberrant expression of a novel T-cell coregulatory molecule, B7 homolog 1 (B7-H1), in vestibular schwannomas and discuss the implications of B7-H1 expression and tumor aggressiveness and a potential regulator of B7-H1 expression.
  • METHODS: Immunohistochemical staining for B7-H1, CD8+, CD3+, and CD4+ lymphocytes were performed on 48 fresh-frozen vestibular schwannoma tissue specimens.
  • A clinical review of patient presenting symptoms and tumor characteristics was performed.
  • Real-time polymerase chain reaction was used to determine if there was differential expression of B7-H1 messenger RNA and microRNA-513, a known regulator of B7-H1, in several strongly positive and negative B7-H1 vestibular schwannomas.
  • RESULTS: Nine (19%) of 48 tumors were negative, 23 (48%) tumors were 1+ mildly positive (<20% section area), and 16 (33%) stained 2+ strongly positive (>or=20% section area) for B7-H1.
  • The average number of CD8 cells per high-power field was 2.1 for positive-staining tumors and 1.0 for negative tumors (p = 0.16).
  • Failure of tumor control with stereotactic radiation (p = 0.029) was significantly greater in the strongly positive B7-H1 tumors.
  • Real-time polymerase chain reaction did not show significant differential expression of microRNA-513 (p = 0.62) or B7-H1 messenger RNA (p = 0.35) between the tumors showing strong and negative immunohistochemical staining for B7-H1 protein.
  • CONCLUSION: Vestibular schwannoma tumors express B7-H1, which has been associated with immune tolerance and adverse disease characteristics in several malignancies.
  • Growing tumors that were surgically removed after failed stereotactic radiation therapy were significantly more likely to strongly express B7-H1 protein, which lends some credibility to the hypothesis that immuno-evasion may play some role in their continued growth.
  • Although clinical trends were seen, greater statistical power is required to evaluate whether B7-H1 expression correlates with more aggressive tumor growth or poorer hearing class.
  • B7-H1 seems to be expressed in equal amounts at the RNA level in all vestibular schwannoma tumors that suggests that differential protein expression is occurring at the posttranscriptional level.
  • However, microRNA-513 does not regulate B7-H1 protein expression in these tumors.

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  • (PMID = 20601920.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA134345-03; United States / NCI NIH HHS / CA / R01 CA134345; United States / NCI NIH HHS / CA / R01 CA134345-03
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD274; 0 / CD274 protein, human; 0 / RNA, Messenger
  • [Other-IDs] NLM/ NIHMS242934; NLM/ PMC4810681
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6. Propp JM, McCarthy BJ, Davis FG, Preston-Martin S: Descriptive epidemiology of vestibular schwannomas. Neuro Oncol; 2006 Jan;8(1):1-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Descriptive epidemiology of vestibular schwannomas.
  • Vestibular schwannomas, commonly termed acoustic neuromas, arise from the vestibular branch of the eighth cranial nerve (acoustic nerve) and are benign, slow-growing brain tumors that negatively impact patient quality of life.
  • They are thought to account for the majority of intracranial nerve sheath tumors.
  • To describe incidence rate patterns and trends of primary nerve sheath tumors of the brain/CNS and the subset of vestibular schwannomas in two population-based incidence registries, data were obtained from 11 Central Brain Tumor Registry of the United States (CBTRUS) collaborating state registries and the Los Angeles County Cancer Surveillance Program (LACCSP) (1975-1998).
  • Multiplicative Poisson regression models were used to compare trends in primary nerve sheath tumors of the brain/CNS overall and in subgroups, including vestibular schwannomas, controlling for age, gender, race, microscopic confirmation, and region.
  • The overall incidence of primary nerve sheath tumors of the brain/CNS was 1.1 per 100,000 person-years (CBTRUS, 1995-1999 and LACCSP, 1995-1998).
  • The incidence of vestibular schwannomas was similar for both data sets: 0.6 per 100,000 person-years (CBTRUS, 1995-1999) and 0.8 per 100,000 person-years (LACCSP, 1995-1998).
  • Moreover, the incidence of primary nerve sheath tumors of the brain/CNS overall (CBTRUS, 1985-1999 and LACCSP, 1975-1998) and of vestibular schwannomas (CBTRUS, 1992-1999 and LACCSP, 1992-1998) increased over time.
  • However, the incidence of benign schwannomas in sites other than the acoustic nerve either decreased (CBTRUS, 1992-1999) or experienced no significant change (LACCSP, 1992-1998).
  • [MeSH-major] Neuroma, Acoustic / epidemiology. Registries

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  • (PMID = 16443943.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1871924
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7. Sahu RN, Behari S, Agarwal VK, Giri PJ, Jain VK: Taste dysfunction in vestibular schwannomas. Neurol India; 2008 Jan-Mar;56(1):42-6
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  • [Title] Taste dysfunction in vestibular schwannomas.
  • BACKGROUND: Gustatory dysfunction associated with vestibular schwannomas (VS) is a poorly represented clinical presentation.
  • Preoperatively, taste disturbance was found in 29 (37.2%) giant, 28 (45.9%) large and one (33.3%) medium-sized tumors, respectively.
  • Among patients with anatomically preserved facial nerve, postoperative taste disturbances were found in 55 (42.3%) patients whereas nine (6.9%) patients reported improvement in taste sensations.
  • CONCLUSIONS: Taste dysfunction is common following vestibular schwannoma surgery.
  • Taste dysfunction should be included in the facial nerve functional grading system while assessing outcome.
  • [MeSH-major] Neuroma, Acoustic / complications. Taste Disorders / etiology

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  • (PMID = 18310836.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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8. Piedra MP, Scheithauer BW, Driscoll CL, Link MJ: Primary Melanocytic Tumor of the Cerebellopontine Angle Mimicking a Vestibular Schwannoma. Neurosurgery; 2006 Jul 01;59(1):E206

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary Melanocytic Tumor of the Cerebellopontine Angle Mimicking a Vestibular Schwannoma.

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  • (PMID = 28180621.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Abram S, Rosenblatt P, Holcomb S: Stereotactic radiation techniques in the treatment of acoustic schwannomas. 2007. Neurosurg Clin N Am; 2008 Apr;19(2):367-77, vii-viii
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Stereotactic radiation techniques in the treatment of acoustic schwannomas. 2007.
  • The goals of the treatment of acoustic schwannomas are prohibiting tumor growth and alleviation of symptoms caused by damage to local structures.
  • These symptoms-tinnitus, ataxia, and hearing loss-secondary to eighth nerve dysfunction, as well as symptoms arising from damage to adjacent structures such as the facial nerve, trigeminal nerve, or pons, can be caused by tumor growth or treatment.
  • Determination of optimal therapy must also take into account an understanding of the natural history of the disease, because acoustic schwannomas are slow-growing benign tumors that when left untreated, usually enlarge over time and cause problems.
  • [MeSH-major] Neuroma, Acoustic / history. Stereotaxic Techniques / history

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  • (PMID = 18534345.001).
  • [ISSN] 1558-1349
  • [Journal-full-title] Neurosurgery clinics of North America
  • [ISO-abbreviation] Neurosurg. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Biography; Classical Article; Historical Article; Journal Article
  • [Publication-country] United States
  • [Personal-name-as-subject] Abram S; Rosenblatt P; Holcomb S
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10. Abram S, Rosenblatt P, Holcomb S: Stereotactic radiation techniques in the treatment of acoustic schwannomas. Otolaryngol Clin North Am; 2007 Jun;40(3):571-88, ix
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Stereotactic radiation techniques in the treatment of acoustic schwannomas.
  • The goals of the treatment of acoustic schwannomas are prohibiting tumor growth and alleviation of symptoms caused by damage to local structures.
  • These symptoms-tinnitus, ataxia, and hearing loss--secondary to eighth nerve dysfunction, as well as symptoms arising from damage to adjacent structures such as the facial nerve, trigeminal nerve, or pons, can be caused by tumor growth or treatment.
  • Determination of optimal therapy must also take into account an understanding of the natural history of the disease, because acoustic schwannomas are slow-growing benign tumors that when left untreated, usually enlarge over time and cause problems.
  • [MeSH-major] Ear Neoplasms / pathology. Ear Neoplasms / radiotherapy. Neuroma, Acoustic / pathology. Neuroma, Acoustic / radiotherapy. Radiosurgery / instrumentation. Stereotaxic Techniques
  • [MeSH-minor] Algorithms. Dose Fractionation. Follow-Up Studies. Humans. Hydrocephalus / epidemiology. Magnetic Resonance Imaging. Neoplasm Invasiveness. Neurofibromatosis 2 / epidemiology. Tinnitus / epidemiology. Vertigo / epidemiology

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  • (PMID = 17544696.001).
  • [ISSN] 0030-6665
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 31
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11. Myrseth E, Møller P, Wentzel-Larsen T, Goplen F, Lund-Johansen M: Untreated Vestibular Schwannoma: Vertigo is a Powerful Predictor for Health-Related Quality of Life. Neurosurgery; 2006 Jul 01;59(1):67-76

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Untreated Vestibular Schwannoma: Vertigo is a Powerful Predictor for Health-Related Quality of Life.

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  • (PMID = 28180608.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Hasegawa T, Kida Y, Yoshimoto M, Koike J, Goto K: TABLEEvaluation of Tumor Expansion after Stereotactic Radiosurgery in Patients Harboring Vestibular Schwannomas. Neurosurgery; 2006 Jun 01;58(6):1119-1128

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] TABLEEvaluation of Tumor Expansion after Stereotactic Radiosurgery in Patients Harboring Vestibular Schwannomas.

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  • (PMID = 28173267.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Marshall AH, Owen VM, Nikolopoulos TP, O'Donoghue GM: Acoustic schwannomas: awareness of radiologic error will reduce unnecessary treatment. Otol Neurotol; 2005 May;26(3):512-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acoustic schwannomas: awareness of radiologic error will reduce unnecessary treatment.
  • OBJECTIVE: To measure the intra- and interobserver error in size estimation of acoustic schwannomas from magnetic resonance imaging (MRI) scans by experienced radiologists to determine whether small amounts of tumor growth that may affect management (2 mm) could be reliably measured in clinical practice.
  • DESIGN: Duplicated, blinded size estimation of acoustic neuromas (according to American Academy of Otolaryngology-Head and Neck Surgery guidelines, 1995) from MRI scans of patients with acoustic neuromas.
  • PARTICIPANTS: Four radiologists (including 2 dedicated neuroradiologists) measuring positive MRI scans of 26 patients with an acoustic neuroma.
  • MAIN OUTCOME MEASURE: Intraradiologist and inter-radiologist repeatability coefficients in millimeters for the maximal tumor diameter in the anteroposterior (AP) axis, medial-longitudinal (ML) axis, and the square-root of the product of these two measurements.
  • CONCLUSION: The study indicates that, in routine clinical practice, differences in tumor size of the order of 2 mm cannot be reliably measured, even by the same radiologist.
  • Thus, reported growth of acoustic tumors should be interpreted with caution, especially if this is the criterion for recommending treatment.
  • [MeSH-major] Magnetic Resonance Imaging. Neuroma, Acoustic / diagnosis

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  • (PMID = 15891658.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Smith MC, Ryken TC, Buatti JM: Radiotoxicity after conformal radiation therapy for benign intracranial tumors. Neurosurg Clin N Am; 2006 Apr;17(2):169-80, vii
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiotoxicity after conformal radiation therapy for benign intracranial tumors.
  • Acoustic schwannomas, skull base meningiomas, and pituitary adenomas are benign intracranial tumors frequently managed with radiotherapy.
  • Control rates after treatment for each of these tumors are generally high, and toxicity from treatment is relatively low.
  • Side effect profiles depend on the tumor location, the volume treated, the dose delivered, and the presence of nearby critical structures.
  • This article reviews radiotoxicity after conformal radiation therapy for acoustic schwannomas, skull base meningiomas, and pituitary adenomas.
  • [MeSH-major] Brain Neoplasms / radiotherapy. Neuroma, Acoustic / radiotherapy. Radiotherapy, Conformal / adverse effects

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  • (PMID = 16793508.001).
  • [ISSN] 1042-3680
  • [Journal-full-title] Neurosurgery clinics of North America
  • [ISO-abbreviation] Neurosurg. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 27
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15. Siddiqui MA, Leslie T, Scott C, Mackenzie J: Eyelid schwannoma in a male adult. Clin Exp Ophthalmol; 2005 Aug;33(4):412-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eyelid schwannoma in a male adult.
  • Schwannomas (neurilemmomas) are benign tumours of peripheral nerves arising from Schwann cells.
  • These tumours along with neurofibromas form the two most common primary peripheral nerve tumours.
  • Solitary lesions can occur sporadically in the general population but multiple neurofibromas are distinctive feature of neurofibromatosis type 1 and bilateral acoustic schwannomas are a feature of neurofibromatosis type 2.
  • Schwannomas of ophthalmic interest are rare although they have been reported in relation to the orbit, and infrequently uveal tract and conjunctiva.
  • Isolated eyelid schwannomas appear infrequent; only four cases in adults and one in a child in the published literature have been found.
  • Herein, a case of eyelid schwannoma in a 53-year-old man is described.
  • [MeSH-major] Eyelid Neoplasms / pathology. Neurilemmoma / pathology

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  • (PMID = 16033357.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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16. Sugo N, Yokota K, Nemoto M, Hatori T, Kano T, Goto S, Seiki Y: Accelerated growth of an orbital schwannoma during pregnancy. J Neuroophthalmol; 2007 Mar;27(1):45-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Accelerated growth of an orbital schwannoma during pregnancy.
  • Removed early after delivery by a transcranial approach, the tumor was histologically diagnosed as a richly vascularized cystic schwannoma containing red blood cell components.
  • The accelerated tumor growth was attributed to intratumoral hemorrhage.
  • Although acoustic schwannomas have been reported to enlarge during pregnancy, this phenomenon has only been described once for orbital schwannomas.
  • Because this type of tumor may enlarge during pregnancy and threaten visual function, surgery should not be delayed.
  • [MeSH-major] Neurilemmoma / pathology. Orbital Neoplasms / pathology. Pregnancy Complications, Neoplastic
  • [MeSH-minor] Adult. Diagnosis, Differential. Disease Progression. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Microsurgery. Ophthalmologic Surgical Procedures / methods. Pregnancy. Tomography, X-Ray Computed. Visual Acuity

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  • (PMID = 17414873.001).
  • [ISSN] 1070-8022
  • [Journal-full-title] Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
  • [ISO-abbreviation] J Neuroophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Tlachacova D, Schmitt M, Novotny J Jr, Novotny J, Majali M, Liscak R: A comparison of the gamma knife model C and the Automatic Positioning System with Leksell model B. J Neurosurg; 2005 Jan;102(s_supplement):25-28

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Data were analyzed in patients in whom the following diagnoses had been made: vestibular schwannoma, pituitary adenoma, meningioma, solitary metastasis, and other benign and malignant solitary tumors.
  • CONCLUSIONS: With the C model there was a better conformity for most treated targets, such as vestibular schwannomas (p = 0.005) and meningiomas (p = 0.015).

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  • (PMID = 28306471.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; conformity index / extracranial exposure / staff exposure / stereotactic radiosurgery
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18. Chung WY, Liu KD, Shiau CY, Wu HM, Wang LW, Guo WY, Ming-Tak Ho D, Hung-Chi Pan D: Gamma knife surgery for vestibular schwannoma: 10-year experience of 195 cases. J Neurosurg; 2005 Jan;102(s_supplement):87-97

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gamma knife surgery for vestibular schwannoma: 10-year experience of 195 cases.
  • OBJECT: The authors conducted a study to determine the optimal radiation dose for vestibular schwannoma (VS) and to examine the histopathology in cases of treatment failure for better understanding of the effects of irradiation.
  • Seventy-two patients (37%) had undergone partial or total excision of their tumor prior to gamma knife surgery (GKS).
  • The mean tumor volume was 4.1 cm<sup>3</sup> (range 0.04-23.1 cm<sup>3</sup>).
  • Multiisocenter dose planning placed a prescription dose of 11 to 18.2 Gy on the 50 to 94% isodose located at the tumor margin.
  • At the latest MR imaging assessment decreased or stable tumor volume was demonstrated in 93.6% of the patients.
  • Uncontrolled tumor swelling was noted in five patients at 3.5, 17, 24, 33, and 62 months after GKS, respectively.
  • Histopathological examination of specimens in three cases (one at 62 months after GKS) revealed a long-lasting radiation effect on vessels inside the tumor.
  • A margin 12-Gy dose with homogeneous distribution is effective in preventing tumor progression, while posing no serious threat to normal cranial nerve function.

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  • (PMID = 28306447.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; gamma knife surgery / stereotaxy / vestibular schwannoma
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19. Lunsford LD, Niranjan A, Flickinger JC, Maitz A, Kondziolka D: Radiosurgery of vestibular schwannomas: summary of experience in 829 cases. J Neurosurg; 2005 Jan;102(s_supplement):195-199

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiosurgery of vestibular schwannomas: summary of experience in 829 cases.
  • OBJECT: Management options for vestibular schwannomas (VSs) have greatly expanded since the introduction of stereotactic radiosurgery.
  • Optimal outcomes reflect long-term tumor control, preservation of cranial nerve function, and retention of quality of life.
  • The average tumor volume was 2.5 cm<sup>3</sup>.
  • The median margin dose to the tumor was 13 Gy (range 10-20 Gy).
  • Unchanged hearing preservation was possible in 50 to 77% of patients (up to 90% in those with intracanalicular tumors).
  • Trigeminal symptoms were detected in less than 3% of patients whose tumors reached the level of the trigeminal nerve.
  • Tumor control rates at 10 years were 97% (no additional treatment needed).
  • Gamma knife surgery provides a low risk, minimally invasive treatment option for patients with newly diagnosed or residual vs. Cranial nerve preservation and quality of life maintenance are possible in long-term follow up.

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  • (PMID = 28306432.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; gamma knife surgery / radiosurgery / vestibular schwannoma
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20. Wowra B, Muacevic A, Jess-Hempen A, Hempel JM, Müller-Schunk S, Tonn JC: Outpatient gamma knife surgery for vestibular schwannoma: definition of the therapeutic profile based on a 10-year experience. J Neurosurg; 2005 Jan;102(s_supplement):114-118

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outpatient gamma knife surgery for vestibular schwannoma: definition of the therapeutic profile based on a 10-year experience.
  • OBJECT: The purpose of the study was to define the therapeutic profile of outpatient gamma knife surgery (GKS) for vestibular schwannoma (VS) by using sequential tumor volumetry to quantify changes following treatment.
  • The actuarial 6-year tumor control rate after a single GKS treatment was 95%.
  • Tumor swelling was observed in 43 patients (38.7%).
  • Recurrence was significantly associated with NF2 (p < 0.003) and the reduced dose (p < 0.03) delivered to these tumors.
  • The incidence of facial nerve neuropathy was mainly determined by surgery prior to GKS (p < 0.0001).
  • Facial nerve radiation toxicity was mild and transient.
  • No permanent facial nerve toxicity was observed.
  • The risk of hearing loss was correlated with age and transient tumor swelling (p < 0.05) but not with dose parameters or NF2.

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  • (PMID = 28306422.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; gamma knife surgery / tumor volumetry / vestibular schwannoma
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21. van Eck AT, Horstmann GA: Increased preservation of functional hearing after gamma knife surgery for vestibular schwannoma. J Neurosurg; 2005 Jan;102(s_supplement):204-206

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Increased preservation of functional hearing after gamma knife surgery for vestibular schwannoma.
  • OBJECT: Gamma knife surgery (GKS) for vestibular schwannoma is still associated with an additional hearing loss of approximately 30%.
  • The mean tumor volume was 2.28 cm<sup>3</sup>.
  • After a mean follow-up duration of 22 months, the magnetic resonance imaging-based tumor control rate was 87%.
  • One patient suffered transient facial nerve impairment.
  • CONCLUSIONS: Reducing the maximum dose to 20 Gy seems to be an effective treatment, which probably increases preservation of functional hearing without sacrificing the high tumor control rates achieved in radiosurgery.
  • Post-radiosurgery tumor swelling occurred in 25% of the cases and was not correlated with hearing deterioration.

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  • (PMID = 28306452.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; acoustic neurinoma / gamma knife surgery / hearing preservation / tumor swelling / vestibular schwannoma
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22. Willekens BM, Rooker S, Dua G, Appel B, Martin JJ, Crols R, De Deyn PP: Central nervous system metastases of pulmonary adenocarcinoma mimicking neurofibromatosis type 2. Acta Neurol Belg; 2006 Jun;106(2):87-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Neuroimaging revealed bilateral VIIIth cranial nerve masses and multiple cerebral and spinal cord lesions that were interpreted as being acoustic schwannomas and multiple meningeomas.

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  • (PMID = 16898259.001).
  • [ISSN] 0300-9009
  • [Journal-full-title] Acta neurologica Belgica
  • [ISO-abbreviation] Acta Neurol Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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23. Yokoo H, Oishi T, Isoda K, Nakazato Y, Toyokuni S: Oxidative stress is related to the formation of Antoni B patterns and eosinophilic hyaline droplets in schwannomas. Neuropathology; 2007 Jun;27(3):237-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oxidative stress is related to the formation of Antoni B patterns and eosinophilic hyaline droplets in schwannomas.
  • Schwannomas, particularly of vestibular origin, often accompany degenerative hypocellular areas known as Antoni B patterns; however, the detailed mechanism is uncertain.
  • Eosinophilic hyaline droplets (EHD), the substantial nature of which are autophagic vacuoles, preferentially appear in acoustic schwannomas and distribute around areas of Antoni B.
  • We investigated their common background using schwannomas with (15 cases) or without (10 cases) EHD, and demonstrated that EHD showed selective immunoreactivity with an anti-nitrotyrosine antibody, suggesting the overproduction of nitric oxide in this condition.
  • Antibodies to cleaved caspase-3 and single strand DNA, indicators of apoptosis, did not label tumors cells in Antoni B areas as well as EHD-bearing cells.
  • The morphology and the mitotically static state of EHD-laden cells are phenotypically similar to autophagic cell death; however, autophagy in normal cells is a cell survival strategy against starvation, so the possibility remains that EHD are formed in that context.
  • In either case, schwannomas may show a characteristic autophagic change by an endogenous mechanism.
  • Tumor growth in a narrow intracranial space and resultant ischemia by self-oppression were postulated to be an initial event, because ischemia-reperfusion injury is a major source of reactive oxygen species and ischemia is also a potent trigger of autophagy as well as of tissue degeneration.
  • [MeSH-major] Hyalin / ultrastructure. Inclusion Bodies / ultrastructure. Neurilemmoma / pathology. Neurilemmoma / physiopathology. Oxidative Stress / physiology

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  • (PMID = 17645238.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Aldehydes; 0 / Apolipoproteins D; 29343-52-0 / 4-hydroxy-2-nonenal; 3604-79-3 / 3-nitrotyrosine; 42HK56048U / Tyrosine; 88847-89-6 / 8-oxo-7-hydrodeoxyguanosine; EC 1.14.13.39 / Nitric Oxide Synthase Type II; EC 3.4.22.- / Caspase 3; G9481N71RO / Deoxyguanosine
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24. Lutterbach J, Pagenstecher A, Spreer J, Hetzel A, Velthoven Vv, Nikkhah G, Frommhold H, Volk B, Schumacher M, Lücking C, Zentner J, Ostertag C: The brain tumor board: lessons to be learned from an interdisciplinary conference. Onkologie; 2005 Jan;28(1):22-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The brain tumor board: lessons to be learned from an interdisciplinary conference.
  • BACKGROUND: The aim of this study is to analyze the work of the interdisciplinary Brain Tumor Board (BTB) which was established at Freiburg University Hospital in 1998.
  • This group was composed of 4 subgroups: 28% benign skull base tumors (19% meningiomas, 4% pituitary adenomas, 3% acoustic schwannomas, 2% others), 24% primary brain tumors of glial origin (8% glioblastomas, 12% gliomas other than glioblastomas, 5% oligoastrocytomas or oligodendrogliomas), 19% brain metastases, and 8% other brain or skull base tumors.
  • CONCLUSION: Interdisciplinary care seems to be particularly necessary in patients with benign skull base tumors, gliomas and brain metastases.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / therapy. Clinical Trials Data Monitoring Committees / statistics & numerical data. Decision Support Systems, Clinical / statistics & numerical data. Outcome Assessment (Health Care). Patient Care Team / statistics & numerical data. Quality Assurance, Health Care / statistics & numerical data

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  • (PMID = 15616378.001).
  • [ISSN] 0378-584X
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Switzerland
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25. Behari S, Tyagi I, Banerji D, Kumar V, Jaiswal AK, Phadke RV, Jain VK: Postauricular, transpetrous, presigmoid approach for extensive skull base tumors in the petroclival region: the successes and the travails. Acta Neurochir (Wien); 2010 Oct;152(10):1633-45

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Postauricular, transpetrous, presigmoid approach for extensive skull base tumors in the petroclival region: the successes and the travails.
  • METHODS: The lesions (n = 14) included petroclival meningiomas [(n = 5), including three recurrent lesions], dumbbell lower cranial nerve schwannomas (n = 2), giant acoustic schwannomas (n = 2), recurrent giant trigeminal nerve schwannoma (n = 1), glomus jugulare (n = 3), and recurrent petrous aneurysmal bone cyst (n = 1).
  • Small tumor remnants were left attached to the brainstem (n = 3, petroclival meningioma), carotid canal and cavernous sinus (n = 1, glomus jugulare), and sigmoid sinus-jugular bulb (n = 1, recurrent trigeminal schwannoma).
  • Two patients with recurrent giant petroclival meningiomas died: one with lower cranial nerve paresis due to aspiration pneumonitis and the other with cerebrospinal fluid otorrhoea and secondary meningitis.
  • CONCLUSIONS: The approach facilitates direct tumor decompression and its retraction away from the brainstem without initially encountering the intracisternal cranial nerves and neuraxis.
  • It provides multiple corridors for excising extensive posterior fossa tumors.
  • [MeSH-minor] Glomus Jugulare Tumor / diagnosis. Glomus Jugulare Tumor / pathology. Glomus Jugulare Tumor / surgery. Humans. Meningeal Neoplasms / diagnosis. Meningeal Neoplasms / pathology. Meningeal Neoplasms / surgery. Meningioma / diagnosis. Meningioma / pathology. Meningioma / surgery. Neurilemmoma / diagnosis. Neurilemmoma / pathology. Neurilemmoma / surgery. Retrospective Studies

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  • (PMID = 20556624.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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26. Inoue HK: Low-dose radiosurgery for large vestibular schwannomas: long-term results of functional preservation. J Neurosurg; 2005 Jan;102(s_supplement):111-113

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Low-dose radiosurgery for large vestibular schwannomas: long-term results of functional preservation.
  • OBJECT: The author conducted a study to assess the long-term results obtained in patients who underwent GKS for large vestibular schwannomas (> cochlear nerve functions were evaluated.
  • METHODS: Twenty consecutive large tumors in 18 patients (including two cases of neurofibromatosus Type 2 [NF2]) were followed for more than 6 years.
  • There were eight tumors that were more than 4 cm in maximum diameter.
  • Microsurgery had already been performed prior to GKS in 11 patients (nine recurrent and two residual tumors).
  • Fourteen of 15 tumors were stable or decreased in size.
  • Facial nerve function was preserved in all patients and hearing preserved in four of five patients with cochlear nerve function prior to radiosurgery.
  • CONCLUSIONS: Gamma knife surgery seems to have a place in the low-dose treatment of selected large vestibular schwannoma in patients with a reasonable chance of retaining facial function and pretreatment hearing level.

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  • (PMID = 28306427.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; facial function / gamma knife surgery / outcome / vestibular schwannoma
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27. Chang LS, Welling DB: Molecular biology of vestibular schwannomas. Methods Mol Biol; 2009;493:163-77
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular biology of vestibular schwannomas.
  • Recent advances in molecular biology have led to a better understanding of the etiology of vestibular schwannomas.
  • The underlying purpose of vestibular schwannoma research is the development of new treatment options; however, such options have not yet been established.
  • A fundamental understanding of the underlying molecular events leading to tumor formation began when mutations in the neurofibromatosis type 2 (NF2) tumor suppressor gene were identified in vestibular schwannomas.
  • The clinical characteristics of vestibular schwannomas and neurofibromatosis type 2 (NF2) syndromes have both been related to alterations in the NF2 gene.
  • When utilized with clinical screening, such as magnetic resonance imaging (MRI), conventional audiometry, and auditory brainstem response (ABR), the early detection of NF2 can be made, which consequently makes a significant difference in the ability to successfully treat vestibular schwannomas.
  • Nf2-transgenic and knockout mice as well as vestibular schwannoma xenograft models are now ready for novel therapeutic testing.
  • [MeSH-major] Mutation. Neurofibromin 2 / genetics. Neuroma, Acoustic / genetics
  • [MeSH-minor] Animals. DNA Mutational Analysis. Genetic Predisposition to Disease. Humans. Magnetic Resonance Imaging. Mice. Mice, Knockout. Mice, SCID. Mice, Transgenic. Neurofibromatosis 2 / genetics. Neurofibromatosis 2 / pathology

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  • (PMID = 18839347.001).
  • [ISSN] 1064-3745
  • [Journal-full-title] Methods in molecular biology (Clifton, N.J.)
  • [ISO-abbreviation] Methods Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neurofibromin 2
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28. Mackle T, Rawluk D, Walsh RM: Atypical clinical presentations of vestibular schwannomas. Otol Neurotol; 2007 Jun;28(4):526-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical clinical presentations of vestibular schwannomas.
  • A significant number of patients with vestibular schwannomas present atypically, with none of the classical symptoms of unilateral sensorineural hearing loss, tinnitus, and/or dysequilibrium.
  • STUDY DESIGN: The clinical data of all patients who presented to the vestibular schwannoma clinic at Beaumont Hospital over the past 12 years was prospectively recorded in a computerized database.
  • CONCLUSION: A significant subgroup, 3.7% in our study, did not present with the audiovestibular symptoms classically associated with vestibular schwannoma.
  • [MeSH-major] Neuroma, Acoustic / diagnosis

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  • (PMID = 17414179.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Tan M, Myrie OA, Lin FR, Niparko JK, Minor LB, Tamargo RJ, Francis HW: Trends in the management of vestibular schwannomas at Johns Hopkins 1997-2007. Laryngoscope; 2010 Jan;120(1):144-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Trends in the management of vestibular schwannomas at Johns Hopkins 1997-2007.
  • OBJECTIVES/HYPOTHESIS: To assess trends in the management of unilateral vestibular schwannomas over an 11-year period and to identify disease- and provider-related influences.
  • METHODS: Subjects presented to the Department of Otolaryngology-Head and Neck Surgery and the Department of Neurosurgery for management of unilateral vestibular schwannoma from 1997 through 2007, with at least two visits within the first year of presentation.
  • The proportion of patients for whom initial management consisted of observation, surgical resection, or radiation therapy was determined, and the relative influence of study year, patient age, hearing status, and tumor size was analyzed.
  • There were no changes in mean age or hearing status at diagnosis, but mean tumor size declined significantly.
  • Tumors that were surgically removed were on average 11.6 mm larger than those that were observed.
  • The increasing frequency over time of observation relative to surgery was significant even after controlling for age, hearing status, and tumor size.
  • CONCLUSIONS: Among patients managed by our center, there has been a significant shift in management of vestibular schwannomas over the last decade, with increasing tendency towards observation.
  • [MeSH-major] Ear Neoplasms / therapy. Neuroma, Acoustic / therapy

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  • (PMID = 19877188.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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30. Cayé-Thomasen P, Borup R, Stangerup SE, Thomsen J, Nielsen FC: Deregulated genes in sporadic vestibular schwannomas. Otol Neurotol; 2010 Feb;31(2):256-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Deregulated genes in sporadic vestibular schwannomas.
  • OBJECTIVE: In search of genes associated with vestibular schwannoma tumorigenesis, this study examines the gene expression in human vestibular nerve versus vestibular schwannoma tissue samples using microarray technology.
  • MATERIAL AND METHODS: RNA was extracted from 3 vestibular nerves (serving as control) and 16 solid, sporadic vestibular schwannomas.
  • Differentially expressed genes were identified as differences between control and tumor tissue larger than 2-fold, with a conservative p value of less than 0.000161 and means of differences greater than 25.
  • RESULTS: Eighty-seven probe sets, representing 78 genes, were significantly up- or down-regulated in tumor tissue.
  • The deregulated genes were matched against established gene ontology, revealing that 8 of the up-regulated genes are involved in regulation of the cell cycle, 6 in cell morphogenesis, 8 in cell development, 11 in cell differentiation, 6 in cell death, 13 in cell adhesion, 9 in extracellular matrix, and 50 in protein binding (overlapping occurring).
  • Gene annotation enrichment analyses of the clustered genes showed significant enrichment of annotations for the extracellular matrix (p < 0.0002), cell adhesion (p < 0.0001), and protein binding (p < 0.0004).
  • CONCLUSION: We conclude that a number of transcripts are deregulated in sporadic vestibular schwannomas, and that several of these have functional annotations implicated in tumorigenesis.
  • Specifically, genes involved in extracellular matrix function, cell adhesion, and protein binding seem to be of potential importance.
  • [MeSH-major] Ear Neoplasms / genetics. Gene Expression Regulation, Neoplastic / genetics. Neuroma, Acoustic / genetics
  • [MeSH-minor] Adult. Aged. Apoptosis / genetics. Cell Adhesion / genetics. Cell Cycle / genetics. Cell Differentiation / genetics. Extracellular Matrix / genetics. Female. Humans. Male. Middle Aged. Morphogenesis / genetics. Oligonucleotide Array Sequence Analysis. Prospective Studies. RNA, Messenger / biosynthesis. RNA, Messenger / genetics. Vestibular Nerve / metabolism

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  • (PMID = 19816230.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger
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31. Whitehouse K, Foroughi M, Shone G, Hatfield R: Vestibular schwannomas - when should conservative management be reconsidered? Br J Neurosurg; 2010 Apr;24(2):185-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vestibular schwannomas - when should conservative management be reconsidered?
  • OBJECTIVE: To document the natural history of vestibular schwannomas treated conservatively, and to find if there are any predictive factors for growth and need for active intervention.
  • SUBJECTS: Eighty-eight patients managed conservatively for unilateral vestibular schwannoma and that have had at least two radiological investigations.
  • RESULTS: Of the 88 patients, the average size of schwannoma at diagnosis was 10.88 mm.
  • 51.1% of schwannomas grew, 12.5% shrank and 36.4% remained the same size.
  • [MeSH-major] Microsurgery / methods. Neuroma, Acoustic / pathology. Neuroma, Acoustic / radiography. Radiosurgery / methods
  • [MeSH-minor] Aged. Disease Progression. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Retrospective Studies. Risk Factors. Treatment Outcome. Tumor Burden

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  • (PMID = 19886818.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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32. Lobato-Polo J, Kondziolka D, Zorro O, Kano H, Flickinger JC, Lunsford LD: Gamma knife radiosurgery in younger patients with vestibular schwannomas. Neurosurgery; 2009 Aug;65(2):294-300; discussion 300-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gamma knife radiosurgery in younger patients with vestibular schwannomas.
  • OBJECTIVE: Management options for patients with vestibular schwannoma include observation, surgical resection, stereotactic radiosurgery (SRS), and stereotactic radiation therapy.
  • We studied tumor response and clinical outcomes after SRS in such patients.
  • METHODS: We reviewed long-term outcomes in 55 patients with vestibular schwannomas.
  • The median tumor volume was 1.7 mm.
  • The median tumor margin dose was 13.0 Gy (range, 11-20 Gy).
  • At the last assessment, facial and trigeminal nerve function was preserved in 98.2% and 96.4% of patients, respectively; the only facial deficit (House-Brackmann grade III) occurred in a patient who received a tumor dose of 20 Gy early in our experience (1988).
  • No patient developed a secondary radiation-related tumor.
  • CONCLUSION: Our experience indicates that GK SRS is an effective management strategy for younger patients with vestibular schwannoma, most of whom have no additional cranial nerve dysfunction.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Neuroma, Acoustic / surgery. Postoperative Complications / epidemiology. Radiosurgery / statistics & numerical data. Vestibular Nerve / surgery
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Age Factors. Cochlear Nerve / physiopathology. Cochlear Nerve / radiation effects. Facial Nerve / physiopathology. Facial Nerve / radiation effects. Facial Nerve Injuries / epidemiology. Facial Nerve Injuries / prevention & control. Female. Hearing Loss, Sensorineural / epidemiology. Hearing Loss, Sensorineural / prevention & control. Humans. Male. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / prevention & control. Neoplasm Recurrence, Local / surgery. Outcome Assessment (Health Care). Radiation Dosage. Retrospective Studies. Treatment Outcome. Trigeminal Nerve / physiopathology. Trigeminal Nerve / radiation effects. Trigeminal Nerve Diseases / epidemiology. Trigeminal Nerve Diseases / prevention & control. Young Adult

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  • (PMID = 19625908.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Chin KF, Babar J, Tzifa K, Chavda SV, Irving RM: Vestibular schwannomas with fluid-fluid level. J Laryngol Otol; 2007 Sep;121(9):902-6
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  • [Title] Vestibular schwannomas with fluid-fluid level.
  • Vestibular schwannomas containing cystic parts are common, but it is extremely rare for a vestibular schwannoma to contain fluid-fluid levels.
  • In this report, we present two cases of vestibular schwannoma with magnetic resonance imaging findings of a fluid-fluid level, and we discuss the radiological features and possible mechanism of fluid-fluid level formation.
  • [MeSH-major] Cyst Fluid. Neuroma, Acoustic / diagnosis

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  • (PMID = 17320004.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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34. Roche PH, Ribeiro T, Khalil M, Soumare O, Thomassin JM, Pellet W: Recurrence of vestibular schwannomas after surgery. Prog Neurol Surg; 2008;21:89-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrence of vestibular schwannomas after surgery.
  • The issue of recurrence of vestibular schwannomas is poorly studied by the surgical literature and is probably underestimated.
  • This long-term event is mainly due to regrowth of microfragments that have been left in the operative field along the course of the facial nerve or at the surface of the pons.
  • Management of recurrence depends on the tumor size and patient's condition.
  • Prospective long-term follow-up studies using serial MR imaging after radical removal should bring reliable data about the incidence of vestibular schwannoma recurrence.
  • [MeSH-major] Neoplasm Recurrence, Local / epidemiology. Neuroma, Acoustic / surgery

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  • (PMID = 18810204.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 7
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35. Shchekut'ev GA, Shimanskiĭ VN, Ogurtsova AA, Semenov MS: [Identification of the cochlear nerve in surgical removal of vestibular schwannomas]. Zh Vopr Neirokhir Im N N Burdenko; 2009 Jul-Sep;(3):10-3; discussion 13-4
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  • [Title] [Identification of the cochlear nerve in surgical removal of vestibular schwannomas].
  • Review of methods which allow intraoperative identifying and monitoring of cochlear and facial nerves in resection of vestibular schwannomas is presented.
  • We describe a case of successful identification and functional preservation of facial and cochlear nerves in a patient with acoustic neuroma.
  • According to some authors, application of intraoperative neurophysiological techniques in surgery of vestibular schwannomas allows to preserve not only anatomical but also functional integrity of neural structures as well.
  • [MeSH-major] Cochlear Nerve / physiology. Hearing Loss, Sensorineural / prevention & control. Neuroma, Acoustic / surgery. Neurosurgical Procedures / methods

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  • (PMID = 20088443.001).
  • [ISSN] 0042-8817
  • [Journal-full-title] Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko
  • [ISO-abbreviation] Zh Vopr Neirokhir Im N N Burdenko
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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36. Doherty JK, Friedman RA: Controversies in building a management algorithm for vestibular schwannomas. Curr Opin Otolaryngol Head Neck Surg; 2006 Oct;14(5):305-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Controversies in building a management algorithm for vestibular schwannomas.
  • PURPOSE OF REVIEW: The present review examines the various mainstream treatment options, benefits and risks, and controversies involved in developing a management algorithm for treatment of vestibular schwannoma.
  • RECENT FINDINGS: Advances in microsurgery and radiosurgery have made tremendous contributions to management of vestibular schwannoma; however, considerable controversy still exists.
  • The auditory and facial nerve functional outcomes have improved with use of intraoperative monitoring for vestibular schwannoma removal and with lower radiosurgery doses; however, risks to the facial and auditory nerves still exist.
  • Observing vestibular schwannomas for growth with serial magnetic resonance imaging is an increasingly popular option for small vestibular schwannomas that allows patients to enjoy hearing and facial function.
  • SUMMARY: The risks and benefits of each treatment option must be weighed for each patient, and management decisions regarding vestibular schwannomas should be individualized for each patient depending on tumor anatomy, patient preferences, and symptoms.
  • [MeSH-major] Algorithms. Ear, Inner / surgery. Neuroma, Acoustic / therapy
  • [MeSH-minor] Cochlear Nerve / physiology. Facial Nerve / physiology. Hearing Loss / prevention & control. Humans. Magnetic Resonance Imaging. Microsurgery. Neurofibromatosis 2 / surgery. Neurofibromatosis 2 / therapy. Radiosurgery. Treatment Outcome

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  • [CommentIn] Curr Opin Otolaryngol Head Neck Surg. 2006 Oct;14(5):297-8 [16974140.001]
  • (PMID = 16974142.001).
  • [ISSN] 1068-9508
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 63
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37. Yomo S, Arkha Y, Delsanti C, Roche PH, Thomassin JM, Régis J: Repeat gamma knife surgery for regrowth of vestibular schwannomas. Neurosurgery; 2009 Jan;64(1):48-54; discussion 54-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Repeat gamma knife surgery for regrowth of vestibular schwannomas.
  • OBJECTIVE: Gamma knife surgery (GKS) has become established as a minimally invasive treatment modality for patients with vestibular schwannomas.
  • Treatment failure and/or tumor regrowth, however, is occasionally encountered, and microsurgical resection is usually warranted in such cases.
  • The goal of this study was to investigate whether repeat GKS is an effective treatment for recurrent vestibular schwannomas and to assess the conservation of residual neurological function.
  • METHODS: Between July 1992 and December 2007, 1951 patients harboring a unilateral vestibular schwannoma were treated with GKS.
  • Of these, 48 patients (2.5%) had to undergo a subsequent intervention because of progression or regrowth of the tumor.
  • Repeat GKS was performed in a total of 15 patients, 8 of whom had more than 2 years of follow-up and were eligible to be enrolled in the present study.
  • The median tumor volume was 0.51 and 1.28 mL at the initial and second GKS treatments, respectively.
  • Six patients demonstrated a significant reduction in tumor volume.
  • In 1 patient, the final tumor volume was less than the initial volume.
  • The other 2 patients showed stabilization of tumor growth.
  • Neither aggravation of facial nerve dysfunction nor other neurological deficits secondary to GKS were observed.
  • CONCLUSION: This is the first report to address repeat GKS for vestibular schwannomas.
  • After long-term follow-up, repeat GKS with a low marginal dose seems to be a safe and effective treatment in selected patients harboring regrowth of small vestibular schwannomas that have previously been treated with GKS.
  • [MeSH-major] Neoplasm Recurrence, Local / surgery. Neuroma, Acoustic / surgery. Radiosurgery

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  • (PMID = 19050660.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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38. Welling DB, Packer MD, Chang LS: Molecular studies of vestibular schwannomas: a review. Curr Opin Otolaryngol Head Neck Surg; 2007 Oct;15(5):341-6
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  • [Title] Molecular studies of vestibular schwannomas: a review.
  • PURPOSE OF REVIEW: To summarize advances in understanding the molecular biology of vestibular schwannomas over the past year.
  • RECENT FINDINGS: The role of the neurofibromatosis type 2 protein, denoted as merlin or schwannomin, in embryonic development, cellular adherence, and in cell proliferation has become better elucidated in the past year.
  • Likewise, the role of merlin in Schwann cell-axon interaction has been studied.
  • Neurofibromatosis type 2 screening guidelines for young patients with solitary vestibular schwannomas have been published.
  • The role of electromagnetic radiation via cellular and portable telephones as a predisposing factor to vestibular schwannoma formation has also been the topic of several studies.
  • [MeSH-major] Neuroma, Acoustic / genetics
  • [MeSH-minor] Animals. Cell Phones. Embryonic Development. Genetic Testing. Humans. Mutation. Neurofibromatosis 2 / genetics. Neurofibromin 2 / metabolism. Oligonucleotide Array Sequence Analysis

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  • (PMID = 17823551.001).
  • [ISSN] 1068-9508
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neurofibromin 2
  • [Number-of-references] 36
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39. Samii M, Gerganov V, Samii A: Hearing preservation after complete microsurgical removal in vestibular schwannomas. Prog Neurol Surg; 2008;21:136-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hearing preservation after complete microsurgical removal in vestibular schwannomas.
  • AIM: To evaluate and present the treatment strategy and hearing preservation in a recent series of vestibular schwannoma cases.
  • RESULTS: The anatomical integrity of the cochlear nerve was preserved in 75.8% of the cases.
  • It was highest in small tumors--60% in class T1 and 72% in class T2.
  • In tumors extending to and compressing the brain stem, preservation of some hearing was possible in up to 43%.
  • CONCLUSIONS: Vestibular schwannomas are benign lesions whose total removal leads to definitive healing of the patient.
  • Using the retrosigmoid approach with the patient in the semi-sitting position, hearing preservation is possible even for large schwannomas.
  • [MeSH-major] Hearing Loss / prevention & control. Microsurgery. Neuroma, Acoustic / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Audiometry. Cochlear Nerve / physiopathology. Cohort Studies. Humans. Middle Aged. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 18810211.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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40. Møller MN, Werther K, Nalla A, Stangerup SE, Thomsen J, Bøg-Hansen TC, Nielsen HJ, Cayé-Thomasen P: Angiogenesis in vestibular schwannomas: expression of extracellular matrix factors MMP-2, MMP-9, and TIMP-1. Laryngoscope; 2010 Apr;120(4):657-62
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  • [Title] Angiogenesis in vestibular schwannomas: expression of extracellular matrix factors MMP-2, MMP-9, and TIMP-1.
  • OBJECTIVES/HYPOTHESIS: Vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) are potent mediators of tumor angiogenesis.
  • It has been demonstrated that vestibular schwannoma VEGF expression correlates with tumor growth pattern, whereas knowledge on the expression of MMPs is lacking.
  • This study targets the angiogenic process by investigation of tumor expression of MMP-2, MMP-9, and tissue inhibitors of metalloproteinase (TIMP)-1.
  • A possible correlation with gender, patient age, symptom duration, tumor size, and the absolute and relative growth rate is explored.
  • STUDY DESIGN: Prospective vestibular schwannoma tissue sampling for ELISA and immunohistochemical determination of MMP-2, MMP-9 and TIMP-1.
  • METHODS: Thirty-four patients with a sporadic, noncystic, vestibular schwannoma were selected prospectively.
  • Repeated, preoperative magnetic resonance imaging determined the tumor growth pattern.
  • Following translabyrinthine resection, an enzyme-linked immunosorbent assay was used for determination of the MMP-2, MMP-9, and TIMP-1 concentration in tumor sample homogenates.
  • Immunohistochemical labeling was performed in 12 randomly selected tumors.
  • RESULTS: : All tumor homogenates expressed measurable MMP-9, MMP-2, and TIMP-1.
  • Immunolabeling localized MMP-9 expression to the tumor cells, whereas MMP-2 and TIMP-1 was found interstitially.
  • A significant correlation existed between the concentration MMP-9 and absolute tumor growth rate, whereas a weak correlation occurred for the relative growth rate.
  • CONCLUSIONS: Vestibular schwannomas express MMP-2, MMP-9, and TIMP-1 and the tumor concentration of MMP-9 correlates with absolute tumor growth rate, but not with age, gender, symptom duration, or preoperative tumor size.
  • We conclude that MMP-9 appears to be involved in the growth of vestibular schwannomas.
  • [MeSH-major] Matrix Metalloproteinase 2 / biosynthesis. Matrix Metalloproteinase 9 / biosynthesis. Neovascularization, Pathologic / enzymology. Neuroma, Acoustic / blood supply. RNA, Neoplasm / genetics. Tissue Inhibitor of Metalloproteinase-1 / genetics
  • [MeSH-minor] Adult. Aged. Enzyme-Linked Immunosorbent Assay. Female. Follow-Up Studies. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Prospective Studies

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  • (PMID = 20205165.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Neoplasm; 0 / Tissue Inhibitor of Metalloproteinase-1; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9
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41. Nicoucar K, Momjian S, Vader JP, De Tribolet N: Surgery for large vestibular schwannomas: how patients and surgeons perceive quality of life. J Neurosurg; 2006 Aug;105(2):205-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgery for large vestibular schwannomas: how patients and surgeons perceive quality of life.
  • OBJECT: The aim of this study was to assess the consequences of total removal of a large vestibular schwannoma on the patient's symptoms and quality of life (QOL).
  • METHODS: A questionnaire regarding preoperative and postoperative symptoms with measures of both daily and global QOL and a modified 36-Item Short Form Health Survey (SF-36) QOL instrument were sent to 103 patients who had undergone surgery via a retrosigmoid approach for total removal of a Grade III or IV vestibular schwannoma.
  • Forty-six (64%) of the schwannomas were Grade IV and 26 (36%) were Grade III.
  • Patients with large vestibular schwannomas had lower scores in all SF-36 categories except pain compared with data from other studies.
  • CONCLUSIONS: Surgery for a large vestibular schwannoma has a significant impact on the patient's QOL.
  • [MeSH-major] Attitude of Health Personnel. Neuroma, Acoustic / surgery. Postoperative Complications / psychology. Quality of Life / psychology

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  • (PMID = 17219824.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Régis J, Roche PH, Delsanti C, Thomassin JM, Ouaknine M, Gabert K, Pellet W: Modern management of vestibular schwannomas. Prog Neurol Surg; 2007;20:129-41
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  • [Title] Modern management of vestibular schwannomas.
  • Within the last 3 decades, microsurgery and stereotactic radiosurgery (SRS) have become well-established management options for vestibular schwannomas (VSs).
  • A long-term tumor control rate of 97%, transient facial palsy lower than 1%, and a probability of functional hearing preservation between 50 and 95% was achieved in this large series of patients treated with state-of-the-art SRS.
  • [MeSH-major] Neuroma, Acoustic / surgery. Postoperative Complications / epidemiology. Radiosurgery

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  • (PMID = 17317981.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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43. Roche PH, Bouvier C, Chinot O, Figarella-Branger D: Genesis and biology of vestibular schwannomas. Prog Neurol Surg; 2008;21:24-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genesis and biology of vestibular schwannomas.
  • This review chapter is a synthesis of the recent literature about pathogenesis of schwannomas with emphasis on vestibular schwannomas (VSs).
  • The cornerstone of cellular transformation and proliferation of Schwann cells toward schwannomas has been attributed to the nonexpression of normal schwannomin/merlin (S/M) by these cells.
  • The understanding of this mechanism has been gained from molecular genetic studies of neurofibromatosis type 2 (NF2) patients, in whom mutations of a tumor suppressor gene (NF2 gene) was clearly identified.
  • Lack of normal S/M protein in the schwannoma cell is due to gene mutation in 50% of sporadic VSs.
  • The exact interactions of S/M with extracellular matrix, membranous glycoprotein and cytoskeleton are not fully understood.
  • However, it is recognized that these interactions activate several pathways that might regulate cell-cycle process, apoptosis and intercellular interaction.
  • Apart from the involvement of the S/M pathway, the authors review the potential role of other genetic abnormalities and growing factors that are supposed to be involved in the pathogenesis of vs. Understanding the pathways of action and regulation of S/M may provide the basics for identifying potential therapeutic targets, which is of paramount importance for a better management of NF2 patients.
  • [MeSH-major] Genes, Neurofibromatosis 2 / physiology. Neurofibromin 2 / physiology. Neuroma, Acoustic / genetics. Neuroma, Acoustic / pathology

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  • (PMID = 18810196.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Neurofibromin 2
  • [Number-of-references] 43
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44. Friedman WA: Linear accelerator radiosurgery for vestibular schwannomas. Prog Neurol Surg; 2008;21:228-37
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  • [Title] Linear accelerator radiosurgery for vestibular schwannomas.
  • The treatment paradigm uses the rotating high-energy X-ray output of the LINAC to focus many hundreds of 'beam equivalents' on intracranial or spinal targets.
  • At the University of Florida, 450 vestibular schwannomas have been treated.
  • Tumor control has been achieved in 90% (5- year actuarial data).
  • Since reducing the treatment dose to 1,250 cGy, in 1994, the incidence of facial and trigeminal nerve injury has been <1%.
  • No instance of malignant tumor transformation has been observed.
  • We believe that radiosurgery is the treatment of choice for smaller vestibular schwannomas.
  • [MeSH-major] Neuroma, Acoustic / surgery. Particle Accelerators / instrumentation. Radiosurgery / instrumentation

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  • (PMID = 18810224.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 22
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45. Kramer F, Stöver T, Warnecke A, Diensthuber M, Lenarz T, Wissel K: BDNF mRNA expression is significantly upregulated in vestibular schwannomas and correlates with proliferative activity. J Neurooncol; 2010 May;98(1):31-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] BDNF mRNA expression is significantly upregulated in vestibular schwannomas and correlates with proliferative activity.
  • The expression of neurotrophic factors, such as artemin, glial cell line-derived neurotrophic factor (GDNF), neurturin, transforming growth factors (TGF)-beta1/beta2 and brain-derived neurotrophic factor (BDNF), is enhanced in vestibular schwannomas compared to peripheral nerves.
  • Vestibular schwannoma arising from Schwann cells of the vestibular nerve are mostly benign and slow-growing.
  • Most of the pathogenic mechanisms regulating the vestibular schwannoma growth process are unknown.
  • However, molecular mechanisms interfering with regulation of the vestibular schwannoma growth also modulated by mitogenic factors have to be identified.
  • Neurotrophic factors are involved in regulation of developmental processes in neuronal tissues and regeneration after peripheral nerve trauma and also reveal mitogenic effects on glial cell populations.
  • Gene expression profiles of artemin, BDNF, GDNF, TGF-beta1/beta2 and Ret were determined in the vestibular schwannoma in comparison to the peripheral nerve tissues by using semiquantitative RT-PCR.
  • A significant higher BDNF expression was observed in the vestibular schwannoma, whereas gene expression of artemin and GDNF was upregulated in peripheral nerves.
  • The correlation between LI and BDNF, TGF-beta1 and Ret was found to be significant in the vestibular schwannoma.
  • Our results demonstrate a coherence between BDNF expression and proliferative activity in the vestibular schwannoma.
  • Based on these results, we propose a pivotal role for BDNF in modulating the vestibular schwannoma growth.
  • [MeSH-major] Brain-Derived Neurotrophic Factor / genetics. Cell Proliferation. Gene Expression Regulation, Neoplastic / physiology. Neuroma, Acoustic / genetics. RNA, Messenger / metabolism. Up-Regulation / physiology
  • [MeSH-minor] Adult. Aged. Female. Glial Cell Line-Derived Neurotrophic Factor / genetics. Glial Cell Line-Derived Neurotrophic Factor / metabolism. Humans. Ki-67 Antigen / metabolism. Male. Middle Aged. Nerve Tissue Proteins / genetics. Nerve Tissue Proteins / metabolism. Peripheral Nerves / metabolism. Statistics as Topic / methods. Statistics, Nonparametric. Transforming Growth Factor beta1 / genetics. Transforming Growth Factor beta1 / metabolism. Transforming Growth Factor beta2 / genetics. Transforming Growth Factor beta2 / metabolism. Young Adult

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  • (PMID = 19937367.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ARTN protein, human; 0 / Brain-Derived Neurotrophic Factor; 0 / Glial Cell Line-Derived Neurotrophic Factor; 0 / Ki-67 Antigen; 0 / Nerve Tissue Proteins; 0 / RNA, Messenger; 0 / Transforming Growth Factor beta1; 0 / Transforming Growth Factor beta2
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46. Coca Pelaz A, Fernández Lisa C, Gómez JR, Rodrigo JP, Llorente JL, Suárez C: [Complete facial palsy following surgery for acoustic nerve neurinoma: evolution and associated ophthalmological complications]. Acta Otorrinolaringol Esp; 2008 May;59(5):223-7
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  • [Title] [Complete facial palsy following surgery for acoustic nerve neurinoma: evolution and associated ophthalmological complications].
  • [Transliterated title] Parálisis facial completa tras cirugía de neurinoma del acústico: evolución y complicaciones oftalmológicas asociadas.
  • OBJECTIVE: To evaluate the fraction of patients recovering to normal function after complete facial nerve paralysis secondary to acoustic neuroma surgery, and also to address the ophthalmologic complications associated with it and the therapeutic options.
  • MATERIAL AND METHOD: We performed a retrospective review of 30 cases operated on in our department for acoustic neuroma and who, despite anatomical preservation of the facial nerve, developed a complete post-operative facial nerve paralysis (grade VI of House-Brackmann [HB]).
  • RESULTS: Only 5 of the 30 cases studied (16.6 %) recovered to normal facial nerve function (HB grade I).
  • [MeSH-major] Cochlear Nerve / pathology. Cochlear Nerve / surgery. Corneal Ulcer / etiology. Facial Paralysis / etiology. Facial Paralysis / physiopathology. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Peripheral Nervous System Neoplasms / pathology. Peripheral Nervous System Neoplasms / surgery. Postoperative Complications
  • [MeSH-minor] Adult. Aged. Disease Progression. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 18501157.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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47. Bennett M, Haynes DS: Surgical approaches and complications in the removal of vestibular schwannomas. 2007. Neurosurg Clin N Am; 2008 Apr;19(2):331-43, vii
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical approaches and complications in the removal of vestibular schwannomas. 2007.
  • Vestibular schwannomas are benign tumors that usually originate from the balance portion of cranial nerve VIII.
  • The treatment options currently available for vestibular schwannomas include observation with serial imaging, stereotactic radiation, and microsurgical removal.
  • Although the ultimate goal in treatment of vestibular schwannomas is preservation of life, the best option for each patient depends on symptoms, tumor size, tumor location, and the patient's general health and age.
  • Surgical exposure of the cerebellopontine angle for removal of vestibular schwannomas can be performed safely via a translabyrinthine, retrosigmoid, and middle fossa approach.
  • The goal of surgery is complete eradication of tumor with preservation of hearing and facial nerve function when possible.
  • [MeSH-major] Neuroma, Acoustic / history. Neurosurgical Procedures / history. Otologic Surgical Procedures / history

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  • (PMID = 18534343.001).
  • [ISSN] 1558-1349
  • [Journal-full-title] Neurosurgery clinics of North America
  • [ISO-abbreviation] Neurosurg. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Biography; Classical Article; Historical Article; Journal Article
  • [Publication-country] United States
  • [Personal-name-as-subject] Bennett M; Haynes DS
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48. Bennett M, Haynes DS: Surgical approaches and complications in the removal of vestibular schwannomas. Otolaryngol Clin North Am; 2007 Jun;40(3):589-609, ix-x
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical approaches and complications in the removal of vestibular schwannomas.
  • Vestibular schwannomas are benign tumors that usually originate from the balance portion of cranial nerve VIII.
  • The treatment options currently available for vestibular schwannomas include observation with serial imaging, stereotactic radiation, and microsurgical removal.
  • Although the ultimate goal in treatment of vestibular schwannomas is preservation of life, the best option for each patient depends on symptoms, tumor size, tumor location, and the patient's general health and age.
  • Surgical exposure of the cerebellopontine angle for removal of vestibular schwannomas can be performed safely via a translabyrinthine, retrosigmoid, and middle fossa approach.
  • The goal of surgery is complete eradication of tumor with preservation of hearing and facial nerve function when possible.
  • [MeSH-major] Ear Neoplasms / surgery. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods
  • [MeSH-minor] Cerebrospinal Fluid Otorrhea / epidemiology. Cerebrospinal Fluid Otorrhea / etiology. Facial Nerve Diseases / epidemiology. Facial Nerve Diseases / etiology. Headache / epidemiology. Headache / etiology. Humans. Meningitis / epidemiology. Meningitis / etiology. Neoplasm Recurrence, Local. Postoperative Complications. Postural Balance / physiology. Tinnitus / epidemiology. Tinnitus / etiology

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  • (PMID = 17544697.001).
  • [ISSN] 0030-6665
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 33
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49. Cross JJ, Baguley DM, Antoun NM, Moffat DA, Prevost AT: Reproducibility of volume measurements of vestibular schwannomas - a preliminary study. Clin Otolaryngol; 2006 Apr;31(2):123-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reproducibility of volume measurements of vestibular schwannomas - a preliminary study.
  • OBJECTIVE: A preliminary study to investigate the intra-observer and inter-observer variability of measurements of vestibular schwannoma volume using an area-tracing and linear dimension measurement method.
  • SETTING: Ambulatory patients with known vestibular schwannoma attending a tertiary referral centre.
  • PARTICIPANTS: Twenty-three patients with 26 vestibular schwannomas aged 29-80 years old.
  • CONCLUSIONS: Volume measurements in vestibular schwannoma are variable even when the measurements are made by the same observer on identical images.
  • [MeSH-major] Neuroma, Acoustic / pathology

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  • (PMID = 16620331.001).
  • [ISSN] 1749-4478
  • [Journal-full-title] Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • [ISO-abbreviation] Clin Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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50. Lee WJ, Isaacson JE: Postoperative imaging and follow-up of vestibular schwannomas. Otol Neurotol; 2005 Jan;26(1):102-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Postoperative imaging and follow-up of vestibular schwannomas.
  • OBJECTIVE: No standards exist regarding patient follow-up after complete vestibular schwannoma resection.
  • Questions concerned years in practice, experience with vestibular schwannoma surgery, and postoperative follow-up algorithms given the scenario of complete gross tumor removal.
  • There was no correlation between number of magnetic resonance imaging scans and either years in practice or tumor experience.
  • CONCLUSION: There remains no standard postoperative imaging algorithm for patients after complete vestibular schwannoma resection.
  • [MeSH-major] Magnetic Resonance Imaging. Neuroma, Acoustic / surgery. Postoperative Complications / diagnosis
  • [MeSH-minor] Algorithms. Data Collection. Follow-Up Studies. Humans. Neurology. Neurosurgery. Otolaryngology. Specialization. Vestibular Nerve / pathology

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  • [CommentIn] Otol Neurotol. 2005 May;26(3):551-2; author reply 552 [15891667.001]
  • (PMID = 15699728.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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51. Sabol Z, Kipke-Sabol L, Miklić P, Hajnsek-Propadalo S, Sabol F: [Neurofibromatosis type 2 (central neurofibromatosis or bilateral acoustic neuromas, vestibular schwannomas): from phenotype to gene]. Lijec Vjesn; 2006 Sep-Oct;128(9-10):309-16
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  • [Title] [Neurofibromatosis type 2 (central neurofibromatosis or bilateral acoustic neuromas, vestibular schwannomas): from phenotype to gene].
  • Neurofibromatosis type 2 (NF2) is an autosomal dominant disease that predisposes to bilateral vestibular schwannomas (neurinomas), other central and peripheral nervous system tumours (multiple meningeomas and neurofibromas) and ocular abnormalities (cataract).
  • NF2 has a variable clinical presentation, with two basic types: severe type having early onset and progressive growth of tumors and the milder type having later onset and less aggressive course.
  • The genotype-phenotype correlations indicate a greater variability of clinical disease expression.
  • [MeSH-major] Neurofibromatosis 2 / genetics. Neuroma, Acoustic / genetics


52. Dagain A, Dutertre G, Pouit B, Dulou R, Delmas JM, Poncet JL, Desgeorges M, Pernot P: [Recurrent giant cystic vestibular schwannomas: role of cystoperitoneal shunt]. Neurochirurgie; 2010 Aug;56(4):350-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Recurrent giant cystic vestibular schwannomas: role of cystoperitoneal shunt].
  • [Transliterated title] Schwannomes vestibulaires kystiques géants: intérêt du drainage kystopéritonéal.
  • INTRODUCTION: Surgical removal of giant cystic vestibular schwannomas is difficult because of adherences between the cyst membrane, brainstem, and the VII-VIII nerve complex.
  • The aim of this study was to analyze the role of the palliative cystoperitoneal shunt in giant cystic vestibular schwannomas.
  • MATERIALS AND METHODS: Eighty-eight patients with a diagnosis of stage III or IV vestibular schwannoma were managed surgically from January 2000 to December 2005 in our department.
  • Six schwannomas were deemed to be cystic according to the following criteria: a voluminous cystic component with mass effect causing symptoms as well as radiological and intraoperative identification of cystic elements.
  • RESULTS: Complete tumor removal was achieved in two patients.
  • CONCLUSIONS: The cystoperitoneal shunt with no valve is a valid palliative surgical solution to remove brain stem compression.
  • [MeSH-major] Ear Neoplasms / surgery. Neuroma, Acoustic / surgery. Neurosurgical Procedures
  • [MeSH-minor] Aged. Aged, 80 and over. Central Nervous System Cysts / pathology. Central Nervous System Cysts / surgery. Drainage. Facial Nerve / pathology. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local. Nerve Compression Syndromes / etiology. Nerve Compression Syndromes / surgery. Palliative Care. Peritoneum / surgery. Treatment Failure

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  • [Copyright] Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20557908.001).
  • [ISSN] 1773-0619
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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53. Chu SM, Young YH: Ipsilateral and contralateral vestibular schwannomas in unilateral long-term deaf ears. Eur Arch Otorhinolaryngol; 2007 Jun;264(6):693-6
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  • [Title] Ipsilateral and contralateral vestibular schwannomas in unilateral long-term deaf ears.
  • In the past decade, we have encountered two patients with unilateral long-term deaf ear having vestibular schwannoma.
  • Although similar physiological findings were disclosed on the deaf ears, MRI scan demonstrated vestibular schwannoma on the different side, that is, one in deaf ear and the other in hearing ear.
  • For the former, absent ABR and caloric results indicate that the tumor originates from the superior vestibular nerve.
  • In contrast with the latter, normal ABR and caloric responses, but absent vestibular-evoked myogenic potentials on the hearing ear imply that the tumor originates from the inferior vestibular nerve.
  • The ipsilateral tumor on the deaf ear underwent intracranial surgical excision, followed by radiosurgery due to tumor recurrence 10 years later, while the contralateral one on the only hearing ear received radiosurgery only.
  • [MeSH-major] Deafness. Neuroma, Acoustic / diagnosis
  • [MeSH-minor] Audiometry, Pure-Tone. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Neoplasm Recurrence, Local. Radiosurgery / methods. Stereotaxic Techniques

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  • (PMID = 17476518.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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54. Lescanne E, François P, Velut S: Cerebellopontine cistern: microanatomy applied to vestibular schwannomas. Prog Neurol Surg; 2008;21:43-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cerebellopontine cistern: microanatomy applied to vestibular schwannomas.
  • The microanatomy of the cerebellopontine cistern (CPC) is of interest to many surgeons and has been the subject of controversial works especially concerning the study of the subarachnoid space in the internal acoustic meatus (IAM).
  • It contains in its upper part the trigeminal nerve with the superior petrosal vein.
  • The anatomy of the meningeal layers within the IAM is discussed especially concerning 'the arachnoidal cleavage plane' in acoustic neuroma surgery.
  • [MeSH-major] Cerebellopontine Angle / pathology. Cisterna Magna / pathology. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery

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  • (PMID = 18810198.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 39
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55. Mick P, Westerberg BD, Ngo R, Akagami R: Growing vestibular schwannomas: what happens next? Otol Neurotol; 2009 Jan;30(1):101-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Growing vestibular schwannomas: what happens next?
  • OBJECTIVE: To determine the subsequent growth patterns in vestibular schwannomas shown to be growing on serial imaging.
  • PATIENTS: Patients with tumors that demonstrated growth of greater than 1 mm/yr between 2 consecutive scans (magnetic resonance or computed tomography) and had at least 1 follow-up scan were included.
  • MAIN OUTCOME MEASURE(S): Maximum dimension along the axis of the internal auditory canal was measured for intracanalicular tumors, whereas for extracanalicular tumors, maximal dimension along any orientation was used.
  • Of the growing tumors, 63.9% continued to grow, 30.6% stayed the same size, and 5.6% regressed in size.
  • CONCLUSION: Most vestibular schwannomas identified to be growing are likely to continue to grow on subsequent serial imaging.
  • These results are useful in clinical decision making and counseling patients with growing vestibular schwannomas.
  • [MeSH-major] Neuroma, Acoustic / pathology
  • [MeSH-minor] Cell Division. Ear Canal / pathology. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Patient Selection. Remission, Spontaneous. Tomography, X-Ray Computed

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  • (PMID = 19108071.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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56. Backous DD, Pham HT: Guiding patients through the choices for treating vestibular schwannomas: balancing options and ensuring informed consent. Otolaryngol Clin North Am; 2007 Jun;40(3):521-40, viii-ix
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Guiding patients through the choices for treating vestibular schwannomas: balancing options and ensuring informed consent.
  • Counseling patients who are diagnosed with vestibular schwannomas, formerly known as acoustic neuromas, can be challenging.
  • [MeSH-major] Choice Behavior. Informed Consent. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Patient Education as Topic

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  • (PMID = 17544694.001).
  • [ISSN] 0030-6665
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 79
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57. Backous DD, Pham HT: Guiding patients through the choices for treating vestibular schwannomas: balancing options and ensuring informed consent. 2007. Neurosurg Clin N Am; 2008 Apr;19(2):379-92, viii
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Guiding patients through the choices for treating vestibular schwannomas: balancing options and ensuring informed consent. 2007.
  • Counseling patients who are diagnosed with vestibular schwannomas, formerly known as acoustic neuromas, can be challenging.
  • [MeSH-major] Informed Consent / history. Neuroma, Acoustic / history. Patient Education as Topic / history

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  • (PMID = 18534346.001).
  • [ISSN] 1558-1349
  • [Journal-full-title] Neurosurgery clinics of North America
  • [ISO-abbreviation] Neurosurg. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Biography; Classical Article; Historical Article; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Personal-name-as-subject] Backous DD; Pham HT
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58. Jayashankar N, Morwani KP, Sankhla SK, Agrawal R: The enlarged translabyrinthine and transapical extension type I approach for large vestibular schwannomas. Indian J Otolaryngol Head Neck Surg; 2010 Oct;62(4):360-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The enlarged translabyrinthine and transapical extension type I approach for large vestibular schwannomas.
  • To evaluate the results obtained by performing the enlarged translabyrinthine and transapical extension type I approaches for removal of large vestibular schwannomas and those with anterior extensions.
  • 35 patients of vestibular schwannomas having size greater than 3 cm in extrameatal diameter with extension anterior to the internal auditory canal who underwent the enlarged translabyrinthine or transapical extension type I approach and with a minimum follow up of 1 year are considered.
  • Tumor was removed completely in 34 subjects (97.1%).
  • Anatomic interruption of facial nerve occured in 4 cases (11.4%); 3 subjects underwent end to end anastomosis and 1 subject required a cable graft, these were done during the primary procedure itself.
  • Complete tumor removal with a very low morbidity in our series suggest that the enlarged translabyrinthine and transapical extension type I approach offers excellent control of the neurovascular structures in the cerebellopontine angle as also of the large vestibular schwannoma itself aiding complete removal.
  • It also offers the advantage of management of the interrupted facial nerve at the primary procedure itself since the proximal and distal segments are in the operative field.

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  • (PMID = 22319693.001).
  • [ISSN] 0973-7707
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3266084
  • [Keywords] NOTNLM ; Acoustic neuroma / Facial nerve / Translabyrinthine approach / Vestibular schwannoma
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59. Slattery WH 3rd: Microsurgery after radiosurgery or radiotherapy for vestibular schwannomas. Otolaryngol Clin North Am; 2009 Aug;42(4):707-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microsurgery after radiosurgery or radiotherapy for vestibular schwannomas.
  • Radiosurgery or radiotherapy for vestibular schwannomas has become a common practice with a high chance for tumor control.
  • Despite the high rate of tumor control, there are some tumors that cannot be controlled with radiation therapy.
  • Surgical treatment after radiosurgery or radiotherapy may be necessary for tumors that continue to grow, or for patients who develop brainstem compressive symptoms, disabling hemifacial spasm, or hydrocephalus.
  • The House Ear Clinic (Los Angeles, California) experience with microsurgery after irradiation has demonstrated that the facial nerve is different once it has been radiated.
  • An irradiated facial nerve's regeneration potential is diminished, and the recovery from microsurgical trauma is not as robust.
  • [MeSH-major] Microsurgery / methods. Neoplasm Invasiveness / pathology. Neuroma, Acoustic / radiotherapy. Neuroma, Acoustic / surgery. Radiosurgery / methods
  • [MeSH-minor] Combined Modality Therapy. Cranial Irradiation / methods. Dose-Response Relationship, Radiation. Female. Humans. Male. Neoadjuvant Therapy. Neoplasm Staging. Postoperative Complications / mortality. Postoperative Complications / physiopathology. Prognosis. Radiotherapy Dosage. Radiotherapy, Conformal / methods. Risk Assessment. Survival Analysis. Treatment Outcome

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  • (PMID = 19751874.001).
  • [ISSN] 1557-8259
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 12
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60. Silk PS, Lane JI, Driscoll CL: Surgical approaches to vestibular schwannomas: what the radiologist needs to know. Radiographics; 2009 Nov;29(7):1955-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical approaches to vestibular schwannomas: what the radiologist needs to know.
  • Vestibular schwannomas account for 85% of cerebellopontine angle tumors in adults and most commonly arise from the inferior division of the vestibular nerve.
  • Three main surgical techniques are currently being used for the removal of vestibular schwannomas: middle cranial fossa, suboccipital, and translabyrinthine approaches.
  • A good understanding of the main surgical approaches, relevant anatomic considerations, surgical complications, and likelihood of tumor recurrence is essential for interpreting magnetic resonance images to the advantage of both the surgeon and the patient, particularly when hearing preservation is a consideration.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Neuroma, Acoustic / diagnosis. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods. Surgery, Computer-Assisted / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 19926756.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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61. Kondziolka D, Lunsford LD: Future perspectives in acoustic neuroma management. Prog Neurol Surg; 2008;21:247-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Future perspectives in acoustic neuroma management.
  • Management options for patients with vestibular schwannomas (acoustic neuromas) include observation, resection, stereotactic radiosurgery, or fractionated radiotherapy.
  • There has been an evolution in available technologies, and an evolution in both patient and physician approaches to the management of this tumor.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / trends

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  • (PMID = 18810226.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 65
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62. Strauss C, Prell J, Rampp S, Romstöck J: Split facial nerve course in vestibular schwannomas. J Neurosurg; 2006 Nov;105(5):698-705
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Split facial nerve course in vestibular schwannomas.
  • OBJECT: The facial nerve in vestibular schwannomas (VSs) is located on the ventral tumor surface in more than 90% of cases; other courses are rare.
  • A split facial nerve course with two distinct bundles has thus far been described exclusively for medial extrameatal tumors.
  • METHODS: Between 1996 and 2005, 16 consecutive cases of 241 surgically treated VSs were observed to have distinct splitting of the facial nerve.
  • The mean tumor size measured 27 mm.
  • In one third of the cases, intrameatal tumor extension with obliteration of the fundus was documented.
  • In all 16 patients, distinct splitting of the facial nerve was demonstrated.
  • The major portion of the facial nerve followed a typical course on the ventral tumor surface.
  • The smaller nerve portion in all cases ran parallel to the brainstem up to the level of the trigeminal root exit zone and crossed on the cranial tumor pole to the internal auditory canal.
  • The two nerve portions rejoined at the level of the porus acusticus.
  • The smaller portion carried fibers exclusively to the orbicularis oris muscle, whereas the major portion supplied all three branches of the facial nerve.
  • CONCLUSIONS: In VSs, an aberrant course with distinct splitting of the facial nerve adds considerably to the surgical challenge.
  • Long-term facial nerve results are excellent with extensive neurophysiological monitoring, which allows the differentiation and identification of aberrant facial nerve fibers and avoids additional risks to facial nerve preservation.
  • [MeSH-major] Facial Nerve / pathology. Facial Nerve / physiopathology. Neuroma, Acoustic / pathology. Neuroma, Acoustic / physiopathology
  • [MeSH-minor] Adult. Aged. Cochlear Nerve / physiopathology. Cohort Studies. Electromyography. Facial Muscles / physiopathology. Female. Humans. Male. Middle Aged. Monitoring, Intraoperative. Treatment Outcome

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  • (PMID = 17121130.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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63. Jain VK, Mehrotra N, Sahu RN, Behari S, Banerji D, Chhabra DK: Surgery of vestibular schwannomas: an institutional experience. Neurol India; 2005 Mar;53(1):41-5; discussion 45
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  • [Title] Surgery of vestibular schwannomas: an institutional experience.
  • AIMS: To report management results of vestibular schwannomas (VS) treated surgically in our institute, with particular reference to completeness of tumor excision, facial nerve and hearing preservation and complications of surgery.
  • MATERIALS AND METHODS: The facial nerve function and hearing assessment was done according to House-Brackmann [HB] grading and pure tone audiometry (PTA) respectively.
  • RESULTS: Most patients had large tumors and had no useful hearing (90%), had disabling cerebellar ataxia (88%) and presented with features of raised intra-cranial pressure (45%).
  • Large sized tumors were in 41.3% and giant sized tumors were in 56% cases.
  • Complete tumor excision was carried out in 96.5% and anatomical preservation of facial nerve was achieved in 79.2% cases.
  • Cerebrospinal fluid leak with or without meningitis and transient lower cranial nerve paresis were common complications.
  • CONCLUSIONS: With experience, complete tumor excision with good facial nerve preservation can be achieved in large tumors.
  • Hearing preservation is difficult in bigger tumors.
  • [MeSH-major] Facial Nerve / physiology. Neuroma, Acoustic / surgery. Neurosurgical Procedures / methods. Postoperative Complications

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  • (PMID = 15805654.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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64. Lunsford LD, Niranjan A, Flickinger JC, Maitz A, Kondziolka D: Radiosurgery of vestibular schwannomas: summary of experience in 829 cases. J Neurosurg; 2005 Jan;102 Suppl:195-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiosurgery of vestibular schwannomas: summary of experience in 829 cases.
  • OBJECT: Management options for vestibular schwannomas (VSs) have greatly expanded since the introduction of stereotactic radiosurgery.
  • Optimal outcomes reflect long-term tumor control, preservation of cranial nerve function, and retention of quality of life.
  • The average tumor volume was 2.5 cm3.
  • The median margin dose to the tumor was 13 Gy (range 10-20 Gy).
  • Unchanged hearing preservation was possible in 50 to 77% of patients (up to 90% in those with intracanalicular tumors).
  • Trigeminal symptoms were detected in less than 3% of patients whose tumors reached the level of the trigeminal nerve.
  • Tumor control rates at 10 years were 97% (no additional treatment needed).
  • Gamma knife surgery provides a low risk, minimally invasive treatment option for patients with newly diagnosed or residual vs. Cranial nerve preservation and quality of life maintenance are possible in long-term follow up.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / instrumentation
  • [MeSH-minor] Female. Follow-Up Studies. Hearing Disorders / diagnosis. Hearing Disorders / etiology. Humans. Magnetic Resonance Imaging. Male. Neoplasm Staging. Radiation Dosage. Severity of Illness Index. Trigeminal Neuralgia / etiology. Tumor Burden / radiation effects

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  • (PMID = 15662809.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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65. Fukuoka S, Takanashi M, Hojyo A, Konishi M, Tanaka C, Nakamura H: Gamma knife radiosurgery for vestibular schwannomas. Prog Neurol Surg; 2009;22:45-62
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  • [Title] Gamma knife radiosurgery for vestibular schwannomas.
  • The purpose of this study was to analyze tumor control and possible complications of gamma knife radiosurgery (GKRS) in patients with vestibular schwannomas using low marginal doses and conformal multiple shots to fit irregular tumor shapes.
  • The actuarial tumor control rates were 94% at 5 years and 92.4% at 8 years.
  • Larger tumors (p < 0.0001) and those in younger patients (p = 0.018) tended to recur significantly more often.
  • Fifty-six other patients not included in the long-term evaluation consecutively underwent caloric testing and static stabilometry as well as neurological examinations to evaluate vestibular function in detail, both before and after GKRS.
  • The results revealed 90% of the patients to have already developed vestibular dysfunction prior to the treatment despite reported symptoms of dizziness.
  • GKRS did not significantly affect vestibular function.
  • Hydrocephalus was recognized in 5.3% of all patients, and tended to occur in cases with larger tumors (p = 0.0024).
  • GKRS provides a safe and effective therapy for small to medium-sized tumors.
  • However, indications for larger tumors must be carefully considered, as they are more difficult to control and liable to produce ataxia due to transient expansion.
  • [MeSH-major] Hearing. Neuroma, Acoustic / surgery. Radiosurgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Facial Nerve / physiology. Female. Follow-Up Studies. Humans. Hydrocephalus / diagnosis. Magnetic Resonance Imaging. Male. Middle Aged. Postoperative Complications / diagnosis. Radiation Dosage. Tomography, Emission-Computed, Single-Photon. Treatment Outcome. Trigeminal Nerve / physiology. Vestibular Nerve / physiology. Young Adult

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  • (PMID = 18948719.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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66. Lassaletta L, Patrón M, Del Río L, Alfonso C, Roda JM, Rey JA, Gavilan J: Cyclin D1 expression and histopathologic features in vestibular schwannomas. Otol Neurotol; 2007 Oct;28(7):939-41
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  • [Title] Cyclin D1 expression and histopathologic features in vestibular schwannomas.
  • OBJECTIVE: To evaluate cyclin D1 expression in vestibular schwannoma and its relationship with histologic, clinical, and radiologic features.
  • PATIENTS: Twenty-one patients with histologically confirmed vestibular schwannoma.
  • Cyclin D1 expression was more frequent in right-sided tumors (p = 0.02) and in tumors with nuclear degenerative changes (p < 0.0001).
  • CONCLUSION: Cyclin D1 expression, present in nearly half of the cases, may play a role in the development of these tumors.
  • Further studies are needed to fully understand the contributions of histopathologic and immunohistochemical factors to vestibular schwannoma biological activity.
  • [MeSH-major] Cranial Nerve Neoplasms / genetics. Cranial Nerve Neoplasms / pathology. Gene Expression Regulation, Neoplastic / genetics. Genes, bcl-1 / genetics. Neuroma, Acoustic / genetics. Neuroma, Acoustic / pathology. Vestibulocochlear Nerve Diseases / genetics. Vestibulocochlear Nerve Diseases / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Audiometry. Deafness / etiology. Female. Hearing Loss / etiology. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Middle Aged. Paraffin Embedding. Vestibular Nuclei / pathology

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  • (PMID = 17704717.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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67. Roche PH, Pellet W, Moriyama T, Thomassin JM: Translabyrinthine approach for vestibular schwannomas: operative technique. Prog Neurol Surg; 2008;21:73-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Translabyrinthine approach for vestibular schwannomas: operative technique.
  • For large vestibular schwannomas (VSs) for which removal is the primary therapy, the goals are complete tumor resection and maintenance of normal neurological function.
  • The authors analyzed their results about facial nerve preservation, extent of resection and complications following resection of large VSs via a widened translabyrinthine approach.
  • One percent of meningitis, 1% of posterior fossa hematoma and 4% of transient lower cranial nerve palsies were observed.
  • Total tumor removal was achieved in 85% of cases, near-total in 11% and subtotal in 4% of cases.
  • [MeSH-major] Ear, Inner / surgery. Neuroma, Acoustic / surgery. Neurosurgical Procedures / methods

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  • (PMID = 18810201.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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68. Friedman WA, Bradshaw P, Myers A, Bova FJ: Linear accelerator radiosurgery for vestibular schwannomas. J Neurosurg; 2006 Nov;105(5):657-61
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  • [Title] Linear accelerator radiosurgery for vestibular schwannomas.
  • OBJECT: Radiosurgery has become a popular treatment for small vestibular schwannomas (VSs).
  • Multivariate and actuarial statistics were used to analyze rates of local tumor control and complications, including facial and trigeminal neuropathies, after treatment.
  • Only four patients (1%) required surgery for tumor growth.
  • The risk of these complications rose with increasing tumor volume or increasing radiosurgical dose to the tumor periphery.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery

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  • [CommentIn] J Neurosurg. 2006 Nov;105(5):655-6; discussion 656 [17121122.001]
  • (PMID = 17121123.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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69. Neff BA, Welling DB, Akhmametyeva E, Chang LS: The molecular biology of vestibular schwannomas: dissecting the pathogenic process at the molecular level. Otol Neurotol; 2006 Feb;27(2):197-208
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The molecular biology of vestibular schwannomas: dissecting the pathogenic process at the molecular level.
  • OBJECTIVE: The goal of this article was to review concisely what is currently known about the tumorigenesis of vestibular schwannomas.
  • BACKGROUND: Recent advances in molecular biology have led to a better understanding of the cause of vestibular schwannomas.
  • Mutations in the neurofibromatosis type 2 tumor suppressor gene (NF2) have been identified in these tumors.
  • In addition, the interactions of merlin, the protein product of the NF2 gene, and other cellular proteins are beginning to give us a better idea of NF2 function and the pathogenesis of vestibular schwannomas.
  • RESULTS: The clinical characteristics of vestibular schwannomas and neurofibromatosis type 2 syndromes are reviewed and related to alterations in the NF2 gene.
  • Studies demonstrating our current understanding of tumor developmental pathways are highlighted.
  • In addition, methods of clinical and genetic screening for neurofibromatosis type 2 disease are outlined.
  • CONCLUSION: Great strides have been made to identify why vestibular schwannomas develop at the molecular level.
  • Continued research is needed to find targeted therapies with which to treat these tumors.
  • [MeSH-major] Chromosomes, Human, Pair 22. Genes, Neurofibromatosis 2. Mutation. Neurofibromin 2 / genetics. Neuroma, Acoustic / genetics
  • [MeSH-minor] Alternative Splicing. Animals. Disease Models, Animal. Genetic Testing. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Mice. Promoter Regions, Genetic. RNA, Messenger / genetics. Signal Transduction / genetics

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  • (PMID = 16436990.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neurofibromin 2; 0 / RNA, Messenger
  • [Number-of-references] 114
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70. Roche PH, Khalil M, Soumare O, Régis J: Hydrocephalus and vestibular schwannomas: considerations about the impact of gamma knife radiosurgery. Prog Neurol Surg; 2008;21:200-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hydrocephalus and vestibular schwannomas: considerations about the impact of gamma knife radiosurgery.
  • Hydrocephalus may occur at various stages of the natural course of vestibular schwannoma and can also be diagnosed after the therapeutic procedure.
  • The aim of the present study was to analyze the impact of Gamma Knife radiosurgery (GKR) on previously diagnosed hydrocephalus (group A patients) and to evaluate the incidence of de novo hydrocephalus after GKR (group B patients).
  • Among the first 1,000 vestibular schwannoma patients treated by GKR in our institution, 30 patients (3%) belonged to group A and 1% to group B.
  • In both groups, hydrocephalus was more often associated with the following data: Elderly, large tumor, previous MS, NF2 disease and bilateral tumors.
  • De novo post-GKR hydrocephalus is of low incidence, comparable to the postoperative rate.
  • [MeSH-major] Hydrocephalus / epidemiology. Neuroma, Acoustic / surgery. Radiosurgery

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  • (PMID = 18810220.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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71. Thomas C, Di Maio S, Ma R, Vollans E, Chu C, Clark B, Lee R, McKenzie M, Martin M, Toyota B: Hearing preservation following fractionated stereotactic radiotherapy for vestibular schwannomas: prognostic implications of cochlear dose. J Neurosurg; 2007 Nov;107(5):917-26
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  • [Title] Hearing preservation following fractionated stereotactic radiotherapy for vestibular schwannomas: prognostic implications of cochlear dose.
  • OBJECT: The goal in this study was to evaluate hearing preservation rates and to determine prognostic factors for this outcome following fractionated stereotactic radiotherapy (FSRT) of vestibular schwannoma.
  • Permanent trigeminal and facial nerve complications were 0 and 6%, respectively.
  • Radiotherapy dose to the cochlear nucleus, patient age, sex, pre-FSRT hearing grade, tumor volume, and intracanalicular tumor volume failed to show any significance as prognostic factors.
  • [MeSH-major] Cochlea / radiation effects. Hearing. Neuroma, Acoustic / radiotherapy. Radiosurgery
  • [MeSH-minor] Adolescent. Adult. Aged. Facial Nerve / physiology. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prognosis. Prospective Studies. Radiation Dosage. Trigeminal Nerve / physiology

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  • (PMID = 17977261.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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72. Roche PH, Ribeiro T, Fournier HD, Thomassin JM: Vestibular schwannomas: complications of microsurgery. Prog Neurol Surg; 2008;21:214-21
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  • [Title] Vestibular schwannomas: complications of microsurgery.
  • Current microsurgical treatment of vestibular schwannomas usually brings satisfactory results for the patients.
  • However, transient or permanent complications may occur, especially when treating large tumors.
  • Based on their personal experience of large operated vestibular schwannomas and analyzing a review of the international literature, the authors detail these complications and the way to prevent and manage them.
  • Lower cranial nerve deficits are unusual but may expose to early and delayed aspiration pneumonias.
  • [MeSH-major] Microsurgery / adverse effects. Neuroma, Acoustic / surgery
  • [MeSH-minor] Cerebrovascular Disorders / etiology. Cranial Nerve Diseases / etiology. Craniotomy / adverse effects. Humans. Meningitis / etiology

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  • (PMID = 18810222.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 18
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73. Lagerwaard FJ, Meijer OW, van der Hoorn EA, Verbakel WF, Slotman BJ, Senan S: Volumetric modulated arc radiotherapy for vestibular schwannomas. Int J Radiat Oncol Biol Phys; 2009 Jun 1;74(2):610-5
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  • [Title] Volumetric modulated arc radiotherapy for vestibular schwannomas.
  • PURPOSE: To evaluate volumetric modulated arc radiotherapy (RapidArc [RA]), a novel approach allowing for rapid treatment delivery, for the treatment of vestibular schwannoma (VS).
  • A superior CI was achieved with RA, with a substantial decrease in low-dose irradiation of the normal brain achieved relative to 5DCA plans.
  • [MeSH-major] Neuroma, Acoustic / radiotherapy. Radiotherapy Planning, Computer-Assisted / methods. Radiotherapy, Intensity-Modulated / methods
  • [MeSH-minor] Algorithms. Humans. Neoplasms, Radiation-Induced / prevention & control. Neoplasms, Second Primary / prevention & control. Phantoms, Imaging. Radiosurgery. Radiotherapy Dosage. Trigeminal Nerve / radiation effects. Tumor Burden

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  • (PMID = 19427560.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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74. Akard W, Tubbs RS, Seymour ZA, Hitselberger WE, Cohen-Gadol AA: Evolution of techniques for the resection of vestibular schwannomas: from saving life to saving function. J Neurosurg; 2009 Apr;110(4):642-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evolution of techniques for the resection of vestibular schwannomas: from saving life to saving function.
  • The current state of surgery for vestibular schwannomas (VSs) is the result of a century of step-by-step technical progress by groundbreaking surgeons who transformed the procedure from its hazardous infancy and high mortality rate to its current state of safety and low morbidity rate.
  • Harvey Cushing advocated bilateral suboccipital decompression and developed the method of intracapsular tumor enucleation.
  • Walter Dandy supported the unilateral suboccipital approach and developed the technique of gross-total tumor resection.
  • The authors examined the Cushing Brain Tumor Registry for clues regarding the bona fide intention of Cushing for the resection of these tumors.
  • [MeSH-major] Neuroma, Acoustic / history. Neurosurgical Procedures / history

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  • (PMID = 18991500.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article
  • [Publication-country] United States
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75. Diallo BK, Franco-Vidal V, Vasili D, Négrevergne M, Darrouzet P, Diouf R, Darrouzet V: [The neurotologic evaluation of vestibular schwannomas. Results of audiological and vestibular testing in 100 consecutive cases]. Rev Laryngol Otol Rhinol (Bord); 2006;127(4):203-9
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  • [Title] [The neurotologic evaluation of vestibular schwannomas. Results of audiological and vestibular testing in 100 consecutive cases].
  • [Transliterated title] L' evaluation neurotologique audio-vestibulaire des schwannomes vestibulaires. A propos de 100 cas.
  • OBJECTIVES: To determine the results and sensitivity of a comprehensive audiological and vestibular work-up in patients presenting with vestibular schwannoma (VS).
  • A comprehensive work-up was conducted in all patients, including pure tone and speech audiometry, Brainstem Evoked Audiologic Potentials (BEAP) assessment, Vestibular Evoked Myogenic Potentials (VEMP) examination and bithermal caloric testing using videonystagmography, on both sides.
  • [MeSH-major] Hearing Loss, Sensorineural / diagnosis. Hearing Loss, Sensorineural / etiology. Neuroma, Acoustic / complications. Neuroma, Acoustic / pathology

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  • (PMID = 17315783.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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76. Wickremesekera A, Hovens CM, Kaye AH: Expression of ErbB-1 and 2 in vestibular schwannomas. J Clin Neurosci; 2007 Dec;14(12):1199-206
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  • [Title] Expression of ErbB-1 and 2 in vestibular schwannomas.
  • Using immunohistochemistry and Western blot techniques we have shown an increased expression of ErbB-2 and no expression of ErbB-1 in vestibular schwannomas (VS).
  • [MeSH-major] Cranial Nerve Neoplasms / metabolism. Neuroma, Acoustic / metabolism. Receptor, Epidermal Growth Factor / biosynthesis. Receptor, ErbB-2 / biosynthesis
  • [MeSH-minor] Animals. Blotting, Western. Brain Neoplasms / metabolism. Brain Neoplasms / pathology. Cells, Cultured. Glioblastoma / metabolism. Glioblastoma / pathology. Humans. Immunohistochemistry. Immunoprecipitation. Mice. Neoplasm Proteins / chemistry. Neoplasm Proteins / isolation & purification

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  • (PMID = 17964790.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Neoplasm Proteins; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2
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77. Ciric I, Zhao JC, Rosenblatt S, Wiet R, O'Shaughnessy B: Suboccipital retrosigmoid approach for removal of vestibular schwannomas: facial nerve function and hearing preservation. Neurosurgery; 2005 Mar;56(3):560-70; discussion 560-70
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  • [Title] Suboccipital retrosigmoid approach for removal of vestibular schwannomas: facial nerve function and hearing preservation.
  • In this report, we discuss the pertinent bony, arachnoid, and neurovascular anatomy of vestibular schwannomas that has an impact on the surgical technique for removal of these tumors, with the goal of facial nerve and hearing preservation.
  • The surgical technique is described in detail starting with anesthesia, positioning, and neurophysiological monitoring and continuing with the exposure, technical nuances of tumor removal, hemostasis, and closure.
  • [MeSH-major] Facial Nerve Injuries / prevention & control. Hearing Loss, Sensorineural / prevention & control. Neuroma, Acoustic / surgery. Postoperative Complications / prevention & control
  • [MeSH-minor] Anesthesia, General. Arachnoid / anatomy & histology. Cochlear Nerve / anatomy & histology. Dura Mater / surgery. Electromyography. Endolymphatic Duct / anatomy & histology. Evoked Potentials, Auditory, Brain Stem. Facial Nerve / anatomy & histology. Humans. Mastoid / anatomy & histology. Monitoring, Intraoperative. Neurosurgical Procedures / methods. Prognosis. Semicircular Canals / anatomy & histology

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  • (PMID = 15730582.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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78. Fuentes S, Arkha Y, Pech-Gourg G, Grisoli F, Dufour H, Régis J: Management of large vestibular schwannomas by combined surgical resection and gamma knife radiosurgery. Prog Neurol Surg; 2008;21:79-82
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  • [Title] Management of large vestibular schwannomas by combined surgical resection and gamma knife radiosurgery.
  • In this report, we evaluated the treatment results of a combination of surgery and radiosurgery for large vestibular schwannomas.
  • The series of 8 patients included in this study underwent surgery followed by radiosurgical treatment between January 2000 and January 2006.
  • The average maximum diameter of the tumor was 40 (35-45) mm.
  • The mean peripheral dose administered was 11.8 (range 11-13) Gy, and the mean dose administered in the centre of the tumor was 23.75 (22-26) Gy.
  • Excellent facial nerve function (House-Brackmann grade 1 or 2) was preserved in 7/8 patients (87.5%).
  • In the case of large vestibular schwannomas, the combined management is one option for maintaining cranial nerve function and tumor growth control.
  • [MeSH-major] Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Radiosurgery
  • [MeSH-minor] Adult. Aged. Cohort Studies. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm, Residual. Radiotherapy Dosage. Retrospective Studies. Treatment Outcome

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  • (PMID = 18810202.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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79. Ferri GG, Modugno GC, Calbucci F, Ceroni AR, Pirodda A: Hearing loss in vestibular schwannomas: analysis of cochlear function by means of distortion-product otoacoustic emissions. Auris Nasus Larynx; 2009 Dec;36(6):644-8
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  • [Title] Hearing loss in vestibular schwannomas: analysis of cochlear function by means of distortion-product otoacoustic emissions.
  • OBJECTIVE: We investigated cochlear function in a group of patients affected by vestibular schwannoma (VS), by means of recording distortion-product otoacoustic emissions (DPOAEs).
  • We also related the responses to some clinical variables (tumor size, intracanalicular tumor and radiologic appearance of the internal auditory canal).
  • In eight cases we detected acoustic responses despite a profound hearing loss.
  • DPOAEs still remain just a complementary auditory test; nevertheless, in case of severe or profound unilateral hearing loss, recorded acoustic responses may be suspicious for the presence of a vestibular schwannoma.
  • [MeSH-major] Cochlea / physiopathology. Hearing Loss, Sensorineural / physiopathology. Neuroma, Acoustic / physiopathology. Otoacoustic Emissions, Spontaneous / physiology

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  • (PMID = 19419826.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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80. Wackym PA, Hannley MT, Runge-Samuelson CL, Jensen J, Zhu YR: Gamma Knife surgery of vestibular schwannomas: longitudinal changes in vestibular function and measurement of the Dizziness Handicap Inventory. J Neurosurg; 2008 Dec;109 Suppl:137-43
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  • [Title] Gamma Knife surgery of vestibular schwannomas: longitudinal changes in vestibular function and measurement of the Dizziness Handicap Inventory.
  • OBJECT: Gamma Knife surgery (GKS) is one of the methods available to treat vestibular schwannomas (VSs), in addition to microsurgical resection; however, clear information regarding balance function outcomes and the impact of treatment on patients' quality of life over time remains an important clinical need.
  • METHODS: This was a prospective clinical study of balance outcomes in all patients with VSs treated in the Acoustic Neuroma and Skull Base Surgery Program at a tertiary referral center by the senior author and the Gamma Knife team between June 2000 and May 2008.
  • The main outcome measures included preoperative vestibular testing and postoperative caloric testing performed at 6-month intervals to determine vestibular function.
  • Various patterns of changes in vestibular function were observed in either positive or negative directions.
  • CONCLUSIONS: Longitudinal changes in vestibular function occur over time, with the largest changes seen in the first 6 months after treatment.
  • Potential for clinical intervention, such as vestibular rehabilitation therapy, exists during this interval; however, larger cohorts must be studied to determine the timing and efficacy of this intervention.
  • [MeSH-major] Neuroma, Acoustic / physiopathology. Neuroma, Acoustic / surgery. Radiosurgery. Vestibule, Labyrinth / physiopathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cohort Studies. Dizziness / etiology. Dizziness / physiopathology. Dizziness / prevention & control. Female. Humans. Male. Middle Aged. Postural Balance / physiology. Quality of Life. Retrospective Studies. Time Factors. Treatment Outcome. Vestibular Function Tests

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  • (PMID = 19123900.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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81. Liscak R, Vladyka V, Urgosik D, Simonova G, Vymazal J: Repeated treatment of vestibular schwannomas after gamma knife radiosurgery. Acta Neurochir (Wien); 2009 Apr;151(4):317-24; discussion 324
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  • [Title] Repeated treatment of vestibular schwannomas after gamma knife radiosurgery.
  • The results and risks of repeat treatment of patients with a vestibular schwannoma were reviewed to assess its efficacy and safety.
  • METHODS: Between 1992 and 2001, we treated 351 patients with a vestibular schwannoma by GKS, control of the growth of the tumour was not achieved in 32.
  • CONCLUSIONS: In the small proportion of patients (9%) in whom initial GKS does not control the growth of a vestibular schwannoma, most can be controlled by further GKS with a very low risk of a complications.
  • [MeSH-major] Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Postoperative Complications / epidemiology. Radiosurgery / adverse effects. Radiosurgery / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Facial Nerve Injuries / epidemiology. Female. Hearing Loss, Sensorineural / epidemiology. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / surgery. Neurosurgical Procedures / statistics & numerical data. Reoperation / adverse effects. Reoperation / statistics & numerical data. Risk Assessment. Vestibular Nerve / pathology. Vestibular Nerve / surgery. Young Adult

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  • (PMID = 19277457.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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82. Gerganov V, Nouri M, Stieglitz L, Giordano M, Samii M, Samii A: Radiological factors related to pre-operative hearing levels in patients with vestibular schwannomas. J Clin Neurosci; 2009 Aug;16(8):1009-12
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  • [Title] Radiological factors related to pre-operative hearing levels in patients with vestibular schwannomas.
  • The pathogenetic mechanism of hearing loss in patients with vestibular schwannomas (VS) remains unclear.
  • Image processing software was used to analyse the maximal tumor diameter in three planes; its volume; its extension cranially, caudally, anteriorly and posteriorly; the width and length of the intrameatal tumor portion, its shape and consistency; and the tumor-fundus distance.
  • The degree of hearing correlated significantly with the tumor size, volume and coronal diameter, the degree of intrameatal tumor growth, and the distance between the lateral tumor end and the fundus (p < 0.05).
  • No correlation was found regarding tumor extension, shape and consistency, the presence of hydrocephalus, or the extent of erosion of the internal auditory canal.
  • [MeSH-major] Cranial Nerve Neoplasms / pathology. Hearing. Neuroma, Acoustic / pathology
  • [MeSH-minor] Adult. Aging. Ear Canal / pathology. Female. Hearing Tests. Humans. Hydrocephalus / pathology. Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Male. Middle Aged. Vestibulocochlear Nerve / pathology. Vestibulocochlear Nerve / surgery

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  • (PMID = 19428260.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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83. Chan AW, Black P, Ojemann RG, Barker FG 2nd, Kooy HM, Lopes VV, McKenna MJ, Shrieve DC, Martuza RL, Loeffler JS: Stereotactic radiotherapy for vestibular schwannomas: favorable outcome with minimal toxicity. Neurosurgery; 2005 Jul;57(1):60-70; discussion 60-70
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  • [Title] Stereotactic radiotherapy for vestibular schwannomas: favorable outcome with minimal toxicity.
  • OBJECTIVE: To determine the outcome and toxicity in patients with vestibular schwannomas treated with conventionally fractionated stereotactic radiotherapy (SRT) and to identify prognostic factors that are predictive of outcome.
  • METHODS: Between 1992 and 2001, 70 patients with vestibular schwannomas were treated with linear accelerator-based SRT in our institutions.
  • The median tumor volume was 2.4 cm3 (range, 0.05-21.1 cm3).
  • The indications for SRT were distributed as follows: 47% newly diagnosed, 31% progressive tumors after watchful waiting, 3% adjuvant postoperative radiation, and 19% recurrent tumors after surgical resection.
  • RESULTS: Tumor recurrence was defined as progressive enlargement of tumor on follow-up magnetic resonance imaging studies.
  • One patient had a tumor recurrence at 38 months after SRT.
  • The actuarial tumor control rates were 100 and 98% at 3 and 5 years, respectively.
  • Three patients with a median tumor volume of 16.2 cm3 required surgical resection for persistent or increasing symptoms at a median of 37 months.
  • In multivariate analysis, tumor volume at time of treatment was predictive for neurosurgical intervention (surgical resection or shunt placement) after SRT (P = 0.001).
  • The 3- and 5-year actuarial rates of freedom from any neurosurgical intervention were 100 and 97% for patients with tumor volume less than 8 cm3 and 74 and 47% respectively for patients with tumor of at least 8 cm3 (P < 0.0001).
  • The 3-year actuarial rates of facial and trigeminal nerve preservation were 99 and 96%, respectively.
  • There was no difference in tumor control and cranial nerve function preservation rates seen in NF2 patients compared with non-NF2 patients.
  • Patients with large tumors are more likely to undergo neurosurgical interventions after SRT.
  • [MeSH-major] Dose Fractionation. Neuroma, Acoustic / surgery. Radiosurgery / methods. Stereotaxic Techniques. Treatment Outcome

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  • (PMID = 15987541.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] United States
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84. Dewan S, Norén G: Retreatment of vestibular schwannomas with Gamma Knife surgery. J Neurosurg; 2008 Dec;109 Suppl:144-8
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  • [Title] Retreatment of vestibular schwannomas with Gamma Knife surgery.
  • OBJECT: The response rate of vestibular schwannomas (VSs) to radiosurgery has reached the 97% level in several published series.
  • When failure rarely occurs, some controversy has existed as to whether the tumor has to be resected or can be safely retreated with radiosurgery.
  • Tumor control (size before and after the first and the second treatment) was evaluated using MR imaging to demonstrate the course after the 2 treatments.
  • Facial nerve function (House-Brackmann grading system), trigeminal nerve function, hearing (Gardner-Robertson classification), and any adverse radiation effects were evaluated.
  • One tumor remained unchanged over the first 6 months, but demonstrated signs of internal necrosis.
  • All patients demonstrated stable facial nerve function.
  • CONCLUSIONS: Vestibular schwannomas can be retreated with GKS with good tumor control response and low risk of toxicity.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery
  • [MeSH-minor] Aged. Facial Nerve / physiopathology. Female. Follow-Up Studies. Humans. Male. Middle Aged. Radiotherapy Dosage. Retreatment. Retrospective Studies. Treatment Outcome. Trigeminal Nerve / physiopathology. Tumor Burden

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  • (PMID = 19123901.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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85. Gerganov VM, Giordano M, Herold C, Samii A, Samii M: An electrophysiological study on the safety of the endoscope-assisted microsurgical removal of vestibular schwannomas. Eur J Surg Oncol; 2010 Apr;36(4):422-7
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  • [Title] An electrophysiological study on the safety of the endoscope-assisted microsurgical removal of vestibular schwannomas.
  • METHODS: We evaluated the risk of thermal or mechanical iatrogenic nerve injury related to endoscope application during microsurgical removal of vestibular schwannomas (VS) in a prospective group of 30 patients (Group A).
  • [MeSH-major] Endoscopy / methods. Microsurgery / methods. Neuroma, Acoustic / surgery

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  • [Copyright] Copyright (c) 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 19942394.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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86. MacNally SP, Rutherford SA, King AT, Freeman S, Thorne J, Mawman D, O'Driscoll MP, Evans DG, Ramsden RT: Outcome from surgery for vestibular schwannomas in children. Br J Neurosurg; 2009 Jun;23(3):226-31
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  • [Title] Outcome from surgery for vestibular schwannomas in children.
  • OBJECT: A review of sporadic and NF2-related vestibular schwannoma surgery in children (under 18 years of age) with a specific interest in resection rates, recurrence, facial nerve outcomes, hearing preservation, hearing rehabilitation and genetic analysis.
  • METHODS: A retrospective analysis of prospectively collected data of 35 consecutively operated vestibular schwannomas in 29 paediatric patients that underwent 38 operations between 1992 and 2007.
  • Pre- and post-operative radiology, facial nerve function, pure tone audiogram and speech discrimination tests were performed with a mean follow-up of 4.5 years.
  • The facial nerve was anatomically preserved in 92%.
  • Facial nerve function was excellent to good (Grades 1-3) in 88% with outcome related to tumour size.
  • Hearing rehabilitation can be successful by utilising cochlear implants and auditory brain stem implants (ABI) as appropriate.
  • [MeSH-major] Facial Nerve. Neurofibromatosis 2 / surgery. Neuroma, Acoustic / surgery
  • [MeSH-minor] Adolescent. Auditory Brain Stem Implants. Auditory Threshold / physiology. Child. Cochlear Implants. Codon, Nonsense / genetics. Cranial Nerve Neoplasms / surgery. Facial Nerve Diseases / surgery. Female. Hearing Disorders / prevention & control. Humans. Male. Neoplasm Recurrence, Local / pathology. Outcome Assessment (Health Care). Postoperative Complications / prevention & control. Postoperative Complications / rehabilitation. Prognosis. Retrospective Studies. Speech Discrimination Tests

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  • [CommentIn] Br J Neurosurg. 2009 Jun;23(3):232-3 [19533455.001]
  • (PMID = 19533454.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Codon, Nonsense
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87. Roche PH, Robitail S, Régis J: Two- and three dimensional measures of vestibular schwannomas and posterior fossa--implications for the treatment. Acta Neurochir (Wien); 2007 Mar;149(3):267-73; discussion 273
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  • [Title] Two- and three dimensional measures of vestibular schwannomas and posterior fossa--implications for the treatment.
  • BACKGROUND: There is no uniformly accepted method of reporting the size of vestibular schwannomas (VS) and to evaluate the individual tumour behaviour in the posterior fossa (PF).
  • Among several parameters, the T Diam was the best measure to assess the brain shift (ROC analysis) with a cut off value at 14.5 mm (91.7% sensitivity and 93% specificity).
  • VS volume and the ratio VS volume/PF volume were also efficient to predict a brain shift.
  • CONCLUSIONS: Max Diam and T Diam are bedside measured simple data of particular interest to respectively estimate the VS volume and predict the brain shift due to the tumour.
  • The determination of cut-off values correlated to brain shift will provide guidelines at the time of the therapeutic decision between radiosurgical and microsurgical strategy.
  • [MeSH-major] Image Processing, Computer-Assisted. Imaging, Three-Dimensional. Magnetic Resonance Imaging. Neuroma, Acoustic / diagnosis. Tomography, X-Ray Computed
  • [MeSH-minor] Adult. Aged. Cranial Fossa, Posterior / pathology. Dominance, Cerebral / physiology. Female. Humans. Male. Mathematical Computing. Microsurgery. Middle Aged. Neoplasm Staging. Organ Size. Prognosis. Radiosurgery. Software. Statistics as Topic

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  • (PMID = 17342379.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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88. Stankovic KM, Mrugala MM, Martuza RL, Silver M, Betensky RA, Nadol JB Jr, Stemmer-Rachamimov AO: Genetic determinants of hearing loss associated with vestibular schwannomas. Otol Neurotol; 2009 Aug;30(5):661-7
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  • [Title] Genetic determinants of hearing loss associated with vestibular schwannomas.
  • HYPOTHESIS: The severity of hearing loss (HL) associated with vestibular schwannomas (VSs) is influenced by genes expressed by the VSs.
  • Previous studies have suggested that VSs cause HL not only by inducing degeneration of the auditory nerve by compression but also by promoting degeneration of the inner ear.
  • Because of a small sample size, exact nonparametric tests were used to assess the association between good versus poor hearing and specific histological features of the tumors and patient demographics.
  • RESULTS: Using gene set enrichment analysis, the chromosomal region 3q27 was found to be significantly different between the 2 groups of tumors.
  • [MeSH-major] Genes, Neoplasm / genetics. Hearing Loss / etiology. Hearing Loss / genetics. Neuroma, Acoustic / complications. Neuroma, Acoustic / genetics

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  • (PMID = 19546833.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 63231-63-0 / RNA; 9007-49-2 / DNA
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89. Coelho DH, Roland JT Jr, Rush SA, Narayana A, St Clair E, Chung W, Golfinos JG: Small vestibular schwannomas with no hearing: comparison of functional outcomes in stereotactic radiosurgery and microsurgery. Laryngoscope; 2008 Nov;118(11):1909-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Small vestibular schwannomas with no hearing: comparison of functional outcomes in stereotactic radiosurgery and microsurgery.
  • OBJECTIVES: To date, numerous studies have compared functional outcomes between stereotactic radiosurgery (SRS) and microsurgery (MS) in the treatment of vestibular schwannomas (VS).
  • However, most of them involve tumors of difference sizes, radiation dosages, and surgical approaches.
  • By studying only patients with small tumors and no hearing, we sought to minimize confounding variables.
  • All MS patients underwent the translabyrinthine approach to their tumors.
  • Outcomes measurements included tumor control, facial nerve function, tinnitus, trigeminal function, and imbalance.
  • RESULTS: Patients undergoing SRS had comparable rates of tumor control, facial nerve function, tinnitus, and trigeminal function to MS patients.
  • CONCLUSIONS: In our study population, patients with small tumors and no serviceable hearing, these data suggest that MS results in comparable minimal morbidity with SRS, though posttreatment dysequilibrium is significantly decreased.
  • [MeSH-major] Facial Nerve / physiopathology. Hearing / physiology. Microsurgery / methods. Neuroma, Acoustic / physiopathology. Postural Balance / physiology. Radiosurgery / methods. Trigeminal Nerve / physiopathology

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  • (PMID = 18849856.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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90. Benech F, Perez R, Fontanella MM, Morra B, Albera R, Ducati A: Cystic versus solid vestibular schwannomas: a series of 80 grade III-IV patients. Neurosurg Rev; 2005 Jul;28(3):209-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cystic versus solid vestibular schwannomas: a series of 80 grade III-IV patients.
  • Cystic acoustic neuromas are less frequent than solid ones and present different clinical and radiological features.
  • Cystic schwannomas are larger, show a shorter clinical history and a different risk of postoperative complications.
  • This study was designed to compare surgical results and complications of solid and cystic vestibular schwannomas of matching size operated upon via either a retrosygmoid or a translabyrinthine approach.
  • The study included 80 patients presenting with grade III and IV acoustic vestibular schwannomas referred to the Neurosurgical and ENT team in the Department of Neuroscience of Torino, Italy.
  • In cystic tumors, rapid clinical worsening is common, due to sudden expansion of cystic elements.
  • Tighter adherences are found between cystic tumours and nervous elements (particularly brainstem and possibly facial nerve), once compared to solid ones.
  • Careful technique, possibly sharp dissection, to divide the tumour adherences from the nervous tissue must be employed, in order to avoid lesions on brainstem veins and traction on a thin facial nerve.
  • [MeSH-minor] Adult. Aged. Connective Tissue / pathology. Connective Tissue / surgery. Female. Humans. Immunohistochemistry. Male. Microsurgery. Middle Aged. Neoplasm Recurrence, Local. Pituitary Hormones / deficiency

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  • (PMID = 15739069.001).
  • [ISSN] 0344-5607
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Pituitary Hormones; 12629-01-5 / Human Growth Hormone
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91. Roche PH, Khalil M, Thomassin JM: Microsurgical removal of vestibular schwannomas after failed previous microsurgery. Prog Neurol Surg; 2008;21:158-62
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  • [Title] Microsurgical removal of vestibular schwannomas after failed previous microsurgery.
  • Recurrent and regrowing large vestibular schwannomas (VSs) may require another microsurgical procedure.
  • Additional surgery was justified by a large-sized growing tumor in main cases and/or occurrence of new symptoms.
  • Preservation of a good facial nerve motion (H-B gd I or II) was obtained in 3 out of the 6 cases who displayed this preoperative status.
  • Excluding the facial nerve injury, no major complication was observed in these cases.
  • Assuming that radiosurgery is an effective tool to control small- to middle-sized VSs, priority was recently given to the facial nerve preservation during the surgical removal of recurrent and regrowing VSs.
  • [MeSH-major] Microsurgery. Neoplasm Recurrence, Local / surgery. Neuroma, Acoustic / surgery
  • [MeSH-minor] Adult. Aged. Cohort Studies. Female. Humans. Male. Middle Aged. Neoplasm, Residual. Reoperation. Retrospective Studies. Treatment Failure. Tumor Burden

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  • (PMID = 18810214.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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92. Ambett R, Rupa V, Rajshekhar V: Analysis of causes for late presentation of Indian patients with vestibular schwannoma. J Laryngol Otol; 2009 May;123(5):502-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of causes for late presentation of Indian patients with vestibular schwannoma.
  • OBJECTIVE: To determine the causes of delay in diagnosis and treatment of Indian patients with vestibular schwannomas.
  • METHODS: In a prospective study from 2003 to 2005, 50 patients with a confirmed diagnosis of vestibular schwannoma were interviewed to determine the causes for (1) the delay between the patient noting the initial symptom and the definitive diagnosis, and (2) the reasons for delayed diagnosis.
  • After the patient had noted symptoms, the diagnosis of vestibular schwannoma was delayed due to doctor-related causes in 80 per cent of cases, and due to patient-related causes in 20 per cent.
  • CONCLUSIONS: Delay in the diagnosis of vestibular schwannoma in Indian patients is due to both doctor- and patient-related factors.
  • [MeSH-major] Hearing Loss, Sensorineural / etiology. Neuroma, Acoustic / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Disease Progression. Female. Health Knowledge, Attitudes, Practice. Humans. India. Male. Middle Aged. Prospective Studies. Referral and Consultation / standards. Time Factors. Tinnitus / etiology. Vertigo / etiology. Vestibular Function Tests. Young Adult

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  • (PMID = 18808730.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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93. Choy NL, Johnson N, Treleaven J, Jull G, Panizza B, Brown-Rothwell D: Balance, mobility and gaze stability deficits remain following surgical removal of vestibular schwannoma (acoustic neuroma): an observational study. Aust J Physiother; 2006;52(3):211-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Balance, mobility and gaze stability deficits remain following surgical removal of vestibular schwannoma (acoustic neuroma): an observational study.
  • QUESTION: Are there residual deficits in balance, mobility, and gaze stability after surgical removal of vestibular schwannoma?
  • PARTICIPANTS: Twelve people with a mean age of 52 years who had undergone surgical removal of vestibular schwannoma at least three months previously and had not undergone vestibular rehabilitation.
  • CONCLUSION: A prospective study is required to evaluate vestibular rehabilitation to ameliorate dizziness and to improve balance, mobility, and gaze stability for this clinical group.
  • [MeSH-major] Mobility Limitation. Neuroma, Acoustic / complications. Neuroma, Acoustic / surgery. Ocular Motility Disorders / etiology. Postural Balance. Sensation Disorders / etiology


94. Battista RA: Gamma knife radiosurgery for vestibular schwannoma. Otolaryngol Clin North Am; 2009 Aug;42(4):635-54
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  • [Title] Gamma knife radiosurgery for vestibular schwannoma.
  • Since Leksell first treated a patient who had a vestibular schwannoma in 1967, there has been a year-to-year increase in the number of patients treated with the gamma knife for vestibular schwannoma.
  • This article outlines the technique of GKRS and discusses the current results of its use to treat vestibular schwannomas.
  • Other topics discussed include tumor control, treatment of recurrent/residual and cystic vestibular schwannomas, and the results of treatment of neurofibromatosis type 2.
  • [MeSH-major] Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Radiation Injuries / prevention & control. Radiosurgery / methods
  • [MeSH-minor] Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Neoplasm Invasiveness / pathology. Neoplasm Staging. Patient Selection. Postoperative Complications / mortality. Postoperative Complications / physiopathology. Radiotherapy Dosage. Radiotherapy Planning, Computer-Assisted. Risk Assessment. Survival Analysis. Treatment Outcome

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  • (PMID = 19751869.001).
  • [ISSN] 1557-8259
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 62
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95. Mautner VF, Nguyen R, Kutta H, Fuensterer C, Bokemeyer C, Hagel C, Friedrich RE, Panse J: Bevacizumab induces regression of vestibular schwannomas in patients with neurofibromatosis type 2. Neuro Oncol; 2010 Jan;12(1):14-8
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  • [Title] Bevacizumab induces regression of vestibular schwannomas in patients with neurofibromatosis type 2.
  • Bilateral vestibular schwannomas are the hallmark of neurofibromatosis type 2 (NF2), and these tumors impair hearing and frequently lead to deafness.
  • Neurosurgical intervention, the only established treatment, often damages the vestibular nerve.
  • We report 2 cases in which treatment with bevacizumab (for 3 months in one case and 6 months in the other) induced regression of progressive vestibular schwannomas by more than 40% and substantially improved hearing in the patient treated for 6 months.
  • Bevacizumab therapy may thus provide an effective treatment for progressive vestibular schwannomas in patients with NF2.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Antineoplastic Agents / therapeutic use. Neurofibromatosis 2 / drug therapy. Neuroma, Acoustic / drug therapy

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  • [Cites] J Neurosurg. 2002 Jun;96(6):1063-71 [12066908.001]
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  • (PMID = 20150363.001).
  • [ISSN] 1523-5866
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; 2S9ZZM9Q9V / Bevacizumab
  • [Other-IDs] NLM/ PMC2940556
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96. Kabil MS, Shahinian HK: A series of 112 fully endoscopic resections of vestibular schwannomas. Minim Invasive Neurosurg; 2006 Dec;49(6):362-8
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  • [Title] A series of 112 fully endoscopic resections of vestibular schwannomas.
  • We report a consecutive series of 112 patients with unilateral vestibular schwannoma (VS) having undergone fully endoscopic resection of their tumors in the period from October, 2001 to January, 2005.
  • Patients' outcomes were evaluated especially with regards to cochlear nerve (hearing) preservation, facial nerve preservation, postoperative complications and completeness of the resection.
  • The patient population consisted of 112 consecutive cases with unilateral, "de novo" VS(s); patients with neurofibromatosis type 2 (NFT2) or with a recurrent tumor were excluded from this study.
  • Tumors ranged in size from 0.6-5.7 cm, most tumors were less than 3 cm in diameter (mean: 2.6 cm).
  • This shift towards smaller and also less symptomatic tumors may be due to an increase in the awareness of patients and earlier detection of their tumors (MRI era).
  • Tumors were removed via 1.5-cm "keyhole" retrosigmoid craniotomies.
  • Utilizing the fully endoscopic technique, 106/112 (95%) tumors were completely removed; subtotal removal was performed in 6/112 (5%) patients in an attempt to preserve their hearing.
  • Anatomic preservation of the facial nerve was achieved in all of the patients and of the cochlear nerve in 83/101 (82%) hearing ears.
  • There were no major neurological complications such as quadriparesis, hemiparesis, bacterial or aseptic meningitis, lower cranial nerve deficits, or deaths.
  • From our experience, we conclude that the endoscope is ideally suited for a minimally invasive approach for the resection of vestibular schwannomas.
  • [MeSH-major] Endoscopy. Neuroma, Acoustic / surgery

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  • (PMID = 17323265.001).
  • [ISSN] 0946-7211
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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97. Schaller BJ, Rasper J, Filis A, Buchfelder M: Difference in functional outcome of ipsilateral tinnitus after intraoperative occurrence of the trigemino-cardiac reflex in surgery for vestibular schwannomas. Acta Neurochir (Wien); 2008 Feb;150(2):157-60
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  • [Title] Difference in functional outcome of ipsilateral tinnitus after intraoperative occurrence of the trigemino-cardiac reflex in surgery for vestibular schwannomas.
  • OBJECT: Surgical manipulation of the fifth cranial nerve in its intra- or extracranial course may lead to bradycardia or even asystole as well as arterial hypotension, a phenomenon described as the trigemino-cardiac reflex (TCR), first described by the authors previously [11].
  • The authors report here the impact of this reflex on post-operative ipsilateral tinnitus in patients undergoing vestibular schwannoma surgery.
  • METHODS: Thirty six patients scheduled for vestibular schwannoma surgery were studied retrospectively for parameters influencing the post-operative ipsilateral tinnitus function.
  • RESULTS: The TCR occurred in 17% of the patients during vestibular schwannoma surgery and influenced the occurrence of post-operative ipsilateral tinnitus: the overall incidence of post-operative ipsilateral tinnitus was 22%.
  • CONCLUSION: Hypotension after intra-operative TCR is not only a negative prognostic factor for hearing preservation but also for ipsilateral tinnitus in patients undergoing vestibular schwannoma surgery.
  • In combination with worse hearing function after intra-operative TCR, the present finding underlines the importance of the TCR during skull base surgery in relation to improved functional outcome.
  • [MeSH-major] Neuroma, Acoustic / surgery. Postoperative Complications. Reflex / physiology. Tinnitus / etiology

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  • (PMID = 18080085.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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98. Tamura M, Carron R, Yomo S, Arkha Y, Muraciolle X, Porcheron D, Thomassin JM, Roche PH, Régis J: Hearing preservation after gamma knife radiosurgery for vestibular schwannomas presenting with high-level hearing. Neurosurgery; 2009 Feb;64(2):289-96; discussion 296
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hearing preservation after gamma knife radiosurgery for vestibular schwannomas presenting with high-level hearing.
  • OBJECTIVE: The aim of this study was to evaluate long-term hearing preservation after gamma knife radiosurgery (GKS) for vestibular schwannomas in patients with initially normal or subnormal hearing (Gardner-Robertson Class 1) and to determine the predictive factors for functional hearing preservation.
  • METHODS: Since July 1992, more than 2053 vestibular schwannomas have been treated by GKS and followed at the Timone University Hospital, Marseille.
  • The number of tumors in Koos Stage I was 8, the average number in Stage II was 21, the average number in Stage III was 43, and the average number in Stage IV was 2.
  • Tumor control was achieved in 93% of the cases.
  • CONCLUSION: This study shows that the probability of preserving functional hearing in the long term after GKS for patients presenting with unilateral vestibular schwannomas is very high.
  • [MeSH-major] Hearing Loss, Sensorineural / etiology. Hearing Loss, Sensorineural / prevention & control. Neuroma, Acoustic / complications. Neuroma, Acoustic / surgery. Quality of Life. Radiosurgery / methods

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  • (PMID = 19057423.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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99. Gerganov VM, Romansky KV, Bussarsky VA, Noutchev LT, Iliev IN: Endoscope-assisted microsurgery of large vestibular schwannomas. Minim Invasive Neurosurg; 2005 Feb;48(1):39-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscope-assisted microsurgery of large vestibular schwannomas.
  • AIMS: The application of endoscope-assisted microsurgery in the treatment of small or medium-sized vestibular schwannomas is of proven value.
  • The goal of our study is to evaluate its usefulness in cases of large schwannomas.
  • Their average tumor diameter was 3.9 cm.
  • The endoscope was applied during all stages of tumor removal.
  • RESULTS: The facial nerve was visualized endoscopically at early stages of surgery in 9 patients and the abducent nerve in 7 patients.
  • Tumor remnants in the region of the fundus of the internal auditory canal after apparently total removal were identified in 2 cases.
  • DISCUSSION: Even in cases of large schwannomas, the location of the facial nerve can be determined endoscopically early in the procedure.
  • The application of endoscope-assisted microsurgery increases the rate of cranial nerve preservation and of total tumor removal.
  • [MeSH-major] Microsurgery / instrumentation. Neuroendoscopes. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery
  • [MeSH-minor] Adult. Aged. Facial Nerve / pathology. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prospective Studies. Treatment Outcome. Vestibulocochlear Nerve / pathology

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  • (PMID = 15747215.001).
  • [ISSN] 0946-7211
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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100. Kuo YH, Roos D, Brophy BP: Linear accelerator radiosurgery for treatment of vestibular schwannomas in neurofibromatosis 2. J Clin Neurosci; 2008 Jul;15(7):744-8
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  • [Title] Linear accelerator radiosurgery for treatment of vestibular schwannomas in neurofibromatosis 2.
  • Management of vestibular schwannomas in patients with neurofibromatosis 2 (NF2) balances growth control against preservation of hearing with the primary aim of maintaining patient quality of life.
  • Previous studies on the efficacy of stereotactic radiosurgery for vestibular schwannomas in NF2 have reported results from delivery by Gamma Knife systems.
  • Modelling studies suggest that lesional conformality is superior with Gamma Knife, but clinical studies on sporadic vestibular schwannomas show equivalent results between the two systems.
  • Our experience with LINAC radiosurgery in NF2 reported here shows good long-term growth control in four patients with vestibular schwannomas.
  • [MeSH-major] Neurofibromatosis 2 / surgery. Neuroma, Acoustic / surgery. Radiosurgery / statistics & numerical data
  • [MeSH-minor] Adult. Brain Stem / pathology. Brain Stem / physiopathology. Brain Stem / surgery. Deafness / etiology. Deafness / physiopathology. Female. Humans. Magnetic Resonance Imaging. Male. Postoperative Complications / etiology. Postoperative Complications / physiopathology. Retrospective Studies. Treatment Outcome. Vestibular Nerve / pathology. Vestibular Nerve / physiopathology. Vestibular Nerve / radiation effects

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  • (PMID = 18403208.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Scotland
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