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1. Lassaletta L, Gavilán J: [An update on the treatment of vestibular schwannoma]. Acta Otorrinolaringol Esp; 2009 Mar-Apr;60(2):131-40
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  • [Title] [An update on the treatment of vestibular schwannoma].
  • [Transliterated title] Actualización en el tratamiento del schwannoma vestibular.
  • The increase in the diagnosis of ever smaller vestibular schwannomas (VS), the fact that many tumours can be observed with serial MRI, and the development of radiosurgery as an alternative to microsurgery have led the neurotologic surgeon to a new global approach to patients with vs. On the other hand, the spread of internet-based information sources, often with biased or incomplete information, makes counselling patients with VS a challenging task.
  • Due to the completely different approach and peculiar features of bilateral VS in patients with type II neurofibromatosis, these are excluded.
  • [MeSH-major] Neuroma, Acoustic / therapy

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  • (PMID = 19401081.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 50
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2. Woodson EA, Dempewolf RD, Gubbels SP, Porter AT, Oleson JJ, Hansen MR, Gantz BJ: Long-term hearing preservation after microsurgical excision of vestibular schwannoma. Otol Neurotol; 2010 Sep;31(7):1144-52
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  • [Title] Long-term hearing preservation after microsurgical excision of vestibular schwannoma.
  • OBJECTIVE: To examine long-term hearing outcomes after microsurgical excision of vestibular schwannoma (VS).
  • Postsurgical changes do not alter the natural rate or pattern of progressive bilateral sensorineural hearing loss in individual subjects.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Hearing. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods

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  • (PMID = 20679955.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Grant] United States / NIDCD NIH HHS / DC / P50 DC000242; United States / NIDCD NIH HHS / DC / R01 DC009801; United States / NCRR NIH HHS / RR / UL1 RR025011
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS454674; NLM/ PMC3641783
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3. Evans DG, Ramsden RT, Shenton A, Gokhale C, Bowers NL, Huson SM, Pichert G, Wallace A: Mosaicism in neurofibromatosis type 2: an update of risk based on uni/bilaterality of vestibular schwannoma at presentation and sensitive mutation analysis including multiple ligation-dependent probe amplification. J Med Genet; 2007 Jul;44(7):424-8
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  • [Title] Mosaicism in neurofibromatosis type 2: an update of risk based on uni/bilaterality of vestibular schwannoma at presentation and sensitive mutation analysis including multiple ligation-dependent probe amplification.
  • RESULTS: 64 mosaic patients, with a projected mosaicism rate of 33% for sporadic classical NF2 with bilateral vestibular schwannoma at presentation and 60% for those presenting unilaterally, were identified.
  • [MeSH-major] Genetic Predisposition to Disease. Mosaicism. Neurofibromatosis 2 / complications. Neurofibromatosis 2 / genetics. Neuroma, Acoustic / etiology


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4. Dohi O, Hatori M, Ichinohasama R, Hosaka M, Hashimoto S, Kokubun S: Diffuse large B-cell lymphoma arising in a patient with neurofibromatosis type I and in a patient with neurofibromatosis type II. Tohoku J Exp Med; 2006 Feb;208(2):169-76
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  • Neurofibromatosis II typically consists of bilateral schwannomas of the acoustic nerve.

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  • (PMID = 16434841.001).
  • [ISSN] 0040-8727
  • [Journal-full-title] The Tohoku journal of experimental medicine
  • [ISO-abbreviation] Tohoku J. Exp. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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5. Fisher LM, Doherty JK, Lev MH, Slattery WH: Concordance of bilateral vestibular schwannoma growth and hearing changes in neurofibromatosis 2: neurofibromatosis 2 natural history consortium. Otol Neurotol; 2009 Sep;30(6):835-41
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  • [Title] Concordance of bilateral vestibular schwannoma growth and hearing changes in neurofibromatosis 2: neurofibromatosis 2 natural history consortium.
  • OBJECTIVE: To examine the relationship between the amount of change in size and associated hearing in bilateral vestibular schwannomas (VSs) in persons with neurofibromatosis 2 (NF2).
  • Vestibular schwannoma size changes were not associated with the corresponding hearing changes (Kendall's tau, p = not significant [n.s.]).
  • [MeSH-major] Cranial Nerve Neoplasms / pathology. Hearing Loss / etiology. Neurofibromatosis 2 / complications. Neuroma, Acoustic / pathology

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  • (PMID = 19704365.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neurofibromin 2
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6. Preuss M, Stein M, Huegens-Penzel M, Kuchelmeister K, Nestler U: Metastatic tumours mimicking vestibular schwannoma. Acta Neurochir (Wien); 2008 Sep;150(9):915-9
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  • [Title] Metastatic tumours mimicking vestibular schwannoma.
  • In this review of the literature we discuss the rare occurrence of metastatic tumours mimicking bilateral vestibular schwannoma and present an own case with pancreatic signet-ring cell carcinoma as primary tumour.
  • [MeSH-major] Carcinoma, Signet Ring Cell / diagnosis. Carcinoma, Signet Ring Cell / secondary. Ear Neoplasms / diagnosis. Ear Neoplasms / secondary. Ear, Inner. Neuroma, Acoustic / diagnosis. Pancreatic Neoplasms / pathology

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  • (PMID = 18754073.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Austria
  • [Number-of-references] 34
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7. Lustig LR, Yeagle J, Driscoll CL, Blevins N, Francis H, Niparko JK: Cochlear implantation in patients with neurofibromatosis type 2 and bilateral vestibular schwannoma. Otol Neurotol; 2006 Jun;27(4):512-8
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  • [Title] Cochlear implantation in patients with neurofibromatosis type 2 and bilateral vestibular schwannoma.
  • OBJECTIVE: To investigate the results of cochlear implantation in patients with neurofibromatosis Type 2 (NF2) and bilateral vestibular schwannoma.
  • PATIENTS: Seven patients with NF2 and bilateral vestibular schwannoma who lost hearing in at least one ear after treatment of their tumor (surgery or radiation therapy).
  • INTERVENTION: Cochlear implantation after treatment of their vestibular schwannoma.
  • CONCLUSION: In selected cases of deafness in patients with NF2 where there has been anatomic preservation of the auditory nerve after acoustic neuroma resection or radiation therapy, cochlear implantation may offer some improvement in communication skills, including the possibility of open-set speech communication in some patients.
  • [MeSH-major] Cochlear Implantation / methods. Hearing Loss, Sensorineural / etiology. Hearing Loss, Sensorineural / rehabilitation. Neurofibromatosis 2 / complications. Neuroma, Acoustic / complications


8. Siddiqui MA, Leslie T, Scott C, Mackenzie J: Eyelid schwannoma in a male adult. Clin Exp Ophthalmol; 2005 Aug;33(4):412-3
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  • [Title] Eyelid schwannoma in a male adult.
  • Schwannomas (neurilemmomas) are benign tumours of peripheral nerves arising from Schwann cells.
  • Solitary lesions can occur sporadically in the general population but multiple neurofibromas are distinctive feature of neurofibromatosis type 1 and bilateral acoustic schwannomas are a feature of neurofibromatosis type 2.
  • Schwannomas of ophthalmic interest are rare although they have been reported in relation to the orbit, and infrequently uveal tract and conjunctiva.
  • Isolated eyelid schwannomas appear infrequent; only four cases in adults and one in a child in the published literature have been found.
  • Herein, a case of eyelid schwannoma in a 53-year-old man is described.

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  • (PMID = 16033357.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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9. Shih C, Tseng FY, Yeh TH, Hsu CJ, Chen YS: Ipsilateral and contralateral acoustic brainstem response abnormalities in patients with vestibular schwannoma. Otolaryngol Head Neck Surg; 2009 Dec;141(6):695-700
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  • [Title] Ipsilateral and contralateral acoustic brainstem response abnormalities in patients with vestibular schwannoma.
  • OBJECTIVE: To analyze auditory brainstem response (ABR) data in patients with vestibular schwannomas (VS) in an effort to identify correlations between abnormal ABR parameters and tumor size.
  • SUBJECTS AND METHODS: Retrospective chart review and analysis of bilateral ABR records in patients with vs. Interaural latency differences of interpeak I-V (ILD-I-V) and ILD-V longer than 0.2 ms were used as abnormal criteria.
  • Tumor size was positively correlated with pure-tone average (P = 0.0106) and with the total number of bilateral abnormal ABR parameters (P = 0.004).
  • [MeSH-major] Evoked Potentials, Auditory, Brain Stem / physiology. Neuroma, Acoustic / physiopathology

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  • (PMID = 19932840.001).
  • [ISSN] 1097-6817
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Ramsden R, Khwaja S, Green K, O'Driscoll M, Mawman D: Vestibular schwannoma in the only hearing ear: cochlear implant or auditory brainstem implant? Otol Neurotol; 2005 Mar;26(2):261-4
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  • [Title] Vestibular schwannoma in the only hearing ear: cochlear implant or auditory brainstem implant?
  • OBJECTIVE: To explore the dilemma faced by neurotologists confronted with the patient who develops a vestibular schwannoma in the only hearing ear, the other having been deaf from birth, and to consider the choice between auditory rehabilitation using a cochlear implant (CI) on the congenitally deaf side and an auditory brainstem implant (ABI) on the tumor side.
  • STUDY DESIGN: A record review of two patients born deaf in one ear and who developed a vestibular schwannoma in the contra lateral ear, who then received a CI in the congenitally deaf ear.
  • SETTING: Tertiary referral center with special experience in vestibular schwannoma surgery, neurofibromatosis type 2 management, and cochlear implantation.
  • [MeSH-major] Auditory Brain Stem Implantation. Cochlear Implantation. Deafness / congenital. Hearing Loss, Bilateral / rehabilitation. Neuroma, Acoustic / surgery. Postoperative Complications / rehabilitation

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  • (PMID = 15793416.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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11. Plans G, Torres A, Ferran E, Aparicio A, Acebes JJ: Contralateral hearing loss after vestibular schwannoma surgery: case report. Neurosurgery; 2007 Oct;61(4):E878; discussion E878
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  • [Title] Contralateral hearing loss after vestibular schwannoma surgery: case report.
  • OBJECTIVE: To describe a case of contralateral hearing loss (CHL) in vestibular schwannoma (VS) surgery and to discuss the factors potentially related with this complication.
  • CLINICAL PRESENTATION: A 48-year-old man awakened with complete bilateral hearing loss after an uneventful retrosigmoid excision of a 20 mm left-sided vs. The patient had no complaints of vertigo or facial palsy on the contralateral side.
  • [MeSH-major] Hearing Loss, Unilateral / diagnosis. Hearing Loss, Unilateral / etiology. Neuroma, Acoustic / surgery. Postoperative Complications / diagnosis

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  • (PMID = 17986924.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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12. Bian LG, Sun QF, Tirakotai W, Zhao WG, Shen JK, Luo QZ, Bertalanffy H: Loss of heterozygosity on chromosome 22 in sporadic schwannoma and its relation to the proliferation of tumor cells. Chin Med J (Engl); 2005 Sep 20;118(18):1517-24
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  • [Title] Loss of heterozygosity on chromosome 22 in sporadic schwannoma and its relation to the proliferation of tumor cells.
  • BACKGROUND: Schwannoma is the tumor arising mainly from the cranial and spinal nerves.
  • Bilateral vestibular schwannoma is the hallmark of neurofibromatosis type 2 (NF2).
  • The NF2 gene has been cloned with comprehensive analysis of its mutations in schwannoma.
  • However, most studies focused on vestibular schwannoma.
  • There are differences in proliferation of tumor cell and ultrastructure between vestibular and spinal schwannomas.
  • It is unknown whether genetic alterations in vestibular schwannoma are different from those in non-vestibular schwannoma.
  • We analyzed the loss of heterozygosity (LOH) on chromosome 22 in patients with sporadic schwannoma including vestibular and spinal schwannomas and correlated this genetic alteration with tumor proliferation.
  • METHODS: In 54 unrelated patients without clinical NF1 or NF2, 36 patients had sporadic vestibular schwannoma, and 18 dorsal spinal root schwannoma.
  • Student's t test was used to analyze the difference of the proliferative index between schwannoma with LOH and that without LOH.
  • The difference of the frequency of LOH in vestibular and spinal schwannomas was investigated by the chi-square test.
  • RESULTS: Twenty-three schwannomas (42.6%, 23/54) showed allele loss.
  • The frequency of LOH in vestibular schwannoma was significantly higher than that in spinal schwannoma (chi2 = 5.14, P < 0.05).
  • The proliferative index of schwannoma with LOH was significantly higher than that without LOH (tki-67 = 2.97, P = 0.0045; tPCNA = 2.93, P = 0.0051).
  • CONCLUSIONS: LOH on chromosome 22 is a frequent event in the tumorigenesis of sporadic schwannoma.
  • And, there is a correlation between LOH on chromosome 22 and proliferative activity in schwannoma.
  • The frequency of LOH in vestibular schwannoma is significantly different from that in spinal schwannoma.
  • [MeSH-major] Chromosomes, Human, Pair 22. Loss of Heterozygosity. Neurilemmoma / genetics. Neuroma, Acoustic / genetics. Spinal Cord Neoplasms / genetics. Spinal Nerve Roots


13. Zanetti D, Campovecchi CB, Pasini S, Nassif N: Simultaneous translabyrinthine removal of acoustic neuroma and cochlear implantation. Auris Nasus Larynx; 2008 Dec;35(4):562-8
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  • [Title] Simultaneous translabyrinthine removal of acoustic neuroma and cochlear implantation.
  • OBJECTIVES: To report of a 65-year-old woman with bilateral Meniere's disease was referred for cochlear implantation (CI) due to severe/profound sensorineural hearing loss.
  • METHODS: During the assessment workup, a vestibular schwannoma in the right ear was found by MR imaging.
  • She underwent a translabyrinthine removal of the acoustic neuroma (AN) with sparing of the cochlear nerve and concurrent ipsilateral CI with a Nucleus Freedom device (Cochlear Ltd., Lane Cove, New South Wales, Australia).
  • CONCLUSION: Cochlear implantation at the time of acoustic neuroma removal with VIII nerve sparing can be a safe and effective hearing restoration procedure.
  • [MeSH-major] Cochlear Implantation. Hearing Loss, Sensorineural / surgery. Neuroma, Acoustic / surgery

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  • (PMID = 18243617.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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14. Stieglitz LH, Samii A, Kaminsky J, Gharabaghi A, Samii M, Lüdemann WO: Nausea and dizziness after vestibular schwannoma surgery: a multivariate analysis of preoperative symptoms. Neurosurgery; 2005 Nov;57(5):887-90; discussion 887-90
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  • [Title] Nausea and dizziness after vestibular schwannoma surgery: a multivariate analysis of preoperative symptoms.
  • OBJECTIVE: Nausea and dizziness are very discomforting for patients after vestibular schwannoma surgery and they impair recovery.
  • METHODS: To identify preoperative symptoms and conditions that increase the risk of development of nausea after vestibular schwannoma surgery, a multivariate analysis was performed.
  • One hundred fifteen patients with vestibular schwannoma had a microsurgical tumor removal in a standardized procedure in 2001 and 2002.
  • Eighteen patients were excluded from the study because of previous surgery (recurrent tumors, 7 patients) or bilateral tumor occurrence (neurofibromatosis, 11 patients).
  • Women with small tumors are most likely to develop significant complaints after vestibular schwannoma surgery.
  • CONCLUSION: It is possible to identify patients with a higher risk of postoperative nausea and dizziness after vestibular schwannoma surgery.
  • [MeSH-major] Dizziness / etiology. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / adverse effects. Postoperative Complications. Postoperative Nausea and Vomiting / etiology


15. Chen JC, Tseng SH, Chen Y, Tzeng JE, Lin SM: Cervical dumbbell meningioma and thoracic dumbbell schwannoma in a patient with neurofibromatosis. Clin Neurol Neurosurg; 2005 Apr;107(3):253-7
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  • [Title] Cervical dumbbell meningioma and thoracic dumbbell schwannoma in a patient with neurofibromatosis.
  • The occurrence of both dumbbell meningioma and dumbbell schwannoma in one patient has not been reported in the literature.
  • We present a 16-year-old female patient, who had progressive bilateral hearing impairment for 5 years and a progressively enlarged, non-tender neck mass for 1.5 years.
  • Magnetic resonance imaging (MRI) revealed bilateral cerebellopontine angle tumors, a C1-2 dumbbell tumor, and a T5-6 dumbbell tumor.
  • The pathology revealed meningioma and schwannoma, respectively.
  • Six months after the second surgery, radiosurgery was performed for the bilateral acoustic tumors, because of enlarged tumor size on follow-up MRI.
  • To the best of our knowledge, this is the first case reported in the literature of a patient, having both dumbbell meningioma and dumbbell schwannoma.

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  • (PMID = 15823685.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 19
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16. Slattery WH 3rd, Fisher LM, Hitselberger W, Friedman RA, Brackmann DE: Hearing preservation surgery for neurofibromatosis Type 2-related vestibular schwannoma in pediatric patients. J Neurosurg; 2007 Apr;106(4 Suppl):255-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hearing preservation surgery for neurofibromatosis Type 2-related vestibular schwannoma in pediatric patients.
  • OBJECT: The authors reviewed the proportion of pediatric patients with neurofibromatosis Type 2 (NF2) in whom hearing was preserved after middle fossa resection of vestibular schwannoma (VS).
  • Twelve patients had bilateral middle fossa resections; in nine (75%) of these patients hearing was maintained postoperatively in both ears.
  • [MeSH-major] Facial Nerve / physiopathology. Hearing / physiology. Neurofibromatosis 2 / surgery. Neuroma, Acoustic / surgery


17. Ito E, Saito K, Yatsuya H, Nagatani T, Otsuka G: Factors predicting growth of vestibular schwannoma in neurofibromatosis type 2. Neurosurg Rev; 2009 Oct;32(4):425-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Factors predicting growth of vestibular schwannoma in neurofibromatosis type 2.
  • We retrospectively reviewed characteristics of patients with neurofibromatosis type 2 to identify factors predicting further growth of bilateral vestibular schwannomas.
  • Subjects comprised 27 neurofibromatosis type 2 patients with 54 vestibular schwannomas, followed for 24-204 months (mean, 86 months).
  • This study investigated factors predictive of vestibular schwannoma growth in neurofibromatosis type 2.
  • Features distinguishing actively growing from quiescent VS were determined for untreated course (28 vestibular schwannomas) and posttreatment course (including either resection or radiosurgery; 33 vestibular schwannomas).
  • During the untreated course, 19 vestibular schwannomas showed growth and 9 vestibular schwannomas were stable.
  • [MeSH-major] Cranial Nerve Neoplasms / pathology. Neurofibromatosis 2 / pathology. Neuroma, Acoustic / pathology. Trigeminal Nerve / pathology


18. Arístegui M, Denia A: Simultaneous cochlear implantation and translabyrinthine removal of vestibular schwannoma in an only hearing ear: report of two cases (neurofibromatosis type 2 and unilateral vestibular schwannoma). Otol Neurotol; 2005 Mar;26(2):205-10
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  • [Title] Simultaneous cochlear implantation and translabyrinthine removal of vestibular schwannoma in an only hearing ear: report of two cases (neurofibromatosis type 2 and unilateral vestibular schwannoma).
  • STUDY DESIGN: This is a retrospective case review of two cases of vestibular schwannoma (VS) in the only hearing ear in which a cochlear implant (CI) was placed simultaneous to removal of VS through a modified enlarged translabyrinthine approach.
  • [MeSH-major] Cochlear Implantation / methods. Hearing Loss, Bilateral / surgery. Neurofibromatosis 2 / surgery. Neuroma, Acoustic / surgery

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  • (PMID = 15793406.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Evans DG, Ramsden RT, Shenton A, Gokhale C, Bowers N, Huson SM, Wallace AJ: What are the implications in individuals with unilateral vestibular schwannoma and other neurogenic tumors? J Neurosurg; 2008 Jan;108(1):92-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] What are the implications in individuals with unilateral vestibular schwannoma and other neurogenic tumors?
  • OBJECTIVES: Individuals who develop a unilateral vestibular schwannoma (VS) and other neurogenic tumors are at high risk of having the inherited condition neurofibromatosis Type 2 (NF2).
  • The risk of bilateral disease and transmission risk to offspring are important in surgical planning and counseling.
  • METHODS: A large NF2 dataset was interrogated for individuals who had initially presented with a unilateral VS and other tumors before developing bilateral disease, to assess the contralateral and offspring risks.
  • [MeSH-major] Genes, Neurofibromatosis 2 / physiology. Mosaicism. Neuroma, Acoustic / genetics. Neuroma, Acoustic / pathology

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  • (PMID = 18173316.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Durko M, Jankowski A, Durko T, Gajewicz W, Pajor A: [Coexistence of acoustic neuroma and pineal region tumor in patient with sudden deafness]. Otolaryngol Pol; 2008;62(2):204-8
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  • [Title] [Coexistence of acoustic neuroma and pineal region tumor in patient with sudden deafness].
  • INTRODUCTION: Acoustic neuroma usually presents as an unilateral tumor, seldom - bilateral and rarely in coexistence with other central nervous system neoplasms.
  • MRI study revealed in the left internal acoustic meatus mass (7 x 7 x 14 mm) suggesting acoustic neuroma and an oval mass (7 x 9 x 14 mm) in the pineal gland presenting radiological features of pinealoma.
  • Acoustic neuroma has been removed by suboccipital approach and pinealoma has been left for further observation as it was found incidentally.
  • Histopathological examination confirmed diagnosis of left VIII nerve schwannoma.
  • The postoperative course shows no evidence of acoustic neuroma recurrence.
  • [MeSH-major] Deafness / etiology. Neoplasms, Second Primary / diagnosis. Neuroma, Acoustic / diagnosis. Pinealoma / diagnosis

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  • (PMID = 18637448.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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21. Kiratli H, Yildiz S, Soylemezoğlu F: Neurofibromatosis type 2: optic nerve sheath meningioma in one orbit, intramuscular schwannoma in the other. Orbit; 2008;27(6):451-4
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  • [Title] Neurofibromatosis type 2: optic nerve sheath meningioma in one orbit, intramuscular schwannoma in the other.
  • A highly unusual patient with neurofibromatosis type 2 (NF2) presenting with simultaneous bilateral orbital tumors is described.
  • A 12-year-old girl with a family history of NF2 was examined because of bilateral proptosis.
  • Magnetic resonance imaging studies showed bilateral cerebellopontine angle tumors, a tumor surrounding the right intraorbital optic nerve, and a large left lateral orbital mass mixed with the lateral rectus muscle.
  • The histopathological diagnoses following incisional biopsies were right optic nerve sheath meningioma and left intramuscular schwannoma.
  • The left-sided orbital schwannoma and the right-sided vestibular schwannoma were treated with fractionated stereotactic radiotherapy.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Child. Female. Functional Laterality. Hamartoma / pathology. Humans. Magnetic Resonance Imaging. Neoplasm Proteins / analysis. Neuroma, Acoustic / chemistry. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Oculomotor Muscles / pathology. Radiosurgery. Radiotherapy, Conformal. Retinal Diseases / pathology

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  • (PMID = 19085302.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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22. Walcott BP, Sivarajan G, Bashinskaya B, Anderson DE, Leonetti JP, Origitano TC: Sporadic unilateral vestibular schwannoma in the pediatric population. Clinical article. J Neurosurg Pediatr; 2009 Aug;4(2):125-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sporadic unilateral vestibular schwannoma in the pediatric population. Clinical article.
  • OBJECT: Vestibular schwannomas (VSs) are rare in the pediatric population.
  • Most often, these lesions manifest as a bilateral disease process in the setting of neurofibromatosis Type 2.
  • [MeSH-major] Facial Nerve / physiopathology. Neuroma, Acoustic / surgery

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  • (PMID = 19645545.001).
  • [ISSN] 1933-0707
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Sone M, Katayama N, Otake N, Sato E, Fujimoto Y, Ito M, Nakashima T: Characterizing the auditory changes in tumor metastasis to the bilateral internal auditory canals. J Clin Neurosci; 2007 May;14(5):470-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Characterizing the auditory changes in tumor metastasis to the bilateral internal auditory canals.
  • We report the changes in auditory function in a patient with tumor metastasis to the bilateral internal auditory canals (IAC).
  • Metastatic tumors in the bilateral IAC have been reported to mimic neurofibromatosis type 2, and radiological differentiation from acoustic schwannoma is difficult.
  • [MeSH-minor] Acoustic Stimulation / methods. Adenocarcinoma / pathology. Gastrointestinal Neoplasms / pathology. Humans. Male. Middle Aged

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  • (PMID = 17386369.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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24. Harris GJ, Plotkin SR, Maccollin M, Bhat S, Urban T, Lev MH, Slattery WH: Three-dimensional volumetrics for tracking vestibular schwannoma growth in neurofibromatosis type II. Neurosurgery; 2008 Jun;62(6):1314-9; discussion 1319-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Three-dimensional volumetrics for tracking vestibular schwannoma growth in neurofibromatosis type II.
  • OBJECTIVE: Vestibular schwannomas (VS) are common, benign, VIIIth cranial nerve tumors.
  • Treatment in patients with the genetic disorder neurofibromatosis type II (NF2) is complicated by their development of bilateral VS and risk of complete deafness.
  • [MeSH-major] Imaging, Three-Dimensional. Magnetic Resonance Imaging. Neurofibromatosis 2 / pathology. Neuroma, Acoustic / pathology


25. Samii A, Lenarz M, Majdani O, Lim HH, Samii M, Lenarz T: Auditory midbrain implant: a combined approach for vestibular schwannoma surgery and device implantation. Otol Neurotol; 2007 Jan;28(1):31-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Auditory midbrain implant: a combined approach for vestibular schwannoma surgery and device implantation.
  • HYPOTHESIS: The lateral suboccipital approach is a well-established route for safe removal of vestibular schwannomas in neurofibromatosis Type 2 (NF2) patients.
  • The initial candidates are NF2 patients who, because of the growth and/or surgical removal of bilateral acoustic neuromas, develop neural deafness and are unable to benefit from cochlear implants.
  • The ideal surgical approach in NF2 patients must first enable safe removal of vestibular schwannomas and then provide sufficient exposure of the midbrain for AMI implantation.
  • CONCLUSION: This modified lateral suboccipital approach ensures safe removal of large vestibular schwannomas and provides sufficient exposure of the inferior colliculus for ideal AMI implantation.
  • [MeSH-major] Auditory Brain Stem Implants. Deafness / etiology. Deafness / surgery. Neuroma, Acoustic / complications. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods

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  • (PMID = 17195743.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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26. Sen A, Khan MI, Ramsden RT, Gillespie JE: Stenosis of the internal auditory meatus masquerading as bilateral vestibular schwannomas: a cautionary tale. J Laryngol Otol; 2005 Dec;119(12):995-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Stenosis of the internal auditory meatus masquerading as bilateral vestibular schwannomas: a cautionary tale.
  • They are known to symptomatically mimic vestibular schwannomas leading to potential diagnostic error.
  • We present a case (along with literature review) where a stenotic IAM was clinically and radiologically misdiagnosed as a vestibular schwannoma.
  • [MeSH-major] Cranial Nerve Neoplasms / diagnosis. Ear, Inner. Labyrinth Diseases / diagnosis. Neuroma, Acoustic / diagnosis. Vestibulocochlear Nerve Diseases / diagnosis

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  • (PMID = 16354367.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 8
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27. Aghi M, Kluwe L, Webster MT, Jacoby LB, Barker FG 2nd, Ojemann RG, Mautner VF, MacCollin M: Unilateral vestibular schwannoma with other neurofibromatosis type 2-related tumors: clinical and molecular study of a unique phenotype. J Neurosurg; 2006 Feb;104(2):201-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unilateral vestibular schwannoma with other neurofibromatosis type 2-related tumors: clinical and molecular study of a unique phenotype.
  • OBJECT: Although the manifestations of neurofibromatosis Type 2 (NF2) vary, the hallmark is bilateral vestibular schwannomas (VSs).
  • [MeSH-major] Neurofibromatosis 2 / complications. Neuroma, Acoustic / genetics. Neuroma, Acoustic / pathology


28. Fayad JN, Otto SR, Brackmann DE: Auditory brainstem implants: surgical aspects. Adv Otorhinolaryngol; 2006;64:144-53

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Patients with neurofibromatosis type 2 often develop bilateral life-threatening vestibular schwannoma necessitating tumor removal, which results in deafness.
  • We developed the auditory brainstem implant (ABI) in order to be able to electrically stimulate the cochlear nucleus complex in patients with bilateral cochlear nerve injury from bilateral schwannoma.
  • [MeSH-minor] Ear, Inner / surgery. Humans. Neurofibromatosis 2 / complications. Neurofibromatosis 2 / physiopathology. Neuroma, Acoustic / complications. Neuroma, Acoustic / etiology. Patient Selection. Prostheses and Implants. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16891840.001).
  • [ISSN] 0065-3071
  • [Journal-full-title] Advances in oto-rhino-laryngology
  • [ISO-abbreviation] Adv. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 16
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29. White JB, Scheithauer BW, Amrami KK, Babovic-Vuksanovic D, Spinner RJ: Contiguous conventional and plexiform schwannomas. Report of two cases. J Neurosurg; 2006 Feb;104(2):319-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Contiguous conventional and plexiform schwannomas. Report of two cases.
  • The authors present clinical, imaging, and histological features of two adult patients found to harbor a conventional schwannoma contiguous with a deep plexiform schwannoma.
  • One patient had neurofibromatosis (NF) Type 2 (NF2), and both intracranial (bilateral oculomotor, trigeminal, acoustic, and hypoglossal schwannomas as well as meningiomas) and intraspinal (schwannomas and meningiomas) lesions.
  • The proximal forearm lesions consisted of a conventional schwannoma and an underlying plexiform component.
  • Plexiform schwannomas are rare lesions that occur sporadically or, on occasion, in association with NF2 or meningiomas with or without multiple schwannomas.
  • The authors believe that a more careful examination of patients with NF2 may show that these people have a higher incidence of plexiform schwannoma than previously thought.
  • Pathological confirmation is crucial in distinguishing plexiform schwannomas from plexiform neurofibromas, because the latter are directly associated with NF1 and have a significant tendency to undergo malignant transformation.
  • To the best of the authors' knowledge, this is the first report of a conventional schwannoma contiguous with a deep plexiform schwannoma.

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  • (PMID = 16509508.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Feiden S, Sartorius E, Feiden W: [The role of diagnostic neuropathology in familial tumour syndromes]. Pathologe; 2010 Oct;31(6):464-70
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  • Furthermore, tumour location and patient age may point to a familial tumour syndrome as in the case of neurofibromatosis type 2 (NF2) with typical bilateral vestibular schwannoma in young age.
  • [MeSH-minor] Central Nervous System Neoplasms / genetics. Central Nervous System Neoplasms / pathology. Chromosome Mapping. Chromosomes, Human, Pair 16. Chromosomes, Human, Pair 17. Chromosomes, Human, Pair 22. Chromosomes, Human, Pair 9. Genes, Neurofibromatosis 1. Genes, Neurofibromatosis 2. Humans. Li-Fraumeni Syndrome / genetics. Li-Fraumeni Syndrome / pathology. Neurofibromatosis 1 / genetics. Neurofibromatosis 1 / pathology. Neurofibromatosis 2 / genetics. Neurofibromatosis 2 / pathology. Neuroma, Acoustic / genetics. Neuroma, Acoustic / pathology. Peripheral Nervous System Neoplasms / genetics. Peripheral Nervous System Neoplasms / pathology. Rhabdoid Tumor / genetics. Rhabdoid Tumor / pathology. Teratoma / genetics. Teratoma / pathology. Tuberous Sclerosis / genetics. Tuberous Sclerosis / pathology

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  • (PMID = 20848106.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
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31. Roche PH, Khalil M, Soumare O, Régis J: Hydrocephalus and vestibular schwannomas: considerations about the impact of gamma knife radiosurgery. Prog Neurol Surg; 2008;21:200-6
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  • [Title] Hydrocephalus and vestibular schwannomas: considerations about the impact of gamma knife radiosurgery.
  • Hydrocephalus may occur at various stages of the natural course of vestibular schwannoma and can also be diagnosed after the therapeutic procedure.
  • Among the first 1,000 vestibular schwannoma patients treated by GKR in our institution, 30 patients (3%) belonged to group A and 1% to group B.
  • In both groups, hydrocephalus was more often associated with the following data: Elderly, large tumor, previous MS, NF2 disease and bilateral tumors.
  • [MeSH-major] Hydrocephalus / epidemiology. Neuroma, Acoustic / surgery. Radiosurgery

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  • (PMID = 18810220.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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32. Neff BA, Wiet RM, Lasak JM, Cohen NL, Pillsbury HC, Ramsden RT, Welling DB: Cochlear implantation in the neurofibromatosis type 2 patient: long-term follow-up. Laryngoscope; 2007 Jun;117(6):1069-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: Patients with NF2-associated bilateral vestibular schwannomas frequently become profoundly deaf.
  • Frequently, tumor size or poor preoperative hearing status can require a surgical approach that leaves the patient with a profound, bilateral sensorineural hearing loss.
  • If the cochlear nerve is preserved anatomically after vestibular schwannoma surgery, and if promontory stimulation confirms the functionality of the cochlear nerve, then cochlear implantation is an excellent option to restore hearing.
  • CONCLUSION: Early surgical intervention for vestibular schwannomas in NF2 patients when the cochlear nerve can be spared is an important consideration to allow for possible cochlear implantation.
  • [MeSH-major] Cochlear Implantation. Hearing Loss, Sensorineural / etiology. Hearing Loss, Sensorineural / surgery. Neurofibromatosis 2 / complications. Neuroma, Acoustic / etiology


33. Bouccara D, Kalamarides M, Bozorg Grayeli A, Ambert-Dahan E, Rey A, Sterkers O: [Auditory brainstem implant: indications and results]. Ann Otolaryngol Chir Cervicofac; 2007 Jul;124(3):148-54

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Implant auditif du tronc cérébral: indications et résultats.
  • Emergent indications are bilateral total ossified cochlea, vestibular schwannoma with controlateral lesions, cochlear nerve aplasia or inner ear's malformations.
  • RESULTS: In NF2 patients, best results are obtained in cases of smaller vestibular schwannoma and none, or short term, auditory deprivation.
  • [MeSH-minor] Brain / pathology. Calcinosis / etiology. Calcinosis / pathology. Cochlear Diseases / etiology. Cochlear Diseases / pathology. Cochlear Nerve / pathology. Cochlear Nerve / surgery. Electrodes, Implanted. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Neurofibromatosis 2 / complications. Neuroma, Acoustic / complications. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery

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  • (PMID = 17320034.001).
  • [ISSN] 0003-438X
  • [Journal-full-title] Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris
  • [ISO-abbreviation] Ann Otolaryngol Chir Cervicofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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34. Stieglitz LH, Wrede KH, Gharabaghi A, Gerganov VM, Samii A, Samii M, Luedemann WO: Factors affecting postoperative cerebrospinal fluid leaks after retrosigmoidal craniotomy for vestibular schwannomas. J Neurosurg; 2009 Oct;111(4):874-83
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  • [Title] Factors affecting postoperative cerebrospinal fluid leaks after retrosigmoidal craniotomy for vestibular schwannomas.
  • OBJECT: The aim of this study was to identify patients likely to develop CSF leaks after vestibular schwannoma surgery using a retrospective analysis for the identification of risk factors.
  • Twenty-six patients had bilateral tumors due to neurofibromatosis Type 2, and 4 patients had previously undergone radiosurgical treatment.
  • [MeSH-major] Craniotomy / adverse effects. Craniotomy / methods. Neuroma, Acoustic / surgery. Subdural Effusion / etiology

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  • (PMID = 19326990.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 42
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35. Bobest M, Tóth C, Gyurcsó M, Molnár MJ, Garzuly F: [Nonsense mutation 193C&gt;T of neurofibromatosis type 2--a neurosurgical challenge]. Ideggyogy Sz; 2007 Jan 20;60(1-2):41-5
Genetic Alliance. consumer health - Neurofibromatosis type 2.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 15 years old male was operated because of incidentally found intercostal schwannoma.
  • MRI revealed bilateral vestibularis tumors and multiple cervical intradural extramedullary myelin compressing lesions.
  • After partial resection of the huge left sided cerebello-pontine tumor, histologically schwannoma, and the extirpation of the multiple cervical meningiomas the patient died three months later due to septic complications.
  • Her 14 years old twins are living, a boy also with bilateral acoustic tumours and a girl who is intact.

  • Genetic Alliance. consumer health - Neurofibromatosis.
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  • (PMID = 17432093.001).
  • [ISSN] 0019-1442
  • [Journal-full-title] Ideggyógyászati szemle
  • [ISO-abbreviation] Ideggyogy Sz
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Codon, Nonsense; 8J337D1HZY / Cytosine; QR26YLT7LT / Thymine
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36. Cotticelli L, Romano M, Russo S, Borrelli M: Neurofibromatosis type 2: a case of ptosis. Graefes Arch Clin Exp Ophthalmol; 2007 Sep;245(9):1393-6
Genetic Alliance. consumer health - Ptosis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The hallmark is bilateral vestibular schwannomas, which may not appear until after the second decade.
  • Other cranial nerve schwannomas occur as well.
  • In addition, there may be schwannomas of spinal nerve roots or peripheral nerves, as well as meningiomas, gliomas, and ependymomas.
  • The patient showed positive familiar history for NF (the father was affected), bilateral involvement of the acoustic nerves (schwannoma), multiple neurofibromas, and bilateral posterior subcapsular lens opacity.
  • Magnetic resonance imaging (MRI) showed bilateral acoustic neuromas in the left temporal region close to the cavernous sinus; since neurological examination and ocular motility problems had remained stationary over time, surgical correction of ptosis and strabismus was suggested.

  • Genetic Alliance. consumer health - Neurofibromatosis.
  • Genetic Alliance. consumer health - Neurofibromatosis type 2.
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  • (PMID = 17347811.001).
  • [ISSN] 0721-832X
  • [Journal-full-title] Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie
  • [ISO-abbreviation] Graefes Arch. Clin. Exp. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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