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1. Bian LG, Sun QF, Tirakotai W, Zhao WG, Shen JK, Luo QZ, Bertalanffy H: Loss of heterozygosity on chromosome 22 in sporadic schwannoma and its relation to the proliferation of tumor cells. Chin Med J (Engl); 2005 Sep 20;118(18):1517-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Loss of heterozygosity on chromosome 22 in sporadic schwannoma and its relation to the proliferation of tumor cells.
  • BACKGROUND: Schwannoma is the tumor arising mainly from the cranial and spinal nerves.
  • Bilateral vestibular schwannoma is the hallmark of neurofibromatosis type 2 (NF2).
  • The NF2 gene has been cloned with comprehensive analysis of its mutations in schwannoma.
  • However, most studies focused on vestibular schwannoma.
  • There are differences in proliferation of tumor cell and ultrastructure between vestibular and spinal schwannomas.
  • It is unknown whether genetic alterations in vestibular schwannoma are different from those in non-vestibular schwannoma.
  • We analyzed the loss of heterozygosity (LOH) on chromosome 22 in patients with sporadic schwannoma including vestibular and spinal schwannomas and correlated this genetic alteration with tumor proliferation.
  • METHODS: In 54 unrelated patients without clinical NF1 or NF2, 36 patients had sporadic vestibular schwannoma, and 18 dorsal spinal root schwannoma.
  • Student's t test was used to analyze the difference of the proliferative index between schwannoma with LOH and that without LOH.
  • The difference of the frequency of LOH in vestibular and spinal schwannomas was investigated by the chi-square test.
  • RESULTS: Twenty-three schwannomas (42.6%, 23/54) showed allele loss.
  • The frequency of LOH in vestibular schwannoma was significantly higher than that in spinal schwannoma (chi2 = 5.14, P < 0.05).
  • The proliferative index of schwannoma with LOH was significantly higher than that without LOH (tki-67 = 2.97, P = 0.0045; tPCNA = 2.93, P = 0.0051).
  • CONCLUSIONS: LOH on chromosome 22 is a frequent event in the tumorigenesis of sporadic schwannoma.
  • And, there is a correlation between LOH on chromosome 22 and proliferative activity in schwannoma.
  • The frequency of LOH in vestibular schwannoma is significantly different from that in spinal schwannoma.
  • [MeSH-major] Chromosomes, Human, Pair 22. Loss of Heterozygosity. Neurilemmoma / genetics. Neuroma, Acoustic / genetics. Spinal Cord Neoplasms / genetics. Spinal Nerve Roots


2. Lustig LR, Yeagle J, Driscoll CL, Blevins N, Francis H, Niparko JK: Cochlear implantation in patients with neurofibromatosis type 2 and bilateral vestibular schwannoma. Otol Neurotol; 2006 Jun;27(4):512-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cochlear implantation in patients with neurofibromatosis type 2 and bilateral vestibular schwannoma.
  • OBJECTIVE: To investigate the results of cochlear implantation in patients with neurofibromatosis Type 2 (NF2) and bilateral vestibular schwannoma.
  • PATIENTS: Seven patients with NF2 and bilateral vestibular schwannoma who lost hearing in at least one ear after treatment of their tumor (surgery or radiation therapy).
  • INTERVENTION: Cochlear implantation after treatment of their vestibular schwannoma.
  • CONCLUSION: In selected cases of deafness in patients with NF2 where there has been anatomic preservation of the auditory nerve after acoustic neuroma resection or radiation therapy, cochlear implantation may offer some improvement in communication skills, including the possibility of open-set speech communication in some patients.
  • [MeSH-major] Cochlear Implantation / methods. Hearing Loss, Sensorineural / etiology. Hearing Loss, Sensorineural / rehabilitation. Neurofibromatosis 2 / complications. Neuroma, Acoustic / complications


3. Siddiqui MA, Leslie T, Scott C, Mackenzie J: Eyelid schwannoma in a male adult. Clin Exp Ophthalmol; 2005 Aug;33(4):412-3
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  • [Title] Eyelid schwannoma in a male adult.
  • Schwannomas (neurilemmomas) are benign tumours of peripheral nerves arising from Schwann cells.
  • Solitary lesions can occur sporadically in the general population but multiple neurofibromas are distinctive feature of neurofibromatosis type 1 and bilateral acoustic schwannomas are a feature of neurofibromatosis type 2.
  • Schwannomas of ophthalmic interest are rare although they have been reported in relation to the orbit, and infrequently uveal tract and conjunctiva.
  • Isolated eyelid schwannomas appear infrequent; only four cases in adults and one in a child in the published literature have been found.
  • Herein, a case of eyelid schwannoma in a 53-year-old man is described.

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  • (PMID = 16033357.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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4. Sone M, Katayama N, Otake N, Sato E, Fujimoto Y, Ito M, Nakashima T: Characterizing the auditory changes in tumor metastasis to the bilateral internal auditory canals. J Clin Neurosci; 2007 May;14(5):470-3
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  • [Title] Characterizing the auditory changes in tumor metastasis to the bilateral internal auditory canals.
  • We report the changes in auditory function in a patient with tumor metastasis to the bilateral internal auditory canals (IAC).
  • Metastatic tumors in the bilateral IAC have been reported to mimic neurofibromatosis type 2, and radiological differentiation from acoustic schwannoma is difficult.
  • [MeSH-minor] Acoustic Stimulation / methods. Adenocarcinoma / pathology. Gastrointestinal Neoplasms / pathology. Humans. Male. Middle Aged

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  • (PMID = 17386369.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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5. Durko M, Jankowski A, Durko T, Gajewicz W, Pajor A: [Coexistence of acoustic neuroma and pineal region tumor in patient with sudden deafness]. Otolaryngol Pol; 2008;62(2):204-8
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  • [Title] [Coexistence of acoustic neuroma and pineal region tumor in patient with sudden deafness].
  • INTRODUCTION: Acoustic neuroma usually presents as an unilateral tumor, seldom - bilateral and rarely in coexistence with other central nervous system neoplasms.
  • MRI study revealed in the left internal acoustic meatus mass (7 x 7 x 14 mm) suggesting acoustic neuroma and an oval mass (7 x 9 x 14 mm) in the pineal gland presenting radiological features of pinealoma.
  • Acoustic neuroma has been removed by suboccipital approach and pinealoma has been left for further observation as it was found incidentally.
  • Histopathological examination confirmed diagnosis of left VIII nerve schwannoma.
  • The postoperative course shows no evidence of acoustic neuroma recurrence.
  • [MeSH-major] Deafness / etiology. Neoplasms, Second Primary / diagnosis. Neuroma, Acoustic / diagnosis. Pinealoma / diagnosis


6. Fayad JN, Otto SR, Brackmann DE: Auditory brainstem implants: surgical aspects. Adv Otorhinolaryngol; 2006;64:144-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Patients with neurofibromatosis type 2 often develop bilateral life-threatening vestibular schwannoma necessitating tumor removal, which results in deafness.
  • We developed the auditory brainstem implant (ABI) in order to be able to electrically stimulate the cochlear nucleus complex in patients with bilateral cochlear nerve injury from bilateral schwannoma.
  • [MeSH-minor] Ear, Inner / surgery. Humans. Neurofibromatosis 2 / complications. Neurofibromatosis 2 / physiopathology. Neuroma, Acoustic / complications. Neuroma, Acoustic / etiology. Patient Selection. Prostheses and Implants. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16891840.001).
  • [ISSN] 0065-3071
  • [Journal-full-title] Advances in oto-rhino-laryngology
  • [ISO-abbreviation] Adv. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 16
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23. Roche PH, Khalil M, Soumare O, Régis J: Hydrocephalus and vestibular schwannomas: considerations about the impact of gamma knife radiosurgery. Prog Neurol Surg; 2008;21:200-6
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  • [Title] Hydrocephalus and vestibular schwannomas: considerations about the impact of gamma knife radiosurgery.
  • Hydrocephalus may occur at various stages of the natural course of vestibular schwannoma and can also be diagnosed after the therapeutic procedure.
  • Among the first 1,000 vestibular schwannoma patients treated by GKR in our institution, 30 patients (3%) belonged to group A and 1% to group B.
  • In both groups, hydrocephalus was more often associated with the following data: Elderly, large tumor, previous MS, NF2 disease and bilateral tumors.
  • [MeSH-major] Hydrocephalus / epidemiology. Neuroma, Acoustic / surgery. Radiosurgery

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  • (PMID = 18810220.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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24. Chen JC, Tseng SH, Chen Y, Tzeng JE, Lin SM: Cervical dumbbell meningioma and thoracic dumbbell schwannoma in a patient with neurofibromatosis. Clin Neurol Neurosurg; 2005 Apr;107(3):253-7
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  • [Title] Cervical dumbbell meningioma and thoracic dumbbell schwannoma in a patient with neurofibromatosis.
  • The occurrence of both dumbbell meningioma and dumbbell schwannoma in one patient has not been reported in the literature.
  • We present a 16-year-old female patient, who had progressive bilateral hearing impairment for 5 years and a progressively enlarged, non-tender neck mass for 1.5 years.
  • Magnetic resonance imaging (MRI) revealed bilateral cerebellopontine angle tumors, a C1-2 dumbbell tumor, and a T5-6 dumbbell tumor.
  • The pathology revealed meningioma and schwannoma, respectively.
  • Six months after the second surgery, radiosurgery was performed for the bilateral acoustic tumors, because of enlarged tumor size on follow-up MRI.
  • To the best of our knowledge, this is the first case reported in the literature of a patient, having both dumbbell meningioma and dumbbell schwannoma.

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  • (PMID = 15823685.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 19
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25. Aghi M, Kluwe L, Webster MT, Jacoby LB, Barker FG 2nd, Ojemann RG, Mautner VF, MacCollin M: Unilateral vestibular schwannoma with other neurofibromatosis type 2-related tumors: clinical and molecular study of a unique phenotype. J Neurosurg; 2006 Feb;104(2):201-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unilateral vestibular schwannoma with other neurofibromatosis type 2-related tumors: clinical and molecular study of a unique phenotype.
  • OBJECT: Although the manifestations of neurofibromatosis Type 2 (NF2) vary, the hallmark is bilateral vestibular schwannomas (VSs).
  • [MeSH-major] Neurofibromatosis 2 / complications. Neuroma, Acoustic / genetics. Neuroma, Acoustic / pathology


26. Bobest M, Tóth C, Gyurcsó M, Molnár MJ, Garzuly F: [Nonsense mutation 193C&gt;T of neurofibromatosis type 2--a neurosurgical challenge]. Ideggyogy Sz; 2007 Jan 20;60(1-2):41-5
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  • A 15 years old male was operated because of incidentally found intercostal schwannoma.
  • MRI revealed bilateral vestibularis tumors and multiple cervical intradural extramedullary myelin compressing lesions.
  • After partial resection of the huge left sided cerebello-pontine tumor, histologically schwannoma, and the extirpation of the multiple cervical meningiomas the patient died three months later due to septic complications.
  • Her 14 years old twins are living, a boy also with bilateral acoustic tumours and a girl who is intact.

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  • (PMID = 17432093.001).
  • [ISSN] 0019-1442
  • [Journal-full-title] Ideggyógyászati szemle
  • [ISO-abbreviation] Ideggyogy Sz
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Codon, Nonsense; 8J337D1HZY / Cytosine; QR26YLT7LT / Thymine
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27. Ito E, Saito K, Yatsuya H, Nagatani T, Otsuka G: Factors predicting growth of vestibular schwannoma in neurofibromatosis type 2. Neurosurg Rev; 2009 Oct;32(4):425-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Factors predicting growth of vestibular schwannoma in neurofibromatosis type 2.
  • We retrospectively reviewed characteristics of patients with neurofibromatosis type 2 to identify factors predicting further growth of bilateral vestibular schwannomas.
  • Subjects comprised 27 neurofibromatosis type 2 patients with 54 vestibular schwannomas, followed for 24-204 months (mean, 86 months).
  • This study investigated factors predictive of vestibular schwannoma growth in neurofibromatosis type 2.
  • Features distinguishing actively growing from quiescent VS were determined for untreated course (28 vestibular schwannomas) and posttreatment course (including either resection or radiosurgery; 33 vestibular schwannomas).
  • During the untreated course, 19 vestibular schwannomas showed growth and 9 vestibular schwannomas were stable.
  • [MeSH-major] Cranial Nerve Neoplasms / pathology. Neurofibromatosis 2 / pathology. Neuroma, Acoustic / pathology. Trigeminal Nerve / pathology


28. Zanetti D, Campovecchi CB, Pasini S, Nassif N: Simultaneous translabyrinthine removal of acoustic neuroma and cochlear implantation. Auris Nasus Larynx; 2008 Dec;35(4):562-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Simultaneous translabyrinthine removal of acoustic neuroma and cochlear implantation.
  • OBJECTIVES: To report of a 65-year-old woman with bilateral Meniere's disease was referred for cochlear implantation (CI) due to severe/profound sensorineural hearing loss.
  • METHODS: During the assessment workup, a vestibular schwannoma in the right ear was found by MR imaging.
  • She underwent a translabyrinthine removal of the acoustic neuroma (AN) with sparing of the cochlear nerve and concurrent ipsilateral CI with a Nucleus Freedom device (Cochlear Ltd., Lane Cove, New South Wales, Australia).
  • CONCLUSION: Cochlear implantation at the time of acoustic neuroma removal with VIII nerve sparing can be a safe and effective hearing restoration procedure.
  • [MeSH-major] Cochlear Implantation. Hearing Loss, Sensorineural / surgery. Neuroma, Acoustic / surgery


29. Kiratli H, Yildiz S, Soylemezoğlu F: Neurofibromatosis type 2: optic nerve sheath meningioma in one orbit, intramuscular schwannoma in the other. Orbit; 2008;27(6):451-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neurofibromatosis type 2: optic nerve sheath meningioma in one orbit, intramuscular schwannoma in the other.
  • A highly unusual patient with neurofibromatosis type 2 (NF2) presenting with simultaneous bilateral orbital tumors is described.
  • A 12-year-old girl with a family history of NF2 was examined because of bilateral proptosis.
  • Magnetic resonance imaging studies showed bilateral cerebellopontine angle tumors, a tumor surrounding the right intraorbital optic nerve, and a large left lateral orbital mass mixed with the lateral rectus muscle.
  • The histopathological diagnoses following incisional biopsies were right optic nerve sheath meningioma and left intramuscular schwannoma.
  • The left-sided orbital schwannoma and the right-sided vestibular schwannoma were treated with fractionated stereotactic radiotherapy.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Child. Female. Functional Laterality. Hamartoma / pathology. Humans. Magnetic Resonance Imaging. Neoplasm Proteins / analysis. Neuroma, Acoustic / chemistry. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Oculomotor Muscles / pathology. Radiosurgery. Radiotherapy, Conformal. Retinal Diseases / pathology


30. Sen A, Khan MI, Ramsden RT, Gillespie JE: Stenosis of the internal auditory meatus masquerading as bilateral vestibular schwannomas: a cautionary tale. J Laryngol Otol; 2005 Dec;119(12):995-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Stenosis of the internal auditory meatus masquerading as bilateral vestibular schwannomas: a cautionary tale.
  • They are known to symptomatically mimic vestibular schwannomas leading to potential diagnostic error.
  • We present a case (along with literature review) where a stenotic IAM was clinically and radiologically misdiagnosed as a vestibular schwannoma.
  • [MeSH-major] Cranial Nerve Neoplasms / diagnosis. Ear, Inner. Labyrinth Diseases / diagnosis. Neuroma, Acoustic / diagnosis. Vestibulocochlear Nerve Diseases / diagnosis

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  • (PMID = 16354367.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 8
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31. Fisher LM, Doherty JK, Lev MH, Slattery WH: Concordance of bilateral vestibular schwannoma growth and hearing changes in neurofibromatosis 2: neurofibromatosis 2 natural history consortium. Otol Neurotol; 2009 Sep;30(6):835-41
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  • [Title] Concordance of bilateral vestibular schwannoma growth and hearing changes in neurofibromatosis 2: neurofibromatosis 2 natural history consortium.
  • OBJECTIVE: To examine the relationship between the amount of change in size and associated hearing in bilateral vestibular schwannomas (VSs) in persons with neurofibromatosis 2 (NF2).
  • Vestibular schwannoma size changes were not associated with the corresponding hearing changes (Kendall's tau, p = not significant [n.s.]).
  • [MeSH-major] Cranial Nerve Neoplasms / pathology. Hearing Loss / etiology. Neurofibromatosis 2 / complications. Neuroma, Acoustic / pathology

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  • (PMID = 19704365.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neurofibromin 2
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32. Ramsden R, Khwaja S, Green K, O'Driscoll M, Mawman D: Vestibular schwannoma in the only hearing ear: cochlear implant or auditory brainstem implant? Otol Neurotol; 2005 Mar;26(2):261-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vestibular schwannoma in the only hearing ear: cochlear implant or auditory brainstem implant?
  • OBJECTIVE: To explore the dilemma faced by neurotologists confronted with the patient who develops a vestibular schwannoma in the only hearing ear, the other having been deaf from birth, and to consider the choice between auditory rehabilitation using a cochlear implant (CI) on the congenitally deaf side and an auditory brainstem implant (ABI) on the tumor side.
  • STUDY DESIGN: A record review of two patients born deaf in one ear and who developed a vestibular schwannoma in the contra lateral ear, who then received a CI in the congenitally deaf ear.
  • SETTING: Tertiary referral center with special experience in vestibular schwannoma surgery, neurofibromatosis type 2 management, and cochlear implantation.
  • [MeSH-major] Auditory Brain Stem Implantation. Cochlear Implantation. Deafness / congenital. Hearing Loss, Bilateral / rehabilitation. Neuroma, Acoustic / surgery. Postoperative Complications / rehabilitation

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  • (PMID = 15793416.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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33. Stieglitz LH, Samii A, Kaminsky J, Gharabaghi A, Samii M, Lüdemann WO: Nausea and dizziness after vestibular schwannoma surgery: a multivariate analysis of preoperative symptoms. Neurosurgery; 2005 Nov;57(5):887-90; discussion 887-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nausea and dizziness after vestibular schwannoma surgery: a multivariate analysis of preoperative symptoms.
  • OBJECTIVE: Nausea and dizziness are very discomforting for patients after vestibular schwannoma surgery and they impair recovery.
  • METHODS: To identify preoperative symptoms and conditions that increase the risk of development of nausea after vestibular schwannoma surgery, a multivariate analysis was performed.
  • One hundred fifteen patients with vestibular schwannoma had a microsurgical tumor removal in a standardized procedure in 2001 and 2002.
  • Eighteen patients were excluded from the study because of previous surgery (recurrent tumors, 7 patients) or bilateral tumor occurrence (neurofibromatosis, 11 patients).
  • Women with small tumors are most likely to develop significant complaints after vestibular schwannoma surgery.
  • CONCLUSION: It is possible to identify patients with a higher risk of postoperative nausea and dizziness after vestibular schwannoma surgery.
  • [MeSH-major] Dizziness / etiology. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / adverse effects. Postoperative Complications. Postoperative Nausea and Vomiting / etiology


34. Bouccara D, Kalamarides M, Bozorg Grayeli A, Ambert-Dahan E, Rey A, Sterkers O: [Auditory brainstem implant: indications and results]. Ann Otolaryngol Chir Cervicofac; 2007 Jul;124(3):148-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Implant auditif du tronc cérébral: indications et résultats.
  • Emergent indications are bilateral total ossified cochlea, vestibular schwannoma with controlateral lesions, cochlear nerve aplasia or inner ear's malformations.
  • RESULTS: In NF2 patients, best results are obtained in cases of smaller vestibular schwannoma and none, or short term, auditory deprivation.
  • [MeSH-minor] Brain / pathology. Calcinosis / etiology. Calcinosis / pathology. Cochlear Diseases / etiology. Cochlear Diseases / pathology. Cochlear Nerve / pathology. Cochlear Nerve / surgery. Electrodes, Implanted. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Neurofibromatosis 2 / complications. Neuroma, Acoustic / complications. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery

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  • (PMID = 17320034.001).
  • [ISSN] 0003-438X
  • [Journal-full-title] Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris
  • [ISO-abbreviation] Ann Otolaryngol Chir Cervicofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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35. Evans DG, Ramsden RT, Shenton A, Gokhale C, Bowers N, Huson SM, Wallace AJ: What are the implications in individuals with unilateral vestibular schwannoma and other neurogenic tumors? J Neurosurg; 2008 Jan;108(1):92-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] What are the implications in individuals with unilateral vestibular schwannoma and other neurogenic tumors?
  • OBJECTIVES: Individuals who develop a unilateral vestibular schwannoma (VS) and other neurogenic tumors are at high risk of having the inherited condition neurofibromatosis Type 2 (NF2).
  • The risk of bilateral disease and transmission risk to offspring are important in surgical planning and counseling.
  • METHODS: A large NF2 dataset was interrogated for individuals who had initially presented with a unilateral VS and other tumors before developing bilateral disease, to assess the contralateral and offspring risks.
  • [MeSH-major] Genes, Neurofibromatosis 2 / physiology. Mosaicism. Neuroma, Acoustic / genetics. Neuroma, Acoustic / pathology

  • Genetic Alliance. consumer health - Schwannoma.
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  • (PMID = 18173316.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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36. Harris GJ, Plotkin SR, Maccollin M, Bhat S, Urban T, Lev MH, Slattery WH: Three-dimensional volumetrics for tracking vestibular schwannoma growth in neurofibromatosis type II. Neurosurgery; 2008 Jun;62(6):1314-9; discussion 1319-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Three-dimensional volumetrics for tracking vestibular schwannoma growth in neurofibromatosis type II.
  • OBJECTIVE: Vestibular schwannomas (VS) are common, benign, VIIIth cranial nerve tumors.
  • Treatment in patients with the genetic disorder neurofibromatosis type II (NF2) is complicated by their development of bilateral VS and risk of complete deafness.
  • [MeSH-major] Imaging, Three-Dimensional. Magnetic Resonance Imaging. Neurofibromatosis 2 / pathology. Neuroma, Acoustic / pathology






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