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1. Sahu RN, Mehrotra N, Tyagi I, Banerji D, Jain VK, Behari S: Management strategies for bilateral vestibular schwannomas. J Clin Neurosci; 2007 Aug;14(8):715-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management strategies for bilateral vestibular schwannomas.
  • BACKGROUND: Bilateral vestibular schwannomas (VS) are rare.
  • Most patients in India present late in the course of illness with large tumors and disabling deafness.
  • AIMS: To highlight the differences in clinical presentations and surgical results of bilateral VS compared to unilateral VS; and, to propose a management strategy for these tumors with reference to tumor size, extent of growth and the presence or absence of hearing impairment.
  • Assessment of VIIth and VIIIth cranial nerve function, tumor size, volume and extent of growth was performed in all patients.
  • The management strategy was based on Samii's classification of tumor extent.
  • Headache with features of raised intracranial pressure were present in 10 (62.5%) patients.
  • Giant tumors were present in seven (43.7%) patients; large tumors in eight (50%) and a medium-sized tumor in one (6.3%).
  • Total tumor resection was achieved in 13 patients and subtotal resection in two.
  • On the contralateral side, one large tumor required total excision.
  • One medium sized tumor underwent sub-capsular excision in an attempt to preserve hearing.
  • The facial nerve was anatomically preserved in seven (46.7%) patients and in one, the cochlear nerve was anatomically preserved.
  • CONCLUSIONS: Patients with bilateral schwannomas are younger, have larger lesions, poorer preoperative hearing and are more likely to lose either auditory and/or facial nerve function during attempted total resection of the tumor.
  • Classifying the tumors into two groups by extent, that is, tumors extending to the cerebellopontine angle cistern (T1-T3a) and, tumors extending to or compressing the brainstem (T3b to T4b), allows the surgical strategy to be defined.
  • [MeSH-major] Cranial Nerve Neoplasms / therapy. Functional Laterality. Neuroma, Acoustic / therapy
  • [MeSH-minor] Adult. Cranial Nerves / physiopathology. Female. Hearing Disorders / etiology. Humans. Intracranial Pressure / physiology. Longitudinal Studies. Magnetic Resonance Imaging / methods. Male. Retrospective Studies. Tomography, X-Ray Computed / methods

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  • (PMID = 17577524.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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2. Prell J, Rampp S, Romstöck J, Fahlbusch R, Strauss C: Train time as a quantitative electromyographic parameter for facial nerve function in patients undergoing surgery for vestibular schwannoma. J Neurosurg; 2007 May;106(5):826-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Train time as a quantitative electromyographic parameter for facial nerve function in patients undergoing surgery for vestibular schwannoma.
  • OBJECT: The authors describe a quantitative electromyographic (EMG) parameter for intraoperative monitoring of facial nerve function during vestibular schwannoma removal.
  • This parameter is based on the automated detection of A trains, an EMG pattern that is known to be associated with postoperative facial nerve paresis.
  • During the entire operative procedure, free-running EMG signals were recorded in muscles targeted by the facial nerve.
  • A strong correlation between the length of train time (measured in seconds) and deterioration of postoperative facial nerve function was demonstrated.
  • Their transgression reliably indicated postoperative facial nerve paresis.
  • At less than a 10-second train time, discrete worsening, and at more than 10 seconds, profound deterioration of facial nerve function can be anticipated.
  • CONCLUSIONS: Train time as a quantitative parameter was shown to be a reliable indicator of facial nerve paresis after surgery for vestibular schwannoma.
  • [MeSH-major] Electromyography. Facial Nerve / physiopathology. Facial Paralysis / prevention & control. Monitoring, Intraoperative. Neuroma, Acoustic / surgery. Postoperative Complications / prevention & control. Signal Processing, Computer-Assisted

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  • (PMID = 17542526.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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3. Yomo S, Tamura M, Carron R, Porcheron D, Régis J: A quantitative comparison of radiosurgical treatment parameters in vestibular schwannomas: the Leksell Gamma Knife Perfexion versus Model 4C. Acta Neurochir (Wien); 2010 Jan;152(1):47-55
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  • [Title] A quantitative comparison of radiosurgical treatment parameters in vestibular schwannomas: the Leksell Gamma Knife Perfexion versus Model 4C.
  • The aim of this study was to investigate the impact of the PFX technology on the quality of dose planning for vestibular schwannomas (VS).
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / instrumentation

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  • (PMID = 19809786.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] Austria
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4. Mahrous AK, Kalepu R: Positive findings on MRI in patients with asymmetrical SNHL. Eur Arch Otorhinolaryngol; 2008 Dec;265(12):1471-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The pickup rate was 1% for CPA lesion which was vestibular schwannoma.

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  • (PMID = 18478244.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
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5. Yang J, Grayeli AB, Barylyak R, Elgarem H: Functional outcome of retrosigmoid approach in vestibular schwannoma surgery. Acta Otolaryngol; 2008 Aug;128(8):881-6
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  • [Title] Functional outcome of retrosigmoid approach in vestibular schwannoma surgery.
  • CONCLUSION: The retrosigmoid approach for small vestibular schwannomas (VS) yields a high rate of facial function preservation.
  • Hearing preservation rates depend on tumor size and preoperative hearing.
  • Hearing preservation appeared to be influenced by tumor size and preoperative hearing.
  • Multiple regression analysis of the preoperative factors influencing the hearing outcome showed that preoperative high frequency pure tone thresholds associated with tumor size were better correlated to postoperative pure tone average (PTA) than preoperative low frequencies.
  • [MeSH-major] Facial Nerve / physiopathology. Hearing / physiology. Neuroma, Acoustic / physiopathology. Neuroma, Acoustic / surgery

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  • (PMID = 18607969.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
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6. McClelland S 3rd, Gerbi BJ, Higgins PD, Orner JB, Hall WA: Safety and efficacy of fractionated stereotactic radiotherapy for acoustic neuromas. J Neurooncol; 2008 Jan;86(2):191-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Safety and efficacy of fractionated stereotactic radiotherapy for acoustic neuromas.
  • BACKGROUND: The treatment of acoustic neuromas (AN) has historically involved surgical excision or stereotactic radiosurgery, with a relatively limited number of reports available describing the use of fractionated stereotactic radiotherapy (FSRT).
  • Median tumor size (maximum diameter) was 2.1 cm (range, 1.1-3.4 cm).
  • RESULTS: Following FSRT, local tumor control was achieved in every patient, with the treatment well-tolerated by all patients.
  • No patient experienced acute complications or facial nerve weakness.
  • Two patients experienced permanent trigeminal nerve morbidity manifesting as facial numbness.
  • CONCLUSION: In our series of 20 patients with AN, all had local tumor control following FSRT, with minimal morbidity.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / methods. Stereotaxic Techniques
  • [MeSH-minor] Adult. Aged. Dose Fractionation. Female. Follow-Up Studies. Hearing Loss / etiology. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Radiography. Retrospective Studies. Treatment Outcome. Trigeminal Nerve / surgery

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  • (PMID = 17622486.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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7. Corona AP, Oliveira JC, Souza FP, Santana LV, Rêgo MA: Risk factors associated with vestibulocochlear nerve schwannoma: systematic review. Braz J Otorhinolaryngol; 2009 Jul-Aug;75(4):593-615
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Risk factors associated with vestibulocochlear nerve schwannoma: systematic review.
  • The vestibulocochlear nerve schwannoma (VS) is a benign tumor that stems from the edge of the Schwann s sheath.
  • It is considered the most frequent intracranial benign tumor, of low lethality rate and unknown etiology.
  • METHODS: electronic search of studies using the following key words: 'risk', 'schwannoma', 'vestibular', 'neuroma' and 'acoustic'.
  • [MeSH-major] Environmental Exposure / adverse effects. Neuroma, Acoustic / etiology

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  • (PMID = 19784431.001).
  • [ISSN] 1808-8686
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Brazil
  • [Number-of-references] 49
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8. MacNally SP, Rutherford SA, King AT, Freeman S, Thorne J, Mawman D, O'Driscoll MP, Evans DG, Ramsden RT: Outcome from surgery for vestibular schwannomas in children. Br J Neurosurg; 2009 Jun;23(3):226-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outcome from surgery for vestibular schwannomas in children.
  • OBJECT: A review of sporadic and NF2-related vestibular schwannoma surgery in children (under 18 years of age) with a specific interest in resection rates, recurrence, facial nerve outcomes, hearing preservation, hearing rehabilitation and genetic analysis.
  • METHODS: A retrospective analysis of prospectively collected data of 35 consecutively operated vestibular schwannomas in 29 paediatric patients that underwent 38 operations between 1992 and 2007.
  • Pre- and post-operative radiology, facial nerve function, pure tone audiogram and speech discrimination tests were performed with a mean follow-up of 4.5 years.
  • The facial nerve was anatomically preserved in 92%.
  • Facial nerve function was excellent to good (Grades 1-3) in 88% with outcome related to tumour size.
  • Hearing rehabilitation can be successful by utilising cochlear implants and auditory brain stem implants (ABI) as appropriate.
  • [MeSH-major] Facial Nerve. Neurofibromatosis 2 / surgery. Neuroma, Acoustic / surgery
  • [MeSH-minor] Adolescent. Auditory Brain Stem Implants. Auditory Threshold / physiology. Child. Cochlear Implants. Codon, Nonsense / genetics. Cranial Nerve Neoplasms / surgery. Facial Nerve Diseases / surgery. Female. Hearing Disorders / prevention & control. Humans. Male. Neoplasm Recurrence, Local / pathology. Outcome Assessment (Health Care). Postoperative Complications / prevention & control. Postoperative Complications / rehabilitation. Prognosis. Retrospective Studies. Speech Discrimination Tests

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  • [CommentIn] Br J Neurosurg. 2009 Jun;23(3):232-3 [19533455.001]
  • (PMID = 19533454.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Codon, Nonsense
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9. Rajaraman P, Schwartz BS, Rothman N, Yeager M, Fine HA, Shapiro WR, Selker RG, Black PM, Inskip PD: Delta-aminolevulinic acid dehydratase polymorphism and risk of brain tumors in adults. Environ Health Perspect; 2005 Sep;113(9):1209-11
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  • [Title] Delta-aminolevulinic acid dehydratase polymorphism and risk of brain tumors in adults.
  • The enzyme delta-aminolevulinic acid dehydratase (ALAD), which catalyzes the second step of heme synthesis, can be inhibited by several chemicals, including lead, a potential risk factor for brain tumors, particularly meningioma.
  • In this study we examined whether the ALAD G177C polymorphism in the gene coding for ALAD is associated with risk of intracranial tumors of the brain and nervous system.
  • We use data from a case-control study with 782 incident brain tumor cases and 799 controls frequency matched on hospital, age, sex, race/ethnicity, and residential proximity to the hospital.
  • ALAD genotype was determined for 94% of these samples (355 glioma, 151 meningioma, 67 acoustic neuroma, and 505 controls).
  • No increased risk associated with the ALAD2 variant was observed for glioma or acoustic neuroma.
  • [MeSH-major] Brain Neoplasms / genetics. Genetic Predisposition to Disease. Meningioma / genetics. Porphobilinogen Synthase / genetics

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  • (PMID = 16140629.001).
  • [ISSN] 0091-6765
  • [Journal-full-title] Environmental health perspectives
  • [ISO-abbreviation] Environ. Health Perspect.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Schwarz C, Dang Burgener NP, Dosso AA: [OCT Visante observation of the progression of a perforated neurotrophic cornea ulcer treated with amniotic membrane grafts]. J Fr Ophtalmol; 2008 Apr;31(4):419-21
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  • [Transliterated title] Observation à l'OCT Visante de l'évolution d'un ulcère cornéen neurotrophique perforant traité par greffes de membranes amniotiques.
  • METHODS: A 71-year-old patient with facial nerve paresis secondary to vestibular schwannoma surgery presented with a neurotrophic perforated corneal ulcer.
  • [MeSH-minor] Aged. Disease Progression. Humans. Male

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  • (PMID = 18563043.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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11. Fortnum H, O'Neill C, Taylor R, Lenthall R, Nikolopoulos T, Lightfoot G, O'Donoghue G, Mason S, Baguley D, Jones H, Mulvaney C: The role of magnetic resonance imaging in the identification of suspected acoustic neuroma: a systematic review of clinical and cost effectiveness and natural history. Health Technol Assess; 2009 Mar;13(18):iii-iv, ix-xi, 1-154
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  • [Title] The role of magnetic resonance imaging in the identification of suspected acoustic neuroma: a systematic review of clinical and cost effectiveness and natural history.
  • OBJECTIVE(S): To evaluate the clinical effectiveness and cost-effectiveness of a range of diagnostic strategies for investigating patients with unilateral hearing loss and/or tinnitus, with a view to confirming or eliminating a diagnosis of acoustic neuroma, and to describe the natural history of acoustic neuroma.
  • ABR has high sensitivity compared with MR imaging for acoustic neuromas greater than 1 cm in size but not for smaller neuromas.
  • Non-contrast-enhanced MR imaging was found to be a more cost-effective test for acoustic neuroma than GdT1W MR imaging.
  • The incidence of acoustic neuroma has increased over the last 30 years, with the median age at diagnosis remaining at 55 years.
  • The pattern and rate of growth of acoustic neuroma are highly variable and currently unpredictable.
  • Given the recent improvement in resolution and reduction in cost of MR imaging, ABR can no longer be considered appropriate as the primary test used to screen for acoustic neuroma.
  • Based on a cost-effectiveness model developed to reflect UK practice it was concluded that a diagnostic algorithm that deploys non-contrast MR imaging as an initial imaging screen in the investigation of acoustic neuroma is less costly than and likely to be as effective as available contrast MR imaging.
  • [MeSH-major] Neuroma, Acoustic / diagnosis. Neuroma, Acoustic / economics
  • [MeSH-minor] Age Distribution. Cost-Benefit Analysis. Evoked Potentials, Auditory, Brain Stem. Hearing Tests. Humans. Incidence. Magnetic Resonance Imaging. Prevalence. Reproducibility of Results. Technology Assessment, Biomedical

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  • (PMID = 19358774.001).
  • [ISSN] 2046-4924
  • [Journal-full-title] Health technology assessment (Winchester, England)
  • [ISO-abbreviation] Health Technol Assess
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 244
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12. Cross JJ, Baguley DM, Antoun NM, Moffat DA, Prevost AT: Reproducibility of volume measurements of vestibular schwannomas - a preliminary study. Clin Otolaryngol; 2006 Apr;31(2):123-9
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  • [Title] Reproducibility of volume measurements of vestibular schwannomas - a preliminary study.
  • OBJECTIVE: A preliminary study to investigate the intra-observer and inter-observer variability of measurements of vestibular schwannoma volume using an area-tracing and linear dimension measurement method.
  • SETTING: Ambulatory patients with known vestibular schwannoma attending a tertiary referral centre.
  • PARTICIPANTS: Twenty-three patients with 26 vestibular schwannomas aged 29-80 years old.
  • CONCLUSIONS: Volume measurements in vestibular schwannoma are variable even when the measurements are made by the same observer on identical images.
  • [MeSH-major] Neuroma, Acoustic / pathology

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  • (PMID = 16620331.001).
  • [ISSN] 1749-4478
  • [Journal-full-title] Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • [ISO-abbreviation] Clin Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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13. Friedman RA, Brackmann DE, Hitselberger WE, Schwartz MS, Iqbal Z, Berliner KI: Surgical salvage after failed irradiation for vestibular schwannoma. Laryngoscope; 2005 Oct;115(10):1827-32
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  • [Title] Surgical salvage after failed irradiation for vestibular schwannoma.
  • OBJECTIVES/HYPOTHESIS: Compare vestibular schwannoma (VS) surgical outcome between patients with prior irradiation and those not previously treated.
  • METHODS: Review of tumor adherence to the facial nerve, facial nerve grade, and complications in 38 patients with radiotherapy as a primary procedure before VS surgical removal and a matched random sample of 38 patients with primary surgery.
  • Mean tumor size at surgery was 2.6 cm in each group.
  • RESULTS: The irradiated group had more moderate to severe adherence of tumor than the controls (89% vs. 63%, P < or = .01).
  • [MeSH-major] Neuroma, Acoustic / radiotherapy. Neuroma, Acoustic / surgery. Otorhinolaryngologic Surgical Procedures

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  • (PMID = 16222204.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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14. Sakai T, Vallejo MC, Shannon KT: A parturient with neurofibromatosis type 2: anesthetic and obstetric considerations for delivery. Int J Obstet Anesth; 2005 Oct;14(4):332-5
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  • Neurofibromatosis type 2 is an extremely rare form of neurofibromatosis characterized by central nervous system involvement with bilateral vestibular schwannomas and spinal tumors.
  • Anesthetic management of a parturient with neurofibromatosis type 2 has not been fully reported, and the condition is challenging to obstetric anesthesiologists due to the presence of intracranial and intraspinal canal neurofibromas.


15. Springborg JB, Poulsgaard L, Thomsen J: Nonvestibular schwannoma tumors in the cerebellopontine angle: a structured approach and management guidelines. Skull Base; 2008 Jul;18(4):217-27
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  • [Title] Nonvestibular schwannoma tumors in the cerebellopontine angle: a structured approach and management guidelines.
  • The most common cerebellopontine angle (CPA) tumor is a vestibular schwannoma, but one in five CPA tumors are not vestibular schwannomas.
  • These tumors may require different management strategies.
  • Compared with vestibular schwannomas, symptoms and signs from cranial nerve VIII are less frequent: other cranial nerve and cerebellar symptoms and signs predominate in patients with these less common CPA tumors.
  • This review provides a structured approach to the diagnosis of nonvestibular schwannoma CPA lesions and also management guidelines.

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  • (PMID = 19119337.001).
  • [ISSN] 1531-5010
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2467479
  • [Keywords] NOTNLM ; Cerebellopontine angle / epidermoids / management guidelines / meningiomas / tumors
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16. Bennett M, Haynes DS: Surgical approaches and complications in the removal of vestibular schwannomas. Otolaryngol Clin North Am; 2007 Jun;40(3):589-609, ix-x
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  • [Title] Surgical approaches and complications in the removal of vestibular schwannomas.
  • Vestibular schwannomas are benign tumors that usually originate from the balance portion of cranial nerve VIII.
  • The treatment options currently available for vestibular schwannomas include observation with serial imaging, stereotactic radiation, and microsurgical removal.
  • Although the ultimate goal in treatment of vestibular schwannomas is preservation of life, the best option for each patient depends on symptoms, tumor size, tumor location, and the patient's general health and age.
  • Surgical exposure of the cerebellopontine angle for removal of vestibular schwannomas can be performed safely via a translabyrinthine, retrosigmoid, and middle fossa approach.
  • The goal of surgery is complete eradication of tumor with preservation of hearing and facial nerve function when possible.
  • [MeSH-major] Ear Neoplasms / surgery. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods
  • [MeSH-minor] Cerebrospinal Fluid Otorrhea / epidemiology. Cerebrospinal Fluid Otorrhea / etiology. Facial Nerve Diseases / epidemiology. Facial Nerve Diseases / etiology. Headache / epidemiology. Headache / etiology. Humans. Meningitis / epidemiology. Meningitis / etiology. Neoplasm Recurrence, Local. Postoperative Complications. Postural Balance / physiology. Tinnitus / epidemiology. Tinnitus / etiology

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  • (PMID = 17544697.001).
  • [ISSN] 0030-6665
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 33
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17. Coca Pelaz A, Rodrigo JP, Llorente JL, Gómez JR, Suárez C: [Unusual clinical presentations of vestibular schwannomas]. Acta Otorrinolaringol Esp; 2008 Apr;59(4):187-9
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  • [Title] [Unusual clinical presentations of vestibular schwannomas].
  • [Transliterated title] Formas clínicas inusuales de presentación de los neurinomas del acústico.
  • The aim of this study is evaluate the unusual ways of initial presentation of the vestibular schwannomas.
  • We performed a retrospective study of the patients who underwent resection of acoustic neuromas on our service, including for analysis only the cases which initial symptom was not the hearing loss.
  • Tumor size, localization, clinical presentation, and age of the patients were considered.
  • A significant group of patients did not present with the otological symptoms classically associated with vestibular schwannoma.
  • [MeSH-major] Cerebellopontine Angle / pathology. Hearing Loss / etiology. Neuroma, Acoustic / complications. Neuroma, Acoustic / pathology

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  • (PMID = 18447978.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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18. Chen S, Xu Y, Ou Y, Zheng Y, Deng Y, Chen B: [Endoscope-assisted surgical resection of acoustic neuroma]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 Aug;22(16):729-31
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  • [Title] [Endoscope-assisted surgical resection of acoustic neuroma].
  • OBJECTIVE: To explore the therapeutic efficacy and complications of endoscope-assisted surgical resection of acoustic neuroma.
  • METHOD: Assisted by hard-tube ear endoscope, 11 patients with acoustic neuroma were operated via labyrinthine approach and retrosigmoid approach.
  • CONCLUSION: The application of ear endoscope in acoustic neuroma surgery can improve the total removal rate of tumors and the salvage rate of vessels and nerves.
  • [MeSH-major] Endoscopy. Neuroma, Acoustic / surgery

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  • (PMID = 18975773.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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19. Menon G, Nair S, Sudhir J, Rao BR, Mathew A, Bahuleyan B: Childhood and adolescent meningiomas: a report of 38 cases and review of literature. Acta Neurochir (Wien); 2009 Mar;151(3):239-44; discussion 244
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  • Eleven children (28.9%) had evidence of NF of whom three had NF2 with bilateral vestibular schwannomas.
  • The common presenting symptoms were seizures (76.3%), raised intracranial tension (71%), and focal neurological deficits (39.4%).
  • The location of the operated tumours were as follows: ten skull base (24.4%), ten falx/parasagittal (24.4%), eight spinal (19.5%), five convexity (12.2%), three posterior fossa (7.3%), three intraventricular (7.3%) and two optic nerve sheath (4.9%).
  • [MeSH-minor] Adolescent. Age Factors. Child. Comorbidity. Dura Mater / pathology. Dura Mater / surgery. Female. Humans. Intracranial Hypertension / etiology. Male. Neoplasm Recurrence, Local / epidemiology. Neuroma, Acoustic / epidemiology. Neurosurgical Procedures. Optic Nerve / pathology. Retrospective Studies. Seizures / etiology. Skull Base Neoplasms / epidemiology. Skull Base Neoplasms / pathology. Skull Base Neoplasms / surgery. Spinal Neoplasms / epidemiology. Spinal Neoplasms / pathology. Spinal Neoplasms / surgery. Treatment Outcome

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  • (PMID = 19238320.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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20. Arriaga MA, Chen DA, Burke EL: Hydroxyapatite cement cranioplasty in translabyrinthine acoustic neuroma surgery-update. Otol Neurotol; 2007 Jun;28(4):538-40
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  • [Title] Hydroxyapatite cement cranioplasty in translabyrinthine acoustic neuroma surgery-update.
  • OBJECTIVE: To update the outcome of hydroxyapatite cement cranioplasty in translabyrinthine acoustic neuroma (TLAN) surgery.
  • [MeSH-major] Ear Neoplasms / surgery. Ear, Inner / surgery. Neuroma, Acoustic / surgery. Otologic Surgical Procedures

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  • (PMID = 17414174.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Bone Cements; 91D9GV0Z28 / Durapatite
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21. Hadfield KD, Smith MJ, Urquhart JE, Wallace AJ, Bowers NL, King AT, Rutherford SA, Trump D, Newman WG, Evans DG: Rates of loss of heterozygosity and mitotic recombination in NF2 schwannomas, sporadic vestibular schwannomas and schwannomatosis schwannomas. Oncogene; 2010 Nov 25;29(47):6216-21
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  • [Title] Rates of loss of heterozygosity and mitotic recombination in NF2 schwannomas, sporadic vestibular schwannomas and schwannomatosis schwannomas.
  • Biallelic inactivation of the NF2 gene occurs in the majority of schwannomas.
  • We have performed DNA sequence and dosage analysis of the NF2 gene in a panel of 239 schwannoma tumours: 97 neurofibromatosis type 2 (NF2)-related schwannomas, 104 sporadic vestibular schwannomas (VS) and 38 schwannomatosis-related schwannomas.
  • LOH was present in 28 out of 34 (82%) schwannomatosis-related schwannomas.
  • This study shows that MR is a mechanism of LOH in NF2 and SMARCB1-negative schwannomatosis-related schwannomas, occurring less frequently in sporadic vs. We found no evidence of MR in SMARCB1-positive schwannomatosis, suggesting that susceptibility to MR varies according to the disease context.
  • [MeSH-minor] Adolescent. Adult. Child. Chromosome Breakpoints. Gene Dosage / genetics. Genes, Neurofibromatosis 2. Homozygote. Humans. Neurilemmoma / genetics. Neurofibromatoses / genetics. Polymorphism, Single Nucleotide / genetics. Skin Neoplasms / genetics. Young Adult

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  • (PMID = 20729918.001).
  • [ISSN] 1476-5594
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] Schwannomatosis
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22. Wuertenberger CJ, Rosahl SK: Vertigo and tinnitus caused by vascular compression of the vestibulocochlear nerve, not intracanalicular vestibular schwannoma: review and case presentation. Skull Base; 2009 Nov;19(6):417-24
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  • [Title] Vertigo and tinnitus caused by vascular compression of the vestibulocochlear nerve, not intracanalicular vestibular schwannoma: review and case presentation.
  • Microvascular compression of the vestibulocochlear nerve is known to cause disabling tinnitus and vertigo.
  • The authors add the case of a 46-year-old man with venous compression of the vestibulocochlear nerve inside the internal auditory canal (IAC).
  • Magnetic resonance images showed a small, contrast-enhancing lesion in the fundus of the right IAC, which was suspicious for vestibular schwannoma.
  • During surgical exploration, a large venous loop was found extending into the IAC and compressing the vestibulocochlear nerve.
  • The presumed vestibular schwannoma at the cochlear fossa was left in situ.
  • On follow-up, there has been no growth of the contrast-enhancing lesion in the IAC for 3 years so far.Disabling vertigo can also be caused by venous microvascular compression of the vestibulocochlear nerve inside the IAC and may be treated successfully by microvascular decompression.
  • A sensitive, conservative approach to lesions in the fundus may be justified in the presence of an additional, more prominent pathology that causes compression of the vestibulocochlear nerve.

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  • (PMID = 20436843.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2793889
  • [Keywords] NOTNLM ; Acoustic neuroma / microvascular decompression / tinnitus / vertigo / vestibular schwannoma / vestibulocochlear nerve
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23. Koerbel A, Gharabaghi A, Samii A, Gerganov V, von Gösseln H, Tatagiba M, Samii M: Trigeminocardiac reflex during skull base surgery: mechanism and management. Acta Neurochir (Wien); 2005 Jul;147(7):727-32; discussion 732-3
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  • This phenomenon was defined as the onset of bradycardia lower than 60 beats/minute and hypotension with a drop in mean arterial blood pressure of 20% or more due to intra-operative manipulation or traction on the trigeminal nerve.
  • FINDINGS: Sixteen patients (8%) had a TCR intra-operatively (7 vestibular schwannomas, 5 sphenoid wing meningiomas, 3 petroclival meningiomas, 1 intracavernous epidermoid cyst).
  • CONCLUSIONS: Due to the intracranial course of the trigeminal nerve several surgical procedures at the anterior, middle and posterior skull base may elicit the trigeminocardiac reflex.
  • [MeSH-major] Bradycardia / physiopathology. Electrocardiography. Heart / innervation. Hypotension / physiopathology. Intraoperative Complications / physiopathology. Reflex, Oculocardiac / physiology. Skull Base / surgery. Skull Base Neoplasms / surgery. Trigeminal Nerve / physiopathology
  • [MeSH-minor] Adult. Aged. Cavernous Sinus / surgery. Craniotomy. Epidermal Cyst / surgery. Female. Heart Rate / physiology. Humans. Male. Meningeal Neoplasms / surgery. Meningioma / surgery. Middle Aged. Monitoring, Intraoperative. Neuroma, Acoustic / surgery

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  • (PMID = 15889318.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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24. Tashjian VS, Khanlou N, Vinters HV, Canalis RF, Becker DP: Hemangiopericytoma of the cerebellopontine angle: a case report and review of the literature. Surg Neurol; 2009 Sep;72(3):290-5
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  • BACKGROUND: Intracranial hemangiopericytoma represents a rare intracranial tumor that is typically difficult to distinguish from meningioma based on clinical presentation and radiographic findings.
  • These inherently aggressive neoplasms have been observed to occur in numerous intracranial compartments; however, isolated involvement of the CPA is essentially unreported.
  • The authors present a case of a young lady with presumed right acoustic schwannoma, which proved to be HPC on histopathology.
  • Magnetic resonance imaging demonstrated the presence of a homogeneously enhancing extraaxial lesion in the right CPA, radiographically suggestive of an acoustic schwannoma.
  • The lesion proved to be an intracranial HPC on histologic sections.
  • CONCLUSION: Given the fundamentally different treatment approach for HPCs over other more common CPA tumors, it is imperative that the treating surgeon consider this rare diagnosis when evaluating patients with lesions localized to this area.
  • Specifically, gross total resection, followed by adjuvant SRT, provides patients with the highest probability for disease-free survival, based on current evidence in the neurosurgical literature.
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Meningioma / diagnosis. Meningioma / surgery. Neoplasm Recurrence, Local / prevention & control. Positron-Emission Tomography. Radiotherapy, Adjuvant

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  • (PMID = 18786704.001).
  • [ISSN] 1879-3339
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 32
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25. Stojicic MT, Slavik EE, Acimovic GT, Jovanovic MD, Stojmirovic DM, Vujotic LD: Simultaneous surgical treatment of ulcer terebrans with intracranial propagation and acoustic neurinoma on the same side: a case report. J Plast Reconstr Aesthet Surg; 2008 Nov;61(11):e9-11
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  • [Title] Simultaneous surgical treatment of ulcer terebrans with intracranial propagation and acoustic neurinoma on the same side: a case report.
  • This article presents a successful surgical treatment of the patient with aggressive basal cell carcinoma with intracranial propagation (ulcer terebrans) and simultaneous acoustic neurinoma on the same side.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Neoplasms, Multiple Primary / surgery. Neuroma, Acoustic / surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Brain / pathology. Female. Humans. Magnetic Resonance Imaging. Meninges / pathology. Middle Aged. Neoplasm Invasiveness. Reconstructive Surgical Procedures / methods. Scalp / pathology

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  • (PMID = 18718834.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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26. Sánchez-Legaza E, Meléndez Guerrero B, Sánchez Legaza B, Idelfonso Miranda J: [Acoustic neurinoma shown as a facial palsy]. An Otorrinolaringol Ibero Am; 2007;34(6):565-72
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  • [Title] [Acoustic neurinoma shown as a facial palsy].
  • [Transliterated title] Neurinoma del acústico manifestado como una parálisis facial.
  • Acoustic neurinoma is the most frequent benign tumour at the cerebellopontile angle.
  • We present the case of a vestibular schwannoma in a pregnant lady diagnosed by a peripheral facial palsy.
  • [MeSH-major] Ear Neoplasms / diagnosis. Facial Paralysis / diagnosis. Neuroma, Acoustic / diagnosis

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  • (PMID = 18293776.001).
  • [ISSN] 0303-8874
  • [Journal-full-title] Anales otorrinolaringológicos ibero-americanos
  • [ISO-abbreviation] An Otorrinolaringol Ibero Am
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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27. Evans DG, Maher ER, Baser ME: Age related shift in the mutation spectra of germline and somatic NF2 mutations: hypothetical role of DNA repair mechanisms. J Med Genet; 2005 Aug;42(8):630-2
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  • We compared the ratio of frameshift to nonsense mutations in three diseases that are related to the NF2 tumour suppressor gene: classic neurofibromatosis 2 (NF2), caused by germline NF2 mutations; mosaic NF2; and unilateral sporadic vestibular schwannoma (USVS), caused by somatic NF2 inactivation.
  • [MeSH-minor] Age Factors. Genetic Predisposition to Disease. Humans. Mosaicism. Neuroma, Acoustic / genetics

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  • (PMID = 16061561.001).
  • [ISSN] 1468-6244
  • [Journal-full-title] Journal of medical genetics
  • [ISO-abbreviation] J. Med. Genet.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Codon, Nonsense
  • [Other-IDs] NLM/ PMC1736122
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28. Kabil MS, Shahinian HK: A series of 112 fully endoscopic resections of vestibular schwannomas. Minim Invasive Neurosurg; 2006 Dec;49(6):362-8
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  • [Title] A series of 112 fully endoscopic resections of vestibular schwannomas.
  • We report a consecutive series of 112 patients with unilateral vestibular schwannoma (VS) having undergone fully endoscopic resection of their tumors in the period from October, 2001 to January, 2005.
  • Patients' outcomes were evaluated especially with regards to cochlear nerve (hearing) preservation, facial nerve preservation, postoperative complications and completeness of the resection.
  • The patient population consisted of 112 consecutive cases with unilateral, "de novo" VS(s); patients with neurofibromatosis type 2 (NFT2) or with a recurrent tumor were excluded from this study.
  • Tumors ranged in size from 0.6-5.7 cm, most tumors were less than 3 cm in diameter (mean: 2.6 cm).
  • This shift towards smaller and also less symptomatic tumors may be due to an increase in the awareness of patients and earlier detection of their tumors (MRI era).
  • Tumors were removed via 1.5-cm "keyhole" retrosigmoid craniotomies.
  • Utilizing the fully endoscopic technique, 106/112 (95%) tumors were completely removed; subtotal removal was performed in 6/112 (5%) patients in an attempt to preserve their hearing.
  • Anatomic preservation of the facial nerve was achieved in all of the patients and of the cochlear nerve in 83/101 (82%) hearing ears.
  • There were no major neurological complications such as quadriparesis, hemiparesis, bacterial or aseptic meningitis, lower cranial nerve deficits, or deaths.
  • From our experience, we conclude that the endoscope is ideally suited for a minimally invasive approach for the resection of vestibular schwannomas.
  • [MeSH-major] Endoscopy. Neuroma, Acoustic / surgery

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  • (PMID = 17323265.001).
  • [ISSN] 0946-7211
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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29. Stieglitz LH, Samii A, Kaminsky J, Gharabaghi A, Samii M, Lüdemann WO: Nausea and dizziness after vestibular schwannoma surgery: a multivariate analysis of preoperative symptoms. Neurosurgery; 2005 Nov;57(5):887-90; discussion 887-90
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  • [Title] Nausea and dizziness after vestibular schwannoma surgery: a multivariate analysis of preoperative symptoms.
  • OBJECTIVE: Nausea and dizziness are very discomforting for patients after vestibular schwannoma surgery and they impair recovery.
  • METHODS: To identify preoperative symptoms and conditions that increase the risk of development of nausea after vestibular schwannoma surgery, a multivariate analysis was performed.
  • One hundred fifteen patients with vestibular schwannoma had a microsurgical tumor removal in a standardized procedure in 2001 and 2002.
  • Eighteen patients were excluded from the study because of previous surgery (recurrent tumors, 7 patients) or bilateral tumor occurrence (neurofibromatosis, 11 patients).
  • Tumor grading, body mass index, sex, previous complaints, examination at admission, and side of the tumor were taken in consideration.
  • Patients developing no significant postoperative complaints were all in the higher tumor grading group, Grades 3a, 4a, and 4b.
  • There was a significant difference in the duration of antiemetic therapy between tumors graded 1 and tumors graded 3 or 4.
  • Women with small tumors are most likely to develop significant complaints after vestibular schwannoma surgery.
  • CONCLUSION: It is possible to identify patients with a higher risk of postoperative nausea and dizziness after vestibular schwannoma surgery.
  • [MeSH-major] Dizziness / etiology. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / adverse effects. Postoperative Complications. Postoperative Nausea and Vomiting / etiology


30. Brackmann DE, Green JD Jr: Translabyrinthine approach for acoustic tumor removal. 1992. Neurosurg Clin N Am; 2008 Apr;19(2):251-64, vi
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  • [Title] Translabyrinthine approach for acoustic tumor removal. 1992.
  • It is the preferred approach for removal of all tumors in patients with poor hearing and for large tumors when the likelihood of hearing preservation is slight.
  • This approach offers the advantages of minimum cerebellar retraction, identification of the facial nerve proximally and medially, and the ability to repair immediately the facial nerve if it is severed during acoustic tumor removal.
  • [MeSH-major] Neuroma, Acoustic / history. Neurosurgical Procedures / history. Otologic Surgical Procedures / history

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  • (PMID = 18534338.001).
  • [ISSN] 1558-1349
  • [Journal-full-title] Neurosurgery clinics of North America
  • [ISO-abbreviation] Neurosurg. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Biography; Classical Article; Historical Article; Journal Article
  • [Publication-country] United States
  • [Personal-name-as-subject] Brackmann DE; Green JD Jr
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31. Denayer E, Brems H, de Cock P, Evans GD, Van Calenbergh F, Bowers N, Sciot R, Debiec-Rychter M, Vermeesch JV, Fryns JP, Legius E: Pathogenesis of vestibular schwannoma in ring chromosome 22. BMC Med Genet; 2009;10:97
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  • [Title] Pathogenesis of vestibular schwannoma in ring chromosome 22.
  • At the age of 20 years she was diagnosed with a unilateral vestibular schwannoma.
  • Genetic analysis of vestibular schwannoma tissue revealed loss of the ring chromosome 22 and a somatic second hit in the NF2 gene on the remaining chromosome 22.
  • [MeSH-major] Chromosomes, Human, Pair 22. Neuroma, Acoustic / genetics. Ring Chromosomes


32. Astner ST, Nieder C, Stock K, Gaa J, Grosu AL: Carcinomatous meningitis appearing as acoustic neuromas: two cases. Strahlenther Onkol; 2007 May;183(5):279-83
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  • [Title] Carcinomatous meningitis appearing as acoustic neuromas: two cases.
  • BACKGROUND: For acoustic neuromas, stereotactic radiotherapy (radiosurgery or stereotactic fractionated radiotherapy) has been established as an important alternative to microsurgery.
  • MRI scan shows a contrast-enhancing tumor within the inner auditory channel.
  • If medical history does not match with acoustic neuroma, further diagnostics are necessary to rule out infectious disease or carcinomatous meningitis.
  • CASE REPORT: Two patients with hearing loss, vertigo and the diagnosis of acoustic neuromas by MRI scan were referred for radiotherapy.
  • In both cases the symptoms progressed very rapidly, not typical of acoustic neuromas, and in both patients repeated liquor puncture finally revealed carcinomatous meningitis.
  • This is especially true for bilateral lesions suspicious for acoustic neuromas and rapid progression and persistence of clinical symptoms where carcinomatous meningitis has to be taken into account.
  • [MeSH-major] Esophageal Neoplasms / diagnosis. Meningeal Neoplasms / secondary. Neoplasms, Multiple Primary / diagnosis. Neuroma, Acoustic / diagnosis

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  • (PMID = 17497100.001).
  • [ISSN] 0179-7158
  • [Journal-full-title] Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
  • [ISO-abbreviation] Strahlenther Onkol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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33. Roche PH, Khalil M, Soumare O, Régis J: Hydrocephalus and vestibular schwannomas: considerations about the impact of gamma knife radiosurgery. Prog Neurol Surg; 2008;21:200-6
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  • [Title] Hydrocephalus and vestibular schwannomas: considerations about the impact of gamma knife radiosurgery.
  • Hydrocephalus may occur at various stages of the natural course of vestibular schwannoma and can also be diagnosed after the therapeutic procedure.
  • The aim of the present study was to analyze the impact of Gamma Knife radiosurgery (GKR) on previously diagnosed hydrocephalus (group A patients) and to evaluate the incidence of de novo hydrocephalus after GKR (group B patients).
  • Among the first 1,000 vestibular schwannoma patients treated by GKR in our institution, 30 patients (3%) belonged to group A and 1% to group B.
  • In both groups, hydrocephalus was more often associated with the following data: Elderly, large tumor, previous MS, NF2 disease and bilateral tumors.
  • De novo post-GKR hydrocephalus is of low incidence, comparable to the postoperative rate.
  • [MeSH-major] Hydrocephalus / epidemiology. Neuroma, Acoustic / surgery. Radiosurgery

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  • (PMID = 18810220.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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34. Bonneville F, Savatovsky J, Chiras J: Imaging of cerebellopontine angle lesions: an update. Part 2: intra-axial lesions, skull base lesions that may invade the CPA region, and non-enhancing extra-axial lesions. Eur Radiol; 2007 Nov;17(11):2908-20
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  • Computed tomography (CT) and magnetic resonance (MR) imaging reliably demonstrate typical features of vestibular schwannomas or meningiomas in the vast majority of mass lesions responsible for cerebellopontine angle (CPA) syndrome.
  • Finally, brain stem or ventricular tumours can present with a significant exophytic component in the CPA that may be difficult to differentiate from an extra-axial lesion (lymphoma, hemangioblastoma, choroid plexus papilloma, ependymoma, glioma, medulloblastoma, dysembryoplastic neuroepithelial tumour).
  • [MeSH-minor] Adult. Aged. Algorithms. Diagnosis, Differential. Diffusion Magnetic Resonance Imaging / methods. Female. Gadolinium / pharmacology. Humans. Male. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis. Middle Aged. Neoplasm Invasiveness. Neuroma, Acoustic / diagnosis

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  • (PMID = 17569053.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] AU0V1LM3JT / Gadolinium
  • [Number-of-references] 75
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35. Muscat JE, Hinsvark M, Malkin M: Mobile telephones and rates of brain cancer. Neuroepidemiology; 2006;27(1):55-6
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  • [Title] Mobile telephones and rates of brain cancer.
  • The risk of most primary brain cancers including gliomas and acoustic neuromas is unrelated to the use of mobile telephones in several studies.
  • An increased risk caused by short-term mobile phone use was reported for neuroepithelial tumors, a rare histologic subgroup of brain cancers that are characterized by neuronal features.
  • [MeSH-major] Brain Neoplasms / epidemiology. Cell Phones / utilization. Ganglioglioma / epidemiology

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  • (PMID = 16825795.001).
  • [ISSN] 0251-5350
  • [Journal-full-title] Neuroepidemiology
  • [ISO-abbreviation] Neuroepidemiology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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36. Ahlbom A, Feychting M, Green A, Kheifets L, Savitz DA, Swerdlow AJ, ICNIRP (International Commission for Non-Ionizing Radiation Protection) Standing Committee on Epidemiology: Epidemiologic evidence on mobile phones and tumor risk: a review. Epidemiology; 2009 Sep;20(5):639-52
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  • [Title] Epidemiologic evidence on mobile phones and tumor risk: a review.
  • This review summarizes and interprets epidemiologic evidence bearing on a possible causal relation between radiofrequency field exposure from mobile phone use and tumor risk.
  • In the last few years, epidemiologic evidence on mobile phone use and the risk of brain and other tumors of the head in adults has grown in volume, geographic diversity of study settings, and the amount of data on longer-term users.
  • Overall the studies published to date do not demonstrate an increased risk within approximately 10 years of use for any tumor of the brain or any other head tumor.
  • Despite the methodologic shortcomings and the limited data on long latency and long-term use, the available data do not suggest a causal association between mobile phone use and fast-growing tumors such as malignant glioma in adults (at least for tumors with short induction periods).
  • For slow-growing tumors such as meningioma and acoustic neuroma, as well as for glioma among long-term users, the absence of association reported thus far is less conclusive because the observation period has been too short.
  • [MeSH-major] Brain Neoplasms / etiology. Cell Phones. Glioma / etiology. Neoplasms, Radiation-Induced / etiology. Risk Assessment
  • [MeSH-minor] Brain / radiation effects. Humans. Research Design

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  • [CommentIn] Epidemiology. 2009 Sep;20(5):653-5 [19620872.001]
  • (PMID = 19593153.001).
  • [ISSN] 1531-5487
  • [Journal-full-title] Epidemiology (Cambridge, Mass.)
  • [ISO-abbreviation] Epidemiology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 48
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37. Raptis HA, Dannenbaum E, Paquet N, Feldman AG: Vestibular system may provide equivalent motor actions regardless of the number of body segments involved in the task. J Neurophysiol; 2007 Jun;97(6):4069-78
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  • [Title] Vestibular system may provide equivalent motor actions regardless of the number of body segments involved in the task.
  • To test this hypothesis, we compared the ability of healthy subjects and patients with unilateral vestibular lesions (surgical acoustic neuroma resection 0.6 to 6.7 yr before the study) to maintain either the same hand position or the same trajectory of within arm reach movements while flexing the trunk, in the absence of vision.
  • Results suggest that vestibular influences evoked by the head motion during trunk flexion play a major role in maintaining the consistency of arm motor actions in external space despite changes in the number of body segments involved.
  • Our findings also suggest that despite long-term plasticity in the vestibular system and related neural structures, unilateral vestibular lesion may reduce the capacity of the nervous system to achieve motor equivalence.
  • [MeSH-minor] Adult. Analysis of Variance. Electromyography. Female. Functional Laterality. Humans. Male. Middle Aged. Task Performance and Analysis. Upper Extremity / innervation. Vestibular Diseases / physiopathology

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  • (PMID = 17428903.001).
  • [ISSN] 0022-3077
  • [Journal-full-title] Journal of neurophysiology
  • [ISO-abbreviation] J. Neurophysiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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38. Browne JD, Fisch U: Transotic approach to the cerebellopontine angle. 1992. Neurosurg Clin N Am; 2008 Apr;19(2):265-78, vi
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  • The transotic approach to the cerebellopontine angle has been developed at the University of Zurich for the removal of acoustic tumors in an effort to increase operative exposure and enhance facial nerve preservation and reconstruction.
  • Key steps involve the total removal of all pneumatic cell tracts with middle ear and eustachian tube obliteration, followed by complete otic capsule removal for tumor exposure.
  • [MeSH-major] Cerebellar Neoplasms / history. Cerebellopontine Angle. Neuroma, Acoustic / history. Neurosurgical Procedures / history. Otologic Surgical Procedures / history

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  • (PMID = 18534339.001).
  • [ISSN] 1558-1349
  • [Journal-full-title] Neurosurgery clinics of North America
  • [ISO-abbreviation] Neurosurg. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Biography; Classical Article; Historical Article; Journal Article
  • [Publication-country] United States
  • [Personal-name-as-subject] Browne JD; Fisch U
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39. Smouha EE, Yoo M, Mohr K, Davis RP: Conservative management of acoustic neuroma: a meta-analysis and proposed treatment algorithm. Laryngoscope; 2005 Mar;115(3):450-4
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  • [Title] Conservative management of acoustic neuroma: a meta-analysis and proposed treatment algorithm.
  • OBJECTIVES/HYPOTHESES: Conservative management is a viable treatment alternative for acoustic neuroma.
  • METHODS: Published studies on conservative management of acoustic neuroma were found using a key word search through PubMed in addition to the bibliographies of these selected studies.
  • A spreadsheet was made to tabulate the selection criteria for conservative management, duration and frequency of follow-up, patient demographics, initial tumor size and rate of growth, change in hearing status, and the need for definitive treatment.
  • The average initial tumor size was 11.8 mm (n = 900); 43% of 1,244 acoustic neuromas showed growth, whereas 57% showed either no growth or tumor regression.
  • CONCLUSIONS: Our meta-analysis supports the role of conservative management of acoustic neuromas in properly selected patients on the basis of a slow overall rate of growth and a substantial incidence of no growth.
  • An algorithm for acoustic neuroma management is proposed based on initial tumor size, patient age, and hearing status.
  • [MeSH-major] Algorithms. Neuroma, Acoustic / therapy

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  • [CommentIn] Laryngoscope. 2005 Sep;115(9):1704; author reply 1704 [16148723.001]
  • (PMID = 15744156.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] United States
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40. Yang I, Sughrue ME, Han SJ, Aranda D, Pitts LH, Cheung SW, Parsa AT: A comprehensive analysis of hearing preservation after radiosurgery for vestibular schwannoma. J Neurosurg; 2010 Apr;112(4):851-9
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  • [Title] A comprehensive analysis of hearing preservation after radiosurgery for vestibular schwannoma.
  • OBJECT: Gamma Knife surgery (GKS) has evolved into a practical alternative to open microsurgical resection in the treatment of patients with vestibular schwannoma (VS).
  • To mitigate institutional and practitioner bias, the authors performed an analytical review of the published literature on the GKS treatment of vestibular schwannoma patients.
  • 3) documentation of initial tumor size; and 4) GKS was the only radiosurgical modality in the treatment.
  • Hearing preservation and outcome data were then aggregated and analyzed based on the radiation dose, tumor volume, and patient age.
  • RESULTS: The 45 articles that met the authors' inclusion criteria represented 4234 patients in whom an overall hearing preservation rate was 51%, irrespective of radiation dose, patient age, or tumor volume.
  • Patients with smaller tumors (average tumor volume < or = 1.5 cm(3)) had a hearing preservation rate (62%) comparable with patients harboring larger tumors (61%) (p = 0.8968).
  • Furthermore, larger tumors and older patients do not appear to be at any increased risk for hearing loss after GKS for VS than younger patients or patients with smaller tumors.
  • [MeSH-major] Hearing Loss / epidemiology. Neuroma, Acoustic / epidemiology. Neuroma, Acoustic / surgery. Postoperative Complications / epidemiology. Radiosurgery / adverse effects. Radiosurgery / statistics & numerical data


41. Cayé-Thomasen P, Borup R, Stangerup SE, Thomsen J, Nielsen FC: Deregulated genes in sporadic vestibular schwannomas. Otol Neurotol; 2010 Feb;31(2):256-66
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  • [Title] Deregulated genes in sporadic vestibular schwannomas.
  • OBJECTIVE: In search of genes associated with vestibular schwannoma tumorigenesis, this study examines the gene expression in human vestibular nerve versus vestibular schwannoma tissue samples using microarray technology.
  • MATERIAL AND METHODS: RNA was extracted from 3 vestibular nerves (serving as control) and 16 solid, sporadic vestibular schwannomas.
  • Differentially expressed genes were identified as differences between control and tumor tissue larger than 2-fold, with a conservative p value of less than 0.000161 and means of differences greater than 25.
  • RESULTS: Eighty-seven probe sets, representing 78 genes, were significantly up- or down-regulated in tumor tissue.
  • The deregulated genes were matched against established gene ontology, revealing that 8 of the up-regulated genes are involved in regulation of the cell cycle, 6 in cell morphogenesis, 8 in cell development, 11 in cell differentiation, 6 in cell death, 13 in cell adhesion, 9 in extracellular matrix, and 50 in protein binding (overlapping occurring).
  • Gene annotation enrichment analyses of the clustered genes showed significant enrichment of annotations for the extracellular matrix (p < 0.0002), cell adhesion (p < 0.0001), and protein binding (p < 0.0004).
  • CONCLUSION: We conclude that a number of transcripts are deregulated in sporadic vestibular schwannomas, and that several of these have functional annotations implicated in tumorigenesis.
  • Specifically, genes involved in extracellular matrix function, cell adhesion, and protein binding seem to be of potential importance.
  • [MeSH-major] Ear Neoplasms / genetics. Gene Expression Regulation, Neoplastic / genetics. Neuroma, Acoustic / genetics
  • [MeSH-minor] Adult. Aged. Apoptosis / genetics. Cell Adhesion / genetics. Cell Cycle / genetics. Cell Differentiation / genetics. Extracellular Matrix / genetics. Female. Humans. Male. Middle Aged. Morphogenesis / genetics. Oligonucleotide Array Sequence Analysis. Prospective Studies. RNA, Messenger / biosynthesis. RNA, Messenger / genetics. Vestibular Nerve / metabolism

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  • (PMID = 19816230.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger
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42. Yonekawa Y: [On the occasion of my retirement as head of the Neurochirurgische Universitätsklinik Zürich--changing aspects of treatment modality in modern neurosurgery and of neuroscience research. Presentation of our experience and historical backgrounds]. Brain Nerve; 2008 May;60(5):538-46
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  • Traditionally, carotid endarterectomy belonged to vascular surgeons in our hospital, but the tendency of conversion from conventional carotid endarterectomy to endovascular PTA and/or stenting seemed to be marked, while microvascular revascularization procedure represented by extracranial intracranial EC-IC bypass remained constant (around 20/year) in various occasion (277 times on 203 cases: atherosclerosis 93, Moyamoya angiopathy (MMA) 47, aneurysm 57 and skull base tumour 6, during the last 13 years], in spite of negative results of EC-IC bypass international cooperative study for stroke prevention in 1985.
  • Acoustic neurinoma (just less than 20/year) is one of benign brain tumours whose treatment has changed remarkably.
  • Thanks to development of intaroperative neurophysiological monitoring and of surgical technique, preservation of facial nerve function has improved from 60% to more than 85% in spite of the increase of size.
  • [MeSH-minor] Brain Neoplasms / surgery. Cerebral Revascularization / methods. Cerebral Revascularization / trends. Humans. Hydrocephalus / surgery. Intracranial Aneurysm / surgery. Intracranial Arteriovenous Malformations / surgery. Switzerland. Universities

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  • (PMID = 18516976.001).
  • [ISSN] 1881-6096
  • [Journal-full-title] Brain and nerve = Shinkei kenkyū no shinpo
  • [ISO-abbreviation] Brain Nerve
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 33
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43. Marouf R, Noudel R, Roche PH: Facial nerve outcome after microsurgical resection of vestibular schwannoma. Prog Neurol Surg; 2008;21:103-7
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  • [Title] Facial nerve outcome after microsurgical resection of vestibular schwannoma.
  • The risk of facial nerve palsy after microsurgical removal of vestibular schwannoma cannot be totally eradicated.
  • Taken together, the data from our personal experience and analysis of the literature indicate that the major predictor of postoperative facial deficit is tumor size.
  • When confronted with large tumors, we personally changed our surgical goals and considered that facial nerve conservation and tumor control are interconnected priorities instead of radical removal.
  • [MeSH-major] Facial Nerve Injuries / epidemiology. Facial Nerve Injuries / prevention & control. Facial Paralysis / epidemiology. Facial Paralysis / prevention & control. Microsurgery / adverse effects. Neuroma, Acoustic / surgery

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  • (PMID = 18810207.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 23
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44. Jeblaoui Y, Neji B, Haddad S, Mnif D, Hchicha S: [Difficulties of the management of head and neck neurofibromatosis]. Ann Chir Plast Esthet; 2007 Feb;52(1):43-50
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  • [Transliterated title] Difficultés de la prise en charge des atteintes de l'extrémité céphalique dans les neurofibromatoses.
  • Neurofibromatosis type 1 (NF1) or Von Recklinghausen's neurofibromatosis is an autosomal dominantly inherited disease, whose prevalence is 1/4500.
  • Neurofibromatosis type 2 (NF2) is also an autosomal dominantly inherited disease, but is ten times less frequent than the NF1 and is characterized by bilateral vestibular schwannomas (former acoustic neurinomas).
  • Surgical resection of the tumor was carried out among 8 patients with bone reconstruction of the orbit on 3 patients and cutaneous expansion on one other.
  • However, all our patients were satisfied with the result and we noted recurrence in a patient presenting a retro-auricular tumor, which filled the external auditory canal requiring a further surgery.
  • Cancer risks and the disease's completely unpredictable evolution urge a regular and multidisciplinary patient follow-up.

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  • (PMID = 17137698.001).
  • [ISSN] 0294-1260
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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45. Tufarelli D, Meli A, Alesii A, De Angelis E, Badaracco C, Falcioni M, Sanna M: Quality of life after acoustic neuroma surgery. Otol Neurotol; 2006 Apr;27(3):403-9
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  • [Title] Quality of life after acoustic neuroma surgery.
  • OBJECTIVE: The aim of this study is to assess patients' quality of life after acoustic neuroma surgery, and if some patients' characteristics, parameters of tumor and surgical parameters affect patients' quality of life.
  • PATIENTS: A group of 386 patients who underwent acoustic neuroma surgery.
  • INTERVENTION: Patients included were derived from a population of 459 subjects operated for acoustic neuroma by the Otologic Group of Piacenza.
  • Our data indicate that an early surgical approach for intrameatal tumor is better than waiting for an increase in the tumor size.
  • A "wait-and-scan" strategy for extrameatal neuromas which do not affect the brainstem is preferable, since these patients have a worsening of their quality of life after surgery independently of the tumor size.
  • [MeSH-major] Neuroma, Acoustic / surgery. Postoperative Complications / psychology. Quality of Life

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  • (PMID = 16639281.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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46. Smith MC, Ryken TC, Buatti JM: Radiotoxicity after conformal radiation therapy for benign intracranial tumors. Neurosurg Clin N Am; 2006 Apr;17(2):169-80, vii
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  • [Title] Radiotoxicity after conformal radiation therapy for benign intracranial tumors.
  • Acoustic schwannomas, skull base meningiomas, and pituitary adenomas are benign intracranial tumors frequently managed with radiotherapy.
  • Control rates after treatment for each of these tumors are generally high, and toxicity from treatment is relatively low.
  • Side effect profiles depend on the tumor location, the volume treated, the dose delivered, and the presence of nearby critical structures.
  • This article reviews radiotoxicity after conformal radiation therapy for acoustic schwannomas, skull base meningiomas, and pituitary adenomas.
  • [MeSH-major] Brain Neoplasms / radiotherapy. Neuroma, Acoustic / radiotherapy. Radiotherapy, Conformal / adverse effects

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  • (PMID = 16793508.001).
  • [ISSN] 1042-3680
  • [Journal-full-title] Neurosurgery clinics of North America
  • [ISO-abbreviation] Neurosurg. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 27
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47. Coelho DH, Roland JT Jr, Rush SA, Narayana A, St Clair E, Chung W, Golfinos JG: Small vestibular schwannomas with no hearing: comparison of functional outcomes in stereotactic radiosurgery and microsurgery. Laryngoscope; 2008 Nov;118(11):1909-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Small vestibular schwannomas with no hearing: comparison of functional outcomes in stereotactic radiosurgery and microsurgery.
  • OBJECTIVES: To date, numerous studies have compared functional outcomes between stereotactic radiosurgery (SRS) and microsurgery (MS) in the treatment of vestibular schwannomas (VS).
  • However, most of them involve tumors of difference sizes, radiation dosages, and surgical approaches.
  • By studying only patients with small tumors and no hearing, we sought to minimize confounding variables.
  • All MS patients underwent the translabyrinthine approach to their tumors.
  • Outcomes measurements included tumor control, facial nerve function, tinnitus, trigeminal function, and imbalance.
  • RESULTS: Patients undergoing SRS had comparable rates of tumor control, facial nerve function, tinnitus, and trigeminal function to MS patients.
  • CONCLUSIONS: In our study population, patients with small tumors and no serviceable hearing, these data suggest that MS results in comparable minimal morbidity with SRS, though posttreatment dysequilibrium is significantly decreased.
  • [MeSH-major] Facial Nerve / physiopathology. Hearing / physiology. Microsurgery / methods. Neuroma, Acoustic / physiopathology. Postural Balance / physiology. Radiosurgery / methods. Trigeminal Nerve / physiopathology

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  • (PMID = 18849856.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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48. Aihara N, Murakami S, Watanabe N, Takahashi M, Inagaki A, Tanikawa M, Yamada K: Cochlear nerve action potential monitoring with the microdissector in vestibular schwannoma surgery. Skull Base; 2009 Sep;19(5):325-32
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  • [Title] Cochlear nerve action potential monitoring with the microdissector in vestibular schwannoma surgery.
  • We developed a cochlear nerve action potential (CNAP) monitoring technique using a microdissector and compared the results of CNAP and auditory brainstem response (ABR) monitoring.
  • Thirty-six patients underwent vestibular schwannoma resection via the retrosigmoid approach to preserve hearing.
  • We used the microdissector as an intracranial electrode for CNAP monitoring.
  • At the completion of the tumor resection, the triphasic waveform was observed in 11 patients and the biphasic waveform was observed in 11 patients.

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  • (PMID = 20190942.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2765700
  • [Keywords] NOTNLM ; auditory brainstem response / cochlear nerve action potential / microdissector / vestibular schwannoma
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49. Peñarrocha-Diago M, Mora-Escribano E, Bagán JV, Peñarrocha-Diago M: Neoplastic trigeminal neuropathy: presentation of 7 cases. Med Oral Patol Oral Cir Bucal; 2006 Mar;11(2):E106-11
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  • We present 7 cases of trigeminal neuropathy secondary to tumors: in four cases there were antecedents of systemic neoplastic disease, while in the remaining three cases neuropathy was the first manifestation of the tumor.
  • The lesion was located in the mandible in three cases, in the region of the skull base in one patient, and in the brainstem and brain in one case each.
  • Recovery was only recorded in one patient in whom the symptoms were seen to disappear after acoustic nerve neurinoma resection.
  • The lesions underlying neoplastic trigeminal neuropathy can be located at any point along the trajectory of the trigeminal nerve, and their prognosis is very poor.
  • [MeSH-major] Cranial Nerve Neoplasms / complications. Cranial Nerve Neoplasms / diagnosis. Trigeminal Nerve Diseases / diagnosis. Trigeminal Nerve Diseases / etiology

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  • (PMID = 16505784.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Journal Article
  • [Publication-country] Spain
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50. Neff BA, Welling DB, Akhmametyeva E, Chang LS: The molecular biology of vestibular schwannomas: dissecting the pathogenic process at the molecular level. Otol Neurotol; 2006 Feb;27(2):197-208
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  • [Title] The molecular biology of vestibular schwannomas: dissecting the pathogenic process at the molecular level.
  • OBJECTIVE: The goal of this article was to review concisely what is currently known about the tumorigenesis of vestibular schwannomas.
  • BACKGROUND: Recent advances in molecular biology have led to a better understanding of the cause of vestibular schwannomas.
  • Mutations in the neurofibromatosis type 2 tumor suppressor gene (NF2) have been identified in these tumors.
  • In addition, the interactions of merlin, the protein product of the NF2 gene, and other cellular proteins are beginning to give us a better idea of NF2 function and the pathogenesis of vestibular schwannomas.
  • RESULTS: The clinical characteristics of vestibular schwannomas and neurofibromatosis type 2 syndromes are reviewed and related to alterations in the NF2 gene.
  • Studies demonstrating our current understanding of tumor developmental pathways are highlighted.
  • In addition, methods of clinical and genetic screening for neurofibromatosis type 2 disease are outlined.
  • CONCLUSION: Great strides have been made to identify why vestibular schwannomas develop at the molecular level.
  • Continued research is needed to find targeted therapies with which to treat these tumors.
  • [MeSH-major] Chromosomes, Human, Pair 22. Genes, Neurofibromatosis 2. Mutation. Neurofibromin 2 / genetics. Neuroma, Acoustic / genetics
  • [MeSH-minor] Alternative Splicing. Animals. Disease Models, Animal. Genetic Testing. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Mice. Promoter Regions, Genetic. RNA, Messenger / genetics. Signal Transduction / genetics

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  • (PMID = 16436990.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neurofibromin 2; 0 / RNA, Messenger
  • [Number-of-references] 114
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51. Boisson-Bertrand D, Laxenaire MC, Mertes PM: Recovery after prolonged anaesthesia for acoustic neuroma surgery: desflurane versus isoflurane. Anaesth Intensive Care; 2006 Jun;34(3):338-42
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  • [Title] Recovery after prolonged anaesthesia for acoustic neuroma surgery: desflurane versus isoflurane.
  • In this study, 33 patients were randomly assigned to receive desflurane (D) or isoflurane (I) for acoustic neuroma surgery.
  • The results indicate that desflurane is associated with similar operating conditions and faster postoperative recovery following acoustic neuroma surgery.
  • [MeSH-major] Anesthesia Recovery Period. Anesthesia, Inhalation. Anesthetics, Inhalation. Isoflurane / analogs & derivatives. Neuroma, Acoustic / surgery

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  • (PMID = 16802487.001).
  • [ISSN] 0310-057X
  • [Journal-full-title] Anaesthesia and intensive care
  • [ISO-abbreviation] Anaesth Intensive Care
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Anesthetics, Inhalation; CRS35BZ94Q / desflurane; CYS9AKD70P / Isoflurane
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52. Dumas G, De Waele C, Hamann KF, Cohen B, Negrevergne M, Ulmer E, Schmerber S: [Skull vibration induced nystagmus test]. Ann Otolaryngol Chir Cervicofac; 2007 Sep;124(4):173-83
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  • [Transliterated title] Le test vibratoire osseux vestibulaire.
  • Total unilateral peripheral lesions (tUVL: operated vestibular shwannomas, vestibular neurectomies) and partial unilateral peripheral lesions (pUVL: preoperative neuromas, Meniere's disease, vestibular neuritis, chemical labyrinthectomies) were studied.
  • SVINT is positive in 6 to 10% of the normal population, 31% of brain stem lesions and negative in total bilateral vestibular peripheral lesions.
  • CONCLUSIONS: SVINT is an effective, rapid and non invasive test used to detect vestibular asymmetry between 20 to 150 Hz stimulation.
  • SVINT is useful in the diagnosis of labyrinthine hydrops or detection of acoustic neuromas.
  • This test does not precisely point out the level of the lesion on the vestibular pathway.
  • [MeSH-minor] Adult. Aged. Caloric Tests. Edema / diagnosis. Edema / epidemiology. False Positive Reactions. Female. Humans. Male. Mastoid. Meniere Disease / diagnosis. Meniere Disease / epidemiology. Middle Aged. Neuroma, Acoustic / diagnosis. Neuroma, Acoustic / epidemiology. Prevalence. Sensitivity and Specificity. Severity of Illness Index. Skull / physiology. Vestibular Diseases / diagnosis. Vestibular Diseases / epidemiology. Vestibular Neuronitis / diagnosis. Vestibular Neuronitis / epidemiology

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  • (PMID = 17678612.001).
  • [ISSN] 0003-438X
  • [Journal-full-title] Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris
  • [ISO-abbreviation] Ann Otolaryngol Chir Cervicofac
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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53. Javadpour M: Management of vestibular schwannomas in children: a role for adult surgeons in the paediatric world? and the merits of centralisation? Br J Neurosurg; 2009 Jun;23(3):232-3
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  • [Title] Management of vestibular schwannomas in children: a role for adult surgeons in the paediatric world? and the merits of centralisation?
  • [MeSH-major] Facial Nerve / surgery. Neurofibromatosis 2 / surgery. Neuroma, Acoustic / surgery

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  • [CommentOn] Br J Neurosurg. 2009 Jun;23(3):226-31 [19533454.001]
  • (PMID = 19533455.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] England
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54. Scarlett A, Bird P, Macfarlane M: Conductive hearing loss after removal of acoustic neuroma. Otol Neurotol; 2008 Jun;29(4):553-6
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  • [Title] Conductive hearing loss after removal of acoustic neuroma.
  • OBJECTIVE: To report 4 patients who have developed a conductive and/or mixed hearing loss due to dehiscence of the inner ear after retrosigmoid approach for removal of acoustic neuroma.
  • PATIENTS: Four patients who presented with conductive and/or mixed hearing loss after retrosigmoid approach for removal of acoustic neuroma.
  • CONCLUSION: The occurrence of conductive hearing loss after the surgical removal of an acoustic neuroma has not previously been documented.
  • Computed tomographic scan of the temporal bones showing inner ear dehiscence may explain this finding.
  • [MeSH-major] Cranial Nerve Neoplasms / complications. Cranial Nerve Neoplasms / surgery. Hearing Loss, Conductive / etiology. Hearing Loss, Conductive / physiopathology. Neuroma, Acoustic / complications. Neuroma, Acoustic / surgery. Postoperative Complications / physiopathology. Vestibulocochlear Nerve Diseases / complications. Vestibulocochlear Nerve Diseases / surgery
  • [MeSH-minor] Acoustic Impedance Tests. Adult. Aged. Audiometry. Female. Hearing Aids. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Otologic Surgical Procedures. Otoscopy. Petrous Bone / pathology. Speech Perception. Tomography, X-Ray Computed


55. Browne S, Distel E, Morton RP, Petrie KJ: Patients' quality of life, reported difficulties, and benefits following surgery for acoustic neuroma. J Otolaryngol Head Neck Surg; 2008 Jun;37(3):417-22
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  • [Title] Patients' quality of life, reported difficulties, and benefits following surgery for acoustic neuroma.
  • OBJECTIVES: We compared the quality of life of patients with acoustic neuroma (AN) with general population controls and other chronic illness patients.
  • METHODS: A research questionnaire was sent to all 119 members of the Acoustic Neuroma Association of New Zealand.
  • However, most AN patients do report finding some benefit from their illness experience.
  • [MeSH-major] Hearing / physiology. Neuroma, Acoustic / psychology. Otologic Surgical Procedures / methods. Quality of Life

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  • (PMID = 19128648.001).
  • [ISSN] 1916-0216
  • [Journal-full-title] Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
  • [ISO-abbreviation] J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Canada
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56. Lahkola A, Tokola K, Auvinen A: Meta-analysis of mobile phone use and intracranial tumors. Scand J Work Environ Health; 2006 Jun;32(3):171-7
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  • [Title] Meta-analysis of mobile phone use and intracranial tumors.
  • OBJECTIVES: A summary of epidemiologic evidence regarding the effect of mobile phone use on intracranial tumor risk was obtained by means of a meta-analysis.
  • METHODS: Reports of published studies on mobile phone use and intracranial tumors were sought.
  • A pooled estimate was calculated for all intracranial tumors combined and also separately for different histological tumor types.
  • Separate analyses were conducted also based on the tumor location and type of mobile telephone network (NMT or GSM).
  • RESULTS: Twelve studies with 2780 cases gave a pooled odds ratio (OR) of 0.98 [95% confidence interval (95% CI) 0.83-1.16] for all intracranial tumors related to mobile phone use.
  • For gliomas, the pooled OR was 0.96 (95% CI 0.78-1.18), for meningiomas it was 0.87 (95% CI 0.72-1.05), and for acoustic neuromas it was 1.07 (95% CI 0.89-1.30).
  • Little indication was found for increased risks of analogue or digital phone use or temporal or occipital tumors.
  • CONCLUSIONS: The totality of evidence does not indicate a substantially increased risk of intracranial tumors from mobile phone use for a period of at least 5 years.
  • [MeSH-major] Brain Neoplasms / etiology. Cell Phones

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  • [CommentIn] Scand J Work Environ Health. 2006 Jun;32(3):169-70 [16804617.001]
  • (PMID = 16804618.001).
  • [ISSN] 0355-3140
  • [Journal-full-title] Scandinavian journal of work, environment & health
  • [ISO-abbreviation] Scand J Work Environ Health
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] Finland
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57. Morimoto Y, Sakabe T: [Auditory evoked potentials]. Masui; 2006 Mar;55(3):314-21
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  • Auditory evoked potentials (AEPs) are an electrical manifestation of the brain response to an auditory stimulus.
  • These waves are called the brain stem auditory evoked potentials (BAEPs) or the auditory brain stem response (ABR).
  • The BAEPs are useful during the microvascular decompression of the fifth or seventh cranial nerve, resection of acoustic neuroma and posterior fossa operations.
  • [MeSH-major] Evoked Potentials, Auditory. Evoked Potentials, Auditory, Brain Stem / physiology. Monitoring, Intraoperative / methods
  • [MeSH-minor] Anesthesia. Anesthetics / pharmacology. Auditory Pathways / physiology. Body Temperature. Brain Diseases / surgery. Humans. Reaction Time

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  • (PMID = 16541780.001).
  • [ISSN] 0021-4892
  • [Journal-full-title] Masui. The Japanese journal of anesthesiology
  • [ISO-abbreviation] Masui
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anesthetics
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58. Coez A, Zilbovicius M, Ferrary E, Bouccara D, Mosnier I, Ambert-Dahan E, Kalamarides M, Bizaguet E, Syrota A, Samson Y, Sterkers O: Processing of voices in deafness rehabilitation by auditory brainstem implant. Neuroimage; 2009 Oct 1;47(4):1792-6
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  • Profound acquired deafness by post-meningitis ossified cochlea and by bilateral vestibular schwannoma in neurofibromatosis type 2 patients are two indications for auditory brainstem implantation (ABI).
  • ABI allowed the transmission of sound stimuli to temporal brain regions but lacked transmitting the specific cues of the human voice to the TVA.
  • Moreover, among groups, during silent condition, brain visual regions showed higher rCBF in ABI group, although temporal brain regions had higher rCBF in the controls group.
  • [MeSH-major] Auditory Brain Stem Implantation / instrumentation. Auditory Cortex / physiology. Auditory Perception. Brain Mapping / methods. Deafness / physiopathology. Deafness / rehabilitation. Evoked Potentials, Auditory


59. Gerganov VM, Giordano M, Herold C, Samii A, Samii M: An electrophysiological study on the safety of the endoscope-assisted microsurgical removal of vestibular schwannomas. Eur J Surg Oncol; 2010 Apr;36(4):422-7
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  • [Title] An electrophysiological study on the safety of the endoscope-assisted microsurgical removal of vestibular schwannomas.
  • METHODS: We evaluated the risk of thermal or mechanical iatrogenic nerve injury related to endoscope application during microsurgical removal of vestibular schwannomas (VS) in a prospective group of 30 patients (Group A).
  • [MeSH-major] Endoscopy / methods. Microsurgery / methods. Neuroma, Acoustic / surgery

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  • [Copyright] Copyright (c) 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 19942394.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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60. Otto M, von Mühlendahl KE: Electromagnetic fields (EMF): do they play a role in children's environmental health (CEH)? Int J Hyg Environ Health; 2007 Oct;210(5):635-44
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  • Final results of the INTERPHONE study on the risk of brain tumours, acoustic neurinoma and parotid gland tumours associated with the use of mobile phones will be soon available.
  • [MeSH-minor] Cell Phones. Child. Humans. Leukemia, Radiation-Induced / etiology. Microwaves


61. Agrawal Y, Clark JH, Limb CJ, Niparko JK, Francis HW: Predictors of vestibular schwannoma growth and clinical implications. Otol Neurotol; 2010 Jul;31(5):807-12
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  • [Title] Predictors of vestibular schwannoma growth and clinical implications.
  • OBJECTIVE: Vestibular schwannomas exhibit variable and unpredictable patterns of growth.
  • We evaluated the extent to which tumor growth influences the management of these benign tumors, and we explored symptom markers present at diagnosis that may be predictive of tumor growth.
  • PATIENTS: One hundred eighty patients with unilateral vestibular schwannomas diagnosed between 1997 and 2007 who were initially managed conservatively by serial observation.
  • MAIN OUTCOME MEASURE(S): Tumor growth, defined as a 1 mm/year or greater increase in tumor size.
  • RESULTS: We observed that tumor growth was the most important predictor of a change in treatment strategy from serial observation to microsurgical or radiosurgical treatment.
  • We further noted in multivariate analyses that larger tumor size at diagnosis was associated with higher odds of tumor growth, such that each 1-mm increment in tumor size at presentation increased the odds of growth by 20%.
  • We also found that the symptom marker of tinnitus at diagnosis significantly increased the odds of tumor growth nearly 3-fold.
  • CONCLUSION: Tumor growth plays a significant role in guiding the management of vestibular schwannomas.
  • Assessment of tumor size at diagnosis and for the presence of tinnitus may allow for risk stratification of patients with newly diagnosed vestibular schwannomas and for a more rational application of the conservative management approach.
  • [MeSH-major] Ear Neoplasms / pathology. Neuroma, Acoustic / pathology

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  • (PMID = 20502379.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Hours M, Bernard M, Arslan M, Montestrucq L, Richardson L, Deltour I, Cardis E: Can loud noise cause acoustic neuroma? Analysis of the INTERPHONE study in France. Occup Environ Med; 2009 Jul;66(7):480-6
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  • [Title] Can loud noise cause acoustic neuroma? Analysis of the INTERPHONE study in France.
  • OBJECTIVES: To investigate possible associations between risk of acoustic neuroma and exposure to loud noise in leisure and occupational settings.
  • The cases were the 108 subjects diagnosed with acoustic neuroma between 1 June 2000 and 31 August 2003.
  • RESULTS: Acoustic neuroma was found to be associated with loud noise exposure (odds ratio (OR) = 2.55; 95% CI 1.35 to 4.82), both in leisure settings, particularly when listening to loud music (OR = 3.88; 95% CI 1.48 to 10.17) and at work (OR = 2.26; 95% CI 1.08 to 4.72).
  • CONCLUSION: The present results agree with other recent reports implicating loud noise in the risk of acoustic neuroma.
  • [MeSH-major] Environmental Exposure / adverse effects. Neuroma, Acoustic / etiology. Noise / adverse effects


63. Taoka T, Hirabayashi H, Nakagawa H, Sakamoto M, Myochin K, Hirohashi S, Iwasaki S, Sakaki T, Kichikawa K: Displacement of the facial nerve course by vestibular schwannoma: preoperative visualization using diffusion tensor tractography. J Magn Reson Imaging; 2006 Nov;24(5):1005-10
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  • [Title] Displacement of the facial nerve course by vestibular schwannoma: preoperative visualization using diffusion tensor tractography.
  • PURPOSE: To preoperatively visualize the course of the facial nerve, which is displaced by vestibular schwannoma, using diffusion tensor (DT) tractography, and to evaluate the agreement with surgical findings.
  • MATERIALS AND METHODS: The subjects were eight patients with vestibular schwannoma who had undergone removal surgery.
  • DT MR images were obtained and tracts that were considered to represent the facial nerve were constructed.
  • RESULTS: We obtained a tract that connected the internal auditory meatus and brainstem, and was considered to represent the facial nerve in seven of eight cases.
  • One exception was a case in which the tumor was too large to enable intraoperative observation of the facial nerve; however, the facial nerve appeared to be displaced anteriorly at intracapsular resection, in agreement with tractography.
  • In the other case, the schwannoma was mostly cystic.
  • We consider DT tractography to be a useful tool for preoperatively predicting facial nerve displacement in vestibular schwannoma.
  • [MeSH-major] Diffusion Magnetic Resonance Imaging / methods. Facial Nerve / pathology. Nerve Fibers, Myelinated / pathology. Neurilemmoma / pathology. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Surgery, Computer-Assisted / methods
  • [MeSH-minor] Adult. Aged. Facial Nerve Injuries / pathology. Facial Nerve Injuries / prevention & control. Female. Humans. Male. Middle Aged. Treatment Outcome

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  • [Copyright] Copyright (c) 2006 Wiley-Liss, Inc.
  • (PMID = 17031835.001).
  • [ISSN] 1053-1807
  • [Journal-full-title] Journal of magnetic resonance imaging : JMRI
  • [ISO-abbreviation] J Magn Reson Imaging
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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64. Goodwin L: Acoustic neuroma and radiosurgery. J Insur Med; 2007;39(1):44-6
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  • [Title] Acoustic neuroma and radiosurgery.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / methods. Treatment Outcome

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  • (PMID = 17500357.001).
  • [ISSN] 0743-6661
  • [Journal-full-title] Journal of insurance medicine (New York, N.Y.)
  • [ISO-abbreviation] J Insur Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Wenzel GI, Götz F, Lenarz T, Stöver T: HIV-associated cerebral lymphocyte infiltration mimicking vestibular schwannoma. Eur Arch Otorhinolaryngol; 2008 Dec;265(12):1567-71
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  • [Title] HIV-associated cerebral lymphocyte infiltration mimicking vestibular schwannoma.
  • The association of unilateral, rapidly progressive hearing loss, tinnitus and vestibular dysfunction in combination with a contrast-enhancing mass within the internal auditory canal on MRI is suggestive of a vestibular schwannoma (VS).
  • We report the rare finding of a HIV-associated cerebral lymphocyte infiltration, most probably malignant lymphoma, which was presumed initially to be a vs. A 36-year-old male presented with progressive unilateral hearing loss accompanied by acute, ipsilateral tinnitus.
  • Unilateral, rapidly progressive hearing loss and a fast growing cerebello-pontine mass is atypical for VS and highly suspicious of malignant disease.
  • [MeSH-major] Brain Neoplasms / diagnosis. HIV Infections / diagnosis. Lymphoma / diagnosis. Neuroma, Acoustic / diagnosis

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  • (PMID = 18317791.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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66. Müller S, Arnolds J, van Oosterhout A: Decision-making of vestibular schwannoma patients. Acta Neurochir (Wien); 2010 Jun;152(6):973-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Decision-making of vestibular schwannoma patients.
  • BACKGROUND: Patients suffering from vestibular schwannoma can choose between four modalities of management:.
  • METHOD: This study is based on postal questionnaire survey of 739 vestibular schwannoma patients (survey response rate, 78%).
  • CONCLUSION: The praxis of patient counselling of acoustic neuroma patients in Germany is far from the ideal condition of medical consultation: The most important shortcoming is that it is unilateral: About 69% of the patients are informed about only one treatment option, generally surgery.
  • [MeSH-major] Decision Making. Dose Fractionation. Neuroma, Acoustic / radiotherapy. Neuroma, Acoustic / surgery. Patient Participation. Radiosurgery

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  • (PMID = 20169371.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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67. Yates CW, Weinberg M, Packer MJ, Jacob A: Fatal case of tumor-associated hemorrhage in a large vestibular schwannoma. Ann Otol Rhinol Laryngol; 2010 Jun;119(6):402-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fatal case of tumor-associated hemorrhage in a large vestibular schwannoma.
  • Vestibular schwannomas are benign neoplasms that arise from Schwann cells of the eighth cranial nerve.
  • Most manifest clinically with tinnitus, unilateral sensorineural hearing loss, and dysequilibrium secondary to compression of the vestibulocochlear nerve; major adverse events such as intratumoral hemorrhage causing acute neurologic deterioration are rare.
  • We report the case of a 69-year-old man with a large vestibular schwannoma who required anticoagulation for several medical comorbidities.
  • The patient began having progressively worsening neurologic symptoms, including facial nerve paralysis and dysequilibrium, which confined him to a wheelchair.
  • Several days after alteration of his anticoagulation therapy in preparation for surgery, he developed intracranial hemorrhage.
  • Attempts were made to stabilize the patient, including posterior fossa craniectomy and evacuation of hematoma; however, the intracranial hemorrhage ultimately resulted in a fatal outcome.
  • During this procedure, a biopsy specimen was obtained, showing benign vestibular schwannoma.
  • The literature for intratumoral hemorrhage into vestibular schwannoma and the pathologic findings in our case are reviewed.
  • [MeSH-major] Intracranial Hemorrhages / etiology. Neuroma, Acoustic / complications
  • [MeSH-minor] Aged. Anticoagulants / therapeutic use. Comorbidity. Disease Progression. Fatal Outcome. Heart Valve Prosthesis. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Retrospective Studies. Warfarin / therapeutic use

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  • (PMID = 20583739.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticoagulants; 5Q7ZVV76EI / Warfarin
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68. Massager N, Nissim O, Delbrouck C, Devriendt D, David P, Desmedt F, Wikler D, Hassid S, Brotchi J, Levivier M: Role of intracanalicular volumetric and dosimetric parameters on hearing preservation after vestibular schwannoma radiosurgery. Int J Radiat Oncol Biol Phys; 2006 Apr 1;64(5):1331-40
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  • [Title] Role of intracanalicular volumetric and dosimetric parameters on hearing preservation after vestibular schwannoma radiosurgery.
  • PURPOSE: To analyze the relationship between hearing preservation after gamma knife radiosurgery (GKR) for vestibular schwannoma (VS) and some volumetric and dosimetric parameters of the intracanalicular components of vs. METHODS AND MATERIALS: This study included 82 patients with a VS treated by GKR; all patients had no NF2 disease, a Gardner-Robertson hearing class 1-4 before treatment, a marginal dose of 12 Gy, and a radiologic and audiologic follow-up > or =1 year post-GKR.
  • The volume of both the entire tumor and the intracanalicular part of the tumor and the mean and integrated dose of these two volumes were correlated to the auditory outcomes of patients.
  • We found that hearing preservation after GKR is significantly correlated with the intracanalicular tumor volume, as well as with the integrated dose delivered to the intracanalicular tumor volume.
  • CONCLUSIONS: Some volumetric and dosimetric parameters of the intracanalicular part of the tumor influence hearing preservation after GKR of vs. Consequently, we advise the direct treatment of patients with preserved functional hearing and a VS including a small intracanalicular volume.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery

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  • (PMID = 16458446.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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69. Chen CC, Cheng PW, Tseng HM, Young YH: Posterior cranial fossa tumors in young adults. Laryngoscope; 2006 Sep;116(9):1678-81
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  • [Title] Posterior cranial fossa tumors in young adults.
  • OBJECTIVE/HYPOTHESIS: This retrospective study presents our experience on the posterior cranial fossa tumors in young adults during the past 15 years.
  • METHODS: From 1991 to 2005, 16 (0.8%) of 2,091 young adults (range, 16-29 years) with dizziness/vertigo, hearing loss, or tinnitus were diagnosed with posterior fossa tumor.
  • Diagnoses consisted of vestibular schwannoma and neurofibromatosis II in eight patients (50%), glial neoplasm (including astrocytoma, ependymoma, glioma) in four patients (25%), epidermoid cyst in three patients, and glomus jugulare tumor in one patient.
  • At study close, excluding one lost patient, three patients died as a result of recurrent or residual tumor at the primary site.
  • CONCLUSIONS: Unlike predominant medulloblastoma in children, the most frequent posterior fossa tumor in young adults is vestibular schwannoma and neurofibroma.
  • However, the second most frequent one in young adults is glial neoplasm as opposed to meningioma in adults.

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  • (PMID = 16955003.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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70. Kameda K, Shono T, Hashiguchi K, Yoshida F, Sasaki T: Effect of tumor removal on tinnitus in patients with vestibular schwannoma. J Neurosurg; 2010 Jan;112(1):152-7
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  • [Title] Effect of tumor removal on tinnitus in patients with vestibular schwannoma.
  • OBJECT: Tinnitus is one of the most common symptoms in patients with vestibular schwannomas (VSs), but the effect of surgery on this symptom has not been fully evaluated.
  • The aim of this study was to define the effect on tinnitus of tumor removal, cochlear nerve resection, and useful hearing preservation in patients with VSs.
  • RESULTS: Of 242 patients, 171 (70.7%) complained of tinnitus before surgery; the symptom disappeared in 25.2%, improved in 33.3%, remained unchanged in 31.6%, and worsened in 9.9% of these cases after tumor removal.
  • In the 171 patients with preoperative tinnitus, the cochlear nerve was resected in 85 (49.7%) and preserved in 86 (50.3%), but there was no significant difference in the incidence of postoperative tinnitus between these 2 groups (p = 0.293).
  • Among those without preoperative tinnitus, the cochlear nerve was resected in 45 cases (63.4%) and tinnitus appeared postoperatively in 3 (6.7%).
  • CONCLUSIONS: Tumor removal via the retrosigmoid lateral suboccipital approach may provide some chance for improvement of tinnitus in patients with VSs; however, neither cochlear nerve resection nor useful hearing preservation affects the postoperative development of tinnitus.
  • [MeSH-major] Neuroma, Acoustic / complications. Neuroma, Acoustic / surgery. Tinnitus / etiology. Tinnitus / surgery
  • [MeSH-minor] Cochlear Nerve / surgery. Female. Hearing Disorders / etiology. Humans. Male. Middle Aged. Retrospective Studies. Severity of Illness Index. Treatment Outcome


71. Hasegawa T, Kida Y, Yoshimoto M, Koike J, Goto K: Evaluation of tumor expansion after stereotactic radiosurgery in patients harboring vestibular schwannomas. Neurosurgery; 2006 Jun;58(6):1119-28; discussion 1119-28
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  • [Title] Evaluation of tumor expansion after stereotactic radiosurgery in patients harboring vestibular schwannomas.
  • OBJECTIVE: Stereotactic radiosurgery has been accepted as a safe and effective treatment in patients harboring a vestibular schwannoma.
  • However, during follow-up, tumor expansion induced by high-dose irradiation can occur.
  • Tumor expansion is more likely to be transient, but this phenomenon causes some confusion regarding whether further treatment should be performed.
  • Our purpose was to clarify what type of tumor expansion requires additional treatment.
  • METHODS: Between May 1991 and December 1998, 346 patients with a vestibular schwannoma, excluding two with neurofibromatosis, were treated using gamma knife radiosurgery.
  • Of these, serial follow-up images to evaluate tumor expansion were available for 254 patients.
  • Tumor expansion was classified into three types: central necrosis (Type A), solid expansion (Type B), and cyst enlargement or formation (Type C).
  • RESULTS: Forty-two patients (17%) had tumor expansion during follow-up.
  • CONCLUSION: Although tumor expansion was more likely to be transient, additional treatments should be considered in patients who experience neurological deterioration.
  • We strongly recommend simply waiting and obtaining frequent follow-up images until the patients experience neurological deterioration, even when tumor expansion is developing, excluding cyst formation, which tends to continue.
  • [MeSH-major] Magnetic Resonance Imaging. Neuroma, Acoustic / diagnosis. Neuroma, Acoustic / surgery. Radiosurgery / adverse effects

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  • (PMID = 16723891.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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72. Plotkin SR, Singh MA, O'Donnell CC, Harris GJ, McClatchey AI, Halpin C: Audiologic and radiographic response of NF2-related vestibular schwannoma to erlotinib therapy. Nat Clin Pract Oncol; 2008 Aug;5(8):487-91
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  • [Title] Audiologic and radiographic response of NF2-related vestibular schwannoma to erlotinib therapy.
  • INVESTIGATIONS: Medical and neurological examination, MRI scan of the brain and spinal cord, pure-tone audiometry, NU-6 monosyllabic word test with phoneme scoring, City University of New York topic-related sentences test, noise/voice test of minimal auditory capability battery.
  • DIAGNOSIS: Progressive neurofibromatosis-type-2-related vestibular schwannomas.
  • MANAGEMENT: Annual cranial MRI and audiology, surgical resection of right vestibular schwannoma, high-power behind-the-ear hearing aid, erlotinib therapy for progressive left vestibular schwannoma.
  • [MeSH-minor] Audiometry, Pure-Tone. Auditory Threshold. Combined Modality Therapy. Erlotinib Hydrochloride. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Protein Kinase Inhibitors / administration & dosage. Treatment Outcome. Vestibular Diseases / complications. Vestibular Diseases / drug therapy. Vestibular Diseases / surgery

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  • (PMID = 18560388.001).
  • [ISSN] 1743-4262
  • [Journal-full-title] Nature clinical practice. Oncology
  • [ISO-abbreviation] Nat Clin Pract Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Protein Kinase Inhibitors; 0 / Quinazolines; DA87705X9K / Erlotinib Hydrochloride
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73. Roche PH, Ribeiro T, Fournier HD, Thomassin JM: Vestibular schwannomas: complications of microsurgery. Prog Neurol Surg; 2008;21:214-21
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  • [Title] Vestibular schwannomas: complications of microsurgery.
  • Current microsurgical treatment of vestibular schwannomas usually brings satisfactory results for the patients.
  • However, transient or permanent complications may occur, especially when treating large tumors.
  • Based on their personal experience of large operated vestibular schwannomas and analyzing a review of the international literature, the authors detail these complications and the way to prevent and manage them.
  • Lower cranial nerve deficits are unusual but may expose to early and delayed aspiration pneumonias.
  • [MeSH-major] Microsurgery / adverse effects. Neuroma, Acoustic / surgery
  • [MeSH-minor] Cerebrovascular Disorders / etiology. Cranial Nerve Diseases / etiology. Craniotomy / adverse effects. Humans. Meningitis / etiology

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  • (PMID = 18810222.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 18
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74. Cadoni G, Cianfoni A, Agostino S, Scipione S, Tartaglione T, Galli J, Colosimo C: Magnetic resonance imaging findings in sudden sensorineural hearing loss. J Otolaryngol; 2006 Oct;35(5):310-6
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  • METHODS: Fifty-four consecutive patients affected by SSNHL were investigated using brain MRI.
  • MRI was performed with an eight-channel phased-array head coil to study the entire audiovestibular pathway and the whole brain.
  • The rest of the brain was studied with a 4 mm axial T(2)-weighted FLAIR sequence.
  • In 6 of 54 cases, the detected abnormality was directly correlated to the clinical picture (2 labyrinthine hemorrhage, 1 cochlear inflammation, 1 acoustic neuroma, 1 arachnoid cyst of the CPA, and 1 case of white matter lesions in the pons, compatible with demyelinating plaques along the central audiovestibular nervous pathway, as the first expression of multiple sclerosis).
  • CONCLUSIONS: An extensive MRI study of the audiovestibular nervous pathway and of the whole brain, pre- and postparamagnetic contrast administration, is recommended to rule out the wide spectrum of abnormalities that can cause SSNHL.
  • [MeSH-minor] Adult. Aged. Arachnoid Cysts / pathology. Audiometry, Pure-Tone. Brain / pathology. Cerebellum / blood supply. Cochlea / pathology. Female. Gadolinium. Humans. Male. Middle Aged. Multiple Sclerosis / pathology. Neuroma, Acoustic / pathology

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  • (PMID = 17049147.001).
  • [ISSN] 0381-6605
  • [Journal-full-title] The Journal of otolaryngology
  • [ISO-abbreviation] J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] AU0V1LM3JT / Gadolinium
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75. Goutagny S, Bouccara D, Bozorg-Grayeli A, Sterkers O, Kalamarides M: [Neurofibromatosis type 2]. Rev Neurol (Paris); 2007 Sep;163(8-9):765-77
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  • [Transliterated title] La neurofibromatose de type 2.
  • INTRODUCTION: Neurofibromatosis 2 (NF2) is a rare autosomal dominant disease whose hallmark is the development of bilateral vestibular schwannomas.
  • STATE OF THE ART: Other features of NF2 include schwannomas, meningiomas, ependymomas, localized along the central nervous system, schwannomas of the peripheral nerves, cutaneous and ophthalmological manifestations.
  • NF2 can be diagnosed in patients without bilateral vestibular schwannoma with sets of diagnostic criteria.
  • Disease phenotype is variable among patients.
  • Main negative prognostic factors are a young age at onset of symptoms and a high number of tumors at diagnosis.
  • NF2 tumor suppressor gene encodes Merlin/Schwannomin, and is also involved in most sporadic schwannomas and meningiomas.
  • Some authors advocate an early proactive strategy against vestibular schwannoma in order to preserve hearing.
  • When a treatment is advisable, surgery remains the treatment of choice for tumors.
  • [MeSH-minor] Adolescent. Adult. Brain Neoplasms / genetics. Brain Neoplasms / pathology. Child. Child, Preschool. Diagnosis, Differential. Ependymoma / epidemiology. Ependymoma / genetics. Ependymoma / pathology. Female. Genes, Tumor Suppressor. Humans. Male. Middle Aged. Neurilemmoma / genetics. Neurilemmoma / pathology. Prognosis

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  • (PMID = 17878803.001).
  • [ISSN] 0035-3787
  • [Journal-full-title] Revue neurologique
  • [ISO-abbreviation] Rev. Neurol. (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 65
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76. Hirvonen M, Aalto H, Hirvonen TP: Postural control after vestibular schwannoma resection measured with visual feedback posturography. ORL J Otorhinolaryngol Relat Spec; 2005;67(6):335-9
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  • [Title] Postural control after vestibular schwannoma resection measured with visual feedback posturography.
  • BACKGROUND: Vestibular symptoms after surgery diminish rapidly, but the simultaneous progress in active postural control has not been fully addressed.
  • OBJECTIVES: The aim was to evaluate the progress in postural control in operated vestibular schwannoma (VS) patients with visual feedback posturography (VFP).
  • CONCLUSIONS: The VFP is an objective and repeatable method, which can be used to assess and follow up the active postural control in individual patients with vs. Persisting abnormality in the VFP seems to be an indication for more aggressive vestibular rehabilitation to normalize the disturbed postural control.
  • [MeSH-major] Biofeedback, Psychology. Neuroma, Acoustic / surgery. Photic Stimulation / instrumentation. Posture. Visual Perception

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  • (PMID = 16327273.001).
  • [ISSN] 0301-1569
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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77. Tong MC, Lam JM, Hu BH, Sanna M: [Clinical experience in 36 cases of using of the extended translabyrinthine technique for the treatment of large acoustic neuromas]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2005 Sep;40(9):705-7
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  • [Title] [Clinical experience in 36 cases of using of the extended translabyrinthine technique for the treatment of large acoustic neuromas].
  • [MeSH-major] Fenestration, Labyrinth / methods. Neuroma, Acoustic / surgery

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  • (PMID = 16335411.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Journal Article
  • [Publication-country] China
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78. Xu J, Huang W, Liu G, Zhou J, Gao B: [Patterns of hearing disorders in normal otoacoustic emissions]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2005 Nov;19(22):1023-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHOD: Tests of pure tone audiometry, acoustic impedance test, auditory brainstem response (ABR), 40 Hz AERP,spontaneous otoacoustic emissions (SOAE), transient evoked otoacoustic emissions (TEOAE), distortion evoked otoacoustic emissions (DPEOAE)and imaging examinations of CT/MRI scan were performed on all 83 patients with hearing disorders.
  • (2) 2 patients with unilateral acoustic neuroma;.

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  • (PMID = 16468152.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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79. Yamaguchi S, Kato T, Takeda M, Ikeda H, Kitamura K: Ruptured distal anterior inferior cerebellar artery aneurysm following stereotactic irradiation for vestibular schwannoma: case report. Neurol Med Chir (Tokyo); 2009 May;49(5):202-5
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  • [Title] Ruptured distal anterior inferior cerebellar artery aneurysm following stereotactic irradiation for vestibular schwannoma: case report.
  • Six years before admission, she had undergone stereotactic irradiation for right vestibular schwannoma, under a diagnosis based on neuroimaging.
  • Long-term surviving patients who have received intracranial irradiation should undergo sequential follow up for possible vascular involvement.
  • [MeSH-major] Aneurysm, Ruptured / etiology. Intracranial Aneurysm / etiology. Neuroma, Acoustic / radiotherapy. Radiation Injuries / etiology

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  • (PMID = 19465790.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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80. Gönül E, Izci Y, Onguru O: Arachnoid cyst of the cerebellopontine angle associated with gliosis of the eighth cranial nerve. J Clin Neurosci; 2007 Jul;14(7):700-2
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  • [Title] Arachnoid cyst of the cerebellopontine angle associated with gliosis of the eighth cranial nerve.
  • The clinical syndrome produced by a cyst in the cerebellopontine angle (CPA) may closely mimic that of an acoustic neuroma, with sensorineural hearing loss, impaired corneal reflex, and cerebellar signs with increased intracranial pressure.
  • Gliosis of the eighth nerve is common but its association with CPA arachnoid cyst is very rare and not previously reported.
  • We report a patient with a CPA arachnoid cyst associated with gliosis of the eighth cranial nerve.
  • He presented with right peripheral facial palsy, and gliosis of the eighth nerve was diagnosed intraoperatively.
  • CPA arachnoid cysts should be included in the differential diagnosis of peripheral facial palsy and the eighth cranial nerve should be examined during the resection and fenestration of the arachnoid cyst.
  • [MeSH-major] Arachnoid Cysts / complications. Cerebellar Neoplasms / complications. Cerebellopontine Angle / pathology. Cranial Nerve Neoplasms / complications. Gliosis / complications. Vestibulocochlear Nerve / pathology

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  • (PMID = 17475499.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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81. Lassaletta L, Patrón M, Del Río L, Alfonso C, Roda JM, Rey JA, Gavilan J: Cyclin D1 expression and histopathologic features in vestibular schwannomas. Otol Neurotol; 2007 Oct;28(7):939-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cyclin D1 expression and histopathologic features in vestibular schwannomas.
  • OBJECTIVE: To evaluate cyclin D1 expression in vestibular schwannoma and its relationship with histologic, clinical, and radiologic features.
  • PATIENTS: Twenty-one patients with histologically confirmed vestibular schwannoma.
  • Cyclin D1 expression was more frequent in right-sided tumors (p = 0.02) and in tumors with nuclear degenerative changes (p < 0.0001).
  • CONCLUSION: Cyclin D1 expression, present in nearly half of the cases, may play a role in the development of these tumors.
  • Further studies are needed to fully understand the contributions of histopathologic and immunohistochemical factors to vestibular schwannoma biological activity.
  • [MeSH-major] Cranial Nerve Neoplasms / genetics. Cranial Nerve Neoplasms / pathology. Gene Expression Regulation, Neoplastic / genetics. Genes, bcl-1 / genetics. Neuroma, Acoustic / genetics. Neuroma, Acoustic / pathology. Vestibulocochlear Nerve Diseases / genetics. Vestibulocochlear Nerve Diseases / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Audiometry. Deafness / etiology. Female. Hearing Loss / etiology. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Middle Aged. Paraffin Embedding. Vestibular Nuclei / pathology

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  • (PMID = 17704717.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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82. Otto SR, Shannon RV, Wilkinson EP, Hitselberger WE, McCreery DB, Moore JK, Brackmann DE: Audiologic outcomes with the penetrating electrode auditory brainstem implant. Otol Neurotol; 2008 Dec;29(8):1147-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PATIENTS AND PROTOCOL: In a prospective clinical trial, 10 individuals, all with neurofibromatosis type 2, received a PABI after vestibular schwannoma removal via a translabyrinthine approach.
  • [MeSH-major] Auditory Brain Stem Implants. Deafness / surgery. Hearing Aids. Hearing Tests. Neurofibromatosis 2 / complications. Prostheses and Implants
  • [MeSH-minor] Adult. Cochlear Nerve / physiopathology. Electric Stimulation. Electrodes. Equipment Design. Female. Humans. Male. Middle Aged. Pitch Perception. Treatment Outcome. Young Adult

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  • (PMID = 18931643.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Grant] United States / NIDCD NIH HHS / DC / N01-DC-1-2105; United States / NIDCD NIH HHS / DC / N01-DC-4-0005
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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83. Banerjee R, Moriarty JP, Foote RL, Pollock BE: Comparison of the surgical and follow-up costs associated with microsurgical resection and stereotactic radiosurgery for vestibular schwannoma. J Neurosurg; 2008 Jun;108(6):1220-4
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  • [Title] Comparison of the surgical and follow-up costs associated with microsurgical resection and stereotactic radiosurgery for vestibular schwannoma.
  • OBJECT: The best approach to the management of vestibular schwannoma (VS) remains controversial.
  • From a societal perspective, radiosurgery is less expensive than microsurgical resection provided that the rate of tumor progression after radiosurgery remains low with long-term follow-up.
  • [MeSH-major] Health Care Costs. Microsurgery / economics. Neuroma, Acoustic / therapy. Radiosurgery / economics

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  • (PMID = 18518731.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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84. Maiuri F, Cappabianca P, Iaconetta G, Esposito F, Messina A: Simultaneous presentation of meningiomas with other intracranial tumours. Br J Neurosurg; 2005 Aug;19(4):368-75
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Simultaneous presentation of meningiomas with other intracranial tumours.
  • Fifteen patients with simultaneous presentation of meningiomas with other intracranial tumours are reviewed.
  • The associated tumours included a brain metastasis in six cases, glioma in three, pituitary adenoma in two, craniopharyngioma in one,acoustic schwannoma in two and brain lymphoma in one.
  • The literature relating to meningiomas associated with other intracranial tumours is reviewed and the possible pathogenetic correlations are discussed.
  • The surgical indication and management of meningiomas may be significantly influenced by the presence of another different intracranial tumour.
  • [MeSH-major] Brain Neoplasms / diagnosis. Meningioma / diagnosis. Neoplasms, Multiple Primary / diagnosis
  • [MeSH-minor] Adult. Craniopharyngioma / diagnosis. Female. Glioma / diagnosis. Humans. Lymphoma, Large B-Cell, Diffuse / diagnosis. Magnetic Resonance Imaging. Male. Middle Aged. Neuroma, Acoustic / diagnosis. Pituitary Neoplasms / diagnosis. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 16455550.001).
  • [ISSN] 0268-8697
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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85. Doherty JK, Friedman RA: Controversies in building a management algorithm for vestibular schwannomas. Curr Opin Otolaryngol Head Neck Surg; 2006 Oct;14(5):305-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Controversies in building a management algorithm for vestibular schwannomas.
  • PURPOSE OF REVIEW: The present review examines the various mainstream treatment options, benefits and risks, and controversies involved in developing a management algorithm for treatment of vestibular schwannoma.
  • RECENT FINDINGS: Advances in microsurgery and radiosurgery have made tremendous contributions to management of vestibular schwannoma; however, considerable controversy still exists.
  • The auditory and facial nerve functional outcomes have improved with use of intraoperative monitoring for vestibular schwannoma removal and with lower radiosurgery doses; however, risks to the facial and auditory nerves still exist.
  • Observing vestibular schwannomas for growth with serial magnetic resonance imaging is an increasingly popular option for small vestibular schwannomas that allows patients to enjoy hearing and facial function.
  • SUMMARY: The risks and benefits of each treatment option must be weighed for each patient, and management decisions regarding vestibular schwannomas should be individualized for each patient depending on tumor anatomy, patient preferences, and symptoms.
  • [MeSH-major] Algorithms. Ear, Inner / surgery. Neuroma, Acoustic / therapy
  • [MeSH-minor] Cochlear Nerve / physiology. Facial Nerve / physiology. Hearing Loss / prevention & control. Humans. Magnetic Resonance Imaging. Microsurgery. Neurofibromatosis 2 / surgery. Neurofibromatosis 2 / therapy. Radiosurgery. Treatment Outcome

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  • [CommentIn] Curr Opin Otolaryngol Head Neck Surg. 2006 Oct;14(5):297-8 [16974140.001]
  • (PMID = 16974142.001).
  • [ISSN] 1068-9508
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 63
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86. Izci Y, Secer HI, Gönül E, Ongürü O: Simultaneously occurring vestibular schwannoma and meningioma in the cerebellopontine angle: case report and literature review. Clin Neuropathol; 2007 Sep-Oct;26(5):219-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Simultaneously occurring vestibular schwannoma and meningioma in the cerebellopontine angle: case report and literature review.
  • Simultaneously occurring multiple primary brain tumors of different histological types are rare, and the coexistence of schwannoma and meningioma in the same cerebellopontine angle (CPA) without neurofibromatosis is extremely rare.
  • Magnetic resonance imaging demonstrated two different tumors in the left CPA.
  • These tumors were not in continuity.
  • The tumors were totally removed through the left suboccipital approach.
  • Histopathological examination revealed that the large tumor was a vestibular schwannoma and the smaller was a meningioma.
  • The simultaneous occurrence of vestibular schwannoma and meningioma in the CPA appears coincidental.
  • This association must be kept in mind if two different tumors are detected radiologically in the same CPA.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellopontine Angle / pathology. Meningeal Neoplasms / pathology. Meningioma / pathology. Neoplasms, Multiple Primary / pathology. Neuroma, Acoustic / pathology

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  • (PMID = 17907598.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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87. Kakigi A, Nakatani H, Takeda T: Electrocochleographic and pure-tone audiometric findings in contralateral ear of unilateral acoustic neurinoma. ORL J Otorhinolaryngol Relat Spec; 2010;71 Suppl 1:78-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Electrocochleographic and pure-tone audiometric findings in contralateral ear of unilateral acoustic neurinoma.
  • OBJECTIVE: Auditory disorders of the contralateral ear in patients with unilateral acoustic neurinoma have previously been reported using the auditory brainstem response.
  • From our survey of the literature, there is no reported result about electrocochleography (ECoG) in the contralateral ear of acoustic neurinoma cases.
  • In the present study, we reported ECoG and pure-tone audiometric results of the contralateral ears in cases of unilateral acoustic neurinoma and the relationship between ECoG findings and tumor size was discussed.
  • METHODS: ECoG and pure-tone audiometry were performed for the contralateral ears in 27 cases of unilateral acoustic neurinoma, and the relationships between tumor size and contralateral ECoG findings and between pure-tone threshold and ECoG findings were investigated.
  • The tumor size was assessed by magnetic resonance imaging.
  • Incidences of abnormal -SP/AP ratio were 30.0% in large tumors (n = 10), 33.3% in mid-size tumors (n = 6) and 18.2% in small tumors (n = 11).
  • There was no correlation between the incidences of abnormal -SP/AP ratio and tumor size.
  • CONCLUSION: These results suggest that any size of acoustic neurinoma may affect contralateral electrocochleographic findings.
  • [MeSH-major] Audiometry, Evoked Response / methods. Audiometry, Pure-Tone. Neuroma, Acoustic / physiopathology

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  • (PMID = 20185954.001).
  • [ISSN] 1423-0275
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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88. Rosenvinge L, Johansen EC: [Schwannoma of the facial nerve--a rare disease, the choice of diagnostic imaging is very important]. Ugeskr Laeger; 2005 Apr 4;167(14):1530-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Schwannoma of the facial nerve--a rare disease, the choice of diagnostic imaging is very important].
  • [MeSH-major] Cranial Nerve Neoplasms / diagnosis. Facial Nerve Diseases / diagnosis. Neurilemmoma / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Neuroma, Acoustic / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 15887751.001).
  • [ISSN] 0041-5782
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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89. Liu D, Xu D, Zhang Z, Zhang Y, Zheng L: Long-term outcomes after Gamma Knife surgery for vestibular schwannomas: a 10-year experience. J Neurosurg; 2006 Dec;105 Suppl:149-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term outcomes after Gamma Knife surgery for vestibular schwannomas: a 10-year experience.
  • OBJECT: The authors sought to assess the results of Gamma Knife surgery (GKS) in patients with vestibular schwannomas (VSs).
  • Nineteen patients had undergone resection of their vs. Facial nerve function was normal in 63 patients (85.1%) before GKS, and 63.5% of them had useful hearing.
  • The mean volume of the tumor at GKS was 10.79 +/- 5.52 ml (range 0.11-27.8 ml).
  • At a median follow-up period of 68.3 months (range 30-122 months), tumor shrinkage was observed in 60 patients (81.1%), and the tumor size was stable in 11 (14.8%).
  • CONCLUSIONS: Gamma Knife surgery prevents tumor growth; it achieves excellent neurological function preservation and produces few treatment-related complications.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Neurilemmoma / surgery. Radiosurgery. Vestibular Nerve. Vestibulocochlear Nerve Diseases / surgery
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Survival Analysis. Time Factors. Treatment Outcome. Tumor Burden. Young Adult

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  • (PMID = 18503349.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Noudel R, Gomis P, Duntze J, Marnet D, Bazin A, Roche PH: Hearing preservation and facial nerve function after microsurgery for intracanalicular vestibular schwannomas: comparison of middle fossa and retrosigmoid approaches. Acta Neurochir (Wien); 2009 Aug;151(8):935-44; discussion 944-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hearing preservation and facial nerve function after microsurgery for intracanalicular vestibular schwannomas: comparison of middle fossa and retrosigmoid approaches.
  • PURPOSE: Therapeutic options for vestibular schwannomas (VS) include microsurgery, stereotactic radiosurgery and conservative management.
  • Early treatment of intracanalicular vestibular schwannomas (IVS) may be advisable because their spontaneous course will show hearing loss in most cases.
  • Advanced microsurgical techniques and continuous intraoperative monitoring of cranial nerves may allow hearing preservation (HP) without facial nerve damage.
  • There was a trend to show that the MF approach offered a better quality of postoperative hearing (not statistically significant), whereas the RS approach offered a better facial nerve preservation and fewer complications (not statistically significant).
  • CONCLUSIONS: We believe that the timing of treatment in the course of the disease and selection between radiosurgical versus microsurgical procedure are key issues in the management of Ivs. Preservation of hearing and good facial nerve function in surgery for VS is a reasonable goal for many patients with intracanalicular tumors and serviceable hearing.
  • [MeSH-major] Craniotomy / methods. Microsurgery / methods. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Neurosurgical Procedures / methods. Postoperative Complications / prevention & control
  • [MeSH-minor] Cranial Fossa, Middle / anatomy & histology. Cranial Fossa, Middle / surgery. Cranial Fossa, Posterior / anatomy & histology. Cranial Fossa, Posterior / surgery. Facial Nerve / anatomy & histology. Facial Nerve / surgery. Facial Nerve Injuries / etiology. Facial Nerve Injuries / physiopathology. Facial Nerve Injuries / prevention & control. Hearing Loss, Sensorineural / etiology. Hearing Loss, Sensorineural / physiopathology. Hearing Loss, Sensorineural / prevention & control. Humans. Occipital Bone / anatomy & histology. Occipital Bone / surgery. Petrous Bone / anatomy & histology. Petrous Bone / surgery. Vestibulocochlear Nerve / anatomy & histology. Vestibulocochlear Nerve / pathology. Vestibulocochlear Nerve / surgery


91. Evans DG, Moran A, King A, Saeed S, Gurusinghe N, Ramsden R: Incidence of vestibular schwannoma and neurofibromatosis 2 in the North West of England over a 10-year period: higher incidence than previously thought. Otol Neurotol; 2005 Jan;26(1):93-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Incidence of vestibular schwannoma and neurofibromatosis 2 in the North West of England over a 10-year period: higher incidence than previously thought.
  • OBJECTIVE: To determine the incidence of vestibular schwannoma (VS) in sporadic, neurofibromatosis type 2 (NF2) germ-line and mosaic form in a 10-year period.
  • This represented an incidence of 10.4 per million per year for sporadic VS and 11.8 per million per year including NF2-related tumors.
  • More VS than previously thought are due to NF2, which may be because of recognition of mosaic forms of the disease.
  • [MeSH-major] Neurofibromatosis 2 / epidemiology. Neuroma, Acoustic / epidemiology

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  • (PMID = 15699726.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. Takahashi H, Nakao M, Kaga K: Accessing ampli-tonotopic organization of rat auditory cortex by microstimulation of cochlear nucleus. IEEE Trans Biomed Eng; 2005 Jul;52(7):1333-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Auditory brainstem implants (ABI) that electrically stimulate the surface of cochlear nucleus have been clinically used for the rehabilitation of deaf patients with bilateral vestibular schwannomas.
  • Our experimental results demonstrated that microstimulation of both the dorsal and ventral cochlear nucleus (DCN and VCN) could access the cortical ampli-tonotopic organization as acoustic stimuli did.
  • [MeSH-major] Action Potentials / physiology. Auditory Cortex / physiology. Auditory Perception / physiology. Cochlear Nucleus / physiology. Deep Brain Stimulation / methods. Evoked Potentials, Auditory / physiology. Nerve Net / physiology
  • [MeSH-minor] Animals. Brain Mapping / methods. Electrodes, Implanted. Feasibility Studies. Microelectrodes. Models, Animal. Rats. Rats, Wistar

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  • (PMID = 16041997.001).
  • [ISSN] 0018-9294
  • [Journal-full-title] IEEE transactions on bio-medical engineering
  • [ISO-abbreviation] IEEE Trans Biomed Eng
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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93. Penido Nde O, Tangerina RP, Kosugi EM, Abreu CE, Vasco MB: Vestibular Schwannoma: spontaneous tumor involution. Braz J Otorhinolaryngol; 2007 Nov-Dec;73(6):867-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vestibular Schwannoma: spontaneous tumor involution.
  • The natural history of Vestibular Schwannomas (VS) is yet not totally known, but most of them have the tendency to slow growth, sometimes without any kind of symptoms during the individuals entire time.
  • Considering tumors that grow, about 70% have grown less than 2mm an year.
  • Advanced radiological diagnosis, especially magnetic resonance imaging with gadolinium helps us diagnose small and less symptomatic tumors.
  • Treatment of choice still is complete tumor resection.
  • Surgical approaches have improved considerably and have helped preserve facial nerve function and hearing.
  • Considering VSs natural history, there is a possibility for conservative treatment for these tumors, because their growth in the first year after diagnosis predicts tumor growth behavior in the next years.
  • Surgery should be done in cases of tumor growth, patients desire or symptoms worsening.
  • Moreover, in terms of postoperative sequelae, there is no difference between patients who underwent surgery immediately after diagnosis and those who underwent initial conservative treatment for these tumors.
  • [MeSH-major] Neoplasm Regression, Spontaneous / pathology. Neuroma, Acoustic / pathology

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  • (PMID = 18278239.001).
  • [ISSN] 1808-8694
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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94. Lee HK, Kim IS, Lee WS: New method of identifying the internal auditory canal as seen from the middle cranial fossa approach. Ann Otol Rhinol Laryngol; 2006 Jun;115(6):457-60
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  • OBJECTIVES: The middle cranial fossa approach allows one to remove acoustic tumors and preserve the facial nerve and hearing.

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  • (PMID = 16805378.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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95. Huang X, Zhang J, Yang H, Yu T: Use of intraoperative ultrasonography to monitor surgery for large acoustic neuromas: a pilot study. J Med Ultrason (2001); 2010 Jan;37(1):15-9
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  • [Title] Use of intraoperative ultrasonography to monitor surgery for large acoustic neuromas: a pilot study.
  • PURPOSE: Operations for large acoustic neuromas were difficult.
  • METHODS: Fifteen patients with large acoustic neuromas underwent surgical interventions.
  • RESULTS: All tumors could be identified in ultrasonic images.
  • A larger tumor volume was seen in the IOUS group but without statistical significance (29.05 ± 15.47 vs. 21.82 ± 14.78 cm(3), P = 0.3718).
  • The use of IOUS did not prolong the operation time (404.29 ± 111.18 vs. 420.00 ± 114.24 min, P = 0.7921) and did not increase the rate of intracranial infections (28.57 vs. 25.00%, P = 1.000).
  • The residual tumor detected with IOUS immediately after the operation was consistent with the data from postoperative CT/MRI scans in all cases.
  • CONCLUSION: IOUS can be used to monitor surgery in real time as a technique to assist microsurgical procedures for large acoustic neuromas with trouble.

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  • (PMID = 27277605.001).
  • [ISSN] 1346-4523
  • [Journal-full-title] Journal of medical ultrasonics (2001)
  • [ISO-abbreviation] J Med Ultrason (2001)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Acoustic neuroma / Intraoperative ultrasonography / Microsurgery
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96. Benech F, Perez R, Fontanella MM, Morra B, Albera R, Ducati A: Cystic versus solid vestibular schwannomas: a series of 80 grade III-IV patients. Neurosurg Rev; 2005 Jul;28(3):209-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cystic versus solid vestibular schwannomas: a series of 80 grade III-IV patients.
  • Cystic acoustic neuromas are less frequent than solid ones and present different clinical and radiological features.
  • Cystic schwannomas are larger, show a shorter clinical history and a different risk of postoperative complications.
  • This study was designed to compare surgical results and complications of solid and cystic vestibular schwannomas of matching size operated upon via either a retrosygmoid or a translabyrinthine approach.
  • The study included 80 patients presenting with grade III and IV acoustic vestibular schwannomas referred to the Neurosurgical and ENT team in the Department of Neuroscience of Torino, Italy.
  • In cystic tumors, rapid clinical worsening is common, due to sudden expansion of cystic elements.
  • Tighter adherences are found between cystic tumours and nervous elements (particularly brainstem and possibly facial nerve), once compared to solid ones.
  • Careful technique, possibly sharp dissection, to divide the tumour adherences from the nervous tissue must be employed, in order to avoid lesions on brainstem veins and traction on a thin facial nerve.
  • [MeSH-minor] Adult. Aged. Connective Tissue / pathology. Connective Tissue / surgery. Female. Humans. Immunohistochemistry. Male. Microsurgery. Middle Aged. Neoplasm Recurrence, Local. Pituitary Hormones / deficiency

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  • [ISSN] 0344-5607
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
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97. Merkus P, Taibah A, Sequino G, Sanna M: Less than 1% cerebrospinal fluid leakage in 1,803 translabyrinthine vestibular schwannoma surgery cases. Otol Neurotol; 2010 Feb;31(2):276-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Less than 1% cerebrospinal fluid leakage in 1,803 translabyrinthine vestibular schwannoma surgery cases.
  • OBJECTIVE: To determine the incidence rate of cerebrospinal fluid (CSF) leak after translabyrinthine vestibular schwannoma surgery since the alteration of the surgical procedure.
  • PATIENTS: A series of 1,803 patients who underwent translabyrinthine vestibular schwannoma surgery between 1993 and 2009.
  • INTERVENTION: Translabyrinthine and extended translabyrinthine vestibular schwannoma surgery.
  • CONCLUSION: The methods used in translabyrinthine vestibular schwannoma surgery in our center can reduce CSF leakage to an absolute minimum.
  • Compared with all large series, this could be a new era of translabyrinthine vestibular schwannoma surgery.
  • [MeSH-major] Ear, Inner / surgery. Neuroma, Acoustic / cerebrospinal fluid. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods. Postoperative Complications / prevention & control

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  • (PMID = 20042905.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 31
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98. Lenarz M, Lim HH, Patrick JF, Anderson DJ, Lenarz T: Electrophysiological validation of a human prototype auditory midbrain implant in a guinea pig model. J Assoc Res Otolaryngol; 2006 Dec;7(4):383-98
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This includes neurofibromatosis type II (NF2) patients who, due to development and/or removal of vestibular schwannomas, usually experience complete damage of their auditory nerves.

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  • (PMID = 17075701.001).
  • [ISSN] 1525-3961
  • [Journal-full-title] Journal of the Association for Research in Otolaryngology : JARO
  • [ISO-abbreviation] J. Assoc. Res. Otolaryngol.
  • [Language] ENG
  • [Grant] United States / NIBIB NIH HHS / EB / P41 EB002030; United States / NIDCD NIH HHS / DC / P30 DC005188; United States / NIBIB NIH HHS / EB / P41 EB2030; United States / NIDCD NIH HHS / DC / F31 DC007009; United States / NIDCD NIH HHS / DC / T32 DC00011; United States / NIDCD NIH HHS / DC / P30 DC05188; United States / NIDCD NIH HHS / DC / T32 DC000011
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Validation Studies
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2504634
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99. Roser F, Tatagiba MS: The first 50s: can we achieve acceptable results in vestibular schwannoma surgery from the beginning? Acta Neurochir (Wien); 2010 Aug;152(8):1359-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The first 50s: can we achieve acceptable results in vestibular schwannoma surgery from the beginning?
  • OBJECTIVE: Vestibular schwannoma surgery requires a profound knowledge of anatomy and long-standing experience of surgical skull base techniques, as patients nowadays requests high-quality results from any surgeon.
  • METHODS: The first 50 vestibular schwannomas of the first author were retrospectively evaluated concerning morbidity and mortality with an emphasis on functional cranial nerve preservation.
  • RESULTS: Fifty vestibular schwannomas were consecutively operated from July 2007 to January 2010.
  • The overall facial nerve preservation rate was 96%.
  • Hearing preservation in T1/2 schwannomas was achieved in 66%, in patients with T3 tumours in 56%, and in large T4 tumours in 25%.
  • [MeSH-major] Education, Medical, Graduate / standards. Neuroma, Acoustic / surgery. Neurosurgical Procedures / adverse effects. Neurosurgical Procedures / mortality. Postoperative Complications / epidemiology. Postoperative Complications / prevention & control
  • [MeSH-minor] Adult. Aged. Female. Humans. Iatrogenic Disease / prevention & control. Male. Middle Aged. Outcome Assessment (Health Care) / methods. Retrospective Studies. Treatment Outcome

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  • (PMID = 20440629.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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100. Liu BY, Tian YJ, Liu W, Liu SL, Qiao H, Zhang JT, Jia GJ: Intraoperative facial motor evoked potentials monitoring with transcranial electrical stimulation for preservation of facial nerve function in patients with large acoustic neuroma. Chin Med J (Engl); 2007 Feb 20;120(4):323-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraoperative facial motor evoked potentials monitoring with transcranial electrical stimulation for preservation of facial nerve function in patients with large acoustic neuroma.
  • The aim of this study was to investigate the effect of intraoperative facial motor evoked potentials monitoring with transcranial electrical stimulation on preservation of facial nerve function.
  • METHOD: From January to November 2005, 19 patients with large acoustic neuroma were treated using intraoperative facial motor evoked potentials monitoring with transcranial electrical stimulation (TCEMEP) for preservation of facial nerve function.
  • The relationship between the decrease of MEP amplitude after tumor removal and the postoperative function of the facial nerve was analyzed.
  • CONCLUSIONS: Intraoperative TCEMEP can be used to predict postoperative function of the facial nerve.
  • [MeSH-major] Electric Stimulation Therapy. Evoked Potentials, Motor. Facial Nerve / physiopathology. Monitoring, Intraoperative. Neuroma, Acoustic / physiopathology






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