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1. Patrinou A, Malindretos P, Koutroubas G, Anagnostou N, Argiraki E, Syrganis C: A rare retroperitoneal schwannoma in a patient with neurofibromatosis Type 2. NDT Plus; 2010 Jun;3(3):288-290

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare retroperitoneal schwannoma in a patient with neurofibromatosis Type 2.
  • Neurofibromatosis Type 2 (NF2) is a dominantly inherited tumour-prone disorder, characterized by the development of multiple schwannomas, meningiomas and ependymomas.
  • Vestibular schwannoma (VS) is the hallmark of NF2.
  • Retroperitoneal schwannomas are expected to occur in only 3% of cases.
  • We present the case of a large retroperitoneal schwannoma in a patient with NF2.
  • Brain, orbits, cervical, thoracic and lumbar MRI revealed bilateral VS, multiple meningiomas as well as multiple schwannomas and ependymomas in the cervical, thoracic and lumbar spine.
  • The retroperitoneal mass represents a schwannoma probably derived from an intercostal nerve.

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  • (PMID = 28657039.001).
  • [ISSN] 1753-0784
  • [Journal-full-title] NDT plus
  • [ISO-abbreviation] NDT Plus
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; meningioma / neurofibromatosis Type 2 / retroperitoneal / schwannoma
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2. Muñoz Herrera A, Coscarón Blanco E, Beltrán Mateos LD, Paniagua Escudero J, Morales Ramos F: [Auditory-evoked brainstem response in a schwannoma of the VIIIth cranial nerve: an anatomophysiological and functional correlation. Our experience]. Acta Otorrinolaringol Esp; 2005 Apr;56(4):147-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Auditory-evoked brainstem response in a schwannoma of the VIIIth cranial nerve: an anatomophysiological and functional correlation. Our experience].
  • [Transliterated title] Respuesta evocada auditiva de tronco en el schwannoma del VIII par: correlación anatomofisiológica y funcional. Nuestra experiencia.
  • INTRODUCTION: Schwannomas are tumors charasteristically originated from the nerve sheath.
  • They expande eccentrically from the nerve promoting a disturbance in the neural function either due to vascular compresion or to the effect of the tumor itself on the nerve, disturbance that can be evidenced with the Auditory-evoked Brainstem Response (ABR), fact that constituted the base for their diagnosis in the past.
  • The new radiological techniques developed over the last decades have made possible an earlier diagnosis, and therefore changed their prognosis in terms of nerve function.
  • OBJECTIVE: To describe the most frequent ABR patterns in those patients suffering from acoustic schwannoma related to the size of the tumour and the remanent audition thresholds, and to determine the value of this test in our practice.
  • RESULTS AND CONCLUSIONS: ABR has a good sensibility for detection of acoustic schwannoma.
  • [MeSH-major] Cranial Nerve Neoplasms / physiopathology. Evoked Potentials, Auditory, Brain Stem. Neurilemmoma / physiopathology

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  • (PMID = 15871289.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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3. Rasalingam K, Abdullah JM, Idris Z, Pal HK, Wahab N, Omar E, Mar SW: A rare case of paediatric pontine glioblastoma presenting as a cerebellopontine angle otogenic abscess. Malays J Med Sci; 2008 Jan;15(1):44-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Contrast enhanced CT scan of the brain showed a lesion in the right cerebellopontine angle with mild enhancement mimicking early abscess formation.
  • Intraoperatively, about 90% of the tumour was removed and the appearance of the tumour resembled that of an acoustic schwannoma but histopathology confirmed the diagnosis of a glioblastoma multiforme (GBM).

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  • (PMID = 22589615.001).
  • [ISSN] 1394-195X
  • [Journal-full-title] The Malaysian journal of medical sciences : MJMS
  • [ISO-abbreviation] Malays J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Malaysia
  • [Other-IDs] NLM/ PMC3341898
  • [Keywords] NOTNLM ; Maxillary molar abscess / cavernous sinus thrombosis / superior ophthalmic vein thrombosis
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4. Gil Z, Fliss DM: Quality of life in patients with skull base tumors: current status and future challenges. Skull Base; 2010 Jan;20(1):11-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Quality of life in patients with skull base tumors: current status and future challenges.
  • In selection of the right treatment for a specific patient, the surgeon should consider not only the best approach to remove a tumor but also the impact of treatment on the quality of life (QOL) of the patient.
  • Procedures involving extirpation of skull base tumors may be associated with high morbidity.
  • The overall QOL in the majority of patients after skull base tumor resection can be classified as "good," with significant improvement taking place within 12 months following surgery.
  • Patients with carcinomas, acoustic schwannoma, or Cushing's disease suffer from more significant deterioration in their QOL after any intervention.
  • Data retrieved from disease-specific questionnaires revealed that the financial and emotional domains have the worse impact on patients QOL.
  • For adequate assessment, validated disease-specific instruments addressing multiple domains of QOL should be utilized.

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  • (PMID = 20592852.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2853066
  • [Keywords] NOTNLM ; Quality of life / cancer / cranial base / craniofacial / neurosurgery
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5. Gelal F, Rezanko T, Uyaroglu MA, Tunakan M, Bezircioglu H: Islets of meningioma in an acoustic schwannoma in a patient with neurofibromatosis-2: pathology and magnetic resonance imaging findings. Acta Radiol; 2005 Aug;46(5):519-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Islets of meningioma in an acoustic schwannoma in a patient with neurofibromatosis-2: pathology and magnetic resonance imaging findings.
  • Mixed tumors of the cerebellopontine angle, composed of meningioma and schwannoma components, are extremely rare; so far, only 12 cases have been reported in the literature.
  • We present a mixed tumor of schwannoma and meningioma in a patient with neurofibromatosis-2 and discuss the pathology and magnetic resonance imaging (MRI) findings in relation to the literature.
  • Review of the literature shows that a typical MRI pattern has not been established for mixed tumors and it seems unlikely that a meningioma component can be differentiated within a schwannoma preoperatively.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningioma / pathology. Neoplasms, Complex and Mixed / pathology. Neurofibromatosis 2 / pathology. Neuroma, Acoustic / pathology

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  • (PMID = 16224929.001).
  • [ISSN] 0284-1851
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
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6. Arthurs BJ, Lamoreaux WT, Giddings NA, Fairbanks RK, Mackay AR, Demakas JJ, Cooke BS, Lee CM: Gamma Knife radiosurgery for vestibular schwannoma: case report and review of the literature. World J Surg Oncol; 2009;7:100
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gamma Knife radiosurgery for vestibular schwannoma: case report and review of the literature.
  • Vestibular schwannomas, also called acoustic neuromas, are benign tumors of the vestibulocochlear nerve.
  • Unfortunately, definitive guidelines for treating vestibular schwannomas are lacking, because of insufficient evidence comparing the outcomes of therapeutic modalities.We present a contemporary case report, describing the finding of a vestibular schwannoma in a patient who presented with dizziness and a "clicking" sensation in the ear, but no hearing deficit.
  • Audible clicking is a symptom that, to our knowledge, has not been associated with vestibular schwannoma in the literature.
  • This case highlights an atypical presentation of vestibular schwannoma, associated with audible "clicks" and normal hearing.
  • We also provide a concise review of the available literature on modern vestibular schwannoma treatment, which may be useful in guiding treatment decisions.
  • [MeSH-major] Neurilemmoma / surgery. Neuroma, Acoustic / surgery. Radiosurgery. Vestibular Nerve / surgery

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  • (PMID = 20021676.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2803477
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7. Alfonso C, Lassaletta L, Sarriá J, Gavilán J: [Quality of life following vestibular schwannoma surgery]. Acta Otorrinolaringol Esp; 2007 Feb;58(2):61-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Quality of life following vestibular schwannoma surgery].
  • [Transliterated title] Calidad de vida tras la cirugía del schwannoma vestibular.
  • OBJECTIVE: This study evaluates quality of life (QOL) in patients following surgery for vestibular schwannoma (VS) using the Glasgow Benefit Inventory (GBI), and a pain questionnaire.
  • No differences in postoperative QOL were found when comparing side, gender, age, tumor size, hearing preservation, or post-operative facial function.
  • Deterioration of postoperative QOL was less frequent in patients with vertigo and brain stem compression before surgery.
  • [MeSH-major] Neuroma, Acoustic / surgery. Quality of Life / psychology

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  • (PMID = 17371684.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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8. Choy NL, Johnson N, Treleaven J, Jull G, Panizza B, Brown-Rothwell D: Balance, mobility and gaze stability deficits remain following surgical removal of vestibular schwannoma (acoustic neuroma): an observational study. Aust J Physiother; 2006;52(3):211-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Balance, mobility and gaze stability deficits remain following surgical removal of vestibular schwannoma (acoustic neuroma): an observational study.
  • QUESTION: Are there residual deficits in balance, mobility, and gaze stability after surgical removal of vestibular schwannoma?
  • PARTICIPANTS: Twelve people with a mean age of 52 years who had undergone surgical removal of vestibular schwannoma at least three months previously and had not undergone vestibular rehabilitation.
  • CONCLUSION: A prospective study is required to evaluate vestibular rehabilitation to ameliorate dizziness and to improve balance, mobility, and gaze stability for this clinical group.
  • [MeSH-major] Mobility Limitation. Neuroma, Acoustic / complications. Neuroma, Acoustic / surgery. Ocular Motility Disorders / etiology. Postural Balance. Sensation Disorders / etiology


9. van Eck AT, Horstmann GA: Increased preservation of functional hearing after gamma knife surgery for vestibular schwannoma. J Neurosurg; 2005 Jan;102(s_supplement):204-206

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Increased preservation of functional hearing after gamma knife surgery for vestibular schwannoma.
  • OBJECT: Gamma knife surgery (GKS) for vestibular schwannoma is still associated with an additional hearing loss of approximately 30%.
  • The mean tumor volume was 2.28 cm<sup>3</sup>.
  • After a mean follow-up duration of 22 months, the magnetic resonance imaging-based tumor control rate was 87%.
  • One patient suffered transient facial nerve impairment.
  • CONCLUSIONS: Reducing the maximum dose to 20 Gy seems to be an effective treatment, which probably increases preservation of functional hearing without sacrificing the high tumor control rates achieved in radiosurgery.
  • Post-radiosurgery tumor swelling occurred in 25% of the cases and was not correlated with hearing deterioration.

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  • (PMID = 28306452.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; acoustic neurinoma / gamma knife surgery / hearing preservation / tumor swelling / vestibular schwannoma
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10. Chung WY, Liu KD, Shiau CY, Wu HM, Wang LW, Guo WY, Ming-Tak Ho D, Hung-Chi Pan D: Gamma knife surgery for vestibular schwannoma: 10-year experience of 195 cases. J Neurosurg; 2005 Jan;102(s_supplement):87-97

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gamma knife surgery for vestibular schwannoma: 10-year experience of 195 cases.
  • OBJECT: The authors conducted a study to determine the optimal radiation dose for vestibular schwannoma (VS) and to examine the histopathology in cases of treatment failure for better understanding of the effects of irradiation.
  • Seventy-two patients (37%) had undergone partial or total excision of their tumor prior to gamma knife surgery (GKS).
  • The mean tumor volume was 4.1 cm<sup>3</sup> (range 0.04-23.1 cm<sup>3</sup>).
  • Multiisocenter dose planning placed a prescription dose of 11 to 18.2 Gy on the 50 to 94% isodose located at the tumor margin.
  • At the latest MR imaging assessment decreased or stable tumor volume was demonstrated in 93.6% of the patients.
  • Uncontrolled tumor swelling was noted in five patients at 3.5, 17, 24, 33, and 62 months after GKS, respectively.
  • Histopathological examination of specimens in three cases (one at 62 months after GKS) revealed a long-lasting radiation effect on vessels inside the tumor.
  • A margin 12-Gy dose with homogeneous distribution is effective in preventing tumor progression, while posing no serious threat to normal cranial nerve function.

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  • (PMID = 28306447.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; gamma knife surgery / stereotaxy / vestibular schwannoma
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11. Chopra R, Kondziolka D, Niranjan A, Lunsford LD, Flickinger JC: Long-term follow-up of acoustic schwannoma radiosurgery with marginal tumor doses of 12 to 13 Gy. Int J Radiat Oncol Biol Phys; 2007 Jul 1;68(3):845-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term follow-up of acoustic schwannoma radiosurgery with marginal tumor doses of 12 to 13 Gy.
  • PURPOSE: To define long-term tumor control and clinical outcomes of radiosurgery with marginal tumor doses of 12 to 13 Gy for unilateral acoustic schwannoma.
  • METHODS AND MATERIALS: A total of 216 patients with previously untreated unilateral acoustic schwannoma underwent Gamma Knife radiosurgery between 1992 and 2000 with marginal tumor doses of 12 to 13 Gy (median, 13 Gy).
  • Three patients required tumor resection: 2 for tumor growth and 1 partial resection for an enlarging adjacent subarachnoid cyst.
  • For 25 of these patients with intracanalicular tumors, the respective rates for preserving the same Gardner-Robertson level, serviceable hearing, and testable hearing were 80%, 88%, and 96%.
  • Ten-year actuarial rates for preserving the same Gardner-Robertson hearing levels, serviceable hearing, any testable hearing, and unchanged facial and trigeminal nerve function were 44.0% +/- 11.7%, 44.5% +/- 10.5%, 85.3% +/- 6.2%, 100%, and 94.9% +/- 1.8%, respectively.
  • CONCLUSIONS: Acoustic schwannoma radiosurgery with 12 to 13 Gy provides high rates of long-term tumor control and cranial nerve preservation after long-term follow-up.
  • [MeSH-major] Cranial Nerve Diseases / epidemiology. Hearing Disorders / epidemiology. Neuroma, Acoustic / mortality. Neuroma, Acoustic / surgery. Radiation Injuries / mortality. Radiosurgery / mortality. Risk Assessment / methods

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  • (PMID = 17379451.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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12. Hasegawa T, Kida Y, Yoshimoto M, Koike J, Goto K: TABLEEvaluation of Tumor Expansion after Stereotactic Radiosurgery in Patients Harboring Vestibular Schwannomas. Neurosurgery; 2006 Jun 01;58(6):1119-1128

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] TABLEEvaluation of Tumor Expansion after Stereotactic Radiosurgery in Patients Harboring Vestibular Schwannomas.

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  • (PMID = 28173267.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Tlachacova D, Schmitt M, Novotny J Jr, Novotny J, Majali M, Liscak R: A comparison of the gamma knife model C and the Automatic Positioning System with Leksell model B. J Neurosurg; 2005 Jan;102(s_supplement):25-28
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  • Data were analyzed in patients in whom the following diagnoses had been made: vestibular schwannoma, pituitary adenoma, meningioma, solitary metastasis, and other benign and malignant solitary tumors.
  • CONCLUSIONS: With the C model there was a better conformity for most treated targets, such as vestibular schwannomas (p = 0.005) and meningiomas (p = 0.015).

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  • (PMID = 28306471.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; conformity index / extracranial exposure / staff exposure / stereotactic radiosurgery
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14. Wowra B, Muacevic A, Jess-Hempen A, Hempel JM, Müller-Schunk S, Tonn JC: Outpatient gamma knife surgery for vestibular schwannoma: definition of the therapeutic profile based on a 10-year experience. J Neurosurg; 2005 Jan;102(s_supplement):114-118
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  • [Title] Outpatient gamma knife surgery for vestibular schwannoma: definition of the therapeutic profile based on a 10-year experience.
  • OBJECT: The purpose of the study was to define the therapeutic profile of outpatient gamma knife surgery (GKS) for vestibular schwannoma (VS) by using sequential tumor volumetry to quantify changes following treatment.
  • The actuarial 6-year tumor control rate after a single GKS treatment was 95%.
  • Tumor swelling was observed in 43 patients (38.7%).
  • Recurrence was significantly associated with NF2 (p < 0.003) and the reduced dose (p < 0.03) delivered to these tumors.
  • The incidence of facial nerve neuropathy was mainly determined by surgery prior to GKS (p < 0.0001).
  • Facial nerve radiation toxicity was mild and transient.
  • No permanent facial nerve toxicity was observed.
  • The risk of hearing loss was correlated with age and transient tumor swelling (p < 0.05) but not with dose parameters or NF2.

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  • (PMID = 28306422.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; gamma knife surgery / tumor volumetry / vestibular schwannoma
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15. Myrseth E, Møller P, Wentzel-Larsen T, Goplen F, Lund-Johansen M: Untreated Vestibular Schwannoma: Vertigo is a Powerful Predictor for Health-Related Quality of Life. Neurosurgery; 2006 Jul 01;59(1):67-76

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  • [Title] Untreated Vestibular Schwannoma: Vertigo is a Powerful Predictor for Health-Related Quality of Life.

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  • (PMID = 28180608.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Piedra MP, Scheithauer BW, Driscoll CL, Link MJ: Primary Melanocytic Tumor of the Cerebellopontine Angle Mimicking a Vestibular Schwannoma. Neurosurgery; 2006 Jul 01;59(1):E206

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary Melanocytic Tumor of the Cerebellopontine Angle Mimicking a Vestibular Schwannoma.

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  • (PMID = 28180621.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Inoue HK: Low-dose radiosurgery for large vestibular schwannomas: long-term results of functional preservation. J Neurosurg; 2005 Jan;102(s_supplement):111-113

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Low-dose radiosurgery for large vestibular schwannomas: long-term results of functional preservation.
  • OBJECT: The author conducted a study to assess the long-term results obtained in patients who underwent GKS for large vestibular schwannomas (> cochlear nerve functions were evaluated.
  • METHODS: Twenty consecutive large tumors in 18 patients (including two cases of neurofibromatosus Type 2 [NF2]) were followed for more than 6 years.
  • There were eight tumors that were more than 4 cm in maximum diameter.
  • Microsurgery had already been performed prior to GKS in 11 patients (nine recurrent and two residual tumors).
  • Fourteen of 15 tumors were stable or decreased in size.
  • Facial nerve function was preserved in all patients and hearing preserved in four of five patients with cochlear nerve function prior to radiosurgery.
  • CONCLUSIONS: Gamma knife surgery seems to have a place in the low-dose treatment of selected large vestibular schwannoma in patients with a reasonable chance of retaining facial function and pretreatment hearing level.

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  • (PMID = 28306427.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; facial function / gamma knife surgery / outcome / vestibular schwannoma
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18. Horger M, Korn A, Ioanoviciu SD, Ritz R, Ernemann U: [Imaging findings in acoustic schwannoma]. Rofo; 2010 Apr;182(4):299-302
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  • [Title] [Imaging findings in acoustic schwannoma].
  • [Transliterated title] Akustikusschwannom: bildgebende Diagnostik.
  • [MeSH-major] Diffusion Magnetic Resonance Imaging. Image Enhancement. Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Neuroma, Acoustic / diagnosis. Tomography, X-Ray Computed
  • [MeSH-minor] Combined Modality Therapy. Contrast Media / administration & dosage. Humans. Microsurgery. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / pathology. Radiosurgery. Radiotherapy, Adjuvant

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  • (PMID = 20401830.001).
  • [ISSN] 1438-9010
  • [Journal-full-title] RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
  • [ISO-abbreviation] Rofo
  • [Language] ger
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
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19. Ottinger T, Lindberg R, Ekman S: Malignant acoustic schwannoma in a dog. J Vet Diagn Invest; 2009 Jan;21(1):129-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant acoustic schwannoma in a dog.
  • A malignant schwannoma of the right acoustic nerve of a dog is described.
  • The neoplasm was found during necropsy of a 12-year-old, spayed, female Labrador Retriever that experienced a sudden onset of severe pain in the neck and upon opening the mouth.
  • The tumor had infiltrative growth, and the spindle-shaped neoplastic cells were arranged in sheets and concentric whorls.
  • [MeSH-major] Dog Diseases / pathology. Neuroma, Acoustic / veterinary
  • [MeSH-minor] Animals. Cochlear Nerve / pathology. Dogs. Female

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  • (PMID = 19139514.001).
  • [ISSN] 1040-6387
  • [Journal-full-title] Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • [ISO-abbreviation] J. Vet. Diagn. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Schlieter M, Zoubaa S, Kress B, Unterberg A, Jacobi C, Hähnel S: Hemorrhagic acoustic schwannoma: radiological and histopathological findings. J Neuroradiol; 2005 Jun;32(3):210-2
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  • [Title] Hemorrhagic acoustic schwannoma: radiological and histopathological findings.
  • A 49-year-old man on anticoagulation treatment with phenprocoumon presented with acute right sided 7th and 8th cranial nerve palsy, acute hearing loss, headache, vertigo, and vomiting.
  • CT and MRI revealed a cerebellopontine angle tumor 15mm in diameter and acute intratumoral hematoma.
  • A cellular schwannoma composed predominantly of Antoni A tissue with dilated thin-walled vessels, surrounded by old hemorrhage with hemosiderin-laden macrophages was found histologically.
  • [MeSH-major] Cerebral Hemorrhage / pathology. Cerebral Hemorrhage / radiography. Neuroma, Acoustic / pathology. Neuroma, Acoustic / radiography
  • [MeSH-minor] Facial Nerve Diseases / etiology. Humans. Male. Middle Aged. Vestibulocochlear Nerve Diseases / etiology

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  • (PMID = 16134303.001).
  • [ISSN] 0150-9861
  • [Journal-full-title] Journal of neuroradiology. Journal de neuroradiologie
  • [ISO-abbreviation] J Neuroradiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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21. Lunsford LD, Niranjan A, Flickinger JC, Maitz A, Kondziolka D: Radiosurgery of vestibular schwannomas: summary of experience in 829 cases. J Neurosurg; 2005 Jan;102(s_supplement):195-199

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiosurgery of vestibular schwannomas: summary of experience in 829 cases.
  • OBJECT: Management options for vestibular schwannomas (VSs) have greatly expanded since the introduction of stereotactic radiosurgery.
  • Optimal outcomes reflect long-term tumor control, preservation of cranial nerve function, and retention of quality of life.
  • The average tumor volume was 2.5 cm<sup>3</sup>.
  • The median margin dose to the tumor was 13 Gy (range 10-20 Gy).
  • Unchanged hearing preservation was possible in 50 to 77% of patients (up to 90% in those with intracanalicular tumors).
  • Trigeminal symptoms were detected in less than 3% of patients whose tumors reached the level of the trigeminal nerve.
  • Tumor control rates at 10 years were 97% (no additional treatment needed).
  • Gamma knife surgery provides a low risk, minimally invasive treatment option for patients with newly diagnosed or residual vs. Cranial nerve preservation and quality of life maintenance are possible in long-term follow up.

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  • (PMID = 28306432.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; gamma knife surgery / radiosurgery / vestibular schwannoma
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22. Chung SJ, Im JH, Lee JH, Cho AH, Kwon M, Lee MC: Isolated tongue tremor after gamma knife radiosurgery for acoustic schwannoma. Mov Disord; 2005 Jan;20(1):108-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Isolated tongue tremor after gamma knife radiosurgery for acoustic schwannoma.
  • We describe a patient who had an isolated tongue tremor with an audible click after gamma knife radiosurgery for acoustic schwannoma.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / adverse effects. Tongue Diseases / etiology. Tremor / etiology

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  • [Copyright] (c) 2004 Movement Disorder Society.
  • (PMID = 15390040.001).
  • [ISSN] 0885-3185
  • [Journal-full-title] Movement disorders : official journal of the Movement Disorder Society
  • [ISO-abbreviation] Mov. Disord.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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23. Sone M, Katayama N, Otake N, Sato E, Fujimoto Y, Ito M, Nakashima T: Characterizing the auditory changes in tumor metastasis to the bilateral internal auditory canals. J Clin Neurosci; 2007 May;14(5):470-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Characterizing the auditory changes in tumor metastasis to the bilateral internal auditory canals.
  • We report the changes in auditory function in a patient with tumor metastasis to the bilateral internal auditory canals (IAC).
  • However, distortion product otoacoustic emissions (DPOAE) were present at low frequencies, which suggests that the organ of Corti in its upper turn remained unaffected by tumor invasion.
  • Metastatic tumors in the bilateral IAC have been reported to mimic neurofibromatosis type 2, and radiological differentiation from acoustic schwannoma is difficult.
  • We characterize the hearing deterioration caused by metastasis of malignant tumors in the IAC.
  • [MeSH-major] Cranial Nerve Neoplasms / physiopathology. Evoked Potentials, Auditory, Brain Stem / physiology. Neoplasm Metastasis / physiopathology. Otoacoustic Emissions, Spontaneous / physiology
  • [MeSH-minor] Acoustic Stimulation / methods. Adenocarcinoma / pathology. Gastrointestinal Neoplasms / pathology. Humans. Male. Middle Aged

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  • (PMID = 17386369.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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24. Tashjian VS, Khanlou N, Vinters HV, Canalis RF, Becker DP: Hemangiopericytoma of the cerebellopontine angle: a case report and review of the literature. Surg Neurol; 2009 Sep;72(3):290-5
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  • BACKGROUND: Intracranial hemangiopericytoma represents a rare intracranial tumor that is typically difficult to distinguish from meningioma based on clinical presentation and radiographic findings.
  • These inherently aggressive neoplasms have been observed to occur in numerous intracranial compartments; however, isolated involvement of the CPA is essentially unreported.
  • The authors present a case of a young lady with presumed right acoustic schwannoma, which proved to be HPC on histopathology.
  • Magnetic resonance imaging demonstrated the presence of a homogeneously enhancing extraaxial lesion in the right CPA, radiographically suggestive of an acoustic schwannoma.
  • The lesion proved to be an intracranial HPC on histologic sections.
  • CONCLUSION: Given the fundamentally different treatment approach for HPCs over other more common CPA tumors, it is imperative that the treating surgeon consider this rare diagnosis when evaluating patients with lesions localized to this area.
  • Specifically, gross total resection, followed by adjuvant SRT, provides patients with the highest probability for disease-free survival, based on current evidence in the neurosurgical literature.
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Meningioma / diagnosis. Meningioma / surgery. Neoplasm Recurrence, Local / prevention & control. Positron-Emission Tomography. Radiotherapy, Adjuvant

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  • (PMID = 18786704.001).
  • [ISSN] 1879-3339
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 32
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25. Maiuri F, Cappabianca P, Iaconetta G, Esposito F, Messina A: Simultaneous presentation of meningiomas with other intracranial tumours. Br J Neurosurg; 2005 Aug;19(4):368-75
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Simultaneous presentation of meningiomas with other intracranial tumours.
  • Fifteen patients with simultaneous presentation of meningiomas with other intracranial tumours are reviewed.
  • The associated tumours included a brain metastasis in six cases, glioma in three, pituitary adenoma in two, craniopharyngioma in one,acoustic schwannoma in two and brain lymphoma in one.
  • The literature relating to meningiomas associated with other intracranial tumours is reviewed and the possible pathogenetic correlations are discussed.
  • The surgical indication and management of meningiomas may be significantly influenced by the presence of another different intracranial tumour.
  • [MeSH-major] Brain Neoplasms / diagnosis. Meningioma / diagnosis. Neoplasms, Multiple Primary / diagnosis
  • [MeSH-minor] Adult. Craniopharyngioma / diagnosis. Female. Glioma / diagnosis. Humans. Lymphoma, Large B-Cell, Diffuse / diagnosis. Magnetic Resonance Imaging. Male. Middle Aged. Neuroma, Acoustic / diagnosis. Pituitary Neoplasms / diagnosis. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 16455550.001).
  • [ISSN] 0268-8697
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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26. Ahmad SM, Garcia F, Sataloff RT: Cerebellopontine angle ganglionic hamartoma: case report. Ear Nose Throat J; 2010 Mar;89(3):128-31
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  • Magnetic resonance imaging revealed a mass on the intracanalicular segment of cranial nerve VIII on the left side, consistent with acoustic schwannoma.
  • She opted for observation of the tumor.
  • At this time, a working diagnosis of facial nerve neuroma was made.
  • Otolaryngologists should be familiar with this uncommon tumor and include it in the differential diagnosis of CPA lesions.
  • [MeSH-minor] Cochlear Nerve / physiopathology. Evoked Potentials, Auditory, Brain Stem. Facial Nerve Diseases / diagnosis. Facial Nerve Diseases / etiology. Female. Humans. Middle Aged

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  • (PMID = 20229478.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Morris BS, Nagar AM, Morani AC, Chaudhary RK, Garg PA, Chudgar PD, Raut AA: Blood-fluid levels in the brain. Br J Radiol; 2007 Jun;80(954):488-98
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Blood-fluid levels in the brain.
  • 17 cases reviewed prospectively over a period of 4 months highlight the varied appearance of blood-fluid levels in intracranial cystic lesions of different aetiologies; a finding which has not featured significantly in the medical literature.
  • Four types of intracranial cysts demonstrating blood-fluid levels have been categorised according to the nature of the pathology, i.e. primary neoplasms of the brain, metastatic deposits to the brain in cases of extraneural malignancies, lesions of vascular aetiology and intraparenchymal bleeds secondary to trauma.
  • The group of four primary intracranial neoplasms lists an oligodendroglioma, a recurrent tumour in a case of Von Hippel-Lindau syndrome, a Grade 3 astrocytoma and an acoustic schwannoma.
  • Four cases of metastatic deposits to the brain were each secondary to primary malignant neoplasms of the breast, liver, ovary and lung.
  • Intracranial cysts within tumours have been postulated to occur secondary to a breakdown of the blood-brain barrier (BBB) rather than as a result of tumoural degeneration, as was thought probable earlier.
  • [MeSH-major] Brain Diseases / physiopathology. Cysts / physiopathology
  • [MeSH-minor] Adolescent. Adult. Aged. Blood. Blood-Brain Barrier. Body Fluids. Brain / pathology. Brain / physiopathology. Brain / radiography. Brain Neoplasms / pathology. Brain Neoplasms / physiopathology. Brain Neoplasms / radiography. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Tomography, X-Ray Computed / methods

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  • (PMID = 17684079.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 20
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28. Matsui S, Sadaike T, Hamada C, Fukushima M: Creutzfeldt-Jakob disease and cadaveric dura mater grafts in Japan: an updated analysis of incubation time. Neuroepidemiology; 2005;24(1-2):22-5
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  • [Title] Creutzfeldt-Jakob disease and cadaveric dura mater grafts in Japan: an updated analysis of incubation time.
  • The incubation time for 76 patients with cadaveric dura mater-transmitted Creutzfeldt-Jakob disease reported in Japan by November 2001 was analyzed to clarify its distributional feature and the risk factors which affect the earlier onset of the disease.
  • Patients who were transplanted dura mater for facial spasms had a significantly shorter incubation time than those who received transplantation for other diseases including meningioma, aneurysm, or acoustic schwannoma.
  • These results suggest that some host factors may have an influence on the incubation time of the disease.

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  • (PMID = 15459505.001).
  • [ISSN] 0251-5350
  • [Journal-full-title] Neuroepidemiology
  • [ISO-abbreviation] Neuroepidemiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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29. Bartling SH, Peldschus K, Rodt T, Kral F, Matthies H, Kikinis R, Becker H: Registration and fusion of CT and MRI of the temporal bone. J Comput Assist Tomogr; 2005 May-Jun;29(3):305-10
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  • In the registered and fused datasets, important bony surgical landmarks (eg, facial nerve canal, inner ear) could be assessed in 3 dimensions relatively to tumor tissue (eg, acoustic schwannoma).
  • CONCLUSION: An accurate, reproducible registration and fusion method that improves tumor surgery and cochlea implantation planning with only minor changes to the clinical workflow was presented and described.

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  • (PMID = 15891495.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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30. Kambe A, Kamitani H, Watanabe T, Oka A, Inagaki H, Ishii T, Ueki K: A non-NF2 case of schwannomas of vestibular and trigeminal nerves with different genetic alterations of NF2 gene: case report. Surg Neurol; 2005 Jan;63(1):62-4; discussion 64-5
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  • [Title] A non-NF2 case of schwannomas of vestibular and trigeminal nerves with different genetic alterations of NF2 gene: case report.
  • BACKGROUND: We report a patient with 2 separate schwannomas, a vestibular schwannoma and a trigeminal schwannoma, that were attached to each other and appeared to be a single tumor on imaging studies.
  • CASE DESCRIPTION: The patient, without any family history of neurofibromatosis, presented with a progressive hearing loss and mild left facial nerve palsy.
  • Magnetic resonance imaging showed a snowman-like tumor in the left cerebellopontine angle.
  • Surgical exposure revealed that the tumor consisted of 2 "kissing" schwannomas, a trigeminal and vestibular schwannoma.
  • Molecular genetic analysis detected a 1-base pair deletion at exon 10 of the neurofibromatosis type 2 (NF2) gene in the trigeminal schwannoma, but not in the acoustic schwannoma.
  • However, loss of heterozygosity at chromosome 22q (D22S282 and D22S929) was detected in both tumors, losing the same allele.
  • CONCLUSION: Multiple schwannomas in non-NF2 patients are extremely rare, and possible causes include simple coincidence or germline genetic alteration of adjacent gene on chromosome 22q, similar to the cause recently suggested in familial schwannomatosis.
  • [MeSH-major] Genes, Neurofibromatosis 2. Neuroma, Acoustic / genetics. Trigeminal Nerve / pathology. Trigeminal Nerve Diseases / genetics. Vestibular Nerve / pathology
  • [MeSH-minor] Chromosomes, Human, Pair 22 / genetics. Craniotomy. DNA Mutational Analysis. Decompression, Surgical. Facial Nerve Diseases / etiology. Facial Nerve Diseases / pathology. Facial Nerve Diseases / physiopathology. Gene Deletion. Hearing Loss / etiology. Hearing Loss / pathology. Hearing Loss / physiopathology. Humans. Loss of Heterozygosity / genetics. Magnetic Resonance Imaging. Male. Middle Aged. Treatment Outcome

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  • (PMID = 15639530.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Rebol J, Milojković V, Didanovic V: Side-to-end hypoglossal-facial anastomosis via transposition of the intratemporal facial nerve. Acta Neurochir (Wien); 2006 Jun;148(6):653-7; discussion 657
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Side-to-end hypoglossal-facial anastomosis via transposition of the intratemporal facial nerve.
  • The technique of facial nerve repair with side-to-end hypoglossal-facial anastomosis is presented and evaluated in five patients who were operated on for facial nerve paralysis after acoustic schwannoma surgery, or had cranial base trauma.
  • In this new technique, the facial nerve is mobilised in the temporal bone, transected at the second genu and transposed to the hypoglossal nerve where a tensionless side-to-end anastomosis is performed.
  • The hypoglossal nerve is transected in oblique fashion to about one third of its circumference.
  • The idea is to bring about re-innervation of the previously denervated tissue via a collateral sprouting of axons of the donor nerve through the site of coaptation without sacrificing the innervation of the donor nerve's original targets.
  • [MeSH-major] Facial Nerve / surgery. Facial Nerve Diseases / surgery. Hypoglossal Nerve / surgery. Neurosurgical Procedures / methods. Reconstructive Surgical Procedures / methods
  • [MeSH-minor] Adult. Aged. Facial Muscles / innervation. Facial Muscles / physiopathology. Facial Nerve Injuries / physiopathology. Facial Nerve Injuries / surgery. Facial Paralysis / etiology. Facial Paralysis / physiopathology. Facial Paralysis / surgery. Female. Fibrin Tissue Adhesive / therapeutic use. Humans. Male. Middle Aged. Muscular Atrophy / etiology. Muscular Atrophy / physiopathology. Muscular Atrophy / prevention & control. Nerve Regeneration / physiology. Neuroma, Acoustic / complications. Neuroma, Acoustic / pathology. Neuroma, Acoustic / physiopathology. Neuronal Plasticity / physiology. Postoperative Complications / etiology. Postoperative Complications / physiopathology. Postoperative Complications / prevention & control. Recovery of Function / physiology. Sutures / standards. Temporal Bone / anatomy & histology. Temporal Bone / surgery. Tongue / innervation. Tongue / physiopathology. Treatment Outcome

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  • [CommentIn] Acta Neurochir (Wien). 2008 Jul;150(7):739-40 [18597056.001]
  • (PMID = 16493524.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Fibrin Tissue Adhesive
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32. Donzelli R, Maiuri F, Peca C, Cavallo LM, Motta G, de Divitiis E: Microsurgical repair of the facial nerve. Zentralbl Neurochir; 2005 May;66(2):63-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microsurgical repair of the facial nerve.
  • OBJECTIVE: To report a series of 18 patients who underwent microsurgical repair of the facial nerve using different techniques and to discuss the indications and results of facial reinnervation procedures.
  • 'These included classic hypoglossal-facial anastomosis in 13 cases, one-stage hemihypoglossal-intratemporal facial nerve anastomosis and translabyrinthine removal of residual intra-canalar acoustic schwannoma in 3, hemihypoglossal-facial nerve anastomosis in one, and neurotization of facial muscles through a nerve graft in one.
  • The use of the intratemporal facial nerve is indicated when removal of an intra-canalar residual schwannoma must also be performed.
  • The neurotization of the facial muscles through a nerve graft may be used when there is no distal trunk of the facial nerve available for the anastomosis.
  • [MeSH-major] Facial Nerve / surgery. Neurosurgical Procedures
  • [MeSH-minor] Adult. Anastomosis, Surgical. Atrophy. Ear, Inner / surgery. Facial Muscles / innervation. Facial Muscles / surgery. Facial Paralysis / etiology. Facial Paralysis / surgery. Female. Humans. Hypoglossal Nerve / surgery. Male. Microsurgery. Middle Aged. Nerve Tissue / transplantation. Neuroma, Acoustic / surgery. Postoperative Complications / etiology. Postoperative Complications / pathology. Postoperative Complications / surgery. Tongue / pathology. Tongue Diseases / etiology. Treatment Outcome

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  • (PMID = 15846533.001).
  • [ISSN] 0044-4251
  • [Journal-full-title] Zentralblatt für Neurochirurgie
  • [ISO-abbreviation] Zentralbl. Neurochir.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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33. Huang SQ, Liang BL, Yuan JP, Zhong JL: [MRI performance and diagnosis of schwannomas from cranial nerves in posterior cranial fossae]. Ai Zheng; 2006 Sep;25(9):1178-82
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  • [Title] [MRI performance and diagnosis of schwannomas from cranial nerves in posterior cranial fossae].
  • BACKGROUND & OBJECTIVE: Cranial nerve schwannomas originate frequently in posterior cranial fossae and have various and complex MRI performances, some of which are still not well known.
  • This study was to explore MRI performances and features of schwannomas from cranial nerves in posterior cranial fossae.
  • METHODS: The MRI performances of 75 cases of schwannoma from cranial nerves in posterior cranial fossae, including trigeminal (n=9), facial (n=1), acoustic (n=53), 9th-11th (n=9) and hypoglossal (n=3) schwannomas, confirmed by surgical and pathologic findings, were analyzed retrospectively.
  • RESULTS: Most of schwannomas in posterior cranial fossae were solid-cystic lesions when their sizes were larger than 1.5 cm in diameter.
  • On T1WI, the solid part of tumor appeared iso- or slightly hypointense, while cystic part was hypointense.
  • Some typical signs were very useful to infer tumor origin, such as, dumbbell-shaped trigeminal schwannoma extended across the middle and posterior cranial fossa, enlargement of internal auditory canal, widened jugular foramen and hypoglossal foramen caused by acoustic schwannoma, the 9th-11th shcwannoma, and hypoglossal schwannoma, respectively.
  • The correct ratio for qualitative diagnosis of schwannoma was 92% using MRI, but the incorrect ratio for identifying the nerve of tumor origin was 8.7%.
  • CONCLUSION: MRI is a good method in qualitative diagnosis of schwannoma and identifying cranial nerves of tumor origin in posterior cranial fossae.
  • [MeSH-major] Cranial Nerve Neoplasms / diagnosis. Magnetic Resonance Imaging. Neurilemmoma / diagnosis. Neuroma, Acoustic / diagnosis. Trigeminal Nerve Diseases / diagnosis

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  • (PMID = 16965666.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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34. Iwai Y, Yamanaka K, Yamagata K, Yasui T: Surgery after radiosurgery for acoustic neuromas: surgical strategy and histological findings. Neurosurgery; 2007 Feb;60(2 Suppl 1):ONS75-82; discussion ONS82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgery after radiosurgery for acoustic neuromas: surgical strategy and histological findings.
  • OBJECTIVE: To retrospectively review the authors' experience with surgical resections after failed radiosurgery for acoustic neuromas.
  • METHODS: The study group consisted of six patients with acoustic neuromas.
  • The operative indications were cerebellar ataxia and symptoms associated with increased intracranial pressure.
  • RESULTS: The tumors were subtotally removed (> or = 80%) in four patients and partially removed (< 80%) in the other two patients.
  • Preexisting facial nerve palsy improved in two patients and deteriorated in one patient, and one patient experienced new facial palsy.
  • Histological features were typical of acoustic schwannoma, and some tumors were associated with foamy macrophages, myxoid degeneration, and necrosis attributed to radiation effects.
  • At follow-up, the residual tumor was decreased in five patients and increased in one patient with an expanding intratumoral hematoma.
  • CONCLUSION: Surgical resection after radiosurgery is indicated in the presence of such symptoms as cerebellar ataxia and increased intracranial pressure.
  • It must be carefully considered because of the natural regression of transient tumor swelling over time.
  • In patients with tumor enlargement several years after radiosurgery, the possibility of chronic intratumoral bleeding resulting from delayed radiation injury must be considered.
  • [MeSH-major] Neoplasm Recurrence, Local / surgery. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Radiosurgery

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  • (PMID = 17297369.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Eisen MD, Smith PG, Judy KD, Bigelow DC: Cerebrospinal fluid cytology to aid the diagnosis of cerebellopontine angle tumors. Otol Neurotol; 2006 Jun;27(4):553-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cerebrospinal fluid cytology to aid the diagnosis of cerebellopontine angle tumors.
  • OBJECTIVE: To determine if cerebrospinal fluid (CSF) cytology can be useful in the workup of patients with internal auditory canal/cerebellopontine angle (IAC/CPA) tumors and facial paralysis to diagnose metastatic disease before surgical intervention.
  • PATIENTS: Patients who presented with or developed facial paralysis and IAC/CPA tumors.
  • In the first patient, excision of the tumor revealed adenocarcinoma.
  • In five of these patients, cytological CSF analysis revealed malignant cells, suggesting a diagnosis of a metastatic lesion rather than acoustic neuroma.
  • A sixth patient had metastatic breast cancer, but negative CSF cytology and a stable CPA tumor after radiation treatment.
  • Two patients who were being conservatively followed up for their IAC/CPA tumor developed a nonprogressive but persistent mild Grade II facial weakness and underwent CSF analysis which tested negative.
  • One patient had surgical resection with pathologic findings consistent with a typical acoustic schwannoma, and the other patient has been conservatively followed up without change.
  • CONCLUSION: Our experience suggests that patients presenting with IAC/CPA tumors and progressive facial paralysis of House-Brackmann Grade III or greater should have a CSF cytological examination before surgical intervention to evaluate for a malignant process.
  • [MeSH-minor] Aged. Dizziness / etiology. Facial Nerve / pathology. Facial Paralysis / etiology. Fatal Outcome. Female. Hearing Loss, Sensorineural / etiology. Hearing Loss, Sudden / etiology. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Spinal Puncture. Tinnitus / etiology

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  • (PMID = 16791049.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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36. Deinsberger R, Tidstrand J: Linac radiosurgery as a tool in neurosurgery. Neurosurg Rev; 2005 Apr;28(2):79-88; discussion 89-90, 91
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  • Stereotactic radiosurgery is a radiation technique that uses a high radiation dose focused on a stereotactic defined intracranial target in single fraction with high precision.
  • A number of 110 patients had 161 brain metastases treated, whereas the local tumor control rate was 89.4%.
  • Local tumor control rate in our patients with skull base meningiomas at 5-year follow up was 97.2%.
  • In this time period, we have also treated acoustic schwannoma, glioma, pituitary adenoma, arteriovenous malformations and patients with trigeminal neuralgia.
  • LINAC radiosurgery has become a daily tool in neurosurgery and changed treatment strategies especially in the treatment of brain metastases and skull base meningiomas towards a less aggressive and multimodality approach.
  • It is not only an alternative to open surgery, but also a very effective adjuvant treatment modality in many neuro-oncological patients, which helps us to enhance tumor control rate, minimize morbidity and increase postoperative quality of life.
  • [MeSH-major] Brain Neoplasms / surgery. Radiosurgery / methods
  • [MeSH-minor] Humans. Intracranial Arteriovenous Malformations / surgery. Radiotherapy, Computer-Assisted / methods. Treatment Outcome

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  • (PMID = 15726439.001).
  • [ISSN] 0344-5607
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 74
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37. Dizdarević K, Link MJ: [Operative treatment of the vestibular schwannoma (acoustic neuroma): correlation between the microsurgical approach and cranial nerve lesion]. Med Arh; 2005;59(3):160-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Operative treatment of the vestibular schwannoma (acoustic neuroma): correlation between the microsurgical approach and cranial nerve lesion].
  • [Transliterated title] Schwannoma vestibulare (neurinoma acustici)--operativni tretman: korelacija izmedu vrste mikroneurohirurskog pristupa i lezije kranijalnih nerava.
  • INTRODUCTION: Vestibular schwannoma (VS) is a benign tumour of cerebellopontine angle which total microsurgical resection is considered as a complex surgery.
  • Through analyzed series of operated patients (MJLink), we evaluated the correlation of VII and VIII nerves postoperative lesion with different operative approaches.
  • House-Brackmann grading scale is used for VII nerve deficit appraisal.
  • However, the most frequently used microsurgical approaches (retrosigmoid, translabyrinthine and extradural subtemporal) are still connected with certain morbidity rate, especially regarding the postoperative VII and VIII nerves lesion.
  • [MeSH-major] Microsurgery. Neuroma, Acoustic / surgery. Vestibulocochlear Nerve Injuries
  • [MeSH-minor] Facial Nerve Injuries / etiology. Humans. Intraoperative Complications


38. Zanetti D, Campovecchi CB, Pasini S, Nassif N: Simultaneous translabyrinthine removal of acoustic neuroma and cochlear implantation. Auris Nasus Larynx; 2008 Dec;35(4):562-8
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  • [Title] Simultaneous translabyrinthine removal of acoustic neuroma and cochlear implantation.
  • OBJECTIVES: To report of a 65-year-old woman with bilateral Meniere's disease was referred for cochlear implantation (CI) due to severe/profound sensorineural hearing loss.
  • METHODS: During the assessment workup, a vestibular schwannoma in the right ear was found by MR imaging.
  • She underwent a translabyrinthine removal of the acoustic neuroma (AN) with sparing of the cochlear nerve and concurrent ipsilateral CI with a Nucleus Freedom device (Cochlear Ltd., Lane Cove, New South Wales, Australia).
  • CONCLUSION: Cochlear implantation at the time of acoustic neuroma removal with VIII nerve sparing can be a safe and effective hearing restoration procedure.
  • [MeSH-major] Cochlear Implantation. Hearing Loss, Sensorineural / surgery. Neuroma, Acoustic / surgery
  • [MeSH-minor] Aged. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Meniere Disease / diagnosis. Speech Discrimination Tests

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  • (PMID = 18243617.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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39. Ambett R, Rupa V, Rajshekhar V: Analysis of causes for late presentation of Indian patients with vestibular schwannoma. J Laryngol Otol; 2009 May;123(5):502-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of causes for late presentation of Indian patients with vestibular schwannoma.
  • OBJECTIVE: To determine the causes of delay in diagnosis and treatment of Indian patients with vestibular schwannomas.
  • METHODS: In a prospective study from 2003 to 2005, 50 patients with a confirmed diagnosis of vestibular schwannoma were interviewed to determine the causes for (1) the delay between the patient noting the initial symptom and the definitive diagnosis, and (2) the reasons for delayed diagnosis.
  • After the patient had noted symptoms, the diagnosis of vestibular schwannoma was delayed due to doctor-related causes in 80 per cent of cases, and due to patient-related causes in 20 per cent.
  • CONCLUSIONS: Delay in the diagnosis of vestibular schwannoma in Indian patients is due to both doctor- and patient-related factors.
  • [MeSH-major] Hearing Loss, Sensorineural / etiology. Neuroma, Acoustic / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Disease Progression. Female. Health Knowledge, Attitudes, Practice. Humans. India. Male. Middle Aged. Prospective Studies. Referral and Consultation / standards. Time Factors. Tinnitus / etiology. Vertigo / etiology. Vestibular Function Tests. Young Adult

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  • (PMID = 18808730.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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40. Battista RA: Gamma knife radiosurgery for vestibular schwannoma. Otolaryngol Clin North Am; 2009 Aug;42(4):635-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gamma knife radiosurgery for vestibular schwannoma.
  • Since Leksell first treated a patient who had a vestibular schwannoma in 1967, there has been a year-to-year increase in the number of patients treated with the gamma knife for vestibular schwannoma.
  • This article outlines the technique of GKRS and discusses the current results of its use to treat vestibular schwannomas.
  • Other topics discussed include tumor control, treatment of recurrent/residual and cystic vestibular schwannomas, and the results of treatment of neurofibromatosis type 2.
  • [MeSH-major] Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Radiation Injuries / prevention & control. Radiosurgery / methods
  • [MeSH-minor] Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Neoplasm Invasiveness / pathology. Neoplasm Staging. Patient Selection. Postoperative Complications / mortality. Postoperative Complications / physiopathology. Radiotherapy Dosage. Radiotherapy Planning, Computer-Assisted. Risk Assessment. Survival Analysis. Treatment Outcome

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  • (PMID = 19751869.001).
  • [ISSN] 1557-8259
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 62
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41. Stangerup SE, Thomsen J, Tos M, Cayé-Thomasen P: Long-term hearing preservation in vestibular schwannoma. Otol Neurotol; 2010 Feb;31(2):271-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term hearing preservation in vestibular schwannoma.
  • OBJECTIVE: The aim of the present study was to evaluate the long-term hearing during "wait and scan" management of vestibular schwannomas.
  • SUBJECTS: During a 33-year period, from 1976 to 2008, 1,144 patients with vestibular schwannoma were allocated to observation by the wait and scan policy, with annual magnetic resonance imaging and audiologic examination.
  • CONCLUSION: Most vestibular schwannoma patients with 100% speech discrimination at diagnosis maintain good hearing even after many years of observation.
  • [MeSH-major] Hearing Loss / etiology. Hearing Loss / prevention & control. Neuroma, Acoustic / complications. Neuroma, Acoustic / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Audiometry, Pure-Tone. Databases, Factual. Denmark / epidemiology. Disease Progression. Female. Hearing / physiology. Humans. Male. Middle Aged. Speech Perception. Young Adult

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  • (PMID = 19887973.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Gharabaghi A, Samii A, Koerbel A, Rosahl SK, Tatagiba M, Samii M: Preservation of function in vestibular schwannoma surgery. Neurosurgery; 2007 Feb;60(2 Suppl 1):ONS124-7; discussion ONS127-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Preservation of function in vestibular schwannoma surgery.
  • The management and surgical technique for microsurgical tumor removal of vestibular schwannomas (acoustic neuroma) with the suboccipital retrosigmoid approach and semi-sitting patient positioning is described.
  • An emphasis is placed on the preservation of auditory and facial nerve function with a stepwise description of the technical and operative nuances, including presurgical evaluation, positioning, anesthesiological and neurophysiological aspects, approach, microsurgical techniques, and postsurgical care.
  • [MeSH-major] Microsurgery / methods. Neuroma, Acoustic / surgery. Neurosurgical Procedures / methods. Otologic Surgical Procedures / methods

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  • (PMID = 17297374.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 18
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43. Fukuda M, Oishi M, Kawaguchi T, Watanabe M, Takao T, Tanaka R, Fujii Y: Etiopathological factors related to hydrocephalus associated with vestibular schwannoma. Neurosurgery; 2007 Dec;61(6):1186-92; discussion 1192-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Etiopathological factors related to hydrocephalus associated with vestibular schwannoma.
  • OBJECTIVE: We retrospectively analyzed various clinical factors to determine whether or not these factors are etiopathologically related to the development of hydrocephalus in patients with vestibular schwannomas.
  • METHODS: There were 68 patients (29 men, 39 women) in this study who underwent resection of a vestibular schwannoma.
  • The maximum diameter of the tumor in the cerebellopontine cistern ranged from 0 (localized within the internal auditory canal) to 56 mm (mean, 32.0 +/- 12.9 mm).
  • Univariate analysis of various factors revealed that both tumor size and CSF protein concentration were positively related to development of hydrocephalus (P < 0.05 and P < 0.01, respectively).
  • There was a trend toward increased CSF protein concentration in patients with a large tumor (> or = 40 mm) compared with those with a small tumor (< 40 mm) (P = 0.06).
  • CONCLUSION: A high CSF protein concentration in fluid from the cerebellomedullary cistern is one of the most important factors contributing to hydrocephalus associated with vestibular schwannoma.
  • It is important to judge whether or not any further treatment is required for hydrocephalus, in addition to tumor resection, especially in patients with communicating hydrocephalus.
  • [MeSH-major] Brain Neoplasms / complications. Hydrocephalus / etiology. Hydrocephalus / pathology. Neuroma, Acoustic / complications


44. Zverina E: [Acoustic neuroma--vestibular schwannoma--personal experience of up-to-date management]. Cas Lek Cesk; 2010;149(6):269-76
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  • [Title] [Acoustic neuroma--vestibular schwannoma--personal experience of up-to-date management].
  • [Transliterated title] Neurinom akustiku--vestibulární schwannom--osobní pohled na nejmodernejsí postupy v jeho lécbe.
  • Acoustic neuroma, properly called vestibular schwannoma, arises from the Schwann cells of the vestibular transitional zone of the vestibulocochlear nerve as the most frequent tumour of the posterior fossa.
  • Its incidence is estimated at 1.2 vestibular schwannoma per a population of 100,000/year.
  • As to size, vestibular schwannoma is classified into grades I to IV.
  • About one third of small vestibular schwannoma show hardly any growth, the larger ones grow aggressively.
  • The author's conclusion is based on 33 years of experience with hundreds of surgically treated vestibular schwannoma (now at the ENT Department of Head and Neck Surgery, CU 1st Medical Faculty and FN Teaching Hospital, Prague Motol).
  • Irradiation for larger vestibular schwannoma is decreasingly efficacious.
  • 3. Microsurgery with intraoperative monitoring of facial and acoustic nerve function offers scope for radical removal of vestibular schwannoma of any size (grades I-IV) and for the preservation of facial nerve function and, of late, hearing, too.
  • [MeSH-major] Neuroma, Acoustic

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  • (PMID = 20662473.001).
  • [ISSN] 0008-7335
  • [Journal-full-title] Casopís lékar̆ů c̆eských
  • [ISO-abbreviation] Cas. Lek. Cesk.
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Czech Republic
  • [Number-of-references] 50
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45. Müller S, Arnolds J, van Oosterhout A: Decision-making of vestibular schwannoma patients. Acta Neurochir (Wien); 2010 Jun;152(6):973-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Decision-making of vestibular schwannoma patients.
  • BACKGROUND: Patients suffering from vestibular schwannoma can choose between four modalities of management:.
  • METHOD: This study is based on postal questionnaire survey of 739 vestibular schwannoma patients (survey response rate, 78%).
  • CONCLUSION: The praxis of patient counselling of acoustic neuroma patients in Germany is far from the ideal condition of medical consultation: The most important shortcoming is that it is unilateral: About 69% of the patients are informed about only one treatment option, generally surgery.
  • [MeSH-major] Decision Making. Dose Fractionation. Neuroma, Acoustic / radiotherapy. Neuroma, Acoustic / surgery. Patient Participation. Radiosurgery

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  • (PMID = 20169371.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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46. Chen L, Chen LH, Ling F, Liu YS, Samii M, Samii A: Removal of vestibular schwannoma and facial nerve preservation using small suboccipital retrosigmoid craniotomy. Chin Med J (Engl); 2010 Feb 5;123(3):274-80
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  • [Title] Removal of vestibular schwannoma and facial nerve preservation using small suboccipital retrosigmoid craniotomy.
  • BACKGROUND: Vestibular schwannoma, the commonest form of intracranial schwannoma, arises from the Schwann cells investing the vestibular nerve.
  • At present, the surgery for vestibular schwannoma remains one of the most complicated operations demanding for surgical skills in neurosurgery.
  • And the trend of minimal invasion should also be the major influence on the management of patients with vestibular schwannomas.
  • We summarized the microsurgical removal experience in a recent series of vestibular schwannomas and presented the operative technique and cranial nerve preservation in order to improve the rates of total tumor removal and facial nerve preservation.
  • METHODS: A retrospective analysis was performed in 145 patients over a 7-year period who suffered from vestibular schwannomas that had been microsurgically removed by suboccipital retrosigmoid transmeatus approach with small craniotomy.
  • CT thinner scans revealed the tumor size in the internal auditory meatus and the relationship of the posterior wall of the internal acoustic meatus to the bone labyrinths preoperatively.
  • Brain stem evoked potential was monitored intraoperatively.
  • The posterior wall of the internal acoustic meatus was designedly drilled off.
  • RESULTS: Total tumor resection was achieved in 140 cases (96.6%) and subtotal resection in 5 cases.
  • The anatomical integrity of the facial nerve was preserved in 91.0% (132/145) of the cases.
  • Intracranial end-to-end anastomosis of the facial nerve was performed in 7 cases.
  • Functional preservation of the facial nerve was achieved in 115 patients (Grade I and Grade II, 79.3%).
  • Preservation of nerves and vessels were as important as tumor removal during the operation.
  • CT thinner scan could show the relationship between the posterior wall of the internal acoustic meatus and bone labyrinths, that is helpful for a safe drilling of the posterior wall of the internal acoustic meatus.
  • Using the retrosigmoid approach with small craniotomy is possible even for large schwannomas.
  • Knowing the microanatomy of the cerebellopontine angle and internal auditory meatus, intraoperating neurophysiological monitoring of the facial nerve function, and the microsurgical techniques of the surgeons are all important factors for improving total tumor removal and preserving facial nerve function.
  • [MeSH-major] Craniotomy / methods. Facial Nerve / surgery. Neuroma, Acoustic / surgery

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  • (PMID = 20193244.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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47. Schoemaker MJ, Swerdlow AJ, Auvinen A, Christensen HC, Feychting M, Johansen C, Klaeboe L, Lönn S, Salminen T, Tynes T: Medical history, cigarette smoking and risk of acoustic neuroma: an international case-control study. Int J Cancer; 2007 Jan 1;120(1):103-10
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  • [Title] Medical history, cigarette smoking and risk of acoustic neuroma: an international case-control study.
  • Acoustic neuroma (vestibular schwannoma) is a benign tumor of the vestibulocochlear nerve.
  • Its recorded incidence is increasing but risk factors for this tumor have scarcely been investigated.
  • We conducted a population-based case-control study of risk factors for acoustic neuroma in the UK and Nordic countries, including 563 cases and 2,703 controls.
  • Tumor risk was analyzed in relation to medical history and cigarette smoking.
  • Risk of acoustic neuroma was significantly raised in parous compared with nulliparous women (OR = 1.7, 95% CI: 1.1-2.6), but was not related to age at first birth or number of children.
  • Risk was not associated with a history of allergic disease, past head injury, past diagnosis of a neoplasm or birth characteristics, but was significantly raised for past diagnosis of epilepsy (OR = 2.5, 95% CI: 1.3-4.9).
  • Tumor risk was significantly reduced in subjects who had ever regularly smoked cigarettes (OR = 0.7, 95% CI: 0.6-0.9), but the reduction applied only to current smokers (OR = 0.5, 95% CI: 0.4-0.6), not ex-smokers (OR = 1.0, 95% CI: 0.8-1.3).
  • The reduced risk of acoustic neuroma in smokers and raised risk in parous women might relate to sex hormone levels, or smoking might suppress tumor growth, but effects of parity and smoking on timing of diagnosis of the tumor are also a potential explanation.
  • The raised risk in relation to past diagnosis of epilepsy might be a surveillance artefact or imply that epilepsy and/or antiepileptic medication use predispose to acoustic neuroma.
  • [MeSH-major] Neuroma, Acoustic / etiology. Smoking / adverse effects


48. Koerbel A, Gharabaghi A, Safavi-Abbasi S, Tatagiba M, Samii M: Evolution of vestibular schwannoma surgery: the long journey to current success. Neurosurg Focus; 2005 Apr 15;18(4):e10
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  • [Title] Evolution of vestibular schwannoma surgery: the long journey to current success.
  • The extraordinary improvement of patient outcome after surgical treatment for vestibular schwannomas is relatively recent and has occurred mainly over the last 30 years.
  • Whereas in the past the primary goal of vestibular schwannoma management was to preserve the patient's life, the objective in vestibular schwannoma treatment today is to preserve neurological function.
  • Long-term follow-up examinations show negligible recurrence rates, indicating that the aim of preservation of nerve function does not limit the completeness of tumor removal with modern neurosurgical techniques.
  • Despite these advances in preserving the anatomical integrity of, for example, the cochlear nerve, losses of function and even deafness may occur postoperatively in some cases.
  • In this article, the authors report in detail the developments achieved in vestibular schwannoma surgery and the great clinicians to whom these results can be credited.
  • [MeSH-major] Microsurgery / history. Neuroma, Acoustic / history. Neuroma, Acoustic / surgery. Neurosurgery / history. Neurosurgical Procedures / history. Vestibulocochlear Nerve / surgery
  • [MeSH-minor] Deafness / etiology. Deafness / prevention & control. Facial Nerve Injuries / etiology. Facial Nerve Injuries / prevention & control. History, 18th Century. History, 19th Century. History, 20th Century. Humans. Neoplasm Recurrence, Local / prevention & control. Postoperative Complications / etiology. Postoperative Complications / pathology. Postoperative Complications / prevention & control. Vestibulocochlear Nerve Injuries

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  • (PMID = 15844862.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 70
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49. Goddard JC, Oliver ER, Lambert PR: Prevention of cerebrospinal fluid leak after translabyrinthine resection of vestibular schwannoma. Otol Neurotol; 2010 Apr;31(3):473-7
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  • [Title] Prevention of cerebrospinal fluid leak after translabyrinthine resection of vestibular schwannoma.
  • OBJECTIVE: Evaluate the rate of cerebrospinal fluid (CSF) leak after translabyrinthine craniotomy for the removal of vestibular schwannoma and describe details of closure technique.
  • PATIENTS: All individuals undergoing translabyrinthine craniotomy for removal of vestibular schwannoma from January 2000 to October 2008.
  • INTERVENTION: Translabyrinthine craniotomy for removal of vestibular schwannoma with abdominal fat graft harvest and layered closure.
  • RESULTS: Sixty-one patients underwent translabyrinthine craniotomy for the removal of vestibular schwannoma during a 9-year period.
  • CONCLUSION: Successful wound closure and CSF leak prevention after translabyrinthine craniotomy for the removal of vestibular schwannomas do not require the creation of a facial recess, manipulation of the ossicles, direct Eustachian tube plugging, or the use of alloplastic space-occupying materials.
  • [MeSH-major] Cerebrospinal Fluid Otorrhea / prevention & control. Cerebrospinal Fluid Rhinorrhea / prevention & control. Craniotomy / adverse effects. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / adverse effects. Vestibule, Labyrinth / surgery

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  • (PMID = 20084041.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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50. Sughrue ME, Yang I, Rutkowski MJ, Aranda D, Parsa AT: Preservation of facial nerve function after resection of vestibular schwannoma. Br J Neurosurg; 2010 Dec;24(6):666-71
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  • [Title] Preservation of facial nerve function after resection of vestibular schwannoma.
  • OBJECTIVE: Most data regarding facial nerve function in patients undergoing microsurgical resection of vestibular schwannomas predominantly include series performed at a single institution.
  • In an effort to minimise individual surgeon or institutional bias, we performed an analysis of the published literature on facial nerve outcomes following microsurgical resection of vestibular schwannomas.
  • The objective of this study was to provide a comprehensive assessment of reported outcomes for facial nerve preservation after VS surgery.
  • MATERIALS AND METHODS: We identified a total of 296 studies involving over 25,000 patients that included outcome data for facial nerve function of vestibular schwannoma patients treated surgically.
  • Data regarding surgical approach, tumour size, patient age, and use of intra-operative monitoring were extracted and correlated with facial nerve function after surgery.
  • Patients with preoperative facial nerve dysfunction (House-Brackmann score 3 or higher) were excluded and 'facial nerve preservation' was defined as grade I or II House-Brackmann function at last follow-up visit.
  • Patients treated with the middle cranial fossa approach had a trend towards higher overall facial nerve preservation rate (85%), compared to the translabyrinthine approach (81%, p = 0.07) , and did statistically better than the retrosigmoid approach (78%, p < 0.0001).
  • Patients with an average tumour size <20 mm had significantly improved facial nerve preservation rates, compared to larger tumours (90% vs. 67%, p < 0.0001).
  • Patients under 65 years of age had a lower facial nerve preservation rate (71% vs. 84%, p < 0.001).
  • Finally, the use of intra-operative monitoring improved the facial nerve preservation rate (76% vs. 71%, p < 0.001).
  • CONCLUSION: Factors that appear to be associated with facial nerve preservation after microsurgical resection of a vestibular schwannoma include tumour size <20 mm, use of the middle fossa approach and use of neuromonitoring during surgery.
  • These data provide a summary assessment of the published literature regarding facial nerve preservation after microsurgical resection of vestibular schwannoma.
  • [MeSH-major] Facial Nerve / physiopathology. Facial Nerve Injuries / prevention & control. Neuroma, Acoustic / physiopathology. Radiation Injuries / prevention & control. Radiosurgery / methods

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  • (PMID = 21070151.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
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51. Lassaletta L, Bello MJ, Del Río L, Alfonso C, Roda JM, Rey JA, Gavilan J: DNA methylation of multiple genes in vestibular schwannoma: Relationship with clinical and radiological findings. Otol Neurotol; 2006 Dec;27(8):1180-5
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  • [Title] DNA methylation of multiple genes in vestibular schwannoma: Relationship with clinical and radiological findings.
  • HYPOTHESIS: The purpose of this study was to examine the DNA methylation profile of several genes in a series of vestibular schwannomas, and to analyze its relationship with clinical and radiological features.
  • BACKGROUND: Aberrant methylation of promoter regions is a major mechanism for silencing of tumor suppressor genes in several tumors.
  • There is limited information about methylation status in vestibular schwannoma, with no clinical or radiological implications described to date.
  • METHODS: The methylation status of 16 tumor-related genes including RASSF1A, RAR-B, VHL, PTEN, HMLH1, RB1, TP16, CASP8, ER, TIMP3, MGMT, DAPK, TP73, GSTP1, TP14, and THBS1 was examined in a series of 22 vestibular schwannomas.The bisulfite modification of genomic DNA was performed.
  • Methylation of CASP8 was associated with the patient's age and the tumor size.
  • CONCLUSION: Aberrant methylation of tumor-related genes may play a role in the development of vestibular schwannomas.
  • Our results may provide useful clues to the development of prognostic assays for these tumors.
  • [MeSH-major] DNA Methylation. Neuroma, Acoustic / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Auditory Threshold / physiology. Female. Genes, Tumor Suppressor / physiology. Hearing Loss / genetics. Humans. Male. Middle Aged. Promoter Regions, Genetic / genetics


52. Mohammed TA, Ahuja MS, Ju SS, Thomas J: Normal pressure hydrocephalus after gamma knife radiosurgery for vestibular schwannoma. J Postgrad Med; 2010 Jul-Sep;56(3):213-5
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  • [Title] Normal pressure hydrocephalus after gamma knife radiosurgery for vestibular schwannoma.
  • Vestibular schwannomas are not uncommon, and gamma knife radiosurgery is one of the treatment options for symptomatic tumors.
  • Hydrocephalus is a complication of gamma knife treatment of vestibular schwannoma, though the mechanism of the development of hydrocephalus remains controversial.
  • We present an unusual case of normal pressure hydrocephalus (NPH) after gamma knife radiosurgery of a vestibular schwannoma in which the timeline of events strongly suggests that gamma knife played a contributory role in the development of the hydrocephalus.
  • [MeSH-major] Hydrocephalus, Normal Pressure / etiology. Neuroma, Acoustic / surgery. Radiosurgery / adverse effects


53. Khrais T, Romano G, Sanna M: Nerve origin of vestibular schwannoma: a prospective study. J Laryngol Otol; 2008 Feb;122(2):128-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nerve origin of vestibular schwannoma: a prospective study.
  • OBJECTIVE: The origin of vestibular schwannoma has always been a matter of debate.
  • The aim of our study was to identify the nerve origin of this tumour.
  • METHODS: A total of 200 cases of vestibular schwannoma were included in the study.
  • The origin of the tumour was limited to one nerve at the fundus in 152 cases (76 per cent).
  • Out of these cases, the tumour originated from the inferior vestibular nerve in 139 cases (91.4 per cent), from the superior vestibular nerve in nine cases (6 per cent), from the cochlear nerve in two cases (1.3 per cent) and from the facial nerve in two cases (1.3 per cent).
  • CONCLUSION: The vast majority of vestibular schwannomas originate from the inferior vestibular nerve; the incidence of involvement of this nerve increases as the tumour size increases.
  • An origin of vestibular schwannoma from the inferior vestibular nerve can be considered as one of the explanatory factors for the poor functional outcome of the extended middle cranial fossa approach, and probably accounts also for the better hearing preservation rate reported in some series for the retrosigmoid approach.
  • [MeSH-major] Neuroma, Acoustic / pathology. Otologic Surgical Procedures / methods. Vestibular Nerve / pathology
  • [MeSH-minor] Disease Progression. Female. Humans. Magnetic Resonance Imaging. Male. Prospective Studies

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  • (PMID = 18039415.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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54. Lee DJ, Maseyesva B, Westra W, Long D, Niparko JK, Califano J: Microsatellite analysis of recurrent vestibular schwannoma (acoustic neuroma) following stereotactic radiosurgery. Otol Neurotol; 2006 Feb;27(2):213-9
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  • [Title] Microsatellite analysis of recurrent vestibular schwannoma (acoustic neuroma) following stereotactic radiosurgery.
  • HYPOTHESIS: Genetic and immunohistochemical studies may provide insight into the mechanisms of vestibular schwannoma (VS) recurrence following radiation therapy.
  • BACKGROUND: Stereotactic radiation therapy is an increasingly common alternative to microsurgical resection for the primary management of sporadic vs. The molecular mechanisms associated with recurrent vestibular schwannoma (VS) following radiation therapy are not known.
  • METHODS: Primary or irradiated VS tumors were fresh-frozen at the time of surgical resection and microdissected to undergo DNA extraction.
  • Paired normal and tumor DNA specimens were analyzed for allelic loss by PCR amplification of polymorphic dinucleotide repeat sequences.
  • Deletions on chromosome 10 are seen in both benign and higher-grade meningiomas and intracranial malignancies associated with radiotherapy.
  • [MeSH-major] Chromosomes, Human, Pair 22. Microsatellite Repeats. Neoplasm Recurrence, Local / genetics. Neuroma, Acoustic / genetics. Neuroma, Acoustic / surgery. Radiosurgery
  • [MeSH-minor] Base Sequence. Chi-Square Distribution. Chromosomes, Human, Pair 10. DNA Mutational Analysis. DNA, Neoplasm / blood. DNA, Neoplasm / chemistry. DNA, Neoplasm / genetics. DNA, Neoplasm / isolation & purification. Gene Expression Regulation, Neoplastic. Genes, bcl-2 / genetics. Genes, p53 / genetics. Humans. Immunohistochemistry. Loss of Heterozygosity. Neurofibromin 2 / analysis. Neurofibromin 2 / genetics

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  • (PMID = 16436992.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Neurofibromin 2
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55. Coca Pelaz A, Fernández Lisa C, Gómez JR, Rodrigo JP, Llorente JL, Suárez C: [Complete facial palsy following surgery for acoustic nerve neurinoma: evolution and associated ophthalmological complications]. Acta Otorrinolaringol Esp; 2008 May;59(5):223-7
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  • [Title] [Complete facial palsy following surgery for acoustic nerve neurinoma: evolution and associated ophthalmological complications].
  • [Transliterated title] Parálisis facial completa tras cirugía de neurinoma del acústico: evolución y complicaciones oftalmológicas asociadas.
  • OBJECTIVE: To evaluate the fraction of patients recovering to normal function after complete facial nerve paralysis secondary to acoustic neuroma surgery, and also to address the ophthalmologic complications associated with it and the therapeutic options.
  • MATERIAL AND METHOD: We performed a retrospective review of 30 cases operated on in our department for acoustic neuroma and who, despite anatomical preservation of the facial nerve, developed a complete post-operative facial nerve paralysis (grade VI of House-Brackmann [HB]).
  • RESULTS: Only 5 of the 30 cases studied (16.6 %) recovered to normal facial nerve function (HB grade I).
  • [MeSH-major] Cochlear Nerve / pathology. Cochlear Nerve / surgery. Corneal Ulcer / etiology. Facial Paralysis / etiology. Facial Paralysis / physiopathology. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Peripheral Nervous System Neoplasms / pathology. Peripheral Nervous System Neoplasms / surgery. Postoperative Complications
  • [MeSH-minor] Adult. Aged. Disease Progression. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 18501157.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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56. Rutten I, Baumert BG, Seidel L, Kotolenko S, Collignon J, Kaschten B, Albert A, Martin D, Deneufbourg JM, Demanez JP, Stevenaert A: Long-term follow-up reveals low toxicity of radiosurgery for vestibular schwannoma. Radiother Oncol; 2007 Jan;82(1):83-9
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  • [Title] Long-term follow-up reveals low toxicity of radiosurgery for vestibular schwannoma.
  • AIM: The long-term effects of radiosurgery of vestibular schwannomas were investigated in a group of consecutively treated patients.
  • METHODS AND MATERIALS: Between 1995 and 2001, 26 patients (median age: 67, range: 30-82) with a vestibular schwannoma were treated by Linac-based stereotactic radiosurgery (SRS).
  • Five-year-probability of preservation of hearing and facial nerve function was 96% and 100%, respectively.
  • CONCLUSIONS: With the doses used, our study demonstrates that SRS provides an equivalent tumour control rate when compared to surgery, as well as on a long-term basis, an excellent preservation of the facial and the acoustic nerves.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / adverse effects

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  • (PMID = 17182142.001).
  • [ISSN] 0167-8140
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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57. Lü JR, Zou J, Wu H: [Expression and localization of merlin in vestibular schwannoma]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2006 Jul;41(7):501-5
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  • [Title] [Expression and localization of merlin in vestibular schwannoma].
  • OBJECTIVE: To clarify the expression and subcellular localization of merlin in vestibular schwannoma.
  • METHODS: Fifty four paraffin embedded vestibular schwannoma samples confirmed by pathology after resection were included in the study.
  • The expression of merlin in vestibular schwannoma was analyzed by immunohistochemistry.
  • Nerve tissues that were resected during surgical treatment for trigeminal neuralgia and Meniere's disease were used as control.
  • Western blotting was used to analyze the electrophoresis migration of merlin in the acoustic neuroma.
  • The expression percentage of merlin in the tumor tissue was compared with age and gender of the patients, clinical course of the tumor, tumor growth index, tumor diameter and clinical stage.
  • RESULTS: Merlin was expressed in 0 to 87.5% of the cells in vestibular schwannoma tissue with a mean of (46.66 +/- 5.75)%.
  • There was a negative correlation between merlin expression percentage and tumor growth index.
  • There were no correlations between merlin expression percentage and the age, gender, tumor diameter and clinical stage.
  • Merlin in the tumor tissue was shown by western blot to be in 65000 and 125000 positions.
  • CONCLUSIONS: Merlin was expressed in vestibular schwannoma tissue, with a different intra-cellular location.
  • Merlin might also exist as a complex with other proteins in the tumor tissue.
  • [MeSH-major] Neurofibromin 2 / metabolism. Neuroma, Acoustic / metabolism. Neuroma, Acoustic / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Young Adult

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  • (PMID = 17007372.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Neurofibromin 2
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58. Suryanarayanan R, Ramsden RT, Saeed SR, Aggarwal R, King AT, Rutherford SA, Evans DG, Gillespie JE: Vestibular schwannoma: role of conservative management. J Laryngol Otol; 2010 Mar;124(3):251-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vestibular schwannoma: role of conservative management.
  • OBJECTIVE: To assess the outcome of conservative management of vestibular schwannoma.
  • PATIENTS: Four hundred and thirty-six patients with vestibular schwannoma (490 tumours), including 327 sporadic tumours and 163 tumours in 109 patients with neurofibromatosis type two.
  • RESULTS: The initial tumour size was significantly larger in the neurofibromatosis type two group (11 mm) than in the sporadic vestibular schwannoma group (5.1 mm).
  • CONCLUSION: Two-thirds of vestibular schwannomas did not grow.
  • Once a sporadic vestibular schwannoma reaches 2 cm in intracranial diameter, it is likely to continue growing.
  • We do not recommend conservative management for sporadic tumours with an intracranial diameter of 1.5 cm or more.
  • Vestibular schwannoma management is more complex in patients with neurofibromatosis type two.
  • [MeSH-major] Neurofibromatosis 2 / therapy. Neuroma, Acoustic / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease Progression. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Risk Factors. Time Factors. Treatment Outcome. Tumor Burden. Young Adult

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  • (PMID = 20003606.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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59. Conley GS, Hirsch BE: Stereotactic radiation treatment of vestibular schwannoma: indications, limitations, and outcomes. Curr Opin Otolaryngol Head Neck Surg; 2010 Oct;18(5):351-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Stereotactic radiation treatment of vestibular schwannoma: indications, limitations, and outcomes.
  • PURPOSE OF REVIEW: Stereotactic radiation treatment is an increasingly performed procedure for patients with vestibular schwannoma and other benign skull base tumors.
  • The specific role of radiation in current management strategies for vestibular schwannoma continues to evolve as long-term outcome data are analyzed and standardized studies are performed.
  • Observation of small vestibular schwannomas is recommended over early radiation or microsurgical intervention.
  • Radiation may be used as adjunctive therapy for large tumors and in certain postradiation treatment failures.
  • Current evidence supports its use for small to medium sized primary and recurrent vestibular schwannomas with optimal dosing below 13 Gy.
  • It is also recommended for adjunctive therapy, recurrent tumors, in poor surgical candidates, and for those who do not desire observation or surgery.
  • [MeSH-major] Neuroma, Acoustic / radiotherapy. Radiosurgery. Skull Base Neoplasms / radiotherapy

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  • (PMID = 20613529.001).
  • [ISSN] 1531-6998
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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60. Lassaletta L, Gavilán J: [An update on the treatment of vestibular schwannoma]. Acta Otorrinolaringol Esp; 2009 Mar-Apr;60(2):131-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [An update on the treatment of vestibular schwannoma].
  • [Transliterated title] Actualización en el tratamiento del schwannoma vestibular.
  • The increase in the diagnosis of ever smaller vestibular schwannomas (VS), the fact that many tumours can be observed with serial MRI, and the development of radiosurgery as an alternative to microsurgery have led the neurotologic surgeon to a new global approach to patients with vs. On the other hand, the spread of internet-based information sources, often with biased or incomplete information, makes counselling patients with VS a challenging task.
  • [MeSH-major] Neuroma, Acoustic / therapy
  • [MeSH-minor] Disease Progression. Humans. Otologic Surgical Procedures / methods. Radiosurgery

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  • (PMID = 19401081.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 50
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61. Rutherford SA, King AT: Vestibular schwannoma management: What is the 'best' option? Br J Neurosurg; 2005 Aug;19(4):309-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vestibular schwannoma management: What is the 'best' option?
  • There is an abundance of medical literature describing the management options for vestibular schwannomas.
  • In this review, we set out what the aims of managing a vestibular schwannoma should be and compare how these different treatment modalities perform.
  • The particular objectives of tumour control, cranial nerve preservation, prevention of malignancy, quality of life and cost-effectiveness are discussed.
  • [MeSH-major] Neuroma, Acoustic / therapy
  • [MeSH-minor] Cost-Benefit Analysis. Disease Progression. Facial Paralysis / prevention & control. Hearing Disorders / prevention & control. Humans. Postoperative Complications / prevention & control. Quality of Life

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  • (PMID = 16455536.001).
  • [ISSN] 0268-8697
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 87
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62. Bisi MA, Selaimen CM, Chaves KD, Bisi MC, Grossi ML: Vestibular schwannoma (acoustic neuroma) mimicking temporomandibular disorders: a case report. J Appl Oral Sci; 2006 Dec;14(6):476-81

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vestibular schwannoma (acoustic neuroma) mimicking temporomandibular disorders: a case report.
  • Approximately 6 to 16% of patients with trigeminal neuralgia symptoms present intracranial tumors, the most common being the vestibular schwannoma (acoustic neuroma).
  • In these cases, magnetic resonance imaging (MRI) has proved to be a useful tool in tumor diagnosis.
  • The purpose of this paper is to demonstrate the relationship among trigeminal neuralgia symptoms, intracranial tumors and temporomandibular dysfunction by presenting a clinical case.

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  • (PMID = 19089251.001).
  • [ISSN] 1678-7765
  • [Journal-full-title] Journal of applied oral science : revista FOB
  • [ISO-abbreviation] J Appl Oral Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
  • [Other-IDs] NLM/ PMC4327303
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63. Bian LG, Tirakotai W, Sun QF, Zhao WG, Shen JK, Luo QZ: Molecular genetics alterations and tumor behavior of sporadic vestibular schwannoma from the People's Republic of China. J Neurooncol; 2005 Jul;73(3):253-60
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  • [Title] Molecular genetics alterations and tumor behavior of sporadic vestibular schwannoma from the People's Republic of China.
  • OBJECTIVES: To analyze the molecular genetic alteration of sporadic vestibular schwannomas from the People's Republic of China and to correlate these alterations with the tumor behaviors.
  • The proliferative index (LI) of vestibular schwannoma was evaluated by proliferative cell nuclear antigen investigation.
  • RESULTS: Sixteen vestibular schwannomas (44.4%) showed allele loss.
  • We found 22 mutations in 36 schwannomas.
  • The LI and the growth rate of schwannomas with LOH or mutation were significantly higher than those without LOH or mutation.
  • All of these vestibular schwannomas showed no immunoreaction to anti-NF2(A-19) IgG by immunohistochemistry.
  • By immunoblotting technique, reduced expression of S/M was found in 31 cases (86%).
  • The growth index of schwannomas with severely reduced expression of S/M was significantly higher than those with moderately reduced or normal expression.
  • CONCLUSION: The molecular genetic changes in sporadic vestibular schwannomas from Chinese patients were similar to the previous reports.
  • We demonstrate the relationship between tumor behaviors and genetic alteration (including LOH and mutation of NF2 gene).
  • We propose that inactivation of S/M, may be an important step in tumorigenesis of sporadic vestibular schwannoma.
  • [MeSH-major] Chromosomes, Human, Pair 22 / genetics. Genes, Neurofibromatosis 2. Neuroma, Acoustic / genetics. Neuroma, Acoustic / metabolism

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  • (PMID = 15980976.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Neurofibromin 2
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64. Solares CA, Panizza B: Vestibular schwannoma: an understanding of growth should influence management decisions. Otol Neurotol; 2008 Sep;29(6):829-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vestibular schwannoma: an understanding of growth should influence management decisions.
  • BACKGROUND: Treatments for vestibular schwannomas include surgical removal and radiotherapy.
  • Observation is a reasonable alternative, given the slow growth of these tumors.
  • METHODS: Patients with unilateral vestibular schwannomas who presented in the last 10 years were reviewed.
  • The following information was recorded from the charts: age, sex, tumor size at presentation and subsequent follow-up sessions, treatment in the event of growth, and time interval between presentation and last imaging available.
  • Interestingly, 11 patients (10%) demonstrated tumor regression.
  • Patients with intracanalicular tumors had a 5-year no-growth rate of 89.8% compared with 73.9% and 45.2% for Grade I and Grade II or larger tumors, respectively.
  • The difference between intracanalicular and Grade II or larger tumors was statistically significant (p = 0.0196).
  • CONCLUSION: Our data suggest that treatment can be delayed in a large proportion of vestibular schwannoma patients and that this is particularly true in patients with small tumors.
  • [MeSH-major] Ear Neoplasms / radiotherapy. Ear Neoplasms / surgery. Neuroma, Acoustic / radiotherapy. Neuroma, Acoustic / surgery

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  • (PMID = 18636034.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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65. Chang LS, Welling DB: Molecular biology of vestibular schwannomas. Methods Mol Biol; 2009;493:163-77
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular biology of vestibular schwannomas.
  • Recent advances in molecular biology have led to a better understanding of the etiology of vestibular schwannomas.
  • The underlying purpose of vestibular schwannoma research is the development of new treatment options; however, such options have not yet been established.
  • A fundamental understanding of the underlying molecular events leading to tumor formation began when mutations in the neurofibromatosis type 2 (NF2) tumor suppressor gene were identified in vestibular schwannomas.
  • The clinical characteristics of vestibular schwannomas and neurofibromatosis type 2 (NF2) syndromes have both been related to alterations in the NF2 gene.
  • When utilized with clinical screening, such as magnetic resonance imaging (MRI), conventional audiometry, and auditory brainstem response (ABR), the early detection of NF2 can be made, which consequently makes a significant difference in the ability to successfully treat vestibular schwannomas.
  • Nf2-transgenic and knockout mice as well as vestibular schwannoma xenograft models are now ready for novel therapeutic testing.
  • [MeSH-major] Mutation. Neurofibromin 2 / genetics. Neuroma, Acoustic / genetics
  • [MeSH-minor] Animals. DNA Mutational Analysis. Genetic Predisposition to Disease. Humans. Magnetic Resonance Imaging. Mice. Mice, Knockout. Mice, SCID. Mice, Transgenic. Neurofibromatosis 2 / genetics. Neurofibromatosis 2 / pathology

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  • (PMID = 18839347.001).
  • [ISSN] 1064-3745
  • [Journal-full-title] Methods in molecular biology (Clifton, N.J.)
  • [ISO-abbreviation] Methods Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neurofibromin 2
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66. Stangerup SE, Caye-Thomasen P, Tos M, Thomsen JC: [Incidence of vestibular schwannoma in Denmark]. Ugeskr Laeger; 2008 Oct 13;170(42):3335-8
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  • [Title] [Incidence of vestibular schwannoma in Denmark].
  • INTRODUCTION: During the last 30 years the number of diagnosed vestibular schwannomas (VS) has increased from 15 in 1976 to 116 in 2006.
  • CONCLUSION: With easier access to MRI, vestibular schwannomas are found earlier when they are still small.
  • [MeSH-major] Neuroma, Acoustic / epidemiology

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  • (PMID = 18940171.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Denmark
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67. Stangerup SE, Tos M, Thomsen J, Caye-Thomasen P: True incidence of vestibular schwannoma? Neurosurgery; 2010 Nov;67(5):1335-40; discussion 1340
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] True incidence of vestibular schwannoma?
  • BACKGROUND: The incidence of diagnosed sporadic unilateral vestibular schwannomas (VS) has increased, due primarily to more widespread access to magnetic resonance imaging.
  • OBJECTIVE: To present updated epidemiological data on VS incidence, as well as patient age, hearing acuity, tumor size, and localization at diagnosis for the last 4 decades in an unselected population, with emphasis on developments in recent years.
  • Incidence during the period, patient sex and age, data on hearing (pure tone average and speech discrimination), and tumor size at diagnosis were retrieved from the database.
  • Mean tumor size at diagnosis decreased from 30 mm in 1979 to 10 mm in 2008, whereas hearing acuity at diagnosis has improved over the years.
  • CONCLUSION: After a steady increase over the last 4 decades, the incidence of vestibular schwannomas appears to have peaked and decreased in recent years, stabilizing at about 19 tumors per million per year.
  • Whereas the sex ratio and age at diagnosis have remained grossly unchanged over the years, hearing has improved, and tumor size has decreased considerably.
  • [MeSH-major] Neuroma, Acoustic / epidemiology

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  • (PMID = 20871439.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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68. Niu Y, Ma L, Mao Q, Wu L, Chen J: Pituitary adenoma and vestibular schwannoma: case report and review of the literature. J Postgrad Med; 2010 Oct-Dec;56(4):281-3
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  • [Title] Pituitary adenoma and vestibular schwannoma: case report and review of the literature.
  • The concurrence of the intracranial multiple primary tumors (MPTs) consisting of acoustic neuroma (AN) and pituitary adenoma is very rare.
  • The model also indicates that when a pituitary tumor or AN is detected separately, we might consider the development of "expanding field" after oncological treatment especially after radiotherapy in order to prevent the second field tumor occurring.
  • [MeSH-major] Adenoma / pathology. Neoplasms, Multiple Primary / pathology. Neuroma, Acoustic / pathology. Pituitary Neoplasms / pathology

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  • (PMID = 20935399.001).
  • [ISSN] 0972-2823
  • [Journal-full-title] Journal of postgraduate medicine
  • [ISO-abbreviation] J Postgrad Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
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69. Cauley KA, Ratkovits B, Braff SP, Linnell G: Communicating hydrocephalus after gamma knife radiosurgery for vestibular schwannoma: an MR imaging study. AJNR Am J Neuroradiol; 2009 May;30(5):992-4
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  • [Title] Communicating hydrocephalus after gamma knife radiosurgery for vestibular schwannoma: an MR imaging study.
  • Vestibular schwannomas are common, and gamma knife radiosurgery is a treatment option of symptomatic tumors.
  • Hydrocephalus may be a complication of gamma knife treatment of vestibular schwannoma, though the cause-and-effect relationship can be debated because tumors can cause hydrocephalus without treatment.
  • We present an MR imaging study of an unusual case of communicating hydrocephalus after gamma knife radiosurgery of a vestibular schwannoma in which the timeline of events strongly suggests that gamma knife played a contributory role in the development of hydrocephalus.
  • [MeSH-major] Hydrocephalus / etiology. Hydrocephalus / pathology. Magnetic Resonance Imaging / methods. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Radiosurgery / adverse effects


70. Sughrue ME, Yang I, Han SJ, Aranda D, Kane AJ, Amoils M, Smith ZA, Parsa AT: Non-audiofacial morbidity after Gamma Knife surgery for vestibular schwannoma. Neurosurg Focus; 2009 Dec;27(6):E4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Non-audiofacial morbidity after Gamma Knife surgery for vestibular schwannoma.
  • OBJECT: While many studies have been published outlining morbidity following radiosurgical treatment of vestibular schwannomas, significant interpractitioner and institutional variability still exists.
  • For this reason, the authors conducted a systematic review of the literature for non-audiofacial-related morbidity after the treatment of vestibular schwannoma with radiosurgery.
  • METHODS: The authors performed a comprehensive search of the English-language literature to identify studies that published outcome data of patients undergoing radiosurgery treatment for vestibular schwannomas.
  • All tumors included in this study were < 25 mm in their largest diameter.
  • Patients receiving > 13 Gy were significantly more likely to develop trigeminal nerve neuropathy than those receiving < 13 Gy (p < 0.001).
  • CONCLUSIONS: The results of our review of the literature provide a systematic summary of the published rates of nonaudiofacial morbidity following radiosurgery for vestibular schwannoma.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / methods
  • [MeSH-minor] Cranial Nerve Diseases / epidemiology. Cranial Nerve Diseases / etiology. Humans. Hydrocephalus / epidemiology. Hydrocephalus / etiology. Hydrocephalus / surgery. Postoperative Complications / epidemiology. Postoperative Complications / etiology. Postoperative Complications / mortality. Radiation Dosage. Radiotherapy Dosage / standards. Tinnitus / epidemiology. Tinnitus / etiology. Treatment Outcome. Trigeminal Nerve Diseases / epidemiology. Trigeminal Nerve Diseases / etiology. Trigeminal Neuralgia / epidemiology. Trigeminal Neuralgia / etiology. Vertigo / epidemiology. Vertigo / etiology

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  • (PMID = 19951057.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Grant] United States / Howard Hughes Medical Institute / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 87
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71. Mandl ES, Vandertop WP, Meijer OW, Peerdeman SM: Imaging-documented repeated intratumoral hemorrhage in vestibular schwannoma: a case report. Acta Neurochir (Wien); 2009 Oct;151(10):1325-7
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  • [Title] Imaging-documented repeated intratumoral hemorrhage in vestibular schwannoma: a case report.
  • Intratumoral hemorrhage in vestibular schwannomas is rare.
  • Intratumoral hemorrhage is probably caused by vascular fragility associated with tumor characteristics and growth.
  • The present report details the case of acute neurological deterioration in a patient with repeated intratumoral hemorrhage inside a vestibular schwannoma with computed tomography and magnetic resonance imaging confirmation.
  • To our knowledge, repeated hemorrhage in vestibular schwannoma with radiological confirmation has not been reported before.
  • [MeSH-major] Cerebellopontine Angle / pathology. Intracranial Hemorrhages / diagnosis. Intracranial Hemorrhages / etiology. Neuroma, Acoustic / complications. Neuroma, Acoustic / diagnosis. Vestibular Nerve / pathology
  • [MeSH-minor] Disease Progression. Facial Nerve Injuries / etiology. Female. Humans. Hydrocephalus / etiology. Hydrocephalus / pathology. Hydrocephalus / surgery. Magnetic Resonance Imaging. Middle Aged. Neurosurgical Procedures. Postoperative Complications. Radiotherapy. Tomography, X-Ray Computed. Treatment Outcome. Ventriculoperitoneal Shunt

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  • [Cites] Neurosurgery. 2003 Aug;53(2):282-87; discussion 287-8 [12925242.001]
  • [Cites] Clin Neurol Neurosurg. 1998 Mar;100(1):68-74 [9637211.001]
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  • [Cites] Neurol Med Chir (Tokyo). 1989 Apr;29(4):328-32 [2478916.001]
  • (PMID = 19255715.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
  • [Other-IDs] NLM/ PMC2760714
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72. Djalilian HR, Benson AG, Ziai K, Safai Y, Thakkar KH, Mafee MF: Radiation necrosis of the brain after radiosurgery for vestibular schwannoma. Am J Otolaryngol; 2007 Sep-Oct;28(5):338-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiation necrosis of the brain after radiosurgery for vestibular schwannoma.
  • OBJECTIVE: The objective of this study was to obtain a better understanding of radiation-induced brain necrosis after stereotactic radiation therapy for vestibular schwannomas.
  • MAIN OUTCOME MEASURE: The outcome measure that we evaluated was radiation-induced necrosis of the brain after stereotactic radiation therapy for a vestibular schwannoma.
  • RESULTS: Patients who undergo stereotactic radiation therapy for vestibular schwannomas are at risk for radiation-induced brain necrosis.
  • CONCLUSION: We support the development of a national database that would track the long-term complications of stereotactic radiation therapy to help patients make a more informed decision for the treatment of their vestibular schwannomas.
  • [MeSH-major] Brain Injuries / etiology. Neuroma, Acoustic / surgery. Radiation Injuries / etiology. Radiosurgery / adverse effects

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  • (PMID = 17826537.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Park HY, Kim SH, Son EJ, Lee HK, Lee WS: Intracanalicular facial nerve schwannoma. Otol Neurotol; 2007 Apr;28(3):376-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intracanalicular facial nerve schwannoma.
  • OBJECTIVE: To investigate the capability of preoperative evaluations in predicting the precise anatomic origin of intracanalicular tumors.
  • PATIENTS: A total of 11 patients (8 men and 3 women, 26-70 years old) with intracanalicular tumors who were treated surgically were included.
  • MAIN OUTCOME MEASURE: Preoperative symptoms, pure-tone average, auditory brainstem response, caloric test, electroneuronography, and magnetic resonance imaging were compared between patients with facial nerve schwannomas and patients with vestibular schwannomas.
  • RESULTS: Postoperatively, facial nerve schwannomas were diagnosed pathologically in 2 (18%) of 11 patients.
  • There were not any clues suggesting facial nerve schwannoma in preoperative evaluations.
  • CONCLUSION: A facial nerve schwannoma may be misdiagnosed as a vestibular schwannoma, especially when the tumor is confined to the internal auditory canal.
  • There are no useful preoperative evaluation tools in predicting the precise nerve origin of intracanalicular tumors.
  • [MeSH-major] Cranial Nerve Neoplasms / pathology. Facial Nerve / pathology. Neurilemmoma / pathology
  • [MeSH-minor] Adult. Aged. Audiometry, Pure-Tone. Diagnosis, Differential. Ear, Inner. Evoked Potentials, Auditory, Brain Stem / physiology. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neuroma, Acoustic / pathology. Otologic Surgical Procedures. Retrospective Studies

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  • (PMID = 17414044.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Samii A, Lenarz M, Majdani O, Lim HH, Samii M, Lenarz T: Auditory midbrain implant: a combined approach for vestibular schwannoma surgery and device implantation. Otol Neurotol; 2007 Jan;28(1):31-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Auditory midbrain implant: a combined approach for vestibular schwannoma surgery and device implantation.
  • HYPOTHESIS: The lateral suboccipital approach is a well-established route for safe removal of vestibular schwannomas in neurofibromatosis Type 2 (NF2) patients.
  • The initial candidates are NF2 patients who, because of the growth and/or surgical removal of bilateral acoustic neuromas, develop neural deafness and are unable to benefit from cochlear implants.
  • The ideal surgical approach in NF2 patients must first enable safe removal of vestibular schwannomas and then provide sufficient exposure of the midbrain for AMI implantation.
  • RESULTS: The lateral suboccipital craniotomy enabled sufficient exposure of the cerebellopontine angle and internal auditory canal for tumor removal.
  • This approach did not endanger the trochlear nerve or any major midline venous structures in the quadrigeminal cistern.
  • CONCLUSION: This modified lateral suboccipital approach ensures safe removal of large vestibular schwannomas and provides sufficient exposure of the inferior colliculus for ideal AMI implantation.
  • [MeSH-major] Auditory Brain Stem Implants. Deafness / etiology. Deafness / surgery. Neuroma, Acoustic / complications. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods

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  • (PMID = 17195743.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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75. Cardoso AC, Fernandes YB, Ramina R, Borges G: Acoustic neuroma (vestibular schwannoma): surgical results on 240 patients operated on dorsal decubitus position. Arq Neuropsiquiatr; 2007 Sep;65(3A):605-9
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  • [Title] Acoustic neuroma (vestibular schwannoma): surgical results on 240 patients operated on dorsal decubitus position.
  • OBJECTIVE: To evaluate the result of the surgical treatment of vestibular schwannoma (VS) operated in dorsal decubitus (mastoid position).
  • METHOD: 240 patients with a VS underwent a retrosigmoid craniotomy for tumor resection in dorsal decubitus (mastoid position).
  • RESULTS: Complete tumor removal was achieved in 99% of the cases, with a mortality of 1.6%.
  • The facial nerve function was preserved in 85% of cases and hearing in 40% of the patients (with preoperative hearing) with tumors of up 1.5 cm in diameter.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Craniotomy / standards. Neuroma, Acoustic / surgery. Supine Position. Vestibulocochlear Nerve / surgery. Vestibulocochlear Nerve Diseases / surgery

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  • (PMID = 17876399.001).
  • [ISSN] 0004-282X
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Fibrin Tissue Adhesive; 0 / Tissue Adhesives
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76. Coca Pelaz A, Rodrigo JP, Llorente JL, Gómez JR, Suárez C: [Unusual clinical presentations of vestibular schwannomas]. Acta Otorrinolaringol Esp; 2008 Apr;59(4):187-9
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  • [Title] [Unusual clinical presentations of vestibular schwannomas].
  • [Transliterated title] Formas clínicas inusuales de presentación de los neurinomas del acústico.
  • The aim of this study is evaluate the unusual ways of initial presentation of the vestibular schwannomas.
  • We performed a retrospective study of the patients who underwent resection of acoustic neuromas on our service, including for analysis only the cases which initial symptom was not the hearing loss.
  • Tumor size, localization, clinical presentation, and age of the patients were considered.
  • A significant group of patients did not present with the otological symptoms classically associated with vestibular schwannoma.
  • [MeSH-major] Cerebellopontine Angle / pathology. Hearing Loss / etiology. Neuroma, Acoustic / complications. Neuroma, Acoustic / pathology

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  • (PMID = 18447978.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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77. Nouraei SA, Huys QJ, Chatrath P, Powles J, Harcourt JP: Screening patients with sensorineural hearing loss for vestibular schwannoma using a Bayesian classifier. Clin Otolaryngol; 2007 Aug;32(4):248-54
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  • [Title] Screening patients with sensorineural hearing loss for vestibular schwannoma using a Bayesian classifier.
  • OBJECTIVES: Selecting patients with asymmetrical sensorineural hearing loss for further investigation continues to pose clinical and medicolegal challenges, given the disparity between the number of symptomatic patients, and the low incidence of vestibular schwannoma as the underlying cause.
  • We developed and validated a diagnostic model using a generalisation of neural networks, for detecting vestibular schwannomas from clinical and audiological data, and compared its performance with six previously published clinical and audiological decision-support screening protocols.
  • PARTICIPANTS: Clinical and audiometric details of 129 patients with, and as many age and sex-matched patients without vestibular schwannomas, as determined with magnetic resonance imaging.
  • MAIN OUTCOME MEASURES: The ability to diagnose a patient as having or not having vestibular schwannoma.
  • RESULTS: A Gaussian Process Ordinal Regression Classifier was trained and cross-validated to classify cases as 'with' or 'without' vestibular schwannoma, and its diagnostic performance was assessed using receiver operator characteristic plots.
  • DISCUSSION: The Gaussian Process ORdinal Regression Classifier increased the flexibility and specificity of the screening process for vestibular schwannoma when applied to a sample of matched patients with and without this condition.
  • [MeSH-major] Hearing Loss, Sensorineural / diagnosis. Hearing Loss, Sensorineural / etiology. Neuroma, Acoustic / complications. Neuroma, Acoustic / diagnosis

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  • (PMID = 17651265.001).
  • [ISSN] 1749-4478
  • [Journal-full-title] Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • [ISO-abbreviation] Clin Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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78. Ito E, Saito K, Yatsuya H, Nagatani T, Otsuka G: Factors predicting growth of vestibular schwannoma in neurofibromatosis type 2. Neurosurg Rev; 2009 Oct;32(4):425-33
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  • [Title] Factors predicting growth of vestibular schwannoma in neurofibromatosis type 2.
  • We retrospectively reviewed characteristics of patients with neurofibromatosis type 2 to identify factors predicting further growth of bilateral vestibular schwannomas.
  • Subjects comprised 27 neurofibromatosis type 2 patients with 54 vestibular schwannomas, followed for 24-204 months (mean, 86 months).
  • This study investigated factors predictive of vestibular schwannoma growth in neurofibromatosis type 2.
  • Features distinguishing actively growing from quiescent VS were determined for untreated course (28 vestibular schwannomas) and posttreatment course (including either resection or radiosurgery; 33 vestibular schwannomas).
  • A general estimation equation was used to identify factors affecting tumor growth.
  • During the untreated course, 19 vestibular schwannomas showed growth and 9 vestibular schwannomas were stable.
  • [MeSH-major] Cranial Nerve Neoplasms / pathology. Neurofibromatosis 2 / pathology. Neuroma, Acoustic / pathology. Trigeminal Nerve / pathology
  • [MeSH-minor] Adolescent. Adult. Age of Onset. Analysis of Variance. Child. Child, Preschool. Disease Progression. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neurosurgical Procedures. Predictive Value of Tests. Radiosurgery. Retrospective Studies. Tomography, X-Ray Computed. Young Adult


79. Roser F, Tatagiba MS: The first 50s: can we achieve acceptable results in vestibular schwannoma surgery from the beginning? Acta Neurochir (Wien); 2010 Aug;152(8):1359-65
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  • [Title] The first 50s: can we achieve acceptable results in vestibular schwannoma surgery from the beginning?
  • OBJECTIVE: Vestibular schwannoma surgery requires a profound knowledge of anatomy and long-standing experience of surgical skull base techniques, as patients nowadays requests high-quality results from any surgeon.
  • METHODS: The first 50 vestibular schwannomas of the first author were retrospectively evaluated concerning morbidity and mortality with an emphasis on functional cranial nerve preservation.
  • RESULTS: Fifty vestibular schwannomas were consecutively operated from July 2007 to January 2010.
  • The overall facial nerve preservation rate was 96%.
  • Hearing preservation in T1/2 schwannomas was achieved in 66%, in patients with T3 tumours in 56%, and in large T4 tumours in 25%.
  • [MeSH-major] Education, Medical, Graduate / standards. Neuroma, Acoustic / surgery. Neurosurgical Procedures / adverse effects. Neurosurgical Procedures / mortality. Postoperative Complications / epidemiology. Postoperative Complications / prevention & control
  • [MeSH-minor] Adult. Aged. Female. Humans. Iatrogenic Disease / prevention & control. Male. Middle Aged. Outcome Assessment (Health Care) / methods. Retrospective Studies. Treatment Outcome

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  • (PMID = 20440629.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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80. Shih C, Tseng FY, Yeh TH, Hsu CJ, Chen YS: Ipsilateral and contralateral acoustic brainstem response abnormalities in patients with vestibular schwannoma. Otolaryngol Head Neck Surg; 2009 Dec;141(6):695-700
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  • [Title] Ipsilateral and contralateral acoustic brainstem response abnormalities in patients with vestibular schwannoma.
  • OBJECTIVE: To analyze auditory brainstem response (ABR) data in patients with vestibular schwannomas (VS) in an effort to identify correlations between abnormal ABR parameters and tumor size.
  • Average VS tumor size was 2.48 +/- 1.31 cm.
  • Tumor size was positively correlated with pure-tone average (P = 0.0106) and with the total number of bilateral abnormal ABR parameters (P = 0.004).
  • CONCLUSIONS: We identified a correlation between ABR parameters and VS tumor size.
  • An ipsilateral ILD-I-V greater than 0.2 ms was sensitive for detecting vs. Abnormal contralateral wave V and interpeak III-V latency indicated a tumor size potentially larger than 2 cm.
  • [MeSH-major] Evoked Potentials, Auditory, Brain Stem / physiology. Neuroma, Acoustic / physiopathology
  • [MeSH-minor] Adolescent. Adult. Aged. Audiometry, Pure-Tone. Cross-Sectional Studies. Female. Humans. Linear Models. Male. Middle Aged. Retrospective Studies. Vestibular Function Tests

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  • (PMID = 19932840.001).
  • [ISSN] 1097-6817
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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81. Sweeney P, Yajnik S, Hartsell W, Bovis G, Venkatesan J: Stereotactic radiotherapy for vestibular schwannoma. Otolaryngol Clin North Am; 2009 Aug;42(4):655-63
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  • [Title] Stereotactic radiotherapy for vestibular schwannoma.
  • Vestibular schwannomas are benign tumors of the Schwann cells of the eighth (VIII) cranial nerve.
  • Precision radiotherapy techniques used to manage these tumors include stereotactic radiotherapy (SRT), which can be delivered with either a conventional or hypofractionated regimen.
  • [MeSH-major] Neoplasm Recurrence, Local / pathology. Neuroma, Acoustic / radiotherapy. Radiation Injuries / prevention & control. Radiotherapy Planning, Computer-Assisted. Stereotaxic Techniques
  • [MeSH-minor] Animals. Biopsy, Needle. Dose Fractionation. Dose-Response Relationship, Radiation. Female. Humans. Immunohistochemistry. Male. Mice. Neoplasm Staging. Prognosis. Radiobiology. Radiosurgery / adverse effects. Radiosurgery / methods. Radiotherapy Dosage. Radiotherapy, Conformal / adverse effects. Radiotherapy, Conformal / methods. Risk Assessment. Survival Analysis. Treatment Outcome

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  • (PMID = 19751870.001).
  • [ISSN] 1557-8259
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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82. Agrawal Y, Clark JH, Limb CJ, Niparko JK, Francis HW: Predictors of vestibular schwannoma growth and clinical implications. Otol Neurotol; 2010 Jul;31(5):807-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Predictors of vestibular schwannoma growth and clinical implications.
  • OBJECTIVE: Vestibular schwannomas exhibit variable and unpredictable patterns of growth.
  • We evaluated the extent to which tumor growth influences the management of these benign tumors, and we explored symptom markers present at diagnosis that may be predictive of tumor growth.
  • PATIENTS: One hundred eighty patients with unilateral vestibular schwannomas diagnosed between 1997 and 2007 who were initially managed conservatively by serial observation.
  • MAIN OUTCOME MEASURE(S): Tumor growth, defined as a 1 mm/year or greater increase in tumor size.
  • RESULTS: We observed that tumor growth was the most important predictor of a change in treatment strategy from serial observation to microsurgical or radiosurgical treatment.
  • We further noted in multivariate analyses that larger tumor size at diagnosis was associated with higher odds of tumor growth, such that each 1-mm increment in tumor size at presentation increased the odds of growth by 20%.
  • We also found that the symptom marker of tinnitus at diagnosis significantly increased the odds of tumor growth nearly 3-fold.
  • CONCLUSION: Tumor growth plays a significant role in guiding the management of vestibular schwannomas.
  • Assessment of tumor size at diagnosis and for the presence of tinnitus may allow for risk stratification of patients with newly diagnosed vestibular schwannomas and for a more rational application of the conservative management approach.
  • [MeSH-major] Ear Neoplasms / pathology. Neuroma, Acoustic / pathology

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  • (PMID = 20502379.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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83. Yang I, Aranda D, Han SJ, Chennupati S, Sughrue ME, Cheung SW, Pitts LH, Parsa AT: Hearing preservation after stereotactic radiosurgery for vestibular schwannoma: a systematic review. J Clin Neurosci; 2009 Jun;16(6):742-7
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  • [Title] Hearing preservation after stereotactic radiosurgery for vestibular schwannoma: a systematic review.
  • Radiosurgery has evolved into an effective alternative to microsurgical resection in the treatment of patients with vestibular schwannoma.
  • We performed a systematic analysis of the literature in English on the radiosurgical treatment of vestibular schwannoma patients.
  • A total of 254 published studies reported assessable and quantifiable outcome data of patients undergoing radiosurgery for vestibular schwannomas.
  • [MeSH-major] Hearing Loss / prevention & control. Neuroma, Acoustic / surgery. Postoperative Complications / prevention & control. Radiosurgery / adverse effects. Radiosurgery / methods
  • [MeSH-minor] Age Factors. Aged. Cochlear Nerve / physiopathology. Cochlear Nerve / radiation effects. Dose-Response Relationship, Radiation. Humans. Iatrogenic Disease / prevention & control. Middle Aged. Vestibular Nerve / pathology. Vestibular Nerve / physiopathology. Vestibular Nerve / surgery

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  • (PMID = 19303780.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Scotland
  • [Number-of-references] 113
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84. Yong RL, Westerberg BD, Dong C, Akagami R: Length of tumor-cochlear nerve contact and hearing outcome after surgery for vestibular schwannoma. J Neurosurg; 2008 Jan;108(1):105-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Length of tumor-cochlear nerve contact and hearing outcome after surgery for vestibular schwannoma.
  • OBJECTIVES: Tumor size is likely to be a major determinant of hearing preservation after surgery for vestibular schwannoma.
  • Findings in some large case series have not supported this concept, possibly due to variation in the technique used for tumor measurement.
  • The authors sought to determine if the length of tumor-cochlear nerve contact was predictive of hearing outcome in adults undergoing resection of a vestibular schwannoma.
  • METHODS: Patients who underwent a hearing-preserving approach for resection of a vestibular schwannoma at one institution by a neurosurgeon/neurotologist team between 2001 and 2005 were screened.
  • Magnetic resonance images were reviewed and used to calculate the length of tumor-cochlear nerve contact.
  • Tumors were also measured according to AAO-HNS guidelines.
  • Univariate analysis revealed that extracanalicular length of tumor-cochlear nerve contact (p = 0.0365), preoperative hearing class (p = 0.028), I-V interpeak latency of the brainstem auditory evoked potential (p = 0.021), and the interaural I-V interpeak latency difference (p = 0.018) were predictive of hearing outcome.
  • CONCLUSIONS: Vestibular schwannomas with greater lengths of tumor-cochlear nerve contact increase a patient's risk for hearing loss after surgery with attempted hearing preservation.
  • Data from the experience of a single surgical team can be used to estimate the probability of good hearing outcome for any given patient with serviceable hearing and a vestibular schwannoma.
  • [MeSH-major] Cochlear Nerve / pathology. Cochlear Nerve / surgery. Hearing Loss / etiology. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery

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  • (PMID = 18173318.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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85. Yang I, Sughrue ME, Han SJ, Fang S, Aranda D, Cheung SW, Pitts LH, Parsa AT: Facial nerve preservation after vestibular schwannoma Gamma Knife radiosurgery. J Neurooncol; 2009 May;93(1):41-8
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  • [Title] Facial nerve preservation after vestibular schwannoma Gamma Knife radiosurgery.
  • OBJECTIVE: Facial nerve preservation is a critical measure of clinical outcome after vestibular schwannoma treatment.
  • Gamma Knife radiosurgery has evolved into a practical treatment modality for vestibular schwannoma patients, with several reported series from a variety of centers.
  • In this study, we report the results of an objective analysis of reported facial nerve outcomes after the treatment of vestibular schwannomas with Gamma Knife radiosurgery.
  • MATERIALS AND METHODS: A Boolean Pub Med search of the English language literature revealed a total of 23 published studies reporting assessable and quantifiable outcome data regarding facial nerve function in 2,204 patients who were treated with Gamma Knife radiosurgery for vestibular schwannoma.
  • (1) Facial nerve preservation rates were reported specifically for vestibular schwannoma, (2) Facial nerve functional outcome was reported using the House-Brackmann classification (HBC) for facial nerve function, (3) Tumor size was documented, and (4) Gamma Knife radiosurgery was the only radiosurgical modality used in the report.
  • The data were then aggregated and analyzed based on radiation doses delivered, tumor volume, and patient age.
  • RESULTS: An overall facial nerve preservation rate of 96.2% was found after Gamma Knife radiosurgery for vestibular schwannoma in our analysis.
  • Patients receiving less than or equal to 13 Gy of radiation at the marginal dose had a better facial nerve preservation rate than those who received higher doses (<or=13 Gy = 98.5% vs. >13 Gy = 94.7%, P < 0.0001).
  • Patients with a tumor volume less than or equal to 1.5 cm(3) also had a greater facial nerve preservation rate than patients with tumors greater than 1.5 cm(3) (<or=1.5 cm(3) 99.5% vs. >1.5 cm(3) 95.5%, P < 0.0001).
  • Superior facial nerve preservation was also noted in patients younger than or equal to 60 years of age (96.8 vs. 89.4%, P < 0.0001).
  • CONCLUSION: Our analysis of case series data aggregated from multiple centers suggests that a facial nerve preservation rate of 96.2% can be expected after Gamma knife radiosurgery for vestibular schwannoma.
  • Younger patients with smaller tumors less than 1.5 cm(3) and treated with lower doses of radiation less than 13 Gy will likely have better facial nerve preservation rates after Gamma Knife radiosurgery for vestibular schwannoma.
  • [MeSH-major] Facial Nerve / radiation effects. Facial Nerve Injuries / epidemiology. Facial Nerve Injuries / etiology. Neuroma, Acoustic / surgery. Radiosurgery / adverse effects

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  • (PMID = 19430881.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 85
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86. Bush ML, Jones RO, Shinn JB: Auditory brainstem response threshold differences in patients with vestibular schwannoma: a new diagnostic index. Ear Nose Throat J; 2008 Aug;87(8):458-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Auditory brainstem response threshold differences in patients with vestibular schwannoma: a new diagnostic index.
  • Auditory brainstem response (ABR) testing is less sensitive in detecting small vestibular schwannomas than medium-size tumors.
  • Magnetic resonance imaging (MRI) is more sensitive than ABR alone for small and large tumors, but it carries with it increased cost and issues of unavailability and patient discomfort.
  • We conducted a prospective pilot study of 7 patients with untreated MRI-proven, unilateral vestibular schwannoma to determine if we could increase the sensitivity of ABR testing in detecting small tumors.
  • [MeSH-major] Brain Stem / pathology. Evoked Potentials, Auditory, Brain Stem. Neuroma, Acoustic / diagnosis

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  • (PMID = 18712694.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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87. Dalgorf DM, Rowsell C, Bilbao JM, Chen JM: Immunohistochemical investigation of hormone receptors and vascular endothelial growth factor concentration in vestibular schwannoma. Skull Base; 2008 Nov;18(6):377-84

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical investigation of hormone receptors and vascular endothelial growth factor concentration in vestibular schwannoma.
  • OBJECTIVES: To determine if a relationship exists between the presence of estrogen receptors (ER), progesterone receptors (PR), or vascular endothelial growth factor (VEGF) and the size, growth rate, and behavior of vestibular schwannoma tumors.
  • DESIGN: Nine tumor samples from young female patients with large vestibular schwannoma tumors were preselected because they were presumed to be faster growing, more aggressive tumors.
  • RESULTS: The mean age of the study sample was 32.3 years, mean tumor size was 3.2 cm, and the average growth rate was 0.4 cm per 2 months.
  • Eight of nine tumor samples stained positive for VEGF, with five demonstrating low intensity and three demonstrating moderate intensity staining.
  • CONCLUSIONS: There is histopathological evidence for the expression of VEGF in vestibular schwannomas but not for ER and PR.
  • Further studies are necessary to determine the role of VEGF and other molecular pathways in the growth of vestibular schwannomas and the application of anti-VEGF therapy as a potential treatment option in the future.

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  • (PMID = 19412407.001).
  • [ISSN] 1531-5010
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2637072
  • [Keywords] NOTNLM ; Vestibular schwannoma / acoustic neuroma / estrogen receptor / immunohistochemistry / progesterone receptor / vascular endothelial growth factor
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88. Lee CC, Yen YS, Pan DH, Chung WY, Wu HM, Guo WY, Chen MT, Liu KD, Shih YH: Delayed microsurgery for vestibular schwannoma after gamma knife radiosurgery. J Neurooncol; 2010 Jun;98(2):203-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Delayed microsurgery for vestibular schwannoma after gamma knife radiosurgery.
  • Stereotactic radiosurgery for vestibular schwannomas (VSs) has become popular during the last decade with promising clinical results after long-term follow-up.
  • However, on rare occasions, some cases have needed traditional microsurgery to remove the tumor several months or years after radiosurgery.
  • The mean size of the tumor during GKS was 10.4 ml (range 2.3-23.5 ml).
  • The indications of microsurgery included adverse radiation effect with peri-focal edema, tumor enlargement, and cyst enlargement.
  • Although the perifocal edema could lead to more difficulty in surgery than in typically performed operations for schwannoma, subtotal resection was achieved in all patients.
  • The histology showed benign tumor in five patients, malignant peripheral nerve sheath tumor in one, and necrotic tissue in one.
  • [MeSH-major] Microsurgery / methods. Neuroma, Acoustic / surgery. Postoperative Complications / etiology. Postoperative Complications / surgery. Radiosurgery / adverse effects

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  • (PMID = 20405307.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / S100 Proteins
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89. Mann W, Gouveris HT: Diagnosis and therapy of vestibular schwannoma. Expert Rev Neurother; 2009 Aug;9(8):1219-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnosis and therapy of vestibular schwannoma.
  • MRI studies are of paramount importance for diagnosis and follow-up measurements during conservative and postinterventional management of vestibular schwannomas (VS).
  • MRI findings that convey important information for hearing-preservation VS surgery are: length of tumor-cochlear nerve contact, involvement of the internal auditory canal, incomplete filling of internal auditory canal, tumor size less than 15 mm and the intralabyrinthine signal intensity on 3DFT-CISS gradient-echo images.
  • Functional neuro-otologic studies of facial nerve function, hearing and vestibular/balance function provide a valuable means of assessment of the actual impairment of the functional status of the VS patient.
  • Intraoperative monitoring of facial nerve function and hearing has been refined, resulting in improved final postoperative facial nerve and hearing outcomes in VS patients treated with microsurgery.
  • Physical rehabilitation programs are applied to accelerate vestibular functional recovery postoperatively and there is weak evidence that early physical rehabilitation may improve the final facial nerve outcome.
  • [MeSH-major] Cochlear Nerve. Neuroma, Acoustic / diagnosis. Neuroma, Acoustic / therapy

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  • (PMID = 19673609.001).
  • [ISSN] 1744-8360
  • [Journal-full-title] Expert review of neurotherapeutics
  • [ISO-abbreviation] Expert Rev Neurother
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 116
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90. Shiobara R, Ohira T, Inoue Y, Kanzaki J, Kawase T: Extended middle cranial fossa approach for vestibular schwannoma: technical note and surgical results of 896 operations. Prog Neurol Surg; 2008;21:65-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extended middle cranial fossa approach for vestibular schwannoma: technical note and surgical results of 896 operations.
  • From 1976 to 2006, 896 vestibular schwannomas were operated on using an extended middle cranial fossa approach.
  • With this approach, the operative field can be extended according to tumor size and the facial and cochlear nerves can be preserved more easily with cooperation between the neurosurgeon and ENT surgeon.
  • The mortality rate among 896 vestibular schwannoma patients was 0.3%.
  • In the 760 initially operated vestibular schwannomas with total removal of the tumor, facial nerves were anatomically preserved in 715 or 94.1% of the cases.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Cerebellopontine Angle. Cranial Fossa, Middle / surgery. Neuroma, Acoustic / surgery. Neurosurgical Procedures / methods

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  • (PMID = 18810200.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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91. Linskey ME: Hearing preservation in vestibular schwannoma stereotactic radiosurgery: what really matters? J Neurosurg; 2008 Dec;109 Suppl:129-36
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hearing preservation in vestibular schwannoma stereotactic radiosurgery: what really matters?
  • Stereotactic radiosurgery (SRS) for vestibular schwannomas has evolved and improved over time.
  • Although early short-term follow-up reports suggest that fractionation yields hearing preservation rates equivalent to modern single-dose SRS techniques, significant questions remain regarding long-term tumor control after the use of fractionation in a late responding tumor with a low proliferative index and alpha/beta ratio.
  • 2) careful delineation of the 3D tumor margin to exclude the cochlear nerve when visualizable with contrast-enhanced T2-weighted MR volumetric imaging techniques and exclusion the dura mater of the anterior border of the internal auditory canal;.
  • 3) a tumor margin dose prescription <or= 12 Gy;.
  • 4) optimization of the tumor treatment gradient index without sacrificing coverage and conformality; and 5) strict attention to prescription dose 3D conformality so that the modiolus and the basal turn of the cochlea receive the lowest possible dose (ideally < 4-5.33 Gy).
  • [MeSH-major] Hearing Loss / prevention & control. Neuroma, Acoustic / surgery. Radiosurgery
  • [MeSH-minor] Ear, Inner / pathology. Humans. Neoplasm Invasiveness. Radiotherapy Dosage. Tumor Burden

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  • (PMID = 19123899.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 38
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92. Mackle T, Rawluk D, Walsh RM: Atypical clinical presentations of vestibular schwannomas. Otol Neurotol; 2007 Jun;28(4):526-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical clinical presentations of vestibular schwannomas.
  • A significant number of patients with vestibular schwannomas present atypically, with none of the classical symptoms of unilateral sensorineural hearing loss, tinnitus, and/or dysequilibrium.
  • STUDY DESIGN: The clinical data of all patients who presented to the vestibular schwannoma clinic at Beaumont Hospital over the past 12 years was prospectively recorded in a computerized database.
  • CONCLUSION: A significant subgroup, 3.7% in our study, did not present with the audiovestibular symptoms classically associated with vestibular schwannoma.
  • [MeSH-major] Neuroma, Acoustic / diagnosis

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  • (PMID = 17414179.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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93. Bouetel V, Lescanne E, François P, Jan M, Morinière S, Robier A: [Evolution of facial nerve prognosis in vestibular schwannoma surgery by translabyrinthine approach]. Rev Laryngol Otol Rhinol (Bord); 2008;129(1):27-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Evolution of facial nerve prognosis in vestibular schwannoma surgery by translabyrinthine approach].
  • [Transliterated title] Evolution du pronostic du nerf facial dans la chirurgie du neurinome de l'acoustique par voie translabyrinthique.
  • PATIENTS AND METHODS: A series of 248 patients operated of an unilateral vestibular schwannoma has been reviewed.
  • The other factors are the hearing level, deafness duration, trigeminal nerve involved, vestibular status and ABR desynchronization.
  • CONCLUSION: The positive predictive factors are usually correlated with the size of the tumour This implies the necessity of an early diagnosis of the schwannomas.
  • [MeSH-major] Ear Neoplasms / surgery. Ear, Inner / surgery. Facial Nerve / physiology. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Evoked Potentials, Auditory, Brain Stem / physiology. Facial Nerve Diseases / diagnosis. Facial Nerve Diseases / physiopathology. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Prospective Studies. Severity of Illness Index

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  • (PMID = 18777766.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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94. Al Sanosi A, Fagan PA, Biggs ND: Conservative management of acoustic neuroma. Skull Base; 2006 May;16(2):95-100

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conservative management of acoustic neuroma.
  • AIM OF STUDY: To identify those patients with vestibular schwannoma (acoustic neuroma) in whom treatment becomes necessary.
  • RESULT: A total of 205 patients with small tumors were followed for a mean of 40.8 months.
  • In 136 patients (66.3%) the tumor did not grow.
  • Eight of 197 patients (4%) had rapid growth and 6 patients (3%) had radiological evidence of tumor regression.
  • Five of these showed rapid growth, four developed ataxia in whom tumor growth was slow, three had ataxia without tumor growth, two patients developed brainstem compression, and one patient elected to proceed to surgery, although there were no tumor growth or symptoms.
  • CONCLUSION: Few patients with small tumors will come to surgery in the short term.
  • Perhaps the majority of patients with such small tumors will not need surgery.
  • Long-term follow-up studies of 20 years or more are required to be come more confident about the natural history of these tumors.

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  • (PMID = 17077873.001).
  • [ISSN] 1531-5010
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1502035
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95. Nagano O, Higuchi Y, Serizawa T, Ono J, Matsuda S, Yamakami I, Saeki N: Transient expansion of vestibular schwannoma following stereotactic radiosurgery. J Neurosurg; 2008 Nov;109(5):811-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transient expansion of vestibular schwannoma following stereotactic radiosurgery.
  • OBJECT: The authors prospectively analyzed volume changes in vestibular schwannomas (VSs) after stereotactic radiosurgery.
  • The frequency and degree of transient tumor expansion were documented and possible prognostic factors were analyzed.
  • Concurrently, neurological deterioration involving trigeminal, facial, and cochlear nerve functions were also assessed.
  • Tumor volumes at GKS averaged 2.7 cm3 (range 0.1-13.2 cm3), and the lesions were irradiated at the mean 52.2% isodose line for the tumor margin (range 50-67%), with a mean dose of 12.2 Gy (range 10.5-13 Gy) at the periphery.
  • The tumor volume was increased by 23% at 3 months and 27% at 6 months.
  • Tumors shrank to their initial size over a mean period of 12 months.
  • The peak tumor expansion averaged 47% (range 0-613%).
  • A high-dose (> or = 3.5 Gy/min) treatment appears to be the greatest risk factor for transient tumor expansion, although the difference did not reach statistical significance.
  • Transient facial palsy and facial dysesthesia correlated strongly with tumor expansion, but only half of the hearing loss was coincident with this phenomenon.
  • CONCLUSIONS: Transient expansion of VSs after GKS was found to be much more frequent than previously reported, strongly suggesting a correlation with deterioration of facial and trigeminal nerve functions.
  • [MeSH-major] Ear Neoplasms / surgery. Neuroma, Acoustic / surgery. Radiosurgery / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cranial Nerves / physiopathology. Facial Nerve / physiopathology. Female. Humans. Male. Middle Aged. Prospective Studies. Risk Factors. Treatment Outcome. Trigeminal Nerve / physiopathology. Tumor Burden

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  • (PMID = 18976069.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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96. Luppino FS, Grooters E, de Bruïne FT, Zwinderman AH, van der Mey AG: Volumetrical measurements in vestibular schwannoma, the influence of slice thickness and patient's repositioning. Otol Neurotol; 2006 Oct;27(7):962-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Volumetrical measurements in vestibular schwannoma, the influence of slice thickness and patient's repositioning.
  • OBJECTIVE: Conservative treatment in vestibular schwannomas is mainly dependent on optimal tumor size determination.
  • Because of a relatively large systematic error in small tumors, sensitivity of growth detection is low.
  • CONCLUSION: The volumetrical gray shade method is the most accurate method to detect early tumor progression.
  • As tumor increase of at least 50% is needed to be able to speak of statistically significant tumor growth, the absence of radiologic progression does not mean that there is no tumor growth.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Neuroma, Acoustic / pathology. Observer Variation

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  • (PMID = 17006347.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Validation Studies
  • [Publication-country] United States
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97. Lloyd SK, Kasbekar AV, Baguley DM, Moffat DA: Audiovestibular factors influencing quality of life in patients with conservatively managed sporadic vestibular schwannoma. Otol Neurotol; 2010 Aug;31(6):968-76
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Audiovestibular factors influencing quality of life in patients with conservatively managed sporadic vestibular schwannoma.
  • OBJECTIVES: To measure the health-related quality of life (QoL) of patients undergoing conservative management of a vestibular schwannoma and to identify audiovestibular factors that influence health-related QoL.
  • INTERVENTION: Adult patients undergoing conservative management of a sporadic vestibular schwannoma were identified from a prospectively updated database.
  • CONCLUSION: Dizziness is the most significant audiovestibular predictor of QoL in patients with vestibular schwannomas.
  • [MeSH-major] Hearing Loss / etiology. Hearing Loss / psychology. Neuroma, Acoustic / psychology. Neuroma, Acoustic / therapy. Quality of Life. Vestibular Diseases / etiology. Vestibular Diseases / psychology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Audiometry, Pure-Tone. Case-Control Studies. Cohort Studies. Cross-Sectional Studies. Disability Evaluation. Dizziness / etiology. Female. Humans. Male. Mental Health. Middle Aged. Prospective Studies. Social Behavior. Surveys and Questionnaires. Tinnitus / etiology. Vestibular Function Tests

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  • (PMID = 20684063.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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98. Yates CW, Weinberg M, Packer MJ, Jacob A: Fatal case of tumor-associated hemorrhage in a large vestibular schwannoma. Ann Otol Rhinol Laryngol; 2010 Jun;119(6):402-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fatal case of tumor-associated hemorrhage in a large vestibular schwannoma.
  • Vestibular schwannomas are benign neoplasms that arise from Schwann cells of the eighth cranial nerve.
  • Most manifest clinically with tinnitus, unilateral sensorineural hearing loss, and dysequilibrium secondary to compression of the vestibulocochlear nerve; major adverse events such as intratumoral hemorrhage causing acute neurologic deterioration are rare.
  • We report the case of a 69-year-old man with a large vestibular schwannoma who required anticoagulation for several medical comorbidities.
  • The patient began having progressively worsening neurologic symptoms, including facial nerve paralysis and dysequilibrium, which confined him to a wheelchair.
  • Several days after alteration of his anticoagulation therapy in preparation for surgery, he developed intracranial hemorrhage.
  • Attempts were made to stabilize the patient, including posterior fossa craniectomy and evacuation of hematoma; however, the intracranial hemorrhage ultimately resulted in a fatal outcome.
  • During this procedure, a biopsy specimen was obtained, showing benign vestibular schwannoma.
  • The literature for intratumoral hemorrhage into vestibular schwannoma and the pathologic findings in our case are reviewed.
  • [MeSH-major] Intracranial Hemorrhages / etiology. Neuroma, Acoustic / complications
  • [MeSH-minor] Aged. Anticoagulants / therapeutic use. Comorbidity. Disease Progression. Fatal Outcome. Heart Valve Prosthesis. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Retrospective Studies. Warfarin / therapeutic use

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  • (PMID = 20583739.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticoagulants; 5Q7ZVV76EI / Warfarin
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99. Kania RE, Herman P, Guichard JP, Tran Ba Huy P: [Dilation of the internal auditory canal and intracanalicular vestibular schwannoma: what are the mechanisms involved?]. Ann Otolaryngol Chir Cervicofac; 2008 Nov;125(5):256-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Dilation of the internal auditory canal and intracanalicular vestibular schwannoma: what are the mechanisms involved?].
  • [Transliterated title] Dilatation du méat acoustique interne et schwannome vestibulaire intracanalaire: quels mécanismes?
  • OBJECTIVES: To present a unique case of unilateral widening of the internal auditory canal (IAC) with no significant contact with an ipsilateral intracanalicular vestibular schwannoma (VS), raising the issue of the cause(s) of this IAC widening.
  • [MeSH-major] Ear Diseases / etiology. Ear, Inner / pathology. Neuroma, Acoustic / complications

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  • (PMID = 18786666.001).
  • [ISSN] 0003-438X
  • [Journal-full-title] Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris
  • [ISO-abbreviation] Ann Otolaryngol Chir Cervicofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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100. Godefroy WP, Kaptein AA, Vogel JJ, van der Mey AG: Conservative treatment of vestibular schwannoma: a follow-up study on clinical and quality-of-life outcome. Otol Neurotol; 2009 Oct;30(7):968-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conservative treatment of vestibular schwannoma: a follow-up study on clinical and quality-of-life outcome.
  • OBJECTIVE: To determine the natural history and long-term quality-of-life (QOL) outcome after conservative treatment for vestibular schwannoma.
  • PATIENTS: A total of 70 vestibular schwannoma patients who were initially included in the wait and scan protocol between January 2002 and December 2003 were followed with a mean observation time of 43 months.
  • All patients had small- or medium-sized tumors when they were included in the protocol.
  • The study group was characterized by nongrowing small tumors and relatively stable symptoms over time.
  • RESULTS: In 44 patients (63%), growth of the tumor was not observed, and 25 (36%) tumors did grow.
  • CONCLUSION: Conservative observation of small vestibular schwannomas may be regarded as a reasonable management option because most of these tumors do not grow during an initial period of observation.
  • Conservative treatment of this subset of patients with small, nongrowing tumors does not significantly affect life functioning, as reflected in SF-36 survey data.
  • This study emphasizes the importance of combining generic and disease-specific QOL measures in future studies of protocols of vestibular schwannoma management.
  • [MeSH-major] Neuroma, Acoustic / therapy. Quality of Life

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  • (PMID = 19730147.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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