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1. Grant EA, Trzupek KM, Reiss J, Crow K, Messiaen L, Weleber RG: Combined retinal hamartomas leading to the diagnosis of neurofibromatosis type 2. Ophthalmic Genet; 2008 Sep;29(3):133-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Patient one presented to ophthalmology at the age of 2 years; by 4 years, he developed what was thought to be a plexiform neurofibroma and, with more than 6 cafe au lait spots, was diagnosed with neurofibromatosis type 1 (NF1).
  • By the age of 5, he had developed bilateral vestibular schwannomas, and was diagnosed with NF2.
  • Despite lack of pathological evidence of neurofibroma upon biopsy, molecular testing was initiated at age 6 and revealed a truncating mutation in exon 8 (c.734delA) of the NF2 gene in the blood.
  • The recognition of this rare finding as a presenting feature of NF2 can lead to earlier diagnosis, which is vital to appropriate surveillance and possible surgical intervention.

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  • (PMID = 18766994.001).
  • [ISSN] 1744-5094
  • [Journal-full-title] Ophthalmic genetics
  • [ISO-abbreviation] Ophthalmic Genet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Codon, Nonsense
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2. Bayazit YA, Celenk F, Duzlu M, Goksu N: Management of cerebrospinal fluid leak following retrosigmoid posterior cranial fossa surgery. ORL J Otorhinolaryngol Relat Spec; 2009;71(6):329-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The CSF leaks were documented in 22 of the vestibular schwannoma surgeries (68.7%) and 10 of the vestibular nerve sectioning surgeries (31.3%).
  • No CSF leak was seen following microvascular decompression and auditory brain stem implantation surgeries.
  • [MeSH-major] Cerebrospinal Fluid Rhinorrhea / surgery. Cerebrospinal Fluid Rhinorrhea / therapy. Cranial Fossa, Posterior / surgery. Drainage / methods. Neuroma, Acoustic / surgery

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 20068375.001).
  • [ISSN] 1423-0275
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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3. Yang SY, Kim DG, Chung HT, Park SH, Paek SH, Jung HW: Evaluation of tumour response after gamma knife radiosurgery for residual vestibular schwannomas based on MRI morphological features. J Neurol Neurosurg Psychiatry; 2008 Apr;79(4):431-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of tumour response after gamma knife radiosurgery for residual vestibular schwannomas based on MRI morphological features.
  • OBJECTIVE: To evaluate tumour response after gamma knife (GK) radiosurgery for residual vestibular schwannoma (VS) based on MRI morphological features.
  • RESULTS: Median duration of radiological follow-up was 53.7 months (range, 24.1-102.2) and the 8-year actuarial tumour control rate was 93.5%.
  • [MeSH-major] Magnetic Resonance Imaging. Neoplasm, Residual / surgery. Neuroma, Acoustic / surgery. Radiosurgery
  • [MeSH-minor] Actuarial Analysis. Adolescent. Adult. Aged. Brain / pathology. Female. Follow-Up Studies. Half-Life. Humans. Male. Microsurgery. Middle Aged. Necrosis. Reoperation. Tumor Burden

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  • (PMID = 17673492.001).
  • [ISSN] 1468-330X
  • [Journal-full-title] Journal of neurology, neurosurgery, and psychiatry
  • [ISO-abbreviation] J. Neurol. Neurosurg. Psychiatry
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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4. Kameda K, Shono T, Hashiguchi K, Yoshida F, Sasaki T: Effect of tumor removal on tinnitus in patients with vestibular schwannoma. J Neurosurg; 2010 Jan;112(1):152-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of tumor removal on tinnitus in patients with vestibular schwannoma.
  • OBJECT: Tinnitus is one of the most common symptoms in patients with vestibular schwannomas (VSs), but the effect of surgery on this symptom has not been fully evaluated.
  • The aim of this study was to define the effect on tinnitus of tumor removal, cochlear nerve resection, and useful hearing preservation in patients with VSs.
  • RESULTS: Of 242 patients, 171 (70.7%) complained of tinnitus before surgery; the symptom disappeared in 25.2%, improved in 33.3%, remained unchanged in 31.6%, and worsened in 9.9% of these cases after tumor removal.
  • In the 171 patients with preoperative tinnitus, the cochlear nerve was resected in 85 (49.7%) and preserved in 86 (50.3%), but there was no significant difference in the incidence of postoperative tinnitus between these 2 groups (p = 0.293).
  • Among those without preoperative tinnitus, the cochlear nerve was resected in 45 cases (63.4%) and tinnitus appeared postoperatively in 3 (6.7%).
  • CONCLUSIONS: Tumor removal via the retrosigmoid lateral suboccipital approach may provide some chance for improvement of tinnitus in patients with VSs; however, neither cochlear nerve resection nor useful hearing preservation affects the postoperative development of tinnitus.
  • [MeSH-major] Neuroma, Acoustic / complications. Neuroma, Acoustic / surgery. Tinnitus / etiology. Tinnitus / surgery
  • [MeSH-minor] Cochlear Nerve / surgery. Female. Hearing Disorders / etiology. Humans. Male. Middle Aged. Retrospective Studies. Severity of Illness Index. Treatment Outcome


5. Hasegawa T, Fujitani S, Katsumata S, Kida Y, Yoshimoto M, Koike J: Stereotactic radiosurgery for vestibular schwannomas: analysis of 317 patients followed more than 5 years. Neurosurgery; 2005 Aug;57(2):257-65; discussion 257-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Stereotactic radiosurgery for vestibular schwannomas: analysis of 317 patients followed more than 5 years.
  • OBJECTIVE: Many investigators have reported successful treatment of vestibular schwannomas with gamma knife radiosurgery (GKRS).
  • However, long-term outcomes should be evaluated before concluding that GKRS is truly safe and effective for the treatment of vestibular schwannomas.
  • Of 301 patients who underwent serial follow-up imaging, two (1%) experienced complete remission, 184 (61%) experienced partial remission, 93 (31%) had stable tumors, and 22 (7%) experienced treatment failure.
  • Tumors less than 15 cm3 in volume (10-yr PFS, 96%; P < 0.001) or which did not compress the brainstem and deviate the fourth ventricle (10-yr PFS, 97%; P = 0.008) resulted in significantly better PFS rates.
  • When the tumor was treated with a marginal dose of 13 Gy or less, the hearing preservation rate was 68%, transient facial palsy developed at a rate of 1%, and facial numbness developed at a rate of 2%.
  • CONCLUSION: GKRS proved to be a safe and effective treatment for patients followed longer than 5 years who presented with tumors with a volume of less than 15 cm3 and who did not have significant fourth ventricle deviation.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Neuroma, Acoustic / surgery. Radiosurgery / methods. Treatment Outcome

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  • (PMID = 16094154.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] United States
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6. Tlachacova D, Schmitt M, Novotny J Jr, Novotny J, Majali M, Liscak R: A comparison of the gamma knife model C and the Automatic Positioning System with Leksell model B. J Neurosurg; 2005 Jan;102(s_supplement):25-28
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Data were analyzed in patients in whom the following diagnoses had been made: vestibular schwannoma, pituitary adenoma, meningioma, solitary metastasis, and other benign and malignant solitary tumors.
  • CONCLUSIONS: With the C model there was a better conformity for most treated targets, such as vestibular schwannomas (p = 0.005) and meningiomas (p = 0.015).

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  • (PMID = 28306471.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; conformity index / extracranial exposure / staff exposure / stereotactic radiosurgery
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7. Roos DE, Brophy BP, Bhat MK, Katsilis ES: Update of radiosurgery at the Royal Adelaide Hospital. Australas Radiol; 2006 Apr;50(2):158-67
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This is an update of the Royal Adelaide Hospital radiosurgery experience between November 1993 and December 2004 comprising 165 patients with 168 intracranial lesions.
  • The commonest lesions were acoustic neuroma (65), arteriovenous malformation (58), solitary brain metastasis (23) and meningioma (14).
  • Radiosurgery provides an elegant, non-invasive alternative to neurosurgery and conventional external beam radiotherapy for many benign and malignant brain tumours.
  • [MeSH-major] Brain Neoplasms / surgery. Hospitals / utilization. Lung Neoplasms / secondary. Meningeal Neoplasms / surgery. Meningioma / surgery. Neuroma, Acoustic / surgery. Outcome Assessment (Health Care) / statistics & numerical data. Radiosurgery / methods. Utilization Review
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Brain / pathology. Brain / radiography. Brain / surgery. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Intracranial Arteriovenous Malformations / surgery. Male. Middle Aged. Prospective Studies. South Australia. Survival Analysis


8. Parhizkar N, Hiltzik DH, Selesnick SH: Facial nerve rerouting in skull base surgery. Otolaryngol Clin North Am; 2005 Aug;38(4):685-710, ix
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Facial nerve rerouting in skull base surgery.
  • Facial nerve rerouting techniques were developed to facilitate re-section of extensive tumors occupying the skull base.
  • Facial nerve rerouting has its own limitations and risks, requiring microsurgical expertise, additional surgical time, and often some degree of facial nerve paresis.
  • This article presents different degrees of anterior and posterior facial nerve rerouting, techniques of facial nerve rerouting, and a comprehensive review of outcomes.
  • It then reviews anatomic and functional preservation of the facial nerve in acoustic neuroma resection, technical aspects of facial nerve dissection, intracranial facial nerve repair options, and outcomes for successful acoustic neuroma surgery.
  • [MeSH-major] Facial Nerve / surgery. Skull Base Neoplasms / surgery
  • [MeSH-minor] Cranial Fossa, Middle / surgery. Dissection. Glomus Jugulare Tumor / surgery. Glomus Tumor / surgery. Humans. Meningeal Neoplasms / surgery. Meningioma / surgery. Neuroma, Acoustic / surgery

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  • (PMID = 16005726.001).
  • [ISSN] 0030-6665
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 79
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9. Kutz JW, Barnett SL, Hatanpaa KJ, Mendelsohn DB: Concurrent vestibular schwannoma and meningioma mimicking a single cerebellopontine angle tumor. Skull Base; 2009 Nov;19(6):443-6
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  • [Title] Concurrent vestibular schwannoma and meningioma mimicking a single cerebellopontine angle tumor.
  • Vestibular schwannomas account for ~;80% of cerebellopontine angle (CPA) tumors, with meningiomas being the second most common tumor of the CPA.
  • The occurrence of both a schwannoma and a meningioma in the cerebellopontine angle is rare.
  • After obtaining Institutional Review Board approval, we present a case of a concurrent vestibular schwannoma and meningioma in the CPA mimicking a single tumor.

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  • [Cites] Neurosurgery. 1992 Mar;30(3):443-5; discussion 445-6 [1620314.001]
  • [Cites] Clin Neuropathol. 2007 Sep-Oct;26(5):219-23 [17907598.001]
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  • (PMID = 20436847.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2793893
  • [Keywords] NOTNLM ; Acoustic neuroma / cerebellopontine angle / meningioma / vestibular schwannoma
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10. Hastan D, Godefroy WP, Malessy MJ, van der Mey AG: Establishing a method to predict the outcome of vestibular schwannoma surgery based on one's own results. Clin Otolaryngol; 2007 Oct;32(5):346-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Establishing a method to predict the outcome of vestibular schwannoma surgery based on one's own results.
  • OBJECTIVES: To establish a prognostication method based on our own results of vestibular schwannoma surgery.
  • PARTICIPANTS: 141 ambulatory patients operated for unilateral vestibular schwannoma by the translabyrinthine approach in the period 1996--2003.
  • MAIN OUTCOME MEASURES: Facial impairment defined by House Brackmann grade III-VI, and the relation with tumor size.
  • RESULTS: For our institution we found that in a range of tumor sizes the tumor size of 17.5 mm was the cut-off point associated with highest sensitivity and specificity values available concerning the prediction of facial impairment, these were 0.86 and 0.61.
  • In vestibular schwannoma surgery this leads to more precise predictions concerning outcome, as we have demonstrated for the facial function.
  • [MeSH-major] Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods

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  • (PMID = 17883553.001).
  • [ISSN] 1749-4478
  • [Journal-full-title] Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • [ISO-abbreviation] Clin Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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11. Skrivan J, Betka J, Zverina E, Vrabec P, Chovanec M, Borský I: Complicated decisionmaking in indications for auditory brainstem implant (ABI) in a patient with neurofibromatosis 2. Prague Med Rep; 2007;108(3):256-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A case of an accidental finding of neurofibromatosis 2 in a practically asymptomatic patient is described.
  • Various therapeutic modalities, including restoration of hearing after vestibular schwannoma surgery with an auditory brainstem implant (ABI), are considered.
  • [MeSH-major] Auditory Brain Stem Implants. Neurofibromatosis 2 / surgery

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  • (PMID = 18399063.001).
  • [ISSN] 1214-6994
  • [Journal-full-title] Prague medical report
  • [ISO-abbreviation] Prague Med Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Czech Republic
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12. Brackmann DE, Cullen RD, Fisher LM: Facial nerve function after translabyrinthine vestibular schwannoma surgery. Otolaryngol Head Neck Surg; 2007 May;136(5):773-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Facial nerve function after translabyrinthine vestibular schwannoma surgery.
  • OBJECTIVES: To evaluate the long-term facial function of patients after translabyrinthine vestibular schwannoma [VS] surgery and identify factors that influence these outcomes.
  • Patient and tumor characteristics as well as perioperative complications are described.
  • Patients with smaller tumors have significantly better postoperative facial function than those with larger tumors.
  • [MeSH-major] Ear, Inner / surgery. Facial Nerve / physiopathology. Facial Paralysis / diagnosis. Facial Paralysis / physiopathology. Neuroma, Acoustic / surgery. Postoperative Complications / epidemiology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Craniotomy. Disease Progression. Female. Follow-Up Studies. Humans. Male. Microsurgery. Middle Aged. Prevalence. Retrospective Studies. Surveys and Questionnaires


13. Filipo R, Attanasio G, De Seta E, Viccaro M: Post-operative Herpes simplex virus encephalitis after surgical resection of acoustic neuroma: a case report. J Laryngol Otol; 2005 Jul;119(7):558-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Post-operative Herpes simplex virus encephalitis after surgical resection of acoustic neuroma: a case report.
  • The appearance of a strong headache followed by impairment of consciousness and hypertone of arms and legs complicated the post-operative course in a 33-year-old patient who underwent surgical removal of an acoustic neuroma.
  • Several brain magnetic resonance imaging (MRI) and computed tomography scans performed in the first week after onset of symptoms of infection did not establish a proper diagnosis.
  • Diffusion-weighted MRI detected brain abnormalities on the fourth day after onset of symptoms, and polymerase chain reaction identification of HSV 1 DNA confirmed the diagnosis.
  • [MeSH-major] Encephalitis, Herpes Simplex / etiology. Neuroma, Acoustic / surgery. Postoperative Complications / etiology


14. Chen L, Wu H, Huang Q, Yang J, Jia H, Zhang Z: [Defect reconstruction after removal of tumor in lateral skull base]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2009 May;23(10):433-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Defect reconstruction after removal of tumor in lateral skull base].
  • OBJECTIVE: To explore the methods of reconstruction for the defects of lateral skull base after removal of tumor.
  • METHOD: One hundred and thirty two patients who underwent removal of tumor in the lateral skull base and reconstruction of defects after surgery were summarized retrospectively.
  • They suffered from acoustic neuroma (92 cases), the tumor in the jugular foramen (21 cases), neoplasms in the infratemporal fossa (6 cases), recurrent nasopharyngeal carcinoma after radiotherapy (4 cases), cancer of middle ear (3 cases), meningioma (2 cases), arachnoid cyst in the cerebellopontine angle (2 cases), and squamous cell carcinoma of the temporal bone (2 cases).
  • The intracranial infection was not found in these patients.
  • CONCLUSION: According to the position of tumor in the lateral skull and different type of defect, different reconstructing methods and materials were used.
  • The reconstruction in the lateral skull base and infratemporal fossa defect plays an important role to eliminate dead space, and avoid leakage of cerebrospinal fluid and intracranial infection, which is one of key points in the lateral base surgery.

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  • (PMID = 19670621.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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15. Saeed SR, Suryanarayanan R, Dezso A, Ramsden RT: Vestibular schwannoma management: current practice amongst UK otolaryngologists--time for a national prospective audit. Ann R Coll Surg Engl; 2006 Sep;88(5):490-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vestibular schwannoma management: current practice amongst UK otolaryngologists--time for a national prospective audit.
  • INTRODUCTION: It is generally agreed that the successful management of a vestibular schwannoma (VS) usually involves close collaboration between a neuro-otologist and neurosurgeon.
  • [MeSH-major] Neuroma, Acoustic / surgery. Otorhinolaryngologic Surgical Procedures / standards. Professional Practice / standards

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  • [Cites] J Neurol Neurosurg Psychiatry. 2000 Aug;69(2):147-8 [10896683.001]
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  • (PMID = 17002858.001).
  • [ISSN] 1478-7083
  • [Journal-full-title] Annals of the Royal College of Surgeons of England
  • [ISO-abbreviation] Ann R Coll Surg Engl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1964657
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16. Isaacson B, Telian SA, El-Kashlan HK: Facial nerve outcomes in middle cranial fossa vs translabyrinthine approaches. Otolaryngol Head Neck Surg; 2005 Dec;133(6):906-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Facial nerve outcomes in middle cranial fossa vs translabyrinthine approaches.
  • OBJECTIVE: To compare the final facial nerve outcomes between middle cranial fossa (MCF) vs translabyrinthine (TL) resection of size-matched vestibular schwannomas.
  • All patients who underwent resection utilizing either MCF or TL approaches with tumors 18 mm or smaller and complete data were included in the analysis.
  • One-week-postoperative and final facial nerve examinations were compared in the two surgical groups.
  • Patients were separately analyzed in subgroups: tumors smaller than 10 mm and those that were between 10 and 18 mm.
  • RESULTS: The tumor size range for the MCF group was 3-18 mm while it was 4-18 mm for the TL group.
  • No statistically significant difference was found in facial nerve outcomes between the two surgical groups, at the first postoperative visit week and at last follow-up.
  • CONCLUSION: Facial nerve outcomes are similar using TL and MCF approaches for resection of vestibular schwannomas up to 18 mm in size.
  • SIGNIFICANCE: Patients undergoing the MCF approach for hearing preservation can be counseled that there is no increased risk of permanent facial nerve weakness, compared to the TL approach.
  • [MeSH-major] Cranial Fossa, Middle / surgery. Ear, Inner / surgery. Facial Nerve / physiopathology. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods

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  • (PMID = 16360512.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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17. Zverina E: [Acoustic neuroma--vestibular schwannoma--personal experience of up-to-date management]. Cas Lek Cesk; 2010;149(6):269-76
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Acoustic neuroma--vestibular schwannoma--personal experience of up-to-date management].
  • [Transliterated title] Neurinom akustiku--vestibulární schwannom--osobní pohled na nejmodernejsí postupy v jeho lécbe.
  • Acoustic neuroma, properly called vestibular schwannoma, arises from the Schwann cells of the vestibular transitional zone of the vestibulocochlear nerve as the most frequent tumour of the posterior fossa.
  • Its incidence is estimated at 1.2 vestibular schwannoma per a population of 100,000/year.
  • As to size, vestibular schwannoma is classified into grades I to IV.
  • About one third of small vestibular schwannoma show hardly any growth, the larger ones grow aggressively.
  • The author's conclusion is based on 33 years of experience with hundreds of surgically treated vestibular schwannoma (now at the ENT Department of Head and Neck Surgery, CU 1st Medical Faculty and FN Teaching Hospital, Prague Motol).
  • Irradiation for larger vestibular schwannoma is decreasingly efficacious.
  • 3. Microsurgery with intraoperative monitoring of facial and acoustic nerve function offers scope for radical removal of vestibular schwannoma of any size (grades I-IV) and for the preservation of facial nerve function and, of late, hearing, too.
  • [MeSH-major] Neuroma, Acoustic


18. Solares CA, Panizza B: Vestibular schwannoma: an understanding of growth should influence management decisions. Otol Neurotol; 2008 Sep;29(6):829-34
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  • [Title] Vestibular schwannoma: an understanding of growth should influence management decisions.
  • BACKGROUND: Treatments for vestibular schwannomas include surgical removal and radiotherapy.
  • Observation is a reasonable alternative, given the slow growth of these tumors.
  • METHODS: Patients with unilateral vestibular schwannomas who presented in the last 10 years were reviewed.
  • The following information was recorded from the charts: age, sex, tumor size at presentation and subsequent follow-up sessions, treatment in the event of growth, and time interval between presentation and last imaging available.
  • Interestingly, 11 patients (10%) demonstrated tumor regression.
  • Patients with intracanalicular tumors had a 5-year no-growth rate of 89.8% compared with 73.9% and 45.2% for Grade I and Grade II or larger tumors, respectively.
  • The difference between intracanalicular and Grade II or larger tumors was statistically significant (p = 0.0196).
  • CONCLUSION: Our data suggest that treatment can be delayed in a large proportion of vestibular schwannoma patients and that this is particularly true in patients with small tumors.
  • [MeSH-major] Ear Neoplasms / radiotherapy. Ear Neoplasms / surgery. Neuroma, Acoustic / radiotherapy. Neuroma, Acoustic / surgery

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  • (PMID = 18636034.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Croft RJ, McKenzie RJ, Inyang I, Benke GP, Anderson V, Abramson MJ: Mobile phones and brain tumours: a review of epidemiological research. Australas Phys Eng Sci Med; 2008 Dec;31(4):255-67
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  • [Title] Mobile phones and brain tumours: a review of epidemiological research.
  • There are reports of small associations between MP-use ipsilateral to the tumour for greater than 10 years, for both acoustic neuroma and glioma, but the present paper argues that these are especially prone to confounding by recall bias.

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  • (PMID = 19239052.001).
  • [ISSN] 0158-9938
  • [Journal-full-title] Australasian physical & engineering sciences in medicine
  • [ISO-abbreviation] Australas Phys Eng Sci Med
  • [Language] ENG
  • [Publication-type] Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 50
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20. Régis J, Roche PH, Delsanti C, Thomassin JM, Ouaknine M, Gabert K, Pellet W: Modern management of vestibular schwannomas. Prog Neurol Surg; 2007;20:129-41
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  • [Title] Modern management of vestibular schwannomas.
  • Within the last 3 decades, microsurgery and stereotactic radiosurgery (SRS) have become well-established management options for vestibular schwannomas (VSs).
  • A long-term tumor control rate of 97%, transient facial palsy lower than 1%, and a probability of functional hearing preservation between 50 and 95% was achieved in this large series of patients treated with state-of-the-art SRS.
  • [MeSH-major] Neuroma, Acoustic / surgery. Postoperative Complications / epidemiology. Radiosurgery

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  • (PMID = 17317981.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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21. Pollock BE: Stereotactic radiosurgery of benign intracranial tumors. J Neurooncol; 2009 May;92(3):337-43
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  • [Title] Stereotactic radiosurgery of benign intracranial tumors.
  • Stereotactic radiosurgery is a frequently performed procedure for patients with benign intracranial tumors.
  • Benign tumors are good candidates for radiosurgery because they are generally non-invasive, are well visualized by magnetic resonance imaging, and their slow rate of proliferation makes conventional radiation dose fractionation unnecessary.
  • This chapter will review the indications and results of radiosurgery for patients with intracranial meningiomas, vestibular schwannomas, and pituitary adenomas having single-fraction radiosurgery at the Mayo Clinic since 1990.
  • [MeSH-major] Adenoma / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Neuroma, Acoustic / surgery. Pituitary Neoplasms / surgery. Radiosurgery

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  • (PMID = 19357960.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 48
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22. Nagano O, Serizawa T, Higuchi Y, Matsuda S, Sato M, Yamakami I, Okiyama K, Ono J, Saeki N: Tumor shrinkage of vestibular schwannomas after Gamma Knife surgery: results after more than 5 years of follow-up. J Neurosurg; 2010 Dec;113 Suppl:122-27
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  • [Title] Tumor shrinkage of vestibular schwannomas after Gamma Knife surgery: results after more than 5 years of follow-up.
  • OBJECT: The authors prospectively analyzed volume changes in vestibular schwannomas (VSs) after Gamma Knife surgery (GKS).
  • RESULTS: The mean tumor volume at GKS was 2.5 cm3 (range 0.1–13.2 cm3).
  • The lesions were irradiated by directing a mean dose of 12.0 Gy (range 10.5–13.0 Gy) to the tumor margin, which was located at the mean 52.2% isodose line (range 50%–67% isodose line).
  • Peak tumor volume expansion was most frequently observed at 8.6 months after GKS and averaged 58% (range 0%–613%).
  • Five years after GKS, the mean reduction in tumor volume was 31%, and 9 tumors still remained larger than their initial volumes.
  • Tumors that homogeneously enhanced on MR images displayed less shrinkage than other tumors.
  • These results indicate that careful serial follow-up is necessary for patients who harbor tumors that display homogeneous enhancement on MR images and patients whose tumors continue to expand in size after GKS. (DOI: 10.3171/2010.8.GKS10960)
  • [MeSH-major] Ear Neoplasms / surgery. Neuroma, Acoustic / surgery. Radiosurgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Echo-Planar Imaging. Female. Follow-Up Studies. Humans. Longitudinal Studies. Male. Middle Aged. Paresthesia / etiology. Prognosis. Treatment Outcome. Trigeminal Nerve Diseases / etiology

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  • (PMID = 21222292.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Parietti-Winkler C, Gauchard GC, Simon C, Perrin PP: Long-term effects of vestibular compensation on balance control and sensory organisation after unilateral deafferentation due to vestibular schwannoma surgery. J Neurol Neurosurg Psychiatry; 2010 Aug;81(8):934-6
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  • [Title] Long-term effects of vestibular compensation on balance control and sensory organisation after unilateral deafferentation due to vestibular schwannoma surgery.
  • The time-course of central adaptive mechanisms after vestibular schwannoma surgical removal allows, 3 months after surgery (middle term), a satisfactory recovery of balance control.
  • This longitudinal prospective study aimed to assess the long-term effects of vestibular compensation on balance control and sensory organisation in patients operated on for vestibular schwannoma.
  • Thirty-six patients with vestibular schwannoma underwent vestibular and sensory organisation tests, shortly before and 3 months, 6 months and 1 year after surgery.
  • Postural control performances improved 3 months after surgery compared with before surgery; they continued to improve at 6 and 12 months after surgery, especially in conditions highly soliciting vestibular information.
  • In the long term, strategies based on sensorimotor and/or behavioural substitution seem to be reinforced and fine-tuned, particularly in complex postural situations, for which only vestibular information is reliable to control balance.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Neuroma, Acoustic / surgery. Postural Balance / physiology. Sensation / physiology. Vestibule, Labyrinth / physiopathology. Vestibule, Labyrinth / surgery. Vestibulocochlear Nerve / surgery
  • [MeSH-minor] Adult. Denervation. Female. Follow-Up Studies. Humans. Longitudinal Studies. Male. Middle Aged. Postoperative Period. Prospective Studies. Reflex, Vestibulo-Ocular / physiology. Vestibular Function Tests

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  • (PMID = 20682722.001).
  • [ISSN] 1468-330X
  • [Journal-full-title] Journal of neurology, neurosurgery, and psychiatry
  • [ISO-abbreviation] J. Neurol. Neurosurg. Psychiatry
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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24. Bernat I, Vitte E, Lamas G, Soudant J, Willer JC, Tankéré F: Related timing for peripheral and central plasticity in hypoglossal-facial nerve anastomosis. Muscle Nerve; 2006 Mar;33(3):334-41
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  • [Title] Related timing for peripheral and central plasticity in hypoglossal-facial nerve anastomosis.
  • An electrophysiological study was performed on seven patients who underwent HFA after facial nerve transection during surgery for acoustic neuroma.
  • The occurrence of peripheral nerve-muscle contacts seems to be a necessary condition for reorganization of the trigemino-hypoglossal-facial reflex.
  • [MeSH-major] Central Nervous System / physiopathology. Facial Nerve / surgery. Hypoglossal Nerve / surgery. Neuronal Plasticity / physiology. Neurosurgical Procedures. Peripheral Nervous System / physiopathology
  • [MeSH-minor] Adult. Aged. Blinking / physiology. Data Interpretation, Statistical. Electric Stimulation. Electrophysiology. Facial Muscles / innervation. Facial Muscles / surgery. Female. Follow-Up Studies. Humans. Male. Middle Aged. Nerve Regeneration. Neuroma, Acoustic / surgery. Oculomotor Muscles / physiology. Reflex / physiology. Treatment Outcome

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  • [Copyright] Muscle Nerve, 2006.
  • (PMID = 16307440.001).
  • [ISSN] 0148-639X
  • [Journal-full-title] Muscle & nerve
  • [ISO-abbreviation] Muscle Nerve
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Patni AH, Kartush JM: Staged resection of large acoustic neuromas. Otolaryngol Head Neck Surg; 2005 Jan;132(1):11-9
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  • [Title] Staged resection of large acoustic neuromas.
  • OBJECTIVE: Surgical removal of large (>3 cm) acoustic neuromas is associated with poor long-term facial nerve function results and higher complication rates.
  • This study analyzes whether long term facial nerve function and the incidence of neurological and vascular complications is improved by resection of large acoustic neuromas in 2 or 3 stages.
  • PATIENTS AND METHODS: Among 660 patients who underwent surgical resection of acoustic neuromas between 1989 and 2002 by the senior author (J.M.K.
  • ), 34 (5%) patients underwent a staged resection of their large-sized tumors: stage I via a retrosigmoid craniotomy and stage II via a translabyrinthine approach.
  • Tumor size, completeness of tumor removal, tumor recurrence, facial nerve function, and any complications were noted.
  • RESULTS: The average tumor size was 4.4 cm with a mean postoperative length of follow-up of 6 years after the last surgery.
  • There were no tumor recurrences on follow-up MRI scans.
  • CONCLUSION: In conjunction with the reported technical refinements, staged resection of large tumors significantly reduces morbidity and improves long-term facial nerve function.
  • [MeSH-major] Neuroma, Acoustic / surgery
  • [MeSH-minor] Facial Nerve / physiology. Facial Nerve Diseases / prevention & control. Female. Follow-Up Studies. Humans. Male. Otologic Surgical Procedures / adverse effects. Otologic Surgical Procedures / methods. Postoperative Complications / epidemiology. Postoperative Complications / etiology. Retrospective Studies

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  • (PMID = 15632903.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Bush ML, Jones RO, Shinn JB: Auditory brainstem response threshold differences in patients with vestibular schwannoma: a new diagnostic index. Ear Nose Throat J; 2008 Aug;87(8):458-62
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  • [Title] Auditory brainstem response threshold differences in patients with vestibular schwannoma: a new diagnostic index.
  • Auditory brainstem response (ABR) testing is less sensitive in detecting small vestibular schwannomas than medium-size tumors.
  • Magnetic resonance imaging (MRI) is more sensitive than ABR alone for small and large tumors, but it carries with it increased cost and issues of unavailability and patient discomfort.
  • We conducted a prospective pilot study of 7 patients with untreated MRI-proven, unilateral vestibular schwannoma to determine if we could increase the sensitivity of ABR testing in detecting small tumors.
  • [MeSH-major] Brain Stem / pathology. Evoked Potentials, Auditory, Brain Stem. Neuroma, Acoustic / diagnosis

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  • (PMID = 18712694.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. De la Cruz A, Teufert KB: Transcochlear approach to cerebellopontine angle and clivus lesions: indications, results, and complications. Otol Neurotol; 2009 Apr;30(3):373-80
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  • Patients were grouped by whether the facial nerve was mobilized (TC, n = 15) or not (TO, n = 25).
  • MAIN OUTCOME MEASURES: Indications, postoperative outcomes, and complications including tumor removal and facial nerve status (House-Brackmann grade).
  • RESULTS: Forty percent of all TC patients were meningiomas, whereas 36% of all TO patients were cochlear neuromas.
  • The remainder included tumors associated with NF2, acoustic tumors, malignancies, and other lesions.
  • Complete removal was achieved in 92.5% of tumors.
  • Of all patients, 42% and 55% had normal facial nerve function at the time of hospital discharge and follow up, respectively.
  • Moreover, 22% underwent a facial nerve reanastomosis procedure.
  • CONCLUSION: The TC and TO approaches provide access to midline intradural lesions, intradural petroclival tumors, and cerebellopontine angle tumors and cholesteatomas arising anterior to the internal auditory canal, without using brain retractors.
  • Total tumor removal, including its base and blood supply, is possible.
  • Facial weakness is frequent when the facial nerve is rerouted, but excellent facial nerve results are accomplished with the TO approach.
  • With these approaches, recurrence israre when all tumor has been removed.
  • [MeSH-minor] Adolescent. Adult. Aged. Carotid Arteries / anatomy & histology. Child, Preschool. Data Interpretation, Statistical. Ear Canal / anatomy & histology. Ear Canal / surgery. Facial Nerve / physiology. Facial Nerve / surgery. Female. Humans. Magnetic Resonance Imaging. Male. Meningioma / surgery. Middle Aged. Neoplasm Recurrence, Local. Treatment Outcome. Young Adult

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  • (PMID = 19318889.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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28. Hong SJ, Lee JH, Jung SH, Park CH, Hong SM: Can cochlear function be preserved after a modified translabyrinthine approach to eradicate a huge cholesteatoma extending to the petrous apex? Eur Arch Otorhinolaryngol; 2009 Aug;266(8):1191-7
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  • We concluded that the modified translabyrinthine approach is useful for preserving hearing postoperatively when a huge cholesteatoma exists involving the petrous region or a vestibular schwannoma in the internal auditory canal or cerebellopontine angle.
  • [MeSH-major] Catheter Ablation / methods. Cholesteatoma, Middle Ear / surgery. Cochlea / physiopathology. Cochlear Nerve / surgery. Hearing / physiology. Petrous Bone / surgery. Vestibule, Labyrinth / surgery

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  • [Cites] J Laryngol Otol. 1990 Dec;104(12):945-8 [2280147.001]
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  • (PMID = 19034472.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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29. Montaguti M, Bergonzoni C, Zanetti MA, Rinaldi Ceroni A: Comparative evaluation of ABR abnormalities in patients with and without neurinoma of VIII cranial nerve. Acta Otorhinolaryngol Ital; 2007 Apr;27(2):68-72
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  • [Title] Comparative evaluation of ABR abnormalities in patients with and without neurinoma of VIII cranial nerve.
  • Although the diagnostic reliability of auditory brainstem responses (ABR) in acoustic neuromas has been revised due to its poor sensitivity (demonstrated above all in smaller tumours), and its limited specificity, this method is still used as the initial otoneurological approach.
  • To contribute to the clinical use of this method, in particular with the aim of reducing the number of false positives, a retrospective study was carried out in two groups of patients affected by unilateral sensorineural hearing loss with auditory brainstem response abnormalities: in the first group (50 cases: true positives) hearing loss was the expression of an acoustic neuroma shown by magnetic resonance imaging, in the second group (130: false positives) magnetic resonance imaging was negative.
  • A comparison between the two groups made it possible to show that the finding of "major" auditory brainstem response alterations (complete absence of response not justified by the extent of the hearing loss or presence of only wave I) is correlated with a high probability of the presence of a neuroma, while other abnormalities (wave V latency and I-V interpeak latency increase) have no particular predictive value since percentages are almost identical in the two groups.
  • Wave V latency increase with normal I-V interpeak latency was observed in only one case of acoustic neuroma and this clinical finding is not easy to interpret.
  • [MeSH-major] Evoked Potentials, Auditory, Brain Stem / physiology. Neuroma, Acoustic / diagnosis. Neuroma, Acoustic / physiopathology

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  • (PMID = 17608133.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2640003
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30. Bakkouri WE, Kania RE, Guichard JP, Lot G, Herman P, Huy PT: Conservative management of 386 cases of unilateral vestibular schwannoma: tumor growth and consequences for treatment. J Neurosurg; 2009 Apr;110(4):662-9
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  • [Title] Conservative management of 386 cases of unilateral vestibular schwannoma: tumor growth and consequences for treatment.
  • OBJECT: The object of this study was to evaluate the natural history, pattern, and occurrence of tumor growth and its consequences for treatment of small-sized vestibular schwannomas (VSs).
  • METHODS: From 1990 to 2005, 386 patients underwent conservative management for VS because of the following: age > 60 years, poor health/medical risks, risk of deterioration of good hearing, small tumor size, minimal or no incapacitating symptoms, and/or patient preference.
  • Tumor size was measured by MR imaging according to the guidelines of the Committee on Hearing and Equilibrium.
  • The first MR imaging study was performed 1 year after diagnosis, and subsequent imaging was performed yearly or every 2 years depending on the appearance of new symptoms, tumor growth, or both.
  • Of the 325 patients for whom 1-year follow-up data were available, 39 showed tumor growth > or = 3 mm.
  • The patients who returned for follow-up were evaluated at 1- or 2-year intervals depending on tumor growth.
  • The overall mean tumor growth rate (+/-standard deviation) was 1.15 +/- 2.4 mm/year.
  • This rate was estimated by pooling all values of tumor growth that had been determined for all patients and dividing by the total number of "events," with each assessment constituting an event.
  • In 58.6% of patients, the annual tumor growth rate was < 1 mm/year; in 29.2%, 1-3 mm/year; and in 12.2%, > or = 3 mm/ year.
  • The growth rates of intrameatal (1.02 +/- 1.8 mm/year) and extrameatal (1.40 +/- 3.1 mm/year) tumors did not differ significantly.
  • No significant association was found between tumor growth rate and sex, age, initial hearing status, or initial tumor grade.
  • Delay in diagnosis was the only significant factor associated with tumor growth rate.
  • Long-term neuroimaging follow-up is needed even with non-growing tumors.
  • [MeSH-major] Neuroma, Acoustic / therapy

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  • (PMID = 19099381.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Vorasubin N, Sang U H, Mafee M, Nguyen QT: Glossopharyngeal schwannomas: a 100 year review. Laryngoscope; 2009 Jan;119(1):26-35
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  • [Title] Glossopharyngeal schwannomas: a 100 year review.
  • OBJECTIVES: To review the literature on glossopharyngeal schwannomas with a focus on clinical presentation, radiologic/audiologic characteristics, and management options, and to propose a mechanism explaining the nature of vestibulocochlear dysfunction seen with these tumors.
  • METHODS: English literature search for cases of primary isolated glossopharyngeal schwannomas and chart review of two new cases.
  • RESULTS: A total of 42 glossopharyngeal schwannoma cases between 1908-2008 were reviewed.
  • Tumors can occur anywhere along the CNIX; however, the majority of symptomatic cases are intracranial/intraosseous, which present with vestibulocochlear dysfunction.
  • Reviewed cases typically described the caliber of CNVII and VIII on CT/MRI as normal.
  • We present a case where notching and displacement of CNVIII by the tumor can be appreciated on MRI, allowing for the first correlation between clinical symptoms and imaging findings.
  • Mid frequency SNHL was prevalent in contrast to the high-frequency pattern typical of vestibular schwannomas.
  • Tonotopic studies of CNVIII mapped low-to-mid frequency fibers along the posterior medial surface corresponding to the area of greatest compression by glossopharyngeal schwannomas.
  • CONCLUSION: Glossopharyngeal schwannomas usually present with vestibulocochlear rather than glossopharyngeal symptoms, likely due to CNVIII compression and displacement by tumor, which can be better appreciated with modern imaging.
  • The tumor's location posterior and medial to CNVIII combined with the complex CNVIII tonotopic organization may account for the preferential mid-frequency hearing loss seen in these patients.
  • [MeSH-major] Glossopharyngeal Nerve Diseases / diagnosis. Glossopharyngeal Nerve Diseases / surgery. Neurilemmoma / diagnosis. Neurilemmoma / surgery

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  • (PMID = 19117318.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 39
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32. Anderson DE, Leonetti J, Wind JJ, Cribari D, Fahey K: Resection of large vestibular schwannomas: facial nerve preservation in the context of surgical approach and patient-assessed outcome. J Neurosurg; 2005 Apr;102(4):643-9
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  • [Title] Resection of large vestibular schwannomas: facial nerve preservation in the context of surgical approach and patient-assessed outcome.
  • OBJECT: Vestibular schwannoma surgery has evolved as new therapeutic options have emerged, patients' expectations have risen, and the psychological effect of facial nerve paralysis has been studied.
  • For large vestibular schwannomas for which extirpation is the primary therapy, the goals remain complete tumor resection and maintenance of normal neurological function.
  • Improved microsurgical techniques and intraoperative facial nerve monitoring have decreased the complication rate and increased the likelihood of normal to near-normal postoperative facial function.
  • Nevertheless, the impairment most frequently reported by patients as an adverse effect of surgery continues to be facial nerve paralysis.
  • The authors evaluated the extent of facial function, timing of facial nerve recovery, patients' perceptions of this recovery and function, and the prognostic value of intraoperative facial nerve monitoring following resection of large vestibular schwannomas; they then analyzed these results with respect to different surgical approaches.
  • METHODS: The authors retrospectively reviewed a database of 67 patients with 71 vestibular schwannomas measuring 3 cm or larger in diameter.
  • Clinical outcomes were analyzed with respect to intraoperative facial nerve activity, responses to intraoperative stimulation, and time course of recovery.
  • Patients' perceptions of facial nerve function and recovery correlated well with the clinical observations.
  • CONCLUSIONS: Trends in the data lead the authors to suggest that a retrosigmoid exposure, alone or in combination with a translabyrinthine approach, offers the best chance of facial nerve preservation in patients with large vestibular schwannomas.
  • [MeSH-major] Facial Nerve Injuries / etiology. Facial Nerve Injuries / prevention & control. Facial Paralysis / etiology. Facial Paralysis / prevention & control. Neuroma, Acoustic / surgery. Neurosurgical Procedures / methods

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  • [CommentIn] J Neurosurg. 2006 Jan;104(1):175-6; author reply 176 [16509164.001]
  • (PMID = 15871506.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Obrebowski A, Wiskirska-Woźnica B, Czerniejewska H: [Binaural asymmetric sensorineural hearing loss in audiological practice]. Otolaryngol Pol; 2010 Nov-Dec;64(6):382-4
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  • After audiological examination 14% of this patients were qualified for MRI investigation, in 2 (3%) of them acoustic neurinoma was found.

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  • (PMID = 21302506.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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34. Okamoto K, Furusawa T, Ishikawa K, Sasai K, Tokiguchi S: Focal T2 hyperintensity in the dorsal brain stem in patients with vestibular schwannoma. AJNR Am J Neuroradiol; 2006 Jun-Jul;27(6):1307-11
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  • [Title] Focal T2 hyperintensity in the dorsal brain stem in patients with vestibular schwannoma.
  • BACKGROUND AND PURPOSE: The vestibular nucleus cannot be visualized on MR imaging, but some patients with vestibular schwannoma show a tiny area of hyperintensity in the dorsal brain stem on T2-weighted images.
  • The aim of this study was to determine whether this tiny area is characteristic of vestibular schwannoma.
  • METHODS: We retrospectively reviewed the postoperative MR images of 53 patients with cerebellopontine angle tumor.
  • Surgical and histopathologic diagnosis was vestibular schwannoma (41/53 = 77%), meningioma (7/53 = 13%), epidermoid cyst (3/53 = 6%), glioma with exophytic growth (1/53 = 2%), and chordoma (1/53 = 2%).
  • RESULTS: A tiny area of hyperintensity was observed at the lateral angle of the fourth ventricle floor in 6 patients (3 men, 3 women; age range, 24-54 years; mean age, 43 years) with vestibular schwannoma larger than 2 cm in maximal diameter on both FSE T2-weighted and CISS images.
  • CONCLUSION: Because the location of the area of hyperintensity is coincident with the vestibular nucleus, the hyperintensity may represent degeneration of the nucleus.
  • If such hyperintensity is seen in a patient with a large cerebellopontine angle tumor, a diagnosis of vestibular schwannoma is suggested.
  • [MeSH-major] Brain Stem / pathology. Magnetic Resonance Imaging. Neuroma, Acoustic / diagnosis

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  • (PMID = 16775286.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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35. Pons Y, Gauthier J, Dagain A, Conessa C, Clement P, Desgeorges M, Poncet JL: [Long-term results of facial palsy's rehabilitation by end-to-end hypoglossal-facial anastomosis]. Rev Laryngol Otol Rhinol (Bord); 2009;130(3):169-74
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  • [Transliterated title] Résultats à long terme de la réhabilitation des paralysies faciales périphériques par anastomose hypoglosso-faciale termino-terminale.
  • PATIENTS AND METHODS: In this retrospective study, 11 patients (8 males and 3 females) with a complete facial palsy (grade VI House-Brackmann) due to an otoneurosurgery performed between 1985 and 2006 (6 vestibular schwannomas, 1 facial schwannoma of the geniculate ganglion and 4 meningiomas) were evaluated (with the help of an auto-questionnary, a physical exam and electromyography) between July and september in 2008.
  • [MeSH-major] Facial Nerve / surgery. Facial Paralysis / rehabilitation. Hypoglossal Nerve / surgery

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  • (PMID = 20345073.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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36. Schneider AB, Ron E, Lubin J, Stovall M, Shore-Freedman E, Tolentino J, Collins BJ: Acoustic neuromas following childhood radiation treatment for benign conditions of the head and neck. Neuro Oncol; 2008 Feb;10(1):73-8
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  • [Title] Acoustic neuromas following childhood radiation treatment for benign conditions of the head and neck.
  • Childhood radiation exposure has been associated with an increased risk for developing several neoplasms, particularly benign and malignant thyroid tumors, but little is known about the risk of developing acoustic neuromas.
  • The aim of this study was to confirm whether there is a risk for acoustic neuromas and, if so, to determine its magnitude and duration.
  • We investigated the time trend and dose-response relationships for acoustic neuroma incidence in a cohort of 3,112 individuals who were irradiated as children between 1939 and 1962.
  • Most of the patients were treated to reduce the size of their tonsils and adenoids and received substantial radiation exposure to the cerebellopontine angle, the site of acoustic neuromas.
  • Forty-three patients developed benign acoustic neuromas, forty of them surgically resected, far in excess of what might be expected from data derived from brain tumor registries.
  • Our study provides support for an association between acoustic neuromas and childhood radiation exposure.
  • Although acoustic neuromas are usually benign and often asymptomatic, many cause significant morbidity.
  • Any symptoms of an acoustic neuroma in a patient with a history of radiation to the head and neck area should be investigated carefully, and the threshold for employing imaging should be lowered.

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  • (PMID = 18079359.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA-21518; United States / NCI NIH HHS / CP / N01-CP-85604; United States / NCI NIH HHS / CP / N01-CP-95614; United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2600840
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37. Lin VY, Houlden D, Bethune A, Nolan M, Pirouzmand F, Rowed D, Nedzelski JM, Chen JM: A novel method in predicting immediate postoperative facial nerve function post acoustic neuroma excision. Otol Neurotol; 2006 Oct;27(7):1017-22
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  • [Title] A novel method in predicting immediate postoperative facial nerve function post acoustic neuroma excision.
  • To determine whether the percentage calculated by dividing the amplitude of postexcision direct facial nerve stimulus responses (at pontomedullary junction) by the amplitude of distal ipsilateral transcutaneous (stylomastoid region) maximal stimulus responses and response amplitude progression by increasing stimulus intensities have predictive value for determining normal or near-normal (House-Brackmann Grade 1 or 2) immediate postoperative facial nerve function.
  • Postexcision direct facial nerve stimulation at the pontomedullary junction and transcutaneous maximal facial nerve stimulation at the ipsilateral stylomastoid region and their associated response amplitudes were recorded.
  • PATIENTS AND METHODS: Patients who underwent acoustic neuroma surgery from January 2004 to March 2006 with intraoperative facial nerve monitoring and an intact facial nerve after tumor excision were included.
  • CONCLUSION: The percentage of the response amplitude of direct facial nerve stimulation at the pontomedullary junction when compared with the maximum response amplitude of ipsilateral transcutaneous stimulation at the stylomastoid foramen is a good predictor of normal to near-normal immediate postoperative facial nerve function.
  • Progression of amplitude response also seems to be a good predictor of normal to near-normal immediate postoperative facial nerve function.
  • [MeSH-major] Facial Nerve / physiopathology. Monitoring, Intraoperative. Neuroma, Acoustic / surgery
  • [MeSH-minor] Adult. Aged. Electric Stimulation. Facial Nerve Injuries / prevention & control. Facial Paralysis / prevention & control. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Treatment Outcome

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  • (PMID = 17006353.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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38. Blettner M, Schlehofer B, Samkange-Zeeb F, Berg G, Schlaefer K, Schüz J: Medical exposure to ionising radiation and the risk of brain tumours: Interphone study group, Germany. Eur J Cancer; 2007 Sep;43(13):1990-8
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  • [Title] Medical exposure to ionising radiation and the risk of brain tumours: Interphone study group, Germany.
  • BACKGROUND: The role of exposure to low doses of ionising radiation in the aetiology of brain tumours has yet to be clarified.
  • The objective of this study was to investigate the association between medically or occupationally related exposure to ionising radiation and brain tumours.
  • METHODS: We used self-reported medical and occupational data collected during the German part of a multinational case-control study on mobile phone use and the risk of brain tumours (Interphone study) for the analyses.
  • RESULTS: For any exposure to medical ionising radiation we found odds ratios (ORs) of 0.63 (95% confidence interval (CI)=0.48-0.83), 1.08 (95% CI=0.80-1.45) and 0.97 (95% CI=0.54-1.75) for glioma, meningioma and acoustic neuroma, respectively.
  • Elevated ORs were found for meningioma (OR 2.32, 95% CI: 0.90-5.96) and acoustic neuroma (OR 6.45, 95% CI: 0.62-67.16) for radiotherapy to the head and neck regions.
  • CONCLUSION: We did not find any significant increased risk of brain tumours for exposure to medical ionising radiation.
  • [MeSH-major] Brain Neoplasms / etiology. Cell Phones. Neoplasms, Radiation-Induced / etiology. Occupational Exposure / adverse effects

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  • (PMID = 17689954.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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39. Ahmad SM, Garcia F, Sataloff RT: Cerebellopontine angle ganglionic hamartoma: case report. Ear Nose Throat J; 2010 Mar;89(3):128-31
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  • Magnetic resonance imaging revealed a mass on the intracanalicular segment of cranial nerve VIII on the left side, consistent with acoustic schwannoma.
  • She opted for observation of the tumor.
  • At this time, a working diagnosis of facial nerve neuroma was made.
  • Otolaryngologists should be familiar with this uncommon tumor and include it in the differential diagnosis of CPA lesions.
  • [MeSH-minor] Cochlear Nerve / physiopathology. Evoked Potentials, Auditory, Brain Stem. Facial Nerve Diseases / diagnosis. Facial Nerve Diseases / etiology. Female. Humans. Middle Aged

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  • (PMID = 20229478.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Brantberg K: Vestibular evoked myogenic potentials (VEMPs): usefulness in clinical neurotology. Semin Neurol; 2009 Nov;29(5):541-7
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  • [Title] Vestibular evoked myogenic potentials (VEMPs): usefulness in clinical neurotology.
  • Testing vestibular evoked myogenic potentials (VEMPs) may be the most important new clinical test for evaluation of vestibular function developed during the past 100 years since the introduction of the caloric test.
  • VEMPs in response to air-conducted sound stimulation using surface electrodes over the sternocleidomastoid muscles reveal saccular function, inferior vestibular nerve function, and vestibulocollic connections.
  • At present, VEMPs are of clinical importance for estimating the severity of peripheral vestibular damage due to different pathophysiologic processes such as Ménière's disease, vestibular neuritis, and vestibular schwannoma.
  • VEMPs can also be used to document vestibular hypersensitivity to sounds (Tullio phenomenon).
  • In addition, VEMP testing constitutes an electrophysiologic method that is able to detect subclinical lesions in central vestibular pathways in patients with multiple sclerosis.
  • [MeSH-major] Evoked Potentials. Vestibular Diseases / physiopathology
  • [MeSH-minor] Animals. Humans. Meniere Disease / diagnosis. Meniere Disease / physiopathology. Multiple Sclerosis / diagnosis. Multiple Sclerosis / physiopathology. Neurology / methods. Neuroma, Acoustic / diagnosis. Neuroma, Acoustic / physiopathology. Otolaryngology / methods. Vestibular Neuronitis / diagnosis. Vestibular Neuronitis / physiopathology

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  • [Copyright] Thieme Medical Publishers.
  • (PMID = 19834866.001).
  • [ISSN] 1098-9021
  • [Journal-full-title] Seminars in neurology
  • [ISO-abbreviation] Semin Neurol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 44
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41. Hanemann CO, Bartelt-Kirbach B, Diebold R, Kämpchen K, Langmesser S, Utermark T: Differential gene expression between human schwannoma and control Schwann cells. Neuropathol Appl Neurobiol; 2006 Dec;32(6):605-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differential gene expression between human schwannoma and control Schwann cells.
  • The mutation of a single allele of this gene causes the autosomal dominantly inherited disease neurofibromatosis type 2 (NF2), which is characterized mainly by vestibular schwannoma carrying a second hit mutation.
  • Complete lack of merlin is also found in spontaneous schwannomas and meningiomas.
  • As the events leading to schwannoma development are largely unknown we investigated the differences in gene expression between schwannoma cells from NF2 patients and normal human primary Schwann cells by cDNA array analysis.
  • By this method a total of seven genes with increased and seven genes with decreased mRNA levels in schwannoma compared with normal Schwann cells could be identified.
  • Regulated clones, some of which not been described in Schwann cells earlier, included matrix metalloproteinase's, growth factors, growth factor receptors and tyrosine kinases.
  • [MeSH-major] Gene Expression. Neurilemmoma / genetics. Neurofibromatosis 2 / genetics. Schwann Cells / physiology

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  • (PMID = 17083475.001).
  • [ISSN] 0305-1846
  • [Journal-full-title] Neuropathology and applied neurobiology
  • [ISO-abbreviation] Neuropathol. Appl. Neurobiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Messenger
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42. Corona AP, Oliveira JC, Souza FP, Santana LV, Rêgo MA: Risk factors associated with vestibulocochlear nerve schwannoma: systematic review. Braz J Otorhinolaryngol; 2009 Jul-Aug;75(4):593-615
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  • [Title] Risk factors associated with vestibulocochlear nerve schwannoma: systematic review.
  • The vestibulocochlear nerve schwannoma (VS) is a benign tumor that stems from the edge of the Schwann s sheath.
  • It is considered the most frequent intracranial benign tumor, of low lethality rate and unknown etiology.
  • METHODS: electronic search of studies using the following key words: 'risk', 'schwannoma', 'vestibular', 'neuroma' and 'acoustic'.
  • [MeSH-major] Environmental Exposure / adverse effects. Neuroma, Acoustic / etiology

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  • (PMID = 19784431.001).
  • [ISSN] 1808-8686
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Brazil
  • [Number-of-references] 49
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43. Petrovic BD, Futterer SF, Hijaz T, Russell EJ, Karagianis AG: Frequency and diagnostic utility of intralabyrinthine FLAIR hyperintensity in the evaluation of internal auditory canal and inner ear pathology. Acad Radiol; 2010 Aug;17(8):992-1000
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: Twenty-five of 32 (78%) patients with schwannomas restricted to the IAC and cerebellopontine angle demonstrated associated increased FLAIR signal within the ipsilateral inner ear structures.
  • The sensitivity, specificity, positive predictive value, and negative predictive value of inner ear FLAIR hyperintensity for a schwannoma were 80%, 95%, 78%, and 95%, respectively.
  • Although enhancement after the administration of gadolinium contrast media is the gold standard for detection of schwannoma, inner ear FLAIR hyperintensity may be a helpful diagnostic adjunct for vestibular schwannoma.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Ear Neoplasms / pathology. Female. Humans. Male. Middle Aged. Neurilemmoma / pathology. Young Adult

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  • (PMID = 20605731.001).
  • [ISSN] 1878-4046
  • [Journal-full-title] Academic radiology
  • [ISO-abbreviation] Acad Radiol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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44. Dublin A: Acoustic neuroma or vestibular schwannoma? Skull Base; 2009 Sep;19(5):375
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  • [Title] Acoustic neuroma or vestibular schwannoma?

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  • (PMID = 20190950.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2765706
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45. Javadpour M: Management of vestibular schwannomas in children: a role for adult surgeons in the paediatric world? and the merits of centralisation? Br J Neurosurg; 2009 Jun;23(3):232-3
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  • [Title] Management of vestibular schwannomas in children: a role for adult surgeons in the paediatric world? and the merits of centralisation?
  • [MeSH-major] Facial Nerve / surgery. Neurofibromatosis 2 / surgery. Neuroma, Acoustic / surgery

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  • [CommentOn] Br J Neurosurg. 2009 Jun;23(3):226-31 [19533454.001]
  • (PMID = 19533455.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] England
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46. Bartoszewicz R, Niemczyk K, Marchel A, Kowalska M: [Sudden deafness as a presentation of acoustic neuroma]. Pol Merkur Lekarski; 2005 Sep;19(111):307-8
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  • [Title] [Sudden deafness as a presentation of acoustic neuroma].
  • [Transliterated title] Nagła głuchota w symptomatologii guzów nerwu VIII.
  • Acoustic neuroma should always be considered in the differential diagnosis.
  • The authors analysed symptoms occurring in the group of 89 patients, diagnosed with acoustic neuroma.
  • A special attention was paid to the role of sudden deafness as a clinical manifestation of the VIIIth nerve pathology.
  • [MeSH-major] Deafness / etiology. Headache / etiology. Hearing Loss, Sensorineural / etiology. Neuroma, Acoustic / complications. Neuroma, Acoustic / diagnosis. Tinnitus / etiology


47. Martinez Del Pero M, Lloyd SK, Moffat DA: Hearing improvement in a growing vestibular schwannoma. Skull Base; 2009 Mar;19(2):159-62
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  • [Title] Hearing improvement in a growing vestibular schwannoma.
  • Vestibular schwannomas are benign, slow-growing tumors that originate from Schwann cells lining the vestibular nerves, most commonly the superior vestibular nerve.
  • A case of a patient undergoing a period of observation for a vestibular schwannoma whose hearing improved despite growth of the tumor is described.
  • This raises interesting questions regarding the pathophysiology of hearing loss in patients with vestibular schwannomas.

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  • (PMID = 19721772.001).
  • [ISSN] 1531-5010
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2671297
  • [Keywords] NOTNLM ; Vestibular schwannoma / acoustic neuroma / follow-up / hearing
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48. Cotton CA, Beall DP, Winter BJ, Fortman BJ, Kirby AB, Ly JQ: Cavernous angioma of the cerebellopontine angle. Curr Probl Diagn Radiol; 2006 May-Jun;35(3):120-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We describe a case that was initially mistaken for a vestibular schwannoma due to its location in the cerebellopontine angle.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Cerebellopontine Angle / pathology. Hemangioma, Cavernous / diagnosis. Neurilemmoma / diagnosis

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  • (PMID = 16701123.001).
  • [ISSN] 0363-0188
  • [Journal-full-title] Current problems in diagnostic radiology
  • [ISO-abbreviation] Curr Probl Diagn Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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49. Stieglitz LH, Giordano M, Gerganov V, Raabe A, Samii A, Samii M, Lüdemann WO: Petrous bone pneumatization is a risk factor for cerebrospinal fluid fistula following vestibular schwannoma surgery. Neurosurgery; 2010 Dec;67(2 Suppl Operative):509-15
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  • [Title] Petrous bone pneumatization is a risk factor for cerebrospinal fluid fistula following vestibular schwannoma surgery.
  • OBJECTIVE: To identify the petrous bone air cell volume as a risk factor for developing CSF fistula, we performed a retrospective analysis.
  • METHODS: From 2000 to 2007 519 patients had a retrosigmoidal surgical removal of a vestibular schwannoma.
  • The 22 who had a postoperative CSF fistula were chosen for evaluation in addition to 78 patients who were randomly selected in 4 equally sized cohorts: male/female with small/large tumors.
  • Preoperative CT scans were analyzed regarding petrous bone air cell volume, area of visible pneumatization at the level of the internal auditory canal (IAC), tumor grade, and sex.
  • The mean air cell volume of CSF-fistula patients was 13.72 mL (SD, 5.22).
  • The difference concerning the air cell volume between patients who developed CSF fistulas and patients from the control group was significant (P = .0042).
  • There was a significant positive correlation between the air cell volume and the area of pneumatization in one CT slide at the level of the IAC.
  • A high amount of petrous bone pneumatization has to be considered as a risk factor for the development of postoperative CSF fistula after vestibular schwannoma surgery.
  • [MeSH-major] Cerebrospinal Fluid Rhinorrhea / etiology. Neuroma, Acoustic / surgery. Petrous Bone / abnormalities. Petrous Bone / surgery. Postoperative Complications / etiology


50. House WF, Shelton C: Middle fossa approach for acoustic tumor removal. 1992. Neurosurg Clin N Am; 2008 Apr;19(2):279-88, vi
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  • [Title] Middle fossa approach for acoustic tumor removal. 1992.
  • The middle fossa approach is useful for the removal of small acoustic tumors when hearing preservation is possible.
  • This approach provides complete exposure of the contents of the internal auditory canal and positive facial nerve identification.
  • Because access to the posterior fossa is limited, the middle fossa approach is most appropriate for tumors with less than 5 mm extension into the cerebellopontine angle.
  • With the introduction of gadolinium-enhanced magnetic resonance imaging, very small acoustic tumors are diagonosed more frequently, and the middle fossa approach is well-suited for the removal of these tumors.
  • [MeSH-major] Craniotomy / history. Neuroma, Acoustic / history

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  • (PMID = 18534340.001).
  • [ISSN] 1558-1349
  • [Journal-full-title] Neurosurgery clinics of North America
  • [ISO-abbreviation] Neurosurg. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Biography; Classical Article; Historical Article; Journal Article
  • [Publication-country] United States
  • [Personal-name-as-subject] House WF; Shelton C
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51. Piedra MP, Scheithauer BW, Driscoll CL, Link MJ: Primary melanocytic tumor of the cerebellopontine angle mimicking a vestibular schwannoma: case report. Neurosurgery; 2006 Jul;59(1):E206; discussion E206
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  • [Title] Primary melanocytic tumor of the cerebellopontine angle mimicking a vestibular schwannoma: case report.
  • OBJECTIVE: The majority of tumors of the cerebellopontine angle (CPA) are benign.
  • We report the case of a primary malignant melanoma of the CPA that mimicked a vestibular schwannoma (acoustic neuroma).
  • A neurological work-up revealed a large tumor in the left CPA radiographically diagnosed as a vestibular schwannoma.
  • INTERVENTION: A translabyrinthine approach revealed a pigmented, vascular neoplasm encasing vessels and cranial nerves of the left CPA.
  • The tumor was subtotally resected, and a histopathological diagnosis of melanoma was made.
  • The patient had no history of cutaneous melanoma and no other site of disease was ever discovered.
  • CONCLUSION: This case most likely represents primary melanoma of the central nervous system that mimicked a vestibular schwannoma.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Cerebellopontine Angle. Melanocytes / pathology. Melanoma / diagnosis. Neuroma, Acoustic / diagnosis


52. Goodwin L: Acoustic neuroma and radiosurgery. J Insur Med; 2007;39(1):44-6
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  • [Title] Acoustic neuroma and radiosurgery.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / methods. Treatment Outcome

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  • (PMID = 17500357.001).
  • [ISSN] 0743-6661
  • [Journal-full-title] Journal of insurance medicine (New York, N.Y.)
  • [ISO-abbreviation] J Insur Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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53. Ransom ER, Judy KD, Bigelow DC: Concurrent Cochlear Implantation with Resection of Skull Base Hemangiopericytoma following Sudden Deafness in an Only Hearing Ear. Skull Base; 2010 Jul;20(4):279-84
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  • A 72-year-old man with a known left acoustic neuroma, left-sided deafness, and a recently diagnosed right infratemporal fossa (ITF) hemangiopericytoma, presented with sudden deafness in his right ear.
  • Imaging revealed right-sided skull base extension and a large intracranial tumor component.
  • Complete tumor resection was possible, though invasion of the otic capsule was present.
  • Postoperative imaging confirmed complete tumor resection (Simpson grade I) and adequate CI placement.
  • Follow-up magnetic resonance imaging was performed at 6 and 12 months, and no tumor recurrence was seen.
  • Following adjuvant radiation, our patient remains disease free at 18 months.

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  • (PMID = 21311622.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3023313
  • [Keywords] NOTNLM ; Hemangiopericytoma / cochlear implant / infratemporal fossa / skull base tumor / sudden hearing loss
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54. Mathai KI, Sengupta SK, Shashivadhanan, Khanna V, Sudumbrekar SM, Sahoo PK: Hearing Preservation in a Case of Acoustic Schwannoma. Med J Armed Forces India; 2009 Jul;65(3):290-1
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  • [Title] Hearing Preservation in a Case of Acoustic Schwannoma.

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  • (PMID = 27408274.001).
  • [ISSN] 0377-1237
  • [Journal-full-title] Medical journal, Armed Forces India
  • [ISO-abbreviation] Med J Armed Forces India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC4921402
  • [Keywords] NOTNLM ; Acoustic schwannoma / Hearing conservation
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55. Remenyi J, Marshall A, Enticott JC, Briggs RJ: The prognostic value of speech recognition scores at diagnosis of vestibular schwannoma. J Clin Neurosci; 2009 Nov;16(11):1460-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The prognostic value of speech recognition scores at diagnosis of vestibular schwannoma.
  • We aimed to assess whether speech recognition scores (SRS) are predictive of outcomes in patients with small vestibular schwannoma (VS) undergoing observation.
  • [MeSH-major] Memory Disorders / etiology. Neuroma, Acoustic / complications. Neuroma, Acoustic / diagnosis. Pattern Recognition, Physiological / physiology. Speech Perception / physiology
  • [MeSH-minor] Acoustic Stimulation / methods. Adult. Aged. Aged, 80 and over. Audiometry, Pure-Tone / methods. Chi-Square Distribution. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Predictive Value of Tests. Prognosis. Psychoacoustics

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  • (PMID = 19740662.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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56. Franco-Vidal V, Blanchet H, Liguoro D, Darrouzet V: [Side-to-end hypoglossal-facial nerve anastomosis with intratemporal facial nerve translocation. Long-term results and indications in 15 cases over 10 years]. Rev Laryngol Otol Rhinol (Bord); 2006;127(1-2):97-102
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  • [Title] [Side-to-end hypoglossal-facial nerve anastomosis with intratemporal facial nerve translocation. Long-term results and indications in 15 cases over 10 years].
  • [Transliterated title] L'anastomose hypoglosso-faciale latéro-terminale avec déroutement du nerf facial intrapétreux. Résultats à long terme et indications. Une expérience de 10 ans sur 15 cas.
  • OBJECTIVES: To describe functional results concerning facial and lingual mobility after side-to end hypoglossal facial nerve anastomosis.
  • MATERIAL AND METHODS: 15 patients were operated on between 1993 and 2002 (11 cases of facial nerve injury during vestibular schwannoma surgery, and 4 cases of brainstem stroke).
  • The less satisfactory results were observed when patients were managed late (>2 years after nerve section) and in case of brainstem stroke.
  • [MeSH-major] Facial Nerve / surgery. Facial Paralysis / surgery. Hypoglossal Nerve / surgery. Neuroma, Acoustic / surgery

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  • (PMID = 16886539.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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57. Furuta S, Takahashi S, Higano S, Hashimoto S: Prediction of the origin of intracanalicular neoplasms with high-resolution MR imaging. Neuroradiology; 2005 Sep;47(9):657-63
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  • For MR diagnosis, the origin of intracanalicular neoplasms was predicted according to the location of the tumor in the internal auditory canal (IAC) in two ways, i.e., determining (1) a single specific nerve of origin and (2) whether the tumor originated from the superior or inferior aspect of the IAC.
  • Surgery could determine the nerve of origin in 16 cases (14 inferior and 2 superior vestibular schwannomas), but it was indeterminate in 4.
  • Comparison between MR prediction and surgical results on a single nerve origin revealed exact agreement in five, but inconsistent in three.
  • Regarding whether the tumor was derived from superior or inferior aspect of the IAC, agreement was found in 10 of the 16 cases (62.5%).
  • Caloric test was abnormal in all patients examined but one with superior vestibular schwannoma.
  • 3DFT-MR imaging was not particularly useful in predicting a precise nerve of origin of intracanalicular neoplasms.
  • The prediction on whether the tumor originated in the superior or inferior aspect of the IAC was superior to caloric test, which might have clinical significance in treatment planning especially for hearing preservation surgery.
  • [MeSH-major] Cranial Nerve Neoplasms / pathology. Ear, Inner / pathology. Facial Nerve Diseases / pathology. Vestibulocochlear Nerve Diseases / pathology

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  • [Cites] AJNR Am J Neuroradiol. 1998 Jun-Jul;19(6):1155-61 [9672031.001]
  • [Cites] Acta Otolaryngol Suppl. 1991;487:30-5 [1843582.001]
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  • (PMID = 16172909.001).
  • [ISSN] 0028-3940
  • [Journal-full-title] Neuroradiology
  • [ISO-abbreviation] Neuroradiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
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58. Myrseth E, Pedersen PH, Møller P, Lund-Johansen M: Treatment of vestibular schwannomas. Why, when and how? Acta Neurochir (Wien); 2007;149(7):647-60; discussion 660
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  • [Title] Treatment of vestibular schwannomas. Why, when and how?
  • Sporadic vestibular schwannoma (VS) causes unilateral hearing loss, tinnitus, vertigo and unsteadiness.
  • The predominant clinical endpoints of VS treatment include tumour control, facial nerve function and hearing preservation.
  • [MeSH-major] Neuroma, Acoustic / surgery. Neurosurgical Procedures / standards. Postoperative Complications / etiology. Postoperative Complications / prevention & control. Radiosurgery / standards. Vestibular Nerve / surgery
  • [MeSH-minor] Facial Nerve Injuries / prevention & control. Humans. Quality of Life. Risk Assessment. Vestibulocochlear Nerve Diseases / prevention & control

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  • (PMID = 17558460.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Austria
  • [Number-of-references] 144
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59. Penido Nde O, Tangerina RP, Kosugi EM, Abreu CE, Vasco MB: Vestibular Schwannoma: spontaneous tumor involution. Braz J Otorhinolaryngol; 2007 Nov-Dec;73(6):867-71
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  • [Title] Vestibular Schwannoma: spontaneous tumor involution.
  • The natural history of Vestibular Schwannomas (VS) is yet not totally known, but most of them have the tendency to slow growth, sometimes without any kind of symptoms during the individuals entire time.
  • Considering tumors that grow, about 70% have grown less than 2mm an year.
  • Advanced radiological diagnosis, especially magnetic resonance imaging with gadolinium helps us diagnose small and less symptomatic tumors.
  • Treatment of choice still is complete tumor resection.
  • Surgical approaches have improved considerably and have helped preserve facial nerve function and hearing.
  • Considering VSs natural history, there is a possibility for conservative treatment for these tumors, because their growth in the first year after diagnosis predicts tumor growth behavior in the next years.
  • Surgery should be done in cases of tumor growth, patients desire or symptoms worsening.
  • Moreover, in terms of postoperative sequelae, there is no difference between patients who underwent surgery immediately after diagnosis and those who underwent initial conservative treatment for these tumors.
  • [MeSH-major] Neoplasm Regression, Spontaneous / pathology. Neuroma, Acoustic / pathology

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  • (PMID = 18278239.001).
  • [ISSN] 1808-8694
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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60. Mrugala MM, Batchelor TT, Plotkin SR: Peripheral and cranial nerve sheath tumors. Curr Opin Neurol; 2005 Oct;18(5):604-10
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  • [Title] Peripheral and cranial nerve sheath tumors.
  • PURPOSE OF REVIEW: The intention of the authors is to provide the reader with an overview of the recent advances in the diagnosis and treatment of nerve sheath tumors.
  • Vestibular schwannomas, neurogenetic syndromes such as schwannomatosis and multiple isolated neurofibromas, and malignant peripheral nerve sheath tumors are covered in this review.
  • RECENT FINDINGS: Over the last year, literature focusing on different management strategies for patients with vestibular schwannomas dominated the field.
  • New insights into the biology of peripheral nerve tumor development and growth, including expression of vascular endothelial growth factor by vestibular schwannomas and the role of Notch signaling in malignant transformation of benign neurofibromas have been described.
  • SUMMARY: Peripheral nerve tumors are classified according to the specific features of cellular differentiation.
  • The most common types include schwannoma and neurofibroma.
  • These tumors can occur sporadically or as manifestations of genetic syndromes such as neurofibromatosis types 1 and 2 or schwannomatosis.
  • The majority of peripheral nerve tumors are benign but malignant transformation does occur.
  • Metastatic tumors can also affect peripheral nerves.
  • Positron emission tomography is a useful technique in the presurgical differentiation between benign and malignant peripheral nerve sheath tumors.
  • [MeSH-major] Cranial Nerve Neoplasms. Nerve Sheath Neoplasms / diagnosis. Nerve Sheath Neoplasms / therapy. Peripheral Nervous System Neoplasms

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  • (PMID = 16155448.001).
  • [ISSN] 1350-7540
  • [Journal-full-title] Current opinion in neurology
  • [ISO-abbreviation] Curr. Opin. Neurol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 33
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61. Arts HA, Telian SA, El-Kashlan H, Thompson BG: Hearing preservation and facial nerve outcomes in vestibular schwannoma surgery: results using the middle cranial fossa approach. Otol Neurotol; 2006 Feb;27(2):234-41
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  • [Title] Hearing preservation and facial nerve outcomes in vestibular schwannoma surgery: results using the middle cranial fossa approach.
  • OBJECTIVE: To evaluate surgical results using the middle cranial fossa approach for hearing preservation vestibular schwannoma surgery.
  • PATIENTS: Seventy-three consecutive patients with vestibular schwannoma operated on using the middle cranial fossa approach between February 1999 and February 2005.
  • INTERVENTIONS: The tumors were removed via the middle cranial fossa approach with modifications to improve exposure.
  • Standard auditory brainstem and facial nerve monitoring were used.
  • MAIN OUTCOME MEASURES: Pre- and postoperative hearing measures and facial function, tumor size, and postoperative complications.
  • Hearing status was categorized into Classes A, B, C, and D as described by the American Academy of Otolaryngology-Head and Heck Surgery "Guidelines for the Evaluation of Hearing Preservation in Acoustic Neuroma, 1995."
  • Nineteen patients had tumors larger than 10 mm in greatest dimension and had Class A or B hearing preoperatively.
  • At 4 months or greater follow-up, facial nerve outcome were excellent in 96%: House-Brackmann Grade I in 61 (85%), Grade II in 8 (11%), and Grade III in 3 (4%).
  • CONCLUSION: By achieving excellent exposure and using meticulous microsurgical technique, it is possible to resect small vestibular schwannomas via the middle fossa approach, with preservation of hearing at excellent or preoperative levels in the majority of patients, with excellent or satisfactory facial nerve outcomes in 96% of patients.
  • [MeSH-major] Auditory Threshold / physiology. Facial Nerve / physiology. Facial Paralysis / prevention & control. Hearing Loss, Sensorineural / prevention & control. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods

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  • (PMID = 16436995.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Lustgarten L: Use of Bioglue in translabyrinthine vestibular schwannoma surgery. Otol Neurotol; 2007 Oct;28(7):992
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  • [Title] Use of Bioglue in translabyrinthine vestibular schwannoma surgery.
  • [MeSH-major] Bone Cements. Cranial Nerve Neoplasms / surgery. Neuroma, Acoustic / surgery. Otologic Surgical Procedures. Vestibulocochlear Nerve Diseases / surgery

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  • [CommentOn] Otol Neurotol. 2006 Jan;27(1):102-5 [16371855.001]
  • (PMID = 17909439.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Cements
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63. Jatana KR, Jacob A, Slone HW, Ray-Chaudhury A, Welling DB: Spinal myxopapillary ependymoma metastatic to bilateral internal auditory canals. Ann Otol Rhinol Laryngol; 2008 Feb;117(2):98-102
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  • The diagnosis of NF2 with bilateral vestibular schwannomas was entertained.
  • This finding raised the possibility of other, more unusual IAC lesions.
  • Although vestibular schwannomas account for the majority of contrast-enhancing T1-weighted IAC lesions, other uncommon lesions may present in a similar manner.
  • Therefore, both T1-weighted MRI with or without contrast and T2-weighted MRI may be necessary to distinguish vestibular schwannoma from other, more unusual IAC lesions.

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  • (PMID = 18357830.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Pitchford CW, Schwartz HS, Atkinson JB, Cates JM: Soft tissue perineurioma in a patient with neurofibromatosis type 2: a tumor not previously associated with the NF2 syndrome. Am J Surg Pathol; 2006 Dec;30(12):1624-9
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  • [Title] Soft tissue perineurioma in a patient with neurofibromatosis type 2: a tumor not previously associated with the NF2 syndrome.
  • Neoplasms that commonly affect patients with neurofibromatosis type 2 (NF2) include schwannomas, meningiomas, astrocytomas, ependymomas, and neurofibromas.
  • Perineuriomas are rare tumors of the peripheral nerve sheath that share some characteristics with meningioma.
  • As in both NF2-associated and sporadic cases of schwannoma and meningioma, perineuriomas often harbor mutations or deletions of the NF2 gene.
  • A 30-year-old man with a history of bilateral vestibular schwannomas, a parasagittal meningioma, an intraspinal ependymoma, and multiple other neoplasms involving both cranial and peripheral nerves (thereby fulfilling the diagnostic criteria for NF2) presented with an enlarging thigh mass.
  • [MeSH-major] Nerve Sheath Neoplasms / complications. Neurofibromatosis 2 / complications. Soft Tissue Neoplasms / complications
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Cytoplasm / ultrastructure. Diagnosis, Differential. Humans. Male. Neoplasms, Multiple Primary. Peripheral Nervous System Neoplasms / diagnosis

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  • (PMID = 17122521.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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65. Baser ME, Contributors to the International NF2 Mutation Database: The distribution of constitutional and somatic mutations in the neurofibromatosis 2 gene. Hum Mutat; 2006 Apr;27(4):297-306
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  • Constitutional heterozygous inactivating mutations in the neurofibromatosis 2 (NF2) tumor suppressor gene cause the autosomal dominant disease NF2, and biallelic inactivating somatic NF2 mutations are found in a high proportion of unilateral sporadic vestibular schwannoma (USVS) and sporadic meningioma.


66. Schüz J, Johansen C: A comparison of self-reported cellular telephone use with subscriber data: agreement between the two methods and implications for risk estimation. Bioelectromagnetics; 2007 Feb;28(2):130-6
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  • In Denmark, we conducted a retrospective cohort study of cellular telephone subscribers (including the entire Danish population) and a case-control study on brain tumors and cellular telephone use (with 1355 participants) and, thus, had the opportunity to compare the two exposure measures with two large-scale data sets, using self-reported use as a "gold standard."
  • A comparison of odds ratios (OR) of the case-control data set based on either self-reported use or on subscriber data shows no major differences, giving OR of 0.7 and 0.6 for acoustic neuroma, 0.9 and 1.1 for glioma and 0.9 and 0.7 for meningioma.
  • [MeSH-minor] Cell Phones. Denmark. Environmental Exposure. Humans. Reproducibility of Results. Retrospective Studies. Risk Assessment. Time Factors

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  • (PMID = 17019732.001).
  • [ISSN] 0197-8462
  • [Journal-full-title] Bioelectromagnetics
  • [ISO-abbreviation] Bioelectromagnetics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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67. Akamatsu Y, Murakami K, Watanabe M, Jokura H, Tominaga T: Malignant peripheral nerve sheath tumor arising from benign vestibular schwannoma treated by gamma knife radiosurgery after two previous surgeries: a case report with surgical and pathological observations. World Neurosurg; 2010 Jun;73(6):751-4
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  • [Title] Malignant peripheral nerve sheath tumor arising from benign vestibular schwannoma treated by gamma knife radiosurgery after two previous surgeries: a case report with surgical and pathological observations.
  • BACKGROUND: Gamma knife radiosurgery (GKRS) is an effective treatment for vestibular schwannomas with lower morbidity and mortality.
  • METHODS: We describe a case presenting with malignant peripheral nerve sheath tumor (MPNST) at 8 years after GKRS after incomplete resections.
  • RESULTS: The tumor appeared to be a typical benign schwannoma at the surgery preceding GKRS, and rapidly enlarged after long-term control, causing progressive neurological deterioration.
  • Operative findings showed that the tumor was composed of two different components, and histopathology distinctively demonstrated MPNST and benign schwannoma.
  • CONCLUSIONS: The coexistence of benign and malignant components might indicate that the present MPNST had arisen from the benign schwannoma by transformation in association with GKRS.
  • [MeSH-major] Mixed Tumor, Malignant / etiology. Mixed Tumor, Malignant / pathology. Neoplasms, Radiation-Induced / pathology. Nerve Sheath Neoplasms / etiology. Nerve Sheath Neoplasms / pathology. Neuroma, Acoustic / surgery. Radiosurgery / adverse effects
  • [MeSH-minor] Aged. Cell Transformation, Neoplastic / pathology. Cell Transformation, Neoplastic / radiation effects. Female. Humans. Neurosurgical Procedures / methods. Radiation Injuries / diagnosis. Radiation Injuries / pathology. Reoperation / methods. Treatment Failure. Treatment Outcome. Vestibular Nerve / pathology. Vestibular Nerve / radiation effects. Vestibular Nerve / surgery


68. Saman Y, Bamiou DE, Gleeson M: A contemporary review of balance dysfunction following vestibular schwannoma surgery. Laryngoscope; 2009 Nov;119(11):2085-93
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  • [Title] A contemporary review of balance dysfunction following vestibular schwannoma surgery.
  • OBJECTIVES/HYPOTHESIS: This review aims to evaluate the literature pertaining to subjective balance dysfunction following vestibular schwannoma surgery; the effect of postoperative imbalance on disability, handicap and quality of life; and to determine factors that influence vestibular compensation.
  • METHODS: Ovid MEDLINE, Cochrane databases, and relevant contemporary texts were searched for papers relating to subjective balance dysfunction following vestibular schwannoma surgery.
  • RESULTS: The search yielded 26 studies assessing subjective balance dysfunction following vestibular schwannoma surgery.
  • CONCLUSIONS: Further study is needed of the factors that influence vestibular compensation following vestibular schwannoma surgery.
  • [MeSH-major] Neuroma, Acoustic / surgery. Postoperative Complications. Postural Balance. Sensation Disorders

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  • (PMID = 19806649.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 47
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69. Bluhm EC, Zahm SH, Fine HA, Black PM, Loeffler JS, Shapiro WR, Selker RG, Inskip PD: Personal hair dye use and risks of glioma, meningioma, and acoustic neuroma among adults. Am J Epidemiol; 2007 Jan 1;165(1):63-71
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  • [Title] Personal hair dye use and risks of glioma, meningioma, and acoustic neuroma among adults.
  • Risks for brain tumors are not well understood.
  • The authors investigated associations between use of synthetic hair dyes and risk of brain tumors in a hospital-based case-control study.
  • The study included adults newly diagnosed with glioma (n = 489), meningioma (n = 197), or acoustic neuroma (n = 96) between 1994 and 1998 at three urban US hospitals and 799 controls.
  • There was no consistent pattern of elevated odds ratios for glioma, meningioma, or acoustic neuroma with use or prolonged use of permanent, semipermanent, temporary, or gradual hair dyes.
  • Although use of permanent brown hair dye for 20 or more years was associated with glioma among women, the estimate was imprecise (odds ratio = 3.8, 95% confidence interval: 1.2, 12.5) and was based on just 13 exposed cases; thus, this could be a chance finding.
  • Overall, there was little consistent evidence for an association of synthetic hair dye use with glioma, meningioma, or acoustic neuroma.
  • [MeSH-major] Brain Neoplasms / epidemiology. Environmental Exposure / adverse effects. Glioma / epidemiology. Hair Dyes / toxicity. Meningioma / epidemiology. Neuroma, Acoustic / epidemiology


70. Timmer FC, van Haren AE, Mulder JJ, Hanssens PE, van Overbeeke JJ, Cremers CW, Graamans K: Quality of life after gamma knife radiosurgery treatment in patients with a vestibular schwannoma: the patient's perspective. Eur Arch Otorhinolaryngol; 2010 Jun;267(6):867-73
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  • [Title] Quality of life after gamma knife radiosurgery treatment in patients with a vestibular schwannoma: the patient's perspective.
  • This study evaluates the impact of gamma knife radiosurgery (GKRS) on the quality of life (QOL) of patients with a sporadic vestibular schwannoma (VS).
  • Their mean tumor size was 17 mm (range 6-39 mm); the mean maximum dose on the tumor was 19.9 Gy (range 16-25.5 Gy) and the mean marginal dose on the tumor was 11.1 (range 9.3-12.5 Gy).
  • No correlation was found between QOL and gender, age, tumor size, or radiation dose.
  • No predictive patient, tumor, or treatment factors for QOL outcome after GKRS could be determined.
  • [MeSH-major] Neuroma, Acoustic / psychology. Neuroma, Acoustic / surgery. Patient Satisfaction. Quality of Life / psychology. Radiosurgery / psychology

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  • (PMID = 19894058.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2857884
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71. Ahmad M, Butt RM, Ahmad N: Jugular foramen schwannoma--a very rare entity. J Ayub Med Coll Abbottabad; 2009 Apr-Jun;21(2):174-5
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  • [Title] Jugular foramen schwannoma--a very rare entity.
  • Jugular foramen schwannoma is a very rare tumour and very few cases have been reported in the literature.
  • Usually it is misdiagnosed as acoustic neuroma and the diagnosis is made peroperatively.
  • We present a case of jugular foramen schwannoma who was operated by the senior author.
  • [MeSH-major] Glomus Jugulare Tumor / surgery. Head and Neck Neoplasms / surgery. Jugular Veins. Neurilemmoma / surgery. Vascular Neoplasms / surgery

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  • (PMID = 20524500.001).
  • [ISSN] 1025-9589
  • [Journal-full-title] Journal of Ayub Medical College, Abbottabad : JAMC
  • [ISO-abbreviation] J Ayub Med Coll Abbottabad
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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72. Stangerup SE, Tos M, Thomsen J, Caye-Thomasen P: True incidence of vestibular schwannoma? Neurosurgery; 2010 Nov;67(5):1335-40; discussion 1340
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  • [Title] True incidence of vestibular schwannoma?
  • BACKGROUND: The incidence of diagnosed sporadic unilateral vestibular schwannomas (VS) has increased, due primarily to more widespread access to magnetic resonance imaging.
  • OBJECTIVE: To present updated epidemiological data on VS incidence, as well as patient age, hearing acuity, tumor size, and localization at diagnosis for the last 4 decades in an unselected population, with emphasis on developments in recent years.
  • Incidence during the period, patient sex and age, data on hearing (pure tone average and speech discrimination), and tumor size at diagnosis were retrieved from the database.
  • Mean tumor size at diagnosis decreased from 30 mm in 1979 to 10 mm in 2008, whereas hearing acuity at diagnosis has improved over the years.
  • CONCLUSION: After a steady increase over the last 4 decades, the incidence of vestibular schwannomas appears to have peaked and decreased in recent years, stabilizing at about 19 tumors per million per year.
  • Whereas the sex ratio and age at diagnosis have remained grossly unchanged over the years, hearing has improved, and tumor size has decreased considerably.
  • [MeSH-major] Neuroma, Acoustic / epidemiology

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  • (PMID = 20871439.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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73. Somefun OA, Giwa OS, Bamgboye BA, Okeke-Igbokwe II, Azeez AA: Vestibular disorders among adults in a tertiary hospital in Lagos, Nigeria. Eur Arch Otorhinolaryngol; 2010 Oct;267(10):1515-21
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  • [Title] Vestibular disorders among adults in a tertiary hospital in Lagos, Nigeria.
  • The objective of this study was to document the evaluation, causes and treatment of vestibular disorders among our patients.
  • X-ray of the cervical spine and computerized tomogram scan of internal auditory meatus and brain when indicated were done.
  • Clinical signs on neuro-otological examination were elicited on 39 (38.2%) of the patients while on VNG the vestibular subtest mainly caloric test was abnormal unilaterally and bilaterally in 47 (46.1%) while with the oculomotor subtests, smooth pursuit tests were abnormal in 5 (6.9%), saccade tests were abnormal in 8 (7.8%) and OPK were abnormal in 9 (8.8%).
  • Peripheral vestibular disorders are common of which benign paroxysmal positional vertigo (BPPV) was seen in 29 (28.4%), Meniere's disease in 22 (21.6%), recurrent vestibulopathy in 20 (19.6%), cervical vertigo in 18 (17.6%), psychogenic vertigo in 2 (2%), vestibular schwannoma, barotraumas and drug-induced vertigo in 1 (1%), respectively, central vestibular disorders of vascular origin 2 (2%), vertebrobasilar insufficiency in 1 (1%), post-traumatic vertigo in 3 (3%) and unknown in 2 (2%).
  • In conclusion, peripheral vestibular disorders are common of which BPPV is the most prevalent.
  • [MeSH-major] Vestibular Diseases / diagnosis. Vestibular Diseases / epidemiology

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  • (PMID = 20464409.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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74. Beegle RD, Friedman WA, Bova FJ: Effect of treatment plan quality on outcomes after radiosurgery for vestibular schwannoma. J Neurosurg; 2007 Nov;107(5):913-6
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  • [Title] Effect of treatment plan quality on outcomes after radiosurgery for vestibular schwannoma.
  • OBJECT: The goal in this study was to review the effects of treatment plan quality on outcomes after radiosurgery for vestibular schwannoma (VS).
  • Multivariate statistics were used to determine the effects of these variables on tumor control and on two types of complication, facial weakness and facial numbness.
  • RESULTS: The 5-year actuarial tumor control was 91%.
  • Dosimetry had no effect on tumor control.
  • In this model, prior tumor growth was also significant.
  • [MeSH-major] Neuroma, Acoustic / surgery. Patient Care Planning / standards. Radiosurgery / methods
  • [MeSH-minor] Facial Nerve Diseases / etiology. Humans. Postoperative Complications. Radiometry

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  • (PMID = 17977260.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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75. Rohit, Piccirillo E, Jain Y, Augurio A, Sanna M: Preoperative predictive factors for hearing preservation in vestibular schwannoma surgery. Ann Otol Rhinol Laryngol; 2006 Jan;115(1):41-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Preoperative predictive factors for hearing preservation in vestibular schwannoma surgery.
  • OBJECTIVES: We performed a retrospective chart review to evaluate the various predictive factors for postoperative hearing preservation in the surgical management of vestibular schwannoma.
  • METHODS: Of 792 patients operated on for vestibular schwannoma between April 1987 and July 2002, 107 were candidates for hearing preservation surgery.
  • These patients were divided into group 1 (hearing preserved) and group 2 (hearing not preserved), and both of these groups were evaluated for age, sex, pure tone average, sound discrimination score, tumor size, and auditory brain stem response parameters.
  • RESULTS: Preoperative pure tone average and tumor size were the 2 predictive factors in our study.
  • On multiple regression analysis by backward elimination of nonsignificant factors, we found that tumor size is an independent predictive factor for postoperative hearing.
  • CONCLUSIONS: In our series, preoperative pure tone average and tumor size were found to be predictors of postoperative hearing levels.
  • [MeSH-major] Hearing / physiology. Hearing Loss / prevention & control. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods

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  • (PMID = 16466099.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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76. Stern RL, Perks JR, Pappas CT, Boggan JE, Chen AY: The option of Linac-based radiosurgery in a Gamma Knife radiosurgery center. Clin Neurol Neurosurg; 2008 Dec;110(10):968-72
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  • OBJECTIVE: Due to the fundamental differences in treatment delivery, linear-accelerator-based radiosurgery can be complementary to Gamma Knife (GK) for intracranial lesions.
  • Besides a major increase for trigeminal neuralgia and a general growth for acoustic neuroma, meningioma and brain metastases, case numbers for glioma and arteriovenous malformation (AVM) remained stable.
  • [MeSH-major] Brain Neoplasms / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Radiosurgery / methods
  • [MeSH-minor] California. Follow-Up Studies. Humans. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Oncology Service, Hospital / organization & administration. Particle Accelerators. Radiation Oncology / organization & administration. Radiotherapy Planning, Computer-Assisted / methods. Radiotherapy, Intensity-Modulated / methods. Surgery Department, Hospital / organization & administration. Treatment Outcome. Trigeminal Neuralgia / pathology. Trigeminal Neuralgia / surgery

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  • (PMID = 18617321.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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77. Liu JK, Sayama CM, Shelton C, MacDonald JD: Transient facial nerve palsy after topical papaverine application during vestibular schwannoma surgery. Case report. J Neurosurg; 2007 Nov;107(5):1039-42
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  • [Title] Transient facial nerve palsy after topical papaverine application during vestibular schwannoma surgery. Case report.
  • Some evidence in the literature supports the topical application of papaverine to the cochlear nerve to prevent internal auditory artery vasospasm and cochlear ischemia as a method of enhancing the ability to preserve hearing during acoustic neuroma surgery.
  • The authors report a case of transient facial nerve palsy that occurred after papaverine was topically applied during a hearing preservation acoustic neuroma removal.
  • Magnetic resonance imaging demonstrated a 1.5-cm acoustic neuroma in the right cerebellopontine angle (CPA).
  • A retrosigmoid approach was performed to achieve gross-total resection of the tumor.
  • During tumor removal, a solution of 3% papaverine soaked in a Gelfoam pledget was placed over the cochlear nerve.
  • Shortly thereafter, the quality of the facial nerve stimulation deteriorated markedly.
  • Electrical stimulation of the facial nerve did not elicit a response at the level of the brainstem but was observed to elicit a robust response more peripherally.
  • At the 1-month follow-up examination, the patient exhibited normal facial nerve function and stable hearing.
  • Intracisternal papaverine may cause a transient facial nerve palsy by producing a temporary conduction block of the facial nerve.
  • [MeSH-major] Facial Paralysis / chemically induced. Neuroma, Acoustic / surgery. Papaverine / adverse effects. Vasodilator Agents / adverse effects

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  • (PMID = 17977279.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vasodilator Agents; DAA13NKG2Q / Papaverine
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78. Tong MC, Lam JM, Hu BH, Sanna M: [Clinical experience in 36 cases of using of the extended translabyrinthine technique for the treatment of large acoustic neuromas]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2005 Sep;40(9):705-7
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  • [Title] [Clinical experience in 36 cases of using of the extended translabyrinthine technique for the treatment of large acoustic neuromas].
  • [MeSH-major] Fenestration, Labyrinth / methods. Neuroma, Acoustic / surgery

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  • (PMID = 16335411.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Journal Article
  • [Publication-country] China
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79. Inoue HK: Low-dose radiosurgery for large vestibular schwannomas: long-term results of functional preservation. J Neurosurg; 2005 Jan;102 Suppl:111-3
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  • [Title] Low-dose radiosurgery for large vestibular schwannomas: long-term results of functional preservation.
  • OBJECT: The author conducted a study to assess the long-term results obtained in patients who underwent GKS for large vestibular schwannomas (> 3 cm in diameter).
  • Facial and cochlear nerve functions were evaluated.
  • METHODS: Twenty consecutive large tumors in 18 patients (including two cases of neurofibromatosus Type 2 [NF2]) were followed for more than 6 years.
  • There were eight tumors that were more than 4 cm in maximum diameter.
  • Microsurgery had already been performed prior to GKS in 11 patients (nine recurrent and two residual tumors).
  • Fourteen of 15 tumors were stable or decreased in size.
  • Facial nerve function was preserved in all patients and hearing preserved in four of five patients with cochlear nerve function prior to radiosurgery.
  • CONCLUSIONS: Gamma knife surgery seems to have a place in the low-dose treatment of selected large vestibular schwannoma in patients with a reasonable chance of retaining facial function and pretreatment hearing level.
  • [MeSH-major] Facial Nerve / physiology. Neuroma, Acoustic / surgery. Radiosurgery / instrumentation
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cochlear Nerve / physiopathology. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Microsurgery / instrumentation. Middle Aged. Neoplasm Recurrence, Local. Neurofibromatosis 2 / pathology. Neurofibromatosis 2 / surgery. Radiation Dosage. Time Factors

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  • (PMID = 15662791.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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80. Kambe A, Kamitani H, Watanabe T, Oka A, Inagaki H, Ishii T, Ueki K: A non-NF2 case of schwannomas of vestibular and trigeminal nerves with different genetic alterations of NF2 gene: case report. Surg Neurol; 2005 Jan;63(1):62-4; discussion 64-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A non-NF2 case of schwannomas of vestibular and trigeminal nerves with different genetic alterations of NF2 gene: case report.
  • BACKGROUND: We report a patient with 2 separate schwannomas, a vestibular schwannoma and a trigeminal schwannoma, that were attached to each other and appeared to be a single tumor on imaging studies.
  • CASE DESCRIPTION: The patient, without any family history of neurofibromatosis, presented with a progressive hearing loss and mild left facial nerve palsy.
  • Magnetic resonance imaging showed a snowman-like tumor in the left cerebellopontine angle.
  • Surgical exposure revealed that the tumor consisted of 2 "kissing" schwannomas, a trigeminal and vestibular schwannoma.
  • Molecular genetic analysis detected a 1-base pair deletion at exon 10 of the neurofibromatosis type 2 (NF2) gene in the trigeminal schwannoma, but not in the acoustic schwannoma.
  • However, loss of heterozygosity at chromosome 22q (D22S282 and D22S929) was detected in both tumors, losing the same allele.
  • CONCLUSION: Multiple schwannomas in non-NF2 patients are extremely rare, and possible causes include simple coincidence or germline genetic alteration of adjacent gene on chromosome 22q, similar to the cause recently suggested in familial schwannomatosis.
  • [MeSH-major] Genes, Neurofibromatosis 2. Neuroma, Acoustic / genetics. Trigeminal Nerve / pathology. Trigeminal Nerve Diseases / genetics. Vestibular Nerve / pathology
  • [MeSH-minor] Chromosomes, Human, Pair 22 / genetics. Craniotomy. DNA Mutational Analysis. Decompression, Surgical. Facial Nerve Diseases / etiology. Facial Nerve Diseases / pathology. Facial Nerve Diseases / physiopathology. Gene Deletion. Hearing Loss / etiology. Hearing Loss / pathology. Hearing Loss / physiopathology. Humans. Loss of Heterozygosity / genetics. Magnetic Resonance Imaging. Male. Middle Aged. Treatment Outcome

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  • (PMID = 15639530.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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81. Raftopoulos C, Abu Serieh B, Duprez T, Docquier MA, Guérit JM: Microsurgical results with large vestibular schwannomas with preservation of facial and cochlear nerve function as the primary aim. Acta Neurochir (Wien); 2005 Jul;147(7):697-706; discussion 706
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  • [Title] Microsurgical results with large vestibular schwannomas with preservation of facial and cochlear nerve function as the primary aim.
  • OBJECTIVE: To evaluate our microsurgical results in dealing with vestibular schwannomas (VS) greater than or equal to 30 mm when preservation of cranial nerve function was considered more important than total tumour removal.
  • METHODS: Sixteen consecutive cases were operated on by the same neurosurgeon according to a prospective protocol using intraoperative neuro-monitoring (IONM) based on electromyographic and brain stem auditory evoked potential recordings.
  • Facial nerve function was evaluated on the House-Brackmann Scale and cochlear nerve function on the Gardner-Robertson Scale.
  • RESULTS: Fifteen patients showed facial nerve (FN) function of House-Brackmann grade (HBG) I or II at one year postoperatively and one kept the HBG IV she had preoperatively.
  • Two patients of four maintained a cochlear nerve function of Gardner-Robertson grade (GRG) II.
  • CONCLUSION: When dealing with VS greater than or equal to 30 mm, microsurgery guided by IONM, with a rate of total or near-total tumour excision of about 75%, can retain socially acceptable facial nerve function (HBG I or II) in all cases and serviceable hearing (GRG I or II) in two cases out of four.
  • Maintaining serviceable cranial nerve function should take precedence over total tumour excision.
  • [MeSH-major] Electromyography. Evoked Potentials, Auditory, Brain Stem / physiology. Microsurgery. Monitoring, Intraoperative. Neuroma, Acoustic / surgery. Postoperative Complications / physiopathology
  • [MeSH-minor] Adult. Aged. Brain Stem / physiopathology. Child. Cochlear Nerve / physiopathology. Facial Nerve / physiopathology. Female. Follow-Up Studies. Humans. Infant. Magnetic Resonance Imaging. Male. Middle Aged. Neurologic Examination. Prospective Studies

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  • (PMID = 15900399.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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82. Francesco F, Maurizio I, Stefano C, Marina S, Ugo S, Massimo S: Trigeminal nerve root entry zone pilocytic astrocytoma in an adult: a rare case of an extraparenchymal tumor. J Neurooncol; 2010 Apr;97(2):285-90
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  • [Title] Trigeminal nerve root entry zone pilocytic astrocytoma in an adult: a rare case of an extraparenchymal tumor.
  • Extra-axial cerebellopontine angle (CPA) tumors account for approximately 10% of all brain neoplasms in adults.
  • Vestibular schwannomas are the most common, followed by meningiomas.
  • Gliomas in the CPA are rare and quite often are the exophytic extension of primary brain stem or cerebellar tumors.
  • We describe a pilocytic astrocytoma of the CPA that was found to arise from the proximal portion of trigeminal nerve without any anatomic continuity with the brain stem and the cerebellum.
  • Pre-operative MRI suggested a schwannoma.
  • The proposed origin of this extremely rare tumor is the root entry zone of the involved nerve.
  • The tumor was completely resected via a suboccipital retrosigmoid approach.
  • [MeSH-major] Astrocytoma / pathology. Cerebellar Neoplasms / pathology. Cerebellopontine Angle / pathology. Cranial Nerve Neoplasms / pathology. Trigeminal Nerve Diseases / pathology

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  • [Cites] Arch Otolaryngol. 1980 Aug;106(8):456-9 [7396789.001]
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  • (PMID = 19820900.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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83. Lassaletta L, Alfonso C, Del Rio L, Roda JM, Gavilan J: Impact of facial dysfunction on quality of life after vestibular schwannoma surgery. Ann Otol Rhinol Laryngol; 2006 Sep;115(9):694-8
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  • [Title] Impact of facial dysfunction on quality of life after vestibular schwannoma surgery.
  • OBJECTIVES: This study was performed to evaluate the impact of facial dysfunction on quality of life in patients who underwent surgery for vestibular schwannoma.
  • METHODS: We performed a retrospective review of 95 patients who underwent removal of a unilateral vestibular schwannoma.
  • CONCLUSIONS: An overestimation of the effect of facial paralysis after vestibular schwannoma resection may exist on the surgeon's part.
  • Detailed information about the possibility of hearing loss, vestibular problems, and pain must be given to all patients.
  • [MeSH-major] Facial Paralysis / psychology. Neuroma, Acoustic / surgery. Quality of Life

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  • (PMID = 17044542.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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84. Halefoğlu AM: Neurofibromatosis type 2 associated with multiple cranial nerve schwannomas: a case report. Kulak Burun Bogaz Ihtis Derg; 2007;17(3):171-5
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  • [Title] Neurofibromatosis type 2 associated with multiple cranial nerve schwannomas: a case report.
  • He also had a family history of neurofibromatosis type 2 and a history of a prior operation for left vestibular schwannoma a year ago.
  • Magnetic resonance imaging demonstrated multiple extra-axial enhancing masses in the vicinity of both hypoglossal nerves, the right vestibular nerve, the left vestibular nerve, the right trigeminal, the left occulomotor, and the right abducens nerves.
  • These findings were evaluated as multiple cranial nerve schwannomas.
  • [MeSH-major] Cochlear Nerve. Cranial Nerve Neoplasms / diagnosis. Neurilemmoma / diagnosis. Neurofibromatosis 2 / diagnosis

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  • (PMID = 17873509.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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85. Akhmametyeva EM, Mihaylova MM, Luo H, Kharzai S, Welling DB, Chang LS: Regulation of the neurofibromatosis 2 gene promoter expression during embryonic development. Dev Dyn; 2006 Oct;235(10):2771-85
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  • Mutations in the Neurofibromatosis 2 (NF2) gene are associated with predisposition to vestibular schwannomas, spinal schwannomas, meningiomas, and ependymomas.
  • Importantly, we observed strong NF2 promoter activity in the developing brain and in sites containing migrating cells including the neural tube closure, branchial arches, dorsal aorta, and paraaortic splanchnopleura.
  • Furthermore, we noted a transient change of NF2 promoter activity during neural crest cell migration.
  • In addition, we detected considerable NF2 promoter activity in various NF2-affected tissues such as acoustic ganglion, trigeminal ganglion, spinal ganglia, optic chiasma, the ependymal cell-containing tela choroidea, and the pigmented epithelium of the retina.
  • The NF2 promoter expression pattern during embryogenesis suggests a specific regulation of the NF2 gene during neural crest cell migration and further supports the role of merlin in cell adhesion, motility, and proliferation during development.
  • [MeSH-minor] Animals. Cell Movement / genetics. Cell Movement / physiology. DNA, Complementary / genetics. Ectoderm / metabolism. Female. Ganglia / embryology. Ganglia / metabolism. Humans. Immunohistochemistry. In Situ Hybridization / methods. Male. Mice. Mice, Transgenic. Nervous System / embryology. Nervous System / metabolism. Neural Crest / embryology. Neural Crest / metabolism. Pregnancy. Recombinant Fusion Proteins / genetics. Recombinant Fusion Proteins / metabolism. beta-Galactosidase / genetics. beta-Galactosidase / metabolism

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16894610.001).
  • [ISSN] 1058-8388
  • [Journal-full-title] Developmental dynamics : an official publication of the American Association of Anatomists
  • [ISO-abbreviation] Dev. Dyn.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA16058
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / Neurofibromin 2; 0 / Recombinant Fusion Proteins; EC 3.2.1.23 / beta-Galactosidase
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86. O'Malley MR, Haynes DS: Assessment and management of meningitis following cerebellopontine angle surgery. Curr Opin Otolaryngol Head Neck Surg; 2008 Oct;16(5):427-33
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  • Mortality from postoperative bacterial meningitis is rare in patients undergoing resection of an acoustic neuroma.
  • [MeSH-major] Cerebellopontine Angle / surgery. Meningitis, Aseptic / drug therapy. Meningitis, Bacterial / drug therapy. Neuroma, Acoustic / surgery. Neurosurgical Procedures / adverse effects

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  • (PMID = 18797284.001).
  • [ISSN] 1531-6998
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Steroids
  • [Number-of-references] 85
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87. Saito DM, Cheung SW: A comparison of facial nerve disability between patients with Bell's palsy and vestibular schwannoma. J Clin Neurosci; 2010 Sep;17(9):1122-5
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  • [Title] A comparison of facial nerve disability between patients with Bell's palsy and vestibular schwannoma.
  • We compared self-assessed morbidity of facial nerve dysfunction arising from surgical intervention with those in non-surgical clinical scenarios in a cross-sectional observational study.
  • The validated patient-graded Facial Clinimetric Evaluation (FaCE) scale and a supplementary questionnaire were mailed to adult subjects with a history of facial nerve dysfunction.
  • Seventy-five completed survey packets were returned: 53 (71%) cases of facial nerve dysfunction were caused by surgery for vestibular schwannoma and 22 (29%) were the result of Bell's palsy.
  • The vestibular schwannoma cohort reported less paralysis-related morbidity in the subscale domains of facial movement and social function (p < 0.03, one-way analysis of variance [ANOVA]).
  • We concluded that patients with facial nerve dysfunction arising from surgical intervention experienced less morbidity than those caused by non-surgical etiologies.
  • [MeSH-major] Bell Palsy / physiopathology. Facial Paralysis / physiopathology. Neuroma, Acoustic / physiopathology. Postoperative Complications / physiopathology
  • [MeSH-minor] Adult. Aged. Cohort Studies. Cross-Sectional Studies. Facial Nerve / physiopathology. Facial Nerve / surgery. Female. Humans. Male. Middle Aged


88. Friedman WA, Bradshaw P, Myers A, Bova FJ: Linear accelerator radiosurgery for vestibular schwannomas. J Neurosurg; 2006 Nov;105(5):657-61
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  • [Title] Linear accelerator radiosurgery for vestibular schwannomas.
  • OBJECT: Radiosurgery has become a popular treatment for small vestibular schwannomas (VSs).
  • Multivariate and actuarial statistics were used to analyze rates of local tumor control and complications, including facial and trigeminal neuropathies, after treatment.
  • Only four patients (1%) required surgery for tumor growth.
  • The risk of these complications rose with increasing tumor volume or increasing radiosurgical dose to the tumor periphery.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery

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  • [CommentIn] J Neurosurg. 2006 Nov;105(5):655-6; discussion 656 [17121122.001]
  • (PMID = 17121123.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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89. Pollock BE, Link MJ, Foote RL: Failure rate of contemporary low-dose radiosurgical technique for vestibular schwannoma. J Neurosurg; 2009 Oct;111(4):840-4
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  • [Title] Failure rate of contemporary low-dose radiosurgical technique for vestibular schwannoma.
  • OBJECT: The decline in cranial nerve morbidity after radiosurgery for vestibular schwannoma (VS) correlates with dose reduction and other technical changes to this procedure.
  • The effect these changes have had on tumor control has not been well documented.
  • The median radiation dose to the tumor margin was 13 Gy.
  • Treatment failure was defined as progressive tumor enlargement noted on 2 or more imaging studies.
  • RESULTS: Tumor growth was noted in 15 patients (5%) at a median of 32 months after radiosurgery.
  • Radiographically demonstrated tumor control was 96% at 3 years and 94% at 7 years after radiosurgery.
  • Univariate analysis revealed 2 factors that correlated with failed radiosurgery for VS: an increasing number of isocenters (p = 0.03) and tumor margin radiation doses <or= 13 Gy (p = 0.02).
  • The tumor margin radiation dose (p = 0.22) was not associated with tumor growth after radiosurgery.
  • CONCLUSIONS: Distortion of stereotactic MR imaging coupled with increased radiosurgical conformality and progressive dose reduction likely caused some VSs to receive less than the prescribed radiation dose to the entire tumor volume.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / methods

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  • (PMID = 19408975.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Shelfer J, Zapala D, Lundy L: Fall risk, vestibular schwannoma, and anticoagulation therapy. J Am Acad Audiol; 2008 Mar;19(3):237-45
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  • [Title] Fall risk, vestibular schwannoma, and anticoagulation therapy.
  • A case is presented of an 87-year-old female with balance problems, in part from a small unilateral vestibular schwannoma.
  • [MeSH-major] Accidental Falls. Anticoagulants / adverse effects. Neuroma, Acoustic / diagnosis. Warfarin / adverse effects

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  • (PMID = 18672652.001).
  • [ISSN] 1050-0545
  • [Journal-full-title] Journal of the American Academy of Audiology
  • [ISO-abbreviation] J Am Acad Audiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Anticoagulants; 5Q7ZVV76EI / Warfarin
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91. Propp JM, McCarthy BJ, Davis FG, Preston-Martin S: Descriptive epidemiology of vestibular schwannomas. Neuro Oncol; 2006 Jan;8(1):1-11
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  • [Title] Descriptive epidemiology of vestibular schwannomas.
  • Vestibular schwannomas, commonly termed acoustic neuromas, arise from the vestibular branch of the eighth cranial nerve (acoustic nerve) and are benign, slow-growing brain tumors that negatively impact patient quality of life.
  • They are thought to account for the majority of intracranial nerve sheath tumors.
  • To describe incidence rate patterns and trends of primary nerve sheath tumors of the brain/CNS and the subset of vestibular schwannomas in two population-based incidence registries, data were obtained from 11 Central Brain Tumor Registry of the United States (CBTRUS) collaborating state registries and the Los Angeles County Cancer Surveillance Program (LACCSP) (1975-1998).
  • Multiplicative Poisson regression models were used to compare trends in primary nerve sheath tumors of the brain/CNS overall and in subgroups, including vestibular schwannomas, controlling for age, gender, race, microscopic confirmation, and region.
  • The overall incidence of primary nerve sheath tumors of the brain/CNS was 1.1 per 100,000 person-years (CBTRUS, 1995-1999 and LACCSP, 1995-1998).
  • The incidence of vestibular schwannomas was similar for both data sets: 0.6 per 100,000 person-years (CBTRUS, 1995-1999) and 0.8 per 100,000 person-years (LACCSP, 1995-1998).
  • Moreover, the incidence of primary nerve sheath tumors of the brain/CNS overall (CBTRUS, 1985-1999 and LACCSP, 1975-1998) and of vestibular schwannomas (CBTRUS, 1992-1999 and LACCSP, 1992-1998) increased over time.
  • However, the incidence of benign schwannomas in sites other than the acoustic nerve either decreased (CBTRUS, 1992-1999) or experienced no significant change (LACCSP, 1992-1998).
  • [MeSH-major] Neuroma, Acoustic / epidemiology. Registries

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  • (PMID = 16443943.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1871924
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92. Lee TX, Packer MD, Huang J, Akhmametyeva EM, Kulp SK, Chen CS, Giovannini M, Jacob A, Welling DB, Chang LS: Growth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells. Eur J Cancer; 2009 Jun;45(9):1709-20
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  • [Title] Growth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells.
  • BACKGROUND: Vestibular schwannomas (VS) frequently express high levels of activated AKT.
  • Small-molecule inhibitors of AKT signalling may have therapeutic potential in suppressing the growth of benign VS and malignant schwannomas.
  • METHOD: Primary VS and Schwann cells, human malignant schwannoma HMS-97 cells and mouse Nf2(-/-) Schwann cells and schwannoma cells were prepared to investigate the growth inhibitory and anti-tumour activities of OSU-03012, a celecoxib-derived small-molecule inhibitor of phosphoinositide-dependent kinase-1.
  • Cell proliferation assays, apoptosis, Western blot, in vivo xenograft analysis using SCID mice and immunohistochemistry were performed.
  • RESULTS: OSU-03012 inhibited cell proliferation more effectively in both VS and HMS-97 cells than in normal human Schwann cells.
  • The IC5) of OSU-03012 at 48h was approximately 3.1 microM for VS cells and 2.6 microM for HMS-97 cells, compared with the IC(50) of greater than 12 microM for human Schwann cells.
  • Similarly, mouse Nf2(-/-) schwannoma and Nf2(-/-) Schwann cells were more sensitive to growth inhibition by OSU-03012 than wild-type mouse Schwann cells and mouse schwannoma cells established from transgenic mice carrying the NF2 promoter-driven SV40 T-antigen gene.
  • Like VS cells, malignant schwannoma HMS-97 cells expressed high levels of activated AKT.
  • In vivo xenograft analysis showed that OSU-03012 was well tolerated and inhibited the growth of HMS-97 schwannoma xenografts by 55% after 9 weeks of oral treatment.
  • CONCLUSION: OSU-03012 is a potential chemotherapeutic agent for VS and malignant schwannomas.

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  • (PMID = 19359162.001).
  • [ISSN] 1879-0852
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] ENG
  • [Grant] United States / NIDCD NIH HHS / DC / DC005985-04; United States / NIDCD NIH HHS / DC / R01 DC005985; United States / NIDCD NIH HHS / DC / R01 DC005985-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / OSU 03012; 0 / Protein Kinase Inhibitors; 0 / Pyrazoles; 0 / Sulfonamides; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.2 / pyruvate dehydrogenase (acetyl-transferring) kinase
  • [Other-IDs] NLM/ NIHMS103963; NLM/ PMC2692816
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93. Wandong S, Meng L, Xingang L, Yuguang L, Shugan Z, Lei W, Chengyuan W: Cystic acoustic neuroma. J Clin Neurosci; 2005 Apr;12(3):253-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cystic acoustic neuroma.
  • To define the clinical characteristics of cystic acoustic neuroma, we retrospectively analyzed 22 patients with cystic acoustic neuroma and reviewed the literature with regard to clinical manifestation, imaging features, diagnosis, surgical procedures and prognosis.
  • An acoustic neuroma was defined as cystic according to the following criteria: the presence of hypodense/hypointense areas on CT or MRI, the identification of cystic elements at operation and histological verification.
  • At the end of surgery, the facial nerve was anatomically intact in 86.4% of cystic acoustic neuromas.
  • Complete removal of the tumor was achieved in 18 cases (81.8%).
  • We conclude that patients with cystic acoustic neuroma need prompt surgery with special attention paid to the preservation of the facial nerve.
  • [MeSH-major] Neuroma, Acoustic / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Facial Nerve / surgery. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neurosurgical Procedures. Prognosis. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 15851076.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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94. Di Giovanni A, Parente P, Colli R: Recurrent plexiform schwannoma in vestibular mucosa. G Chir; 2006 Mar;27(3):105-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent plexiform schwannoma in vestibular mucosa.
  • Schwannoma, also called neurilemmoma, is a benign neoplasm of peripheral nerve sheath.
  • An infrequent location of a multiple intraoral plexiform schwannoma arising on the branches of the facial nerve in the vestibular mucosa of a young male patient is here discussed.
  • [MeSH-major] Mouth Mucosa / pathology. Mouth Neoplasms. Neoplasm Recurrence, Local. Neurilemmoma

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  • (PMID = 16681871.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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95. Isaradisaikul S, Navacharoen N, Hanprasertpong C, Kangsanarak J, Panyathong R: Causes and time-course of vertigo in an ear, nose, and throat clinic. Eur Arch Otorhinolaryngol; 2010 Dec;267(12):1837-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Common causes of vertigo were benign paroxysmal positional vertigo (BPPV) 52.5%, Meniere's disease 14.6%, and sudden idiopathic hearing loss 2.9%.
  • Less common diagnoses were benign paroxysmal vertigo of childhood 0.7%, labyrinthitis 0.7%, and vestibular schwannoma 0.3%.
  • Rare conditions were delayed endolymphatic hydrops, Ramsey Hunt syndrome, otosyphilis, vestibular neuritis, temporal bone fracture, post-concussion syndrome, cerebellar infarction, epilepsy, cervical vertigo, Streptococcus suis meningitis, and psychogenic vertigo.
  • In the ear, nose, and throat clinic at Chiang Mai University, a tertiary university hospital, peripheral vestibular disorders were the main etiology of vertigo.
  • The three most common causes were BPPV, Meniere's disease, and sudden idiopathic hearing loss.

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  • (PMID = 20567978.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
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  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
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96. Lunsford LD, Niranjan A, Flickinger JC, Maitz A, Kondziolka D: Radiosurgery of vestibular schwannomas: summary of experience in 829 cases. J Neurosurg; 2005 Jan;102(s_supplement):195-199
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiosurgery of vestibular schwannomas: summary of experience in 829 cases.
  • OBJECT: Management options for vestibular schwannomas (VSs) have greatly expanded since the introduction of stereotactic radiosurgery.
  • Optimal outcomes reflect long-term tumor control, preservation of cranial nerve function, and retention of quality of life.
  • The average tumor volume was 2.5 cm<sup>3</sup>.
  • The median margin dose to the tumor was 13 Gy (range 10-20 Gy).
  • Unchanged hearing preservation was possible in 50 to 77% of patients (up to 90% in those with intracanalicular tumors).
  • Trigeminal symptoms were detected in less than 3% of patients whose tumors reached the level of the trigeminal nerve.
  • Tumor control rates at 10 years were 97% (no additional treatment needed).
  • Gamma knife surgery provides a low risk, minimally invasive treatment option for patients with newly diagnosed or residual vs. Cranial nerve preservation and quality of life maintenance are possible in long-term follow up.

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  • (PMID = 28306432.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; gamma knife surgery / radiosurgery / vestibular schwannoma
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97. Lee DJ, Maseyesva B, Westra W, Long D, Niparko JK, Califano J: Microsatellite analysis of recurrent vestibular schwannoma (acoustic neuroma) following stereotactic radiosurgery. Otol Neurotol; 2006 Feb;27(2):213-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microsatellite analysis of recurrent vestibular schwannoma (acoustic neuroma) following stereotactic radiosurgery.
  • HYPOTHESIS: Genetic and immunohistochemical studies may provide insight into the mechanisms of vestibular schwannoma (VS) recurrence following radiation therapy.
  • BACKGROUND: Stereotactic radiation therapy is an increasingly common alternative to microsurgical resection for the primary management of sporadic vs. The molecular mechanisms associated with recurrent vestibular schwannoma (VS) following radiation therapy are not known.
  • METHODS: Primary or irradiated VS tumors were fresh-frozen at the time of surgical resection and microdissected to undergo DNA extraction.
  • Paired normal and tumor DNA specimens were analyzed for allelic loss by PCR amplification of polymorphic dinucleotide repeat sequences.
  • Deletions on chromosome 10 are seen in both benign and higher-grade meningiomas and intracranial malignancies associated with radiotherapy.
  • [MeSH-major] Chromosomes, Human, Pair 22. Microsatellite Repeats. Neoplasm Recurrence, Local / genetics. Neuroma, Acoustic / genetics. Neuroma, Acoustic / surgery. Radiosurgery
  • [MeSH-minor] Base Sequence. Chi-Square Distribution. Chromosomes, Human, Pair 10. DNA Mutational Analysis. DNA, Neoplasm / blood. DNA, Neoplasm / chemistry. DNA, Neoplasm / genetics. DNA, Neoplasm / isolation & purification. Gene Expression Regulation, Neoplastic. Genes, bcl-2 / genetics. Genes, p53 / genetics. Humans. Immunohistochemistry. Loss of Heterozygosity. Neurofibromin 2 / analysis. Neurofibromin 2 / genetics

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  • (PMID = 16436992.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Neurofibromin 2
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98. Coca A, Gómez JR, Llorente JL, Rodrigo JP, Núñez F, Sevilla MA, Suárez C: [Complications and sequelae in acoustic neuroma surgery]. Acta Otorrinolaringol Esp; 2007 Dec;58(10):470-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Complications and sequelae in acoustic neuroma surgery].
  • [Transliterated title] Complicaciones y secuelas en la cirugía de los neurinomas del acústico.
  • OBJECTIVE: To evaluate the complications and sequelae of acoustic neuroma surgery, according to tumour size.
  • PATIENTS AND METHOD: A retrospective analysis of 120 patients who underwent microsurgical resection of vestibular schwannomas between November 1994 and September 2006 was undertaken.
  • The facial nerve was anatomically and functionally preserved in 103 cases on long-term follow-up (85.4 %).
  • The cochlear nerve was functionally preserved (Gardner-Robertson class 1 and 2) in 54.4 % of the small tumours with useful preoperative hearing.
  • CONCLUSIONS: Despite the progress in the surgical treatment of acoustic neuromas, a considerable rate of complications and sequelae still remains.
  • [MeSH-major] Neuroma, Acoustic / epidemiology. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / statistics & numerical data. Postoperative Complications / epidemiology


99. Maruyama T, Muragaki Y, Hori T: [Surgical technique for vestibular schwannoma]. No Shinkei Geka; 2006 Jul;34(7):681-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Surgical technique for vestibular schwannoma].
  • [MeSH-major] Neuroendoscopy / methods. Neuroma, Acoustic / surgery. Neurosurgical Procedures / methods. Radiosurgery

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  • (PMID = 16841704.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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100. Kano H, Kondziolka D, Niranjan A, Flannery TJ, Flickinger JC, Lunsford LD: Repeat stereotactic radiosurgery for acoustic neuromas. Int J Radiat Oncol Biol Phys; 2010 Feb 1;76(2):520-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Repeat stereotactic radiosurgery for acoustic neuromas.
  • PURPOSE: To evaluate the outcome of repeat stereotactic radiosurgery (SRS) for acoustic neuromas, we assessed tumor control, clinical outcomes, and the risk of adverse radiation effects in patients whose tumors progressed after initial management.
  • METHODS AND MATERIALS: During a 21-year experience at our center, 1,352 patients underwent SRS as management for their acoustic neuromas.
  • We retrospectively identified 6 patients who underwent SRS twice for the same tumor.
  • All patients had imaging evidence of tumor progression despite initial SRS.
  • RESULTS: At a median follow-up of 29 months after the second SRS (range, 13-71 months), tumor control or regression was achieved in all 6 patients.
  • CONCLUSIONS: With this limited experience, we found that repeat SRS for a persistently enlarging acoustic neuroma can be performed safely and effectively.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery
  • [MeSH-minor] Adult. Aged. Disease Progression. Humans. Magnetic Resonance Imaging. Middle Aged. Radiotherapy Dosage. Reoperation / utilization. Retrospective Studies






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